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Summary: The KEGG PATHWAY database provides a widely used service for metabolic and nonmetabolic pathways. It contains manually drawn pathway maps with information about the genes, reactions and relations contained therein. To store these pathways, KEGG uses KGML, a proprietary XML-format. Parsers and translators are needed to process the pathway maps for usage in other applications and algorithms. We have developed KEGGtranslator, an easy-to-use stand-alone application that can visualize and convert KGML formatted XML-files into multiple output formats. Unlike other translators, KEGGtranslator supports a plethora of output formats, is able to augment the information in translated documents (e.g. MIRIAM annotations) beyond the scope of the KGML document, and amends missing components to fr...

British Library Electronic Table of Contents (United Kingdom)

The thymus is a key organ of the immune system in most vertebrates and, for this reason, it has been used in this paper for the generation of a normalized cDNA library from sea bass (Dicentrarchus labrax), one of the most extensively cultured species in South Mediterranean aquaculture. A total of 1632 ESTs from this library were initially analysed for sequence quality and vector sequences and, after this control, 1264 (77% of total clones sequenced) high-quality ESTs were further processed. The total collection of D. labrax thymus ESTs has been deposited in the EBI-GenBank-DBJ database (GenBank accession numbers from FN565576 to FN566839). The functional classification of ESTs was performed by Gene Ontology and KEGG annotation and, successively, the sequences were analysed using the Immuno...

CERN Document Server

ACM Digital Library [Online database

Energy Technology Data Exchange (ETDEWEB)

The functioning of even a simple system is much more complicated than the sum of its genes, proteins and metabolites. A premise of systems biology is that molecular profiling will lead to the discovery and characterization of important disease pathways. However, as multiple levels of effector pathway regulation appear to be the norm rather than the exception, a significant challenge presented by high-throughput genomics and proteomics technologies is to extract the biological implications of complex data. Thus, integration of heterogeneous types of data generated from diverse global technology platforms represents the first challenge in developing the necessary foundational databases needed for predictive modeling of cell and tissue responses. Given the apparent difficulty in defining the correspondence between gene expression and protein abundance measured in several systems to date, how do we make sense of these data and ...

CERN Document Server

Pro SQL Server 2008 relational database design and implementation

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Page 1. Database Creation for Information Processing Methods, ... ARL-TN-0348 May 2009 Database Creation for Information Processing Methods, ...

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Many Asian countries have experienced rapid economic growth during recent years and this trend is expected to continue. The economic growth is accompanied by increasing energy demand, with coal as the dominant energy source. For the first time a model has been specifically developed and applied for integrated assessment of future SO{sub 2} emissions in Asia. The report deals with the RAINS-ASIA model developed in Norway offering an opportunity to assess sulphur deposition and ecosystem protection levels resulting from different energy pathways and different emission control strategies. The cost of various control strategies are also provided. During the project an impressive database has been collected for the region (23 countries, 94 subregions and 355 large point sources). This was made possible through dedicated work by the project team, in close collaboration with scientific and technical institutions in several Asian countries. A further ...

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A database has been developed to contain the disposal limits for the E-Area Low Level Waste Facility (ELLWF). This database originates in the form of an EXCEL{copyright} workbook. The pertinent sheets are translated to PDF format using Adobe ACROBAT{copyright}. The PDF version of the database is accessible from the Solid Waste Division web page on SHRINE. In addition to containing the various disposal unit limits, the database also contains hyperlinks to the original references for all limits. It is anticipated that database will be revised each time there is an addition, deletion or revision of any of the ELLWF radionuclide disposal limits.

UK PubMed Central (United Kingdom)

SummaryThe Hippo tumor-suppressor pathway controls tissue growth in Drosophila and mammals by regulating cell proliferation and apoptosis. The Hippo pathway includes...Full Text Available

KoreaScience (Korea)

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While autophagy has been shown to act as an anti-viral defense, the Picornaviridae avoid and, in many cases, subvert this pathway to promote their own replication. Evidence indicates...Full Text Available

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Treatment Induced Hypertension

DEFF Research Database (Denmark)

Udgivelsesdato: 2007/7

International Nuclear Information System (INIS)

Collection, analysis and quantification of human factor data are important compositions of human reliability analysis (HRA) and probabilistic risk assessment (PRA). Various human factor databases have been set up, but there are comparatively little human factor data management systems which can be uses for collection, classification, analysis, calculation and predication of the human factor data. Therefore, the human factor data management system for Daya Bay NPP is developed, with the following three modules and four databases: original data module, computing module, introduced data module, and basic database, other data source of the plant, external database and introduced database. The foundational problems about human factor data and the systemic structure and function are described. The data structure in the database is also discussed, because it is of the ...

UK PubMed Central (United Kingdom)

The viroid and viroid-like RNA database is a compilation of all natural sequences published in journals or available from the GenBank and EMBL nucleotide sequence libraries. Several information regarding...Full Text Available

UK PubMed Central (United Kingdom)

We present a methodology and database mediator tool for integrating modern knowledge-based systems, such as the Stanford EON architecture for automated guideline-based decision-support, with legacy...Full Text Available

UK PubMed Central (United Kingdom)

This paper describes Image Engine, an object-oriented, microcomputer-based, multimedia database designed to facilitate the storage and retrieval of digitized biomedical still images, video, and text...Full Text Available

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All these summaries will be included in the database from the published literature sources. (PSB)

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A preliminary database has been developed that will allow mineralogy and bulk-rock geochemical information to be managed under configuration control and facilitate electronic querying. The database is currently developed in Microsoft Access as a collection of tables, views, and entry forms. Each field and table has been described in a data dictionary.

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A method of increasing information content for content-based image retrieval (CBIR) systems includes the steps of providing a CBIR database, the database having an index for a plurality of stored digital images using a plurality of feature vectors, the feature vectors corresponding to distinct descriptive characteristics of the images. A visual similarity parameter value is calculated based on a degree of visual similarity between features vectors of an incoming image being considered for entry into the database and feature vectors associated with a most similar of the stored images. Based on said visual similarity parameter value it is determined whether to store or how long to store the feature vectors associated with the incoming image in the database.

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The phosphatidylinositol pathway is implicated in the regulation of numerous cellular functions and responses to extracellular signals. An important branching point in the pathway is the phosphorylation...Full Text Available

UK PubMed Central (United Kingdom)

Six species having characteristics of plants with the C₄ dicarboxylic photosynthetic pathway, Echinochloa utilis L. Ohwi et Yabuno (Japanese millet), Cynodon dactylon...Full Text Available

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Background & Aimsβ-catenin signaling within the canonical Wnt pathway is essential for pancreas development. However, the pathway is normally down-regulated...Full Text Available

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In this study we compared the molecular signalling elicited by rexinoids, selective retinoid X receptor (RXR)-activators, in several organs (i.e. liver, kidney,...Full Text Available

UK PubMed Central (United Kingdom)

Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Studies conducted over the past 10 to 15 years have revealed that...Full Text Available

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AIM: To investigate atrial natriuretic peptide (ANP) secretion from gastric mucosa and the relationship between the ANP/natriuretic peptide receptor type A (NPR-A) pathway and diabetic gastroparesis.METHODS:...Full Text Available

International Nuclear Information System (INIS)

... air pollution coprecipitation isotope production lead 203 proton beams

British Library Electronic Table of Contents (United Kingdom)

Abstract The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis. Deregulation of the Hippo pathway is linked to cancer development. Its first core kinase Warts was identified in Drosophila more than 15 years ago, but it gained much attention when other core components of the pathway were identified 8 years later. Major discoveries of the pathway were made during past several years. The core kinase components Hippo, Salvador, Warts, and Mats in the fly and Mst1/2, WW45, Lats1/2, and Mob1 in mammals phosphorylate and inactivate downstream transcriptional co-activators Yorkie in the fly, Yes-associated protein (YAP) and transcriptional co-activator with ...

Energy Technology Data Exchange (ETDEWEB)

As part of studies into the siting of a deep repository for nuclear waste, Swedish Nuclear Fuel and Waste Management Company (SKB) has commissioned the Alternative Models Project (AMP). The AMP is a comparison of three alternative modeling approaches for geosphere performance assessment for a single hypothetical site. The hypothetical site, arbitrarily named Aberg is based on parameters from the Aespoe Hard Rock Laboratory in southern Sweden. The Aberg model domain, boundary conditions and canister locations are defined as a common reference case to facilitate comparisons between approaches. This report presents the results of a discrete fracture pathways analysis of the Aberg site, within the context of the SR 97 performance assessment exercise. The Aberg discrete fracture network (DFN) site model is based on consensus Aberg parameters related to the Aespoe HRL site. Discrete fracture pathways are identified from canister locations in a ...

Science.gov (United States)

We describe a closed-loop brain-computer interface that re-ranks an image database by iterating between user generated 'interest' scores and computer vision generated visual similarity measures. The interest scores are based on decoding the electroencephalographic (EEG) correlates of target detection, attentional shifts and self-monitoring processes, which result from the user paying attention to target images interspersed in rapid serial visual presentation (RSVP) sequences. The highest scored images are passed to a semi-supervised computer vision system that reorganizes the image database accordingly, using a graph-based representation that captures visual similarity between images. The system can either query the user for more information, by adaptively resampling the database to create additional RSVP sequences, or it can converge to a 'done' state. The done state includes a final ranking of the image ...

CERN Document Server

We describe features of the LSST science database that are amenable to scientific data mining, object classification, outlier identification, anomaly detection, image quality assurance, and survey science validation. The data mining research agenda includes: scalability (at petabytes scales) of existing machine learning and data mining algorithms; development of grid-enabled parallel data mining algorithms; designing a robust system for brokering classifications from the LSST event pipeline (which may produce 10,000 or more event alerts per night); multi-resolution methods for exploration of petascale databases; indexing of multi-attribute multi-dimensional astronomical databases (beyond spatial indexing) for rapid querying of petabyte databases; and more.

UK PubMed Central (United Kingdom)

BackgroundThe availability of multiple, essentially complete genome sequences of prokaryotes and eukaryotes spurred both the demand and the opportunity for the construction of an...Full Text Available

UK PubMed Central (United Kingdom)

The primary purpose of PHOSIDA (http://www.phosida.com) is to manage posttranslational modification sites of various species...Full Text Available

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The Ames infrared spectral database of isolated, neutral and ionized polycyclic aromatic

Science.gov (United States)

... The third series used a correlated parameter covariance matrix derived from a generic database of modeling uncertainty for space structures [5-1 ...

Science.gov (United States)

May 25, 2007 ... This form will generate a bibliography of cost estimating references. The form will search the NASA Technical Report Service (NTRS) database ...

Energy Technology Data Exchange (ETDEWEB)

This paper discusses a database of information collected and organized during the past eight years from 2,000 producing oil wells in the United States, all of which have been treated with special applications techniques developed to improve the effectiveness of MEOR technology. The database, believed to be the first of its kind, has been generated for the purpose of statistically evaluating the effectiveness and economics of the MEOR process in a wide variety of oil reservoir environments, and is a tool that can be used to improve the predictability of treatment response. The information in the database has also been evaluated to determine which, if any, reservoir characteristics are dominant factors in determining the applicability of MEOR.

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This CD-ROM contains 34 contributions which were held on the 36th MPA seminar 2010 in Stuttgart (Germany). 32 contributions are separately analyzed for the ETDE database.

International Nuclear Information System (INIS)

The cross section database for electron impact excitation and electron impact ionization for hydrogen beam kinetic energies greater than 100 eV was considered, giving for each particular process a reference to a recommended publication of cross sections, as well as the accuracy or estimated accuracy. The work is motivated by the application of neutral beam injection in magnetic confinement devices, such as large tokamaks. 9 refs, 2 figs.

UK PubMed Central (United Kingdom)

The carcinogenicity database used for this paper originated in the late 1960s by the National Cancer Institute (NCI) and since 1978 has been continued and made more comprehensive by the National Toxicology...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYTestosterone and estrogen are essential for male behaviors in vertebrates. How these two signaling pathways interact to control masculinization of the brain and behavior...Full Text Available

UK PubMed Central (United Kingdom)

Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic events commandeer many signaling pathways that cooperate to endow aspiring...Full Text Available

UK PubMed Central (United Kingdom)

This manuscript discusses the physiology of the autonomic nervous system (ANS). The following topics are presented: regulation of activity; efferent pathways; sympathetic and parasympathetic divisions;...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Pathway analyses are regarded by National Plant Protection Organizations as a very efficient way to address the risks posed by invasive alien species. Data on import of aquatic plants was obtained from 10 EPPO countries (Austria, Czech Republic, Estonia, France, Germany, Hungary, the Netherlands, Latvia, Switzerland and Turkey) and aggregated in order to consider whether invasive or potentially invasive alien plants could be introduced in the EPPO region through this pathway. This study highlights that this pathway mainly consists of the import of tropical plants for use in aquaria, and which do not represent a risk due to their climatic requirements. However, a few species require thorough attention owing to the threats they cause. Of the 247 species recorded as imported, only 10 are curr...

Science.gov (United States)

The Liver Carcinogenesis Section uses the modern technologies of molecular biology, cell biology, protein chemistry and genetics to investigate the biochemical and genetic pathways involved in human liver cancer.

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The ingestion pathway consequences following an accidental tritium release from the Savannah River Site Tritium Facilities are evaluated.

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Turbine Afterword The SHARP cannon. Hydrogen is compressed in the tube on top, the gun barrel is on bottom. When Jules Verne wrote in 1865 "From Earth to the Moon" he envisioned...

UK PubMed Central (United Kingdom)

Pathways of salicylic acid (SA) biosynthesis and metabolism in tobacco have been recently identified. SA, an endogenous regulator of disease resistance, is a product of phenylpropanoid metabolism formed...Full Text Available

KoreaScience (Korea)

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UK PubMed Central (United Kingdom)

Glucose metabolism through glycolysis and hexosamine pathway has been shown to be altered in type 2 diabetes. However, its fate through the pentose phosphate pathway (PPP) is currently unclear....Full Text Available

UK PubMed Central (United Kingdom)

2,4-Dichlorophenoxyacetic acid (2,4-D) promotes the accumulation of tryptophan-derived indole-3-acetic acid (IAA) in carrot cell cultures during callus proliferation by a biosynthetic pathway that is...Full Text Available

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The insulin signaling pathway, involving protein kinase B (PKB) and mitogen-activated protein kinase (MAPK), mediates the biological response to insulin and several growth factors and cytokines. To investigate the correlation between glucose transporter (Glut) biosynthesis and the insulin signaling pathway activated by novel compounds of Liriope platyphylla (LP9M80-H), alterations in Glut and key protein expression in the insulin signaling pathway were analyzed in the liver and brain of ICR mice treated with LP9M80-H. An in vitro assay showed that the highest level of insulin concentration was observed in the LP9M80-H-treated group, followed by the LP-H, LP-M, LP-E, and LP9M80-C-treated groups. Therefore, LP9M80-H was selected for use in studying the detailed mechanism of the insulin signaling pathway in animal systems. In an in vivo experiment, LP9M80-H induced a significant increase in glucose levels ...

Science.gov (United States)

Up to the present, the generic values of the Common cause failure (CCF) event parameters have been used in most PSA projects for the Korean NPPs. However, the CCF analysis should be performed with plant specific information to meet Category II of the ASME PRA Standard. Therefore, we estimated the Alpha factor parameters of the emergency diesel generator (EDG) for Ulchin Unit 3 by using the International Common-Cause Failure data Exchange (ICDE) database. The ICDE database provides the member countries with only the information needed for an estimation of the CCF parameters. The Ulchin Unit A3, pressurized water reactor, has two onsite EDGs and one alternate AC (AAC) diesel generator. The onsite EDGs of Unit 3 and 4 and the AAC are manufactured by the same company, but they are designed differently. The estimation procedure of the Alpha factor used in this study follows the approach of the NUREG/CR-5485. Since we did not find any qualitative ...

Science.gov (United States)

Six species having characteristics of plants with the C(4) dicarboxylic photosynthetic pathway, Echinochloa utilis L. Ohwi et Yabuno (Japanese millet), Cynodon dactylon L. (Bermuda grass), Kyllinga brevifolia Rottb., Amaranthus tricolor L. cv. Early splendour, Kochia childsii Hort., and Portulaca grandiflora Hook (rose moss), responded decisively to 0.1 milliequivalent per liter NaCl supplied to their culture solutions initially containing less than 0.08 microequivalent per liter Na. Chlorosis and necrosis occurred in leaves of plants not receiving sodium. Portulaca failed to set flower in the sodium-deficient cultures. Under similar conditions Poa pratensis L. (Kentucky blue grass) having characteristics of the C(3) photosynthetic pathway made normal growth and did not respond to the addition of sodium. It is concluded from these results and previously reported work that sodium is generally essential for species having the C(4) ...

British Library Electronic Table of Contents (United Kingdom)

A large database (507 station-years) of daily suspended particulate matter (SPM) concentration and discharge data from 36 stations on river basins ranging from 600?km2 to 600,000?km2 in size (USA and Europe) was collected to assess the effects of SPM transport regime on bias and imprecision of flux estimates when using infrequent surveys and the discharge-weighted mean concentration method. By extracting individual SPM concentrations and corresponding discharge values from the database, sampling frequencies from 12 to 200 per year were simulated using Monte Carlo techniques. The resulting estimates of yearly SPM fluxes were compared to reference fluxes derived from the complete database. For each station and given frequency, bias was measured by the median of relative errors between estima...

UK PubMed Central (United Kingdom)

BackgroundA common approach to understanding the genetic basis of complex traits is through identification of associated quantitative trait loci (QTL). Fine mapping QTLs requires...Full Text Available

UK PubMed Central (United Kingdom)

SummaryAgeing is a complex, challenging phenomenon that will require multiple, interdisciplinary approaches to unravel its puzzles. To assist basic research on ageing, we developed...Full Text Available

Science.gov (United States)

Overview  Package   Class  Use  Tree  Deprecated  Index  Help   PREV CLASS   NEXT CLASS FRAMES    NO FRAMES SUMMARY:  INNER | FIELD | CONSTR | METHOD DETAIL:  FIELD | CONSTR | METHOD gov.nih.nci.dc.database Class SearchCriteria java.lang.Object |

Science.gov (United States)

Tutorial on digital libraries. Site also contains links to other reference materials on digital libraries as well as links to courses on the subject. Keywords: Information Systems - Information Systems Applications, Information Storage and Retrieval, Database Management, multimedia

UK PubMed Central (United Kingdom)

SummaryBackgroundThe US FDA has been collecting information on medical devices involved in significant adverse advents since 1984. These reports have...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundIn cancer research, the association between a gene and clinical outcome suggests the underlying etiology of the disease and consequently can motivate further studies. The...Full Text Available

CERN Document Server

The task of similarity search in multimedia databases is usually accomplished by range or k nearest neighbor queries. However, the expressing power of these "single-example" queries fails when the user's delicate query intent is not available as a single example. Recently, the well-known skyline operator was reused in metric similarity search as a "multi-example" query type. When applied on a multi-dimensional database (i.e., on a multi-attribute table), the traditional skyline operator selects all database objects that are not dominated by other objects. The metric skyline query adopts the skyline operator such that the multiple attributes are represented by distances (similarities) to multiple query examples. Hence, we can view the metric skyline as a set of representative database objects which are as similar to all the examples as possible and, simultaneously, are semantically distinct. In this ...

Wastenet

...Quality = $290,604 to improve permit compliance and appropriate preservation of wetlands by providing a spatial dataset to locate individual wetland permits on a property using high resolution imagery within specific regions of Virginia; this data set will be compared with the permit Comprehensive Environmental Database System that is currently used ...

Energy Technology Data Exchange (ETDEWEB)

The development of a computational intelligent tools based on neural network to identify commercial losses or fraud (theft energy), considering information from a database electric utility, is presented.

UK PubMed Central (United Kingdom)

Recent technological advances have lead to the ability to generate large amounts of data for model and non-model organisms. Whereas, in the past, there have been a relatively small number of central...Full Text Available

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This volume contains the proceedings of a symposium entitled In Vivo Imaging of Neurotransmitter Function in Brain, Heart, and Tumors'' held August 24--25, 1990 in Montreal Canada. The six individual papers contained herein are separately abstracted and indexed for the database.

UK PubMed Central (United Kingdom)

The Clinical Summary is a Web-based application for accessing the clinical database at the Massachusetts General Hospital. The application has been developed to give physicians in our health care community...Full Text Available

CERN Document Server

In recent years, discovery of association rules among itemsets in a large database has been described as an important database-mining problem. The problem of discovering association rules has received considerable research attention and several algorithms for mining frequent itemsets have been developed. Many algorithms have been proposed to discover rules at single concept level. However, mining association rules at multiple concept levels may lead to the discovery of more specific and concrete knowledge from data. The discovery of multiple level association rules is very much useful in many applications. In most of the studies for multiple level association rule mining, the database is scanned repeatedly which affects the efficiency of mining process. In this research paper, a new method for discovering multilevel association rules is proposed. It is based on FP-tree structure and uses cooccurrence frequent item tree to ...

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The constitutive model used to describe the deformation of crushed salt is presented in this report. Two mechanisms -- dislocation creep and grain boundary diffusional pressure solution -- are combined to form the basis for the constitutive model governing the deformation of crushed salt. The constitutive model is generalized to represent three-dimensional states of stress. Upon complete consolidation, the crushed-salt model reproduces the Multimechanism Deformation (M-D) model typically used for the Waste Isolation Pilot Plant (WIPP) host geological formation salt. New shear consolidation tests are combined with an existing database that includes hydrostatic consolidation and shear consolidation tests conducted on WIPP and southeastern New Mexico salt. Nonlinear least-squares model fitting to the database produced two sets of material parameter values for the model -- one for the shear consolidation tests and one for a combination of the shear ...

UK PubMed Central (United Kingdom)

We describe a decision support system to distinguish among hematology cases directly from microscopic specimens. The system uses an image database containing digitized specimens from normal...Full Text Available

UK PubMed Central (United Kingdom)

Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The purpose of this document is to summarize the findings of recent studies on the security problem in statistical databases and examine their applicability to the specific needs of CEDR. The document is organized as follows: In Section 2 we describe some general control methods which are available on most commercial database software. In Section 3 we provide a classification of statistical security methods. In Section 4 we analyze the type of users of CEDR and the security control methods which may be applied to each type. In Section 5 we summarize the findings of this study and recommend possible solutions.

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This document provides information on septic systems with a design capacity of greater than 14,500 gal/d and cribs submitted as requested by the Washington State Department of Ecology. Data for this submittal were taken from the Waste Information Database System (WIDS) and the Hanford Environmental Compliance Record (HECR) database. The current definition used in WIDS for an ''inactive facility'' is one that either no longer receives waste or plans to in the future. Information concerning the deactivation method for a facility is included when such information is available.

Energy Technology Data Exchange (ETDEWEB)

Data from many measuring devices throughout the Savannah River Site (SRS) is transmitted to a central location for processing as a vital component in the SRS emergency preparedness and response program. The data processing is currently accomplished using VAX-based FORTRAN programs with the data stored in Digital's Record Management System (RMS) files which is shared using global COMMON. A program is underway to store and process this data using a Structured Query Language (SQL)-based Database Management System (DBMS). The advantages of replacing the current system with one using an SQL-based DBMS are discussed.

Science.gov (United States)

Within the framework of the cluster approach and the semiempirical SCF MO LCAO method in the CNDO/BW valence approximation, possible pathways have been compared for the dehydroxylation of aluminosilicate systems. It has been shown that dehydroxylation as a result of splitting of a water molecule from an acidic bridge hydroxyl group and a more basic terminal group Al-OH is the most energyfavorable. Apparently, such a dehydroxylation pathway is primarily characteristic for amorphous aluminosilicates. Typical of crystalline aluminosilicates at moderate heat-treating temperature is dehydroxylation through splitting of a water molecule from an acidic bridge hydroxyl group and a neutral Si-OH group; at higher temperatures, there is a possible pathway of dehydroxylation of highsilica zeolites as a result of condensation of two acidic surface hydroxyls.

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The cyclic voltammetry indicated that the oxygen reduction reaction (ORR) proceeded by the four-electron pathway mechanism on larger Ag particles (174 nm), and that the ORR proceeded by the four-electron pathway and the two-electron pathway mechanisms on finer Ag particles (4.1 nm), simultaneously. The kinetics towards ORR was measured at a rotating disk electrode (RDE) with Ag/C electrode. The number of exchanged electrons for the ORR was found to be close to four on larger Ag particles (174 nm) and close to three on finer Ag particles (4.1 nm). The zinc-air battery with Ag/C catalysts (25.9 nm) was fabricated and examined. (author)

UK PubMed Central (United Kingdom)

The central nervous system regulates peripheral immune responses via the vagus nerve, the primary neural component of the cholinergic anti-inflammatory pathway. Electrical stimulation of the...Full Text Available

UK PubMed Central (United Kingdom)

Subcellular-fractionation techniques were used to characterize the endocytic pathway followed by ricin in rat liver in vivo and tentatively identify the site(s) at which the ricin interchain disulphide...Full Text Available

UK PubMed Central (United Kingdom)

While it has been established that microRNAs (miRNAs) play key roles throughout development and are dysregulated in many human pathologies, the specific processes and pathways regulated by individual...Full Text Available

UK PubMed Central (United Kingdom)

Purpose of ReviewThe vertebrate cap’n’collar family transcription factor Nrf2 and its invertebrate homologs SKN-1 (in worms) and CncC (in flies) function...Full Text Available

UK PubMed Central (United Kingdom)

p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array...Full Text Available

UK PubMed Central (United Kingdom)

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover,...Full Text Available

UK PubMed Central (United Kingdom)

The canonical Wnt/β-catenin pathway plays a pivotal role in regulating embryogenesis and tumorigenesis by promoting cell proliferation. BAMBI (BMP and activin membrane-bound inhibitor) has...Full Text Available

UK PubMed Central (United Kingdom)

The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53...Full Text Available

UK PubMed Central (United Kingdom)

Dal82p binds to the UIS_ALL sites of allophanate-induced genes of the allantoin-degradative pathway and functions synergistically with the GATA family Gln3p and Gat1p transcriptional...Full Text Available

UK PubMed Central (United Kingdom)

Cysticercosis is an infection with larval cysts of the cestode Taenia solium. Through pathways that are incompletely understood, dying parasites initiate a granulomatous reaction that,...Full Text Available

UK PubMed Central (United Kingdom)

Photosynthetic (Ps) electron transport pathways often contain multiple electron carriers with overlapping functions. Here we focus on two c-type cytochromes (cyt) in facultative phototrophic...Full Text Available

UK PubMed Central (United Kingdom)

The prevalence of obesity among children, adolescents and adults has been dramatically increasing worldwide during the last several decades. The obesity epidemic has been recognized as one of...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYSmall bowel epithelium is at the frontline of intestinal barrier function. Restitution is considered to be the major determinant of epithelial repair as function recovers...Full Text Available

UK PubMed Central (United Kingdom)

Previous studies in several different trigeminal nerve injury/inflammation models indicated that the hyperexcitability of primary afferent neurons contributes to the pain pathway underlying mechanical...Full Text Available

Science.gov (United States)

... Weiss, S., D. Kobiler, H. Levy, H. Marcus, A. Pass, N. Rothschild, and Z ... of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits ...

UK PubMed Central (United Kingdom)

BackgroundIn Saccharomyces cerevisiae galactose is initially metabolized through the Leloir pathway after which glucose 6-phosphate enters glycolysis. Galactose...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVE—Identification of arterial genes and pathways altered in obesity and diabetes.RESEARCH DESIGN AND METHODS—Aortic gene expression profiles of...Full Text Available

Wastenet

...this pathway study the following two focus modules (in addition to the six core modules) and carry out a research investigation within this theme: Agricultural Production Systems Considers the type of farming systems that have evolved globally in relation to the prevailing agro-climatic zones, the influences of economic factors ...

UK PubMed Central (United Kingdom)

BackgroundThe zebrafish is recognized as a versatile cancer and drug screening model. However, it is not known whether the estrogen-responsive genes and signaling pathways that are...Full Text Available

UK PubMed Central (United Kingdom)

As part of the study of cytokinin metabolic pathways, an enzyme, adenosine phosphorylase (EC 2.4.2.-), which catalyzed the ribosylation of N⁶-(Δ²-isopentenyl)adenine,...Full Text Available

UK PubMed Central (United Kingdom)

Spike-timing-dependent plasticity (STDP), a form of Hebbian plasticity, is inherently stabilizing. Whether and how GABAergic inhibition influences STDP is not well understood. Using a model neuron driven...Full Text Available

UK PubMed Central (United Kingdom)

Hematopoietic stem and progenitor cell (HSPC) expansion is regulated by intrinsic signaling pathways activated by cytokines. The intracellular kinase JAK2 plays an essential role in cytokine signaling,...Full Text Available

UK PubMed Central (United Kingdom)

Dysregulation of the alternative pathway of complement activation, caused by mutations or polymorphisms in the genes encoding factor H, membrane co-factor protein, factor I or factor B, is associated...Full Text Available

Science.gov (United States)

Summary.? It is widely believed that hepatocellular cancer (HCC), especially HBV associated HCC, is highly resistant to chemotherapy. To investigate the molecular influence of HBx protein on multidrug resistance (MDR) in HCC and the potential role of the NF-?B pathway in this process. We established HBx-expressing cells by liposome-mediated transfection of the HBx into the HepG2 cell line. We found that HBx expression in HCC cells induces drug resistance against multiple drugs, a significantly lower apoptosis ratio in HepG2-HBx and HepG2.2.15 cells, compared with HepG2 and HepG2-3.1 cells (P?HCC cells were downregulated by IMD-0354 treatment, which is the NF-?B pathway inhibitor. Taken together, these results suggest that HBx protein might be one of the causes for the occurrence of MDR in HCC, and the NF-?B pathway might be involved in this change. PMID:21914061

UK PubMed Central (United Kingdom)

Salicylic acid (SA) is an important component of systemic-acquired resistance in plants. It is synthesized from benzoic acid (BA) as part of the phenylpropanoid pathway. Benzaldehyde (BD), a potential...Full Text Available

UK PubMed Central (United Kingdom)

The intramembrane aspartyl protease γ-secretase plays a fundamental role in several signaling pathways involved in cellular differentiation and has been linked with a variety of human diseases,...Full Text Available

UK PubMed Central (United Kingdom)

Auxin modulates diverse plant developmental pathways through direct transcriptional regulation and cooperative signaling with other plant hormones. Genetic and biochemical approaches have clarified...Full Text Available

UK PubMed Central (United Kingdom)

The supramammillary nucleus (SuM) provides substantial projections to the hippocampal formation. This hypothalamic structure is involved in the regulation of hippocampal theta rhythm and therefore...Full Text Available

UK PubMed Central (United Kingdom)

Purpose of reviewSevere congenital neutropenia (SCN) is a primary immunodeficiency in which lack of neutrophils causes inadequate innate immune host response to bacterial...Full Text Available

UK PubMed Central (United Kingdom)

All eukaryotes require mitochondria for survival and growth. The origin of mitochondria can be traced down to a single endosymbiotic event between two probably prokaryotic organisms. Subsequent evolution...Full Text Available

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BackgroundNeurofibromatosis type 1 (NF1) is a common monogenic tumor-predisposition disorder that arises secondary to mutations in the tumor suppressor gene NF1....Full Text Available

UK PubMed Central (United Kingdom)

Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma,...Full Text Available

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The p21-activated kinases (PAKs), immediate downstream effectors of the small G-proteins of the Rac/cdc42 family, are critical mediators of signaling pathways regulating cellular behaviors and...Full Text Available

UK PubMed Central (United Kingdom)

It has previously been established that muscles become active in response to deviations from a threshold (referent) position of the body or its segments, and that intentional motor actions result from...Full Text Available

UK PubMed Central (United Kingdom)

Carbohydrate/citrate cometabolism in Lactococcus lactis results in the formation of the flavor compound acetoin. Resting cells of strain IL1403(pFL3) rapidly consumed citrate while...Full Text Available

UK PubMed Central (United Kingdom)

Store-operated Ca²⁺ entry (SOCE) is a ubiquitous Ca²⁺ influx pathway involved in control of multiple cellular and physiological processes including cell proliferation. Recent evidence...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundAs the first pathway-specific enzyme in carotenoid biosynthesis, phytoene synthase (PSY) is a prime regulatory target. This includes a number of biotechnological approaches...Full Text Available

UK PubMed Central (United Kingdom)

In most insect species, juvenile hormones regulate critical physiological processes such as metamorphosis and reproduction. In insects, these sesquiterpenoids are synthesized by retrocerebral endocrine...Full Text Available

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BackgroundNetwork visualization would serve as a useful first step for analysis. However, current graph layout algorithms for biological pathways are insensitive to biologically...Full Text Available

UK PubMed Central (United Kingdom)

IntroductionBRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known...Full Text Available

UK PubMed Central (United Kingdom)

Lovatt et al. (1979 Plant Physiol 64: 562-569) have previously demonstrated that end-product inhibition functions as a mechanism regulating the activity of the orotic acid pathway in...Full Text Available

Science.gov (United States)

Anxiety may cause adverse outcomes through physiologic pathways in patients with cardiac disease. The purpose of this dissertation was to investigate anxiety and its correlates in persons with acute myocardial infarction (AMI) and heart failure (HF). The ...

UK PubMed Central (United Kingdom)

Physical system conceptual models are developed to illustrate the various interconnecting pathways of metal flow. Economic use of mercury and cadmium, as representative toxic heavy metals, is inventoried,...Full Text Available

UK PubMed Central (United Kingdom)

Atherosclerosis is an inflammatory process leading to enhanced cellular proliferation, apoptosis, and vasa vasorum (VV) neovascularization. While both diabetes mellitus (DM) and hypercholesterolemia...Full Text Available

UK PubMed Central (United Kingdom)

Twenty-four patients with infective endocarditis (IE) are described, fourteen with Staph. aureus and ten with other organisms. Despite the acute nature of the infection, ten of the fourteen with Staph....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe pH is an important parameter controlling many metabolic and signalling pathways in living cells. Recombinant fluorescent pH indicators (pHluorins) have come into vogue...Full Text Available

International Nuclear Information System (INIS)

Redd1, a recently discovered stress-response gene, is regulated by hypoxia via hypoxia-inducible factor 1 (HIF-1) and by DNA damage via p53/p63; however, the signaling pathway by which its expression is induced by hypoxia has not been elucidated. We demonstrated that the up-regulation of Redd1 transcription by hypoxia and high cell density (HCD) depends on cooperation between Sp1 and HIF-1#alpha# downstream of the PI3K/Akt pathway.

British Library Electronic Table of Contents (United Kingdom)

Macroautophagy is a multistep, vacuolar, degradation pathway terminating in the lysosomal compartment, and it is of fundamental importance in tissue homeostasis. In this review, we consider macroautophagy in the light of recent advances in our understanding of the formation of autophagosomes, which are double-membrane-bound vacuoles that sequester cytoplasmic cargos and deliver them to lysosomes. In most cases, this final step is preceded by a maturation step during which autophagosomes interact with the endocytic pathway. The discovery of AuTophaGy-related genes has greatly increased our knowledge about the mechanism responsible for autophagosome formation, and there has also been progress in the understanding of molecular aspects of autophagosome maturation. Finally, the regulation of au...

Energy Technology Data Exchange (ETDEWEB)

Organic materials released from energy-related activities could affect human health and the environment. To better assess possible impacts, we developed a model to predict the fate of spills or discharges of pollutants into flowing or static bodies of fresh water. A computer code, Aquatic Pathways Model (APM), was written to implement the model. The computer programs use compartmental analysis to simulate aquatic ecosystems. The APM estimates the concentrations of chemicals in fish tissue, water and sediment, and is therefore useful for assessing exposure to humans through aquatic pathways. The APM will consider any aquatic pathway for which the user has transport data. Additionally, APM will estimate transport rates from physical and chemical properties of chemicals between several key compartments. The major pathways considered are biodegradation, fish and sediment uptake, photolysis, and evaporation. ...

Energy Technology Data Exchange (ETDEWEB)

The objective of the research is first to build a highly parallel processing system using 100 personal computers and an ATM switch. The former is a commodity for computer, while the latter can be regarded as a commodity for future communication systems. Second is to implement parallel relational database management system and parallel data mining system over the 100-PC cluster system. Third is to run decision-support queries typicalto data warehouses, to run association rule mining, and to prove the effectiveness of the proposed architecture as a next generation parallel database/datamining server. Performance/cost ratio of PC is significantly improved compared with workstations and proprietry systems due to its mass production. The cost of ATM switch is also considerably decreasing since ATM is being widely accepted as a communication-on infrastructure. By combining 100 PCs as computing commodities and ATM switch as a communication commodity, ...

Science.gov (United States)

Document search is generally based on individual terms in the document. However, for collections within limited domains it is possible to provide more powerful access tools. This paper describes a system designed for collections of reports of infectious disease outbreaks. The system, Proteus-BIO, automatically creates a table of outbreaks, with each table entry linked to the document describing that outbreak; this makes it possible to use database operations such as selection and sorting to find relevant documents. Proteus-BIO consists of a Web crawler which gathers relevant documents; an information extraction engine which converts the individual outbreak events to a tabular database; and a database browser which provides access to the events and, through them, to the documents. The information extraction engine uses sets of patterns and word classes to extract the information about each event. Preparing these patterns and ...

CERN Document Server

The LHCb Muon detector system is made of several (1368) Multi Wire Proportional Chambers (MWPCs). Those chambers differ in size, readout and constructing materials and are built in various countries: their assembly takes place in different sites and foresee many steps. To ensure the production quality and keep track of panels/chambers production an on-line database has been set up. This web based tool allows an easy sharing of the information: the database update is made possible trough a web interface. The update is easy and reliable. The interface helps the information sharing in different sites and helps optimizing the production rate by allowing feedback on production needs and quality between sites contributing to the production chain. The planning is made using the information on the material availability. Quality tests and crosschecks are made easier, as well as the overall production monitoring. The tool has been developed using mySQL, ...

British Library Electronic Table of Contents (United Kingdom)

The National Food and Nutrient Analysis Program (NFNAP) was designed to expand the quantity and improve the quality of data in the United States Department of Agriculture (USDA) food composition databases through the collection and analysis of nationally representative samples of foods and beverages. This paper describes some of the findings from the NFNAP and its impact on the food composition databases produced by USDA. The NFNAP employs statistically valid sampling plans, comprehensive quality control, and USDA analytical oversight to generate new and updated analytical data for food components. USDA food consumption and composition data were used to target those foods that are major contributors of nutrients of public health significance to the U.S. diet (454 Key Foods). Foods were ran...

CERN Document Server

This is a thought piece on data-intensive science requirements for databases and science centers. It argues that peta-scale datasets will be housed by science centers that provide substantial storage and processing for scientists who access the data via smart notebooks. Next-generation science instruments and simulations will generate these peta-scale datasets. The need to publish and share data and the need for generic analysis and visualization tools will finally create a convergence on common metadata standards. Database systems will be judged by their support of these metadata standards and by their ability to manage and access peta-scale datasets. The procedural stream-of-bytes-file-centric approach to data analysis is both too cumbersome and too serial for such large datasets. Non-procedural query and analysis of schematized self-describing data is both easier to use and allows much more parallelism.

Energy Technology Data Exchange (ETDEWEB)

The logic named Piccolo for a picture database computer and its implementation is presented. The logic is shown to have three major advantages. One advantage is that the computer design based on this logic can handle a universal variety of pictorial data structures. Another advantage is that a set of data generated by rules such as texture distribution rules is stored in the picture computer efficiently. The third advantage is that this logic can serve as the basis of a logic for parallel processing machines. For implementation of the logic, a new methodology named architecture engineering is introduced as an architecture/design oriented methodology. Implementation case studies show the usefulness of the methodolgy. Two implementations on an abstract machine that are also on a parallel LISP machine are reported. 19 references.

Energy Technology Data Exchange (ETDEWEB)

This report provides a brief summary of the milestone for Quarter 1 of 2006 of the NATional CARBon Sequestration Database and Geographic Information System (NATCARB) This milestone assigns consistent symbology to the ''National CO{sub 2} Facilities'' GIS layer on the NATCARB website. As a default, CO{sub 2} sources provided by the Regional Carbon Sequestration Partnerships and the National Group are now all one symbol type. In addition for sinks such as oil and gas fields where data is drawn from multiple partnerships, the symbology is given a single color. All these modifications are accomplished as the layer is passed through the national portal (www.natcarb.org). This documentation is sent to National Energy Technology Laboratory (NETL) as a Topical Report and will be included in the next Annual Report.

CERN Document Server

Landscapes are both a synthesis and an expression of national, regional and local cultural heritages. It is therefore very important to develop techniques aimed at cataloguing and archiving their forms. This paper discusses the LDL (Landscape Digital Library) project, a Web accessible database that can present the landscapes of a territory with documentary evidence in a new format and from a new perspective. The method was tested in a case study area of the river Po valley (Northern Italy). The LDL is based on a collection of photographs taken following a systematic grid of survey points identified through topographic cartography; the camera level is that of the human eye. This methodology leads to an innovative landscape archive that differs from surveys carried out through aerial photographs or campaigns aimed at selecting "relevant" points of interest. Further developments and possible uses of the LDL are also discussed.

International Nuclear Information System (INIS)

Nuclear forensics can provide information about the history, intended use and potentially the origin of nuclear or radioactive material. For these reasons, it is an important tool for improving nuclear security and combating illicit trafficking of nuclear and other radioactive materials. The IAEA is currently working on enhancing knowledge, techniques, procedures and cooperation in the field of nuclear forensics. Some of the work currently being undertaken by the IAEA includes the development of a five day training workshop on basic methods for radiological crime scene activities, to ensure adequate control of evidence, including for nuclear forensics purposes, a coordinated research project on the application of nuclear forensics in illicit trafficking, and a proposal for international cooperation with nuclear forensics databases and the development of guidelines for establishing databases. Nuclear forensics will continue to be an important ...

International Nuclear Information System (INIS)

The determination of the origin of seized nuclear material is important for authorities in the context of the criminal investigation, in order to return the material to its last legal owner and to help preventing any further diversion of material from this source. Origin determination is based on a complex pattern of parameters obtained through analytical measurements. The information required to determine the origin of nuclear materials may be divided into two categories: endogenous information (e.g. age or mode of production of the material) which is self-explanatory; whereas exogenous information (e.g. dimensions, surface roughness, impurities) requires a database to which the parameters can be compared. The Institute for Transuranium Elements has developed methods to determine characteristic parameters like impurities, surface roughness, or microstructural information. Furthermore, a database was set up containing relevant information on ...

International Nuclear Information System (INIS)

The Cycle 8A static tests conducted in the Fast Flux Test Facility (FFTF) during 1986 have resulted in the separation of various feedback reactivity components. These feedback components, described by closed-form equations depending only on the reactor temperature field, can be regarded as database for the validation and/or calibration of feedback mechanistic models. The SASSYS safety analysis code contains the most developed feedback reactivity models and was selected for the comparison study between database and mechanistic calculations for the FFTF. Although detailed feedback models for control rod repositioning and core radial expansion/bowing exist, only the simple models were available in SASSYS at the time of this study. The results are described in this paper.

Energy Technology Data Exchange (ETDEWEB)

A statistical method is developed to determine the locations of major pollutant sources affecting a distant downwind receptor, provided that air trajectories can be estimated. Probability density functions are estimated which indicate the overall residence time of air parcels over a given geographic region as they travel toward a receptor and residence time for the case of high pollutant concentrations at the receptor. These functions are used to estimate a conditional probability function which indicates the potential for a source region to contribute to high air pollution concentrations. Finally, a source contribution function is formulated to indicate the relative contribution of different source regions to high concentrations at the receptor. The method is tested using data collected at Grand Canyon National Park in 1980. The dominant pathway for air masses arriving at Grand Canyon during this period was southern California. A lesser ...

Science.gov (United States)

The C isotopic composition of CH4 emissions are strongly influenced by the pathway of CH4 formation. Contrary to data from other freshwater systems, soil gas and surface flux measurements made in the tropical rain forests of Puerto Rico strongly suggest that CH4 produced in these environments was derived from CO2 reduction, rather than from acetate consumption. This study explored the effects of bacterial competition for acetate, pH, and soil structure on the pathways of CH4 formation in tropical rain forest soils. Our goal was to test two principal hypotheses: (1) ferric iron-reducing bacteria out-competed methanogens for acetate, resulting in greater CO2 reduction rather than aceticlastic methanogenesis, and (2) the low pH of tropical rain forest soils favors CO2 reduction rather than aceticlastic methanogenesis. In addition, this study also investigated the effect of destroying soil aggregate structure on the pathways ...

International Nuclear Information System (INIS)

These proceedings represent papers presented at the Astrophysics Conference in Maryland, USA. The topic of the Conference was the evolution of x-ray binaries and the papers encompass a wide range of subjects on x-ray astronomy. There were one hundred eighteen papers presented at the Conference and out of these three have been abstracted for the Energy Science and Technology database.

Energy Technology Data Exchange (ETDEWEB)

The bibliography contains citations concerning the structural properties of sputtered tantalum and tantalum compounds. The preparation of thin film capacitors and resistors is described. The electrical properties of the sputtered films are also included. The influence of the substrate on the properties of the coatings is considered, including adherence of the coating to the substrate, and the effects of impurities on coating integrity. (Contains 250 citations and includes a subject term index and title list.)

Energy Technology Data Exchange (ETDEWEB)

This report contains studies which are part of the Bonneville Power Administration`s program to protect, mitigate, and enhance fish and wildlife affected by the development and operation of hydroelectric facilities on the Columbia River and its tributaries. Attention is focused on population monitoring studies in the Sawtooth Valley Lakes. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

International Nuclear Information System (INIS)

This paper discusses the clean-up of an Idaho National Engineering Laboratory (INEL) site utilized for disposal of transuranic contaminated waste from 1954 until 1970. The author presents requirements of the environmental protection statutes that have generated quality assurance requirements in addition to those historically implemented as a part of facility design, construction and operation. A hierarchy of program guidance quality documentation and procedures is discussed. Data qualification and computer database management are identified as requirements.

International Nuclear Information System (INIS)

This paper introduces an occupational exposure information system in detail, which is developed and in operation presently by Daya Bay nuclear power plant. It is presented in the paper that individual dose monitoring items and method, design and classification of database configuration, statistics and analysis of individual dose, and management of staff entering and exiting controlled area. The system is instructive to analysing individual dose and optimizing radiation protection measures. (authors)

Wastenet

...Identification - ETI Food & Biobased Research (WUR) Freudenthal Institute - FIsme (UU) Holst Centre IKM Engineering Ltd Information Retrieval and Information Systems (KUN) Information Systems - INS Information Technology Group (WUR) Institute for Computing and Information Sciences - ICIS (KUN) Institute of Health Policy and Management (EUR) ...

Energy Technology Data Exchange (ETDEWEB)

A correlation was developed for laminar film condensation on vertical fluted surfaces. The theoretical analysis of Panchal and Bell was used for defining important physical property groups. The experimental data of Combs et al. were used to validate the proposed correlation. The experimental database used in the present study included four flute geometries that could be approximated to cosine-type flutes and seven fluids. The resulting correlation can predict the average condensate heat transfer coefficient within {+-}20%.

Energy Technology Data Exchange (ETDEWEB)

The bibliography contains citations concerning the research and development of the electric automobile. Various sources of energy to accommodate electric cars, environmental effects, energy consumption and efficiency, and computer simulation and modeling relative to electric vehicle transportation are considered. Design variations are also included. (Contains a minimum of 121 citations and includes a subject term index and title list.)

International Nuclear Information System (INIS)

A bibliography is presented of unclassified published and in-house technical material written by members of the Accelerator Technology Division, Los Alamos National Laboratory, since its inception in January, 1978. The author and subject concordances in this report provide cross-reference to detailed citations kept in a computer database and a microfilm file of the documents. The citations include an abstract and other notes, and can be searched for key words and phrases.

International Nuclear Information System (INIS)

Full text of publication follows: Low activation ferritic/martensitic steels are receiving a high priority in the European long term materials research. Although extensively investigated, the available experimental data do not cover all required parameter ranges and cannot unambiguously be used to produce hardening/embrittlement trend curves. Therefore, the main objective of this work is to provide a physically-based engineering model offering a rational to experimental observations. From the literature, experimental data were selected to establish a database that mainly consists of 8 to 9Cr-steels irradiated in the range of 50 to 600 deg. C up to 30 dpa and with a He-content up to 5000 appm. The database includes neutron and proton irradiations, He-implanted as well as B- and Ni-doped steels. Because of the difficulty of interpretation inherent to the Charpy impact test, only tensile data were considered. The difficulty stems from the large ...

UK PubMed Central (United Kingdom)

MicroRNAs are short (∼22 nucleotides) noncoding RNAs that regulate the stability and translation of mRNA targets. A number of computational algorithms have been developed to help predict which...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly accounting for the vast majority of dementia. Recently, many studies have implicated the role of inflammatory response, especially neuroinflammatory response in the development and progression of AD. However, the underlying mechanism of how inflammatory response induces AD is unknown. Kynurenine pathway is a major route of the amino acid tryptophan catabolism, resulting in the production of nicotine adenine dinucleotide and other neuroactive intermediates: quinolinic acid (QA) and kynurenic acid (KA). QA exerts different toxic effects, including over-activation of N-methyl-d-aspartate (NMDA) receptor and excitotoxicity, synaptic dysfunction and neuronal death. On the other hand, KA is identified as the only...

British Library Electronic Table of Contents (United Kingdom)

The pore structure of volcanic clasts is examined using measurements of porosity, permeability, and electrical properties. Permeability varies by several orders of magnitude among volcanic clasts and does not depend solely upon porosity. Electrical property measurements of saturated volcanic samples illustrate the influence of pathway tortuosity and pore shape on permeability. For equivalent eruption conditions, silicic samples show higher tortuosities, smaller vesicle sizes, and lower permeabilities than mafic samples. These differences are largely due to variations in vesiculation and crystallization history. Differences between explosive and effusive samples reflect the relative ability of bubbles to form and maintain connected pathways during bubble expansion and collapse. Isotropic sa...

Energy Technology Data Exchange (ETDEWEB)

This paper reviews the molecular biology of the renin-angiotensin system. The renin gene structure is analyzed in detail, including an examination of the putative regulatory regions. The combined action of these regulatory sequences would result in the complex, tissue-specific expression and regulation observed in vivo. The expression of the tissue renin-angiotensin systems, which may have important physiological functions, is also described. In addition, the pathway of renin biosynthesis and secretion is reviewed. This includes speculation on the fate of circulating prorenin and the physiological role of multiple renin forms and secretory pathways. The molecular approaches described in this paper have greatly advanced our knowledge of the biology of the renin-angiotensin system. Future studies using these and other approaches should provide further insight into this complex system.

British Library Electronic Table of Contents (United Kingdom)

Many existing agents for diabetes therapy are unable to restore or maintain normal glucose homeostasis or prevent the eventual emergence of hyperglycemia-related complication. Therefore, agents based on novel mechanisms are sought to complement and extend the current therapeutic approaches. Based on the initial paper research, we focused on active STAT3 as an attractive pharmacological target for type 2 diabetes. The subsequent text mining with a unique query to identify suppressors but not activators of STAT3 revealed the ERK2/STAT3 pathway as a novel diabetes target. The description of ERK2 inhibitors as diabetes target had not been found in our text mining research at present. The mechanism-based peptide inhibitor for ERK2 was identified using the knowledge of the KIM sequence, which ha...

British Library Electronic Table of Contents (United Kingdom)

2-methylpropan-1-ol (isobutanol) is a leading candidate biofuel for the replacement or supplementation of current fossil fuels. Recent work has demonstrated glucose to isobutanol conversion through a modified amino acid pathway in a recombinant organism. Although anaerobic conditions are required for an economically competitive process, only aerobic isobutanol production has been feasible due to an imbalance in cofactor utilization. Two of the pathway enzymes, ketol-acid reductoisomerase and alcohol dehydrogenase, require nicotinamide dinucleotide phosphate (NADPH); glycolysis, however, produces only nicotinamide dinucleotide (NADH). Here, we compare two solutions to this imbalance problem: (1) over-expression of pyridine nucleotide transhydrogenase PntAB and (2) construction of an NADH-de...

British Library Electronic Table of Contents (United Kingdom)

Summary Background Sorafenib is an oral multikinase inhibitor that blocks cell proliferation via the ERK pathway and angiogenesis via the VEGF pathway. This phase II trial was conducted to determine the efficacy and tolerability of sorafenib for the treatment of patients with metastatic urothelial cancer (UC) who had not had prior chemotherapy for advanced disease. Patients and Methods Seventeen chemo-na?ve UC patients with adequate performance status and organ function were treated with sorafenib 400?mg twice daily on a continuous basis until progression or unacceptable toxicity. The primary endpoint was objective tumor response rate as measured by RECIST criteria. Secondary endpoints included rate of prolonged stable disease (>3?months), time to progression, median and 1?yr survival and ...

British Library Electronic Table of Contents (United Kingdom)

A range of 6-substituted imidazo[1,2-a]pyridines were synthesized using a multicomponent coupling reaction. Most of these compounds were found to exhibit excellent activity against the colon cancer cell lines HT-29 and Caco-2, whilst not showing significant toxicity against white blood cells. Our studies have shown that the proteolytic phase of apoptosis was initiated 2 h after treatment with these imidazo-[1,2-a]pyridines. The data suggests that the imidazo[1,2-a]pyridine-induced cell death in HT-29 and Caco-2 cells is mediated via pathway(s) that include the release of cytochrome c from the mitochondria to the cytosol and the activation of caspase 3 and caspase 8.

UK PubMed Central (United Kingdom)

Studies of ribulose-1,5-bisphosphate (RuBP) carboxylase from taxonomically diverse plants show that the enzyme from C₃ and crassulacean acid metabolism pathway species exhibits lower K_m(CO₂)...Full Text Available

UK PubMed Central (United Kingdom)

We tested the hypothesis that the basal release of nitric oxide (NO) from endothelial cells modulates contractile activity in the corpus cavernosum (CC) via inhibition of the RhoA/Rho-kinase signaling...Full Text Available

UK PubMed Central (United Kingdom)

Several early genes of murine cytomegalovirus (MCMV) encode proteins that mediate immune evasion by interference with the major histocompatibility complex class I (MHC-I) pathway of antigen presentation...Full Text Available

UK PubMed Central (United Kingdom)

We present evidence that the role of tryptophan and other potential intermediates in the pathways that could lead to indole derivatives needs to be reexamined. Two lines of Lemna gibba...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundWhen eukaryotic cells are deprived of amino acids, uncharged tRNAs accumulate and activate the conserved GCN2 protein kinase. Activated Gcn2p up-regulates the general amino...Full Text Available

Environmental Research Database

DescriptionThe recent sequencing of the complete genomes of several streptomycete species revealed the presence of a large number of cryptic' secondary metabolic gene clusters, and led to the realisation that these organisms have the ability to produce many more natural products than had previously been recognised. One of the aims of our work is to identify the physiological signals and regulatory mechanisms responsible for the activation of these 'cryptic' pathways, thus unleashing the full biosynthetic p [continued...

UK PubMed Central (United Kingdom)

The clinicopathologic features of 472 ovarian epithelial clear cell neoplasms (4 adenofibromas [AFs], 41 atypical proliferative [borderline] tumors [APTs], and 427 carcinomas [CAs]) were studied in...Full Text Available

UK PubMed Central (United Kingdom)

Hyperthermia (HT) is a strong adjuvant treatment with radiotherapy and chemotherapy because it causes tumor reoxygenation. However, the detailed molecular mechanisms of how HT enhances tumor oxygenation...Full Text Available

UK PubMed Central (United Kingdom)

Despite intensive efforts, the intracellular signaling pathways that mediate apoptosis remain unclear. The human B lymphoma cell line, B104, possesses characteristics that make it an attractive model...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The food ingestion consequences due to radioactive particulates of an accidental release, scenario 1-RD-3, are evaluated for Savannah River Technology Center. The sizes of land areas requiring the protective action of food interdiction are calculated. The consequences of the particulate portion of the release are evaluated with the HOTSPOT model and an EXCEL spreadsheet for particulates.

UK PubMed Central (United Kingdom)

G protein-coupled receptors (GPCRs) are known to modulate intracellular effectors involved in cardiac function. We recently reported homocysteine (Hcy)-induced ERK-phosphorylation was suppressed...Full Text Available

UK PubMed Central (United Kingdom)

Growth differentiation factor-9 (GDF-9), an oocyte-secreted member of the transforming growth factor β superfamily, progesterone receptor, cyclooxygenase 2 (Cox2; Ptgs2), and the EP2 prostaglandin...Full Text Available

UK PubMed Central (United Kingdom)

The expression status of the estrogen receptor alpha (ERα) and that of the epidermal growth factor receptor Her-2/neu frequently correlate inversely in breast cancers. While ERα-dependent...Full Text Available

UK PubMed Central (United Kingdom)

Synthesis of the Streptococcus pneumoniae type 3 capsule requires the pathway glucose-6-phosphate (Glc-6-P) → Glc-1-P → UDP-Glc → UDP-glucuronic acid (UDP-GlcUA)...Full Text Available

UK PubMed Central (United Kingdom)

Cyclin-Dependent Kinase 1 (CDK1) is the major M-phase kinase known also as the M-phase Promoting Factor or MPF. Studies performed during the last decade have shown many details of how CDK1 is regulated...Full Text Available

UK PubMed Central (United Kingdom)

Surveys of the antigenic properties of a wide range of variants of the H3N2 (Hong Kong) influenza virus subtype have revealed complex patterns of variants cocirculating during each of the main epidemic...Full Text Available

UK PubMed Central (United Kingdom)

Arsenic trioxide (As₂O₃), used to treat promyelocytic leukemia, triggers cell death via unknown mechanisms. To further our understanding of As₂O₃-induced...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

One approach to validate nuclear power plant (NPP) signals makes use of pattern recognition techniques. This approach often assumes that there is a set of signal prototypes that are continuously compared with the actual sensor signals. These signal prototypes are often computed based on empirical models with little or no knowledge about physical processes. A common problem of all data-based models is their limited ability to make predictions on the basis of available training data. Another problem is related to suboptimal training algorithms. Both of these potential shortcomings with conventional approaches to signal validation and sensor operability validation are successfully resolved by adopting a recently proposed learning paradigm called the support vector machine (SVM). The work presented here is a novel application of SVM for data-based modeling of system state variables in an NPP, integrated with a nonlinear, nonparametric technique ...

CERN Document Server

Mining patterns from multi-relational data is a problem attracting increasing interest within the data mining community. Traditional data mining approaches are typically developed for highly simplified types of data, such as an attribute-value table or a binary database, such that those methods are not directly applicable to multi-relational data. Nevertheless, multi-relational data is a more truthful and therefore often also a more powerful representation of reality. Mining patterns of a suitably expressive syntax directly from this representation, is thus a research problem of great importance. In this paper we introduce a novel approach to mining patterns in multi-relational data. We propose a new syntax for multi-relational patterns as complete connected subgraphs in a representation of the database as a K-partite graph. We show how this pattern syntax is generally applicable to multirelational data, while it reduces to well-known tiles [7] ...

International Nuclear Information System (INIS)

As a three-year joint university-industry effort, development of a generalized boiling transition analysis method has been started in 2002 aiming at enhanced capabilities of subchannel analysis for a wide variety of BWR-type fuel bundle geometry from ordinary BWR to tight lattice fuel bundles. For this purpose, five dominant factors affecting boiling transition phenomena have been identified on which our efforts of experimentation and numerical analyses are focused. In this report, as the first-year achievement, we will describe a master plan of the development and contents for experimental approaches to construct thermal-hydraulic databases. The databases will be utilized for the developments of constitutive equations to describe the basic characteristics of the elementary processes. The planned experiments are divided into two groups. One is air-water experiments at atmospheric pressure, and the other is steam-water experiments up to 1 MPa. ...

International Nuclear Information System (INIS)

There are about 440 operating nuclear power reactors in the world including 20 units from Korea. The average age of the reactors is more than 20 years and many of them are approaching to their original 30 or 40 years licensing terms. Even though some failures were reported in components or pipes of nuclear power plants (NPPs), these NPPs are considered to be too valuable to stop their operation at the end of design life. Therefore, the long-term operation of NPPs has become a worldwide trend based on technical and economic consideration. In order to ensure safe long-term operation of NPPs, it is increasingly necessary to adopt new approaches to deal with nuclear materials aging and degradation. Proactive Material Degradation Assessment (PMDA) is one of the key elements of these new approaches. Many kinds of background information such as materials and degradation history of components or piping in NPP plant are also needed for PMDA by the experts. Nuclear Materials and Degradation ...

International Nuclear Information System (INIS)

The Transportation Legislative Database (TLDB) is an on-line information service containing detailed information on legislation and regulations regarding the transportation of radioactive materials in the United States. The system is dedicated to serving the legislative and regulatory information needs of the US Department of Energy and other federal agencies; state, tribal, and local governments; the hazardous materials transportation industry; and interested members of the general public. In addition to the on-line information service, quarterly and annual Legal Developments Reports are produced using information from the TLDB. These reports summarize important changes in federal and state legislation, regulations, administrative agency rulings, and judicial decisions over the reporting period. Information on significant legal developments at the tribal and local levels is also included on an as-available basis. Battelle's Office of Transportation Systems and ...

CERN Document Server

Association rule mining aims to explore large transaction databases for association rules. Classical Association Rule Mining (ARM) model assumes that all items have the same significance without taking their weight into account. It also ignores the difference between the transactions and importance of each and every itemsets. But, the Weighted Association Rule Mining (WARM) does not work on databases with only binary attributes. It makes use of the importance of each itemset and transaction. WARM requires each item to be given weight to reflect their importance to the user. The weights may correspond to special promotions on some products, or the profitability of different items. This research work first focused on a weight assignment based on a directed graph where nodes denote items and links represent association rules. A generalized version of HITS is applied to the graph to rank the items, where all nodes and links are allowed to have ...

CERN Document Server

This paper reports on the detection of optical novae in our neighbour galaxy M31 based on digitized historical Tautenburg Schmidt plates. The accurate positions of the detected novae lead to a much larger database for searches for recurrent novae in M31. We conducted a systematic search for novae on 306 digitized Tautenburg Schmidt plates covering a time span of 36 years from 1960 to 1996. From the database of both ~ 300 000 light curves and about one million detections on only one plate per colour band, nova candidates were efficiently selected by automated algorithms and subsequently individually inspected by eye. We report the detection of 84 nova candidates. In detail we found 55 nova candidates from the automated analysis of the light curves. Among these, 22 were previously unknown, 12 were known but have not been identified on Tautenburg Schmidt plates before and 21 novae have been discovered on Tautenburg plates previously. An additional ...

Energy Technology Data Exchange (ETDEWEB)

The onshore Potiguar basin has nowadays around 5.000 artificial lifting petroleum wells, distributed into 80 fields located on the states of Rio Grande do Norte and Ceara, representing approximately 8% of the national oil production. For that, well maintenance service, realized by Workover Rigs, is essential to preserve the oil productivity of the reservoirs on these fields. However, as the number of rigs is lower than to the number of wells needing maintenance, the task of administrating the management of such equipment according to the demand created by the wells, generates an optimization problem. The decision for a rig intervention on a well depends on parameters such as flow rate, depth, wasted time on intervention, distance from the rig to the next well, type of operation, rig capacity, environmental risks, etc. The objective of this paper is to present an interactive Computational System for Support Decision to the optimized management of the wells attended by the rig fleet. ...

CERN Document Server

Similarity searching finds application in a wide variety of domains including multilingual databases, computational biology, pattern recognition and text retrieval. Similarity is measured in terms of a distance function edit distance in general metric spaces, which is expensive to compute. Indexing techniques can be used reduce the number of distance computations. We present an analysis of various existing similarity indexing structures for the same. The performance obtained using the index structures studied was found to be unsatisfactory . We propose an indexing technique that combines the features of clustering with M tree(MTB) and the results indicate that this gives better performance.

Energy Technology Data Exchange (ETDEWEB)

The bibliography contains citations concerning the recycling of scrap plastic produced in the injection molding process. Plastic pellets made from scrap, that are used in the injection molding process, are also discussed. Recycling equipment and automated recycling systems are described. The reuse of plastic scrap culled from junk automobiles and packaging materials is discussed, and waste byproducts from polyurethane production are described. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

Energy Technology Data Exchange (ETDEWEB)

This conference provided a forum to discuss advances in the application of bioengineering principles and practices dealing with biological systems for the production of food, bioproducts and energy. The topics of discussion ranged from engineering practices in agriculture, forestry, bioresources, biochemistry and biosystems. The sessions of the conference were entitled: renewable energy; waste management; soil and water; machinery systems; building and storage systems; and bioproducts and food. The conference also featured a workshop on integrated biomass supply and logistics. In addition to 20 posters, the conference featured 67 presentations, of which 3 have been catalogued separately for inclusion in this database. refs., tabs., figs.

Energy Technology Data Exchange (ETDEWEB)

The bibliography contains citations concerning plasma immersion ion implantation (PIII) and equipment. PIII is a new technique to implant plasma ions into materials for surface modification and treatment. Topics include plasma nitriding, semiconductor doping, ion energy distribution, ion dose, pulsed plasma, metal plasma, and defect passivation. References also review applications in semiconductor device and integrated circuit manufacture, silicon material fabrication, aerospace bearings, carbon coatings on metals, and ceramic coatings. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

Energy Technology Data Exchange (ETDEWEB)

The bibliography contains citations concerning the pitting corrosion of copper and copper alloys by different media, with some references to methods that protect against such corrosion. Included are factors contributing to the onset of pitting corrosion. Emphasis is placed on exposure to water, especially in heat exchanger tubing and water conduits. Studies are included which examine corrosion in metals containing small amonts of copper where corrosion is attributable to changes in alloying. (Contains a minimum of 158 citations and includes a subject term index and title list.)

Energy Technology Data Exchange (ETDEWEB)

The primary goal of this project is to increase the availability and ease of access to critical data on the Mesaverde and Dakota tight gas reservoirs of the San Juan Basin. Secondary goals include tuning well log interpretations through integration of core, water chemistry and production analysis data to help identify bypassed pay zones; increased knowledge of permeability ratios and how they affect well drainage and thus infill drilling plans; improved time-depth correlations through regional mapping of sonic logs; and improved understanding of the variability of formation waters within the basin through spatial analysis of water chemistry data. The project will collect, integrate, and analyze a variety of petrophysical and well data concerning the Mesaverde and Dakota reservoirs of the San Juan Basin, with particular emphasis on data available in the areas defined as tight gas areas for purpose of FERC. A relational, geo-referenced database (a geographic ...

International Nuclear Information System (INIS)

This paper discusses key methods for sustaining quality engineering data, the fundamental principles that these methods are based on, and the methods for supporting the performance of nuclear power plants by the provision of quality engineering data at all times. The concept of an 'engineering data foundation', and a Configuration Management data model are developed. The concepts and methods for managing the integrity of engineering data across many different databases and document systems are developed, including the key concepts of data-positions and data-values, Master Data and Copy Data, and the concept of a 'partnership between people and technology'. (author). 7 refs., 1 tab., 2 figs.

Energy Technology Data Exchange (ETDEWEB)

In this handbook, technical reports on a number of hydro plants under construction are provided. In addition tables of compiled data are presented on a world-wide basis for the following: turbine and hydro generator contracts; hydropower resource potential and development; pumped storage plants; the major dams and hydro plants; roller compacted concrete dams and concrete faced rockfill dams; small hydropower. An address database of international organizations of relevance to hydropower development, national power authorities and nation committees of the International Commission an Large Dams is included. A final and major section of the handbook is a buyer's guide providing extensive company data and information on products and services. (UK)

Energy Technology Data Exchange (ETDEWEB)

This forum provided insights into Ontario's new smart meter program. Challenges related to implementing the smart meter program were reviewed, and various functional and operational considerations of the meters were considered. The implications and benefits of using real time metering systems were discussed along with issues related to energy conservation and demand management. Various communications technologies were considered in relation to smart metering program implementation. Issues related to pricing and pricing policies were also discussed. The conference featured 11 presentations, of which 2 have been catalogued separately for inclusion in this database. refs., tabs., figs.

British Library Electronic Table of Contents (United Kingdom)

Abstract Introduction: The obstructed, infected kidney is a urological emergency. It has been accepted that the management of infected hydronephrosis secondary to ureteric stones is through prompt decompression of the collecting system. However, the optimal method of decompression has yet to be established. Materials and Methods: A PubMed and Medline search was performed of all English-language articles from 1960 using key words ?sepsis,?? ?urosepsis,?? ?obstruction,?? ?obstructive pyelonephritis,?? ?pyonephrosis,?? ?infection and hydronephrosis?? ?decompression,?? ?stent,?? ?nephrostomy,?? and ?management.?? The Cochrane database and National Institute for Clinical Effectiveness guidelines were searched using the terms ?sepsis,?? ?urosepsis,?? ?stent,?? ?nephrostomy,?? or ?obstruction.?? ...

CERN Document Server

Technology progress in DNA sequencing boosts the genomic database growth at faster and faster rate. Compression, accompanied with random access capabilities, is the key to maintain those huge amounts of data. In this paper we present an LZ77-style compression scheme for relative compression of multiple genomes of the same species. While the solution bears similarity to known algorithms, it offers significantly higher compression ratios at compression speed over a order of magnitude greater. One of the new successful ideas is augmenting the reference sequence with phrases from the other sequences, making more LZ-matches available.

Energy Technology Data Exchange (ETDEWEB)

The term "homology" or "homologous" means an amino acid similarity measured by the program, BLAST (Altschul et al (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:33 89 3402), and expressed as --(% identity n/n). In measuring homology between a peptide and a protein of greater size, homology is measured only in the corresponding region; that is, the protein is regarded as only having the same general length as the peptide, allowing for gaps and insertions.

Energy Technology Data Exchange (ETDEWEB)

The authors evaluated three of the top man-machine interface (MMI) software systems. The main categories upon which they based their evaluation on were the following: operator interface; network and data distribution; input/output (I/O) interface; application development; alarms; real-time and historical trending; support, documentation, and training; processing tools (batch, recipe, logic); reports; custom interfacing; start-up/recovery; external database; and multimedia. They also present their MMI requirements and guidelines for the selection and evaluation of these MMI systems.

CERN Document Server

We develop methods for accelerating metric similarity search that are effective on modern hardware. Our algorithms factor into easily parallelizable components, making them simple to deploy and efficient on multicore CPUs and GPUs. Despite the simple structure of our algorithms, their search performance is provably sublinear in the size of the database, with a factor dependent only on its intrinsic dimensionality. We demonstrate that our methods provide substantial speedups on a range of datasets and hardware platforms. In particular, we present results on a 48-core server machine, on graphics hardware, and on a multicore desktop.

Energy Technology Data Exchange (ETDEWEB)

The DOETRAN model is a DSM database manager, developed to act as an intermediary between the whole building energy simulation model, DOE-2, and the DBEDT DSM Forecasting Model. DOETRAN accepts output data from DOE-2 and TRANslates that into the format required by the forecasting model. DOETRAN operates in the Windows environment and was developed using the relational database management software, Paradox 5.0 for Windows. It is not necessary to have any knowledge of Paradox to use DOETRAN. DOETRAN utilizes the powerful database manager capabilities of Paradox through a series of customized user-friendly windows displaying buttons and menus with simple and clear functions. The DOETRAN model performs three basic functions, with an optional fourth. The first function is to configure the user`s computer for DOETRAN. The second function is to import DOE-2 files with energy and loadshape data for each building type. The third main ...

Energy Technology Data Exchange (ETDEWEB)

A new opportunity to improve the safety and efficiency of environmental restoration operations, using robotics has emerged from advances in industry, academia, and government labs. Self-Guided Vehicles (SGV`s) have recently been developed in industry and early systems have already demonstrated much, though not all, of the functionality necessary to support driverless transportation of waste within and between processing facilities. Improved materials databases are being developed by at least two DOE remediation sites, the Fernald Environmental Management Project (FEME) in the State of Ohio and the Hanford Complex in the State of Washington. SGV`s can be developed that take advantage of the information in these databases and yield improved dispatch, waste tracking, report and shipment documentation. In addition, they will reduce the radiation hazard to workers and the risk of damaging containers through accidental collision. In this document, ...