laboratory animals: Topics by WorldWideScience.org

Utility of Recycled Bedding for Laboratory Rodents

A retrospective study of the relationship of season to the absorption of radiolead in laboratory rats was performed using data representing 305 animals from 36 experiments over 6 calendar years. Male...Full Text Available

1987-08-01

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The Relationship of Urinary Metabolites of Carbaryl/Naphthalene and Chlorpyrifos with Human Semen Quality

Animal facilities generate a large amount of used bedding containing excrement as medical waste. We developed a recycling system for used bedding that involves soft hydrothermal processing. In this...Full Text Available

2009-07-01

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TLD assessment of mouse dosimetry during microCT imaging

Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between...Full Text Available

2004-12-01

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Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals

Advances in laboratory animal imaging have provided new resources for noninvasive biomedical research. Among these technologies is microcomputed tomography (microCT) which is widely used to obtain high...Full Text Available

2008-09-01

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Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

Background:The present study was undertaken to evaluate the anti-ulcer and antioxidant activities of the ethanol extract of Lagenaria breviflora (EELB)...Full Text Available

2011-01-01

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On the Industries of Animals.

A remarkable discovery of recent years is that, despite the complexity of ageing, simple genetic interventions can increase lifespan and improve health during ageing in laboratory animals. The pathways...Full Text Available

2011-05-01

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Transactions and Proceedings of the Royal Society of New Zealand 1868-1961

Full Text Available

1897-01-01

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Metabolism of benzo(a)pyrene by isolated perfused testis and testicular homogenate

Severity of Locomotor and Cardiovascular Derangements after Experimental High-Thoracic Spinal Cord Injury is Anesthesia Dependent in Rats.

In an effort to improve the extrapolation of laboratory data to man and estimate risk of human reproductive toxicity associated with environmental exposure, the pharmacokinetic parameters of the testicular compartment are being studied. Of particular interest is the variety of enzyme systems capable of activating and detoxicating environmental chemicals and drugs. This report compares the metabolism of benzo(a)pyrene by the isolated perfused testis and testicular homogenates in vitro. The cell free in vitro system metabolized benzo(a)pyrene at a much greater rate than the perfused testis and produced a different spectrum of metabolites. Reliable laboratory prediction of biotransformation by the whole organ or intact animal is an essential aspect of reproductive toxicology.

1980-12-01

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Risk estimates of liver cancer due to aflatoxin exposure from peanuts and peanut products

Abstract Anesthetics affect outcomes from central nervous system (CNS) injuries differently. This is the first study to show how two commonly used anesthetics affect continuously recorded hemodynamic parameters and locomotor recovery during a 2-week period after two levels of contusion spinal cord injury (SCI) in rats. We hypothesized that the level of cardiovascular depression and recovery of locomotor function would be dependent upon the anesthetic used during SCI. Thirty-two adult female rats were subjected to a sham, 25-mm or 50-mm SCI at T3-4 under pentobarbital or isoflurane anesthesia. Mean arterial pressure (MAP) and heart rate (HR) were telemetrically recorded before, during, and after SCI. Locomotor function recovered best in the 25-mm-injured isoflurane-anesthetized animals. There was no significant difference in locomotor recovery between the 25-mm-injured pentobarbital-anesthetized animals and the 50-mm-injured ...

2011-08-01

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On Immortality in the Animal World.

An assessment was undertaken of the risk of liver cancer in the USA associated with aflatoxin ingestion from peanuts. Both laboratory-animal data and epidemiological data collected from the scientific literature and several prominent mathematical extrapolation techniques were used. Risk estimates differed by a factor of greater than 1000 when the extrapolated results of three selected animal studies were analysed. Dose-response data for the male Fischer rat, the most sensitive mammalian species studied, produced an estimate of 158 cases of liver cancer per year in the USA at current levels of aflatoxin exposure. An estimate of 58 annual cases was predicted on the basis of epidemiological data of populations in Africa and Thailand.

1984-06-01

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Transactions and Proceedings of the Royal Society of New Zealand 1868-1961

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1890-01-01

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State of work for services provided by the Waste Sampling and Characterization Facility for effluent monitoring

PET/MRI hybrid imaging: devices and initial results

This document defines the services the Waste Sampling and Characterization Facility (WSCF) shall provide Effluent Monitoring (EM) throughout the calendar year for analysis. The internal memo contained in Appendix A identifies the samples Em plans to submit for analysis in CY-1995. Analysis of effluent (liquid and air discharges) and environmental (air, liquid, animal, and vegetative) samples is required using standard laboratory procedures, in accordance with regulatory and control requirements. This report describes regulatory reporting requirements and WSCF services and data quality objectives.

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Elk and Deer Study, Material Disposal Area G, Technical Area 54: Source document

The combination of functional and morphological imaging technologies such as positron emission tomography (PET) and X-ray computed tomography (CT) has shown its value in the clinical and preclinical field. However, CT provides only very limited soft-tissue contrast and exposes the examined patient or laboratory animal to a high X-ray radiation dose. In comparison to CT, magnetic resonance tomography (MRI) provides excellent soft-tissue contrast and allows for nuclear magnetic resonance spectroscopy (NMRS) or functional MRI (fMRI). Thus, the combination of PET and MRI has been pursued for several years. First approaches have succeeded using conventional photo multiplier tube (PMT) technology together with light fibers to transfer scintillation light away from the high magnetic field. Latest PET/MRI developments use solid-state light detectors that can be operated even at high magnetic fields. Initial pilot studies with prototype ...

2008-06-01

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Capacity issues in transport of animals for slaughtering in Gilde

As nuclear research has become more prevalent, environmental contamination from the disposal of radioactive waste has become a prominent issue. At Los Alamos National Laboratory (LANL) in northern New Mexico, radioactive contamination from disposal operations has raised some very specific concerns. Material Disposal Area G (Area G) is the primary low-level radioactive waste disposal site at LANL and occupies an area adjacent to land belonging to the Native American community of the Pueblo of San Ildefonso. Analyses of soil and vegetation collected from the perimeter of Area G have shown concentrations of radionuclides greater than background concentrations established for northern New Mexico. As a result, Pueblo residents had become concerned that contaminants from Area G could enter tribal lands through various ecological pathways. The residents specifically questioned the safety of consuming meat from elk and deer that forage near Area G and then migrate onto ...

1999-09-01

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Norwegian Open Research Archives (NORA)

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Heavy Metals Effect on Animal Cells

International Science & Technology Center (ISTC)

Studies of the Superheavy-metal Effect as a Stress-factor on Protein Biosynthesis and Cytoskeleton Integrity in Animal Cells

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Use of a point-of-care beta-hydroxybutyrate sensor for detection of ketonemia in dogs.

Serological testing-An alternative to boosters?

The urine test strip is the most common test used to detect ketones in veterinary patients, but it can underestimate the degree of ketonuria and hence, ketonemia. Additionally, adequate urine samples for analysis may be difficult to obtain from dehydrated animals. The standard method used to detect and monitor ketonemia in human medicine is measurement of serum or whole blood beta-hydroxybutyrate (?HOB). A point-of-care (POC) analyzer has been validated for this purpose in humans. This study compared the accuracy of the POC device to an enzymatic reaction laboratory method for measurement of ?HOB in dogs. Although the POC sensor tended to overestimate ?HOB concentrations, there was good correlation (R(2) = 0.96) and good agreement between the 2 methods with a bias +/- precision of 0.0860 +/- 0.3410 mmol/L ?HOB. The POC ?HOB sensor can be useful for assessing ketonemia in dogs. PMID:21119867

2010-09-01

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British Library Electronic Table of Contents (United Kingdom)

The issue of the duration of immunity, particularly for the modified live viral components of veterinary vaccines, has been a significant part of the recent vaccination debate. One manufacturer has increased the recommended booster interval for these components to 3 years give name and another now states `up to 4 years' immunity.There remain many unanswered questions regarding this duration of immunity (DOI). Studies suitable for data sheet claims are time consuming and costly and can only be performed in laboratory dogs under tightly controlled conditions. Evidence from rabies serology testing in the UK shows that the response of individual animals to routine vaccination is highly variable. Much of the published field evidence on the persistence of antibody titres originates from North Am...

2006-01-01

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Penile Rehabilitation after Radical Prostatectomy: Where Do We Stand and Where Are We Going?

British Library Electronic Table of Contents (United Kingdom)

ABSTRACT Introduction. Postprostatectomy erectile dysfunction (ED) remains a serious quality-of-life issue. Recent advances in the understanding of the mechanism of postprostatectomy ED have stimulated great attention toward penile rehabilitation. Aim. This review presents and analyzes a contemporary series of the recent medical literature pertaining to penile rehabilitation therapy after radical prostatectomy (RP). Main Outcome Measures. The laboratory and clinical studies related to penile rehabilitation are analyzed. The validity of the methodology and the conclusion of the findings from each study are determined. Methods. The published and presented reports dealing with penile rehabilitation following RP in human and cavernous nerve injury in animal models are reviewed. Results. Exciti...

2007-01-01

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PET/MRI hybrid imaging: devices and initial results

British Library Electronic Table of Contents (United Kingdom)

The combination of functional and morphological imaging technologies such as positron emission tomography (PET) and X-ray computed tomography (CT) has shown its value in the clinical and preclinical field. However, CT provides only very limited soft-tissue contrast and exposes the examined patient or laboratory animal to a high X-ray radiation dose. In comparison to CT, magnetic resonance tomography (MRI) provides excellent soft-tissue contrast and allows for nuclear magnetic resonance spectroscopy (NMRS) or functional MRI (fMRI). Thus, the combination of PET and MRI has been pursued for several years. First approaches have succeeded using conventional photo multiplier tube (PMT) technology together with light fibers to transfer scintillation light away from the high magnetic field. Latest...

2008-01-01

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Continuing the search for a fundamental law of mortality

Continuing the search for a fundamental law of mortality

For 170 years, scientists have attempted to explain why consistent temporal patterns of death are observed among individuals within populations. Historical efforts to identify a {open_quotes}law of mortality{close_quotes} from these patterns ended in 1935 when it was declared that such a law did not exist. These empirical tests for a law of mortality were constructed using mortality curves based on all causes of death. We predicted that patterns of mortality consistent with the historical concept of a law would be revealed if mortality curves for species were constructed using only senescent causes of death. Using data on senescent mortality for laboratory animals and humans, we demonstrate that patterns of mortality overlap when compared on a biologically comparable time scale. These results are consistent with the existence of a law of mortality following sexual maturity as asserted by Benjamin Gompertz and Raymond Pearl. The societal, ...

1997-08-01

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What Do We Feed to Food-Production Animals? A Review of Animal Feed Ingredients and Their Potential Impacts on Human Health

for 170 years, scientists have attempted to explain why consistent temporal patterns of death are observed among individuals within populations. Historical efforts to identify a `law of mortality` from these patterns ended in 1935 when it was declared that such a law did not exist. These empirical tests for a law of mortality were constructed using mortality curves based on all causes of death. We predicted patterns of mortality consistent with the historical concept of a law would be revealed if mortality curves for species were constructed using only senescent causes of death. Using data on senescent mortality for laboratory animals and humans, we demonstrate patterns of mortality overlap when compared on a biologically comparable time scale. The results are consistent with the existence of a law of mortality following sexual maturity. The societal, medical, and research implications of such a law are discussed.

1996-03-01

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WILD PIGS: BIOLOGY, DAMAGE, CONTROL TECHINQUES AND MANAGEMENT

ObjectiveAnimal feeding practices in the United States have changed considerably over the past century. As large-scale, concentrated production methods have become the predominant...Full Text Available

2007-05-01

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Prospective cognition in animals.

The existence of problems with wild pigs (Sus scrofa) is nothing new to the Western Hemisphere. Damage by these introduced animals was reported as far back as 1505 by the early Spanish colonies in the Caribbean, where wild pigs were killing the colonists cattle. Droves of these animals also ravaged cultivated crops of maize and sugarcane on islands in the West Indies during this same time period. These wild pigs reportedly were very aggressive and often attacked Spanish soldiers hunting rebellious Indians or escaped slaves on these islands, especially when these animals were cornered. The documentation of such impacts by introduced populations of this species in the United States has subsequently increased in recent years, and continued up through the present (Towne and Wentworth. 1950, Wood and Barrett 1979, Mayer and Brisbin 1991, Dickson et al. 2001). In spite of a fairly constant history in this country since the early ...

2009-12-31

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Pitch discrimination by ferrets for simple and complex sounds

The debate about whether or not animals have foresight has focused on whether animals can be shown to have episodic future thinking, that is the ability to travel mentally in time and see themselves in the future. This focus has distracted from consideration of other forms of foresight that animals demonstrate. We propose a framework for examining future-oriented behaviours and then discuss the evidence for future thinking in animals. In the final section we examine some perspectives of future thinking and suggest that there are future-oriented capabilities of animals that do not involve mental time travel but may yet involve future thinking which deserve further investigation. PMID:20522320

2009-03-01

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A Dose- and Time-Controllable Syngeneic Animal Model of Breast Cancer Microcalcification

Although many studies have examined the performance of animals in detecting a frequency change in a sequence of tones, few have measured animals' discrimination of the fundamental frequency...Full Text Available

2009-09-01

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The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality.

IntroductionThe development of novel diagnostic agents for the detection of breast cancer microcalcifications requires a reliable animal model. Based on previous...Full Text Available

2010-07-01

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Technology development, evaluation, and application (TDEA) FY 1997 progress report

Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1-naphthol (1N), a metabolite of carbaryl and naphthalene, and 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, are associated with decreased semen quality in humans. Subjects (n=272) were recruited through a Massachusetts infertility clinic. Individual exposures were measured as spot urinary concentrations of 1N and TCPY adjusted using specific gravity. Semen quality was assessed as sperm concentration, percent motile sperm, and percent sperm with normal morphology, along with sperm motion parameters (straight-line velocity, curvilinear velocity, and linearity). Median TCPY and 1N ...

2004-12-01

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Inventory of tritium concentration of waters in the Manche department; Inventaire des concentrations en tritium des eaux du Departement de La Manche

The public expects that the Los Alamos National Laboratory (LANL) will operate in a manner that prevents negative impacts to the environment and protects the safety and health of its employees and the public. To achieve this goal within budget, the Department of Energy (DOE) and LANL must develop new and improved environment, safety, and health (ES and H) technologies and implement innovative, more cost-effective ES and H approaches to operations. In FY95, the Environment, Safety, and Health (ESH) Division initiated a Technology Development, Evaluation, and Application (TDEA) program. The purpose of this unique program is to test and develop technologies that solve LANL ES and H problems and improve the safety of LANL operations. This progress report presents the results of 10 projects funded in FY97 by the TDEA Committee of the Environment, Safety, and Health Division. Products generated from the projects funded in FY97 included implementation of radiation worker ...

1998-05-01

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In vivo effects of cadmium chloride on certain aspects of carbohydrate metabolism in the tissues of a freshwater field crab Barytelphusa guerini

For the inventory of water tritium concentration in the Manche department, it is the complementarity that animated the work opened during year 2001. To answer to a commune sensitivity such water quality, particularly drinking water at tap, the A.C.R.O. laboratory brought its know how to make and its technical means in the area of tritium analysis and the general council brought its know how to make and its logistics means in matter of sanitary control. This collaboration has allowed to supply an indication on the tritium content of the distribution waters of thirty of the most important cities of the department. Then, it allowed to inform on the radiological situation (in relation with the tritium presence) of coast waters and principal rivers waters. More than 160 controls have been realised between the months of march 2001 and february 2002. Only the tritium under the shape of tritiated water has been measured. The measures have been made by ...

2007-07-01

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Excess of seminomas observed in Vietnam service U.S. military workingn> dogs.

Cadmium is a toxic, non-essential heavy metal inhibiting numerous enzymes with functional sulfhydryl groups. Among the animals, aquatic organisms are most sensitive to heavy metals. Various aspects of toxic effects of cadmium pollution on fishes have been extensively reviewed. Survey of literature reveals that relatively few attempts have been made on the various aspects of cadmium toxicity in crustaceans and these studies were mainly devoted to marine forms. The freshwater crustaceans, particularly the freshwater field crab, Barytelphusa guerini, received less attention. This crab forms one of the major components of the paddy field ecosystem and has an edible importance among local populations. Apart from this, these crabs are easily available, maintainable in the laboratory and data obtained in this study can be extrapolated to other crustaceans. The present study reports the influence of cadmium on certain aspects of carbohydrate metabolism ...

1989-06-01

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A review of the studies on the wholesomeness of irradiated wheat, conducted at the National Institute of Nutrition, India

During the Vietnam War, US military working dogs served with their companion dog handlers in close proximity, sharing common exposures to war-related activity, many zoonotic infectious agents, chemical pesticides, phenoxy herbicides, and extensive use of therapeutic drugs. To gain insight into the effects of the Vietnam experience, we investigated the occurrence of neoplasms in military working dogs based on standard necropsy examination by the Armed Forces Institute of Pathology. We observed that these dogs experienced significant elevated risks for testicular seminoma and, independently, testicular dysfunction. Experimental evidence shows testicular dysfunction and impaired spermatogenesis in laboratory animals exposed to phenoxy herbicides, dioxin, or tetracycline, and antibiotic used extensively in military working dogs in Vietnam. Because an unexplained significant decrease in sperm quality in Vietnam veterans has been observed by the ...

1990-06-20

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A new visitor centre for CMS

The wholesomeness of irradiated wheat was investigated in a series of experiments involving several species of animals and a small number of children, at the National Institute of Nutrition in India. Our observations indicated some effects following the feeding of freshly irradiated wheat while no such changes were found in the groups fed either unirradiated or stored irradiated wheat. Also, there were no significant differences between the groups fed unirradiated and stored irradiated wheat. Based on these results, a recommendation had been made to the government that when subjected to irradiation, wheat should be stored for at least 3 months before considering it as safe for human consumption. Similar experiments conducted in an establishment of the Department of Atomic Energy in India indicated no undesirable effects, unlike those found in our studies, and this had led to the development of a serious controversy. In this paper, we have not only reviewed our ...

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CERN Multimedia

At the inauguration of the new CMS visitor centre. The CMS experiment inaugurated a new visitor centre at its Cessy site on 14 June. This will allow the thousands of people who come to CERN each year to follow the construction of one the Laboratory's flagship experiments first-hand. CERN receives over 20,000 visitors each year. Until recently, many of them were taken on a guided tour of one of the LEP experiments. With the closure of LEP, however, trips underground are no longer possible, and the Visits' Service has put in place a number of other itineraries (Bulletin 46/2000). Since the CMS detector will be almost entirely constructed in a surface hall, it is now taking a big share of the limelight. The CMS visitor centre has been built on a platform overlooking CMS construction. It contains a set of clear descriptive posters describing the experiment, along with a video projection showing animations and movies about CMS construction. In the ...

2001-01-01

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Visible Earth: Typhoon Aere

Study on the Development of Solid Fuel of Animal Wastes for Heating of Agricultural Facilities

NASA's Visible Earth catalog of NASA images and animations of our home planet.

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KoreaScience (Korea)

Full Text Available

2007-10-01

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NAME=\\

...Assemblages of plants and invertebrate animals of tumulus (organic mound) springs of the Swan Coastal Plain Assemblages of plants and invertebrate animals of tumulus ...organic mound) springs of the Swan Coastal Plain [Skip navigation links] About us | Contact us | Publications |...ecological communities Assemblages of plants and invertebrate animals of tumulus (organic mound) springs of the Swan Coastal Plain Advice to the Minister for the ...of the 'Assemblages of plants and invertebrate animals of tumulus (organic mound) springs of the Swan Coastal Plain' community sufficient to distinguish it from ...

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Creative Australia

Animal Brucellosis in the Kyrgyz Republic

animation The structure of the creative industries is changing Previously there were small numbers of producers and a

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International Science & Technology Center (ISTC)

Epizootological Monitoring of Brucellosis and Methods of its Eradication in the Kyrgyz Republic

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University of Central Lancashire - Facilities

[The possibilities for the laboratory diagnosis of schizophrenia].

...specialised laboratories for pharmaceutics, tissue culture and molecular biology Excellent Laboratory Facilities Tissue Culture Facilities Molecular Biology Laboratory ...

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Emerging laboratory biosecurity issues.

PMID:2042311

1991-02-01

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??????? ?????????(Applied Aerodynamics Laboratory)

No abstract prepared.

2005-04-01

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KoreaScience (Korea)

Full Text Available

2011-03-01

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Clinical and ultrasonographic findings, diagnosis and treatment of pyelonephritis in 17 cows

British Library Electronic Table of Contents (United Kingdom)

The goal of the present study was to describe the clinical, haematological and ultrasonographic findings and treatment of 17 cattle with pyelonephritis. Fifteen cattle had an abnormal general condition, which varied in severity; five animals had signs of colic. The urine was brownish-red in 11 animals and cloudy in 13. Clumps of purulent material were seen in the urine of nine animals and clots of blood in two. The specific gravity was lower than normal in 13 animals and ranged from 1.005 to 1.020. A urine test strip revealed protein in 16 animals, blood in 16 and leukocytes in 12. Bacteriological examination of urine yielded Corynebacterium renale in 11 animals, Arcanobacter pyogenes in two and Escherichia coli in one. Rectal examination revealed abnormalities of the urinary tract in 11 a...

2008-01-01

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Why study the use of animal products in traditional medicines?

Universal model for water costs of gas exchange by animals and plants

The World Health Organization (WHO) estimates that as many as 80% of the world's more than six billion people rely primarily on animal and plant-based medicines. The healing of human ailments by using...Full Text Available

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Transmission of Salmonella mbandaka to cattle from contaminated feed.

For terrestrial animals and plants, a fundamental cost of living is water vapor lost to the atmosphere during exchange of metabolic gases. Here, by bringing together previously developed models for...Full Text Available

2010-05-04

48

Specific genetic modifications of domestic animals by gene targeting and animal cloning

Salmonella mbandaka was isolated from cattle on three dairy farms. The duration of infection was less than four weeks and none of the animals became clinically ill. The animals had all consumed a diet...Full Text Available

1982-04-01

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Mycotoxins in fungal contaminated samples of animal feed from western Canada, 1982-1994.

The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large...Full Text Available

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Molecular determinants archetypical to the phylum Nematoda

Feed samples from 94 cases involving fungal contamination and suspected mycotoxicosis of farm animals in western Canada were examined during 1982-1994 to assess the incidence of mycotoxins. Samples...Full Text Available

1997-01-01

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Isolation of an Escherichia coli K4 kfoC mutant over-producing capsular chondroitin

BackgroundNematoda diverged from other animals between 600–1,200 million years ago and has become one of the most diverse animal phyla on earth. Most nematodes are free-living...Full Text Available

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From spectral information to animal colour vision: experiments and concepts

BackgroundChondroitin sulphate is a complex polysaccharide having important structural and protective functions in animal tissues. Extracted from animals, this compound is used as...Full Text Available

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Distribution, Frequency, and Diversity of Bacillus thuringiensis in an Animal Feed Mill

Many animals use the spectral distribution of light to guide behaviour, but whether they have colour vision has been debated for over a century. Our strong subjective experience of colour and the fact...Full Text Available

2010-06-07

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Development Document for Proposed Effluent Limitations Guidelines and Standards for the Concentrated Aquatic Animal Production Industry Point Source Category.

Bacillus thuringiensis was isolated from 36 of 50 residue samples obtained from an animal feed mill (a stored-product environment). Of 710 selected colonies having Bacillus...Full Text Available

1992-04-01

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Components of change in the evolution of learning and unlearned preference

This section presents background information supporting the development of effluent limitations guidelines and standards for the concentrated aquatic animal production (CAAP) point source category. Section 1.1 presents the legal authority to regulate the ...

2002-01-01

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Comparative aspects of pesticide metabolism in plants and animals.

Several phenomena in animal learning seem to call for evolutionary explanations, such as patterns of what animals learn and do not learn. While several models consider how evolution should influence...Full Text Available

2009-09-07

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Comparative and alternative approaches and novel animal models for aging research

Pesticide chemicals are an important component of modern agriculture. Through their use, plants and animals are exposed to pesticides directly and indirectly from transport through soil, water, and...Full Text Available

1978-12-01

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Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models

This special issue of AGE showcases powerful alternative or unconventional approaches to basic aging research, including the use of exceptionally long-lived animal model species and...Full Text Available

2008-09-01

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Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?

Antinociceptive and anti-inflammatory activities of the ethanol extract from Annona muricata L. leaves were investigated in animal models. The extract delivered per oral route (p.o.)...Full Text Available

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Amazon Deforestation Model

The amyloidoses are the prototype gain of toxic function protein misfolding diseases. As such, several naturally occurring animal models and their inducible variants provided some of the first...Full Text Available

2009-08-20

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A Serological Survey of Sera from Domestic Animals on Easter Island

This series of animations depicts the results of a computer simulation of the effects of deforestation on the surface temperature and precipitation in the Amazon region. Six animations are shown - a control simulation, a deforestation simulation, and the difference between the two for both surface temperature and rainfall. The period simulated is the second half of 1987.

1994-03-13

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Visible Earth: Food Additives

Animals' sera collected on Easter Island from December 1964 to February 1965 were tested by appropriate methods for the presence of antibodies to various infections. These included, ornithosis, Q-fever,...Full Text Available

1968-04-01

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Development of QTL Mapping Populations

Feb 25, 2008 ... NASA's Visible Earth catalog of NASA images and animations of our home planet.

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Sunscreen

Medline Plus

... Animal & Veterinary Cosmetics Radiation-Emitting Products Tobacco Products Drugs Home > Drugs > Resources for You > Information for Consumers (Drugs) Section ...

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Clinical and ultrasonographic findings, diagnosis and treatment of pyelonephritis in 17 cows.

The objective of this animation is to develop a QTL mapping population for locating and characterizing the genes responsible for resistance to tan spot disease of wheat.

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Species comparison of acute inhalation toxicity of ozone and phosgene

The goal of the present study was to describe the clinical, haematological and ultrasonographic findings and treatment of 17 cattle with pyelonephritis. Fifteen cattle had an abnormal general condition, which varied in severity; five animals had signs of colic. The urine was brownish-red in 11 animals and cloudy in 13. Clumps of purulent material were seen in the urine of nine animals and clots of blood in two. The specific gravity was lower than normal in 13 animals and ranged from 1.005 to 1.020. A urine test strip revealed protein in 16 animals, blood in 16 and leukocytes in 12. Bacteriological examination of urine yielded Corynebacterium renale in 11 animals, Arcanobacter pyogenes in two and Escherichia coli in one. Rectal examination revealed abnormalities of the urinary tract in 11 animals; there was dilatation of the left ureter ...

2007-03-23

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Species comparison of acute inhalation toxicity of ozone and phosgene

A comparison of the concentration-response effects of inhaled ozone (O/sub 3/) in different species of laboratory animals was made in order to better understand the influence of the choice of species in inhalation studies of this gas. The effect of 4-hour exposure to ozone (O/sub 3/) at concentrations of 0.0, 0.2, 0.5, 1.0, and 2.0 ppm was determined in rabbits, guinea pigs, rats, hamsters and mice. Lavage fluid protein (LFP) accumulation 18 hr after exposure was used as the indicator of O/sub 3/-induced pulmonary edema. All species had similar basal levels of LFP (250-350 ug/ml) when a volume of saline which approximated the total lung capacity was used for lavage of the collapsed lungs. Exponential dose-response curves were seen in all species except guinea pigs, which showed significant increases in LFP at low O/sub 3/ concentrations (0.2 ppm) and a leveling off of response at the higher O/sub 3/ levels. Other species usually showed ...

1986-01-01

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Comparison of bone cancer risks in beagle dogs for inhaled plutonium-238 dioxide, inhaled strontium-90 chloride, and injected strontium-90

A comparison of the concentration-response effects of inhaled ozone (O/sub 3/) and phosgene (COCl/sub 2/) in different species of laboratory animals was made in order to better understand the influence of the choice of species in inhalation toxicity studies. The effect of 4-h exposures to ozone at concentrations of 0.2, 0.5, 1.0, and 2.0 ppm, and to COCl/sub 2/ and 0.1, 0.2, 0.5, and 1.0 ppm was determined in rabbits, guinea pigs, rats, hamsters, and mice. Lavage fluid protein (LFP) accumulation 18-20 h after exposure was used as the indicator of O3- and COCl/sub 2/-induced pulmonary edema. All species had similar basal levels of LFP (250-350 mg/ml) when a volume of saline that approximated the total lung capacity was used to lavage the collapsed lungs. Ozone effects were most marked in guinea pigs, which showed significant effects at 0.2 ppm and above. Mice, hamsters, and rats showed effects at 1.0 ppm O3 and above, while rabbits responded ...

1986-01-01

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There is a continuing need to understand dose-response relationships for ionizing radiation in order to protect the health of the public and nuclear workers from undue exposures. However, relatively few human populations have been exposed to doses of radiation high enough to cause observable, long-term health effects from which to derive dose-response relationships. This is particularly true for internally deposited radionuclides, although much effort has been devoted to epidemiological studies of the few types of exposures available, including lung cancers in uranium miners form the inhalation of the radioactive decay products of Ra, liver cancers in patients injected with Thorotrast X-ray contrast medium containing Th, bone cancers in radium dial painters who ingested Ra, and bone cancers in patients who received therapeutic doses of Ra. These four types of exposures to internally deposited radionuclides provide a basis for understanding the health effects of many other radionuclides ...

1995-12-01

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NRL Fact Book 2010

... Tactical Electronic Warfare Division (Code 5700) Visualization Laboratory Transportable step frequency radar Vehicle development laboratory ...

2011-05-15

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NRL Fact Book

Development of radioimmunometric assays and kits for non-clinical applications. Proceedings of a final research coordination meeting

... Tactical Electronic Warfare Division (Code 5700) Visualization Laboratory Transportable step frequency radar Vehicle development laboratory ...

2011-05-15

72

Thermal basis for disruption of operant behavior by microwaves in three animal species

Immunoassays are versatile analytical techniques that had a leading role in various clinical applications, during the last four decades. The studies carried out by Rosalyn Yalow, Solomon Berson and Roger Ekins in the 1960s gave a breakthrough in the development of this novel analytical method. Sensitivity up to femtomolar concentrations, high specificity and universal application to different classes of molecular species made immunoassay a very useful tool in analytical investigation. The expertise acquired by immunochemists in producing antibodies against any antigen and the ability of radiochemists in labeling the antigens with "1"2"5I without affecting the active site are the two main factors responsible for the above development. There are concerns about the safety and health of humans due to the high-level contamination of environment by pesticides, industrial compounds and metals, anabolic steroids in milk and meat products, and presence of mycotoxins in food and feed ...

2004-12-06

73

Organic farming in the Nordic countries--animal health and production.

A large variety of microwave producing devices are used in contemporary naval communications and weapons systems. Public and scientific concern about potential biological effects of microwave irradiation such as produced by these various devices requires documentations of such effects. Currently, the only well documented direct effect of microwaves is heating of the exposed organism. The present report is of a series of studies whose aim was to explore several microwave frequencies and their effect on performance and simultaneously to investigate the relationship to core heating in the exposed animals. Three difficult sized species of animals were used so that generalization to larger animals could be made. Rats, squirrel monkeys, and rhesus monkeys showed consistent effects of 60-minute exposures to microwaves when their body temperatures were increased at least 1 C above baseline temperatures. Performance was not reliably ...

1982-06-01

74

Influence of animal age upon antioxidant-modified UV carcinogenesis

Organic farming (or ecological agriculture) is of growing importance in the agricultural sector worldwide. In the Nordic countries, 1-10% of the arable land was in organic production in 1999. Organic farming can be seen as an approach to agriculture where the aim is to create integrated, humane, environmentally and economically sustainable agricultural production systems. Principles like nutrient recycling, prevention rather than treatment and the precautionary principle are included in aims and standards. Animal welfare is another hallmark of organic livestock production but despite this, several studies have indicated severe health problems e.g. in organic poultry production in Denmark. Also the quality of animal food products in relation to human health, particularly the risk of zoonotic infections, has been debated. For these reasons there is a need for improvement of production methods and animal health status. Vets ...

2001-01-01

75

Use of X-ray fluorescence analysis in the study of archeological samples

Studies were undertaken to examine the effects of animal age on the anticarcinogenic properties of antioxidants. Female hairless mice, 2.5, 4.5 and 9.5 months of age, were subjected to daily irradiation from Westinghouse BZS-WLG lamps for 19 weeks. Experimental groups of animals were maintained on a commercial rodent meal supplemented with a 2% (w/w) antioxidant mixture. Control groups received only the meal. Tumour latency, expressed as median time to tumor development, was significantly greater for all age groups receiving antioxidants than for their similarly aged controls. However, the response to antioxidants appeared to decrease with age and the antioxidant effect was significantly less in the 9.5 month-old group than in the 2.5 month-old group. Likewise, the two youngest groups receiving antioxidants demonstrated a significantly fewer number of tumors per animal. It is concluded that animal age ...

76

Removal of "2"3"9Pu from the rat with an orally administered chelon

Radionuclide X-ray fluorescence analysis (XFA) was used in the determination of the contents of metal residues in dosing plates for coin minting. XFA was also used for the determination of the strontium/calcium ratio in bone samples of different animals with the aim to obtain information on the food composition of these animals. It was found that bones of different animals can be distinguished based on the Sr/Ca ratio. No significant differences in the Sr/Ca ratio were observed in human bones of individuals from different social groups. (author). 1 fig., 5 tabs., 4 refs.

1988-09-26

77

Effect on the reproductive functions of female rhesus monkeys of feeding irradiated wheat flour and potato diet

The oral administration of 2,3-dihydroxybenzoic acid (DHB) to rats injected intravenously 1 hr previously with "2"3"9Pu citrate caused an increase in urinary excretion of Pu about 8 times that of animals treated with 0.9% NaCl (controls). Liver retention of Pu was decreased from 18% at 2 days in the control animals to 11% in DHB-treated rats. The skeletal retention was similarly reduced from 56% in the control group to 40% in the DHB-treated animals.

1977-05-01

78

Traumatic Brain Injury Generates Biphasic Hemodynamic ...

The effects on reproductive functions of feeding adult rhesus monkeys on a diet of irradiated wheat flour and potato was investigated. Wheat flour and potatoes were exposed to 75 000 and 10 000 rad, respectively, of #gamma#-irradiation and then fed to the animals. Various parameters of reproductive function were compared with those of animals fed on unirradiated food. These were: external changes in the reproductive organs, menstrual cycle, vaginal cytology, assay of urinary hormones (oestrogens and pregnanediol), and post-mortem histopathological examination of the reproductive organs. At the end of 3 months, the experimental and control animals behaved similarly with regard to their reproductive functions. (author).

79

Titration of diphtheria and tetanus antitoxins in sera of low titre

... animal through a mask by isoflurane and maintained by a balanced anesthesia, which consisted of an intramuscular injection of Innovar-vet (0.11 ...

1993-04-01

80

The role of contagious disease in udder health

Available methods for titrating diphtheria and tetanus antitoxin at low concentrations in human or animal blood are surveyed, with special attention to the amount of serum required for the test....Full Text Available

1971-01-01

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81

The contribution of lower vertebrate animal models in human reproduction research

Contagious diseases are a threat to animal health and productivity, both nationally and at the farm level. This makes implementation of biosecurity measures to prevent their introduction and...Full Text Available

2009-10-01

82

British Library Electronic Table of Contents (United Kingdom)

Many advances have been carried out on the estrogens, GnRH and endocannabinoid system that have impact in the reproductive field. Indeed, estrogens, the generally accepted female hormones, have performed an unsuspected role in male sexual functions thanks to studies on non-mammalian vertebrates. Similarly, these animal models have provided important contributions to the identification of several GnRH ligand and receptor variants and their possible involvement in sexual behavior and gonadal function regulation. Moreover, the use of non-mammalian animal models has contributed to a better comprehension about the endocannabinoid system action in several mammalian reproductive events. We wish to highlight here how non-mammalian vertebrate animal model research contributes to advancements with i...

2011-01-01

83

The Natural Statistics of Audiovisual Speech

Humans, like other animals, are exposed to a continuous stream of signals, which are dynamic, multimodal, extended, and time varying in nature. This complex input space must be transduced and sampled...Full Text Available

2009-07-01

84

Tags ? NASA Astrobiology

Studies of the action of hypoglycin-a, a hypoglycaemic substance

Mar 15, 2010... Boulder have demonstrated that a five-nucleotide-long ribozyme can ... animals anoxia anoxia biomarker permian cambrian terrestrial ...

85

Snow Survey & Water Supply | NRCS

Some biological effects of hypoglycin-A, a compound isolated from the fruit of Blighia sapida, have been investigated. Administration of this compound to animals caused drowsiness...Full Text Available

1958-06-01

86

Simultaneous recognition and segmentation of cells: application in C.elegans

Programs & Services Technical Resources Land Use Soils Water Snow Survey & Water Supply Water Management Water Quality Watersheds Wetlands Air Plants & Animals Energy Climate...

2011-08-21

87

Role of spinal cyclooxygenase in human postoperative and chronic pain

Motivation: Automatic recognition of cell identities is critical for quantitative measurement, targeting and manipulation of cells of model animals at single-cell resolution. It has been...Full Text Available

2011-10-15

88

Reporting Problems to FDA

BackgroundNonsteroidal anti-inflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest these drugs act in part by blocking...Full Text Available

2010-05-01

89

Medline Plus

Enter Search terms A-Z Index Home Food Drugs Medical Devices Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Radiation-Emitting Products Tobacco ...

90

Regulatory T cells in human disease and their potential for therapeutic manipulation

Proteomic strategies in multiple sclerosis and its animal models

Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory...Full Text Available

2006-05-01

91

Possible health effects of working with VDUs.

The early and precise diagnosis, the prognosis, and the clinical management of multiple sclerosis, remain a considerable challenge. In recent years, the development of novel and powerful proteomic...Full Text Available

2007-10-16

92

Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations

A summary of the effects presented here is given in the table. The designation "factor present" implies that there is knowledge (from human or animal studies, or both) of a specific factor(s) present...Full Text Available

1989-04-01

93

Hypothalamic and dietary control of temperature-mediated longevity

BackgroundBisphenol A (BPA) is a high-production-volume chemical commonly used in the manufacture of polycarbonate plastic. Low-level concentrations of BPA in animals and possibly...Full Text Available

2009-09-01

94

Homocysteine and Familial Longevity: The Leiden Longevity Study

Temperature is an important modulator of longevity and aging in both poikilotherms and homeotherm animals. In homeotherms, temperature homeostasis is regulated primarily in the preoptic area...Full Text Available

2010-01-01

95

Handbook of Dangerous Animals for Field Personnel

Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor...Full Text Available

96

Genomics of human longevity

... 110 Page 9. CONTENTS (Continued) Evaluation of Antivenin for Common Cobra (Naja naja) and Blue Krait (Bungarus caeruleus) Venoms I 13 ...

1972-12-01

97

Genomic view of the evolution of the complement system

In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available

2011-01-12

98

Food additives: an ethical evaluation.

The recent accumulation of genomic information of many representative animals has made it possible to trace the evolution of the complement system based on the presence or absence of each complement...Full Text Available

2006-09-01

99

Extreme resistance of bdelloid rotifers to ionizing radiation

Background Food additives are an integral part of the modern food system, but opinion polls showing most Europeans have worries about them imply an urgent need for ethical analysis of their use. Sources of data The existing literature on food ethics, safety assessment and animal testing. Areas of agreement Food additives provide certain advantages in terms of many people's lifestyles. Areas of controversy There are disagreements about the appropriate application of the precautionary principle and of the value and ethical validity of animal tests in assessing human safety. Growing points Most consumers have a poor understanding of the relative benefits and risks of additives, but concerns over food safety and animal testing remain high. Areas timely for developing research Examining the impacts of food additives on consumer sovereignty, consumer health and on animals used in safety testing should allow a ...

2011-07-01

100

Estimation of Human Toxicity From Animal Inhalation Toxicity ...

Rotifers of class Bdelloidea are common invertebrate animals with highly unusual characteristics, including apparently obligate asexuality, the ability to resume reproduction after desiccation at any...Full Text Available

2008-04-01

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101

Estimation of Genetic Parameters for Growth-Related Traits in 9-month Old of Two Korean Abalone Subspecies, Haliotis discus hannai and H. discus discus, by Using Multiple Traits of Animal Model

... Bisgard, GE, Ruiz, AV, Grover, RF & Will, JA, "Ventilatory control in the ... Watkins, BE, Riegle, GD & Heisey, SR, "Respiratory responses to ACTH and ...

1997-10-01

102

KoreaScience (Korea)

Full Text Available

2009-12-01

103

Electromagnetic fields and public health.

Dishonest signalling in a fiddler crab.

A review of the literature is provided for the topic of health-related research and power frequency electromagnetic fields. Minimal evidence for concern is present on the basis of animal and plant research....Full Text Available

1987-11-01

104

Diagnostics of Radionuclides Effects Results

Animal communication theory predicts that low-frequency cheating should be common in generally honest signalling systems. However, perhaps because cheats are designed to go undetected, there are few...Full Text Available

2000-04-07

105

International Science & Technology Center (ISTC)

Development of New Methods and Means of Assessing of Consequences of Radionuclide and Heavy Metal Salt Effect, Criteria of Forecasting Physiological State and Productivity of the Farm Animals under Conditions of Ecological Pollution of Environment

106

Developmentally programmed endoreduplication in animals

Development of a microarray for identification of pathogenic Clostridium species

Development of a fertilized egg into an adult human requires trillions of cell divisions, the vast majority of which duplicate their genome once and only once. Nevertheless, trophoblast giant...Full Text Available

2009-05-15

107

Development of a New Generation of Small Scale Biomass ...

In recent years, Clostridium species have rapidly reemerged as human and animal pathogens. The detection and identification of pathogenic Clostridium species...Full Text Available

2010-02-01

108

Detection of genetic mutations in repetitive DNA sequences in somatic human cells after low-dose irradiation

... power from wood and bagasse as well as convert non-traditional fuel sources such as rice bulls, animal manure, cotton gin trash, straws, and ...

1995-08-01

109

Current Projects - Human Nutrition Research Center on Aging ...

... 3-89701-147-6 0949-2224 245 p. animal cells dna genetic radiation effects

1998-03-01

110

Cottonseed feeding delivers sufficient quantities of gossypol as a male deer contraceptive

diet and genetic obesity metabolic defects and inflammation. To determine the role of adipocyte death in promoting adipose tissue inflammation and insulin resistance in animal...

2011-08-31

111

British Library Electronic Table of Contents (United Kingdom)

To define the quantitative and qualitative effects of gossypol (GP) on deer (Cervus elaphus) semen, the animals were fed cottonseed (CS). Adult stags each received 350?g of CS for 109?days. Animals received 15?mg of gossypol per kilogram body weight per day. Quantitative and qualitative parameters of experimental ejaculates (n?=?182) were compared to ejaculates (n?=?571) of control animals (n?=?5) collected during three previous natural reproductive seasons. Ejaculate fractions were evaluated by classical methods used in domestic animals. In this paper, we show that mature male deer fed CS exhibited morphological changes and decreased motility of spermatozoa and abnormalities in spermatogenesis. Radioimmunoassay measured concentrations of various steroid hormones (T-testosterone, A4-andros...

2008-01-01

112

Considerations on Temperature, Longevity and Aging

A modest reduction in body temperature prolongs longevity and possibly retards aging in both poikilotherm and homeotherm animals. Some of the possible mechanisms mediating these effects are...Full Text Available

2008-06-01

113

Biodiversity of Vibrios

Are animal models predictive for humans?

Vibrios are ubiquitous and abundant in the aquatic environment. A high abundance of vibrios is also detected in tissues and/or organs of various marine algae and animals, e.g., abalones, bivalves, corals,...Full Text Available

2004-09-01

114

Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific...Full Text Available

115

Animal Models for Radiation Injury, Protection and Therapy

The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal...Full Text Available

116

A search for the epidemic typhus agent in Ethiopian ticks*

... radiation during clinical therapy and exposures due to radiation accidents or attacks, in which the doses are uncontrolled ... only be used off-label in victims of radiation accidents or attacks. The idea...

117

Urban epizootic of rabies in Mexico: epidemiology and impact of animal bite injuries.

The presence of antibodies to Rickettsia prowazeki in domestic animals from several parts of Africa, and the isolation of this rickettsia from the blood of goats and sheep and from...Full Text Available

1973-01-01

118

Transfer of Plasmid-Mediated CTX-M-9 from Salmonella enterica Serotype Virchow to Enterobacteriaceae in Human Flora-Associated Rats Treated with Cefixime?

From 1 July 1987 to 31 December 1988, a total of 317 animals (91% of which were dogs) were confirmed to have rabies in Hermosillo, Mexico. The median age of rabid dogs was 1 year, 69% were male, and...Full Text Available

1993-01-01

119

Modalidade de morte em mamiferos expostos a irradiacao de corpo inteiro (sindrome aguda da radiacao). (Modes of death in mammals exposed to whole body radiation (acute radiation syndromes)).

Food animals are a potential source of CTX-M resistance genes for humans. We evaluated the transfer of the bla_CTX-M-9 gene from an animal strain of Salmonella enterica...Full Text Available

2010-01-01

120

Failure of desferrioxamine to modify the toxicity of paraquat in rats

When an animal is exposed to a sufficient amount of radiation, there will be changes in many organs of the body, and as a result of either the effects in one particular organ or the interaction of effects in several organs, the animal as a whole will show...

1990-01-01

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121

Extended-Spectrum-?-Lactamase-Producing Escherichia coli Strains Isolated from Farm Animals from 1999 to 2002: Report from the Japanese Veterinary Antimicrobial Resistance Monitoring Program

The feasibility of using desferrioxamine (DF), an iron chelator, as a therapeutic agent against paraquat (PQ/sup + +/) toxicity in male Sprague-Dawley rats was explored, based on the rationale of limiting toxic hydroxyl radical production from hydrogen peroxide by removing redox-active iron. Body weights, mortality, and lung histopathology were followed for periods up to 14 days after intraperitoneal injection of PQ/sup + +/ (20 or 25 mg/kg body weight) with or without concurrent daily subcutaneous injections of DF (300 mg/day). Animals receiving PQ/sup + +/ showed the expected typical patterns of mortality and of lung histopathology, namely: marked edema, subpleural hemorrhage, acute inflammation, perivascular mononuclear cell infiltrates, sloughing of alveolar and bronchiolar lining cells, and diffuse interstitial fibrosis. Desferrioxamine alone was non-toxic. Surprisingly, results when both PQ/sup + +/ and DF were administered indicated a failure of DF to ...

1985-01-01

122

Biological parameters of transgenic rabbits

A nationwide surveillance for antimicrobial susceptibility in Escherichia coli strains isolated from food-producing animals in Japan was conducted from 1999 to 2002. Eighteen cefazolin-resistant...Full Text Available

2005-08-01

123

British Library Electronic Table of Contents (United Kingdom)

The investigations were conducted at the Center of Biotechnology and Molecular Diagnostics of the All-Russian Animal Husbandry Research Institute, where a number of valuable transgenic animals (rabbits, sheep, and pigs) have been produced over the course of 20 years. The article presents the blood indices of control and transgenic rabbits with an integrated insulin gene.

2011-01-01

124

Development of a methodology to assess organometallic effects on bioenergetic systems

Scale-up of Multidrug-Resistant Tuberculosis Laboratory Services, Peru

A methodology for assessing the impact of subacute concentrations of organometallic agents on bioenergetic and oxidative damage processes in animals, cells and energy transducing subcellular organelles is being developed. Several of the assays are noninvasive and thus lend themselves to human tests. At the whole-animal level we utilize a treadmill chamber where physiological parameters of exercising animals are monitored. These include parameters of whole animals' work performance such as oxygen consumption, carbon dioxide evolution and endurance. Oxidative damage can be monitored in experiments by analyzing expired air of the animals for ethane and n-pentane. These alkanes correlate with lipid peroxidation in vivo. At the cellular and subcellular levels, respiratory activity, lipid peroxidation and free radical species are assayed. Respiratory activity is measured in ...

1981-06-01

125

Coryneform bacteria in infectious diseases: clinical and laboratory aspects.

Over the past 10 years, the Peruvian National Tuberculosis (TB) Program, the National Reference Laboratory (NRL), Socios en Salud, and US partners have worked to strengthen the national TB laboratory...Full Text Available

2008-05-01

126

A conceptual model for laboratory ventilation greenhouse gas planning

Coryneform isolates from clinical specimens frequently cannot be identified by either reference laboratories or research laboratories. Many of these organisms are skin flora that belong to a large number...Full Text Available

1990-07-01

127

British Library Electronic Table of Contents (United Kingdom)

There is increasing pressure to operate laboratory facilities in environmentally and financially sustainable ways. A key factor in achieving this goal is careful consideration of how energy is used by the buildings' ventilation system, both for conditioning air supplied to the laboratories and the energy used moving air through the building. Traditionally, laboratory energy use is treated as an engineering concern within the scope of the building's overall design and operation. However, this approach limits the involvement of key stakeholders in many important decisions and can lead to unexpected safety concerns for the laboratory's users. We believe that a broad view of the parties affected by a laboratory building's operations is necessary to avoid having the various stakeholders working...

2011-01-01

128

Widespread duplications in the genomes of laboratory stocks of Dictyostelium discoideum

Today in History: December 17

BackgroundDuplications of stretches of the genome are an important source of individual genetic variation, but their unrecognized presence in laboratory organisms would be a confounding...Full Text Available

2008-01-01

129

The Laboratory for Research on the Structure of Matter (LRSM...

as manufacturing plants and laboratories, including the Chemical Laboratory at the House of David in Benton Harbor, Michigan. Built in America: Historic Building Buildings Survey/...

2010-12-17

130

Statement of work for analytical services provided by PNNL`sanalytical chemistry laboratory

as one of the first Materials Research Laboratories to be funded by the forerunner of DARPA. In 1972 funding was taken over by the National Science Foundation's Division of...

2011-08-18

131

Savannah River Laboratory monthly report, November 1991

The purpose of this statement of work (SOW) is to establish laboratory analytical criteria and requirements for radioactive airborne emissions measurement sample and/or analysis activities.

1997-06-30

132

Savannah River Laboratory monthly report, November 1991

This document details monthly activities at the Savannah River Laboratory. Topics addressed are reactor operation; tritium facilities and production; separation operations; environmental concerns; and waste management. (FI)

1991-01-01

133

Pigment Analysis by HPLC at Horn Point Laboratory

This document details monthly activities at the Savannah River Laboratory. Topics addressed are reactor operation; tritium facilities and production; separation operations; environmental concerns; and waste management. (FI)

1991-12-31

134

Funding will push battery technology from Argonne Laboratory

Oct 30, 2006 ... Pigment Analysis by HPLC at Horn Point Laboratory. Laurie Van Heukelem. Crystal Thomas. Meg Maddox. University of Maryland Center for ...

135

Interconnected project 'Development and testing of a biological monitoring for effects of polycyclic aromatic hydrocarbons on man'

Publications Science Highlights Researcher Profiles Internship Funding to push battery technology from Argonne Laboratory to marketplace Bookmark and Share (Download...

2011-08-27

136

Influence of weather on the behaviour of outdoor-wintered beef cattle in Scandinavia

The research project had the aim to develop a standard for measuring individual, inner stresses from polycyclic aromatic hydrocarbons (PAHs) at work. The employed method was by characterizing PAHs and metabolites of PAHs to be identified in urine with a view to developing a biological monitoring of professionally exposured persons. Using a number of PAHs relevant to work, the following questions were studied in cell culture systems and different animal-experimental models: Which metabolites are formed from the PAHs used in cell culture systems and the different animal-experimental models, and what are their ratios in percent? What percentage of a PAH is excreted by experimental animals in their urine and faeces on the first, second, and third day following different forms of application? What is the scale of the individual range of variation of PAH mass excretion? Are these results transferable to man? (orig.).

1992-01-01

137

British Library Electronic Table of Contents (United Kingdom)

The aim of the present investigation was to study the effect of weather and available protection on the behaviour of outdoor-wintered beef cattle (Bos taurus). A herd of 78-85 cattle head was studied during four winter months in the Southwest of Sweden. Protection was offered by coniferous forest situated on and around the 12ha pasture, which we divided into protection categories. During 240h we observed 10 cows and 10 heifers as focal animals (each 3h/month) during day time and adjusted observation times to the altitude of the sun. Close to the animals and at an unprotected spot of the pasture we measured temperature, wind speed and solar radiation and combined these variables to a single measure called Wind Chill Temperature (WCT). During observations the animals were in the forest in 12...

2011-01-01

138

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters

British Library Electronic Table of Contents (United Kingdom)

Research on hematological disorders relies on suitable animal models. We retrospectively evaluated the use of the hematological parameters hematocrit (HCT), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), red blood cell count (RBC), white blood cell count (WBC), and platelet count (PLT) in the phenotype-driven Munich N-ethyl-N-nitrosourea (ENU) mouse mutagenesis project as parameters for the generation of novel animal models for human diseases. The analysis was carried out on more than 16,000 G1 and G3 offspring of chemically mutagenized inbred C3H mice to detect dominant and recessive mutations leading to deviations in the levels of the chosen parameters. Identification of animals exhibiting altered valu...

2011-01-01

139

Exploration of the hypothalamic?pituitary?adrenal function as a tool to evaluate animal welfare

British Library Electronic Table of Contents (United Kingdom)

Measuring HPA axis activity is the standard approach to the study of stress and welfare in farm animals. Although the reference technique is the use of blood plasma to measure glucocorticoid hormones (cortisol or corticosterone), several alternative methods such as the measurement of corticosteroids in saliva, urine or faeces have been developed to overcome the stress induced by blood sampling itself. In chronic stress situations, as is frequently the case in studies about farm animal welfare, hormonal secretions are usually unchanged but dynamic testing allows the demonstration of functional changes at several levels of the system, including the sensitization of the adrenal cortex to ACTH and the resistance of the axis to feedback inhibition by corticosteroids (dexamethasone suppression t...

2007-01-01

140

Experimental bovine trypanosomiasis. Changes in serum immunoglobulins, complement and complement components in infected animals.

Effects of swimming training at the intensity equivalent to aerobic/anaerobic metabolic transition in alloxan diabetic rats

In three calves experimentally infected with Trypanosoma congolense the amounts of IgG1 and IgG2 were little changed and similar to those of normal animals. IgM increased in amount early in the infection and the amount of the increase appeared related to the parasite burden. The amounts of IgA and IgE were both much decreased and this also appeared related to the numbers of parasites in the blood. There was a decrease in the amounts of total haemolytic complement and complement components C1, C1q and C3 in the infected calves. Furthermore the amounts of properdin fluctuated with the cyclical changes in numbers of T. congolense parasites in the individual calves. No significant change in the amount of C8 was observed. It is considered that activation of both the alternative and the classical complement pathways occurs in trypanosome infected animals but that neither pathway goes to its terminal stages.

1978-11-01

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141

British Library Electronic Table of Contents (United Kingdom)

The present study was designed to determine the exercise intensity equivalent to the metabolic aerobic/anaerobic transition of alloxan diabetic rats, through lactate minimum test (LMT), and to evaluate the effects of swimming exercise at this intensity (LM) on the glucose and protein metabolism of these animals. Adult male Wistar rats received alloxan (SD, alloxan-injected rats that remained sedentary) intravenously (30 mg kg?1 body weight) for diabetes induction. As controls (SC, vehicle-injected rats that remained sedentary), vehicle-injected rats were utilized. Two weeks later, the animals were submitted to oral glucose tolerance test (oGTT) and LMT. After the tests, some of the animals were submitted to swimming exercise training [TC (vehicle-injected rats that performed a 6-week exerc...

2007-01-01

142

Effects of burrow condition and seed handling time on hoarding strategies of Edward's long-tailed rat (Leopoldamys edwardsi)

British Library Electronic Table of Contents (United Kingdom)

Many hoarding rodents use burrows not only for dwelling and protection from natural enemies, but also for food storage. However, little is known how burrows used by scatter-hoarding animals influence their foraging behaviors. In addition, handling time for a given food item has a fundamental impact on hoarding strategies of these hoarding animals: food items with longer handling time are more likely to be hoarded due to increasing predation risk because the animals spend more time outside their burrows if they consumed such food. By providing with two types of artificial burrows (aboveground vs. underground) and two types of food items (i.e. seeds) with contrasting handling times, we investigated how burrow condition and handling time co-influence hoarding strategies of a key scatter-hoard...

2010-01-01

143

Volatilization of fluorides from solid uranium(IV)fluoride

Role of congenital rubella reference laboratory: 21-months-surveillance in Liguria, Italy.

... deposition evaporation fission products fluorides iodine 134 laboratory

1971-02-01

144

Mobile laboratory for controlling and monitoring atmospheric pollution

PMID:20812517

2009-12-01

145

MANAGING WASTE AT LOS ALAMOS NATIONAL LABORATORY'S PLUTONIUM FACILITIES

Short communication. 1 ref., 4 figs.

146

Interstellar PAH Analogs in the Laboratory: Comparison with Astronomical Data

No abstract prepared.

2000-01-01

147

FY2003 Laboratory Directed Research and Development Program Annual Report

Polycyclic Aromatic Hydrocarbons (PAHs) are an important and ubiquitous component of carbon-bearing

2005-01-01

148

Automated transport and sorting system in a large reference laboratory: part 1. Evaluation of needs and alternatives and development of a plan.

No abstract prepared.

2004-07-30

149

PMID:12324492

2002-10-01

150

'__-_ _! _/_/ _

In 1963, Grover and co-workers at the Los Alamos. Scientific. Laboratory ...... and A. P. Watkins. (1986) "The Computation of Compressible ...

151

Zoonoses-With Friends Like This, Who Needs Enemies?

Health surveillance program This article outlines the principal components of quality control of laboratory rodents.

1986-02-01

152

X-ray structure of sensory rhodopsin II at 2.1-? resolution

Zoonoses are infections that are spread from animals to humans. Most often, humans are “dead-end” hosts, meaning that there is no subsequent human-to-human transmission. If one considers...Full Text Available

2008-01-01

153

Watchdog Calls on USDA to Boost Transparency in Organic Governance

Sensory rhodopsins (SRs) belong to a subfamily of heptahelical transmembrane proteins containing a retinal chromophore. These photoreceptors mediate the cascade of vision in animal eyes and phototaxis...Full Text Available

2001-08-28

154

Visually Mediated Odor Tracking During Flight in Drosophila

...qualified and who were under consideration at the time, USDA Secretary Tom Vilsack chose an animal husbandry specialist employed by one of the largest organic livestock product marketers in the country. While this appointee had grown up on a conventional farm, her immediate occupation is not that of ...

155

Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans

Flying insects use visual cues to stabilize their heading in a wind stream. Many animals additionally track odors carried in the wind. As such, visual stabilization of upwind tracking directly aids...Full Text Available

156

Two Proline-Rich Nuclear Localization Signals in the Amino- and Carboxyl-Terminal Regions of the Borna Disease Virus Phosphoprotein

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers...Full Text Available

2011-04-01

157

Torpor induction in mammals: Recent discoveries fueling new ideas

Borna disease virus (BDV) uses a unique strategy of replication and transcription which takes place in the nucleus, unlike other known, nonsegmented, negative-stranded RNA viruses of animal origin....Full Text Available

1998-12-01

158

The pharmacology and molecular mechanisms underlying temperature regulation and torpor

When faced with a harsh climate or inadequate food, some mammals enter a state of suspended animation known as torpor. A major goal of torpor research is to determine mechanisms that integrate...Full Text Available

2009-12-01

159

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

The ability to enter a hypometabolic state upon restriction of caloric intake is pivotal for animal survival: balancing the energy budget in endotherms can be a real struggle when food is not...Full Text Available

2008-10-01

160

The complete mitochondrial genome of the stomatopod crustacean Squilla mantis

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through...Full Text Available

2011-01-12

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161

The Potential Use of Electricity to Control Burrowing Shrimp in Oyster Aquaculture Beds

BackgroundAnimal mitochondrial genomes are physically separate from the much larger nuclear genomes and have proven useful both for phylogenetic studies and for understanding genome...Full Text Available

162

The Mitochondrial Isovaleryl-Coenzyme A Dehydrogenase of Arabidopsis Oxidizes Intermediates of Leucine and Valine Catabolism1

Thalassinid shrimp cause significant problems for oyster aquaculture in the Pacific Northwest (USA) where oysters succumb to the physical disruption of the sediment by the burrowing activity of these animals. While electrofishing is a commonly used technique to capture fish and some invertebrates i...

163

Testing game theory models: fighting ability and decision rules in chameleon contests

We recently identified a cDNA encoding a putative isovaleryl-coenzyme A (CoA) dehydrogenase in Arabidopsis (AtIVD). In animals, this homotetrameric enzyme is located in mitochondria and catalyzes the...Full Text Available

2001-06-01

164

Sustained metabolic scope.

Game theory models of animal contests make many non-mutually exclusive predictions, complicating empirical tests. These predictions regard the relationship between contest parameters and fighting ability,...Full Text Available

2006-06-22

165

Study on upgrading of oil palm wastes to animal feeds by radiation and fermentation processing

Sustained metabolic rates (SusMR) are time-averaged metabolic rates that are measured in free-ranging animals maintaining constant body mass over periods long enough that metabolism is fueled by food...Full Text Available

1990-03-01

166

Stress and Stress-Induced Neuroendocrine Changes Increase the Susceptibility of Juvenile Oysters (Crassostrea gigas) to Vibrio splendidus

Upgrading of oil palm empty fruit bunch (EFB), which is a main by-product of palm oil industry, to animal feeds by radiation pasteurization and fermentation was investigated for recycling the agro-resources and reducing the environmental pollution. The following results were obtained: 1) The necessary dose for pasteurization of EFB contaminated by various microorganisms including aflatoxin producing fungi was determined as 10 kGy. The chemical and biological properties of EFB were changed little by irradiation up to 50 kGy. 2) In the fermentation process, Pleurotus sajor-caju was selected as the most effective fungi and the optimum condition for fermentation was clarified. The process of fermentation in suspension was also established for the liquid seed preparation. 3) The digestibility and nutritional value of fermented products were evaluated as ruminant animal feeds and the mushroom can be produced as by-product. 4) The pilot plant named ...

2002-10-15

167

Stable isotopes document the trophic structure of a deep-sea cephalopod assemblage including giant octopod and giant squid

Oysters are permanently exposed to various microbes, and their defense system is continuously solicited to prevent accumulation of invading and pathogenic organisms. Therefore, impairment of the animal's...Full Text Available

2001-05-01

168

Although deep-sea cephalopods are key marine organims, their feeding ecology remains essentially unknown. Here, we report for the first time the trophic structure of an assemblage of these animals (19...Full Text Available

2009-06-23

169

Some food toxic for pets

Shiga Toxin Subtypes Display Dramatic Differences in Potency ?

According to world statistics, dogs and cats are the species that owners most frequently seek assistance with potential poisonings, accounting 95–98% of all reported animal cases. Exposures...Full Text Available

2009-09-01

170

Scaling of swim speed and stroke frequency in geometrically similar penguins: they swim optimally to minimize cost of transport

Purified Shiga toxin (Stx) alone is capable of producing systemic complications, including hemolytic-uremic syndrome (HUS), in animal models of disease. Stx includes two major antigenic forms (Stx1...Full Text Available

2011-03-01

171

Scaling of offspring number and mass to plant and animal size: model and meta-analysis

It has been predicted that geometrically similar animals would swim at the same speed with stroke frequency scaling with mass^−1/3. In the present study, morphological and behavioural...Full Text Available

2010-03-07

172

Salmonellosis in Botswana

The scaling of reproductive parameters to body size is important for understanding ecological and evolutionary patterns. Here, we derived allometric relationships for the number and mass of seeds, eggs...Full Text Available

2008-04-01

173

Clinical salmonellosis in cattle is infrequently recorded in Botswana, the majority of salmonella isolations being made from apparently healthy animals. A salmonella carrier rate of 6·7% was...Full Text Available

1971-09-01

174

STR References 3001-3250

SG Report on Harmony with Nature final single-spaced.doc

Journal of Human Genetics. 82: 873-882. 3134. Schulz, I., Schneider, P. M., Olek, K, Rothschild, M. A., and Tsokos, M. (2006) Examination of Postmortem Animal Interference to Human...

2009-03-16

175

Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels

of early humanitarians, and the vivisectors turned to Rene Descartes (1596 1650 ) to justify ...A celebrated mathematician, physiologist, and psychologist, Descartes provided a general philosophy of the irrelevance of ethics to the ...Animals, according to Descartes, were insensible and irrational machines; moved, like clocks, but

176

Relations between respiratory symptoms and sickness among workers in the animal feed industry.

Phosphatidic acid (PA) is postulated to have both structural and signaling functions during membrane dynamics in animal cells. In this study, we show that before a critical time period during rhabdomere...Full Text Available

2009-04-06

177

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

OBJECTIVE--The survey aimed at studying the associations between prevalent respiratory symptoms in an occupational population and sickness absence due to respiratory disorders. METHODS--A cross sectional...Full Text Available

1994-07-01

178

Receptor mechanisms and dose-response models for the effects of dioxins.

The effects of homologous plasma HDL and VHDL fractions on established atherosclerotic lesions were studied in cholesterol-fed rabbits. Atherosclerosis was induced by feeding the animals a 0.5% cholesterol-rich...Full Text Available

1990-04-01

179

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

There is increasing evidence that receptor-mediated events impact one or more stages responsible for tumor development in experimental animals and humans. Although many chemicals and endogenous hormones...Full Text Available

1993-04-22

180

Prenatal cocaine reduces AMPA receptor synaptic expression through hyperphosphorylation of the synaptic anchoring protein GRIP

Failures in cortical control of fronto-striatal neural circuits may underpin impulsive and compulsive acts. In this narrative review, we explore these behaviors from the perspective of neural processes...Full Text Available

2010-02-01

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181

Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity

Prenatal cocaine exposure produces sustained neurobehavioral and brain synaptic changes closely resembling those of animals with defective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic...Full Text Available

2009-05-13

182

Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites.

How transcription factors interpret the cis-regulatory logic encoded within enhancers to mediate quantitative changes in spatiotemporally restricted expression patterns during animal...Full Text Available

2010-05-15

183

Physiologic Responses to Infrarenal Aortic Cross-Clamping during Laparoscopic or Conventional Vascular Surgery in Experimental Animal Model: Comparative Study

Trichloroethylene (TCE) pharmacokinetics have been studied in experimental animals and humans for over 30 years. Compartmental and physiologically based pharmacokinetic (PBPK) models have been developed...Full Text Available

2000-05-01

184

Pathophysiological, Genetic and Gene Expression Features of a Novel Rodent Model of the Cardio-Metabolic Syndrome

The aim of this study was to compare the hemodynamic and ventilatory effects of prolonged infrarenal aortic cross-clamping in pigs undergoing either laparotomy or laparoscopy. 18 pigs were used for...Full Text Available

2008-01-01

185

Parallels between playbacks and Pleistocene tar seeps suggest sociality in an extinct sabretooth cat, Smilodon

BackgroundComplex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models.Methodology/Principal...Full Text Available

186

Outbreak of acute colitis on a horse farm associated with tetracycline-contaminated sweet feed.

Inferences concerning the lives of extinct animals are difficult to obtain from the fossil record. Here we present a novel approach to the study of extinct carnivores, using a comparison between fossil...Full Text Available

2009-02-23

187

On the function of the mammalian renal papilla and the peristalsis of the surrounding pelvis

Exposure of a group of horses to tetracycline-contaminated feed resulted in acute colitis and subsequent death in one horse and milder diarrhea in 3 others. The most severely affected animal demonstrated...Full Text Available

1999-10-01

188

Nuclear reprogramming in mammalian somatic cell nuclear cloning

This is an informal personal review of the development over time of my ideas about the concentrating mechanism of the mammalian renal papilla. It had been observed that animals with a need to produce...Full Text Available

2011-07-01

189

Novel Analogs and Stereoisomers of the Marine Toxin Neodysiherbaine with Specificity for Kainate Receptors

Nuclear cloning is still a developing technique used to create genetically identical animals by somatic cell nuclear transfer into unfertilized eggs. Despite an intensive effort in a number...Full Text Available

2004-01-01

190

Naturally occurring double-stranded RNA and immune responses. III. Immunogenicity and antigenicity in animals.

Antagonists for kainate receptors (KARs), a family of glutamate-gated ion channels, are efficacious in a number of animal models of neuropathologies, including epilepsy, migraine pain, and anxiety....Full Text Available

2008-02-01

191

Monitoring of Tumor Promotion and Progression in a Mouse Model of Inflammation-Induced Colon Cancer with Magnetic Resonance Colonography1

Naturally occurring, double-stranded RNA (ds-RNA)) was immunogenic when injected into mice, rats, guinea-pigs, rabbits, dogs and baboons. The response to native material administered intravenously (i.v.)...Full Text Available

1975-12-01

192

Mitochondrial DNA Damage and Animal Longevity: Insights from Comparative Studies

Early detection of precancerous tissue has significantly improved survival of most cancers including colorectal cancer (CRC). Animal models designed to study the early stages of cancer are valuable...Full Text Available

2009-03-01

193

Mechanical strain enhances survivability of collagen micronetworks in the presence of collagenase: implications for load-bearing matrix growth and stability

Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. However, uncontrolled and potentially deleterious endogenous reactions occur,...Full Text Available

194

Massive turnover of functional sequence in human and other mammalian genomes

There has been great interest in understanding the methods by which collagen-based load-bearing tissue is constructed, grown and maintained in vertebrate animals. To date, the responsibility for this...Full Text Available

2009-09-13

195

Major evolutionary transitions in ant agriculture

Despite the availability of dozens of animal genome sequences, two key questions remain unanswered: First, what fraction of any species' genome confers biological function, and second, are apparent...Full Text Available

2010-10-01

196

Longitudinal assessment of lung cancer progression in the mouse using in vivo micro-CT imaging

Agriculture is a specialized form of symbiosis that is known to have evolved in only four animal groups: humans, bark beetles, termites, and ants. Here, we reconstruct the major evolutionary transitions...Full Text Available

2008-04-08

197

Life history consequences of growth variation

Purpose: Small animal micro-CT imaging is being used increasingly in preclinical biomedical research to provide phenotypic descriptions of genomic models. Most of this imaging is coincident...Full Text Available

2010-09-01

198

Knockout of Arabidopsis ACCELERATED-CELL-DEATH11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense

ObjectivesThe main objective of this study is to address the following specific questions: 1. Are the delayed effects of poor early diet on whole organism performance and senescence contingent on, or exacerbated by, the subsequent occurrence of compensatory growth? 2. Does the rate of growth influence levels of resting metabolism and/or oxidative stress, and if so, for how long does this persist? 3. How are the levels of early nutrition, growth, resting metabolism and oxidative stress linked to the lev [continued...]DescriptionIt is now widely appreciated that, while animals may appear to recover from periods of poor food quality or quantity experienced in early development, adverse effects may occur later in adult life. Such effects can influence the performance of complete cohorts of animals, and have important consequences for population dynamics. The reasons why such delayed effects occur across the animals' lifetimes ...

2009-01-30

199

Isolation of BAC Clones Containing Conserved Genes from Libraries of Three Distantly Related Moths: A Useful Resource for Comparative Genomics of Lepidoptera

We describe the lethal, recessive accelerated-cell-death11 Arabidopsis mutant (acd11). Cell death in acd11 exhibits characteristics of animal apoptosis...Full Text Available

2002-02-15

200

Inheritable Effect of Unpredictable Maternal Separation on Behavioral Responses in Mice

Lepidoptera, butterflies and moths, is the second largest animal order and includes numerous agricultural pests. To facilitate comparative genomics in Lepidoptera, we isolated BAC clones containing...Full Text Available

2011-01-01

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201

Influence of parasite strain on chemotherapy of murine infections with schistosomiasis mansoni

The long-term impact of early stress on behavior and emotions is well documented in humans, and can be modeled in experimental animals. In mice, maternal separation during early postnatal development...Full Text Available

202

Influence of murine leukemia proviral integrations on development of N-methyl-N-nitrosourea-induced thymic lymphomas in AKR mice.

The effectiveness of chemotherapy in human schistosomiasis varies from one area to another, and limited data from experimentally infected animals suggest inherent differences in the susceptibility...Full Text Available

1971-01-01

203

Importance of pollinators in changing landscapes for world crops

The AKR mouse strain is characterized by a high incidence of spontaneous thymic lymphoma that appears in older animals (greater than 6 months of age) and is associated with novel provirus integrations...Full Text Available

1991-11-01

204

Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays.

The extent of our reliance on animal pollination for world crop production for human food has not previously been evaluated and the previous estimates for countries or continents have seldom used primary...Full Text Available

2007-02-07

205

ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine

Environmental chemicals that function as estrogens have been suggested to be associated with an increase in disease and dysfunctions in animals and humans. To characterize chemicals that may act as...Full Text Available

1996-10-01

206

Hyperoxia enhances VEGF release from A549 cells via post-transcriptional processes

BackgroundAnimals carrying genetic mutations have provided powerful insights into the role of interstitial cells of Cajal (ICC) in motility. One classic model is...Full Text Available

2010-05-01

207

Hunting at the highway: traffic noise reduces foraging efficiency in acoustic predators

Exposure of animals to hyperoxia decreases lung VEGF mRNA expression concomitant with an acute increase in VEGF protein within the epithelial lining fluid (ELF). The VEGF concentration in ELF...Full Text Available

2007-09-01

208

Hsp12.6 Expression Is Inducible by Host Immunity in Adult Worms of the Parasitic Nematode Nippostrongylus brasiliensis

Noise pollution from human traffic networks and industrial activity impacts vast areas of our planet. While anthropogenic noise effects on animal communication are well documented, we have very limited...Full Text Available

2011-06-07

209

High stimulus specificity characterizes anti-predator habituation under natural conditions

Heat shock proteins (Hsp) are a family of stress-inducible molecular chaperones that play multiple roles in a wide variety of animals. However, the roles of Hsps in parasitic nematodes remain largely...Full Text Available

210

Health effects of air pollutants: sulfuric acid, the old and the new.

Habituation is one of the most fundamental learning processes that allow animals to adapt to dynamic environments. It is ubiquitous and often thought of as a simple form of non-associative learning....Full Text Available

2009-12-22

211

Gonadal hormones modulate sex differences in judgments of relative numerousness in meadow voles, Microtus pennsylvanicus

Data from exposure of experimental animals and human subjects to sulfuric acid presents a consistent picture of its toxicology. Effects on airway resistance in asthmatic subjects were well predicted...Full Text Available

1989-05-01

212

Glossary - Helmholtz-Centre for Environmental Research - UFZ - Research for the environment

Animals in a variety of taxa discriminate between a greater quantity and a lesser quantity of the same object, an ability that is referred to as relative numerousness judgment. For example,...Full Text Available

2009-01-01

213

Genotyping faecal samples of Bengal tiger Panthera tigris tigris for population estimation: A pilot study

... Contrary to this definition, abiotic environmental factors are those in which no organisms participate - e.g. the geological underground, light, temperature and heat. Biotope The biotope is an area of uniform environmental conditions providing living place for a specific assemblage of plants and animals....

214

Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens

BackgroundBengal tiger Panthera tigris tigris the National Animal of India, is an endangered species. Estimating populations for such species is the main objective...Full Text Available

215

Genome-Wide Identification and Evolutionary Analysis of the Animal Specific ETS Transcription Factor Family

The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered....Full Text Available

2009-03-01

216

Genetic association between the COMT genotype and urinary levels of tea polyphenols and their metabolites among daily green tea drinkers

The ETS proteins are a family of transcription factors (TFs) that regulate a variety of biological processes. We made genome-wide analyses to explore the classification of the ETS gene family. We identified...Full Text Available

217

Gender and risk of autoimmune diseases: possible role of estrogenic compounds.

Available in vitro and animal studies have shown cancer protective effects of tea polyphenols. Recent study suggests a greater protective effect of green tea intake on breast cancer...Full Text Available

218

Fatty Acid- and Retinoid-binding Proteins Have Distinct Binding Pockets for the Two Types of Cargo*

A striking common feature of many autoimmune diseases in humans and experimental animals, despite differences in pathology, is that females are highly susceptible to autoimmune conditions compared to...Full Text Available

1999-10-01

219

Evolution of Thermal Response Properties in a Cold-Activated TRP Channel

Parasitic nematodes cause serious diseases in humans, animals, and plants. They have limited lipid metabolism and are reliant on lipid-binding proteins to acquire these metabolites from their hosts....Full Text Available

2009-12-18

220

Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells

Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show...Full Text Available

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221

Evaluation of Tumor Micro-Environment in an Animal Model using a Nanoparticle Contrast Agent in Computed Tomography Imaging

Hematopoietic stem cells replenish all the cells of the blood throughout the lifetime of an animal. Although thousands of stem cells reside in the bone marrow, only a few contribute to blood production...Full Text Available

2006-09-01

222

Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester

RATIONALE AND OBJECTIVESNon-invasive longitudinal imaging of tumor vasculature could provide new insights into the development of solid tumors, facilitating efficient...Full Text Available

2011-01-01

223

Epigenetic Therapies for Chemoresensitization of Epithelial Ovarian Cancer

Phenylpropenes such as chavicol, t-anol, eugenol, and isoeugenol are produced by plants as defense compounds against animals and microorganisms and as floral attractants of pollinators....Full Text Available

2006-06-27

224

Efficacy of antimicrobial therapy in experimental rat pneumonia: effects of impaired phagocytosis.

SummaryEpigenetic drugs have been shown to enhance gene expression and drug sensitivity in ovarian cancer cell lines and animal models. Based on promising pre-clinical studies,...Full Text Available

2010-02-01

225

Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease

The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy...Full Text Available

1979-07-01

226

Early auditory experience generates long-lasting memories that may subserve vocal learning in songbirds

The effects of dietary monosodium glutamate (MSG) on trans-fatty acid (TFA)-induced nonalcoholic fatty liver disease (NAFLD) are addressed in an animal model. We used Affymetrix microarray...Full Text Available

2009-08-01

227

Display of Recombinant Proteins on Bacillus subtilis Spores, Using a Coat-Associated Enzyme as the Carrier?

In both humans and songbirds, infants learn vocalizations by imitating the sounds of adult tutors with whom they interact during an early sensitive period. Vocal learning occurs in few animal taxa;...Full Text Available

2006-01-24

228

Developmental plasticity and the evolution of animal complex life cycles

The display of proteins such as feed enzymes at the surface of bacterial spore systems has a great potential use for animal feed. Feed enzymes increase the digestibility of nutrients, leading to greater...Full Text Available

2010-09-01

229

Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.

Metazoan life cycles can be complex in different ways. A number of diverse phenotypes and reproductive events can sequentially occur along the cycle, and at certain stages a variety of developmental...Full Text Available

2010-02-27

230

Coordinated and Cohesive Movement of Two Small Conspecific Fish Induced by Eliciting a Simultaneous Optomotor Response

Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes...Full Text Available

2000-06-01

231

Conjugated linoleic acid modulation of risk factors associated with atherosclerosis

BackgroundIn animal groups such as herds, schools, and flocks, a certain distance is maintained between adjacent individuals, allowing them to move as a cohesive unit. Proximate...Full Text Available

232

Comparison of ante-mortem assays to assess progression/regression of paratuberculosis in individual dairy animals

Conjugated linoleic acid (CLA) has been the subject of extensive investigation regarding its possible benefits on a variety of human diseases. In some animal studies, CLA has been shown to have a beneficial...Full Text Available

233

Clostridium perfringens Delta Toxin Is Sequence Related to Beta Toxin, NetB, and Staphylococcus Pore-Forming Toxins, but Shows Functional Differences

Johne disease, caused by Mycobacterium avium, subspecies paratuberculosis (MAP) is becoming increasingly widespread on dairy farms worldwide, due in part, to the absence...Full Text Available

2010-05-01

234

Circadian Disruption and Metabolic Disease: Findings from Animal Models

Clostridium perfringens produces numerous toxins, which are responsible for severe diseases in man and animals. Delta toxin is one of the three hemolysins released by a number of C....Full Text Available

235

Chondroitin sulphate structure affects its immunological activities on murine splenocytes sensitized with ovalbumin

Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors...Full Text Available

2010-10-01

236

Chemical structure and inhalation toxicity of lipopolysaccharides from bacteria on cotton.

Chondroitin sulphate (CS) is a glycosaminoglycan widely distributed in animal tissues, which has anti-inflammatory and chondroprotective properties. We reported previously that chondroitin 4-sulphate...Full Text Available

2004-08-15

237

Chemical carcinogenesis: too many rodent carcinogens.

Lipopolysaccharides from different bacteria isolated from cotton were purified and chemically analyzed. Their pulmonary toxicity to animals was tested in inhalation tests. Lipopolysaccharides from Agrobacterium...Full Text Available

1980-09-01

238

Characterization of Toxin Plasmids in Clostridium perfringens Type C Isolates?

The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis...Full Text Available

1990-10-01

239

Central gating of fly optomotor response

Clostridium perfringens type C isolates cause enteritis necroticans in humans or necrotizing enteritis and enterotoxemia in domestic animals. Type C isolates always produce alpha toxin...Full Text Available

2010-11-01

240

Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II

We study the integration of multisensory and central input at the level of an identified fly motoneuron, the ventral cervical nerve motoneuron (VCNM) cell, which controls head movements of the animal....Full Text Available

2010-11-16

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241

Biologic Rhythms Derived from Siberian Mammoths' Hairs

Cytokinesis in animal and fungal cells utilizes a contractile actomyosin ring (AMR). However, how myosin II is targeted to the division site and promotes AMR assembly, and how the AMR coordinates with...Full Text Available

2010-12-27

242

Beneficial Effect of a Short-Acting NO Donor for the Prevention of Neointimal Hyperplasia

Hair is preserved for millennia in permafrost; it enshrines a record of biologic rhythms and offers a glimpse at chronobiology as it was in extinct animals. Here we compare biologic rhythms gleaned...Full Text Available

243

Behavioral consequences of dopamine deficiency in the Drosophila central nervous system

Nitric oxide (NO)-based therapies effectively inhibit neointimal hyperplasia in animal models of arterial injury and bypass grafting, but are not available clinically. We created a simple, effective,...Full Text Available

2008-01-01

244

Associations between the clinical signs of chronic endometritis with ovarian cysts and body condition loss in German Holstein Friesian cows

The neuromodulatory function of dopamine (DA) is an inherent feature of nervous systems of all animals. To learn more about the function of neural DA in Drosophila, we generated mutant...Full Text Available

2011-01-11

245

Assessing phytoremediation potentials of selected tropical plants for acrylamide

The objective of this retrospective field study was to associate the type and smell of discharge, the size of the uterus, the ovarian and treatment status, and the time to diagnosis of animals with...Full Text Available

2009-12-01

246

Arabidopsis thaliana Chromosome 4 Replicates in Two Phases That Correlate with Chromatin State

In biotechnology, acrylamide is being used in DNA and RNA analysis using the polyacrylamide gel electrophoreses procedure. Polymerized acrylamide is degraded into acrylamide through time; it is converted into a hazardous contaminant that is carcinogenic and neurotoxic to animals and humans. Because ...

247

Animal and human studies of a new /sup 99m/Tc labelled phosphine-isocyanide complex with possible applications to radionuclide ventriculography

DNA replication programs have been studied extensively in yeast and animal systems, where they have been shown to correlate with gene expression and certain epigenetic modifications. Despite the conservation...Full Text Available

2010-06-01

248

Animal Models in Carotenoids Research and Lung Cancer Prevention1

A new /sup 99m/Tc-phosphine-isocyanide complex with the general structure (/sup 99m/Tc (DEPE)/sub 2/(CNR)/sub 2/)/sup +/ has been synthesised and tested in animals and one human. In three animal species (rat, rabbit, dog), the complex is an efficient myocardial imaging agent, while in humans it remains in the blood pool. The complex is 100% protein bound in animals and humans, but whereas in humans it is attached to a 51.5 kdalton protein (probably prealbumin), in rabbits it appears to be bound to a larger macromolecule (M.W.>100 kdalton). The efficiency of the complex for blood pool labelling was tested in a human volunteer and compared with the standard in vivo red cell labelling technique with stannous pyrophosphate. A satisfactory radionuclide angiogram could be performed with less than 370 MBq of the complex. The count rate for the complex (cps/MBq) was 15% higher than that obtained with the labelled red cells and ...

1987-04-01

249

Analysis of the Pharmacokinetic Interaction between Cephalexin and Quinapril by a Nonlinear Mixed-Effect Model

Numerous epidemiological studies have consistently demonstrated that individuals who eat more fruits and vegetables (which are rich in carotenoids) and who have higher serum β-carotene levels...Full Text Available

250

An initial comparative map of copy number variations in the goat (Capra hircus) genome

Oligopeptidic drugs such as β-lactams and angiotensin-converting enzyme inhibitors share the same carriers in humans and animals, which results in possible pharmacokinetic interactions. To model...Full Text Available

1998-06-01

251

An argument for the chicken embryo as a model for the developmental toxicological effects of the polyhalogenated aromatic hydrocarbons (PHAHs)

BackgroundThe goat (Capra hircus) represents one of the most important farm animal species. It is reared in all continents with an estimated world population of...Full Text Available

252

An Intrinsic Neuronal Oscillator Underlies Dopaminergic Neuron Bursting

This article will present the argument that the chicken embryo is especially appropriate as an animal model for studying the mechanism of the developmental toxicological effects of the polyhalogenated aromatic hydrocarbons (PHAHs). The PHAHs are a group of toxicologically related compounds including, in part, the polychlorinated dibenzodioxins, dibenzofurans and biphenyls. The chicken (Gallus gallus) embryo is relatively sensitive to the toxicological effects of the PHAHs being approximately two orders of magnitude more sensitive than the mature bird. The chicken embryo has been used to demonstrate general toxicological teratogeneicity, hepatotoxicity and neurotoxicity. Many of these effects, or analogous effects, have also been observed in mammals and fish. Thus, most animals appear to respond to the PHAHs with a similar toxicological profile, indicating that many of the biomarkers used for the PHAHs are valid across a number of species, ...

1996-12-31

253

Allometry of visceral organs in living amniotes and its implications for sauropod dinosaurs

Dopaminergic neurons of the ventral midbrain fire high frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can...Full Text Available

2009-12-16

254

Acamprosate and naltrexone treatment effects on ethanol and sucrose seeking and intake in ethanol-dependent and nondependent rats

Allometric equations are often used to extrapolate traits in animals for which only body mass estimates are known, such as dinosaurs. One important decision can be whether these equations should be...Full Text Available

2009-05-07

255

A Novel Mouse Model of Red Blood Cell Storage and Post-Transfusion in Vivo Survival

RationaleTwo pharmacotherapies are approved for treating alcohol craving (acamprosate and naltrexone), but both have shown mixed findings in animals and humans.Full Text Available

2009-06-01

256

A Meta-Analysis of Animal Studies on Disruption of Spatial Navigation by Prenatal Cocaine Exposure

BackgroundStorage of RBCs is necessary for an adequate blood supply. However, reports have identified potential negative sequelae of transfusing stored RBCs. An animal...Full Text Available

2009-08-01

257

A Dominant Role for the Immunoproteasome in CD8⁺ T Cell Responses to Murine Cytomegalovirus

Water-maze testing has been used to assess prenatal cocaine (PCOC)- induced deficits in behavioral studies of spatial navigation and memory abilities. Effects of PCOC in acquisition or in probe...Full Text Available

2007-01-01

258

32 CFR 935.40 - Criminal offenses.

Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates...Full Text Available

259

32 CFR 935.150 - Registration.

... (v) Import onto or keep on Wake Island any plant or animal not indigenous to the island, other than military working dogs or a guide dog for the blind or visually-impaired accompanying its owner; or (w) Import or bring onto or...

2010-07-01

260

...1) A privately owned motor vehicle. (2) A privately owned boat. (3) An indigenous animal, military working dog, or guide dog for the blind or visually-impaired accompanying its owner. (4) A narcotic or dangerous drug or...

2010-07-01

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261

27na4

Oak Ridge National Laboratory Review: Volume 24, No. 2, 1991

by American scientists, ecosystems containing a greater number of plant species, produce more biomass.This result ...to meet the increasing demand for land for farmland planted with monocultures, buildings and roads.For ...have hypothesized that greater ecological diversity (diversity of plant and animal species) leads to a greater

262

Laboratory robotics projects in the Analytical Development Division at the Savannah River Laboratory

The Oak Ridge National Laboratory (ORNL) is a multiprogram, multipurpose laboratory that conducts research in the physical, chemical, and life sciences; in fusion, fission, and fossil energy; and in energy conservation and other energy-related technologies. This review outlines some current endeavors of the lab. A state of the laboratory presentation is given by director, Alvin Trivelpiece. Research of single crystals for welding is described. The Science Alliance, a partnership between ORNL and the University of Tennessee, is chronicled. And several incites into distinguished personnel at the laboratory are given. (GHH)

1991-01-01

263

[The simulation of 137Cs distribution in forest ecosystems and prediction of its accumulation by forest products].

To encourage the application of robotics technology for routine radiobench applications, a laboratory dedicated to the research and development of contained robotic systems is being constructed. The facility will have several robots located in laminar flow hoods, and the hoods are being designed to allow the possibility for multiple robots to work together. This paper presents both the design features of the hoods and the general layout of the laboratory, and also discusses an application of a robotic system for the routine nuclear counting of gamma tube samples. The gamma tube system is presently operating in one of the routine analysis laboratories. 5 figs.

264

The impact of intensive and extensive rearing environment on mucosal immunity in the piglet (GUTWEAN)

A mathematical model of 137Cs migration in forest ecosystem is presented, which describes the behaviour of this radionuclide in the forest litter-soil system, trees, understory and forest animals. The model's parameters for different types of forest ecosystems are estimated and model's adequacy is tested through the use of independent experimental data. The sensitivity of the model's output variables is analyzed to variations in the most significant parameters. The differences in the seasonal and mean annual dynamics of 137Cs concentration in muscles of roe deers and mooses are shown to be defined by specific features of the diets of these animals and variations in 137Cs content in the main diet components. PMID:11402557

265

Nondestructive analysis for "2"3"2U and decay progeny in animal tissues

DescriptionPig production represents an important source of revenue for the agricultural industry of the UK. However as a direct result of environmental and animal welfare concerns European-wide directives are now in place which severely restrict both the non-clinical use of production enhancers/chemotherapeutics and heavy metals in animal production and also prevent piglet weaning prior to 28 days of age. These legislative events have had a major impact on pig production within Europe rendering current pr [continued...

2009-01-31

266

Lithium isotopes: differential effects in animals

Direct determination of "2"3"2U and its decay products in animal tissues appears to be feasible using an intrinsic Ge(Li) diode detector (for energies of 5-100 keV) and a NaI(Tl) anticoincidence-shielded Ge(Li) diode for higher-energy gamma photons. The detection sensitivity for "2"3"2U and "2"2"8Th is 0.03 and 0.01 nCi, respectively, using a 300-min counting time.

1977-05-01

267

Effect of protein malnutrition on the metabolism of bone collagen in albino rats

Differences in the biological disposition and in the effects of the stable lithium isotopes, Li-6 and Li-7, in animals were characterized. A somewhat higher toxicity was associated with WLiCl compared to XLiCl with NLiCl intermediate. All lithium treatments increased water intake and resulted in weight gain. Peak plasma concentration was slightly high for 6Li than 7LiCl suppressed action potential amplitudes during tetanic stimulation more than NaCl when added to Renger solution bathing ganglia.

1984-04-01

268

Estimation of animal and olive solid wastes in Jordan and their potential as a supplementary energy source: An overview

The effect of protein malnutrition on the metabolism of collagen in bone was studied in young female albino rats after a single injection of "3H-proline. Both specific and total radioactivities of hydroxyproline in the total collagen of the bone were found to decrease in the protein-deficient animals, indicating decreased rate of collagen synthesis. In the urine the amount of hydroxyproline excreted and total radioactivity of "3H-hydroxyproline were greatly decreased. The results of the present investigation therefore clearly indicate decreased synthesis and catabolism of collagen in bones of protein deficient animals compared to controls. (auth.).

1981-01-01

269

Quality assurance handbook for measurement laboratories

Biomass is a potential source of energy that can reduce our dependency on oil as the main source of energy. In addition to municipal solid waste, animal and olive wastes are the main sources of organic waste in Jordan. In 2005, there were more than 2.4 million heads of sheep, about 72 thousand cows, and 40 million hens being raised in farms distributed in all governorates of Jordan. These animals produce 5.3 million tons (as exerted) of solid waste per year. If these quantities can be effectively collected they may constitute a valuable source of energy. This paper is aiming to estimate the amounts of animal and solid wastes generated in Jordan and their energy potential. The total amount of BOD from animal waste is estimated at 200,000 tons per year. Significant quantities of organic waste can also be collected from olive mills distributed in the country. This waste known locally as ...

2010-10-15

270

Laboratory directed research and development program, FY 1996

This handbook provides guidance in the application of quality assurance to measurement activities. It is intended to help those persons making measurements in applying quality assurance to their work activities by showing how laboratory practices and quality assurance requirements are integrated to provide control within those activities. The use of the guidance found in this handbook should help provide consistency in the interpretation of quality assurance requirements across all types of measurement laboratories. This handbook also can assist quality assurance personnel in understanding the relationships between laboratory practices and quality assurance requirements. The handbook is composed of three chapters and several appendices. Basic guidance is provided by the three chapters. In Chapter 1, the role of quality assurance in obtaining quality data and the importance of such data are discussed. Chapter 2 presents the ...

271

OSHA Hazardous-Chemical Occupational Exposure Standard for laboratories: A new management regulation to ensure employee health. Final report

The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab) Laboratory Directed Research and Development Program FY 1996 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development (LDRD) program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The Berkeley Lab LDRD program is a critical tool for directing the Laboratory`s forefront scientific research capabilities toward vital, excellent, and emerging scientific challenges. The program provides the resources for Berkeley Lab scientists to make rapid and significant contributions to critical national science and technology problems. The LDRD program also ...

1997-02-01

272

Surge Capacity for Response to Bioterrorism in Hospital Clinical Microbiology Laboratories

The OSHA's chemical occupational exposure standard for laboratories is an outgrowth of the previously issued Hazard Communication Standard. The standard relieves laboratories from complying with general industry standards but does not require compliance with specific guidelines. The heart of the standard is the creation of a Chemical Hygiene Plan (CHP) in every laboratory. The CHP addresses major issues such as safety equipment and procedures, work practices and training, the designation of a chemical hygiene officer, and the provision of medical consultation and examination for affected employees. This new standard, in effect as of 31 January, 1991, presents yet another regulatory challenge to laboratory managers but also will ensure a safer work environment for laboratory workers.

1991-04-01

273

Status of the Lawrence Berkeley Laboratory and Lawrence Livermore National Laboratory free electron laser (FEL)

Surge capacity is the ability to rapidly mobilize to meet an increased demand. While large amounts of federal funding have been allocated to public health laboratories, little federal funding has been...Full Text Available

2003-12-01

274

Regulatory compliance | Mott MacDonald

A description of the FEL experiment underway at the 10 kA, 5 MeV Experimental Test Accelerator (ETA) is described. The facility has been designed to investigate the high-gain operation of an FEL.

1983-09-19

275

Recommissioning and first operation of the CWDD injector at Argonne National Laboratory

...broad range of experience in designing and building research and development laboratories for products such as vaccines, blood and sera, biological products, medical devices, solid dosage forms , highly potent products and cytotoxic material. We also have experience in a range of modular laboratories for TSE research, ...

276

Plasmid Transfer between Bacillus thuringiensis subsp. israelensis Strains in Laboratory Culture, River Water, and Dipteran Larvae

The CWDD injector has been shipped to Argonne National Laboratory, installed, and recommissioned. Commissioning progress, operational status, and future plans are reported. Operational experience at ANL is compared with that obtained at Culham.

1992-12-31

277

Oak Ridge National Laboratory Technology Logic Diagram. Volume 2, Technology Logic Diagram: Part C, Waste Management

Plasmid transfer between strains of Bacillus thuringiensis subsp. israelensis was studied under a range of environmentally relevant laboratory conditions in vitro,...Full Text Available

2001-01-01

278

Laboratory simulation of a deep-ocean in-situ heat-transfer experiment

This report documents site remediation at ORNL, including ORNL site characterization technologies, waste management and robotics and automation of the laboratory for waste processing and analysis.

1993-09-01

279

Laboratory simulation of a deep-ocean in-situ heat-transfer experiment

The Subseabed Disposal Program has recently completed a 30-day, 0.286-scale laboratory simulation of an In Situ Heat Transfer Experiment (ISHTE), scheduled for eventual deployment in the deep ocean 600 nautical miles north of Hawaii. 10 figures.

1982-01-01

280

Laboratory Evaluation of Base Materials for Neutralization of the Contaminated Aquifer at the F-Area Seepage Basins

The Subseabed Disposal Program has recently completed a 30-day, 0.286-scale laboratory simulation of an In Situ Heat Transfer Experiment (ISHTE), scheduled for eventual deployment in the deep ocean 600 nautical miles north of Hawaii. 10 figures.

1982-09-22

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281

Interaction effects of ethanol and pyrazole in laboratory rodents

Laboratory studies were performed to support field-testing of base injection into the F-Area Seepage Basins groundwater. The general purpose of these experiments is to provide information to guide the test of base injection and to identify potential adverse effects.

2001-09-11

282

Information Technology Laboratory Homepage

1. Interactions of pyrazole and ethanol were studied in three laboratory test procedures. They included sleeping time in mice, rotor rod balance in rats and lever pressing behaviour of rats. 2....Full Text Available

1971-09-01

283

Draft Strategic Laboratory Missions Plan. Volume II

NIST logo NIST Time NIST Home About NIST Contact Us A-Z Site Index Search Information Technology Laboratory About ITL What ITL does Organization ITL Functional Statement Standards...

2011-08-04

284

Clinical pathology accreditation: standards for the medical laboratory

This volume described in detail the Department's research and technology development activities and their funding at the Department's laboratories. It includes 166 Mission Activity Profiles, organized by major mission area, with each representing a discrete budget function called a Budget and Reporting (B ampersand R) Code. The activities profiled here encompass the total research and technology development funding of the laboratories from the Department. Each profile includes a description of the activity and shows how the funding for that activity is distributed among the DOE laboratories as well as universities and industry. The profiles also indicate the principal laboratories for each activity, as well as which other laboratories are involved. The information in this volume is at the core of the Strategic Laboratory Mission Plan. It enables a reader to ...

2004-06-07

285

Clinical and laboratory studies in patients with leprosy and enthesitis.

This article describes a new set of revised standards for the medical laboratory, which have been produced by Clinical Pathology Accreditation (UK) Ltd (CPA). The original standards have been in use...Full Text Available

2002-10-01

286

Augmenting Clinical Evaluation of Hemiparetic Arm Movement With a Laboratory-Based Quantitative Measurement of Kinematics as a Function of Limb Loading

In a combined clinical, radiological, and laboratory study of 77 patients throughout the leprosy spectrum, 10 patients had an enthesitis which has not been described previously as far as is known and...Full Text Available

1990-09-01

287

222-S Laboratory maintenance implementation plan

BackgroundKinematic and kinetic measurements used in laboratory settings can quantify upper extremity movement impairment following stroke, but their relationship...Full Text Available

2008-01-01

288

Variations in humanized and defined culture conditions supporting derivation of new human embryonic stem cell lines

This Maintenance Improvement Plan has been developed for maintenance functions associated with the 222-S Laboratory. This plan is developed from the guidelines presented by Department of Energy (DOE) Order 4330.4B, Maintenance Management Program (DOE 1994), Chapter 11. The objective of this plan is to provide information for establishing and identifying WMH conformance programs and policies applicable to implementation of DOE Order 4330.4B guidelines. In addition, this maintenance plan identifies the actions necessary to develop a cost effective and efficient maintenance program at 222-S Laboratory. Maintenance activities are mainly going to be performed by existing maintenance organizations within Waste Management Federal Services of Hanford (WMH). Most maintenance performed at 222-S Laboratory is performed by the 222-S Laboratory maintenance organization. This 222-S Laboratory ...

1997-08-13

289

DEFF Research Database (Denmark)

The evolution of "humanized" (i.e., free of animal sourced reagents) and ultimately chemically defined culture systems for human embryo stem cell (hESC) isolation and culture is of importance to improving their efficacy and safety in research and therapeutic applications. This can be achieved by integration of a multitude of individual approaches to replace or eliminate specific animal sourced reagents into a single comprehensive protocol. In the present study our objective was to integrate strategies obviating reliance on some of the most poorly defined and path-critical factors associated with hESC derivation, namely the use of animal immune compliment to isolate embryo inner cell mass, and animal sourced serum products and feeder cells to sustain hESC growth and attachment. As a result we report the derivation of six new hESC lines isolated by outgrowth from whole blastocysts on an extracellular ...

2006-01-01

290

Source tracking of Escherichia coli by 16S-23S intergenic spacer region denaturing gradient gel electrophoresis (DGGE) of the rrnB ribosomal operon.

Percutaneous osseointegrated prostheses for amputees: Limb compensation in a 12-month ovine model.

This research validates a novel approach for source tracking based on denaturing gradient gel electrophoresis (DGGE) analysis of DNA extracted from Escherichia coli isolates. Escherichia coli from different animal sources and from river samples upstream from, at, and downstream of a combined sewer overflow were subjected to DGGE to determine sequence variations within the 16S-23S intergenic spacer region (ISR) of the rrnB ribosomal operon. The ISR was analyzed to determine if E. coli isolates from various animal sources could be differentiated from each other. DNA isolated from the E. coli animal sources was PCR amplified to isolate the rrnB operon. To prevent amplification of all 7 E. coli ribosomal operons by PCR amplification using universal primers, sequence-specific primers were utilized for the rrnB operon. Another primer set was then used to prepare samples of the 16S-23S ISR for DGGE. Comparison of PCR-DGGE results ...

2007-10-01

291

Comparison of internal emitter radiobiology in animals and humans

Percutaneous osseointegrated prostheses are being investigated as an alternative strategy to attach prosthetic limbs to patients. Although the use of these implants has shown to be promising in clinical trials, the ability to maintain a skin seal around an osseointegrated implant interface is a major challenge to prevent superficial and deep periprosthetic infections. The specific aim of this study was to establish a translational load-bearing ovine model to assess postoperative limb compensation and gait symmetry following a percutaneous osseointegrated implant. We tested the following hypotheses: (1) the animals would return to pre-amputation limb loads within 12-months; (2) the animals would return to a symmetrical gait pattern (stride length and time in stance) within 12-months. The results demonstrated that one month following surgery, the sheep loaded their amputated limb to a mean value of nearly 80% of their pre-amputation loading ...

2011-09-13

292

Untitled - NASA Technical Report Server (NTRS)

Investigations of radionuclide metabolism and effects in various mammalian species revealed important similarities between animals and humans and between some animal species. These include skeletal deposition of radium and radiostrontium in bone volume; deposition on bone surfaces of plutonium and other actinides; liver deposition of actinides; induction of skeletal or liver malignancies by these radionuclides; induction of tooth and jaw abnormalities; mammary cancer induction by radium in humans and in the beagle; depression of circulating cells in blood; and induction of bone fractures. There are also inter-species differences that may not have been noted if multiple species (including humans) had not been studied. Some of these are more rapid excretion of radium in humans compared with most other mammals; induction by radium of eye melanomas in animals but not humans; rapid loss of deposited plutonium from liver in many ...

1997-01-01

293

The use of the isotope "3"2P in the study of some ecological aspects of a laboratory stream ecosystem

Directional audio technology for headphone applications is being developed. A laboratory demonstration model of a real-time digital ...

294

PROCEEDINGS OF ELECTRIC INITIATOR SYMPOSIUM. ...

A laboratory stream consisting of two stream sections interrupted by two pools was filled with a mixture of tap water and organically enriched water from rivers nearby. Bottom sediment material, Potamogeton pectinatus, macro-invertebrate organisms, as well as the mosquito fish, Aplocheilichthys johnstonii were collected from rivers around Johannesburg and introduced into the laboratory stream. After initial acclimatization, the distribution of the isotope "3"2P through this laboratory stream was followed. Absorption of this isotope by benthic algae, Potamogeton pectinatus, several macro-invertebrate organisms as well as Aplocheilichthys johnstonii was recorded.

295

Operational Constraints on the Utility of Virtual Audio Cueing

... 5. EXPLODING BRIDGEWIRE INITIATION OF RDX WITH 50 MILLIJOUUS RM Hillyer, Naval Ordnance Laboratory, Corona, Calif. .... ...

1963-10-01

296

Los Alamos National Laboratory's Hydrogeologic Studies of the Pajarito Plateau: A Synthesis of Hydrogeologic Workplan Activities (1998--2004)

... conditions. the Air Force Research Laboratory's Aural Displays and The advent of virtual audio technology provides as many ...

1999-09-01

297

Flip-flop sequence for restoring Zeeman order in the laboratory reference frame

No abstract prepared.

2005-12-13

298

FY2000 Annual Self-Evaluation Report for the Pacific Northwest National Laboratory

... spin-lattice relaxation angular momentum electronic circuits magnetic

299

FAST LABORATORY DIAGNOSIS BY MEANS OF ...

Annual report of performance against FY2000 performance evaluation and fee aggreement.

2000-11-15

300

Energy and Water Conservation

... negative diplooocci, to determine the type of pneumococi, to study staphylococa proteas, ehigla, sallmnefla, pasteurella, brucela, linters, leptosp ,s ...

1963-05-07

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Effect of milling conditions on stress corrosion cracking generation sensitivity of low carbon stainless steel

Jet Propulsion Laboratory. California Institute of Technology. Pasadena, California. Energy and Water Conservation. Steve Rigdon. Facilities Energy Manager ...

302

Distribution Models for Optical Scintillation Due to ...

... Industry, Material Science Research Laboratory, Yokosuka, Kanagawa (Japan)

2009-09-01

303

Aviation Maintenance Safety Articles, January/February 1990

... Lincoln Laboratory Distribution Models for Optical Scintillation Due to Atmospheric Turbulence RR Parenti RJ Susiela Group 107 ...

2005-12-12

304

... These are abnormal and an indication of NAVAIRINST 13340.3 identifies these laboratories a possible breakdown in the fuel-handling equip- ...

1990-02-01

305

Annual report, 1979-1980

Accelerated aging tests for radiation degradation of organic materials

Information is presented concerning reactor research activities; isotope geology; NERC radiocarbon laboratory; teaching activities; and reactor operation.

1980-01-01

306

Optical Fiber Sensors from Laboratory to Field Trials: Applications and Trends at CEA LIST

(Jun 1984). United States Clough, RL Gillen, KT Sandia Nat'l Laboratories

1984-06-03

307

British Library Electronic Table of Contents (United Kingdom)

Fiber optic metrology developed at the CEA LIST laboratories involves fiber Bragg grating sensors, distributed Brillouin optical time domain reflectometry and optically stimulated luminescence dosimetry. Recent activities in optical fiber sensing are reviewed from laboratory experiments to field trials.

2009-01-01

308

Industrial ecology at Lawrence Livermore National Laboratory summary statement

Image-enhancement applications at the Lawrence Livermore National Laboratory

This statement summarizes Lawrence Livermore National Laboratory`s committment to making important scientific, technological, and business contributions to global sustainability. The quest has many aspects, some socio-political or economic and some technological, and some in which the soft and hard sciences become indistinguishable, as in visionary national strategies, like Holland`s, and futuristic regional and city development plans, like those of Kagoshima and Chattanooga.

1996-05-21

309

Health and Safety Research Division progress report for the period October 1, 1991--March 31, 1993

A diverse set of digital image-processing applications exists at the Lawrence Livermore National Laboratory. While many of these include some sort of image analysis or restoration, virtually all of them require image-enhancement procedures. In this paper we describe the principal image-processing facility at the Laboratory, followed by a discussion of several of the major image-processing application areas.

1982-06-01

310

Zoonotic Bartonella Species in Fleas and Blood from Red Foxes in Australia.

This is a progress report from the Health and Safety Research Division of Oak Ridge National Laboratory. Information is presented in the following sections: Assessment Technology, Biological and Radiation Physics, Chemical Physics, Biomedical and Environmental Information Analysis, Risk Analysis, Center for Risk Management, Associate Laboratories for Excellence in Radiation Technology (ALERT), and Contributions to National and Lead Laboratory Programs and Assignments--Environmental Restoration.

1998-06-01

311

Study of the reproductive efficiency of dual purpose cattle in Panama through the use of radioimmunoassay techniques

Abstract Bartonella are arthropod-borne, fastidious, Gram-negative, and aerobic bacilli distributed by fleas, lice, sand flies, and, possibly, ticks. The zoonotic Bartonella species, Bartonella henselae and Bartonella clarridgeiae, which are the causes of cat scratch disease and endocarditis in humans, have been reported from cats, cat fleas, and humans in Australia. However, to date, there has been no report of B. henselae or B. clarridgeiae in Australian wild animals and their ectoparasites. B. henselae and B. clarridgeiae were detected in fleas (Ctenocephalides felis) from red foxes (Vulpes vulpes), an introduced pest animal species in Australia, and only B. clarridgeiae was detected in blood from one red fox. Phylogenetic analysis of the ribosomal intergenic spacer region revealed that the B. henselae detected in the current study were related to B. henselae strain Houston-1, a major pathogenic strain in humans in Australia, and confirmed ...

2011-09-15

312

Reduction in radiation-induced brain injury by use of pentobarbital or lidocaine protection

Reproductive parameters were monitored in 50 post-partum Bos indicus x Bos taurus animals located on four farms in two ecological zones of Panama. Progesterone (P_4) concentrations were measured in four of these animals twice a week and their reproductive organs palpated per rectum once a week until 60 days post-artificial-insemination or post-natural-service. The other 46 cows were palpated for early pregnancy between days 45 and 60 post-service. The mean P_4 concentration in cows with palpable corpora lutea (CL) was 10.3#+-#4.0 nmol/L; when no Cl were detected, the mean P_4 level was 2.2#+-#1.6 nmol/L. Of the 46 animals palpated for early pregnancy, 36 (70%) were found to be pregnant, one (2%) exhibited early embryonic death and one (2%) aborted; the other eight cows (17%) were anoestrous. The mean P_4 concentration in pregnant cows was 11.9#+-#4.0 nmol/L and the calving to conception interval was 148 days. (author). 13 ...

313

Radioimmunoassay determination of the effect on animal reproduction of alternative of feeding suplementation in dairy cows

To determine if barbiturates would protect brain at high doses of radiation, survival rates in rats that received whole-brain x-irradiation during pentobarbital- or lidocaine-induced anesthesia were compared with those of control animals that received no medication and of animals anesthetized with ketamine. The animals were shielded so that respiratory and digestive tissues would not be damaged by the radiation. Survival rates in rats that received whole-brain irradiation as a single 7500-rad dose under pentobarbital- or lidocaine-induced anesthesia was increased from between from 0% and 20% to between 45% and 69% over the 40 days of observation compared with the other two groups (p less than 0.007). Ketamine anesthesia provided no protection. There were no notable differential effects upon non-neural tissues, suggesting that pentobarbital afforded protection through modulation of ambient neural activity during radiation ...

1990-05-01

314

Prospects for controlling animal parasitic nematodes by predacious micro fungi.

The principal object of this trial was to evaluate the influence of three alternatives of feeding suplementation in dairy cows in the post-partum period in ecuadorian highlands. Thirty sic animals in fist lactation were used in this experiment and were divided in three groups according to the feed intake: Group A diet was 5 Kg. of a commercial concentrate mixture with 12 per cent of crude protein plus pasture ad libitum; Group B diet was green banans (Musa paradisiaca) and pasture and Group C diet was the control only pasture. Using Radioimmunoassay technique (RIA), progesterone values were determinated in milk from each cow. the sampling was sequential, two samples a week, starting 6 days after parturition, until the animal was pregnant or until the study was finished, 150 days after post-partum for each cow. This research allowed us to evaluate the ovaric post-partum activity of each group: Frequency and length of the oestrus cycles; ...

315

On the stability of Innovar, a neuroleptic analgesic, for cardiovascular experiments.

Resistance against anthelmintics is widespread, particularly in parasitic nematode populations of small ruminants. Several new techniques or supplements have been developed or are under investigation. Biological control (BC) is one of these new methods. The net-trapping predacious fungus Duddingtonia flagrans produces thick walled resting spores, chlamydospores, which are able to survive passage through the gastrointestinal tract of cattle, horses, sheep and pigs. Under Danish climatic conditions it has been shown that the number of parasite larvae on pasture and the worm burden of the grazing animals is significantly reduced when animals are fed spores during the initial 2-3 months of the grazing season. Work with D. flagrans in France, Australia, USA, and Mexico has confirmed the strong BC potential of this fungus. Today much work is going into development of suitable delivery systems for grazing livestock worldwide. Ultimately, BC should be ...

2000-01-01

316

Interconnected project 'Development and testing of a biological monitoring for effects of polycyclic aromatic hydrocarbons on man'. Final report. Verbundprojekt Entwicklung und Erprobung biologischer Ueberwachungsmethoden (Biological Monitoring) bei der Einwirkung von polycyklischen aromatischen Kohlenwasserstoffen auf den Menschen. Abschlussbericht

The effects of 0.2 and 0.5 mL/kg Innovar (a neuroleptic analgesic) on cardiovascular functions and reflexes in rabbits were measured. We recorded the effects of Innovar on arterial pressure, heart rate, respiration rate, ventricular contractility, arterial oxygen tension, as well as the drug's effects on the bradycardia and vasoconstrictor response to cigarette smoke stimulation of the nose (the so-called "nasopharyngeal reflex"). In animals given 0.2 mL/kg Innovar, all steady state cardiovascular variables had returned to pre-Innovar levels in 45 min, as had the efficacy of the nasopharyngeal reflex. In animals given 0.5 mL/kg Innovar, all steady state cardiovascular variables, except PaO2, were slightly but significantly depressed for up to 135 min after injection. The nasopharyngeal reflex returned to normal within 90 min. Because of the calmative and analgesic effects of Innovar, and its only moderate effects on cardiovascular functions and ...

1981-11-01

317

Behavioural evidence for mental time travel in nonhuman animals.

The research project had the aim to develop a standard for measuring individual, inner stresses from polycyclic aromatic hydrocarbons (PAHs) at work. The employed method was by characterizing PAHs and metabolites of PAHs to be identified in urine with a view to developing a biological monitoring of professionally exposured persons. Using a number of PAHs relevant to work, the following questions were studied in cell culture systems and different animal-experimental models: Which metabolites are formed from the PAHs used in cell culture systems and the different animal-experimental models, and what are their ratios in percent What percentage of a PAH is excreted by experimental animals in their urine and faeces on the first, second, and third day following different forms of application What is the scale of the individual range of variation of PAH mass excretion Are these results transferable to man (orig.).

1992-01-01

318

Hazardous-waste disposal and the clinical laboratory. Final report, May-December 1989

If episodic memory is an adaptation, it must have evolved to benefit present or future survival and reproduction, rather than to provide an accurate record of the past per se. Recent research has documented various links between the ability to construct episodes of the past and imagine potential future episodes, and it has been argued that the former may be a design feature of the latter. Thus, claims about the existence of episodic memory in non-verbal organisms may be evaluated by examining behavioural evidence for foresight. Here we review recent data on foresight in animals and conclude that the evidence to suggest episodic memory so far is equivocal. We suggest specific experimental criteria that could provide stronger evidence. We maintain that there must be uniquely human traits for which there are no animal models and it remains possible that mental time travel depends on several such traits. Identification of what precisely is unique ...

2009-12-03

319

FY2000 Annual Self-Evaluation Report for the Pacific Northwest National Laboratory

Negligent hazardous waste management has resulted in real threats to public health. The Federal Government has responded to the situation with laws and regulations aimed at the producers of hazardous waste, including clinical laboratories. The Resources Conservation and Recovery Act (RCRA) imposes controls on hazardous waste management through the Code of Federal Regulations (CFR). The Environmental Protection Agency (EPA) and the Department of Transportation (DOT) regulate these activities through 40 CFR and 49 CFR. Most clinical laboratories can operate satellite accumulation points and accumulate, store, transport, and dispose of waste in accordance with EPA and DOT regulations. Regulations pertaining to infectious waste, sure to affect many clinical laboratories, are being developed now by he EPA. The cradle to grave tracking system mandated by the Federal Government can be supplemented by state and local authorities ...

1990-01-01

320

Trophoblast deportation part II: A review of the maternal consequences of trophoblast deportation

This self-evaluation report offers a summary of results from FY2000 actions to achieve Pacific Northwest National Laboratory's strategy and provides an analysis of the state of their self-assessment process. The result of their integrated planning and assessment process identifies Laboratory strengths and opportunities for improvement. Critical elements of that process are included in this report; namely, a high-level summary of external oversight activities, progress against Operations Improvement Initiatives, and a summary of Laboratory strengths and areas for improvement developed by management from across the laboratory. Some key areas targeted for improvement in FY2001 are: systems approach to resource management; information protection; integrated safety management flow-down to the benchtop; cost management; integrated assessment; Price Anderson Amendments Act (PAAA) Program; and travel ...

2000-11-15

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

British Library Electronic Table of Contents (United Kingdom)

The deportation of trophoblast debris from the placenta was first documented over 100 years ago, and today we know that the deported material ranges from multinucleated syncytial knots/sprouts to trophoblast-derived nanoparticles. However little is known about the effect of trophoblast debris on maternal physiology since it is difficult to investigate these effects in vivo in women. Animal models have been reported but they have provided relatively little information. Most of our current knowledge regarding the effects of trophoblast debris on maternal systems is provided by studies using trophoblast debris obtained from in vitro models of the human placenta. Herein we review the animal models and the in vitro studies, which, between them, suggest that deported trophoblast material may pla...

2011-01-01

322

The Terra Nova oil field development

Radium concentration factors and their use in health and environmental risk assessment

Before expanding on the development of the Terra Nova oilfield, the author discussed the overall business strategy of Petro-Canada and identified where the Terra Nova and offshore Newfoundland oil have their place within this strategy. The principal basins and oilfields offshore Newfoundland were reviewed, then the emphasis shifted to rest on the Terra Nova development project. A whole range of topics were brought up, including the Floating Production, Storage and Offloading (FPSO) facility, the modules layout, the FPSO located at Bull Arm, and the floating production systems. The physical environment of the Grand Banks was highlighted, and the next few sections were devoted to the Terra Nova FPSO, FPSO and drill centres, the Turret General Arrangement, and Spider buoy including the disconnect/reconnect. The last four sections dealt with the animation of riser movement, the wellhead protection animation, Henry Goodrich, and operations ...

2001-07-01

323

Radium concentration factors and their use in health and environmental risk assessment

Radium is known to be taken up by aquatic animals, and tends to accumulate in bone, shell and exoskeleton. The most common approach to estimating the uptake of a radionuclide by aquatic animals for use in health and environmental risk assessments is the concentration factor method. The concentration factor method relates the concentration of a contaminant in an organism to the concentration in the surrounding water. Site specific data are not usually available, and generic, default values are often used in risk assessment studies. This paper describes the concentration factor method, summarizes some of the variables which may influence the concentration factor for radium, reviews reported concentration factors measured in marine environments and presents concentration factors derived from data collected in a study in coastal Louisiana. The use of generic default values for the concentration factor is also discussed.

1991-01-01

324

Pyridostigmine interaction with soman during chronic exposure in rodents. Interim report, February-November 1987

Radium is known to be taken up by aquatic animals, and tends to accumulate in bone, shell and exoskeleton. The most common approach to estimating the uptake of a radionuclide by aquatic animals for use in health and environmental risk assessments is the concentration factor method. The concentration factor method relates the concentration of a contaminant in an organism to the concentration in the surrounding water. Site specific data are not usually available, and generic, default values are often used in risk assessment studies. This paper describes the concentration factor method, summarizes some of the variables which may influence the concentration factor for radium, reviews reported concentration factors measured in marine environments and presents concentration factors derived from data collected in a study in coastal Louisiana. The use of generic default values for the concentration factor is also discussed.

1991-12-31

325

Prolonged Blood Storage Does Not Effect Survival in an Animal Model of Hemorrhagic Shock

The effects of repeated low-level nerve agent exposure on animal performance and lethality are a major concern of USAF Medical Research. This concern has generated interest in the role that pretreatment drugs such as pyridostigmine may play during simultaneous exposure to soman. This role was investigated by recording lethality, weights, symptoms, and cholinesterase (ChE) inhibition in rats chronically exposed to 4 levels of soman (32, 39, 48 or 59 micrograms/kg/day) while simultaneously receiving 10.0 milligrams/kg/day pyridostigmine, 1.0 milligrams/kg/day pyridostigmine, or vehicle via an osmotic pump. No effect (either protective or detractive) was found in the soman-poisoned animals due to the presence or absence of pyridostigmine. However, rat blood biochemistry is different from that of the primate, warranting further study in the primate before extrapolation to man.

1988-01-01

326

British Library Electronic Table of Contents (United Kingdom)

Summary Background: Red blood cell (RBC) transfusion in hemorrhagic shock is life saving. However, several clinical trials have shown that blood transfusion in the critically ill patient might be associated with adverse outcomes. Furthermore, an association between prolonged blood storage and adverse effects of RBC transfusion has been postulated. The aim of this study is to examine the effect of blood storage time on resuscitation outcome, in an animal model of hemorrhagic shock. Methods: 20 Wistar rats were phlebotomized in order to induce reversible hemorrhagic shock. Half of them were resuscitated with blood stored for a short period of time (4 days), and the other ones were resuscitated with blood stored for a prolonged time (14 days). Blood samples for hemoglobin, pH, lactate, bicarb...

2011-01-01

327

Physiological changes in rats after exposure to low levels of microwaves

People of the ancient rainforest: Late Pleistocene foragers at the Batadomba-lena rockshelter, Sri Lanka

The effects of exposure to sublethal levels of microwaves were studied. Young albino rats of both sexes were exposed for 60 days to 7.5-GHz microwaves (1.0-KHz square wave modulation, average power 0.6 mW/cm2) for 3 h daily. During and after microwave exposure several physiological parameters were measured in both control and exposed animals. It was found that the animals exposed to microwaves tended to eat and drink less and thus showed a smaller gain in body weight. Some of the hematological parameters and organ weights were also significantly different. It is proposed that a nonspecific stress response due to microwave exposure and mediated through the central nervous system is responsible for the observed physiological changes.

1990-08-01

328

British Library Electronic Table of Contents (United Kingdom)

Batadomba-lena, a rockshelter in the rainforest of southwestern Sri Lanka, has yielded some of the earliest evidence of Homo sapiens in South Asia. H. sapiens foragers were present at Batadomba-lena from ca. 36,000 cal BP to the terminal Pleistocene and Holocene. Human occupation was sporadic before the global Last Glacial Maximum (LGM). Batadomba-lena's Late Pleistocene inhabitants foraged for a broad spectrum of plant and mainly arboreal animal resources (monkeys, squirrels and abundant rainforest snails), derived from a landscape that retained equatorial rainforest cover through periods of pronounced regional aridity during the LGM. Juxtaposed hearths, palaeofloors with habitation debris, postholes, excavated pits, and animal and plant remains, including abundant Canarium nutshells, ref...

2011-01-01

329

Parallel architecture for rapid image generation and analysis

Nuclear techniques for measuring moisture content in soil profiles

A multiprocessor architecture inspired by the Disney multiplane camera is proposed. For many applications, this approach produces a natural mapping of processors to objects in a scene. Such a mapping promotes parallelism and reduces the hidden-surface work with minimal interprocessor communication and low-overhead cost. Existing graphics architectures store the final picture as a monolithic entity. The architecture here stores each object's image separately. It assembles the final composite picture from component images only when the video display needs to be refreshed. This organization simplifies the work required to animate moving objects that occlude other objects. In addition, the architecture has multiple processors that generate the component images in parallel. This further shortens the time needed to create a composite picture. In addition to generating images for animation, the architecture has the ability to decompose ...

1987-01-01

330

Molecular identification of blood source animals from black flies (Diptera: Simuliidae) collected in the alpine regions of Japan

The prevailing severe shortage of animal feed in most of the developing countries could, to a considerable extent, be overcome through improved range management, which includes introduction of high yielding drought-resistant forage crops, development of adequate water conservation measures, and as far as possible growing annual forage crops on part of the vast areas of arable land currently left fallow each year. Year round measurements are essential for a good understanding of soil water and nutrients dynamics, which allow for adequate evaluation of pasture management alternatives. The methods most commonly used for moisture measurements in soil profiles are discussed because such measurements are likely to form an essential part of any investigation aimed at increasing animal feed production through the development of adequate pasture management practices. (author).

331

British Library Electronic Table of Contents (United Kingdom)

One of vector-borne avian protozoa, Leucocytozoon lovati, has been found in the Japanese rock ptarmigans (Lagopus mutus japonicus), the endangered bird species distributed in the alpine regions in Japan. Vector arthropod species of L. lovati has also been estimated as Simuliidae black flies distributed in the same habitat of the host bird, however, possible blood meals of the black flies were not identified yet. To reveal host animals of black flies, we estimated the blood resources by using molecular techniques. Black flies were collected at Mt. Chogatake, one of the alpine regions of Japan in which Japanese rock ptarmigans live in June 2005. The analyzed 144 specimens were morphologically identified into five species including Simulium japonicum (n?=?87), Prosimulium hirtipes (n?=?48), P...

2010-01-01

332

Lung cancer in rats exposed to fibrogenic dusts

Laser Photobiomodulation of Wound Healing: A Review of Experimental Studies in Mouse and Rat Animal Models

Fischer-344 rats were exposed to quartz dusts and to quartz-bearing oil shale dusts in long-term inhalation studies. Aerosol concentrations of 12 mg/m/sup 3/ and 152-176 mg/m/sup 3/ for quartz and shale dusts, respectively, were used in exposure regimens lasting up to two years. Pulmonary fibrosis was observed in most animals surviving beyond 400 days. Adenocarcinomas and epidermoid carcinomas of the lung were observed in animals from all exposure groups, including those exposed to quartz alone. The pulmonary tumors were a late effect, with the earliest lung tumor being observed after 651 days. 13 references, 10 figures, 4 tables.

1984-01-01

333

British Library Electronic Table of Contents (United Kingdom)

Abstract Objectives: This investigation reviewed experimental studies of laser irradiation of wound healing in mice and rats published from 2003 to August 2008, respectively, to assess putative stimulatory effects of this treatment. Background: Animal models, including rodents, attempt to reflect human wound healing and associated problems such as dehiscence, ischemia, ulceration, infection, and scarring. They have played a key role in furthering understanding of underlying mechanisms involved in impaired wound healing, and in testing new therapeutic strategies including laser irradiation. Method: Original research papers investigating effects of laser or monochromatic light therapy on wound healing in mice and rats and published from January 2003 to August 2008 were retrieved from library...

2010-01-01

334

Jatropha Toxicity—A Review

British Library Electronic Table of Contents (United Kingdom)

Jatropha is a nonedible oil seed plant belonging to Euphorbiaceae family. Global awareness of sustainable and alternative energy resources has propelled research on Jatropha oil as a feedstock for biodiesel production. During the past two decades, several cultivation projects were undertaken to produce Jatropha oil. In future, the increased cultivation of toxic Jatropha plants and utilization of its agro-industrial by-products may raise the frequency of contact with humans, animals, and other organisms. An attempt was thus made to present known information on toxicity of Jatropha plants. The toxicity of Jatropha plant extracts from fruit, seed, oil, roots, latex, bark, and leaf to a number of species, from microorganisms to higher animals, is well established. Broadly, these extracts posse...

2010-01-01

335

In vivo distribution and excretion studies and in vitro blood studies on the kinetics of lead-203 in beagle dogs

How Much Does the Midline Incision Add to Urethral Diameter After Tubularized Incised Plate Urethroplasty? An Experimental Animal Study

Studies on the kinetics of the distribution of lead-203 in body fluids have been carried out in vitro, and in animal studies using beagle dogs. In vitro, the distribution of carrier free lead-203 between plasma and cells of canine blood at 37"0C was measured after the addition of isotope. In animal studies, activity in plasma was measured for about 150 hours, and activity in blood cells, urine and feces measured for about 400 hours after exposure to lead-203. Linear compartmental models for distribution of the isotope are presented for both in vitro and in vivo experimental systems. The models contain compartments for both untransformed lead, for isotope added in saline or citric acid, and transformed lead, as obtained by lead-203 incubation in plasma.

336

British Library Electronic Table of Contents (United Kingdom)

PurposeWe objectively quantified the gain in urethral diameter and the effect of stenting after tubularized incised plate urethroplasty in a rabbit hypospadias model. Materials and MethodsWe created a hypospadias model in 12 New Zealand white male rabbits by excising the ventral urethra. A 3 cm tattoo line was made longitudinally in the dorsal urethral plate midline. Two weeks later a 2 cm relaxing incision was made in the middle part of the tattooed line. The stretched incision width between the tattooed edges was measured, followed by urethral plate tubularization. Six rabbits were stented and 6 were nonstented. Two weeks later the animals were sacrificed and the distance separating the tattoo was measured at the midpoint of the tattooed line. Transverse sections at this point were exami...

2011-01-01

337

Flow cytometric analysis of respiratory tract cells exposed to oil shale and silica particulates. [Hamsters

Experimental Models for the Study of Female and Male Sexual Function

Flow cytometric techniques were used to measure the cytological and biochemical damage to respiratory tract cells in animals exposed to particulates. Hamsters were exposed to raw and spent oil shale particulates and silica by intratracheal instillation. Exfoliated lung cells were obtained by sacrificing the animals and lavaging the respiratory tract posterior to the trachea with saline. Cell samples were fixed in ethanol and stained with mithramycin for fluorescence analysis of DNA content. DNA content distributions from hamsters exposed to spent oil shale and silica particulates showed atypical changes 28 to 35 days later. Cell counts and total numbers of macrophages, leukocytes, and epithelial cells in the lavage fluid also showed marked changes related to time after exposure.

1979-01-01

338

British Library Electronic Table of Contents (United Kingdom)

ABSTRACT Introduction. Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim. To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods. Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries. Main Outcome Measure. Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback. Results. Fundamental research in animal models has led to considerable understanding of the physiological mechanisms underlying desi...

2010-01-01

339

ENSO affects sex ratio progeny in captive Iberian red deer despite a steady feeding regime

British Library Electronic Table of Contents (United Kingdom)

Climate variability greatly affects animals through direct and indirect effects. Animals with slow reproductive adaptation to ecological changes such as large mammals are likely to have evolved mechanisms to anticipate early such impacts of climate variability on the environment. One of the adaptive mechanisms between reproductive costs and benefits in mammals affects parental investment through biases in sex ratio. Deer might be likely to show an early detection of climate variability because conception takes place in early autumn, but the main raising cost in deer concerns lactation, which takes place at the end of the following spring. The aim of this paper is to assess whether there is a relationship between global indices of climate variability such as El Ni?o-Southern Oscillation (EN...

2011-01-01

340

Dendrosomes as novel gene porters-III

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND: It was previously reported that dendrosomes, i.e. neutral, biodegradable, covalent or self-assembled, hyperbranched, spheroidal nano-particles with a size ranging from 15 to 100 nm, provide a convenient and efficient means of gene delivery into various kinds of cells such as human hepatoma and kidney cells as well as animal models.RESULTS: New studies via circular dichroism show that hydrophilic and amphipathic dendrosomes either do not affect the DNA structure or moderately transform it from B- to A-conformation. Gene delivery into human liver, kidney, and endothelial cells as well as other animal cells like Bowes, U-937, Raw, CCRF-CEM, MOLT-4, K562, Huh-7 and VERO reveal that the genes are efficiently expressed and in comparison with other gene porters like Lipofectin or bact...

2008-01-01

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341

Chronic maternal stress affects growth, behaviour and hypothalamo?pituitary?adrenal function in juvenile offspring

British Library Electronic Table of Contents (United Kingdom)

Maternal stress during pregnancy, particularly that combined with low socioeconomic status (SES), has been linked to an increased risk for impaired behavioural and emotional development and affective disorders in children. In animal models, acute periods of prenatal stress have profound effects on hypothalamo-pituitary-adrenal (HPA) function and behaviour. However, few studies have determined the impact of chronic exposure to stress in animal models. The objective of this study was to determine the effects of chronic maternal stress (CMS) during the 2nd half of pregnancy and nursing on growth, locomotor behaviour and HPA axis function in juvenile guinea pig offspring. Pregnant guinea pigs were exposed to a random combination of variable stressors every other day over the 2nd half of gestat...

2008-01-01

342

Capsaicin-induced avoidance behavior in the terrestrial Gastropoda Megalobulimus abbreviatus: Evidence for TRPV-1 signaling and opioid modulation in response to chemical noxious stimuli

British Library Electronic Table of Contents (United Kingdom)

The aim of this study was to measure the nociceptive response (avoidance latency) of the land snail Megalobulimus abbreviatus (N=8 in each group) after topical capsaicin exposure (0.1% and 0.5% in 20% ethanol) and to compare it to a well-studied stressful (50??C) thermal stimulus model. We also tested if ruthenium red, and capsazepine, respectively nonselective and selective TRPV1 receptor antagonists, could modify both capsaicin- and thermal-evoked responses. Finally, animals were pretreated with morphine, naloxone or morphine plus naloxone prior to capsaicin stimuli. Latencies were measured when the animal lifted its head?foot complex 1?cm from the substrate. Data were compared using ANOVA and LSD post hoc, and the Student T Test (pM. abbreviatus.

2007-01-01

343

Assessment of the supramolecular structures presents into biological samples by SAXS technique;Avaliacao das estrutras supramoleculares presentes em amostras biologicas atraves da tecnica de SAXS

Application of radiolead to metabolic studies

In this work was made an assessment of the supramolecular structures presents into human breast tissue normal and pathological samples, as well as into two types of animals samples (tendon chicken and pork fat) using the small angle x-ray scattering (SAXS) technique. The scattering profiles of the samples were determined at the momentum transfer range O.150nm{sup -1}<=5:q(=4pi.sin({theta}/2)/{lambda})<=8.500nm{sup -1}. In this range, it was possible identify structures corresponding to collagen fibrils (glandular tissue) and to triacylglycerides (adipose tissue) from the correlation between the information extracted from the human breast tissues scattering profiles and those extracted from animals samples. (author)

2009-07-01

344

Results of the Interlaboratory Exercise CSN/CIEMAT-100 Among Environmental Radioactivity Laboratories (Soil); Resultados del Ejercicio Interlaboratorios de Radiactividad Ambiental CSN/CIEMAT-00 (Suelo)

A review is presented of the literature through 1977 on the uses of radioactive lead isotopes in metabolic studies in man, animals, and plants. These studies have been done mainly with the naturally-occurring, long-lived (22-yr half life) "2"1"0Pb, but a few were with 53-hr "2"0"3Pb or 10.6-hr "2"1"2Pb. Such studies have made possible estimates of the metabolic parameters of lead in man and animals, such as intestinal absorption, the ratio of fecal-to-urinary excretion of endogenous lead, residence time of lead in the body and in various organs, and the distribution in the body (skeleton, liver, kidney, and blood). Subsequently, these parameters and data have been used to trace the sources of lead for man, such as those from the atmosphere, food, cigarette smoke, and automobile exhaust.

345

Year 2000 assessment report, Los Alamos National Laboratory

The document describes the outcome of the CSN/CIEMAT-00 interlaboratory test comparison among environmental radioactivity laboratories. the exercise was organised according to the ISO-43 and the ISO/IUPAC/AOAC Harmonized Protocol for the proficiency testing of analytical laboratories. the test sample was a soil containing environmental levels of K-40, Ra-226, Ac-228, Sr-90, Cs-137, Cs-134, Pu (239-240) y Am-241. the Universidad Autonoma de Barcelona prepared the material and reported adequate statistical studies of homogeneity. The results of the exercise were computed for 30 participating laboratories, and their analytical performance was assessed using the u-score approach. A raised percentage of satisfactory laboratory performance has been obtained for all the analysis, being the best performance in gamma measurements. The exercise has drawn that several laboratories have ...

2002-07-01

346

p16^INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms

The purpose of this report is to advise managers on the status of Year 2000 readiness at the Laboratory and provide a summary of critical issues to be addressed in order to ensure that the Year 2000 date rollover will not disrupt Laboratory Operations. The Laboratory`s Year 2000 council members are in the first phase of Year 2000 plans: gathering data and assessing the status of their divisions or programs. This first snapshot of the Laboratory Year 2000 readiness assessment is expected to grow and change over time as more refined assessments, plans, and schedules are developed and as more information becomes available. Here are findings to date: (1) Embedded systems` status not known. (2) Preliminary cost estimates for Year 2000 repairs, testing, and implementation are estimated to be at least $5.9 million, not including embedded systems. (3) The Laboratory is required to make ...

1998-04-21

347

c-JUN N-TERMINAL KINASE MODULATES OXIDANT STRESS AND PEROXYNITRITE FORMATION INDEPENDENT OF INDUCIBLE NITRIC OXIDE SYNTHASE IN ACETAMINOPHEN HEPATOTOXICITY

Although caloric restriction (CR) has been shown to increase lifespan in various animal models, the mechanisms underlying this phenomenon have not yet been revealed. We developed an in vitro...Full Text Available

348

Tissue tropism and neuroinvasion of West Nile virus do not differ for two mouse strains with different survival rates

Acetaminophen (APAP) overdose, which causes liver injury in animals and humans, activates c-jun N-terminal kinase (JNK). Although it was shown that the JNK inhibitor SP600125 effectively reduced...Full Text Available

2010-07-01

349

The potential of non-toxic tannins to improve the utilisation of nitrogen compounds in grass silage by ruminants

West Nile virus (WNV) is a mosquito-borne flavivirus that infects the central nervous system of humans and other animals. In this study, we found that C3H/HeN (C3H) mice exhibited a higher morbidity...Full Text Available

2007-11-25

350

The influence of melatonin on metabolic changes in female rats induced by continuous irradiation and/or administration of 7,12-dimethylbenz/a/anthracene

DescriptionInefficient utilisation of dietary nitrogen (N) by animals results in the excretion of N in varying forms, with adverse environmental consequences. Grass silage is a major component of the diet of ruminant livestock in the UK, but the protein in silage is very highly degraded as a result of the ensilage process. This results in poor capture of the silage N by rumen microbes leading to overall poor utilisation for the synthesis of milk or meat. As a result, significant quantities of dietary N are [continued...

2006-01-31

351

The characteristics of a hydroxyapatite-chitosan-PMMA bone cement.

Metabolic profile is an important biological marker of neoplastic processes not only in the tumor itself but also in the host organism. The neuro-hormone melatonin has been implicated in the experiments as an oncostatic agent. Female Wistar:Han SPF rats (Velaz, Prague, Czech Republic) were irradiated continuously for 15 days using a daily gamma rays dose of 96 mGy. At the end of exposure one group of rats was administered 5 mg/kg b.w. of dimethylbenz/a/anthracene (DMBA) intragastrically. During the period of exposure to ionizing radiation a part of the animals was supplied with melatonin (M) at a concentration of 20 #mu#l/ml in drinking water. Selected parameters of lipid and carbohydrate metabolism and levels of selected hormones were determined 2, 30 and 100 days post-irradiation. The irradiation itself caused only small changes in tissue lipids. The application of a single low dose (subthreshold from the point of view of induction of mammary tumors) of DMBA ...

352

Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH

In this study, we propose a new bioactive bone cement (BBC), composed of natural bone powder (hydroxyapatite; HA), chitosan powder, and the currently available polymethylmethacrylate (PMMA) bone cement, for use in orthopedic surgeries such as vertebroplasty or as bone filler. Three types of BBCs (BBC I, BBC II, and BBC III) were prepared with different composition ratios. In vitro tests and animal studies were performed with the new BBCs, and with a currently available commercial PMMA bone cement. Surface morphology, chemical composition, changes in pH over time, exothermic temperatures, intrusion, and cellular responses were investigated in vitro. Scanning electron microscopy (SEM) and radiological and histological examinations were performed in animal studies. The results showed that the major components of the BBCs were C, O, Ca, P, Cl, Si, S, Ba, and Mg. The pH values of the BBCs decreased after 1 day, but eventually recovered to 7.2-7.4. ...

2004-11-01

353

Primary organization of nucleosomal core particles is invariable in repressed and active nuclei from animal, plant and yeast cells.

Increased oxidative stress is a known cause of cardiac dysfunction in animals and patients with diabetes, but the sources of reactive oxygen species [e.g., superoxide anion (O₂⁻)]...Full Text Available

2009-07-01

354

A refined map for the linear arrangement of histones along DNA in nucleosomal core particles has been determined by DNA-protein crosslinking. On one strand of 145-bp core DNA, histones are aligned in...Full Text Available

1985-05-24

355

NAME=\\

Methane fermentation of agricultural wastes and domestic animal's wastes

... All rickettsial diseases respond to treatment with antibiotics such as doxycycline and tetracycline As of 10 May, the Government of South Africa has reported 186 confirmed cases of RVF in humans, including 18 deaths, in Free State Province, Eastern Cape Province, Northern Cape Province, Western Cape, and North West Province. RVF is a viral disease that primarily affects animals (such as cattle, buffalo, sheep, goats and camels). The disease can also affect humans. The main mode of transmission of RVF ...

356

Mechanism for the anti-thyroid action of minocycline

Cattle and pig wastes, orange peels, compost, and grain husks were hydrolyzed in an alkaline medium to investigate the CH4 generation capacity. The respective CH4 production capacities from pig wastes and rice hulls were approximately 1 and approximately 0.1 L/g. The CH4 produced can be used to supplement energy requirements of farms.

1981-01-01

357

Measurement and apportionment of radon source terms for modeling indoor environments

Administration of minocycline (MN), a tetracycline antibiotic, produces a black pigment in the thyroids of humans and several species of experimental animals and antithyroid effects in rodents. We have previously shown that these effects appear to be related to interactions of MN with thyroid peroxidase (TPO), the key enzyme in thyroid hormone synthesis. In the present study, the mechanisms for inhibition of TPO-catalyzed iodination and coupling reactions by MN were investigated. 37 refs., 7 figs., 3 tabs.

1997-01-01

358

Late effects of "2"3"9Pu administered at representative stages of gestation

This research has two main goals; (1) to quantify mechanisms for radon entry into homes of different types and to determine the fraction of indoor radon attributable to each source and (2) to model and calculate the dose (and therefore alpha particle fluence) to cells in the human and animal tracheobronchial tree that is pertinent to induction of bronchogenic carcinoma from inhaled radon daughters.

1990-01-01

359

Kinetics of lead retention and distribution in suckling and adult rats

The protocol for a systematic comprehensive study of the influence of prenatal exposure on the tumorigenic and other adverse effects of "2"3"9Pu is described. The study has been initiated, all animals have been weaned, and postnatal function is being evaluated, although results are not yet available.

1977-05-01

360

Keeping chickens: a beginner's guide : Directgov - Environment and greener living

The kinetics of lead distribution was studied in suckling and adult rats 8 days after a single intraperitoneal injection of "2"0"3Pb. Marked differences were observed in the kinetics of lead retention and distribution in suckling as compared to adult rats. The rate of "2"0"3Pb disappearance was lower in the whole body, blood and kidneys, but higher in the liver, while the deposition processes predominated in the brain, femur and teeth of sucklings as compared to adult animals. (auth).

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361

Instrument of millimetre wave radiation and its effect on malignant tumor in mice and its application in clinic

...Keeping chickens: a beginner's guide : Directgov - Environment and greener living chickens, feeding chickens, egg marking, registering a ...flock, battery hens Chickens; Department for Environment, Food and Rural Affairs; Registrations; Animals; Livestock; Local government; Local ...authorities A guide for people keeping chickens on the laws for registering and feeding them, and how to spot key diseases. A ...guide for people keeping chickens on the laws for registering and feeding them, and how to spot key diseases. Keeping chickens: ...

362

In vivo distribution and excretion studies and in vitro blood studies on the kinetics of lead-203 in beagle dogs. [Thesis

An animated test is made for mice with malignant tumors irradiated by a self-made millimetre wave radiator for medical purpose. It is observed that S-180 sarcomas in mice after irradiation has been distinctly suppressed. And remarkable effects are shown through a lot of clinical practices on peptic ulcer, skin-deep ulcer, acute and chromic soft tissue injuries etc.

1995-12-31

363

Identification of a nuclear-localized nuclease from wheat cells undergoing programmed cell death that is able to trigger DNA fragmentation and apoptotic morphology on nuclei from human cells

The distribution of carrier free lead-203 between plasma and cells of canine blood in vitro was measured. Activity in the plasma decreased to less than 5% of the initial blood activity during the first 15 min and then exponentially with a half time of 160 min. Incubation in cell free plasma before addition to whole blood transformed the isotope, decreasing the amount subsequently associated with cells. In animal studies, activity was measured in plasma, blood cells, urine, and feces after exposure to lead-203. In one group, the animals were exposed by intravenous injection of dilute citric acid solutions of isotope. In a second group, carrier free isotope which had been transformed by incubation in plasma was injected intravenously. The kinetics of the distribution of the isotope differed between the two experimental groups. After injection of the transformed lead, the lead-203 content of the blood cell fraction rose from 10% of the dose at 5 ...

1980-01-01

364

Hygiene in air pipes. Tasks and requirements on clean air devices; Hygiene in Luftleitungen. Aufgaben und Anforderungen an RLT-Anlagen

PCD (programmed cell death) in plants presents important morphological and biochemical differences compared with apoptosis in animal cells. This raises the question of whether PCD arose independently...Full Text Available

2006-08-01

365

Genetic and somatic effects in animals maintained on tritiated water

Space HVAC systems are to provide hygienical room air. Air change is necessary because of pollutants released from materials or production processes but also because of the presence of humans or animals who consume oxygen. Poor room climate and/or poor air hygiene do not only reduce the felt comfort but may also result in a loss or profitability and higher sickness rates. (orig.)

2006-07-01

366

Effects of graded oral doses of a new 5-hydroxytryptamine/noradrenaline uptake inhibitor (Ro 15-8081) in comparison with 60 mg codeine and placebo on experimentally induced pain and side effect profile in healthy men.

The possible genetic (dominant lethal mutations (DLM) and cytogenetic changes in the regenerating liver) and somatic (hematopoietic stem cell changes, growth and nonspecific life time shortening) effects in mice maintained on tritiated water (HTO) over two generations was investigated. Results to date are summarized. (ACR)

1981-01-01

367

Effect of lifetime nutrition on ruminant carcass and meat quality

1. Ro 15-8081 (Hoffmann-La Roche, Basle, Switzerland) is a novel mixed 5-HT/noradrenaline uptake inhibitor producing potent antinociceptive effects in animal pain models. 2. In healthy man, two models...Full Text Available

1987-11-01

368

Determination of the Sr/Ca ratio in bones by XRFA

DescriptionThis application is a request for Bridge Link funds to support studies in order to develop a full proposal under the Link Sustainable Livestock Scheme in collaboration with Dr Nigel Scollan of IGER. The hypothesis being examined is that the poor performance of some ruminants is due to poor nutrition at strategic time points during the animal's development. The initial hypothesis will be tested in sheep and the results from this will be used to develop the full proposal. Excessive fat in ruminan [continued...

2006-01-31

369

Cordycepin Blocks Lung Injury-Associated Inflammation and Promotes BRCA1-Deficient Breast Cancer Cell Killing by Effectively Inhibiting PARP

Radionuclide X-ray fluorescence analysis was used for the determination of Sr/Ca ratio in bones to test the influence of a diet on this ratio. Significant differences were observed for Sr/Ca ratio in bones of various animals. Only small differences in the Ca/Sr ratio were observed for the samples of various prehistoric human bones. (author) 4 refs.; 4 tabs.

1989-11-01

370

Comparison of a multivalent viral vaccine program versus a univalent viral vaccine program on animal health, feedlot performance, and carcass characteristics of feedlot calves

Cordycepin has been shown to interfere with a myriad of molecular processes from RNA elongation to kinase activity, and prevents numerous inflammatory processes in animal models. Here we show in a mouse...Full Text Available

2011-09-01

371

Behavioral response of rats exposed to high-power microwave radiation. Interim report, September 1986-January 1987

A field study was conducted under commercial feedlot conditions at 2 sites in western Canada to determine the relative effects of a univalent viral vaccine (MLV 1) program versus a multivalent viral...Full Text Available

2003-01-01

372

Behavioral Stress May Increase the Rewarding Valence of Cocaine-Associated Cues Through a Dynorphin/?-Opioid Receptor-Mediated Mechanism without Affecting Associative Learning or Memory Retrieval Mechanisms

Emerging high-power microwave technologies require that bioeffects of exposure to this type of radiation be investigated for health and safety considerations. Disruption of animal behavior is reported to be a sensitive indicator of microwave exposure. Three behavioral tasks were chosen for this initial investigation of exposure to U.S. Air Force high-power microwave emitters. The tasks were: (1) single-trail avoidance, (2) water satiation, and (3) rotarod performance. Exposure to high-power microwave radiation from the USAFSAM peak-power simulator significantly affected the single-trail avoidance task. Neither the single-trail avoidance task nor rotarod performance was affected by the Gypsy emitter. However, animals exposed to 9-kW and 11-kW outputs from the USAFSAM emitter spent significantly less time imbibing water postexposure than sham-exposed animals. The most consistent finding in the animals ...

1988-02-01

373

Apoptosis induced by high- and low-LET radiations

Stress exposure increases the risk of addictive drug use in human and animal models of drug addiction by mechanisms that are not completely understood. Mice subjected to repeated forced swim stress...Full Text Available

2010-08-01

374

Animal manure digestion systems in central Europe

Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals. (orig.).

375

Anesthetics and electroconvulsive therapy seizure duration: implications for therapy from a rat model.

This work provides an overview of existing plants in Europe and describes the substrates being used. It focuses on the individual farm-scale and community plants, as these are the two main types now being built. It also describes plants currently under construction, especially in Germany and Denmark, where the major efforts are focused. A description of how the technique has developed over the past few years, its current state of development, the motivation and economic balance, and the substrate characteristics, is presented.

1996-01-01

376

??⁺ T-Lymphocyte Cytotoxicity against Envelope-Expressing Target Cells Is Unique to the Alymphocytic State of Bovine Leukemia Virus Infection in the Natural Host

The anesthetic agents methohexital (Brevital), Innovar, and ketamine (Ketaject) were examined for their effect on seizure duration following electroconvulsive stimulation in a rat model of electroconvulsive therapy (ECT). Compared to unanesthetized control animals, methohexital anesthesia shortened seizure duration by 42%, ketamine anesthesia tended to increase seizure duration, and Innovar anesthesia had no effect on duration of seizures. PMID:7349626

1981-12-01

377

[Single and 4-week oral toxicity studies of prulifloxacin (NM441) in aged dogs].

Bovine leukemia virus (BLV) is a complex B-lymphotrophic retrovirus of cattle and the causative agent of enzootic bovine leukosis. Serum antibody in infected animals does not correlate with protection...Full Text Available

2000-09-01

378

Matrix diffusion studies by electrical conductivity methods. Comparison between laboratory and in-situ measurements

Single-dose and repeated dose toxicity studies of prulifloxacin, a new antibacterial agent, were conducted in aged beagle dogs. I. A single-dose toxicity study Prulifloxacin was administered orally to aged female dogs at a single dose of 2500 and 5000 mg/kg. No death occurred in any group. Vomiting was observed in one of two animals at 2500 mg/kg and in both animals at 5000 mg/kg 3-4 hr after dosing. At 5000 mg/kg, vomiting was observed in both animals after feeding on the day after dosing. One animal also showed soft stool. Thereafter, no abnormalities were observed in any animal. No test article related changes were noted in food consumption, water consumption, body weight or pathological examination in any group. The results show that the lethal dose of prulifloxacin is judged to be greater than 5000 mg/kg in aged female dogs. II. A repeated dose toxicity study Aged male and ...

1996-06-01

379

The crystalline-silicon photovoltaic R&D project at NREL and SNL

Traditional laboratory diffusion experiments in rock material are time consuming, and quite small samples are generally used. Electrical conductivity measurements, on the other hand, provide a fast means for examining transport properties in rock and allow measurements on larger samples as well. Laboratory measurements using electrical conductivity give results that compare well to those from traditional diffusion experiments. The measurement of the electrical resistivity in the rock surrounding a borehole is a standard method for the detection of water conducting fractures. If these data could be correlated to matrix diffusion properties, in-situ diffusion data from large areas could be obtained. This would be valuable because it would make it possible to obtain data very early in future investigations of potentially suitable sites for a repository. This study compares laboratory electrical conductivity measurements with ...

1998-09-01

380

Optimization of an interlaboratory program for the certification of a multi-element plagiogneiss reference material

This paper summarizes the U.S. Department of Energy R&D program in crystalline-silicon photovoltaic technology, which is jointly managed by Sandia National Laboratories and National Renewable Energy Laboratory. This program features a balance of basic an d applied R&D, and of university, industry, and national laboratory R&D. The goal of the crystalline-silicon R&D program is to accelerate the commercial growth of crystalline-silicon photovoltaic technology, and four strategic objectives were identified to address this program goal. Technical progress towards meeting these objectives is reviewed.

1996-12-31

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

Mini-conference on Angular Momentum Transport in Laboratory and Nature

A sample of garnet-biotite plagiogneiss, GBPg-1 is currently being developed as a certified reference material at the Vinogradov Institute of Geochemistry. It was used as the sample that was distributed round 7 of International Proficiency Testing Program (GeoPT7) and was analyzed by 76 geoanalytical laboratories around the world. Twenty Russian laboratories involved in the interlaboratory experiment also analyzed GBPg-1. The resultant analytical data obtained from these two experiments has allowed GBPg-1 to be certified as a state standard sample for 50 elements. It also enabled a comparison of the quality of data developed by the Russian and international geoanalytical laboratories, to optimize the outcome of this interlaboratory experiment.

2003-02-03

382

Laboratory Directed Research and Development Annual Report - Fiscal Year 2000

This paper provides a concise summary of the current status of the research and future perspectives discussed in the Mini-Conference on Angular Momentum Transport in Laboratory and Nature. This Mini-conference, sponsored by the Topical Group on Plasma Astrophysics, was held as part of the American Physical Society's Division of Plasma Physics 2007 Annual Meeting (November 12{16, 2007). This Mini-conference covers a wide range of phenomena happening in fluids and plasmas, either in laboratory or in nature. The purpose of this paper is not to comprehensively review these phenomena, but to provide a starting point for interested readers to refer to related research in areas other than their own.

2008-05-06

383

Idaho National Laboratory 2013-2022 Ten-Year Site Plan

The projects described in this report represent the Laboratory's investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. In accordance with DOE guidelines, the report provides, a) a director's statement, b) an overview of the laboratory's LDRD program, including PNNL's management process and a self-assessment of the program, c) a five-year project funding table, and d) project summaries for each LDRD project.

2001-04-01

384

Environmental Measurements Laboratory fiscal year 1998: Accomplishments and technical activities

The Idaho National Laboratory (INL) Ten-Year Site Plan (TYSP) describes the strategy for accomplishing the long-term objective of transforming the laboratory to meet Department of Energy (DOE) national nuclear research and development (R&D) goals, as outlined in DOE strategic plans. The plan links R&D mission goals and INL core capabilities with infrastructure requirements (single- and multi-program), establishs the 10-year end-state vision for INL complexes, and identifies and prioritizes infrastructure needs and capability gaps. The TYSP serves as the basis for documenting and justifying infrastructure investments proposed as part of the FY 2013 budget formulation process.

2011-06-01

385

Energy and technology review

The Environmental Measurements Laboratory (EML) is government-owned, government-operated, and programmatically under the DOE Office of Environmental Management. The Laboratory is administered by the Chicago Operations Office. EML provides program management, technical assistance and data quality assurance for measurements of radiation and radioactivity relating to environmental restoration, global nuclear nonproliferation, and other priority issues for the Department of Energy, as well as for other government, national, and international organizations. This report presents the technical activities and accomplishments of EML for Fiscal Year 1998.

1999-01-01

386

Development of a solvent extraction process for cesium removal from SRS tank waste

The state of the laboratory address by LLNL Director Roger Batzel is summarized, and a breakdown of the laboratory funding is given. The Livermore defense-related committment is described, including the design and development of advanced nuclear weapons as well as research in inertial confinement fusion, nonnuclear ordnance, and particle beam technology. LLNL is also applying its scientific and engineering resources to the dual challenge of meeting future energy needs without degrading the quality of the biosphere. Some representative examples are given of the supporting groups vital for providing the specialized expertise and new technologies required by the laboratory's major research programs. (GHT)

1982-07-01

387

Argonne National Laboratory-East evolution of solid waste management

An alkaline-side solvent extraction process was developed for cesium removal from Savannah River Site (SRS) tank waste. The process was invented at Oak Ridge National Laboratory and developed and tested at Argonne National Laboratory using singlestage and multistage tests in a laboratory-scale centrifugal contactor. The dispersion number, hydraulic performance, stage efficiency, and general operability of the process flowsheet were determined. Based on these tests, further solvent development work was done. The final solvent formulation appears to be an excellent candidate for removing cesium from SRS tank waste.

2001-06-30

388

View Record - NASA Jet Propulsion Laboratory

The purpose of this report is to provide the reader with a basic understanding of Argonne National Laboratory`s current general refuse disposal and material recycling programs, how they were developed, and where they are going. In order to better understand the current situation, a brief description of the facilities past practices is explained. ANL is a multi-program research and development center owned by DOE and operated by the University of Chicago. Argonne`s primary facilities are on a 1,700 acre site, 27 miles southwest of Chicago. Fifty-seven major buildings house approximately 4,500 employees at the site.

1996-07-01

389

Thermal conductivity of polyisocyanurate foam board insulation blown with CFC-11 substitutes: Laboratory and long-term field measurements

Jan 13, 2011 ... This 360-degree mosaic of images from the navigation camera on ... The Radiation Assessment Detector, shown prior to its September 2010 ...

390

This paper reports on a series of laboratory and controlled test site measurements of the thermal conductivity of polyisocyanurate foam laminated boardstock roof insulations produced with several different blowing agents; CFC-11, HCFC-123, HCFC-14lb, and two blends of the HCFCs. The behavior of the experimental foams with HCFCs is compared to that of conventional polyisocyanurate foam blown with CFC-11. Thermal drift observed from two years of field exposure is compared to laboratory accelerated aging tests and the laboratory and field measurement techniques are described. This work is part of a Joint Industry/Government Project established in the United States to evaluate the technical viability of HCFC alternative blowing agents for polyisocyanurate foam roof insulations.

1992-01-01

391

The denturism initiative

The alpha-gamma lead cell system in the post-irradiation laboratory of Metallurgy Division, AERE, Harwell

Denturism, an organized movement by dental laboratory technicians to increase their control over the provision of denture services to the public, has generated a great deal of controversy among members...Full Text Available

1981-09-01

392

Tear Strength of Elastomers under Threshold Conditions

... alpha particles beta particles gamma radiation lead hot cells bricks shielding

393

Stability and disturbance of large dc superconducting magnets

... the Naval Research Laboratory (Contract NOOO14-82-K-2015), Cabot Corporation, and Lord Kinematics Division of Lord Corporation. The authors ...

1983-04-01

394

Space Images - NASA Jet Propulsion Laboratory

This paper addresses the stability aspects of several successful dc superconducting magnets such as large bubble chamber magnets, and magnets for the Mirror Fusion Test Facility and MHD Research Facility. Specifically, it will cover Argonne National Laboratory 12-Foot Bubble Chamber magnets, the 15-foot Bubble Chamber magnets at Fermi National Laboratory, the MFTF-B Magnet System at Lawrence Livermore National Laboratory, the U-25B Bypass MHD Magnet, and the CFFF Superconducting MHD magnet built by Argonne National Laboratory. All of these magnets are cooled in pool-boiling mode. Magnet design is briefly reviewed. Discussed in detail are the adopted stability critera, analyses of stability and disturbance, stability simulation, and the final results of magnet performance and the observed coil disturbances.

1981-11-11

395

Report of the Federal Panel on Formaldehyde.

Jan 18, 2011 ... The Radiation Assessment Detector, shown prior to its September 2010 ... This 360-degree panorama shows the vista from the location where ...

396

Quantitative investigation of the crowding effect of Hymenolepis diminuta in Rattus norvegicus

The Federal Panel on Formaldehyde concluded that definitive experiments exist which demonstrate the mutagenicity and carcinogenicity of formaldehyde under laboratory conditions. Formaldehyde induces...Full Text Available

1982-02-01

397

Publications of Los Alamos research 1988

This laboratory exercise demonstrates some basic principles in parasitology by using experimental studies of the relationship of Hymenolepis diminuta with its rodent host.

2000-01-01

398

Profiles - NASA Jet Propulsion Laboratory

This bibliography lists unclassified publications of work done at the Los Alamos National Laboratory for 1988. The entries, which are subdivided by broad subject categories, are cross-referenced with an author index and a numeric index.

1989-12-01

399

Physiological and Biochemical Variations during the Molt Cycle in Juvenile Litopenaeus vannamei under Laboratory ...

Jun 30, 2003 ... He graduated from training with top honors and served as a parachute rigger and paratrooper for the 82nd airborne division at Fort Bragg, ...

400

OAK RIDGE NATIONAL LABORATORY UNION CARBIDE CORPORATION NUCLEAR ...

... 05). In contrast with the information available for Penaeus monodon Fabricius, 1798 (Ferraris et al., 1987) and L. vannamei ( ... ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Nuclear waste plans enter critical phase

W. Wayne Scott, Chattanooga State Technical Institute, 4501 Amnico Highway,. Chattanooga, Tennessee 3401. Robert L. Seale, University of Arizona, Tuscon, ...

402

NSF-NIST Interaction in Chemistry, Materials Research, Molecular Biosciences, Bioengineering and Chemical Engineering

A brief article considers the possible result of the enquiry into Nirex`s plan to build an underground rock laboratory at Sellafield in relation to radioactive waste disposal in the UK. (UK).

1996-10-31

403

NASA SBIR/STTR Technologies

NSF-NIST Interaction in Chemistry, Materials Research, Molecular Biosciences, Bioengineering, and ... Laboratory (CSTL). Materials research is centralized in the Materials Science and Engineering ...

404

NASA Jet Propulsion Laboratory - Lecture series

(e.g. enclosed cooktop with built in emissions capture and treatment) . " Test hardware in laboratory, reduced pressure and analog habitat. " Objective 1. ...

405

NASA - Spitzer Sees Spider Web of Stars

A Self-Powered Underwater Robot for Ocean Exploration and Beyond ... first unmanned underwater vehicle (UUV) that is completely powered by renewable energy . ...

406

NASA - A Cosmic Inkblot Test

star formation. To either side of the center, a small bar of dust and gas is helping to fuel the new stars. NASA's Jet Propulsion Laboratory, Pasadena, Calif., manages the...

2011-07-20

407

Mechanism of Interaction of Radiowaves and Microwaves with ...

material may survive intact and mix back into interstellar gas clouds, helping to fuel the next generation of stars. NASA's Jet Propulsion Laboratory, Pasadena, Calif.,...

2011-08-10

408

Laboratory Description of Harbor Idealized Tests. Volume 1 ...

Page 1. USAFSAM-TR-89-1 AD-A221 893 ... Dr. Johnathan L. Kiel (USAFSAM/RZP) was the Laboratory Project Scientist-in-Charge. ...

1990-03-01

409

Interstellar PAH emission in the 11-14 micron region: new insights from laboratory data and a tracer of ionized PAHs

... modules 2 and 3, 45 ft from each end) in a ... The toe of the stone revetment was 2 ft out from the ... in parentheses are for the current meters in layout 2. ...

1993-03-01

410

Innovative Treatment and Remediation Demonstration Program Summary Report: Conceptual Model Review and Remediation Options for Los Alamos National Laboratory Technical Area 54, Material Disposal Area L

The Ames infrared spectral database of isolated, neutral and ionized polycyclic aromatic

1999-01-01

411

In vivo range of motion of the lumbar spinous processes

No abstract prepared.

2002-11-01

412

The study design included an in vivo laboratory study. The objective of the study is to quantify the kinematics of the lumbar spinous processes in asymptomatic patients during un-restricted functional...Full Text Available

2009-09-01

413

Guidance for Industry

... accidentally released from a Soviet military laboratory (Meselson ... Robert Koch and Louis Pasteur worked to introduce ... species (eg, rat, mouse, dog, monkey) for ...

414

GeoPowering the West

From laboratory curiosity to a symbol of hope. Methane hydrate, a new energy source?; Von einer Laborkuriositaet zum Hoffnungstraeger? Methanhydrat koennte die Energiereserven erhoehen

Summary brochure of GeoPowering the West (GPW) activities, and areas of technology transfer and market transformation. It also provides current contact information for key DOE and national laboratory staff representing the GPW program.

2007-02-01

415

Emissions Inventory Report Summary Reporting Requirements for the New Mexico Administrative Code, Title 20, Chapter 2, Part 73 (20 NMAC 2.73) for Calendar Year 1998

Short communication

1995-05-01

416

ESTABLISHMENT OF AN ENVIRONMENTAL CONTROL TECHNOLOGY LABORATORY WITH A CIRCULATING FLUIDIZED-BED COMBUSTION SYSTEM

Los Alamos National Laboratory (the Laboratory) is subject to emissions reporting requirements for regulated air contaminants under Title 20 of the New Mexico Administrative Code, Chapter 2, Part 73 (20 NMAC 2.73), Notice of Intent and Emissions Inventory Requirements. The Laboratory has the potential to emit 100 tons per year of suspended particulate matter, nitrogen oxides, carbon monoxide, sulfur oxides, and volatile organic compounds. For 1998, combustion products from the industrial sources contributed the greatest amount of criteria air pollutants from the Laboratory. Research and development activities contributed the greatest amount of volatile organic compounds. Emissions of beryllium and aluminum were reported for activities permitted under 20 NMAC 2.72 Construction Permits.

1999-09-01

417

Development of a robotics system for automated chemical analysis of sediment, sludges, and soils

This report is to present the progress made on the project ''Establishment of an Environmental Control Technology Laboratory (ECTL) with a Circulating Fluidized-Bed Combustion (CFBC) System'' during the period October 1, 2004 through December 31, 2004. The following tasks have been completed. First, the renovation of the new Combustion Laboratory and the construction of the Circulating Fluidized-Bed (CFB) Combustor Building have proceeded well. Second, the detailed design of supporting and hanging structures for the CFBC was completed. Third, the laboratory-scale simulated fluidized-bed facility was modified after completing a series of pretests. The two problems identified during the pretest were solved. Fourth, the carbonization of chicken waste and coal was investigated in a tube furnace and a Thermogravimetric Analyzer (TGA). The experimental results from this study are presented in ...

2005-01-30

418

Dependence of stress corrosion cracking behavior of SUS316L stainless steel introduced surface hardened layer on the test period in the high temperature water

The introduction of automation technology into the analytical laboratory holds the promise of higher efficiency, improved productivity, and lower costs. However, the conventional ''laboratory robot'' widely used today may not offer the work envelope or reliability required in a high workload laboratory performing quality control or environmental analytical services. To address this need, a demonstration workcell was assembled utilizing an industrial-class robotics system to automate a standard EPA acid digestion protocol. With further development of graphical user interfaces and error recovery software, the technology will significantly enhance the ability of laboratories to meet increasingly complex environmental demands. 7 refs., 2 figs., 1 tab.

1989-11-26

419

... Industry, Material Science Research Laboratory, Yokosuka, Kanagawa (Japan)

2010-10-01

420

Curvularia keratitis.

Course, Curriculum, and Laboratory Improvement (CCLI)

PURPOSE: To determine the risk factors and clinical signs of Curvularia keratitis and to evaluate the management and outcome of this corneal phaeohyphomycosis. METHODS: We reviewed clinical and laboratory...Full Text Available

2001-01-01

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421

Corrosion Brochure - KSC Corrosion Technology Laboratory Home - NASA

... teaching and learning; Creating learning materials and teaching strategies; Developing faculty ... achieve educational innovations. Educational Materials Development (EMD): A project under the former ...

422

CRC manual of nuclear medicine: Procedures. Fourth Edition

Specialized tests can be designed to study impingement-corrosion, erosion- corrosion, cathodic protection systems, cavitation and other velocity effects. ...

423

Benthic Habitats of the Asuncion Island Northern Mariana Archipelago 2001-2003, Derived From IKONOS Imagery

This book discusses the procedures applied for the clinical nuclear medicine laboratory. The procedures are presented as proven guidelines. The chapters are included on quality assurance, radionuclide handling, and radiation safety.

1983-01-01

424

Benthic Habitats of Swains Island 2001-2003, Derived from IKONOS Imagery

... Coastal Monitoring and Assessment, the University of Hawaii, BAE Systems Spectral Solutions and Analytical Laboratories of Hawaii, LLC. ... ...

425

Benthic Habitat of Oahu Derived From IKONOS and Quick Bird Satellite Imagery, 2004-2006

... Coastal Monitoring and Assessment, the University of Hawaii, BAE Systems Spectral Solutions and Analytical Laboratories of Hawaii, LLC. ... ...

426

Benefits of Using the Photosimulation Laboratory Environment ...

... Coastal Monitoring and Assessment, the University of Hawaii, BAE Systems Spectral Solutions and Analytical Laboratories of Hawaii, LLC. ... ...

427

Awards 1988-1991 Curriculum Development in Mathematics-- Calculus and the Bridge to Calculus

... with the ability to capture imagery in raw 24-bit format, combined with large memory storage devices enable high resolution imagery to be captured ...

2002-08-01

428

... curricula and prototypical instructional materials have been emphasized. The program has provided ... materials are adapted and implemented on a state-wide basis. The laboratory materials and the text ...

429

Attendees - MEPAG - NASA

An Advance in Superconducting Magnet Technology Opens the Door...

Barlow, Nadine Northern Arizona University, Flagstaff, AZ. 10. Barker, Don NASA Johnson Space Center, TX. 11. Beaty, David NASA Jet Propulsion Laboratory, ...

430

Airbags to Martian Landers: Analyses at Sandia National Laboratories

magnet research at several national laboratories through its Advanced Accelerator Technology Program. The HEP Conductor Development Program, a collaboration among national...

2011-08-20

431

Ada Compiler Validation Summary Report: Certificate Number ...

A new direction for the national laboratories is to assist US business with research and development, primarily through cooperative research and development agreements (CRADAs). Technology transfer to the private sector has been very successful as over 200 CRADAs are in place at Sandia. Because of these cooperative efforts, technology has evolved into some new areas not commonly associated with the former mission of the national laboratories. An example of this is the analysis of fabric structures. Explicit analyses and expertise in constructing parachutes led to the development of a next generation automobile airbag; which led to the construction, testing, and analysis of the Jet Propulsion Laboratory Mars Environmental Survey Lander; and finally led to the development of CAD based custom garment designs using 3D scanned images of the human body. The structural analysis of these fabric structures is described as well as a ...

1994-03-01

432

Acquired extrahepatic portosystemic shunts in a young dog

... Standards Validation Group National Computer Systems Laboratory National Institute of Standards and Technology ... STANDARD. ... (See test Ci )i3A. ...

1989-08-18

433

Accelerator technology program, January-June 1982. Status report

AbstractA young, male miniature poodle was presented with severe neurological problems. Laboratory tests and ultrasonograph examination were consistent with extrahepatic portosystemic...Full Text Available

2006-07-01

434

A mobile remote sensing laboratory for water vapor, trace gas, aerosol, and wind speed measurements

The major projects of the Los Alamos National Laboratory's Accelerator Technology Division are discussed, covering activities that occurred during the first six months of calendar 1982.

435

A Critical Reassessment of the Role of Mitochondria in Tumorigenesis

The Lawrence Livermore National Laboratory has developed a mobile field laboratory for remote measurement of atmospheric processes and observables that are important in global climate change, dispersal of hazardous materials, and atmospheric pollution. Specific observables of interest are water vapor, trace gases, aerosol size and density, wind, and temperature. The goal is to study atmospheric processes continuously for extended periods in remote field locations. This laboratory has just reached field ready status with sensors for aerosol and trace gas measurement based on established techniques. A development program is underway to enhance the sensor suite with several new techniques and instruments that are expected to significantly extend the state of the art in remote trace gas analysis. The new sensors will be incorporated into the lab during the next two years.

1993-03-19

436

A - Z Index : Environmental Energy Technologies Division

BackgroundMitochondrial DNA (mtDNA) is being analyzed by an increasing number of laboratories in order to investigate its potential role as an active marker of tumorigenesis...Full Text Available

2005-11-01

437

@ work' video segment features Robotic Software Engineer

Buildings Energy-Efficient Research Laboratories Energy Efficiency in Federal Facilities Energy Efficiency Standards Group Energy Efficient Windows Collaborative Energy &...

2011-07-15

438

ScienceCinema

@ work highlights Idaho National Laboratory employees and the jobs they perform.This segment features Robotic Software Engineer Miles Walton.

439

2004 Office of Fossil Energy Fuel Cell Program Annual Report

+ September 2006 - NASA Jet Propulsion Laboratory

Annual report of fuel cell projects sponsored by Department of Energy, National Energy Technology Laboratory.

2004-11-01

440

Waste monitoring system for effluents

Post-drive imaging included 360-degree view by the navigation camera and .... Sol 938: Opportunity completed another assessment of the clarity of the sky. ...

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441

Waste minimization and pollution prevention in D&D operations at the Argonne National Laboratory-East site

The waste monitoring system in use at Los Alamos National Laboratory`s Plutonium Facility, TA-55, is a computer-based system that proves real-time information on industrial effluents. Remote computers monitor discharge events and data moves from one system to another via a local area network. This report describes the history, system design, summary, instrumentation list, displays, trending screens, and layout of the waste monitoring system.

1995-07-01

442

Status report of the 17-M VAWT program

Argonne National Laboratory (ANL) is implementing waste minimization and pollution prevention activities into its conduct of decontamination and decommissioning (D&D) projects. Many of these activities are rather straight forward and simple approaches, yet they are often overlooked and not implemented as often as they should or could be. Specific activities involving recycling and reuse of materials and structures, which have proven useful in lowering decommissioning and disposal costs on D&D projects at ANL are presented.

1996-07-01

443

Replacement of the Idaho National Engineering Laboratory Health Physics Instrumentation Laboratory

This report is directed at the commercial potential of the 17-m, 100 kW Darrieus Vertical Axis Wind Turbine (VAWT) developed under DOE funding by Sandia National laboratories (SNL) and Alcoa Laboratories. Three of the turbines have come on line over the past 14 months and long-term testing is in progress. As the first commercially adapted Darrieus turbines built by DOE, the superior cost, structural integrity, and output characteristics demonstrated by the prototypes appear particularly promising.

1981-01-01

444

Real time operating system for a nuclear power plant computer

The DOE-Idaho Operations Office (DOE-ID) has prepared an environmental assessment (EA) on the replacement of the Idaho National Engineering Laboratory Health Physics Instrumentation Laboratory at the Idaho National Engineering Laboratory (INEL). The purpose of this project is to replace the existing Health Physics Instrumentation Laboratory (HPIL) with a new facility to provide a safe environment for maintaining and calibrating radiation detection instruments used at the Idaho National Engineering Laboratory. The existing HPIL facility provides portable health physics monitoring instrumentation and direct reading dosimetry procurement, maintenance and calibration of radiation detection instruments, and research and development support-services to the INEL and others. However, the existing facility was not originally designed for laboratory activities and does ...

1995-05-01

445

Radioactive and mixed waste management plan for the Lawrence Berkeley Laboratory Hazardous Waste Handling Facility

A quadruply redundant synchronous fault tolerant processor (FTP) is now under fabrication at the C.S. Draper Laboratory to be used initially as a trip monitor for the Experimental Breeder Reactor EBR-II operated by the Argonne National Laboratory in Idaho Falls, Idaho. The real time operating system for this processor is described.

1986-09-01

446

Quality assurance on the Idaho National Engineering Laboratory Buried Waste Program

This Radioactive and Mixed Waste Management Plan for the Hazardous Waste Handling Facility at Lawrence Berkeley Laboratory is written to meet the requirements for an annual report of radioactive and mixed waste management activities outlined in DOE Order 5820.2A. Radioactive and mixed waste management activities during FY 1994 listed here include principal regulatory and environmental issues and the degree to which planned activities were accomplished.

1995-01-01

447

Qualitative risk evaluation of environmental restoration programs at Brookhaven National Laboratory

This paper discusses the clean-up of an Idaho National Engineering Laboratory (INEL) site utilized for disposal of transuranic contaminated waste from 1954 until 1970. The author presents requirements of the environmental protection statutes that have generated quality assurance requirements in addition to those historically implemented as a part of facility design, construction and operation. A hierarchy of program guidance quality documentation and procedures is discussed. Data qualification and computer database management are identified as requirements.

1989-04-02

448

National Renewable Energy Laboratory 2005 Research Review

This report documents the evaluation of risks associated with environmental restoration activities at Brookhaven National Laboratory using two tools supplied by DOE to provide a consistent set of risk estimates across the DOE complex: Risk Data Sheets (RDS) and Relative Risk Ranking. The tools are described, the process taken characterized, results provided and discussed. The two approaches are compared and recommendations provided for continuing improvement of the process.

1996-05-01

449

Idaho National Engineering Laboratory Nonradiological Waste Management Information for 1992 and record to date

Science and technology are at the heart of everything we do at the National Renewable Energy Laboratory, as we pursue innovative, robust, and sustainable ways to produce energy--and as we seek to understand and illuminate the physics, chemistry, biology, and engineering behind alternative energy technologies. This year's Research Review highlights the Lab's work in the areas of alternatives fuels and vehicles, high-performing commercial buildings, and high-efficiency inverted, semi-mismatched solar cells.

2006-06-01

450

Epidemiological and clinical features of 1,149 persons with Lyme disease identified by laboratory-based surveillance in Connecticut.

This document provides detailed data and graphics on airborne and liquid effluent releases, fuel oil and coal consumption, water usage, and hazardous and mixed waste generated for calendar year 1992. This report summarizes industrial waste data records compiled since 1971 for the Idaho National Engineering Laboratory (INEL). The data presented are from the INEL Nonradiological Waste Management Information System.

1993-08-01

451

An evaluation of the utility of routine laboratory monitoring of juvenile idiopathic arthritis (JIA) patients using non-steroidal anti-inflammatory drugs (NSAIDs): a retrospective review

Laboratory-based surveillance of Lyme disease in Connecticut during 1984 and 1985 identified 3,098 persons with suspected Lyme disease; 1,149 were defined as cases. Lyme disease incidence in Connecticut...Full Text Available

1989-05-01

452

Laboratory for characterization of spent nuclear fuel and high/medium level radioactive waste. Experimental results and performances

BackgroundNo consensus evidence-based guidelines for the routine laboratory monitoring of children with JIA receiving non-steroidal anti-inflammatory drugs (NSAIDs) exist. The purpose...Full Text Available

453

Intercomparison of soil radon concentration measurements

During the phases of separation, treatment, conditioning and storage of radioactive waste, destructive and nondestructive methods for their characterization are needed. In order to satisfy this necessity, in the frame of the National Program of Research and Development, the 'Laboratory for characterization of spent nuclear fuel and high/medium level radioactive waste- LABORAD' was created. The purpose of the project was to accredit the analysis methods available in the laboratory, and also to develop new methods for the characterization of the radioactive waste. A special attention was paid to the high-level radioactive waste and spent nuclear fuel characterization that require special facilities for handling. These facilities (e.g. hot cells, remote handlers, transport container) are already available in our institute. Experimental results and performances obtained during validation of the methods are presented in this paper. The ...

2009-05-27

454

Effects of a chelating resin on metal bioavailability and toxicity to estuarine invertebrates: Divergent results of field and laboratory tests

In October last year the first intercomparison of measurements of the soil radon concentrations between various laboratories in Slovakia was realised. The organisation of this intercomparison was conducted by the Slovak Legal Metrology in Banska Bystrica together with the Slovak National Accreditation Service in Bratislava (SNAS). The scientific guarantee of the exercise was the State metrological Centre for radon quantities, which is working at the Research base of Slovak Medical University in Bratislava. The main objective of the intercomparison was to verify the correctness of the methods for the soil radon measurements of the authorised laboratories for radon volume activities in soil air. The intercomparison (signed as SLM ILC 3/03) was performed as a 'circular' metrology comparison, in accordance with a methodical directive MSA 0117-98, published by SNAS. Six laboratories were participating on the intercomparison and ...

2004-11-01

455

Thermal responses to 5. 6-GHz radiofrequency radiation in anesthetized rats. Effect of chlorpromazine

Benthic invertebrates can uptake metals through diffusion of free ion solutes, or ingestion of sediment-bound forms. This study investigated the efficacy of the metal chelating resin SIR 300TM in adsorbing porewater metals and isolating pathways of metal exposure. A field experiment (Botany Bay, Sydney, Australia) and a laboratory toxicity test each manipulated the availability of porewater metals within contaminated and uncontaminated sediments. It was predicted that within contaminated sediments, the resin would adsorb porewater metals and reduce toxicity to invertebrates, but in uncontaminated sediments, the resin would not significantly affect these variables. Whereas in the laboratory, the resin produced the predicted results, in the field the resin increased porewater metal concentrations of contaminated sediments for at least 34 days and decreased abundances of four macroinvertebrate groups, and richness in all sediments. These ...

2010-05-01

456

The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo

Anesthetized rats were exposed to 5.6-GHz continuous-wave radiofrequency radiation (RFR) at an average power density of 60 mW/Sq. cm (average specific absorption rate 12 W/kg). Exposure was performed to raise colonic temperature from 38.5 to 39.5C. Following acute administration of chlorpromazine, body temperature exhibited a faster return to baseline temperature when exposure was discontinued. When exposure was initiated at 38.5C and continued until lethal temperature resulted, chlorpromazine-treated animals exhibited significantly shorter survival times than saline-treated animals. Thus, although chlorpromazine enhanced thermoregulatory efficiency at colonic temperature below 39.5 deg C, the drug caused increased susceptibility to terminal RFR. The present results, when compared with previous studies of irradiation at 2.8 GHz, indicate that the effects of chlorpromazine on thermal response to RFR during intermittent and terminal exposure are ...

1988-01-01

457

DEFF Research Database (Denmark)

There is increasing evidence that chemicals/test substances cannot only have adverse effects, but that there are many substances that can (also) have a beneficial effect on health. As this journal regularly publishes papers in this area and has every intention in continuing to do so in the near future, it has become essential that studies reported in this journal reflect an adequate level of scientific scrutiny. Therefore a set of essential characteristics of studies has been defined. These basic requirements are default properties rather than non-negotiables: deviations are possible and useful, provided they can be justified on scientific grounds. The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo concern the following areas: (1) Hypothesis-driven study design; (2) The nature of the test substance; (3) Valid and invalid test ...

2003-01-01

458

Structural adaptation and intracortical bone turnover in an ovine model of osteoporosis.

SE and I content in military total diet

Compact bone makes up approximately 80% of the human skeletal mass. This study examines the effect of estrogen deficiency on compact bone turnover and associated geometrical structural adaptation over a 31-month period in a large animal model. Twenty-seven skeletally mature sheep were divided into control (n = 16) and ovariectomy group (OVX, n = 11). Animals were administered five different fluorochrome dyes to label intracortical bone turnover, and sacrificed at 31 months. Compact bone samples were analyzed for cortical geometry, intracortical turnover at five time points, resorption cavities, porosity, and compressive strength. Intracortical bone turnover was significantly increased in OVX, which demonstrated seasonal variation. Cross-sectional area in OVX was significantly greater than control and was associated with an increased section modulus. Intracortical porosity was significantly increased in OVX, however, there was no significant ...

2010-02-01

459

Radiation induced micrencephaly in guinea pigs

Selenium and iodine are trace elements that play an important role in health of man and animals. Concerning supply of both elements it is important to meet nutritional needs. According to discoveries selenium is a part of an active group of glutathione peroxidase enzyme. It prevents necrotic changes in liver, muscle dystrophy and has impact on growth. Extensive studies on content of selenium in plant and animal origin products were started in the beginning of the seventies in Western Europe (Frankenberger, et al., 1998). The aim of our work was to determine selenium and iodine content in total diets of Slovene military. Slovene military nutrition is based on its own nutritional standards, which determine 200 #mu#g of iodine and 50 #mu#g of selenium in daily diet (Rep. Slovenija Ministrstvo za Obrambo, 1994). To determine if the amounts of both elements meet the standards we have analysed 20 total daily diets from four different barracks within ...

2003-06-10

460

Quantification of the local glucose utilization and local blood flow in the heart of the awake rat using the /sup 14/C-2-deoxyglucose and /sup 14/C-iodoantipyrine methods

A brain weight deficit of about 70 mg was induced at doses of approximately 75-mGy and a deficit of 60 mg was induced at 100 mGy. This confirms the effects projected and observed by Wanner and Edwards. Although the data do not demonstrate a clear dose-response relationship between the 75-mGy and 100-mGy groups, the data are statistically consistent with a dose-response effect because of the overlapping confidence intervals. The lack of a statistically significant observation is most likely related to the small difference in doses and the limited numbers of animals examined. There are several factors that can influence the brain weight of guinea pig pups, such as caging and housing conditions, the sex of the animal, and litter size. These should be taken into account for accurate analysis. Dam weight did not appear to have a significant effect. The confirmation of a micrencephalic effect induced x rays at doses of 75-mGy during this late ...

2006-04-20

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461

Photoperiodic regulation of body mass and fat reserves in the meadow vole.

Local cardiac glucose utilization (LCarGU) was quantified in the rat heart according to the Sokoloff model and local cardiac blood flow (LCarBF) according to the /sup 14/C-iodoantipyrine method. For quantitative autoradiography calibration curves for heart slices were performed. They differed from the brain calibration curves by 8%. The lumped constant was 0.377 in isolated working hearts. LCarGU and LCarBF could then be quantified in awake rats. At different locations mean LCarGU of different hearts varied from 85 to 200 ..mu..moles/100g/min and mean LCarBF from 390 to 831 ml/100g/min. The ratio subendocardial/subepicardial glucose utilization or blood flow was not systematically different from 1. The results indicate that glucose can be an important fuel in the heart of the awake rat, although its contribution to overall metabolism varies from animal to animal.

1986-03-05

462

Phantom and animal imaging studies using PLS synchrotron X-rays

Short photoperiods reduce both body mass and food intake of male meadow voles. To help determine whether the primary effect of short day lengths is on regulation of some component of body mass or on the control of food consumption, voles housed in a long photoperiod were provided rations equivalent to those consumed by animals in short day lengths. Animals were transferred to a short photoperiod and after either 3 or 6 weeks of food restriction were fed ad lib. Both groups of voles overate after termination of food restriction and achieved seasonally appropriate body masses that were influenced by the duration of short photoperiod treatment. We conclude that short photoperiods gradually alter the regulated level of one or more components of body mass. We tested and failed to support the hypothesis that the subcutaneous fat depot is selectively spared during seasonal weight loss and thereby increases surface insulation. Thus, the proportion of ...

1986-01-01

463

CERN Document Server

Ultra-high resolution radiographs can be obtained using synchrotron X-rays. A collaboration team consisting of K-JIST, POSTECH and YUMC has recently commissioned a new beamline (5C1) at Pohang Light Source (PLS) in Korea for medical applications using phase contrast radiology. Relatively simple image acquisition systems were set up on 5C1 beamline, and imaging studies were performed for resolution test patterns, mammographic phantom, and animals. Resolution test patterns and mammographic phantom images showed much better image resolution and quality with the 5C1 imaging system than the mammography system. Both fish and mouse images with 5C1 imaging system also showed much better image resolution with great details of organs and anatomy compared to those obtained with a conventional mammography system. A simple and inexpensive ultra-high resolution imaging system on 5C1 beamline was successfully implemented. The authors were able to acquire ultra-high resolution ...

2001-01-01

464

Mental time travel and the evolution of the human mind.

Long-term effects of prenatal x-ray of human females: reproductive experience

This article contains the argument that the human ability to travel mentally in time constitutes a discontinuity between ourselves and other animals. Mental time travel comprises the mental reconstruction of personal events from the past (episodic memory) and the mental construction of possible events in the future. It is not an isolated module, but depends on the sophistication of other cognitive capacities, including self-awareness, meta-representation, mental attribution, understanding the perception-knowledge relationship, and the ability to dissociate imagined mental states from one's present mental state. These capacities are also important aspects of so-called theory of mind, and they appear to mature in children at around age 4. Furthermore, mental time travel is generative, involving the combination and recombination of familiar elements, and in this respect may have been a precursor to language. Current evidence, although indirect or based on anecdote ...

1997-05-01

465

High performance materials and precious substances made out off renewable substances, specially animal substances. Final report; Hochleistungswerkstoffe und -wertstoffe aus nachwachsenden Rohstoffen, insbesondere aus tierischen Substanzen. Abschlussbericht

A cohort of singleton black human females exposed to diagnostic x-ray in utero and controls matched by parity, hospital of birth and birthdate have been followed to ages 25 to 30 years in Baltimore, Maryland. The search for possible effects of prenatal irradiation has focused on health, growth, development, and reproductive experience of exposed and control women. This paper reports findings related to reproductive experience. From an original data set of 1458 matched exposed-control pairs of women, questionnaire responses were received from 1109 exposed and 1124 control women including 852 each from pairs in which both the exposed and control woman responded. After careful search for alternative explanations of the findings, the authors concluded that females exposed in utero to low doses of x-ray (probably 1 to 5 rads) had significant increases in their rates of early onset of menses, births at age 15 years or less, numbers of living children, stillbirths, and sterilizing operations ...

1981-09-01

466

Further evidence supporting the concurrent influence of aflatoxin and manganese

Basic research in relation to a complete utilisation of animal substances as an alternative to a thermal disposal was done. The composition of different kinds of bones were investigated as well as their amounts which are available. Conventional utilisation was opposed to the innovative utilisation. Technologies will be selected which should be developed, because they have the chance in the case of a fast industrial realisation to get a good profit. There is a global requirement for the technologies which are developed and their products which can be produced with this. The raw material basis is available in the necessary scale in nearly all countries. (orig.) [German] Grundlegende Untersuchungen zur ganzheitlichen Verwertung von tierischen Substanzen als Alternative zur thermischen Entsorgung wurden durchgefuehrt. Es wurde die Zusammensetzung der verschiedenen Knochenarten und ihr Aufkommen untersucht. Die konventionelle wurde der innovativen Verwertung ...

2003-05-08

467

Fermented empty fruit bunch (FEFB) as feed for ruminant animal

Trace elements, including manganese may afford protection from deleterious effects of aflatoxin. Young male Fischer rats received ip injections of aflatoxin B1 (AFB1) in dimethyl sulfoxide (DMSO), 1 mg/kg, 2 mg/kg or 4 mg/kg. Control groups received DMSO ip or no injection. All animals were intubated with 3 microCi of (/sup 54/Mn)-MnCl/sub 2/ 12 hr post-injection. Sacrifice occurred 72 hr after gavage of the radiolabel. All tested levels of AFB1 affected the loss of total body radioactivity. This response was observed within 12 hr when toxin-treated groups excreted almost 4 times more counts than controls. From 12-36 hr following radiolabel administration, AFB1 appeared to enhance excretion; by 72 hr, toxin-treated animals (especially those receiving higher doses) appeared to conserve the metal. Aflatoxicosis manifested itself through reduced body weight gain. The data provide support evidence that Mn and AFB1 biointeract.

1987-04-01

468

Fabrication and animal experiment of nanocomposites of hydroxyapatite collagen and polysaccharides

Fermented oil palm empty fruit bunch, now known as 'Sterifeed' has been characterized by physico-chemical properties. It has also been proven to have an improved digestibility (by in vitro and in-vivo test) over the original material. The remaining important aspect of feed to be examined is the long term effect of feeding this material to animals. The size of fermentation media bags used was 0.5 - 1 kg/bag. In the large scale production of these materials, the numbers of bags were increased. The production at pilot scale level reinvestigated the basic processing parameters for the 1 kg/bag media and also performed a trial run for different sizes of bags. These include: 1) investigation on the growth of fungi on fermentation media subjected to different treatment times and the non treated media, 2) evaluation of the processing rate, 3) trial run processing of 25-50 MT oil palm EFB into feed, and 4) processing of different sizes of bags

1998-01-01

469

Effect of planktivores, zooplankton, and macrobenthos on material flow in a small lake

Four species of nanocomposites organized by hydroxyapatite (HAp), hyaluronic acid (HyA), chondroitin sulfate (ChS) and type II collagen (Col), i.e. HAp/HyA, HAp/ChS, HAp/HyA/Col and HAp/ChS/Col composites, were synthesized by coprecipitation methods. The composites could retain lots of water: 40%, 32%, 42% and 58% for the HAp/HyA, HAp/ChS, HAp/HyA/Col and HAp/ChS/Col composites, respectively. Transmission electron microscopy observations revealed that the HAp/HyA and HAp/ChS composites consisted of island-like aggregations whose sizes were 300 nm in length and 30 nm in width, and 150 nm in length and 30 nm in width, respectively. In the aggregations, there were many HAp nanocrystals of 20 nm in length, and their c-axes were aligned along the respective polymer molecules through a self-organization process. Animal tests showed that chondrocyte-like cells penetrated into the HAp/ChS/Col composites 4 weeks after implantation. It was shown that the HAp/ChS/Col ...

2001-07-01

470

Effect of irradiation on bone remodelling and the structural integrity of the vertebral column. Doctoral thesis

Planktivores, zooplankton grazers, and macrobenthos were studied to determine how changes in animal community structure may alter the flow of material in Dunham Pond, CT. Chaoborus and chironomid larvae were studied to determine how they affect the flux of matter across the sediment/water interface. This was done by incubating undisturbed cores in situ and relating changes in water chemistry to larval density. The log-transformed flux rates of iron, manganese, and phosphorus were linearly related to larval biomass. Functional groups may be successfully used to predict rates of material flow. Changes in the mass of macroinvertebrates affect the flux rates of redox-active substances across the sediment/water interface. The use of population densities and feeding characteristics to estimate trophic transfer in Dunham Pond indicate that (1) visual planktivory by larval perch may result in overutilization of prey, (2) ambush planktivory by univoltine Chaoborus appears ...

471

Development of farmer field school methodology for smallholder dairy farmers

The effects of therapeutic levels of radiation on the axial properties of the primate vertebral column were studied. Seven male rhesus monkeys (Macaca mulatta) were irradiated with a single does of 1300 cGy to the specific lumbar vertebrae of L2, L3, and L4. Three additional animals served as controls. Radiographs were taken before the radiation treatment and just prior to sacrifice to determine density changes in the bone. The animal subjects were sacrificed 105 days following the radiation exposure. Biomechanical testing was completed on lumbar levels 2 and 3 to identify changes in strength characteristics following radiation treatment. Histomorphometric analysis of lumbar vertebrae level 4 was completed to identify volume and surface density changes as well as cellular changes. Tetracycline, dicarbomethylaminomethyl fluorescein (DCAF), and xylenol orange were used as bone labeling agents to aid in the histomorphometry and to obtain dynamic ...

1990-01-01

472

Biological effects after prenatal irradiation (embryo and fetus) ICRP Publication 90 Approved by the Commission in October 2002

SummaryIntended Outputs: Farmers' priorities in dairy health and production in the smallholder crop dairy production system defined.Methodology for applying FFS approach in the AH/LP setting developed, tested and promoted.Impact assessment of the livestock FFS approach.Establishment of a plan of action for the large-scale implementation including proposals for the Government of Kenya to seek funding.Livestock FFS manual: guidelines and reference material suitable for [continued...]ObjectivesTo adapt and test Farmer Field School (FFS) methodology for animal health and production, focussing upon smallholder dairy farmers.DescriptionProject Background: Dissemination has traditionally been seen by research and extension as finding effective ways of transferring technology, and passing on relevant, usable information to farmers. In complex situations, where farmers need to adjust to a changing situation -such as crop protection, soil nutrient management, ...

2006-01-30

473

Biodrying of animal slaughterhouse residues and heat production

In its 1990 recommendations, the ICRP considered the radiation risks after exposure during prenatal development. This report is a critical review of new experimental animal data on biological effects and evaluations of human studies after prenatal radiation published since the 1990 recommendations. Thus, the report discusses the effects after radiation exposure during pre-implantation, organogenesis, and fetogenesis. The aetiology of long-term effects on brain development is discussed, as well as evidence from studies in man on the effects of in-utero radiation exposure on neurological and mental processes. Animal studies of carcinogenic risk from in-utero radiation and the epidemiology of childhood cancer are discussed, and the carcinogenic risk to man from in-utero radiation is assessed. Open questions and needs for future research are elaborated. The report reiterates that the mammalian embryo and fetus are highly radiosensitive. The nature ...

474

Bioavailability of lead in rats fed human diets

Animal carcasses from slaughterhouses are usually composted on farms, but the composting process is not optimized and a large volumes of carbonaceous residues are needed. This type of composting takes place over a period of 6 to 9 months in a nonaerated static pile. Quebec's industrial research centre (CRIQ) developed an organic biodrying process (BIOSECO) adapted to large-scale operations in order to optimize the treatment of slaughterhouse residues. Biodrying is a form of composting, in which the thermophilic phase is optimized, making it possible to evaporate large amounts of water. Biodrying is done inside a building and reduces the amount of carbonaceous residues considerably. The process is optimized by the sequence in which the slaughterhouse residues are added, the choice of input and the aeration flow. Slaughterhouse residues can be treated non-stop throughout the entire year. Since the odours are nearly completed limited to the building, the ...

2010-07-01

475

Animal models of ionizing-radiation damage. Technical report, 18 May 88-18 May 91

The bioavailability of lead was studied in rats fed various baby foods (Babymix-turkey, Babymix-vegetables, Frutolino-fruit, Frutamix-bananas, Babyron-S-26, Truefood), cow's milk, bread, liver and standard rat diet. Lead absorption was determined by measuring the whole body retention of "2"0"3Pb 6 days after a single oral application. Highest absorption values ranging from 17 to 20% were obtained in animals fed cow's milk and fruit foods. Rats on other human diets absorbed between 3 and 8% of the radioactive lead dose. Only in animals on rat diet lead absorption was below 1%. It is concluded that rats fed human diets show absorption values similar to those in humans. This might indicate that the bioavailability of lead is primarily dependent on dietary habits. This experimental model, if confirmed by further work, might be useful for obtaining preliminary data on the bioavailability of metals from various foods.

476

Action Potentials in a Giant Algal Cell: A Comparative Approach to Mechanisms and Evolution of Excitability

This report is a survey of the English language literature of radiation biology between 1947 and 1987, for the purpose of compiling a literature base on the effects of radiation on animals, which have yielded results that can expand our knowledge about similar radiation effects on human beings. Articles were sought that reported exposure of adult mammals to external sources of ionizing radiation, having endpoints that included effects on the brain, the spinal cord, and behavior of the gastrointestinal, endocrine, and cardiovascular systems and the hematopoietic and immune systems. Effects of interest were those that occurred within the first 12 months after exposure. The survey does not include articles reporting chronic or long term delayed effects of radiation unless they provided insight into mechanisms of morphological and/or functional derangement. Information presented in the report is divided into subtopics (i.e., Brain-Morphological Changes). The brief ...

1992-01-01

477

The giant alga Chara corallina generates action potentials (APs) in response to mechanical stimulation, injury, or direct electrical stimulation. Students examine the waveform characteristics of these APs using standard intracellular recording techniques. Intracellular recording is easier than with neurons because of the large size of the Chara cell. Students observe very negative resting potentials (up to -250 mV), large AP amplitudes with depolarizing peaks approaching 0 mV, AP durations of seconds, and refractory periods up to several minutes. Students calculate Nernst potentials for the ions distributed across the Chara cell membrane to hypothesize the ions responsible for the resting potential and for the depolarizing phase of the AP. These calculations suggest that K+ is responsible for the resting potential and that Ca2+ influx and Ca2+-activated Cl- efflux are responsible for depolarizing phases of the AP, which they are. Comparison of the Chara AP characteristics with ...

2008-06-11

478

Wetlands stewardship

Understanding the Conundrum of Rebirth Experience of the Beaver, Gitxsan, and Witsuwit'en

Wetlands have important ecological values and functions. It is estimated that 80 percent of the Nation's coastal fisheries are dependent on wetlands for spawning, nursery areas, and food sources. Both coastal and inland wetlands provide essential breeding, nesting, feeding, and predator escape habitats for millions of waterfowl, other birds, mammals, and reptiles. Well over one-third of the 564 plant and animal species listed as threatened or endangered in the United States utilize wetland habitats during some portion of their life cycle. Wetlands Stewardship is intended as a resource for everyone interested in wetlands protection.

1992-04-01

479

British Library Electronic Table of Contents (United Kingdom)

Summary The First Nations people of British Columbia experience reincarnation as a revitalization of their culture. This article documents the perseverance of reincarnation experiences among the Beaver, Witsuwit'en, and Gitxsan peoples of British Columbia, as well as my own growth in understanding such experiences. It recounts examples of rebirth cases. It explains what rebirth experiences mean to the First Nations people. It describes how these experiences are embedded in their perception of this world and embodied in their beliefs of spiritual realms, which include the interconnected and parallel worlds of fish and land animals, on this world and in spiritual dimensions. While the rebirth worldview contrasts with that of the Western scientific world, this is a worldview I have come to en...

2010-01-01

480

Treatment of bitumina and allied substances. [Cracking

The MHC molecules of nonmammalian vertebrates.

A method of treating bitumina and allied substances of asphaltose character includes heating the material to be treated with up to 25% of its weight of a substance of the group consisting of vegetable and animal oils and fats and fatty acids. The resulting material is heated to a temperature of about 250/sup 0/C under sufficient pressure to prevent the material escape of sulfur dioxide from the reaction mixture in the presence of a substance of the group consisting of inorganic acids of sulfur containing at least 4 oxygen atoms and their anhydrides. The heating is continued until there is no free acid left in the reaction mass.

1937-06-28

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481

DEFF Research Database (Denmark)

There is very little known about the long-term evolution of the MHC and MHC-like molecules. This is because both the theory (the evolutionary questions and models) and the practice (the animals systems, functional assays and reagents to identify and characterize these molecules) have been difficult to develop. There is no molecular evidence yet to decide whether vertebrate immune systems (and particularly the MHC molecules) are evolutionarily related to invertebrate allorecognition systems, and the functional evidence can be interpreted either way. Even among the vertebrates, there is great heterogeneity in the quality and quantity of the immune response. The functional evidence for T-lymphocyte function in jawless and cartilagenous fish is poor, while the bony fish seem to have many characteristics of a mammalian immune system. The organization and sequence of fish Ig genes also indicate that important events in the evolution of the immune system and the MHC ...

1990-01-01

482

Tetracycline in uranyl nitrate intoxication: Its action on renal damage and U retention in bone

Study of the effects of a prenatal or postnatal irradiation of 150 rads in adult rats

In acute intoxication, uranium (U) not only inhibits bone formation but its excretion in urine also causes renal damage. The former effect is ameliorated by tetracycline (TC), probably due to its chelation property, which might also prevent U deposition in bone. Chemical determination of U incorporated in bone and a histological study of the kidneys were performed on animals injected with U and then treated with TC. The results showed that TC was unable to prevent the binding of U to bone while it exacerbated U-induced renal damage.

1989-09-01

483

Study of somatic radiation effects in environment

Pregnant females and newborn rats were exposed to a gamma irradiation of 150 rads. The stage of gestation at the time of irradiation varied from 14 to 21 days. The newborn rats were irradiated at 0, 1 and 2 days of age. The effect of irradiation of foetus and newborn rats depends on the age of the animal at the time of irradiation. This effect was specially important at the beginning of the foetal life. Neonatal mortality, growth of body weight and adult brain development were investigated. A modification of germ cell radiosensitivity during the period studied, was emphasized.

484

Multicellular level dosimetry and low dose rate effects

A survey is presented of the consequences of the irradiation of the population with ionizing radiation. There is an increased incidence of leukemia in irradiated population groups. Among the inhabitants of Hiroshima and Nagasaki maximum death of leukemia was observed in the years 1951 to 1952. The results are summed up of the observation of carcinoma of the breast, lungs and bronchi, bones, and carcinoma of the thyroid. The effect of radiation on experimental animals is described. It was found that the scatter of the dependence of the incidence of various types of cancer on the dose equivalent apparently reflects differences in the biological mechanism of this incidence and that a proportional relationship cannot be expected between the primary damage of cells during irradiation and the actual manifestation of the disease. (E.S.).

485

How can I reuse or recycle chicken feathers? | How can I recycle this?

Building on the concepts of MIRD methods described by Webber, Watson and others at this Symposium on the Dosimetry of Administered Radionuclides, we will now consider how to apply these principles to several experimentally based open-quote macroclose quotes and multicellular models. Specifically, methods to calculate absorbed dose using different types of particulate emission (alpha, beta) with a variety of antibody carriers (IgG, F(ab')_2, Fab) for radioimmunotherapy (RIT) will be reviewed. Additionally, a discussion of direct measurement methods at the multicellular level will reveal the problems of tumor absorbed dose heterogeneity when applied to animal and clinical studies.

1989-09-21

486

Endomicroscopy imaging of epithelial structures using tissue autofluorescence

...On Friday night, we killed, plucked & butchered two chickens. As you do. To be accurate, the wonderful John B and my ...John did the killing, then my John's animals,chicken feathers,feathers,recycling,reusing How can I reuse or recycle chicken feathers? | ...About Archives Suggest an item Contact How can I reuse or recycle chicken feathers? By louisa on 26 Apr 2010 | 7 ...On Friday night, we killed, plucked & butchered two chickens. As you do. To be accurate, the wonderful John B and my ...

487

Bactericidal effects of non-thermal argon plasma in vitro, in biofilms and in the animal model of infected wounds.

We explore autofluorescence endomicroscopy as a potential tool for real-time visualization of epithelial tissue microstructure and organization in a clinical setting. The design parameters are explored using two experimental systems--an Olympus Medical Systems Corp. stand-alone clinical prototype probe, and a custom built bench-top rigid fiber conduit prototype. Both systems entail ultraviolet excitation at 266 nm and/or 325 nm using compact laser sources. Preliminary results using ex vivo animal and human tissue specimens suggest that this technology can be translated toward in vivo application to address the need for real-time histology.

2011-04-01

488

Animal experiments on the biokinetics of astatide and astate-(I)-complex compounds

Non-thermal (low-temperature) physical plasma is under intensive study as an alternative approach to control superficial wound and skin infections when the effectiveness of chemical agents is weak due to natural pathogen or biofilm resistance. The purpose of this study was to test the individual susceptibility of pathogenic bacteria to non-thermal argon plasma and to measure the effectiveness of plasma treatments against bacteria in biofilms and on wound surfaces. Overall, Gram-negative bacteria were more susceptible to plasma treatment than Gram-positive bacteria. For the Gram-negative bacteria Pseudomonas aeruginosa, Burkholderia cenocepacia and Escherichia coli, there were no survivors among the initial 10(5) c.f.u. after a 5 min plasma treatment. The susceptibility of Gram-positive bacteria was species- and strain-specific. Streptococcus pyogenes was the most resistant with 17?% survival of the initial 10(5) c.f.u. after a 5 min plasma treatment. Staphylococcus aureus had a ...

2010-09-09

489

Use of experimental animals. Commentaries - project reports - literature reviews. Selected examples from the `In-vitro-Systeme` newsletter published from 1986-1993; Zum Ersatz von Tierversuchen. Kommentare - Projektberichte - Literaturbesprechungen. Ausgewaehlte Beitraege aus dem Informationsblatt `In-vitro-Systeme` 1986-1993

The radiation properties of the #alpha# emitter "2"1"1At are in favor of its application malignant tumor therapy. As a basis for further investigations the biokinetics of At"-, At x H_2O, At I_2"-, and [At(thio)_2]"+ were determined after i.v. injection into healthy and tumor-bearing mice. The estimation of the ion mobility of the carrier-free compounds allowed the use of uniquely characterized initial compounds. The organ distribution of all species examined was similar to the distribution of astatide. Accumulation was found in the thyroid and other inner organs. (author).

490

Sodium arsanilate-induced vestibular dysfunction in meadow voles (Microtus pennsylvanicus): effects on posture, spontaneous locomotor activity and swimming behavior.

Numerous task forces at universities, other research institutions and in industry have been concerned with the development of methods fit to replace animal experiments. A great many useful in-vitro test systems were developed. From 1986 to 1993 the ``In-vitro Systems`` newsletter was published with the support of the federal ministry of science and technology. Its purpose was to intensely promote the concept of in-vitro systems for the benefit of experimental animals among scientists, and to demonstrate to the public the limits of such endeavours. This brochure is a compilation of 141 contributions from all annual volumes, dealing inter alia with research projects for the development of pharmaceuticals, toxicology and quality control, ethic-philosophical considerations, meeting reports, and book reviews. Changes or revisions have not been made; so some of the contributions have been overtaken by more recent developments. (MG) [Deutsch] Viele ...

1994-12-31

491

Influence of sedation and data acquisition method on tracer uptake in animal models: ["1"2"3I]-2-iodo-L-phenylalanine in pentobarbital-sedated tumor-bearing athymic mice

Vestibular dysfunction was chemically induced in male meadow voles (Microtus pennsylvanicus) by intratympanic injections (30 mg per side) of sodium arsanilate (atoxyl). The control group received intratympanic injections of isotonic saline. After a one-week recovery period the voles were behaviorally assayed for integrity of their labyrinthine systems. All subjects were tested for the presence of the air-righting reflex and body rotation-induced nystagmus. Three weeks later a multivariate assessment of spontaneous motor activity of the voles was carried out in the automated Digiscan Activity Monitor. In addition, the swimming behavior of the voles was examined. Voles with vestibular dysfunction exhibited pronounced postural abnormalities (head dorsiflexion), were not able to swim with their nose above the water for a 1 min test period, and displayed disorientation and thrashing movements. In the Digiscan activity test the atoxyl-treated voles displayed significantly more activity in ...

1992-03-15

492

Escape behaviour in the stomatopod crustacean Squilla mantis, and the evolution of the caridoid escape reaction.

Objectives: To minimize movement artifacts during tracer imaging studies, the animals are generally sedated. Although many reports describe the effect of barbiturates on brain function, less is published about the general impact on the extracerebral metabolism and tracer biodistribution. This report describes the influence of pentobarbital on tumor uptake of ["1"2"3I]-2-iodo-L-phenylalanine (["1"2"3I]-2I-L-PA) using dissection and nuclear imaging. Methods: R1M tumor-bearing athymic mice were divided into two populations: untreated and pentobarbital-treated. Each group was subjected to dynamic and static planar imaging and organ dissection after ["1"2"3I]-2I-L-PA injection. Two-compartment blood modeling was performed. Analysis of variance (ANOVA), t test and clustered boxplot analyses were used to compare the results between the treatment groups and between the data acquisition methods. Results: Two-compartment blood modeling demonstrated that pentobarbital ...

2006-01-01

493

Differential effects of chronic ingestion of tritiated water on prenatal brain development

The mantis shrimp Squilla mantis shows a graded series of avoidance/escape responses to visual and mechanical (vibration and touch) rostral stimuli. A low-threshold response is mediated by the simultaneous protraction of the thoracic walking legs and abdominal swimmerets and telson, producing a backwards 'lurch' or jump that can displace the animal by up to one-third of its body length, but leaves it facing in the same direction. A stronger response starts with similar limb protraction, but is followed by partial abdominal flexion. The maximal response also consists of limb protraction followed by abdominal flexion, but in this case the abdominal flexion is sufficiently vigorous to pull the animal into a tight vertical loop, which leaves it inverted and facing away from the stimulus. The animal then swims forward (away from the stimulus) and rights itself by executing a half-roll. A bilaterally paired, large-diameter, ...

2000-01-01

494

Diagnostic and therapeutic evaluation of "1"1"1In-vinorelbine-liposomes in a human colorectal carcinoma HT-29/luc-bearing animal model

Female rats were given tritiated drinking water (3 microCi/ml) from 30 days before mating up to and throughout pregnancy. At this low dose, the course and the outcome of pregnancy were normal. The differences between newborn body and cerebral weights of the treated rats and those of control animals were on the borderline of significance. In contrast, cerebral DNA and cerebral protein were highly significantly lower. In 30-35% of the treated population the DNA and protein values were more than 2 standard deviations (SD) below the mean values for the control population. Thus the number of the progeny of the mothers exposed to tritiated water that were considered to have outstandingly low levels of DNA and protein was 14-17 times greater than in the control group. The irradiated population also had 3-5% of severely affected individuals with cerebral DNA and protein values more than 2 SD below the mean of the experimental population. However, even in this irradiated ...

495

Computerized tomography-guided neurolytic splanchnic nerve block

Colorectal carcinoma is a highly prevalent and common cause of cancer in Taiwan. There is still no available cure for this malignant disease. To address this issue, we applied the multimodality of molecular imaging to explore the efficacy of diagnostic and therapeutic nanoradiopharmaceuticals in an animal model of human colorectal adenocarcinoma [colorectal cancer (CRC)] that stably expresses luciferase (luc) as a reporter. In this study, an in vivo therapeutic efficacy evaluation of dual-nanoliposome (100 nm in diameter) encaged vinorelbine (VNB) and "1"1"1In-oxine on HT-29/luc mouse xenografts was carried out. HT-29/luc tumor cells were transplanted subcutaneously into male SCID mice. Multimodality of molecular imaging approaches including bioluminescence imaging (BLI), gamma scintigraphy, whole-body autoradiography (WBAR) and in vivo tumor growth tracing, histopathology and biochemistry/hematology analyses were applied on xenografted SCID mice to study the ...

2008-07-01

496

A study of relative regional cerebral blood flow using N-isopropyl-p-["1"2"5I]-iodoamphetamine ("1"2"5I-IMP) in carbon monoxide exposed rats

Computerized tomography-guided neurolytic splanchnic nerve block is a technique for relieving abdominal cancer pain; the goal is the alcoholic neurolytic interruption of the sensitive structures in retroperitoneal space. Computerized tomography yields accurate anatomical detailing and the course for needle placement and alcohol spread. January, 1993, to July, 1996, twenty-one bilateral splanchnic nerve blocks were performed through the posterior access. Forty-eight hours after alcoholism. 14 patients (66%) had complete pain regression; 52% of the patients needed no analgesics for 6 to 54 days and only 9 patients (42%) needed another low opioid therapy. Complications included hypotension and diarrhea in all cases. One had a cardiac arrest and diet 8 days after the procedure. There were no other complications. The whole procedure usually lasted 60 min (range: 45 to 90 min). Splanchnic nerve neurolysis is a useful treatment in the patients with severe chronic abdominal pain. It is used as ...

1997-01-01

497

A study of relative regional cerebral blood flow using N-isopropyl-p-( sup 125 I)-iodoamphetamine ( sup 125 I-IMP) in carbon monoxide exposed rats

The influence of carbon monoxide (CO) exposure on regional cerebral blood flow (r-CBF) in rat brain was studied using autoradiography and "1"2"5I-IMP. Fuji computed radiography (FCR) was used to obtain improved autoradiograms in this study. R-CBF was determined in a relative measure by calculating hippocampus/cortex and putamen/cortex ratios of RI accumulation from the autoradiogram using a densitometer. Comparison of autoradiograms with pathological findings in the area of the hippocampus and putamen yield the following results. In the animals that were exposed to 6400 ppm or 10000 ppm of CO for 30 minutes, and then were followed up for 2 weeks without further exposure, r-CBF was decreased but no pathological changes occurred. In the animals that were exposed to 6400 ppm or 10000 ppm of CO, and then were followed up for 4 weeks without further exposure, pathological changes appeared. In animals exposed to 3200 ppm of CO, ...

498

A high-sensitivity small animal SPECT system

The influence of carbon monoxide (CO) exposure on regional cerebral blood flow (r-CBF) in rat brain was studied using autoradiography and {sup 125}I-IMP. Fuji computed radiography (FCR) was used to obtain improved autoradiograms in this study. R-CBF was determined in a relative measure by calculating hippocampus/cortex and putamen/cortex ratios of RI accumulation from the autoradiogram using a densitometer. Comparison of autoradiograms with pathological findings in the area of the hippocampus and putamen yield the following results. In the animals that were exposed to 6400 ppm or 10000 ppm of CO for 30 minutes, and then were followed up for 2 weeks without further exposure, r-CBF was decreased but no pathological changes occurred. In the animals that were exposed to 6400 ppm or 10000 ppm of CO, and then were followed up for 4 weeks without further exposure, pathological changes appeared. In animals exposed to 3200 ppm of ...

1990-11-01

499

Contamination by depleted uranium (Du) in South Serbia

Medical imaging using single gamma-ray-emitting radionuclides typically makes use of parallel hole collimators or pinholes in order to achieve good spatial resolution. However, a tradeoff in sensitivity is inherent in the use of a collimator, and modern preclinical single photon emission computed tomography (SPECT) systems detect a very small fraction of emitted gamma rays, often less than 0.1%. A system for small animal SPECT imaging which uses no collimators could potentially achieve very high sensitivity-several tens of percent-with reasonably sized detectors. This would allow two significant improvements in preclinical studies: images could be obtained more rapidly, allowing higher throughput for screening applications, or for dynamic processes to be observed with very good time resolution; and images could be obtained with less radioactive tracer, making possible the in vivo imaging of low-capacity receptor systems, aiding research into new tracer compounds, ...

2009-03-07

500