UK PubMed Central (United Kingdom)

Immunomodulatory drugs lenalidomide and pomalidomide are synthetic compounds derived by modifying the chemical structure of thalidomide to improve its potency and reduce its side effects. Lenalidomide...Full Text Available

UK PubMed Central (United Kingdom)

Three photaffinity labeled derivatives of epothilone D were prepared by total synthesis, using efficient novel asymmetric synthesis methods for the preparation of two important synthetic building...Full Text Available

Science.gov (United States)

1,3-Dienes derived from steroidal D-ring C17-ketones undergo Ni(II)-catalyzed hydrovinylation to give 1,2- or 1,4-addition of ethylene. Using finely tuned phosphoramidite ligands it is possible to synthesize either the C20 (R)- or the C20 (S)-derivatives without mutual contamination. The proportion of the 1,4-adduct, which is also formed stereoselectively, can be minimized by optimizing the reaction conditions. Since the two alkenes in the resultant dienes have differing steric demands for many potential reactions, and are ideally juxtaposed for further D-ring functionalization, these intermediates could be useful for the preparation of biologically important compounds such as vitamin D analogs and various antitumor steroidal glycosides.

UK PubMed Central (United Kingdom)

Rejection of eight aldehydes, eight ketones, five secondary alcohols, and 3-pentanol has been studied in the blowfly Phormia regina Meigen. The data agree with results previously reported...Full Text Available

Science.gov (United States)

1,2,3-Trisilacyclopenta-1,4-diene 2, featuring three skeletal Si atoms in the five-membered ring, was synthesized by the thermolysis of the 1,2,3-trisilabicyclo[1.1.0]butane derivative 1 at 130 degrees C in the presence of hex-3-yne. Possessing the properties of nonconjugated cyclopentadiene, 2 readily underwent reduction with KC(8), which was followed by treatment with LiBr to form the lithium salt of 1,2,3-trisilacyclopentadienide 3(-)*[Li(+)(thf)], from which the ketone-coordinated derivative 3(-)*[Li(+)(O=C(t)Bu(2))] was prepared. Both 3(-)*[Li(+)(L)] (L = thf, O=C(t)Bu(2)) are classified as novel 6pi-electron aromatic systems based on their characteristic X-ray crystal and NMR spectral data. Addition of 12-crown-4 to 3(-)*[Li(+)(thf)] resulted in the unexpected formation of 4(-)*[Li(+)(12-crown-4)(2)], featuring the unprecedented cyclic disilenide ion 4(-). PMID:19378994

International Nuclear Information System (INIS)

Volatile compounds produced in flexible food packaging materials (LDPE, EVAc, PET/PE/EVOH/PE) during electron beam irradiation were isolated by purge and trap technique and identified by combined gas chromatography-mass spectrometry (GC/MS), after thermal desorption and concentration. For comparison purposes non-irradiated films were also studied. Film samples were irradiated at low (5 kGy, corresponding to cold pasteurization), intermediate (20 kGy, corresponding to cold sterilization) and high (100 kGy) doses. It was observed that a number of volatile compounds are produced after irradiation in all cases. Furthermore the amounts of all volatile compounds increase with increasing irradiation dose. Both primary (methyl-derivatives etc.) as well as secondary i.e. oxidation products (ketones, aldehydes, alcohols, carboxylic acids etc.) are produced upon irradiation. These products may affect organoleptic properties and thus shelf-life of ...

UK PubMed Central (United Kingdom)

The IgG response to gp41 (envelope glycoprotein of Mr 41,000) of the human immunodeficiency virus (HIV) was studied with eight synthetic peptides derived from three different regions of the protein....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Research is described in the development of organometallic reagents in which the boron was attached to a nonreactive organic or inorganic matrix such as polystyrene, silica, or alumina. We developed the synthesis of oxygen-15 labelled butanol, which has been found to be a valuable blood flow agent in humans. We have also developed a series of polymeric borane derivatives which were used to prepare nitrogen-13 labelled amines.

British Library Electronic Table of Contents (United Kingdom)

In this investigation, a forward osmosis (FO) dewatering process is evaluated as an alternative for dewatering orange peel press liquor. The press liquor is concentrated by removing water via osmosis into a concentrated ''draw solution'' across a polymeric cellulose acetate membrane. For this investigation, the draw solution consisted of sodium chloride at two different concentrations (2M and 4M). These draw solutions were used to concentrate synthetic press liquor. Concentration factors up to 3.7 resulted when using a 4M NaCl draw solution and the synthetic press liquor. Also during this investigation, fouling behavior was observed and the mechanisms of fouling elucidated through a systematic approach. This approach identified the key components of the press liquor that were primarily res...

Energy Technology Data Exchange (ETDEWEB)

Bacteriophage M13 mp10 DNA were irradiated with near-UV light in the presence of tetracycline derivatives and primed with synthetic oligonucleotide to be used for DNA synthesis using Escherichia coli DNA polymerase. Chain terminations were observed by denaturing polyacrylamide gel electrophoresis and mapped precisely. All the synthesis stops occurred before or at the level of guanine residues, showing that the photoreaction mediated by tetracycline derivatives led to a preferential alteration of guanine residues. These lesions were demonstrated to be induced in DNA through a pathway involving singlet oxygen. Tetracycline derivatives also photoinduced the breakage of the DNA sugar-phosphate backbone monitored by the conversion of supercoiled phi X174 DNA to a relaxed form. This lesion was shown to be initiated by hydroxyl radicals. The production of this free radical has been confirmed by electron ...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Energy Technology Data Exchange (ETDEWEB)

This patent describes a process for preparing poly(aryl ether ketones) by nucleophilic displacement polymerization in the presence of at least one alkali metal base selected from potassium, rubidium or cesium, and fluoride ions, which comprises adding to the polymerization: (a) an effective amount of at least one metal salt selected from lithium, sodium, alkaline earth or lanthanide chloride, bromide, iodide, sulfate, alkyl or aryl carboxylate, cyanide, borate or phosphate to slow or stop advancement of molecular weight and (b) an end-capping agent.

British Library Electronic Table of Contents (United Kingdom)

Alzheimer's disease (AD) is a neurodegenerative disorder for which the research of new treatments is highly challenging. Since the fibrillogenesis of amyloid-b peptide 1-42 (Ab1-42) peptide is considered as a major cause of neuronal degeneration, specific interest has been focused on aromatic molecules for targeting this peptide. In this paper, the synthesis of selegiline-functionalized and fluorescent poly(alkyl cyanoacrylate) nanoparticles (NPs) and their evaluation for the targeting of the Ab1-42 peptide are reported. The synthetic strategy relied on the design of amphiphilic copolymers by tandem Knoevenagel-Michael addition of cyanoacetate derivatives, followed by their self-assembly in aqueous solutions to give the corresponding NPs. Different cyanoacetates were used: (i) hexadecyl cy...

British Library Electronic Table of Contents (United Kingdom)

Natural rubber (NR) and its derivatives as renewable and biodegradable materials have attracted considerable attention because of the serious pollution problems caused by synthetic materials and a shortage of resources. A new semi-interpenetrating polymer network (semi-IPN) based on epoxidised natural rubber and polyvinyl alcohol containing maleic acid as a crosslinking reagent was synthesized and characterized by FTIR, XRD, SEM, swelling ratio in both distilled water and toluene, and mechanical properties. The curing time and dose of maleic acid were varied from 10 to 60min, and from 10 to 60% (w/w), respectively. An IR spectroscopic study indicated the presence of an ester linkage at 1730cm-1 in maleic acid crosslinked with PVA in semi-IPN films. In addition, the crystalline content of P...

International Nuclear Information System (INIS)

The concept of nanocrystal conversion chemistry, which involves the use of pre-formed nanoparticles as templates for chemical transformation into derivative solids, has emerged as a powerful approach for designing the synthesis of complex nanocrystalline solids. The general strategy exploits established synthetic capabilities in simple nanocrystal systems and uses these nanocrystals as templates that help to define the composition, crystal structure, and morphology of product nanocrystals. This article highlights key examples of 'conversion chemistry' approaches to the synthesis of nanocrystalline solids using a variety of techniques, including galvanic replacement, diffusion, oxidation, and ion exchange. The discussion is organized according to classes of solids, highlighting the diverse target systems that are accessible using similar chemical concepts: metals, oxides, chalcogenides, phosphides, alloys, intermetallic compounds, sulfides, and ...

Science.gov (United States)

Human space travelers experience a unique environment that affects homeostasis and physiologic

KoreaScience (Korea)

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Science.gov (United States)

The Economic Analysis (EA) report is written to address the impacts of this proposed Effluent Limitation Guidelines and Standards for Synthetic-Based and Other Non-Aqueous Drilling Fluids. Currently, effluent guidelines pertaining to the discharge of drilling fluids address two specific types of fluids: Oil-based drilling fluids (OBFs) that use diesel and mineral oil, which are prohibited from being discharged; and Water-based drilling Fluids (WBFs), which can be discharged subject to meeting certain discharge requirements, including a sheen test and an aqueous toxicity test, in certain limited offshore regions. Section Two presents sources of data, Section Three presents the industry profile, Section Four discusses the regulatory costs of options under consideration for the proposed rulemaking, and Section Five discusses the impacts of the proposed rule on firms, well drilling, and production, and also briefly discusses secondary impacts such as those on ...

Science.gov (United States)

A laser pyrolysis technique has been used to produce ultrafine particles of iron carbide with diameters ranging from 2 to 20 nm. Catalysis using iron carbide was investigated in the liquefaction of Wyodak subbituminous coal; yields were determined. A study was carried out to examine the possibility of using an ultrasonic extraction technique as a rapid method of product work-up of samples following pretreatment or liquefaction experiments. A similar study had shown that extraction of coal-derived products by an ultrasonic method was rapid and gave yields and product distributions comparable to those obtained by Soxhlet extraction. On another project, three different types of supported catalysts were used to test activity for the combined water-gas shift hydrogenation of a synthetic donor solvent. The three catalysts tested were: (1) Alumina supported NiMo catalyst-Shell 324m; (2) Bulk hydrous TiO NiMo catalyst; (3) Thin film hydrous TiO ...

UK PubMed Central (United Kingdom)

A commercially available synthetic nucleic acid probe (SNAP) conjugated to alkaline phosphatase was compared with standard culture techniques for detecting Campylobacter species. The SNAP was able to...Full Text Available

UK PubMed Central (United Kingdom)

The X-ray crystallographic structural determinations of synthetic estrogens and antiestrogens provide reliable information on the global minimum energy conformation of these molecules or a local minimum...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Several thin film composite nanofiltration membranes have been prepared by spin coating a sulfonated poly(ether ether ketone) solution on a polyethersulfone support, followed by thermal treatment. The most optimal developed nanofiltration membrane shows a clean water permeance of ~4.5Lm^-^2h^-^1bar^-^1 and a molecular weight cut off (MWCO) of ~500gmol^-^1. No irreversible changes in membrane performance have been observed after prolonged exposure (up to several weeks) of this membrane to solutions with a pH in the range 0-14. Compared to Desal-5-DK, the developed membrane displays a similar water permeance and a higher NaCl retention. In comparison to commercially available pH stable membranes, MPF-34 and NP030P, it reveals a higher water permeance. Permeance and MWCO analysis at varying p...

Science.gov (United States)

OF VOCALIZED SPEECH THROUGH. ANALYSIS OF NEURAL SIGNALS. " SYNTHETIC TELEPATHY- WIRELESS. TRANSMISSION OF DECODED. THOUGHTS. " IMPLANTABLE MEMORY-ELIMINATES ...

Science.gov (United States)

No abstract available.

Science.gov (United States)

Procedures are described for the use of synthetic oligonucleotides for Southern blot experiments and gene bank screening, and the effect of various mismatches on the efficiency of hybridization is demonstrated. The following topics are discussed: sensitivity vs. specificity, hybridization of a 12-mer to the lambda endolysin gene; hybridization of oligonucleotide probes to the E. coli lac operator; hybridization of synthetic probes to the CYC1 gene of yeast; and cloning eucaryotic genes. (HLW)

Science.gov (United States)

Kong-Ming Wu (Corresponding author) The application of recombinant DNA technology has resulted in many insect-resistant varieties by genetic engineering (GE). Crops expressing Cry toxins derived from Bacillus thuringiensis (Bt) have been planted worldwide, and are an effective tool for pest control. However, one ecological concern regarding the potential effects of insect-resistant GE plants on non-target organisms (NTOs) has been continually debated. In the present study, we briefly summarize the data regarding the development and commercial use of transgenic Bt varieties, elaborate on the procedure and methods for assessing the non-target effects of insect-resistant GE plants, and synthetically analyze the related research results, mostly those published between 2005 and 2010. A mass of laboratory and field studies have shown that the currently available Bt crops have no direct detrimental effects on NTOs due to their narrow spectrum of ...

Energy Technology Data Exchange (ETDEWEB)

As the jump from 2D to 3D, seismic exploration lives a new revolution with the use of converted PS waves. Indeed PS converted waves are proving their potential as a tool for imaging through gas; lithology discrimination; structural confirmation; and more. Nevertheless, processing converted shear data and in particular determining accurate P and S velocity models for depth imaging of these data is still a challenging problem, especially when the subsurface is anisotropic. To solve this velocity model determination problem we propose to use reflection travel time tomography. In a first step, we derive a new approximation of the exact phase velocity equation of the SV wave in anisotropic (TI) media. This new approximation is valid for non-weak anisotropy and is mathematically simpler to handle than the exact equation. Then, starting from an isotropic reflection tomography tool developed at Lt-'P, we extend the isotropic bending ray tracing method to the ...

Science.gov (United States)

... At no time must any solution or water temper- atures exceed 72°F, with all fluids maintained as close as possible to 700F. ...

UK PubMed Central (United Kingdom)

Synthetic polymers and nanomaterials display selective phenotypic effects in cells and in the body that affect signal transduction mechanisms involved in inflammation, differentiation, proliferation,...Full Text Available

Science.gov (United States)

Surface pressure measurements at mid span indicate that flow separation begins near ..... Turbomachinery Flows, AGARD Propulsion Energetics Panel, 1998. ...

Science.gov (United States)

The presence of two major aminopeptidases (aminopeptidases I and II) in the giant alga Chara australis was shown using polyacrylamide gel electrophoresis. Partially purified aminopeptidase I had a molecular weight of about 120,000, hydrolyzed both leucine-?-naphthylamide (pH optimum 6.0) and alanine-?-naphthylamide (pH optimum 7.5), and was located both inside and outside the vacuole. Aminopeptidase I was inhibited by p-chloromercuribenzoic acid, iodoacetic acid, 1,10-phenanthroline, and N-tosyl-l-phenylalanine chloromethyl ketone. Aminopeptidase II hydrolyzed alanine-?-naphthylamide but not leucine-?-naphthylamide and was located only outside the vacuole.ImagesFig. 1Fig. 2Fig. 4Fig. 5

International Nuclear Information System (INIS)

"2"0"3Pb, an ideal radionuclide for toxicological studies, can be artificially produced by bombardment of a thallium target but due to the extreme toxicity of thallium the lead has to be separated completely from the thallium. A single step method is here described consisting of removing the thallium from a dilute acid chloride solution using a continuous ethyl ether extraction. Essentially all of the thallium and almost none of the lead is removed in a 3-hr extraction. Because the ether is recycled, only about 30 ml are needed. If other contaminants are introduced from the bombardment and its subsequent manipulations, an additional step is used in which the lead is extracted from an iodide solution with methyl isopropyl keton. (U.K.).

British Library Electronic Table of Contents (United Kingdom)

The influence of headspace solid-phase microextraction (HS-SPME) variables, namely, sample concentration, salt concentration and sample amount, on the equilibrium headspace analysis of the main volatile flavor compounds released from soursop was investigated. A total of 35 volatile compounds, comprising 19 esters, six alcohols, three terpenes, two acids, two aromatics, two ketones and an aldehyde, were identified. The results indicated that all response-surface models were significantly (p<0.05) fitted for 10 target volatile flavor compounds. The results further indicated that more than 65% of the variation in the equilibrium headspace concentrations of target volatile flavor compounds could be explained by the final reduced models, with high R2 values ranging from 0.658 to 0.944. Multiple...

Science.gov (United States)

A clinical laboratory evaluation was conducted on the Clinitek Auto 2000, the Super Aution Analyzer and the Urotron RL9 for the determination of glucose, protein, pH, blood, ketone-bodies and bilirubin.Precision of the systems was tested using three commercial control urine materials, and reported as the percentage of times the instrument repeats a certain value. Good repeatability was obtained with all the instruments.Accuracy of the systems was evaluated by comparison with quantitative procedures, and to check agreement between methods yielding semi-quantitative and quantitative results, ranges of acceptability were defined, based on the criteria reported in a previous paper [2]. It was then found that 87.5 to 98.9% of results from the Urotron RL9 and the Clinitek Auto 2000 were acceptable. With the Super Aution Analyzer the level of agreement was apparently lower because of the higher number of concentration steps used by this instrument. PMID:18925198

International Nuclear Information System (INIS)

The molar heat capacities (Cp,m) of a series of synthetic forsterite (Fo)-fayalite (Fa), (Mg2SiO4+Fe2SiO4), olivines have been measured between 5K and 300K on milligram-sized samples with the Physical Properties Measurement System (Quantum Design(R)). Sharp, ?-type heat capacity anomalies are observed in the Fe-rich compositions fayalite, Fo10Fa90, Fo20Fa80, Fo30Fa70, and Fo40Fa60. The corresponding Neel temperatures TN decrease linearly from 64.5K in fayalite to 32.8K in Fo40Fa60 following the relationship TN=79.02.xFa-14.07. Fo50Fa50 and Mg-richer olivines show weak broad features in the heat capacity data around 15K to 20K that decrease in magnitude with increasing forsterite content. In order to derive and separate molar electronic, magnetic and vibrational heat capacity contributions, Cel,m, Cmag,m, and Cvib,m from the experimental heat capacities (Ctot,m), we used a single-parametric phonon dispersion model to calculate Cvib,m for the ...

Energy Technology Data Exchange (ETDEWEB)

The authors propose using synthetic aperture radar(SAR) for wind energy mapping of coastal zones. The SAR equipment is located on the European Space Agency ERS-1 and 2 and the RADARSAT satellites. Examples of wind energy maps and evaluations of their applications are given for the Norwegian west coast.

Energy Technology Data Exchange (ETDEWEB)

The resistance to microbe damages of aqueous solutions of cutting fluids (SOZh), which contain dual and more complex mixtures of known compounds, is studied. Lauric acid, myristic and tridecanic acid give microbic resistance to the compositions of synthetic cutting fluids. A complexing of the compositions as a rule does not support precisely expressed effects of synergism or antagonism.

Energy Technology Data Exchange (ETDEWEB)

The effect of a number of dietary and synthetic chelating agents on the intestinal absorption of lead has been examined using the everted sac preparation and the tracer isotope /sup 203/Pb. All the agents examined increased lead transport into the serosal compartment. An explanation of the way in which these agents modify the model to describe lead transport is proposed.

Energy Technology Data Exchange (ETDEWEB)

Short communication.

Energy Technology Data Exchange (ETDEWEB)

Brookhaven National Laboratory is involved in a conceptual design study of a commercial nuclear power system which utilizes high-temperature electrolysis to produce synthetic fuels. The system is called HYFIRE. It includes a tokamak fusion power reactor supplying electrical and thermal energy to an array of electrolytes. The electrolytes produce hydrogen which can be used either directly as a fuel or in the production of hydrocarbons. The purpose of the study is to provide a mechanism for DOE to further assess the commercial potential of fusion using a tokamak reactor to produce synthetic fuel. The HYFIRE design is based on the tokamak commercial power reactor, STARFIRE. STARFIRE uses the deuterium/tritium/lithium fuel cycle. The HYFIRE study assumes the plasma shape and characteristics of STARFIRE study but uses a different blanket design. This study is particularly interested in the possibility of using the STARFIRE tokamak in the production ...

UK PubMed Central (United Kingdom)

Oligonucleotide DNA probes complementary to the hypervariable region of the 16S rRNA of Bacteroides forsythus were tested for their specificity and sensitivity against reference and clinical isolates...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

In 1980, Congress passed the energy security act which created the United States Synthetic Fuels Corporation. This entity was created to serve as a catalyst for the development of synthetic fuels projects by the private sector. Then what happened. Increased exploration in the United States stimulated by relaxation of price controls on oil produced an increase in reserves of these resources. Fuel conservation, combined with a reduced energy demand caused by a recession, significantly reduced our overall energy consumption and curtailed our imports of foreign crude oil. All of these factors combined have reduced the enthusiasm to invest in synthetic fuels plants, in spite of the fact that the difference between surplus and shortage is frighteningly thin. South Africa, compared to the U.S., is a small country. The Sasol Two and Sasol Three projects are equivalent to a U.S. investment of $400 billion, on a country size-by-size ...

UK PubMed Central (United Kingdom)

Atg4 cysteine proteases (autophagins) play crucial roles in autophagy by proteolytic activation of Atg8 paralogs for targeting to autophagic vesicles by lipid conjugation, as well as in subsequent deconjugation...Full Text Available

UK PubMed Central (United Kingdom)

The production of an intramuscular (IM) injection of natural progesterone would provide a safer solution than using semi synthetic progesterone. However, disadvantages such as low solubility and a short...Full Text Available

UK PubMed Central (United Kingdom)

The natural biotic capacity of soils to degrade gamma-hexachlorocyclohexane (gamma-HCH, lindane) was estimated using an enrichment technique based on the ability of soil bacteria to develop on synthetic...Full Text Available

UK PubMed Central (United Kingdom)

Synthetic polypeptide antigens of L amino acids, although bearing repeating sequences, are thymus-dependent (L-TD), whereas the same polymers composed of D amino acids are thymus-independent (D-TI),...Full Text Available

UK PubMed Central (United Kingdom)

Lumbricus terrestris (Annelid, Oligocheta) is capable of cellular- and humoral-specific reactions against natural antigens. Is this earthworm able to elaborate a response of antibody type against a...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Ammonium sulfate is produced from spent sulfuric acid from the production of alcohols. Certain mineral and organic impurities exist in the sulfuric acid that impair the quality of the ammonium sulfate. A detailed method for the chemical analysis for the impurities is presented.

UK PubMed Central (United Kingdom)

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancy with dismal prognosis and few effective therapeutic options. Novel agents that are safe and effective are urgently...Full Text Available

UK PubMed Central (United Kingdom)

Synthetic complementary oligonucleotides are useful hybridization probes for the detection of mRNAs and genes encoding proteins for which only a partial amino acid sequence is known. Usually this involves...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This paper discussed the potential of biofuels with particular reference to the situation in Germany and Europe. Emphasis was on technical potential, such as biofuel production, utilization and environmental aspects. The Institute of Agricultural Technology and Biosystems Engineering ran vTI emission tests on diesel engines to evaluate the environmental impacts of biofuels. This testing facility is able to drive heavy-duty diesel engines in both stationary and dynamic test cycles, such as the European ESC and ETC. Additional analyses were conducted to determine the fine and ultra-fine particles, polycyclic aromatic hydrocarbons (PAH), aldehydes, ketones, and the usual regulated exhaust gas compounds. Ames tests were conducted to assess the mutagenic potential of tailpipe emissions. Previous study results showed that neat vegetable oils can render the exhaust high in mutagenic potency. Some of the non-regulated exhaust gas compounds were found to vary nonlinearly ...

Science.gov (United States)

Therapeutic hypothermia is a promising method for controlling intracranial pressure (ICP) in severely brain-injured patients. However, clinical data regarding the effect of brain hypothermia on overall outcome of these patients is limited. This may be because there are specific pitfalls associated with the clinical management of induced hypothermia in patients with severe traumatic brain injury (TBI). These pitfalls may be avoided by preventing specific risk factors when cooling is induced and with rewarming. However, these risk factors have not been well systematically discussed in the literature. In this paper, three categories of clinical issues regarding the management of brain hypothermia are discussed: (1) stress-induced secondary brain injury mechanisms; (2) technical aspects of intensive care unit (ICU) cooling management; and (3) rewarming rates and methods. For patients with a Glasgow Coma Scale (GCS) score of less than 8, management of stress-induced insulin-resistant ...

Energy Technology Data Exchange (ETDEWEB)

Ex situ and in situ fuel cell degradation of a sPAEK membrane were investigated. Post-mortem analyses of the aged membrane and of the degradation products eluted in water were carried out by NMR, IR, SEC and EDX. Ex situ agings were performed in a low concentration H{sub 2}O{sub 2} solution (0.07%) without any metallic catalyst. We exemplify that ex situ accelerated aging tests in such hydrogen peroxide solution are relevant to the chemical degradation in fuel cell. We have shown that a 500 h fuel cell test at moderate temperature (60 C) induces significant modifications on the macromolecules such as a 40% molecular weight reduction. Degradation appears heterogeneous and limited to the cathode side. The model compound approach developed in the previous article (Perrot et al.) has allowed the identification of the aging path in fuel cell. Phenolic and carboxylic acid chain ends have been identified as the main products resulting from polymer chain scissions. The ex situ lifetime (100 h) ...

Energy Technology Data Exchange (ETDEWEB)

The objectives of this project were to develop feasible synthetic routes to produce (1) 4(4{prime}-hydroxy-5{prime}6{prime},7{prime}8{prime}-tetrahydro-1{prime}-naphthylmethyl)-6-methyldibenzothiophene, and (2) a 1-hydroxynaphthalene-dibenzothiophene polymer. These compounds are thought to be representative of sulfur containing molecules in coal. The program was divided into two technical tasks. Unfortunately, the attempted syntheses of these compounds was unsuccessful due to their unusual reactivities. Attempted synthetic routes and possible future routes are described, and Appendix A lists the compounds that were synthesized during this program.

Energy Technology Data Exchange (ETDEWEB)

A high heating value, fuel pellet comprises from about 50 to about 99% by weight natural cellulosic material and from about 1 to about 50% by weight synthetic polymeric thermoplastic material. The synthetic thermoplastic material is uniformly distributed throughout the fuel pellet. The thermoplastic material is solid at room temperature and has an injection molding temperature of at least 200/sup 0/F. Such a fuel pellet can be prepared in a pelletizer where the temperature of the pellet as it emerges from the die is from about 150 to about 250/sup 0/F.

Energy Technology Data Exchange (ETDEWEB)

Synthetic detergents constitute one of the most important water pollutants by contaminating the lakes and rivers through domestic and industrial use. Considerable information is now available for the adverse effects of detergents an aquatic fauna including fish, algae, and higher aquatic plants. Marked inhibition of germination in orchids and brinjals and of seedlings growth in raddish suggest that rapidly growing systems could be sensitive to detergent polluted water. The present study of the effect of linear alkyl benzene sulphonate on germination of the spores of a fern, Diplazium esculentum aims at the understanding of the effects of water pollution on pteridophytes and the development of spore germination assay for phytoxicity evaluation.

UK PubMed Central (United Kingdom)

The mutagenic and cytotoxic activity of two newly synthesized doxorubicin derivatives and of one daunorubicin derivative were studied in V79 Chinese hamster cells and bacteria (Salmonella typhimurium...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Synthetic zeolite of 0.5 nm pore size (5A) and blue silica gel were tested to determine their capability to be used as radon collectors. Tests conducted in a radon chamber under controlled conditions of temperature and relative humidity indicate that simple, inexpensive and maintenance-free passive devices containing about 250 g of synthetic zeolite or about 270 g of blue silica gel in open face metal canisters that can measure radon conveniently and adequately, the latter though being suitable only for dry-medium dry atmosphere with quite high radon concentrations. Both materials can be recycled for reuse, in a way similar to the recycle and reuse of active carbon. The amount of radon adsorbed in such collectors is determined by counting the gamma rays from the radon decay products. The lower limit of detection (LLD) is estimated to {approx}45 Bqm{sup -3} for the synthetic zeolite and to {approx}350 Bqm{sup -3} for the ...

Energy Technology Data Exchange (ETDEWEB)

A great amount of naturally produced manganese dioxide has been widely used as cell active material since 1880's, but nowadays synthetic manganese dioxides such as electrolytic manganese dioxides (EMD) and chemically prepared manganese dioxides (CMD), etc. are used therefor and cell performances have considerably been improved. The synthetic manganese dioxides which are being used widely as the above cell active materials are active materials designed and reformed as manganese-oxygen-proton based active materials. In this study, electrochemical behaviors of synthetic manganese dioxides (layered manganese dioxides and spinel-related manganese dioxides) were examined in a 1MLiClO4 propylene carbonate/tetrahydrofuran (1:1) solution. A discharge curve shown by the layered manganese dioxide presented a distorted S-shape and that of the spinel-related manganese dioxide showed the two steps. The way of changes of crystal ...

Energy Technology Data Exchange (ETDEWEB)

Candidate materials for components of a fluidized-bed waste heat recovery system (FBWHRS) include plain carbon steel, types 405 and 316 stainless steel, and alloy 800. These materials were exposed to synthetic flue gas at anticipated FBWHRS temperatures and higher for 3000 h to determine corrosion rates. The synthetic flue gas was a combustion atmosphere to which Cl/sub 2/ and HCl were added. The projected annual corrosion rate for plain carbon steel is about 0.08 mm/year (0.003 in./year) at 250 to 290/sup 0/C, but it would exceed 0.5 mm/year (0.02 in./year) at 560/sup 0/C. The projected annual corrosion rates of the other materials were less than 0.25 mm/year (0.01 in./year) at the maximum test temperatures of 560, 660, and 665/sup 0/C for type 405, type 316, and alloy 800, respectively. These results indicate that corrosion of candidate FBWHRS materials will not be significant at anticipated operating temperatures for various components ...

Energy Technology Data Exchange (ETDEWEB)

Shale oil as a fuel source would need to compete with crude oil. The prospects for shale oil therefore depend upon the market outlook and likely prices for crude oil and its products. These are examined for both the world and Australia. For Australia, market prospects for shale oil are assessed in terms of maintaining a degree of self-sufficiency in petroleum fuels. Shale oil might also need to compete with other synthetic liquid fuels. The prospects for producing these in Australia are discussed. Some factors which might influence the pattern of development of a synthetic fuels industry in Australia are described and a role suggested for the federal government to ensure optimum development for national economic growth. 6 refs., 1 fig.

Energy Technology Data Exchange (ETDEWEB)

Sasol, a South-African company, has converted coal into synthetic fuels for 40 years; in order to increase by 6 pc its annual production (40 Mt coal are processed), Sasol has launched the Sky High project and intends to replace the ancient Sasol Synthol reactors by Advanced Synthol reactors using conventional fluidized beds instead of circulating fluidized beds. Coal is first gasified under high pressure and high temperature conditions (the Secunda site uses the Fischer-Tropsch conversion process) and is then processed in the reactor through a single phase process using an iron-base catalyst, leading to significant cost reductions.

Energy Technology Data Exchange (ETDEWEB)

A sequential research and development programme is considered for which several categories of related technologies are available to develop, each having the potential to produce some final product. At each stage of the programme, an optimal portfolio of technologies is chosen given the information acquired from the previous stages, and those contingent optimal plans are followed in all subsequent stages. The model is applied to coal liquefaction technologies to emphasize the costs that may be incurred by erroneously approaching the development programme as a once-and-for-all endeavour rather than in a sequential framework. The results of the synthetic oil application indicate that the acceleration of the programme may be optimal when the probability of successful development decreases. Under these conditions, adoption of a 'crash programme' in which all projects are researched simultaneously, may lead to deferral of synthetic ...

British Library Electronic Table of Contents (United Kingdom)

In this paper we demonstrate the capabilities of our ArcGIS-based software development that includes an adapted database system and a GIS tool for storage, combined analysis and visualization of leveling data and interferometric synthetic aperture radar (SAR) deformation measurements. Preprocessed remote sensing image data are stored with metadata that include all processing routines and parameters. This allows reproduction and traceability of all processing steps. Deformation monitoring is supported through data searching and selection based on a variety of criteria. A methods toolbox allows spatio-temporal analyses for points, lines and areas (e.g. subsidence basins) in a graphical manner.

British Library Electronic Table of Contents (United Kingdom)

Background, aim, and scope Semi-trailers with load boxes are the most important mode of grain transport by land in the world. Load boxes can be produced with different materials such as: wood, steel, and synthetic material. They are responsible for effectiveness retention and quality of grains during the transport. Among the main aspects to be considered and valued when selecting materials for load boxes are the final mass of the semi-trailer, loss of grains, and mechanical properties. Environmental performance is another important aspect to be taken into account for developing and selecting new materials in this kind of application. This study presents a comparative environmental evaluation of load boxes built from two different materials (a wood panel and a three-layer synthetic (TLS) pa...

Energy Technology Data Exchange (ETDEWEB)

Brief item.

KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

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Energy Technology Data Exchange (ETDEWEB)

Various physics applications involve the computation of the standard hypergeometric function {sub 2}F{sub 1} and its derivatives. Because it is not an intrinsic in the common programming languages, automatic differentiation tools will either differentiate through the code that computes {sub 2}F{sub 1} if that code is available or require the user to provide a hand-written derivative code. We present options for the derivative computation in the context of an ionization problem and compare the approach implemented in the Diamant library to standard methods.

KoreaScience (Korea)

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KoreaScience (Korea)

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International Nuclear Information System (INIS)

The usefulness of radioiodination via demetallation of aryltrimethylsilanes was demonstrated. The radioiodination reaction was found to be very rapid and the regiospecific incorporation of radioiodine could be carried out with high radiochemical yields and high radiospecific activity. "1"2"5I-Labeled dimethylaminoethyl iodophenoxyacetate derivatives (5a-e), dimethylaminoethyl iodophenoxyacetamide derivatives (7a-c), iodophenoxyethyl ethylenediamine derivatives (9,14) and an iodophenoxyethylpiperazine derivative (18) were efficiently synthesized from the corresponding aryltrimethylsilyl intermediates (4a-e, 6a-c, 8, 13, 17) by this method. (author).

Energy Technology Data Exchange (ETDEWEB)

The title composition comprises methanol containing stearic acid, C/sub 6/H/sub 6/, dextrin, phenol, a combustion accelerator (ethylene dichloride, xylene, Al stearate, a compound of acetic acid); a foaming agent; and ether and an antiknocking agent. The respective ignition point and boiling point of example compounds were 15.1-15.6/sup 0/ and 63.8-64.1/sup 0/.

Energy Technology Data Exchange (ETDEWEB)

With the aim of an experimental check on the validity of the theory of molecular recognition, the authors have carried out the chemical-enzymatic synthesis and cloning of the gene of human calcitonin and also of the genes of antisense polypeptides to human calcitonin and miniproinsulin. It has been shown that recombinant plasmids obtained on the basis of these synthetic genes are capable of ensuring the biosynthesis of the given polypeptides in E. coli cells as hybrid proteins with the IgG-binding domain of staphylococcal protein A.

British Library Electronic Table of Contents (United Kingdom)

Cycling parameters (reversible specific capacity, first-cycle coulombic efficiency, accumulated irreversible capacity, and reversible capacity retention) of hybrid electrodes based on mechanical mixtures of a silicon nanopowder with KS6 and MAG-20 synthetic graphites and binders of varied nature were subjected to an integrated analysis in comparison with graphite electrodes.

UK PubMed Central (United Kingdom)

A pro-drug 8 of a synthetic analog 7 is more active in its anti-proliferative activity against human breast cancer MDA-MB-231 cells possessing high Catechol-O-methyltransferase...Full Text Available

International Nuclear Information System (INIS)

New standardization techniques of samples in multielement instrumental neutron-activation analysis (INAA) of biological materials (BM) are considered. New methodical developments of sample preparation techniques, BM tableting, creation of comparison standards and standardization of packing material are suggested. Correlated data on concentration of different elements in standard specimens-comparison standards are presented for mass INAA, that is: for phenol-formaldehyde resin-base and human blood-base synthetic standards. 7 refs.; 3 tabs.

Energy Technology Data Exchange (ETDEWEB)

Several new development trends in the processing of methanol to various chemical products are discussed. The production of acetic acid by carbonylation of methanol will increase. In the future, methanol is expected to represent the raw material in the production of lower alkenes. The synthesis of lower alcohols, of synthetic gas (homologation), and of aromatic hydrocarbons from methanol are in the research stage.

Science.gov (United States)

In this Communication, we report the fabrication of well-crystallized rutile-phase TiO2 hollow spheres using potassium titanium oxalate as the precursor. The spheres exhibited unique three-dimensional hierarchical architectures and demonstrated a significantly improved photocatalytic performance. The synthetic strategy used in this process represents a general approach and therefore may contribute to the formation mechanisms of hollow nanostructures. PMID:16634578

Energy Technology Data Exchange (ETDEWEB)

A high voltage oil-impregnated electrical cable with fully polymer taped insulation operable to 765 kV. Biaxially oriented, specially processed, polyethylene, polybutene or polypropylene tape with an embossed pattern is wound in multiple layers over a conductive core with a permeable screen around the insulation. Conventional oil which closely matches the dielectric constant of the tape is used, and the cable can be impregnated after field installation because of its excellent impregnation characteristics.

UK PubMed Central (United Kingdom)

PurposeCurcumin (Cur) has been reported to induce apoptosis in human renal carcinoma Caki cells. Dimethoxycurcumin (DMC), one of several synthetic Cur analogues, has been reported...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The addition of 0.0005-0.5 weight% linoleic acid trimer to synthetic motor fuels composed of 95.0-99.8% technical-grade alcohol (EtOH or MeOH) and 0.2-5.0% water inhibits the corrosion induced by the impurities, such as aliphatic acids 0.5-10.0, aliphatic aldehydes 0.5-10.0, and aliphatic esters 0.5-10 mg/100 ml alcohol.

Energy Technology Data Exchange (ETDEWEB)

Most chemical reactions in industry and biology are catalytic and play a role at some stage of the processing of about 80% of the goods manufactured in the U.S., yet catalysis is a neglected subject in chemical education. This book integrates the fragmentary treatment accorded the topic until now. It covers, in a unified way, catalysis in solutions, by enzymes, in synthetic polymers within the molecular scale cages of zeolites and other molecular sieves, and on surfaces of inorganic solids. The central ideas are chemical; and principles are illustrated by emphasizing industrial reactions and catalysts.

Energy Technology Data Exchange (ETDEWEB)

(methine-{sup 3}H)1,1-Di-(4-chlorophenyl)-2,2,2-trichloroethane ((methine-{sup 3}H)DDT) and its di-(4-nitrophenyl) analog, both of high purity with a moderately high specific activity were prepared. Chloro-benzene was condensed with (1-{sup 3}H)1-(4-chlorophenyl)-2,2,2-trichloro-ethanol, which has been synthesized by sodium boro({sup 3}H)hydride reduction of 4-chlorophenyl trichloromethyl ketone. The purified ({sup 3}H)DDT had a specific activity of 0.77 Ci/mmol (28.49 GBq/mmol). (methine-{sup 3}H)1,1-Diphenyl-2,2,2-trichloroethane was similarly synthesized and was nitrated to give (methine-{sup 3}H)1,1-di-(4-nitrophenyl)-2,2,2-trichloro-ethane of 1.63 Ci/mmol (60.31 GBq/mmol). Dehydrochlorination with housefly enzyme (glutathione-dependent DDT dehydrochlorinase) showed a remarkable isotope effect. For DDT, the observed tritium isotope effect on V{sub max}/K{sub m} was 11.51{plus minus}0.52. For the nitro-analog, the value was 11.3{plus minus}1.2. We measured ...

Energy Technology Data Exchange (ETDEWEB)

The initial development of additives to stabilize the viscosity of biocrude during long-term storage has produced dramatic results. The additives investigated were ethyl acetate, methyl isobuyl ketone and methanol, acetone, methanol, acetone and methanol, and ethanol. These additives represent three chemical families, which all demonstrated the ability to drastically reduce the aging rate of biocrude, as defined by the increase in viscosity with time. Accelerated aging tests were run at 90{degree}C to screen the additives. The additives not only lowered the initial viscosity at 40{degree}C by half but also reduced the aging rate of a hot gas filtered pyrolysis oil made from hybrid poplar (NREL run 175) by factors of 1-18 compared to the original pure oil. With the best additive, methanol, at a 10 wt% level in the pyrolysis oil, the modified biocrude was still a single-phase liquid and still met the ASTM no. 4 diesel fuel specification for viscosity even after 96 h ...

UK PubMed Central (United Kingdom)

UV, first, second and third derivative spectrophotometric methods have been developed for the determination of ezetimibe in pharmaceutical formulation. The solutions of standard and sample were prepared...Full Text Available

International Nuclear Information System (INIS)

The excess molar volumes V_m"E for binary liquid mixtures containing dipropylene glycol monomethyl ether or dipropylene glycol monobutyl ether and methanol, 1-propanol, 1-pentanol and 1-heptanol have been measured as a function of composition using a continuous dilution dilatometer at T=(288.15, 298.15, and 308.15) K and atmospheric pressure over the whole concentration range. The excess volume results allowed the following mixing quantities to be reported in all range of concentrations or at equimolar concentrations: #alpha#, volume expansivity; (#partial deriv#V_m"E/#partial deriv#T)_p; (#partial deriv#H"E/#partial deriv#P)_T at T=298.15 K. The obtained results have been compared at T=298.15 K with the calculated values by using the Flory theory of liquid mixtures. The theory predicts the #alpha#, and #alpha#"E values rather well, while the calculated values of (#partial ...

International Nuclear Information System (INIS)

Ring opening dynamics of diarylethene derivative (BTF6) in n-hexane are studied by femtosecond transient absorption and time resolved spontaneous fluorescence techniques. Cyclo-reversion time constant is obtained.

UK PubMed Central (United Kingdom)

Platelet-derived growth factor (PDGF) is a potent moderator of soft tissue repair through induction of the inflammatory phase of repair and subsequent enhanced collagen deposition. We examined the effect...Full Text Available

UK PubMed Central (United Kingdom)

A series of N-alkylamide epoxides have shown considerable selective activity against insects. The N-ethyl and 7,11-dichloro-N-ethyl derivatives showed particularly pronounced activity, and this paper...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundDespite numerous treatments available for deteriorated cutaneous wound healing such as a diabetic foot, there is still the need for more effective therapy. Adipose-derived...Full Text Available

UK PubMed Central (United Kingdom)

In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403)...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundBacterial constituents, such as Gram-negative derived lipopolysaccharide (LPS), can initiate inflammatory bone loss through induction of host-derived inflammatory...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

International Nuclear Information System (INIS)

English 2006 2 p. Brazil Rocha, RM Centro Tecnico Aeroespacial, Sao

International Nuclear Information System (INIS)

This patent describes a radioiodinated benzodiazepine derivative. It comprises a lower alkyl group with 1-4 C-atoms and a radioactive iodine.

Science.gov (United States)

This study tested the prediction, derived from the goal-setting hypothesis, that the facilitating

CERN Document Server

Kaluza-Klein higher derivative induced gravity is studied for its application in the inflationary universe. The stability of an inflationary solution in a $D+4$-dimensional anisotropic space is analyzed carefully. We show that there is two nontrivial constraints derived from the static assumptions on the $D$-dimensional scale factor $d$ and scalar field $\\psi$. We find that a physical inflationary solution is consistent with the above constraints. In addition, a compact formula for the non-redundant $4+D$ dimensional Friedmann equation is also derived for convenience. Possible implications are also discussed in this paper.

CERN Document Server

Let $\\A$ be an irreducible Coxeter arrangement and $\\bfk$ be a multiplicity of $\\A$. We study the derivation module $D(\\A, \\bfk)$. Any two-dimensional irreducible Coxeter arrangement with even number of lines is decomposed into two orbits under the action of the Coxeter group. In this paper, we will {explicitly} construct a basis for $D(\\A, \\bfk)$ assuming $\\bfk$ is constant on each orbit. Consequently we will determine the exponents of $(\\A, \\bfk)$ under this assumption. For this purpose we develop a theory of universal derivations and introduce a map to deal with our exceptional cases.

Energy Technology Data Exchange (ETDEWEB)

The authors investigate anomalous terms in finite superconformal transformations in N = 4 SU(2)-extended superconformal algebras (SCA). Based on the superspace formalism they obtain super Schwarzian derivatives for the N = 4 SCA. Solutions for global superconformal transformations with the vanishing super-Schwarzian derivatives are given.

British Library Electronic Table of Contents (United Kingdom)

The thermodynamic characteristics of adsorption of proline and its hydroxy derivatives on the surface of graphitized thermal carbon black (GTCB) were calculated. The arrangement of hydroxyl groups in the amino acid molecule was shown to influence their adsorption on GTCB. The influence of internal rotation angles in proline and its hydroxy derivative molecules on their adsorption on GTCB was studied.

Energy Technology Data Exchange (ETDEWEB)

A formula for calculating the Dirac S-matrix for central Lorentz scalar and vector potentials is derived by use of a new amplitude-phase method. The derivation also makes use of certain invariants of the reduced 2-spinor radial Dirac equations.

International Nuclear Information System (INIS)

A consistent mathematical derivation is given for the Sommerfeld fine structure electromagnetic coupling 1/?-bar 0=?0-bar 1/137.036. Following 't Hooft's holographic principle two complimentary forms of the derivation are given both leading to the E(?) theoretical value, namely ?-bar 0=(20)(1/?)4=137.082039311. The experimental value is subsequently found by projection as ?-bar 0(exp)=137/[cos(?/?-bar 0)]-bar 137.036.

Energy Technology Data Exchange (ETDEWEB)

This paper introduces recent instances of polymerizers for highly viscous liquid needed in the field of synthetic resin and synthetic fiber. A horizontal twin-shaft type polymerizer has two horizontally rotating shafts with stirring blades of spectacle-shaped type, which are arranged at a 90 [degree] phase difference. As they rotate, they scrape highly viscous liquid sticking to the surface inside the polymerizer and on the rotating shafts. This polymerizer is capable of processing highly viscous liquid up to about 2000 Pa[center dot]s. A lattice-type twisting blade polymerizer is a vertical-type reactor and features a special stirring blade capable of stirring highly viscous liquid up to 5000 Pa[center dot]s This polymerizer has no central rotating shaft so that highly viscous liquid does not stick on it. A sloped blade-type thin-film evaporator has spiral blades in the longitudinal direction of the rotor. Process liquid pushed to the inner ...

Science.gov (United States)

The objectives of this project are to develop feasible synthetic routes to produce (1) 4(4`-hydroxy-5`,6`,7`,8`-tetrahydro-l`-naphthylmethyl )- 6-methyldibenzothiophene, and (2) a 1-hydroxynaphthalene-benzothiophene polymer. Our experimental work during this quarter concentrated on. As several possible synthetic routes to the target molecule, 4(4`-hydroxy-5`,6`,7`,8`-tetrahydro- l`-naphthylmethyl )-6-methyldibenzothiophene. We tried synthesizing the intermediates for our first method, in which we couple a metalated 4-methyldibenzothiophene with 4-formyl-5,6,7,8-tetrahydro-1-naphthol. We found that we could easily metalate dibenzothiophene, and then add a methyl group to the 4-position to give 4-methyldibenzothiophene in greater than 80% yield by using t-butyllithium in tetrahydropyran followed by dimethylsulfate. However, adding the second metal to the desired 4` position using the same method was more difficult, and instead the reaction ...

Energy Technology Data Exchange (ETDEWEB)

Strain-induced crystallization of crosslinked natural rubber (NR) and its synthetic analogue, cis-1,4-polyisoprene (IR), both mixed with various amounts of stearic acid (SA), were investigated by time-resolved X-ray diffraction using a powerful synchrotron radiation source and simultaneous mechanical (tensile) measurement. No acceleration or retardation was observed on NR in spite of the increase of SA amount. Even the SA-free IR crystallized upon stretching, and the overall crystallization behavior of IR shifted to the larger strain ratio with increasing SA content. No difference due to the SA was detected in the deformation of crystal lattice by stress for both NR and IR. These results suggested that the extended network chains are effective for the initiation of crystallization upon stretching, while the role of SA is trivial. These behaviors are much different from their crystallization at low temperature by standing, where SA acts as a nucleating agent.

Energy Technology Data Exchange (ETDEWEB)

Targeted studies completed include the evaluation of tritiated N-0437, evaluation of /sup 35/S-cysteamine, evaluation of /sup 18/F-FDG and initiation of synthetic efforts towards the synthesis of iodinated N-0437 and pergolide analogs. The direction of the project has been changed due to several factors which include the decided lack of favorable experimental results, the excellence of results using muscarinic receptor ligands in pituitary, brain and heart and the contention of the DOE review panel that the original grant proposal was based on flawed assumptions together with their perceived lack of importance to pituitary imaging. In the final year of this grant, three studies will be completed. The first study is the continuation of synthetic efforts to prepare iodinated N-0437 and pergolide analogs for possible use as brain imaging agents. The second study is directed towards completion of biochemical evaluation of various muscarinic ...

Science.gov (United States)

The US Department of Energy is carrying out a program of research and development to establish the capability to produce synthetic liquid fuels from coal. According to the National Energy Policy Plan IV, the Assistant Secretary of Fossil Energy is charged with carrying out a program to foster an adequate supply of energy at reasonable cost through innovative, long-term R and D. The payoff for this kind of research is potentially high if the country should need the capability on short notice. However, the research is also high risk in terms of the expectation of process for synthetic fuels to turn a profit for a private sector company. As the date when commercial quantities of synfuels will be needed has retreated before lower real prices of petroleum, the US DOE program for coal liquefaction has evolved to give increasing support to longer range, more exploratory technologies, rather than those nearly developed to the point where ...

Energy Technology Data Exchange (ETDEWEB)

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). Nature uses chlorophyll and other porphyrinic pigments to capture and transfer light energy as a preliminary step in photosynthesis. The design of synthetic assemblies of light harvesting and energy directing pigments has been explored through synthesis and characterization of porphyrin oligomers. In this project, pigment electronic and vibrational structures have been explored by electrochemistry and dynamic and static optical measurements. Transient absorption data reveal energy transfer between pigments with lifetimes on the order of 20--200 picoseconds, while Raman data reveal that the basic porphyrin core structure is unperturbed relative to the individual monomer units. These two findings, along with an extensive series of experiments on the oxidized oligomers, reveal that coupling between the pigments is ...

Science.gov (United States)

This paper proposes a new pattern recognition system employing optical joint transform correlation (JTC) technique which offers a great number of advantages over similar digital techniques, including very fast operation, simple architecture and capability of updating the reference image in real time. The proposed JTC technique incorporates a synthetic discriminant function (SDF) of the target image estimated from different training images to make the pattern recognition performance invariant to noise and distortion. It then involves four different phase-shifted versions of the same target SDF reference image, which are individually joint transform correlated with the given input scene. When the correlation signals are combined, it produces a single cross-correlation peak corresponding to each potential target present in the given input scene. The proposed technique also includes a fringe-adjusted filter to generate a delta-like correlation peak with high ...

British Library Electronic Table of Contents (United Kingdom)

Forty synthetic food colors were determined in drinks and candies by reversed-phase high-performance liquid chromatography with photodiode array detection. The following food colors were analyzed within 19min using a short analytical column (50mmx4.6mm i.d., 1.8mm) at 50degreeC with gradient elution: Ponceau 6R, Tartrazine, Fast yellow AB, Amaranth, Indigotine, Naphthol yellow S, Chrysoine, Ponceau 4R, Sunset yellow FCF, Red 10B, Orange G, Acid violet 7, Brilliant black PN, Allura red AC, Yellow 2G, Red 2G, Uranine, Fast red E, Green S, Ponceau 2R, Azorubine, Orange I, Quinoline yellow, Martius yellow, Ponceau SX, Ponceau 3R, Fast green FCF, Eosine, Brilliant blue FCF, Orange II, Orange RN, Acid blue 1, Erythrosine, Amido black 10B, Acid red 52, Patent blue V, Acid green 9, Phloxine B, Ben...

Science.gov (United States)

A simple one-step method to fabricate hierarchically porous TiO2/Pd composite hollow spheres without any template was developed by using solvothermal treatment. Pd nanoparticles (2-5 nm) were well dispersed in the mesopores of the TiO2 hollow spheres via in-situ reduction. In our experiment, polyvinylpyrrolidone played an important role in the synthetic process as the reducing agent and the connective material between TiO2 and Pd nanoparticles. HF species generated from solvothermal reaction leaded to the formation of TiO2 hollow spheres and Ostwald ripening was another main factor that affected the size and structure of the hollow spheres. The as-prepared TiO2/Pd composite hollow spheres exhibited high electrocatalytic activity towards the reduction of H2O2. The sensitivity was about 226.72 ?A mM-1 cm-2 with a detection limit of 3.81 ?M at a signal-to-noise ratio of 3. These results made the hierarchically porous TiO2/Pd composite a promising platform for ...

Science.gov (United States)

The effects of pH on the calcium phosphate phase, of Tris and of amino acids, such as aspartic acid, glutamic acid, and serine on hydroxyapatite formation and morphology, were studied in double diffusion experiments. In this system, hydroxyapatite was only formed when the pH was around 7.4 or higher for the duration of the reaction. A decrease in pH resulted in the transformation of hydroxyapatite to octacalcium phosphate. Amino acids and Tris or the buffering capacity of Tris have an effect on the morphology of the synthetic hydroxyapatite. The presence of the additive results in spheres consisting of needles, blades or plates depending on the reaction system. PMID:12175941

Science.gov (United States)

Research continued on the synthesis of model compounds for coal liquefaction research. This report covers the actual laboratory investigation performed during the reporting period in order to attain the stated objective of the project, viz, the synthesis of a model compound containing tetrahydronaphthalene, naphthalene and phenyl moieties linked by methylene, ethylene and ether bonds. The overall synthetic approach aimed at obtaining the end product has been broken down into three major steps that involve the synthesis of three key reactive intermediates. These are: (1) 3,5-dimethyl-5-bromobenzyl chloride, (2) 1-chloromethylene-2-hydroxytetralin and (3) 2-chloromethylene-1-hydroxynaphthalene.

Energy Technology Data Exchange (ETDEWEB)

Scientists of the Institute of Wood Chemistry of the Latvian Academy of Sciences have developed two highly efficient processes for producing furfural, a feedstock for varnishes, synthetic resins and plastics. It is made of production wastes, including branches and small-dimension timber. By one process, the raw material is chipped, treated first with diluted sulphuric acid and then with steam heated to 250 degrees C. The other uses concentrated sulphuric acid as a catalyst. Besides furfural, this process also yields sugar solutions used in alcohol and nutrient yeast production.

Energy Technology Data Exchange (ETDEWEB)

The discovery of nearly sixty molecules, often unstable or complexes, in the interstellar space has been one of the greatest surprises of contemporary astronomy. We may, indeed, be surprised that molecules having up to 13 atoms might be synthetized in an extremely diluted space and at a very low temperature. That these molecules are, most of all, organic molecules is another astonishing subject, at least for the non-specialist. The interstellar molecule formation is indeed well understood nowadays, at least for the simplest ones. This article takes stock of interstellar chemistry which is essentially an ionic chemistry very different from laboratory chemistry.

Science.gov (United States)

It is well known that contact with metals can be responsible for allergic contact dermatitis; also, there is experimental evidence that nickel ions are readily available on the surface of used coins containing nickel and copper. The aim of this study was to prove that metal powders of nickel (Ni), cobalt (Co) and chromium (Cr) dispersed in synthetic sweat are oxidised into respective ions that can permeate the skin. Suspensions of 5 g of metal powder (Ni, Co and Cr) in 100 mL of synthetic sweat at pH 6.5 were prepared and shaken with a stirring plate at room temperature for 30 min. Human skin membranes were set up in Franz-diffusion cells and 2 mL of the freshly made suspension were applied to the outer surface of the skin for 24h. The appearance of metal ions in the aqueous receptor phase (NaCl 0.9%) was quantified by Electro Thermal Atomic Absorption Spectroscopy (ETAAS). Also, metals ions were analysed using Differential Pulse Polarography ...

Science.gov (United States)

This bulletin traces development of high-pressure, coal and tar hydrogenation technology, based on an intensive review of pertinent literature. The bulletin written as part of the Bureau of Mines research program on synthetic liquid fuels covers the history and economics of the process; chemical aspects of hydrogenation of coal, tar, and middle oil; engineering aspects of converting coal and tar to liquid fuels, principally gasoline; and equipment for the process. The literature covered includes documents of United States and British governments, journals, and other publications. Bureau results in the hydrogenation field are also incorporated.

International Nuclear Information System (INIS)

Sixteen patients with PAGET's disease of bone underwent quantitative bone scintigraphy with "9"9"mTc-MDP before and after a long-term treatment with carbocalcitonin, a synthetic analogue of eel calcitonin. The radionuclide study consisted in the blood pool and bone uptake measurement and in the bone avidity calculation (bone uptake - blood pool ratio). In our patients, a significant decrease in bone uptake and bone avidity was found, whereas the blood pool remained statistically unchanged. This behaviour could be accounted for the shift of the compact bone to a lamellar pattern. (orig.).

Energy Technology Data Exchange (ETDEWEB)

The overall goal of the Coal Liquefaction Program of the Office of Coal Technology (OCT) is to develop the scientific and engineering knowledge base with which industry can bring economically competitive and environmentally acceptable advanced technology for manufacturing synthetic liquid fuels from coal into the marketplace when needed. The technical goal of the Coal Liquefaction Program is to seek advanced and innovative improvements over the state-of-the-art processes for coal liquefaction that can utilize all major parts of the US coal resource base. A technology description and discussion of program goals and strategy is provided in this report. 2 figs.

British Library Electronic Table of Contents (United Kingdom)

In this paper we describe a Ni-Sn intermetallic material obtained via template electroplating synthesis. The structure and the morphology of this material are investigated by X ray diffraction (XRD) and Scanning Electron Microscopy (SEM) analyses. We demonstrate that Ni-Sn behaves as a sub-micrometric electrode showing a favourable response when cycled in a lithium cell. The results here reported suggest that the template electroplating is a promising synthetic approach that can lead to an optimized structure and morphology of the Ni-Sn electrode, such as to confer it a role of a high capacity anode in advanced lithium ion batteries.

Science.gov (United States)

Platinum and ruthenium in carbon supported Pt and Pt-Ru catalysts were determined by direct and derivative spectrophotometric methods. Complexes of platinum and ruthenium with SnCl(3)(-) ligands (tin(II) chloride in HCl) were used to determine both metals in solutions obtained after digestion of the samples of the catalysts. Platinum in the Pt/C catalyst can be determined in solutions obtained by digestion of the samples in aqua regia. Derivative spectrophotometry was used to determine both metals in the presence of each other in solutions obtained after digestion of samples of the Pt-Ru/C catalyst in the mixture of HCl+HNO(3) (6:1). The first derivative at 377 nm (;zero-crossing' point of ruthenium) and the second-derivative values at 495 nm (;zero-crossing' point of platinum) were used to estimate the concentration of platinum and ruthenium, respectively. PMID:18967441

British Library Electronic Table of Contents (United Kingdom)

Derivative spectrophotometry and bivariate calibration algorithm were used for study of run of photooxidation of levomepromazine hydrochloride (LV). The actual concentrations of LV and its main degradation product levomepromazine sulphoxide (LV-SO) were calculated using data provided by applied methods. The direct reading of absorbance values at 302nm and 334nm were employed for quantification of LV and LV-SO, respectively, in the case of bivariate method. The derivative spectrophotometric method is based on transformation of zero-order spectra into first derivative. The values of first derivative at 334nm were used for quantification of LV while at 278nm for assay of LV-SO. The obtained quantitative data were applied for investigation of kinetics of photodegradation of LV.

International Nuclear Information System (INIS)

Aim: Compounds such "9"9"mTc-MDP and "9"9"mTc-HEDP are used regularly in bone scintigraphy for metastasis detection. The therapeutics properties of beta emitter radionuclides like "1"5"3Sm, "1"6"6Ho and "1"7"7Lu has been widely reported in literature being "1"7"7Lu the less developed for medical applications. With the purpose of study different radiopharmaceuticals alternatives, for metastasis bone palliation, we have evaluated, on a comparative basis, the labeling of "1"5"3Sm-MDP, "1"5"3Sm-HEDP, "1"6"6Ho-MDP, "1"6"6Ho-HEDP, "1"7"7Lu-MDP and "1"7"7Lu-HEDP from the exhibited radionuclidic purity and biological distribution point of view. Material and Methods: The radionuclides were produced at La Reina Research Reactor, Chilean Nuclear Energy Commission. The radionuclidic purity was determined by gamma-Ray spectrometry. The labeling was accomplished with MDP (Plenum) and HEDP synthesized in-house. The in-vitro affinity of labeled compounds to the mineral bone matrix was determined using ...

Energy Technology Data Exchange (ETDEWEB)

Coal liquefaction investigations required the availability of model compounds for mechanistic investigations. Towards this end, IITRI was funded to develop an approach for the synthesis of one of the target compound. This study was carried out in several phases as outlined here. Initial synthetic investigations on obtaining 2-tetrolol was carried out using high pressure and temperature reduction with Raney nickel catalyst. The next step consisted in incorporation of a hydroxymethyelene group at the C-3 position. This was successfully carried out utilizing 2-tetrolol, formaldehyde, and calcium oxide. An alternate improved method was developed using 3-carboxyl-2-naphthol. This required less time, gave a cheer product in higher yield. Efforts at the introduction of a chloromethylene group only yielded polymeric material or starting material in spite of protection the phenolic group by various groups. They synthesis of 3, 5-dimethyl-6- bromobenzyl chloride was ...

Science.gov (United States)

Microbial volatile organic compounds (MVOCs) emitted from the mould species Penicillium expansum, P. chrysogenum, Aspergillus versicolor, A. fumigatus, A. niger and Cladosporium cladosporoides were analyzed by means of solid phase microextraction (SPME) and GCMS. The mould species were cultivated on the synthetic agar dichloran chloramphenicol (DG 18) and on wet wall paper. The production of MVOCs was monitored over several weeks to detect changes in the emission rates between the initial stage and later periods of growth. The cultivation on the synthetic agar resulted in MVOC patterns with a wide variety of signals. In contrast, the growth on wet wall paper led to changed MVOC patterns with less signals. The emission rates were drastically reduced. Components emitted by all six fungi species on wall paper were 2-pentanol and 2-pentanone. 1-Octen-3-ol was emitted by five fungi species. 2-Pentanol was only detected in considerable amounts during ...

Science.gov (United States)

Two-component mixtures of dorzolamide hydrochloride and timolol maleate were assayed by first derivative and ratio derivative spectrophotometric methods. The first method, derivative spectrophotometry, by the zero-crossing measurements, was used due to the drugs closely overlapping absorption spectra. Linear calibration graphs of first derivative values at 250.3 nm for dorzolamide hydrochloride and 315.8 nm for timolol maleate. The second method, is based on ratio first derivative spectrophotometry, the amplitudes in the first derivative of the ratio spectra at 242.9 and at 223.5 nm were selected to determine dorzolamide and timolol maleate in the binary mixture. Calibration graphs were established for 8.0-30.0 microg ml(-1) for dorzolamide hydrochloride and 3.0-24.6 microg ml(-1) for timolol maleate in binary mixture. Good linearity, precision and selectivity ...

British Library Electronic Table of Contents (United Kingdom)

A simple formulation is presented for torsion analysis of hollow tubes with polygonal shapes. Thicknesses of segments of cross section can be different. Governing equations in term of Prandtl's stress function are used to derive the formulas. The derived formulas are so simple that computations can be carried out with a pocket calculator. Several examples are presented to show the accuracy and efficiency of the formulation. The obtained results are verified by accurate finite element solutions. It will be seen that the derived formulas can be useful for analysis of thin-walled and moderately thick-walled hollow tubes.

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According to enactment of reduced dose limit based on ICRP-60, the calculation of Derived Release Limits(DRL) on Wolsung NPPs was carried out. There are two methods of determination on DRL; that is MPC(Maximum Permissible Concentration) method and system analysis method. In order to use the system analysis method, lots of environmental data are necessary and complicated exposure pathway are considered. So we intend to apply MPC method that is sort of simple. In addition the calculated results were compared with derived release limit on Canadian nuclear power plant.

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The adsorption and corrosion inhibition behavior of three selected thiosemicarbazone derivatives, namely 3-pyridinecarboxaldehyde thiosemicarbazone (META), isonicotinaldehyde thiosemicarbazone (PARA) and 2-pyridinecarboxaldehyde thiosemicarbazone (ORTHO) at the nickel surface were studied electrochemically by Tafel and impedance methods and computationally by carrying out Monte Carlo searches of configurational space on nickel/thiosemicarbazone derivative system. Electrochemical measurements showed that the inhibition efficiency of these compounds increased with increase in their concentration. The recorded inhibition efficiencies of the three tested thiosemicarbazone increase in the order: META>PARA>ORTHO. Polarization studies showed that these compounds act as mixed-type inhibitors for n...

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... Each beam finite element was derived using Hamilton's principle and the following basic assumptions: the beam has an arbitrary amount of pretwist ...

Energy Technology Data Exchange (ETDEWEB)

Using the operator approach we reexamine the two-dimensional model describing a massive Fermi field interacting via derivative couplings with two massless Bose fields, one scalar and the other pseudoscalar. Performing a canonical transformation on the Bose field algebra, the Fermi field operator is written in terms of the Mandelstam soliton operator and the derivative-coupling (DC) model is mapped into the massive Thirring model with two vector-current-scalar-derivative interactions (Schroer-Thirring model). The DC model with massless fermions can be mapped into the massless Rothe-Stamatescu model with a Thirring interaction (massless Rothe-Stamatescu-Thirring model). Within the present approach the weak equivalence between the fermionic sector of the DC model and the massive Thirring model is exhibited compactly.

International Nuclear Information System (INIS)

A representation of tensors and spinors at a point of space-time as spin and conformally weighted functions on the unit sphere is derived. Methods for performing algebraic operations on tensors and spinors in this representation are discussed. (author).

British Library Electronic Table of Contents (United Kingdom)

Mono- and disubstituted novel derivatives of the heptaene nystatin analog 28,29-didehydronystatin A1 (S44HP, 1) were obtained by chemical modification of the exocyclic C-16 carboxyl and/or an amino group of mycosamine moiety. The strategy of preparation of mono- and double-modified polyene macrolides was based on the use of intermediate hydrophobic N-Fmoc (9-fluorenylmethoxycarbonyl) derivatives that facilitated the procedures of isolation and purification of new compounds. The antifungal activity of the new derivatives was first tested in vitro against yeasts and filamentous fungi, allowing the selection of the most active compounds that were subsequently tested for acute toxicity in mice. 2-(N,N-dimethylamino)ethylamide of 1 (2) and 2-(N,N-dimethylamino)ethylamide of N-fructopyranosyl-28...

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The synthesis and structural characterization of a novel In(III) complex is described. The reaction

British Library Electronic Table of Contents (United Kingdom)

Reactive blue 2 (RB-2) had been characterized as a relatively potent ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) inhibitor with some selectivity for NTPDase3. In search for the pharmacophore and to analyze structure-activity relationships we synthesized a series of truncated derivatives and analogs of RB-2, including 1-amino-2-sulfo-4-ar(alk)ylaminoanthraquinones, 1-amino-2-methyl-4-arylaminoanthraquinones, 1-amino-4-bromoanthraquinone 2-sulfonic acid esters and sulfonamides, and bis-(1-amino-4-bromoanthraquinone) sulfonamides, and investigated them in preparations of rat NTPDase1, 2, and 3 using a capillary electrophoresis assay. Several 1-amino-2-sulfo-4-ar(alk)ylaminoanthraquinone derivatives inhibited E-NTPDases in a concentration-dependent manner. The 2-sulfonate group ...

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Wall thickness measurement of pipe is very important of the structural integrity of the industrial plant. However, the radiography method has an advantage because the ability of penetrating the insulated pipe. This will have economic benefit for industry. Moreover, the era of digital radiography has more advantages because the speed of radiographic work, less exposure time and no chemical used for film development. Either the conventional radiography or digital radiology, the wall thickness measurement is using the tangential radiography technique (TRT). In case, of a large diameter, pipe (more than inches) the determination maximum penetration wall thickness must be taken into the consideration. This paper is revisited the mathematical derivation of the determination of wall thickness measurement based on tangential radiography technique (TRT). The mathematical approach used in this derivation is the Pythagoras theorem and geometrical ...

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... The phenol and cresylic acid stream is flashed in a thin film evaporator over a concentrated sulfuric acid mixture to remove pyridine type substances ...

British Library Electronic Table of Contents (United Kingdom)

The molecular environment of the key subdomain IIId of the internal ribosome entry site (IRES) element of hepatitis C virus (HCV) RNA in the binary complex with the human 40S ribosomal subunit was studied. To this end, HCV IRES derivatives bearing perfluorophenylazido groups activatable by mild UV at nucleotides G263 or A275 in the subdomain IIId stem were used. They were prepared by the complementary addressed modification of the corresponding RNA transcript with alkylating oligodeoxyribonucleotide derivatives. None of the RNA derivatives were shown to be crosslinked to the 18S rRNA. It was found that the photoreactive groups of the IRES G263 and A275 nucleotides are crosslinked to ribosomal proteins S3a, S14, and S16. For the IRES derivative with the photoreactive group in nucleotide G26...

UK PubMed Central (United Kingdom)

This study was carried out to determine the rate and types of injuries experienced by boardsailors. Results derive from: (a) a review of hospital medical records for water sports injuries, and (b) a...Full Text Available

International Nuclear Information System (INIS)

English 2004 2 p. Brazil Rocha, RM Centro Tecnico Aeroespacial (CTA),

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major radius of the toroidal containment volume. The containment time was calculated using equation (4) as derived in references 16 and 17. The solid ...

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... derived and which describes fundamentally flux enhancement across an artificial membrane or skin: Keywords: Transdermal drug delivery system. ...

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... The third series used a correlated parameter covariance matrix derived from a generic database of modeling uncertainty for space structures [5-1 ...

UK PubMed Central (United Kingdom)

We develop and investigate numerically a thermodynamically consistent model of two-dimensional multicomponent vesicles in an incompressible viscous fluid. The model is derived using an energy...Full Text Available

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Density functional theory calculations were performed to study the effects of different substituents and bridge groups on the heats of formation (HOFs), thermal stability, and detonation properties for a series of diiminotetrazole derivatives. The isodesmic reaction method was employed to calculate the HOFs of the derivatives using total energies obtained from electronic structure calculations. The bond dissociation energies and bond orders for the weakest bonds were analyzed to investigate the thermal stability of the diiminotetrazole derivatives. The detonation velocities and pressures were evaluated by using the semiempirical Kamlet-Jacobs equations, based on the theoretical densities and HOFs. These results provide basic information for the molecular design of novel high-energy density...

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Necessary conditions are derived for compact aggregates of solid matter to develop from loose local clumps of dust grains in a contracting protostellar cloud.

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PMID:17103063

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This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change ... ...

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This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change ... ...

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... Coastal Monitoring and Assessment, the University of Hawaii, BAE Systems Spectral Solutions and Analytical Laboratories of Hawaii, LLC. ... ...

KoreaScience (Korea)

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The avermectins were introduced in 1981 and constitute a potent new class of anthelmintic agents. They are naturally-derived products of microbial action displaying an exceptionally wide range of antiparasitic...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This report presents and discusses results from Task 5 of the study ''Fate of Mercury in Synthetic Gypsum Used for Wallboard Production,'' performed at a full-scale commercial wallboard plant. Synthetic gypsum produced by wet flue gas desulfurization (FGD) systems on coal-fired power plants is commonly used in the manufacture of wallboard. The FGD process is used to control the sulfur dioxide emissions which would result in acid rain if not controlled. This practice has long benefited the environment by recycling the FGD gypsum byproduct, which is becoming available in increasing quantities, decreasing the need to landfill this material, and increasing the sustainable design of the wallboard product. However, new concerns have arisen as recent mercury control strategies developed for power plants involve the capture of mercury in FGD systems. The objective of this study is to determine whether any mercury is ...

International Nuclear Information System (INIS)

The complex thermally stimulated luminescence (TSL) pattern of NaAlSi_3O_8 has been analyzed on transparent and opaque varieties of natural crystals and synthetic pure powder. The existence of seven additional peaks in the range 20 to 450 "0C following X-irradiation at room temperature (RT) is reported, also evaluated by the curve fitting method. The validity of the analysis is discussed in the light of detailed trap analysis of KAlSi_3O_8. An attempt has been made to probe the excistence of high temperature peaks beyond 450 "0C using UV stimulation at RT. All the TSL peaks analyzed follow a second-order kinetic process.

Science.gov (United States)

An enantiocontrolled route to aziridinomitosenes had been developed from l-serine methyl ester hydrochloride. The tetracyclic target ring system was assembled by an internal azomethine ylide cycloaddition reaction based on silver ion-assisted intramolecular oxazole alkylation and cyanide-induced ylide generation via a labile oxazoline intermediate (62 to 66). Other key steps include reductive detritylation of 26, methylation of the N-H aziridine 56, oxidation of the sensitive cyclohexenedione 68 to quinone 70, and carbamoylation using Fmoc-NCO. Although the aziridinomitosene tetracycle is sensitive, a range of protecting group manipulations and redox chemistry can be performed if suitable precautions are taken. A study of DNA alkylation by the first C-6,C-7-unsubstituted aziridinomitosene 11a has been carried out, and evidence for DNA cross-link formation involving nucleophilic addition to the quinone subunit is described. PMID:14677970

British Library Electronic Table of Contents (United Kingdom)

It was demonstrated that R 2?R 4 saturated monohydric alcohols can be synthesized from CO and H2 in the presence of Fe catalysts containing a carbon support of the Sibunit type with granule sizes of 3?5, 1?2, and 0.05?0.1 mm in a fixed-bed reactor at 3 MPa and 240?300?C. It was found that the activity of Fe/Sibunit catalysts and their selectivity for the formation of liquid synthetic products increased with the size of granules and the amount of iron. The catalysts make it possible to obtain fatty alcohols, in which the fraction of R 2?R 4 alcohols is as high as 75%, in yields to 56 g/m3.

International Nuclear Information System (INIS)

The synthetic process of polyethylene cation exchange capillary via radiation grafting polystyrene by simultaneous irradiation with "6"0Co #gamma#-ray source and sulfonation with concentrated H_2SO_4 was studied. The effects of dose, dose rate, monomer concentration, solvents, temperature and crosslinking agents on the graft copolymerization of styrene with polyethylene capillary were illustrated. The relationship between the radiation grafting conditions and the properties of ion-exchange capillary were examined. A polyethylene cation exchange capillary with I.D. 0.8 mm, length 20 m, exchange capacity 0.7 Meq/g 60% capacity in 10 s (flow rate 20 ml/min) was prepared. No significant loss of copacity was found from this ion-exchange capillary after 200 adsorption/regeneration cycles.

Energy Technology Data Exchange (ETDEWEB)

Formulas were developed based on an aqueous solution of hydrolyzed polyacrylonitrile widely used in the oil industry. The additive used consisted of products of industrial production: synthetic resin TEG-1 with hardening agent PEPA (polyehtylene polyamine) and technical formalin. The mixtures containing about 80-85% by volume 5% hydrolyzed polyacrylonitrile, 10-15% by volume of resin TEG-1 with hardening agent PEPA and 3-5% by volume formalin satisfy the requirements made for the plugging materials. The initial mixtures are distinguished by technological efficiency of preparation and have controllable hardening periods. Physical-chemical properties are given for the gel polymers. In the set of properties, the mixtures based on hydrolyzed polyacrylonitrile, resin TEG-1 with hardening agent PEPA and formalin can be recommended as plugging materials of temporary action with complex treatment of the heterogeneous beds.

International Nuclear Information System (INIS)

Treatment with gamma and electron radiation is becoming a common process for the sterilization of packages, mostly made of natural or synthetic plastics, used in the aseptic processing of foods and pharmaceuticals. The effect of irradiation on these materials is crucial for packaging engineering to understand the effects of these new treatments. Packaging material may be irradiated either prior to or after filling. The irradiation prior to filling is usually chosen for dairy products, processed food, beverages, pharmaceutical, and medical device industries in the United States, Europe, and Canada. Radiation effects on packaging material properties still need further investigation. This paper summarizes the work done by different groups and discusses recent developments in regulations and testing procedures in the field of packaging technology.

British Library Electronic Table of Contents (United Kingdom)

This work deals with a new route to modify polymer blend morphology in order to improve the porosity of gas diffusion layers (GDLs) for proton exchange membrane fuel cells (PEMFCs). First, electrically conductive polymer-based blends were carefully formulated using a twin-screw extrusion process. Blend electrical conductivity was ensured by the addition of high specific surface area carbon black and synthetic graphite flakes. Final GDL porosity, in particular its macroporosity, was generated by melt blending polyamide 11 (PA11) matrix with polystyrene (PS) followed by PS extraction with tetrahydrofuran (THF) solvent at room temperature. In order to improve GDL porosity by the optimisation of PS dispersion in the PA11 matrix, PA11/PS blends were compatibilised by the addition of 2 wt.-% of ...

British Library Electronic Table of Contents (United Kingdom)

Two plastic wastes (polyolefin-enriched and multicomponent), two lube oils (paraffinic and synthetic) and one coal-tar were assessed as individual and combined additives to coal blends for the production of blast furnace coke. The effects of adding 2wt.% of these additives or their mixtures (50:50 w/w) on the coking capacity of coal, coking pressure and coke quality parameters were investigated. It was found that the two plastic wastes reduce fluidity, whereas the addition of oils and tar helps to partially restore the fluidity of the coal-plastic blend. From the co-carbonization of the coking blend with the different wastes in a movable wall oven of over 15kg capacity, it was deduced that polyolefins have a detrimental effect on coking pressure. The addition of oils and tar to the coal-pl...

British Library Electronic Table of Contents (United Kingdom)

In the present study we quantified the residues of organophosphorus (e.g. ethion and chlorpyrifos), organochlorine (e.g. heptachlor, dicofol, ?-endosulfan, ?-endosulfan, endosulfan sulfate) and synthetic pyrethroid (e.g. cypermethrin and deltamethrin) pesticides in made tea, fresh tea leaves, soils and water bodies from selected tea gardens in the Dooars and Hill regions of West Bengal, India during April and November, 2006. The organophosphorus (OP) pesticide residues were detected in 100% substrate samples of made tea, fresh tea leaves and soil in the Dooars region. In the Hill region, 20% to 40% of the substrate samples contained residues of organophosphorus (OP) pesticides. The organochlorine (OC) pesticide residues were detected in 33% to 100% of the substrate samples, excluding the w...

British Library Electronic Table of Contents (United Kingdom)

The cover picture shows the fertile combination of synthetic chemistry and experimental physics, both permanently making central contributions to hot scientific topics in spite of being classical scientific disciplines with long-standing traditions. The displayed scientist struggles with the synthesis of cruciform structures (displayed on the black board) for single-molecule-transport investigations in a mechanically controlled break junction setup (sketched in the inset at the upper right corner). More information on the design and synthesis of the cruciform structures, such as their immobilization experiments, is found in the article by M. Calame, M. Mayor et al. on p. 833 ff. Serafin Pazdera is greatly acknowledged for the cover artwork.

Energy Technology Data Exchange (ETDEWEB)

Nano photonic materials are synthetically manufactured crystals at the nano scale with the target of creating a microstructure with a special electro-magnetic periodicity. Such nano photonic materials have the ability to control light propagation and thus are capable of creating photonic bandgaps in the frequency domain. We propose using nano photonic crystals as sensors to detect microdamage in composite materials. We demonstrate using a simulation model that a nano photonic sensor attached to a composite bar experiences a significant change in its bandgap profile when damage is induced in the composite bar. The model predicts the frequency response of the nano photonic sensor using the transfer matrix method. A damage metric to evaluate the change in the frequency response is developed. Successful developments of nano photonic sensors allow damage identification at scales not attainable using current sensing technologies.

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Speech perception integrates auditory and visual information. This is evidenced by the McGurk illusion where seeing the talking face influences the auditory phonetic percept and by the audiovisual detection advantage where seeing the talking face influences the detectability of the acoustic speech signal. Here, we show that identification of phonetic content and detection can be dissociated as speech-specific and non-specific audiovisual integration effects. To this end, we employed synthetically modified stimuli, sine wave speech (SWS), which is an impoverished speech signal that only observers informed of its speech-like nature recognize as speech. While the McGurk illusion only occurred for informed observers, the audiovisual detection advantage occurred for na?ve observers as well. Thi...

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Lie group methods provide a valuable tool for examininginvariance and non-uniqueness associated with geophysical inverseproblems. The techniques are particularly well suited for the study ofnon-linear inverse problems. Using the infinitesimal generators of thegroup it is possible to move within the null space in an iterativefashion. The key computational step in determining the symmetry groupsassociated with an inverse problem is the singular value decomposition(SVD) of a sparse matrix. I apply the methodology to the eikonal equationand examine the possible solutions associated with a crosswelltomographic experiment. Results from a synthetic test indicate that it ispossible to vary the velocity model significantly and still fit thereference arrival times. the approach is also applied to data fromcorosswell surveys conducted before and after a CO2 injection at the LostHills field in California. The results highlight the fact that a faultcross-cutting the region ...

Science.gov (United States)

The effect of treatment of Na-forms of zeolites with HCl solutions and of heat treatment of their NH/sub 4/-forms on the stability of aluminum-oxygen tetrahedra has been studied in this work by high-resolution NMR on /sup 29/Si nuclei, using the synthetic zeolites X, Y, and M (mordenite) as the objects of the study. The exchange capacity with respect to Na/sup +/ ions was determined by analyzing the equilibrium solutions after contact of the samples with 0.5 NH/sub 4/Cl solution on a flame photometer. The high-resolution /sup 29/Si NMR spectra of polycrystalline samples were recorded on an SKhR-200 spectrometer with a superconducting solenoid at a frequency of 39.75 MHz with ultrafast mechanical rotation (3 kHz) of the sample at the magic angle to the external magnetic field. The results obtained are given.

DEFF Research Database (Denmark)

The determination of conformational preferences in unfolded and disordered proteins is an important challenge in structural biology. We here describe an algorithm to optimize energy functions for the simulation of unfolded proteins. The procedure is based on the maximum likelihood principle and employs a fast and efficient gradient descent method to find the set of parameters of the energy function that best explain the experimental data. We first validate the method by using synthetic reference data, and subsequently apply the algorithms to data from nuclear magnetic resonance spin-labeling experiments on the Delta 131 Delta fragment of Staphylococcal nuclease. A significant strength of the procedure that we present is that it directly uses experimental data to optimize the energy parameters, without relying on the availability of high resolution structures. The procedure is fully general and can be applied to a range of experimental data and energy functions ...

International Nuclear Information System (INIS)

Stellar rotation velocities and velocity dispersions along three slit positions in M31 have been measured, and three-dimensional velocity and velocity dispersion fields are obtained in order to search for a central black hole. Synthetic apparent spectra are constructed to eliminate problems with the reaction of the Fourier quotient program to stellar population mixes. Models are constructed to explore parameter space. The large velocities and velocity gradients that are found imply that the total mass-to-light ratio rises sharply at r of 0.5 arcsec or less to values greater than 100. This is much larger than normal for old stellar populations. Velocity anisotropies are not a major uncertainty because of the rapid rotation. There is thus strong evidence for a dark central mass, probably a supermassive black hole. 48 references.

British Library Electronic Table of Contents (United Kingdom)

Extracts were prepared from leaf, bark, and seed of Azadirachta indica, leaf and seed of Prunus persica, bark of Mangifera indica, and leaf of Psidium guajava and were evaluated against Boophilus microplus. Of the eight extracts screened, the extracts prepared from the A. indica seed showed very high level of efficacy (80%) after 5?h of treatment. Besides the immediate effect on adult ticks, the egg-laying properties of the survived ticks was also assessed, and a significant reduction (P?A. indica seed extracts was noted in comparison to control. The efficacy of the neem seed extracts was compared with the commonly used synthetic pyrethroids, and comparable efficacy against B. microplus fed on animals treated with neem seed extracts and acaricide treated was noted. The possibility of using...

British Library Electronic Table of Contents (United Kingdom)

Abstract In this research, the efficiency of electrocoagulation treatment process using aluminum electrodes to treat synthetic wastewater containing Reactive Red198 (RR198) was studied. The effects of parameters such as voltage, time of reaction, electrode connection mode, initial dye concentration, electrolyte concentration, and inter electrode distance on dye removal efficiency were investigated. In addition, electrical energy consumption, electrode consumption, and operating cost at optimum condition have been investigated. The results showed that dye and chemical oxygen demand removals were 98.6 and 84%, respectively. Electrode consumption, energy consumption and operating cost were 0.052-kg/m3, 1.303-kWh/m3 and 0.256-US$/m3, respectively. Dye removal kinetic followed first order kinet...

British Library Electronic Table of Contents (United Kingdom)

Synthetic chemistry originally developed for the manufacture of chemically stable silica polyamine composites was adapted for the modification of fused silica capillaries for application in CE. Polyethyleneimine (PEI) and polyallylamine (PAA) were covalently bonded to the interior surface of fused silica capillaries utilizing 3-chloropropyltrichlorosilane (CPTCS) or 3-glycidoxypropyl-trimethoxysilane (GPTMS) to anchor the polymers to the surface. The surface-bound polymers were subsequently quaternized using methyl iodide (MeI). The resulting modified capillaries were studied using CE, and were shown to provide reproducible, stable, and robust anodic EOF throughout the pH range of 2-10. Surface modifications utilizing CPTCS could be rinsed with up to 6 M HCL or 1 M NaOH without significant...

British Library Electronic Table of Contents (United Kingdom)

We report a solution-phase synthetic route to copper nanoparticles with controllable size and shape. The synthesis of the nanoparticles is achieved by the reduction of copper(II) salt in aqueous solution with hydrazine under air atmosphere in the presence of poly(acrylic acid) (PAA) as capping agent. The results suggest that the pH plays a key role for the formation of pure copper nanoparticles, whereas the concentration of PAA is important for controlling the size and geometric shape of the nanoparticles. The average size of the copper nanoparticles can be varied from 30 to 80 nm, depending on the concentration of PAA. With a moderate amount of PAA, faceted crystalline copper nanoparticles are obtained. The as-synthesized copper nanoparticles appear red in color and are stable for weeks, ...

International Nuclear Information System (INIS)

Composite materials of synthetics (based on monomers, oligomers and thermoplastics) and of natural polymers (wood and other fibrous cellulosics) prepared by radiation processing, offer valuable structural materials with enhanced coupling forces between the components. The applied polymer chemistry of such composites shows several common features with that of radiation grafting. E.g. the polymerization rate of oligomer-monomer mixtures in wood remains in most cases proportional to the square-root of the initiating dose-rate, just as in the simultaneous grafting, demonstrating that the chain termination kinetics remain regularly bimolecular in the corresponding dose-rate ranges. In the processing experiences of such composites, low dose requirement, easy process-control, and good technical feasibility have been found for composites of wood with oligomer-monomer mixtures, for coconut fibres with unsaturated polyesters and for pretreated wood fibre with polypropylene.

British Library Electronic Table of Contents (United Kingdom)

Recently, great interest was paid to new technologies dealing with environmental aspect. Preservation of natural resources such as natural fibers forced the composite industry to search and examine "eco-friendly" components. Studies to find alternative reinforcements and resin systems that are environmentally friendly while providing the same performance as their synthetic counterparts are in continuous progress. The aim of this study is to investigate effect of different treatment process on the data palm fiber (DPF). Raw DPF underwent different surface modification methods such as alkali treatment with concentrations 0.5%, 1%, 1.5%, 2.5% and 5%, and acid treatment with 0.3, 0.9 and 1.6N. All treatments were performed at 100degreeC for 1h. The surface morphology, thermal gravimetry analys...

Energy Technology Data Exchange (ETDEWEB)

This final report for the Swiss Federal Office of Energy (SFOE) reports on work done in the area of gasification of biomass. The use of dung, manure and sewage sludge as sources of energy is described and discussed. Hydrothermal gasification is proposed as an alternative to conventional gas-phase processes. The aim of the project in this respect is discussed. Here, a catalytic process that demonstrates the gasification of wet biomass to synthetic natural gas (SNG) in a continuously operating plant on a laboratory scale is being looked at. Difficulties encountered in preliminary tests are discussed. Long-term catalyst stability and the installations for the demonstration of the process are discussed, and gasification tests with ethanol are commented on.

British Library Electronic Table of Contents (United Kingdom)

Bio-inspired palladium nanoparticles were synthesized by using banana peel extract (BPE), a non-toxic eco-friendly material. Boiled, crushed, acetone precipitated, air-dried peel powder was used to reduce palladium chloride. The palladium nanoparticles were characterized by using UV-Visible spectroscopy, scanning electron microscope-energy dispersive spectra (SEM-EDS) and X-ray diffraction (XRD) analysis. Dynamic light scattering (DLS) studies revealed the average size of nanoparticles to be 50nm. Fourier transform infra red spectroscopy (FTIR) implicated the role of carboxyl, amine and hydroxyl groups in the synthetic process. This paper thus describes a novel green method for the synthesis of palladium nanoparticles.

CERN Document Server

The Elman artificial neural network (ANN) (feedback connection) was used for seismic data filtering. The recurrent connection that characterizes this network offers the advantage of storing values from the previous time step to be used in the current time step. The proposed structure has the advantage of training simplicity by a back-propagation algorithm (steepest descent). Several trials were addressed on synthetic (with 10% and 50% of random and Gaussian noise) and real seismic data using respectively 10 to 30 neurons and a minimum of 60 neurons in the hidden layer. Both an iteration number up to 4000 and arrest criteria were used to obtain satisfactory performances. Application of such networks on real data shows that the filtered seismic section was efficient. Adequate cross-validation test is done to ensure the performance of network on new data sets.

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The aim of this economic study is the wording of a synthetic document for the public information in the framework of the 98/30/CE european directive transposition to the gas internal market. It is writing in four main chapters, one for each country concerned: the Germany, the Spain, the Netherlands and the United Kingdom. Each one presents the historical context, the actors of the natural gas industry and the main provisions. (A.L.B.)

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Adsorption by activated red mud (ARM) is investigated as a possible alternative to the conventional methods of Cr(VI) removal from aqueous synthetic solutions and industrial effluents. Adsorption characteristics suggest the heterogenous nature of the adsorbent surface sites with respect to the energy of adsorption. Various factors such as pH, contact time, Cr(VI) concentration, amount of adsorbent, and temperature are taken into account, and promising results are obtained. The applicability of the Langmuir as well as Freundlich adsorption isotherms for the present system is tested. The loading factor (i.e., milligrams Cr(VI) adsorbed per gram of ARM) increased with initial Cr(VI) concentration, whereas a negative trend was observed with increasing temperature. The influence of the addition of anions on the adsorption of Cr(VI) depends on the relative affinity of the anions for the surface and the relative concentrations of the anions.

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The paper describes two schemes that follow the model of Lamarckian evolution and combine differential evolution (DE), which is a population-based stochastic global search method, with the local optimization algorithm of conjugate gradients (CG). In the first, each offspring is fine-tuned by CG before competing with their parents. In the other CG is used to improve both parents and offspring in a manner that is completely seamless for individuals that survive more than one generation. Experiments involved training weights of feed-forward neural networks to solve three synthetic and four real-life problems. In six out of seven cases the DE?CG hybrid, which preserves and uses information on each solution?s local optimization process, outperformed two recent variants of DE.

International Nuclear Information System (INIS)

The rare earth antimonates RE_3Sb_5O_1_2 constitute an isostructural series, where the rare earth site symmetry is S_4. The spectroscopic properties of pure or doped compounds of this family are studied in order to derive their energy level schemes and to simulate them through the crystal field theory, by using the approximated D_2_d potential. The paramagnetic susceptibilities are calculated with the derived wavefunctions and compared to experiment.

UK PubMed Central (United Kingdom)

Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions. These synthesized metal(II)...Full Text Available

CERN Document Server

Dwarf galaxies are generally faint. To derive their age and metallicity distributions, it is critical to optimize the use of any collected photon. Koleva et al., using full spectrum fitting, have found strong population gradients in some dwarf elliptical galaxies. Here, we show that the population profiles derived with this method are consistent and more precise than those obtained with spectrophotometric indices. This allows studying fainter objects in less telescope time.

Energy Technology Data Exchange (ETDEWEB)

The reduction of four-vector and electromagnetic fields produced by spin-1 tachyons has been derived in terms of standard helicity representations of inhomogeneous Lorentz group, and the conditions for these superluminal electromagnetic fields to satisfy the Maxwell's field equations have been derived. 16 refs.

International Nuclear Information System (INIS)

We investigate the q-deformation of the BRST algebra, the algebra of the ghost, matter and gauge fields on one spacetime point using the result of the bicovariant differential calculus. There are two nilpotent operations in the algebra, the BRST transformation #delta#_B and the derivative d. We show that one can define the covariant commutation relations among the fields and their derivatives consistently with these two operations as well as the *-operation, the antimultiplicative inner involution. (orig.).

Energy Technology Data Exchange (ETDEWEB)

Dithiolato-nickel complexes with multisulfur ligands derived from benzenehexathiolate have been synthesized. The properties of the monomeric and polymeric complexes have been characterized by ESR spectroscopic and magnetochemical data and by electrical conductivity measurements. The prepared complexes are paramagnetic and have characteristic absorptions between 800 and 1000 nm. (orig.).

Energy Technology Data Exchange (ETDEWEB)

This paper outlines the development of an organizational model which will be used to determine the influence of supervisory and management functions in a nuclear power plant (NPP) on risk. A theoretical conceptualization, derived from the empirical literature, is used to describe the organizational structure of NPPs. The parameters and variables associated with this dynamic, process-oriented model are detailed. Applications of the model and preliminary insights derived from this conceptualization are discussed.

Energy Technology Data Exchange (ETDEWEB)

A method is proposed for deriving hydrolized polyacrylonitrile from a water-based alkali solution. This process is meant to improve the thermal stability of clay drilling solutions by employing the hydrolized product to treat aliphatic non-water-soluble C/sub 8/-C/sub 16/ spirits in an organic dispersant during the presence of acidity and while the solution is being heated.

UK PubMed Central (United Kingdom)

The yeast phosphatidylinositol transfer protein (Sec14p) is required for biogenesis of Golgi-derived transport vesicles and cell viability, and this essential Sec14p requirement is abrogated by inactivation...Full Text Available

UK PubMed Central (United Kingdom)

Dendritic cells (DC) are the most potent antigen-presenting cells and play a central role in the induction of antiviral immune responses. Recently, we have shown that monocyte-derived DC (MoDC) from...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Explicit analytical formulas are derived for the stress intensity factors at the tips of a main crack and of a microcrack for the two-dimensional case of a collinear microcrack. This configuration is used to derive an estimate of the toughness degradation due to microcracks linking up with an advancing main crack. The implications of this estimate for theoretical predictions of the toughening due to stress-induced microcracking are discussed.

CERN Document Server

In the positive column of a neon glow discharge, two different types of ionization waves occur simultaneously. The low-dimensional chaos arising from the nonlinear interaction between the two waves is controlled by a continuous feedback technique. The control strategy is derived from the time-delayed autosynchronization method. Two spatially displaced points of observation are used to obtain the control information, using the propagation characteristics of the chaotic wave.

Energy Technology Data Exchange (ETDEWEB)

The available measurements on the cosmic-ray antiproton/proton ratio show an excess of antiprotons above predictions derived in the framework of the standard picture of cosmic-ray origin and propagation. Calculations are performed of the production from collisions of cosmic rays with the interstellar gas under the condition of distributed reacceleration. It could be shown that the calculated antiproton/proton ratio is enhanced compared to that derived from the leaky box model, but it remains difficult to bring it into agreement with the data by reasonable astrophysical assumptions. 15 references.