Energy Technology Data Exchange (ETDEWEB)

Our inability to associate distant regulatory elements with the genes that they regulate has largely precluded their examination for sequence alterations contributing to human disease. One major obstacle is the large genomic space surrounding targeted genes in which such elements could potentially reside. In order to delineate gene regulatory boundaries we used whole-genome human-mouse-chicken (HMC) and human-mouse-frog (HMF) multiple alignments to compile conserved blocks of synteny (CBS), under the hypothesis that these blocks have been kept intact throughout evolution at least in part by the requirement of regulatory elements to stay linked to the genes that they regulate. A total of 2,116 and 1,942 CBS>200 kb were assembled for HMC and HMF respectively, encompassing 1.53 and 0.86 Gb of human sequence. To support the existence of complex long-range regulatory domains ...

Energy Technology Data Exchange (ETDEWEB)

A major regulatory element required for expression of the human [alpha]-globin genes is located 40 kb upstream of the embryonic [zeta]-globin gene. To understand how this and other locus control region (LCR) elements contribute to high-level expression in erythroid cells, we have performed high-resolution, in vivo dimethyl sulfate footprinting. In addition, we have modified the dimethyl sulfate-based ligation-mediated polymerase chain reaction in vivo footprinting procedure to permit the assessment of interactions at guanine and adenine residues, rather than guanines alone. In vivo footprinting of the human [alpha]-LCR element carried on chromosome 16 in a mouse erythroleukemia cell environment revealed protein occupancy at GATA-1, AP-1/NF-E2, and CACC/GGTGG motifs, specific differences compared with in vitro protein binding, and distinct changes in one region upon dimethyl sulfoxide-induced cellular maturation. No protein contacts were ...

UK PubMed Central (United Kingdom)

This paper presents HEARTVIEW - a knowledge base (KB) that offers aid for clinical research in cardiology. This KB is an essential component of the medical workstation MW2000, now under development...Full Text Available

Science.gov (United States)

Sep 8, 2005 ... one of the headquarters buildings here at Stennis, took off .... Also, they have a joint task force, that the ...

Science.gov (United States)

Is global warming contributing to amphibian declines and extinctions by promoting outbreaks of the chytrid fungus Batrachochytrium dendrobatidis? Analyzing patterns ... ...

CERN Document Server

Regulatory Control of Radioactive Waste Management

Science.gov (United States)

... Agard Report 272,1960 ... and reattached subsonic turbulent flows obtained downstream ... of flow separations due to deflected control surfaces. ...

International Nuclear Information System (INIS)

Arguments in favour of the possibility of the existence and the non-existence of tachyons are put forward. Some of the theoretical and experimental attempts which have either supported the view that tachyons exist or not are mentioned. In the light of evidence, available as of now, it is surmised that they may not exist and if they do, they may be neutral in charge. (K.B.).

UK PubMed Central (United Kingdom)

Forum domains are stretches of chromosomal DNA that are excised from eukaryotic chromosomes during their spontaneous non-random fragmentation. Most forum domains are 50–200 kb in length....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

An apparatus is described for measuring the overall decontamination factor of first and second filters, the first and second filters being located in a plenum having an upstream chamber, an intermediate chamber, and a downstream chamber. The first filter is located between the upstream and intermediate chambers and the second filter is located between the intermediate and downstream chambers. The apparatus comprises a. an aerosol generator for producing a challenge aerosol composed of individual particles, the aerosol generator being in fluid communication with the upstream chamber; b. an upstream collector for collecting the challenge aerosol before the challenge aerosol enters the first filter, the upstream collector being disposed in the upstream chamber; c. an intermediate collector for collecting the challenge aerosol that passes through the first filter, the intermediate collector being disposed in the intermediate chamber; and d. a ...

International Nuclear Information System (INIS)

Quantitative ecological risk assessment (ERA) is a means whereby the risk posed by a toxicant in any system can be evaluated by comparing the distribution of its measured or modelled concentrations (water quality data (WQD)) with available information on the range of concentrations that are known to adversely affect biota within that, or similar, habitats (dose-response data (DRD)). Initially, the WQD are compared with regulatory criteria (e.g. ANZECC and ARMCANZ, 2000). If they fail this test, then, on the assumption that both data sets comprise subsets of the entire range of concentrations, probability density functions are derived assuming a standard distribution form a typically log-normal. In this paper, AQUARISK has been used to estimate the risk posed by copper in effluent from the Rum Jungle mine site, pre- and post-remediation, and the proportion of taxa likely to be affected in the East Branch (EB) of the Finniss River downstream of ...

KoreaScience (Korea)

Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The malM locus of Streptococcus pneumoniae was cloned into one of the two PstI sites of the multicopy S. pneumoniae plasmid pMV158. To eliminate chromosomal transformants in the simultaneous selection for tetracycline resistance (coded by pMV158) and maltose utilization, the host cells contained a chromosomal deletion of the mal gene cluster. Two clones were isolated; one with a 3.3 kb insert (pLS70) which behaved like wild type with respect to maltose utilization, and another with a 2.9 kb insert (pLS69) which behaved as though it contained a down promoter mutation. Preliminary mapping of these clones by restriction analysis placed the 0.4kb deletion on a HindIII fragment in the interior of the chromosomal insert. The recombinant plasmids were able to transform over 50% of a recipient population to Mal/sup +/. Enzyme measurements of the clones indicated an overproduction of amylomaltase, constituting up to 10% of the total ...

Energy Technology Data Exchange (ETDEWEB)

A 4.0 kb TaqI fragment of cosmid EFD64 isolated by a HBV-3 oligonucleotide was subcloned into AccI site of pUC18. MspI identifies 5 allelic VNTR polymorphism with bands between 2.6 and 4.6 kb. RsaI, TaqI, EcoRI, BamHI, HindIII and PvuII identify the same VNTR polymorphism. With RsaI, 80% heterozygosity were observed in 80 unrelated Caucasians. This RFLP pEFD64.2 has been assigned to chromosome 3 by linkage analysis with loci (APOD) known to span this chromosome. Co-dominant segregation for the RsaI RFLP was observed in 40 three generation families. RFLPs were observed under the normal hybridization and washing condition.

Science.gov (United States)

In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC(50) values of 3.17 and 3.21 microM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed. PMID:20479985

UK PubMed Central (United Kingdom)

BackgroundCoiled-coil domain containing 115 (Ccdc115) or coiled coil protein-1 (ccp1) was previously identified as a downstream gene of Fibroblast Growth Factor 2 (FGF2) highly expressed...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The aerodynamic forces and wake structure of the non-rotating downstream circular cylinder, of which the uniform free stream flow is interfered with another spinning upstream cylinder having the same diameter that is located upstream in a line have been investigated experimentally. When the spin rate of the downstream cylinder defined as the ratio of tangential surface velocity of the spinning cylinder to the free stream velocity increases gradually from zero to 1.4, the change of surface pressure distribution, aerodynamic forces of the non-rotating downstream cylinder were measured in case of several distance ratios of 1.5, 3.0, and 4.5 defined as the ratio of distance between the centers of two cylinders to the diameter. The wake flow patterns behind the cylinder were also investigated in each case. From the present experiments, it has been found that the spin rate significantly influences the aerodynamic forces and ...

UK PubMed Central (United Kingdom)

Cis-acting regulatory sequences are required for the proper temporal and spatial control of gene expression. Variation in gene expression is highly heritable and a significant determinant...Full Text Available

UK PubMed Central (United Kingdom)

A 7-kb genomic segment containing the coding sequence for the Drosophila melanogaster Formosa variant of salivary gland secretion protein 3 (sgs3) has been inserted into the snw y, bw, st strain of...Full Text Available

Science.gov (United States)

This study examined preliminary psychometric properties of the Teaching Practices Observation Scale (TPOS), a newly developed observational taxonomy for assessing teacher behaviors during free play with young children. Behaviors of 42 child caregivers and junior kindergarten teachers were coded using a combination of time-sampling, event-sampling, and behavior ratings. Findings support the validity of observational coding scheme. (Author/KB)

UK PubMed Central (United Kingdom)

A 13.1-kb DNA fragment carrying Pseudomonas denitrificans cob genes has been sequenced. The nucleotide sequence and genetic analysis revealed that this fragment contained five different cob genes named...Full Text Available

Wastenet

... Most of the received offers were ecolabelled cleaning products and were not more expensive than conventional products. Case 3: The procurement of sustainable cleaning services 104kB Eight cooperating municipalities in the Netherlands needed a new contractor for cleaning services. They wanted to use SPP criteria as well as finding a social employment organisation. SPP criteria for cleaning services were used to set minimum requirements in ...

KoreaScience (Korea)

Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

UK PubMed Central (United Kingdom)

The current obesity pandemic is expected to result in considerable downstream morbidity, mortality and incremental costs to health care systems around the world. The major metabolic complications of...Full Text Available

UK PubMed Central (United Kingdom)

While pleiotropic adaptive mutations are thought to be central for evolution, little is known on the downstream molecular effects allowing adaptation to complex ecologically relevant environments. Here...Full Text Available

International Nuclear Information System (INIS)

Access for independents to retail gas markets was a central concern in European policy reform efforts in the 1990s. Upstream oil and gas companies reacted with strategic intentions of forward integration. By late 2004, forward integration was still weak, however. An important explanation of the gap between announced strategic re-orientation and actual strategy implementation lies in the political failure of EU member states to dismantle market barriers to entry for independents. Variations between companies in downstream strategy implementation are explained by variations in business opportunities and internal company factors.

Energy Technology Data Exchange (ETDEWEB)

Mutations in the mouse formin (Fmn) gene, formerly known as the limb deformity (ld) gene, give rise to recessively inherited limb deformities and renal malformations or aplasia. The Fmn gene encodes many differentially processed transcripts that are expressed in both adult and embryonic tissues. To study the genomic organization of the Fmn locus, we have used Fmn probes to isolate and characterize genomic clones spanning 500 kb. Our analysis of these clones shows that the Fmn gene is composed of at least 24 exons and spans 400 kb. We have identified two novel exons that are expressed in the developing embryonic limb bud as well as adult tissues such as brain and kidney. We have also used a microsatellite polymorphism from within the Fmn gene to map it genetically to a 2.2-cM interval between D2Mit58 and D2Mit103. 36 refs., 6 figs., 1 tab.

British Library Electronic Table of Contents (United Kingdom)

A tertiary structure of recombinant A22^G-B31^K-B32^R-human insulin monomer (insulin GKR) has been characterized by ^1H, ^1^3C NMR at natural isotopic abundance using NOESY, TOCSY, ^1H/^1^3C-GHSQC, and ^1H/^1^3C-GHSQC-TOCSY spectra. Translational diffusion studies indicate the monomer structure in water/acetonitrile (65/35vol.%). CSI analysis confirms existence of secondary structure motifs present in human insulin standard (HIS). Both techniques allow to establish that in this solvent recombinant insulin GKR exists as a monomer. Starting from structures calculated by the program CYANA, two different refinement protocols used molecular dynamics simulated annealing with the program AMBER; in vacuum (AMBER_VC), and including a generalized Born solvent model (AMBER_GB). From these calculation...

Energy Technology Data Exchange (ETDEWEB)

Lethal yellow (A{sup y}) is a mutation at the mouse agouti locus in chromosome 2 that causes a number of dominant pleiotropic effects, including a completely yellow coat color, obesity, an insulin-resistant type II diabetic condition, and an increased propensity to develop a variety of spontaneous and induced tumors. Additionally, homozygosity for A{sup y} results in preimplantation lethality, which terminates development by the blastocyst stage. The A{sup y} mutation is the result of a 170-kb deletion that removes all but the promoter and noncoding first exon of another gene called Raly, which lies in the same transcriptional orientation as agouti and maps 280 kb proximal to the 3{prime} end of the agouti gene. The authors present a model for the structure of the A{sub y} allele that can explain the dominant pleiotropic effects associated with this mutation, as well as the recessive lethality, which is unrelated to the agouti gene.

Energy Technology Data Exchange (ETDEWEB)

Manganese model complexes, relevant to the oxygen-evolving complex (OEC) in photosynthesis, were studied with Mn K-edge X-ray absorption near-edge spectroscopy (XANES), Mn Kb X-ray emission spectroscopy (XES), and vibrational spectroscopy. A more detailed understanding was obtained of the influence of nuclearity, overall structure, oxidation state, and ligand environment of the Mn atoms on the spectra from these methods. This refined understanding is necessary for improving the interpretation of spectra of the OEC. Mn XANES and Kb XES were used to study a di-(mu)-oxo and a mono-(mu)-oxo di-nuclear Mn compound in the (III,III), (III,IV), and (IV,IV) oxidation states. XANES spectra show energy shifts of 0.8 - 2.2 eV for 1-electron oxidation-state changes and 0.4 - 1.8 eV for ligand-environment changes. The shifts observed for Mn XES spectra were approximately 0.21 eV for oxidation state-changes and only approximately 0.04 eV for ...

UK PubMed Central (United Kingdom)

BackgroundThe presence of regulatory T (Treg) cells in human endometrium is crucial for maintaining immunological homeostasis within the uterus. For this study we decided to evaluate...Full Text Available

UK PubMed Central (United Kingdom)

Reverse engineering of gene regulatory networks has been an intensively studied topic in bioinformatics since it constitutes an intermediate step from explorative to causative gene expression...Full Text Available

UK PubMed Central (United Kingdom)

How transcription factors interpret the cis-regulatory logic encoded within enhancers to mediate quantitative changes in spatiotemporally restricted expression patterns during animal...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundA wide range of techniques is now available for analyzing regulatory networks. Nonetheless, most of these techniques fail to interpret large-scale transcriptional data...Full Text Available

Science.gov (United States)

The report analyzes the cost-effectiveness of two alternative regulatory options: A Treated Discharge Option and a Zero Discharge Option. The report compares the total annualized cost incurred for each of the two regulatory options to the corresponding ef...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

International Nuclear Information System (INIS)

Oct 1976. 2 p. United States Nuclear Regulatory Commission, Washington,

Science.gov (United States)

... this critical information, we analyzed 17 years of timber harvest data gathered for regulatory purposes for a ... ...

UK PubMed Central (United Kingdom)

Loss-of-function mutations in the regulatory gene areA of Aspergillus nidulans prevent the utilization of a wide variety of nitrogen sources. The phenotypes of nit-2 mutants of Neurospora crassa suggest...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

In August 1995, the US Nuclear Regulatory Commission (NRC) issued a policy statement proposing improved regulatory decision making by increasing the use of probabilistic risk assessment (PRA) in all regulatory matters to the extent supported by the state-of-the-art in PRA methods and data. A key aspect in using PRA in risk-informed regulatory activities is establishing the appropriate scope and attributes of the PRA. In this regard, the American Society of Mechanical Engineers (ASME) decided to develop a consensus PRA standard. The objective is to develop a PRA standard such that the technical quality of nuclear plant PRAs will be sufficient to support risk-informed regulatory applications. The authors present example recommendations for the systems analysis element of a PRA for incorporation into the ASME PRA standard.

Energy Technology Data Exchange (ETDEWEB)

This report, the eighth in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1992. A special emphasis on accomplishments in nuclear power plant aging research reflects recognition that a number of plants are entering the final portion of their original 40-year operating licenses and that, in addition to current aging effects, a focus on safety considerations for license renewal becomes timely. The primary purpose of performing regulatory research is to develop and provide the Commission and its staff with the technical bases for regulatory decisions on the safe operation of licensed nuclear reactors and facilities, to find unknown or unexpected safety problems, and to develop data and related information for the purpose of revising the ...

Energy Technology Data Exchange (ETDEWEB)

Reliability analysis is now being used to a large extent for several civil engineering structures. Such analysis has not been used for rockfill dams, the most common dams in Norway. Following work on reliability analysis for breakwaters, reliability analysis was then used to investigate the ability of the stone material on the upstream face of a rockfill dam to withstand wind generated waves. An attempt is made to follow up this work by including discharge overtopping on a rockfill dam in a reliability analysis. This report primarily goes through previous work on the required weight of protective stones on the downstream face of the dam for specified discharges over the dam and also deals with the probability formulation of extreme floods. A failure function with partial coefficients is formulated. But for reasons of economy the calibration of the partial coefficients remains for a next phase of the project. 14 refs., 17 figs.

International Nuclear Information System (INIS)

This experiment investigated the effects of free-stream turbulence intensity, length scale, Reynolds number, and leading-edge velocity gradient on stagnation-region heat transfer. Heat transfer was measured in the stagnation region of four models with elliptical leading edges downstream of five turbulence-generating grids. Stagnation-region heat transfer augmentation increased with decreasing length scale but an optimum scale was not found. A correlation was developed that fit heat transfer data for isotropic turbulence to within #+-#4 percent but did not predict data for anisotropic turbulence. Stagnation heat transfer augmentation caused by turbulence was unaffected by the velocity gradient. The data of other researchers compared well with the correlation. A method of predicting heat transfer downstream of the stagnation point was developed. 28 refs., 12 figs., 4 tabs.

British Library Electronic Table of Contents (United Kingdom)

Lisy ME, Jarvis KB, DelBello MP, Mills NP, Weber WA, Fleck D, Strakowski SM, Adler CM. Progressive neurostructural changes in adolescent and adult patients with bipolar disorder.-Bipolar Disord 2011: 13: 396-405. 2011 The Authors.-Journal compilation 2011 John Wiley & Sons A/S. Objectives:- Several lines of evidence suggest that bipolar disorder is associated with progressive changes in gray matter volume (GMV), particularly in brain structures involved in emotional regulation and expression. The majority of these studies however, have been cross-sectional in nature. In this study we compared baseline and follow-up scans in groups of bipolar disorder and healthy subjects. We hypothesized bipolar disorder subjects would demonstrate significant GMV changes over time. Methods:- A total of 58 ...

British Library Electronic Table of Contents (United Kingdom)

Guar seed gum, consisting primarily of a high molecular weight galactomannan, is the most cost effective natural thickener, having broad applications in the food, cosmetics, paper, pharmaceutical and petroleum industries. The properties of the polymer can potentially be enhanced by genetic modification. Development of suitable endosperm-specific promoters for use in guar is desirable for metabolic engineering of the seed gum. A ~1.6?kb guar mannan synthase (MS) promoter region has been isolated. The MS promoter sequence was fused with the GUS reporter gene and overexpressed in the heterologous species alfalfa (Medicago sativa). The potential strength and specificity of the MS promoter was compared with those of the constitutive 35S promoter and the seed specific ?-phaseolin promoter. Quant...

Energy Technology Data Exchange (ETDEWEB)

Transonic flows with heat addition due to condensation are important to many technical applications, e.g. to the last stages of large steam turbines, where nucleation and droplet formation become important. Our current research concentrates on the interaction of vortex shedding with condensation in turbines and on rotor/stator interaction in nucleating flows. Both phenomena lead to a significant change of the condensate mass and the droplet radius distribution in the downstream two-phase flow regime. (orig.)

UK PubMed Central (United Kingdom)

The p90 ribosomal S6 kinases (RSKs) also known as MAPKAP-Ks are serine/threonine protein kinases that are activated by ERK or PDK1 and act as downstream effectors of mitogen-activated protein kinase...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This report, the fifth in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1989. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

Energy Technology Data Exchange (ETDEWEB)

This report, the seventh in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1991. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

Energy Technology Data Exchange (ETDEWEB)

This report, the fourth in a series of annual reports, was prepared in response to Congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during 1988. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

Energy Technology Data Exchange (ETDEWEB)

The authors trace the early history of nuclear power regulation in the US. Focusing on the Atomic Energy Commission, they describe the role of other groups that figured in the development of regulatory policies, including the Congressional Joint Committee on Atomic Energy, other federal agencies, state governments, the nuclear industry, and scientific organizations. They consider changes in public perceptions of and attitudes toward atomic energy and the dangers of radiation exposure. The basic purpose of the book is to provide the Nuclear Regulatory Commission and the general public with information on the historical antecedents and background of regulatory issues so that there will be continuity in policy decisions. The book concludes with an annotated bibliography of selected references. 19 figures.

UK PubMed Central (United Kingdom)

Within the cardiac cell, the movements of calcium ions are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part...Full Text Available

Science.gov (United States)

and used to reduce or replace petroleum-based transportation fuel, heating oil or jet fuel). In addition, this rule includes a new regulatory provision establishing a...

UK PubMed Central (United Kingdom)

In the early 1970s a spate of papers by research groups around the world provided evidence for a negative regulatory role of thymus-derived lymphocytes (T cells). In 1971, Gershon and Kondo published...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Public Law 95-209 includes a requirement that the Advisory Committee on Reactor Safeguards submit an annual report to Congress on the safety research program of the Nuclear Regulatory Commission. This report presents the results of the ACRS review and evaluation of the NRC safety research program for Fiscal Year 1983. The report contains a number of comments and recommendations.

Energy Technology Data Exchange (ETDEWEB)

This report presents information and analysis to assist BLM in clarifying oil shale research needs. It provides technical guidance on research needs in support of their regulatory responsibilities for onshore mineral activities involving oil shale. It provides an assessment of research needed to support the regulatory and managerial role of the BLM as well as others involved in the development of oil shale resources on public and Indian lands in the western United States.

Energy Technology Data Exchange (ETDEWEB)

This document contains eleven papers on various aspects of low-level radioactive waste regulation. Topics include: EPA environmental standards; international exemption principles; the concept of below regulatory concern; envirocare activities in Utah; mixed waste; FUSRAP and the Superfund; and a review of various incentive programs. Individual papers are processed separately for the data base. (TEM)

Energy Technology Data Exchange (ETDEWEB)

The study concludes that while the diversification into nonutility activities by the Rural Electric Cooperatives and the Rural Telephone Cooperatives has been expanding, the regulatory activities by the Rural Electrification Administration and the state public utility commissions have been inadequate to guard against cross-subsidization. In fact, there generally exist no data to identify and investigate illegal cross-subsidization activities of cooperatives. Increasing the regulatory functions of state public utility commissions and the REA was recommended.

UK PubMed Central (United Kingdom)

Background: Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR)...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The goal of this study is to estimate the relevance and Influence of the Existing Regulation and the RI-PBR to the institutionalization of the regulatory system. This study reviews the current regulatory system and the status of the RI-PBR implementation of the US NRC and Korea based upon SECY Papers, Risk Informed Regulation Implementation Plan (RIRIP) of the US NRC and other domestic studies. In order to investigate the perceptions, knowledge level, ground for the regulatory change, a survey was performed to Korean nuclear utilities, researchers and regulators on the perception on the RIR. The questionnaire was composed of 50 questions regarding personal details on work experience, level of education and specific field of work ; level of knowledge on the risk informed performance based regulation (RI-PBR); the perception of the current regulation, the effectiveness, level of procedure, flexibility, dependency on the ...

Energy Technology Data Exchange (ETDEWEB)

This paper overviews the general features of computer program 'HEC-5, Simulation of Flood Control and Conservation Systems', with emphasis on the capabilities of the most recent release of HEC-5, Version 7.2, dated March 1991. HEC-5 can simulate the essential features and operation goals and constraints of simple or complex systems with simulation intervals ranging from minutes to one month. Single event flood analysis and period of record conservation analysis may be accomplished with the model. Flood control analysis includes balanced system operation for downstream damage centers with consideration of forecasted local flows and hydrologic routing. In addition, induced surcharge operation based on spillway gate regulation schedules can be simulated. Hydropower analysis may include run-of-river, peaking, and pumped storage plants as well as system power operation. Water supply simulation can include reservoir and downstream ...

Energy Technology Data Exchange (ETDEWEB)

A numerical study of laminar flow and heat transfer in an array of stacked rectangular plates is presented. The array is placed in a uniform stream, and the plates are subjected to a constant surface heat flux. This flow configuration is relevant to a number of practical heat transfer devices with finned surfaces. The computations were performed using a finite volume solution of the steady, two-dimensional Navier-Stokes equations and energy equation. A numerical scheme that reduces numerical diffusion is used to discretize the equations. The dominant feature of the flow is the separation, and subsequent reattachment of, the boundary layer, which takes place at Reynolds numbers greater than about 75. The separation first occurs downstream of the leading edge of the plate; then as Re increases, the separation point moves upstream and remains fixed at the leading edge, and the reattachment length increases linearly with Re. The appearance and growth of the separation ...

British Library Electronic Table of Contents (United Kingdom)

Wnt signaling negatively regulates adipocyte differentiation, and ectopic expression of Wnt-1 in 3T3-L1 cells induces several downstream molecules of Wnt signaling, including Wnt-1 inducible signaling pathway protein (WISP)-2. In this study, we examined the role of WISP-2 in the process of adipocyte differentiation using an in vitro cell culture system. In the differentiation of 3T3-L1 cells, WISP-2 expression was observed in growing cells and declined thereafter. In the mitotic clonal expansion phase of adipocyte differentiation, WISP-2 expression was transiently down-regulated concurrently with up-regulation of CCAAT/enhancer-binding protein d expression. Treatment of 3T3-L1 cells in the differentiation medium with lithium, an activator of Wnt signaling, inhibited the differentiation pro...

Energy Technology Data Exchange (ETDEWEB)

The present investigation represents the initial phase of a comprehensive experimental program designed to study the potential for increasing the heat transfer per unit pressure drop in a ribbed duct by positioning vortex generators at key locations in the flow. In particular, the present investigation consists of a rib positioned at the inlet to a rectangular test section with uniform heating at its bottom wall. Local and average Nusselt number results are obtained for a circular rod positioned either immediately above or just downstream of the rib.

British Library Electronic Table of Contents (United Kingdom)

Typhoons Aere (2004) and Matsa (2005) caused high nephelometric turbidity in the Shihmen reservoir in northern Taiwan, jeopardizing the operation of the reservoir for several days, and ultimately impacting the living conditions and economy of the downstream residents. The torrential rains caused landslides and debris flows in upland areas, and flowed into riverbeds, likely contributing significantly to the suspended sediment yields in the reservoir. This investigation elucidates how upland landslides affect sediment attributes in the reservoir basin. Study methods including field observations, spatial analysis in GIS and aerial photo interpretation are adopted to trace the sediment sources and contributing factors to the landslide. Torrential rains induced landslides and debris-flows uplan...

International Nuclear Information System (INIS)

The long term objective of the Oil Sands Business Unit of Alberta Energy is to pave the way for Alberta's bitumen production to reach 3 million barrels per day by 2020. This presentation described the national government's role in resource development. It was emphasized that since the Crown is the owner of the oil sands resource, it would benefit by providing strategic leadership and by generating a larger royalty base. The oil sands fiscal regime was described with reference to generic royalty, risk sharing, investment, and project economics. Business rule principles were also outlined along with criteria for project expansions. Both upstream and downstream challenges and opportunities were listed. 4 figs.

International Nuclear Information System (INIS)

In the summer of 1990, an accidental spill from the TA-3 Power Plant Environment Tank released more than 3,785 liters of sulfuric acid into upper Sandia Canyon. The Biological Resource Evaluation Team (BRET) of EM-8 at Los Alamos National Laboratory (LANL) has collected aquatic samples from the stream within Sandia Canyon since then. These field studies gather water quality measurements and collect macroinvertebrates from permanent sampling sites. An earlier report by Bennett (1994) discusses previous BRET aquatic studies in Sandia Canyon. This report updates and expands Bennett's initial findings. During 1993, BRET collected water quality data and aquatic macroinvertebrates at five permanent stations within the canyon. The substrates of the upper three stations are largely sands and silts while the substrates of the two lower stations are largely rock and cobbles. The two upstream stations are located near outfalls that discharge industrial and sanitary waste effluent. The third ...

International Nuclear Information System (INIS)

Industrial radiography accounts for approximately half of all the reported accidents for the nuclear related industry, in both developed and developing countries. This Safety Report is the result of a review made of a large selection of accidents in industrial radiography reported by regulatory authorities, professional associations and scientific journals. A small, representative selection of 43 accident descriptions has been used to illustrate the primary causes of radiography accidents, and a set of measures provided to prevent the recurrence of such accidents or to mitigate the consequences of those that do occur. These accident descriptions were categorized by primary causes as follows: inadequate regulatory control; failure to follow operational procedures; inadequate training; inadequate maintenance; human error; equipment malfunction or defect; design flaws; and wilful violation. The information in this Safety report is intended for use ...

Energy Technology Data Exchange (ETDEWEB)

Specific {sup 32}P-labeled DNA probes were prepared and used to evaluate the distribution of tetracycline resistance determinants carried by gram-negative enteric bacteria isolated from pigs in 3 swine herds with different histories of antibiotic exposure. Plasmid DNA, ranging in size from 2.1 to 186 Kb, was observed in over 84% of 114 isolates studied. Two of 78 tetracycline resistant strains did not harbor plasmids. The DNA probes were isolated from plasmids pSL18, pRT29/Tn10, pBR322 and pSL106, respectively, and they represented class A, B, C and D tetracycline resistance determinants. Hybridization conditions using 0.5X SSPE at 65{degrees}C minimize cross-hybridization between the different class of tetracycline resistance genes. Cross-hybridization between class A and class C determinants could be distinguished by simultaneous comparison of the intensity of their hybridization signals. Plasmids from over 44% of the tetracycline resistant isolates did not ...

CERN Document Server

In this paper, we consider the downlink of large-scale multi-cellular OFDMA-based networks and study performance bounds of the system as a function of the number of users $K$, the number of base-stations $B$, and the number of resource-blocks $N$. Here, a resource block is a collection of subcarriers such that all such collections, that are disjoint have associated independently fading channels. We derive novel upper and lower bounds on the sum-utility for a general spatial geometry of base stations, a truncated path loss model, and a variety of fading models (Rayleigh, Nakagami-$m$, Weibull, and LogNormal). We also establish the associated scaling laws and show that, in the special case of fixed number of resource blocks, a grid-based network of base stations, and Rayleigh-fading channels, the sum information capacity of the system scales as $\\Theta(B \\log\\log K/B)$ for extended networks, and as $O(B \\log\\log K)$ and $\\Omega(\\log \\log K)$ for dense ...

Energy Technology Data Exchange (ETDEWEB)

The neutron radiography system installed at the E-2 experimental hole of the KUR (Kyoto University Reactor) has been used for some NDT applications in the nuclear field. The on-line video image processing system of this facility is introduced in this paper. A 0.5 mm resolution in images was obtained by using a super high quality TV camera developed for X-radiography viewing a NE-426 neutron-sensitive scintillator. The image of the NE-426 on a CRT can be observed directly and visually, thus many test samples can be sequentially observed when necessary for industrial purposes. The video image signals from the TV camera are digitized, with a 33 ms delay, through a video A/D converter (ADC) and can be stored in the image buffer (32 KB DRAM) of a microcomputer (Z-80) system. The digitized pictures are taken with 16 levels of gray scale and resolved to 240 x 256 picture elements (pixels) on a monochrome CRT, with the capability also to display 16 distinct colors on a RGB ...

Energy Technology Data Exchange (ETDEWEB)

[alpha]-Melanocyte stimulating hormone ([alpha]-MSH), a hormone originally named for its ability to regulate pigmentation of melanocytes, is a 13-amino-acid post-translational product of the pro-opiomelanocortin (POMC) gene. [alpha]-MSH and the other products of POMC processing, which share the core heptapeptide amino acid sequence Met-Glu (Gly)-His-Phe-Arg-Trp-Gly (Asp), the adrenocorticotropic hormone (ACTH), [beta]-MSH, and [gamma]-MSH, are collectively referred to as melanocortins. While best known for their effects on the melanocyte (pigmentation) and adrenal cortical cells (steroidogenesis), melanocortins have been postulated to function in diverse activities, including enhancement of learning and memory, control of the cardiovascular system, analgesia, thermoregulation, immunomodulation, parturition, and neurotrophism. To identify the chromosomal band encoding the human melanocortin-1 receptor gene, 1 [mu]g of an EMBL clone coding region of the human MC1R and approximately 15 ...

Energy Technology Data Exchange (ETDEWEB)

The classical phenomenon of position-effect variegation (PEV) is the mosaic expression that occurs when a chromosomal rearrangements moves a euchromatic gene near heterochromatin. A striking feature of this phenomenon is that genes far away from the junction with heterochromatin can be affected, as if the heterochromatic state {open_quotes}spreads.{close_quotes} We have investigated classical PEV of a Drosophila brown transgene affected by a heterochromatic junction {approximately} 60 kb away. PEV was enhanced when the transgene was locally duplicated using P transposase. Successive rounds of P transpose mutagenesis and phenotypic selection produced a series of PEV alleles with differences in phenotype that depended on transgene copy number and orientation. As for other examples of classical PEV, nearby heterochromatin was required for gene silencing. Modifications of classical PEV by alterations at a single site are unexpected, and these observations contradict ...

Energy Technology Data Exchange (ETDEWEB)

We review the recent development of bendable x-ray optics used for focusing of beams of soft and hard x-rays at the Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory and at the Linac Coherent Light Source (LCLS) x-ray free electron laser (FEL) at the Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory. For simultaneous focusing in the tangential and sagittal directions, two elliptically cylindrical reflecting elements, a Kirkpatrick-Baez (KB) pair, are used. Because fabrication of elliptical surfaces is complicated, the cost of directly fabricated tangential elliptical cylinders is often prohibitive. Moreover, such optics cannot be easily readjusted for use in multiple, different experimental arrangements, e.g. at different focal distances. This is in contrast to flat optics that are simpler to manufacture and easier to measure by conventional interferometry. The tangential figure of a flat substrate is changed by placing ...

UK PubMed Central (United Kingdom)

Wiskott-Aldrich syndrome protein (WASp) is essential for optimal T cell activation. Patients with WAS exhibit both immunodeficiency and a marked susceptibility to systemic autoimmunity. We investigated...Full Text Available

UK PubMed Central (United Kingdom)

In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in...Full Text Available

UK PubMed Central (United Kingdom)

Memory consolidation requires transcription and translation of new protein. Arc, an effector immediate early gene, and zif268, a regulatory transcription factor, have been implicated in synaptic plasticity...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYThe biologic and clinical significance of KIT overexpression that associates with KIT gain-of- function mutations occurring in subsets...Full Text Available

UK PubMed Central (United Kingdom)

Promoters are important regulatory elements that contain the necessary sequence features for cells to initiate transcription. To functionally characterize a large set of human promoters, we measured...Full Text Available

UK PubMed Central (United Kingdom)

A positive, genetic selection against the activity of the nitrogen regulatory (NTR) system was used to isolate insertion mutations affecting nitrogen regulation in Klebsiella aerogenes. Two classes...Full Text Available

Wastenet

...broad range of experience in designing and building research and development laboratories for products such as vaccines, blood and sera, biological products, medical devices, solid dosage forms , highly potent products and cytotoxic material. We also have experience in a range of modular laboratories for TSE research, ...

UK PubMed Central (United Kingdom)

Most genetic changes that promote tumorigenesis involve dysregulation of G1 cell cycle progression. A key regulatory site in G1 is a growth factor–dependent restriction point (R) where cells...Full Text Available

UK PubMed Central (United Kingdom)

Protein post-translational modifications are an important biological regulatory mechanism, and the rate of their discovery using high throughput techniques is rapidly increasingly. To make use of this...Full Text Available

UK PubMed Central (United Kingdom)

We examine how the structure and function of indirect flight muscle (IFM) and the entire flight system of Drosophila melanogaster are affected by phosphorylation of the myosin regulatory light chain...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (AU), the Directors` Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM).

Energy Technology Data Exchange (ETDEWEB)

This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Directors' Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM).

Energy Technology Data Exchange (ETDEWEB)

This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM).

UK PubMed Central (United Kingdom)

The Far UpStream Element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream...Full Text Available

UK PubMed Central (United Kingdom)

Although the heart rapidly adapts cardiac output to match the body’s circulatory demands, the regulatory mechanisms ensuring that sufficient ATP is available to perform the required...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNeuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundRecent data show aberrant and altered expression of regulatory noncoding micro (mi) RNAs in prostate cancer (PCa). A large number of miRNAs are encoded in organized intronic...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe immunoregulatory enzyme indoleamine 2,3-dioxygenase, which catalyzes the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundGene regulation is a key mechanism in higher eukaryotic cellular processes. One of the major challenges in gene regulation studies is to identify regulators affecting the...Full Text Available

UK PubMed Central (United Kingdom)

The genetic systems of bacteria that have the ability to use organic pollutants as carbon and energy sources can be adapted to create bacterial biosensors for the detection of industrial pollution....Full Text Available

UK PubMed Central (United Kingdom)

The development of chromatin immunoprecipitation methods coupled with DNA microarray (ChIP-chip) technology has enabled genome-wide identification of cis-DNA regulatory elements to which transcription...Full Text Available

UK PubMed Central (United Kingdom)

Bistability plays a central role in the gene regulatory networks (GRNs) controlling many essential biological functions, including cellular differentiation and cell cycle control. However, establishing...Full Text Available

Science.gov (United States)

The report details the economic impact of two alternative regulatory options; a Treated Discharge Option and a Zero Discharge Option on facilities that would have to comply with the regulations as part of the reproposal of effluent limitations and standar...

UK PubMed Central (United Kingdom)

The ability to adapt to adverse environmental conditions encountered in food and during host infection is a sine qua non for a successful Listeria monocytogenes infection. This ability...Full Text Available

Science.gov (United States)

This analysis, submitted in support of proposed effluent limitations guidelines and standards for the centralized waste treatment (CWT) industry, investigates the cost-effectiveness of 24 regulatory options, representing all possible combinations of nine ...

UK PubMed Central (United Kingdom)

Phosphorus is an essential mineral that maintains cellular energy and mineralizes the skeleton. Because complex actions of ion transporters and regulatory hormones regulate serum phosphorus concentrations,...Full Text Available

UK PubMed Central (United Kingdom)

Zipper-interacting protein kinase (ZIPK) is a member of the death-associated protein kinase family associated with apoptosis in nonmuscle cells where it phosphorylates myosin regulatory light chain...Full Text Available

UK PubMed Central (United Kingdom)

Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system...Full Text Available

UK PubMed Central (United Kingdom)

Oncolytic viruses (OVs) represent a relatively novel anti-cancer modality. Like other new cancer treatments, effective OV therapy will likely require combination with conventional treatments. In order...Full Text Available

UK PubMed Central (United Kingdom)

The accumulation of α-1,4-polyglucans is an important strategy to cope with transient starvation conditions in the environment. In bacteria and plants, the synthesis of glycogen and starch occurs...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundSearching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge for...Full Text Available

UK PubMed Central (United Kingdom)

KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the local cis-regulatory contexts and transcription factor networks...Full Text Available

UK PubMed Central (United Kingdom)

Leaf senescence is a developmentally programmed degeneration process, which is fine tuned by a complex regulatory network for plant fitness. However, molecular regulation of leaf senescence is poorly...Full Text Available

International Nuclear Information System (INIS)

Oil and gas industry is the largest user of radioactive materials in Nigeria. They make use of radiation generators, sealed and unsealed radioactive sources.Some of these are potentially dangerous to human health and environment if not properly controlled. here is also the need to maintain control over occupational exposures to radiation, as well as to protect the public and the environment through proper management of wastes that may be radiologically hazardous. To minimize these, effective regulatory infrastructure is being put in place.For a smooth take-off of the nuclear power program, the National Nuclear Regulatory Authority and other stake holders in the nuclear industry need to start to put together licensing procedure for these.

Energy Technology Data Exchange (ETDEWEB)

In this study, the state-of-the art for estimating LERF is considered for the regulatory risk-informed decisions. The consideration is mainly focused on (1) the relationship between Level 2 PSA and LERF evaluation methodology, (2) the standard requirements in terms of modeling preparation and the acceptance criteria based on the application capability II of ASME PRA standard, and (3) some pending issues for developing and proposing a simplified LERF model. This study is preliminarily presented and will be updated for establishing detailed evaluation scheme of extended MPAS (multi-purpose probabilistic analysis of safety) model and preparing the technical basis.

DEFF Research Database (Denmark)

BACKGROUND AND AIM OF THE STUDY: Abnormal flow conditions across aortic bioprosthetic valves may result in degenerative processes. Thus, it is important to implant biological valve prostheses with velocity profiles similar to those of native valves. The study aim was to compare blood velocity and velocity gradient profiles downstream of stented and stentless aortic valves implanted in pigs, and in native porcine valves. METHODS: Stented valve prostheses (Mitroflow, n = 7) or stentless valve prostheses (Solo, n = 5 or Toronto SPV, n = 7) were implanted into pigs; the native valve was retained in eight animals. After weaning the animals from cardiopulmonary bypass, cardiac magnetic resonance imaging was performed to determine the blood velocities and velocity gradient profiles. RESULTS: The native valves had a significantly lower peakvelocity (92 +/- 26 cm/s) than the artificial valves (Solo: 247 +/- 107 cm/s; Toronto: 252 +/- 41 cm/s; Mitroflow: 229 +/- 18 cm/s). ...

British Library Electronic Table of Contents (United Kingdom)

This paper explores the potential of combining substance-flow modelling with water and wastewater sampling to trace consumption-related substances emitted through the urban wastewater. The method is exemplified on sucralose. Sucralose is a chemical sweetener that is 600 times sweeter than sucrose and has been on the European market since 2004. As a food additive, sucralose has recently increased in usage in a number of foods, such as soft drinks, dairy products, candy and several dietary products. In a field campaign, sucralose concentrations were measured in the inflow and outflow of the local wastewater treatment plant in Linkoping, Sweden, as well as upstream and downstream of the receiving stream and in Lake Roxen. This allows the loads emitted from the city to be estimated. A method c...

British Library Electronic Table of Contents (United Kingdom)

Short synthetic single-stranded oligodeoxyribonucleotides (ssODNs) can be used to introduce subtle modifications into the genome of mouse embryonic stem cells (ESCs). We have previously shown that effective application of ssODN-mediated gene targeting in ESC requires (transient) suppression of DNA mismatch repair (MMR). However, whereas transient down-regulation of the mismatch recognition protein MSH2 allowed substitution of 3 or 4 nucleotides, 1 or 2 nucleotide substitutions were still suppressed. We now demonstrate that single- or dinucleotide substitution can effectively be achieved by transient down-regulation of the downstream MMR protein MLH1. By exploiting highly specific real-time PCR, we demonstrate the feasibility of substituting a single basepair in a non-selectable gene. Howev...

British Library Electronic Table of Contents (United Kingdom)

A promising drug target currently under investigation to improve cognitive deficits in neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine receptor (a7nAChR). Improving cognitive impairments in diseases such as Alzheimer's (AD) and schizophrenia remains a large unmet medical need, and the a7nAChR has many properties that make it an attractive therapeutic target. The a7nAChR is a ligand gated ion channel that has particularly high permeability to Ca^2^+ and is expressed in key brain regions involved in cognitive processes (e.g., hippocampus). The a7nAChRs are localized both pre-synaptically, where they can regulate neurotransmitter release, and post-synaptically where they can activate intracellular signaling cascades and influence downstream processes...

Energy Technology Data Exchange (ETDEWEB)

Greenhouse-effect induced climate change repercussions will, via the catchment areas of big rivers, eventually arrive in amplified form at the far downstream coastal zones of the world. In the coastal zone these imported problems will add to the locally exerted climate change effects, while the climate change induced sea-level rise will attack the coastal zone from the other side, both by flooding and by saline groundwater intrusion. These multiple problems will hit the coastal zone, which is already under increasing stress. The combined threats require fast and massive support for national Coastal Zone Management capabilities, which could help to limit the damage and to support planning for sustainable development. Recommendations are presented to facilitate implementation of Coastal Zone Management units in all coastal countries by the year 2000.

British Library Electronic Table of Contents (United Kingdom)

Bank sediments along a 40km reach of the South River, downstream of Waynesboro, VA, store mercury from historical contamination as a result of textile manufacturing. Knowledge of the rate at which contaminated sediment is released to the stream channel through bank erosion is required to implement restoration programs designed, for example, to minimize its ecological impact and to reduce risk to human health. Digitized stream channel boundaries based on visual interpretations of georeferenced aerial imagery from 1937 and 2005 were compared to calculate a minimum estimate of the total area of bank sediment eroded between Waynesboro and Port Republic, Virginia. Estimates of riverbank height were extracted from aerial LIDAR data, allowing areal estimates of bank retreat to be converted to vol...

International Nuclear Information System (INIS)

Macroparticle acceleration driven by low current, high voltage cathode spots has been investigated for potential applications ranging from micrometeoroid simulation to nanoparticle deposition/implantation. Acceleration by this process was observed to occur when nanometer and micrometer-sized particles were exposed to a high voltage pulse in the presence of a plasma discharge. The applied negative voltage pulse initiates the formation of multiple, high voltage, low current cathode spots which provide the mechanism of actual acceleration of the charged dust particles. Dust streams generated by this process were detected using laser scattering techniques. Cathode spot behavior was also documented. The particle impact craters observed at the surface of downstream witness badges were documented using scanning electron microscopy and light microscopy. The observed impacts suggest the presence of energetic macroparticles formed during this process.

Science.gov (United States)

Mixed convection in a rectangular channel (width/height = 2) with bottom-heated and top-cooled sections is studied by laser Doppler anemometry in nitrogen at Ra = 22,200 and Re = 18.75, 36, and 54. At the lower Re values, symmetry breaking is observed in steady but spatially oscillating flows that prevail over a certain distance from the leading edge of the differentially heated section. Further downstream, unsteady flows are found even for Re = 18.75. Numerical models are used to investigate the effects of adiabatic, conducting (with a conductive-convective heat transfer coefficient), and perfectly conducting side walls; channel tilts and Prandtl number dependence. Good agreement between calculations and experiment is obtained for longitudinal convective roll velocities. The transverse velocities are found to be independent of Re.

Energy Technology Data Exchange (ETDEWEB)

Adjustment of the rf phase in a linear accelerator is crucial for maintaining optimal performance. If phasing is incorrect, the beam will in general have an energy error and increased energy spread. While an energy error can be readily detected and corrected using position readings from beam position monitors at dispersion locations, this is not helpful for correcting energy spread in a system with many possible phase errors. Uncorrected energy spread results in poor capture efficiency in downstream accelerators, such as the Advanced Photon Source's (APS's) particle accumulator ring (PAR) or booster synchrotron. To address this issue, APS has implemented beam-to-rf phase detectors in the linac, along with software for automatic correction of phase errors. We discuss the design, implementation, and performance of these detectors and how they improved APS top-up operations.

Energy Technology Data Exchange (ETDEWEB)

Impacts of gas pipeline rights-of-way (ROWs) through wetlands depend on types of habitat, construction techniques, final elevations, ROW maintenance practices, soil composition, and local climate. In some instances factors unrelated to the presence of the pipeline may have greater impacts on wetland modification than does the pipeline itself. At one site, the required seeding program inhibited natural reestablishment of wetland plants; at another, downstream construction resulted in a major disruption to the adjacent wetland habitat. This paper discusses observation from 13 study sites, each zero to 30 years old, that are located in seven Eastern States.

International Nuclear Information System (INIS)

This paper describes the heat transfer augmentation and the flow situation around a single spacer (a cylindrical rod) on the heated surface of a parallel plate duct in order to examine basically the effects of the spacer in the fuel elements of a high temperature gas-cooled reactor. The ends of the cylindrical rod contact the upper and lower planes. A thermosensitive liquid crystal film is used to indicate the effective area for the heat transfer. The mean Nusselt number, which is estimated within the optional distance from the spacer to the downstream direction, peaks at a dimensionless distance of X/D = 1-3, and after that decreases gradually with the flow direction. The manner in which heat transfer corresponds to the flow situation is also examined. The horseshoe vortex, produced around the spacer, affects the wake and contributes to the increase of the local heat transfer. (author).

Energy Technology Data Exchange (ETDEWEB)

A new technique has been developed for the measurement of steam mass flowrate, water mass flowrate and total enthalpy of two-phase fluids produced from geothermal wells. The method involves precisely metered injection of liquid and vapor phase tracers into the two-phase production pipeline and concurrent sampling of each phase downstream of the injection point. Subsequent chemical analysis of the steam and water samples for tracer content enables the calculation of mass flowrate for each phase given the known mass injection rates of tracer. This technique has now been used extensively at the Coso geothermal project, owned and operated by California Energy Company. Initial validation of the method was performed at the Roosevelt Hot Springs geothermal project on wells producing to individual production separators equipped with orificeplate flowmeters for each phase.

International Nuclear Information System (INIS)

Purpose: To prevent structure material meltdown upon rupture of cooling pipeways in a impurity remover by preventing the coolants from flowing into the vacuum vessel while continuing the supply of coolants to other portions to be cooled. Constitution: Dual cooling pipeway systems are disposed to the neutralizing plates of the impurity remover. A rupture detector (pressure gage) is mounted to each of the cooling pipeways and flow rate control valves to be opened and closed by the signal from the detector are disposed to the upstream and downstream of the cooling pipeway. In this constitution if the cooling pipes should be ruptured, the coolant supply is stopped to the ruptured system in which the flow rate valve is closed by the signal from the rupture detector. However, since the coolant is kept to be supplied to the other system of the cooling pipeways, meltdown of the neutralizing plates can be prevented. (Kamimura, M.).

Energy Technology Data Exchange (ETDEWEB)

Biomass gasification provides the potential to efficiently and economically produce a renewable source of a clean gaseous fuel suitable for power generation or synthesis gas (syngas) applications. An important side benefit of the use of biomass is the effective minimization of the primary greenhouse gas, carbon dioxide (CO{sub 2}), by providing a means to close-loop the CO{sub 2} cycle. However, high molecular weight hydrocarbon constituents (tar) in the product gas from gasification can complicate the downstream uses of the gas. This paper discusses both the development of a low cost, disposable catalyst system that can eliminate these heavy hydrocarbons from the gas and the use of the catalyst in conjunction with the Battelle high-throughput gasification process for power generation and synthesis applications. (author)

Science.gov (United States)

In the Advance Coal Liquefaction Concept Proposal (ACLCP) carbon monoxide (CO) and water have been proposed as the primary reagents in the pretreatment process. The main objective of this project is to develop a methodology for pretreating coal under mild conditions based on a combination of existing processes which have shown great promise in liquefaction, extraction and pyrolysis studies. The aim of this pretreatment process is to partially depolymerise the coal, eliminate oxygen and diminish the propensity for retograde reactions during subsequent liquefaction. The desirable outcome of the CO pretreatment step should be: (1) enhanced liquefaction activity and/or selectivity toward products of higher quality due to chemical modification of the coal structure; (2) cleaner downstream products; (3) overall improvement in operability and process economics.

International Nuclear Information System (INIS)

Full text: Korea Atomic Energy Research Institute (KAERI) has many R and D facilities in operation. including HANARO research reactor, radioactive waste treatment facility (RWTF), post-irradiation examination facility (PIEF) and irradiated material test facility (IMEF). Recently. nation-wide interest is focused on the safety and security of major industrial facilities. Safe operation of nuclear facilities is imperative because of the consequence of public disaster by radiological release/contamination, in case of an accident. Recently, Ministry of Science and Technology (MOST) of the Korean government announced amendments of Atomic Energy laws to enforce requirements of the physical protection and radiological emergency. All provisions on nuclear safety regulation and radiation protection are entrusted to the Atomic Energy Act(AEA). The Act is enacted as the main law concerning the safety regulation of nuclear installations, and is supplemented by the Enforcement Decree and Enforcement ...

International Nuclear Information System (INIS)

Atomic Energy Regulatory Board carries out the regulatory review of the reactor physics design, commissioning and operational aspects through Project Design Safety Committee and Specialist Group of reactor physicists with wide experience in the design, commissioning and operational safety review of NPPs. TAPP-3 and 4 PHWRs, being the first indigenous design of 540 MWe Units, are quite different than the standard 220 MWe PHWRs. The safety review of reactor physics design was quite complex, as majority of the systems were new. The Reactor Physics Specialist Group carried out extensive safety review of 540 MWe PHWR reactor physics design and made significant contributions of design modifications and improvements in the operational procedures. Some salient contributions include: Monitoring the core during bulk addition of moderator without the availability of shutdown systems. Logics for providing safety cover in case of malfunction of SDS-1, Use ...

Energy Technology Data Exchange (ETDEWEB)

The Regulatory Agenda is a semiannual compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and of all petitions for rulemaking that the NRC has received that are pending disposition. The agenda consists of two sections that have been updated through June 30, 1997. Section 1, ``Rules,`` includes (A) rules on which final action has been taken since December 31, 1996, the closing date of the last NRC Regulatory Agenda; (B) rules published previously as proposed rules on which the Commission has not taken final action; (C) rules published as advance notices of proposed rulemaking for which neither a proposed nor final rule has been issued; and (D) unpublished rules on which the NRC expects to take action. Section 2, ``Petitions for Rulemaking,`` includes (A) petitions denied or incorporated into final rules since December 31, 1996; (B) petitions incorporated into proposed rules; ...

International Nuclear Information System (INIS)

The US Department of the Army, Baltimore District Corps of Engineers, oversees a long-term monitoring study to assess and evaluate effects of the Jennings-Randolph reservoir on biota in the North Branch Potomac River. The reservoir was intended, in part, to mitigate effects of acid mine drainage originating in upstream and headwater area. The present study assessed recovery of benthos and fish in this system, six years after completion of the reservoir. Higher pH and lower iron and sulfate concentrations were observed upstream of the reservoir compared to preimpoundment conditions, suggesting better overall water quality in the upper North Branch. Water quality improved slightly directly downstream of the reservoir. However, the reservoir itself was poorly colonized by macrophytes and benthic organisms, and plankton composition suggested either metal toxicity and/or nutrient limitation. One large tributary to the North Branch and the reservoir (Stony River) was ...

Energy Technology Data Exchange (ETDEWEB)

Rotary screw traps, located at four sites in the Grande Ronde River basin, were used to characterize aspects of early life history exhibited by juvenile Onchorhychus mykiss during migration years 1995-99. The Lostine, Catherine Creek and upper Grande Ronde traps captured fish as they migrated out of spawning areas into valley rearing habitats. The Grande Ronde Valley trap captured fish as they left valley habitats downstream of Catherine Creek and upper Grande Ronde River rearing habitats. Dispersal downstream of spawning areas was most evident in fall and spring, but movement occurred during all seasons that the traps were fished. Seaward migration occurred primarily in spring when O. mykiss smolts left overwintering area located in both spawning area and valley habitats. Migration patterns exhibited by O. mykiss suggest that Grande Ronde Valley habitats are used for overwintering and should be considered critical rearing habitat. We were ...

Energy Technology Data Exchange (ETDEWEB)

In this study, nanoparticle penetration was measured with a wide range of filter media using silver nanoparticles from 3 nm to 20 nm at three different face velocities in order to define nanoparticle filtration characteristics of commercial fibrous filter media. The silver particles were generated by heating a pure silver powder source via an electric furnace with a temperature of 870 deg. C, which was found to be the optimal temperature for generating an adequate amount of silver nanoparticles for the size range specified above. After size classification using a nano-DMA, the particle counts were measured by an Ultrafine Condensation Particle Counter (UCPC) both upstream and downstream of the test filter to determine the nanoparticle penetration for each specific particle size. Particle sampling time continued long enough to detect more than 10{sup 5} counts at the upstream and 10 counts at the downstream sampling point so that 99.99% ...

Energy Technology Data Exchange (ETDEWEB)

The Interstate Oil and Gas Compact Commission (IOGCC) engaged in numerous projects outlined under the scope of work discussed in the United States Department of Energy (DOE) grant number DE-FG26-01BC15336 awarded to the IOGCC. Numerous projects were completed that were extremely valuable to state oil and gas agencies as a result of work performed utilizing resources provided by the grant. There are numerous areas in which state agencies still need assistance. This additional assistance will need to be addressed under another grant because funding resources have been exhausted under The scope of work objectives for the eight projects covered under this grant is as follows: (1) Improve uniformity within state oil and gas data management efforts. (2) Conduct environmental compliance workshops and related educational projects on natural gas and oil exploration and production. (3) Improve regulatory efficiency through partnering opportunities provided by the Appalachian ...

Energy Technology Data Exchange (ETDEWEB)

This report summarizes a public workshop that was held on April 27, 1999, in Rockville, Maryland. The workshop was conducted as part of the US Nuclear Regulatory Commission's (NRC) efforts to further develop its understanding of the risks associated with low power and shutdown operations at US nuclear power plants. A sufficient understanding of such risks is required to support decision-making for risk-informed regulation, in particular Regulatory Guide 1.174, and the development of a consensus standard. During the workshop the NRC staff discussed and requested feedback from the public (including representatives of the nuclear industry, state governments, consultants, private industry, and the media) on the risk associated with low-power and shutdown operations.

Energy Technology Data Exchange (ETDEWEB)

This is the sixth report by the Advisory Committee on Reactor Safeguards (ACRS) that has been prepared in response to the Congressional requirement for an annual report on the Nuclear Regulatory Commission (NRC) Reactor Safety Research Program. Part I is a compilation of our general comments and recommendations regarding the NRC Safety Research Program, and includes budget recommendations and an identification of matters of special importance that deserve increased emphasis. It is intended to serve as an Executive Summary. Part II is divided into ten chapters, each of which represents a Decision Unit of the NRC research program. In each chapter, specific comments are included on the research involved in the Decision Unit, an assessment of priorities, and recommendations regarding new directions and levels of funding.

International Nuclear Information System (INIS)

Radioactive waste for legal and regulatory purposes may be defined as material that contains or is contaminated with radio-nuclides at concentrations or activities greater than clearance levels as established by the regulatory body, and for which no use is foreseen. Safe management of radioactive waste is essential to ensure protection of humans and environment. Radioactive waste management policy is a guideline for the safe management of radioactive waste. It expresses the commitment of the country towards the goal. Government should initiate investigation into best long-term option for management of spent nuclear fuels. Process of selecting option and eventual site should involve comprehensive public participation within set time frames (with deep geological disposal as preferred management option).

Energy Technology Data Exchange (ETDEWEB)

The Seabed Disposal Project (SDP) was evaluating the technical feasibility of high-level nuclear waste disposal in deep ocean sediments. Working standards were needed for risk assessments, evaluation of alternative designs, sensitivity studies, and conceptual design guidelines. This report completes a three part program to develop radiological standards for the feasibility phase of the SDP. The characteristics of subseabed disposal and how they affect the selection of standards are discussed. General radiological protection standards are reviewed, along with some new methods, and a systematic approach to developing standards is presented. The selected interim radiological standards for the SDP and the reasons for their selection are given. These standards have no legal or regulatory status and will be replaced or modified by regulatory agencies if subseabed disposal is implemented. 56 refs., 29 figs., 15 tabs.

British Library Electronic Table of Contents (United Kingdom)

Introduction: Haploidentical transplantation, with extensive T cell depletion to prevent GvHD, is associated with a high incidence of infection-related deaths. The key challenge is to improve immune recovery with allogeneic donor T cells without triggering GvHD. As T regulatory cells (Tregs) controlled GvHD in pre-clinical studies, the present study evaluated the impact of an infusion of donor CD4/CD25 + Tregs, followed by an inoculum of donor mature T cells (Tcons) and positively immunoselected CD34 + cells in the setting of haploidentical stem cell transplantation. Patients and methods: Twenty-eight patients were enrolled in this study (22 AML; 5 ALL; 1 NHL). All received immunoselected Tregs (CliniMACS, Miltenyi Biotec) followed by positively immunoselected CD34 + cells together with Tc...

Energy Technology Data Exchange (ETDEWEB)

The need for efficient management of industrial chemical wastes, especially those considered hazardous or radioactive, is receiving increased attention in the United States. During the past five years, several federal laws have addressed the establishment of stronger programs for the control of hazardous and residual wastes. At a facility such as Oak Ridge National Laboratory (ORNL), an efficient waste management program is an absolute necessity to ensure protection of human health and compliance with regulatory requirements addressing the treatment and disposal of hazardous, nonhazardous, and radioactive wastes. This report highlights the major regulatory requirements under which the Laboratory must operate and their impact on ORNL facilities. Individual waste streams, estimates of quantities of waste, and current waste management operations are discussed.

British Library Electronic Table of Contents (United Kingdom)

Research and bioethical policies are increasingly seen to facilitate, rather than to impede, scientific progress. Bioethical structures, nonetheless, often fail to account for or to shape the specific social surrounds in which scientific research is conducted. In Taiwan, a perceived shortage in human biological donations threatens to hamper stem cell research progress. This paper considers the stalled national biobank project and the lack of a reliable embryo supply for stem cell research, and suggests that one must look beyond regulatory structures in seeking explanations for such shortages. Specific aspects of Taiwan's democratization and social changes combine with problematic relations between patients and physicians to shape the terrain upon which human biologicals are given or withhe...

British Library Electronic Table of Contents (United Kingdom)

Abstract Objective. Anti-TNF-a antibodies has been suggested to modulate regulatory T cell (Treg) percentages in rheumatoid arthritis, but results from studies of Crohn's disease (CD) are conflicting. We investigated dynamic changes of circulating Tregs in CD during treatment with the anti-TNF-a-antibody adalimumab (Humira, Abbott Laboratories A/S, Emdrupvej 28C, DK-2100 Copenhagen). Material and methods. Blood samples from 26 CD patients were analysed using flow cytometry before and 1 and 26 weeks after initiation of adalimumab treatment to determine the percentage of Tregs among CD4++ T cells. Results. In spite of a significant decline in disease activity scores and biochemical markers of inflammation, during the first week of treatment, we did not observe early modulating effects of ada...

Science.gov (United States)

Using the phasmid vector pSL5, the genomic DNA fragment of T. aquaticus YT1 which contained the thermostable DNA polymerase (Taq-polymerase) gene was cloned. The BglII fragment of this genome locus was subcloned in the BamHI site of the pUC19 plasmid. To optimize the Taq-polymerase gene expression in E. coli cells, the gene was cloned in the correct reading frame regarding the initiation ATG codon of the pPR-TGATG-1 expression vector. The gene expression in this vector was controlled by the phage lambda PR promoter and the temperature-sensitive phage lambda repressor. We used PCR to amplify the short 5'-end fragment of the Taq-polymerase gene coding for the part into which an artificial SacI site was introduced. This site has been used for cloning the PCR product into the pPR-TGATG-1 vector, and the missing gene part was cloned into the KpnI site of the PCR product from the natural cloned gene. The cells of the E. coli PVG-A1 strain, which was obtained in the end, expressed efficiently ...

Energy Technology Data Exchange (ETDEWEB)

The centromere is the most characteristic landmark of eukaryotic chromosomes. Centromeres function as the site for kinetochore assembly and spindle attachment, allowing for the faithful pairing and segregation of sister chromatids during cell division. Characterization of centromeric DNA is not only essential to understand the structure and organization of plant genomes, but it is also a critical step in the development of plant artificial chromosomes. The centromeres of most model eukaryotic species, consist predominantly of long arrays of satellite DNA. Determining the precise DNA boundary of a centromere has proven to be a difficult task in multicellular eukaryotes. We have successfully cloned and sequenced the centromere of rice chromosome 8 (Cen8), representing the first fully sequenced centromere from any multicellular eukaryotes. The functional core of Cen8 spans ~800 kb of DNA, which was determined by chromatin immunoprecipitation (ChIP) using an antibody ...

Energy Technology Data Exchange (ETDEWEB)

Stargardt`s disease is inherited as an autosomal recessive condition characterized by a juvenile macular dystrophy. Genetic linkage analysis recently assigned the disease locus to chromosome 1p21-p13 with the best estimate for location of the gene near the locus D1S435. We performed linkage analysis in 34 North American families and 2 inbred families from the Kingdom of Saudi Arabia with 12 highly polymorphic markers on chromosome 1p flanking D1S435 between D1S207 and D1S223 and report significant linkage for all 12 markers with no evidence for genetic heterogeneity. Two-point linkage analysis demonstrated the Stargardt`s disease locus and D1S435 are linked with a maximum lod score of 17.17 at a recombination fraction of 1%. The markers UT851, D1S188, D1S424, UT2069, and D1S236 also demonstrated recombination fractions of 1% or less with two-point lod scores of 15.86, 21.93, 16.41, 20.36, and 17.37, respectively. To characterize this region further, fifty-five YACs with an average ...

Science.gov (United States)

The Drosophila sequence-specific DNA binding protein, Adf-1, is capable of activating transcription of the alcohol dehydrogenase gene, Adh, and is implicated in the transcriptional control of other developmentally regulated genes. We have cloned the cDNA encoding Adf-1 by generating specific DNA probes deduced from partial amino acid sequence of the protein. Several cDNA clones encoding an extended open reading frame were isolated from a phage lambda library. The complete amino acid sequence of Adf-1 deduced from the longest cDNA reveals structural similarities to the putative helix-turn-helix DNA binding motif of Myb and Myb-related proteins. DNA sequence analysis of genomic clones and Northern blot analysis of mRNA suggest that Adf-1 is a single-copy gene encoding a 1.9-kb transcript. Purified recombinant Adf-1 expressed in Escherichia coli binds specifically to Adf-1 recognition sites and activates transcription of a synthetic Adh promoter in vitro in a manner ...

Energy Technology Data Exchange (ETDEWEB)

Protection of wetlands became a national issue in 1988 when President George Bush pledged no net loss of wetlands in the US under his [open quotes]environmental presidency.[close quotes] As wetlands became a national issue, the job of protecting them became an obligation for many groups, including hydro-power developers. Now, when a site selected for development includes an area that may be classified as a wetland, the developer quickly discovers the importance of recognizing and protecting these natural habitats. Federal legislation severely limits development of wetland, and most states increase the restrictions with their own wetlands regulations. The difficulty of defining wetlands complicates federal and state enforcement. Land that appears to be dry may in fact be classified as a wetland. So, even if a site appears dry, potential hydro developers must confirm whether or not any jurisdictional wetlands are present. Regulated lands include much more than marshes and swamps. Further ...

UK PubMed Central (United Kingdom)

The cell cycle-regulatory transcription factor E2F-1 is regulated by interactions with proteins such as the retinoblastoma gene product and by cell cycle-dependent alterations in E2F-1 mRNA abundance....Full Text Available

International Nuclear Information System (INIS)

This report presents criteria for the identification and evaluation of fire hazards in nuclear power stations. The report presents criteria that are consistent with the existing regulatory approach in Canada, and outlines engineering tools and analytical techniques currently available to deterministically analyse fire. The criteria presented cover the topics which should be included in a fire hazard analysis and provide details of each topic so that the accuracy of an analysis may be evaluated.

International Nuclear Information System (INIS)

In this study, for the institutionalization of risk informed and performance based regulation in Korea, the latest technical movements of overseas countries are examined and reviewed. And the issues that was found when license change petition using risk information was submitted in Korean regulatory body are reviewed. Based on these review, the applicable areas to domestic situation will be found and proposed. This study can contribute to setting up the proper direction for the institutionalization of risk informed and performance based regulation

International Nuclear Information System (INIS)

The FFTF is an ERDA facility which does not require licensing, but a technical review by NRC is required by ERDA policy. Safety issues which were not fully resolved in the course of the review for construction authorization have been the subject of continuing review since mid-1973. These issues included HCDA energetics, design fallback provisions for additional safety margins, piping integrity, and natural circulation core cooling.

UK PubMed Central (United Kingdom)

We demonstrate that expression of the UGA1, CAN1, GAP1, PUT1, PUT2, PUT4, and DAL4 genes is sensitive to nitrogen catabolite repression. The expression of all these genes, with the exception of UGA1...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This journal includes all formal reports in the NUREG series prepared by the NRC staff and contractors, as well as proceedings of conferences and workshops. The entries in the compilation are indexed for access by title and abstract, contractor report number, personal author, subject, NRC organization, contractor, and licensed facility.

Energy Technology Data Exchange (ETDEWEB)

This Radioactive and Mixed Waste Management Plan for the Hazardous Waste Handling Facility at Lawrence Berkeley Laboratory is written to meet the requirements for an annual report of radioactive and mixed waste management activities outlined in DOE Order 5820.2A. Radioactive and mixed waste management activities during FY 1994 listed here include principal regulatory and environmental issues and the degree to which planned activities were accomplished.

Environmental Research Database

DescriptionThe recent sequencing of the complete genomes of several streptomycete species revealed the presence of a large number of cryptic' secondary metabolic gene clusters, and led to the realisation that these organisms have the ability to produce many more natural products than had previously been recognised. One of the aims of our work is to identify the physiological signals and regulatory mechanisms responsible for the activation of these 'cryptic' pathways, thus unleashing the full biosynthetic p [continued...

Energy Technology Data Exchange (ETDEWEB)

This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Directors' Decisions (DD), and the Denials of Petitions For Rulemaking (DPRM).

Energy Technology Data Exchange (ETDEWEB)

This report includes the issuances received during November, 1983, from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Directors' Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM).

Energy Technology Data Exchange (ETDEWEB)

The report presents selected highlights of how research has contributed to the regulatory effort. It explains the research role of the NRC and nuclear safety research contributions in the areas of: pressure vessel integrity, piping, small- and large-break loss-of-coolant accidents, hydrogen and containment, source term analysis, seismic hazards and high-level waste management. The report also provides a summary of current and future research directions in support of regulation.

UK PubMed Central (United Kingdom)

The yeast phosphatidylinositol transfer protein (Sec14p) is required for biogenesis of Golgi-derived transport vesicles and cell viability, and this essential Sec14p requirement is abrogated by inactivation...Full Text Available

Science.gov (United States)

Hox genes encode a family of transcriptional regulators that operate differential developmental programs along the anteroposterior axis of bilateral animals. Regulatory changes affecting Hox gene expression are believed to have been crucial for the evolution of animal body plans. In Drosophila melanogaster, Hox expression is post-transcriptionally regulated by microRNAs (miRNAs) acting on target sites located in the 3' untranslated regions (3'UTRs) of Hox mRNAs. Notably, recent work has shown that during D. melanogaster development Hox genes produce mRNAs with variable 3'UTRs (short and long forms) in different sets of tissues as a result of alternative polyadenylation; importantly, Hox short and long 3'UTRs contain very different target sites for miRNAs. Here, we use a computational approach to explore the evolution of Hox 3'UTRs treated with especial regard to miRNA regulation. Our work is focused on the 12 Drosophila species for which genomic sequences are ...

Science.gov (United States)

The Economic Analysis (EA) report is written to address the impacts of this proposed Effluent Limitation Guidelines and Standards for Synthetic-Based and Other Non-Aqueous Drilling Fluids. Currently, effluent guidelines pertaining to the discharge of drilling fluids address two specific types of fluids: Oil-based drilling fluids (OBFs) that use diesel and mineral oil, which are prohibited from being discharged; and Water-based drilling Fluids (WBFs), which can be discharged subject to meeting certain discharge requirements, including a sheen test and an aqueous toxicity test, in certain limited offshore regions. Section Two presents sources of data, Section Three presents the industry profile, Section Four discusses the regulatory costs of options under consideration for the proposed rulemaking, and Section Five discusses the impacts of the proposed rule on firms, well drilling, and production, and also briefly discusses secondary impacts such as those on ...

Energy Technology Data Exchange (ETDEWEB)

The UK Pipelines Safety Regulations require the pipeline operator to ensure that a pipeline, once decommissioned, does not become a source of danger. Elsewhere, Regulatory Authorities require consideration of the possible issues which pipeline decommissioning may raise. This paper considers current practice with respect to pipeline decommissioning and abandonment, and sets out the range of factors which the operator must take into account. (author)

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared

UK PubMed Central (United Kingdom)

In Borrelia burgdorferi (Bb), the Lyme disease spirochete, the alternative σ factor σ⁵⁴ (RpoN) directly activates transcription of another alternative σ...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundAberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This Pollution Prevention Design Assessment (PPDA) provides data for cost-benefit analysis of the potential environmental impact of the APT, is an integral part of pollution prevention/waste minimization, and is required by DOE for any activity generating radioactive, hazardous, and mixed wastes. It will also better position the APT to meet future requirements, since it is anticipated that regulatory and other requirements will continue to become more restrictive and demanding.

Energy Technology Data Exchange (ETDEWEB)

Significant environmental issues and regulatory proceedings in Alberta were discussed. The Mackenzie Valley Pipeline Project was reviewed in relation to the Deh Cho First Nation's advanced actions in the federal court to enjoin the review panel from proceeding with the review process. The Deh Cho First Nation is seeking a declaration that the plan violates their rights under the Canadian Charter of Rights and Freedoms and the Constitution Act. Various regulatory and government agencies have now developed a plan to coordinate their different regulatory processes and approvals in the Cooperation Plan for the Environmental Impact Assessment and Regulatory Review of the Northern Gas Pipeline project. The Deh Cho allege that they were not afforded the opportunity to participate in the development and implementation of the plan. A review panel plans to proceed once the environmental and social ...

International Nuclear Information System (INIS)

Velocity field behind a flat plate, placed near the wall in a narrow channel as a simulant of a BWR fuel spacer, was measured by using a hot wire anemometer. It was found that not only the positions where the dead water region behind flat plate disappeared but also the locations where the velocity relaxation completed were almost independent of the width of the clearance, although the local average velocity and velocity fluctuation immediately downstream the flat plate were affected by the difference in the clearance. The transverse flow diversions in the channel cross section were evaluated from the shape of the average velocity profile. The decrease of local flow rate near the channel wall, which may causes the drift flow behind a flat plate, was encouraged as the drag of clearance increased. Attempts have been made to measure spanwise velocity in the narrow channel. A spanwise velocity that occurred due to flow diversion was observed and its magnitude reached ...

Energy Technology Data Exchange (ETDEWEB)

The Ministere des Ressources naturelles du Quebec (Quebec Natural Resources Department) implemented a remedial program to treat the waste rock pile at Wood Cadillac, located near Cadillac, in Abitibi, Quebec. The solutions proposed by INRS-Georessources and ENVIROCONSEIL are aimed at eliminating erosion and stabilizing the geochemical processes. Part of the proposed solution also included the use of a reducing trickling filter for the treatment of acid leachates, which also contain arsenic when exiting the waste rock pile. The trickling filter is composed of forest tailings in which the bacteria reduce the sulphates and stimulate the precipitation of arsenic into arsenic sulphates. This is a new treatment that was developed following laboratory experiments which demonstrated the feasibility of the process and quantified the parameters. A demonstration unit was constructed by ENVIROCONSEIL and installed at the Wood Cadillac waste rock pile under the supervision of Dessau-Soprin. The ...

Energy Technology Data Exchange (ETDEWEB)

This decision document presents the selected remedial action for the Westerly Wetlands, Northerly Wetlands, and Tar Patch Area at the Burnt Fly Bog Superfund Site. It addresses contaminated soil present on the three remaining contaminated areas on the Site, including the Westerly Wetlands, Northerly Wetlands, and Tar Patch Area. The major components of the selected remedy include: Excavation and off-site disposal of contaminated soil from the Northerly Wetlands; Excavation and off-site disposal of contaminated soil from the Tar Patch Area; Backfilling the excavated area in the Northerly Wetland and reestablishing wetlands; Backfilling the excavated area in the Tar Patch Area and creating wetlands; Provision of additional security fencing around the Westerly Wetlands, and the recording of a Deed Notice for the Westerly Wetlands, Northerly Wetlands, and Tar Patch Area; Monitoring of surface water and sediment in the Westerly Wetlands, surface water and sediment in the existing ...

Energy Technology Data Exchange (ETDEWEB)

Since fuel oil meeting the requirements of current petroleum products can be produced by SASOL F-T synthetic process, the manufacturing process of hydrocarbon fuel oil from the coal-derived synthesis gas, downstream processes are being successively investigated. Mobile M-gasoline, MTG, process which produces gasoline from the natural gas-derived synthesis gas through methanol went into commercial operation in New Zealand in 1986. Although the gasoline suffices the quality of commercial gasoline by both fixed bed and fluidized bed systems, the price and service life of catalyst and control of by-product durene must be improved. Any STG processes have not been completed yet and the yield and quality of gasoline are inferior to those of gasoline produced by the MTG process. Applying two-stage process, the STG process will be more economically effective.(21 refs, 4 figs, 10 tabs)

Energy Technology Data Exchange (ETDEWEB)

The objective of the Hanford Environmental Dose Reconstruction Project (HEDR) is to estimate the potential radiation doses received by people living within the sphere of influence of the Hanford Site. A potential critical pathway for human radiation exposure is through the consumption of waterfowl that frequent onsite waste-water ponds or through eating of fish, shellfish, and waterfowl that reside in/on the Columbia River and its tributaries downstream of the reactors. This document summarizes information on fish, shellfish, and waterfowl radiation contamination for samples collected by Hanford monitoring personnel and offsite agencies for the period 1945 to 1972. Specific information includes the types of organisms sampled, the kinds of tissues and organs analyzed, the sampling locations, and the radionuclides reported. Some tissue concentrations are also included. We anticipate that these yearly summaries will be helpful to individuals and organizations ...

International Nuclear Information System (INIS)

The objective of the Hanford Environmental Dose Reconstruction Project (HEDR) is to estimate the potential radiation doses received by people living within the sphere of influence of the Hanford Site. A potential critical pathway for human radiation exposure is through the consumption of waterfowl that frequent onsite waste-water ponds or through eating of fish, shellfish, and waterfowl that reside in/on the Columbia River and its tributaries downstream of the reactors. This document summarizes information on fish, shellfish, and waterfowl radiation contamination for samples collected by Hanford monitoring personnel and offsite agencies for the period 1945 to 1972. Specific information includes the types of organisms sampled, the kinds of tissues and organs analyzed, the sampling locations, and the radionuclides reported. Some tissue concentrations are also included. We anticipate that these yearly summaries will be helpful to individuals and organizations ...

Science.gov (United States)

Functional activation of {beta}-catenin/Tcf signaling plays an important role in early events in carcinogenesis. We examined the effect of naringenin against {beta}-catenin/Tcf signaling in gastric cancer cells. Reporter gene assay showed that naringenin inhibited {beta}-catenin/Tcf signaling efficiently. In addition, the inhibition of {beta}-catenin/Tcf signaling by naringenin in HEK293 cells transiently transfected with constitutively mutant {beta}-catenin gene, whose product is not phosphorylated by GSK3{beta}, indicates that its inhibitory mechanism was related to {beta}-catenin itself or downstream components. To investigate the precise inhibitory mechanism, we performed immunofluorescence, Western blot, and EMSA. As a result, our data revealed that the {beta}-catenin distribution and the levels of nuclear {beta}-catenin and Tcf-4 proteins were unchanged after naringenin treatment. Moreover, the binding activities of Tcf complexes to consensus DNA were not ...

International Nuclear Information System (INIS)

This paper presents an overview of issues related to surface water contamination arising from uranium mining activities in the Alligator Rivers Region (ARR) of northern Australia, and a program of research and monitoring that must assess the potential and actual effects on ecosystem and human health. The program of assessing effects on aquatic ecosystems involves a four-tiered approach including the derivation of local water quality guideline trigger values, direct toxicity assessment of mine waters prior to their release, creekside or in situ monitoring for early warning of adverse effects during mine water release, and longer-term monitoring of macroinvertebrate and fish communities. Bioaccumulation in aquatic biota is also assessed, and is an issue of importance not only to ecosystem health, but also to the health of local Aboriginal people. The aquatic animals they consume represent potential sources of radiological dose, and as a result, a major component of the program to assess ...

International Nuclear Information System (INIS)

Human erythrocyte glucose-6-phosphate is normally quite stable in the presence of 10 #mu#M NADP"+. Certain glucose-6-phosphate dehydrogenase variants lose virtually all their activity at this concentration of NADP"+ but are reactivated by 200 #mu#M NADP"+. Such variants presumably have a defect in their NADP"+-binding site. The authors analyzed the sequence of cDNA or genomic DNA from seven unrelated patients with hemolytic anemia due to the inheritance of variants that are reactivated by NADP"+. Six patients had substitutions of one of three adjacent amino acids, and the seventh patient had another amino acid substitution 23 residues downstream. These amino acids are highly conserved, all being present in rat and all but one being found also in Drosophila. The anomalous electrophoretic behavior of some of the variants can be explained by their loss of ability to bind NADP"+. The conclude that the region in which these mutations occur defines the binding domain for ...

Energy Technology Data Exchange (ETDEWEB)

Activated charcoal which is the desulfurizing agent for the fuel cell plant can be used only at the normal temperature, and it must be placed upstream of the fuel gas, increasing the displacement flow of the fuel gas processed in the desulfurizer. In addition, a large quantity of activated charcoal must be filled or the frequency of its exchange must be increased because activated charcoal used at the normal temperature has little sulfur absorbing capacity. This invention is concerned with provision of a desulfurizer in the downstream of the fuel gas compressor of the fuel cell plant to remove sulfur content in the fuel gas by this desulfurizer. As a result, the displacement flow of the processing gas is decreased to increase the processing capacity of the desulfurizing agent. In addition, hydrogen recycling can be eliminated to realize compact arrangement of the equipment and economization of energy consumption. Metal oxide based desulfurizers of copper, iron, ...

Science.gov (United States)

The GTPases comprise a protein superfamily of highly conserved molecular switches adapted to many diverse functions. These proteins are found in all domains of life and often perform essential roles in fundamental cellular processes. Analysis of data from genome sequencing projects demonstrates that bacteria possess a core of 11 universally conserved GTPases (elongation factor G and Tu, initiation factor 2, LepA, Era, Obg, ThdF/TrmE, Ffh, FtsY, EngA and YchF). Investigations aimed at understanding the function of GTPases indicate that a second conserved feature of these proteins is that they elicit their function through interaction with RNA and/or ribosomes. An emerging concept suggests that the 11 universal GTPases are either necessary for ribosome function or transmitting information from the ribosome to downstream targets for the purpose of generating specific cellular responses. Furthermore, it is suggested that progenitor GTPases were early regulators of RNA ...

Energy Technology Data Exchange (ETDEWEB)

In this study, the exhaust gas from a common-rail direct injection diesel engine was investigated both upstream and downstream warm-up catalytic converters (WCC). Three different types of ultra-low sulfur fuels (ethanol-diesel blend, ethanol-diesel blend with cetane improver and pure diesel) were tested in this study. The objective of the work was to study the engine performance and the formation of THC (total hydro carbon), CO (carbon monoxide), NO{sub x} (nitrogen oxides), smoke and PM (particulate matters) when using these fuels. THC and CO emissions of the ethanol-diesel blend fuels were slightly increased, and about 50-80% mean conversion efficiencies of THC and CO on catalysts were achieved in the ECE R49 13-mode cycle. Smoke was decreased by more than 42% in the entire ECE 13-mode cycles. From the measurement of scanning mobility particle sizer (SMPS) for the particle size range of 10-385 nm, the total number and total mass of the PM of the ethanol-diesel ...

Energy Technology Data Exchange (ETDEWEB)

This report describes a study to evaluate methods for locating leaks of dielectric fluid from buried high-voltage cable systems. Two primary types of leak location systems were investigated: (1) systems that will rapidly isolate the leak within a manhole section, typically 1000-m long on a feeder that might be 30-km long; and (2) systems that will then pinpoint the location of the leak. Rapid leak isolation was accomplished by developing an enhanced conductivity oil probe which allows the injection of a small quantity of conductive oil and which indicates the path of the oil as it drifts downstream in the direction of the leak. Two methods for pinpointing the leak were proven. The more successful method was the use of trained leak location dogs which were found to have far better sensitivity than instruments and which could detect cable oil alone without the need for additives. A tracer gas injection and detection scheme was developed for use in areas where the ...

Energy Technology Data Exchange (ETDEWEB)

Production of hydrogen sulfide in produced waters due to the activity of sulfate-reducing bacteria (SRB) is a potentially serious problem. The hydrogen sulfide is not only a safety and environmental concern, it also contributes to corrosion, solids formation, a reduction in produced oil and gas values, and limitations on water discharge. Waters produced from seawater-flooded reservoirs typically contain all of the nutrients required to support SRB metabolism. Surface processing facilities provide a favorable environment in which SRB flourish, converting water-borne nutrients into biomass and H{sub 2}S. This paper will present results from a field trial in which a new technology for the biochemical control of SRB metabolism was successfully applied. A slip stream of water downstream of separators on a produced water handling facility was routed through a bioreactor in a side-steam device where microbial growth was allowed to develop fully. This slip stream was then ...

International Nuclear Information System (INIS)

Macroinvertebrate communities in Rietvlei nature reserve wetland area and their relationship with water quality were studied with the aim to evaluate their use as potential indicators of pollution. Sampling locations were selected to include outlets from swage effluent, agricultural and informal residential runoff. A large increase in nutrient concentrations was observed downstream from discharged treated sewage with an associated decrease in species richness. Bioassays performed included: Daphnia magna, Hydra attenuate, Lactuca sativa, Allium cepa and Pyxicephalus adspersus. The highest percentage of lethality response to a screen (100% concentration) of sampled wetland water by test specimens were observed at the point source input of the Hartbeespoort treated sewage plant. Data generated from the AUSRIVAS method and multitrophic level bioassays revealed the deterioration of the wetland possibly due to factors such as increasing urbanization, industrialization, ...

International Nuclear Information System (INIS)

In 1990, field studies of water quality and stream macroinvertebrate communities were initiated in Sandia Canyon at Los Alamos National Laboratory. The studies were designed to establish baseline data and to determine the effects of routine discharges of industrial and sanitary waste. Water quality measurements were taken and aquatic macroinvertebrates sampled at three permanent stations within the canyon. Two of the three sample stations are located where the stream regularly receives industrial and sanitary waste effluents. These stations exhibited a low diversity of macroinvertebrates and slightly degraded water quality. The last sample station, located approximately 0.4 km (0.25 mi) downstream from the nearest wastewater outfall, appears to be in a zone of recovery where water quality parameters more closely resemble those found in natural streams in the Los Alamos area. A large increase in macroinvertebrate diversity was also observed at the third station. ...

International Nuclear Information System (INIS)

The inducible transcription factor NF-#kappa#B regulates divergent signaling pathways including inflammatory response and cancer development. Selective inhibitors for NF-#kappa#B signaling are potentially useful for treatment of inflammation and cancer. NF-#kappa#B is canonically activated by preferential disposal of its inhibitory protein; I#kappa#B, which suppresses the nuclear translocation of NF-#kappa#B. I#kappa#B#alpha# (a major member of I#kappa#B family proteins) is phosphorylated with an I#kappa#B kinase (IKK) and subsequently polyubiquitylated by SCF"#beta#"T"r"C"P"1 ubiquitin-ligase in the presence of E1 and E2 prior to proteasomal degradation. Here, we describe a novel inhibitor termed GS143, which suppressed I#kappa#B#alpha# ubiquitylation, but not I#kappa#B#alpha# phosphorylation, MDM2-directed p53 ubiquitylation, and proteasome activity in vitro. GS143 markedly suppressed the destruction of I#kappa#B#alpha# stimulated by TNF#alpha# and a set of ...

Energy Technology Data Exchange (ETDEWEB)

Typical beam lines are comprised of an assembly of vacuum valves and shutters referred to as a ''front end'', optical elements to monochromatize, focus and split the photon beam, and an experimental area where a target sample is placed into the photon beam and data from the interaction is detected and recorded. Windows are used to separate sections of beam lines that are not compatible with storage ring ultra high vacuum. Some experimental beam lines share a common vacuum with storage rings. Sections of beam lines are only allowed to vent up to atmospheric pressure using pure nitrogen gas after a vacuum barrier is established to protect ring vacuum. The front end may only be bled up when there is no current in the machine. This is especially true on the VUV storage ring where for most experiments, windows are not used. For the shorter wavelength, more energetic photons of the x-ray ring, beryllium windows are used at various beam line locations so ...

Energy Technology Data Exchange (ETDEWEB)

The Center for Nuclear Waste Regulatory Analyses organized and hosted a workshop on ``Rock Mechanics Issues in Repository Design and Performance Assessment`` on behalf its sponsor the U.S. Nuclear Regulatory Commission (NRC). This workshop was held on September 19- 20, 1994 at the Holiday Inn Crowne Plaza, Rockville, Maryland. The objectives of the workshop were to stimulate exchange of technical information among parties actively investigating rock mechanics issues relevant to the proposed high-level waste repository at Yucca Mountain and identify/confirm rock mechanics issues important to repository design and performance assessment The workshop contained three technical sessions and two panel discussions. The participants included technical and research staffs representing the NRC and the Department of Energy and their contractors, as well as researchers from the academic, commercial, and international technical communities. These ...

Energy Technology Data Exchange (ETDEWEB)

This is the eighth report by the Advisory Committee on Reactor Safeguards (ACRS) that has been prepared in response to the Congressional requirement for an annual report on the Nuclear Regulatory Commission (NRC) Reactor Safety Research Program. As previously requested by the Congress, the timing of this report has been adjusted to enable the ACRS to address the proposed budget for FY 1986 and 1987 that has been submitted to the Congress by the President. Detailed comments and recommendations are provided for the research programs and budget proposed for FY 1986. Because both the budget for FY 1987 and the research programs for that period are highly uncertain at this time, comments on these are not provided. Part I is a compilation of general comments and recommendations regarding the NRC Safety Research Program budget for FY 1986. It is intended to serve as the Executive Summary. Part II is divided into five chapters, each of which represents a Decision Unit of ...

Energy Technology Data Exchange (ETDEWEB)

In 1982 the semi-submersible drilling unit Ocean Ranger capsized and sank off the Grand Banks, resulting in the loss of the entire 84-man crew. A Royal Commission was set up to conduct an enquiry into the incident, and to carry out a process of research and opinion-gathering towards providing recommendations to both federal and Newfoundland governments. The primary purpose of the Commission was to determine why the Ocean Ranger sank, why none of the crew were saved, and how to avoid similar disasters. A number of studies and seminars were held to focus expert knowledge and opinion in several key fields and to update studies and fill gaps in the data base. Summaries of selected study reports and the seminar proceedings are presented in the following areas: the environment, including ice, marine climatology, weather forecasting services, wave climatology, oceanographic information, and seabed information; design, including mobile offshore drilling rig design evolution, continuity from ...

International Nuclear Information System (INIS)

Computer based control systems for safety related applications in nuclear power plants have to meet not only the functional, performance and interface requirements, they in addition, have to meet regulatory requirements like enhanced reliability, safety and security and should provide fault tolerance, diagnostics and self-supervision. The control system architecture, hardware design and software design should meet requirements as specified in design code and guides of AERB. The Dual Processor Hot Standby Process Control System (DPHS-PCS) for TAPP-3 and 4 is a safety related (Class- IB) system. DPHS-PCS regulates PHT pressure, Pressuriser pressure, Pressuriser level, Bleed condenser pressure, Bleed condenser level and Steam generator pressure. The performance, reliability and safety requirements of this control system are met by employing a fault tolerant computer configuration developed for this purpose using hardware designed with facility for on-line diagnostics ...

Energy Technology Data Exchange (ETDEWEB)

The electricity industry in the US today is at a crossroads. The restructuring debate going on in most regions has made it clear that the traditional model of vertically integrated firms serving defined franchise areas and regulated by state commissions may not be the pattern for the future. The demands of large customers seeking direct access to power markets, the entry of new participants, and proposed reforms of the regulatory process all signify a momentum for fundamental change in the organization of the industry. This paper addresses electricity restructuring from the perspective of bulk power markets. The authors focus attention on the organization of electricity trade and the various ways it has been and might be conducted. Their approach concentrates on conceptual models and empirical case studies, not on specific proposals made by particular utilities or commissions. They review literature in economics and power system engineering that is relevant to the ...

Energy Technology Data Exchange (ETDEWEB)

This study examines, in general, the transformation of the role of the Brazilian state to intervener in supervisory of the services, through the delegation of responsibility for the exploitation of public services to private enterprise, and the creation of regulatory agencies. The study pointing to the necessity of a legal and regulatory stable scenario in the regulation of these services, as enables of private investment mechanisms and, as a consequence of sustainable economic development. The success of the neo liberal state model is examined, specifically in relation to the market of pipeline gas distribution, showing the environmental, economic and social benefits that brought in this sector, the private investment and stability so far reasonably observed in this segment. The work also indicating, in general, the risks and issues most relevant, from the investor and markets point of view, to attract and maintain investment and to reduce the ...

Energy Technology Data Exchange (ETDEWEB)

In the RIR (Risk-informed Regulation), PSA (Probabilistic Safety Assessment) plays a major role because it provides overall risk insights for the regulatory body and utility. Therefore, the scope, the level of details and the technical adequacy of PSA, i.e. the quality of PSA is to be ensured for the successful RIR. To improve the quality of Korean PSA, we evaluate the quality of the KSNP (Korean Standard Nuclear Power Plant) internal full-power PSA model based on the 'ASME PRA Standard' and the 'NEI PRA Peer Review Process Guidance.' As a working group, PSA experts of the regulatory body and industry also participated in the evaluation process. It is finally judged that the overall quality of the KSNP PSA is between the ASME Standard Capability Category I and II. We also derive some items to be improved for upgrading the quality of the PSA up to the ASME Standard Capability Category II. In this paper, we ...

Energy Technology Data Exchange (ETDEWEB)

We report here a study of the mechanisms leading to loss of growth control in chicken embryo fibroblasts transformed by Rous sarcoma virus (RSV). We have been particularly concerned with the role of the src gene in this process, and have used RSV mutants temperature sensitive (ts) for transformation to investigate the nature of the growth regulatory lesion. The two principal findings were (1) the stationary phase of the cell cycle (G{sub 1}) in chick embryo fibroblasts seems to have two distinct regulatory compartments (using the terminology of Brooks et al. we refer to these as 'Q' and 'A' states). When rendered stationary at 41.5 C by serum deprivation, normal cells enter a Q state, but cells infected with the ts-mutant occupy an A state. (2) Whereas normal cells can occupy either state depending on culture conditions, the ts-infected cells, at 41.5 C, do not seem to enter Q even though a known src gene ...

International Nuclear Information System (INIS)

This regulatory guide describes methods acceptable to the NRC staff for calculating radon fluxes through earthen covers and for calculating the resulting minimum cover thickness needed to meet NRC and EPA standards. The guide also suggests methods for obtaining the various parameters used in calculating the radon fluxes and earthen cover thicknesses and suggests default values for certain parameters. This regulatory guide is applicable to active uranium tailings sites. The NRC staff is using the methods stated in this guide as a basis for review and concurrence of DOE remedial action plans for inactive sites. The guidance is intended to be used for calculating radon flux attenuation by earthen uranium mill tailings covers. The parameter values and examples presented are limited to earthen cover materials, but the diffusion theory and the methods presented are also applicable to man-made materials. Detailed supporting information for calculating ...

Energy Technology Data Exchange (ETDEWEB)

Following the unexpected, but safely terminated, power and flow oscillations in the LaSalle-2 Boiling Water Reactor (BWR) on March 9, 1988, the Nuclear Regulatory Commission (NRC) Offices of Nuclear Reactor Regulation (NRR) and of Analysis and Evaluation of Operational Data (AEOD) requested that the Office of Nuclear Regulatory Research (RES) carry out BWR stability analyses, centered around fourteen specific questions. Ten of the fourteen questions address BWR stability issues in general and are dealt with in this paper. The other four questions address local, out-of-phase oscillations and matters of instrumentation; they fall outside the scope of the work reported here. It was the purpose of the work documented in this report to answer ten of the fourteen NRC-stipulated questions. Nine questions are answered by analyzing the LaSalle-2 instability and related BWR transients with the BNL Engineering Plant Analyzer (EPA) and by performing an ...

Energy Technology Data Exchange (ETDEWEB)

A brief overview is given of the geological characteristics of each region of the state as they relate to potential geothermal development. Those exploration methods which can lead to the siting of a deep exploration well are described. Requirements and techniques needed for drilling deeper higher temperature exploration and production wells are presented. Electrical generation, direct utilization, and indirect utilization are reviewed. Economic factors of direct use projects are presented. A general guide to the regulatory framework affecting geothermal energy development is provided. The general steps necessary to gain access to explore, develop, distribute, and use geothermal resources are outlined. (MHR)

Energy Technology Data Exchange (ETDEWEB)

The University of California at Los Angeles (UCLA) participated in a U.S. Nuclear Regulatory Commission research program to investigate methods to measure the effect of management and organization on nuclear plant safety. The UCLA research team focused its efforts on understanding {open_quotes}deep technical knowledge,{close_quotes} and its relation to probabilistic risk assessment. As a result, the research team combined deep technical knowledge with a commonly used rating system for understanding the effectiveness of management and organizations.

British Library Electronic Table of Contents (United Kingdom)

The mammalian circadian timing system is organized into hierarchical structures with a central clock in the suprachiasmatic nucleus (SCN) and subsidiary peripheral oscillators. After the discovery of the local clockwork in peripheral organs and tissues, which have a molecular makeup similar to the central pacemaker SCN, uncovering the roles of the peripheral clock in the rhythmic physiology has been an emerging goal in chronobiology. Glucocorticoid (GC) is a multifunctional adrenal steroid hormone that shows a robust circadian rhythm. The daily GC rhythm has long been thought to be governed by the SCN via the hypothalamus-pituitary-adrenal neuroendocrine axis. Recent findings, however, indicate that multiple regulatory mechanisms, including the adrenal intrinsic mechanism by the peripheral...

International Nuclear Information System (INIS)

The author describes the history of the Soviet Unions nuclear weapons testing in Siberia from the first bomb on 29th August 1949 until the test-ban treaty of 1963. The effects of the weapons testing on the local population is only now becoming widely known. Levels of cancers and cataracts are significantly higher than in uneffected populations, and there are also high levels of some lung, bone, skin and digestive conditions. Perhaps the most important information relates to cataracts, previously thought to be caused by single large bursts of radiation. Regulatory authorities worldwide will need to tighten the safety limits for eye radiation exposure to these findings. (U.K.).

Energy Technology Data Exchange (ETDEWEB)

A respected veteran among state utility regulators raises a sober warning that it may not be possible for the telecommunications industry to survive half regulated and half unregulated, which is its posture for the present. He foresees a danger that the unregulated sector may be successful in capturing all the profitable portions of the market, leaving only the unprofitable areas to the regulated sector, which will then experience serious dislocations and even system breakdowns. Avoidance of such an outcome to the deregulatory steps presently being taken will require an uncommon degree of prudence and wisdom in those state officials who remain charged with regulatory responsibility for local exchange telephone facilities and service.

Energy Technology Data Exchange (ETDEWEB)

In order to realize improve of reliability and economy by duplicate production, rapid supply of repair parts from standardized storage, such were expected as to have continuous order of standardized plant, to ignore site condition, to avoid expansion of regulatory requirement. Standardization program was planned to limitedly promote standardization of safety-related design concept, major specification and basic system composition of reactor and primary systems. The area of standardization had been tried to expand to BOP such as general arrangement and rad-waste system.

Energy Technology Data Exchange (ETDEWEB)

The Conawapa-Winnipeg Power Transmission Complex includes five interrelated transmission and conversion facilities. This booklet describes work done on the upgrade of the southern receiver system, one component of the complex. The southern receiver system is composed of a network of high voltage transmission lines and station facilities. The booklet includes a description of the upgrade, the project setting, short and long-term effects and impact management, and the next steps to be taken in the process, including the regulatory process and public consultation.