UK PubMed Central (United Kingdom)

The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1...Full Text Available

International Nuclear Information System (INIS)

The influence of serum, IGF-1 and TGF-#beta# on the differentiation of preadipocytes was examined in primary cultures of porcine adipose tissue cells. In serum-supplemented or serum-free, IGF-1 (1 and 10 nM) had no effect on total cell number. However, IGF-1 (10nM) increased adipocyte number only in serum-supplemented (1% pig serum) cultures, whereas TGF-#beta# (15 pm) reduced the adipocyte number in the presence and absence of IGF-1. Replication of preadipocytes was analyzed with a ["3H] thymidine assay. Preadipocyte proliferation (cpm in adipocyte fraction) was increased by IGF-1 (10nM) only in cultures containing pig serum. TGF-#beta# had no effect on preadipocyte proliferation specifically, but slightly increased total ["3H] thymidine incorporation in cultures with serum. ...

UK PubMed Central (United Kingdom)

Human longevity is in part genetically determined, and the insulin/IGF-1 signal transduction (IIS) pathway has consistently been implicated. In humans, type 2 diabetes is a frequent disease that results...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundDysregulation of the insulin-like growth factor (IGF) system, a common consequence of adiposity-induced insulin resistance, may be a key underlying mechanism...Full Text Available

UK PubMed Central (United Kingdom)

TSH receptor (TSHR) plays a central role in regulating thyroid function and is targeted by IgGs in Graves’ disease (GD-IgG). Whether TSHR is involved in the pathogenesis of thyroid associated...Full Text Available

UK PubMed Central (United Kingdom)

Whether the lusitropic potential of short-term exercise in aged rats is linked to an augmentation in the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and an alteration in the...Full Text Available

UK PubMed Central (United Kingdom)

Primary cardiac angiosarcoma is a rare cardiac tumor. The initial clinical course is often asymptomatic, and metastatic disease is present in a majority of affected patients at diagnosis. We present...Full Text Available

Science.gov (United States)

TIA (Transient Ischemic Attack)

British Library Electronic Table of Contents (United Kingdom)

This manuscript reviews some of the more controversial dose-related issues in cardiac CT imaging. Discussion covers the relative merits of cardiac CT versus MR, advantages and concerns regarding gated versus nongated cardiac CT and advantages and concerns regarding the use of breast shields in girls undergoing cardiac CT imaging.

British Library Electronic Table of Contents (United Kingdom)

Current multi-scale computational models of ventricular electromechanics describe the full process of cardiac contraction on both the micro- and macro- scales including: the depolarization of cardiac cells, the release of calcium from intracellular stores, tension generation by cardiac myofilaments, and mechanical contraction of the whole heart. Such models are used to reveal basic mechanisms of cardiac contraction as well as the mechanisms of cardiac dysfunction in disease conditions. In this paper, we present a methodology to construct finite element electromechanical models of ventricular contraction with anatomically accurate ventricular geometry based on magnetic resonance and diffusion tensor magnetic resonance imaging of the heart. The electromechanical model couples detailed repres...

UK PubMed Central (United Kingdom)

A field study of 89 refrigerator repairmen was carried out to ascertain whether occupational exposure to fluorocarbons induces cardiac arrhythmia. The concentrations of fluorocarbons in the breathing...Full Text Available

Science.gov (United States)

The effect of exercise training prior to acute myocardial infarction (AMI) on left ventricular (LV) remodeling is poorly understood. This study investigated the protective effect of 3 weeks of swimming exercise training prior to AMI on cardiac morphology and function. Male Sprague-Dawley rats (n = 35) were randomly assigned to 3 groups: swimming training (n = 14, 90 min, 5 days/wk, 3 wk), sedentary (n =14), and controls (n = 7, no exercise, no MI). At the end of the training/sedentary period, rats were subjected to AMI (ExMI and SedMI) induced by surgical ligation of the left coronary artery. Thereafter, the rats remained sedentary for a 4-wk recovery period. Trans-thoracic echocardiography was performed in each group at the end of the exercise/sedentary period (pre-AMI), 24 hr after AMI, and following recovery (4 wk after AMI). No differences were observed in LV dimensions and function pre-AMI among the 3 groups; however, LV-end systolic ...

Science.gov (United States)

PMID:21864481

Science.gov (United States)

Cardiac Arrest; Coronary Disease; Cardiovascular Risk Factors

Energy Technology Data Exchange (ETDEWEB)

To study the regulation of adipose tissue lipoprotein lipase (LPL) in human adipocytes, omental adipose tissue was obtained from healthy subjects and digested in collagenase. The isolated adipocytes thus obtained were suspended in Medium 199 and cultured at 37 degrees C. Cell viability was demonstrated in adipocytes cultured for up to 72 h by constancy of cell number, cell size, trypan-blue exclusion, and specific /sup 125/I-insulin binding. In addition, chloroquine induced an increase in cell-associated /sup 125/I-insulin at 24, 48, and 72 h after preparation. Thus, isolated adipocytes retained their ability to bind, internalize, and degrade insulin. LPL was measured as activity secreted into the culture medium (CM), released from cells by heparin (HR), and extracted from cell digests. A broad range of heparin concentrations produced a prompt release of LPL from a rapidly replenishable pool of cellular activity. When cells were cultured in medium containing 10% fetal bovine serum, ...

Science.gov (United States)

Therapeutic hypothermia is a promising method for controlling intracranial pressure (ICP) in severely brain-injured patients. However, clinical data regarding the effect of brain hypothermia on overall outcome of these patients is limited. This may be because there are specific pitfalls associated with the clinical management of induced hypothermia in patients with severe traumatic brain injury (TBI). These pitfalls may be avoided by preventing specific risk factors when cooling is induced and with rewarming. However, these risk factors have not been well systematically discussed in the literature. In this paper, three categories of clinical issues regarding the management of brain hypothermia are discussed: (1) stress-induced secondary brain injury mechanisms; (2) technical aspects of intensive care unit (ICU) cooling management; and (3) rewarming rates and methods. For patients with a Glasgow Coma Scale (GCS) score of less than 8, management of stress-induced insulin-resistant ...

UK PubMed Central (United Kingdom)

How an individual’s sex and genetic background modify cardiac adaptation to increased workload is a topic of great interest. We systematically evaluated morphological and physiological...Full Text Available

UK PubMed Central (United Kingdom)

Chest compression-only (CC-only) is now incorporated in the Norwegian protocol for dispatch guided CPR (cardiopulmonary resuscitation) in cardiac arrest of presumed cardiac aetiology.We present...Full Text Available

UK PubMed Central (United Kingdom)

Cardiovascular modelling has been a major research subject for the last decades. Different cardiac models have been developed at a cellular level as well as at the whole organ level. Most of...Full Text Available

UK PubMed Central (United Kingdom)

Tumor embolism occurs in 30 to 50% of all cases of cardiac myxoma, but the causes are still uncertain. Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade the extracellular matrix...Full Text Available

UK PubMed Central (United Kingdom)

Background:The cardiac sodium–calcium exchanger (NCX1) is a key sarcolemmal protein for the maintenance of calcium homeostasis in the heart. Since heart failure...Full Text Available

UK PubMed Central (United Kingdom)

1. The effects of 1 mg/ml whole Naja nivea (Cape cobra) venom, and of three different toxins isolated from it, on spinal reflex excitability and cardiac and skeletal muscle activity...Full Text Available

UK PubMed Central (United Kingdom)

Myocarditis, often initiated by viral infection, may progress to autoimmune inflammatory heart disease, dilated cardiomyopathy and heart failure. Although cardiac myosin is a dominant autoantigen...Full Text Available

UK PubMed Central (United Kingdom)

ObjectiveThe objective of this study was to determine the contribution of distance to hospitals with cardiac interventional services (CIS) to county age-adjusted myocardial infarction...Full Text Available

UK PubMed Central (United Kingdom)

Physiological cardiac hypertrophy is associated with mitochondrial adaptations that are characterized by activation of PGC-1α and increased fatty acid oxidative (FAO) capacity. It is...Full Text Available

CERN Document Server

Anodic protection

British Library Electronic Table of Contents (United Kingdom)

Aim: To evaluate the usefulness of routine laboratory parameters in the decision to treat refractory cardiac arrest patients with extracorporeal life support (ECLS). Methods: Sixty-six adults with witnessed cardiac arrest of cardiac origin unrelated to poisoning or hypothermia undergoing cardiopulmonary resuscitation without return of spontaneous circulation (duration: 155min [120-180], median, [25-75%-percentiles]) were included in a prospective cohort-study. ECLS was implemented under cardiac massage, using a centrifugal pump connected to a hollow-fiber membrane-oxygenator, aiming to maintain ECLS flow >=2.5l/min and mean arterial pressure >=60mmHg. Results: Forty-seven of 66 patients died within 24h from multiorgan failure and massive capillary leak. Of 19/66 patients who survived >=24h...

Medline Plus

... stenosis. It looks from the transesophageal and the 3-D echo that most of the problem is really ... posterior leaflet, which you can see on the 3-D echo image is a major source. The anterior ...

British Library Electronic Table of Contents (United Kingdom)

Opinion statement Because a minority of patients with D-transposition of the great arteries are diagnosed in utero by ultrasound, most present after delivery with cyanosis. In the absence of apparent lung disease, cyanotic neonates suspected of having a cardiac lesion should be immediately transferred to an intensive care unit at a pediatric tertiary care center for monitoring, resuscitation, and to define the cardiac anatomy and physiology. A prostaglandin E-1 infusion is usually initiated to maintain ductal patency and promote intra-cardiac mixing. In the past, balloon atrial septostomy (BAS) was routinely performed to enlarge the atrial septal defect and improve intra-cardiac mixing while the infants awaited surgery. Recent literature has reported an increase risk of stroke in neonates ...

UK PubMed Central (United Kingdom)

Congestive heart failure (CHF) is a leading cause of morbidity and mortality. CHF is marked by atrial and ventricular enlargement and reduced cardiac contractility, as well as an association...Full Text Available

International Nuclear Information System (INIS)

Cardiac Malposition refers to any position of the heart other than a left-sided heart in a situs solitus individual. Associated cardiac malformations are so complex that even angiocardiographic and autopsy studies may not afford an accurate information. Although the terms and classifications used to describe the internal cardiac anatomy and their arterial connections in cardiac malpositions differ and tend to be confusing, common agreement exists on the need for a segmental approach to diagnosis. Authors present 18 cases of cardiac malpositions in which cardiac catheterization and angiocardiography were done at the Department of Radiology, Seoul National University Hospital between 1971 and 1979. Authors analyzed the clinical, radiographic, operative and autopsy findings with the emphasis on the angiocardiographic findings. The results are as follows: 1. Among ...

Science.gov (United States)

Leukemia; Aplastic Anemia

British Library Electronic Table of Contents (United Kingdom)

Cardiac tumours may display diverse symptoms through potential involvement of any structure of the heart. We describe a case of a highly malignant thymoma with involvement of different cardiac structures with important haemodynamic compromise. With the high sensitivity of transthoracic echocardiography for detection of intracardiac masses, computed tomography and magnetic resonance add essential structural preoperative information on the tumour and surrounding tissue as vessels, pleura, lung and mediastinum.

British Library Electronic Table of Contents (United Kingdom)

Recent literature indicates that torsion of the left ventricle (LV) is a promising predictor for response to cardiac resynchronisation therapy (CRT). Among patients with severe heart failure, 45 to 75% of patients show rigid body rotation, where the base and apex rotate in the same direction, instead of normal, opposite rotation. The occurrence of this phenomenon seems to be a good indicator for response to CRT. From this review, it can be concluded that LV torsion might be a welcome addition to current selection criteria.

CERN Document Server

Radiation protection and the management of radioactive waste in the oil and gas industry

International Science & Technology Center (ISTC)

Development of the Corrosion Protection Technology for Special Steels and Alloys

International Nuclear Information System (INIS)

Lobar emphysema is an uncommon cause of respiratory distress in infancy. Congenital heart disease is seen in about 20% of the patients with infantile (congenital) lobar emphysema. We described six infants with lobar emphysema. In three of them a congenital heart disease was demonstrated by cardiac catheterization and cineangiography; two had a tetralogy of Fallot with right aortic arch and the third infant a ventricular septal defect. The pulmonary angiography showed stretching of the arteries with very poor filling of the peripheral arteries and a characteristic smaller pulmonary vein in the affected lobe. In all the six patients the pulmonary artery pressure was normal. All the patients underwent lobectomy with good results. We feel that a preoperative cardiac catheterization and cineangiography is of value in this very sick group of infants. (orig.).

Energy Technology Data Exchange (ETDEWEB)

Certain fluorocarbons, such as difluorodichloromethane (FC 12), depress the cardiovascular system by diminution of all the transmembrane ionic conductances in cardiac tissues. Does FC 12 also inhibit active transport and thus enzymatic activity and cellular energy. We measured phosphocreatine (PC), adenosine triphosphate (ATP) and cyclic adenosine monophosphate (AMPc) in rat hearts. Rats were randomly divided into 4 groups; 2 control groups: one breathing a mixture of oxygen (21%) and nitrogen (79%) (group C) and the other breathing the same mixture but simultaneously perfused with 1 microgram/kg/min. epinephrine (groupe E-C); 2 trial groups T and E-T where nitrogen was replaced by FC 12. The maximal FC 12 concentration of 720 micrograms/ml in arterial blood produced no significant difference in the concentrations of these three metabolites compared with controls.

UK PubMed Central (United Kingdom)

The side effects of cancer therapy on normal tissues limit the success of therapy. Generation of reactive oxygen species (ROS) has been implicated for numerous chemotherapeutic agents including doxorubicin...Full Text Available

UK PubMed Central (United Kingdom)

The metal parts of cardiac valve prostheses cause reactions in the surrounding tissues of the heart. In some dogs rather abnormal reactions were found, and were attributed to corrosion of the stainless...Full Text Available

UK PubMed Central (United Kingdom)

ObjectivesWe have developed an image-guided surgery system based on invisible near-infrared (NIR) fluorescent light. Presently, the only clinically-available NIR...Full Text Available

UK PubMed Central (United Kingdom)

ObjectivesPericardial tamponade after cardiac surgery is difficult to diagnose, thereby rendering timing of rethoracotomy hard. We aimed at identifying factors predicting the outcome...Full Text Available

Science.gov (United States)

We present a case of cardiac tamponade following umbilical venous catheterization in a neonate, an uncommon, yet potentially fatal complication. Timely diagnosis by echocardiography and urgent pericardiocentesis proved lifesaving. PMID:21654008

UK PubMed Central (United Kingdom)

To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG was...Full Text Available

UK PubMed Central (United Kingdom)

The thiadiazinon derivative EMD 57033 has been found previously in cardiac muscle to increase isometric force generation without a proportional increase in fiber ATPase, thus causing a reduction in...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundAtrial fibrillation (AF) is the most common cardiac arrhythmia with a population prevalence of about 1%. Natriuretic peptide level is elevated in patients with AF with...Full Text Available

UK PubMed Central (United Kingdom)

We report a case of chylopericardium after ascending aorta and aortic valve replacement, which presented as late tamponade. We discuss the various treatment options in this rare condition which can...Full Text Available

UK PubMed Central (United Kingdom)

Catheter ablation is a first line treatment for many cardiac arrhythmias and is generally performed under x-ray fluoroscopy guidance. However, current techniques for ablating complex arrhythmias such...Full Text Available

UK PubMed Central (United Kingdom)

AimsA better understanding of the ionic mechanisms for cardiac automaticity can lead to better strategies for engineering bio-artificial pacemakers. Here, we attempted to better...Full Text Available

UK PubMed Central (United Kingdom)

A case of severe intractable angina pectoris with normal angiography is presented. Following video assisted thoracic sympathectomy the patient died of heart failure. Microvascular cardiac amyloidosis...Full Text Available

Science.gov (United States)

Recent rapid growth in mobile computing technologies enables telemedicine applications to operate on mobile devices. Our focus is on the design of an integrated electrocardiogram (ECG) beat detector on a Personal Digital Assistant (PDA) platform for the health screening process. The ECG beat detector module will be supported by the PDA version of Personal Health Information Management System (PHIMS) and Facilitated Accurate Referral Management System (FARMS) through wireless network infrastructure as a home-based mobile cardiac monitoring solution. PMID:17282192

Science.gov (United States)

... ATROPINE, HI-6 AND TOXOGONIN MIGHT OFFER THE SOLUTION FOR THE OVERALL PROTECTION AGAINST NERVE GAS POISONING HAS ...

Science.gov (United States)

... Considering these observations, it is most likely that Brucela proteins involved in protective immunity will preferentially stimulate INF-g producing T ...

International Nuclear Information System (INIS)

The proactive protection measures and the traditional passive security protection tools are complementarities each other. It also can supply the conventional network security protection system and enhance its capability of the security protection. Based upon sorts of existing network security technologies, this article analyses and summarizes the technologies, functions and the development directions of some key proactive network security protection tools. (authors)

International Nuclear Information System (INIS)

Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an excellent model for hemodynamic investigations but should be ...

British Library Electronic Table of Contents (United Kingdom)

Background When assessing the function of the cardiovascular system, cardiac output (CO) is a substantial parameter. For its determination, numerous non-invasive techniques have been proposed in the recent years including inert gas rebreathing (IGR) and impedance cardiography (ICG). The aim of our study was to evaluate whether a novel ICG algorithm (electrical velocimetry) and IGR can be used interchangeably in the clinical setting. Methods A total of 120 consecutive stable patients were included resulting in two pairs of repeated non-invasive cardiac output measurements. Results The mean CO was 5.0???1.2?l/min (range 2.6?8.6?l/min) using IGR and 4.4???1.1?l/min (1.7?7.4?l/min) using ICG, respectively. Bland?Altman analysis revealed an acceptable agreement with a mean bias of 0.6???1.2?l/m...

British Library Electronic Table of Contents (United Kingdom)

Hsp20, referred to as HspB6, is constitutively expressed in various tissues. Specifically, HspB6 is most highly expressed in different types of muscle including vascular, airway, colonic, bladder, and uterine smooth muscle; cardiac muscle; and skeletal muscle. It can be phosphorylated at Ser-16 by both cAMP- and cGMP-dependent protein kinases (PKA/PKG). Recently, Hsp20 and its phosphorylation have been implicated in multiple physiological and pathophysiological processes including smooth muscle relaxation, platelet aggregation, exercise training, myocardial infarction, atherosclerosis, insulin resistance and Alzheimer's disease. In the heart, key advances have been made in elucidating the significance of Hsp20 in contractile function and cardioprotection over the last decade. This mini-rev...

British Library Electronic Table of Contents (United Kingdom)

The aims of this study were to identify risk factors and evaluate the association with clinical outcomes of postoperative cardiac surgery-associated acute kidney injury (CSA-AKI). Data from 2488 consecutive adult patients were analyzed. Patients were classified as having CSA-AKI based on the risk, injury, failure, loss of kidney function, and end-stage kidney disease (RIFLE) criteria using peak postoperative creatinine in the postoperative intensive care unit (ICU). Multiple stepwise logistic regression analysis was used to identify independent risk factors for CSA-AKI. CSA-AKI occurred in 584 patients (23.5%). CSA-AKI patients had significantly longer aortic cross-clamp and cardiopulmonary bypass times. Furthermore, CSA-AKI patients had higher hospital mortality (5.5% vs 1.5%, PCopyright2...

CERN Document Server

As a result of nuclear power plant accidents, large areas receive radioactive inputs of Cs-137. This cesium accumulates in herbs growing in such territories. The problem is whether the herbs contaminated by radiocesium may be used as a raw material for medicine. The answer depends on the amount of Cs-137 transfered from the contaminated raw material to the medicine. We have presented new results of the transfer of Cs-137 from contaminated Digitalis grandiflora Mill. and Convallaria majalis L. to medicine. We found that the extraction of Cs-137 depends strongly on the hydrophilicity of the solvent. For example 96.5%(vol.) ethyl alcohol extracts less Cs-137 (11.6%) than 40%(vol.) ethyl alcohol or pure water (66.2%). The solubility of the cardiac glycosides is inverse to the solubility of cesium, which may be of use in the technological processes for manufacturing ecologically pure herbal medicine.

British Library Electronic Table of Contents (United Kingdom)

It is uncertain if downregulation of ?-adrenoceptor signaling pathway is promoted by an enhanced adrenergic tone at an early stage of cardiac disease, or it develops secondary to detrimental local myocardial changes in advanced heart failure. We examined the integrity of ?-adrenoceptor signaling pathway upon chronic infusion of isoproterenol, a ?-adrenoceptor agonist, at a dose producing no structural left ventricular (LV) remodeling and systolic dysfunction. Subcutaneous isoproterenol infusion (400??g?kg?1?h?1 over 16?days) to guinea pigs using osmotic minipumps produced no change in cardiac weights, LV internal dimensions, myocyte cross-sectional area, extent of interstitial fibrosis, and basal contractile function. Isolated, perfused heart preparations from isoproterenol-treated guinea ...

International Nuclear Information System (INIS)

In 9 over 12 patients who underwent cardiac transplantation computed tomography was performed. In 5 of them CT was obtained also before the surgical treatment. In all patients angio-CT technique was performed, while the ECG-gated technique was employed only before surgery. CT shows changes in morphology of both atria but over all of the right one, and rotation of the heart on the longitudinal axis. The conditions of the pericardium are particulary well demonstrated: in 5 cases pericardial effusion was observed, 3 times localized and 2 times diffuse. Only in 1 patient a small thrombus in the right atrium was demonstrated. CT allows the possibility to obtain simultaneously information on mediastinum, lung and pleura. Pleural effusion, pulmonary infections and mediastinal complications are easily demonstrated.

British Library Electronic Table of Contents (United Kingdom)

Fatalities resulted from aluminium phosphide (ALP) intoxication in completely healthy children with no preceded clinical sings or symptoms were presented. Data regarding circumstances, autopsy reports, histopathological examination, toxicological investigation, and police enquiries were also collected and evaluated. The affected children were females, and 6-16 years old. They were completely healthy and died suddenly in relation to some physical activities such as running, walking, and bathing, without any prior complain. The viscera showed intense congestion with moderate to severe pulmonary edema. The cause of the sudden termination of life in the reported cases is mostly cardiac ones. Physical exertion may precipitate death due to increased cardiac stress, increased oxygen demand, and b...

Wastenet

Environmental Protection Agency Energy Management and Conservation Program ...Environmental Protection Agency Office of Administration and Resources Management 1200 Pennsylvania Avenue, NW (3101A) ...MANAGEMENT AND ADMINISTRATION 7 Energy Management Infrastructure 7 Senior Agency Official and Energy Team 7

Energy Technology Data Exchange (ETDEWEB)

This guidebook organizes the profusion of rules and regulations surrounding radiation protection into a single-volume reference. Employee and public protection, accident prevention, and emergency preparedness are included in this comprehensive coverage. Whenever possible, information is presented in convenient checklists, tables, or outlines that enable you to locate information quickly.

Wastenet

...References | Radiation Protection | US EPA This page provides links to the reference material on EPA's Radiation Protection Web site. U.S. EPA/...OAR/ORIA/Radiation Protection Division Jump to main content. Radiation Protection Contact Us Search: All EPA This Area You are here: EPA Home ... Radiation Protection References PageName Technical Users General Public Reporters Librarians Students/Teachers PROGRAMS TOPICS REFERENCES References The Reference Section provides general material that support the ...other sections of EPA's Radiation Protection Web site. You will find links within the information to related pages throughout the Radiation Protection , EPA ...

Science.gov (United States)

The clinical manifestation of wounds of the heart is determined by the mode, site and size of the injury as well as the structure of the pericardial and myocardial lesion. Diagnosis can be confirmed by ECG and echocardiography. Only 20% of the patients with penetrating wounds of the heart live for more than 30 minutes. Pericardio-centesis should be used only to gain time for a safe sternotomy, cardiac decompression and suture of the wound of the heart. An aggressive surgical approach is mandatory. Cardiopulmonary bypass is necessary only to correct of concomitant lesions. PMID:1983618

International Nuclear Information System (INIS)

In this paper the main design requirements concerning the setting up of a telemetry ECG monitoring system are presented. The design's most important technical solutions as well as some details are also discussed. This system is intended to provide skilled medical assistance during the cardiac rehabilitation of both asymptomatic and high risk coronary patients

UK PubMed Central (United Kingdom)

Phospholamban (PLB) is a 52-amino acid integral membrane protein that helps to regulate the flow of Ca²⁺ ions in cardiac muscle cells. Recent structural studies on the PLB pentamer...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

We report a new case of Lyme disease with cardiac manifestations, which has been possible to follow during the long period of 12 years. We have detected the usual ECG abnormalities, and concentric hypertrophic myocardiopathy, by echocardiography. The acute myocarditis was demonstrated by /sup 111/In-antimyosin scintigraphy, which showed global myocardial uptake of the tracer, constituting the first report, to our knowledge, of Lyme myocarditis diagnosed by this method.

UK PubMed Central (United Kingdom)

G protein-coupled receptors (GPCRs) are known to modulate intracellular effectors involved in cardiac function. We recently reported homocysteine (Hcy)-induced ERK-phosphorylation was suppressed...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The myocardial infarct induced by isoproterenol in spontaneously hypertensive rats accumulates higher activities of /sup 99/sup(m)Tc-PM tetracycline compared with the cardiac infarct in normotensive rats caused by the same method. The isoproterenol model of the myocardial necrosis was induced in intact rats without opening the thorax and is a convenient method for experimental radioisotope studies.

International Nuclear Information System (INIS)

Several recently introduced 'new' techniques in computed tomography - iterative reconstruction, gated cardiac CT, multiple-source, and dual-energy CT - actually date back to the early days of CT. We review the historic origins and evolution of these techniques, which may provide some insight into the latest innovations in commercial CT systems. (orig.)

Energy Technology Data Exchange (ETDEWEB)

Since chlordecone (Kepone, CD) interferes with cardiac Na{sup +} ion translocases, we have studied CD effects on cardiac SR calcium pump activity. SR was isolated from heart ventricles of male Sprague-Dawley rats. Cardiac SR Ca{sup 2+}-ATPase, {sup 45}Ca-uptake and cAMP as well as calmodulin (CaM) dependent protein phosphorylation were measured. Ca{sup 2+}-ATPase was differentiated into low affinity and high affinity forms by measuring the activity using 50 and 0.7 {mu}M free Ca{sup 2+} respectively. CD in vitro inhibited {sup 45}Ca-uptake by SR in a concentration dependent manner with an IC50 value of 7 {mu}M and SR {sup 45}Ca-uptake was totally inhibited at 20-30 {mu}M CD. In agreement with this, both high affinity and low affinity Ca{sup 2+}-ATPases, which are involved in Ca{sup 2+} transport across membranes, were also inhibited by CD in a concentration dependent manner with IC50 values of 0.7 and 3.2 {mu}M ...

Science.gov (United States)

Timber harvesting histories generated by the California Department of Forestry and Fire Protection's Coast-Cascade GIS ... ...

UK PubMed Central (United Kingdom)

Protective immunity against infection with Bacillus anthracis is almost entirely based on a response to the protective antigen (PA), the binding moiety for the two other toxin components....Full Text Available

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

CERN Document Server

Nuclear plants decommissioning

International Nuclear Information System (INIS)

... pathological changes patients radiation protection radiotherapy diseases

KoreaScience (Korea)

Full Text Available

Science.gov (United States)

... harassment, incidental to construction and operation of an offshore liquefied natural gas (LNG) facility. Under the Marine Mammal Protection ... ...

Energy Technology Data Exchange (ETDEWEB)

This safety design guide for pipe rupture protection identifies high-energy systems in which pipe ruptures must be postulated to occur, as well as systems that must be protected from the dynamic effects of such ruptures. Dynamic effects considered in this SDG consist of pipe whip (including missiles generated by pipe ruptures, if any) and jet impingement, Requirements for protection against the dynamic effects of a postulated pipe rupture and method of protection of essential structures, systems and components are specified for these effects. The change status for the regulatory requirements, code and standards should be traced and this safety design guide shall be updated accordingly. 2 tabs., 5 refs. (Author) .new.

Energy Technology Data Exchange (ETDEWEB)

The feasibility of the anodic protection of titanium evaporators in Al[sub 2](SO[sub 4])[sub 3] solution was studied by the measurement of polarization curves, weight loss, solubility of passive film and AC impedance. The protection parameters and efficiency were determined. In addition, the practical technology of anodic protection was studied by screening reference electrodes and auxiliary cathodes. Throwing power was also measured. Four rows of tube-type evaporators of titanium have been anodically protected in situ. Field tests lasting more than one year shows satisfactory results. (orig.)

Science.gov (United States)

Correlates between immunological parameters and protection against Bacillus anthracis infection in animals vaccinated with protective antigen (PA)-based vaccines could provide surrogate markers to evaluate the putative protective efficiency of immunization in humans. In previous studies we demonstrated that neutralizing antibody levels serve as correlates for protection in guinea pigs (S. Reuveny et al., Infect. Immun. 69:2888-2893, 2001; H. Marcus et al., Infect. Immun. 72:3471-3477, 2004). In this study we evaluated similar correlates for protection by active and passive immunization of New Zealand White rabbits. Full immunization and partial immunization were achieved by single and multiple injections of standard and diluted doses of a PA-based vaccine. Passive immunization was carried out by injection of immune sera from rabbits vaccinated with PA-based vaccine prior to ...

International Nuclear Information System (INIS)

The minimum cardiac transit times (MTT's) at rest and following sub-maximum stresses were measured in 97 individual examinations of untrained persons and high performance athletes. It turned out that there is a strong dependence on cardiac frequency of the MTT's. This relation can be described quite satisfactorily by a hyperbolic function and in this way allows a frequency correction to be made of the MTT's. The MTT's standardized in this way (MTT.f values) represent the quotient of the end diastolic segment volume/beat volume. In the whole lesser circulatory system almost identical MTT.f values were found for the two groups under comparison at rest and following stress. In the ventricles, however, and especially so in the left ventricle, the MTT.f values were clearly higher with athletes than with untrained persons, but they strongly decreased after stresses, while the respective values remained almost constant in ordinary persons. (orig./RF).

Energy Technology Data Exchange (ETDEWEB)

The chicken extracellular matrix glycoprotein ES/130 is necessary for epithelial-mesenchymal transformation in the developing hear and is also expressed in noncardiac chicken tissues such as limb and notochord. We have identified hES, the human homology of chicken ES/130. Fluorescence in situ hybridization analysis (FISH) localizes hES to human chromosome 20p11.2-p12. FISH analyses of individuals with 20p12 deletions and affected by Alagille syndrome exclude hES as a candidate gene for this disorder. Reverse transcriptase-polymerase chain reaction studies reveal that hES is expressed in both fetal and adult human tissues and that hES expression in the left ventricle is increased in the failing adult heart. Further studies will evaluate how hES mutations may relate to congenital human cardiac and skeletal anomalies as well as cardiac remodeling in the adult. 16 refs., 2 figs.

Energy Technology Data Exchange (ETDEWEB)

The atrial myocardium has been barely visible with thallium-201 myocardial scintigraphy. This is probably related to the difference in size, distance from anterior chest wall, and small coronary blood flow of the atrium, compared with the ventricle. We have encountered eight cases of visualization of the right atrial appendix (RAA). The RAA was identified from multiple projections in all cases and sometimes confirmed by radionuclide angiocardiography. Evidence derived from ECG, chest radiographs, and cardiac catheterization, indicated that the most important factor in the visualization might be the displacement of the RAA to a more anterior position.

Energy Technology Data Exchange (ETDEWEB)

Purpose: To determine the value of MRI in the postoperativ evaluation of a singular ventricle compared to echocardiography and cardiac catheterization. Materials and methods: Thirty-one patients (range: 6 months to 30 years) with a functional single ventricle following palliative corrective operations. Five patients had a Blalock-Taussig-Shunt, 8 patients a Glenn-Anastomosis and 18 a cavopulmonary shunt (6 with classic Fontan-Circulation, 12 with modified cavopulmonary anastomosis). The results in terms of postoperative morphologic changes were compared to percutaneous echocardiography (31/31) and cardiac catheterization (6/31). Results: Echocardiography, which was performed on all patients, could not visualize the entire length of the tunnel, the Glenn-Anastomosis or the central pulmonary arteries in 70% of the patients due to an inadequate acoustic window. MRI was able to show the entire tunnel in 11/12 patients and the central pulmonary ...

British Library Electronic Table of Contents (United Kingdom)

A 60-year-old male was bitten by a venomous snake (Vipera ammodytes) and gradually developed signs of an allergic reaction including generalized itching, generalized rash, and chest discomfort. This was followed by severe retrosternal pain with electrocardiographic evidence of an inferior myocardial ischemia progressing to acute myocardial infarction. Cardiac enzymes and troponin, serum tryptase, and histamine were elevated. Coronary arteriography showed normal coronary arteries. This is a characteristic type I variant of Kounis syndrome, which is the concurrence of acute coronary syndromes with conditions associated with mast cell activation including allergic or hypersensitivity reactions as well as anaphylactic or anaphylactoid reactions. This is the first report to show that viper bite...

Energy Technology Data Exchange (ETDEWEB)

The purpose of this paper is to investigate the influence of diabetic myocardial damage (suspected myocardial damage; SMD) diagnosed by [sup 201]Tl-SPECT and diabetic cardiac autonomic neuropathy (AN) on myocardial MIBG uptake in patients with NIDDM. Eighty-seven diabetic patients divided into four subgroups: 23 with SMD (+) AN (+); 19 with SMD (+) AN (-); 27 with SMD (-) AN (+); 18 with SMD (-) AN (-), and 10 controls were studied. Both planar and SPECT images were taken at 30 minutes (early) and 3 hours (delayed) after [sup 123]I-MIBG injection. The heart to mediastinum uptake ratio (H/M) and washout ratio of [sup 123]I-MIBG (WR) were obtained from both planar images. Similarly, the difference between the [sup 201]Tl image and the [sup 123]I-MIBG image in the total uptake score (TUS) was taken as the difference in the total uptake score ([Delta]TUS) representing cardiac sympathetic denervation without SMD. On both early and delayed planar ...

Energy Technology Data Exchange (ETDEWEB)

In dynamic cardiac SPECT estimates of kinetic parameters ofa one-compartment perfusion model are usually obtained in a two stepprocess: 1) first a MAP iterative algorithm, which properly models thePoisson statistics and the physics of the data acquisition, reconstructsa sequence of dynamic reconstructions, 2) then kinetic parameters areestimated from time activity curves generated from the dynamicreconstructions. This paper provides a method for calculating thecovariance matrix of the kinetic parameters, which are determined usingweighted least squares fitting that incorporates the estimated varianceand covariance of the dynamic reconstructions. For each transaxial slicesets of sequential tomographic projections are reconstructed into asequence of transaxial reconstructions usingfor each reconstruction inthe time sequence an iterative MAP reconstruction to calculate themaximum a priori reconstructed estimate. Time-activity curves for a sumof activity in a blood ...

UK PubMed Central (United Kingdom)

Strong aqueous ammonium hydroxide used to remove N-acyl protecting groups from synthetic oligoribonucleotides causes removal of some alkylsilyl protecting groups from 2'-hydroxyls and leads to chain...Full Text Available

Science.gov (United States)

... Weiss, S., D. Kobiler, H. Levy, H. Marcus, A. Pass, N. Rothschild, and Z ... of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits ...

UK PubMed Central (United Kingdom)

Rationale: Human data suggest that the incidence of acute lung injury is reduced in patients with type II diabetes mellitus. However, the mechanisms by which diabetes confers protection...Full Text Available

UK PubMed Central (United Kingdom)

Protected areas (PAs) dominate conservation efforts. They will probably play a role in future climate policies too, as global payments may reward local reductions of loss of natural land cover. We estimate...Full Text Available

UK PubMed Central (United Kingdom)

In an attempt to establish if cross protection can be induced by different strains of Haemophilus parasuis, three groups of 12 gnotobiotic pigs were immunized each with an aluminum hydroxide adsorbed...Full Text Available

Science.gov (United States)

...2010-10-01 false Standards for health information technology to protect electronic health information...DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION...

Science.gov (United States)

...retardation, behavioral disorders or...blood. (3) Health protection goals...protecting your health. You are strongly...an independent analysis. The two...impairment of health. One of...although most cases of lead-induced...in the form of behavioral...

Energy Technology Data Exchange (ETDEWEB)

The survey of radiation protection programmes for transport has been jointly performed by three scientific organisations I.P.S.N. (France), G.R.S. ( Germany), and N.R.P.B. (United kingdom) on behalf of the European Commission and the pertaining documentation summarises the findings and conclusions of the work that was undertaken with the principal objectives to provide guidance on the establishment, implementation and application of radiation protection programmes for the transport of radioactive materials by operators and the assessment and evaluation of such programmes by the competent authority and to review currently existing radiation protection programmes for the transport of radioactive materials. (N.C.)

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

Science.gov (United States)

... Descriptors : *PROTECTIVE COATINGS, *WATER REPELLENTS, *COMBUSTIBLE CARTRIDGE CASES, COMPUTER PROGRAMS, SOLVENTS ...

Science.gov (United States)

sabot: A device fitted around or in back of a projectile in a gun barrel or launching tube to support or protect the projectile or to prevent the escape of ...

Science.gov (United States)

... CHLOROPICRIN LEAKAGE TEST Of THE M17 PPRDOtCTIVE MASK EQUIPPED WITH DRINKING AND RESUSCITATION DEVICIS WORN BY ...

KoreaScience (Korea)

Full Text Available

International Nuclear Information System (INIS)

... Sciences, Research Center for Radiation Protection, Chiba (Japan) Hafez,

Energy Technology Data Exchange (ETDEWEB)

Modern microprocessor-based relays for the protection of the various power system components such as generators, transformers, feeders, and high voltage transmission lines are becoming more sophisticated as increasingly more complex functions and capabilities can be included in the microprocessor. With this increasing complexity, and the increasing complexity of the power system itself, there is even more value in testing the suitability of relaying equipment for the intended applications. This paper reviews the testing philosophy, experience, and capabilities developed at Ontario Hydro over more than 25 years of testing protective relays.

Energy Technology Data Exchange (ETDEWEB)

In the area of seasonally thawing soil, porous or broken coatings cannot significantly retard the process of pile metal destruction, since it will occur through electroosmotic penetration of the base electrolyte to the metal surface. Such processes can be prevented by electrochemical protective methods. Systems based on grid cathode stations with power control and distribution units are recommended for use for cathode protection of steel pile foundations.

Energy Technology Data Exchange (ETDEWEB)

This manual is a guide to the services provided by the Hanford Internal Dosimetry Program (IDP), which is operated by the Pacific Northwest National Laboratory.( ) for the U.S. Department of Energy Richland Operations Office, Office of River Protection and their Hanford Site contractors. The manual describes the roles of and relationships between the IDP and the radiation protection programs of the Hanford Site contractors. Recommendations and guidance are also provided for consideration in implementing bioassay monitoring and internal dosimetry elements of radiation protection programs.

International Nuclear Information System (INIS)

Objective: To develop a computerized method of internal dose estimation on radiation protection. Methods: Based on MIRD mathematic model of the organs and by means of the programming language of MS Visual Basic 6.0, a computer program of dose estimation in internal radiation was developed for radiation protection. Results: The computerized method of dose estimation for internal radiation was completed. Conclusions: This computerized method is very convenient for internal radiation dose estimation of several aspects. It can also be used in radiation accident. (authors)

Energy Technology Data Exchange (ETDEWEB)

Simulated atmospheric corrosion studies were performed to determine the corrosion protection provided by galvanized zinc coatings on depleted uranium, U-0.75 Ti alloy, and U-6 Nb alloys. The accelerated ASTM tests consisted of exposing the galvanized samples to aqueous and aqueous chloride environments. The test results showed that anodic protection was provided by the electronegative zinc coatings on uranium and uranium alloys. Treating zinc with chromate conversion coatings also provided more protection.

Energy Technology Data Exchange (ETDEWEB)

This standard addresses the design bases for light water reactor, nuclear power plant structures and components essential for the protection of public health and safety from the potential adverse effects of pipe whip, jet impingement, pressurization of compartments outside containment, environmental conditions and flooding associated with a postulated pipe rupture. The design bases for missile protection and the design bases for containment pressurization are not within this standard.

International Nuclear Information System (INIS)

The book presents a very good account of all aspects of protection from ionizing radiation. The quantities and units are given and defined used in nuclear physics and dosimetry. The effects of ionizing radiation on cells and on man are described. The principles are presented of radiation protection including limits and valid regulations and decrees. Also discussed is internal irradiation and its modelling. A great part of the book is devoted to aspects of monitoring persons, the living and working environment and to the determination of internal contamination. The system of radiation protection in Czechoslovakia is described and some practical questions are discussed of protection during radiodiagnosis and radiotherapy, in the nuclear fuel cycle, in the operation of nuclear power installations and in crack detection. In conclusion a survey is given of the population exposure from various natural and ...

International Nuclear Information System (INIS)

There are many differences between industrial CT and industrial radiography, such as imaging principle, inspection time, radiation dose and the requirements for operators etc. The national standards for radiation protection of industrial detection are not applicable to the requirements of protection and safety for #gamma#-ray industrial CT to some extent now. In order to standardize the production and use for #gamma#-ray industrial CT, protect the safety of operators and the public, and to promote the popularization and application of #gamma#-ray industrial CT, it is significant to establish the national standards for radiation protection of #gamma#-ray industrial CT as soon as possible. The purpose of this paper is to introduce the contents of this standard, and specify some important terms. Then there is a brief discussion on the existing problems during establishing such standards. At last, the paper ...

Energy Technology Data Exchange (ETDEWEB)

This works evaluates by punctuation the performance in conventional Brazilian industries radiation protection area which make use of small industrial gauges and industrial radiography. It proposes, procedures for industry self-evaluation, besides a new radiation protection plans pattern for the small industrial gauges area. The data source where inspection reports of Dosimetry Radiation Protection Institute/Nuclear Energy Commission conventional Brazilian industries' radiation protection plans, beyond visitation to the inspection place. The performance evaluation has been realized both in the administrative and operational aspects of the industries. About of 60% of the industries have a satisfactory register control which does not happen to the operational control. The performance evaluation advantage is that industries may self-evaluate, foreseeing Dosimetry Radiation ...

Science.gov (United States)

Hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) is a genetic disorder with autosomal dominance, variable penetrance, and an estimated prevalence of 1/10,000 inhabitants in France. Diagnosis is based on clinical criteria including epistaxis, telangiectasia, visceral manifestations, and familial occurrence. Pulmonary arteriovenous malformations, present in 15-33% of patients, are its primary visceral complications. The disease may be revealed by infectious and ischemic neurological manifestations due to paradoxical embolism. The high frequency of neurologic complications even in asymptomatic patients justifies systematic screening for pulmonary arteriovenous malformations. Treatment of these malformations is based on percutaneous transcatheter coil embolization of the feeding artery. Pulmonary arterial hypertension is rare in this disease. It may be due to systemic arteriovenous shunting in the liver, which increases cardiac output, or be similar to ...

British Library Electronic Table of Contents (United Kingdom)

Objective Comorbidities predisposing cardiac surgical patients toward deep sternal wound infection, such as diabetes and obesity, are rising in the United States. Longitudinal analysis of risk factors, morbidity, and mortality was performed to assessed effects of these health trends on deep sternal wound infection rates. Methods In this retrospective analysis of all median sternotomies performed at a single institution from 1991 through 2006, demographic and surgical characteristics were identified from a prospective database. The cohort was separated into periods from 1992 through 2001 and 2002 through 2006 to identify longitudinal trends in risk factors for deep sternal wound infection. Univariate and matched multivariable analyses were performed. Results Overall, study population had in...

Energy Technology Data Exchange (ETDEWEB)

Cellular telephones emit a radiofrequency electromagnetic field, part of which is absorbed in the user's head. Many studies have been conducted to look for their possible health hazard to human, at the experimental, epidemiological or clinical level. After a short recall on dosimetry, the author describes the state-of-the art about harmful and irreversible effects, up to now not confirmed, and about some benign symptoms which look absolutely actual. A causal relationship of the electromagnetic field on these benign symptoms is however not proven; other, studies are running to evaluate their possible long-term consequences. Interferences with cardiac pacemakers can easily be avoided by holding the telephone handset farther than 10 cm. (author)

British Library Electronic Table of Contents (United Kingdom)

Animal studies demonstrated the powerful impact of maternal-infant social contact on the infant's physiological systems, yet the online effects of social interactions on the human infant's physiology remain poorly understood. Mothers and their 3-month old infants were observed during face-to-face interactions while cardiac output was collected from mother and child. Micro-analysis of the partners' behavior marked episodes of gaze, affect, and vocal synchrony. Time-series analysis showed that mother and infant coordinate heart rhythms within lags of less than 1s. Bootstrapping analysis indicated that the concordance between maternal and infant biological rhythms increased significantly during episodes of affect and vocal synchrony compared to non-synchronous moments. Humans, like other mamm...

International Nuclear Information System (INIS)

The authors used studies of local cerebral metabolic rate for glucose (LCMRGlc) to examine development of cerebral organization in 5 days to 1 year old children. A group (n=8) of infants with diverse pediatric disorders allowed investigation of developmental changes in LCMRGlc, while also providing relevant clinical management information. Patients consisted of questionable and definite neonatal seizures, cerebral embolism from cardiac sources, and otherwise normal infants with facial nevi with consideration of Sturge-Weber. Gradual increase in cortical LCMRGlc coincides with suppression of intrinsic subcortical reflexes present in all newborns. Two retarded children (2 years old) showed LCMRGlc developmental patterns of a few days old, which corresponded to their functional and mental status. These studies illustrate great potential of PET to study normal and altered states of human brain development.

British Library Electronic Table of Contents (United Kingdom)

Aim:To examine the electrophysiological effects of sophocarpine on action potentials (AP) and ionic currents of cardiac myocytes and to compare some of these effects with those of amiodarone.Methods:Langendorff perfusion set-up was used in isolated guinea pig heart, and responses to sophocarpine were monitored using electrocardiograph. Conventional microelectrode, voltage clamp technique and perforated patch were employed to record fast response AP (fAP), slow response AP (sAP) and ionic currents in guinea pig papillary muscle or rabbit sinus node cells.Results:Tachyarrhythmia produced by isoprenaline (15 ?mol/L) could be reversed by sophocarpine (300 ?mol/L). Sophocarpine (10 ?mol/L) decreased the amplitude by 4.0%, maximal depolarization velocity (Vmax) of the fAP by 24.4%...

Science.gov (United States)

Electric utilities have been surprised by recent opposition to the construction of very-high-voltage transmission lines, which met with little resistance in the past. Concerns over health and safety factors are associated with the increase in the number of such lines, although their presence has always been an inconvenience and a hazard for those living and working in the immediate vicinity. The new lines present additional hazards due to the continuous flow of small electric currents and the charges that build up in the area of the towers and lines. The lines are also a threat to persons wearing cardiac pacemakers. There is experimental evidence from the Soviet Union and the U.S. that electric and magnetic fields at the frequencies of such power lines can have serious biological effects on growth rates and the functioning of the central nervous system. Full disclosure that possible risks are involved and the opportunity to avoid these risks is a public ...

Environmental Research Database

Summary'THE ROLE OF THE UK PLANNING SYSTEM IN PROTECTING AND ENHANCING SOILS PROJECT REF: UKLQ01 APRIL 2004 INTRODUCTION Soil has long been overlooked in environmental planning. Whilst it has sometimes benefited from indirect protection, until recently its importance and vulnerability have not been reflected in more explicit strategies. This study explored the current and potential role of the planning system in protecting and enhancing soils. Soil is the physical material that covers much o [continued...]DescriptionSNIFFER has commissioned this study on behalf of SEPA, SNH, EHS and the Environment Agency for England and Wales. These UK agencies have an interest in protecting soil quality through a combination of direct regulation of emissions to land, protection of designated sites of special value or sensitivity and engaging other regulatory regimes such as land use planning. All ...

International Nuclear Information System (INIS)

Nanowires of copolymers film based on aniline and 1-amino-2-naphthol-4-sulphonic acid were electrochemically synthesized on the iron electrode by cyclic voltammetry using oxalic acid as a supporting electrolyte. Protective properties of copolymer film on the iron surface in 1.0 M HCl solution was investigated by chronoamperometry, potentiodynamic polarization technique and electrochemical impedance spectroscopy (EIS). The results showed that the copolymer film showed the significant shifting in the corrosion potential and greater charge transfer resistance. Moreover, the copolymer showed the larger degree of surface coverage onto the iron surface, reflecting the higher protection for corrosion of the iron in acidic medium. In addition, the film constitutes a physical as well as a chemical barrier layer due to the presence of -OH and -NH groups in ANSA unit, which provides passivity protection in polymer coatings. The ...

Science.gov (United States)

... Airframe System Technoloqies Laser fabricated flooring Composite sandwich panels for noise control Spray formed HS aluminum alloys Protective ...

International Nuclear Information System (INIS)

German translation of the publication 'The evaluation of risks from radiation' published in 1965 by the International Commission on Radiological Protection. In a survey, genetic and somatic risks from radiation are presented and explained. (HP).

UK PubMed Central (United Kingdom)

Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG repeats) bound to an array of specialized...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This report describes the status of nuclear safety and radiation protection in the facilities of the AREVA group and gives information on radiation protection in the service operations, as observed through the inspection programs and analyses carried out by the General Inspectorate in 2007. Having been submitted to the group's Supervisory Board, this report is sent to the bodies representing the personnel. Content: 1 - A look back at 2007 by the AREVA General Inspector: Visible progress in 2007, Implementation of the Nuclear Safety Charter, Notable events; 2 - Status of nuclear safety and radiation protection in the nuclear facilities and service operations: Personnel radiation protection, Event tracking, Service operations, Criticality control, Radioactive waste and effluent management; 3 - Performance improvement actions; 4 - Description of the General Inspectorate; 5 - Glossary.

International Science & Technology Center (ISTC)

Elaboration of a Modern Technology for Operational Agrometeorological Soil Moisture Monitoring Spring Wheat, Yield and Disease Damage Forecasting and Recommendations for Plant Protection on the Kazakhstan Territory

British Library Electronic Table of Contents (United Kingdom)

Aims: Rapamycin (sirolimus) is an antibiotic that inhibits protein synthesis through mammalian targeting of rapamycin (mTOR) signaling, and is used as an immunosuppressant in the treatment of organ rejection in transplant recipients. Rapamycin confers preconditioning-like protection against ischemic-reperfusion injury in isolated mouse heart cultures. Our aim was to further define the role of rapamycin in intracellular Ca^2^+ homeostasis and to investigate the mechanism by which rapamycin protects cardiomyocytes from hypoxic damage. Main methods: We demonstrate here that rapamycin protects rat heart cultures from hypoxic-reoxygenation (H/R) damage, as revealed by assays of lactate dehydrogenase (LDH) and creatine kinase (CK) leakage to the medium, by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-d...

British Library Electronic Table of Contents (United Kingdom)

Gas nitridation has shown excellent promise to form dense, electrically conductive and corrosion-resistant Cr-nitride surface layers on Ni-Cr base alloys for use as proton exchange membrane fuel cell (PEMFC) bipolar plates. Due to the high cost of nickel, Fe-base bipolar plate alloys are needed to meet the cost targets for many PEMFC applications. Unfortunately, nitridation of Fe-base stainless steel alloys typically leads to internal Cr-nitride precipitation rather than the desired protective surface nitride layer formation, due to the high permeability of nitrogen in these alloys. This paper reports the finding that it is possible to form a continuous, protective Cr-nitride (CrN and Cr2N) surface layer through nitridation of Fe-base stainless steel alloys. The key to form a protective Cr...

UK PubMed Central (United Kingdom)

In most adult tissues there reside pools of stem and progenitor cells inside specialized microenvironments referred to as niches. The niche protects the stem cells from inappropriate expansion...Full Text Available

Science.gov (United States)

A waterjet coating-removal system was developed at NASA's Marshall Space Flight Center in Huntsville, Ala., to remove thermal protective coatings from the ...

Science.gov (United States)

Sep 18, 2007 ... Lightweight structural aerogels would find applications as a component of composite sandwich panels that are both lightweight and insulating ...

International Nuclear Information System (INIS)

Russian (Mar 1977). USSR Makarov, VA Zarubin, PI Mironov, Yu.M.

British Library Electronic Table of Contents (United Kingdom)

Abstract The World Bank is the largest international funder of biodiversity conservation. It invests in protected areas to conserve species and spaces, protect ecosystems, and provide food, shelter, and other ecosystem services to local communities. It spends on average, $275 million annually supporting parks in developing countries. We examined their protected areas investment portfolio from 1988 to 2008 to understand how they allocate these funds. We found that more money is allocated to countries with progressively larger GDPs. Many, but not all, of these investments correlate with consensus opinions of high biodiversity priorities. But the World Bank's investments are not proportional; poorer countries receive relatively more funds than richer ones, regardless of biodiversity importanc...

Science.gov (United States)

This standard establishes requirements, verification criteria, and contractor tasks for electromagnetic effects protection of airborne, ground, and support systems. These effects include electromagnetic compatibility, electromagnetic interference, lightni...

Science.gov (United States)

... is reduced: 1) by lack of oxygen, 2) in hypercapnia associated with closed rooms or tents, 3) by use of sleeping drugs, antipyretics, insulin, and 4 ...

UK PubMed Central (United Kingdom)

OBJECTIVES:To investigate the effect of opioid receptor blockade on the myocardial protection conferred by chronic exercise and to compare exercise training with different strategies...Full Text Available

UK PubMed Central (United Kingdom)

Recall from visual memory is vulnerable to the influence of task-irrelevant information, including the remembered, prototypical value of stimuli seen previously. Wilken...Full Text Available

International Nuclear Information System (INIS)

Russian (Jan 1976). USSR Mironov, Yu.M. Makarov, VA Nauchno-

Energy Technology Data Exchange (ETDEWEB)

Anodic protection makes it possible to keep materials which can be passivated in a 'passive' state or to bring them into this state, even in unfavourable conditions. With sulphuric acid concentrations of 93-99% this method permits the use of inexpensive, stainless austenitic steels, e.g. 1.4541 and 1.4591, at temperatures of up to 160/sup 0/C. The temperature range from 120/sup 0/C, in particular, is suitable for heat recovery. Anodic protection by the APR-system provides safe and low-cost protection for air coolers and bare tube coolers in sulphuric acid plants. The results of laboratory, pilot plant and commercial trials show that in this way a safe operation of sulphuric acid coolers is possible on a long-term basis.

Science.gov (United States)

... reliability of fiber optics in preference over space-based systems. ... STC web site at www.aiaa.org/tc ... and improve lethalities of US weapon systems 3 ...

Energy Technology Data Exchange (ETDEWEB)

The AZSh protective circuit breakers developed by the VNIIVEh Institute and the Prokop'evsk plant for mine automation will replace a number of circuit breaker systems used in underground coal mines in the USSR. The standardized AZSh circuit breaker generation consists of 3 basic types: the AZSh-1, the AZSh-2 and the AZSh-3 systems for power systems with 380 or 660 V voltage. Block scheme of the AZSh system is given. Its specifications are discussed. The AZSh circuit breakers are used for protection of transformer stations from overload and heating as well as for automatic shutdown of energy supply to a power system in emergency situations. Design, basic elements and operation of the AZSh-1, the AZSh-2 and the AZSh-3 protective circuit breakers is evaluated. Commercial production of the AZSh started in 1983.

Science.gov (United States)

A common reinforced liner material is a cloth formed of PTFE fibers and fiber of ... and ablation protection provided. All of these methods of thermal ..... The influence of fiber content on the microstructures of the composites is ...

International Nuclear Information System (INIS)

Male rats were injected intravenously for 15 min with physiological saline (as control) (0.05 #mu#g/kg/min) or norepinephrine (NE) (0.1 #mu#g/kg/min) followed by 740 kBq of MIBG. Rats were injected for more 30 min (early stage group) and for more 4 hr (late stage group) with physiological saline or NE. Five MBq of "9"9"mTc-tetrofosmin (TF) was administered instead of MIBG in another group. The heart was isolated and uptake of MIBG or TF of right ventricle, apex, and left ventricle (divided into 8 parts) was measured. In control group, MIBG uptake of apex was significantly lower than that of lateral wall in both early and late groups. In NE group, MIBG uptake showed a tendency to decrease in both early and late groups. Compared with control group, the uptake of anterior wall in late group decreased significantly at NE 0.1 #mu#/kg/min. The TF uptake in control group was not different in each part. In NE group, the TF uptake of right ventricle decreased significantly compared with that of ...

Energy Technology Data Exchange (ETDEWEB)

Scour around offshore structures is well known. It is caused by the strong eddy formation at the base of the structures protruding from the sea bottom. The strong vortices result in an amplified effective shear stress working on the sea bottom surface adjacent to the structure. When the surrounding sea bottom is lowered the scour protection will end up being a cap on a small hill and when the slopes are getting too steep the scour protection will roll or slide down the sides. It will loose its cohesion and therefore its integrity. This will take place irrespective of the type of scour protection material and the type of scour protection. This report describes scour protections, which can deal with this particular problem. Such a scour protection must be able to sustain the following loads: Be able to follow the lowering of the seabed on its way down; Be ...

Energy Technology Data Exchange (ETDEWEB)

The Montreal Protocol provides the international community with an effective equitable and dynamic mechanism for protecting the ozone layer. The paper uses the Protocol's negotiating history to describe how and why agreement on a particular issue was reached and provides an in-depth analysis of the Protocol's most innovative provisions. The paper discusses international implementation of the Protocol. It concludes with a brief description of recent developments leading up to the Protocol's possible modification in June 1990. (14 refs.).

International Nuclear Information System (INIS)

Based on the reliability analysis methods of FMEA and FTA, according to the result of ETA of PRA in Daya by NPP, the top events of the fault trees of reactor protection system and the success criteria were established. By using RISK-SPECTRUM procedure, the unavailability and the minimal cut-sets (MCS) of the fault trees were obtained. The results of analysis was put into the visual risk analysis software of Daya bay NPP as the support of data

Energy Technology Data Exchange (ETDEWEB)

This document presents the SSI preliminary views and position concerning the decommissioning of nuclear plants. To prevent the exposure of the decommissioning personnel and the general public to unacceptable levels of radiation and to protect the environment and future generations, it is SSI`s task to formulate and issue the necessary terms and regulations with which the reactor licensees must comply during the decommissioning work. The views and principles presented here are the basis of SSI`s continued work on guidelines and regulations for the decommissioning of nuclear plants.

Energy Technology Data Exchange (ETDEWEB)

This Test Plan outlines the testing to be done on the Special Protective Coating (SPC) Polyurea which includes: Tank Waste Compatibility, Decontamination Factor Testing, and Adhesion Strength Testing after a sample has been exposed to Radiation.

Energy Technology Data Exchange (ETDEWEB)

Hydrogen uptake and embrittlement of tantalum by electrolytically produced hydrogen is investigated on samples of varying composition and type of pretreatment. Of decisive influence on the uptake of hydrogen are the oxide layers present on the tantalum surface. By contact with platinum group metals as alloying constituents, surface coatings or anodic protection, a protection of tantalum can be obtained depending on the experimental conditions.

Energy Technology Data Exchange (ETDEWEB)

Often measures of protection and restoration of reinforced concrete structures are not taken until damage occurs which affects power plant operation. These failures can be avoided by predictive civil engineering maintenance and repair. The consequent application and implementation of a life-time management system for power plant buildings is being suggested. (orig.)

Environmental Research Database

DescriptionFollowing publication of the Curry report, DEFRA have made a commitment to establish a number of pilot projects supporting a network of demonstration and development farms. These 'farms' are intended to support the process of technology transfer by giving free access to information on the practical application of new, emerging and best practice technologies. Protected Horticulture has been identified as a sub-sector requiring the establishment of one of these projects. One of the major pressures [continued...

International Nuclear Information System (INIS)

This monograph provides basic notions and principles in dosimetry and radiation protection in compliance with two fundamental works: IAEA Safety Series No.115 - International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources - and Publication no. 60 of International Commission on Radiological Protection. After the review of quantities and units necessary in radiation protection, the book presents the new values of dose limits as well as the values of 'radiation weighting factor', 'tissue weighting factor' and 'conversion factor intake-dose' (committed effective dose per unit intake) by ingestion and inhalation for 30 most important radionuclides. The new values of dose limits, lower than the old values, are a challenge for the radiation protection, especially of the 'public' where the dose limit diminished by a factor of five ...

Energy Technology Data Exchange (ETDEWEB)

The report presents a brief synopsis and discussion of wildlife activities undertaken by Bonneville Power Administration. The objectives of the program were wildlife protection, mitigation, and enhancement planning; and implementation of actions to protect, mitigate, and enhance wildlife affected by development and operation of hydroelectric facilities in the Columbia River Basin. (ACR)

International Nuclear Information System (INIS)

Reactor COre Protection System (RCOPS), an advanced core protection calculator system, is a digitized one which provides core protection function based on two reactor core operation parameters, Departure from Nucleate Boiling Ratio (DNBR) and Local Power Density (LPD). It generates a reactor trip signal when the core condition exceeds the DNBR or LPD design limit. It consists of four independent channels adapted a two-out-of-four trip logic. System configuration, hardware platform and an improved algorithm of the newly designed core protection calculator system are described in this paper. One channel of RCOPS was implemented as a single channel facility for this R and D project where we performed final integration software testing. To implement custom function blocks, pSET is used. Software test is performed by two methods. The first method is a 'Software Module Test' and the second method is a ...

Energy Technology Data Exchange (ETDEWEB)

Laser applications have proliferated in recent years and, as to be expected, their presence is no longer confined to the laboratory or places where access to their radiation can be easily controlled. One obvious application where this is so is in military operations where various devices such as laser range finders, target designators, and secure communications equipment elevate the risk of exposure, specifically eye exposure, to unacceptable levels. Although the need for eye protection in the laboratory and other controlled areas has been appreciated since the invention of the laser, the use of lasers in circumstances where safety or the risk of temporary loss of vision, which can not always be ensured by administrative procedures, has made adequate eye protection essential. It is the critical nature of many military operations that has driven the search for eye protection against both nuclear and laser radiation. At the ...

International Nuclear Information System (INIS)

One of the methods to protect a carbon steel material from corrosion attack of sulfuric acid environment is with anodic protection. This research was intended to investigate the effect of anodic protection quickened with potential polarization, The material under investigation were ASTM A 516 and JIS G 3131-SPHC in highly concentrated H_2SO_4 solution. The results showed that potential that was effective for anodic protection in ASTM A 516-60 were at 236-436 mV for 75%, 276-476 mV for 80%, 264-514 mV for 85%,285-485 mV for 90%, and 231-431 mV for 97% H_2SO_4 so that in JlS G 3131-SPHC were at 303 -503 mV for 75%, 290-490 mV for 80%, 269- 516 mV for 85%, 264-514 mV for 90%, and 287 -487 mV for 97% H_2SO_4.

International Nuclear Information System (INIS)

Environmental Impact Assessment (EIA) must account for legally protected and endangered species. Uncertainties relating to the validity and sensitivity of EIA arise from predictions and valuation of effects on these species. This paper presents a validity and sensitivity analysis of a model (BIO-SAFE) for assessment of impacts of land use changes and physical reconstruction measures on legally protected and endangered river species. The assessment is based on links between species (higher plants, birds, mammals, reptiles and amphibians, butterflies and dragon- and damselflies) and ecotopes (landscape ecological units, e.g., river dune, soft wood alluvial forests), and on value assignment to protected and endangered species using different valuation criteria (i.e., EU Habitats and Birds directive, Conventions of Bern and Bonn and Red Lists). The validity of BIO-SAFE has been tested by comparing predicted effects of landscape ...

Energy Technology Data Exchange (ETDEWEB)

Although destruction of United States wetlands has slowed, their continued conversion, especially in certain inland regions of the country, may pose adverse ecological effects over the next few decades. The Army Corps of Engineers' regulatory program (Section 404 of the Clean Water Act) protects most coastal wetlands, but provides no protection for 95% of the country's wetlands which remain inland. These inland, freshwater wetlands, converted for agricultural purposes, comprise 80% of the wetland losses over the past 30 years. This report outlines options for more effective federal management, such as the mapping and categorizing of wetlands to determine relative values. In effect, agencies can focus protection programs on higher-value wetlands, especially those threatened by agricultural conversion. The report also discusses the contradictory federal policies aimed at wetlands; for example, the tax code ...

Energy Technology Data Exchange (ETDEWEB)

The Environmental Protection Agency (EPA) is developing generally applicable environmental standards for land disposal of Atomic Energy Act (AEA) low-level radioactive wastes (LLW) and certain naturally occurring and accelerator-produced radioactive material (NARM) wastes. It is EPA's intention that the LLW standards will protect public health and the environment. The LLW standards would cover disposal of all AEA materials not controlled by other EPA standards and some natural radioactive materials. Coverage of federal waste is significant, because the federal government generates and disposes of >40% of all LLW nationwide, and a uniform standard for all LLW disposal is both a desirable and an achievable goal. Publication of a proposed LLW standard is planned in 1988, and a final standard a year later. This standard will have several important and closely related areas of focus which are discussed in the paper.

International Nuclear Information System (INIS)

In defining criteria for good protection against ionizing radiation, it is important to assess quantitatively the likely risk of any radiation exposure. The 'somatic' risks to the individual result mainly from induction of cancer in the organs irradiated, and these risks can now be estimated on the basis of numerous detailed epidemiological surveys of exposed human populations. Estimates of the risk of hereditary effects, from genetic changes induced in germ cells, are based largely on the frequency with which such effects are induced in other species. In both cases the risk at very low dose can be inferred using knowledge of the way in which radiation damage is caused in tissues. Coherent systems of radiation protection are based on a restriction of doses to the whole body and to individual organs, such that the induction of cancer and genetic harm is infrequent, and the threshold dose for causing other, 'non-stochastic', effects is not ...

International Nuclear Information System (INIS)

Protective goals set the line of orientation of tasks and activities in the field of accident prevention. They have to be based on safety-science methods in order to develop from the conceptual idea to the practically feasible solution, while using the scientific methods to take into account the facts and the capabilities of a situation and, proceeding from them, finding an efficient and rational, optimal pragmatic approach by way of various strategies or tactics. In this process, the activities of defining, informing, thinking and developing need the proper terminology. Safety is absence of danger, protection is limitation of danger and prevention of damage. So it is protection what is needed with danger being given, and risks have to be minimized. Riskology is a novel method of safety science, combining risk analysis and risk control into a systematic concept which is practice-oriented. Applying this to the field of ...

British Library Electronic Table of Contents (United Kingdom)

Radiofrequency electromagnetic fields (EMF) are harmful to public health, but the certain anti-irradiation mechanism is not clear yet. The present study was performed to investigate the possible protective effects of green tea polyphenols against electromagnetic radiation-induced injury in the cultured rat cortical neurons. In this study, green tea polyphenols were used in the cultured cortical neurons exposed to 1800?MHz EMFs by the mobile phone. We found that the mobile phone irradiation for 24?h induced marked neuronal cell death in the MTT (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl-tetrazolium bromide) and TUNEL (TdT mediated biotin-dUTP nicked-end labeling) assay, and protective effects of green tea polyphenols on the injured cortical neurons were demonstrated by testing the content ...

British Library Electronic Table of Contents (United Kingdom)

The aim of the present investigation was to study the effect of weather and available protection on the behaviour of outdoor-wintered beef cattle (Bos taurus). A herd of 78-85 cattle head was studied during four winter months in the Southwest of Sweden. Protection was offered by coniferous forest situated on and around the 12ha pasture, which we divided into protection categories. During 240h we observed 10 cows and 10 heifers as focal animals (each 3h/month) during day time and adjusted observation times to the altitude of the sun. Close to the animals and at an unprotected spot of the pasture we measured temperature, wind speed and solar radiation and combined these variables to a single measure called Wind Chill Temperature (WCT). During observations the animals were in the forest in 12...

Energy Technology Data Exchange (ETDEWEB)

This book is mainly a comparison of the cost of pollution with the cost of environmental protection. As to the causes of pollution, a difference is made between pollutants that accumulate and pollutants that do not accumulate. Because of pollutant accumulation it is necessary to carry out both subsequent pollution abatement measures and to take preventive action which helps to avoid pollutant emission. Growth models serve to substantiate why such preventive action is both ecologically and economically useful as a rule. Finally the study makes a comparison between some tools of environmental protection. It stresses in particular that, if a duty on emissions is levied, the polluter has to bear all the cost of the pollution, while at the same time the quality of the environment can be more successfully improved than by emission standards alone.

International Nuclear Information System (INIS)

During fluoroscopy the examiner is usually protected by a radiation-reducing body shield, leaving the thyroid unprotected. The fact that the thyroid is located in a region of the neck usually covered by the shirt collar led to the idea of designing a tie with lead core, providing easy and ''decorative'' reduction of the radiation dose. Sonographic examinations were carried out in 20 volunteers (10 men, 10 women) to determine the size of the gland and its coverage by such a tie. The reduction of the surface and organ dose was assessed using film dosimetry with scattered radiation, the body of the examiner being simulated by an Alderson phantom. On average 88% of the thyroid gland surface area was covered. Surface dose was reduced to 1%, and organ dose to 10% of the value without the protection tie. (Author).

Energy Technology Data Exchange (ETDEWEB)

The Department of Energy (DOE) policy requires that all DOE activities be conducted in a manner that protects the safety of the public and provides a safe and healthful workplace for employees. DOE has also prescribed that all personnel be protected in any explosives operation undertaken. The level of safety provided shall be at least equivalent to that of the best industrial practice. The risk of death or serious injury shall be limited to the lowest practicable minimum. DOE and contractors shall continually review their explosives operations with the aim of achieving further refinements and improvements in safety practices and protective features. This manual describes the Department's explosive safety requirements applicable to operations involving the development, testing, handling, and processing of explosives or assemblies containing explosives. It is intended to reflect the state-of-the-art in explosives ...

Energy Technology Data Exchange (ETDEWEB)

The project was initiated in 1985 with the goal of studying existing federal, state, and local programs for protecting and preserving Cape Cod's sole-source aquifer. To meet this need, the Massachusetts Department of Environmental Quality Engineering and the U.S. Environmental Protection Agency's Region 1 in cooperation with the Cape Cod Planning and Economic and Development Commission and the U.S. Geological Survey initiated a two-year study to determine the adequacy of current ground-water protection programs and to recommend improvements. In the process of gathering and evaluating hydrogeological data from the Towns of Barnstable and Eastham, the CCAMP Aquifer Assessment Committee developed the papers which are the subject of this publication. These studies formed the technical basis for groundwater resource management decision making.

Energy Technology Data Exchange (ETDEWEB)

The work examines twenty-two patients with coronary artery disease, previous myocardial infarction and LV dysfunction, using the technetium-99m ({sup 99m}Tc) tetrofosmin (SPECT) associated with nitrate administration in the detection of hypoperfused but still viable myocardium. The method allows the detection of this disease. [Italian] Il lavoro analizza i risultati degli esami condotti su 22 pazienti con cardiopatia ischemica cronica e ridotta funzione ventricolare sinistra sottoposti a tomografia computerizzata con emissione di fotone singolo (SPECT) cardiaca con tecnezio-99m ({sup 99m}Tc) tetrofosmina associata alla somministrazione di nitrati nella differenziazione tra tessuto miocardico ipoperfuso ma ancora vitale e tessuto miocardico necrotico. La metodologia usata consente di identificare la presenza di tessuto miocardico vitale in territori vascolari severamente ipoperfusi.

International Nuclear Information System (INIS)

Quantitative gated SPECT (QGS) was evaluated in 7 normal volunteers and 31 patients with cardiac diseases. Adequate cut off value of a prefilter was 0.45. In phantom, the left ventricular volume value was 93.9% of determined value by 180-degree projection in L type and 98.8% by 360-degree projection in opposed type. In normal volunteers, LVEF measured by QGS program related to value by first pass method. As for functional map, regional EF and wall motion decreased at the septum side, and wall thickening at base side of heart. Good correlation was recognized (p<0.0001) between blood flow image and functional map (regional EF and wall thickening). In 20 cases of acute myocardial infarction, lesion was detected conspicuously in regional EF and wall motion. The accuracy of coronary arterial stenosis improved in functional map (regional EF 92%, wall motion 92% and wall thickening 88%). In particular, the accuracy of 3 rami lesion was 100% in functional map and higher ...

Energy Technology Data Exchange (ETDEWEB)

RADIANT{trademark} is manufactured by United States Surgical Corporation, Vascular Therapies Division, (formerly Progressive Angioplasty Systems). The system comprises a liquid {beta}-radiation source, a shielded isolation/transfer device (ISAT), modified over-the-wire or rapid exchange delivery balloons, and accessory kits. The liquid {beta}-source is Rhenium-188 in the form of sodium perrhenate (NaReO{sub 4}), Rhenium-188 is primarily a {beta}-emitter with a physical half-life of 17.0 hours. The maximum energy of the {beta}-particles is 2.1 MeV. The source is produced daily in the nuclear pharmacy hot lab by eluting a Tungsten-188/Rhenium-188 generator manufactured by Oak Ridge National Laboratory (ORNL). Using anion exchange columns and Millipore filters the effluent is concentrated to approximately 100 mCi/ml, calibrated, and loaded into the (ISAT) which is subsequently transported to the cardiac catheterization laboratory. The delivery catheters are modified ...

International Nuclear Information System (INIS)

The contribution of platelets and clotting factors in thrombosis on cardiovascular prostheses had been quantified with several tracers. Thrombus formation in vivo could be measured semiquantitatively in animal models and patients with indium-111, Technetium-99m labeled platelets, iodine-123, iodine-131 labeled fibrinogen, and In-111 and Tc-99m labeled antibody to the fibrinogen-receptor on the platelet- membrane, or fibrin. The early studies demonstrated that certain platelet-inhibitors, e.g. sulfinpyrazone, aspirin or aspirin- persantine increased platelet survival time with mechanical valves implanted in the baboon model and patients. Thrombus localization by imaging is possible for large thrombus on thrombogenic surface of prosthesis in the acute phase. The majority of thrombus was found in the sewing ring (Dacron) in the acute phase in both the mechanical and tissue valves. The amount of retained thrombus in both mechanical and tissue valves in our one-day study in the dog model ...

DEFF Research Database (Denmark)

The sources of non-white noise in Blood Oxygenation Level Dependent (BOLD) functional magnetic resonance imaging (fMRI) are many. Familiar sources include low-frequency drift due to hardware imperfections, oscillatory noise due to respiration and cardiac pulsation and residual movement artefacts not accounted for by rigid body registration. These contributions give rise to temporal autocorrelation in the residuals of the fMRI signal and invalidate the statistical analysis as the errors are no longer independent. The low-frequency drift is often removed by high-pass filtering, and other effects are typically modelled as an autoregressive (AR) process. In this paper, we propose an alternative approach: Nuisance Variable Regression (NVR). By inclusion of confounding effects in a general linear model (GLM), we first confirm that the spatial distribution of the various fMRI noise sources is similar to what has already been described in the literature. Subsequently, we ...

International Nuclear Information System (INIS)

There is increasing use of radiofrequency radiation (RFR) in industry for communications, welding, security, radio, medicine, navigation etc. It has been recognised for some years that RFR may interact with cardiac pacemakers and steps have been taken to prevent this interference. It is less well recognised that other metallic implants may also act as antennas in an RFR field and possibly cause adverse health effects by heating local tissues. There are a large and increasing number of implants having metal components which may be found in RFR workers. These implants include artificial joints, rods and plates used in orthopaedics, rings in heart valves, wires in sutures, bionic ears, subcutaneous infusion systems and (external) transdermal drug delivery patches"1. The physician concerned with job placement of such persons requires information on the likelihood of an implant interacting with RFR so as to impair health. The following outlines the approach developed in ...

International Nuclear Information System (INIS)

MRI provides a non-invasive diagnostic tool complementing echocardiography on one hand, and showing advantages over echocardiography, on the other hand, especially after corrective procedures. The multiple different MRI sequences need to be adapted to examinations of children and patients with congenital heart disease (CHD), and can be used to detect morphologic changes, blood-flow in the heart and thoracic vessels and diastolic or systolic function of myocardium. Several factors determine the success of the examination of a complex congenital heart disease or a postoperative situs. Pediatric radiologists and radiologists experienced in congenital heart diseases have to work in close cooperation. Echocardiography should be performed before MRI. The results of prior examinations and the clinical history of the patients, including possible palliative or reconstructive operations, must be available before MRI to guide the planning of the examination. With a systematic segmental approach ...

Science.gov (United States)

The endothelin-B (ETB) receptor is a G-protein-coupled receptor that binds endothelin ligands and is essential for the development of epidermal melanocytes and enteric neurons. Recent reports indicate that ETB is localized to nuclei in cardiac ventricular myocytes, although it has been thought that ETB is localized mainly on the plasma membrane. It remains unknown, however, whether this unique distribution of ETB occurs in other tissues. To elucidate the subcellular distribution of ETB in the intestine, we performed immunofluorescence of ETB in mouse intestine using a specific antibody. ETB-like immunoreactivity was detected in both the mucosal and muscle layers. In the mucosal layer, villous epithelial cells, stromal cells of the lamina propria, and cryptic cells were immunostained. Subcellularly, ETB is localized mainly to the nuclei of villous epithelial cells. In the muscle layer, immunoreactivity of ETB was localized to the myenteric plexus. These findings ...

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study was to determine whether low doses of carbon monoxide (CO) exacerbate myocardial ischemia during a progressive exercise test. The effect of CO exposure was evaluated using the objective measure of time to development of electrocardiographic changes indicative of ischemia and the subjective measure of time to onset of angina. Sixty-three male subjects (41-75 years) with well-documented coronary artery disease, who had exertional angina pectoris and ischemic ST-segment changes in their electrocardiograms, were studied. Results from three randomized, double-blind test visits (room air, low and high CO) were compared. The effect of CO exposure was determined from the percent difference in the end points obtained on exercise tests performed before and after a 1-hr exposure to room air or CO. A significant dose-response relationship was found for the individual differences in the time to ST end point and angina for the pre-versus postexposure exercise test at the ...

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND AND PURPOSE Human K2P3.1 (TASK1) channels represent potential targets for pharmacological management of atrial fibrillation. K2P channels control excitability by stabilizing membrane potential and by expediting repolarization. In the heart, inhibition of K2P currents by class III antiarrhythmic drugs results in action potential prolongation and suppression of electrical automaticity. Carvedilol exerts antiarrhythmic activity and suppresses atrial fibrillation following cardiac surgery or cardioversion. The objective of this study was to investigate acute effects of carvedilol on human K2P3.1 (hK2P3.1) channels. EXPERIMENTAL APPROACH Two-electrode voltage clamp and whole-cell patch clamp electrophysiology was used to record hK2P3.1 currents from Xenopus oocytes, Chinese hamster o...

Science.gov (United States)

Maternal exposure to ambient air pollution has increasingly been linked to adverse pregnancy outcomes. The evidence linking this exposure to congenital anomalies is still limited and controversial. This case-control study investigated the association between maternal exposure to ambient particulate matter with aerodynamic diameter less than 10 ?m (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxide, nitric oxide (NO), ozone (O(3)), and carbon monoxide (CO) and the occurrence of congenital heart disease in the population of Northeast England (1993-2003). Each case and control was assigned weekly average (weeks 3-8 of pregnancy) of pollutant levels measured by the closest monitor to the mother's residential postcode. Using exposure as both continuous and categorical variables, logistic regression models were constructed to quantify the adjusted odds ratios of exposure to air pollutants and the occurrence of each outcome group. We found exposure to CO and NO to be associated with ...

Energy Technology Data Exchange (ETDEWEB)

The 9/11 event in the U.S.A has increased international terror possibilities against nuclear facilities including nuclear power plants(NPPs). It is necessary to assess the performance of an existing physical protection system(PPS) at nuclear facilities based on such malevolent acts. A PPS is a complex configuration of detection, delay, and response elements. Several methods are available to analyze a PPS and evaluate its effectiveness. Sandia National Laboratory(SNL) in the USA was developed a System Analysis of Vulnerability to Intrusion (SAVI) computer code for this purpose. It is powerful software for evaluating the effectiveness of PPS against outsider threats. This study presents the performance assessment of the PPS at Wolsung NPP using SAVI code. First, the site-specific Adversary Sequence Diagrams(ASDs) of the PPS is constructed. It helps to understand the functions of the existing PPS composed of physical areas and Protection ...

Energy Technology Data Exchange (ETDEWEB)

The potential retinal hazard of dental visible-light photopolymerization units and the efficacy of protective lenses for reducing the potential hazards were assessed. The spectral radiance profiles of 11 visible-light photopolymerization units were measured; and the results were then weighted according to the American Conference of Governmental Industrial Hygienists (ACGIH) Blue Light and Thermal Hazard Functions. The results indicate that there are no thermal hazards to the retina even for the worst case condition. None of the blue-light hazard maximum permissible exposure times is short enough to be of concern unless the individual operator chooses to focus on the light source for an extended period. Those individuals who elect to stare at the light during curing procedures should consider the purchase of protective lenses. The special transmission profiles of 16 protective lenses were measured and new permissible ...

Energy Technology Data Exchange (ETDEWEB)

This paper reports on the protection of opening that are exposed to the environment in nuclear facilities which presents an almost overwhelming engineering challenge. Intakes and outflows must permit the passage of large volumes of air or water without impeding their flow, and they are often exposed to corrosive salt and chemicals. An intrusion detection sensor that is intended to protect these openings must be capable of operating reliably under environmentally harsh conditions, and at the same time either provide a physical delay barrier or attach to an existing barrier. A new fiber optic sensor technology has now been developed specifically for protecting environmentally exposed openings. This sensor uses a fiber optic cable embedded in a neoprene rubber frame which is reinforced with Kevlar threads or braided steel cable. The sensor is configured in a mesh pattern with openings sufficiently large to permit air or water ...

UK PubMed Central (United Kingdom)

Background:Several studies suggest transient ischemic attack (TIA) may be neuroprotective against ischemic stroke analogous to preinfarction angina's protection against...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundInterim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs). Data Monitoring Committees (DMCs) often...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The influence of applied potential on the erosion-corrosion (E-C) behavior of AISI321 stainless steel in 10% H{sub 2}SO{sub 4}+15% corundum sand (60 mesh) acidic slurry was investigated using a modified slurry pot apparatus. The surface morphologies of E-C specimens at various applied potentials were observed by scanning electron microscopy. The results showed that cathodic protection could significantly decrease E-C rate, and the cathodic protection efficiency could be 73.6%. The influence of applied anodic potentials on the E-C behaviors could be classified as the following three types: A. The E-C rate increased sharply in region I (a little more positive than free-corrosion potential); B. The E-C rate decreased significantly in region II (stable passive region), and the anodic protection efficiency could be 64.5%; C. The E-C rate increased again in region III (transpassive region) because of intergranular corrosion. The ...

UK PubMed Central (United Kingdom)

The t-butyldimethylsilyl group is shown to be an ideal protecting group for the 2T-hydroxyl function of ribonucleosides during the synthesis of ribonucleotides using any of nine commonly used condensing...Full Text Available

UK PubMed Central (United Kingdom)

Human exposure to perchlorate is commonplace because it is a contaminant of drinking water, certain foods, and breast milk. The U.S. Environmental Protection Agency (EPA) conducted a perchlorate risk...Full Text Available

Science.gov (United States)

May 18, 2001 ... Jeff Ashby, a Navy captain and veteran of ..... with the Department of Defense to acquire enough ..... Protection Handbook (Chapter 404). Each ..... x35416 or go to the website: http://www.ghg.net/cbr/jscas/ ...

Energy Technology Data Exchange (ETDEWEB)

For the laying of natural gas transport pipelines severe soil protection guidelines are in force in Switzerland. These guidelines influence, above all, the course of the construction in a substantial way. The Federal Office of Energy promulgated these guidelines in May 1993. They have provisional character and shall be reviewed based on the experiences with the in 1994 executed pipeline constructions. The protection of the soil from mechanical-physical loads, specially from soil erosion and compaction, is also a part of the modification of the federal legislation concerning environmental protection which is being dealt with at present by the federal parliament. (orig.) [Deutsch] Fuer die Verlegung von Erdgas-Transportleitungen gelten in der Schweiz strenge Bodenschutzrichtlinien, die vor allem den Bauablauf nachhaltig beeinflussen. Die Richtlinien wurden im Mai 1993 durch das Bundesamt fuer Energiewirtschaft erlassen. Sie ...