The Monte Carlo transport codes LAHET and MCNP were used to calculate energy fluence spectra at three neutrontherapy facilities. The results compare very favourably with measured data. Kerma spectra and the ratio of ICRU muscle tissue kerma to A-150 kerma, along the carbon to oxygen kerma ratio, were determined. Absorbed dose rate calculations are in reasonable agreement with measured values. Use of these codes to study modifications to existing therapy beams is briefly discussed. (author).
Several compact proton accelerator systems for use in proton therapy have recently been proposed. Of paramount importance to the development of such an accelerator system is the maximum kinetic energy...Full Text Available
In clinical applications, it is very important to accurately determine the range of a proton beam in a patient. Recently, a prototype prompt-gamma scanning system, called a prompt-gamma scanner (PGS), has been constructed at Hanyang University in Korea with the collaboration of the Korean national cancer center (NCC), based on a series of Monte Carlo simulations. The PGS system is composed of a prompt-gamma collimator, a CsI(Tl) scintillation detector, a multi-channel analyzer (MCA), a precision movement system, and an integrated readout system. The prompt-gamma collimator is designed to effectively shield high-energy neutrons from the proton beam passage and subsequent capture gammas. The PGS system can be used to scan the distribution of the prompt gammas in the patient from the proton beam passage. The distribution of the prompt gammas can then be used to determine the proton beam range or the distal dose edge in the patient. In this study, the PGS system was ...
Optimal neutron energy for boron neutron capture therapy (BNCT) has been studied. Epithermal neutron is superior to thermal neutrons in treating deep-seated tumors. Design of the epithermal neutron column for BNCT has been performed by using a two-dimensional transport calculation code. Aluminum and heavy water are used as moderation materials. A thermal neutron column is also designed using heavy water as thermalization material. The configuration of the facility for treatment and research of BNCT and also for basic radio-biological studies of neutrons has been presented.
Optimal neutron energy for boron neutron capture therapy (BNCT) has been studied. Epithermal neutron is superior to thermal neutrons in treating deep-seated tumors. Design of the epithermal neutron column for BNCT has been performed by using a two-dimensional transport calculation code. Aluminum and heavy water are used as moderation materials. A thermal neutron column is also designed using heavy water as thermalization material. The configuration of the facility for treatment and research of BNCT and also for basic radio-biological studies of neutrons has been presented. (author).
This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.
This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.
Several configurations of moderating and shielding materials have been designed and measured on the LVR-15 reactor for boron neutron capture therapy (BNCT) purposes. To determine the neutron and gamma ray space-energy distributions in the cylindrical geometry, the two-dimensional code DOT with the coupled neutron-gamma data library DLC-36 was used. The experimental verification of the beam parameters was performed in the LVR-15 reactor thermal column empty space with layers of graphite, aluminium, alumina, lead and bismuth. Attention was paid to establishing techniques and instrumentation for monitoring the neutron and gamma ray dose and beam quality. The thermal and epithermal flux densities were measured by activation foils, the neutron spectrum was determined with a Bonner spectrometer and gamma ray background with a scintillation spectrometer. The ...
Several configurations of moderating and shielding materials have been designed and measured on the LVR-15 reactor for boron neutron capture therapy (BNCT) purposes. To determine the neutron and gamma ray space-energy distributions in the cylindrical geometry, the two-dimensional code DOT with the coupled neutron-gamma data library DLC-36 was used. The experimental verification of the beam parameters was performed in the LVR-15 reactor thermal column empty space with layers of graphite, aluminium, alumina, lead and bismuth. Attention was paid to establishing techniques and instrumentation for monitoring the neutron and gamma ray dose and beam quality. The thermal and epithermal flux densities were measured by activation foils, the neutron spectrum was determined with a Bonner spectrometer and gamma ray background with a scintillation spectrometer. The ...
The research on the therapy of brain tumors and others by the thermal neutron irradiation using research reactors is to kill tumor cells by accumulating boron at a tumor part, and using {alpha} particles and {sup 7}Li generated by {sup 10}B(n, {alpha}){sup 7}Li reaction of thermal neutrons, which is known as boron neutron capture therapy (BNCT). In Japan Atomic Energy Research Institute, the medical irradiation facility was installed in the thermal neutron column of the JRR-2, and as of March, 1994, 22 cases of irradiation have been carried out. In order to monitor the variation of thermal neutron flux during irradiation, the real time measurement using a simultaneous monitor is carried out, but there is the variation of measured values in the Si semiconductor, p-n junction detector possibly due to its direction dependence. The experiment ...
This report is a summary of the progress and research produced for the Idaho National Engineering and Environmental Laboratory (INEEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1996. Contributions from the individual investigators about their projects are included, specifically, physics: treatment planning software, real-time neutron beam measurement dosimetry, measurement of the Finnish research reactor epithermal neutron spectrum, BNCT accelerator technology; and chemistry: analysis of biological samples and preparation of {sup 10}B enriched decaborane.
A computer-based beam dosimetry measurement system for boron neutron capture therapy provides accurate, sensitive, and rapid readout and recording of all beam dose components, epithermal and thermal neutron flux, and gamma-ray dose rate. This dosimetric system includes input from the characterization of the epithermal neutron beam developed at the Massachusetts Institute of Technology, actual BPA pharmacokinetic data from a specific human subject being irradiated, output of MacNCTPLAN, a treatment planning system developed by the authors group, and input from the five on-line beam detectors. The purpose of this system and associated readout systems is to ensure that the desired dose is delivered to the subject within acceptable dose tolerances, e.g., {+-}5% of the target dose, and that any perturbations in the neutron beam that may occur during irradiation can be rapidly evaluated ...
A computer-based beam dosimetry measurement system for boron neutron capture therapy provides accurate, sensitive, and rapid readout and recording of all beam dose components, epithermal and thermal neutron flux, and gamma-ray dose rate. This dosimetric system includes input from the characterization of the epithermal neutron beam developed at the Massachusetts Institute of Technology, actual BPA pharmacokinetic data from a specific human subject being irradiated, output of MacNCTPLAN, a treatment planning system developed by the authors group, and input from the five on-line beam detectors. The purpose of this system and associated readout systems is to ensure that the desired dose is delivered to the subject within acceptable dose tolerances, e.g., #+-#5% of the target dose, and that any perturbations in the neutron beam that may occur during irradiation can be rapidly evaluated ...
Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer cells in the brain. Upon neutron capture by {sup 10}B energetic alpha particles and triton released at the absorption site kill the cancer cell. In order to gain penetration depth in the brain Fairchild proposed, for this purpose, the use of energetic epithermal neutrons at about 10 keV. Phase I/II clinical trials of BNCT for GM are underway at the Brookhaven Medical Research Reactor (BMRR) and at the MIT Reactor, using these nuclear reactors as the source for epithermal neutrons. In light of the limitations of new reactor installations, e.g. cost, safety and licensing, and limited capability for modulating the reactor based ...
A discussion is presented of the 750-KeV chopper experience with both proton and negative ion beams and the ability of these systems to tailor the Linac beam to the diverse requirements of its users; normal accelerator injection, neutrontherapy beam, and electron cooling experiments. This flexibility plus a cleaner beam pulse, improved thyratron operation, and mechanical modularity are the results of recent improvements. Additional benefits have been increased reliability and ease of service to the 750-KeV chopper. 3 refs.
Boron neutron capture therapy (BNCT) trials for human glioma (glioblastoma multiform) were initiated September 1994 at the Brookhaven National Laboratory (BNL). Patients are given p-boronophenylalanine-fructose (BPA-F) intravenously as the boron carrier followed by exposure to the epithermal-neutron beam at the Brookhaven Medical Research Reactor (BMRR). The initial phase of the study is to determine safety and toxicity of the drug and irradiation procedure. The epithermal-neutron beam was developed in a joint effort by BNL and Idaho National Engineering Laboratory (INEL) researchers. For the human trials, treatment planning and radiation dose estimation is performed using the BNCT-Rtpe and the rtt-MC computer codes developed by the INEL BNCT program. This paper discusses our initial experience using these treatment planning codes for human subjects. The basic principles of BNCT have been previously ...
Early effects of boron neutron capture therapy (BNCT) on malignant glioma are characterized by reduction of the enhancement area and regression of the peritumoral edema radiologically. The aim of this study was to investigate the early histological changes of tumors and inflammatory cells after BNCT in the rat brain. Rats were treated with BNCT using boronophenylalanine (BPA) 7 days after implantation of C6 glioma cells. The tumors were assessed with magnetic resonance imaging and histopathological examination at 4 days after BNCT. The mean tumor volumes were 39#+-#2 mm"3 in the BNCT group and 134#+-#18 mm"3 in the control group. In the BNCT group, tumor cells showed a less pleomorphic appearance with atypical nuclei and mitotic figures. The Ki-67 labeling index was 6.5%#+-#4.7% in the BNCT and 35%#+-#3.8% in the control group. The reactions of the inflammatory cells were examined with ED-1 as macrophage marker and OX42 as microglia marker. ...
The proton beam has an advantage of the sharp dose falloff in dose distribution called Bragg peak while conventional radiation therapy modalities such as photons exhibit considerable amount of exit dose. To take advantage of this property it is important to know the exact location of the distal dose falloff. An error can cause overdose to the normal tissue or underdose to the tumor volume. The only way of finding out the dose distribution in-situ in particle therapy is to measure the gammas produced by nuclear reactions with tissue materials. Two kinds of gammas can be used: one is prompt gamma and the other is coincident gamma from the positron-emission isotopes. We chose to detect prompt gammas, and developed a prompt gamma scanning system (PGS). The proton beams of the proton therapy facility at National Cancer Center were used. The gamma distribution was compared to the dose distribution measured by an ionization ...
A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2 h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4 h post PBAD-lipiodol injection.
... or she will start intensive rehabilitation. This includes physical therapy and occupational therapy. Physical and occupational therapies aim at strengthening the remaining ...
The Plasma and Ion Source Technology Group at the Lawrence Berkeley National Laboratory have been developing rf-driven ion sources for the last two decades. These sources are being used to generate both positive and negative ion beams. Some of these sources are operating in particle accelerators such as the Spallation Neutron Source (SNS) at Oak Ridge, while others are being employed in various industrial ion beam systems. There are four areas where the rf-driven ion sources are commonly used in industry. (1) In semiconductor manufacturing, rf-driven sources have found important applications in plasma etching, ion beam implantation, and ion beam lithography. (2) In material analysis and surface modification, miniature rf-ion sources can be found in focused ion beam systems. They can provide ion beams of essentially any element in the Periodic Table. The newly developed combined rf ion-electron beam unit improves greatly the performance of the secondary ion mass ...
LECTURE SERIES 14, 15, 17 January 2008 11:00 to 12:00 - Council Chamber, bldg. 503-1-001 Applications of accelerators to tumour therapy U. AMALDI, TERA Foundation & University of Milano Bicocca The first lecture is devoted to an historical review of the developments of the teletherapy techniques which make use of hadron beams and are collectively called "hadrontherapy". The main emphasis is on the use of protons and light ions, but also neutrons, pions and antiprotons are considered. The second lecture reviews the rationale behind the use of carbon ions in the treatment of radioresistant tumours and the results obtained both with proton and carbon ion beams on the 60 000 patients treated worldwide. The numbers of patients who would profit from hadrontherapy are presented together with the current landscape of running and planned hospital based centres. The main technical challenges set by this therapeutic modality are discussed in the ...
Abstract The authors provide a survey of how images are used in radiation therapy to improve the precision of radiation therapy plans, and delivery of radiation treatment. In contrast...Full Text Available
The incidence of hilar cholangiocarcinoma is very rare worldwide. Radical resection is the only prognostic factor for long survival in patients with hilar cholangiocarcinoma. Postoperative radiation therapy can improve local control and survival rates for patients with palliative resection, but it remains controversial in patients with radical resection. Biliary drainage can effectively release bile duct obstruction for the majority of patients with locally advanced disease, and may even prolong survival when combined with radiation therapy. Radiation therapy includes extrernal beam therapy alone, external beam therapy with intraluminal brachytheapy and new radiation technique, such as three dimentional conformal therapy and intensity modulated radiation therapy. The propective randomized clinical study is needed for further investigation in ...
Beams may be viewed as directed and focussed flow of energy and information, carried by particles and electromagnetic radiation fields (ie, photons). Often, they interact with each other (eg, in high energy colliders) or with other forms of matter (eg, in fixed targets, sychrotron radiation, neutron scattering, laser chemistry/physics, medical therapy, etc.). The whole art and science of beams revolve around the fundamental quest for, and ultimate implementation of, mechanisms of production, storage, control and observation of beams -- always directed towards studies of the basic structures and processes of the natural world and various practical applications. Tremendous progress has been made in all aspects of beam physics and technology in the last decades -- nonlinear dynamics, superconducting magnets and rf cavities, beam instrumentation and control, novel concepts and collider praradigms, to name a few. We illustrate this progress with a ...
BackgroundTransarterial chemoembolization (TACE) therapy is an effective locoregional treatment in hepatocellular cancer (HCC) patients. For early modification of therapy, markers...Full Text Available
Forty-four patients with histologically proven Hodgkin's disease underwent initial treatment with extended-field radiation therapy. Nineteen of these patients also received combination chemotherapy....Full Text Available
The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy...Full Text Available
Radionuclide bone metastases therapy is a major achievement of nuclear medicine. Development of less radiotoxic and more effective radiopharmaceuticals is therefore a challenge for radiopharmacists and industry. This paper reviews the application of rhenium-188 HEDP as a reactor- or generator-produced nuclide for bone metastases therapy. (author)
The current therapy for extrinsic and intrinsic asthma, together with that of ‘wheezing bronchitis’, is presented, with special attention to bronchodilators and adrenocorticosteroids....Full Text Available
The eye is an easily accessible, highly compartmentalised and immune-privileged organ that offers unique advantages as a gene therapy target. Significant advancements have been made in understanding...Full Text Available
PurposeTo determine the dosimetric impact of inter-fraction anatomical movements in prostate cancer patients receiving proton therapy.Full Text Available
1 Recommendations for correct therapy with digoxin from twenty-five sources are reviewed. 2 Some recommendations may be unsuitable for use with high bioavailability...Full Text Available
... radiation during clinical therapy and exposures due to radiation accidents or attacks, in which the doses are uncontrolled ... only be used off-label in victims of radiation accidents or attacks. The idea...
Radiation therapy has shown definite technical improvement due to application of proton beam irradiation. Clinical results of proton beam therapy also suggested enlargement of indication ranges in radial treatment and decrease of post radiation damages of the treatment of cancers in deep-seated organs. Inprovement of result in cancer therapy could be expected by this treatment technique in the future.
BackgroundTo compare two strategies of dynamic intensity modulated radiation therapy (dIMRT) with 3-dimensional conformal radiation therapy (3DCRT) in the setting of hypofractionated...Full Text Available
Radiotherapy can be very significant as the treatment for ocular lesions, eyes need to be preserved as properly as possible on their functions and cosmetics. The application of conventional X ray therapy has been gradually abandoned as conventional X ray therapy ceased to be accepted as the general treatment for malignant tumors. Consequently the necessity of electron beam therapy has been rising even as the substituted method for conventional X ray therapy. The department of radiology of Gunma University was obliged to establish a new therapy for ocular lesions, and has been trying electron beam therapy since 1973. It is concluded that electron beam therapy is not at all inferior to conventional X ray therapy as reported above. Basic therapeutic methods for ocular lesions are the following: 1) For epidermoid carcinoma, ...
Neutron radiography and neutron radioscopy are rapidly becoming the valuable tools for nondestructive testing and basic research. The Phoenix Memorial Laboratory has developed a neutron facility capable of both film neutron radiography and real time neutron radioscopy, and has used this facility to study several phenomena of interest to the researchers in many areas. Neutrons can be used for imaging the phenomena that X-ray cannot image, such as the presence, absence or movement of hydrogenous materials inside metals such as aluminum or steel. There are three basic methods for obtaining images using neutrons: high resolution film neutron radiography, real-time neutron radioscopy and transfer film neutron radiography. The neutron radiography facility at ...
The authors have developed a high-sensitivity real-time neutron radiography (NR) system by the use of the low power reactor of Kinki University. The system was constructed with a high efficiency neutron-photon converter, an image intensifier and a SIT TELEVISION camera. Some digital image processing techniques were applied for improving the quality of the real-time neutron images. By the use of this system, dynamic neutron imaging was performed successfully under the condition of a weak neutron field that was about two orders of magnitude lower than that of the standard NR system. The neutron flux, calculated from the fluctuation of the neutron response of the images, was nearly equal to the value measured by the foil activation method. From this fact, the efficiency for the neutron detection of the imaging system was ...
The authors have developed a high-sensitivity real-time neutron radiography (NR) system by the use of the low power reactor of Kinki University. The system was constructed with a high efficiency neutron-photon converter, an image intensifier and a SIT TELEVISION camera. Some digital image processing techniques were applied for improving the quality of the real-time neutron images. By the use of this system, dynamic neutron imaging was performed successfully under the condition of a weak neutron field that was about two orders of magnitude lower than that of the standard NR system. The neutron flux, calculated from the fluctuation of the neutron response of the images, was nearly equal to the value measured by the foil activation method. From this fact, the efficiency for the neutron detection of the imaging system was ...
Presented are results of a test of a method for measuring neutron fluences using detectors with fissionable nuclides. The investigations show the soundness of of using neutron-activation detectors of the type Am for mesurements in nuclear installations for values of thermal-neutron fluence of from 10/sup 13/ to 10/sup 20/ neutrons/cm/sup 2/ with exposure for up to several months. The proposed method can be used for prolonged measurements in strong fields of both thermal and fast neutrons.
This report discusses the following topics: Prompt fission neutron energy spectra for {sup 235}U and {sup 239}Pu; Two-parameter measurement of nuclear lifetimes; ``Black`` neutron detector; Data reduction techniques for neutron scattering experiments; Inelastic neutron scattering studies in {sup 197}Au; Elastic and inelastic scattering studies in {sup 239}Pu; and neutron induced defects in silicon dioxide MOS structures.
Following a recent refurbishment of the NPL Thermal Neutron Facility, the spectrum of the epithermal and fast neutron component of the beam produced by the thermal column of this facility was measured over the energy range from thermal to 20 MeV using a Bonner sphere spectrometry system. The effect of the presence of epithermal and fast neutrons on the measured response of commonly-used thermal neutron dosemeters was calculated. (author)
Following a recent refurbishment of the NPL Thermal Neutron Facility, the spectrum of the epithermal and fast neutron component of the beam produced by the thermal column of this facility was measured over the energy range from thermal to 20 MeV using a Bonner sphere spectrometry system. The effect of the presence of epithermal and fast neutrons on the measured response of commonly-used thermal neutron dosemeters was calculated. (author)
The side effects of cancer therapy on normal tissues limit the success of therapy. Generation of reactive oxygen species (ROS) has been implicated for numerous chemotherapeutic agents including doxorubicin...Full Text Available
BackgroundIt remains unclear if certain antiretroviral medications, particularly abacavir, compromise response to hepatitis C virus (HCV) therapy. Such data can inform...Full Text Available
BackgroundAdolescents have been identified as a high-risk group for poor adherence to and defaulting from combination antiretroviral therapy (cART) care. However, data on outcomes...Full Text Available
A simple device is described which is used to determine treatment distance and beam direction in electron therapy employing one collimation. A technique for the production of irregular field templates and localization films is given.
ObjectivesTo investigate the effect of group cognitive behavioural therapy (CBT) for fatigue self-management, compared with groups receiving fatigue information alone, on fatigue...Full Text Available
BackgroundTo assess the relationship between improved regional and global myocardial function in patients with ischemic cardiomyopathy in response to β-blocker therapy or...Full Text Available
Current adherence assessments typically detect missed doses long after they occur. Real-time, wireless monitoring strategies for antiretroviral therapy may provide novel opportunities to proactively...Full Text Available
Epidermal growth factor receptor (EGFR) related therapies – mainly tyrosine kinase inhibitors (TKIs) such as erlotinib and gefitinib, but also monoclonal antibodies targeting EGFR, for example,...Full Text Available
BackgroundThe aim of this study was to compare and to validate different dose calculation algorithms for the use in radiation therapy of small lung lesions and to optimize the treatment...Full Text Available
BackgroundThe lack of adequate randomized clinical trials (RCT) has hindered identification of new therapies that are safe and effective for patients with primary focal segmental...Full Text Available
Adaptive radiation therapy (ART) is the incorporation of daily images in the radiotherapy treatment process so that the treatment plan can be evaluated and modified to maximize the amount of radiation...Full Text Available
Photodynamic therapy (PDT) is an established endoscopic technique for ablating Barrett’s esophagus with high-grade dysplasia or early-stage intraepithelial neoplasia. The most common clinically...Full Text Available
BackgroundArtemisinin-based combination therapy, currently considered the therapy of choice for uncomplicated Plasmodium falciparum malaria in endemic countries,...Full Text Available
The effect of Photofrin-based photodynamic therapy (PDT) and adjuvant treatment with serum vitamin D3-binding protein-derived macrophage-activating factor (DBPMAF) was examined using a mouse SCCVII...Full Text Available
BackgroundHerpes simplex virus (HSV) suppressive therapy reduces genital and plasma HIV-1 RNA over periods up to three months but the longer-term effect is unknown.Full Text Available
Somatic cell nuclear transfer or therapeutic cloning has provided great hope for stem cell-based therapies. However therapeutic cloning has been experiencing both ethical and technical difficulties....Full Text Available
ObjectiveTo evaluate the effect of different concomitant disease modifying antirheumatic drugs (DMARDs) on the persistence with antitumour necrosis factor (anti-TNF) therapies in...Full Text Available
Suppressed IL-12 production and maladaptive immune activation, both of which are ameliorated by successful highly active antiretroviral therapy (HAART), are thought to play important roles in the immunopathogenesis...Full Text Available
Purpose: Understanding the kinetics of tumor growth∕shrinkage represents a critical step in quantitative assessment of therapeutics and realization of adaptive radiation therapy....Full Text Available
Purpose:The risks and benefits of continuing bisphosphonate therapy beyond 5 years in patients with primary osteoporosis have not been well established.Methods:We...Full Text Available
The heterogeneity of metastatic breast cancer mandates the need to select therapies taking into account tumor and patient characteristics. Chemotherapy is indicated in the palliative setting especially...Full Text Available
Some studies suggest that giving radiation therapy after surgery for hilar cholangiocarcinoma improves the survival rate; however, many of these studies did not specify numbers of subjects or provide an impartial analysis. Thus, we evaluated the effectiveness of radiation therapy as adjuvant treatment after surgery and attempted to establish appropriate adaptation standards. We reviewed the records of 69 patients who underwent surgery for hilar cholangiocarcinoma between June 1980 and April 1998. Thirty-nine patients were treated with surgery followed by radiation therapy and 30 were treated with surgery alone. The clinicopathologic features that might have influenced prognosis were similar in the patients who received radiation therapy and those who did not. Radiation as adjuvant therapy did not have a beneficial effect on overall survival (P=0.554, log-rank test); however, it ...
Multiple disease-specific systematic reviews on the effectiveness of physical therapy intervention for shoulder dysfunction have been inconclusive. To date, there have been two systematic reviews that...Full Text Available
IntroductionThe optimal dialysis dose for the treatment of acute kidney injury (AKI) is controversial. We sought to evaluate the relationship between renal replacement therapy (RRT)...Full Text Available
... and at that point she had already failed physical therapy, which someone else had prescribed, and so ... MRI, we may try a brief course of physical therapy to see if they feel better, but ...
PurposeA dosimetric comparison between multiple static-field intensity-modulated radiation therapy (IMRT), multi-arc intensity-modulated arc therapy (IMAT) and single-arc...Full Text Available
ObjectiveTo report the efficacy and safety of combined photodynamic therapy (PDT) and intravitreal bevacizumab (IVB) injection in the treatment of idiopathic polypoidal choroidal...Full Text Available
Premature circuit clotting is a major problem in daily practice of continuous renal replacement therapy (CRRT), increasing blood loss, workload, and costs. Early clotting is related to bioincompatibility,...Full Text Available
This study was an evaluation of the performance of self-applied, blue light, light-emitting diode therapy in the treatment of mild-to-moderate inflammatory acne on the face, concerning: 1) time to improvement...Full Text Available
This joint statement was developed by the CMA and the Canadian Pharmaceutical Association, a national association of pharmacists, and includes the goal of drug therapy, strategies for collaboration...Full Text Available
BackgroundPostnatal glucocorticoid therapy in premature infants diminishes chronic lung disease, but it also increases the risk of hypertension in adulthood. Since glucocorticoid...Full Text Available
Adjuvant therapy aims to prevent outgrowth of residual disease but can induce serious side effects. Weighing conflicting treatment effects and communicating this information with patients is not elementary....Full Text Available
In many radiotherapy clinics, geometric uncertainties in the delivery of 3D conformal radiation therapy and intensity modulated radiation therapy of the prostate are reduced by aligning the...Full Text Available
A neutron imaging system (NIS) has been recently installed at the University of Texas TRIGA reactor facility. The imaging system establishes new capabilities for beam diagnostics at the Texas Cold Neutron Source (TCNS) for real-time neutron radiography (RTNR) and for neutron computed tomography (NCT) research. The NIS will also be used for other research projects. The system consists of two subsystems as follows: (1) Thomson 9-in. neutron image intensifier (NII) tube sensitive to cold, thermal, and epithermal neutrons, (2) image-processing unit consisting of vidicon camera, two high-resolution monitors, image enhancement and measurement processor, and video printer. The NIS is installed at the cold neutron beam of the TCNS for testing and cold neutron beam diagnostics.
The proton therapy gives an irradiation adapted to the shape and the depth of tumors ( eyes, head and neck) with a millimetric, even sub millimetric precision for the ophthalmological tumors. It is equally an excellent tool for the pediatrics tumors. For numerous treatments in France the proton therapy is associated to the photons treatments (x radiation). however, others physical treatments could modulate the medical offer, such thermal therapy or treatments by ultrasonic waves. (N.C.)
An electron accelerator unit is described for electron beam therapy, comprising: a source of an electron beam; means for finally directing at least a portion of the beam to a therapy site, the directing means being mechanically independent of, and electrically isolated from, the source, and having a target area; and means for aligning the source with the directing means, the aligning means comprising means for projecting at least one beam of light from the source toward the target area.
An electron accelerator unit is described for electron beam therapy, comprising: a source of an electron beam; means for finally directing at least a portion of the beam to a therapy site, the directing means being mechanically independent of, and electrically isolated from, the source, and having a target area; and means for aligning the source with the directing means, the aligning means comprising means for projecting at least one beam of light from the source toward the target area.
The anesthetic agents methohexital (Brevital), Innovar, and ketamine (Ketaject) were examined for their effect on seizure duration following electroconvulsive stimulation in a rat model of electroconvulsive therapy (ECT). Compared to unanesthetized control animals, methohexital anesthesia shortened seizure duration by 42%, ketamine anesthesia tended to increase seizure duration, and Innovar anesthesia had no effect on duration of seizures. PMID:7349626
The patient positioning and repositioning control in radiation therapy all along the treatment can be conducted using a variety of X-ray sources and imaging detector devices. The development of image guided radiation therapy techniques leads to more frequent use of this imaging control. In this article we summarize the current methods for measuring the dose delivered by X-ray imaging devices used in radiation therapy, as well as basic proposals to take account of these imaging doses for prescribing, recording and reporting radiation therapy treatment. (authors)
AbstractBackground: So far, infliximab (IFX) therapy for the treatment of Crohn's disease (CD) has generally been guided by clinical symptoms. Data on treatment response as ascertained by endoscopy in IFX therapy are scarce. The aims of this study were to measure the endoscopic response rate during IFX induction and maintenance therapy in luminal CD, and also evaluate the role of endoscopy in monitoring IFX therapy. Methods: Data obtained from 71 patients with active luminal CD and treated with IFX were analyzed retrospectively. The endoscopy findings were scored according to mucosal activity as: 0 (remission), 1-2 (mild), 3-4 (moderate), and 5-6 (severe). A positive endoscopic response was determined by a decrease in score of at least two points and mucosal healing was assigned a score of...
Neutron-induced soft error rates (SER`s) of subhalf-micron CMOS SRAM and Latch circuits were studied both experimentally and analytically to investigate cosmic ray neutron-induced soft errors (SE`s). Because the neutron beam used in the measurement has an energy spectrum similar to that of sea-level atmospheric neutrons, the SER data corresponds to those induced by cosmic ray neutrons. The {alpha}-particle induced SER`s were also measured for comparison with the neutron-induced SER`s. Neutron-induced SE`s occurred in both circuits. On the other hand, {alpha}-induced SE`s occurred in SRAM, but not in the Latch circuit. The measured SER`s agreed with simulated results. The authors discussed the significance of how cosmic ray neutrons affects CMOS circuits at ground level.
Gamma-ray spectrometric analysis was employed to determine the nuclides formed in thorium by neutron irradiation. Thorium sample was irradiated by neutron from a pure thermal neutron field, neutron field of Cd ratio of about 4, and epithermal neutron field, respectively. The former irradiation was carried out in a thermal neutron column provided for medical uses of neutrons, and the latters were done in the F-ring position of TRIGA II research reactor of Musashi Institute of Technology. The gamma-ray spectra were obtained and analyzed by employing a fully automatic gamma-ray analysis system named ''GAMA: giant frog:-SYSTEM'' developped by Musashi Institute of Technology. The formation of Pa-233 (U-233) was discussed quantitatively with respect to the difference of the neutron field. (author).
The detection efficiency of a lithium glass detector was calculated using MCNP code, and the calculation was compared with the published results in Pulsed Sphere Plan. A lithium glass detector of our own was made, and its neutron efficiency was calculated. The calculated neutron efficiency was verified with both pulsed and steady DD neutrons. Characteristics of Neutron response of "6Li detector was discussed. (authors)
This paper reviews the effects of neutron irradiation on thermal and mechanical properties and bulk tritium retention of armour materials (beryllium, tungsten and carbon). For each material, the main properties affected by neutron irradiation are described and the specific tests of neutron irradiated armour materials under thermal shock and disruption conditions are summarized. Based on current knowledge, the expected thermal and structural performance of neutron irradiated armour materials in the ITER plasma facing components are analysed.
A thermal neutron imaging facility for computed tomography and real-time neutron radiography is being developed at the University of Texas at Austin. The TRIGA reactor is a graphite-reflected Mark It pool-type research reactor. The neutron imaging facility will use beam port, which is at one end of a through part. Monte Carlo calculations were used to design the neutron collimator for this facility.
The Albedo Theory was applied in order to develop an one-group algorithm for coupled neutron-gamma shielding calculations. The configuration analyzed consists of multilayered plane systems, where a incident neutron current generates gamma radiation through neutron-gamma reactions. The results obtained by Albedo Method and ANISN code have shown excellent agreement. (author)
Purpose: A retrospective analysis was undertaken to determine the indications for, the efficacy of, and the long-term complications of two courses of total skin electron beam therapy for mycosis fungoides. Methods and Materials: A retrospective analysis of 15 patients with the pathologic diagnosis of mycosis fungoides treated in the Department of Radiation Oncology at Stanford University Medical Center between 1968 and 1990 was performed. All patients received two courses of high-dose electron beam therapy to the skin. The mean dose for the total skin treatment for the first course was 32.6 Gy and 23.4 Gy for the second course of treatment. Results: Following the first course of total skin electron beam therapy, 11 of 15 had a complete response, with a mean duration of 11.6 months. All patients received adjuvant therapies between the first and second courses of high-dose total skin electron beam ...
Little clinical evidence has been provided to show the minimization of radiation resistance of tumors using high linear energy transfer radiation. We therefore investigated the radiobiological and molecular pathological aspects of carbon beam therapy. A total of 27 patients with squamous cell carcinoma (SCC) of the cervix were treated using a carbon beam and 50 control patients with SCC of the cervix using a photon beam. The expression of Ki-67, p53, and p27 proteins before radiotherapy and 5 and 15 days after therapy initiation were investigated using immunohistochemistry. Similar changes were observed in Ki-67 labeling index (LI) and p53 LI during carbon and photon beam therapies. However, for carbon beam therapy, the mean p27 LI significantly decreased from 25.2% before treatment to 18.6% on the 5th day after treatment initiation, followed by a significant increase to 36.1% on the 15th day. In ...
Radiation therapy has had a significant and an expanded role in the management of cancer of the pancreas during the last decade. In particular, for locally advanced disease, radiation therapy has improved the median survival of patients to 1 year. Intraoperative electron beam therapy has been applied to unresectable and resectable pancreatic cancer in an attempt to enhance local control of disease and to improve patient survival. This paper presents a survey of the role of radiation therapy in treatment of cancer of the pancreas, provides information on the radiobiological aspects of this treatment modality and details the physical and dosimetric characteristics of intraoperative radiation therapy with electrons. Presented are the design specifics of an applicator system, central axis beam data, applicator parameters, dose distribution data, shielding, treatment planning and means ...
Radiation therapy has had a significant and an expanded role in the management of cancer of the pancreas during the last decade. In particular, for locally advanced disease, radiation therapy has improved the median survival of patients to 1 year. Intraoperative electron beam therapy has been applied to unresectable and resectable pancreatic cancer in an attempt to enhance local control of disease and to improve patient survival. This paper presents a survey of the role of radiation therapy in treatment of cancer of the pancreas, provides information on the radiobiological aspects of this treatment modality and details the physical and dosimetric characteristics of intraoperative radiation therapy with electrons. Presented are the design specifics of an applicator system, central axis beam data, applicator parameters, dose distribution data, shielding, treatment planning and means ...
A high-purity, intense, fast-neutron source has been developed at our laboratory. We describe two inexpensive, straightforward methods of determining the total number of neutrons produced and we review precautions to be taken in applying these methods. (orig.).
Neutron radiography is a non-destructive test method to examine a material by using the dependency of neutron attenuation on the nuclear characteristics of the atoms composing the object material. There are two categories of neutron radiography; static neutron radiography and dynamic neutron radiography. The static neutron radiography is a technique to observe a standing object by using a camera or a film cassette. The dynamic neutron radiography(DNR) is a technique to observe a moving object usually by using a camera. Depending on the camera frame rate, the dynamic neutron radiography is categorized into the real time neutron radiography(RTNR) and the high speed neutron radiography(HSNR). The frame rate for RTNR is 30 frames/s and that for HSNR is usually more that 500 ...
Neutron radiography is a non-destructive test method to examine a material by using the dependency of neutron attenuation on the nuclear characteristics of the atoms composing the object material. There are two categories of neutron radiography; static neutron radiography and dynamic neutron radiography. The static neutron radiography is a technique to observe a standing object by using a camera or a film cassette. The dynamic neutron radiography(DNR) is a technique to observe a moving object usually by using a camera. Depending on the camera frame rate, the dynamic neutron radiography is categorized into the real time neutron radiography(RTNR) and the high speed neutron radiography(HSNR). The frame rate for RTNR is 30 frames/s and that for HSNR is usually more that 500 ...
Effects associated with the temperature dependence of the level density parameter, a(T), are investigated in connection with neutron evaporation processes. Different approximations, for this temperature dependence, are compared for the case of neutron emission from the compound nucleus /sup 209/Pb.
It is shown that a natural consequence of the binary pulsar's evolution is a neutron star collision. Such a collision is expected to eject neutron-rich matter of an r-process character. Taking reasonable estimates for the number of such events over the history of the galaxy, it may be that they account for all of the r-process nuclei.
A black neutron detector of novel design has been constructed and tested as a neutron flux monitor. The neutron time-of-flight (TOF) technique was used to measure the zero degree neutron spectrum from a subnanosecond pulsed proton beam on a thick metallic lithium target. We describe the detector, discuss the shielding arrangement and electronics, determine the low-energy cut-off. We calculate the efficiency, show spectra and compare measured zero degree differential cross-section of the {sup 7}Li(p, n{sub 0}){sup 7}Be reaction with recommended published cross-sections. (orig.).
Because of limitation on neutron-incident data, it is difficult to obtain global optical model potential for neutrons. In contrast, there are some global optical model potentials for proton in detail. It is interesting to convert the proton-incident global optical potentials into neutron-incident ones. In this study we introduce (N-Z)/A dependent symmetry potential terms into the global proton-incident optical potentials, and then obtain neutron-incident ones. The neutron potentials reproduce total cross sections in an acceptable degree. However, a comparison with potentials proposed by other authors brings about a confused situation in the sign of the symmetry terms. (author).
A method and apparatus for nuclear borehole logging, and in particular, neutron porosity logging, uses a neutron source, and a pair of spaced lithium detectors, preferably Li"6I crystal or Li"6 doped glass, to detect neutrons emitted from a borehole formation being logged. The spectrum developed by the lithium detectors is processed to remove the gamma ray background radiation and the hydrogen absorption peak, thus allowing a more accurate neutron count. A Gaussian curve is fitted to the neutron peak of the spectrum, the curve eliminating the hydrogen absorption peak. The area under this Gaussian curve represents the neutron count. (author).
The introduction prior to series of papers on the application of neutrons for materials science (MS) in this issue starts with a brief summary of neutron scattering research history in Japan; from the individual activity by Motoharu Kimura at RIKEN early around 1940s to those at present era of world leading neutron science facilities of both JRR3 research reactor and JPARC of the largest proton Accelerator complex in Tokai. Then physical properties of low energy neutrons applied to MS as well as such neutron sources are also reviewed (http://www.jstage.jst.go.jp/browse/jvsj2). (author)
Determination of thermal to fast neutron flux ratio (ffast) and fast neutron flux (phi-fast) is required for fast neutron reactions, fast neutron activation analysis, and for correcting interference reactions. The ffast and subsequently phi-fast were determined using the absolute method. The ffast ranged from 48 to 155, and the phi-fast was found in the range 1.03x1010-4.89x1010 n cm-2 s-1. These values indicate an acceptable conformity and applicable for installation of the fast neutron facility at the MNA research reactor.
Thermal neutron beam from the TNRF of JRR-3M was utilized for detection of mice lung cancer in vivo. Both the static and real-time neutron imaging were tried. Very strong thermal neutron beam is necessary to detect lung cancers because small changes are hidden by the very large attenuation of thermal neutron beam by the hydrogens in the tissues. The detection was successfully performed. Especially, the Super Eye of Hamamatsu Photonics contributed very effectively. Bone marrows and cartilages were also shown clearly. If an efficient and compact neutron source will become available in future, this method will grow up as a powerful tool for biomedical application. (author).
A neutron collimator system is being designed as part of a neutron imaging facility for computed tomography and real-time neutron radiography research at the through beam port of the University of Texas TRIGA reactor. Lack of sufficient information about collimator systems in a through port from the literature necessitated the use of Monte Carlo calculations using the MCNP code 3 to search for optimal design configuration and materials that maximize the thermal neutron intensity at the image plane while minimizing the fast neutrons and gamma radiation.
The dosimetry for radiotherapy involving neutrons is very complicated, owing to the complexity of secondary radiation components, whose contributions to the total absorbed dose have to be discriminated, owing to the different radiobiological effects. In order to separate thermal neutrons and photons, LiF dosimeters are mostly utilized. containing different percentage of Li, like as TLD-700, TLD-100 and TLD-600, but many problems arise. In the response of TLD-700 exposed to neutron-gamma mixed fields with high neutron flux, the contribution of thermal neutrons to the Tl emission is high. Moreover. TLD-100 and TLD-600 may undergo radiation damage, and great care has to be taken in order to obtain reliable results. Other TLDs showing lower sensitivity to neutrons are proposed and experimented for such high-flux neutron fields. The faced ...
A prediction of delayed neutron yields for actinides which are important in the nuclear energy field is given. The prediction is based on a correlation related to a suggested cluster structure of the nucleus. (author).
Neutron yield from the "6","7Li + d reaction has been investigated. The results obtained are compared with the published data with some theoretical models.
The delayed neutrons from neutron-induced fission in /sup 232/U, /sup 237/Np, /sup 238/Pu, /sup 241/Am, /sup 242/Am/sup m/, /sup 245/Cm, and /sup 249/Cf were studied for the first time; those from /sup 232/Th, /sup 233/U, /sup 235/U, /sup 238/U, /sup 239/Pu, /sup 241/Pu, and /sup 242/Pu were measured again. The data were used to develop an expression for the prediction of the absolute delayed neutron yield, and the prediction of delayed neutron emission with time. This approach accurately predicts observed delayed neutron yields and decay characteristics. A fission product yield model was used in conjunction with delayed neutron emission probability to analytically predict delayed neutron characteristics. The results of this analysis are in excellent agreement with experimental values.
The measurements of the total delayed neutron yield from fast neutron induced fission of sup 2 sup 3 sup 8 U were made. The experimental method based on the periodic irradiation of the fissionable sample by neutrons from a suitable nuclear reaction had been employed. The preliminary results on the energy dependence of the total delayed neutron yield from fission of sup 2 sup 3 sup 8 U are obtained. According to the comparison of experimental data with our prediction based on correlation properties of delayed neutron characteristics, it is concluded that the value of the total delayed neutron yield near the threshold of (n,f) reaction is not a constant.
It is shown numerically that on a time scale of order 1 msec a neutron star with pion condensation will undergo separation into a core and an envelope with a sharp interface. The envelope will not, however, be ejected.
For over 50 years, electron beams have been an important modality for providing an accurate dose of radiation to superficial cancers and disease and for limiting the dose to underlying normal tissues and structures. This review looks at many of the important contributions of physics and dosimetry to the development and utilization of electron beam therapy, including electron treatment machines, dose specification and calibration, dose measurement, electron transport calculations, treatment and treatment-planning tools, and clinical utilization, including special procedures. Also, future changes in the practice of electron therapy resulting from challenges to its utilization and from potential future technology are discussed. (review)
Electron beam therapy has often been used for radiation therapy of carcinomas of the buccal mucosa, though side effects, including stomatitis and dermatitis, are known to exist. We experimented using the additional back scatter and transit with the phantom under a lead plate within the irradiation field, in order to better focus the dose on the target volume moreover, we fabricated a mouthpiece fitted with a lead plate shaped to the target volume, and with respect to the influence of the mouthpiece on stomatitis and dermatitis, obtained good clinical results. (author).
Electron beam therapy has often been used for radiation therapy of carcinomas of the buccal mucosa, though side effects, including stomatitis and dermatitis, are known to exist. We experimented using the additional back scatter and transit with the phantom under a lead plate within the irradiation field, in order to better focus the dose on the target volume moreover, we fabricated a mouthpiece fitted with a lead plate shaped to the target volume, and with respect to the influence of the mouthpiece on stomatitis and dermatitis, obtained good clinical results. (author).
Conformal radiation therapy represents a considerable and attractive challenge in oncology. Its aim is mainly to improve local control by increasing the dose with an acceptable rate of complications. This work overviews the world literature on this subject. The technical and theoretical requirements are highlighted. These requirements include a precise definition of the target volume by digital imaging (essentially CT scan), but also clear view of the target volume and the organs at risk, a specific collimation of the beam, 3-D dose calculations, optimization procedures, and a rigid immobilization of the patient with verification of his position. Moreover, the clinical applications of conformal radiation therapy are reviewed and discussed. (authors). 80 refs., 1 tab.
Prostate cancer can be successfully treated using dynamic adaptive external beam radiation techniques along with interstitial brachytherapy to deliver curative therapies with low urinary, rectal and erectile function morbidity. Through the use of sophisticated, state-of-the art radiographic imaging for staging and treatment planning, a precise, individual design for treatment is accomplished. Symptom management and patient education are of paramount importance and are integrated throughout the treatment process.
Innovative therapy may appear to coincide with medical experimentation, raising ethical and legal issues, for instance on informed consent and institutional review. Medical treatments may be classified,...Full Text Available
Background and ObjectivePulsed dye laser (PDL) treatment of cutaneous vascular lesions is associated with variable and unpredictable efficacy. Thus, alternative treatment...Full Text Available
Objectives: Acupuncture has served as a major complementary and alternative therapy that supplements conventional medicine and is the subject of growing public interest. This study was conducted to estimate the usage rate of acupuncture as a supplemental treatment in acute ischaemic stroke patients and to identify factors associated with the choice to use this therapy. Methods: Using the registry of stroke patients admitted to an academic medical centre in Korea, the use of acupuncture therapy was recorded and analysed, along with the patients' socio-demographic characteristics, hospital access variables, risk factors for ischaemic stroke and clinical characteristics. The data were analysed using descriptive statistics, chi-square tests and multiple logistic regression analyses. Results: O...
Mycosis fungoides (MF) in deep-seated lymph nodes, spleen or liver appears to be associated with a lack of response of the disease to topical external therapy. Fourteen patients with mycosis fungoides...Full Text Available
Summary: The increasing emergence of antimicrobial-resistant organisms, especially methicillin-resistant Staphylococcus aureus (MRSA), has resulted in the increased...Full Text Available
Despite high local control rate in Ewing's sarcoma the exact indication of radiation therapy is still controversial as well as the choice of the target volume and the optimal dose of radiation. The importance of the quality of radiotherapy has been stressed in recently published data and has shown a significant impact on long term local control with adequate radiation therapy. The dramatic improvement of precision allowed by the conformal therapy and three dimensional dosimetry allow to expect a decrease of late effects expected for second malignancies. However, late sequelae and radio-induced osteosarcoma still remain the major side effects after radiotherapy. The authors discuss the results of the main trials on Ewing's sarcoma on the choice of dose and target volume. Surgery is still the preferred choice for small tumors if the foreseen outcome is identical. (authors). 28 refs.
Structured abstractObjectiveAlthough most reviews of Pseudomonas aeruginosa therapeutics focus on antibiotics currently in use or...Full Text Available
The success of monoclonal antibodies in clinical practice is dependent on good design. Finding a suitable target is the most important part as other properties of the antibody can be altered by genetic...Full Text Available
Penile rehabilitation therapy following radical prostatectomy is a much debated topic. Erectile dysfunction is still a significant contributor to postoperative morbidity following radical prostatectomy, despite meticulous nerve-sparing technique. Secondary smooth muscle changes in the penis have been identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and fibrosis. Initial observations that intracavernous injection therapies used on a regular basis postoperatively resulted in improvements in the return of spontaneous erectile function led to the development of penile rehabilitation protocols. Chronic dosing of PDE-V inhibitors is now commonly used by urologists after radical prostatectomy. Despite the current enthusiasm of penile rehabilitation therapy, current scientific evidence with clinical trials is still limited. PMID:19255627
PurposeTo identify the extent of persistence (period of time of continuous therapy with the drug prescribed) of glaucoma patients treated with prostaglandins (latanoprost, bimatoprost,...Full Text Available
BackgroundStump and phantom pains are debilitating sequelae of amputations that are often resistant to treatment. The efficacy of pharmacologic therapies, including...Full Text Available
Modern advances in the concept and the techniques of megavoltage radiation therapy have revolutionized the treatment of medulloblastoma. Five-year survivals of 50 to 70 percent are achieved by craniospinalaxis...Full Text Available
BackgroundLymphangioleiomyomatosis (LAM) is a rare lung disease characterised by progressive airflow obstruction. No effective medical treatment is available but therapy with sirolimus...Full Text Available
SYNOPSISPreterm infants are at risk for both iron deficiency and iron overload. The role of iron in multiple organ functions suggests that iron supplementation is essential for...Full Text Available
Hyperglycemia frequently occurs with acute medical illness, especially among patients with cardiovascular disease, and has been linked to increased morbidity and mortality in critically ill patients....Full Text Available
Invasive fungal infections can be devastating, particularly in immunocompromised patients, and difficult to treat with systemic drugs. Furthermore, systemic administration of those medications...Full Text Available
Development of Portable Normobaric Hypoxia and Pulsed Magnetic Field Firmware System for Enhancement of Radio- and Non-specific Resistance in Workers of Environmentally Hazardous Industries
An elderly man receiving chlorambucil for chronic lymphatic leukaemia developed focal fits. The onset and frequency were dose related. There was no evidence of metabolic disturbance or of meningeal...Full Text Available
The potential of radiolabelled phenylpiperazines as agents for the detection and therapy of tumours of neural crest origin was evaluated by in vitro pharmacological studies with human neuroblastoma...Full Text Available
The clinical results of electron beam therapy using intraoral cone in 8 cases of primary and recurrence carcinoma of tongue (T1 and smaller T2) were reported. The primary and recurrence cases were 5 and 3, respectively. In the 5 cases, a total dose of 10-30 Gy external radiation therapy were combined prior to electron beam therapy. The total dose of electron beam therapy varied from 40 to 60 Gy. In all cases, tumor showed good response and disappeared clinically. Radiation stomatitis, pain of the tongue with masticatory disturbance due to tenderness were complicated in all cases. These complications gradually disappeared 2 to 6 months after treatment. However, loss of body weight and bone exposure were not recognized in any case. Intraoral-cone electron beam therapy is thought to be available and has less complications comparing interstitial irradiation therapy ...
Purpose: The purpose of this study was to evaluate the efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in an adjuvant setting with external beam radiation therapy (EBRT) in an experimental prostate cancer model in preparation for a Phase I clinical study in humans. Methods: For efficacy studies, i.m. DU145 and intraprostatic LNCaP C4-2 tumors were established in immune-deficient mice. Tumors were injected with the lytic, replication-competent Ad5-CD/TKrep adenovirus containing a cytosine deaminase (CD)/herpes simplex virus thymidine kinase (HSV-1 TK) fusion gene. Two days later, mice were administered 1 week of 5-fluorocytosine + ganciclovir (GCV) prodrug therapy and fractionated doses of EBRT (trimodal therapy). Tumor control rate of trimodal therapy was compared to that of EBRT alone. For toxicology studies, immune-competent male mice ...
BackgroundTo investigate the effects of intravenous lignocaine infusions (IV lignocaine) in fibromyalgia.MethodsProspective study...Full Text Available
SynopsisAttention-deficit / hyperactivity disorder (ADHD) is a valid and impairing psychological disorder that persists into adulthood in a majority of cases and is associated...Full Text Available
BackgroundAlthough advances in rehydration therapy have made cholera a treatable disease with low case-fatality in settings with appropriate medical care, cholera continues...Full Text Available
... mammography or on ultrasound but not found on physical examination, we consider them non-palpable or not ... lot of this. We send every patient for physical therapy, no matter what type of reconstruction we ...
Previous research with individuals undergoing surgery or diagnostic procedures provided a conceptual framework for analysis of radiation therapy, a common form of cancer treatment. The present...Full Text Available
Antimony toxicity occurs either due to occupational exposure or during therapy. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal...Full Text Available
Adaptive radiation therapy for liver cancer has the potential to reduce normal tissue complications and enable dose escalation, allowing the potential for tumor control in this challenging site....Full Text Available
BackgroundAdequate pain assessment is critical for evaluating the efficacy of analgesic treatment in clinical practice and during the development of new therapies. Yet the currently...Full Text Available
Recent developments in design and production of thermal neutron detectors based on a crystalline Si diode coupled to a Gd converter are reviewed. The most significant results of neutron test measurements carried out on prototype systems and pointing out the performances of the device are reported. Progress through various detection schemes and technological solutions for the production of a real time neutron counter for routine operation are outlined.
Neutron Science Project was started at Japan Atomic Energy Research Institute since 1996 for promoting futuristic basic science and nuclear technology utilizing neutrons. For this purpose, research and developments of intense proton accelerator and spallation neutron target were initiated. The present paper describes the current status of such research and developments. (author)
The characteristics of real-time neutron radiography are described briefly in this paper, and the acquirement of neutron flux, the selection of convertor and the structure of the twilight imaging system and the image-sampling and image-processing system in SPRR-300 reactor are also analyzed detailedly. The experimental result of real-time neutron radiograph is too analyzed in this paper
We describe the continued development of a portable, real-time neutron spectrometer. The spectrometer is composed of two distinct detector systems: a Helium 3 gas filled proportional counter for the lower neutron energy interval between 20 KeV and 2 MeV and a bulk silicon solid state detector for the higher energy interval between 2 MeV and 500 MeV. Modeling and experimental results with mono-energetic neutron beams are reported.
Isospin-breaking effects in the baryonic sector are studied in the framework of a medium-modified Skyrme model. The neutron-proton mass difference in infinite, asymmetric nuclear matter is discussed. In order to describe the influence of the nuclear environment on the skyrmions, we include energy-dependent charged and neutral pion optical potentials in the s- and p-wave channels. The present approach predicts that the neutron-proton mass difference is mainly dictated by its strong part and that it strongly decreases in neutron matter. (orig.)
A 68 MeV neutron transmission experiment on iron has been analyzed with MCNPX using the Los Alamos LA150 neutron data library, the ECN/BRC 150 MeV neutron data library and with the intranuclear cascade code LAHET. The clear improvement of using the data libraries is confirmed. Also, other materials present in LA150 have been checked using the same MCNPX set-up. 10 refs.
In 1998, research began at Idaho National Engineering and Environmental Laboratory to investigate the application of {sup 6}Li and {sup 7}Li isotopes to the measurement of neutron and gamma radiation. Various size pairs of {sup 6}Li and {sup 7}Li based detectors were exposed to mixed neutron and gamma radiation. Experiments demonstrated that these detectors could be used to measure low level neutron radiation in the presence of high level gamma radiation. (author)
In 1998, research began at Idaho National Engineering and Environmental Laboratory to investigate the application of "6Li and "7Li isotopes to the measurement of neutron and gamma radiation. Various size pairs of "6Li and "7Li based detectors were exposed to mixed neutron and gamma radiation. Experiments demonstrated that these detectors could be used to measure low level neutron radiation in the presence of high level gamma radiation. (author)
The field of neutron imaging has a broad scope of applications and has played a pivotal role in visualizing and quantifying hydrogenous masses in metallic matrices. The field continues to expand into new applications with the installation of new neutron imaging facilities. In this scope, a neutron imaging facility for computed tomography and real-time neutron radiography is currently being developed around 2.0 MW TRIGA MARK-II Reactor at Maamora Nuclear Research Centre in Morocco (CENM). The neutron imaging facility consists of a neutron collimator, a real-time neutron imaging system and imaging process systems. In order to reduce the gamma-ray content in the neutron beam, the reactor tangential channel was selected. For power of 250 kW, the corresponding thermal neutron flux measured at the inlet of ...
The field of neutron imaging has a broad scope of applications and has played a pivotal role in visualizing and quantifying hydrogenous masses in metallic matrices. The field continues to expand into new applications with the installation of new neutron imaging facilities. In this scope, a neutron imaging facility for computed tomography and real-time neutron radiography is currently being developed around 2.0 MW TRIGA MARK-II Reactor at Maamora Nuclear Research Centre in Morocco (CENM). The neutron imaging facility consists of a neutron collimator, a real-time neutron imaging system and imaging process systems. In order to reduce the gamma-ray content in the neutron beam, the reactor tangential channel was selected. For power of 250 kW, the corresponding thermal neutron flux measured at the inlet of ...
A thermal neutron imaging facility for real-time neutron radiography and computed tomography has recently been developed and built at the University of Texas TRIGA reactor. Herein the authors present preliminary results of radiography and tomography test experiments. These preliminary results showed that the beam is of high quality and is suitable for radiography and tomography applications. A more detailed description of the facility is given elsewhere.
A thermal neutron imaging facility for real-time neutron radiography and computed tomography has recently been developed and built at the University of Texas TRIGA reactor. Herein the authors present preliminary results of radiography and tomography test experiments. These preliminary results showed that the beam is of high quality and is suitable for radiography and tomography applications. A more detailed description of the facility is given elsewhere
The Albedo Theory was applied in order to develop an one-group algorithm for coupled neutron-gamma shielding calculations. The configuration analyzed consists of multilayered plane systems, where a incident neutron current generates gamma radiation through neutron-gamma reactions. The results obtained by Albedo Method and ANISN code have shown excellent agreement. (author)
A multi-group neutron-gamma cross-section library in DTF-IV format is supplemented with electron production matrix to generate a coupled neutron-gamma-electron library. This is realized by estimating the contributions from Compton scattering, pair production and photoelectric effect to the electron production cross-sections. A novel application of this new library, which involves transport of neutrons, gammas and electrons, for estimating the Compton current due to a pulse of radiation in air is discussed.
A multi-group neutron-gamma cross-section library in DTF-IV format is supplemented with electron production matrix to generate a coupled neutron-gamma-electron library. This is realized by estimating the contributions from Compton scattering, pair production and photoelectric effect to the electron production cross-sections. A novel application of this new library, which involves transport of neutrons, gammas and electrons, for estimating the Compton current due to a pulse of radiation in air is discussed.
To get a considerable reduction of the radiotoxicity due to americium, a thermal neutron fluence of 2.10{sup 22} cm{sup -2} or a fast neutron fluence of 2.10{sup 24} cm{sup -2} is required. Irradiation in a thermal neutron flux leads to lower masses of {sup 234}U and precursors and of {sup 237}Np and precursors, but to higher curium masses and much higher neutron emission rates than irradiation in a fast neutron flux. Therefore, irradiation in a fast neutron flux has preference when multiple recycling is adopted. When once-through burning is applied, irradiation in a thermal neutron flux can be applied. Then irradiation in a heavy water reactor (HWR) has preference above irradiation in a PWR or in a high temperature gas-cooled reactor (HTGR). (authors) 4 refs.
To get a considerable reduction of the radiotoxicity due to americium, a thermal neutron fluence of 2.10{sup 22} cm{sup -2} or a fast neutron fluence of 2.10{sup 24} cm{sup -2} is required. Irradiation in a thermal neutron flux leads to lower masses of {sup 234}U and precursors and of {sup 237}Np and precursors, but to higher curium masses and much higher neutron emission rates than irradiation in a fast neutron flux. Therefore, irradiation in a fast neutron flux has preference when multiple recycling is adopted. When once-through burning is applied, irradiation in a thermal neutron flux can be applied. Then irradiation in a HWR has preference above irradiation in a PWR or in a HTGR. (orig.).
An explanation is given of what a loop heat pipe (LHP) is, and how it works. It is then shown that neutron imaging (both real time neutron radioscopy and single exposure neutron radiography) is an effective experimental tool for the study of LHPs. Specifically, neutron imaging has helped to identify and correct a cooling water distribution problem in the condenser, and has enabled visualization of two-phase flow (liquid and vapor) in various components of the LHP. In addition, partial wick dry-out, a phenomenon of great importance in the effective operation of LHPs, is potentially identifiable with neutron imaging. It is anticipated that neutron radioscopy and radiography will greatly contribute to our understanding of LHP operation, and will lead to improvement of LHP modeling and design. PMID:15246420
An explanation is given of what a loop heat pipe (LHP) is, and how it works. It is then shown that neutron imaging (both real time neutron radioscopy and single exposure neutron radiography) is an effective experimental tool for the study of LHPs. Specifically, neutron imaging has helped to identify and correct a cooling water distribution problem in the condenser, and has enabled visualization of two-phase flow (liquid and vapor) in various components of the LHP. In addition, partial wick dry-out, a phenomenon of great importance in the effective operation of LHPs, is potentially identifiable with neutron imaging. It is anticipated that neutron radioscopy and radiography will greatly contribute to our understanding of LHP operation, and will lead to improvement of LHP modeling and design.
An explanation is given of what a loop heat pipe (LHP) is, and how it works. It is then shown that neutron imaging (both real time neutron radioscopy and single exposure neutron radiography) is an effective experimental tool for the study of LHPs. Specifically, neutron imaging has helped to identify and correct a cooling water distribution problem in the condenser, and has enabled visualization of two-phase flow (liquid and vapor) in various components of the LHP. In addition, partial wick dry-out, a phenomenon of great importance in the effective operation of LHPs, has been identified with neutron imaging. It is anticipated that neutron radioscopy and radiography will greatly contribute to our understanding of LHP operation, and will lead to improvement of LHP modeling and design.
A novel system for real-time radiation monitoring in reactor or accelerator facilities has been studied using an imaging plate. The authors made a feasibility study on a new neutron detection system using both photostimulated luminescence (PSL) and prompt luminescence (PL) generated in a neutron imaging plate (NIP) when the NIP is irradiated by neutrons. A readout system consisting of a semiconductor laser and a photomultiplier tube was fabricated for the purpose. It was confirmed that the system can measure both PSL and PL, where Am-Li was used as a neutron source. It may be possible to establish a new wide-range neutron monitoring system using the developed system as a PL mode normally, and as a PSL mode in case of intense neutron dose that cannot be measured in a PL mode because of saturation of the detection system. (author)
A novel system for real-time radiation monitoring in reactor or accelerator facilities has been studied using an imaging plate. The authors made a feasibility study on a new neutron detection system using both photostimulated luminescence (PSL) and prompt luminescence (PL) generated in a neutron imaging plate (NIP) when the NIP is irradiated by neutrons. A readout system consisting of a semiconductor laser and a photomultiplier tube was fabricated for the purpose. It was confirmed that the system can measure both PSL and PL, where Am-Li was used as a neutron source. It may be possible to establish a new wide-range neutron monitoring system using the developed system as a PL mode normally, and as a PSL mode in case of intense neutron dose that cannot be measured in a PL mode because of saturation of the detection system. (author)
The neutron radiography facility was installed at the tangential beam port of the 3 MW TRIGA MARK-II research reactor. In the facility only direct film neutron radiography method is being used. The project involves development of electronic imaging system for real time neutron radiography in the existing facility with the aim of utilizing it for research and industrial applications. In establishing the electronic imaging system for real time neutron radiography the improvements of existing facility were almost done during this period. In parallel, the former facility was used for the research: (a) A study of wood and wood plastic composites with and without additive by using film neutron radiography and (b) A study of jute reinforced polymer composites by using film neutron radiography technique. (author)
The registration of secondary cosmic ray neutrons is a convenient tool for the investigation of primary cosmic ray variations and for meteorological effects as well. At present a large network of neutron monitors exists, aiming at studies of cosmic ray variations which are related to interplanetary conditions and geomagnetic activity. At the same time cosmic ray variations may be related to some atmospheric processes. In this connection, using the data from two neutron monitors (a standard and a lead free one), a gamma detector from Moscow station and lead free neutron monitor at BEO Moussala, we studied the correlations between rain flows and neutron flux. In this study we used daily averages on the basis of 10 min data for the neutron flux, corrected for barometric pressure and data from local meteo-stations. The preliminary analysis indicates a correlation ...
The University of Virginia's real-time neutron radiography facility was characterized by measurement of the total neutron flux, gold/cadmium ratio, neutron/gamma ratio, and the effective collimar length-to-aperture diameter (L/D) ratio. The real-time neutron imaging system and collimator were further characterized by measuring the modulation transfer function (MTF) of the system. The collimator effectiveness was measured by using the MTF to determine the ''unparallelism'' of the neutron beam. The computer-based image processing system allowed rapid calculation of the MTF and the collimator effectiveness. The results of these measurements, using no collimator and a simple tube collimator, demonstrated the method's ability to determine the effective L/D ratio. The MTF measurement scheme provided a fast, reliable, and reproducible ...
The University of Virginia's real-time neutron radiography facility was characterized by measurement of the total neutron flux, gold/cadmium ratio, neutron/gamma ratio, and the effective collimar length-to-aperture diameter (L/D) ratio. The real-time neutron imaging system and collimator were further characterized by measuring the modulation transfer function (MTF) of the system. The collimator effectiveness was measured by using the MTF to determine the ''unparallelism'' of the neutron beam. The computer-based image processing system allowed rapid calculation of the MTF and the collimator effectiveness. The results of these measurements, using no collimator and a simple tube collimator, demonstrated the method's ability to determine the effective L/D ratio. The MTF measurement scheme provided a fast, reliable, and reproducible means of monitoring any changes in the real-time ...
By using this doping method, silicon semiconductors with extremely uniform dopant distributions can be produced, and this is the dominant advantage of NTD compared with a conventional chemical doping. Good uniformity of a dopant concentration is usually required for high power applications such as thyristor (SCR), IGBT, IGCT and GTO and for special sensors. Achieving an accurate neutron fluence corresponding to a target resistivity as well as a uniform irradiation is the prime target of a neutron irradiation for NTD. Generally, in order to reach an accurate neutron fluence, a real time neutron flux is monitored by a neutron detector such as a Self-powered Neutron Detector(SPND). And, after an irradiation, the total irradiation fluence is confirmed by measuring the absolute activity of a neutron activation sample that has been irradiated with ...
Manned-space missions bring an exposure due to corpuscular radiations of which nature is quite different from what we encounter in the ground environment. In the space environment, many secondaries are produced through interactions of cosmic ray primaries with the spacecraft wall and other surrounding materials. Among this large variety of radiation components in the space, the contribution of neutrons to the radiation exposure of astronauts has remained to be studied. Up to today, efforts to measure neutron dose equivalent have been made using passive detector systems. Considering uncertainties involved in current measurements and estimations of high energy neutrons, and their increasing importance for future manned missions, it is necessary to measure neutron spectrum in the spacecraft under realistic conditions. The neutron spectra have never been measured on board a spacecraft, ...
Neutron semiconductor detectors for neutron counting and neutron radiography have an increasing importance. Simple silicon neutron detectors are combination of a planar diode with a layer of an appropriate neutron converter such as 6LiF. These devices have limited detection efficiency of not more than 5%. The detection efficiency can be increased by creating a 3D microstructure of dips, trenches or pores in the detector and filling it with a neutron converter. The first results related to the development of such devices are presented. Silicon detectors were fabricated with pyramidal dips on the surface covered with 6LiF and then irradiated by thermal neutrons. Pulse height spectra of the energy deposited in the sensitive volume were compared with simulations. The detection efficiency of these devices was about 6.3%. Samples with different ...
An equation of state of neutron star matter with strange baryons has been obtained. The effects of the strength of hyperon-hyperon interactions on the equations of state constructed for the chosen parameter sets have been analysed. Numerous neutron star models show that the appearance of hyperons is connected with the increasing density in neutron star interiors. The performed calculations have indicated that a change of the hyperon-hyperon coupling constants affects the chemical composition of a neutron star. The obtained numerical hyperon star models exclude a large population of strange baryons in the star interior.
The applications of neutron reflectometry to study dynamic phenomena at surface and interfaces have been restricted so far. This was mainly due to the low intensity of neutron sources, but now high-intensity spallation neutron sources are under construction in Japan (J-PARC) and US (SNS). We are planning to install a spin-echo option on the J-PARC neutron reflectometer with horizontal sample geometry for studies of dynamics of surfaces and interfaces. This option is based on the resonance spin-echo method and aimed at dynamics up to hundreds of nanoseconds. In this contribution, the plan and status of development are introduced together with the principle and characteristics of this option.
The polarized triple-axis spectrometer TASP at SINQ has been optimized for measuring magnetic cross sections in condensed matter. The neutrons are polarized or analyzed either by means of benders or Heusler monochromators. The beam divergence, i.e. the intensity, and the spectral range of the neutrons is rather large because of the supermirror coatings of the feeding neutron guide. The intensity can be further increased at the sample position by means of a focussing monochromator and a focussing anti-trumpet. The end position of TASP allows the tailoring of the neutron beam already before the monochromator and to scatter neutrons over very wide ranges of angles. (author) 6 figs., 1 tab., 8 refs.
A helium-3 proportional detector was equipped with the experiment of Liaw-type electrolytic cell contained eutectic LiCl-KCl molten salt saturated by LiD electrolytic to collect the informations of the rate and the energy distribution of possible neutron produced during the electrolysis processes. For long time monitoring, the significant reproducible neutron bursts appeared at several runs of cells during electrolytic processing. The neutron counting rate increased about a factor of two above the level of the background measurement. The pulse height signals were verified of neutron energy ranging from thermal up to 350 keV. (author).
A method of detecting explosives in a vehicle includes providing a first rack on one side of the vehicle, the rack including a neutron generator and a plurality of gamma ray detectors; providing a second rack on another side of the vehicle, the second rack including a neutron generator and a plurality of gamma ray detectors; providing a control system, remote from the first and second racks, coupled to the neutron generators and gamma ray detectors; using the control system, causing the neutron generators to generate neutrons; and performing gamma ray spectroscopy on spectra read by the gamma ray detectors to look for a signature indicative of presence of an explosive. Various apparatus and other methods are also provided.
Measurements were made of the cross section for /sup 242/Am/sup m/ fission induced by neutrons in the energy range 0.04< or =E/sub n/< or =4.52 MeV as well as by neutrons with E/sub n/roughly-equal14.8 MeV. An electrostatic generator and a low-voltage accelerating tube were used to generate the quasimonochromatic neutrons. Measurements in the low-energy region were made by using the time-of-flight technique in neutrons from a nuclear explosion. Results of the measurements are compared with previously published data.
A Si array neutron detector is proposed based on commercial CCD and CMOS sensor technology coupled with a thin film neutron conversion coating. System sensitivity is estimated for a baseline device containing a single array and various schemes to increase detection probability by simple area scaling and stacking are discussed. Some possible use scenarios are discussed involving static and moving sources. Likely neutron source fluxes for weapons grade and commercial grade nuclear material are estimated along with expected intensities of cosmic background neutrons which would establish a noise floor to detection limits.
This paper analyzes fission neutron multiplicity for the /sup 242m/Am(n,f) reaction. The fission neutron multiplicity, v bar, of /sup 242m/Am(n,f) was measured relative to that of /sup 235/U(n,f) using the neutron time-of-flight facility at the Lawrence Livermore National Laboratory 100-MeV electron Linac. A comparison of the measured energy dependence of v-bar is made with semi-empirical models of neutron emission from the actinides. 22 refs.
A method of detecting explosives in a vehicle includes providing a first rack on one side of the vehicle, the rack including a neutron generator and a plurality of gamma ray detectors; providing a second rack on another side of the vehicle, the second rack including a neutron generator and a plurality of gamma ray detectors; providing a control system, remote from the first and second racks, coupled to the neutron generators and gamma ray detectors; using the control system, causing the neutron generators to generate neutrons; and performing gamma ray spectroscopy on spectra read by the gamma ray detectors to look for a signature indicative of presence of an explosive. Various apparatus and other methods are also provided.
Inelastically scattered neutron spectra and angular distributions measured for a number of nuclei at the 9.1 and 14.4 MeV incident neutron energies are fitted well as a sum of neutron evaporation spectrum and the direct interaction part. For the last one the practical scheme of parametrization based on direct interaction theory is presented. The relative contribution of direct interactions in double differential cross sections and parameters of neutron evaporation spectra have been evaluated. All results have a simple physical interpretation and may be useful at interpolating of data in a wide energy interval.
Recently the real-time neutron radiography system of the Kyoto University Reactor (KUR) has been developed and practically applied to penetrating the side plates of the MTR type reactor fuels and investigation of moving objects. In this paper an application of the KUR neutron TV system to neutron computed tomography (NCT) is described. By using the NTV system, projection data can be acquired in a single measurement and simultaneously the projection image can be observed on a CRT monitor. The Fourier-convolution technique is used to produce the reconstructed image and its image has a good enough quality for revealing water in a small hole of 1.5 mm in diameter. (orig.).
Recently the real-time neutron radiography system of the Kyoto University Reactor (KUR) has been developed and practically applied to penetrating the side plates of the MTR type reactor fuels and investigation of moving objects. In this paper an application of the KUR neutron TV system to neutron computed tomography (NCT) is described. By using the NTV system, projection data can be acquired in a single measurement and simultaneously the projection image can be observed on a CRT monitor. The Fourier-convolution technique is used to produce the reconstructed image and its image has a good enough quality for revealing water in a small hole of 1.5 mm in diameter.
Recently the real-time neutron radiography system of the Kyoto University Reactor (KUR) has been developed and practically applied to penetrating the side plates of the MTR type reactor fuels and investigation of moving objects. In this paper an application of the KUR neutron TV system to neutron computed tomography (NCT) is described. By using the NTV system, projection data can be acquired in a single measurement and simultaneously the projection image can be observed on a CRT monitor. The Fourier-convolution technique is used to produce the reconstructed image and its image has a good enough quality for revealing water in a small hole of 1.5 mm in diameter. (orig.).
BackgroundHamstring injuries are the most common injury in Australian Rules football. It was the aims to investigate whether a sports chiropractic manual therapy intervention protocol...Full Text Available
A previously healthy young man experienced several episodes of syncope while being treated with tenofovir, emtricitabine and nevirapine initiated during primary HIV-1 infection. Symptoms disappeared after discontinuation of antiretroviral therapy and we suggest that syncope may be a side effect to one of the three antiretroviral drugs that has not been described previously.
During the past 10 years, five infants with Kasabach-Merritt syndrome (K-M) receiving radiation therapy were reported. We investigated whether radiation therapy for K-M was useful and what the unfavorable factors of K-M were. During the past 10 years, we have treated five infants with K-M. The syndrome occurred at ages ranging from birth to 4 months. The incidence of female to male ratio was 3:2. Among 5 cases, the site of hemangioma was as follows; shoulder, anterior chest wall, lower abdominal wall, face and neck and inguinal site. All 5 cases received medication to control the coagulopathy including prednisone and blood transfusion at first. Because the platelet count and the bleeding tendency did not improve in any case, these cases received radiation therapy. Total dose ranged from 5 to 10 Gy and fraction-size ranged from 0.5 to 1.75 Gy. Irradiation session was 2 or 3 times per week. In 5 cases, 4 cases showed cure of ...
A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.
OBJECTIVE: To present recent evidence on the use of ovarian hormone therapy (OHT) for osteoporosis and outline safe and effective regimens. OPTIONS: Estrogen alone, estrogen and progestins, progestins...Full Text Available
Recent literature indicates that torsion of the left ventricle (LV) is a promising predictor for response to cardiac resynchronisation therapy (CRT). Among patients with severe heart failure, 45 to 75% of patients show rigid body rotation, where the base and apex rotate in the same direction, instead of normal, opposite rotation. The occurrence of this phenomenon seems to be a good indicator for response to CRT. From this review, it can be concluded that LV torsion might be a welcome addition to current selection criteria.
In the 21st century, eighty years after William Baer presented his groundbreaking work treating bone and soft tissue infections with live maggots, thousands of therapists around the globe have rediscovered...Full Text Available
Purpose: To assess the relationship between large intracranial vessel occlusive vasculopathy (vasculopathy) and radiation therapy, and to clarify the clinical efficacy of magnetic resonance (MR) imaging in the diagnosis and screening of the vasculopathy. Methods and Materials: We retrospectively evaluated the medical records and serial MR images for 32 pediatric patients, in whom radiation therapy had been given to fields including the circle of Willis and major cerebral arteries. All children had periodically undergone follow-up neurologic assessment and MR imaging examinations at Kanagawa Children's Medical Center for more than one year after radiation therapy (range 1.3-14 years). Patients who had not remained free of tumor progression up to the time of final evaluation were excluded. Results: Vasculopathy developed in 6 of 32 patients 2-13 years after radiation therapy. Three of them presented with ...
Cell therapy is a promising novel option for treatment of cardiovascular disease. Because the role of bone marrow-derived circulating progenitor cells (BM-CPCs) after cell therapy is less clear, we...Full Text Available
Electron beam therapy applied to a lymph node metastasis from a squamous cell carcinoma was followed by the development of histologically and immunologically typical bullous pemphigoid, the lesions being initially strictly confined to the irradiation area. This observation suggests that the bullous pemphigoid antigen may be altered or unmasked by electron beam radiotherapy, leading subsequently to the production of autoantibodies. The disease in this case effectively responded to the administration of tetracycline and niacinamide, a therapeutic regimen described recently.
A case is presented in which the diagnosis of acute myelomonocytic leukemia was made 16 months after the start of irradation and chemotherapy for Ewing's sarcoma. The association of these two diseases is rare. The etiologic role of therapy in the development of leukemia is speculative in this case. However, there is need for surveillance for secondary neoplasms of all types so that the benefits of therapy may be properly weighed against the risks.
The outcome was retrospectively examined and prognostic factors were discussed for arterial chemo-infusion therapy (ACT) through an implanted reservoir system and radiation therapy (RT) in patients with unresectable intrahepatic cholangiocarcinoma (CCC). ACT plus RT were conducted to 25 patients (mean age 61.7 y, M/F 12/13, stage III-IVB) during 10 years from 1996 to 2005 with various regimens of cisplatin (CDDP), 5- fluorouracil (FU), epirubicin (FARM), mitomycin C (MMC) plus 39-50 Gy of radiation in a fractionated manner partly involving internal RT (2 cases, 15 Gy) and RT for metastatic bone (1, 25 Gy). The survival rates at 1, 2 and 3 years after ACT+RT were respectively 52.5, 43.7 and 28.1%; total efficacy (PR) was 36% (9/25) at 6 months; and significantly good prognostic factors were found to be female and absence of metastasis remote and/or lymphatic around artery. Authors concluded that ACT+RT was a meaningful treatment for highly ...
Sprengel deformity is a congential malformation with usually unilateral elevation and medial rotation of the scapula. An omovertebral bone is generally present. Associated skeletal malformations are frequently present. Though functional impairment is mild, the cosmetic and psycho-social impairment can be considerable. The prognosis of early surgical therapy is good. The presented case also justifies surgical correction in the older child. (orig.) [German] Die Sprengel-Deformitaet ist eine angeborene Fehlbildung mit meist einseitiger Elevation und Medialrotation der Skapula. Meist ist ein Os omovertebrale vorhanden. Assoziierte skelettale Fehlbildungen sind haeufig. Obgleich funktionell wenig einschraenkend, ist die kosmetische und psycho-soziale Beeintraechtigung oft erheblich. Die Prognose der fruehen operativen Therapie ist gut. Der vorliegende Fall ermutigt zur operativen Therapie auch im hoeheren Kindesalter. (orig.)
Until recently no active treatment for advanced or metastatic gastrointestinal stroma tumors (GIST) was available. The tyrosine kinase inhibitor imatinib has revolutionized the treatment of this disease and the median overall survival now reaches 5 years. The standard dose of imatinib is 400 mg per day. Locally advanced GIST should be treated with systemic therapy prior to surgical resection. Imatinib was recently licensed for adjuvant therapy following complete surgical removal of GIST in patients with a significant risk of recurrence. (orig.) [German] Bis vor einigen Jahren existierte keine wirksame systemische Therapie fuer fortgeschrittene oder metastasierte gastrointestinale Stromatumoren (GIST). Der Tyrosinkinaseinhibitor Imatinib hat die Behandlung dieser Tumoren revolutioniert, die mediane Ueberlebenszeit liegt heute bei etwa 5 Jahren. Die Standarddosierung von Imatinib betraegt initial 400 mg/Tag. Lokal ...
Two cases of primary Ewing's sarcoma of the rib are reported, in which radiation therapy was quite effective. Case 1 was an 18-year-old female who had had an operation and radiation therapy for Ewing's sarcoma of the left 7th rib. She was referred to our hospital after a recurrent tumor was found. Radiation therapy (tumor dose 46.2 Gy) and chemotherapy were given. The tumor disappeared and there has been no relapse for 1 year and 3 months after the treatment. Case 2 was a 2-year-old-infant. Radiation therapy (tumor dose 74 Gy) was given for primary Ewing's sarcoma of the left 6th rib. The tumor became small and was successfully removed at operation. There has been no relapse or distant metastasis for 8 months following the operation. We emphasize the importance of multidisciplinary treatment in case 1 and the usefulness of preoperative radiotherapy in case 2. (author).
As part of a general study of personnel neutron dosimetry systems, three British and two German TL albedo dosimeters were compared. They range from simple albedo devices to multi-element devices which detect combinations of incident and albedo neutrons. They were exposed to beams of mono-energetic neutrons, a thermal neutron column and a "2"5"2Cf source. The variation in response with neutron energy above 0.1 MeV was similar for all dosimeters. The resuls show that in general multi-component dosimeters fo not provide enough information to deduce the effective energy of incident neutrons. The choice of single or multi-element dosimeters for particular types of environment is discussed. The Harvey dosimeter has the most acceptable thermal neutron response of the simpler devices. For neutron energies below 0.5 MeV its ...
A system for real-time neutron radiography of moving objects is described. It comprise a source adapted to generate a continuous uninterrupted series of neutron pulses. Each pulse has a predetermined peak power and duration compatible with the framing times of a real-time video imaging system. A transporter moves an object to be examined to bring sequentially position selected portions of the object in the path of the pulses. Where the object itself has moving components, pulses are sequentially incident on the object. According to any dissimilarities, the object will alter the intensity of the neutrons passing therethrough. In order to record separately the changes in the neutron intensity, for each pulse, an imager is positioned to receive the neutron beam pulses which have been altered by their passage through the object and produce images indicating intensity alterations. A ...
A system for real-time neutron radiography of moving objects is described. It comprise a source adapted to generate a continuous uninterrupted series of neutron pulses. Each pulse has a predetermined peak power and duration compatible with the framing times of a real-time video imaging system. A transporter moves an object to be examined to bring sequentially position selected portions of the object in the path of the pulses. Where the object itself has moving components, pulses are sequentially incident on the object. According to any dissimilarities, the object will alter the intensity of the neutrons passing therethrough. In order to record separately the changes in the neutron intensity, for each pulse, an imager is positioned to receive the neutron beam pulses which have been altered by their passage through the object and produce images indicating intensity alterations. A ...
Within the past two and one half years of the project ``Surface Physics With Cold and Thermal Neutron Reflectometry`` a new thermal neutron reflectometer was constructed at the Rhode Island Nuclear Science Center (RINSC). It was used to study various liquid and solid surfaces. Furthermore, neutron reflection experiments were be un at different laboratories in collaboration with Dr. G.P. Fetcher (at Argonne National Laboratory), Dr. T. Russell (IBM Almaden) and Drs. S.K. Satija and A. Karim (at the National Institute for Standards and Technology). The available resources allowed partial construction of an imaging system for ultracold neutrons. It is expected to provide an extremely high resolution in momentum and energy transfer in surface studies using neutron reflectometry. Much of the work reported here was motivated by the possibility of later implementation at the planned ...
When the history of neutrons is considered, three large discoveries are recalled, that is, the discovery of neutrons by Chadwick in 1932, the discovery of the nuclear fission of uranium by Hahn and Strassmann in 1938, and the continuation of chain reaction in nuclear fission by Fermi and others in 1942. In neutron capture reaction, the reaction cross section can become very large. The fields of research, to which neutrons have contributed most as the experimental probe, are neutron activation analysis and neutron diffraction. The development of the prompt gamma ray analyzer at the JRR-3M in Japan Atomic Energy Research Institute is reported. This method eliminates the various defects in ordinary neutron activation analysis. By installing the cold neutron source with hydrogen cooling in the JRR-3M, the new field of ...
In neutron radiography, as in other forms of NDE, it is sometimes desirable to observe dynamic events. This need has generated increased interest in the development of real-time neutron radiography systems and neutron-to-light converter screens optimized for real-time application. Two screens currently available at MURR are: (1) a 0.041-cm-thick Gd_2O_2S screen manufactured by 3M Company and (2) a "6KiF-ZnS(Ag) screen (NE 426) manufactured by Nuclear Enterprises. These screens are presently used in conventional film neutron radiography and represent two of the commercially available screens that have demonstrated the greatest resolution and sensitivity. Unfortunately, these screens have severe limitations when used for real-time neutron radiography. In order to isolate and minimize the factors contributing to these limitations, several neutron absorbers and ...
A technique was developed that permits fluid flow to be visualized even where the flow is completely shrouded by metal. The technique employs real-time neutron radiography, which is similar to x-ray radiography except a collimated beam of neutrons is used. Various combinations of neutron-opaque tracer materials were tested with neutron-transparent fluid. Neutron opaque tracers, such as solid particles, fluid droplets, and streaklines were imaged through metal walls as they convected in neutron-transparent ambient fluid. Visualization of bubbles/voids were evaluated for possible future applications. Surface-flow patterns were also imaged by using neutron-opaque tufts. These techniques were evaluated for image contrast, resolution, and the ability to accurately track fluid flow fields. The techniques were also modeled to optimize contrast in ...
Delayed-neutron (DN) energy spectra following thermal neutron induced fission of /sup 239/Pu as a function of time after fission have been measured, using the beta-neutron time-of-flight (TOF) spectrometer at the University of Lowell. Thermal/epithermal neutrons were produced on the 5.5-MV Van de Graaff accelerator using the /sup 7/Li(p,n)/sup 7/Be reaction. Time spectra over the neutron energy range of 0.01-4.0 MeV were measured for seven different time intervals after fission, each interval containing varying contributions from the six delayed neutrons groups. The DN energy spectra following induced thermal fission of /sup 239/Pu are compared to those resulting from induced thermal fission of /sup 235/U for each of the seven delay time intervals. Decomposition of the measured spectra into six-group DN spectra was accomplished employing an iterative ...
The US Department of Energy (DOE) sponsors an extensive research program to improve the methods, dosimeters, and instruments available to DOE facilities for measuring neutron dose and assessing its effects on the work force. The Total Dose Meter was recently developed for measuring in real time the adsorbed dose of mixed neutron and gamma radiation and for calculating the dose equivalent. The Field Neutron Spectrometer was developed to provide a portable instrument for determining neutron spectra in the workplace for flux-to-dose equivalent conversion and quality factor calculation. The Combination Thermoluminescence/Track Etch Dosimeter (TLD/TED) was developed to extend the effective neutron energy range of the conventional TLDs to improve detection of fast-energy neutrons. An Optically Stimulated Luminescence Dosimeter is presently being developed for ...
A device for detecting neutrons includes a semi-insulated bulk semiconductor substrate having opposed polished surfaces. A blocking Schottky contact comprised of a series of metals such as Ti, Pt, Au, Ge, Pd, and Ni is formed on a first polished surface of the semiconductor substrate, while a low resistivity ("ohmic") contact comprised of metals such as Au, Ge, and Ni is formed on a second, opposed polished surface of the substrate. In one embodiment, n-type low resistivity pinout contacts comprised of an Au/Ge based eutectic alloy or multi-layered Pd/Ge/Ti/Au are also formed on the opposed polished surfaces and in contact with the Schottky and ohmic contacts. Disposed on the Schottky contact is a neutron reactive film, or coating, for detecting neutrons. The coating is comprised of a hydrogen rich polymer, such as a polyolefin or paraffin; lithium or lithium fluoride; or a heavy metal fissionable material. By varying the ...
Radiation portal monitors used for interdiction of illicit materials at borders include highly sensitive neutron detection systems. The main reason for having neutron detection capability is to detect fission neutrons from plutonium. The currently deployed radiation portal monitors (RPMs) from Ludlum and Science Applications International Corporation (SAIC) use neutron detectors based upon 3He-filled gas proportional counters, which are the most common large neutron detector. There is a declining supply of 3He in the world, and thus, methods to reduce the use of this gas in RPMs with minimal changes to the current system designs and sensitivity to cargo-borne neutrons are being investigated. Four technologies have been identified as being currently commercially available, potential alternative neutron detectors to replace the use of 3He in ...
This article provides a survey of neutron scattering experiments in condensed matter research, which are of interest to chemistry. The theoretical background has been treated in a previous issue. The present article consists of two parts. The first part exhibits the range of experimental possibilities by means of a few selected examples. The starting point is classical neutron diffraction by which the position of atomic nuclei may be determined. Additional information on the spatial distribution in the outer electron shells may be obtained via combined X-ray/neutron-diffraction experiments or via the diffraction of polarized neutrons. Progress in instrumentation, due to the development of more intense sources, has influenced especially the fields of small angle scattering and spectroscopy. The second part features domains of research of current interest, where a combination of several ...
The themal neutron sensitivities of SEI and Toshiba FD-P10-7 radiophotoluminescent silver activated metaphosphate glass dosimeters have been measured and studied theoretically. The graphite thermal neutron column attached to the AEEW reactor NESTOR was utilised as a source of thermal neutrons with minimal fast neutron and gamma-ray contamination. Both the neutron removal and gamma correction measurement techniques were applied and these gave consistent results. It was found that the thermal neutron sensitivity of the Toshiba dosimeters is comparable to the most neutron intensitive thermoluminescent materials available. Because of their larger size and higher silver concentration, however, SEI dosimeters are an order of magnitude more neutron sensitive. The neutron sensitivity of FD-7 glass has not ...
The themal neutron sensitivities of SEI and Toshiba FD-P10-7 radiophotoluminescent silver activated metaphosphate glass dosimeters have been measured and studied theoretically. The graphite thermal neutron column attached to the AEEW reactor NESTOR was utilised as a source of thermal neutrons with minimal fast neutron and gamma-ray contamination. Both the neutron removal and gamma correction measurement techniques were applied and these gave consistent results. It was found that the thermal neutron sensitivity of the Toshiba dosimeters is comparable to the most neutron intensitive thermoluminescent materials available. Because of their larger size and higher silver concentration, however, SEI dosimeters are an order of magnitude more neutron sensitive. The neutron sensitivity of FD-7 glass has not ...
The authors review two types of simulators for the analysis of cosmic ray neutron-induced soft errors (SE's). One of them is the neutron-induced soft error simulator (NISES). A recently proposed nuclear reaction theory forms the foundation for the nuclear reaction database used in NISES. The other simulator, the simplified simulator MBGR, is based on a modified version of the burst generation rate (BGR) model. Both simulators accurately simulate neutron-induced SE rates (SER's). MBGR actually provides an easier and quicker estimation of neutron-induced SER's than NISES. On the other hand, NISES covers more applications; it simulates neutron-induced charge collection, multiple-bit SE, and [alpha]-induced SE analysis.
The authors review two types of simulators for the analysis of cosmic ray neutron-induced soft errors (SE's). One of them is the neutron-induced soft error simulator (NISES). A recently proposed nuclear reaction theory forms the foundation for the nuclear reaction database used in NISES. The other simulator, the simplified simulator MBGR, is based on a modified version of the burst generation rate (BGR) model. Both simulators accurately simulate neutron-induced SE rates (SER's). MBGR actually provides an easier and quicker estimation of neutron-induced SER's than NISES. On the other hand, NISES covers more applications; it simulates neutron-induced charge collection, multiple-bit SE, and #alpha#-induced SE analysis
One of the significant factors of neutron radiographic image degradation is scattering blur from the object. A practical method is described to enhance image quality by eliminating the overlapping of scattered thermal neutrons component from the objects in ETRR-2 neutron radiography facility, using aluminum Gd-coated antiscatter grid. The MCNP code was used to determine the optimum grid dimensions that will reduce the scattered thermal neutrons from the object. An experiment was performed to determine the optimum grid height and irradiation time that gives the best image with acceptable geometric unsharpness. Using the MCNP code it was found that 97% of the scattered neutrons were removed by the grid. The wall dimensions and Gd coating are so small that the facility resolution cannot detect the image pattern superposition on the film.
For neutron radiography (NR), photographic techniques have been mainly used for many years. To observe a dynamic event and to test many samples, the real-time neutron radiography (i.e. neutron television - NTV) system has been introduced at the E-2 experimental tube of the Kyoto University Research Reactor (KUR). The NTV system has been practically applied to penetrating the side plates containing boron burnable poison to test MTR type reactor fuel, to investigation of moving objects and to neutron computed tomography (NCT). New approaches using some advanced neutron converters, a high sensitive and resolution TV camera and a high performance image processing system are being undertaken for standard indicators, visualization on air-water two-phase flow, NCT and so on. (author).
Japan Atomic Energy Research Institute (JAERI) is developing the world`s strongest spallation neutron source using high power proton accelerator and promoting a neutron science project for comprehensive studies on basic science and nuclear transmutation of high-level radioactive nuclide from nuclear power stations. For this purpose, JAERI organized the Special Taskforce for Neutron Science and OMEGA Project in April 1996 and reorganized it to Center for Neutron Science in April 1997. During this period, various research plans using the spallation neutron source are proposed and facilities necessary for research are studied by mainly research groups of JAERI. This report describes research plans and results of the preliminary conceptual design study on proposed facilities plan. (author)
Neutron energy spectra were measured for two OSURR experimental facilities. The method of multiple foil activation was used with the SAND-II neutron spectrum unfolding code to obtain spectral data for the Central Irradiation Facility and Rabbit tube. Limited data was obtained for the thermal column using only gold foils. Calculations were made of the neutron environment in various locations using the MORSE code. A shift towards higher neutron energies was observed comparing results for LEU and HEU cores. A slight loss in total thermal neutron flux was measured for all positions. Calculational results show reasonable agreement with measured data.
A thermal neutron imaging facility for real-time neutron radiography and computed tomography has recently been developed at the University of Texas TRIGA reactor. Extensive Monte Carlo design calculations were used to determine optimal design parameters of the neutron collimator system to avoid costly trial and error. Thermal neutron flux determined by gold foil activation is 5 {times} 10{sup 6} n/cm{sup 2}{center_dot}s at the primary imaging location with beam size of 22.5 cm in diameter. The collimation ratio can be varied from 125 to 235. The neutron-to-gamma ratio is 7.8 {times} 10{sup 6} n/cm{sup 2}{center_dot}mR. The facility has been tested for radiography and tomography applications and is now fully operational.
A neutron scanning device was developed in order to obtain accurate neutron intensities of high burn-up BWR fuels. This scanning device was calibrated with a "2"5"2Cf source and used to measure axial distributions of neutron intensities of BWR fuels with various enrichments (2.0%-3.4%) irradiated up to 60 GWd/tU at Fukushima Daini Nuclear Power Station Unit 2(2F-2). The measured neutron intensities were approximated well with power law interpolations on the calculated burn-up values. The neutron intensities calculated by the ORIGEN2-86 code showed good agreements with the measured ones within 20%. (author)
Measurements of neutron and gamma-ray penetrations in an iron shield were performed up to a 60-cm depth in a tightly coupled source shield configuration with the fast-neutron reactor YAYOI as a source. Rates of neutron reactions and gamma-ray dose rates in the iron shield were obtained using activation foils and thermoluminescent dosimeters. Analyses of the experiments were made by using the DOT-III code with coupled neutron and gamma-ray cross sections from ENDF/B-IV and POPOP4 libraries. To obtain the source condition for the iron shield analyses, the calculated spectrum was adjusted to the measured reaction rates at the reactor shield boundary. The calculated neutron and gamma-ray distributions in the iron shield show fairly good agreement with the experiments. The effect of difference in Bondarenko-type self-shielding factors on the analyses of the iron shield is also shown.
A successful boron neutron capture treatment (BNCT) of a patient with multiple liver metastases has been first given in Italy, by placing the removed organ into the thermal neutron column of the Triga research reactor of the University of Pavia. In Finland, FiR 1 Triga reactor with an epithermal neutron beam well suited for BNCT has been extensively used to irradiate patients with brain tumors such as glioblastoma and recently also head and neck tumors. In this work we have studied by MCNP Monte Carlo simulations, whether it would be beneficial to treat an isolated liver with epithermal neutrons instead of thermal ones. The results show, that the epithermal field penetrates deeper into the liver and creates a build-up distribution of the boron dose. Our results strongly encourage further studying of irradiation arrangement of an isolated liver with epithermal neutron fields.
The effects of group structures and weighting functions on neutron penetration through a thick Na-Fe geometry are studied. The recommended broad-group (61-neutron/23-gamma-ray) and few-group (22-neutron/10-gamma-ray) structures are tailored to the sodium and iron resonances, windows, and capture gamma-ray spectra. The best weighting functions are shown to be fine-group fluxes selected from a few key locations in the geometry. These group structures and weighting functions, relative to existing group structures and conventional weighting functions, improve the accuracy of the computed 61-neutron-group Bonner ball responses by up to one hundred percent and of the computed 22-neutron-group results by up to six hundred percent.
An apparatus for non-invasively inspecting an object, such as an item of luggage, for explosives material is described. It comprises a multi-channel thermal neutron inspection system having a plurality of neutron irradiation chambers. Simultaneous operation of several channels increases the maximum system throughput several times. Each chamber has a lithium neutron source which is stimulated to neutron production by a proton beam. Beam switching magnets are energised by pulsing to divert a common proton beam to each source in turn. The initial beam is generated by a radio frequency quadrupole accelerator. The advantages of this system are very low residual source activity and controllable neutron production thereby minimising safety hazards. The irradiation chamber may contain several different gamma ray detectors to identify the elements present in explosives material. In addition, ...
Three electronic personal dosimeters (EPD-N) manufactured by Siemens, serial numbers 0635, 0658, and 0683, were tested at the Radiation Calibration Laboratory for an evaluation of their response to neutron, gamma and x-ray radiation. Designed to provide real-time neutron and photon dosimetry, the EPD-N is capable of estimating and displaying neutron and gamma dose components separately for a range of energies from 50 keV to 7 MeV for photon and 0.025 eV to > 10 MeV for neutron. All tests were conducted using the factory calibrations. A technical representative of the manufacturer indicated that site-specific calibrations are required as factory settings are calibrated for the lowest neutron energy limit of 0.025 eV. This raises concerns about the reliability of these devices in measuring neutrons when calibrations are made for a specific site radiological ...
A new methane cold neutron source has been tested at the IBR-2 pulsed reactor at the Frank Laboratory of Neutron Physics. In a paper the results of experiments at neutron diffractometers HRFD and DN-2 which are placed at the IBR-2 from the methane moderator side are given. A comparison with the results obtained with the conventional water comb-like moderator is performed. The perspectives of the cold source for various kinds of neutron diffraction experiments, including atomic and magnetic structural analysis and real time experiments are discussed. It is shown, that for a huge number of the experiments which are performing at both HRFD and DN-2 the methane cold neutron source provides the better conditions than water comb-like moderator.
The coupled neutron-gamma cross section libraries BUGLE-80 and SAILOR are compared, with focus on gamma production and transport and its sensitivity to the thermal component of the neutron flux. In addition, the importance of the prompt versus delayed components of the gamma source is addressed. Although BUGLE-80 shows some discrepancies in the core region, the two libraries demonstrate similar capability in the vicinity of the pressure vessel and beyond. The delayed fission product gammas from the core have little impact on the local gamma fluxes beyond the pressure vessel. Although thermal neutron capture is the dominant component of the gamma source, there is little sensitivity of the gamma source to uncertainties in the thermal neutron cross sections, due to compensating effects which tend to keep the thermal neutron capture rate relatively constant.
Abstract - We have designed, built, and tested a 2-D pixellated thermal neutron detector. The detector is modeled after the MicroMegas-type structure previously published for collider-type experiments. The detector consists of a 4X4 square array of 1 cm 2 pixels each of which is connected to an individual preamplifier-shaper-data acquisition system. The neutron converter is a 10B film on an aluminum substrate. We describe the construction of the detector and the test results utilizing 252Cf sources in Lucite to thermalize the neutrons.Drift electrode (Aluminum) Converter (10B) 3 mm Conversion gap neutron (-900 V)
The full text follows. A thermal neutron imaging facility (TNIF) capable of real time neutron radiography and computed tomography was developed for the University of Texas TRIGA Mark II (UT-TRIGA) reactor from 1994-1998. The facility was developed with a through reactor beam port capable of producing a 5.2 x 10{sup 6} n/cm{sup 2}/s thermal neutron flux with a gamma dose rate of less than 1 mR/s after collimation. The original TNIF included the UT-TRIGA reactor, neutron collimation array, sample positioning system, neutron image intensifier tube, video camera, computerized image acquisition system, and a radiation shield. A 0.7 mm slit in cadmium was easily detectable using neutron radiography, and 1.4 mm diameter holes bored in an aluminum block were easily resolved using computed neutron tomography. Precise lower limits of the system ...
High precision fundamental neutron physics experiments have been proposed for the intense pulsed spallation neutron beams at JSNS, LANSCE, and SNS to test the standard model and search for new physics. Certain systematic effects in some of these experiments have to be controlled at the few ppb level. The NPD Gamma experiment, a search for the small parity-violating {gamma}-ray asymmetry A{sub Y} in polarized cold neutron capture on parahydrogen, is one example. For the NPD Gamma experiment we developed a radio-frequency resonant spin rotator to reverse the neutron polarization in a 9.5 cm x 9.5 cm pulsed cold neutron beam with high efficiency over a broad cold neutron energy range. The effect of the spin reversal by the rotator on the neutron beam phase space is compared qualitatively to rf neutron spin flippers based on ...
The principal mathematical tools frequently available for calculations in Nuclear Engineering, including coupled neutron-gamma radiations shielding problems, involve the full Transport Theory or the Monte Carlo techniques. The Multigroup Albedo Method applied to shieldings is characterized by following the radiations through distinct layers of materials, allowing the determination of the neutron and gamma fractions reflected from, transmitted through and absorbed in the irradiated media when a neutronic stream hits the first layer of material, independently of flux calculations. Then, the method is a complementary tool of great didactic value due to its clarity and simplicity in solving neutron and/or gamma shielding problems. The outstanding results achieved in previous works motivated the elaboration and the development of this study that is presented in this dissertation. The radiation balance ...
Purpose: The results of therapy in 288 men with pathologic Stage C prostate cancer who underwent radical retropubic prostatectomy (RRP) were analyzed to determine the effects of adjuvant therapy. Methods and Materials: Twenty-seven of the 288 patients received preoperative neoadjuvant hormonal therapy (leuprolide acetate). Postoperatively, 60 patients received adjuvant radiotherapy (RT) to the prostate bed. Follow-up ranged from 3 to 83 months (median = 32 months). Freedom from failure (FFF) was defined as maintaining a serum PSA level of #<=# 0.3 ng/ml. Results: The FFF was 61% at 3 years and 45% at 5 years for the entire group. The FFF following RRP plus RT was 75% at 3 years and 57% at 5 years as compared to 56% at 3 years and 40% at 5 years for RRP without RT (p = 0.049). The FFF following RRP plus neoadjuvant hormonal therapy was 58% at 3 years and 40% at 5 years as compared to 60% at 3 years ...
Retrospective analyses were performed to evaluate the therapeutic efficacy of intra-oral cone (IOC) radiation therapy for carcinoma of the oral tongue, especially about its faculty of local control and complications. Thirty-nine patients with squamous cell carcinoma of the oral tongue were treated with IOC radiation therapy alone or in combination with external irradiation. IOC radiation therapy was given not only for T1 and T2, but also for T3 tumors. Hypofractionation was used for IOC radiation therapy. The 2 year local control rates, including surgical salvage, for T1, T2, T3 and T4 were 100%, 73.3%, 40% and 0%, respectively. The 5 year actuarial survival rates for Stage I, II, III and IV were 100%, 65.3%, 35.4% and 0%, respectively. The incidences of radiation complications, i.e. soft tissue ulceration and osteoradionecrosis, were 42.9% and 2.9%, respectively. It is suggested that relatively high ...
The results of 144 previously untreated cases of primary Ewing's sarcoma of bone are reported with a minimum follow-up of 5 years. This series was treated between 1972 and 1982 at Istituto Ortopedico Rizzoli with a combined therapy. The local control of the disease consisted of amputation (ten cases), resection followed by radiation therapy (35-45 Gy) (48 cases) and radiation therapy alone (40-60 Gy) (86 cases). Adjuvant chemotherapy, rigorously standardized, was performed according two different protocols: the first (85 cases treated in the period 1972-1978) consisted of vincristine (VCR) Adriamycin (doxorubicin) (ADM), and cyclophosphamide (EDX); the second (59 cases treated in the period 1979-1982) of VCR, ADM, EDX and dactinomycin (DACT). At a follow-up of 5 to 16 years (median, 9), 59 patients (41%) are continuously disease-free (CDF), 81 (56%) developed metastatic disease and/or local recurrence, and four (3%) had a ...
The Neutron Radiography Reactor (NRAD) operated by Argonne National Laboratory is described in this paper. NRAD was designed to allow radiography of highly absorbing reactor fuel assemblies in the vertical position on the routine basis. 7 figs.
Revised neutron fluence and damage values are reported for the MOTA-2A experiment in the Fast Flux Test Facility (FFTF). This revision corrects an error with processing of the {sup 235}U(n,f) reaction. Net corrections are on the order of 5%.
An array of multiwire proportional counters has been employed to image, in 'real-time', a collimated neutron beam produced at an electron linac facility. Test results are presented, along with a discussion of the advantages of this technique.
This neutron reflectometry study evaluates the structures resulting from different methods of preparing polymer-cushioned lipid bilayers. Four different techniques to deposit a dimyristoylphosphatidylcholine...Full Text Available
The observation by inelastic neutron scattering techniques of a high energy peak in the phonon spectrum (14 THz) of V_3Si is reported, and is attributed to a peak in the phonon density of states due to vanadium motions by the incoherent inelastic neutron scattering process.
We argue that neutron interference experiments and experiments on gravitational bound states of neutron unambiguously disprove entropic origin of gravitation. The criticism expressed in a recent paper [arXiv:1104.4650] concerning our arguments against entropic gravity is shown to be invalid.
The 1985 evaluation of A = 1-1 (85B1114) has been revised. Experimental information is presented from the neutron-rich {sup 101}Sr to the neutron-deficient {sup 101}In.
The 1985 evaluation of A = 1-1 (85B1114) has been revised. Experimental information is presented from the neutron-rich "1"0"1Sr to the neutron-deficient "1"0"1In.
A study of the joint evolution of the normal- and neutron-star components of massive binaries opens with a classification scheme and the analytic expressions to be applied in Paper II for computer simulation of the observable properties of such systems.
Neutron Star Evolution with Internal Energy h'q/>a. Dissipation by Vortex Creep. N. Shibazaki and F. K. Lamb. University of Illinois at Urbana-Champaign ...
The availability of new, high-intensity, cold and thermal neutron sources has opened the possibility of performing high-precision fundamental neutron physics experiments, including measurements that study the hadronic weak interaction and standard model test measurements, using neutron decay. The observables in these experiments are usually correlated with the direction of neutron polarization and are often very small (10 8 10 6). Mott-Schwinger scattering of polarized neutrons can produce spin-dependent shifts in beam centroids, which has the potential to produce significant systematic effects for these types of experiments. An accurate calculation of this process for neutral atoms and basic molecules has not been carried out for low neutron energies. In this work, we derive a general expression for the electromagnetic (Mott-Schwinger) contributions to the ...
We present the results of modeling intended to evaluate the feasibility of using neutrons from induced fission in highly enriched uranium (HEU) as a means of detecting clandestine HEU, even when it is embedded in absorbing surroundings, such as commercial cargo. We characterized radiation from induced fission in HEU, which consisted of delayed neutrons at all energies and prompt neutrons at energies above a threshold. We found that for the candidate detector and for the conditions we considered, a distinctive HEU signature should be detectable, given sufficient detector size, and should be robust over a range of cargo content. In the modeled scenario, an intense neutron source was used to induce fissions in a spherical shell of HEU. To absorb, scatter, and moderate the neutrons, we place one layer of simulated cargo between the source and target and an identical layer between the ...
The cosmic ray neutron spectrum at sea level has been measured by the method of pulse shape discrimination in anthracene scintillator. The exponent of the differential spectrum was found to be 2.2+-0.1. (Auth.).
An analytic model of magnetic torques applied to an accreting neutron star is employed to evaluate the magnetic dipole moments of x-ray pulsars. A new type of close binary system containing a neutron star is suggested.
A technique was developed that permits fluid flow to be visualized even where the flow is completely shrouded by metal. The technique employs real-time neutron radiography, which is similar to x-ray radiography except a collimated beam of neutrons is used. Various combinations of neutron-opaque tracer materials were tested with neutron-transparent fluid. Neutron opaque tracers, such as solid particles, fluid droplets, and streaklines were imaged through metal walls as they convected in neutron-transparent ambient fluid. Visualization of bubbles/voids were evaluated for possible future applications. Surface-flow patterns were also imaged by using neutron-opaque tufts. These techniques were evaluated for image contrast, resolution, and the ability to accurately track fluid flow fields. The techniques were also modeled to optimize contrast in ...
A prototype detector based on the inclined boron layer principle is introduced. For typical measurement conditions at the Liquids Reflectometer at the Spallation Neutron Source, its count rate capability is shown to be superior to that of the current detector by nearly two orders of magnitude.
A prototype detector based on the inclined absorber layer principle is introduced. For the Liquids Reflectometer at the Spallation Neutron Source, it is shown to be a significant improvement over its current detector, which imposes an instantaneous count rate limitation of 50 kcps.
Main features of star evolution are recalled. Then the general structure of white dwarf stars is examined. From the equation of state of an electron gas completely degenerated are deduced: mechanical equilibrium, Viriel theorem, mass-radius relationship and Chandrasekhar limit. These results are applied to neutron stars.
The personal neutron dosimetry becomes more important with the increasing use of nuclear and accelerator facilities. The solid state track detector, film badge and thermo-luminescent dosimeter have widely been used as passive-type personal neutron dosimeters, but the real-time neutron dosimeter is strongly needed. A real time personal dosimeter which could give neutron dose equivalent over wide energy range from thermal to 10 odd MeV by using two neutron sensors has been developed by our group. For practical commercial product, some changes from these prototype sensors have recently been done by Fuji Electric Co. Ltd. The purpose of this work is the final performance test of the dosimeter just before sale. We checked again about the sensitivity in the monoenergetic neutron field from 8 keV to 15 MeV and in the neutron fields around a few ...
Careful measurements do not confirm an anomalous anisotropy in the angular distribution of fission fragments from the fast neutron fission of Americium 242. The energy range covered was 1.60-3.15 MeV. (AIP)
An array of multiwire proportional counters has been employed to image, in 'real-time', a collimated neutron beam produced at an electron linac facility. Test results are presented, along with a discussion of the advantages of this technique. (orig.).
Phase transformations in TiD_#approx#_0_._7_5 subjected to high-pressure treatment were investigated by simultaneous real-time measurements of neutron diffraction and small-angle neutron scattering. The neutron spectra were taken on heating the samples in temperature ranges 100 to 300 K and 300 to 870 K. A sequence of structural transitions was observed, which involves 7 different phases and intermediate states with hcp, fcc, fco or bcc metal sublattices and hydrogen atoms. 30 refs., 9 figs., 1 tab.
We report on measurements of radiation hardness of the plastic scintillating fiber SCSF-81. Fibers were irradiated with "6"0Co #gamma#-rays and fast neutrons up to 105 Gy and up to 5 x 1013 n/cm"2, respectively. Deterioration of the attenuation length of the scintillating fiber was studied. Some significant deterioration was observed at the integrated dose of about 1 x 103 Gy and at the integrated neutron flux (neutron fluence) of about 1 x 1012 n/cm"2 for #gamma#-ray and neutron irradiation, respectively. (author).
An advanced video system has been assembled from commercially available equipment to support the real-time neutron radiography facility established jointly by the University of Virginia Department of Nuclear Engineering and Engineering Physics, and the Philip Morris Research Center. A schematic diagram of the equipment used for real-time neutron radiography is presented. To obtain quantitative density measurements with this system, several modifications of both hardware and image processing software were required. After implementation of these changes, the system was capable of determining material densities by measuring the degree of neutron attenuation.
An advanced video system has been assembled from commercially available equipment to support the real-time neutron radiography facility established jointly by the University of Virginia Department of Nuclear Engineering and Engineering Physics, and the Philip Morris Research Center. A schematic diagram of the equipment used for real-time neutron radiography is presented. To obtain quantitative density measurements with this system, several modifications of both hardware and image processing software were required. After implementation of these changes, the system was capable of determining material densities by measuring the degree of neutron attenuation.
The neutron elastic magnetic form factor was extracted from quasielastic electron scattering on deuterium over the range Q{sup 2}=1.0-4.8 GeV{sup 2} with the CLAS detector at Jefferson Lab. High precision was achieved with a ratio technique and a simultaneous in situ calibration of the neutron detection efficiency. Neutrons were detected with electromagnetic calorimeters and time-of-flight scintillators at two beam energies. The dipole parametrization gives a good description of the data.
The neutron elastic magnetic form factor was extracted from quasielastic electron scattering on deuterium over the range Q2=1.0-4.8 GeV2 with the CLAS detector at Jefferson Lab. High precision was achieved with a ratio technique and a simultaneous in situ calibration of the neutron detection efficiency. Neutrons were detected with electromagnetic calorimeters and time-of-flight scintillators at two beam energies. The dipole parametrization gives a good description of the data.
Neutron resonance interactions with /sup 100/Mo were studied at a time-of-flight facility. The transmission of two oxide samples (97.4% /sup 100/Mo) was measured at a 78.20 m flight path and the neutron capture cross section was measured at 40.12 m. Resonance analyses yielded parameters of 124 resonances. Capture ..gamma..-ray spectra from 11 resolved resonances were measured with a Ge(Li) detector at a 10.45 m flight path. In contrast to neighboring nuclei, partial radiation widths of strong p-wave resonances are not in agreement with valence model predictions.
Reliable facility of cyclotron-based real time neutron radiography system has been developed and applied to some industrial components. The equipment for neutron fluoroscopy is based on a sub-compact cyclotron and a LiF/ZnS (Ag) fluorescent screen viewed by a silicon intensifier target TV camera. The real time image is monitored on a CRT, recorded with a standard video recorder and processed by a digital image processor. The effectiveness of our real time neutron radiograph has been demonstrated to be applicable to not only the dynamic observation but also the magnifying and stereoscopic observation of fluoroscopic images. (author).
Fission reaction rates for four nuclides were measured in the leakage spectrum outside spherical water moderators of various radii surrounding a {sup 252}Cf neutron source. Using the MCNP transport code, matching calculations were made with highly detailed modeling of the measurement apparatus. The calculations predicted significantly higher leakage of neutrons in the epicadmium energy range than was found in the measurements. A discrepancy of the same sign but weaker magnitude was found for thermal neutrons. These discrepancies may be relevant to problems with criticality calculations in special cases.
Energy conservation and local energy deposition are investigated in the context of coupled-particle (i.e., neutrons, gamma rays, and charged particles) transport analysis. For charged particles, the concept of group splitting the 1 = 0 transfer matrix to ensure both particle and energy conservation is introduced. Although these procedures are more complex than those found in the usual neutron or coupled-neutron gamma-ray problem, they yield a consistent approach for the calculation of local energy deposition.
Energy conservation and local energy deposition are investigated in the context of coupled-particle (i.e., neutrons, gamma rays, and charged particles) transport analysis. For charged particles, the concept of group splitting the 1 = 0 transfer matrix to ensure both particle and energy conservation is introduced. Although these procedures are more complex than those found in the usual neutron or coupled-neutron gamma-ray problem, they yield a consistent approach for the calculation of local energy deposition.
Abstract. The modification of kaon and antikaon properties in the interior of (proto-)neutron stars is investigated using a chiral SU(3) model. The parameters of the model are fitted to nuclear-matter saturation properties, baryon octet vacuum masses, hyperon optical potentials and low-energy kaon-nucleon scattering lengths. We study the kaon/antikaon medium modification and explore the possibility of antikaon condensation in (proto-)neutron star matter at zero as well as finite temperature/entropy and neutrino content. The effect of hyperons on kaon and antikaon optical potentials is also investigated at different stages of the neutron star evolution.
The aim of this work is the implantation and characterization of a neutron radiography system that uses an electronic device for attainment of images in real time, for its implementation in the nuclear research reactor Argonauta at IEN/CNEN (Nuclear Engineering Institute of the Brazilian Nuclear Energy Commission). The Electronic Imaging System in Real Time is composed by a scintillator screen for neutron, a video camera (CCD), a digital plate and a computer with specific computational programs for digital processing of the images. The System in installed real time is apt to carry through neutron radiography inspections of static and dynamic events of several types of samples. (author)
The spherical harmonic analysis of cosmic ray neutron data from the worldwide network neutron monitor stations during the years 1966 to 1969 was carried out. The second zonal harmonic component obtained from the analysis corresponds to the Pole-Equator anisotropy of the cosmic ray neutron intensity. Such an anisotropy makes a semiannual variation. In addition to this, it is shown that the Pole-Equator anisotropy makes a variation depending on the interplanetary magnetic field (IMF) sector polarities around the passages of the IMF sector boundary. A mechanism to interpret these results is also discussed.
We made Basic designs of neutron guide, choppers, and detectors in order to optimize the design parameters of DC-TOF to be built in the HANARO Cold Neutron Guide Hall. In addition, we calculated the expected performance of DC-TOF using Monte Carlo simulations and evaluated the properties of neutron beam. Based on the results we obtained, we have compared the expected performance of the DC-TOF with those of existing instruments overseas. In conclusion, we believe that we will be able to construct the DC-TOF at HANARO as one of the best instruments of its kinds and it will become an invaluable instrument to researchers in the related field.
Instrumental neutron activation analysis is used for simultaneously determination of macrocomponents in ferroelectric materials LLZT. Pb, Zr, Ti have been determined by "2"0"3Pb, "8"9Zr and "4"8Sc nuclides created by fast neutron (14.5 MeV) activation. Application of paraffine as neutron moderator and reflector allows to simultaneously determine lanthanum by "1"4"0La nuclide. It has been shown that zirconium, titanium and lanthanum can be determined with the accuracy of #+-#0.1 mas. % and lead - #+-#0.7 mas. %.
We have developed a new type personal dosemeter by using a B-10 doped silicon p-n junction detector with a polyethylene radiator and a polyethylene moderator. The purpose of this study was to develop a real time neutron dosemeter with a nearly flat response in the energy range from thermal to 15 MeV and low angular dependence to the incident neutron direction. The neutron response of the dosemeter was obtained with the Monte Carlo calculation and the monoenergetic neutron experiment in a free air field and also under a condition attached on a phantom.
A powder neutron diffraction study has been carried out on /sup 239/PuN, which was reported to be antiferromagnetic below T = 13 K. No magnetic ordering has been detected at 4 K, the limit of the magnetic ordering which could be detected being ..mu..sub(ord) = 0.25 ..mu..sub(B) per Pu atom. Moreover a neutron scattering length determination of /sup 239/Pu was performed which gave a value of bsub(239Pu) = (0.81 +- 0.05) x 10/sup -12/ cm at a neutron wavelength lambda = 1.219 A.
Objective A number of effective treatments for bulimia nervosa have been developed, but they are infrequently used, in part due to problems with dissemination. The goal of this study was to examine the cost effectiveness of telemedicine delivery of cognitive behavioral therapy for bulimia nervosa. Method A randomized controlled trial of face-to-face versus telemedicine cognitive behavioral therapy for bulimia nervosa. One hundred twenty eight women with DSM-IV bulimia nervosa or eating disorder, not otherwise specified subsyndromal variants of bulimia nervosa were randomized to 20 sessions of treatment over 16 weeks. A cost effectiveness analysis from a societal perspective was conducted. Results The total cost per recovered (abstinent) subject was $9324.68 for face-to-face CBT, and $7300....
Two patients who developed large intracranial vessel occlusion after standard radiation therapy for brain tumor are described. This form of vascular occlusion is usually seen in patients who have previously been treated by radiotherapy for intracranial tumor who then develop a relatively acute change in neurologic status. Histology of the lesion mimics accelerated focal arteriosclerosis. The clinical and radiographic manifestations of one case were highly atypical. The vasculopathy became evident shortly after termination of radiation therapy for a fourth ventricular ependymoma, and the angiographic picture stimulated a diffuse arteritis. The second patient was more typical, with clinical symptoms developing 12 years after radiation therapy for an oligodendroglioma. Occlusion of a proximal vessel that had been included in the radiation port was demonstrated radiographically and confirmed by pathologic examination. The ...
Two patients who developed large intracranial vessel occlusion after standard radiation therapy for brain tumor are described. This form of vascular occlusion is usually seen in patients who have previously been treated by radiotherapy for intracranial tumor who then develop a relatively acute change in neurologic status. Histology of the lesion mimics accelerated focal arteriosclerosis. The clinical and radiographic manifestations of one case were highly atypical. The vasculopathy became evident shortly after termination of radiation therapy for a fourth ventricular ependymoma, and the angiographic picture stimulated a diffuse arteritis. The second patient was more typical, with clinical symptoms developing 12 years after radiation therapy for an oligodendroglioma. Occlusion of a proximal vessel that had been included in the radiation port was demonstrated radiographically and confirmed by pathologic examination. The ...
The invention refers a procedure of radiation dose control in irradiated tissues during electron-beam therapy. It aims at meeting the planned radiation dose for diseased tissues and taking care of the healthy ones. Therefore, the dose distribution required is determined before irradiation in consideration of such factors as energy-dependence of detector sensitivity, self-absorption within the tissue, and relative biological effectiveness. Furthermore, the expected intensity distribution of secondary quantum radiation excited in the irradiated tissue is calculated. A radiation detector for local resolution is used for registration. During irradiation the calculated intensity distribution is compared with the measured one. The invention is applicable in radiation therapy with monoenergetic electron beams.
Portal localization images for high-energy electron beam therapy are necessary to confirm the treatment field by comparing them with a simulation image obtained before treatment or portal verification images after treatment. In this study, portal localization images were acquired using the computed radiography (CR) system and bremsstrahlung X-rays generated in the electron beam irradiations. All images obtained with phantom and the irradiations of in the electron energy of 8, 10, 12 and 15 MeV were feasible for clinical use. The CR system used in this study included general diagnostic imaging cassette and storage phosphor plate, but none of other special devices. The system can usually supply portal localization images, which maintains the quality assurance of high-energy electron beam therapy. (author)
The aim of this review is to evaluate the role of inflammatory spine disease in patients with chronic back pain. The contribution of imaging modalities for the diagnostic evaluation of back pain is discussed. A systematic literature search based on the classification of seronegative spondyloarthropathies and rheumatoid arthritis was performed. The results of this search and the experiences in a large collective of rheumatological patients are analyzed. The prevalence of rheumatoid arthritis (1-2%) is comparable to that of spondyloarthropathies (1.9%). The etiology of these entities is not fully elucidated. Magnetic resonance imaging is increasingly used for early detection and surveillance of therapy with TNF-#alpha# antagonists. Bone marrow edema, which is only detectable with MRI, represents an early sign of inflammation. Therapy with TNF-#alpha# antagonists is based on clinical and laboratory criteria, and signs of inflammation in MRI. MRI ...
Therapeutic decisions are quite clear-cut for asymptomatic gallstone disease and acute cholecystitis. However, the appropriate therapeutic course for older patients with chronic cholecystitis may be less obvious. Watchful waiting may be reasonable for patients with mild and infrequent symptoms. For healthy patients, cholecystectomy is recommended if symptoms are becoming more frequent and severe. Laparoscopy may reduce the complication rate and be safely performed even in those with underlying medical illness. Oral dissolution therapy can be attempted for qualifying symptomatic patients who are at poor surgical risk or who refuse surgery. Shock wave lithotripsy and contact dissolution therapy show some promise but are currently experimental. PMID:8339941
A long-term follow-up of a patient with beta thalassaemia with intra- and extraspinal extramedullary haematopoietic tissue compressing the spinal cord is presented. Extramedullary haematopoietic nodules are a rare cause of spinal cord compression and should be included in the differential diagnosis, especially in patients from Mediterranean countries. Treatment with radiation therapy solely failed, giving rise to the need of surgical intervention. Surgical decompression of the spine and the removal of the culprit lesion compressing the spine were performed. Postinterventional radiation therapy was applied to the spine. A relapse had to be treated again by surgical means combined with postinterventional radiation therapy. A complete relief of the symptoms and control of the lesion could be obtained.
The philosophy pervading the treatment approach to Ewing's sarcoma was to have therapy encompass all foci of disease, including sites of occult or potential involvement in addition to obvious clinical manifestations. The experience with integrated methods of treatment in 66 consecutive patients at the National Cancer Institute is reviewed. A median survival of 18 months (44 percent 2 year survival rate) for patients with recognizable metastases on admission bears impressive witness to the value of adjuvant therapy in Ewing's sarcoma. Even more encouraging, an uncorrected 5 year survival rate of 53 percent (42 percent continuously free of disease) for patients given ''pyrophylactic'', adjuvant therapy indicates the potential for permanent control of disease in a significant fraction of cases with clinically localized primary tumors. (U.S.).
This study investigated dose to bone tissue in electron beam therapy. Measurements were made using films and thermoluminescent dosimeters in a polystyrene phantom containing bone inhomogeneity for 15-MeV, 12-MeV, and 9-MeV electron beams. An increase in dose of approximately 18%, 12%, and 11%, for the three electron energies respectively, relative to the dose in polystyrene, was found for bone material having an electron density (relative to water) of 1.73. Measurements were also made using films for 15- and 9-Mev electrons in a phantom with a mandibular bone and teeth. A dose enhancement in bone of approximately 10% and 7%, respectively, for the two energies was found in the phantom where the electron density of bone was about 1.60. These results suggest that injury to bone is possible in those clinical situations where high doses of electrons are used for therapy.
This study investigated dose to bone tissue in electron beam therapy. Measurements were made using films and thermoluminescent dosimeters in a polystyrene phantom containing bone inhomogeneity for 15-MeV, 12-MeV, and 9-MeV electron beams. An increase in dose of approximately 18%, 12%, and 11%, for the three electron energies respectively, relative to the dose in polystyrene, was found for bone material having an electron density (relative to water) of 1.73. Measurements were also made using films for 15- and 9-Mev electrons in a phantom with a mandibular bone and teeth. A dose enhancement in bone of approximately 10% and 7%, respectively, for the two energies was found in the phantom where the electron density of bone was about 1.60. These results suggest that injury to bone is possible in those clinical situations where high doses of electrons are used for therapy.
In everyday radiotherapy we must carry out the determination of absorbed dose measurement according to JARP's protocol. We explained an outline of JARP's 1974 and 1986 protocol in electron beam therapy, and mentioned it about the matter that should examined. To use it easily in clinic, a simplified procedure based on precisely to JARP's 1986 protocol is practical, the character of this procedure settles briefly the determination of mean incident energy of electron beams and get ready to table of ionization to absorbed dose conversion factor for various ionization chamber. Also, this procedure almost not influence on the accuracy of determination. We described systematically practical procedure for requisite absorbed dose calculation in a patient in electron beam therapy. (author).
Primary percutaneous coronary intervention (PPCI) is superior to thrombolysis (TL) as reperfusion therapy in ST-elevation myocardial infarction (STEMI). TL is a rapidly available, but semi-effective therapy (effective reperfusion in 50% of patients only), whereas PPCI is a potentially delayed, but highly effective therapy (effective reperfusion in >90%). Since TL loses its efficacy beyond 2?3?h after symptom onset, it is a significant reperfusion alternative to PPCI in early presenters only. The individual decision to treat an early presenter with PPCI or TL requires the evaluation of the time delay between potential start of TL or PPCI, the PCI-related delay (PRD). PRD is greatest, if TL is given in the prehospital setting. Until now, prehospital TL as the most rapidly available reperfusi...
In this study we investigated cultural, familial, and individual beliefs that influenced international students? perceptions of therapy and help-seeking behaviors. Included were changes in perception or behavior before and after the students came to the US, and factors that influenced help-seeking behaviors. Six international students from East Asian countries where English is a foreign language, including Taiwan, Mainland China, Japan, and South Korea, were interviewed. We used semi-structured interviews and participant observations for collecting data. The findings indicated changes after students came to the US. Further discussions focus on encouraging and discouraging factors relative to seeing therapists, and culturally sensitive interventions for family therapy clinicians.
Records of 154 patients with Ewing's sarcoma treated at the National Cancer Institute were reviewed to assess the incidence and risk of developing isolated central nervous system (CNS) Ewing's sarcoma. Sixty-two of the 154 patients had received CNS irradiation and intrathecal (i.t.) methotrexate as part of their initial therapy to prevent the occurrence of isolated CNS Ewing's sarcoma. The risk of developing isolate CNS Ewing's sarcoma was greatest within the first two years after diagnosis and was approximately 10%. The overall risk of CNS recurrence in the group of patients receiving DNS treatment was similar to the group receiving no therapy directed to the CNS. The occurrence of isolated CNS involvement was not prevented by the use of CNS irradiation and i.t. methotrexate. Because of a lack of efficacy to the CNS irradiation regimen, current treatment regimens do not include therapy directed to CNS.
In order to understand the detail transient two-phase flow structure, more advanced two-phase flow instrumentation is required. One advanced technique for flow visualization is real-time neutron radiography. Reconstruction method of visualized radiographic image of liquid metal two-phase flow generated by the real-time neutron radiography system is proposed in this paper. Image processing techniques for noise reduction and image enhancement are discussed in detail. (author).
In order to understand the detail transient two-phase flow structure, more advanced two-phase flow instrumentation is required. One advanced technique for flow visualization is real-time neutron radiography. Reconstruction method of visualized radiographic image of liquid metal two-phase flow generated by the real-time neutron radiography system is proposed in this paper. Image processing techniques for noise reduction and image enhancement are discussed in detail. (author).
Using the Relativistic Mean Field Theory (RMF) it is shown that different proton fraction which is directly connected with the neutron excess and with the asymmetry of the system affects proto-neutron stars parameters and changes their composition. The obtained form of the equation of state allows to construct the mass-radius relations and shows that the increasing asymmetry creates more compact stars. The inclusion of {delta} meson together with nonlinear vector meson interaction terms and magnetic field make this effect even stronger.
The properties of strange neutron stars have been studied with the use of the parameter sets stemming from the effective field theory. The impact of the strength of hyperon interactions on neutron star masses has been analyzed. The inclusion of additional nonlinear meson interaction terms together with the strong hyperon-hyperon interaction leads to the existence of additional stable stellar configurations. (authors)
The current status and future plans of the Ok Ridge Spallation Neutron Source (ORSNS) are reviewed. The ORSNS is a new project initiated by the U.S. Department of Energy (DOE) beginning October 1, 1995, to prepare the conceptual for a new spallation neutron source. (author) 2 refs.
The status of neutron activation cross sections for some threshold reactions important for reactor materials dosimetry is reviewed. An attempt is made to understand and explain discrepancies between integral and differential data, using recent available experimental results. The importance of standard and benchmark neutron fields for testing differential data for reactor dosimetry is emphasized and the Interlaboratory Reaction Rate (ILRR) program, as well as a similar program pursued by the IAEA, are briefly described.
The energy distribution of neutrons generated due to bombardment of 40 MeV alpha particles on thick elemental tantalum is measured using threshold activation detectors. A method of unfolding the neutron spectrum from the activation data based on information-entropy weighted average solution is described. The present unfolding method does not require 'a priori' information about the shape of the solution spectrum. 16 refs. (author).
Structural units of a hydrogen fuel cell whose characteristics are advisable to investigate by different neutron scattering methods are discussed. The results obtained with the use of Bragg diffraction and small-angle neutron scattering from fuel membranes, nanocarbon-platinum catalysts, and Zn_1_-_xCu_xO hydrogen storage systems are presented.
The structural variations of amorphous metals, such as Pd/sub 80/Si/sub 20/, with irradiation of helium ion, neutron, and gamma ray have been mainly pursued by the method of X-ray diffraction and thermal analysis. It should be noticed that the amorphous metals show a radiation resistance, that is, no remarkable structural changes under helium ion, neutron, and gamma ray irradiation.
Recent nucleosynthesis calculations of Type II supernovae using advanced neutrino transport determine that the early neutrino winds are proton-rich. However, a fraction of the ejecta emitted at the same time is composed of neutron-rich pockets. In this paper we calculate the nucleosynthesis contribution from the neutron-rich pockets in the hot convective bubbles of a core-collapse supernova and show that they do not contribute significantly to the total nucleosynthesis.
This meeting focussed on the study of the structure and dynamics of biological molecules, with particular emphasis on neutron and complementary methods as well as related enabling technologies. The program covered biological problems that are being addressed by neutron scattering and those where there is the potential to do so in the future. This document provides the abstracts of the different presentations. (A.L.B.)
The image processing system for the dynamic neutron radiography has been developed. It is based on the hardware subset, composed by the method of the pipe-line and use of algorithm of local statistics. The processing speed per one pixel is shorter than 100 n sec and video-rate processing can be executed on it. Some image processes for improving the quality of the real-time neutron image, noise reduction and contrast stretching would be attempted by the use of this system. (author).
The importance of neutron measurements both as a succinct measure of the progress to fusion ignition using the magnetic confinement route and also as a diagnostic of plasma conditions is discussed. The various neutron diagnostic systems that have been or are being constructed by AERE Harwell for JET are described. The properties to be measured by such diagnostics are clearly identified and some results obtained with the installed diagnostics during d-d plasmas are presented.
ORNL has developed the technology to detect hidden explosives in luggage using X ray and neutron detection devices. The Federal Aviation Administration has ordered the airlines to buy and install Thermal Neutron Analysis (TNA) units. The combined pulsed-neutron and X-ray interrogation inspection (CPNX) system developed at ORNL uses less radioactive materials as well as being more sensitive to weapons, electronic devices and plastic explosives.
The gamma-ray spectrum following neutron capture on /sup 87/Sr was measured at 3 neutron energies: E/sub n/ = thermal, 2 keV, and 24 keV. Gamma rays were detected in a three-crystal Ge(Li)-NaI-NaI pair spectrometer. Gamma-ray intensities deduced from these spectra by spectral unfolding are presented.
A facility for studying photon-neutron reactions under a braking #gamma#-beam with an energy of up to 26 MeV from a betratron includes Saratov-2, SM-4A, and IBM AT-386 microcomputers. Neutron detectors, pulsed braking radiation dosimeters, and the devices to control the betatron energy are described.
In this study the development of a methodology to detect illicit drugs and plastic explosives is described with the objective of being applied in the realm of public security. For this end, non-destructive assay with neutrons was used and the technique applied was the real time neutron radiography together with computerized tomography. The system is endowed with automatic responses based upon the application of an artificial intelligence technique. In previous tests using real samples, the system proved capable of identifying 97% of the inspected materials.
The theory of neutron moderation and spectroscopy are briefly reviewed, and moderators that are useful for Bonner sphere spectrometers are discussed. The choice of the neutron detector for a Bonner sphere spectrometer is examined. Spectral deconvolution methods are briefly reviewed, including derivative, parametric, quadrature, and Monte Carlo methods. Calibration is then discussed. (LEW)
The principal mathematical tools frequently available for calculations in Nuclear Engineering, including coupled neutron-gamma radiations shielding problems, involve the full Transport Theory or the Monte Carlo techniques. The Multigroup Albedo Method applied to shieldings is characterized by following the radiations through distinct layers of materials, allowing the determination of the neutron and gamma fractions reflected from, transmitted through and absorbed in the irradiated media when a neutronic stream hits the first layer of material, independently of flux calculations. Then, the method is a complementary tool of great didactic value due to its clarity and simplicity in solving neutron and/or gamma shielding problems. The outstanding results achieved in previous works motivated the elaboration and the development of this study that is presented in this dissertation. The radiation balance ...
The purpose was to identify human in vitro cell lines with a high relative cellular sensitivity to fast neutrons as compared to photons and to examine their relationship to intrinsic photon radiosensitivity and cellular proliferation kinetics. The clonogenic cell survival following exposure to low LET, 4 MeV photons or, high LET, 62.5 MeV (p #-># Be"+) fast neutrons and the cell survival following exposure to low LET, 4 MeV photons or, high LET, 62.5 MeV (p #-># Be"+) fast neutrons and the cell kinetic parameters of 30 human in vitro cell lines, covering a wide range of histologies, were analyzed alone and with previously published data of Fertil and Malaise. The relative survival at 1.6 Gy of neutrons (SF_1_._6) compared to 2 Gy of photons (SF_2) and the cell kinetic parameters of the 30 cell lines were also compared. The relative lethality of 62.5 MeV fast neutrons was ...
Atypical hemolytic uremic syndrome (aHUS) is a heterogeneous disease that is caused by defective complement regulation in over 50% of cases. Mutations have been identified in genes encoding both complement...Full Text Available
AbstractThe optimal definition of the size, shape and location of gross tumour volume is one of the most important steps in the planning of radiation therapy, and necessitates a proper...Full Text Available
PurposeWe conducted a comparative study of Clinical Target Volume (CTV) definition of pelvic lymph nodes by multiple GU radiation oncologists looking at the levels...Full Text Available
Albeit the considerable progress that has been made both in our understanding of the pathophysiology of acute renal failure (ARF) and in its treatment (continuous renal replacement therapies), the morbidity...Full Text Available
AbstractThere is an urgent need for innovative therapies against ovarian cancer, one of the leading causes of death from gynecological cancers in the United States. Immunotherapy employing...Full Text Available
Background: Patients with a typical depression are more likely to respond to monoamine oxidase inhibitors than to tricyclic antidepressants. They are frequently offered psychotherapy...Full Text Available
HIV-1 nonsubtype B variants account for the majority of HIV infections worldwide. Drug resistance in individuals who have never undergone antiretroviral therapy can lead to early failure and...Full Text Available
Most breast cancers are multicentric in origin. They drain into two primary lymphatic depots—the axilla and internal mammary chain of nodes. The incidence of metastasis to the internal mammary...Full Text Available
Recent reports confirm that, due to the presence of long-lived, latently infected cell populations, eradication of human immunodeficiency virus type 1 (HIV-1) from infected patients by using antiretroviral...Full Text Available
The difficulties created by the lack of generally accepted views on classification, diagnostic criteria and natural history of the cutaneous lymphomata are discussed. Only the lymphomata which remain...Full Text Available
PurposeTo date there remains no effective therapy for metastatic melanoma and at the molecular level disease progression remains poorly understood. Recent work by...Full Text Available
Human antibodies targeting prostate cancer cell surface epitopes may be useful for imaging and therapy. The objective of this study was to evaluate the tumor targeting of an internalizing human...Full Text Available
Total thyroidectomy involving the adjacent structures of the trachea can cause tracheal damage such as early tracheal necrosis. The authors describe the first case of anterior tracheal necrosis following...Full Text Available
Chronic pain patients who show aberrant drug-related behavior often are discontinued from treatment when they are noncompliant with their use of opioids for pain. The purpose of this study was...Full Text Available
Microplanar beam radiation therapy has been proposed to treat brain tumors by using a series of rapid exposures to an array of parallel x-ray beams, each beam having uniform microscopic thickness and...Full Text Available
Oxidative stress contributes to the pathophysiology of exposure to heavy metals/metalloid. Beneficial renal effects of some medications, such as chelation therapy depend at least partially on the ability...Full Text Available
... 46 DOUGLAS BOCCUZZI, MS, DABR: There are some electromagnetic fields in the room, not strong. You can ... 5 weeks or is she feeling any side effects? 00:43:33 SUSAN Y. KIM, MD: She ...
Patients with Alport syndrome progressively lose renal function as a result of defective type IV collagen in their glomerular basement membrane. In mice lacking the α3 chain of type IV collagen...Full Text Available
BackgroundDiscovery of biomarkers that are correlated with therapy response and thus with survival is an important goal of medical research on severe diseases, e.g. cancer. Frequently,...Full Text Available
Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) are highly prevalent in older men. Medical therapy is the first-line treatment for LUTS associated with BPH. Mainstays...Full Text Available
Although major inroads into making antiretroviral therapy available in resource-poor countries have been made, there is an urgent need for an effective vaccine administered shortly after birth, which...Full Text Available
Recurrent or primary carcinoma of the breast en cuirasse, which may involve the skin of the entire thorax and abdomen, cannot be controlled by means of surgery or conventional local irradiation. The...Full Text Available
IntroductionIrradiation of normal, non-malignant bone during cancer therapy can lead to atrophy and increased risk of fracture at several skeletal sites, particularly...Full Text Available
The etiology of major depression remains unknown, but dysfunction of serotonergic signaling has long been implicated in the pathophysiology of this disorder. p11 is an S100 family member recently...Full Text Available
BackgroundIn β-thalassemia, profound anemia and severe hemosiderosis cause functional and physiological abnormalities in various organ systems. In recent years, there have...Full Text Available
SummaryRadiotherapy is used commonly in the treatment of gynecologic malignancies. Many patients experience emotional distress prior to the initiation of radiotherapy, during...Full Text Available
Incidence of esophageal cancer (EC) is rising more rapidly in the Western world than that of any other cancer. Despite advances in therapy, more than 50% of patients have incurable disease at the time...Full Text Available
BackgroundThe aim of this double-blind randomized study is to test the efficacy of a radio electric stimulator device using an auricular reflex therapy protocol for stress-related...Full Text Available
BackgroundThis study aimed to assess whether endoscopic implantation of an injectable esophageal prosthesis, the Gatekeeper Reflux Repair System (GK), is a safe and effective therapy...Full Text Available
Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques. This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which result in additional veno-occlusive dysfunction. Recently, daily use of intracavernous vasoactive substances and oral use of PDE5-inhibitors have been clinically studied for treatment of postprostatectomy erectile dysfunction. Since these studies showed benefits of "penile rehabilitation therapy," these effects have been studied in a preclinical setting. We reviewed experimental literature on erectile tissue preserving and neuroregenerative treatment strategies, and found that preservation of the erectile tissue by the use of intracavernous nitric oxide donors or vasoactive substances, oral PDE5-inhibitors, and hyperbaric oxygen therapy improved erectile function by antifibrotic effects and preservation of ...
1 Measuring total plasma levels of disopyramide (DP) and the main metabolite mono-N-dealkyldisopyramide (MND) in patients on maintenance therapy with DP has shown concentrations of MND comparable with...Full Text Available
Eight patients who had received megavoltage therapy for Cushings' disease 5-12 years previously have been reviewed. The long term response to this therapy was assessed with respect to efficacy of treatment in inducing continued remission and disturbance of hypothalamic-pituitary function. One patient showed clear evidence of relapse of Cushings' disease. One patient had unequivocal hypopituitarism. Basal levels of growth hormone (GH), TSH, LH, and FSH were not statistically different from controls, but provocative testing revealed significant abnormalities of response of cortisol/ACTH, GH, prolactin and LH. Six out of eight patients had absent diurnal cortisol variation and five patients had elevated serum prolactin levels. Thus, in this group of patients normal pituitary-adrenal function has not been satisfactorily restored. It is clear that significant disturbances of hypothalamic-pituitary function follow megavoltage ...
Eight patients who had received megavoltage therapy for Cushings' disease 5-12 years previously have been reviewed. The long term response to this therapy was assessed with respect to efficacy of treatment in inducing continued remission and disturbance of hypothalamic-pituitary function. One patient showed clear evidence of relapse of Cushings' disease. One patient had unequivocal hypopituitarism. Basal levels of growth hormone (GH), TSH, LH, and FSH were not statistically different from controls, but provocative testing revealed significant abnormalities of response of cortisol/ACTH, GH, prolactin and LH. Six out of eight patients had absent diurnal cortisol variation and five patients had elevated serum prolactin levels. Thus, in this group of patients normal pituitary-adrenal function has not been satisfactorily restored. It is clear that significant disturbances of hypothalamic-pituitary function follow megavoltage ...
The ability to achieve tumor selective expression of therapeutic genes is an area that needs improvement for cancer gene therapy to be successful. One approach to address this is through the...Full Text Available
BackgroundThe aim of the study was to compare the prevalence and types of HIV-related oral lesions between children and adult Tanzanian patients on HAART with those not on HAART...Full Text Available
BackgroundReplication capacity (RC) of specific HIV isolates is occasionally blamed for unexpected treatment responses. However, the role of viral RC in response to antiretroviral...Full Text Available
BackgroundStem cell characteristics are an important feature of human cancer cells and play a major role in the therapy resistance of tumours. Strategies to target cancer stem cells...Full Text Available
BackgroundRetinitis pigmentosa (RP) is characterized by progressive night blindness, visual field loss, altered vascular permeability and loss of central vision. Currently there...Full Text Available
The long-term goal of nuclear transfer or alternative reprogramming approaches is to create patient-specific donor cells for transplantation therapy, avoiding immunorejection, a major complication in...Full Text Available
Neurodegenerative and infectious disorders including Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population’s...Full Text Available
The 37/67-kd laminin receptor, LAMR, is a multifunctional protein that associates with the 40S ribosomal subunit and also localizes to the cell membrane to interact with the extracellular matrix. LAMR...Full Text Available
BackgroundThe precise mechanisms involved in the initiation and progression of rheumatoid arthritis (RA) are not known. Early stages of RA often have non-specific symptoms, delaying...Full Text Available
1 An in vitro technique is described for measuring the uptake of 86Rb by human erythrocytes. 2 Fifteen patients were treated with digoxin for atrial fibrillation and other fast arrhythmias. 3 86Rb uptake...Full Text Available
In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease,...Full Text Available
BackgroundThe proteomics approach termed proteome pattern analysis has been shown previously to have potential in the detection and classification of breast cancer. Here we aimed...Full Text Available
Tea ranks second only to water as a major component of fluid intake worldwide and has been considered a health-promoting beverage since ancient times. For the past two decades, we and others...Full Text Available
Patients with haemarthros of the knee were examined by MRI and arthroscopy to identify the bleeding source and to determine surgical or conservative therapy. A prospective study was performed on 120 patients who underwent MRI and arthroscopy, point lesions and bleeding sources were documented separately on a standardised form. Arthroscopy demonstrated a ruptured anterior cruciate ligament in 86%, meniscal tears in 55%, disruption of collateral ligaments in 17%, osteochondral lesions in 5% and tears of capsule or plicae in 13%. Disruption of cruciate ligaments caused haemorrhage in all but three cases. In contrast, only meniscal tears located very adjacent to the meniscal basement had bled. Those types of osteochondral lesions caused haemorrhage characterised on MRI by destruction of the subchondral plate and overlying cartilage. Severe lesions of the knee were diagnosed by MRI in 71% to 100%, slight lesions in 13% to 40% of the cases. Single, combined and bland ...
35 patients with ankle sprain were examined by MRI and stress radiographs. 13 were operated afterwards, 22 patients underwent a functional conservative therapy and were examined by MRI and stress radiographs and second time after three months. MRI reports were correct in 12 of 13 operated cases. After conservative therapy we did not find any disrupted ankle ligament. MRI showed intact ligaments thickened by scar. (orig./MG) [Deutsch] 35 Patienten mit klinischem Verdacht auf Aussenbandruptur wurden mit der MRT untersucht. 13 Patienten wurden operiert, 22 konzervativ therapiert. Letztere wurden nach drei Monaten erneut mit MRT und gehaltenen Aufnahmen untersucht. Die MRT-Befunde stimmten in 12 von 13 Faellen mit den operativ erhobenen Befunden ueberein. Nach dreimonatiger konzervativer Therapie waren alle 22 Sprunggelenke stabil. Die rupturierten Baender stellten sich verdickt und durchgaengig dar. (orig./MG)
In this paper we report a case with primarily unspecific arthralgia after surgical therapy of hallux valgus deformity and consecutive reflex sympathetic dystrophy in which MR led to the diagnosis of Lyme disease. (orig.)
Despite the demonstrated clinical efficacy of CD20 monoclonal antibody (mAb) for lymphoma therapy, the in vivo mechanisms of tumor depletion remain controversial and variable. To identify the molecular...Full Text Available
Sixty glaucomatous eyes of 60 patients treated with laser trabeculoplasty as primary therapy were reviewed retrospectively. There were 42 eyes with capsular glaucoma and 18 with simple glaucoma. The...Full Text Available
Penile rehabilitation has been an area of intense study and debate over the last decade. Interest in this topic was stimulated by the observation that erectile dysfunction remained a significant problem after radical prostatectomy despite meticulous nerve-sparing technique. Smooth muscle alterations and fibrotic changes in the penis were identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and Peyronie's-like changes that were observed after surgery. Initial observations that intracavernous injection therapies used on a regular basis postoperatively resulted in improvements in the return of spontaneous erectile function led to the development of penile rehabilitation protocols. Chronic dosing of oral type V phosphodiesterase inhibitors is now commonly used by urologists after radical prostatectomy despite a lack of convincing evidence from randomized, placebo-controlled clinical trials. Use of local therapies to ...
BackgroundHuman immunodeficiency virus type 1 (HIV-1) infection frequently causes neurologic disease, which is the result of viral replication and activation of macrophages and microglia...Full Text Available
Path analysis was used to determine the interrelationships between postpartum administration of gonadotrophin releasing hormone and cloprostenol and the occurrence of reproductive disease and reproductive...Full Text Available
Bolus infusion of insulin along with a meal is a standard procedure with continuous subcutaneous insulin infusion. Modern insulin pumps allow applying this bolus in four different ways: infusion of...Full Text Available
It is possible to slow down the progression of Alzheimer's disease with pharmacological treatment. When this treatment is given to people with types of dementia that affect the frontal and temporal lobes (Frontotemporal Dementia) the results are discouraging. It is observed that the patients show pronounced restlessness and mania. In this article we describe a nonpharmacological psychosocial approach, music therapy, and how it is possible to work with this method when constitutional, regulative, dialogical, and integrative aspects are included. The focus is on therapeutic singing where well-known songs are applied in order to build up structure and stability and/or as means of arousal regulation. Songs with personal meaning make it possible to acknowledge the person's emotions, breaking the social isolation, and meeting the music therapy participant's psychosocial needs. The clinical approach is an integration of a relational music ...
Immunotherapy has shown promise in a number of tumor types, but its exact role in sarcoma remains to be defined. Advanced bone and soft tissue sarcomas are challenging diseases to treat with an unmet...Full Text Available
Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer therapy. In addition to the transmembrane...Full Text Available
The identification of host cell factors for virus replication holds great promise for the development of new anti-viral therapies. Recently, high-throughput screening methods have emerged as...Full Text Available
Human blinding disorders are often initiated by hereditary mutations that insult rod and/or cone photoreceptors and cause subsequent cellular death. Generally, the disease phenotype can be predicted...Full Text Available
BackgroundRecessive mutations in guanylate cyclase-1 (Gucy2d) are associated with severe, early onset Leber congenital amaurosis-1(LCA1). Gucy2d...Full Text Available
Background:Stem cells can differentiate into multiple cell types, and therefore can be used for cellular therapies, including tissue repair. However, the participation of stem cells...Full Text Available
BackgroundIn patients with Stage 5 Chronic Kidney Disease who require renal replacement therapy a major decision concerns modality choice. However, many patients defer the decision...Full Text Available
BackgroundHerbs and other dietary supplements are among the most commonly used complementary medical therapies. However, clinicians generally have limited knowledge, confidence and...Full Text Available
Patients experiencing several cancers can be a challenge, as optimal treatment options for the different cancers might interfere with each other. In this case report, we present a woman diagnosed with...Full Text Available
Inhaled corticosteroids (ICS) are often prescribed as first-line therapy for patients with asthma Despite their efficacy and improved safety profile compared with oral corticosteroids, the potential...Full Text Available
Colistin is increasingly used as last-line therapy against Gram-negative pathogens. The pharmacokinetic (PK)/pharmacodynamic (PD) index that best correlates with the efficacy of colistin remains undefined....Full Text Available
BackgroundAn artemisinin-based combination therapy, artesunate (AS) plus sulphadoxine-pyrimethamine (SP), was compared to SP monotherapy to provide evidence of further treatment...Full Text Available
BackgroundDespite numerous treatments available for deteriorated cutaneous wound healing such as a diabetic foot, there is still the need for more effective therapy. Adipose-derived...Full Text Available
Background:Continuous renal replacement therapy is used to manage fluid and solute imbalances in critically ill patients but may affect the clearance of concurrently administered...Full Text Available
Authors developed a C-arm type radiosurgery system of the linear accelerator suitable for stereotactic radiation therapy and a software for arranging 3-dimensional therapy in the system. In this system, the gantry far conical irradiation of 4 MV (0.6-3 Gy/min) and 6 MV (0.9-4.5 Gy/min) X ray or electron beam for the therapy was connected to a newly designed C-arm and was made capable of rotating around either of the axes crossing vertically. With this system, it became unnecessary to move the bed table of the patient for getting suitable distribution of radiation dose. The local accuracy which was measured by the CCD videocamera on the gantry, was within 0.5 mm from the radiation center. The system made it possible to shorten the irradiation time and to improve the local accuracy of irradiating site. The clinical trial was begun from June, 1996. (K.H.)
Recent preclinical and clinical data suggest that TP53 status and TP53 mutations may be important in determining tumour aggressiveness and therapy response. In this study we investigate the feasibility...Full Text Available
Lung cancer is the leading cause of cancer deaths worldwide. Standard chemotherapy has been shown to improve quality of life and has a modest influence on overall survival. This modest improvement in...Full Text Available
The results of clinical trials conducted in Europe and North America have been incorporated into treatment strategies for breast cancer in Japan. Despite the use of similar treatment regimens, why has...Full Text Available
BackgroundPolyethyleneimine (PEI), which can interact with negatively charged DNA through electrostatic interaction to form nanocomplexes, has been widely attempted to use as a gene...Full Text Available
Compact dielectric wall (DWA) accelerator technology is being developed at the Lawrence Livermore National Laboratory. The DWA accelerator uses fast switched high voltage transmission lines to generate pulsed electric fields on the inside of a high gradient insulating (HGI) acceleration tube. Its high electric field gradients are achieved by the use of alternating insulators and conductors and short pulse times. The DWA concept can be applied to accelerate charge particle beams with any charge to mass ratio and energy. Based on the DWA system, a novel compact proton therapy accelerator is being developed. This proton therapy system will produce individual pulses that can be varied in intensity, energy and spot width. The system will be capable of being sited in a conventional linac vault and provide intensity modulated rotational therapy. The status of the developmental new technologies that make the compact system possible ...
Objective: To further delineate the clinicopathological and radiological features of solid pseudopapillary tumor (SPT) of the pancreas and summarize the surgical therapy strategy for this tumor. Methods:...Full Text Available
Background & AimsData are conflicting on the benefit of selective serotonin reuptake inhibitors (SSRIs) for patients with irritable bowel syndrome (IBS);...Full Text Available
Carotid artery stenosis is a major risk factor for stroke, and treatments for this condition to decrease the risk of stroke include medical therapy, carotid endarterectomy (CEA), and, more recently,...Full Text Available
BackgroundInadequate platelet inhibition despite aspirin and clopidogrel therapy during and after a percutaneous coronary intervention is associated with an impaired clinical outcome....Full Text Available
Stem cell therapies for neurodegenerative disorders require accurate delivery of the transplanted cells to the sites of damage. Numerous studies have established that fluid injections to the hippocampus...Full Text Available
The diagnostic accuracy of computed tomography (CT) in several patterns of thoracic and abdominal fatty masses, has been examined. In selected cases our findings overlap the features of the recent literature. The possibility of surgical therapy in peculiar cases of adipose deposits, commonly esteemed benign, is considered.
Low bone mineral density (BMD) is prevalent in human immunodeficiency virus (HIV)–infected subjects. Initiation of antiretroviral therapy is associated with a 2%–6% decrease...Full Text Available
- flushing Chemotherapy - what to ask your doctor Dry Mouth Oral mucositis Peripherally inserted central catheter Radiation therapy - what to ask your doctor Safe drinking during...
Nitric oxide (NO)-based therapies effectively inhibit neointimal hyperplasia in animal models of arterial injury and bypass grafting, but are not available clinically. We created a simple, effective,...Full Text Available
Antiplatelet resistance has been proposed as a possible mechanism to explain recurrent cardiovascular events in patients who have coronary artery disease and who are undergoing dual antiplatelet therapy....Full Text Available
Background/AimTobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote...Full Text Available