UK PubMed Central (United Kingdom)

Campylobacter is one of the leading causes of food-borne gastroenteritis and has a high prevalence in poultry. Campylobacter jejuni subsp. jejuni 327 is a subspecies...Full Text Available

UK PubMed Central (United Kingdom)

In this work we conducted both in vitro and in vivo experiments to examine the development and mechanisms of erythromycin (Ery) resistance in Campylobacter jejuni and Campylobacter...Full Text Available

Science.gov (United States)

... The program generates conceptual layouts of wing structural components and creates a beam finite element model of the wing structure (Figure 6 ...

UK PubMed Central (United Kingdom)

A commercially available synthetic nucleic acid probe (SNAP) conjugated to alkaline phosphatase was compared with standard culture techniques for detecting Campylobacter species. The SNAP was able to...Full Text Available

UK PubMed Central (United Kingdom)

Advances in molecular technologies challenge the different concepts of causality in biology, epidemiology and multistage mathematical models. The lack of integration of the different aspects of causality...Full Text Available

Science.gov (United States)

Aug 18, 2004 ... The Arabian Gulf region presents a challenge to meteorologists trying to simulate weather with computer models because sea-surface and land ...

Energy Technology Data Exchange (ETDEWEB)

Transient Enhanced Diffusion (TED) is one of the biggest modeling challenges present in predicting scaled technologies. Damage from implantation of dopant ions changes the diffusivities of the dopants and precipitates to form complex extended defects. Developing a quantitative model for the extended defect behavior during short time, low temperature anneals is a key to explaining TED. This paper reviews some of the modeling developments over the last several years, and discusses some of the challenges that remain to be addressed. Two examples of models compared to experimental work are presented and discussed.

British Library Electronic Table of Contents (United Kingdom)

Abstract This study presents a review of distributed model predictive control (DMPC) strategies followed by recent studies conducted by the authors on the robustness of these strategies to model errors and a summary of future challenges in this area. The review identifies three key challenges for the successful application of DMPC: (i) the selection of optimal control structure for DMPC; (ii) the choice of a suitable coordination strategy among the controllers; and (iii) the robustness of DMPC strategies to model errors. Then, the study summarises recent developments related to the robustness of unconstrained and constrained DMPC algorithms. For the unconstrained case, a methodology that is based on the calculation of a performance index is proposed to balance the trade-off between perform...

Science.gov (United States)

Campylobacter spp. are present in the intestinal tract and internal tissues of broiler breeder and broiler chickens. Campylobacter spp. are known to cause acute bacterial gastroenteritis in humans and raw poultry products have been implicated as a significant source of these infections. The object...

UK PubMed Central (United Kingdom)

The recent introduction of several transposable elements in zebrafish opens new frontiers for genetic manipulation in this important vertebrate model. This review discusses transposable elements as...Full Text Available

UK PubMed Central (United Kingdom)

The treatment of brain disorders is one of the greatest challenges in drug delivery because of a variety of main barriers in effective drug transport and maintaining therapeutic concentrations in the...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The trend toward smaller dimensions in integrated circuit technology presents severe physical and engineering challenges for ion implantation. These challenges, together with the need for physically-based models at exceedingly small dimensions, are leading to a new level of understanding of fundamental defect science in silicon. Recently the DOE Council on Materials requested that our panel examine the current status and future research opportunities in the area of ion beams in semiconductor processing. Particularly interesting are the emerging approaches to defect and dopant distribution modeling, transient enhanced diffusion, high energy implantation and defect accumulation, and metal impurity gettering. These topics were explored both from the perspective of emerging science issues and technology challenges.

Science.gov (United States)

PMID:21956307

CERN Document Server

ScotGrid is a distributed Tier-2 centre in the UK with sites in Durham, Edinburgh and Glasgow. ScotGrid has undergone a huge expansion in hardware in anticipation of the LHC and now provides more than 4MSI2K and 500TB to the LHC VOs. Scaling up to this level of provision has brought many challenges to the Tier-2 and we show in this paper how we have adopted new methods of organising the centres, from fabric management and monitoring to remote management of sites to management and operational procedures, to meet these challenges. We describe how we have coped with different operational models at the sites, where Glagsow and Durham sites are managed "in house" but resources at Edinburgh are managed as a central university resource. This required the adoption of a different fabric management model at Edinburgh and a special engagement with the cluster managers. Challenges arose from ...

Science.gov (United States)

One of the goals of the DARPA Virtual Soldier Project is to aid the field medic in the triage of a casualty. In Phase I, we are currently collecting 12 baseline experimental physiological variables and a cardiac gated Computed Tomography (CT) imagery for use in an prototyping a futuristic electronic medical record, the "Holomer". We are using physiological models and Kalman filtering to aid in diagnosis and predict outcomes in relation to cardiac injury. The physiological modeling introduces another few hundred variables. Reducing the complexity of the above into easy-to-read text to aid in the triage by the field medic is the challenge with multiple display solutions. A description of the possible techniques follows. PMID:15718701

British Library Electronic Table of Contents (United Kingdom)

Abstract This article summarizes the results of a Nutrient Biomarker Study in the Women's Health Initiative, and its application to studies of the association between energy and protein consumption and the risk of major cancers and cardiovascular diseases. The presentation emphasizes measurement error modeling and related data analysis methods, since addressing measurement issues appears to be central to these topics and to progress in nutritional epidemiology more generally. The manner in which body mass index is modeled in disease association analysis is particularly challenging, since it could serve as a mediator or as a confounder of the association, and at the same time contributes valuably to energy and protein consumption assessment. A hazard ratio parameter estimation procedure tha...

CERN Document Server

Graphical Business Process Modelling Languages (BPML) like Role Activity Diagrams (RAD) provide ease and flexibility for modelling business behaviour. However, these languages show limited applicability in terms of enactment over distributed systems paradigms like Service Oriented Architecture (SOA) based grid computing. This paper investigates RAD modelling of a Scientific Publishing Process (SPP) for Digital Libraries (DL) and tries to determine the suitability of Pi-Calculus based formal approaches to enact SOA based grid computing. In order to achieve this purpose, the Pi-Calculus based formal transformation from a RAD model of SPP for DL draws attention towards a number of challenging issues including issues that require particular design considerations for appropriate enactment in a SOA based grid system.

Science.gov (United States)

The use of meta-analysis has become increasingly useful for clinical and policy decision making. A recent development in meta-analysis, multiple treatment comparison (MTC) meta-analysis, provides inferences on the comparative effectiveness of interventions that may have never been directly evaluated in clinical trials. This new approach may be confusing for clinicians and methodologists and raises specific challenges relevant to certain areas of medicine. This article addresses the methodological concepts of MTC meta-analysis, including issues of heterogeneity, choice of model, and adequacy of sample sizes. We address domain-specific challenges relevant to disciplines of medicine, including baseline risks of patient populations. We conclude that MTC meta-analysis is a useful tool in the context of comparative effectiveness and requires further study, as its utility and transparency will likely predict its uptake by the ...

Energy Technology Data Exchange (ETDEWEB)

Exceptional progress has been made in mathematical algorithm research leading to optimized mesh partitions for the highly unstructured grids occurring in finite element applications in solid mechanics. Today another research challenge presents itself. Research is needed to include boundary conditions into the algorithms for partitioning meshes. We describe below two methods we use currently to accomplish this and propose a more general approach be developed which would apply to our problems today as well as to the coupled models we envision for the future. Finally, we suggest research be considered that would incorporate partitioning methods into parallel mesh generation.

Energy Technology Data Exchange (ETDEWEB)

There is an ever increasing demand to perform flow simulations that incorporate the complete details of geometry as well as sophisticated flow physics. This has led to the development of numerical algorithms that can simulate the actual flow phenomena with greater fidelity. However, the success of these algorithms hinges on the grid that models the geometry. Grid generation methods for 2-D models have long existed and the general lack of complexity of the simpler 2-D models has not quite challenged the efforts in this area. However, demands for generating better 3-D geometric models for flow simulations involving complex geometries have completely changed the perspective of grid generation strategies. As a consequence, grid generation efforts have earned equal significance as that of numerical solver efforts.

Energy Technology Data Exchange (ETDEWEB)

In this paper we report on multi-physics, multi-billion macroparticle simulation of beam transport in a free electron laser (FEL) linac for future light source applications. The simulation includes a self-consistent calculation of 3D space-charge effects, short-range geometry wakefields, longitudinal coherent synchrotron radiation (CSR) wakefields, and detailed modeling of RF acceleration and focusing. We discuss the need for and the challenges associated with such large-scale simulation. Applications to the study of the microbunching instability in an FEL linac are also presented.

British Library Electronic Table of Contents (United Kingdom)

The involvement of dorsal root ganglia was studied in an in vivo model of experimental rabies virus infection using the challenge virus standard (CVS-11) strain. Dorsal root ganglia neurons infected with CVS in vitro show prolonged survival and few morphological changes, and are commonly used to study the infection. It has been established that after peripheral inoculation of mice with CVS the brain and spinal cord show relatively few neurodegenerative changes, but detailed studies of pathological changes in dorsal root ganglia have not previously been performed in this in vivo experimental model. In this study, adult ICR mice were inoculated in the right hindlimb footpad with CVS. Spinal cords and dorsal root ganglia were evaluated at serial time points for histopathological and ultrastru...

British Library Electronic Table of Contents (United Kingdom)

Introduction Alternative ways and means of transportation are necessary in order to reduce the environmental impacts of mobility. In the recent years, biofuels were first seen as a main option and then LCA showed also possible hazards of this development. Recently, public interest is rapidly shifting towards electromobility. Therefore it is necessary to also gain better knowledge about the environmental impacts of this technology. This includes a modelling of the pathways of the necessary increase in electricity supply and an appropriate modelling of battery manufacture. Summary of data presented At this forum most recent results of life cycle assessment studies of electric car driving compared to driving fossil- and agro-fuelled cars were presented. The environmental performance of indivi...

British Library Electronic Table of Contents (United Kingdom)

Air toxics from the industrial wastewater treatment plants (IWTPs) impose serious health concerns on its surrounding residential neighborhoods. To address such health concerns, one of the key challenges is to quantify the air emissions from the IWTPs. The objective here is to characterize the air emissions from the IWTPs and quantify its associated uncertainty. An IWTP receiving the wastewaters from an airplane maintenance facility is used for illustration with focus on the quantification of air emissions for benzyl alcohol, phenol, methylene chloride, 2-butanone, and acetone. Two general fate models, i.e., WATER9 and TOXCHEM+V3.0 were used to model the IWTP and quantify the air emissions. Monte Carlo and Bootstrap simulation were used for uncertainty analysis. On average, air emissions fr...

CERN Document Server

Motional heating of ions in micro-fabricated traps is a challenge hindering experimental realization of large-scale quantum processing devices. Recently a series of measurements of the heating rates in surface-electrode ion traps characterized their frequency, distance, and temperature dependencies, but our understanding of the microscopic origin of this noise is still vague. In this work we develop a theoretical model for the electric field noise which is associated with a random distribution of adsorbed atoms on the trap electrode surface. By using first principle calculations of the fluctuating dipole moments of the adsorbed atoms we evaluate the distance, frequency and temperature dependence of the resulting electric field fluctuation spectrum.Our theory calculates the noise spectrum beyond the standard scenario of two-level fluctuators, by incorporating all the relevant vibrational states. The $1/f$ noise is shown to commence at roughly ...

Science.gov (United States)

We describe an efficient procedure for proving stabilization of biological systems modeled as qualitative networks or genetic regulatory networks. For scalability, our procedure uses modular proof techniques, where state-space exploration is applied only locally to small pieces of the system rather than the entire system as a whole. Our procedure exploits the observation that, in practice, the form of modular proofs can be restricted to a very limited set. For completeness, our technique falls back on a non-compositional counterexample search. Using our new procedure, we have solved a number of challenging published examples, including: a 3-D model of the mammalian epidermis; a model of metabolic networks operating in type-2 diabetes; a model of fate determination of vulval precursor cells in the C. elegans worm; and a model of pair-rule regulation during ...

Energy Technology Data Exchange (ETDEWEB)

Pacific Northwest National Laboratory and a group of expert collaborators are using the U.S. Department of Energy Hanford Site 300 Area uranium plume within the footprint of the 300-FF-5 groundwater operable unit as a site for an Integrated Field-Scale Subsurface Research Challenge (IFRC). The IFRC is entitled Multi-Scale Mass Transfer Processes Controlling Natural Attenuation and Engineered Remediation: An IFRC Focused on the Hanford Site 300 Area Uranium Plume Project. The theme is investigation of multi-scale mass transfer processes. A series of forefront science questions on mass transfer are posed for research that relate to the effect of spatial heterogeneities; the importance of scale; coupled interactions between biogeochemical, hydrologic, and mass transfer processes; and measurements/approaches needed to characterize and model a mass transfer-dominated system. This Quality Assurance Project Plan provides the quality assurance ...

British Library Electronic Table of Contents (United Kingdom)

Sepsis induced by methicillin-resistant Staphylococcus aureus (MRSA) has worse outcome because of multiresistance to a large group of antibiotics, which may lead to death from septic shock. In the present study, we firstly found that artesunate in combination with oxacillin was capable of protecting mice challenged with live MRSA WHO-2 (WHO-2) and the protection was related to the reduced TNF-a and IL-6 levels and decreased bacterial load. Based on above results, artesunate was further investigated from two aspects in vitro, anti-inflammation effect and antibacterial enhancement effect on antibiotics. Artesunate not only inhibited TNF-a and IL-6 release but also inhibited mRNA and protein expressions of TLR2 and Nod2, two important receptors, in murine peritoneal macrophages stimulated wit...

Energy Technology Data Exchange (ETDEWEB)

Combustion scientists are primarily concerned with the fuels most often burned as energy sources (coal, petroleum products, and natural gas), with the goal of learning to burn them as efficiently, intensely, and cleanly as possible. Discovering those slight rearrangements of chemical bonds that together account for the net chemical transformation is the key to understanding how combustion proceeds. Once these reactions have been defined, the chemist can determine the rate coefficient of each reaction as a function of temperature and assemble the information into flame models. The computer programs that use these models to predict experimental results combine two sets of equations describing (1) the diffusive and reactive rates of change in concentration of all the molecules in the flame and (2) the flow of the reacting gases. Although the details of hydrocarbon-flame models are still disputed, many of their general features ...

Environmental Research Database

ObjectivesThe objective of this meeting will be to interface the two ends of the particulate flow spectrum - those working to understand the fundamentals of granular flows and those attempting to control particulate flows in an industrial setting - to develop solutions to the complex problems presented by dense granular flows. We will aim~%~~%~to provide a forum for the interface between practical users of particulate technology and the developers of theories for understanding granular flow;~%~to present [continued...]DescriptionIn practical situations such as those met in industry where segregation and mixing are important, understanding particulate flows is complex due to the presence of polydispersity, anisotropy and complex grain morphology. In attempting to model such systems, many of these features are generally ignored, except perhaps through empirical parameter fitting. Developing a theory to include these effects is a considerable ...

Energy Technology Data Exchange (ETDEWEB)

The indirect conversion of coal to liquid hydrocarbons via steam gasification followed by synthesis gas (CO/H/sub 2/) chemistry has been the subject of intensive study for a number of decades. A key technological challenge facing researchers in this area is control over the product distribution during the hydrocarbon synthesis step. In the case of iron Fischer-Tropsch catalysts, it has been known that the addition of alkali to the metal catalyst has a significant impact on the product distribution. Iron catalysts treated with alkali produce less methane more alkenes and higher molecular weight products. In spite of numerous investigations, the details of this promotional effect are not understood on a molecular level. To explore the role of alkali in the surface chemistry of iron catalysts, the authors have carried out a combined surface science and catalytic kinetic study of a model iron catalyst with and without surface alkali.

British Library Electronic Table of Contents (United Kingdom)

From its inception in 1977, the U.S. Department of Energy (DOE) has been responsible for maintaining the nations nuclear stockpile, leading the country in terms of basic research, setting national energy goals, and managing thousands of individual programs. Despite these gains, however, the DOE research and development (R&D) model does not appear to offer the nation an optimal strategy for assessing long-term energy challenges. American energy policy continues to face constraints related to three "Is": inconsistency, incrementalism, and inadequacy. An overly rigid management structure and loss of mission within the DOE continues to plague its programs and create inconsistencies in terms of a national energy policy. Various layers of stove-piping within and between the DOE and national labo...

Energy Technology Data Exchange (ETDEWEB)

Physicians are exercising their responsibility as healers in their efforts to prevent nuclear war. Death for Hiroshima survivors was experienced in four stages: the immediate impact of destruction, the acute impact of radiation, delayed radiation effects, and later identification as an atomic bomb survivor. Each phase had its physical and psychological impacts and negates Hiroshima as a model for rational behavior despite those who claim survival is possible for those who are prepared. The psychic effects of modern nuclear, chemical, and germ warfare need to be challenged with a symbolization of life and immortality. Studies of psychological reactions to the terror children felt during practice air-raid drills indicate that the fears can be surpressed and re-emerge in adult life as a linking of death with collective annihilation. Other themes which emerge are feelings of impermanence, craziness, identification with the bomb, and a double ...

Energy Technology Data Exchange (ETDEWEB)

We summarize recent developments in x-ray microscopy of polymers by focusing on the characterization of organic electronic devices. The quantitative compositions of model polymer blends have been mapped at a resolution of {approx}35 nm. Since it could be inferred that these devices have structures smaller than 35 nm, quantitative compositional mapping at length scales below the present resolution limit of x-ray microscopy is required. Organic devices thus serve to both highlight the success of NEXAFS microscopy to date, but to also outline the very real need for higher spatial resolution. New approaches to create improved optics or different acquisition modalities are required if x-ray microscopy is to make sustained contributions to such an important area of research as organic devices.

British Library Electronic Table of Contents (United Kingdom)

Purpose - The purpose of this paper is to interview Paula Kaufman, Dean of Libraries, to help better understand return on investment (ROI) and the increasing importance of demonstrating our value, as libraries, as librarians, indeed, as public service librarians. Design/methodology/approach - During 2007, a small project team was assembled to develop a model that would calculate a return on investment to an institution for its library. The team consisted of Chrysanne Lowe and Kira Cooper from Elsevier, Paula Kaufman from UIUC, Judy Luther of Informed Strategies, and Dr Carol Tenopir from the Center for Information and Communication Studies at the University of Tennessee, Knoxville. Findings - The results of this groundbreaking study were reported early this year in a white paper entitled, ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Gaseous microemboli (GME) remain a challenge for cardiopulmonary bypass (CPB) because there is a positive correlation between microemboli exposure during CPB and postoperative neurological injury. Thus, minimizing the number of GME delivered to pediatric patients undergoing CPB procedures would lead to better clinical outcomes. In this study, we used a simulated CPB model to evaluate the effectiveness of capturing GME and the degree of membrane pressure drop for a new membrane oxygenator, Capiox Baby FX05 (Terumo Corporation, Tokyo, Japan), which has an integrated arterial filter with open and closed purge line. We used identical components in this study as our clinical CPB circuit. Three emboli detection and classification quantifier transducers were placed at prepump, preoxygena...

British Library Electronic Table of Contents (United Kingdom)

ContextCost advantage has been one of the primary drivers of successful offshoring engagements of Indian software and services companies. However, the emphasis has shifted to the ability of the vendors to provide high quality over cost advantage in delivering software products and services. Meeting high quality requirements of the clients is a challenge due to the very nature of development and delivery of software through offshoring. ObjectiveThe objective of this research paper is to identify and evaluate the key determinants of quality in the case of software projects delivered through offshoring model. MethodA detailed survey was conducted among project managers/project leaders (leads) of a leading midsize Indian IT services company to evaluate the relationship of the determinants on t...

CERN Document Server

The lowest-mass stars, brown dwarfs and extrasolar planets present challenges and opportunities for understanding dynamics and cloud formation processes in low-temperature atmospheres. For brown dwarfs, the formation, variation and rapid depletion of photospheric clouds in L- and T-type dwarfs, and spectroscopic evidence for non-equilibrium chemistry associated with vertical mixing, all point to a fundamental role for dynamics in vertical abundance distributions and cloud/grain formation cycles. For exoplanets, azimuthal heat variations and the detection of stratospheric and exospheric layers indicate multi-layered, asymmetric atmospheres that may also be time-variable (particularly for systems with highly elliptical orbits). Dust and clouds may also play an important role in the thermal energy balance of exoplanets through albedo effects. For all of these cases, 3D atmosphere models are becoming an increasingly essential tool for understanding ...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Energy Technology Data Exchange (ETDEWEB)

The papers collected in this volume were presented at the 4th Colloquium on Process Simulation held at Helsinki University of Technology, Espoo, Finland, June 11-13, 1997. In the more developed industrial nations, the processes for producing chemicals, energy, and materials encounter environmental concern and laws which challenge engineers to develop the processes towards more efficient, economical and safe operation. This necessitates more thorough understanding of the processes and phenomena involved. Formerly, the development of the processes was largely based on trial and error, whereas today, the development of computer performance together with the diversification of modelling software enables simulation of the processes. The increased capacity and possibilities for modelling the processes brought by the improved hardware and software, have generated a strong demand for more accurate mathematical descriptions of the ...

Science.gov (United States)

A strategic partnership was formed among the American Foundrymen`s Society and the Federal government to develop and transfer the technology needed by the US foundry industry to: increase energy efficiency of cupola melting; improve recovery of carbon, silicon, and manganese through reduced oxidation losses; and improve productivity due to more uniform and predictable iron compositions. An effective mathematical model of the cupola offers a solution to the complex and interactive chemical and heat transfer processes to melt cast iron. The transient changes in charge size, charge composition, blast rate, and coke rate are used to optimize operation to improve melting rates, minimize oxidation losses of valuable alloying elements (C, Si, and Mn), and maintain iron composition. Despite these challenges, the cupola produces iron at a lower cost, and have better environmental controls than other melting process with 70% of domestic liquid iron ...

Energy Technology Data Exchange (ETDEWEB)

Because of the equivalence principle, a global measurement is necessary to distinguish gravity from acceleration of the reference frame. A gravity gradiometer is therefore an essential instrument needed for precision tests of gravity laws and for applications in gravity survey and inertial navigation. Superconductivity and SQUID (superconducting quantum interference device) technology can be used to obtain a gravity gradiometer with very high sensitivity and stability. A superconducting gravity gradiometer has been developed for a null test of the gravitational inverse-square law and space-borne geodesy. Here we present a complete theoretical model of this instrument. Starting from dynamical equations for the device, we derive transfer functions, a common mode rejection characteristic, and an error model of the superconducting instrument. Since a gradiometer must detect a very weak differential gravity signal in the midst of large platform ...

International Nuclear Information System (INIS)

Core-collapse supernovae are among Nature's most energetic events. They mark the end of massive star evolution and pollute the interstellar medium with the life-enabling ashes of thermonuclear burning. Despite their importance for the evolution of galaxies and life in the universe, the details of the core-collapse supernova explosion mechanism remain in the dark and pose a daunting computational challenge. We outline the multi-dimensional, multi-scale, and multi-physics nature of the core-collapse supernova problem and discuss computational strategies and requirements for its solution. Specifically, we highlight the axisymmetric (2D) radiation-MHD code VULCAN/2D and present results obtained from the first full-2D angle-dependent neutrino radiation-hydrodynamics simulations of the post-core-bounce supernova evolution. We then go on to discuss the new code Zelmani which is based on the open-source HPC Cactus framework and provides a scalable AMR approach for 3D fully ...

Energy Technology Data Exchange (ETDEWEB)

The goal of this DOE Vision-21 project work scope is to develop an integrated suite of software tools that can be used to simulate and visualize advanced plant concepts. Existing process simulation software does not meet the DOE's objective of ''virtual simulation'' which is needed to evaluate complex cycles. The overall intent of the DOE is to improve predictive tools for cycle analysis, and to improve the component models that are used in turn to simulate the cycle. Advanced component models are available; however, a generic coupling capability that will link the advanced component models to the cycle simulation software remains to be developed. In the current project, the coupling of the cycle analysis and cycle component simulation software will be based on an existing suite of programs. The challenge is to develop a general-purpose software and ...

UK PubMed Central (United Kingdom)

The challenge to our profession today is to improve the quality of oral health while overcoming both extrinsic and intrinsic factors which may adversely affect our progress toward this goal. The combined...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundFor hundred of years, people in the region encompassed by the Afghanistan-Iran-Pakistan borders (AIP region) have been challenged by conflict and political and civil instability,...Full Text Available

UK PubMed Central (United Kingdom)

PurposeIntestinal stomas can pose significant challenges for long-term (≥ 5 years) rectal cancer (RC) survivors. Specifying common challenges and sociodemographic or clinical...Full Text Available

Science.gov (United States)

This article is a case study of an Internet chat room outreach project in Perth, Western Australia. The CyberReach project sought to adapt current peer based health promotion outreach, training and supervision frameworks to an online outreach setting in a way that was effective and supported by the online community. It targeted marginalised groups to trial the provision of online mental and sexual health promotion incorporating a participatory action research model into its development and implementation. Three 6-week trial periods were conducted and significant changes were made in response to changes in the online environment and to improve sustainability and effectiveness of the protocols. Four themes arose from CyberReach's experience: online group processes are unique due to the creation of extensive personal networks and occurrence of disclosure without face-to-face contact across potentially large geographic barriers; flexibility is required to adapt to ...

Science.gov (United States)

PMID:16528188

Science.gov (United States)

digital libraries, which was identified as a national challenge in the Information ... The linkages between the many digital libraries and information services are ...

CERN Document Server

The subject of the 5th challenge proposed by the French Society of Operations Research and Decision Analysis (ROADEF) consists in scheduling technicians and interventions for telecommunications (http://www.g-scop.inpg.fr/ChallengeROADEF2007/ or http://www.roadef.org/). We detail the algorithm we proposed for this challenge which is a Greedy Randomized Adaptative Search Procedure (GRASP). Computational results led us to the 1st position in the Junior category and to the 4th position in All category of the Challenge ROADEF 2007.

Science.gov (United States)

Percutaneous osseointegrated prostheses are being investigated as an alternative strategy to attach prosthetic limbs to patients. Although the use of these implants has shown to be promising in clinical trials, the ability to maintain a skin seal around an osseointegrated implant interface is a major challenge to prevent superficial and deep periprosthetic infections. The specific aim of this study was to establish a translational load-bearing ovine model to assess postoperative limb compensation and gait symmetry following a percutaneous osseointegrated implant. We tested the following hypotheses: (1) the animals would return to pre-amputation limb loads within 12-months; (2) the animals would return to a symmetrical gait pattern (stride length and time in stance) within 12-months. The results demonstrated that one month following surgery, the sheep loaded their amputated limb to a mean value of nearly 80% of their pre-amputation loading ...

Energy Technology Data Exchange (ETDEWEB)

The UK government's economy-wide 60% carbon dioxide reduction target by 2050 requires a paradigm shift in the whole energy system. Numerous analytical studies have concluded that the power sector is a critical contributor to a low carbon energy system, and electricity generation has dominated the policy discussion on UK decarbonisation scenarios. However, range of technical, social and market challenges, combined with alternate market investment strategies mean that large scale deployment of key classes of low carbon electricity technologies is fraught with uncertainty. The UK MARKAL energy systems model has been used to investigate these long-term uncertainties in key electricity generation options. A range of power sector specific parametric sensitivities have been performed under a 'what-if' framework to provide a systematic exploration of least-cost energy system configurations under a broad, integrated set of ...

Energy Technology Data Exchange (ETDEWEB)

The LANL Environmental Restoration (ER) Program Office, established in October 1989, is faced with the challenge of assessing and cleaning up nearly 1,8000 potentially hazardous waste sites according to an aggressive corrective action schedule that the Environmental Protection Agency (EPA) mandated on May 23, 1990, in a Resource, Conservation, and Recovery Act (RCRA) Part B Permit. To maximize program efficiency, the ER Program Office will implement a unique management approach designed to maximize the use of laboratory technical expertise. The Installation Work Plan, which provides a blueprint for the program, has been submitted to EPA for review and approval. A work plan for characterization of Technical Area 21, an early plutonium processing facility, is also nearing completion. The feasibility of an expedited cleanup of the Laboratory's worst hazardous waste release has been modelled using a computer code originally developed by ...

Science.gov (United States)

The Simplified Boiling Water Reactor (SBWR) designed by General Electric is a natural circulation reactor with enhanced safety features for potential accidents. It has a strong coupling between power and flow in the reactor core, hence the neutronic coupling with thermal-hydraulics is specially important. The potential geysering instability during the early part of a SBWR startup at low flow, low power and low pressure is of particular concern. The RAMONA-4B computer code developed at Brookhaven National Laboratory (BNL) for the SBWR has been used to simulate a SBWR startup transient and evaluate its stability, using a simplified four-channel representation of the reactor core for the thermal-hydraulics. This transient was run for 20,000 sec (5.56 hrs) in order to cover the essential aspect of the SBWR startup. The simulation showed that the SBWR startup was a very challenging event to analyze as it required accurate modeling of the ...

Energy Technology Data Exchange (ETDEWEB)

At the 1996 Conference in North Carolina, The Green Institute began to share its story. Their presentation this year will cover where they are in the design process and their plans for using solar and wind technologies in the development of an Eco-Industrial Park and Business Incubator. Located in a Federal Enterprise Community in Minneapolis, this project borrows sustainable and green building principles using the Rocky Mountain Institute and Solar Living Center as models. Using a change in the paradigm regarding how industry does business, The Green Institute is joining with developments across the country that are putting together Eco-Industrial Parks which use closed loop production systems to reduce waste and emissions generated from manufacturing processes. Using renewable energy, both solar and wind, presents challenges both in the integration of systems on this small site and the educational opportunities with a large potential audience ...

Science.gov (United States)

The usefulness of psychoanalysis to psychosomatic medicine has been limited by the longstanding assumption that the psychological disorder in psychosomatic patients resembles the conflict-based psychopathology that Freud identified in psychoneurotic patients. Recent investigations of the alexithymia construct, and the discovery that social relationships can influence health over the entire life span, have challenged this assumption and created an opportunity for a new and active involvement of psychoanalysis with psychosomatic medicine. In this contribution, I offer a synthesis of contemporary psychoanalytic observations and theories with concepts and research findings from developmental psychology, developmental biology, and the biomedical sciences. The proposed synthesis is consistent with the view that living organisms are self-regulating cybernetic systems; it also extends an evolving new psychosomatic model that conceptualizes illnesses ...

DEFF Research Database (Denmark)

It is well established from experiments in premixed, laminar flames, jet-stirred reactors, flow reactors, and batch reactors that SO2 acts to catalyze hydrogen atom removal at stoichiometric and reducing conditions. However, the commonly accepted mechanism for radical removal, SO2 + H(+M) reversible arrow HOSO(+M), HOSO + H/OH reversible arrow SO2 + H-2/H2O, has been challenged by recent theoretical and experimental results. Based on ab initio calculations for key reactions, we update the kinetic model for this chemistry and re-examine the mechanism of fuel/SO2 interactions. We find that the interaction of SO, with the radical pool is more complex than previously assumed, involving HOSO and SO, as well as, at high temperatures also HSO, SH, and S. The revised mechanism with a high rate constant for H + SO2 recombination and with SO + H2O, rather than SO2 + H-2, as major products of the HOSO + H reaction is in agreement with a range of ...

International Nuclear Information System (INIS)

Detection of fatigue damage cracks in aircraft skin structures is an ongoing NDT challenge. Cracks growing rate is difficult to predict, and for this reason, it is important to detect them as soon as possible to avoid a catastrophic break. Eddy current methods are known and well-accepted techniques which are relatively simple to carry out. However, with conventional inspection of airframe structures using standard driver-pickup eddy current probes, it is difficult to detect small fatigue cracks initiated in the second layer of the skin and in the shadow region at fastener holes. Such difficulty is related to fasteners length and their spacing which reduces test sensitivity. This report explains the development of improved eddy current probe/technique to detect and visualize fatigue cracks in fasteners. In this study, an eddy current array probe was evaluated and new coil design was suggested. Several tests were conducted on an A-300 circumferential joint sample ...

CERN Document Server

Data mining is a useful decision support technique that can be used to discover production rules in warehouses or corporate data. Data mining research has made much effort to apply various mining algorithms efficiently on large databases. However, a serious problem in their practical application is the long processing time of such algorithms. Nowadays, one of the key challenges is to integrate data mining methods within the framework of traditional database systems. Indeed, such implementations can take advantage of the efficiency provided by SQL engines. In this paper, we propose an integrating approach for decision trees within a classical database system. In other words, we try to discover knowledge from relational databases, in the form of production rules, via a procedure embedding SQL queries. The obtained decision tree is defined by successive, related relational views. Each view corresponds to a given population in the underlying decision tree. We selected ...

Energy Technology Data Exchange (ETDEWEB)

Aerodynamics play a critical role in the success of a competitive solar vehicle. In particular, the topics addressed in this paper are minimizing the drag forces acting on the car surface while providing an effective angle of solar exposure, ventilation, manoeuvring stability, maintenance accessibility, and component `functional duality`, while simultaneously maintaining stringent racing regulations. Starting with a conceptual design, modifications were analysed through a commercial, computational fluid dynamics (CFD) package in order to evaluate drag and lift characteristics. By visualizing wind tunnel flow as a means of support of the coded model, the computational design has been validated. Although the design of the George Washington University (GWU) solar car `Sunforce 1` was geared towards the November 1993 World Solar Challenge held in Australia, results of the fourth place finish in the US Sunrace `93 were used to demonstrate the ...

Wastenet

...Polymer Fuel Cells Challenge Publications News Events Login Register Search Content type All Web pages Case studies Publications News Video Home ...Buildings Carbon capture & storage Combined heat & power Electricity transmission & distribution Energy storage Fuel cells Geothermal Hydroelectric Hydrogen Industry Lighting Marine Metering Nuclear Solar Transport Wind ...Home Emerging technologies Current focus areas Polymer Fuel Cell Challenge Polymer Fuel Cells Challenge The objective of the Polymer Fuel Cells Challenge is to develop,...prove and commercialise novel polymer fuel cell technologies that have the potential to deliver a step-change in overall system cost. What are ...

Science.gov (United States)

This thesis study covers both global performance and local phenomena analyses focusing on natural circulation reactor design safety. Four important topics are included: the global SBWR design safety assessment, important local phenomena investigation, steady and transient natural circulation process study, and two-phase instability analysis. The conceptual design of the SBWR-200 is introduced in this thesis and the global performance of a natural circulation reactor is then assessed using PUMA integral test data and RELAP5 simulations. A safety assessment methodology is developed to evaluate the PUMA integral test data extrapolation and code scalability. The RELAP5 code simulation capability in low-pressure low-flow conditions is also validated. The study shows that the code is capable of predicting the global accident scenario in natural circulation reactors with reasonable accuracy, while failing to reproduce some safety related local phenomena. The natural circulation process is ...

Energy Technology Data Exchange (ETDEWEB)

The development of rechargeable lithium batteries with a high mass capacity, made with non-toxic and low cost materials is an important industrial challenge. Morphological and structural modifications occurring in the electrode materials during charge-output cycles should not lower the electrochemical characteristics and the cycling properties of the battery. Thus the structure of electrode materials must be sufficiently deformable and stable to support the constraints linked with lithium intercalation and de-intercalation (ions and electrons absorption/extraction). The aim of this work is to explain some characteristics (mass capacity, ions and electrons mobility, cycling) using the relation between some mechanisms of lithium insertion (sites occupation, lattice reduction mods) and the nature of atoms and chemical bonds (covalence, ionicity). This approach is developed on 2-D models of crystallized and vitreous sulfur compounds (CdI{sub 2} ...

Science.gov (United States)

David N. Spires and Rick W. Sturdevant, "From Advent to Milstar: The United States Air Force and the Challenges of Military Satellite Communications. Chapter 8 ...

Science.gov (United States)

Challenges of robotic cars, sponsored by the Defense Advanced Research Projects Agency (DARPA) of the U.S. Defense Department. Carroll Cordes, recently retired USGS branch chief,...

UK PubMed Central (United Kingdom)

The currently available methods for the diagnosis of dry eye are still far from being perfect for a variety of reasons. This review attempts to highlight the advantages and disadvantages of both traditional...Full Text Available

UK PubMed Central (United Kingdom)

With advances in treatment, colorectal cancer is being transformed from a deadly disease to an illness that is increasingly curable. With this transformation has come increased interest in the...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Short communication

Energy Technology Data Exchange (ETDEWEB)

This paper first discusses the challenge offered by natural and anthropogenic systems in all of their complexity and then indicates some areas of research in which specific scientific and technological needs are identifiable.

Science.gov (United States)

... 124 Headquarters, 82nd Airborne Division, 82nd Airborne Division Airborne Standing Operating Procedures ... the Light Infantry divisions during the ...

UK PubMed Central (United Kingdom)

Background. The coexistence of neoplasm and abdominal aortic aneurysm (AAA) presents a real management challenge. This paper reviews the literature on the prevalence, diagnosis,...Full Text Available

Science.gov (United States)

Dec 9, 2005 ... Classification of high resolution imagery is not as straightforward as more ... The challenges of classifying high resolution imagery stems ...

UK PubMed Central (United Kingdom)

Motivation: Inference of haplotypes from genotype data is crucial and challenging for many vitally important studies. The first, and most critical step, is the ascertainment of a biologically...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This presentation details how wind turbine gearboxes fail to meet 20-year design life and how the Gearbox Reliability Collaborative (GRC) is addressing the challenges.

UK PubMed Central (United Kingdom)

The pleiotropic actions of neuromodulators on pre- and postsynaptic targets present challenges to disentangling the mechanisms underlying regulation of synaptic transmission. Within the striatum,...Full Text Available

Science.gov (United States)

... times, in Iran (Persia), the Arabian Gulf region, East Africa, territories of the former Ottoman Empire, parts of Eastern Europe ...

Energy Technology Data Exchange (ETDEWEB)

The paper reviews the US Clean Coal Technology program, discussing some of the projects, before describing the Vision 21 program.

UK PubMed Central (United Kingdom)

Adaptive radiation therapy for liver cancer has the potential to reduce normal tissue complications and enable dose escalation, allowing the potential for tumor control in this challenging site....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The current specifications of the LLNL fusion-fission hybrid proposal, namely LIFE, impose severe constraints on materials, and in particular on the nuclear fissile or fertile nuclear fuel and its immediate environment. This constitutes the focus of the present report with special emphasis on phase formation and phase transformations of the transmutation fuel and their consequences on particle and pebble thermal, chemical, and mechanical integrities. We first review the work that has been done in recent years to improve materials properties under the Gen-IV project, and with in particular applications to HTGR and MSR, and also under GNEP and AFCI in the USA. Our goal is to assess the nuclear fuel options that currently exist together with their issues. Among the options, it is worth mentioning TRISO, IMF, and molten salts. The later option will not be discussed in details since an entire report (Volume 8 - Molten-salt Fuels) is dedicated to it. Then, in a second part, with the specific ...

Science.gov (United States)

The advancement of bioprocess monitoring will play a crucial role to meet the future requirements of bioprocess technology. Major issues are the acceleration of process development to reduce the time to the market and to ensure optimal exploitation of the cell factory and further to cope with the requirements of the Process Analytical Technology initiative. Due to the enormous complexity of cellular systems and lack of appropriate sensor systems microbial production processes are still poorly understood. This holds generally true for the most microbial production processes, in particular for the recombinant protein production due to strong interaction between recombinant gene expression and host cell metabolism. Therefore, it is necessary to scrutinise the role of the different cellular compartments in the biosynthesis process in order to develop comprehensive process monitoring concepts by involving the most significant process variables and their interconnections. Although research ...

Energy Technology Data Exchange (ETDEWEB)

Ulrich in the forward to the Zenger and Folkman (2002) book, ''The Extraordinary Leader'', wrote about the importance of character in leadership stating, ''Everything about great leaders radiates from character. Character improves the probability of exhibiting strong interpersonal skill. Some of this perceived character is innate . . . but more is driven by the leader's self-awareness and interactions with others'' (p. ix). The purpose of this study was to explore the relationship between leadership effectiveness and character using leader-managers of knowledge workers as the subject sample. Findings indicated that character, particularly those factors associated with honesty, setting the example, and valuing and strengthening others, were what set the most effective leader-managers apart from their peers. Technical competence and self-efficacy were found to be common characteristics of the study sample as ...

Energy Technology Data Exchange (ETDEWEB)

Description is given of how the design challenges were met in commissioning the Sasol Two plant in 1980, a larger plant than Sasol One, and devoted to producing liquid fuels. The design parameters included treating South African coals of poor quality with high ash contents, and rapidity in building the plant.

Environmental Research Database

ObjectivesObjectives Not AvailableDescriptionOne significant research challenge posed by the growing number of older people in the population concerns the mobility-related problems which increase with age, inhibit independence, and can be a prime cause of admission to expensive institutional settings. The scope for engineering advances, particularly in the field of rehabilitation and assistive technology, is immense. The challenge is to produce aids, devices and products that are attractive to older people themselves, since without such [continued...

UK PubMed Central (United Kingdom)

BackgroundThe effects of single or combined histamine H₁-receptor and leukotriene CysLT₁-receptor antagonism on nasal adenosine monophosphate (AMP) challenge...Full Text Available

International Nuclear Information System (INIS)

The proceedings include the following lectures: Facing the challenges - new structures for electricity production. Renewable energies in Europe - chances and challenges. Nuclear outlook in the UK. Sustainable energy for Europe. Requirements of the market and the grid operator at the electricity production companies. Perspectives for the future energy production. Pumped storage plants - status and perspectives. Nuclear power/renewable energies -partners or opponents? New fossil fired power stations in Europe - status and perspectives. Nuclear energy: outlook for new build and lifetime extension in Europe. Biomass in the future European energy market - experiences for dong energy. Meeting the EU 20:20 renewable energy targets: the offshore challenges. DESERTEC: sustainable electricity for Europe, Middle East and North Africa. New power plants in Europe - a challenge for project and quality management. ...

Science.gov (United States)

BackgroundBiodiesel or ethanol derived from lipids or starch produced by microalgae may overcome many of the sustainability challenges previously ascribed to petroleum-based fuels and first generation plant-based biofuels. The paucity of microalgae genome sequences, however, limits gene-based biofuel feedstock optimization studies. Here we describe the sequencing and de novo transcriptome assembly for the non-model microalgae species, Dunaliella tertiolecta, and identify pathways and genes of importance related to biofuel production.ResultsNext generation DNA pyrosequencing technology applied to D. tertiolecta transcripts produced 1,363,336 high quality reads with an average length of 400 bases. Following quality and size trimming, ~ 45% of the high quality reads were assembled into 33,307 isotigs with a 31-fold coverage and 376,482 singletons. Assembled sequences and singletons were subjected to BLAST similarity searches and annotated with ...

International Nuclear Information System (INIS)

Single-crystalline nanostructures often exhibit gradients of surface (and/or interface) curvature that emerge from fabrication and growth processes or from thermal fluctuations. Thus, the system-inherent capillary force can initiate morphological transformations during further processing steps or during operation at elevated temperature. Therefore and because of the ongoing miniaturization of functional structures which causes a general rise in surface-to-volume ratios, solid-state capillary phenomena will become increasingly important: On the one hand diffusion-mediated capillary processes can be of practical use in view of non-conventional nanostructure fabrication methods based on self-organization mechanisms, on the other hand they can destroy the integrity of nanostructures which can go along with the failure of functionality. Additionally, capillarity-induced shape transformations are effected and can thereby be controlled by applied fields and forces (guided or driven ...

Energy Technology Data Exchange (ETDEWEB)

By contrast to the large mass, complexity and recirculating power of conventional drivers for inertial confinement fusion (ICF), antiproton annihilation offers a specific energy of 90MJ/{micro}g and thus a unique form of energy packaging and delivery. In principle, antiproton drivers could provide a profound reduction in system mass for advanced space propulsion by ICF. We examine the physics underlying the use of antiprotons ({bar p}) to drive various classes of high-yield ICF targets by the methods of volumetric ignition, hotspot ignition and fast ignition. The useable fraction of annihilation deposition energy is determined for both {bar p}-driven ablative compression and {bar p}-driven fast ignition, in association with 0-D and 1-D target burn models. Thereby, we deduce scaling laws for the number of injected antiprotons required per capsule, together with timing and focal spot requirements. The kinetic energy of the injected antiproton beam required to ...

Energy Technology Data Exchange (ETDEWEB)

The measurement of q{sub o} is extremely important for understanding the quantity of matter in our universe. The measurement of q{sub o} using supernovae of type Ia as standard candles is appealing because it requires less modeling than other methods using galaxies. The challenge with using supernovae to measure q{sub o} is in finding enough of them. In order to find supernovas, we have constructed a very popular f/1 camera for the 3.9m Anglo-Australian Telescope. The camera uses reducing optics that put a 17 in. {times} 17 in. field on a 1024 {times} 1024 pixel Thomson CCD. Using this system, we image to 23rd magnitude in five minutes. We have developed a software package that uses image subtraction to find supernovae that are approximately magnitude 22.4 or brighter in these images. One field can be processed every 6.6 minutes on a relatively unloaded VAX 6000-6510. We estimate that this system should find one supernova in every 105--139 ...

Energy Technology Data Exchange (ETDEWEB)

General-Purpose Heat Source radioisotope thermoelectric generators (GPHS-RTGs) will provide electrical power for the NASA Galileo and European Space Agency (ESA) Ulysses missions. Each GPHS-RTG comprises two major components: GPHS modules, which provide thermal energy, and a thermoelectric converter, which converts the thermal energy into electrical power. Each of the 18 GPHS modules in a GPHS-RTG contains four /sup 238/PuO/sub 2/-fueled capsules. LANL conducted a series of safety verification tests on the GPHS-RTG before the scheduled May 1986 launch of the Galileo spacecraft to assess the ability of the GPHS modules to contain plutonia in potential accident environments. As a result of the Challenger 51-L accident in January 1986, NASA postponed the launch of Galileo; the spacecraft launch vehicle was reconfigured and the spacecraft trajectory modified. These actions prompted NASA to reevaluate potential mission accidents and the extended series safety test ...

Science.gov (United States)

In 2009 the European Space Agency satellite mission GOCE (Gravity Field and Steady-State Ocean Circulation Explorer) was launched. Its objectives are the precise and detailed determination of the Earth's gravity field and geoid. Its core instrument, a three axis gravitational gradiometer, measures the gravity gradient components V xx , V yy , V zz and V xz (second-order derivatives of the gravity potential V) with high precision and V xy , V yz with low precision, all in the instrument reference frame. The long wavelength gravity field is recovered from the orbit, measured by GPS (Global Positioning System). Characteristic elements of the mission are precise star tracking, a Sun-synchronous and very low (260 km) orbit, angular control by magnetic torquing and an extremely stiff and thermally stable instrument environment. GOCE is complementary to GRACE (Gravity Recovery and Climate Experiment), another satellite gravity mission, launched in 2002. While GRACE is designed to ...

International Nuclear Information System (INIS)

Construction and commissioning period of NPP are reduced world over drastically by stringent schedule for financial and economic reasons. For meeting the schedule, commissioning of components and systems are started immediate after installation, while construction activities are continued in parallel at the same place. Parallel activities' and 'Time Constraint' have brought new challenges to 'Management of Fire and Industrial Safely' during commissioning. An innovative approach was used during such phase of commissioning of TAPP-3 and 4. This paper outlines challenges encountered during this phase and special approach and measures used to meet those challenges. This paper also outlines problems encountered during implementation of these measures and subsequent change in approach to ensure smooth and safe execution of activities. Primarily, challenges were conflicting requirements by various agencies to ...

British Library Electronic Table of Contents (United Kingdom)

The recent advances in RFID offer vast opportunities for research, development and innovation in agriculture. The aim of this paper is to give readers a comprehensive view of current applications and new possibilities, but also explain the limitations and challenges of this technology. RFID has been used for years in animal identification and tracking, being a common practice in many farms. Also it has been used in the food chain for traceability control. The implementation of sensors in tags, make possible to monitor the cold chain of perishable food products and the development of new applications in fields like environmental monitoring, irrigation, specialty crops and farm machinery. However, it is not all advantages. There are also challenges and limitations that should be faced in the...

Energy Technology Data Exchange (ETDEWEB)

Many organizations are challenged with the tasks of identifying customer needs and expectations for their products, anticipating future product needs, communicating a future product vision to clients, and designing with today's technology to bring a future vision to successful realization. The design evolution of plant control centres is one aspect of CANDU development that faces such challenges. The Disney Corporation is an example of an organization that has been successful in consistently meeting these challenges for over fifty years; and some of the design practices proven in moviemaking, theme park and resort layout, and vacation experience organization may be helpful and effective when applied in other domains. This paper summarizes the findings from an examination of Disney Corporation design practices, and suggests how some practices could be used to simplify and enhance the design of future CANDU control ...

Energy Technology Data Exchange (ETDEWEB)

An apparatus for measuring the overall decontamination factors of first and second filters located in a plenum. The first filter separates the plenum's upstream and intermediate chambers. The second filter separates the plenum's intermediate and downstream chambers. The apparatus comprises an aerosol generator that generates a challenge aerosol. An upstream collector collects unfiltered aerosol which is piped to first and second dilution stages and then to a laser aerosol spectrometer. An intermediate collector collects challenge aerosol that penetrates the first filter. The filtered aerosol is piped to the first dilution stage, diluted, and then piped to the laser aerosol spectrometer which detects single particles. A downstream collector collects challenge aerosol that penetrates both filters. The twice-filtered aerosol is piped to the aerosol spectrometer. A pump and several valves control the movement ...

UK PubMed Central (United Kingdom)

For an enzyme functioning predominantly in a seemingly housekeeping role of 5′ tRNA maturation, RNase P displays a remarkable diversity in subunit make-up across the three domains of...Full Text Available

Science.gov (United States)

Examines the effects of computer-based manufacturing technologies on employment opportunities and job skills. Describes the establishment of the Industrial Technology Institute in Michigan to develop and utilize advanced manufacturing technologies, and the institute's relationship to the state's community colleges. Reviews lessons learned from interinstitutional cooperation. Highlights future challenges. (DMM)

Science.gov (United States)

In this activity, students create two- and three-dimensional maps by using a data grid of an imaginary section of Earth's surface. They are challenged to create six different maps of various surface features and answer questions about them.

UK PubMed Central (United Kingdom)

Leakage after oesophageal anastomosis or perforation remains a challenge for the surgeon. Traditional management has been operative repair or intensive conservative management. Both treatments are...Full Text Available

UK PubMed Central (United Kingdom)

SummaryAgeing is a complex, challenging phenomenon that will require multiple, interdisciplinary approaches to unravel its puzzles. To assist basic research on ageing, we developed...Full Text Available

Science.gov (United States)

Clarifies the concept of universal basic education. Highlights the need for performance criteria and ways to measure literacy attainment. Identifies issues related to improving primary education, seeing adult literacy as its necessary complement. Underscores the substantial resources required to achieve universal basic education. (CH)

UK PubMed Central (United Kingdom)

BackgroundWith a growing number of genetic tests becoming available to the health and consumer markets, genetic health care providers in Canada are faced with the challenge of developing...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe variety of ways in which faces are categorized makes face recognition challenging for both synthetic and biological vision systems. Here we focus on two face processing...Full Text Available

Science.gov (United States)

Barbara), Arto Nurmikko (Brown U), Ed Petrow (DOE), Jim Brodrick (DOE), John Carrano (DARPA), Bob Karlicek (Gelcore), John Zolper (DARPA), and Steve Johnson (LBNL). This project...

UK PubMed Central (United Kingdom)

China’s methadone maintenance treatment program was initiated in 2004 as a small pilot project in just eight sites. It has since expanded into a nationwide program encompassing more than 680...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The background for the project of a solar-powered aircraft, designed and built by Dr. Paul McCready of California, is reported with details on the aircraft design and its flight across the English Channel.

UK PubMed Central (United Kingdom)

BackgroundAirway complications are among the most challenging problems after lung transplantation, and Self-Expandable Metallic Stents (SEMS) are used to treat airway complications...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Science and technology could be revolutionized by quantum computers, but building them from solid-state devices will not be easy. Robert W Keyes of IBM's research division outlines the challenges in scaling up the technology from lab experiments to practical devices. (U.K.)

UK PubMed Central (United Kingdom)

Background and objectives: Management of incidental renal artery and kidney abnormalities in patients undergoing computed tomography scans is a clinical challenge because their frequency in healthy...Full Text Available

UK PubMed Central (United Kingdom)

While most cancer survivors are at risk for being lost in the transition from treatment to survivorship, rural breast cancer survivors face special challenges that might place them at particular...Full Text Available

UK PubMed Central (United Kingdom)

Chest compression-only (CC-only) is now incorporated in the Norwegian protocol for dispatch guided CPR (cardiopulmonary resuscitation) in cardiac arrest of presumed cardiac aetiology.We present...Full Text Available

UK PubMed Central (United Kingdom)

Membrane protein structural biology is still a largely unconquered area, given that approximately 25% of all proteins are membrane proteins and yet less than 150 unique structures are available. Membrane...Full Text Available

UK PubMed Central (United Kingdom)

Hospitals as research environments are crucial in advancing evidence-based practice and translational research. The authors discuss issues related to hospital-based nursing research such as...Full Text Available

UK PubMed Central (United Kingdom)

Motivation: The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify...Full Text Available

UK PubMed Central (United Kingdom)

Conducting rigorous psychosocial intervention research with cancer patients has many challenges including encouraging them to join studies, asking them to engage in interventions or be part...Full Text Available

UK PubMed Central (United Kingdom)

Although management of warfarin is challenging for patients with chronic kidney disease (CKD), no prospective studies have compared response to warfarin among patients with minimal, moderate, and severe...Full Text Available

UK PubMed Central (United Kingdom)

The structural properties of brain extracellular space (ECS) are summarised by the tortuosity (λ) and the volume fraction (α). To determine if these two parameters were independent,...Full Text Available

UK PubMed Central (United Kingdom)

Immunotherapy has shown promise in a number of tumor types, but its exact role in sarcoma remains to be defined. Advanced bone and soft tissue sarcomas are challenging diseases to treat with an unmet...Full Text Available

UK PubMed Central (United Kingdom)

The concept of "one-stop information shopping" is becoming a reality at Columbia-Presbyterian Medical Center. Our goal is to provide access from a single workstation to clinical, research, and library...Full Text Available

UK PubMed Central (United Kingdom)

Alternative energy resources such as hydrogen and methane gases are becoming increasingly important for the future economy. A major challenge for using hydrogen is to develop suitable materials to store...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVETo estimate the relationship between the rate of gestational weight gain before the 50-g, 1-hour oral glucose challenge test screening for gestational diabetes...Full Text Available

UK PubMed Central (United Kingdom)

We used the idea of hierarchical control to study multi-muscle synergies during a whole-body sway task performed by a standing person. Within this view, at the lower level of the hierarchy,...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The paper evaluates exploration technology. Topics discussed are: Visions; the subsurface challenge; the creative tension; the exploration process; seismic; geology; organic geochemistry; seismic resolution; integration; drilling; value creation. 4 refs., 22 figs.

UK PubMed Central (United Kingdom)

Quality research, requiring large numbers of participants, in the intensive care unit (ICU) population requires multicentre collaboration. Although logistically challenging, this methodology reduces...Full Text Available

UK PubMed Central (United Kingdom)

Zebrafish transgenesis is a powerful and increasingly common strategy to assay vertebrate transcriptional regulatory control. Several challenges remain, however, to the broader application of...Full Text Available

UK PubMed Central (United Kingdom)

Molecular life science is one of the fastest-growing fields of scientific and technical innovation, and biotechnology has profound effects on many aspects of daily life—often with deep, ethical...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundGene duplication is the primary force of new gene evolution. Deciphering whether a pair of duplicated genes has evolved divergent functions is often challenging. The zebrafish...Full Text Available

UK PubMed Central (United Kingdom)

The prevalent surge in childhood and adolescent obesity within the past 3 decades poses a significant challenge for many pediatric clinicians who are charged with treating this condition. The...Full Text Available

UK PubMed Central (United Kingdom)

Pancreatic cysts are challenging lesions to diagnose and to treat. Determining which of the five most common diagnoses—pancreatic pseudocyst, serous cystic neoplasm (SCN), solid pseudopapillary...Full Text Available

UK PubMed Central (United Kingdom)

Cystic neoplasms of the pancreas are increasingly recognized due to the expanding use and improved sensitivity of cross-sectional abdominal imaging. Major advances in the last decade have led to an...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundLoss to follow-up (LTF) challenges the reporting of antiretroviral treatment (ART) programmes, since it encompasses patients alive but lost to programme and deaths misclassified...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Car-producers compete in launching hybrids and electric cars, but this does not mean the end for the good old combustion engine.The challenge is the introduction of more complexed costs and weight in the new technology. (AG)

Energy Technology Data Exchange (ETDEWEB)

The objectives for the financial sector with regard to climate change investments are to regard to sustainability policies, not just for itself, but also for borrowers and investment portfolios, and to assist in developing frameworks and products that will enable shareholders and clients to invest in commercial solutions to mitigate the impacts of climate change.

UK PubMed Central (United Kingdom)

Hepatocellular carcinoma (HCC) is one of the most critical global health issues. With frequent association of viral liver disease, HCC is highly complex, harboring both cancer and chronic liver disease....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Bluestein's Fast Fourier Transform (FFT), commonly called the Chirp-Z Transform (CZT), is a little-known algorithm that offers engineers a high-resolution FFT combined with the ability to specify bandwidth. In the field of digital signal processing, engineers are always challenged to detect tones, frequencies, signatures, or some telltale sign that signifies a condition that must be indicated, ignored, or controlled. One of these challenges is to detect specific frequencies, for instance when looking for tones from telephones or detecting 60-Hz noise on power lines. The Goertzel algorithm described in Embedded Systems Programming, September 2002, offered a powerful tool toward finding specific frequencies faster than the FFT.Another challenge involves analyzing a range of frequencies, such as recording frequency response measurements, matching voice patterns, or displaying spectrum information on the face of an ...

International Nuclear Information System (INIS)

Radionuclide bone metastases therapy is a major achievement of nuclear medicine. Development of less radiotoxic and more effective radiopharmaceuticals is therefore a challenge for radiopharmacists and industry. This paper reviews the application of rhenium-188 HEDP as a reactor- or generator-produced nuclide for bone metastases therapy. (author)

UK PubMed Central (United Kingdom)

New developments in the field of thoracic oncology have challenged the way pathologists approach the diagnosis of pulmonary carcinoma. Nonsmall cell carcinoma is no longer an adequate diagnostic category....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundStable transgenesis is an undeniable key to understanding any genetic system. Retrovirus-based insertional strategies, which feature several technical challenges when they...Full Text Available

UK PubMed Central (United Kingdom)

ObjectiveMaintaining weight loss is a major challenge in obesity treatment. Individuals often indicate that waning motivation prompts cessation of effective weight...Full Text Available

UK PubMed Central (United Kingdom)

Developing in vitro engineered hepatic tissues that exhibit stable phenotype is a major challenge in the field of hepatic tissue engineering. However, the rapid dedifferentiation of...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Developing a modern electric power sector is necessary for economic growth and development to proceed. Institutions to implement an IRP (integrated resource planning) process do not exist in many countries. Hainan`s economy is growing rapidly with a concomitant increase in electricity demand. This is an ideal time in Hainan`s development to implement an IRP process. The challenge is for Hainan to develop institutions and incentive mechanisms for HEPCO (Hainan Electric Power Co.) to adopt cost-based pricing, run DSM programs, construct renewable generating plants, etc. One proposal is to great a Hainan government-wide IRP committee.

Energy Technology Data Exchange (ETDEWEB)

Originally designed exclusively for peak load covering, pumped storage plants are now faced with new challenges brought about by the deregulation of the electricity market and the substantial growth of wind power capacity. Today's pumped storage plants are started more frequently and often for shorter periods of time. The grid controlling tasks have increased the importance of the role played by this type of power plant and improved sales considerably. But the operational demands have grown substantially as well. This paper discusses the ensuing adaptation of power plant operation as well as options available to power plant operators. (orig.)

Science.gov (United States)

The Department of Defense is making significant investments to construct systems, built upon web services and their supporting technologies, that strive to achieve the goals of net-centricity. While these technologies address several of the traditional stumbling blocks to integration and interoperability, they leave issues of information management largely unaddressed. Indeed, the broad availability of these systems exacerbates, rather than reduces, stresses on our information management capabilities. This paper discusses the enterprise-level information management infrastructure objectives for providing net-centric military capabilities and more fundamental technical challenges derived from them.

Energy Technology Data Exchange (ETDEWEB)

Foinaven and Schiehallion/Loyal are the first oilfields West of Shetland (WoS). They were developed using Floating Production, Storage and Offloading (FPSO) technology in water depths of between 350m and 550m and arguably the harshest environmental conditions yet experienced offshore. Traditional project time scales were halved by shortening and overlapping the reservoir and facilities developments. This paper describes some of the challenges faced by the geotechnical engineers working on these projects and summarises lessons learnt from site investigations and the design and installation of foundations. (author)

British Library Electronic Table of Contents (United Kingdom)

Ontologies ? a form of structured and logically related knowledge or classification hierarchy embedded in a computer system ? are regarded by many scientists as having enormous promise for the consistent use and re-use of data. To realise this promise, however, is not straightforward. In this paper, based on ethnographic observation, we argue that the challenges for ontology building are ?social? as much as they are technical. By this we mean the routine work undertaken in the building process and the problems and difficulties entailed can be understood in terms of the practices of knowledge workers and the practical nature of ?sorting things out?. Getting a better sense of how, in practise, this work gets done gives a sense of the main challenges of building successful ontologies and how ...

Energy Technology Data Exchange (ETDEWEB)

Mercury is an element which, with its compounds, is hazardous and is found in hazardous wastes. In Order to develop suitable diagnostic and therapeutic agents for mercury exposure, we have sought alternative test systems. We have used the chelating agent 2,3-dimercaptopropane-1-sulfonate (DMPS, DIMAVAL{reg_sign}) for estimating the body burden of mercury in normal humans and in dental personnel in a developing country, and for detoxifying humans with mercurous chloride exposure. Use of the DMPS-mercury challenge test has shown that two-thirds of the mercury excreted in the urine of volunteers with dental amalgams appears to be derived from the mercury vapor released from their amalgams. The DMPS challenge test (300 mg, by mouth, after an 11 hr fast) was useful for monitoring dental personnel for mercury vapor exposure. The DMPS challenge test was given to 11 factory workers who make a skin lotion that contains mercurous ...

CERN Document Server

Statistical modelling for social researchers

Energy Technology Data Exchange (ETDEWEB)

This report describes and analyzes renewable energy seen as emerging markets, focusing on wind, solar and wave power. The conclusions are that: Wind and solar energy has reached critical mass. They are already large markets, and has a high growth rate. There are growth areas that may become among the world's largest industries in the future. This summary report and the underlying studies of wind, solar and wave power show that there is a large potential market for renewable energy sources. Wind power is already a market worth around 36.5 billion Euro. Solar energy is growing strongly and solar cells in 2008 had a market worth around 24 billion Euro. Wave power is at present a very small market and the in the actual development stage the potential of wave power is uncertain. But if the wave would become commercially viable, it could represent a significant part of the world's energy capacity, with associated large investments. In the foreseeable future, all areas have ...

Energy Technology Data Exchange (ETDEWEB)

Concept Exploration (CE) experiments within the Innovative Confinement Concept Program have a unique role which impacts their contributions to the development of fusion energy. As stated in the FESAC ''Report on Alternate Concepts:'' These [CE] programs are aimed at innovation and basic understanding of relevant scientific phenomena. The emphasis on innovation motivates their application to the search for a better fusion reactor configuration. In addition, because of their unique character the CE experiments offer excellent opportunities to couple fusion-plasma physics to other sciences. A recent example of coupling is the fusion self-organized plasmas to reconnection physics and extra-terrestrial plasmas. Perhaps of even greater importance is the education of the future scientists needed for developing fusion energy. The CE experiments, both at universities and national labs, are of a size students can ''get their hands ...

Energy Technology Data Exchange (ETDEWEB)

The Cement Bond Log Advisor is an expert system being developed to assist users in the design, evaluation, and interpretation of cement bond logs (CBL's). CBL's are produced by sonic tools run after the casing is cemented in a well to determine how well the cement is bonded to the casing and formation and whether a cement squeeze jog should be attempted. During the development of program, two particular challenges were encountered and resolved in ways that might be of general interest to developers of expert system applications for the petroleum industry. The first challenge was to find an efficient and effective method for guiding the user in correlating and interpreting the relationships between multiple sources of continuous visual data (the various waveforms making up the log output). Second, the nomographs, which correlate log amplitudes with cement compressive strength and are used in the log interpretation, were derive ...

Energy Technology Data Exchange (ETDEWEB)

This paper provides an overview of environmental cleanup at the Los Alamos National Laboratory (LANL) and some of the unique aspects and challenges. Cleanup of the 65-year old Department of Energy Laboratory is being conducted under a RCRA Consent Order with the State of New Mexico. This agreement is one of the most recent cleanup agreements signed in the DOE complex and was based on lessons learned at other DOE sites. A number of attributes create unique challenges for LANL cleanup -- the proximity to the community and pueblos, the site's topography and geology, and the nature of LANL's on-going missions. This overview paper will set the stage for other papers in this session, including papers that present: Plans to retrieve buried waste at Material Disposal Area B, across the street from oen of Los Alamos' commercial districts and the local newspaper; Progress to date and joint plans with WIPP for disposal of the ...

British Library Electronic Table of Contents (United Kingdom)

Climate change and limited primary energy resources require indigenous renewable electricity generation options to change the current coal-dominated power source matrix in China. The wind power is such a solution for the above challenges, and it still has large space for improvement in China. In this paper several critical factors related to Chinese wind power were studied in details, including the wind resources, the wind turbine industry and the policies from the Chinese government. Based on the study, the perspective of wind power in China was discussed. With outstanding advantages, the offshore wind power has a bright future in China, so its main characteristics are discussed. Based on the discussions, suggestions were given to improve the development of Chinese wind power, and the gov...

Energy Technology Data Exchange (ETDEWEB)

Three companies--Amerada Hess Ltd., Shell Expro (a 50/50 joint partnership between Shell and Esso) and Texaco--have joined forces in a project that will combine their expertise. The Triton project will allow three fields (Bittern, Guillemot West and Gullemot Northwest) to be developed simultaneously using subsea technology, with the wellheads on the seafloor and 68 miles (110 km) of flowlines taking oil and gas produced from the fields to a central floating production storage and offloading (FPSO) vessel. These fields are located in the central area of the North Sea, about 118 miles from Aberdeen in 295 ft of water. The paper discusses the development of the fields, subsea technology, technical challenges, laying the pipeline, and project completion.

British Library Electronic Table of Contents (United Kingdom)

This article explores the extent to which and how non-formal education (NFE) contributes to the development of a more diversified basic education system and thus to the achievement of EFA. It outlines the current nature of NFE, the frameworks provided by the EFA movement, and the evolution of reflection, policies and practices in NFE in relation to basic education as a whole. Based on significant developments in various countries across the South, the article also discusses some key challenges that ministries of education and their partners need to face in moving towards relevant and equitable diversity in education. The article posits that, despite the many problems faced by NFE, there is justification for building on its experiences and integrating these within a larger policy and system...

CERN Document Server

Integrated femtocell/macrocell networks, comprising a conventional cellular network overlaid with femtocells, offer an economically appealing way to improve coverage, quality of service, and access network capacity. The key element to successful femtocells/macrocell integration lies in its self-organizing capability. Provisioning of quality of service is the main technical challenge of the femtocell/macrocell integrated networks, while the main administrative challenge is the choice of the proper evolutionary path from the existing macrocellular networks to the integrated network. In this article, we introduce three integrated network architectures which, while increasing the access capacity, they also reduce the deployment and operational costs. Then, we discuss a number of technical issues, which are key to making such integration a reality, and we offer possible approaches to their solution. These issues include efficient frequency and ...

International Nuclear Information System (INIS)

Canada has undertaken to stabilize greenhouse gas emissions to 1990 levels by the year 2000. To achieve that objective, a voluntary challenge registry (VCR) plan was initiated by the federal and provincial governments to encourage industry, governments, and public sector to take voluntary actions that would contribute to the reduction of greenhouse gas emissions. The initiatives that CAPP member companies have taken were outlined in CAPP's 1995 Action Plan: Climate Change Voluntary Challenge, which was included with this report. The measures reported to date resulted in CO_2 reductions of 812,722 tonnes per year. The report provided a chronological review of CAPP actions in the field of climate changes since 1989, a summary of member action plans, and a listing of new technologies and their impact on greenhouse gas emissions.

CERN Document Server

The study of extragalactic planetary nebulae (EPN) is a rapidly expanding field. The advent of powerful new instrumentation such as the PN spectrograph has led to an avalanche of new EPN discoveries both within and between galaxies. We now have thousands of EPN detections in a heterogeneous selection of nearby galaxies and their local environments, dwarfing the combined galactic detection efforts of the last century. Key scientific motivations driving this rapid growth in EPN research and discovery have been the use of the PNLF as a standard candle, as dynamical tracers of their host galaxies and dark matter and as probes of Galactic evolution. This is coupled with the basic utility of PN as laboratories of nebula physics and the consequent comparison with theory where population differences, abundance variations and star formation history within and between stellar systems informs both stellar and galactic evolution. Here we pose some of the burning questions, discuss some of the ...

Energy Technology Data Exchange (ETDEWEB)

Onshore pipelines have traditionally been designed with a deterministic stress based methodology. The changing operating environment has however imposed many challenges to the pipeline industry, including heightened public awareness of risk, more challenging natural hazards and increased economic competitiveness. To meet the societal expectation of pipeline safety and enhance the competitiveness of the pipeline industry, significant efforts have been spent for the development of reliability-based design and assessment (RBDA) methodology. This paper will briefly review the technology development in the RBDA area and the focus will be on the progresses in the past years in standard development within the American Society of Mechanical Engineers (ASME) and the Canadian Standard Association (CSA) organizations. (author)

British Library Electronic Table of Contents (United Kingdom)

Several challenges currently exist for rational design of functional tissue engineering constructs within the host, which include appropriate cellular integration, avoidance of bacterial infections, and low inflammatory stimulation. This work describes a novel class of biodegradable, amphiphilic polyanhydrides with many desirable protein-material and cell-material attributes capable of confronting these challenges. The biocompatible amphiphilic polymer films were shown to release laminin in a stable and controlled manner, promote neural cell adhesion and differentiation, and evade inflammatory responses of the immune system. Using high-throughput approaches, it was shown that polymer chemistry plays an integral role in controlling cell?film interactions, which suggests that these polyanhyd...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

UK PubMed Central (United Kingdom)

The Cox proportional hazards model is the most widely used model for survival analysis because of its simplicity. The fundamental assumption in this model is the proportionality of the hazard function....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Energy Technology Data Exchange (ETDEWEB)

This report describes the results made in fulfillment of contract DE-FG26-02NT15451, ''Multicomponent Seismic Analysis and Calibration to Improve Recovery from Algal Mounds: Application to the Roadrunner/Towaoc Area of the Paradox Basin, Ute Mountain Ute Reservation, Colorado''. Optimizing development of highly heterogeneous reservoirs where porosity and permeability vary in unpredictable ways due to facies variations can be challenging. An important example of this is in the algal mounds of the Lower and Upper Ismay reservoirs of the Paradox Basin in Utah and Colorado. It is nearly impossible to develop a forward predictive model to delineate regions of better reservoir development, and so enhanced recovery processes must be selected and designed based upon data that can quantitatively or qualitatively distinguish regions of good or bad reservoir permeability and porosity between existing well control. ...

Science.gov (United States)

Describes general trends in the quality of rural education: equivalent rural and urban performance on national standardized tests and high school graduation rates but continuing rural deficits in college attendance and teacher qualifications. Discusses the below-average performance of southern rural schools, factors affecting rural students' college attendance, and the influence of changing labor markets. (SV)

International Nuclear Information System (INIS)

The philosophy of containing tritium and activated products very close to the source and of operating by remote techniques is justified by a comparison with other concepts on protection and availability points of view. Several design options are studied according to the optimization protection methodology of ICRP. Provided that an important technological development is accomplished, the utilization of robotics and the limitation of containment volumes should be generalized.

Energy Technology Data Exchange (ETDEWEB)

Modern particle accelerators offer new opportunities to dramatically reshape the way we think about nuclear energy, and challenge some of the thorniest problems linked to its industrial use, e.g. nuclear waste. A powerful proton accelerator driving a sub-critical fission reactor could be used for producing energy more safely and burning up the extra spent fuel which so far has been stored in geological repositories.

Science.gov (United States)

The properties of a nonviable, aqueous ether-extracted Brucela abortus preparation, Bru-Pel, are described. In addition to inducing a "virus-type" interferon response and protecting mice against challenge with otherwise lethal doses of Semliki Forest virus, Bru-Pel is demonstrated to have potent antitumor properties in mice. These antitumor effects appear to be mediated by an increase in nonspecific resistance similar to that seen with other experimental antitumor agents. PMID:728911

Energy Technology Data Exchange (ETDEWEB)

As oil supplies diminish, Britain will have to rely more and more on coal as one of the energy alternatives. To burn coal cleanly and efficiently coal will have to be converted into gas and liquid fuels to replace natural gas and oil. The research and development programme of the National Coal Board is directed towards meeting these new challenges. This paper outlines some of the Coal Board's current projects in the fields of industrial combustion, power generation, domestic combustion, coal gasification and coal liquefaction. 10 figs.

UK PubMed Central (United Kingdom)

We describe the architecture of LifeCode® (A-Life Medical, Inc.), a natural language processing system for free-text clinical information extraction, our methodology in applying LifeCode®...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundSeventy percent of urban populations in sub-Saharan Africa live in slums. Sustaining HIV patients in these high-risk and highly mobile settings is a major future challenge....Full Text Available

UK PubMed Central (United Kingdom)

Described are the changes to ICD-10-CM and PCS and potential challenges regarding their use in the US for financial and administrative transaction coding under HIPAA in 2013. Using author constructed...Full Text Available

Science.gov (United States)

Correlates between immunological parameters and protection against Bacillus anthracis infection in animals vaccinated with protective antigen (PA)-based vaccines could provide surrogate markers to evaluate the putative protective efficiency of immunization in humans. In previous studies we demonstrated that neutralizing antibody levels serve as correlates for protection in guinea pigs (S. Reuveny et al., Infect. Immun. 69:2888-2893, 2001; H. Marcus et al., Infect. Immun. 72:3471-3477, 2004). In this study we evaluated similar correlates for protection by active and passive immunization of New Zealand White rabbits. Full immunization and partial immunization were achieved by single and multiple injections of standard and diluted doses of a PA-based vaccine. Passive immunization was carried out by injection of immune sera from rabbits vaccinated with PA-based vaccine prior to challenge with B. anthracis spores. Immunized rabbits were challenged ...

Energy Technology Data Exchange (ETDEWEB)

The energy challenges of the next 30 years appear daunting and, in certain cases, in conflict with one another. Their complexity is such that one solution alone cannot provide a full answer. It is nevertheless equally clear that hydro-electricity, being renewable, proven, highly efficient, storable and with still very significant resource potential, possesses a unique combination of attributes which will aid decision-makers to plan and execute energy development with confidence.

UK PubMed Central (United Kingdom)

Summary20 years ago, in 1987, Edelson and co-workers published their first report on the effectiveness of a new procedure, called extracorporeal photochemotherapy (ECP), in patients...Full Text Available

International Nuclear Information System (INIS)

The Training Department at the Point Lepreau GS has been developing and improving its training for technical support staff. A generic set of objectives are being used as the basis for a systematic approach to training. The program covers general and job specific knowledge and skills using a mix of classroom instruction, mentoring and continuing training seminars. This paper describes experience, success and the challenges in the development, delivery and evaluation of the training program. (author)

British Library Electronic Table of Contents (United Kingdom)

A reciprocal relationship informing both research and practice is one of the primary goals in the emerging field of Mind, Brain, and Education (MBE), yet the field has little documentation and analysis of such collaborations. In this article, we present case studies of three research-practice partnerships taking place between scientists and educators. By comparing and contrasting these three partnerships we expect to illuminate common characteristics, challenges, and benefits that come with doing MBE work.

Science.gov (United States)

Sugarcane orange rust is an economically important disease in Florida and has caused yield losses in the major cultivar, CP 80-1743 since it was introduced in 2007. Orange rust has caused susceptible cultivars to be discarded from the CP-cultivar development program and is also causing yield losses....

Science.gov (United States)

Mission, threat and capabilities adaptations in the twenty-first century continue to change the tasks assigned to U.S. Army Infantry units. Traditional infantry tactical training does not prepare U.S. infantry forces for many of the tasks required in cont...

Energy Technology Data Exchange (ETDEWEB)

A new era for the field of Galactic structure is about to be opened with the advent of wide-area digital sky surveys. In this article, the author reviews the status and prospects for research for 3 new ground-based surveys: the Sloan Digital Sky Survey (SDSS), the Deep Near-Infrared Survey of the Southern Sky (DENIS) and the Two Micron AU Sky Survey (2MASS). These surveys will permit detailed studies of Galactic structure and stellar populations in the Galaxy with unprecedented detail. Extracting the information, however, will be challenging.

Science.gov (United States)

... 4 Joint Committee on Atomic Energy as a Model . . . . . ... Joint Committee on Atomic Energy as a Model ...

Wastenet

Institutional and organizational models ... Review individual centre institutional and organizational models in the light of the tasks to be performed by

Energy Technology Data Exchange (ETDEWEB)

The role of natural enemies in the regulation of populations is one of the major questions facing population ecologists. Simplification have led to two theoretical ways of incorporating the role of natural enemies in single ecological models: diffusion models and patch-type models. The predictions of the models are different because of the way variability is incorporated. Three equations are presented for diffusion models and one for patch models. Since the two types of models apply at different combinations of spatial and temporal scales, the right model(s) to choose for a particular study requires careful assessment. A continuing dialogue between experimentalists and theoreticians will lead to a better understanding of natural systems such as those that occur in biological control.

Science.gov (United States)

terms of 11) numerical models, 2D SPH simulations, and analytic models. The 1D model was useful for determining the evolution over very long timescales. ...

UK PubMed Central (United Kingdom)

Models can be useful at many different levels when considering complex issues such as biological control of mosquitoes. At an early stage, exploratory models are valuable in exploring the characteristics...Full Text Available

Science.gov (United States)

Engine model: An engine and governor model adapted from a heavy lift helicopter simulation provides a restistic time delay between aerodynamic rotor ...

Science.gov (United States)

The study surveyed urban women's use of information media and drew attention to the implications for women in leadership positions and non-formal education. A questionnaire containing structured and unstructured items was administered to 300 women resident at Nsukka urban town Enugu State, Nigeria. One hundred and twenty-five usable copies were used for the data analysis. The findings show that oral media are the most popular among women irrespective of level of education and type of occupation. The level of education influenced the use of radio and television. Popular radio and television programmes among women include newscasts, socio-cultural programmes, music and drama. Problems hindering women's use of radio and television include time constraint, poor reception, poor condition of available sets and lack of money for repairs among others. Based on these findings the implication for the achievement of the Universal Basic Education (UBE) objectives with reference to non-formal ...

Energy Technology Data Exchange (ETDEWEB)

The Hebron offshore drilling project in Atlantic Canada was discontinued in 2002 due to economic challenges. Chevron-Texaco has conducted small-scale studies to find ways to improve the project's viability. One of the main challenges facing this offshore drilling project is the issue of iceberg scour and its effect on seafloor equipment. This paper demonstrates how advances in ice engineering have resulted in new and cost-effective development concepts for: central gravity base structures; wellhead gravity base structures; floating production, storage and offloading (FPSO) subsea facilities; and, long subsea tieback and trench optimization. New studies have provided a better understanding of ice contact pressures, drift velocities, iceberg management and interaction processes. New designs for gravity base structures can reduce wave loads. The selection of a new development concept is determined by economic viability, capital cost, ...

Energy Technology Data Exchange (ETDEWEB)

This paper describes the challenges involved in the construction of a mid-rise housing development in Boston, Massachusetts, during which the development team elected to upgrade the initial design criteria from Minimum Building Code to Energy Star and Leadership in Energy and Environmental Design (LEED) certification. The various constraints imposed on the development were discussed, including constraints imposed by the involvement of substantial public funds as well as the constraints imposed by various funding sources that were approached to leverage energy efficiency and green building investment via competitive grant solicitations. Building owner and utility cost management priorities were outlined along with details of central mechanical system selection. Issues concerning isolation and compartmentalization were examined along with indoor pollution source control. A building load analysis was presented as well as details of daily heating and cooling ...

CERN Document Server

Resource coordination and interference management is the key to achieving the benefits of femtocell networks. Over-the-air signaling is one of the most effective means for distributed dynamic resource coordination and interference management. However, the design of this type of signal is challenging. In this letter, we address the challenges and propose an effective solution, referred to as coded single-tone signaling (STS). The proposed coded STS scheme possesses certain highly desirable properties, such as no dedicated resource requirement (no overhead), no near-and-far effect, no inter-signal interference (no multi-user interference), low peak-to-average power ratio (deep coverage). In addition, the proposed coded STS can fully exploit frequency diversity and provides a means for high quality wideband channel estimation. The coded STS design is demonstrated through a concrete numerical example. Performance of the proposed coded STS is ...

International Nuclear Information System (INIS)

This book deals with organizations that operate in high hazard industries, such as the nuclear power, aviation, oil and chemical industry organisations. The society puts a great strain on these organisations to rigorously manage the risks inherent in the technology they use and the products they produce. In this book, an organisational psychology view is taken to analyse what are the typical challenges of daily work in these environments. The analysis is based on a literature review about human and organisational factors in safety critical industries, and on the interviews of Finnish safety experts and safety managers from four different companies. In addition to this, personnel interviews conducted in the Finnish nuclear power plants are utilised. The authors come up with eight themes that seem to be common organizational challenges cross the industries. These include e.g. how does the personnel understand the risks and what is the right level ...

Energy Technology Data Exchange (ETDEWEB)

The Canadian Association of Petroleum Producers (CAPP) represents about 170 crude oil and natural gas exploration, development and production companies in regulatory hearings and legal proceedings. Its principal role is to enhance the economic well-being and sustainability of the Canadian upstream petroleum industry. This presentation explores the role that information technology (IT) plays in knowledge and information management and how this role relates to meeting Canada`s target for greenhouse gas emissions reductions set by the Kyoto Protocol. Actions such as the Voluntary Challenge Registry (VCR) and emissions reductions trading are re-visited and the information requirements associated with these actions are highlighted. It is shown that among others, emissions databases between jurisdictions (provincial, national, international) have to be integrated, reduction claims must be tracked, verified and cross-referenced to eliminate double counting, comprehensive ...