Energy Technology Data Exchange (ETDEWEB)

The key to the future for electric utilities will not be found in legislation or regulation. Title VII of the Energy Policy Act of 1992 will prove to be just as ineffectual in improving the industry's position as was the Public Utility Regulatory Policies Act of 1978. These legislative palliatives, which produced so much commotion and so many reams of heated commentary, are largely irrelevant to a successful future for electric utilities. The key will be found in economics, not in law, and the future will lie in completing Thomas A. Edison's century-old vision for the industry, half of which the industry has heretofore ignored. The industry must embrace the complete vision and evolve from electric utilities into [open quotes]end-use energy utilities.[close quotes

UK PubMed Central (United Kingdom)

AMP-activated-protein-kinase (AMPK) is a key sensor and regulator of cellular and whole-body energy metabolism and plays a key role in regulation of lipid metabolism. Since lipid metabolism...Full Text Available

UK PubMed Central (United Kingdom)

A positive, genetic selection against the activity of the nitrogen regulatory (NTR) system was used to isolate insertion mutations affecting nitrogen regulation in Klebsiella aerogenes. Two classes...Full Text Available

UK PubMed Central (United Kingdom)

The existence of thresholds for toxicants is a matter of debate in chemical risk assessment and regulation. Current risk assessment methods are based on the assumption that, in the absence of sufficient...Full Text Available

UK PubMed Central (United Kingdom)

Hepatocyte nuclear factor (HNF) 4α is a key transcription factor regulating endo/xenobiotic-metabolizing enzymes and transporters. We investigated whether microRNAs are involved in the regulation...Full Text Available

UK PubMed Central (United Kingdom)

SummaryIn vivo tumor cell migration through integrin-dependent pathways is key to the metastatic behavior of malignant cells. Using quantitative in vivo...Full Text Available

UK PubMed Central (United Kingdom)

The establishment of the primary meristems through proliferation after germination is essential for plant post-embryonic development. Cytokinins have long been considered a key regulator of...Full Text Available

UK PubMed Central (United Kingdom)

Stem cells are expected to play a key role in the development and maintenance of organisms, and hold great therapeutic promises. However, a number of questions must be answered to achieve an...Full Text Available

UK PubMed Central (United Kingdom)

AbstractIntrathymic expression of tissue-restricted antigens (TRAs) has been viewed as the key element in the induction of central tolerance and recently, a central role for the autoimmune...Full Text Available

UK PubMed Central (United Kingdom)

Recently, we demonstrated that the central ghrelin signalling system, involving the ghrelin receptor (GHS-R1A), is important for alcohol reinforcement. Ghrelin targets a key mesolimbic circuit involved...Full Text Available

UK PubMed Central (United Kingdom)

The mitogen-activated protein kinase/extracellular regulated kinase (MAPK/ERK) pathway plays a key role in mediating estrogen actions in the brain and neuronal sensitization during inflammation....Full Text Available

UK PubMed Central (United Kingdom)

From Toki-shakuyaku-san, an herbal formulation for “cleansing stagnated blood,” a key gene regulatory compound was purified and identified through a screening based on DNA microarray...Full Text Available

UK PubMed Central (United Kingdom)

A structurally conserved element, the trigger loop, has been suggested to play a key role in substrate selection and catalysis of RNA polymerase II (pol II) transcription elongation. Recently resolved...Full Text Available

International Nuclear Information System (INIS)

This paper discusses key methods for sustaining quality engineering data, the fundamental principles that these methods are based on, and the methods for supporting the performance of nuclear power plants by the provision of quality engineering data at all times. The concept of an 'engineering data foundation', and a Configuration Management data model are developed. The concepts and methods for managing the integrity of engineering data across many different databases and document systems are developed, including the key concepts of data-positions and data-values, Master Data and Copy Data, and the concept of a 'partnership between people and technology'. (author). 7 refs., 1 tab., 2 figs.

UK PubMed Central (United Kingdom)

The canonical Wnt/β-catenin pathway plays a pivotal role in regulating embryogenesis and tumorigenesis by promoting cell proliferation. BAMBI (BMP and activin membrane-bound inhibitor) has...Full Text Available

UK PubMed Central (United Kingdom)

Normal brain development requires a series of highly complex and interrelated steps. This process presents many opportunities for errors to occur, which could result in developmental defects...Full Text Available

UK PubMed Central (United Kingdom)

Atg9 is a transmembrane protein essential for autophagy which cycles between the Golgi network, late endosomes and LC3-positive autophagosomes in mammalian cells during starvation through a mechanism...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This document presents the SSI preliminary views and position concerning the decommissioning of nuclear plants. To prevent the exposure of the decommissioning personnel and the general public to unacceptable levels of radiation and to protect the environment and future generations, it is SSI`s task to formulate and issue the necessary terms and regulations with which the reactor licensees must comply during the decommissioning work. The views and principles presented here are the basis of SSI`s continued work on guidelines and regulations for the decommissioning of nuclear plants.

UK PubMed Central (United Kingdom)

Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is an aggressive non-Hodgkin lymphoma of T/null immunophenotype that is most prevalent in children and young adults. The...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Various initiatives have been undertaken by the Federal Energy Regulatory Commission (FERC) to deregulate wholesale electric energy markets. These initiatives have focused on restructuring the transmission systems in the US and recently have culminated in a proposal requiring formation of and participation in regional transmission organizations. The overall form of regulation selected to determine rates for transmission entities as well as underlying regulatory decisions reached on key issues will have profound implications for transmission entities. For example, traditional cost-based regulation would require one set of accounting and reporting rules, while incentive-based regulation may not be subject to those same rules. An overview of some of the major accounting and financial reporting issues that will need to be considered is presented.

Energy Technology Data Exchange (ETDEWEB)

This CD-Rom edited by the French scientific and technical committee of the space heating, ventilation and air-conditioning industry (CoSTIC) presents a series of technical files about ventilation and space heating systems with several references to the current regulatory texts. Modifications of the original legislative texts have been integrated to the original texts for a more comfortable reading. Search is performed using diagrams and key-words. (J.S.)

UK PubMed Central (United Kingdom)

BackgroundMicroRNAs (miRNAs) are important regulators that play key roles in tumorigenesis and tumor progression. A previous report has shown that let-7 family members can act as...Full Text Available

UK PubMed Central (United Kingdom)

Angiotensin II (Ang II) is a key proapoptotic factor in fibrotic tissue diseases. However, the mechanism of Ang-II-induced cell death in endothelial cells has not been previously elucidated....Full Text Available

International Nuclear Information System (INIS)

An imaging position sensitive detector for charged particles, neutrons, X-and gamma rays has been developed. The novel feature of this scintillation imaging radiation detector is its ability to detect individual nuclear particle scintillations with a h igh degree of spatial resolution. The key elements of this detector system are a high gain, low noise image intensifier tube, a CCD camera and commercially available image processing hardware and software. This detector system is highly effective for applications such as low fluence and real time neutron radiography, mapping of radioactive contamination in nuclear reactor fuel rods, X-ray diffraction imaging, high speed autoradiography and in general position sensitive detection of nuclear radiation. Results of some of the exploratory experiments carried out using this detector system are presented in this paper. (orig.).

Science.gov (United States)

Citizens Gas and Coke Utility operates three coke oven batteries, producing both foundry coke and blast furnace coke, under the trade name Indianapolis Coke. Active participation in the regulation negotiation process by the Vice President of Indianapolis Coke allowed the company to accurately anticipate the environmental regulations, long before they were set in law. Several improvements were put into motion that helps them meet the new environmental regulations. Better trained operators with new job positions dedicated solely to environmental compliance, an extensive environmental training program, and two innovations, a portable oven door milling and cleaning machine and three new computer applications are the result of team efforts. The focus of this paper is development of the computer applications designed to enhance three areas of environmental compliance. The three areas addressed by the ...

British Library Electronic Table of Contents (United Kingdom)

PP2B is a Ca2+/calmodulin-dependent protein phosphatase that is ubiquitously expressed in mammals. Among other actions, it is an effector mechanism in NMDA-mediated glutamate neurotransmission as well as a regulator of GSK3? and MAPK signaling cascades. Because all of these mechanisms have demonstrable roles in the control of circadian rhythyms, we hypothesized that PP2B would be a key regulator of rhythm generation and entrainment, and that through inhibition of its phosphatase activity, the circadian system would be affected by immunosuppressant drug therapy. We report here that immunosuppressant drugs (cyclosporin A, FK506) (1) block the circadian responses to light that underlie photic entrainment; (2) produce circadian phase shifts with a characteristic nonphotic profile; and (3) disr...

Science.gov (United States)

Resistance exercise has been widely reported to have positive rehabilitation effects for patients with neuromuscular and orthopaedic conditions. This paper presents an optimal design of magneto-rheological fluid dampers for variable resistance exercise devices. Adaptive controls for regulating the resistive force or torque of the device as well as the joint motion are presented. The device provides both isometric and isokinetic strength training for various human joints.

International Nuclear Information System (INIS)

The current trend towards the increased use of risk assessment in the regulation of nuclear power plants will inevitably result in changes in the analysis of fire protection systems and the methods of analysis. Before fire protection can be regulated on a risk basis, a consensus must be reached on a number of issues. One key issue is what types of computational tools will be allowable for analyzing fire events, and what types of scenarios those tools will be approved for use. Reaching this consensus will require an understanding of the types of computational tools available and their inherent advantages and disadvantages. To aid with this understanding, three different methods of fire simulation are applied to an oil pool fire test in the HDR (Heiss Dampf Reaktor) containment test facility. These methods are a hand calculation, the zone model code CFAST (Consolidated Model of Fire Growth and Smoke Transport), and the ...

British Library Electronic Table of Contents (United Kingdom)

Aims A depressed cGMP-dependent protein kinase (PKG) activity is implicated in nitrate tolerance. The present study determines whether the leucine zipper-positive (LZ+) isoform of myosin phosphatase target subunit 1 (MYPT1), a key target protein for PKG actions, is involved in the development of nitrate tolerance. Methods and results Nitrate tolerance in in vitro preparations was obtained by a 24 h incubation with nitroglycerin (NTG). Nitrate tolerance in in vivo preparations was obtained by subcutaneous injection of mice with NTG, and the aortas were used. Protein levels of total MYPT1, MYPT1 (LZ+), PP1Cd, myosin light chain (MLC), and phosphorylated MLC were determined by Western blot analysis. Isometric vessel tension was determined by an organ chamber technique. Protein levels of MYPT1...

Energy Technology Data Exchange (ETDEWEB)

This paper explores the feasibility of integrating energyefficiency program evaluation with the emerging need for the evaluationof programs from different "energy cultures" (demand response, renewableenergy, and climate change). The paper reviews key features andinformation needs of the energy cultures and critically reviews theopportunities and challenges associated with integrating these withenergy efficiency program evaluation. There is a need to integrate thedifferent policy arenas where energy efficiency, demand response, andclimate change programs are developed, and there are positive signs thatthis integration is starting to occur.

Energy Technology Data Exchange (ETDEWEB)

The ongoing upgrade of the Los Alamos Free-Electron Laser (FEL) Facility involves the addition of a photoelectric injector (PEI) and acceleration capability to about 40 MeV. The electron-beam and high-speed diagnostics provide key measurements of charge, beam position and profile, divergence emittance, energy (centroid, spread, slew, and extraction efficiency), micropulse duration, and phase stability. Preliminary results on the facility include optical transition radiation interferometer measurements of divergence (1 to 2 mrad), FEL extraction efficiency (0.6 {plus_minus} 0.2%), and drive laser phase stability (< 2 ps [rms]). 10 refs.

British Library Electronic Table of Contents (United Kingdom)

During the 1990s, a debate took place in Sweden concerning Conductive Education. Proponents of this method focused their critique on the role and methods of physiotherapists but this profession was not active in the debate. Instead, the medical profession came out as defenders of habilitation services and methods. Departing from sociology of the professions, our objective in this article is to analyze the physiotherapists' silence in relation to the profession's position and its relation to the medical profession. The analysis is based on data from interviews with members of habilitation teams and other key persons, and on documents. The relative silence of physiotherapists is found to be related to both interprofessional factors (the subordination under the medical profession paired with ...

Energy Technology Data Exchange (ETDEWEB)

For the purposes of energy forests, biological pest control should be interpreted as any method of using natural organisms or their products for the regulation of herbivores, below the economic threshold. The organisms include the energy forest crop species and natural enemies of pest herbivores. Examples are provided of three-trophic-level interactions, including some on willows and poplars. Bottom-up effects may be particularly strong in juvenile Salicaceae, which are used in energy forest production, because plants are growing vigorously, and many herbivores respond positively. Some major pests on willows and poplars appear to have weak top-down regulation, and they may be influenced most by bottom-up effects such as plant resistance through genetic variation, ontogenetic aging and physiological aging. Balancing the bottom-up and top-down forces in energy forests may be difficult in short-rotation crops, but harvesting ...

Science.gov (United States)

The parathyroid endocrine glands, usually four in number and about the size of a split pea, lie on either side of the posterior aspect of the thyroid gland. Occasionally one or more of these structures are found in an aberrant position in the neck or even in the superior mediastinum. The parathyroid secretion, parathormone, regulates the level of serum calcium within sharply defined limits. Lack of parathormone, with lowering of the serum calcium, results in hyper-irritability of skeletal muscle, the clinical condition known as tetany. This is encountered following inadvertent removal or bruising of the parathyroid glands at thyroidectomy. PMID:21488463

Energy Technology Data Exchange (ETDEWEB)

To investigate mechanisms responsible for positive and negative transcriptional control, the authors have utilized two types of promoters that are diffferentially regulated by thyroid hormone (T{sub 3}) receptors. Promoters containing the palindromic T{sub 3} response element TCAGGTCA TGACCTGA are positively regulated by the T{sub 3} receptor after the administration of T{sub 3}, whereas otherwise identical promoters containing the estrogen response element TCAGGTCA CTG TGACCTGA can be regulated negatively; converse effects are observed with the estrogen receptor. They describe evidence that the transcriptional inhibitory effects of the T{sub 3} or estrogen receptors on the estrogen or T{sub 3} response elements, respectively, are imposed by amino acid sequences in the C'-terminal region that colocalize with dimerization and hormone-binding domains and that these sequences ...

British Library Electronic Table of Contents (United Kingdom)

Amyloid precursor protein (APP), a key protein in pathogenesis of Alzheimer's disease (AD), is a type I transmembrane protein which can be cleaved by b- and g-secretase to release the amyloidogenic b-amyloid peptides (Ab) and the APP intracellular domain (AICD). While Ab has been widely believed to initiate pathogenic cascades culminating AD, the physiological functions and regulations of AICD remain elusive. In present study, endogenous AICD was demonstrated to be increased by canonical Wnt signal. Instead of due to g-secretase activity, enhanced AICD expression was found due to the increased protein stability by Wnt/b-catenin. b-Catenin was demonstrated to be an associating partner of AICD, capable of promoting AICD mediated transcriptional activity. Investigation by AICD mutants proved ...

International Nuclear Information System (INIS)

The effects of the fluctuations of the Thai economy of the country's petroleum industry and the outlook for the future are discussed. Thailand witnessed enormous economic growth during the 1980s and the first part of the 1990s, but events since 1997 have caused it to stutter. However, the petroleum industry remains buoyant with measures to stimulate gas and oil production and moves to privatise and deregulate energy markets. Key statistics for Thailand, historical demand trends for petroleum, the impact of the 1997 Asian economic crisis, regulation of the Thai oil market, crude and condensate production levels, refinery capacity, new entrants to the refinery sector, the Thai refinery expansion programme, the product trade balance, the challenges of fuel reformulation and demand scenarios are considered.

British Library Electronic Table of Contents (United Kingdom)

Nitric oxide (NO) and related molecules such as peroxynitrite, S-nitrosoglutathione (GSNO), and nitrotyrosine, among others, are involved in physiological processes as well in the mechanisms of response to stress conditions. In sunflower seedlings exposed to five different adverse environmental conditions (low temperature, mechanical wounding, high light intensity, continuous light, and continuous darkness), key components of the metabolism of reactive nitrogen species (RNS) and reactive oxygen species (ROS), including the enzyme activities L-arginine-dependent nitric oxide synthase (NOS), S-nitrosogluthathione reductase (GSNOR), nitrate reductase (NR), catalase, and superoxide dismutase, the content of lipid hydroperoxide, hydrogen peroxide, S-nitrosothiols (SNOs), the cellular level of N...

International Nuclear Information System (INIS)

The paper presents some aspects relating to the importance of a good communication and cooperation between all factors involved in procurement process at Societatea Nationala 'Nuclearelectrica', SNN. In order to comply with the internal and international rules related to safety in nuclear field and public procurement requirements and for maintaining a high standard of operational performance of Cernavoda NPP, adequate procurement systems were developed by SNN SA. The importance of human factor and the training activities for all personnel from this chain of procurement process is the main key issue to maintain high quality of their activities considering that procurement documents are reviewed and approved before to be issued by all departments involved in procurement process. The specialized department for public acquisition is supervising that the procurement processes initiated at the level of branches, in accordance with their needs and with respect to the ...

Energy Technology Data Exchange (ETDEWEB)

Transcriptional regulation of the galactose-metabolizing genes in Saccharomyces cerevisiae depends on three core proteins: Gal4p, the transcriptional activator that binds to upstream activating DNA sequences (UASGAL); Gal80p, a repressor that binds to the carboxyl terminus of Gal4p and inhibits transcription; and Gal3p, a cytoplasmic transducer that, upon binding galactose and adenosine 5'-triphosphate, relieves Gal80p repression. The current model of induction relies on Gal3p sequestering Gal80p in the cytoplasm. However, the rapid induction of this system implies that there is a missing factor. Our structure of Gal80p in complex with a peptide from the carboxyl-terminal activation domain of Gal4p reveals the existence of a dinucleotide that mediates the interaction between the two. Biochemical and in vivo experiments suggests that nicotinamide adenine dinucleotide phosphate (NADP) plays a key role in the initial induction event.

Science.gov (United States)

Drosophila melanogaster has long been at the forefront of studies of transcriptional regulation in animals. Many fundamental ideas--such as cis control elements that act over long distances, the regulation of development by hierarchical cascades of transcription factors, dosage compensation, and position effect variegation--originated from studies of the fruit fly. The recent completion of the euchromatic DNA sequence of Drosophila is another breakthrough. The sequence data highlight important unanswered questions. For example, only one-fifth of the 124 Mb of Drosophila euchromatic DNA codes for protein. The function of the remaining 100 Mb of mostly unique DNA is largely unknown. Some proportion of this non-reading frame DNA must encode the functional recognition sites targeted by the approximately 700 sequence-specific DNA binding proteins that regulate transcription in Drosophila, but what ...

Science.gov (United States)

In an era of unprecedented technological advancement and economic expansion, construction practice continues to evolve but construction education has not changed appreciably since the 1990s. This schism has prompted industry, government, and other key constituents to question the relevancy and efficacy of current programs. The Accreditation Board for Engineering and Technology (ABET) Engineering Criteria 2000 and the American Council for Construction Education (ACCE) emphasizes outcomes over process, and provides an opportunity for stakeholders to help universities define educational goals and objectives and design a curriculum to meet the desired outcomes. While the need for curriculum modification has been acknowledged, the industry position was amorphous and anecdotal and therefore difficult to address. Qualitative methodologies such as formal surveys and structured interviews can be used to capture and quantify industry expectations of the ...

Science.gov (United States)

... Award Number: DAMD17-02-1-0151 TITLE: Paracrine Regulation of Prostatic Carcinogenesis ... Paracrine Regulation of Prostatic Carcinogenesis ...

British Library Electronic Table of Contents (United Kingdom)

Data from the New Immigrant Survey are used to study wealth differentials among U.S. legal permanent residents. This study is unique in its ability to account for wealth held in the U.S. and that held abroad and yields several key findings. First, relative to immigrants from Western Europe, Australia, Canada, and New Zealand (who have median wealth similar to native born non-Hispanic whites), other immigrant groups have lower levels of total wealth even after accounting for permanent income and life course characteristics. Second, time in the U.S. is positively associated with the wealth of married immigrants, yet this relationship is not statistically significant for single immigrants. Third, differences in the means of measured characteristics between Western European immigrants and thos...

Energy Technology Data Exchange (ETDEWEB)

Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatial position and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kicks are reported as a function of charge.

British Library Electronic Table of Contents (United Kingdom)

In this paper, we investigate the relationship between the subprime asset-backed collateralized debt obligations (CDO) market and Large Complex Financial Institutions (LCFIs). We attempt to account for the dynamics between the ABX index returns and the banks' equity returns through conditioning our analysis on the historical correlation between the variables. Three key results emerge from the analysis. First, we find a positive correlation between movements of the ABX index and the equity returns for all the LCFIs. Second, the volatility of ABX index returns tend to be transmitted to the volatilities of the equity returns of the financial institutions. Third, ABX prices changes lead equity returns changes of the European-based LCFIs. For the US LCFIs a two-way linkage emerges.

British Library Electronic Table of Contents (United Kingdom)

This article explores the extent to which and how non-formal education (NFE) contributes to the development of a more diversified basic education system and thus to the achievement of EFA. It outlines the current nature of NFE, the frameworks provided by the EFA movement, and the evolution of reflection, policies and practices in NFE in relation to basic education as a whole. Based on significant developments in various countries across the South, the article also discusses some key challenges that ministries of education and their partners need to face in moving towards relevant and equitable diversity in education. The article posits that, despite the many problems faced by NFE, there is justification for building on its experiences and integrating these within a larger policy and system...

International Nuclear Information System (INIS)

This report presents a view of and commentary on the current status of equipment qualification (EQ) in nuclear industries of the major western nations. The introductory chapters discuss the concepts of EQ, the elements of EQ process and highlight some of the key issues in EQ. A brief review of industry practices and some of the prevalent industrial standards is presented, followed by an overview of current regulatory positions in the USA, France, Germany and Sweden. A summary and commentary on the latest research findings on issues relating to accident simulation, to aging simulation and some special topics related to EQ, has been contributed by Franklin Research Centre of Philadelphia. The last part of the report deals with equipment qualification in Canada and gives recommendations on EQ for new plants as well as currently operational CANDU nuclear power plants.

International Nuclear Information System (INIS)

X-ray diffraction enhanced imaging (DEI) is one of X-ray phase-contrast imaging methods, which is applied to inspect internal structures of weakly absorbing low-Z samples. The key problem of the DEI is how to extract phase information which is expressed by refraction-angle images from a series of DEI images measured in different positions of the rocking curve of the analyzer. Three effective extraction methods are presented in this paper: the statistical geometric-optics-approximation method, the maximum refraction-angle method and the Gaussian curve fitting method. They are compared with the existing methods, such as the D. Chapman's geometric optics approximation method and the multiple-images statistical method. A 2D computer simulation experiment is performed to draw comparisons of these methods. The experimental results prove that the above three methods have more precision of refraction-angle values than existing methods.

British Library Electronic Table of Contents (United Kingdom)

For early-stage firms, successful commercialization of each new product is critically important, given the shortage of financial resources, the limited product portfolio, and small staffs typical of such firms. This paper investigates two key contributing factors for new product success in entrepreneurial firms: designing products that are appealing to target users in both form and function and designing products that can be manufactured at an attractive margin so that the new enterprise can generate much needed positive cash flow. These two practices-industrial design and cost engineering-are well studied in the context of larger, established corporations but have not been explored in the context of new ventures. This study focuses on the intensity of individual and combined adoption of d...

International Nuclear Information System (INIS)

In the beginning of 2005 several changes in the electricity and natural gas market law came into effect. This report examines the influence and impact of these changes on the behaviour and development of these markets, looking at the role and position of both the energy industry and customers. The report combines existing data with new research data collected during spring and summer 2006. Whilst the recency of the law changes, along with the simultaneous impact of other market variables limits the salience of any impact, the report nevertheless provides clear and interesting conclusions. In the electricity market, one major legislative change that came into force in the beginning of 2005 concerned the supervision of the reasonableness of electricity distribution pricing. According to the newly adopted ex ante regulation principles, the regulatory authority now determines the guidelines for reasonable pricing prior the start of a predefined ...

Energy Technology Data Exchange (ETDEWEB)

The goal of this paper is to explore how compliance with the Clean Air Act Amendments of 1990 (CAAA), especially Title IV and emission trading under it, will affect the current relationship between state and federal regulation. It is difficult, with the limited experience we have had under Title IV, to be definitive about or to be a very strong advocate of too many policy positions. What may be most helpful at this point is to identify where the difficult issues in state/federal relations might arise; and then to explore ways in which tensions might be either avoided or resolved. One anticipated conclusion is that a traditional regulatory mindset could be very destructive if applied to this new area of oversight without due sensitivity to what Congress is trying to achieve in Title IV. That concern pervaded the early legislative debates; and it persists today. Title IV presents some unique challenges to state regulators and ...

Energy Technology Data Exchange (ETDEWEB)

Our inability to associate distant regulatory elements with the genes that they regulate has largely precluded their examination for sequence alterations contributing to human disease. One major obstacle is the large genomic space surrounding targeted genes in which such elements could potentially reside. In order to delineate gene regulatory boundaries we used whole-genome human-mouse-chicken (HMC) and human-mouse-frog (HMF) multiple alignments to compile conserved blocks of synteny (CBS), under the hypothesis that these blocks have been kept intact throughout evolution at least in part by the requirement of regulatory elements to stay linked to the genes that they regulate. A total of 2,116 and 1,942 CBS>200 kb were assembled for HMC and HMF respectively, encompassing 1.53 and 0.86 Gb of human sequence. To support the existence of complex long-range regulatory domains within these CBS we analyzed the prevalence and distribution of ...

International Nuclear Information System (INIS)

The licensing status and procedures, regulatory framework, and current safety issues of CANDU type reactors, Wolsong units 2, 3 and 4 are examined. Licensing difficulties and lessons learned during the safety review of Wolsong 2, 3 and 4 and future requirements are also summarized. The review was conducted, not only to confirm the design adequacy with respect to the domestic atomic laws and regulatory requirements of the vendor country, Canada, but also to reflect into the design the lessons learned from the regulatory experiences of operating Wolsong I to enhance the safety as high as practically possible. Safety issues observed during the licensing review, such as containment integrity, fuel channel integrity, etc., are summarized. Several efforts have been conducted to harmonize the Canadian regulations with the Korean ones by establishing domestic regulatory positions and guidelines. For example, the utility was requested to produce the ...

Energy Technology Data Exchange (ETDEWEB)

Accurate automated alignment of laser beams in the National Ignition Facility (NIF) is essential for achieving extreme temperature and pressure required for inertial confinement fusion. The alignment achieved by the integrated control systems relies on algorithms processing video images to determine the position of the laser beam images in real-time. Alignment images that exhibit wide variations in beam quality require a matched-filter algorithm for position detection. One challenge in designing a matched-filter based algorithm is to construct a filter template that is resilient to variations in imaging conditions while guaranteeing accurate position determination. A second challenge is to process the image as fast as possible. This paper describes the development of a new analytical template that captures key recurring features present in the beam image to accurately estimate the beam ...

Energy Technology Data Exchange (ETDEWEB)

The report presents a long-range plan for a broad-based, coordinated research, development and market transformation program for reducing the lighting energy intensities in commercial and residential buildings in California without compromising lighting quality. An effective program to advance lighting energy efficiency in California must be based on an understanding that lighting is a mature field and the lighting industry has developed many specialized products that meet a wide variety of light needs for different building types. Above all else, the lighting field is diverse and there are applications for a wide range of lighting products, systems, and strategies. Given the range of existing lighting solutions, an effective energy efficient lighting research portfolio must be broad-based and diverse to match the diversity of the lighting market itself. The belief that there is one solution--a magic bullet, such as a better lamp, for example--that will propel lighting efficiency ...

Energy Technology Data Exchange (ETDEWEB)

Photodestruction has received much attention in recent years. In particular, titanium dioxide (TiO{sub 2}) and ozonolysis have attained a position of prominence. These technologies hold promise for the destruction of trace amounts of aqueous high explosives that are generated by load and pack operations, as well as demilitarization activities. Currently this water is treated by passing through a bed of activated carbon. The carbon is then steam regenerated and reused, thus creating a second waste stream which must be disposed of, or the carbon is burned directly. Recent trends in environmental regulation have shown that this may not be a viable option for process water remediation in the future. This talk will discuss efforts to employ alternate aqueous treatment techniques that not only remove the explosives compounds but are able to transform the parent compound into carbon dioxide and water. Titanium dioxide photocatalysis as well as ...

British Library Electronic Table of Contents (United Kingdom)

Astrocytes have important immune functions in CNS, and astrocytes stimulated by interferon-g were showed to have direct antimicrobial function. However whether astrocytes without the stimulation of cytokines have antibacterial function, and how this function is regulated are still largely unknown. In this study, we found that primary cultured astrocytes inhibited the growth of both gram-negative and gram-positive bacteria. Further more, we showed that interleukin-1b (IL-1b) enhanced the antibacterial effect in a dose-dependent manner, and the antibacterial effect of astrocytes from IL-1b receptor-deficient mice failed to be enhanced by IL-1b. IL-1b stimulated IkBa degradation, NF-kB nuclear translocation, and transactivation in astrocytes. NF-kB inhibitors blocked NF-kB activation and the ...

Energy Technology Data Exchange (ETDEWEB)

The developed system is intended for use at a collimated thermal neutron beam with a flux of about 10{sup 6} n/cm{sup 2} s. The system works with a cooled CCD array (192 x 165 pixels) and an intensifier for light from a NE426 scintillator with traditional optical coupling. A fine mechanical regulation system allows an accurate positioning of the tomographer, also ensuring the alignment of the CCD array with the rotation and translation axes. The acquisition of 200 projections is carried out in about 30 min with a reconstruction time (40 min max) depending on the reconstruction-matrix order. Radiography and tomography of significant objects are illustrated. The reconstruction algorithm, including spatial and temporal inhomogeneity corrections and filters, was tested with good results for projections up to 512 x 512 pixels. (orig.)

Energy Technology Data Exchange (ETDEWEB)

A wind turbine is disclosed which permits high energy production over a wide range of wind forces while being protected against climatic hazards. According to the invention, a mast supports an energy recuperator comprising vane-type rotors by means of a frame which is orientable around a vertical axis. An energy conversion device is connected to the recuperator in order to be driven in rotation by the recuperator. The frame is responsive to the aerodynamic force exerted on the recuperator with respect to the mast and to the ground so as to optimize the power collected by the machine. The frame comprises a turret pivoted to the mast about the vertical axis and a structure pivoted to the turret about a horizontal axis of tilting motion. A balance weight maintains the recuperator in the top position when there is no wind. The aerodynamic drag of the recuperator acts in the opposite direction. In consequence, in the event of a high wind, the recuperator moves down ...

Energy Technology Data Exchange (ETDEWEB)

Increasingly stringent pollution regulations have spurred a broad interest in the reduction of engine emissions. Two strategies can be considered: after-treatment or engine emissions reduction. For Diesel engines, after-treatment has a high cost induced by the required technology and implementation issues. In this context, the Highly Premixed Combustion combustion mode (HP C) has emerged as a topic of major interest in recent years. It represents one of the most promising ways for new generation of CI engines using high Exhaust Gas Recirculation (EGR) rates. Experimentation on the test bench brought the proof of significant emission reduction. However, actual vehicle implementation implies frequent transient which fall far beyond steady state experimentation on the test bench. Several key challenges have to be addressed. With this combustion technology; accurate torque balancing at all engine modes is a requirement. Even slight unbalance ...

Energy Technology Data Exchange (ETDEWEB)

Biocatalytic Desulfurization (BDS) represents an alternative approach to the reduction of sulfur in fossil fuels. The objective is to use bacteria to selectively remove sulfur from petroleum and middle distillate fractions, without the concomitant release of carbon. Recently, bacteria have been developed which have the ability to desulfurize dibenzothiophene (DBT) and other organosulfur molecules. These bacteria are being developed for use in a biocatalyst-based desulfurization process. Analysis of preliminary conceptual engineering designs has shown that this process has the potential to complement conventional technology as a method to temper the sulfur levels in crude oil, or remove the recalcitrant sulfur in middle distillates to achieve the deep desulfurization mandated by State and Federal regulations. This paper describes the results of initial feasibility studies, sensitivity analyses and conceptual design work. Feasibility studies with various crude oils ...

Science.gov (United States)

... (tb*it 06(M WfIio[td) Page 2. Asynchronous Digital Regulators Vernon Scott Ritchey, Ph.D. ... Page 3. ASYNCHRONOUS DIGITAL REGULATORS ...

International Nuclear Information System (INIS)

The purpose of this paper is to evaluate a complete set of environmental pathways for disposal options and conditions that the Nuclear Regulatory Commission (NRC) may analyze for a low-level radioactive waste (LLW) license application. The regulations pertaining In the past, shallow-land burial has been used for the disposal of low-level radioactive waste. However, with the advent of the State Compact system of LLW disposal, many alternative technologies may be used. The alternative LLW disposal facilities include below- ground vault, tumulus, above-ground vault, shaft, and mine disposal This paper will form the foundation of an update of the previously developed Sandia National Laboratories (SNL)/NRC LLW performance assessment methodology. Based on the pathway assessment for alternative disposal methods, a determination will be made about whether the current methodology can satisfactorily analyze the pathways and phenomena likely to be important for the full range ...

Science.gov (United States)

In the Savannah River Site's (SRS') Solid Waste Management Program, a key to success is the Public Involvement Program. The Solid Waste Division at SRS manages the site's transuranic, low-level, mixed, and hazardous wastes. All decisions associated with management of this waste are of interest to the public and successful program implementation would be impossible without a vigorous public involvement program. The SRS Solid Waste Division (SWD) and its Department of Energy (DOE) customer developed, implemented, and maintain a comprehensive public participation and communications program. It is staffed by public participation and technical specialists to ensure information is presented in a manner that is technically accurate while being tailored for understanding by people without a technical background. The program provides the public with accurate, complete, timely information and early meaningful participation opportunities. It also ...

DEFF Research Database (Denmark)

Antisense- or RNAi-mediated suppression of the biosynthesis of nutritionally inferior storage proteins is a promising strategy for improving the amino acid profile of seeds. However, the potential pleiotropic effects of this on interconnected pathways and the agronomic quality traits need to be addressed. In the current study, a transcriptomic analysis of an antisense C-hordein line of barley was performed, using a grain-specific cDNA array. The C-hordein antisense line is characterized by marked changes in storage protein and amino acid profiles, while the seed weight is within the normal range and no external morphological irregularities were observed. The results of the transcriptome analysis showed excellent correlation with data on changes in the relative proportions of storage proteins and amino acid composition. The antisense line had a lower C-hordein level and down-regulated transcript encoding C-hordein. The production of the S-rich B/ - and D-hordeins ...

Science.gov (United States)

PMID:21765026

International Nuclear Information System (INIS)

The world's fleet of nuclear power plants is, on average, more than 20 years old. Even though the design life of a nuclear power plant is typically 30-40 years, it is quite feasible that many plants will be able to operate in excess of their design lives, provided that nuclear power plant engineers demonstrate by analysis, trending, equipment and system upgrades, increased vigilance, testing and ageing management that the plant will operate safely. In the operation of nuclear power plants, safety should be always the prime consideration. Plant operators and regulators must always ensure that plant safety is maintained, and where possible enhanced, during a plant's operating lifetime. Nuclear power plant life management (PLiM) has gained increased attention over the past decade, and effective ageing management of systems, structures and components (SSCs) is a key element in PLiM for the safe and reliable long term operation of nuclear power ...

Energy Technology Data Exchange (ETDEWEB)

Household demand for better environmental quality is the key factor in the long-term global applicability of the Environmental Kuznets Curve (EKC) hypothesis. We argue that, for given consumer preferences, the threshold income level at which the EKC turns downwards or the equilibrium income elasticity changes sign from positive to negative depends on the ability to spatially separate production and consumption. We test our hypothesis by estimating the equilibrium income elasticities of five pollutants, using 1990 data for the United States. We find that the change in sign occurs at lower income levels for pollutants for which spatial separation is relatively easy as compared to pollutants for which spatial separation is difficult. Our results suggest that even high-income households in the United States have not yet reached the income level at which their demand for better environmental quality is high enough to cause the income-pollution ...

Energy Technology Data Exchange (ETDEWEB)

This Progress Report describes the operation of the Los Alamos Meson Physics Facility (LAMPF) and the research programs carried out there for the years 1992 and 1993. The accelerator operated for over 100 days in 1992, providing beams of H{sup +}, H{sup {minus}}, and polarized H{sup {minus}} for a rich and varied research program in nuclear physics. The accelerator had only fair beam availability in 1992 (for example, the average H{sup +} beam availability was 72%), caused largely by problems in the 201-MHz rf system. A major effort was expended to address these problems before the 1993 run. These efforts were rewarded by good beam availability in 1993 and few problems with the 201-MHz system. LAMPF operated remarkably smoothly during 1993, in the midst of a period of great uncertainty in the future of the facility and the downsizing of MP Division, which led to the loss of a large number of key people to positions elsewhere in the Laboratory. ...

Energy Technology Data Exchange (ETDEWEB)

Multilayer mirror coatings which reflect extreme ultraviolet (EUV) radiation are a key enabling technology for EUV lithography. Mo/Si multilayers with reflectances of 67.5% at 13.4 nm are now routinely achieved and reflectances of 70 2% at 11.4 nm were obtained with MO/Be multilayers. High reflectance is achieved with careful control of substrate quality, layer thicknesses, multilayer materials, interface quality, and surface termination. Reflectance and film stress were found to be stable relative to the requirements for application to EUV lithography. The run-to-run reproducibility of the reflectance peak position was characterized to be better than 0.2%, providing the required wavelength matching among the seven multilayer-coated mirrors used in the present lithography system design. Uniformity of coating was improved to better than 0.5% across 150 mm diameter substrates. These improvements in EUV multilayer mirror technology will enable us ...

CERN Document Server

We explore a possibility that the daily sea-level pressure (SLP) over South Korea responds to the high-speed solar wind event. This is of interest in two aspects: First, if there is a statistical association this can be another piece of evidence showing that various meteorological observables indeed respond to variations in the interplanetary environment. Second, this can be a very crucial observational constraint since most models proposed so far are expected to preferentially work in higher latitude regions than the low latitude region studied here. We have examined daily solar wind speed ${\\rm V}$, daily SLP difference ${\\rm \\Delta SLP}$, and daily ${\\rm \\log(BV^{2})}$ using the superposed epoch analysis in which the key date is set such that the daily solar wind speed exceeds 800 ${\\rm kms^{-1}}$. We find that the daily ${\\rm \\Delta SLP}$ averaged out of 12 events reaches its peak at day +1 and gradually decreases back to its normal level. The amount of ...

CERN Document Server

In key management schemes that realize secure multicast communications encrypted by group keys on a public network, tree structures are often used to update the group keys efficiently. Selcuk and Sidhu have proposed an efficient scheme which updates dynamically the tree structures based on the withdrawal probabilities of members. In this paper, it is shown that Selcuk-Sidhu scheme is asymptotically optimal for the cost of withdrawal. Furthermore, a new key management scheme, which takes account of key update costs of joining in addition to withdrawal, is proposed. It is proved that the proposed scheme is also asymptotically optimal, and it is shown by simulation that it can attain good performance for nonasymptotic cases.

Energy Technology Data Exchange (ETDEWEB)

We developed prototype chemistry for nucleic acid hybridization on our bead-based diagnostics platform and we established an automatable bead handling protocol capable of 50 part-per-billion (ppb) sensitivity. We are working towards a platform capable of parallel, rapid (10 minute), raw sample testing for orthogonal (in this case nucleic acid and immunoassays) identification of biological (and other) threats in a single sensor microsystem. In this LDRD we developed the nucleic acid chemistry required for nucleic acid hybridization. Our goal is to place a non-cell associated RNA virus (Bovine Viral Diarrhea, BVD) on the beads for raw sample testing. This key pre-requisite to showing orthogonality (nucleic acid measurements can be performed in parallel with immunoassay measurements). Orthogonal detection dramatically reduces false positives. We chose BVD because our collaborators (UC-Davis) can supply samples from persistently infected animals; ...

Science.gov (United States)

In this study, the complete sequence of the mitochondrial DNA (mtDNA) of Atelura formicaria (Hexapoda: Zygentoma) is described. The molecule is 15.205 bp in length and it is the third complete mt genome sequenced from the Zygentoma. The genome organization conforms with the putative ancestral insect gene arrangement. All protein coding genes use standard initiation codons (methionine and isoleucine). The exception is nad4 that starts with GTG, a codon used for this purpose in other insect species. A peculiar strand skew bias is observed, given that the PCGs encoded on the J-strand contain more thymines than adenines and more cytosines than guanines. This trend in nucleotide composition has been observed also in the "firebrat" Thermobia domestica (Zygentoma, Lepismatidae), but differs from that of the majority of hexapod species, including Tricholepidion gertschi (Zygentoma, Lepidotrichidae), where adenines and cytosines outnumber thymines and guanines. The presence of structural ...

British Library Electronic Table of Contents (United Kingdom)

Abstract MicroRNAs (miRNAs) play important roles in global gene regulation. Researchers in recombinant protein production have proposed miRNAs as biomarkers and cell engineering targets. However, miRNA expression remains understudied in Chinese Hamster Ovary cells, one of the most commonly used host cell systems for therapeutic protein production. To profile highly conserved miRNA expression, we used the miRCURY- miRNA array for screening miRNAs in CHO cells. The selection criteria for further miRNA profiling included positive hybridization signals and experimentally validated predicted regulatory targets. On the basis of screening, we selected 16 miRNAs for quantitative RT-PCR profiling. We profiled miR expression in parental CHO DG44 and CHO K1 cell lines as well as four recombinant DG44...

Energy Technology Data Exchange (ETDEWEB)

The demonstration test of a power system stabilizer, employing a fuzzy theory, in the two hydroelectric power stations of Kyusyu Electric Power Co., Inc. is described. The PSS inputs auxiliary signals to the automatic voltage regulator (AVR) of a generator and generates an electric torque in the direction opposite to the operating direction of a generator to enhance the damping effect and improve the system stability. Usually, the change in the slide information of a generator is detected, and the phase adjustment is performed so that the damping is the optimum value. However, since the damping is optimized in the specific system state, no complete damping may be obtained when the system state is changed. A fuzzy theory was thus applied for the control operation part. In a secondary fuzzy PSS, the velocity and acceleration were calculated from the slide information of a generator to produce a control signal. In the third dimension, moreover, the ...

Science.gov (United States)

The gene expression of beta(1)-adrenergic receptor (beta(1)AR) and stimulatory G-protein Gsalpha in ventricle after chronic treatment with doxorubicin (DOX) in rat was investigated. The rats were treated with DOX in a dose of 2.5 mg/kg once a week for 5 weeks, the cumulative dose being 12.5 mg/kg. Two weeks after the last injection, the positive inotropic effect of isoproterenol was noticeably decreased in left atrial muscle preparations isolated from DOX-treated rats. Northern blot hybridization showed that the mRNA transcripts of beta(1)AR and Gsalpha, important signal transduction elements for regulating heart rate and contractility, were significantly decreased in the ventricle of DOX-treated rats. Thus, chronic treatment with DOX decreases the gene expression levels of myocardial beta(1)AR and Gsalpha. PMID:15353854

Science.gov (United States)

We have constructed a 27-kDa hTERT C-terminal polypeptide (hTERTC27) devoid of domains required for telomerase activity and demonstrated that it is capable of nuclear translocation/telomere-end targeting. Here we showed that expression of a low level of hTERTC27 renders hTERT positive HeLa cells sensitive to H(2)O(2)-induced oxidative stress and subsequent cell senescence. The senescence-associated gene, the cyclin/cdk inhibitor p21(Waf1), was up-regulated. This occurs without changing the expression of endogenous hTERT, causing significant telomere shortening or inhibiting telomerase activity. Results from this study suggest for the first time that in addition to telomerase activity, the C-terminus of hTERT also plays a role in hTERT-mediated cellular resistance to oxidative stress. PMID:12565825

ScienceCinema

...english uh ? that's quite motor ...

Energy Technology Data Exchange (ETDEWEB)

A cytochrome P450 that hydroxylates lauric acid at the 12 position (P450LA omega) was isolated from liver microsomes of clofibrate treated rats. P450LA omega was immunologically distinct from P450s a,b,c,d,e,f,g,h,j,PB1, and PCN1. Polyclonal antibody against P450LA omega was utilized to screen a gt11 cDNA library. A clone (pP450LA omega), was isolated and its sequence determined. The P450LA omega mRNA is a minimum 2387 nts in length and codes for a P450 of Mr.58,222 daltons. This protein shares less than 35% amino acid similarity with P450s b,c,d,e,f,PB1, and PCN1; however, it does contain a hydrophobic amino terminal peptide and a conserved sequence surrounding the Cys residue at position 456, which is similar to other microsomal P450s. P450LA omega is present at high levels in untreated rat kidney and is induced by clofibrate in both kidney and liver. This induction is the result of an accumulation of mRNA through a rapid transcriptional ...

UK PubMed Central (United Kingdom)

MicroRNAs (miRs) can regulate many cellular functions, but their roles in regulating responses of vascular endothelial cells (ECs) to mechanical stimuli remain unexplored. We hypothesize that the physiological...Full Text Available

UK PubMed Central (United Kingdom)

Hyaluronan (HA) is important for joint cavitation, lubrication, volume regulation and synovial fluid drainage but little is known about the regulation of joint HA synthesis/secretion in vivo....Full Text Available

UK PubMed Central (United Kingdom)

Cytokine regulation of synovial fluid (SF) lubricants, hyaluronan (HA), and proteoglycan 4 (PRG4) is important in health, injury, and disease of synovial joints, and may also provide powerful regulation...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundHuman Papillomavirus (HPV) E2 plays several important roles in the viral cycle, including the transcriptional regulation of the oncogenes E6 and E7, the regulation of the...Full Text Available

Science.gov (United States)

...Acquisition Regulations System 3 2010-10-01...Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF...assumption of risk for transportation by conveyance on...Missiles, and Space Launch Vehicles,...

UK PubMed Central (United Kingdom)

We report the identification and characterization of a new Drosophila clock-regulated gene, takeout (to). to is a member of a novel...Full Text Available

UK PubMed Central (United Kingdom)

The growth and development of rice (Oryzae sativa) seedlings was shown to be regulated epigenetically by a fungal endophyte. In contrast to un-inoculated (nonsymbiotic) plants, endophyte...Full Text Available

Science.gov (United States)

Federal regulators were set to vote on a plan to protect deep water corals and other sensitive fish habitats that will likely include a permanent ban on ...

UK PubMed Central (United Kingdom)

The regulation of the glutamate dehydrogenases was investigated in wild-type Neurospora crassa and two classes of mutants altered in the assimilation of inorganic nitrogen, as either...Full Text Available

UK PubMed Central (United Kingdom)

The regulation of blood vessel formation is of fundamental importance to many physiological processes, and angiogenesis is a major area for novel therapeutic approaches to diseases from ischemia to...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The Eiric Raude offshore drilling rig is a powerful machine that is suitable for drilling in harsh environments in ultra deep water. It has a total drilling depth of 8,200 to 10,000 metres and an operational displacement of 53,400 mt. The rig complies with the regulatory regimes of Norway, the United Kingdom and Canada. The Eiric Raude has drilled 5 deepwater wells offshore eastern Canada, 1 well offshore Cuba, 1 well west of Shetland, and 3 offshore Norway. The environmental criteria for extreme weather conditions consider wave, current and wind forces. The general operational guidelines were discussed along with key areas for prevention of environmental impact, including emissions from well testing, air emissions from diesel engines, cooling water, bunkering operations, discharges from drilling, accidental discharges, drain water, and domestic sewage. It was noted that the zero discharge philosophy is the basis for all activities. The original design was meant to ...

Science.gov (United States)

Abstract High-mobility group box 1 (HMGB1), a damage-associated molecular pattern (DAMP) molecules, favors tissue regeneration via recruitment and activation of leukocytes and stem cells. Here we demonstrate, in a model of acute sterile muscle injury, that regeneration is accompanied by active reactive oxygen species (ROS) production counterbalanced and overcome by the generation of antioxidant moieties. Mitochondria are initially responsible for ROS formation. However, they undergo rapid disruption with almost complete disappearance. Twenty-four hours after injury, we observed a strong induction of MURF1 and atrogin-1 ubiquitin ligases, key signals in activation of the proteasome system and induction of muscle atrophy. At later time points, ROS generation is maintained by nonmitochondrial sources. The antioxidant response occurs in both regenerating fibers and leukocytes that express high levels of free thiols and antioxidant enzymes, such as superoxide dismutase ...

Science.gov (United States)

The kinetics of benzoate degradation by the anaerobic syntrophic bacterium, Syntrophus buswellii, was studied in coculture with Desulfovibrio strain G11. The threshold value for benzoate degradation was dependent on the acetate concentration with benzoate threshold values ranging from 2.4 [mu]M at 20 mM acetate to 30.0 [mu]M at 65 mM acetate. Increasing acetate concentrations also inhibited the rate of benzoate degradation with a apparent K[sub i] for acetate inhibition of 7.0 mM. Lower threshold values were obtained when nitrate rather than sulfate was the terminal electron acceptor. These data are consistent with a thermodynamic explanation for the threshold, and suggest that there is a minimum Gibbs free energy value required for the degradation of benzoate. An acetoacetyl-CoA thiolase has been isolated from Syntrophomonas wolfei; it is apparently a key enzyme controlling the synthesis of poly-B-hydroxyalkanoate from acetyl-CoA in this organism. Kinetic ...

Energy Technology Data Exchange (ETDEWEB)

The PIUS reactor utilizes simplified, inherent, passive, or other innovative means to accomplish safety functions. Accordingly, the PIUS reactor is subject to the requirements of 10CFR52.47(b)(2)(i)(A). This regulation requires that the applicant adequately demonstrate the performance of each safety feature, interdependent effects among the safety features, and a sufficient data base on the safety features of the design to assess the analytical tools used for safety analysis. Los Alamos has assessed the quality and completeness of the existing and planned data bases used by Asea Brown Boveri to validate its safety analysis codes and other relevant data bases. Only a limited data base of separate effect and integral tests exist at present. This data base is not adequate to fulfill the requirements of 10CFR52.47(b)(2)(i)(A). Asea Brown Boveri has stated that it plans to conduct more separate effect and integral test programs. If appropriately designed and conducted, ...

British Library Electronic Table of Contents (United Kingdom)

For companies, relationships with external actors may constitute intangible assets. Many firms have put in place key account management programs in order to pay sufficient attention to strategically important customers and the marketing literature has studied such programs. However, a company's relationship portfolio also comprises relationships with other types of actors. The objective of this paper is to show that ? across the different types of external relationships a company may develop ? some relationships have more importance than others and, hence, are key. The authors argue that, as a consequence, the keyness of certain relationships has led to the emergence of approaches which can be referred to as key relationship management. For this purpose, the authors first present empirical...

KoreaScience (Korea)

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CERN Document Server

Nuclear plants decommissioning

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Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

UK PubMed Central (United Kingdom)

AbstractIndividual informed consent is a key ethical obligation for clinical studies, but empirical studies show that key requirements are often not met. Common recommendations to strengthen...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

After an international ideas competition by TNC Switzerland and Germany in 1996, six companies where given the opportunity to construct a prototype of their newly developed integrated PV-sound barrier concepts. The main goal was to develop highly integrated concepts, allowing the reduction of PV sound barrier systems costs, as well as the demonstration of specific concepts for different noise situations. This project is strongly correlated with a German project. Three of the concepts of the competition are demonstrated along a highway near Munich, constructed in 1997. The three Swiss installations had to be constructed at different locations, reflecting three typical situations for sound barriers. The first Swiss installation was the world first Bi-facial PV-sound barrier. It was built on a highway bridge at Wallisellen-Aubrugg in 1997. The operational experience of the installation is positive. But due to the different efficiencies of the two cell sides, its ...

Energy Technology Data Exchange (ETDEWEB)

The minimization of the environmental footprint is the underlying principle of companies involved in sustainable development. At the same time, those companies seek to contribute to the economic and social development of the communities in which they have a presence. The evidence linking sustainable development and value creation are examined in this report targeted to the investment community, which is part of an overall leadership initiative undertaken by the Conference Board of Canada. The benchmarks of companies committed to sustainable development have, on the whole, been matched or exceeded, as shown by recent evidence based on the performance of seven prominent funds and indices managed in Canada, the United States, and western Europe. They are: the Domini Social Equity Fund (American focus), the EcoValue 21{sup TM} (American focus), the Dow Jones Sustainability Group Index (international focus), Storebrand Scudder Environmental Value Fund (European focus), the Jantzi Social ...

International Nuclear Information System (INIS)

A real-time neutron radiography imaging system has been installed at the Texas A and M University Nuclear Science Center. The system employs a scintillating screen viewed by a low-light TV camera with a front surface mirror placed at 45deg to the neutron beam. The key components of the system are the neutron camera and the image capture and processing unit. The neutron camera uses an NE 426 scintillating screen (ZnS), front surface mirror, remote focus and zoom lens, intensified relay optics (IRO) and monochrome CCD television camera. The image capture and processing unit consists of an IBM PC AT-compatible computer, arithmetic frame grabber, frame processor and high-resolution color monitor. The neutron camera is similar to others using a silicon intensified target (SIT) television camera to provide a TV image of the low-level light from a NE 426 screen. The IRO and CCD camera are used in place of the SIT camera. The computer digitizes the TV image (512x512x8 bit) ...

International Nuclear Information System (INIS)

The helium-cooled HTGR (High Temperature Gas-cooled Reactor) will take an important position in the global energy strategy. It is expected to supply not only electricity but also high quality thermal energy for various industries and local utilities without exhausting any green house effect gas or acid rain gas. The key R and D issue of the HTGR is economical competitiveness, particularly against light water reactors. Due to the poor heat transfer of the single phase helium, the HTGR's volumetric power density is restricted to tenth of corresponding PWR's value so that increasing the power density by improving heat transfer is strongly desired. The standstill can be broken through by adopting gas-solid suspension medium. Its heat transfer performance is quite excellent. Its heat capacity can be increased drastically without excessive pressurization. Although the thermal radiation is a dominant heat transfer mode in high temperature region, the ...

International Nuclear Information System (INIS)

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has two major functions: interacting with the receptor to mediate virus entry and inducing protective immunity. Coincidently, the receptor-binding domain (RBD, residues 318-510) of SAR-CoV S protein is a major antigenic site to induce neutralizing antibodies. Here, we used RBD-Fc, a fusion protein containing the RBD and human IgG1 Fc, as a model in the studies and found that a single amino acid substitution in the RBD (R441A) could abolish the immunogenicity of RBD to induce neutralizing antibodies in immunized mice and rabbits. With a panel of anti-RBD mAbs as probes, we observed that R441A substitution was able to disrupt the majority of neutralizing epitopes in the RBD, suggesting that this residue is critical for the antigenic structure responsible for inducing protective immune responses. We also demonstrated that the RBD-Fc bearing R441A mutation could not bind to soluble and cell-associated ...

Energy Technology Data Exchange (ETDEWEB)

The objective of project is to derive the policy recommendations to improve the efficiency of CANDU plants regulation. These policy recommendations will eventually contribute to the upgrading of Korean nuclear regulatory system and safety enhancement. During the second phase of this 2 years study, following research activities were done. Review the technical basis and framework of the new Canadian Regulation System and IAEA. Analysis on the interview of Wolsung operation staffs to identify important safety issues and regulation problems experienced at operation. Providing a plan of CANDU regulation system enhancement program.

Science.gov (United States)

... Uninterrupted access to and use of critical infrastructure in the Arabian Gulf region are key to the successful prosecution of the Global War on Terror ...

Science.gov (United States)

We report a search for small RNAs (sRNAs) in the low-GC, gram-positive human pathogen Streptococcus pneumoniae. Based on bioinformatic analyses by Livny et al. (J. Livny, A. Brencic, S. Lory, and M. K. Waldor, Nucleic Acids Res. 34:3484-3493, 2006), we tested 40 candidates by Northern blotting and confirmed the expression of nine new and one previously reported (CcnA) sRNAs in strain D39. CcnA is one of five redundant sRNAs reported by Halfmann et al. (A. Halfmann, M. Kovacs, R. Hakenbeck, and R. Bruckner, Mol. Microbiol. 66:110-126, 2007) that are positively controlled by the CiaR response regulator. We characterized 3 of these 14 sRNAs: Spd-sr17 (144 nucleotides [nt]; decreased in stationary phase), Spd-sr37 (80 nt; strongly expressed in all growth phases), and CcnA (93 nt; induced by competence stimulatory peptide). Spd-sr17 and CcnA likely fold into structures containing single-stranded regions between hairpin ...

Energy Technology Data Exchange (ETDEWEB)

The goal of this study is to estimate the relevance and Influence of the Existing Regulation and the RI-PBR to the institutionalization of the regulatory system. This study reviews the current regulatory system and the status of the RI-PBR implementation of the US NRC and Korea based upon SECY Papers, Risk Informed Regulation Implementation Plan (RIRIP) of the US NRC and other domestic studies. In order to investigate the perceptions, knowledge level, ground for the regulatory change, a survey was performed to Korean nuclear utilities, researchers and regulators on the perception on the RIR. The questionnaire was composed of 50 questions regarding personal details on work experience, level of education and specific field of work ; level of knowledge on the risk informed performance based regulation (RI-PBR); the perception of the current regulation, the effectiveness, level of ...

Energy Technology Data Exchange (ETDEWEB)

When preadipocytes differentiate into adipocytes, several differentiation-linked genes are activated. Lipo-protein lipase (LPL) is one of the first genes induced during this process. To investigate early events in adipocyte development, we have focused on the transcriptional activation of the LPL gene. For this purpose, we have cloned and fused different parts of intragenic and flanking sequences with a chloramphenicol acetyltransferase reporter gene. Transient transfection experiments and DNase I hypersensitivity assays indicate that several positive as well as negative elements contribute to transcriptional regulation of the LPL gene. When reporter gene constructs were stably introduced into preadipocytes, we were able to monitor and compare the activation patterns of different promoter deletion mutants at selected time points representing the process of adipocyte development. We could delimit two cis-regulatory elements important for gradual ...

UK PubMed Central (United Kingdom)

IntroductionApproximately 25–30% of breast cancers are assumed to be HER-2/neu positive. It is well known that HER-2/neu-positive cancers after treatment with trastuzumab...Full Text Available

International Nuclear Information System (INIS)

The primary UK legislation relating to the use of radioactive materials are the Radioactive Substances Act 1993 (RSA, 1993) and the Ionising Radiations Regulations 1999 (IRR, 1999). These implement the European Union's Basic Safety Standards Directive (EUBSS) (EC, 1996). The Radioactive Substances Act 1993 (RSA93) regulates the accumulation, storage and disposal of radioactive waste, principally to control potential doses to members of the public. The Ionising Radiations Regulations 1999 (IRR, 1999) deal primarily with regulating the doses that people receive at work. Both of these pieces of legislation apply to the use of materials containing naturally occurring radionuclides. Historically UK regulations relating to radioactive materials have covered both artificial and natural radionuclides

British Library Electronic Table of Contents (United Kingdom)

Philosophical semantics requires an ontology that includes negative as well as positive states of affairs as truth-makers and truth-breakers. Theories that try to do without negative states of affairs while interpreting propositional truth as positive correspondence with existent states of affairs are inherently inadequate and incomplete. A semantics and ontology of negative states of affairs can also do justice to positive states of affairs, since the iterated negative state of affairs that a negative state of affairs exists describes a positive state of affairs, but the iterated positive state of affairs that a positive state of affairs exists never describes a negative state of affairs. Negative states of affairs are not only essential to semantics, but to a complete description of the ...

UK PubMed Central (United Kingdom)

The central nervous system regulates peripheral immune responses via the vagus nerve, the primary neural component of the cholinergic anti-inflammatory pathway. Electrical stimulation of the...Full Text Available

UK PubMed Central (United Kingdom)

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover,...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNFκB signaling is of paramount importance in the regulation of apoptosis, proliferation, and inflammatory responses during human development and homeostasis, as...Full Text Available

UK PubMed Central (United Kingdom)

SummaryThe Hippo tumor-suppressor pathway controls tissue growth in Drosophila and mammals by regulating cell proliferation and apoptosis. The Hippo pathway includes...Full Text Available

UK PubMed Central (United Kingdom)

In many dinoflagellate species, the plastid genome has been proposed to exist as a limited number of single-gene minicircles, and many genes normally found in the plastid genome are nuclear-encoded....Full Text Available

UK PubMed Central (United Kingdom)

• Background and Aims Development and architecture of plant roots are regulated by phytohormones. Cytokinin (CK), synthesized in the root cap, promotes cytokinesis, vascular...Full Text Available

UK PubMed Central (United Kingdom)

For proper tissue morphogenesis, cell divisions and cell fate decisions must be tightly and coordinately regulated. One elegant way to accomplish this is to couple them with asymmetric cell divisions....Full Text Available

UK PubMed Central (United Kingdom)

The Neurofibromatosis-2 (NF2) tumor suppressor merlin negatively regulates cell proliferation in numerous cell types. We have previously shown that the NF2...Full Text Available

UK PubMed Central (United Kingdom)

Menin, which is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor and transcriptional regulator. Menin controls proliferation and apoptosis of cells, especially pancreatic...Full Text Available

UK PubMed Central (United Kingdom)

Noncoding RNAs play important roles in various aspects of gene regulation. We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGCs), a subnuclear domain...Full Text Available

UK PubMed Central (United Kingdom)

de Vito, Peter C. (Princeton University, Princeton, N.J.), and Jacques Dreyfuss. Metabolic regulation of adenosine triphosphate sulfurylase in yeast. J. Bacteriol. 88:1341–1348....Full Text Available

UK PubMed Central (United Kingdom)

The cytokine interleukin-7 (IL-7) has essential growth activities that maintain the homeostatic balance of the immune system. Little is known of the mechanism by which IL-7 signaling regulates metabolic...Full Text Available

UK PubMed Central (United Kingdom)

This paper describes a new technique that can be used to study chloroplast volume regulation in vivo. Nuclear magnetic resonance spectroscopy was used to measure relative amounts of chloroplast water...Full Text Available

UK PubMed Central (United Kingdom)

Keap1 regulates Nrf2 activity in response to xenobiotic and oxidative stresses. Nrf2 is an essential regulator of cytoprotective genes. Keap1-null mice are lethal by weaning age due...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The object of this Regulation is to provide for those matters that may be, or that are required to be, the subject of regulations under the Explosives Act 2003, The Regulation deals with the following maters: a) a register of authorised and prohibited explosives (Part. 2), b) the classification of explosives (Part. 3), c) matters related to licences under the Explosives Act 2003, including the types of licences, requirements for obtaining licences, certain prescribed licence conditions and certain exemptions from the requirement to have a licences (Part. 4), d) specific control measures relating to the handling of explosives (Part. 5), e) matters of a savings, transitional or administrative nature (Part. 1 and 6). This Regulation refers to the following documents: a) AS 2187, Explosives-storage, transport and use, as published by Standards Australia and in force from time to time, b) the Australian Code ...

UK PubMed Central (United Kingdom)

Ethylene rapidly and transiently up-regulates the activity of several monomeric GTP-binding proteins (monomeric G proteins) in leaves of Arabidopsis as determined by two-dimensional gel electrophoresis...Full Text Available

Science.gov (United States)

In this paper two different models of brain regulation of exercise performance are critically compared: the central governor model proposed by Noakes and colleagues, and an alternative psycholobiological model based on motivational intensity theory. PMID:18618133

UK PubMed Central (United Kingdom)

Normal reproductive functioning may require secretion of LH independently of FSH. Variation in GnRH pulse frequency and inhibin negative feedback are mechanisms for differential gonadotropin regulation;...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

These regulations establish procedures for the administration of the Privacy Act of 1974 by the Department of Energy (DOE). Included are standards of conduct for DOE employees under the Privacy Act, procedures by which individuals may exercise their Privacy Act rights with regard to DOE systems of records, conditions of disclosure for DOE records subject to the Privacy Act, and provisions regarding the establishment and maintenance of DOE systems of records. These regulations were published in proposed form on May 27, 1980, at 45 FR35764. A detailed discussion of the content and provisions of the regulations, as well as the relationship of the regulations to the Privacy Act regulations of DOE's predecessor agencies (the Federal Energy Administration, the Energy Research and Development Administration, and the Federal Power Commission), was included in the preamble to the ...

UK PubMed Central (United Kingdom)

Qualitative and quantitative aspects of the mechanisms involved in the regulation of cytoplasmic pH during an acid-load have been studied in Acer pseudoplatanus cells. Two main processes,...Full Text Available

UK PubMed Central (United Kingdom)

Histone Arg methylation and Lys acetylation have been found to cooperatively regulate the expression of p53 target genes. Peptidylarginine deiminase 4 (PAD4) is an enzyme that citrullinates...Full Text Available

UK PubMed Central (United Kingdom)

The regulation of gene expression in the brain reward regions is known to contribute to the pathogenesis and persistence of drug addiction. Increasing evidence suggests that the regulation of gene transcription...Full Text Available

UK PubMed Central (United Kingdom)

The protein kinase CK2 (formerly casein kinase II) is thought to be involved in light-regulated gene expression in plants because...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as...Full Text Available

UK PubMed Central (United Kingdom)

The ventromedial hypothalamus (VMH) plays a central role in the regulation of the female reproductive behavior lordosis, a behavior dependent upon the sequential activation of receptors for the ovarian...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation...Full Text Available

KoreaScience (Korea)

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Wastenet

to set in place regulations and processes to manage river basins based upon the ecological (and hydro-morphological) health

International Nuclear Information System (INIS)

English 2005 p. 52-59 International Atomic Energy Agency (IAEA) Collier,

British Library Electronic Table of Contents (United Kingdom)

The central nervous system (CNS), generally accepted to regulate energy homeostasis, has been implicated in the metabolic perturbations that either cause or are associated with obesity. Normally, the CNS receives hormonal, metabolic, and neuronal input to assure adequate energy levels and maintain stable energy homeostasis. Recent evidence also supports that the CNS uses these same inputs to regulate glucose homeostasis and this aspect of CNS regulation also becomes impaired in the face of dietary-induced obesity. This review focuses on the literature surrounding hypothalamic regulation of energy and glucose homeostasis and discusses how dysregulation of this system may contribute to obesity and T2DM.

KoreaScience (Korea)

Full Text Available

DEFF Research Database (Denmark)

Udgivelsesdato: March

Science.gov (United States)

As both computer and mobile phone reach nearly ubiquity in the U.S. market, the slow uptake of mobile video, in contrast to the thriving usage of PC-based video, warrants a deeper understanding of user-oriented factors contributing to the two diffusion paths. Unlike the majority of existing diffusion research practices, the dissertation examines the differences between mobile and PC video diffusion patterns through the lenses of user-oriented influences in the user-technology relationship. Built upon the established adoption user group classification, the research is informed by the Uses and Gratification theory, the Social Technical theory, and the Technical Affordance perspective. These synergistic theoretical arguments share the recognition of the role of user in the dynamic, usually socially intertwined user-technology interactions. The key research questions that the dissertation sets out to answer include: Does the importance of quality of viewing ...

Energy Technology Data Exchange (ETDEWEB)

In this study, for the institutionalization of risk informed and performance based regulation in Korea, the latest technical movements of overseas countries are examined and reviewed. And the issues that was found when license change petition using risk information was submitted in Korean regulatory body are reviewed. Based on these review, the applicable areas to domestic situation will be found and proposed. This study can contribute to setting up the proper direction for the institutionalization of risk informed and performance based regulation.

Energy Technology Data Exchange (ETDEWEB)

While hydropower industry finds great profit opportunities in increased effective production, the host municipals have anxiety for great environmental damages. Regulations of water reservoirs. Differences between highest and lowest planned water level are specified in regulations for water reservoirs. The background for these regulations are both esthetic and environmental. (AG)

Science.gov (United States)

PMID:17276750

Norwegian Open Research Archives (NORA)

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Science.gov (United States)

PMID:19939965

KoreaScience (Korea)

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Science.gov (United States)

Using an expanded nuclear data base, the transmutation of PCA, AMCR33 (a reduced activation austenitic steel), HT-9, Rafer2 (a reduced activation ferritic steel), V-15%Cr-5%Ti alloy, and SiAlON (a ceramic) were calculated for two positions in the Fast Flux Test Facility (FFTF), three positions in the High Flux Isotope Reactor (HFIR), and the first wall position of both the STARFIRE and MARS conceptual fusion reactors. The peripheral test (PTP) position, and to a lesser extent the radial beryllium (RB) position, of HFIR show significant transmutations which are often in the opposite direction to the transmutations in the fusion conceptual designs. The positions in FFTF, as well as the hafnium covered location in the HFIR RB position show relative minor transmutations.

Energy Technology Data Exchange (ETDEWEB)

We prove that the 1984 protocol of Bennett and Brassard (BB84) for quantum key distribution is secure. We first give a key distribution protocol based on entanglement purification, which can be proven secure using methods from Lo and Chau's proof of security for a similar protocol. We then show that the security of this protocol implies the security of BB84. The entanglement purification based protocol uses Calderbank-Shor-Steane codes, and properties of these codes are used to remove the use of quantum computation from the Lo-Chau protocol. (c) 2000 The American Physical Society.

International Nuclear Information System (INIS)

A key comparison has been made between the air-kerma standards of the ARPANSA and the BIPM in the low-energy X-ray range. The results show the standards to be in agreement at the level of the combined standard uncertainty of 7.0 parts in 10"3 for the 10 kV radiation quality and 3.7 parts in 10"3 for all other beam qualities. The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database. (authors)

British Library Electronic Table of Contents (United Kingdom)

C-type natriuretic peptide (CNP) is a member of the small family of natriuretic peptides that also includes atrial natriuretic peptide (ANP) and brain, or B-type natriuretic peptide (BNP). Unlike them, it performs its major functions in an autocrine or paracrine manner. Those functions, mediated through binding to the membrane guanylyl cyclase natriuretic peptide receptor B (NPR-B), or by signaling through the non-enzyme natriuretic peptide receptor C (NPR-C), include the regulation of endochondral ossification, reproduction, nervous system development, and the maintenance of cardiovascular health. To date, the regulation of CNP gene expression has not received the attention that has been paid to regulation of the ANP and BNP genes. CNP expression in vitro is regulated by TGF-b and recepto...

British Library Electronic Table of Contents (United Kingdom)

Erythroid differentiation regulator (Erdr1) was first discovered in mouse leukemia cell lines and functions as a stress-related survival factor. This study investigated whether Erdr1 regulates murine melanoma progression, as well as the mechanism involved in Erdr1-regulated metastasis. The expression of Erdr1 is negatively correlated with IL-18 expression, which has a pro-cancer effect in melanoma. To study the role of Erdr1 as an anti-cancer factor, cell migration, invasion, and proliferation were measured. Erdr1 overexpression markedly inhibited the level of cell migration, invasion, and proliferation in B16F10 cells in vitro. In addition, Erdr1 overexpression significantly suppressed melanoma lung colonization, metastasis, and tumor growth in vivo. To identify the factors involved in Er...

Science.gov (United States)

although additional research is needed to corroborate such findings. Key words: Avicennia germinans; disturbance; downed wood; Everglades National Park; Hurricane Andrew;...

British Library Electronic Table of Contents (United Kingdom)

Medical Science Liaison (MSL) teams are a well-recognized function within the pharmaceutical and medical products industries. While in most organizations, MSLs have focused on the development of relationships with individual Key Opinion Leaders, progressive companies have realized the value that MSLs can also bring to Key Account Management (KAM). This article discusses the five steps that should be followed in order to successfully integrate the support of Key Accounts into an MSL function. These include understanding the business approach to KAM, identifying what MSL resources are available, developing a comprehensive strategic plan, implementing the plan, and evaluating and making any necessary adjustments. Finally, a case example outlining the experience of a small pharmaceutical compa...

Energy Technology Data Exchange (ETDEWEB)

Summary brochure of GeoPowering the West (GPW) activities, and areas of technology transfer and market transformation. It also provides current contact information for key DOE and national laboratory staff representing the GPW program.

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Medline Plus

... very difficult to help get better and to rehabilitate and sometimes even need surgery. 00:04:21 ... step of treatment, from our standpoint, is to rehabilitate, to strengthen the shoulder. And the real key ...

International Nuclear Information System (INIS)

Since its creation the nuclear industry has been struggling with the question of how safe is safe enough. Safety is a common goal to all involved in the design, operation and regulation of a nuclear installation. As a concept safety is not easy to define. However, there is a general understanding of what attributes a nuclear power plant should have in order to operate safely. The challenge lies in measuring the attributes. The new competitive open electricity market, in many countries throughout the world, is increasing the economic pressure on operators to lower operating costs without jeopardizing safety. Challenges are occurring at a rate that is unprecedented in the nuclear industry: competitiveness; downsizing; ageing; policy changes; reorganization; restructuring; mergers; globalization; and takeovers demand increasing attention to the management of safety. There are various means to measure safety performance, some of which are more qualitative in nature and ...

Energy Technology Data Exchange (ETDEWEB)

Recycling and disposal of spent sodium-sulfur (Na/S) batteries are important issues that must be addressed as part of the commercialization process of Na/S battery-powered electric vehicles. The use of Na/S batteries in electric vehicles will result in significant environmental benefits, and the disposal of spent batteries should not detract from those benefits. In the United States, waste disposal is regulated under the Resource Conservation and Recovery Act (RCRA). Understanding these regulations will help in selecting recycling and disposal processes for Na/S batteries that are environmentally acceptable and cost effective. Treatment processes for spent Na/S battery wastes are in the beginning stages of development, so a final evaluation of the impact of RCRA regulations on these treatment processes is not possible. The objectives of tills report on battery recycling and disposal are as follows: Provide an overview of ...

Wastenet

...Keeping chickens: a beginner's guide : Directgov - Environment and greener living chickens, feeding chickens, egg marking, registering a ...flock, battery hens Chickens; Department for Environment, Food and Rural Affairs; Registrations; Animals; Livestock; Local government; Local ...authorities A guide for people keeping chickens on the laws for registering and feeding them, and how to spot key diseases. A ...guide for people keeping chickens on the laws for registering and feeding them, and how to spot key diseases. Keeping chickens: ...

International Nuclear Information System (INIS)

This guide explained the requirements for Off-Road Compression Ignition Engine Emission Regulations established under the Canadian Environmental Protection Act. The regulations are enforced by Environment Canada, which authorizes and monitors the use of the national emissions mark. The regulations prescribe standards for off-road engines that operate as reciprocating, internal combustion engines, other than those that operate under characteristics similar to the Otto combustion cycle and that use a spark plug or other sparking device. The regulations apply to engines that are typically diesel-fuelled and found in construction, mining, farming and forestry machines such as tractors, excavators and log skidders. Four different types of persons are potentially affected by the regulations: Canadian engine manufacturers; distributors of Canadian engines or machines containing Canadian ...

Energy Technology Data Exchange (ETDEWEB)

Since 1995, OECD started to examine the current situation of government regulation in each member country and discussed to recommend quality improvement of regulation to member countries. The conference on reformation of regulation in power industry was held in October and December 1998. In USA, enhancing competition in supplying electricity was recommended by eliminating differentiation in use of power network, transmission network and incidental facilities. The retail competition is also an important reformation. The reformation in Netherlands can be seen as following EU guide for revealing problems of the existing regulation in the power industry and for opening up a power market. The Dutch government passed the power act for opening up a market to the public between 1999 and 2007. In Japan, the entry of independent power provider (IPP) has been softened. With the opening of bid system in 1999, bids ...

Energy Technology Data Exchange (ETDEWEB)

Drastic changes in waste management procedures are expected from the German Municipal Waste Disposal Regulations which became effective on June 1, 1993. Waste disposal will be subject to certain restrictions which, e.g. demand that wastes must be pretreated and inerted before they are stored. These regulations favor thermal waste disposal methods such as the carbonization/combustion method which is planned for a commercial-scale plant in the city of Fuerth. (orig./BBR)

Energy Technology Data Exchange (ETDEWEB)

A respected veteran among state utility regulators raises a sober warning that it may not be possible for the telecommunications industry to survive half regulated and half unregulated, which is its posture for the present. He foresees a danger that the unregulated sector may be successful in capturing all the profitable portions of the market, leaving only the unprofitable areas to the regulated sector, which will then experience serious dislocations and even system breakdowns. Avoidance of such an outcome to the deregulatory steps presently being taken will require an uncommon degree of prudence and wisdom in those state officials who remain charged with regulatory responsibility for local exchange telephone facilities and service.

International Nuclear Information System (INIS)

Redd1, a recently discovered stress-response gene, is regulated by hypoxia via hypoxia-inducible factor 1 (HIF-1) and by DNA damage via p53/p63; however, the signaling pathway by which its expression is induced by hypoxia has not been elucidated. We demonstrated that the up-regulation of Redd1 transcription by hypoxia and high cell density (HCD) depends on cooperation between Sp1 and HIF-1#alpha# downstream of the PI3K/Akt pathway.

Energy Technology Data Exchange (ETDEWEB)

Jim Rogers, president and chief executive officer of Duke Energy Corporation, examines how coal and climate change regulations can co-exist. He addresses the need for economically sound choices for future energy needs, which is complicated by what he refers to as 'the elephant in the room'climate change. He observes that new CO{sub 2} regulations would increase the USA's cost of generating electricity over time and result in higher prices for customers, and he advocates that a gradual, economy-wide, market-based U.S. climate policy is the best option. 1 ref., 1 fig.

UK PubMed Central (United Kingdom)

Randomized clinical trials are designed with stopping boundaries to guide data monitoring committees with their decision making concerning ongoing trials. In particular, when extremely positive results...Full Text Available

UK PubMed Central (United Kingdom)

The cell wall envelopes of gram-positive bacteria represent a surface organelle that not only functions as a cytoskeletal element but also promotes interactions between bacteria and their environment....Full Text Available

UK PubMed Central (United Kingdom)

Beginning in 1990, gram-positive rods resembling Actinomyces pyogenes were found with increasing frequency in mixed cultures from various infectious processes, most of them from patients with otitis,...Full Text Available

UK PubMed Central (United Kingdom)

A 17-year-old H1N1-positive patient was successfully extubated after 25 days of ventilatory support for treatment of viral pneumonia which was complicated by empyema thoracis due to Candida...Full Text Available

UK PubMed Central (United Kingdom)

Purpose.The hypothesis that drivers with homonymous hemianopia (HH) would take a lane position that increased the safety margin on their blind side was tested with a driving simulator.Methods.Twelve...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The purpose of this hearing was to bring to the public`s attention a better understanding of both the shortcomings as well as the benefits of the existing wetlands regulations programs, policies and regulations. In addition an attempt was made to highlight those areas where there have been problems with restrictive or confusing regulations, time delays, and costs involved. Ultimately, the purpose is to identify areas in the federal regulations, and if necessary in the federal wetlands related laws, that can be amended, so these work better.

UK PubMed Central (United Kingdom)

Background. The role of vitamin D in the body's ability to fight influenza and URI's may be dependent on regulation of specific cytokines that participate in the host inflammatory...Full Text Available

UK PubMed Central (United Kingdom)

SummaryMammalian iron homeostasis is regulated by the interaction of the liver-produced peptide hepcidin and its receptor, the iron transporter ferroportin. Hepcidin binds to...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The history of the political process surrounding regulations is traced from the 1930s, when the natural gas industry and the Federal Power Commission were in their infancy. The author traces the changing mandate that Congress has provided the regulators and the instincts for self-preservation that these bureaucrats have manifested when they suspected a change in presidential administration or a new decision from the Supreme Court. Natural gas has been one political issue that has split Congress by region. The economic interests of producer and consumer states have often been at such odds that regulation has involved the question of redistribution of wealth among regions as well as between households and industry. The picture is complicated by the link between gas production and distribution and the production and distribution of coal and oil. 12 figures, 25 tables.

UK PubMed Central (United Kingdom)

Within the cardiac cell, the movements of calcium ions are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part...Full Text Available

UK PubMed Central (United Kingdom)

This manuscript discusses the physiology of the autonomic nervous system (ANS). The following topics are presented: regulation of activity; efferent pathways; sympathetic and parasympathetic divisions;...Full Text Available

UK PubMed Central (United Kingdom)

Phospholemman (PLM), a member of the FXYD family of regulators of ion transport, is a major sarcolemmal substrate for protein kinases A and C in cardiac and skeletal muscle. In the heart, PLM...Full Text Available

UK PubMed Central (United Kingdom)

The steroidal regulation of vertebrate neuroanatomy and neurophysiology includes a seemingly unending list of brain areas, cellular structures and behaviors modulated by these hormones. Estrogens,...Full Text Available

Science.gov (United States)

Divergence betyveen aircraft engine emission regulations pro- posed by EPA and ICAO is discussed Every engine, upon entering service, requires a certificate ...

UK PubMed Central (United Kingdom)

BackgroundMolecular genetic studies of Bombyx mori have led to profound advances in our understanding of the regulation of development. Bombyx mori brain,...Full Text Available

Science.gov (United States)

News Jobs Grants/Funding Families Prevention Diseases Regulations Preparedness Mental Health and Traumatic Events Find Local Mental Health Services Information for: Parents and...

International Nuclear Information System (INIS)

This report represents the timetables, responsible organizations, and methods required to comply with the newly promulgated Washington Administrative Code (WAC) 173-360 Underground Storage Tank (UST) Regulations which became effective December 29, 1990. This report only addresses UST systems that contain nonradioactive material. A total of 84 tanks at the Hanford Site are currently regulated under WAC 173-360. In addition, 32 regulated tanks have been removed as a result of the federally mandated program and the newly implemented state regulations. The majority of the USTs at the Hanford Site are operated by Westinghouse Hanford; however, one is operated by Kaiser Engineers Hanford (KEH) and one by Pacific Northwest Laboratory (PNL).

UK PubMed Central (United Kingdom)

Contractile vacuole complexes are critical components of cell volume regulation and have been shown to have other functional roles in several free-living protists....Full Text Available