Realization that dental caries is a reversible, dynamic biochemical event at a micron level has changed the way the profession recognizes the caries disease and the caries lesion. The diagnosis of dental...Full Text Available
In order to study the intragenic profiles of active transcription, we determined the relative levels of active RNA polymerase II present at the 3′- and 5′-ends of 261 yeast genes by...Full Text Available
Type II diabetes mellitus (T2DM) is often accompanied by non-alcoholic steatohepatitis (NASH) and associated with hypercholesterolemia, i.e. increased levels of plasma low-density...Full Text Available
The in vivo photochemical activity of photosystem II was inferred from modulated chlorophyll fluorescence and photoacoustic measurements in intact leaves of several plant species (Lycopersicon...Full Text Available
Woolfolk, C. A. (University of Washington, Seattle). Reduction of inorganic compounds with molecular hydrogen by Micrococcus lactilyticus. II. Stoichiometry with inorganic...Full Text Available
A structurally conserved element, the trigger loop, has been suggested to play a key role in substrate selection and catalysis of RNA polymerase II (pol II) transcription elongation. Recently resolved...Full Text Available
The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1...Full Text Available
DNA from the peripheral blood mononuclear cells of 17 different individuals infected with human T-cell lymphoma/leukemia virus type II (HTLV-II) was successfully amplified by the polymerase chain reaction...Full Text Available
Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions. These synthesized metal(II)...Full Text Available
PRESTO-II is a computer code developed to evaluate possible health effects from shallow land disposal of low level radioactive wastes. PRESTO-PREP is a data preprocessor that has been developed to expedite the formation of input data sets for PRESTO-II. PRESTO-PREP utilizes a library of nuclide and risk-specific data. Given an initial waste inventory, the code creates the radionuclide portion of the associated input data set for PRESTO-II. 2 references.
The relationship between serum PG I, PG IIlevels and extent of atrophic gastritis was examined. The subjects were 64 patients (male: 32, female: 32, 51.9 years old on average) with established diagnosis of either atrophic gastritis or normal. In the X-ray gastric examination, Fuji Computed Radiography (FCR) was used to obtain clear-cut images of the gastric area. Concerning the serum PG I level, patients in the group with atrophic gastritis showed lower levels than those of the people in the group with no atrophic change, but the variation was wide, and no definite tendency was seen in the relationship between the atrophic change and the serum PG I levels. Concerning the serum PG IIlevel, as the atrophic change progresses, the serum PG IIlevel tended to increase gradually. A significant reduction ...
The relationship between serum PG I, PG IIlevels and extent of atrophic gastritis was examined. The subjects were 64 patients (male: 32, female: 32, 51.9 years old on average) with established diagnosis of either atrophic gastritis or normal. In the X-ray gastric examination, Fuji Computed Radiography (FCR) was used to obtain clear-cut images of the gastric area. Concerning the serum PG I level, patients in the group with atrophic gastritis showed lower levels than those of the people in the group with no atrophic change, but the variation was wide, and no definite tendency was seen in the relationship between the atrophic change and the serum PG I levels. Concerning the serum PG IIlevel, as the atrophic change progresses, the serum PG IIlevel tended to increase gradually. A significant reduction ...
Angiotensin II (Ang II) is a key proapoptotic factor in fibrotic tissue diseases. However, the mechanism of Ang-II-induced cell death in endothelial cells has not been previously elucidated....Full Text Available
The subfornical organ is a major receptor area for one of the principal stimuli of thirst, the octapeptide, angiotensin II. In conscious water-sated rats, the authors examined the effects of intravenous infusion of angiotensin II on the rate of glucose utilization in the subfornical organ and in structures anatomically and functionally connected with it. Angiotensin II produced pressor and drinking responses and increased glucose utilization selectively in the subfornical organ and pituitary neural lobe and in no other brain structure. Treatment with the angiotensin II antagonist, sar1-leu8-angiotensin II, before intravenous administration of angiotensin II prevented metabolic stimulation of the subfornical organ and neural lobe. Captopril, an inhibitor of angiotensin-converting enzyme, reduced subfornical organ glucose metabolism to a level ...
Exposure of albumin to Cu(II) (10-100 microM) and ascorbate (0.1-2 mM) results in extensive molecular modifications, indicated by decreased fluorescence and chain breaks. The rate of utilization of...Full Text Available
ObjectivesThe updated Rome III criteria for pediatric functional gastrointestinal disorders (FGIDs) include new FGID categories and changes to the Rome II criteria...Full Text Available
Interleukin 2 (IL-2) and B-cell growth factors I and II (BCGF I and BCGF II) are lymphokines produced by T cells that play a major role in T- and B-cell cooperation. Peripheral blood lymphocytes from...Full Text Available
Aminopeptidase II, one of the two major aminopeptidases in the giant alga Chara australis, was partially purified. Its molecular weight was estimated to be about 80,000 by gel permeation...Full Text Available
BackgroundThe binding of peptide fragments of antigens to class II MHC is a crucial step in initiating a helper T cell immune response. The identification of such peptide epitopes...Full Text Available
BackgroundPromoter region plays an important role in determining where the transcription of a particular gene should be initiated. Computational prediction of eukaryotic Pol II promoter...Full Text Available
Rotazyme II, which is a shorter version of Rotazyme (less than 3 h), was compared with electron microscopy and Rotazyme for sensitivity and specificity on 229 human stool specimens. Compared with electron...Full Text Available
BackgroundPerfluorocarbons (PFC) are used to improve gas exchange in diseased lungs. PFC have been shown to affect various cell types. Thus, effects on alveolar type II (ATII) cells...Full Text Available
ATP-binding cassette A3 (ABCA3) is a lipid transport protein required for synthesis and storage of pulmonary surfactant in type II cells in the alveoli. Abca3 was conditionally deleted...Full Text Available
Cytokinesis in animal and fungal cells utilizes a contractile actomyosin ring (AMR). However, how myosin II is targeted to the division site and promotes AMR assembly, and how the AMR coordinates with...Full Text Available
Anaerobic reactions of Rhus vernicifera laccase and its type-2 copper-depleted derivatives with hexacyanoferrate(II) were investigated by absorption and e.s.r. spectroscopy. When native laccase was...Full Text Available
Photobilirubin II, a stereoisomer of bilirubin, binds to human serum albumin at a single binding site (K = 2.2 x 10(6)M-1), presumably the high-affinity bilirubin-binding site. Binding in the secondary...Full Text Available
The identification of MHC class II restricted peptide epitopes is an important goal in immunological research. A number of computational tools have been developed for this purpose, but there is a lack...Full Text Available
In the RIR (Risk-informed Regulation), PSA (Probabilistic Safety Assessment) plays a major role because it provides overall risk insights for the regulatory body and utility. Therefore, the scope, the level of details and the technical adequacy of PSA, i.e. the quality of PSA is to be ensured for the successful RIR. To improve the quality of Korean PSA, we evaluate the quality of the KSNP (Korean Standard Nuclear Power Plant) internal full-power PSA model based on the 'ASME PRA Standard' and the 'NEI PRA Peer Review Process Guidance.' As a working group, PSA experts of the regulatory body and industry also participated in the evaluation process. It is finally judged that the overall quality of the KSNP PSA is between the ASME Standard Capability Category I and II. We also derive some items to be improved for upgrading the quality of the PSA up to the ASME Standard Capability Category ...
Fatty acid biosynthesis is crucial for all living cells. In contrast to higher organisms, bacteria use a type II fatty acid synthase (FAS II) composed of a series of individual proteins, making...Full Text Available
System-level-operational testing of the ETX-II test-bed electric vehicle is described and the results discussed. Because the traction battery is a major factor in the performance of an electric vehicle, previously reported work on the sodium-sulfur battery designed for use with the ETX-II is reviewed in detail. Chassis dynamometer performance of the test-bed vehicle met or exceeded design goals and compared reasonably well with SIMPLEV computer modeling results. Areas are identified wherein further work is needed to establish a firmer basis for comparison of the simulation and the observed results.
Active Activator (Ac) elements undergo mutations to become nonautonomous Dissociation (Ds) elements at a low frequency. To understand...Full Text Available
The palladium(II) and platinum(II)complexes(where, (M(L){sub 2}X{sub 2}), M=Pd(II), Pt(II); L=isoxazole (isox), 3, 5-dimethylisoxazole(3, 5-diMeisox), 3-methyl, 5-phenylisoxazole(3-Me, 5-Ph-isox), and 4-amino-3, 5-di-methylisoxazole (4-ADI); X=Cl, Br) with isoxazole and its derivatives were investigated on antitumor activity by MM2 and EHMO calculation. Because for all the complexes the {sigma}MO energy level (E{sub {sigma}}{sub (M-X)} between d{sub x}{sup 2}{sub -y}{sup 2} orbital of central metal and p{sub x} orbital of halogen atom is less than {sigma}MO energy level E{sub {sigma}}{sub (M-N)} between d{sub x}{sup 2}{sub -y}{sup 2} orbital of central metal and p{sub x} orbital of N atom, without exception. And judging, from the lower E{sub {sigma}}{sub (M-X)} value in trans, the bonding strength was found to be weaker in trans isomer than in cis. For the ...
Aug 15, 2002 ... In Section II, we describe the routing and transceiver power model used ... In our power model, we assume a certain non-zero minimum level of ...
We determined the chromosomal localization and structure of the gene encoding human type II inosine 5{prime}-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205), an enzyme associated with cellular proliferation, malignant transformation, and differentiation. Using polymerase chain reaction (PCR) primers specific for type II IMPDH, we screened a panel of human-Chinese hamster cell somatic hybrids and a separate deletion panel of chromosome 3 hybrids and localized the gene to 3p21.1{yields}p24.2. Two overlapping yeast artificial chromosome clones containing the full gene for type II IMPDH were isolated and a physical map of 117 kb of human genomic DNA in this region of chromosome 3 was constructed. The gene for type II IMPDH was localized and oriented on this map and found to span no more than 12.5 kb.
Full text of publication follows: Large-scale problems such as nuclear waste disposal are increasingly recognized to be interconnected to small scale-mechanisms. Thus, synchrotron-based high-resolution analytical X-ray probes become important tools for exploring the micro-scale chemical reactivity of heterogeneous barrier materials used in nuclear waste repositories. In this study the layout of the micro-XAS beamline at the Swiss Light Source (SLS) will be presented. The beamline is optimized towards micro beam experiments ({approx}1 x 1 {mu}m{sup 2}) in the hard-X-ray regime (4 - {approx}22 keV) and allows to combine micro X-ray fluorescence (micro-XRF), micro X-ray absorption spectroscopy (micro- XAS), and micro X-ray diffraction (micro-XRD) investigations with radioactive samples. Furthermore, the potential of micro-XRF/XAS/XRD for acquiring spatially resolved molecular level information on the speciation and structural coordination ...
The CDF II eXtremely Fast Tracker (XFT) is the trigger processor which reconstructs charged particle tracks in the CDF II central outer tracking chamber. The XFT tracks are also extrapolated to the electromagnetic calorimeter and muon chambers and are associated to electromagnetic clusters and muon stubs to generate trigger electron and muon candidates. The steady increase of the Tevatron instantaneous luminosity and the resulting higher occupancy of the chamber demanded an upgrade of the original system, which performed tracking only in the transverse plane of the chamber and was consequently affected by a significant level of fake tracks. In the upgraded XFT, tracking is reinforced by using additional data from the stereo layers of the chamber to reduce the level of fake tracks and to perform three-dimensional track reconstruction. A review of this upgrade is presented.
A CRC cooperative program was conducted to determine the difference in octane requirements between technical raters and 'customers' (the general driving public). The tests were conducted in two phases, with the second being a repeat of the first to verify the results obtained. The trained raters used the CRC E-15 procedure to determine the octane requirement of the vehicles while the customers' perception and objection to knock were determined through the use of a questionnaire. The customers' responses (perception and objection level) were based upon audible knock, acceleration performance, and after-run on a series of full-boiling-range customer/rater unleaded (FBRCU) reference-fuels. Data were analyzed from 168 1988-1991 model-year vehicles, with 126 of these tested in Phase II. The results showed that the customers, objections and perceptions were overwhelmingly based on knock, rather ...
The temporal patterns of protein phosphorylation in the adrenal glomerulosa cell were analysed by two-dimensional electrophoresis after stimulation with 10 nM-angiotensin II or various agents [10 nM-12-O-tetradecanoylphorbol...Full Text Available
Type II NAD(P)H:quinone oxidoreductases (NDH-2) catalyze the two-electron transfer from NAD(P)H to quinones, without any energy-transducing site. NDH-2 accomplish the turnover of NAD(P)H, regenerating...Full Text Available
PurposeRTOG protocol 95-17 was a phase I/II trial to evaluate multi-catheter brachytherapy as the sole method of adjuvant breast radiotherapy for stage I/II breast...Full Text Available
Several closely related Mn(II)-oxidizing alpha-Proteobacteria were isolated from very different marine environments: strain SI85-9A1 from the oxic/anoxic interface of a stratified...Full Text Available
The nature of binding of Ru(phen) 2+ (I), Ru(bipy) 2+ (II), Ru(terpy) 2+ (III) (phen = 1,10-phenanthroline, bipy 3 = 2,2'-bipyridyl, 3 terpy = 2,2'2," - 2 terpyridyl) to DNA, poly[d(G-C)] and poly[d(A-T)]...Full Text Available
The properties of a helium film on the surface of solid parahydrogen are investigated. It is shown that wetting of the solid hydrogen by the liquid helium occurs. The transport velocities along the He II film on the solid parahydrogen surface are measured in broad temperature, film height, and level difference ranges. It is shown that the transport velocity in this case has the least value as compared with its value on other substrates. The thickness of the helium-saturated film is determined on the solid hydrogen surface on the basis of the data obtained, and the value is in good agreement with the results of a computation performed within the framework of the Frenkel' theory.
This handbook breaks down the complex field of nuclear reactor calculations into major steps. Each step presents a detailed analysis of the problems to be solved, the parameters involved, and the elaborate computer programs developed to perform the calculations. This book bridges the gap between nuclear reactor theory and the implementation of that theory, including the problems to be encountered and the level of confidence that should be given to the methods described. Volume II: Monte Carlo Calculations for Nuclear Reactors. In-Core Management of Four Reactor Types. In-Core Management in CANDU-PHW Reactors. Reactor Dynamics. The Theory of Neutron Leakage in Reactor Lattices. Index.
This study aimed to correlate the efficiency of enzymatic hydrolysis of the cellulose contained in a sugarcane bagasse sample pretreated with dilute H(2)SO(4) with the levels of independent variables such as initial content of solids and loadings of enzymes and surfactant (Tween 20), for two cellulolytic commercial preparations. The preparations, designated cellulase I and cellulase II, were characterized regarding the activities of total cellulases, endoglucanase, cellobiohydrolase, cellobiase, ?-glucosidase, xylanase, and phenoloxidases (laccase, manganese and lignin peroxidases), as well as protein contents. Both extracts showed complete cellulolytic complexes and considerable activities of xylanases, without activities of phenoloxidases. For the enzymatic hydrolyses, two 2(3) central composite full factorial designs were employed to evaluate the effects caused by the initial content of solids (1.19-4.81%, w/w) and ...
Equinovarus of the foot is the most common lower extremity deformity following traumatic brain injury. We evaluated outcomes of the split anterior tibialis tendon transfer (SPLATT) for correction of equinovarus in 47 patients with hemiplegic traumatic brain injury and specifically studied differences in outcomes with two tendon fixation techniques. Seventeen patients constituting Group I underwent fixation with one technique and 30 constituting Group II had another technique. Patients in both groups had appropriate procedures based on dynamic electromyography and gait analyses. Both groups were demographically comparable. All 47 feet were corrected to plantigrade position. Thirty-six of 47 patients became brace-free at final followup. There was a notable decrease in the use of ambulatory aids and ambulatory status improved in both groups. There were three fixation-related complications in Group I and none in Group II. Surgical correction of the ...
PURPOSE: To determine the recommended dose of radiotherapy when combined with full-dose gemcitabine and erlotinib for unresected pancreas cancer. METHODS AND MATERIALS: Patients with unresected pancreatic cancer (Zubrod performance status 0-2) were eligible for the present study. Gemcitabine was given weekly for 7 weeks (1,000 mg/m(2)) with erlotinib daily for 8 weeks (100 mg). A final toxicity assessment was performed in Week 9. Radiotherapy (starting at 30 Gy in 2-Gy fractions, 5 d/wk) was given to the gross tumor plus a 1-cm margin starting with the first dose of gemcitabine. A standard 3 plus 3 dose escalation (an additional 4 Gy within 2 days for each dose level) was used, except for the starting dose level, which was scheduled to contain 6 patients. In general, Grade 3 or greater gastrointestinal toxicity was considered a dose-limiting toxicity, except for Grade 3 anorexia or Grade 3 fatigue alone. RESULTS: A total of ...
Sensory rhodopsins (SRs) belong to a subfamily of heptahelical transmembrane proteins containing a retinal chromophore. These photoreceptors mediate the cascade of vision in animal eyes and phototaxis...Full Text Available
We have previously observed that auxin can act as a repressor of the wound-inducible activation of a chimeric potato proteinase inhibitor II-CAT chimeric gene (pin2-CAT) in transgenic...Full Text Available
The Ty transposable elements of Saccharomyces cerevisiae form a heterogeneous family within which two broad structural classes (I and II) exist. The two classes differ by two large substitutions and...Full Text Available
Molecular Misreading (MM) is the inaccurate conversion of genomic information into aberrant proteins. For example, when RNA polymerase II transcribes a GAGAG motif it synthesizes at low frequency RNA...Full Text Available
Highly polymorphic genes with central roles in lymphocyte mediated immune surveillance are grouped together in the major histocompatibility complex (MHC) in higher vertebrates. Generally, across vertebrate...Full Text Available
The article is divided into three sections: (i) an overview of the main ethical models in public health (theoretical foundations); (ii) a summary of several published frameworks for public health ethics...Full Text Available
The effect of Escherichia coli lipopolysaccharide (LPS) on the expression of major histocompatibility complex (MHC) class II molecules by bovine mammary macrophages was examined. The ability of LPS-treated...Full Text Available
The world's oceans contain a complex mixture of micro-organisms that are for the most part, uncharacterized both genetically and biochemically. We report here a metagenomic study of the marine planktonic...Full Text Available
The clinical management of adults with low-grade gliomas (LGGs) remains a challenge. There is no curative treatment, and management of individual patients is a matter of deciding optimal timing as well...Full Text Available
Peptide toxins with high affinity, divergent pharmacological functions, and isoform-specific selectivity are powerful tools for investigating the structure-function relationships of voltage-gated...Full Text Available
Six related Staphylococcus phages spontaneously produced various abnormal head and tail structures: (i) giant capsids which were tailed and apparently contained nucleic acid; (ii) regular and irregular...Full Text Available
Sedentary adult males with spinal lesions, all habitual wheelchair users, were allocated to exercise (n = 11) and control (n = 4) groups. A Cybex II dynamometer was used to assess peak power, average...Full Text Available
BackgroundPeroxiredoxins (Prxs) have recently been suggested to have a role in tumorigenesis.MethodsWe studied the expression of Prx I-VI and their...Full Text Available
We designed a multicenter study to compare tobramycin/clindamycin to imipenem/cilastatin for intra-abdominal infections. We included the Acute Physiology and Chronic Health Evaluation (APACHE II) index...Full Text Available
SUMMARYReplication timing is frequently discussed superficially in terms of its relationship to transcriptional activity via chromatin structure. However, so little is known about...Full Text Available
BackgroundThe Class II DNA transposons are mobile genetic elements that move DNA sequence from one position in the genome to another. We have previously demonstrated that the naturally...Full Text Available
Human longevity is in part genetically determined, and the insulin/IGF-1 signal transduction (IIS) pathway has consistently been implicated. In humans, type 2 diabetes is a frequent disease that results...Full Text Available
PurposePlatinum and taxane compounds have demonstrated activity in uterine carcinosarcoma (malignant mixed Mullerian tumor). Ifosfamide plus paclitaxel is the regimen with established...Full Text Available
BackgroundThe lack of adequate randomized clinical trials (RCT) has hindered identification of new therapies that are safe and effective for patients with primary focal segmental...Full Text Available
The mechanism of cytokinesis has been difficult to define because of the short duration and the temporal-spatial dynamics involved in the formation, activation, force production, and disappearance of...Full Text Available
Endosomal sorting complexes required for transport (ESCRTs) are heteromeric protein complexes required for multivesicular body (MVB) morphogenesis. ESCRTs I, II, III and III-associated are ubiquitous...Full Text Available
Obesity and metabolic syndrome result from excess calorie intake and genetic predisposition and are mechanistically linked to type II diabetes and accelerated body aging; abnormal nutrient and insulin...Full Text Available
SummaryThe general transcription factor TFIID is a large multi-subunit complex required for the transcription of most protein-encoding genes by RNA polymerase II. Taking advantage...Full Text Available
Type II collagen-induced arthritis (CIA) in mice is an autoimmune experimental model for rheumatoid arthritis. Susceptibility to CIA is associated with certain major histocompatibility complex class...Full Text Available
Mammals possess multiple insulin-like growth factor (IGF) binding proteins (IGFBPs), and related proteins, that modulate the activity of insulin/IGF signalling (IIS), a conserved neuroendocrine signalling...Full Text Available
Rationale: Human data suggest that the incidence of acute lung injury is reduced in patients with type II diabetes mellitus. However, the mechanisms by which diabetes confers protection...Full Text Available
The cytokine interleukin-7 (IL-7) has essential growth activities that maintain the homeostatic balance of the immune system. Little is known of the mechanism by which IL-7 signaling regulates metabolic...Full Text Available
The importance of a properly functioning and well-balanced immune system for maintaining health has become strikingly evident over the past decades. Roughly since World War II, there has been an apparent...Full Text Available
An aqueous house dust mite extract was separated by SDS-PAGE and transferred to nitrocellulose membranes by Western Blotting. Two major allergens, Der pI and Der pII associated with the mite faeces...Full Text Available
Microarray data has a high dimension of variables but available datasets usually have only a small number of samples, thereby making the study of such datasets interesting and challenging. In the task...Full Text Available
Endometrial biopsies were taken for histological assessment from 97 cows which calved in a commercial dairy herd between April and August 1984. The main objectives of this study were to analyze the...Full Text Available
Ligand exchange of hydrated metal complexes is common in chemical and biological systems. Using the ultrafast T-jump, we examined this process, specifically the transformation of aqua cobalt (II) complexes...Full Text Available
Purpose.The hypothesis that drivers with homonymous hemianopia (HH) would take a lane position that increased the safety margin on their blind side was tested with a driving simulator.Methods.Twelve...Full Text Available
Uncoupling protein 2 (UCP2) maps to a region on distal mouse chromosome 7 that has been linked to the phenotypes of obesity and type II diabetes. We recently reported that UCP2 expression is increased...Full Text Available
Systemic administration of lipopolysaccharide (LPS), which causes endotoxemia and systemic inflammation, has been reported to induce expression of the gene for type II inducible nitric oxide synthase...Full Text Available
BackgroundThe rate of emergence of human pathogens is steadily increasing; most of these novel agents originate in wildlife. Bats, remarkably, are the natural reservoirs of many...Full Text Available
The photosynthetic activity of the green alga Scenedesmus quadricauda was investigated during synchronous growth in light/dark cycles. The rate of O2 evolution increased...Full Text Available
Benzodiazepine withdrawal anxiety is associated with potentiation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) currents in hippocampal CA1 pyramidal...Full Text Available
BackgroundThere is no consensus as to the prognostic model for brachytherapy of tongue carcinoma. This study was designed to evaluate the prognostic factors for local control based...Full Text Available
BackgroundHigh intake of sugar-sweetened beverages in childhood is linked to increased risk of obesity and type II diabetes later in life. Using three nationally representative surveys...Full Text Available
Alterations in basement membrane components, notably proteoglycans, in a rat model of polycystic kidney disease have been investigated. Rats were fed phenol II (2-amino-4-hydroxyphenyl-5-phenyl thiazole)...Full Text Available
The protein kinase CK2 (formerly casein kinase II) is thought to be involved in light-regulated gene expression in plants because...Full Text Available
Pharmacologic or genetic deletion of components of the renin-angiotensin system leads to postnatal kidney injury, but the roles of these components in kidney development are unknown. To test the hypothesis...Full Text Available
PurposeWe previously reported a randomized phase II clinical trial combining a poxvirus-based vaccine encoding PSA with radiotherapy in patients with localized prostate...Full Text Available
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and...Full Text Available
We proposed a faster pedigree-based generalized multifactor dimensionality reduction algorithm, called PedG-MDR II (PII), to detect gene-gene interactions underlying complex traits. Inherited...Full Text Available
We have measured the isotope shifts of some dipole transitions between excited states of the even strontium isotopes 88 and 86 by applying the technique of Doppler-free intermodulated optogalvanic spectrocopy to a heat-pipe discharge. We were also able to investigate the isotope shift of the Sr II resonance line at 4216.6 A optogalvanically in the mentioned pair of isotopes. Because the 5 snf"1F_3 series appear to have zero level isotope shifts for n>=6, we can give residual level isotope shifts (RLIS) of several odd-parity states of sup(88,86) Sr I. The RLIS of the 5 snp "1P_1 series show pronounced configuration mixing around n=7. (orig.).
This article is a story of networking of palliative care at the corporate level. This gives an insight that if you have will and dedication then you can imagine and make it true that networking can...Full Text Available
Perinatal exposure to cadmium (Cd) or methylmercury (MeHg) results in impaired neurodevelopment. Thyroid hormone is essential for normal brain development. However, the issue whether Cd or MeHg, especially at low doses, interrupts thyroid hormone action remains to be investigated. In the present study, effects of perinatal exposure to low levels of Cd or MeHg on thyroid hormone metabolism were examined using metallothionein I and II (MT-I/II) null or wild-type neonatal mice. Dams were exposed to 10 mg/L water of Cd or 5 mg/kg chow of MeHg from gestational day 0 to post-natal day 10 (PND 10). Sera, livers and brains were collected from neonates on PND 10. Iodothyronine deiodinase activities and serum thyroxine (T4) concentrations were measured. MeHg exposure failed to induce changes in serum T4 levels and liver type 1 deiodinase (D1) and brain type 2 deiodinase (D2) activities regardless of the MT ...
Abnormal fat metabolism plays an important role in the pathogenesis of obesity-related type 2 diabetes mellitus. This study examined whether free fatty acid levels (FFAs), like insulin levels, oscillate...Full Text Available
AbstractEffects of dietary biotin supplementation on serum biotin levels and physical properties of sole horn of 40 Holstein cows were evaluated. The mean serum biotin level in biotin-supplemented...Full Text Available
Background: The causes of elevated B-Type natriuretic peptide (BNP) levels are multifactorial. Renal dysfunction has been shown to affect BNP levels in some studies and...Full Text Available
Objectives:There is no study about correlation between vitamin D serum level and multiple sclerosis (MS) in Iran. So in this survey, we investigated the serum level of 25-hydroxy...Full Text Available
The electronic structure and properties of the cubic Laves phase (C15) compounds ZrZn_2 and ZrV_2 have been determined using our all-electron full-potential linearized-augmented-plane-wave (FLAPW) method for bulk solids. The computations were performed in two stages: (i) self-consistent warped muffin tin and (ii) self-consistent full potential. Spin-orbit coupling was included after either stage. The effects of the inclusion of the nonspherical terms inside the muffin tins on the eigenvalues is found to be small (of order 1 mRy). However, due to the fact that some of the bands near the Fermi level are flat, this effect leads to a much higher value of the density of states at E/sub F/ in ZnZr_2. The most important difference between the materials ZrZn_2 and ZrV_2 is the position of the d bands derived from the Zr and V atoms. Consequently, these materials have completely different Fermi surfaces. We have ...
The electronic structure and properties of the cubic Laves phase (C15) compounds ZrZn/sub 2/ and ZrV/sub 2/ have been determined using our all-electron full-potential linearized-augmented-plane-wave (FLAPW) method for bulk solids. The computations were performed in two stages: (i) self-consistent warped muffin tin and (ii) self-consistent full potential. Spin-orbit coupling was included after either stage. The effects of the inclusion of the nonspherical terms inside the muffin tins on the eigenvalues is found to be small (of order 1 mRy). However, due to the fact that some of the bands near the Fermi level are flat, this effect leads to a much higher value of the density of states at E/sub F/ in ZnZr/sub 2/. The most important difference between the materials ZrZn/sub 2/ and ZrV/sub 2/ is the position of the d bands derived from the Zr and V atoms. Consequently, these materials have completely ...
This study evaluated whether differences in design of 3-dimensional polylactic acid barriers (EPi-Guide and Guidor) would influence hard tissue results in the treatment of Grade II furcations in humans. A multicenter study was conducted, using 40 patients with moderate to advanced bilateral chronic adult periodontitis of the mandibular first or second molars. After flap access, debridement, and root preparation, surgical bone level measurements were taken and membranes were placed on a random basis. Surgical reentry occurred at 1 year. Data collected from all 3 investigative centers were pooled and analyzed using an analysis of variance appropriate for a counterbalancing design. Both barrier materials resulted in significant gains of attachment level and defect reduction. The composite reduction in the vertical component of the osseous defects was greater in the sites treated with Epi-Guide as compared to those treated with ...
The possible role of space-like objects in elementary particle physics (and in quantum mechanics) is reviewed and discussed, mainly by exploiting the explicit consequences of the peculiar relativistic mechanics of Tachyons. Particular attention is paid: (i) to tachyons as the possible carriers of interactions; (ii) to the possibility of ''vacuum decays'' at the classical level; (iii) to a Lorentz-invariant bootstrap model; (iv) to the apparent shape of the tachyonic elementary particles and its possible connection with the de Broglie wave-particle dualism. (author).
The purpose of this paper is to describe instrumentation and control (I C) system improvements at Experimental Breeder Reactor 11 (EBR-11). The improvements are focused on three objectives; to keep the reactor and balance of plant (BOP) I C systems at a high level of reliability, to provide diagnostic systems that can provide accurate information needed for analysis of fuel performance, and to provide systems that will be prototypic of I C systems of the next generation of liquid metal reactor (LMR) plants.
The purpose of this paper is to describe instrumentation and control (I&C) system improvements at Experimental Breeder Reactor 11 (EBR-11). The improvements are focused on three objectives; to keep the reactor and balance of plant (BOP) I&C systems at a high level of reliability, to provide diagnostic systems that can provide accurate information needed for analysis of fuel performance, and to provide systems that will be prototypic of I&C systems of the next generation of liquid metal reactor (LMR) plants.
This document, the Standards/Requirements Identification Document (S/RID) Phase 2 Assessment Report for the subject facility, represents the results of a Performance Assessment to determine whether procedures containing S/RID requirements are fully implemented by field personnel in the field. It contains a summary report and three attachments; an assessment schedule, performance objectives, and assessments for selected functional areas.
The 3 MW TRIGA Mark-II research reactor of Bangladesh Atomic Energy Commission (BAEC) has been operating since September 14, 1986. The reactor is used for radioisotope production ("1"3"1I, "9"9"mTc, "4"6Sc), various R and D activities and manpower training. The reactor has been operated successfully since it's commissioning with the exception of a few reportable incidents. Of these, the decay tank leakage incident of 1997 is considered to be the most significant one. As a result of this incident, reactor operation at full power under forced-convection mode remained suspended for about 4 years. During that time, the reactor was operated at a power level of 250 kW so as to carry out experiments that require lower neutron flux. This was made possible by establishing a temporary by pass connection across the decay tank using local technology. The other incident was the contamination of the Dry Central Thimble (DCT) that took ...
Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I-radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fluid than in simultaneously obtained serum. Many patients with gout or various other rheumatic diseases also had detectable anticollagen antibodies. With a few notable exceptions, the majority of the reactivity detected in all patient groups was directed against covalent structural determinants present on all of the denatured collagens, suggesting a secondary reaction to tissue injury.
Effect of globular structure parameters - size of primary #alpha#-phase particles (bsub(I)), thickness and amount of plates of secondary #alpha#-phase (bsub(II), #gamma#sub(II#alpha# )) - on a complex of mechanical properties (#sigma#sub(#beta#), S, phi, asub(H), asub(T), Ksub(Q), #sigma#sub(-1), #sigma#_1_0_0"4"5"0, #sigma#sub(0.2/100)) of VT3-1 (#alpha#+#beta#)-titanium alloy is studied. The dependences obtained allow one to determine globular structure parameters, providing necessary mechanical properties. In combination with data on the effect of thermal treatment conditions on structure parameters, results obtained in the paper may be used for structure control to increase a level of required characteristics.
The stability of a solid ice cover subjected to rapidly varying water levels and discharge was investigated. The support from the bank limits the stress in the ice cover and consequently bank contact must be maintained to ensure ice cover stability. An analysis was required of the stability of ice hinges, a flexible connection between a solid ice cover and the riverbank. Phase II and phase III of the research involved a field study of the Peace River, investigating the evolution of ice hinges with water level variation, from initial ice cover cracking parallel to the banks, to a fully developed hinge. A test program of midwinter discharge variations was undertaken to gather specific data and measurements of ice hinge link length, ice thickness, hinge joint behavior, riverbank geometry, and response of ice hinging to water level variation. This volume of appendices to the study presents detailed ...
Neuron differentiation is a complex process involving various cell-cell interactions, and multiple signaling pathways. We showed previously that CD40 is expressed and functional on mouse and human neurons. In neurons, ligation of CD40 protects against serum withdrawal-induced injury and plays a role in survival and differentiation. CD40 deficient mice display neuron dysfunction, aberrant neuron morphologic changes, and associated gross brain abnormalities. Previous studies by Tone and colleagues suggested that five isoforms of CD40 exist with two predominant isoforms expressed in humans: signal-transducible CD40 type I and a C-terminal truncated, non-signal-transducible CD40 type II. We hypothesized that differential expression of CD40 isoform type I and type II in neurons may modulate neuron differentiation. Results show that adult wild-type, and CD40"-"/"- deficient mice predominantly express CD40 type I and II isoforms. ...
The full text follows. A thermal neutron imaging facility (TNIF) capable of real time neutron radiography and computed tomography was developed for the University of Texas TRIGA Mark II (UT-TRIGA) reactor from 1994-1998. The facility was developed with a through reactor beam port capable of producing a 5.2 x 10{sup 6} n/cm{sup 2}/s thermal neutron flux with a gamma dose rate of less than 1 mR/s after collimation. The original TNIF included the UT-TRIGA reactor, neutron collimation array, sample positioning system, neutron image intensifier tube, video camera, computerized image acquisition system, and a radiation shield. A 0.7 mm slit in cadmium was easily detectable using neutron radiography, and 1.4 mm diameter holes bored in an aluminum block were easily resolved using computed neutron tomography. Precise lower limits of the system resolution have hot been determined. The TNIF is currently being revamped to begin work with the ...
A few metal complexes of isatin-isonicotinoylhydrazone with Ni(II), Cr(III), Co(II), Cu(II), Zn(II) and Cd(II) have been prepared and characterized on the basis of elemental analyses, infrared and electronic spectra as well as "1H NMR spectra, conductivity and magnetic measurements. In view of the results obtained, it has been found that two molecules of isatin-isonicotinoylhydrazone are chelated to the central metal ion as bis-uninegative ONO tridentate ligand forming non-electrolytic octahedral metal complexes. (author)
Geometry optimizations of the quinoline-based platinum (II) complexes (1-R, 2-R) and their related calculations on excited state energies, electronic absorption spectra and orbital populations have been carried out by the hybrid density functional theory (DFT) and its time-dependent approach (TD-DFT). The solvent effects on excitation energies are taken into account using the conductor-like polarizable continuum model (C-PCM). The red-shifted level of absorption bands, energy gaps between the singlet ground state (S1) and the first triplet excited state (T1) for each examined complex have been elaborated thoroughly as well. We find that the quinoline-8-thoil (ligand 2) induces much more significant red-shifted level than 8-hydroxyquinoline (ligand 1), and singlet-triplet splitting energy g...
The Fast Flux Test Facility (FFTF) is a 400-MWt, sodium-cooled reactor located on the Hanford Site near Richland, Washington, USA. The FFTF is owned by the U.S. Department of Energy and is operated by the Westinghouse Hanford Company. The FFTF was designed to test fuels and materials for use in liquid metal reactors. Since initial operation in 1982, anticipated breaches of experimental fuel pins have released fission products, including cesium, into the primary sodium. Because of its high volatility, cesium vaporizes into the cover gas space, where it condenses on components and equipment and is transported into the cover gas outlet. Because of the long half-life of "1"3"7Cs, these deposits result in long-term, local radiation levels that make contact maintenance difficult. Thus, a cesium trap was installed in FFTF to reduce the cesium level in the sodium. The trap could also permit a Run Beyond Cladding Breach (RBCB) program without ...
In this paper, we investigate the dynamic behaviors of a Holling II two-prey one-predator system with impulsive effect concerning biological control and chemical control strategies-periodic releasing natural enemies and spraying pesticide (or harvesting pests) at fixed time. By using the Floquet theory of linear periodic impulsive equation and small-amplitude perturbation we show that there exists a globally asymptotically stable two-prey eradication periodic solution when the impulsive period is less than some critical value. Further, we prove that the system is permanent if the impulsive period is larger than some critical value, and meanwhile the conditions for the extinction of one of the two prey and permanence of the remaining two species are given. Finally, numerical simulation shows that there exists a stable positive periodic solution with a maximum value no larger than a given level. Thus, we can use the stability of the positive ...
The BEATRIX-II irradiation experiment is an in-situ tritium release experiment being carried out in the Fast Flux Test Facility (FFTF) reactor to evaluate the tritium release characteristics of fusion solid breeder materials. A sophisticated tritium gas handling system has been developed to continuously monitor the tritium recovery from the specimens and facilitate tritium removal from the experiment's sweep gas flow stream. The in-situ recovery experiment accommodates two different in-reactor specimen canisters with individual gas streams and temperature monitoring/control. Ionization chambers have been specifically designed to respond to the rapid changes in the tritium release rate at the anticipated tritium concentrations. Two ceramic electrolysis cells have proved effective in reducing the moisture in the gas streams to hydrogen/tritium. A tritium getter system, capable of reducing the tritium level by a factor greater than 4000, ...
Summary Purpose BMS-275183 is an oral C-4 methyl carbonate analogue of paclitaxel that has the same mechanism of action, stabilization of tubulin polymerization. The present study was designed to: (i) assess the safety and tolerability of BMS-275183, and (ii) determine a suitable Phase II dose of BMS-275183 when given on a continuous daily schedule to patients with advanced solid tumor(s). Methods This was a multi-institutional, open-label, Phase I, single-arm dose escalation study in which cohorts of eligible patients with advanced malignancies were treated with BMS-275183 orally on a continuous daily schedule. The starting dose level was 6?mg/m2/day administered once daily. Cohorts of 3 patients were treated at each dose level provided no dose-limiting toxicities (DLTs) were observed. Ea...
The objective of the current research was to examine the association of herd level disease incidence with the return over feed (ROF) (milk income minus feed cost) herd profit index offered through Canwest...Full Text Available
Microbes in nature frequently function as members of complex multitaxon communities, but the structural organization of these communities at the micrometer level is poorly understood because of limitations...Full Text Available
Commercial feed rations containing sulfamethazine at the level of 110 ppm were fed for a period of 65 days to market pigs in a study simulating normal farm practices. The levels of sulfamethazine at...Full Text Available
The development of central neuropathic pain varies among patients with spinal cord injury (SCI). The factors contributing to the development and perpetuation of segmental pain (at-level allodynia)...Full Text Available
Some of most used indicators in marine ecology are nucleic acid-derived indices. They can be divided by target levels in three groups: 1) at the organism level as ecophysiologic indicators, indicators...Full Text Available
Cardiovascular modelling has been a major research subject for the last decades. Different cardiac models have been developed at a cellular level as well as at the whole organ level. Most of...Full Text Available
Oxidative stress occurs when the level of prooxidants exceeds the level of antioxidants in cells resulting in oxidation of cellular components and consequent loss of cellular function. Oxidative...Full Text Available
1. The mechanical power spent to accelerate the limbs relative to the trunk in level walking and running, Ẇint, has been measured at various `constant' speeds (3-33...Full Text Available
Sphingomyelin (SM) is an abundant phospholipid in cell membranes and in lipoproteins. In human plasma, SM is mainly found in atherogenic lipoproteins; therefore, higher levels of SM may promote atherogenesis....Full Text Available
PurposePrevious studies suggest that some common medications alter prostate-specific antigen (PSA) levels. It remains unclear whether these reported medication effects are due to...Full Text Available
The principal cause of primary non-function in orthotopic liver transplantation is thought to be preservation injury to the microvasculature. We, therefore, evaluated if effluent levels of hyaluronate,...Full Text Available
The changes in conjugated indole-3-acetic acid (IAA) levels compared to the levels of free IAA have been analyzed during the development of bean (Phaseolus vulgaris L.) seed using quantitative...Full Text Available
ObjectiveTo examine the role of first trimester bacterial vaginosis (BV) and level of BV-associated microorganisms diagnosed using the Nugent’s Gram stain...Full Text Available
ObjectivesTo assess Croatian community pharmacists' patient care competencies using the General Level Framework (GLF).MethodsThe competencies of...Full Text Available
The aromas of fruits, vegetables, and flowers are mixtures of volatile metabolites, often present in parts per billion levels or less. We show here that tomato (Lycopersicon esculentum...Full Text Available
Various physico-chemical tissue optical clearing (TOC) methods have been suggested to maximize photon density in tissue. In order to enhance photon density, a compression-controlled low-level...Full Text Available
ObjectivesThe objectives of this study were to describe the levels of daily spiritual experiences in community-dwelling older adults, to compare levels of spiritual...Full Text Available
BackgroundManagement of nightlife in UK cities focuses on creating safe places for individuals to drink. Little is known about intoxication levels as measuring total alcohol consumption...Full Text Available
ObjectiveDisc herniations at the L1-L2 and L2-L3 levels are different from those at lower levels of the lumbar spine with regard to clinical characteristics and surgical outcome....Full Text Available
Ligature-induced periodontitis was monitored for 6 months in eight Macaca mulatta monkeys to examine clinical status, radiographic bone level, and crevicular fluid (CF) levels of prostaglandin E2 (PGE2),...Full Text Available
The level of total extracellular neuraminidase produced by 74 clinical isolates of group B streptococci isolated from diseased or asymptomatically colonized infants was assayed. Extracellular neuraminidase...Full Text Available
Six patient assessment systems that have explicit decision rules for replicating team judgments on level of care patient placement were selected for analysis. The six were selected because of their...Full Text Available
Assessment of the regulation of plant metabolism by the calcium ion requires a knowledge of its intracellular levels and dynamics. Technical problems have prevented direct measurement of the concentration...Full Text Available
The model of `ecological forestry' has evolved as a part of the development of the concept of ecosystem management. `Ecological forestry' emphasises that manipulation of a forest ecosystem should consider, and as far as practicable work within the limits of, natural disturbance patterns prior to extensive human alteration of the landscape. This paper evaluates the extent to which forest management practices in jarrah (Eucalyptus marginata) and karri (Eucalyptus diversicolor) forests of south-western Australia align with this view of the characteristics and appropriate silviculture of `ecological forestry'. Characteristics and appropriate silviculture of `ecological forestry' are evaluated in relation to (i) the stand level decisions of stand structure and harvest timing and (ii) the landsc...
The possible role of space-like objects in elementary particle physics (and in quantum mechanics) is reviewed and discussed, mainly by exploiting the explicit consequences of the peculiar relativistic mechanics of Tachyons. Particular attention is paid: (i) to tachyons as the possible carriers of interactions; (ii) to the possibility of ''vacuum decays'' at the classical level; (iii) to a Lorentz-invariant bootstrap model; (iv) to the apparent shape of the tachyonic elementary particles and its possible connection with the de Broglie wave-particle dualism. (author).
This report provides a summary of theoretical and experimental studies of actinide spectra in condensed phases. Much of the work was accomplished at Argonne National Laboratory, but references to related investigations by others are included. Spectroscopic studies of the trivlent actinides are emphasized, as is the use of energy level parameters, evaluated from experimental data, to investigate systematic trends in electronic structure and other properties. Some reference is made to correlations with atomic spectra, as well as with spectra of the (II), (IV), and higher valence states. 207 refs., 39 figs., 38 tabs.
Eight years ago, corrosion and tube denting seriously threatened the reliability and design life of steam generators, especially for closed loop arrangements in pressurized water reactors (PWRs). Concentrated research by the Steam Generator Owners Group (SGOG) diagnosed the causes and produced effective solutions, notably guidelines for water chemistry control in the secondary loop. The guidelines recommend specific levels of water impurities and remedial actions to prevent cooling-water leaks in the condenser, prevent air leaks, limit corrosion product buildup, and remove some impurities while neutralizing others. Continued research in SGOB-II is investigating intergranular corrosion and stress corrosion cracking. 3 figures.
Eight years ago, corrosion and tube denting seriously threatened the reliability and design life of steam generators, especially for closed loop arrangements in pressurized water reactors (PWRs). Concentrated research by the Steam Generator Owners Group (SGOG) diagnosed the causes and produced effective solutions, notably guidelines for water chemistry control in the secondary loop. The guidelines recommend specific levels of water impurities and remedial actions to prevent cooling-water leaks in the condenser, prevent air leaks, limit corrosion product buildup, and remove some impurities while neutralizing others. Continued research in SGOB-II is investigating intergranular corrosion and stress corrosion cracking. 3 figures.
In this study, the state-of-the art for estimating LERF is considered for the regulatory risk-informed decisions. The consideration is mainly focused on (1) the relationship between Level 2 PSA and LERF evaluation methodology, (2) the standard requirements in terms of modeling preparation and the acceptance criteria based on the application capability II of ASME PRA standard, and (3) some pending issues for developing and proposing a simplified LERF model. This study is preliminarily presented and will be updated for establishing detailed evaluation scheme of extended MPAS (multi-purpose probabilistic analysis of safety) model and preparing the technical basis.
Regular physical activity (PA) decreases the risk of several chronic diseases including some cancers, type II diabetes, obesity, and cardiovascular disease; however, the majority of US adults are not meeting the recommended levels to experience these benefits. To address this public health concern, the underlying mechanisms for behavior change need to be understood, translated and disseminated into appropriately tailored interventions. The Transtheoretical Model (TTM) provides a framework for both the conceptualization and the measurement of behavior change, as well as facilitating promotion strategies that are individualized and easily adapted. The purpose of this manuscript is to present the constructs of the TTM as they relate to PA behavior change. We begin with a brief synopsis of rec...
Radioimmunochemical assay was used to study the hypophyseal and peripheral hormones activity in 60 patients with chronic alcoholism, stage II. A correlation has been established between the patient's age and prolactin and FSH concentrations, as well as between the duration of the recent hard drinking and the concentrations of prolactin, testosterone, FSH and interstitial cell stimulating hormone. It has been shown that the manifestation of the alcoholic abstinent syndrome depended on the prolactin concentration. The test sensitivity estimated by the prolactin level rise and the testosterone level reduction reached 92.3%. The specificity of the changes detected comprised 25%. A conclusion has been made that the disorders noted in the patients with chronic alcoholic intoxication can be used as an objective test in the alcoholism diagnosis. PMID:3936321
We provide an efficient computational approach to solve the mixed integer programming (MIP) model developed by Tarim and Kingsman [8] for solving a stochastic lot-sizing problem with service level constraints under the static-dynamic uncertainty strategy. The effectiveness of the proposed method hinges on three novelties: (i) the proposed relaxation is computationally efficient and provides an optimal solution most of the time, (ii) if the relaxation produces an infeasible solution, then this solution yields a tight lower bound for the optimal cost, and (iii) it can be modified easily to obtain a feasible solution, which yields an upper bound. In case of infeasibility, the relaxation approach is implemented at each node of the search tree in a branch-and-bound procedure to efficiently sear...
Transforming growth factor (TGF)-beta isoforms (TGF-beta 1, -beta 2, and -beta 3) regulate cell growth and differentiation and have critical regulatory roles in the process of tissue repair and remodeling....Full Text Available
Succinyl(carbadethia)-coenzyme A, a synthetic substrate for adenosylcobalamin-dependent methylmalonyl-CoA mutase, has been prepared by a simplified procedure. When recombinant mutase was mixed with...Full Text Available
Eilatin-containing ruthenium complexes bind to a broad range of different nucleic acids including: calf thymus (CT) DNA, tRNAPhe, polymeric RNAs and DNAs, and viral RNAs including the HIV-1...Full Text Available
Telavancin is a bactericidal lipoglycopeptide with a multifunctional mechanism of action. We conducted a randomized, double blind, active-control phase II trial. Patients ≥18 years of age with...Full Text Available
A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H2O]Cl·3H2O...Full Text Available
The modes of action of the five major endo-(1----4)-beta-D-glucanases (I, II, III, IV and V) purified from Penicillium pinophilum cellulase were compared by h.p.l.c. analysis, with normal, 1-3H-labelled...Full Text Available
Previously it was shown that the host-range gene of the Bratislava strain of avain sarcoma virus (B77 virus) spontaneously mutates with a very high rate. The wild-type B77 virus called B77 virus-II,...Full Text Available
BackgroundMultiple lines of evidence have suggested that valproic acid (VPA) might benefit patients with spinal muscular atrophy (SMA). The SMA CARNIVAL TRIAL was a two part prospective...Full Text Available
The polysaccharide components from cultured cells of Rhizobium fredii USDA205 and Rhizobium meliloti AK631 were extracted with hot phenol-water and separated by repetitive gel filtration chromatography....Full Text Available
Pharmacological activation of group II metabotropic glutamate (mGlu2 and mGlu3) receptors inhibits reward-seeking behavior and/or rewarding efficacy induced by drugs (cocaine, nicotine) or natural...Full Text Available
An (Awassi × Merino) × Merino backcross family of 172 ewes was used to map quantitative trait loci (QTL) for different milk production traits on a framework map of 200 loci across all...Full Text Available
This randomised study aimed to compare the biochemical tolerance of three parenteral regimens administered during the first 48 hours of life. Twenty nine infants were randomised to either: (a) glucose...Full Text Available
The ntpJ gene, a cistron located at the tail end of the vacuolar-type Na+-ATPase (ntp) operon of Enterococcus hirae, encodes a transporter...Full Text Available
Seven hundred thirty-two female urogenital samples were collected for Chlamydia trachomatis testing by both the Sanofi Diagnostics Pasteur (Chaska, Minn.) Chlamydia Microplate EIA by the shortened protocol...Full Text Available
Previous studies demonstrated that perinatal exposure to polybrominated diphenyl ethers (PBDEs), a major class of brominated flame retardants, may affect thyroid hormone (TH) concentrations by inducing...Full Text Available
PurposeUsing a retrospective analysis of treatment plans submitted from multiple institutions accruing patients to the RTOG #0236 non-small cell SBRT protocol, this...Full Text Available
NADPH oxidases are major sources of superoxide (O2∸) and hydrogen peroxide (H2O2) in vascular cells. Production of these reactive oxygen species...Full Text Available
Nucleotide sequence analysis of the Escherichia coli chromosomal DNA inserted in the plasmid pLC33-5 of the Clarke and Carbon library [Clarke & Carbon (1976) Cell 9, 91-99] revealed the existence...Full Text Available
The stability of a solid ice cover subjected to rapidly varying water levels and discharge was investigated. The support from the bank limits the stress in the ice cover and consequently bank contact must be maintained to ensure ice cover stability. An analysis was required of the stability of ice hinges, a flexible connection between a solid ice cover and the riverbank. Phase II and phase III of the research involved a field study of the Peace River, investigating the evolution of ice hinges with water level variation, from initial ice cover cracking parallel to the banks, to a fully developed hinge. A test program of midwinter discharge variations was undertaken to gather specific data and measurements of ice hinge link length, ice thickness, hinge joint behavior, riverbank geometry, and response of ice hinging to water level variation. As a result of the program, concepts developed throughout the ...
This study deals with the neutronics analysis of the current core configuration of a 3MW TRIGA Mark-II research reactor at Atomic Energy Research Establishment (AERE), Savar, Dhaka, Bangladesh and validation of the results by benchmarking with the experimental, operational and available Safety Analysis Report (SAR) values. The comprehensive neutronics code system SRAC was used to develop a versatile and accurate full-core model of the TRIGA core. The model represents in detail all components of the core with literally no physical approximation. All fresh fuel and control elements as well as the vicinity of the core were precisely described. Cross-section data library generated from JENDL-3.2 were used. The validation of the model against benchmark experimental results is presented. The SRA...
Platinum(II) complexes have been investigated in the hydration of alkynes. These catalysts offer improved regioselectivity over Hg(II) counterparts. 1 fig., 2 tabs.
The pathological effects of lead on the renal, nervous, reproductive, endocrine, and immune systems have been reviewed. Emphasis is placed on reported subclinical effects due to chronic, low-level lead...Full Text Available
Contagious diseases are a threat to animal health and productivity, both nationally and at the farm level. This makes implementation of biosecurity measures to prevent their introduction and...Full Text Available
Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to significant cell-to-cell variations in mRNA and protein levels. This variation...Full Text Available
High resolution of NMR spectroscopic data of biosamples are a rich source of information on the metabolic response to physiological variation or pathological events. There are many advantages...Full Text Available
To evaluate the contribution of genetic influences on the individual variation in plateau serum salicylate levels, salicylate metabolism was studied in seven pairs of identical and six pairs of fraternal...Full Text Available
This paper focuses on the Internet as a tool for enhancing behavior and lifestyle changes to reduce the burden of cancer at a population level. The premise of this paper is that the Internet...Full Text Available
Age-associated changes within an individual are inherently complex and occur at multiple levels of organismal function. The overall decline in function of various tissues is known to play a...Full Text Available
BackgroundBisphenol A (BPA) is a high-production-volume chemical commonly used in the manufacture of polycarbonate plastic. Low-level concentrations of BPA in animals and possibly...Full Text Available
Insofar as international conferences reflect the state of development of the subject under discussion, they provide an opportunity to question, at a rather fundamental level, the direction of and progress...Full Text Available
BACKGROUND:In adults, it is well known that high levels of pain catastrophizing are related to increased pain and disability as well as to heightened anxiety and depression. However,...Full Text Available
A new technique to monitor light diffraction patterns electrically is applied to frog semitendinosus muscle fibers at various levels of stretch. The intensity of the diffraction lines, sarcomere length...Full Text Available
BackgroundChanges in levels of estradiol and progesterone that occur with the transition to reproductive senescence may influence nociception or affect.Full Text Available
Metastable and somatically heritable patterns of DNA methylation provide an important level of genomic regulation. In this article, we review methods for analyzing these genome-wide epigenetic...Full Text Available
Models can be useful at many different levels when considering complex issues such as biological control of mosquitoes. At an early stage, exploratory models are valuable in exploring the characteristics...Full Text Available
... elevated blood sugar levels, but not full-blown diabetes. What are the keys to preventing the disease? ... been well studied, in a study called The Diabetes Prevention Program, in several thousand people with this ...
Quantitative microscopy has been extensively used in biomedical research and has provided significant insights into structure and dynamics at the cell and tissue level. The entire procedure...Full Text Available
Advances in modern neuroscience require the identification of principles that connect different levels of experimental analysis, from molecular mechanisms to explanations of cellular functions,...Full Text Available
In rats, drug-induced depression of the central nervous system has been shown generally to be associated with an elevation in level of total acetylcholine in the brain. This generalization held true...Full Text Available
BackgroundPerfluoroalkyl acids (PFAAs) are found globally in wildlife and humans and are suspected to act as endocrine disruptors. There are no previous reports of PFAA levels in...Full Text Available
As adulterated and substituted Chinese medicinal materials are common in the market, therapeutic effectiveness of such materials cannot be guaranteed. Identification at species-, strain- and locality-levels,...Full Text Available
AimsThis article provides a brief review of recent cross-cultural research on personality traits at both individual and culture levels, highlighting the relevance...Full Text Available
The use of repeated expressions to establish coreference allows an investigation of the relationship between basic processes of word recognition and higher-level...Full Text Available
In several respects the dorsal thalamus of Trichosurus presents a level of organizational complexity considerably in advance of that seen in Didelphis. In particular, such features as the lamination...Full Text Available
Primates are remarkably good at recognizing objects. The level of performance of their visual system and its robustness to image degradations still surpasses the best computer vision systems despite...Full Text Available
Full text of publication follows: During calculations of SAR accidents and transients it is necessary to perform steam generator simulation. Best accuracy is 3D transient calculations presented in report. Main outcomes of work was next: 1. There was shown by analysis the applicability of code TRAC (Los-Alamos laboratory) for thermal - hydraulic calculations of horizontal steam generator PGV-1000M. Special nodalization scheme was developed for it purposes. 2. Validation and selection of thermal-hydraulic correlations for improvement of using the code at calculation PGV-1000M were performed. As result Labuntsov formula is recommended for horizontal SG. 3. Calculations of nominal mode operation of PGV-1000M for cross-verification with code STEG (Electrogorsk Research and Engineering Center EREC) during its verification were performed. Solution by TRAC was obtained for transient problem after stabilization time. 4. Development of dynamic SG model as conjugate problem ...
A vendor glass formulation study was carried out at Pacific Northwest Laboratory (PNL), supporting the Phase I and Phase II melter vendor testing activities for Westinghouse Hanford Company. This study is built upon the LLW glass optimization effort that will be described in a separate report. For Phase I vendor melter testing, six glass formulations were developed at PNL and additional were developed by Phase I vendors. All the doses were characterized in terms of viscosity and chemical durability by the 7-day Product Consistency Test. Twelve Phase II glass formulations (see Tables 3.5 and 3.6) were developed to accommodate 2.5 wt% P{sub 2}O{sub 5} and 1.0 wt% S0{sub 3} without significant processing problems. These levels of P{sub 2}O{sub 5} and SO{sub 3} are expected to be the highest possible concentrations from Hanford Site LLW streams at 25 wt% waste loading in glass. The Phase H compositions formulated were 6 to 23 ...
This report describes progress on the Advanced Coal Liquefaction project by the Gulf Research and Development Company's Merriam Laboratory during the months of January through March 1983. The liquefaction behavior of Illinois No. 6 coal beneficiated in various ways was studied in both single-stage recycle (SRC II) and short contact time (SCT) modes of operation. The distillate yield increased as the iron level in the feed slurry increased in both modes of operation. In the SCT mode, the conversion increased at greater depths of cleaning. In the SRC II mode, the distillate yield and conversion were much higher with deep cleaning and add-back of pyrite than with conventional cleaning. Pyrite addition resulted in a significant increase in short contact time conversion of subbituminous Belle Ayr coal in both high and low quality solvents. Solvent quality itself, however, had little effect on conversion. With Loveridge ...
We consider the spin-k/2 XXZ model in the antiferromagnetic regime using the free-field realization of the quantum affine algebra U_q(sl_2) of level k. We give a free-field realization of the type-II q-vertex operator, which describes creation and annihilation of physical particles in the model. By taking a trace of the type-I and type-II q-vertex operators over the irreducible highest-weight representation of U_q(sl_2), we also derive an integral formula for form factors in this model. Investigating the structure of poles, we obtain a residue formula for form factors, which is a lattice analog of the higher-spin extension of Smirnov's formula in the massive integrable quantum field theory. This result as well as the quantum deformation of the Knizhnik-Zamolodchikov equation for form factors shows a deep connection in the mathematical structure of the integrable lattice models and the massive integrable quantum field ...
In this study, adipose-derived stem cells (ASCs) were cocultured with nucleus pulposus (NP) cells using a porous membrane to investigate the effect of NP cell phenotype on ASC chondrogenic differentiation. Human NP cells were collected from 14 patients and classified into two groups (normal vs. degenerative) depending on the level of type II collagen, aggrecan (AGG), type I collagen, and bax gene expression. Human ASCs were then cocultured with each group of NP cells on porous membranes in the absence of chondrogenic supplements. After 2 weeks, real-time-polymerase chain reaction results showed that ASCs cocultured with normal NP cells had much higher type II collagen and AGG gene expression than ASCs cocultured with degenerative NP cells. The production of AGG was also observed only in th...
The report was prepared for the IPCC by Working Group II. The remit of Working Group II was to describe the environmental and socioeconomic implications of possible climate changes over the next decades caused by increasing concentrations of greenhouse gases. The scenarios used include the following features: an effective doubling of atmospheric CO{sub 2} between now and 2025-2050; a consequent increase of global mean temperature of 1.5-4.5{degree}C; an unequal global distribution of the temperature increase; a sea level rise of 0.3 to 0.5m by 2050. The impacts of possible climate change were assessed for the following: agriculture and forestry; natural terrestrial ecosystems; hydrology and water resources; human settlements including the energy, transport and industrial sectors; human health; air quality and changes in UV-B radiation; oceans and coastal zones; seasonal snow cover; ice and permafrost. Further action is ...
There is very little known about the long-term evolution of the MHC and MHC-like molecules. This is because both the theory (the evolutionary questions and models) and the practice (the animals systems, functional assays and reagents to identify and characterize these molecules) have been difficult to develop. There is no molecular evidence yet to decide whether vertebrate immune systems (and particularly the MHC molecules) are evolutionarily related to invertebrate allorecognition systems, and the functional evidence can be interpreted either way. Even among the vertebrates, there is great heterogeneity in the quality and quantity of the immune response. The functional evidence for T-lymphocyte function in jawless and cartilagenous fish is poor, while the bony fish seem to have many characteristics of a mammalian immune system. The organization and sequence of fish Ig genes also indicate that important events in the evolution of the immune system and the MHC occurred in the fish, but ...
Satellite CMB anisotropy missions and new generation of balloon-borne and ground experiments, make use of complex multi-frequency instruments at the focus of a meter class telescope. Between 70 GHz and 300 GHz, where foreground contamination is minimum, it is extremely important to reach the best trade-off between the improvement of the angular resolution and the minimization of the straylight contamination mainly due to the Galactic emission. We focus here, as a working case, on the 30 and 100 GHz channels of the Planck Low Frequency Instrument (LFI). We evaluate the GSC introduced by the most relevant Galactic foreground components for a reference set of optical configurations. We show that it is possible to improve the angular resolution of 5-7% by keeping the overall GSC below the level of few microKelvin. A comparison between the level of straylight introduced by the different Galactic components for different beam regions is presented. ...
This research report discusses the radiation hardening of a commercially available mobile robot, the REMOTEC ANDROS. This hardening effort is culminating in the availability of a megarad hardened mobile platform to access areas in nuclear facilities with extremely high levels of radiation (0.1 to 1 Mrad). These radiation levels may be encountered both during routine repair and monitoring activities and accident situations. The project has completed a phase-I U.S. Department of Energy Small Business Innovative Research contract and is now in a phase-II effort with completion scheduled in early 1995. The research involves the evaluation of the material and electrical components of an ANDROS robot to determine the anticipated radiation hardness of the current production version and evaluation of the components that must be replaced or modified to harden the system to higher radiation levels. The work being ...
Epidemiological studies have revealed that butyrate and 17?-estradiol (E2) may decrease the incidence of colorectal cancer (CRC). In peripheral tissue, E2 can be produced locally by 17?-hydroxysteroid dehydrogenase 1 (HSD17B1) estrone (E1) reduction. Using quantitative real-time polymerase chain reaction and western blotting analysis, we found that sodium butyrate significantly upregulates HSD17B1 long and short transcripts and protein levels in HT29 and SW707 CRC cells. Chromatin immunoprecipitation analysis showed that upregulation of these transcript levels correlated with an increase in binding of Polymerase II to proximal and distal promoters of HSD17B1. Moreover, we observed that upregulation of HSD17B1 protein levels was associated with increased conversion of E1 to E2 in HT29 and S...
An uncertainty decrease is an very important issue for enhancing risk-informed (RI) activities worldwide. Especially, a relatively large uncertainty in a level-2 (L2) PSA risk compared with level-1 internal PSA risk has been a bottleneck problem in the RI application to the extent of a severe accident management. According to the ASME PRA standard in which sources of an uncertainty to capture a category-II RI (= Option 2) capability are listed, an uncertainty analysis which identifies the key sources of an uncertainty and includes sensitivity studies for dominant contributors to LERF (Large Early Release Frequency) needs to be provided. To solve these problems, USNRC have developed the 'SPAR-LERF' model related to the L2 RI application and 'L2 uncertainty assessment and improvement' work is being taken as a main PSA2 topic of the SARNET (Severe Accident Research Network of Excellence) program in Europe by OECD/NEA. ...
Exhaust fine and ultra fine particle numbers, particle sizes, mass, shape, structure and density were studied from Euro II - EEV emission level heavy-duty vehicles. For total particle emission factors city buses were run on dynamic conditions simulating city bus driving. The new heavy-duty chassis dynamometer of VTT was used. Vehicles were a comprehensive sample of current city bus fleet, the type approved emission level of which was Euro II - Euro III. Also cleaner engines of Euro IV to EEV targeted emission level were included: CRT, CNG, DPF. Particle emissions of these buses were extremely low; numbers 1/100 - 1/1000 and masses 1/10 - 1/100 of those of the predominating techniques. Morphological properties of fine particle populations that represent majority of particle size distribution (Da < 500 nm) are being analyzed by image processing (Matlab) from electron ...
There is now a scientific consensus that current rates of accumulation of greenhouses gases in the atmosphere will result in significant global warming and climate change. These changes are likely to have important impacts on a wide range of human activities and the natural environment. There has now been a considerable weight of literature published on the impacts of global warming, much of it very recent. This report seeks to summarise the important results, to analyse the uncertainties and to make a preliminary analysis of the feasibility of monetarising these environmental costs. The impacts of global warming are divided into ten major categories: agriculture, forests and forestry, terrestrial ecosystems and biodiversity, hydrology and water resources, sea level rise and coastal zones, energy, infrastructure/transport/industry, human health and air quality, oceans, and cryospheric impacts. The results of major summary reports are analysed, notably the report of ...
A novel envelope-type radon monitor has been used for short-term (as little as 1 week) radon concentration measurements in a workplace environment. The commercially available LR-115 type II damage track detector was used in this study and the chemically etched sheets were spark counted. The measurements were made over a period of 1 year in a workplace consisting of three adjacent rooms situated in the lower ground level of multistorey office building in Rome, Italy. The variations of the radon concentration are from [approx] 20 to [approx] 300 Bq m[sup -3] with averages of 130,81 and 73 Bq m[sup -3] for the three different rooms resulting in annual doses of [approx] 3.8, [approx] 2.4 and [approx] 2.2 mSv, respectively. (author) 2 figs., 9 refs.
Severe accident analysis has been performed for the Wolsung nuclear power= plants in Korea to investigate severe accident phenomena of CANDU-600 reactors as a part of LevelII PSA study. The accident sequence analyzed in this paper is loss of active heat sinks (LOAH) which is caused by loss of off-site power, diesel generators, and DC power. ISAAC (Integrated Severe Accident Analysis Code) computer code developed by KAERI (Korea Atomic Energy Research Institute) was used in this analysis. This paper describes the important thermal-hydraulics and source term behaviors in the primary system and inside containment, and the failure mechanisms of calandria vessel and containment. In addition, some insights for accident management program (AMP) are also given. (Author) 5 refs., 1 tab., 12 figs.
Severe accident analysis has been performed for the Wolsung nuclear power plants in Korea to investigate severe accident phenomena of CANDU-600 reactors as a part of LevelII PSA study. The accident sequence analyzed in this paper is loss of active heat sinks (LOAH) which is caused by loss of off-site power, diesel generators, and DC power, ISAAC(Integrated Severe Accident Analysis Code) computer code developed by KAERI (Korea Atomic Energy Research Institute) was used in this analysis. This paper describes the important thermal-hydraulics and source term behaviors in the primary system and inside containment, and the failure mechanisms of calandria vessel and containment. In addition, some insights for accident management program (AMP) are also given.
The authors search Z{prime} bosons in dielectron events produced in p{bar p} collisions at {radical}s = 1.96 TeV, using a 0.45 fb{sup -1} dataset accumulated with the CDF II detector at the Fermilab Tevatron. To identify the Z{prime} {yields} e{sup +}e{sup -} signal, both the dielectron invariant mass distribution and the angular distribution of the electron pair are used. No evidence of a signal is found, and 95% confidence level lower limits are set on the Z{prime} mass for several models. Limits are also placed on the mass and gauge coupling of a generic Z{prime}, as well as on the contact interaction mass scales for different helicity structure scenarios.
The authors present the results of a search for W{prime} boson decaying to electron-neutrino pairs in p{bar p} collisions at a center-of-mass energy of 1.96 TeV, using a data sample corresponding to 205 pb{sup -1} of integrated luminosity collected by the CDF II detector at Fermilab. They observe no evidence for this decay mode and set limits on the production cross section times branching fraction, assuming the neutrinos from W{prime} boson decays to be light. If they assume the manifest left-right symmetric model, they exclude a W{prime} boson with mass less than 788 GeV/c{sup 2} at the 95% confidence level.
This is the seventh report by the Advisory Committee on Reactor Safeguards (ACRS) in response to the Congressional requirement for an annual report on the Nuclear Regulatory Commission (NRC) Reactor Safety Research Program. As previously requested by the Congress, the timing of this report has been adjusted to enable the ACRS to address the proposed budget for FY 1985 that has been submitted to the Congress by the President. Part I is a compilation of our comments and recommendations regarding the NRC Safety Research Program budget for FY 1985. It is intended to serve as an Executive Summary. Part II is divided into eight chapters, each of which represents a Decision Unit of the NRC research program. In each chapter, specific comments are included on the research involved in the Decision Unit, an assessment of priorities, and recommendations regarding new directions and levels of funding.
This is the sixth report by the Advisory Committee on Reactor Safeguards (ACRS) that has been prepared in response to the Congressional requirement for an annual report on the Nuclear Regulatory Commission (NRC) Reactor Safety Research Program. Part I is a compilation of our general comments and recommendations regarding the NRC Safety Research Program, and includes budget recommendations and an identification of matters of special importance that deserve increased emphasis. It is intended to serve as an Executive Summary. Part II is divided into ten chapters, each of which represents a Decision Unit of the NRC research program. In each chapter, specific comments are included on the research involved in the Decision Unit, an assessment of priorities, and recommendations regarding new directions and levels of funding.
Examining the relationship between biodiversity and functional stability (resistance and resilience) of activated sludge bacterial communities following disturbance is an important first step towards developing strategies for the design of robust biological wastewater treatment systems. This study investigates the relationship between functional resistance and biodiversity of dominant bacterial taxa by subjecting activated sludge samples, with different levels of biodiversity, to toxic shock loading with cupric sulfate (Cu[II]), 3,5-dichlorophenol (3,5-DCP), or 4-nitrophenol (4-NP). Respirometric batch experiments were performed to determine the functional resistance of activated sludge bacterial community to the three toxicants. Functional resistance was estimated as the 30?min IC50 or th...
Annual wormwood interference on soybean crop growth and yield may result from competition and allelopathy, which are modulated by crop management. Allelochemicals released by annual wormwood (e.g. artemisinin) may affect the crop directly or indirectly through the effect on the nitrogen fixing symbiont, Bradyrhizobium japonicum. The objectives were (i) to quantify the crop response (i.e. biomass production, nodulation and yield) to weed interference and (ii) to determinate the relative change of competition and allelopathy interferences, when a sublethal dose of herbicide is applied. Two split plot field experiments with three replications were used. The experiment involved a factorial combination of five weed-crop density (soybean/annual wormwood, plantsm^-^2) levels: D1, pure soybean, 40...
Since the 1950s a transport revolution has occurred comparable to events in the late nineteenth century when sailing ships were replaced by steam vessels. Freight rates for bulk products have decreased 65-70% due to improved maritime technology, and formerly separate markets for bulk products have been unified globally. It is suggested that the low freight rates since the early 1980s will level out in future. Price peaks caused by political and military crises like the Korean war, the Suez crisis, OPEC I and OPEC II also seem to be of diminishing importance over time. The world market has become much less sensitive to external shocks due to alternative sources of supply and alternative transport routes. Examples are given from the coal, grain and iron ore international market. 62 refs., 24 figs., 4 tabs.
The autoradiographic appearance of the gastric mucosa, 5 hours after administration of indomethacin, was investigated in 29 adult rats. Indomethacin induced superficial gastric erosions. Autoradiography demonstrated the presence of viable gastric cells (as deduced by their ability to incorporate 3H-cytidin, an RNA precursor) not only in the mucosa without erosions, but also in the mucosa underneath the superficial erosions. The results indicate that indomethacin induced gastric erosions are not the superficial expression of a necrotic process taking place in the full thickness of the gastric mucosa at a particular site. A lumen-borne mechanism appears to be responsible for the formation of erosive areas in the mucosa.
A new series of heteroleptic cyclometalated platinum(II) complexes Pt-1a-f was synthesized, employing 2-arylpyridine (or 1-arylisoquinoline) (HC{sup L}AMDAN-1) and 1,3-bis(3,4-dibutoxyphenyl)propane-1,3-dione (HO{sup L}AMDAO-1) for cyclometalation and as ancillary ligands, respectively, and photoluminescent properties were investigated. Focusing on red-shifted phosphorescence, C{sup L}AMDAN ligands containing pi-extended aromatics and electron-rich heterocycles were examined. All obtained complexes exhibited photoluminescence at ambient temperature, and the emission maxima ranged from green (lambda{sub PL}=518 nm) to far red (lambda{sub PL}=708 nm). The large Stokes shifts of more than 100 nm and sub-microsecond or microsecond emission lifetimes revealed that these complexes are phosphorescent emissive. The quantum yield of Pt-1 ranged from 0.02 to 0.59 at ambient temperature and decreased as the emission maximum was red-shifted. In comparison with the reference ...
The Safety Analysis Report for the TRUPACT-II Shipping Package [Transuranic Package Transporter-II (TRUPACT-II) SARP] set limits for gas generation rates, wattage limits, and flammable volatile organic compound (VOC) concentrations in transuranic (TRU) waste containers that would be shipped to the Waste Isolation Pilot Plant (WIPP). Based on existing headspace gas data for drums stored at the Idaho National Engineering Laboratory (INEL) and the Rocky Flats Environmental Technology Site (RFETS), over 30 percent of the contact-handled TRU waste drums contain flammable VOC concentrations greater than the limit. Additional requirements may be imposed for emplacement of waste in the WIPP facility. The conditional no-migration determination (NMD) for the test phase of the facility required that flame tests be performed if significant levels of flammable VOCs were present in TRU waste containers. This paper ...
New tetradentate N(2)O(2) donor Schiff bases and their mononuclear Co(II), Ni(II), Cu(II), and Pd(II) complexes were synthesized and characterized extensively by IR, (1)H-, (13)C-NMR, mass, ESR, conductivity measurements, elemental and thermal analysis. Specifically the magnetic and electronic spectral measurements demonstrate the octahedral structures of cobalt(II), nickel(II) complexes and square planar geometries of copper(II), palladium(II) complexes. All the ligands and complexes were screened for their in vitro antibacterial activity against two gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli, Klebsiella pneumonia). In this study, Pd(II) complexes exhibited potent antibacterial activity against B. subtilis, S. aureus whereas ...
The objective of this research project is to demonstrate sensing, communication, information and control technologies to achieve a seamless integration of multivendor distributed energy resource (DER) units at aggregation levels that meet individual user requirements for facility operations (residential, commercial, industrial, manufacturing, etc.) and further serve as resource options for electric and natural gas utilities. The fully demonstrated DER aggregation system with embodiment of communication and control technologies will lead to real-time, interactive, customer-managed service networks to achieve greater customer value. Work on this Advanced Communication and Control Project (ACCP) consists of a two-phase approach for an integrated demonstration of communication and control technologies to achieve a seamless integration of DER units to reach progressive levels of aggregated power output. Phase I involved design and proof-of-design, ...
An analysis of the energy level structure of Cr{sup 3+} ions in Cs{sub 2}NaAlF{sub 6} crystal is performed using the exchange charge model (ECM) together with the crystal field analysis/microscopic spin Hamiltonian (CFA/MSH) computer package. Utilizing the crystal structure data, our approach enables modelling of the crystal field parameters (CFPs) and thus the energy level structure for Cr{sup 3+} ions at the two crystallographically inequivalent sites in Cs{sub 2}NaAlF{sub 6}. Using the ECM initial adjustment procedure, the CFPs are calculated in the crystallographic axis system centred at the Cr{sup 3+} ion at each site. Additionally the CFPs are also calculated using the superposition model (SPM). The ECM and SPM predicted CFP values match very well. Consideration of the symmetry aspects for the so-obtained CFP datasets reveals that the latter axis system matches the symmetry-adapted axis system related directly to the six Cr-F bonds well. ...
An analysis of the energy level structure of Cr3+ ions in Cs2NaAlF6 crystal is performed using the exchange charge model (ECM) together with the crystal field analysis/microscopic spin Hamiltonian (CFA/MSH) computer package. Utilizing the crystal structure data, our approach enables modelling of the crystal field parameters (CFPs) and thus the energy level structure for Cr3+ ions at the two crystallographically inequivalent sites in Cs2NaAlF6. Using the ECM initial adjustment procedure, the CFPs are calculated in the crystallographic axis system centred at the Cr3+ ion at each site. Additionally the CFPs are also calculated using the superposition model (SPM). The ECM and SPM predicted CFP values match very well. Consideration of the symmetry aspects for the so-obtained CFP datasets reveals that the latter axis system matches the symmetry-adapted axis system related directly to the six Cr-F bonds well. Using the ECM predicted CFPs as an input ...
Early diagnosis of hepatocellular carcinoma (hepatoma) along with surgical resection is the most appropriate therapeutic modality. For this purpose, there have been many reports concerning the diagnostic value of Lipiodol-CT scan. The authors selected 45 patients with hepatoma during the period of Feb.1986 to Jan. 1988 who received a conventional CT scan, hepatic angiography and a Lipiodol-CT scan. The results were as follows: 1. There was no statistical significant between serum AFP level and mass size, morphology and amount of necrosis. 2. Tumor necrosis was observed in a single massive and multinodular type when the tumor size exceeded 5 cm. 3. Pattern II on Lipiodol-CT, homogenous accumulation of Lipiodol except for the area of inner necrosis, was most frequently demonstrated, which means that a tumor mass with hypervascularity and increased blood flow will attract Lipiodol better. 4. Lipiodol-CT was superior to conventional CT in detecting ...
The expression of three c-onc genes (c-erb, c-myc, c-myb) was investigated in five cell lines established from fibrosarcomas induced with 20-methylcholanthrene (MCA) of Japanese quails. These cell lines showed low levels of the three c-onc genes, with the exception of two cell lines that accumulated moderate (MCAQ 1-4) and large amounts (MCAQ 3-5) of c-myc RNA. Molecular cloning and restriction endonuclease analyses indicated that expression of c-myc in these two cell lines were not associated with detectable rearrangements in the c-myc locus, that the size of the c-myc transcript (2.7 kb) in MCAQ 3-5 was similar to that of the normal c-myc messenger RNAs (mRNA) and that the transcriptional activatin observed in MCAQ 3-5 was not mediated by the LTR (long terminal repeat) of a proximate ALV (avian leukosis virus) provirus. Finally, when analyzed with the restriction enzymes Msp I and Hpa II, the c-myc locus of MCAQ 3-5 and MCAQ 1-4 was found ...
The poisoning effects of various trace contaminants in the coal-derived syngas stream at ppm and sub-ppm level on the performance of Ni-YSZ/YSZ/LSM solid oxide fuel cells were studied at extended duration. The thermochemical nature of impurities such as PH{sub 3}(g) and CH{sub 3}Cl(g) in presence and absence of water steam was analyzed by a high temperature mass spectrometer. Only less than half of PH{sub 3}(g) is hydrolyzed, and CH{sub 3}Cl(g) also co-exist with HCl(g). After a certain duration of exposure, 1 ppm AsH{sub 3}(g), 0.5 ppm PH{sub 3}(g), and 2.5 ppm CH{sub 3}Cl(g) all caused some degree of degradation to the power density at 750 C. Whereas 1 ppm of H{sub 2}S(g) resulted in immediate performance loss. The mechanisms of degradation are mainly divided into two categories: surface adsorption effect (for S and Cl) and bulk reaction effect (for As and P). The controversies regarding the poisoning effect and mechanism of S are also discussed with the aid of ...
The procedure was developed to enable STUK (Radiation and Nuclear Safety Authority) to make simplified estimates on off-site consequences based on the existing results of the PSA level 2 calculations done by e.g. power utilities. Method is based on dose calculated from each nuclide group of reactor activity inventory when the same release fraction for each group is assumed. This means that a specific new result from PSA level 2 can be categorised to find out a representative PSA level 3 result for this case. In addition a user interface including the procedure was prepared. Secondly some new insights about consequences based on the releases from PSA level 2 is expected to give better understanding of risks at prevailing increased reactor power levels. In this case only some early health effects and long-term doses were estimated without full-scope PSA ...
Nuclear facilities of the Department of Energy (DOE) located at the Savannah River Site must comply with DOE orders as implemented at DOE-SR. The DOE orders cover safety criteria, design criteria, environmental protection, occupational health and safety. The program applies to DOE and contractors. In this section, the Nuclear Regulatory Commission (NRC) criteria and industry codes and standards are addressed as well as DOE orders. Specific DOE orders which add additional criteria have also been noted. A program for assessing and implementing contractor applicable DOE orders has been established. This program ensures that compliance is achieved through developing and implementing policies, programs, and procedures. The primary emphasis is placed on safe, efficient reactor restart and operation. DOE has classified orders applicable to restart as Level I, Category I while those applicable to post-restart are classified as Level I, Category ...
Although hippocampal infusions of glucose enhance memory, we have found repeatedly that septal glucose infusions impair memory when γ-aminobutyric acid (GABA) receptors are activated....Full Text Available
In vitro rooting response and indole-3-acetic acid (IAA) levels were examined in two genetically related dwarfing apple (Malus pumila Mill) rootstocks. M.26 and M.9...Full Text Available
Low-level lead exposure during early childhood has long been associated with altered neurocognitive development and diminished cognitive functions. Over nine thousand U.S. industrial facilities...Full Text Available
Altogether 99 029 men aged 40-59, employed on the Italian railroad system, were classified in three levels of physical activity at work and three levels of job responsibility and then followed up for...Full Text Available
Oestrogen has been reported to modulate tumour necrosis factor (TNF), interleukin (IL)-1 and IL-6 cytokine levels in human mononuclear cell cultures. In the present study, the effects of exogenous oestrogen...Full Text Available
The influence of exogenous indole-3-acetic acid (IAA) and indole-3-butyric acid (IBA) on the internal levels of these auxins was studied during the first 4 days of adventitious root formation in cuttings...Full Text Available
Spark ignition internal combustion engines perform satisfactorily when the fueled with biomass producer gas from a fluidized bed gasifier. Although power output is reduced compared to natural gas levels, full power recovery can be achieved with a relatively low level of supercharging. Important considerations are an adequate fuel delivery system and adquate gas cleaning. ref.
Background and purpose:Theoretically, three α1-adrenoceptor subtypes can interact at the signalling level to alter vascular contraction or at the molecular level...Full Text Available
Cu"2"+ ions are alternatively bridged by end-on and asymmetrical end-to-end (EE) azido groups in copper (II)-azido compound [#left brace#Cu(L)(N_3)_2#right brace#_n] (L=benzylamine). The electronic structure of its ferromagnetic ground state has been calculated using the self-consistent full-potential linearized augmented plane wave method based on the density functional theory. The spin populations have been found to be strongly positive on the Cu"2"+ ions, weakly positive on the terminal nitrogen atoms of the azido groups as well as on the nitrogen atoms of the benzylamine, and feeble on the central nitrogen atoms of the azido groups. Based on the spin distribution obtained from calculation, the ferromagnetic coupling through the azido groups has been analyzed as resulting from a spin delocalization from the Cu"2"+ ions toward the azido groups. But the result also indicates that the spin polarization effect may also take part in the magnetic ...
BackgroundHarbour porpoises Phocoena phocoena from the southern North Sea are known to display high levels of Zn and Hg in their tissues linked to their nutritional...Full Text Available
This tongue-in-cheek essay hopes to prompt discussion among health information management (HIM) professionals of all levels with regard to the fast-changing HIM landscape, particularly the electronic...Full Text Available
PurposeWe conducted a comparative study of Clinical Target Volume (CTV) definition of pelvic lymph nodes by multiple GU radiation oncologists looking at the levels...Full Text Available
Uridine adenosine tetraphosphate (Up4A) has been recently reported as an endothelium-derived vasoconstrictor and plasma levels of this dinucleotide are increased in juvenile hypertensive...Full Text Available
BackgroundProlylcarboxypeptidase (Prcp) gene, along with altered PRCP and kallikrein levels, have been implicated in inflammation pathogenesis. PRCP regulates angiotensin...Full Text Available
A method for the study of conjugated polyelectrolyte (CPE) photophysics in solution at the single-molecule level is described. Extended observation times of single polymer molecules are enabled by the...Full Text Available
We previously reported that acetaminophen (APAP) caused apoptosis of C6 glioma cells. Therefore, we hypothesized that the level of p53, which usually stimulates apoptosis, might be increased...Full Text Available
In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in...Full Text Available
Background:Tobacco smoking is the most important risk factor for chronic obstructive pulmonary disease (COPD) development. Inhaled cigarette smoke can induce tumor necrosis factor-α...Full Text Available
The genes which encode glycosomal glyceraldehyde-phosphate dehydrogenase (gGAPDH) of Trypanosoma cruzi are arranged as a tandemly repeated pair on a single chromosome and are identical at the level...Full Text Available
OBJECTIVE: The objective was to define and characterize the costs associated with trauma care at a level I trauma center. Once the costs were identified, attending physician-led teams were designed...Full Text Available
Iron overload is common in patients undergoing allogeneic hematopoietic cell transplantation (HCT), but the mechanisms leading to overload are unknown. Here, we determined iron levels and the expression...Full Text Available
The purine adenosine appears to be involved in regulation of coronary vascular tone. Little is known concerning the levels and distribution of adenosine and related purines in the extracellular fluid...Full Text Available
Demographic and health surveillance (DS) systems monitor and document individual and group-level processes in well-defined populations over long periods of time. The resulting data are complex...Full Text Available
FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluorodeoxyuridine (FdU) that affect intracellular thymidylate levels. FRAXA coincides with a >200...Full Text Available
Storage proteins are deposited into protein storage vacuoles (PSVs) during plant seed development and maturation and stably accumulate to high levels; subsequently, during germination the storage...Full Text Available
Domestic, low-level exposure to radon gas is considered a major environmental lung-cancer hazard involving DNA damage to bronchial cells by α particles from radon progeny. At domestic exposure...Full Text Available
PurposeTo date there remains no effective therapy for metastatic melanoma and at the molecular level disease progression remains poorly understood. Recent work by...Full Text Available
Samples of longissimus and multifidi muscles at the thoracic and lumbar levels of the spine were examined histochemically on autopsy specimens from 21 adult male subjects (aged 22 to 46 years) and on...Full Text Available
Few studies have examined the association between sex hormone serum levels, erectile function, and sex drive. Using data from the Olmsted County Study of Urinary Symptoms and Health Status among...Full Text Available
Many of the gene products that participate in nitrogen metabolism are sensitive to nitrogen catabolite repression (NCR), i.e., their expression is decreased to low levels when readily used nitrogen...Full Text Available
Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between...Full Text Available
Skeletal muscle uses calcium as a second messenger to respond and adapt to environmental stimuli. Elevations in intracellular calcium levels activate calcineurin, a serine/threonine phosphatase, resulting...Full Text Available
Poplar (Populus tremula × alba) lignins with exceedingly high syringyl monomer levels are produced by overexpression of the ferulate 5-hydroxylase (F5H) gene...Full Text Available
PurposeDutasteride and finasteride are 5α-reductase inhibitors that dramatically decrease serum levels of dihydrotestosterone. Because androgens...Full Text Available
BackgroundClinical experience with the continuous glucose monitoring systems (CGMS) is limited in Korea. The objective of this study is to evaluate the accuracy of the CGMS and the...Full Text Available
Study DesignThis is a retrospective study that was done according to clinical and radiological evaluation.PurposeWe analyzed the clinical and radiological...Full Text Available
BackgroundCharacterizing infectious disease burden in Africa is important for prioritizing and targeting limited resources for curative and preventive services and monitoring the...Full Text Available
Previous work has provided evidence that plants may require boron to maintain adequate levels of pyrimidine nucleotides, suggesting that the state of boron deficiency may actually be one of pyrimidine...Full Text Available
During the symbiotic interaction between Medicago truncatula and the arbuscular mycorrhizal (AM) fungus Glomus intraradices, an endogenous increase in jasmonic acid...Full Text Available
BackgroundThe molecular mechanisms of variations in individual longevity are not well understood, even though longevity can be increased substantially by means of diverse experimental...Full Text Available
Supplementation of various cultures of white rot fungi with tryptophan was found to have a large stimulatory effect on lignin peroxidase activity levels. This enhancement was greater than that observed...Full Text Available
Goals of workThe goal of this study was to evaluate, at a population level, the association between specialized palliative care services (SPCS) and short- and long-term caregiver...Full Text Available
Sexually-selected communication signals can be used by competing males to settle contests without incurring the costs of fighting. Steroid regulation of these signals can render them as reliable...Full Text Available
Biomass fuel burning leads to high levels of suspended particulate matter and hazardous chemicals in the indoor environment in countries where it is in common use, contributing significantly to indoor...Full Text Available
BackgroundTo determine male outpatient attenders' sexual behaviours, expectations and experience of talking about their sexuality and sexual health needs with a doctor.MethodsA...Full Text Available
Although genetically identical for autosomal Chrs (Chr), male and female preimplantation embryos could display sex-specific transcriptional regulation. To illustrate sex-specific differences at the...Full Text Available
Background/AimsHelicobacter pylori (H. pylori) infection appears to subvert the human iron regulatory mechanism and thus upregulates hepcidin, resulting...Full Text Available
Human epidermal growth factor receptor 2 (HER2) is one of the most important prognostic and predictive factors for breast cancer patients. Recently, serum HER2...Full Text Available
A previous report of high levels of members of the domain Archaea in Antarctic coastal waters prompted us to investigate the ecology of Antarctic planktonic prokaryotes. rRNA hybridization...Full Text Available
The intracellular bioavailability of lead (Pb) at low dosage levels in major target organs such as the kidney and brain appears to be largely determined by complexation with a group of low molecular...Full Text Available
A recent EPA-sponsored study of sediment and seafood contamination in Quincy Bay revealed elevated levels of several complex organic pollutants frequently of concern in human health assessments. A seafood...Full Text Available
BackgroundSymptomatic heterotopic ossification (HO) in multiple trauma patients may lead to follow up surgery, furthermore the long-term outcome can be restricted. Knowledge of the...Full Text Available
BackgroundThe main objective of this study was to determine the prevalence and factors associated with mental illness in Oyo State at community level using the general health questionnaire...Full Text Available
Phosphatidic acid (PA) is postulated to have both structural and signaling functions during membrane dynamics in animal cells. In this study, we show that before a critical time period during rhabdomere...Full Text Available
The levels of glucose, sugar phosphates, and adenosine phosphates were determined in primary leaves of intact bean plants during normal senescence and compared to leaves in which senescence was delayed...Full Text Available
The level of bone morphogenetic protein 2 (BMP2) profoundly influences essential cell behaviors such as proliferation, differentiation, apoptosis, and migration. The spatial and temporal pattern...Full Text Available
BackgroundEukaryotic DNA replication is regulated at the level of large chromosomal domains (0.5–5 megabases in mammals) within which replicons are activated relatively synchronously....Full Text Available
Growth hormone (GH) has an important role in the regulation of hepatic LDL receptor expression and plasma lipoprotein levels. This investigation was undertaken to evaluate if these effects of GH on...Full Text Available
Washed cell suspensions of Desulfovibrio desulfuricans subsp. aestuarii were capable of reducing nanomolar levels of selenate to selenide as well as sulfate to sulfide....Full Text Available
Although myo-inositol is included in media for the successful growth of plant tissues, the actual requirement of most tissues, including soybean (Glycine max) callus in suspension culture, for myo-inositol...Full Text Available
A barley (Hordeum vulgare L.) mutant (Az34) has been identified with low basal levels of abscisic acid (ABA) and with reduced capacity for producing ABA in response to water stress....Full Text Available
We examined the changes in the levels of indoleacetic acid (IAA), IAA esters, and a 22-kilodalton subunit auxin-binding protein (ABP1) in apical mesocotyl tissue of maize (Zea mays...Full Text Available
Gene expression is a unique way of characterizing how cells and organisms adapt to changes in the external environment. The measurements of gene expression levels upon exposure to a chemical can be...Full Text Available
ObjectivesTo describe the prospects, achievements, challenges and opportunities for implementing intermittent preventive treatment for malaria in pregnancy (IPTp) in Tanzania in...Full Text Available
Placental and placental-like alkaline phosphatase (PLAP) levels in the culture media of 87 cell lines of neoplastic and 'normal' origin were measured by a conventional immunosorbent enzymatic assay...Full Text Available
Auxin-induced pea (Pisum sativum) stem section elongation is enhanced at levels of 3 to 40 micromolar by six new classes of alkane derivatives additional to those described earlier,...Full Text Available
School buses contribute substantially to childhood air pollution exposures yet they are rarely quantified in epidemiology studies. This paper characterizes fine particulate matter (PM2.5)...Full Text Available
This program focused on practice-level service change as a means of improving patient care and developing leadership skills of 19 general practitioners (GPs) and aimed to: promote and support change...Full Text Available
1 Measuring total plasma levels of disopyramide (DP) and the main metabolite mono-N-dealkyldisopyramide (MND) in patients on maintenance therapy with DP has shown concentrations of MND comparable with...Full Text Available
Cell suspension cultures of tomato, Lycopersicon esculentum Mill. cv VFNT-Cherry, produce phytochelatins (poly[γ-glutamylcysteinyl]glycines) when exposed to cadmium. The synthesis...Full Text Available
Current drug treatments for post-menopausal osteoporosis cannot eliminate bone fractures, possibly because the mechanisms responsible for bone loss are not fully understood. Although research within...Full Text Available
Purpose:The goal of this study was to use two separate databases to evaluate the clinical outcomes and the economic impact of adherence to Level I Pathways, an evidence-based oncology...Full Text Available
Despite the health-related benefits of exercise, many people do not engage in enough activity to realize the rewards, and little is known regarding the genetic or environmental components that account...Full Text Available
Women experience a decline in estrogen and androgen levels after natural or surgically induced menopause, effects that are associated with a loss of sexual desire and bone mineral density. Studies in...Full Text Available
The latest-generation cochlear implant devices provide many deaf patients with good speech recognition in quiet listening conditions. However, speech recognition deteriorates rapidly as the level of...Full Text Available
Human skin is a local source of corticotropin-releasing hormone (CRH) and expresses CRH and CRH receptors (CRH-R) at mRNA and protein levels. Epidermal melanocytes respond to CRH by induction...Full Text Available
In this study, we investigated on a systems level how complex protein interactions underlying cell polarity in yeast determine the dynamic association of proteins with the polar cortical domain (PCD)...Full Text Available
BackgroundModeling of a complex biological process can explain the results of experimental studies and help predict its characteristics. Among such processes is transcription in...Full Text Available
Glycoprotein 60 (gp60) is a normal plasma protein (mean concentration in normal serum 34 micrograms/ml) that is present in increased levels (mean concentration 97 micrograms/ml) in the sera of patients...Full Text Available
BackgroundLake Tanganyika (LT) is the oldest of the African Rift Lakes and is one of the richest freshwater ecosystems on Earth, with high levels of faunal diversity and endemism....Full Text Available
ER niacin combined with simvastatin provides an additional option for achieving LDL-C and non-HDL-C goals for cardiovascular prevention, with greater efficacy in those with triglyceride levels >200...Full Text Available
BackgroundA key question in the risk assessment of exposures to multiple chemicals is whether mixture effects may occur when chemicals are combined at low doses which individually...Full Text Available
BackgroundGrapevine is subjected to numerous pests and diseases resulting in the use of phytochemicals in large quantities. The will to decrease the use of phytochemicals leads to...Full Text Available
BackgroundThe various tasks of visual systems, including course control, collision avoidance and the detection of small objects, require at the neuronal level the dendritic integration...Full Text Available
Acylation stimulating protein (ASP, C3adesArg) is an adipose tissue derived hormone that stimulates triglyceride (TG) synthesis. ASP stimulates lipoprotein lipase (LPL) activity by relieving feedback...Full Text Available
BackgroundRecent research highlights the promise of remotely sensed aerosol optical depth (AOD) as a proxy for ground-level particulate matter with aerodynamic diameter ≤...Full Text Available
Oryza sativa or Asian cultivated rice is one of the major cereal grass species domesticated for human food use during the Neolithic. Domestication of this species from the wild grass...Full Text Available
Hormone potency depends on receptor availability, regulated via gene expression and receptor trafficking. To ascertain how central leptin receptors are regulated, the effects of leptin challenge, high-fat...Full Text Available
Given the high prevalence of overweight and low levels of physical activity among children, a better understanding of physical activity behaviour is an important step in intervention planning. This...Full Text Available
Since a large body of data has suggested a significant role for alpha-fetoprotein (AFP) in the regulation of the immune response at a number of levels, we examined the possibility of a specific receptor...Full Text Available
Computational prediction of microRNA targets remains a challenging problem. The existing rule-based, data-driven and expression profiling approaches to target prediction are mostly approached from the...Full Text Available
ObjectiveTo investigate possible differences in operative delivery rate among low-risk women, randomised to an alongside midwifery-led unit or to standard obstetric units within...Full Text Available
BackgroundIntegration of medical care across clinicians and settings could enhance the quality of care for patients. To date, there is limited data on the levels of integration in...Full Text Available
In this study, we aimed to demonstrate whether spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal derived from resting state functional magnetic resonance imaging (fMRI) reflect...Full Text Available
The three main subspecies of the Culex pipiens complex—pipiens, fatigans and molestus—have similar “normal” levels of susceptibility to insecticides....Full Text Available
Colonization of barley (Hordeum vulgare cv Salome) roots by an arbuscular mycorrhizal fungus, Glomus intraradices Schenck & Smith, leads to elevated levels...Full Text Available
There is increasing consensus that the uterotrophic estrogenicity assay should be coupled with other morphometric or molecular end points that might enhance its sensitivity. We have previously shown...Full Text Available
The levels of in vitro protein binding of cefonicid and cefuroxime in human adult and neonatal sera were compared. Binding parameters for each drug were determined within the concentration range of...Full Text Available
The beneficial effect of improving yeast redox response by increasing thioredoxin levels has been shown. Decreased lipid and protein oxidation is reflected in an increased biomass yield. In addition,...Full Text Available
Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level. Metformin increases lifespan and prevents cancer...Full Text Available
Background and AimsSulfonylurea (SU) herbicides are used extensively in cereal–livestock farming zones as effective and cheap herbicides with useful levels of residual activity....Full Text Available
Calorie restriction (CR) induces a metabolic shift towards mitochondrial respiration; however, molecular mechanisms underlying CR remain unclear. Recent studies suggest that CR-induced mitochondrial...Full Text Available
OBJECTIVE:To evaluate the profile of osteoporosis treatment among patients hospitalized due to hip fractures at a tertiary-level university hospital. To compare the impact of hospitalization...Full Text Available
We describe here seven cases (from five kindreds) of Anderson's disease, which is characterized by diarrhea, steatorrhea, hypobetalipoproteinemia with low levels of cholesterol, triglycerides, and phospholipids,...Full Text Available
Urmia Lake has been designated as an international park by the United Nations. The lake occupies a 5700 km2 depression in northwestern Iran. Thirteen permanent rivers flow into the lake. Water level...Full Text Available
Health has long been intertwined with the foreign policies of states. In recent years, however, global health issues have risen to the highest levels of international politics and have become accepted...Full Text Available
Clindamycin concentrations in gingival crevicular fluid and in blood were determined over a 7-h period and were related to the minimal inhibitory concentrations of this agent for 340 bacterial strains...Full Text Available
Available in vitro and animal studies have shown cancer protective effects of tea polyphenols. Recent study suggests a greater protective effect of green tea intake on breast cancer...Full Text Available
γ-Aminobutyric acid (GABA)-ergic transmission is critical for normal cortical function and is likely abnormal in a variety of neuropsychiatric disorders. We tested the in...Full Text Available
Fluctuating asymmetry (FA) has been widely used as a stress-related phenotypic marker of developmental instability. However, previous studies relating FA to various stressful conditions have produced...Full Text Available
We used the idea of hierarchical control to study multi-muscle synergies during a whole-body sway task performed by a standing person. Within this view, at the lower level of the hierarchy,...Full Text Available
Background and Aim: The purpose of this study was to establish for the first time reference curves for body fat levels in a Greek pediatric population aged 7-15y.Methods:...Full Text Available
In a study in western Kenya of malaria-infected adult women who had been treated with chloroquine, we compared the level of chloroquine and its principal metabolite, desethylchloroquine, in urine,...Full Text Available
This study investigated potential risk factors for the presence of Salmonella on 89 Alberta swine-finishing farms with the use of a questionnaire. Salmonella status...Full Text Available
Workers from cotton mills were exposed to cotton dust during carding in an experimental cardroom. Cotton from different geographical locations with varying amounts of endotoxin were used. Exposure levels...Full Text Available
Silent information regulators are potent NAD+-dependent protein deacetylases, which have been shown to regulate gene silencing, muscle differentiation and DNA damage repair. Here,...Full Text Available
The nephrotoxicity of cefoxitin was studied in a rat model of impaired renal function. Two levels of renal impairment were produced: "moderate," with blood urea concentrations of 100 to 150 mg/100 ml...Full Text Available
BackgroundEpidemiologic studies associate lung cancer in non-smoking Chinese women with Chinese-style wok cooking. Our goal was to quantify carcinogen and toxicant...Full Text Available
Neurons containing the neuropeptide hypocretin (orexin) are localized only in the lateral hypothalamus from where they innervate multiple regions implicated in arousal, including the basal forebrain....Full Text Available
BACKGROUND. Diabetes can be effectively treated and monitored in general practice. Postgraduate medical education at a local level is required to support this strategic shift of medical care from hospital...Full Text Available
The purpose of the present study was to determine whether exposure to exogenous physiological concentrations of caffeine influence contractility, Ca2+ handling, and fatigue development...Full Text Available
1. Sensory fibres innervate the adrenal medulla but their function is not known. In this paper we have studied the effect of capsaicin-sensitive sensory fibres on the adrenal catecholamine (CA) response...Full Text Available
Nursing infants may be exposed to lead from breast milk, but relatively few data exist with which to evaluate and quantify this relationship. This route of exposure constitutes a potential infant hazard...Full Text Available
In virtually all organisms, life expectancy is profoundly affected by caloric intake. For example, dietary restriction (DR; a feeding regimen of fewer calories compared to the ad libitum level without...Full Text Available
BackgroundStudies conducted in developed countries using economic models show that individual- and household- level variables are important determinants of health insurance ownership....Full Text Available
BackgroundChronic wasting disease (CWD) of cervids is a prion disease distinguished by high levels of transmissibility, wherein bodily fluids and excretions are thought to play an...Full Text Available
BackgroundPhysical inactivity is related to many morbidities but the evidence of its link with depression in adolescents needs further investigation in view of the existing conflicting...Full Text Available
The causality of observed associations between air pollution and respiratory health in children is still subject to debate. If reduced air pollution exposure resulted in improved respiratory health...Full Text Available
OBJECTIVES. Worldwide declines in the duration of lactation are cause for public health concern. Higher levels of dichlorodiphenyl dichloroethene (DDE) have been associated with shorter durations of...Full Text Available
BackgroundAtrial fibrillation (AF) is the most common cardiac arrhythmia with a population prevalence of about 1%. Natriuretic peptide level is elevated in patients with AF with...Full Text Available
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an evolutionarily conserved glycolytic enzyme, is constitutively expressed in most cell types yet is induced to high levels during the development of...Full Text Available
Elemental mercury has been imbued with magical properties for millennia, and various cultures use elemental mercury in a variety of superstitious and cultural practices, raising health concerns for...Full Text Available
The pharmacokinetics of two prodrugs of zidovudine (AZT), 1,4-dihydro-1-methyl-3-[(pyridylcarbonyl)oxy] ester and isoleucinyl ester (DPAZT and IAZT, respectively), were investigated in a rabbit model...Full Text Available
BackgroundPrimary hepatocytes are the best resource for in vitro studies directed at understanding hepatic processes at the cellular and molecular levels, necessary...Full Text Available
We explored the association between groundwater radon levels and childhood cancer mortality in North Carolina. Using data from two state-wide surveys of public drinking water supplies, counties were...Full Text Available
The monoterpene fraction of the lemon-scented sweet basil (Ocimum basilicum) cv Sweet Dani consists mostly of citral (a mixture of geranial and neral), with lower levels of geraniol...Full Text Available
Characteristics relevant to cardiovascular disease, including anthropometry, arterial blood pressure, serum cholesterol levels, chest radiography and electrocardiography, were investigated in a survey...Full Text Available
AimThe goal of this study is to characterize the changes in 33 biomarkers within the gingival crevicular fluid during the 3-week induction and 4-week resolution of...Full Text Available
We study the integration of multisensory and central input at the level of an identified fly motoneuron, the ventral cervical nerve motoneuron (VCNM) cell, which controls head movements of the animal....Full Text Available
SummarySpatial control of gene expression, at the level of both transcription and translation, is critical for cellular differentiation [1-Full Text Available
Evidence suggests that patients with irritable bowel syndrome (IBS) are hyper-responsive to environmental, physical, and visceral stimuli. IBS patients also frequently report poor sleep quality....Full Text Available
BackgroundAs the first pathway-specific enzyme in carotenoid biosynthesis, phytoene synthase (PSY) is a prime regulatory target. This includes a number of biotechnological approaches...Full Text Available
BackgroundLevels of brominated flame retardants are increasing in U.S. populations, yet little data are available on body burdens of these and other persistent hormonally-active...Full Text Available
Like other halophytic chenopods, sugar beet (Beta vulgaris L.) can accumulate high betaine levels in shoots and roots. N,N,N-trimethylglycine impedes sucrose crystallization...Full Text Available
Radionuclides are distributed nonuniformly in tissue. The present work examined the impact of nonuniformities at the multicellular level on the lethal effects of 210Po. A three-dimensional...Full Text Available
Although salamanders are characteristic amphibians in Holarctic temperate habitats, in tropical regions they have diversified evolutionarily only in tropical America. An adaptive radiation centered...Full Text Available
Gene expression from bacterial artificial chromosome (BAC) clones has been demonstrated to facilitate physiologically relevant levels compared to viral and nonviral cDNA vectors. BACs are large enough...Full Text Available
BackgroundPrevious research has demonstrated that exposure to images depicting the thin female ideal has negative effects on some females' levels of body dissatisfaction. Much of...Full Text Available
BackgroundThyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead...Full Text Available
This study was performed to investigate the association between hair mineral levels and nutrient intakes, age, and BMI in female adults who visited a woman's clinic located in Seoul. Dietary intakes...Full Text Available
Numerous epidemiological studies have consistently demonstrated that individuals who eat more fruits and vegetables (which are rich in carotenoids) and who have higher serum β-carotene levels...Full Text Available
The objective of this study was to determine the level of anesthesia attained in Xenopus laevis frogs using a propofol bath administration. Thirty-three nonbreeding female Xenopus...Full Text Available
Signatures of natural selection occur throughout the human genome and can be detected at the sequence level. We have re-sequenced ABCE1, a host candidate gene essential for...Full Text Available
BackgroundThis study assessed the level of knowledge, attitudes, and practice regarding disinfection procedures among nurses in Italian hospitals.MethodsA...Full Text Available
Amino acids labelled with dimethylaminoazobenzenesulphonyl chloride can be separated by reversed-phase high-pressure liquid chromatography and detected in the visible region (436 nm). All 19 naturally...Full Text Available
Sperm competition theory predicts that males should invest prudently in ejaculates according to levels of female promiscuity. Males may therefore be sensitive to cues in their social environment associated...Full Text Available
The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to have major effects on levels of gene expression, and numerous chromatin-altering strategies—including...Full Text Available
Rapid development in genomics in recent years has allowed the simultaneous measurement of the expression levels of thousands of genes using DNA microarrays. This has offered tremendous potential...Full Text Available
Increased oxidative stress with elevated levels of reactive oxygen and nitrogen species (ROS/RNS) plays an important role in the pathophysiology of many disease states. Increased ROS/RNS can...Full Text Available
BackgroundProteins may evolve through the recruitment and modification of discrete domains, and in many cases, protein action can be dissected at the domain level. PDZ domains are...Full Text Available
Because of the instability of Factor VIII (antihaemophilic factor) in plasma in vitro, and since evidence has accumulated that the level of activity varies significantly between samples...Full Text Available
Cysticercosis is the most common parasitic infection affecting the central nervous system. Spinal neurocysticercosis (NCC) is very rare compared with intracranial NCC and requires more aggressive management...Full Text Available
The results of this research centered on the experimental studies of a single superconducting persistent current qubit, the implementation of type-II algorithms using these qubits, and the proposal for adiabatic quantum computing using these qubits. The m...
... and high-quality photospheric-phase Type II SN spectra to constrain core- collapse SN explosions, massive star evolution, and distances in the Universe ...
This document describes payload control at LLNL to ensure that all shipments of CH-TRU waste in the TRUPACT-II (Transuranic Package Transporter-II) meet the requirements of the TRUPACT-II SARP (safety report for packaging). This document also provides specific instructions for the selection of authorized payloads once individual payload containers are qualified for transport. The physical assembly of the qualified payload and operating procedures for the use of the TRUPACT-II, including loading and unloading operations, are described in HWM Procedure No. 204, based on the information in the TRUPACT-II SARP. The LLNL TRAMPAC, along with the TRUPACT-II operating procedures contained in HWM Procedure No. 204, meet the documentation needs for the use of the TRUPACT-II at LLNL. Table 14-1 provides a summary of the LLNL waste generation and ...
Biosorption using activated sludge biomass (ASB) as a potentially sustainable technology for the treatment of wastewater containing different metal ions (Cd(II), Pb(II) and Zn(II)) was investigated. ASB metal uptake clearly competed with protons consumed by microbial biomass compared with control tests with non-activated sludge biomass. Biosorption tests confirmed maximum exchange between metal ions and protons at pH 2.0-4.5. It was revealed by the study that the amount of metal ions released from the biomass increased with biomass sludge concentration. The result showed that maximum absorption of metal ions was observed for Cd(II) at pH 3.5, Pb(II) at pH 4.0, and pH 4.5 for Zn(II) ions. The maximum absorption capacities of ASB for Cd(II), Pb(II) and Zn(II) were determined to be 59.3, 68.5 and 86.5%, ...
The study area is located in the Bekaa plain of Lebanon totaling about 12753 ha. It lies between the eastern foothills of Mount Lebanon chain and expands across the Litani River towards the foothills of the eastern Anti-Lebanon Mountains. Its characteristics, i.e. natural terrain, climate and socio-economy, make it vulnerable especially due to soil pollution. This paper tries to identify the nature and level of soil pollution by heavy metals. Valley slopes represent a complex landform and lithology that contributed to the formation of different soil. Agriculture in the plain is being practiced mainly with cash, field crops and vegetables. Throughout the central part of the plain, groundwater table is abundant and relatively high (<1.0 m. locally) that multiplies the vulnerability of the soil-groundwater system. There are different sources of pollution, such as industrial (tanneries, batteries, leather manufacturing), solid and liquid wastes, and agricultural due ...
A new generation of transmit-receive single-pass probes, denoted as C6 or X probe, was field tested during the Gentilly II, 2000 steam generator tube inspection. This probe has a performance equivalent to rotating probes and can be used for tubesheet and full-length inspection at an inspection speed equivalent to that of bobbin probes. Existing C3 transmit-receive probes have been demonstrated to be effective in detecting circumferential cracks. The C5 probe can detect both circumferential and axial cracks and volumetric defects but cannot discriminate between them. The C6 probe expands on the capabilities of both probes in a single probe head. It can simultaneously detect and discriminate between circumferential and axial cracks to satisfy different plugging criteria. It has excellent coverage, good defect detectability, and improved sizing and characterization. Probe data is displayed in C-scan format so that the amount of data to be analyzed ...
We have previously shown that avian reovirus (ARV) #sigma#A and #sigma#NS proteins possess dsRNA and ssRNA binding activity and suggested that there are two epitopes on #sigma#A (I and II) and three epitopes (A, B, and C) on #sigma#NS. To further define the location of epitopes on #sigma#A and #sigma#NS proteins and to further elucidate the biological functions of these epitopes by using monoclonal antibodies (MAbs) 62, 1F9, H1E1, and 4A123 against the ARV S1133 strain, the full-length and deletion fragments of S2 and S4 genes of ARV generated by polymerase chain reaction (PCR) were cloned into pET32 expression vectors and the fusion proteins were overexpressed in Escherichia coli BL21 strain. Epitope mapping using MAbs and E. coli-expressed deletion fragments of #sigma#A and #sigma#NS of the ARV S1133 strain, synthetic peptides, and the cross reactivity of MAbs to heterologous ARV strains demonstrated that epitope II on ...
Apart from the vulnerability implied by the START II treaty, it will bear the burden of the general political opposition to the Yeltsin administration. START II will be seen as part of an overall Yeltsin-Andrei Kozyrev foreign policy that is under fire for selling out Russian national interests in Yugoslavia, the Persian Gulf, and elsewhere. This article discusses public opinion concerning START II, the cost of its implementation, and the general purpose of the treaty.
The upgraded CDF II detector has collected first data during the initial operation of the Tevatron accelerator in Run II. The simulation of the CDF electromagnetic and hadronic central and upgraded plug (forward) calorimeter is based on the Gflash calorimeter parameterization package used within the GEANT based detector simulation of the Run II CDF detector. We present the results of tuning the central and plug calorimeter response to test beam data.
The purpose of this paper is to describe the embedded computer systems approach taken at Experimental Breeder Reactor II (EBR-II) for non-safety related systems. The hardware and software structures for typical embedded systems are presented The embedded systems development process is described. Three examples are given which illustrate typical embedded computer applications in EBR-II.
A full-length complementary DNA clone encoding tryptophan decarboxylase (TDC; EC 4.1.1.28) from Catharanthus roseus (De Luca V, Marineau C, Brisson N [1989] Proc Natl Acad Sci USA 86:...Full Text Available
This study presents a full cost approach to determine the levelized cost of energy (LCOE) of 14 electricity generation technologies. It encompasses costs incurred at all stages of the fuel cycle, including those that are traditionally omitted from economic evaluations of generation technologies. Incorporating these 'externalities' increases the likelihood of developing the most economical and sustainable power resource from a societal perspective. The following externalities are included in this analysis: damage from air pollution, energy security, transmission and distribution costs, and other environmental impacts. Incorporating externalities has a large impact on the LCOE and the relative attractiveness of electricity generation options. Results indicate that clean and efficient generation technologies are the most attractive when all options are examined using a full cost, ...
Carbalkoxylation of vinyl electrophiles was investigated using platinum complexes. This reaction occurs in two steps: (a) carbonyl insertion of {sigma}-vinyl Pt(II) halides and (b) alcoholysis of vinylic acyl Pt(II) complexes. Alcoholysis of vinylic acyl Pt(II) triflate complexes is investigated kinetically. Vinylic acyl Pt(II) complexes were isolated and characterized. 51 refs., 5 figs., 6 tabs.
Some important thermal hydraulic parameters of the 3 MW TRIGA MARK-II research reactor operating under transient condition were investigated using two computer codes PULTRI and TEMPUL. Major transient parameters, such as, peak power and prompt energy released after pulse, maximum fuel and coolant temperature, surface heat flux, time and radial distribution of temperature within fuel element after pulse, fuel, fuel-cladding gap width variation, etc. were computer and compared with the experimental and operational values as reported in the safety Analysis Report (SAR). It was observed that pulsing of the reactor inserting an excess reactivity of $2.00 shoots the reactor power level to 854.353 MW compared to an experimental value of 852 MW; the maximum fuel temperature corresponding to this peak power was found to be 846.76"o C which is much less than the limiting maximum value of fuel temperature of 1150"0 C as reported in SAR. During a pulse if ...
Objective: To compare the therapeutic effect of unilateral biliary duct drainage with bilateral biliary duct drainage in the treatment of Bismuth-Corlette II-IV type hilar cholangiocarcinoma in order to provide rational and proper clinical options. Methods: Biliary duct drainage was performed in 80 patients with hilar cholangiocarcinoma. The patients were divided into unilateral drainage group (n = 52) and bilateral drainage group (n = 28). The clinical data and the therapeutic results of the two groups were retrospectively analyzed and compared. Results The two groups were quite comparable in the patient's age, sex, clinical type, drainage way, preoperative total and direct bilirubin level, white blood cell, total protein and albumin, etc. After the treatment, the mean reduction value of the total bilirubin and direct bilirubin was 82.73 #mu#mol/L and 31.71#mu#mol/L respectively in unilateral drainage group, and was 80.28 #mu#mol/L and ...
To examine whether the neuroendocrine hormone norepinephrine may influence the production of the Shiga-like toxins (SLTs), several Escherichia coli O157:H7 clinical isolates were grown in the presence or absence of norepinephrine. An in vitro culture system consisting of low (<1500 colony-forming units/ml) initial concentrations of inocula into a serum-based medium was used to more closely approximate in vivo conditions. The growth of all isolates was increased several logs in the presence of norepinephrine, as compared with the growth in controls, during a 24-hour growth period. Controls included additional dextrose as well as the use of the norepinephrine metabolite normetanephrine, which contains one more methyl group than norepinephrine and hence would serve as a better energy source for growth if the effect were solely nutritionally mediated. During the 24 hours of growth, the production of cell-associated SLT-I on a protein-equivalent basis was shown to be increased over ...
Early in the Cold War, the United States adopted a policy of ''extended nuclear deterrence'' to protect its allies by threatening a nuclear strike against any state that attacks these allies. This threat can (in principle) be used to try to deter an enemy attack using conventional weapons or one using nuclear, chemical, or biological weapons. The credibility of a nuclear threat has long been subject to debate and is dependent on many complex geopolitical factors, not the least of which is the military capabilities of the opposing sides. The ending of the Cold War has led to a significant decrease in the number of strategic nuclear weapons deployed by the United States and Russia. START II, which was recently ratified by the Russian Duma, will (if implemented) reduce the number deployed strategic nuclear weapons on each side to 3500, compared to a level of over 11,000 at the end of the Cold War in 1991. The ...
An uncertainty decrease is an very important issue for enhancing risk-informed (RI) activities worldwide. Especially, a relatively large uncertainty in a level-2 (L2) PSA risk compared with level-1 internal PSA risk has been a bottleneck problem in the RI application to the extent of a severe accident management. According to the ASME PRA standard in which sources of an uncertainty to capture a category-II RI (= Option 2) capability are listed, an uncertainty analysis which identifies the key sources of an uncertainty and includes sensitivity studies for dominant contributors to LERF (Large Early Release Frequency) needs to be provided. To solve these problems, USNRC have developed the 'SPAR-LERF' model related to the L2 RI application and 'L2 uncertainty assessment and improvement' work is being taken as a main PSA2 topic of the SARNET (Severe Accident Research Network of Excellence) ...
Recent studies indicate that [Fe]-hydrogenases and H{sub 2} metabolism are widely distributed among green algae. The enzymes are simple structured and catalyze H{sub 2} evolution with similar rates than the more complex [Fe]-hydrogenases from bacteria. Different green algal species developed diverse strategies to survive under sulfur deprivation. Chlamydomonas reinhardtii evolves large quantities of hydrogen gas in the absence of sulfur. In a sealed culture of C. reinhardtii, the photosynthetic O{sub 2} evolution rate drops below the rate of respiratory O{sub 2} consumption due to a reversible inhibition of photosystem II, thus leading to an intracellular anaerobiosis. The algal cells survive under these anaerobic conditions by switching their metabolism to a kind of photo-fermentation. Although possessing a functional [Fe]-hydrogenase gene, the cells of Scenedesmus obliquus produce no significant amounts of H{sub 2} under S-depleted conditions. Biochemical ...
The performance of a geologic repository for high-level nuclear waste will be influenced to a large degree by thermohydrologic phenomena created by the emplacement of heat-generating radioactive waste. The importance of these phenomena is manifest in that they can greatly affect the movement of moisture and the resulting transport of radionuclides from the repository. Thus, these phenomena must be well understood prior to a definitive assessment of a potential repository site. An investigation has been undertaken along three separate avenues of analysis: (i) laboratory experiments, (ii) mathematical models, and (iii) similitude analysis. A summary of accomplishments to date is as follows. (1) A review of the literature on the theory of heat and mass transfer in partially saturated porous medium. (2) A development of the governing conservation and constitutive equations. (3) A development of a dimensionless form of the governing equations. (4) A ...
We present a study of 66 barred, early-type (S0-Sb) disk galaxies, focused on the disk surface brightness profile outside the bar region and the nature of Freeman Type I and II profiles, their origins, and their possible relation to disk truncations. This paper discusses the data and their reduction, outlines our classification system, and presents $R$-band profiles and classifications for all galaxies in the sample. The profiles are derived from a variety of different sources, including the Sloan Digital Sky Survey (Data Release 5). For about half of the galaxies, we have profiles derived from more than one telescope; this allows us to check the stability and repeatability of our profile extraction and classification. The vast majority of the profiles are reliable down to levels of mu_R ~ 27 mag arcsec^-2; in exceptional cases, we can trace profiles down to mu_R > 28. We can typically follow disk profiles out to at least 1.5 times the ...
ObjectivesThe overall aim of the proposed research is explicit in the project title, i.e. the creation of a map of current vertical land movements in the UK based on an optimal combination of absolute gravity (AG) and continuous GPS (CGPS). This is consistent with specific objective (ii) of WP1.9 of the Oceans 2025 programme and is related to priority topic area 4 (application of satellite geodesy to sea level science) of the NERC Strategic Ocean Funding Initiative (SOFI). From long term geological an [continued...]DescriptionThe proposed research aims to create a map of current vertical land movements in the UK based on an optimal combination of estimates from two geodetic surveying and monitoring techniques; the measurement of absolute gravity (AG) and the use of high precision, continuous GPS (CGPS) observations. From long term geological and geophysical studies, vertical land movements in the UK are thought to be of the order of 1 to 2 ...
Interaction of the internal states of an atom with spatially dependent standing-wave cavity field can impart position information of the atom passing through it leading to subwavelength atom localization. We recently demonstrated a different regime of atom localization [Phys. Rev. A 72, 013820 (2005)], namely sub-half-wavelength localization through phase control of electromagnetically induced transparency. This regime corresponds to extreme localization of atoms within a chosen half-wavelength region of the standing-wave cavity field. Here we present further investigation of the simplified model considered earlier and show interesting features of the proposal. We show how the model can be used to simulate a variety of energy-level schemes. Furthermore, the dressed-state analysis is employed to explain the emergence and suppression of the localization peaks, and the peak positions and widths. The range of parameters for obtaining clean sub-half-wavelength ...
An experimental investigation of a humidification-dehumidification desalination (HDD) process using solar energy at the weather conditions of Suez City, Egypt, is presented. A test rig is designed and constructed to conduct this investigation under different environmental and operating conditions. The test rig consists of a solar water heater (concentrator solar collector type), solar air heater (flat plate solar collector type), humidifier tower and dehumidifier exchanger. Different variables are examined including the feed water flow rate, the air flow rate, the cooling water flow rate in the dehumidifier and the weather conditions. Comparisons between the experimental results and other published results are presented. It is found that the results of the developed mathematical model by the same authors are in good agreement with the experimental results. The tested results show that the productivity of the system is strongly affected by the saline water temperature at the inlet to ...
An experimental investigation of a humidification-dehumidification desalination (HDD) process using solar energy at the weather conditions of Suez City, Egypt, is presented. A test rig is designed and constructed to conduct this investigation under different environmental and operating conditions. The test rig consists of a solar water heater (concentrator solar collector type), solar air heater (flat plate solar collector type), humidifier tower and dehumidifier exchanger. Different variables are examined including the feed water flow rate, the air flow rate, the cooling water flow rate in the dehumidifier and the weather conditions. Comparisons between the experimental results and other published results are presented. It is found that the results of the developed mathematical model by the same authors are in good agreement with the experimental results. The tested results show that the productivity of the system is strongly affected by the saline water temperature at the inlet to ...
The authors present a search for excited and exotic muon states {mu}*, conducted using an integrated luminosity of 371 pb{sup -1} of data collected in p{bar p} collisions at {radical}s = 1.96 TeV at the Tevatron with the CDF II detector. They search for associated production of {mu}{mu}* followed by the decay {mu}* {yields} {mu}{gamma}, resulting in the {mu}{mu}{gamma} final state. They compare the data to model predictions as a function of the mass of the excited muon M{sub {mu}*}, the compositeness energy scale {Lambda}, and the gauge coupling factor f. No signal above the standard model expectation is observed in the {mu}{gamma} mass spectrum. In the contact interaction model, they exclude 107 < M{sub {mu}*} < 853 GeV/c{sup 2} for {Lambda} = M{sub {mu}*}; in the gauge-mediated model, they exclude 100 < M{sub {mu}*} < 410 GeV/c{sup 2} for f/{Lambda} = 10{sup -2} GeV{sup -1}. These 95% confidence level exclusions ...
The PuO/sub 2/ cask or SP 5320-2 and 3 cask is designed for surface shipment of americium or plutonium. The cask design was physically tested to demonstrate that it met the criteria specified in US ERDA Manual Chapter 0529, and Chapter I, Interstate Commerce Commission. The package has been assessed for transport of up to 357 grams of plutonium (403 grams PuO/sub 2/ powder) and up to 176 grams of americium (200 grams AmO/sub 2/ powder), having a maximum decay heat of 203 watts. Criticality evaluation alone would allow the shipment as Fissile Class II but the radiation level of the cask, measured at the time of shipment, may exceed 50 mrem/h at the surface and require shipment as Fissile Class III. Sample calculations address only the more restrictive of the two materials, which in most cases is /sup 238/PuO/sub 2/.
This is the eighth report by the Advisory Committee on Reactor Safeguards (ACRS) that has been prepared in response to the Congressional requirement for an annual report on the Nuclear Regulatory Commission (NRC) Reactor Safety Research Program. As previously requested by the Congress, the timing of this report has been adjusted to enable the ACRS to address the proposed budget for FY 1986 and 1987 that has been submitted to the Congress by the President. Detailed comments and recommendations are provided for the research programs and budget proposed for FY 1986. Because both the budget for FY 1987 and the research programs for that period are highly uncertain at this time, comments on these are not provided. Part I is a compilation of general comments and recommendations regarding the NRC Safety Research Program budget for FY 1986. It is intended to serve as the Executive Summary. Part II is divided into five chapters, each of which represents a Decision Unit of ...
We have used a cell-free polymerase I transcription system derived from HeLa cells to study the regulation of human rRNA synthesis. Analysis of deletion mutants spanning the start site of transcription at nucleotide +1 indicates that the control region affecting initiation of human rRNA synthesis is contained within sequences from nucleotides -158 to +18. This promoter region can be subdivided into (i) a central segment of approximately 40 base pair that is required for transcription and (ii) flanking sequences that influence the efficiency of transcription in vitro. We have examined the in vitro transcriptional activity of the human extract under various conditions that are thought to modulate rRNA synthesis in vivo. Cell-free extracts prepared from HeLa cells infected with adenovirus 2 synthesize human rRNA at levels greatly decreased relative to uninfected cell extracts. By contrast, in vitro transcription of human rRNA is stimulated 2- to ...
A new method for the preconcentration and determination of trace amounts of lead at the {mu}g/L level in natural waters has been established based on the formation of the thenoyltrifluoroacetone (TTA) complex with dibenzo-18-crown-6 (DB18C6) by means of synergistic extraction and back-extraction combined with atomic absorption spectrometry (AAS). The effect of various factors (synergism with TTA and DB18C6, shaking time, preconcentration factor, composition of the extracted species, and foreign ions etc.) on the extraction and back-extraction of lead has been investigated in detail. The lead-TTA chelate in o-dichlorobenzene forms a stable adduct with DB18C6 as Pb(TTA){sub 2} DB18C6. The stability constant ({beta}) of the adduct determined by curve fitting method was log {beta} = 4.2. The amount of lead in natural waters such as tap water (Kanazawa University) and Kakehashi river (Komatsu City) determined by the present method was found to be 0.64 {+-} 0.02 {mu}g/L ...
The fast breeder test reactor at Kalpakkam has completed nearly 25 years of operation and is now operating at 18 MWt capacity with 46 fuel subassemblies (FSA) in the core consisting of 27 Mark-I (70% PuC + 30% UC), 13 Mark-II (55% PuC + 45% UC) and 6 MOX (44% PuO_2 + 56% UO_2) and one test PFBR FSA. Post Irradiation Examination (PIE) campaigns on FSAs at different burnup levels has provided valuable information about the irradiation behavior of the carbide fuel. This paper gives a summary of the irradiation performance of the carbide fuel evaluated through some of the investigations such as neutron radiography, x-radiography, gamma scanning, fission gas analysis and ceramography. Burnup of the carbide fuel could be enhanced from the initial design burnup limit of 50 GWd/t to 165 GWd/through systematic PIE. (author)
A search for the doubly charged Higgs boson, a member of $SU(2)_L$ scalar triplet $\\Phi$ participating in the seesaw mechanism of type II, in $pp$ collisions at $\\sqrt{s}=7$~TeV is presented. The data correspond to an integrated luminosity of 36 $\\text{pb}^{-1}$ collected by the CMS experiment at the LHC. The inclusive search is performed in events with three and four isolated charged leptons of all flavours originating from the decays of pair produced triplet components $\\Phi^{++}\\Phi^{--}$ and $\\Phi^{++}\\Phi^{-}.$ With the present collected luminosity the CMS experiment is sensitive to the $\\Phi$ mass range in which the possible decays $\\Phi^{++}\\to W^{+}W^{+}$ are forbidden kinematically. No signal excess is observed and lower limits at the 95\\% confidence level are set on the $\\Phi^{++}$ mass of 156\\GeV in the $\\mu\\mu$ channel, $154\\GeV$ in e$\\mu$ channel, of $144\\GeV$ in $ee$ channel and between $116\\GeV$ and $131\\GeV$ ...
In-situ decontamination technologies were evaluated for their ability to: (1) reduce equipment contamination levels to allow either free release of the equipment or land disposal, (2) minimize residues generated by decontamination, and (3) generate residues that are compatible with existing disposal technologies. Six decontamination processes were selected. tested and compared to 4M nitric acid, a traditional decontamination agent: fluoroboric acid (HBF{sub 4}), nitric plus hydrofluoric acid, alkaline persulfate followed by citric acid plus oxalic acid, silver(II) plus sodium persulfate plus nitric acid, oxalic acid plus hydrogen peroxide plus hydrofluoric acid, and electropolishing using nitric acid electrolyte. The effectiveness of these solutions was tested using prepared 304 stainless steel couponds contaminated with uranium, plutonium, americium, or fission products. The decontamination factor for each of the solutions and tests conditions ...
In marine seismic exploration, an approximately two-mile long hydrophone cable is towed behind the ship. The commonly employed cable consists of a kerosene-filled hose enclosing hydrophones, electrical wires, and steel ropes. The kerosene provides buoyancy while the steel ropes are for structural support. For deep-water operations, the cable is pulled through the water at a depth of 20-40 feet. For shallow water, a bottom reference configuration is used and the cable is dragged. This paper presents a comparison of electroacoustic properties between a newly designed, buoyant solid cable and those of the conventional kerosene-filled hose. The emphasis is on drag cable operations. Cable maintenance is a major problem. Jacket cuts occur because of improper handling or collisions with other ships, subsea structures, and debris. Kerosene leakage causes buoyancy loss and the need for immediate replacement. Salt water intrusion causes electrical shorts. Replacement rates on drag cables are ...
To make the doubly labelled water method for determining energy expenditure more applicable in a free-living population, collection of a single daily urine or breath sample would have advantages compared to a 24-hr urine collection. Coward et al. reported the use of a single daily urine sample. In the previously described study, a single urine collection and a fasting morning breath sample were collected from four men during two 21-day periods (fall, F, spring, S) while maintaining their body wts. on controlled diets (20% calories from protein, 40% from fat, 60% from CHO [F]; 20% protein, 20% fat, 60% CHO [S]). Urine and breath samples were analyzed to determine disappearance rates of D and "1"8O for up to 21 days. Values were compared with metabolizable energy intake levels (EI), with or without corrections for estimated changes in body composition assessed by several methods. Preliminary evaluations suggest that the single daily urine sample values may ...
Objective: To review data on efficacy and safety of second-generation antipsychotics (SGAs) in children and adolescents with psychotic and bipolar spectrum disorders. Methods: Medline/PubMed/Google Scholar search for studies comparing efficacy and/or tolerability: (i) between two or more SGAs; (ii) between SGAs and placebo; and (iii) between at least one SGA and one first-generation antipsychotic (FGA). The review focused on three major side-effect clusters: 1. body weight, body mass index, and cardiometabolic parameters, 2. prolactin levels, and 3. neuromotor side effects. Results: In total, 34 studies with 2719 children and adolescents were included. Studies lasted between 3weeks and 12months, with most studies (79.4%) lasting 3months or less. Nine studies (n=788) were conducted in patie...
Anadromous salmon in the Columbia River Basin are presently far below historic level of production, due to the impacts of development in the basin. To halt the downward trend in production and ultimately increase returns, the Northwest Power Planning Council developed the Columbia River Basin Fish and Wildlife Program. The Program outlines a coordinated plan for restoring anadromous salmonid runs to the basin. The goals and objectives outlined in the Program require addressing a complex set of problems that encompass a broad range of social, political, economic and biological issues. Resolution of these problems will require the efforts of a number of federal, state, and tribal agencies that have regulatory authority over activities that either directly or indirectly affect anadromous salmonids in the basin. Resource managers have realized the need for coordination in these efforts. The Coordinated Information System is designed to share information critical to ...
The role of intracellular Ca2+ (Ca2+i) on hematopoiesis was investigated in long term bone marrow cultures using cytokines and agonists of P2 receptors. Cytokines interleukin 3 and granulocyte/macrophage colony stimulator factor promoted a modest increase in Ca2+i concentration ([Ca2+]i) with activation of phospholipase Cgamma, MEK1/2, and Ca2+/calmodulin kinase II. Involvement of protein kinase C was restricted to stimulation with interleukin 3. In addition, these cytokines promoted proliferation (20 times) and an increase in the Gr-1(-)Mac-1+ population with participation of gap junctions (GJ). Nevertheless ATP, ADP, and UTP promoted a large increase in [Ca2+]i, moderate proliferation (6 times), a reduction in the primitive Gr-1(-)Mac-1(-)c-Kit+ population, and differentiation into macrophages without participation of GJ. It is likely that Ca2+i participates as a regulator of hematopoietic signaling: moderate increases in [Ca2+]i would be related to ...
Objective: To evaluate the clinical efficacy of multiple stents placement in the management of hilar cholangiocarcinoma, especially in the complex cases of which the hepatic ducts are invaded. Methods: Forty-five consecutive patients with hilar cholangiocarcinoma were treated with percutaneous transhepatic placement of two or three self-expandable metallic endoprostheses. The cause of hilar obstructions in these patients were all cholangiocarcinoma, including Bismuth classification type II (n 12), IIIa (n 17), IIIb (n 10), and IV (n 6). Two or 3 stents were placed in the configuration of T, Y or X over the strictures. Results: Stent placement with 2 or 3 endoprostheses was successful in all patients. All patients showed significant decrease in serum bilirubin level. The mortality rate within 30 days of stent placement was 2.2% (1/45). The mean survival and stent patency times were 215.3 d (26- 516 d) and 181.5 d (26-473 d), respectively. ...
We describe the isolation and genetic characterization of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutations in the phage P22 mnt repressor gene cloned in plasmid pBR322. Mutations in the mnt repressor gene or its operator on this plasmid, pPY98, confer a tetracycline resistance phenotype, whereas the wild-type plasmid confers tetracycline sensitivity. Cells carrying pPY98 were briefly exposed to MNNG to give 20 to 40% survival and a 50- to 100-fold increase in tetracycline-resistant cells. DNA sequence analysis showed that 29 to 30 MNNG-induced mutations were GC-to-AT transitions and one was an AT-to-GC transition. About 80% of the mutations are in three hotspots. This mutation spectrum is consistent with the proposed mechanism of mutagenic action of MNNG, which involves mispairing of an alkylated base, O/sup 6/-methylguanine. The mnt gene may be a useful target for determining mutagenic specificity at the nucleotide level because (i) forward ...
1. Contest rules The European Space Agency (ESA) is launching a public competition to find the most suitable names for its four Cluster II space weather satellites. The quartet, which are currently known as flight models 5, 6, 7 and 8, are scheduled for launch from Baikonur Space Centre in Kazakhstan in June and July 2000. Professor Roger Bonnet, ESA Director of Science Programme, announced the competition for the first time to the European Delegations on the occasion of the Science Programme Committee (SPC) meeting held in Paris on 21-22 February 2000. The competition is open to people of all the ESA member states (*). Each entry should include a set of FOUR names (places, people, or things from history, mythology, or fiction, but NOT living persons). Contestants should also describe in a few sentences why their chosen names would be appropriate for the four Cluster II satellites. The winners will be those which are considered most suitable ...
Adsorptive removal of Pb(II) ions from aqueous solution onto a non-activated charcoal (CC) of oak wood origin was studied in comparison with an activated carbon of coal origin. The adsorption capacity for Pb(II) of the non-activated charcoal increased significantly with deceasing particle diameter, whereas the activated carbon (AC) exhibited approximately constant capacity for Pb(II) adsorption as a function of particle size. Adsorption to the ashes prepared from the non-activated charcoal and the activated carbon was also investigated to examine the role of mineral ash. Although the ash from the activated carbon did not show any Pb(II) adsorption, the ash from the charcoal was very effective for Pb(II) adsorption. Furthermore, Pb(II) was hardly adsorbed when the ash was removed from the non-activated charcoal by acid treatment. Based on the results, the ...
The isotherms, kinetics and thermodynamics of Cd(II), Zn(II) and Pb(II) biosorption by Penicillium simplicissimum were investigated in a batch system. The effects of pH, initial metal ions concentration, biomass dose, contact time, temperature and co-ions on the biosorption were studied. Adsorption data were well described by both the Redlich-Peterson and Langmuir model. Chemical ion-exchange was found to be an important process based on free energy value from Dubini-Radushkevich isotherm for all metal ions. The results of the kinetic studies of all metal ions at different temperature showed that the rate of adsorption followed the pseudo second-order kinetics well. The thermodynamics constants {delta}G{sup o}, {delta}H{sup o} and {delta}S{sup o} of the adsorption process showed that biosorption of Cd(II), Zn(II) and Pb(II) ions on Penicillium simplicissimum ...
The results of the thermo-hydro-mechanical (THM) study of the FEBEX bentonite performed during FEBEX II are presented. The laboratory test program continued in part with the works carried out during FEBEX I, particularly in activities related to tests aimed to the calibration of the models, the acquisition of parameters by back-analysis and the improvement of the knowledge on the behaviour of expansive clays. But the program has also included tests on new areas: investigations about the influence of the microstructure changes in bentonite, of temperature and of the solute concentration on the behaviour of clay. Besides, several tests were proposed in order to understand the unexpected behaviour observed in the mock-up test, towards the end of year 2. Temperature effects on water retention curves in confined and unconfined conditions were determined, and swelling pressure, hydraulic conductivity and swelling and consolidation strains as a function of temperature ...
An exact cosmological solution of Einstein's equations which has time-dependent rotation is presented. The t-constant sections are of Bianchi type II. The source of this geometry is a fluid which has not been thermalized. (Author).
In this article are presented main results on electric potential investigations in stellarator/torsatron TJ-II and tokamak T-10 in a comparable regimes of device operation.
New palladium(II) and platinum(II) complexes of saccharinate (sac), trans-[Pd(py)"2(sac)"2] (1), cis-[Pt(py)"2(sac)"2] (2), trans-[Pd(3-acpy)"2(sac)"2] (3) and cis-[Pt(3-acpy)"2(sac)"2] (4) (py=pyridine and 3-acpy=3-acetylpyridine) have been synthesized. Elemental analysis, UV-Vis, IR, NMR and TG/DTA characterizations have been carried out. The structures of 1-4 were determined by X-ray diffraction. The palladium(II) and platinum(II) ions are coordinated by two N-bonded sac ligands, and two nitrogen atoms of py or 3-acpy, forming a distorted square-planar geometry. The palladium(II) complexes (1 and 3) are trans isomers, while the platinum(II) complexes (2 and 4) are cis isomers. The mononuclear species in the solid state are connected by weak intermolecular C-H...O hydrogen bonds, C-H...@...
The aim of this article was to investigate the interactions of metal cations in aqueous solutions with the biomass of the freshwater macroalga Vaucheria sp. This problem is important when elaborating new applications of biosorption, e.g. the production of mineral feed additives for livestock from the biomass of algae enriched with microelement ions. Potentiometric titration was applied as a quick and cheap screening test to search for new efficient biosorbents. It revealed a variety of functional groups capable of cation exchange on the macroalgal surface, including carboxyl, phosphate, hydroxyl or amino groups. Fourier transform infrared spectroscopy on natural and chromium-loaded Vaucheria sp. confirmed that carboxyl groups played a dominant role in the biosorption. The study also showed that Ca(II), Na(I), K(I), and Mg(II) ions were released from the biomass after biosorption of Cu(II), Mn(II), ...
The biosorption of lead (II) and copper (II) ions, single component and binary systems, by dried P. putida was investigated in a batch system. The effects of initial pH, temperature, initial single and binary mixture concentrations on the biosorption kinetics and equilibrium uptake of each component, both single and binary mixtures were investigated. The bacterial biomass exhibited the highest single and binary lead (II) and copper (II) ions uptake capacity at 25 and 30 deg. C, respectively, the initial pH value of 5.5 and at the initial metal ions concentration of 100 mg dm{sup -3}. The Freundlich and Langmuir adsorption models were used for the mathematical description of the biosorption equilibrium and isotherm constants were evaluated at different temperatures. Adsorption data were well described by the Langmuir model, although they could be modeled by the Freundlich equation. The thermodynamics ...
ii) Flammability: (iii) A capacity to oxidise: (iv) Corrosiveness: (v) Toxicity (including chronic ...an explosion or fire: (d) For substances with corrosive properties: (i) To reduce the ...likelihood of any unintended corrosion:(ii) To control the adverse effects of any corrosion:
R_2PdSi_3 compounds have been found to exhibit rich magnetic phenomena arising from the interplay between RKKY interaction, crystal electric field effects and geometric frustration due to the derived hexagonal AlB_2 structure. The observed crystallographic superstructure further complicates the CEF level scheme. Inelastic neutron scattering measurements on single crystals of Tm_2PdSi_3 and Er_2PdSi_3 have been performed at the cold triple axis spectrometer PANDA in FRM-II. Both compounds order antiferromagnetically at T_N=7 K and 2.1 K respectively; Er_2PdSi_3 undergoes a second phase transition at T_2=2 K. Several low lying CEF excitations (below 10 meV) were observed. The intensity of the lowest excitation show strong directional dependence (in HK0 plane for Er_2PdSi_3 and in HHL plane for Tm_2PdSi_3), from which the details of the transitional matrix could be deduced. Measurements in magnetic fields up to 13 T show Zeeman splitting of the ...
This Executive Summary, Volume I, of the lower Flathead System Fisheries Study Final Report, was prepared to provide a study overview for persons who are not fisheries scientists. The contents provide an introduction to the study and its objectives, a short description of the study area, a discussion of the major findings and conclusions of the study, and the description of fisheries management alternatives available to managers of the lower Flathead system. Technical reports were prepared for those portions of the study dealing with the lower Flathead River and its tributaries, Volume II, and the South Bay of Flathead Lake, Volume III. The annual hydrographic regime of the Flathead system, consisting of upper rivers, lake and lower river, has been modified by the construction and operation of two major hydroelectric facilities, Hungry Horse Dam on the south fork Flathead River and Kerr Dam at the outlet of Flathead Lake. The modified hydrographic regime has ...
How should lightweight electric-powered vehicles be promoted, after the large-scale fleet test being conducted at Mendrisio (southern Switzerland) is completed in 2001, and are there reasons to put question marks behind the current approach? The demand for electric vehicles, and particularly the one in the automobile category, has remained at a persistently low level. As it proved, any appreciable improvement of this situation is almost impossible, even with substantial financial incentives. However, the unsatisfactory sales figures have little to do with the nature of the fleet test itself or with the specific conditions at Mendrisio. The problem is rather of structural nature. For (battery-operated) electric cars the main problem at present is the lack of an expanding market which could become self-supporting with only a few additional incentives. Various strategies have been evaluated. Two alternatives were considered in particular: a strategy to promote ...
For the expansion to 2.0 MTPY of the CVG Bauxilum alumina plant, the area of clarification and red mud washing was rearranged from four 2-thickener-5-washer trains to two 1-thickener-7-washer trains. As a result of this modification, the specific mud handling capacity of the existing tanks should be increased by almost 3-times. The time allowed for control actions was then significantly reduced, leading to the need of an on-line level detection system, in order to achieve a better and faster control of the operation. With this scope, it was developed and installed a new continuous mud level detector that gives the measurement of both mud and turbid zone levels in the tanks. The development of the new instrument started with an existing instrument for density measurements which was completely re-engineered in order to obtain the maximum readability in the densities founded along the full range of the ...
... Screening Adjudication Monitoring Applicants of Information Behavior II I Conducting Investigations ... Applicants of Information Behavior Conducting ...