idiopathic epilepsy caused: Topics by WorldWideScience.org

A Fuzzy System for Helping Medical Diagnosis of Malformations of Cortical Development

Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully...Full Text Available

2010-07-01

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Teachers' perceptions of epilepsy.

Malformations of the cerebral cortex are recognized as a common cause of developmental delay, neurological deficits, mental retardation and epilepsy. Currently, the diagnosis of cerebral cortical...Full Text Available

2007-06-01

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Optical Coherence Tomography Findings in Idiopathic Macular Holes

A questionnaire survey undertaken among 142 schoolteachers in North Staffordshire revealed most of the respondents did not feel confident when teaching children who had epilepsy and a minority considered...Full Text Available

1992-12-01

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Idiopathic (primary) achalasia

Purpose. To describe the characteristics of idiopathic macular holes (MH) on optical coherence tomography (OCT) and correlate OCT with clinical assessment. Design....Full Text Available

2011-01-01

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Onset of epilepsy and menarche-Is there any relationship?

Idiopathic achalasia is a primary esophageal motor disorder characterized by esophageal aperistalsis and abnormal lower esophageal sphincter (LES) relaxation in response to deglutition. It is a rare...Full Text Available

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British Library Electronic Table of Contents (United Kingdom)

SummaryPurposeWomen with epilepsy have increased frequency of reproductive health problems compared to women without epilepsy. In puberty, reproductive hormonal changes during sexual maturation may affect epilepsy and induce the debut of seizures as indicated in some studies. On the other hand, epileptic activity affects sex hormone function, which may induce alterations in pubertal endocrine maturation and thereby menarche age. We wanted to investigate the relation between epilepsy and menarche age in a larger population of female epilepsy patients.MethodsA retrospective, questionnaire study of a cohort of 265 female outpatients from three Norwegian hospitals and 142 controls, aged 18-45 years was conducted. Parameters regarding epilepsy and reproductive health issues were registered. Per...

2006-01-01

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Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain

British Library Electronic Table of Contents (United Kingdom)

Summary Status epilepticus or other brain-damaging insults launch a cascade of events that may lead to the development of epilepsy. MRI techniques available today, including T2- and T1-weighted imaging, functional MRI, manganese enhanced MRI (MEMRI), arterial spin labeling (ASL), diffusion tensor imaging (DTI), and phase imaging, can detect not only damage caused by status epilepticus but also plastic changes in the brain that occur in response to damage. Optimal balance between damage and recovery processes is a key for planning possible treatments, and noninvasive imaging has the potential to greatly facilitate this process and to make personalized treatment plans possible.

2011-01-01

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Use of sodium chromate Cr/sub 51/ in diagnosing childhood idiopathic pulmonary hemosiderosis

The use of peritoneal venous shunting for intractable neonatal ascites: a short case series

The diagnosis of idiopathic pulmonary hemosiderosis (IPH) may be elusive. A 6-year-old boy had microcytic hypochromic anemia and a hemolytic component. Hemosiderin-laden macrophages were not found in the gastric aspirate. He had no pulmonary signs or symptoms. Extensive hematologic and roentgenologic investigations failed to reveal the cause of the anemia. Quantitative serial scintigraphic scanning showed significant (35%) pulmonary sequestration of autologous erythrocytes labeled with sodium chromate Cr51. The half-life of the RBCs was moderately decreased (half-life, 15 days; normal, 25 to 35 days). An open-lung biopsy spece Cr51. The half-life of the RBCs was moderately decreased (half-life, 15 days; normal, 25 to 35 days). An open-lung biopsy specimen confirmed the diagnosis of IPH. A diagnosis of IPH should be considered when children have iron deficiency anemia and pulmonary signs or symptoms. Organ sequestration studies may be helpful in ...

1984-08-01

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British Library Electronic Table of Contents (United Kingdom)

Introduction: Intractable ascites in neonates has a varied etiology; and often, the cause is idiopathic. The management usually consists of observation, diuretics, paracentesis, albumin replacements, and self correction. However, in some cases, the above treatment remains unsuccessful. Results: We present 2 cases of intractable ascites causing metabolic abnormalities, severe protein and immunoglobulin loss, and respiratory compromise. Although the use of peritoneovenous shunts for intractable ascites has been reported previously, our cases differ in both technique and patient size. Our first patient is an ex-28-week premature, 1.4-kg infant with intractable ascites for which a peritoneal drain was initially placed. After 3 weeks and putting out nearly 300 mL of ascitic fluid daily, we plac...

2011-01-01

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Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

Efficacy and safety of vigabatrin in the long-term treatment of refractory epilepsy

Objective:The aim of this study was to determine if there were focal cortical abnormalities in juvenile myoclonic epilepsy (JME) using neuropsychological investigations and MRI.Methods:Twenty-eight...Full Text Available

2011-01-04

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Manganese Induces IGF-1 and Cyclooxygenase-2 Gene Expressions in the Basal Hypothalamus during Prepubertal Female Development

1 The long term safety and efficacy of vigabatrin has been studied in 254 patients with refractory epilepsy (82% with partial seizures) in 23 different clinics in eight European countries....Full Text Available

1989-01-01

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British Library Electronic Table of Contents (United Kingdom)

Precocious puberty is a significant child health problem, especially in girls, because 95% of cases are idiopathic. Our earlier studies demonstrated that low-dose levels of manganese (Mn) caused precocious puberty via stimulating the secretion of luteinizing hormone-releasing hormone (LHRH). Because glial-neuronal communications are important for the activation of LHRH secretion at puberty, we investigated the effects of prepubertal Mn exposure on specific glial-derived puberty-related genes known to affect neuronal LHRH release. Animals were supplemented with MnCl2 (10 mg/kg) or saline by gastric gavage from day 12 until day 22 or day 29, then decapitated, and brains removed. The site of LHRH release is the medial basal hypothalamus (MBH), and tissues from this area were analyzed by real-...

2011-01-01

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Magnetic resonance imaging in childhood epilepsy

Pyridoxine dependent epilepsy and antiquitin deficiency Clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.

The suitability of MR imaging versus computerized tomography in observation of brain development disorders in children are compared. 13 refs.

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Ultrasonography and color Doppler of proximal gluteal enthesitis in juvenile idiopathic arthritis: a descriptive study

Antiquitin (ATQ) deficiency is the main cause of pyridoxine dependent epilepsy characterized by early onset epileptic encephalopathy responsive to large dosages of pyridoxine. Despite seizure control most patients have intellectual disability. Folinic acid responsive seizures (FARS) are genetically identical to ATQ deficiency. ATQ functions as an aldehyde dehydrogenase (ALDH7A1) in the lysine degradation pathway. Its deficiency results in accumulation of ?-aminoadipic semialdehyde (AASA), piperideine-6-carboxylate (P6C) and pipecolic acid, which serve as diagnostic markers in urine, plasma, and CSF. To interrupt seizures a dose of 100mg of pyridoxine-HCl is given intravenously, or orally/enterally with 30mg/kg/day. First administration may result in respiratory arrest in responders, and thus treatment should be performed with support of respiratory management. To make sure that late and masked response is not missed, treatment with oral/enteral ...

2011-05-24

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The use of etoricoxib to treat an idiopathic stabbing headache: a case report

BackgroundThe presence of enthesitis (insertional inflammation) in patients with juvenile idiopathic arthritis (JIA) is difficult to establish clinically and may influence classification...Full Text Available

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Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis

According to the International Headache Society, idiopathic stabbing headache (ISH), an indomethacin-responsive headache syndrome, is a paroxysmal disorder of short duration manifested as head pain...Full Text Available

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Idiopathic venous thromboembolism and thrombophilia

IntroductionPrevious observations suggest that active systemic juvenile idiopathic arthritis (sJIA) is associated with a prominent erythropoiesis gene-expression signature. The aim...Full Text Available

2010-01-01

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Combined photodynamic therapy and intravitreal bevacizumab for idiopathic polypoidal choroidal vasculopathy: one-year follow-up

During the past decade idiopathic venous thromboembolism has become a separate entity, a chronic illness which has required prolonged anticoagulation and other prevention strategies to avoid recurrences....Full Text Available

2011-02-15

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Abnormalities of GATA-1 in Megakaryocytes from Patients with Idiopathic Myelofibrosis

ObjectiveTo report the efficacy and safety of combined photodynamic therapy (PDT) and intravitreal bevacizumab (IVB) injection in the treatment of idiopathic polypoidal choroidal...Full Text Available

2010-01-01

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Prenatal exposure to ionizing radiation and subsequent development of seizures

The abnormal megakaryocytopoiesis associated with idiopathic myelofibrosis (IM) plays a role in its pathogenesis. Because mice with defective expression of transcription factor GATA-1 (GATA-1^low...Full Text Available

2005-09-01

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Assessment of chromosomal abnormalities in sperm of infertile men using sperm karyotyping and multicolour fluorescence in situ hybridization (FISH)

Seizures are a frequent sequela of impaired brain development and can be expected to affect more children with radiation-related brain damage than children without such damage. This report deals with the incidence and type of seizures among survivors prenatally exposed to the atomic bombing of Hiroshima and Nagasaki, and their association with specific stages of prenatal development at the time of irradiation. Fetal radiation dose was assumed to be equal to the dose to the maternal uterus. Seizures here include all references in the clinical record to seizure, epilepsy, or convulsion. Histories of seizures were obtained at biennial routine clinical examinations starting at about the age of 2 years. These clinical records were used to classify seizures as febrile or unprovoked (without precipitating cause). No seizures were ascertained among subjects exposed 0-7 weeks after fertilization at doses higher than 0.10 Gy. The incidence of seizures ...

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CDC - Men's Health A-Z - Workplace Safety and Health (Occupational...

Individuals with male factor infertility resulting from idiopathic oligo-, astheno- or teratozoospermia are frequently offered IVF in an attempt to increase their chances of having a child. A concern remains whether these infertile males have an elevated risk of transmitting chromosomal abnormalities to their offspring. Sperm chromosomal complements from these men were assayed using the human sperm/hamster oocyte fusion system and fluorescence in situ hybridization (FISH) on sperm nuclei. For each of 5 infertile patients, 100 sperm karyotypes were analyzed and multicolour FISH analysis was performed on a minimum of 10,000 sperm nuclei for each chromosome-specific DNA probe for chromosomes 1 (pUC1.77), 12 (D12Z3), X (XC) and Y (DYZ3). As a group, the infertile patients showed increased frequencies of both numerical ({chi}{sup 2}=17.26, {proportional_to} <0.001) and total abnormalities ({chi}{sup 2}=7.78, {proportional_to} <0.01) relative to control donors when ...

1994-09-01

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Distribution and threshold expression of the tRNA(Lys) mutation in skeletal muscle of patients with myoclonic epilepsy and ragged-red fibers (MERRF).

Curriculums The Epilepsy Foundation, in partnership with CDC, is conducting a national education and outreach program to educate and train law enforcement officers, police...

2011-09-03

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Pulmonary vein ablation for idiopathic atrial fibrillation: six month outcome of first procedure in 100 consecutive patients

We investigated the distribution and expression of mutant mtDNAs carrying the A-to-G mutation at position 8344 in the tRNA(Lys) gene in the skeletal muscle of four patients with myoclonus epilepsy and...Full Text Available

1992-12-01

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Wavelet-based Gaussian-mixture hidden Markov model for the detection of multistage seizure dynamics: A proof-of-concept study

Objectives: To report six month outcome in patients undergoing their first pulmonary vein ablation procedure for idiopathic atrial fibrillation (AF) at a “non-pioneering”...Full Text Available

2005-01-01

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Update on the Role of Substantia Nigra Pars Reticulata in the Regulation of Seizures

BackgroundEpilepsy is a common neurological disorder characterized by recurrent electrophysiological activities, known as seizures. Without the appropriate detection strategies,...Full Text Available

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Separating kindling and LTP: Lessons from studies of PKMzeta in developing and adult rats

The substantia nigra pars reticulata (SNR) represents an endogenous seizure suppressing system, which may be targeted to develop treatments for generalized or multifocal epilepsies. This review summarizes...Full Text Available

2006-05-01

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Partial (focal) seizure: MedlinePlus Medical Encyclopedia

The kindling model of temporal lobe epilepsy and the memory model of long-term potentiation (LTP) may have common underlying mechanisms. This is evident by the demonstration that certain signaling...Full Text Available

2009-04-10

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Novel Analogs and Stereoisomers of the Marine Toxin Neodysiherbaine with Specificity for Kainate Receptors

Academy of Neurology and the American Epilepsy Society. Neurology. 2007;69:1991-2007. Rubin DH, Kornblau DH, Conway Jr EE, et al. Neurologic Disorders. In: Marx, JA, ed. Rosen's...

2011-08-30

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Positional Stretching of the Coracohumeral Ligament on a Patient with Adhesive Capsulitis: A Case Report

Antagonists for kainate receptors (KARs), a family of glutamate-gated ion channels, are efficacious in a number of animal models of neuropathologies, including epilepsy, migraine pain, and anxiety....Full Text Available

2008-02-01

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Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis

Idiopathic frozen shoulder is a common medical diagnosis for patients seeking physical therapy. Radiographic and surgical evidence exists that describes the coracohumeral ligament (CHL) as a major contributor...Full Text Available

2009-01-01

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Increased wind-up to heat pain in women with a childhood history of functional abdominal pain

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor survival. The identification of therapeutic targets is essential to improving outcomes. Previous studies found that expression...Full Text Available

2011-03-31

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Disability and Psychologic Distress in Patients with Nonspecific and Specific Arm Pain

Idiopathic or functional abdominal pain (FAP) is common in school-age children and typically reflects a functional gastrointestinal disorder (FGID). FGIDs in adults have been distinguished by...Full Text Available

2011-04-01

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Pituitary disease in childhood: utility of magnetic resonance; Patologia hipofisaria en la edad pediatrica: unidad de la resonance magnetica

Psychological illness influences the experience and expression of pain and disability. We tested three null hypotheses: (1) patients with nonspecific pain (medically unexplained and idiopathic) and...Full Text Available

2008-11-01

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Disorders of brain development and phakomatosis

To assess the utility of magnetic resonance (MR) imaging in the study of pediatric patients with clinical suspicion of pituitary disease. We studied 18 patients aged 7 to 18 years.Fifteen had hormonal disturbances, two presented amenorrhea and 1 complained of headache, fever and symptoms of polyuria and polydipsia. All the patients were examined using a Siemens SP 42 1-Tesla MRI scanner. Sagittal and coronal T1-weighted spin-echo images were obtained; in addition T2-weighted spin-echo or fast spin-echo imaging was performed in ten cases and intravenous gadolinium was administered in nine. We found 9 patients with hypothalamic-pituitary dysgenesis, 2 with germinoma, 2 cases of pituitary hemosiderosis in patients with thalassemia, 2 cases of microadenoma, one abscess, one case of idiopathic central diabetes insipidus and one of Langerhans cell histiocytosis. MR enabled us to assess pituitary structural alterations in children with hypothalamic-pituitary hormone ...

2000-07-01

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Pirfenidone in idiopathic pulmonary fibrosis: the CAPACITY program

Full text: Disorders of brain development and phakomatosis are resulting from disturbed embryonic-foetal development One third of all major embryological anomalies involve CNS, and over 2000 different anomalies have been described. Anomalies of the brain often cause foetal and neonatal death, and mental and physical retardation in pediatric group. The majority of disorders of brain development and phakomatosis are idiopathic, and most of them are not hereditary or familial. Ultrasonography plays the important role in screening foetal and neonatal brain, but after closure of fontanels it is difficult to find the acoustic window. CT has limited contrast resolution, and disadvantage exposing infant to ionizing radiation. It is helpful to demonstrate the presence of calcifications. MR imaging has proved to be a diagnostic tool of major importance in children with disorders of brain development and phakomatosis. The excellent grey/white matter ...

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British Library Electronic Table of Contents (United Kingdom)

Idiopathic pulmonary fibrosis is the most lethal form of diffuse lung fibrosis, killing approximately half of those affected within 2-3 years of diagnosis. Until recently, no therapies had been shown to have an impact on disease progression. The Clinical Studies Assessing Pirfenidone (Esbriet) in IPF: Research of Efficacy and Safety Outcomes (CAPACITY) program comprised two almost identical double-blind placebo-controlled studies assessing the effects of pirfenidone on change in forced vital capacity, the primary end point, over a 72-week period. One of these studies was positive, matching in magnitude the benefit seen in two previous positive Japanese studies. The other study did not meet its primary end point but positive trends were consistent in this and a number of secondary end point...

2011-01-01

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Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy(SUDEP)

Preoperative factors predictive of postoperative decimal visual acuity ? 1.0 following surgical treatment for idiopathic epiretinal membrane

Mice lacking Kv1.1 Shaker-like potassium channels encoded by the Kcna1 gene exhibit severe seizures and die prematurely. The channel is widely expressed in...Full Text Available

2010-04-14

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An evaluation of the utility of routine laboratory monitoring of juvenile idiopathic arthritis (JIA) patients using non-steroidal anti-inflammatory drugs (NSAIDs): a retrospective review

Purpose:To report the preoperative best-corrected visual acuity (BCVA) and foveal thickness (FT) values that lead to a postoperative decimal BCVA of ≥1.0 after surgical removal...Full Text Available

2011-01-01

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Veterinary care of the Belgian Malinois military working dog.

BackgroundNo consensus evidence-based guidelines for the routine laboratory monitoring of children with JIA receiving non-steroidal anti-inflammatory drugs (NSAIDs) exist. The purpose...Full Text Available

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Idiopathic renal hematuria in a military working dog.

The Belgian Malinois dog was introduced into the Department of Defense Military Working Dog Program in 1984. All dogs are purchased in Europe and have adapted well to the rigorous training requirements of the program. Most veterinary problems seen in this breed are related to kennel confinement and include traumatic dental disease, tail lesions, a variety of dermatologic conditions, and an inability to gain weight. Epilepsy is a breed problem and has been seen in this population, as has gastric dilatation/volvulus. Both elbow and hip dysplasia exist in the Malinois breed. PMID:1900116

1991-01-01

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Incidence of lesions as described by MRI in focal epilepsy of frontal and temporal onset; Inzidenz kernspintomographisch erfassbarer Laesionen bei der Abklaerung fokaler Epilepsien frontalen und temporalen Ursprunges

A 1.5-year-old male Belgian Malinosis Military Working Dog presented with a 1-month history of intermittent hematuria. Diagnostic ultrasound and contrast radiography demonstrated large blood clots in the urinary bladder and a filling defect in the right renal pelvis. At surgery, clotted blood was present in the right ureter and bladder. Following right nephrectomy, the dog returned to training. One month later, elevations in urea nitrogen and creatinine were noted. Hematuria recurred at 3 months and the dog was found dead in its kennel. Necropsy showed a blood-filled left renal pelvis and ureter. PMID:1454185

1992-10-01

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Kundur [Benincasa hispida (Thunb.) Cogn.]: A potential source for valuable nutrients and functional foods

Aim: Today, MRI is an integral part of the presurgical evaluation of patients suffering from partial epilepsy. These patients frequently show focal morphological abnormalities with potential epileptogenic character and surgical resection of these lesions is associated with superior postsurgical outcome as to seizure frequency. Apart from easily detectable defects, such as post-traumatic lesions or cerebral infarction, as wide variety of mainly small abnormalities can be detected using MRI. Methods: In this study, 484 patients suffering from partial epilepsy of temporal or frontal onset were evaluated for the incidence of different lesions in this population. Results: All lesions found were included without evaluating their potential epileptogenicity, which remains to be proven using other procedures (EEG, SPECT, PET, etc.). Involvement of the hippocampal formation was a major finding in temporal lobe epilepsy, which could ...

1997-09-01

45

British Library Electronic Table of Contents (United Kingdom)

Kundur [Benincasa hispida (Thunb.) Cogn.], a member of the family Cucurbitaceae, is one of the famous crops that are grown primarily for its fruits and usually recognized with its nutritional and medicinal properties especially in Asian countries. Kundur fruit has been valued as a nutritious vegetable as it provides a good source for natural sugars, amino acids, organic acids, mineral elements and vitamins. A number of medicinal properties such as anti-diarrheal, anti-obesity, anti-ulcer, and antioxidant and diuretic have been ascribed to this fruit of high economic value. As a rich source of functionally important bioactives and therapeutics such as triterpenes, phenolics, sterols, and glycosides, the fruit has been widely used for the treatment of epilepsy, ulcer, and other nervous disor...

2011-01-01

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Development and validation of a reference measurement procedure for certification of phenytoin, phenobarbital, lamotrigine, and topiramate in human serum using isotope-dilution liquid chromatography/tandem mass spectrometry

British Library Electronic Table of Contents (United Kingdom)

Phenytoin (PHT), phenobarbital (PHB), lamotrigine (LTG), and topiramate (TPM) are some of the most widely used antiepileptic drugs (AEDs). Monitoring of their concentrations in serum is important for the treatment of epilepsy. A reference measurement procedure (RMP) for certification of PHT, PHB, LTG, and TPM in serum has been developed and critically evaluated. Isotopically labeled compounds of PHT, PHB, LTG, and TPM are used as internal standards for the four AEDs. The four drugs and their respective labeled internal standards are simultaneously extracted from serum using solid-phase extraction prior to reversed-phase liquid chromatography?tandem mass spectrometry (LC-MS/MS). Chromatographic separation was performed using a C18 column. Electrospray ionization (ESI) in the positive ion mo...

2011-01-01

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[Pulmonary vascular manifestations in hereditary hemorrhagic telangiectasia].

Treatment of asymptomatic internal resorption of a maxillary premolar tooth in a military working dog.

Hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) is a genetic disorder with autosomal dominance, variable penetrance, and an estimated prevalence of 1/10,000 inhabitants in France. Diagnosis is based on clinical criteria including epistaxis, telangiectasia, visceral manifestations, and familial occurrence. Pulmonary arteriovenous malformations, present in 15-33% of patients, are its primary visceral complications. The disease may be revealed by infectious and ischemic neurological manifestations due to paradoxical embolism. The high frequency of neurologic complications even in asymptomatic patients justifies systematic screening for pulmonary arteriovenous malformations. Treatment of these malformations is based on percutaneous transcatheter coil embolization of the feeding artery. Pulmonary arterial hypertension is rare in this disease. It may be due to systemic arteriovenous shunting in the liver, which increases cardiac output, or be similar to ...

2005-11-01

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Mucosal Inflammation in Spondylarthritides: Past, Present, and Future

An asymptomatic pink discoloration of a maxillary right fourth premolar tooth was discovered during a routine oral examination on a 9 year-old Belgian Malinois dog. A radiolucent lesion was seen in the pulpal chamber on radiographic examination. The lesion had perforated the mesiobuccal root of the tooth. The primary differential diagnosis was idiopathic internal resorption. The tooth was treated by partial resection (removal of the mesiobuccal root and associated crown). A vital pulpotomy and amalgam restoration was performed on the remaining tooth structure. A follow-up 1 year later demonstrated a successful treatment outcome. The animal was asymptomatic and able to perform military duties. Clinical and radiographic signs of healing were evident and the tooth was functional. PMID:10518874

1998-12-01

49

British Library Electronic Table of Contents (United Kingdom)

Spondylarthritides (SpA) and inflammatory bowel disease (IBD) are idiopathic, chronic inflammatory disorders. Although they are very distinct and well-defined entities, there is clinical and genetic evidence supporting some degree of overlap between the pathogenesis of the two. Subclinical gut inflammation is present in up to two thirds of all SpA patients and can evolve into IBD. This subclinical gut inflammation has been shown to be strongly associated with joint inflammation, providing a clue for a common pathophysiologic background. Despite extensive research progress in the field over the past few years, many questions remain unanswered. In this paper, we focus on the clinical, genetic, and pathophysiologic overlap of SpA and IBD. Furthermore, we discuss some of the targets that may i...

2011-01-01

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One-year follow-up of the effects of sildenafil on pulmonary arterial hypertension and veno-occlusive disease

Scientific Electronic Library Online (English)

Abstract in english We hypothesized that chronic oral administration of the phosphodiesterase-5 inhibitor sildenafil could improve the exercise capacity and pulmonary hemodynamics in patients with pulmonary arterial hypertension (PAH) on the basis of previous short-term studies. We tested this hypothesis in 14 subjects with PAH, including seven patients with the idiopathic form and seven patients with atrial septal defects, but no other congenital heart abnormalities. Patients were subjected (more) to a 6-min walk test and dyspnea was graded according to the Borg scale. Pulmonary flow and pressures were measured by Doppler echocardiography. Patients were given sildenafil, 75 mg orally three times a day, and followed up for 1 year. Sildenafil therapy resulted in the following changes: increase in the 6-min walk distance from a median value of 387 m (range 0 to 484 m) to 462 m (range 408 to 588 m; P

2005-02-01

51

Citrat og nyresten

DEFF Research Database (Denmark)

Citrate is an important naturally occurring inhibitor of calcium stone formation in urine. Urinary citrate excretion was examined in 43 consecutive patients with recurrent idiopathic calcium nephrolithiasis and in 50 normal controls by a specific enzymatic technique. Hypocitraturia (<1.6 mmol/24h) was found in 14 (33%) stone formers compared to 6 (12%) normal controls (p = 0.03). Citrate excretion expressed as citrate-creatinine ratio in 24 hour urine samples was significantly lower in the stone formers than in the healthy controls (p = 0.03), and significantly lower in healthy men, compared to healthy females (p = 0.006). There was a great variability in urinary citrate levels in both groups, and a considerable overlap in the urinary citrate excretion between normal subjects and stone formers. Factors other than urinary citrate excretion must therefore be of importance in the pathophysiology of calcium stone formation. Citrate-calcium ratio in urine proved to ...

1993-01-01

52

Causes of Fever in the ICU - A Prospective, Cohort Study

A Case of Osteomalacia Caused by Severe Vitamin D Deficiency

Full Text Available

2008-06-01

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Regulation of Cancer-Causing Food Additives-Time for a ...

Full Text Available

2007-02-01

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Lesion of the esophagus by tetracycline medication

... Accession Number : ADA145145. Title : Regulation of Cancer-Causing Food Additives-Time for a Change? Corporate Author ...

1981-12-11

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The neurological mouse mutations jittery and hesitant are allelic and map to the region of mouse chromosome 10 homologous to 19p13.3

One case of esophagitis caused by oral medication of Tetracycline is reported. The cause and factors predisposing to this uncommon complication of oral medication are discussed.

1984-06-01

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High-resolution "1H magnetic resonance spectroscopy imaging at 1.5 and 3 Tesla of the human brain: development of techniques and applications for patients with primary brain tumors and multiple sclerosis

Jittery (ji) is a recessive mouse mutation on Chromosome 10 characterized by progressive ataxic gait, dystonic movements, spontaneus seizures, and death by dehydration/starvation before fertility. Recently, a viable neurological recessive mutation, hesitant, was discovered. It is characterized by hesitant, uncoordinated movements, exaggerated stepping of the hind limbs, and reduced fertility in males. In a complementation test and by genetic mapping we have shown here that hesitant and jittery are allelic. Using several large intersubspecific backcrosses and intercrosses we have genetically mapped ji near the marker Amh and microsatellite markers D10Mit7, D10Mit21, and D10Mit23. The linked region of mouse Chromosome 10 is homologous to human 19p13.3, to which several human ataxia loci have recently been mapped. By excluding genes that map to human 21q22.3 (Pfkl) and 12q23 (Nfyb), we conclude that jittery is not likely to be a genetic mouse model for human Unverricht-Lundborg ...

1996-08-01

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Assessment of bone formation and bone resorption in osteoporosis: a comparison between tetracycline-based iliac histomorphometry and whole body /sup 85/Sr kinetics

The aim of this work was to develop several strategies and software-packages for the evaluation of in-vivo-data of the human brain, which were acquired with high-resolution 1H-MRSI at 1.5 and 3 T. Several studies involving phantoms, volunteers and patients were performed. Quality assurance studies were conducted in order to evaluate the reproducibility of the applied MR-techniques at both field strengths. A qualitative comparison-study between MRSI-data from a 1.5 T clinical MR-scanner and a 3 T research MR-scanner showed the advantages of the more advanced MRSI sequences and higher field strength (3 T). A study involving patients with primary brain tumours (gliomas) was performed in cooperation with the Department of Neurosurgery (University of Erlangen-Nuremberg). The methods developed in the course of this study, such as the integration of MRS-data into a stereotactic-system, the segmentation of metabolic maps and the correlation with histopathological findings represent a package ...

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The Meaning of Cause and Prevent: The Role of Causal Mechanism

Bone formation and resorption have been measured in patients with idiopathic osteoporosis by histomorphometry of 7.5-mm trephine biopsies and in the whole body by 85Sr radiotracer methodology and calcium balances. The studies were synchronized and most were preceded by double in vivo tetracycline labeling. Correlations between histological and kinetic bone formation indices were better when better when based on the extent of double tetracycline labels than on measurements of osteoid by visible light microscopy. Correction of the kinetic data for long-term exchange, using 5 months' serial whole body counting of retained 85Sr, improved the fit of the kinetic to the histological data. A statistical analysis of the measurement uncertainties showed that the residual scatter in the best correlations (between exchange-corrected bone formation rates and double-labeled osteoid surface indices) could be attributed to measurement imprecision alone. The ...

1987-12-01

59

British Library Electronic Table of Contents (United Kingdom)

How do people understand questions about cause and prevent? Some theories propose that people affirm that A causes B if A's occurrence makes a difference to B's occurrence in one way or another. Other theories propose that A causes B if some quantity or symbol gets passed in some way from A to B. The aim of our studies is to compare these theories' ability to explain judgements of causation and prevention. We describe six experiments that compare judgements for causal paths that involve a mechanism, i.e. a continuous process of transmission or exchange from cause to effect, against paths that involve no mechanism yet a change in the cause nevertheless brings about a change in the effect. Our results show that people prefer to attribute cause when a mechanism links cause to effect. In contr...

2011-01-01

60

Primary lymphoma of the brain: MedlinePlus Medical Encyclopedia

Pneumomediastinum as a complication of emphysematous cholecystitis: Case report

brain Printer-friendly version Email this page to a friend Share Primary lymphoma of the brain is cancer of the lymph cells that starts in the brain. Causes The cause of primary...

2011-10-13

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Duodenal ileus caused by a calf feeding nipple in a cow

BackgroundEmphysematous cholecystitis is a variant of acute cholecystitis which is generally caused by gas-forming organisms. Emphysematous cholecystitis may cause gas spreading...Full Text Available

62

Cutaneous Scarring: A Clinical Review

BackgroundThe aim of this report was to describe duodenal obstruction caused by a rubber foreign body in a cow.Case PresentationThe clinical, biochemical...Full Text Available

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Bladder outlet obstruction in male cystinuria mice

Cutaneous scarring can cause patients symptoms ranging from the psychological to physical pain. Although the process of normal scarring is well described the ultimate cause of pathological scarring...Full Text Available

2009-01-01

64

Pulsations in the compression chamber, a potential cause of damage?; Pulsationen im Verdichtungsraum - eine potentielle Schadensursache?

BackgroundCystinuria is the most common inherited cause of urinary tract stones in children. It can lead to obstructive uropathy, which is a major cause of renal...Full Text Available

2010-03-01

65

Growth Inhibition of Sclerotium Cepivorum Causing Allium White Rot by Serratia plymuthica Producing Chitinase

No abstract prepared.

2005-05-01

66

Prenatal Care Visits

Medline Plus

... a test for HIV, the virus that causes AIDS. Do a Pap smear to check for cervical ...

67

Efficacy of Fluopicolide against Phytophthora capsici Causing Pepper Phytophthora Blight

Full Text Available

2003-02-01

68

Efficacy Study of a New Antimicrobial Wound Dressing to Treat Wounds Caused by Curettage and Electrodesiccation

Full Text Available

2010-12-01

69

Effect of Chitosan Solution on the Inhibition of Pseudomonas fluorescens Causing Bacterial Head Rot of Broccoli

Acute Wounds

2011-03-04

70

Assessment of Priority Order Using the Chemical to Cause to Generate Occupational Diseases and Classification by GHS

Full Text Available

2010-06-01

71

The root cause analysis of 9DVN002ZV fan failure in Daya Bay Nuclear Power Station

Full Text Available

2010-06-01

72

aHUS caused by complement dysregulation: new therapies on the horizon

Extensive investigations and detailed analysis of the failure reason of 9DVN002ZV fan in Daya Bay Nuclear Power Station showed that the fan destroy was caused by the failure of non-drive end bear. The direct cause of this bearing' failure was its improper assembly caused by improper maintenance procedure, and the root cause was too small internal radial clearance after mounting. The factor affecting bearing internal radial clearance, the relationship between clearance and operating life time and fan failure process were discussed. (authors)

2005-09-01

73

The Importance of Poisoning vs. Road Traffic Injuries as a Cause of Death in Rural Sri Lanka

Atypical hemolytic uremic syndrome (aHUS) is a heterogeneous disease that is caused by defective complement regulation in over 50% of cases. Mutations have been identified in genes encoding both complement...Full Text Available

2011-01-01

74

Sugarcane Rust Inoculations

BackgroundRoad traffic crashes are considered by the WHO to be the most important global cause of death from injury. However, this may not be true for large areas of rural Asia where...Full Text Available

75

Smoking and All-Cause Mortality among a Cohort of Urban Transit Operators

Sugarcane rusts, brown (caused by Puccinia melanocephala) and orange (caused by P. kuehnii), are agronomically important diseases in Florida. Cultivar resistance is the best means of managing these diseases. Unfortunately, natural infection of brown rust is not always efficient in determining resist...

76

Protective effects of sparfloxacin in experimental pneumonia caused by Chlamydia pneumoniae in leukopenic mice.

This study assesses the contribution of smoking to all-cause mortality among a primarily minority cohort of urban transit operators. Survey and medical exam data, obtained from 1,785 workers (61% African...Full Text Available

2008-09-01

77

Prevalence and causes of blindness and visual impairment in Muyuka: a rural health district in South West Province, Cameroon

The in vivo antichlamydial activities of sparfloxacin and reference drugs were examined in a experimental model of pneumonia caused by Chlamydia pneumoniae in leukopenic mice; their in vitro activities...Full Text Available

1994-08-01

78

Phaeoisaria clematidis as a Cause of Keratomycosis

AimTo estimate the prevalence and causes of blindness and visual impairment in the population aged 40 years and over in Muyuka, a rural district in the South West Province...Full Text Available

2006-05-01

79

Persistence in herpes simplex virus infections.

We report the first case of human infection by Phaeoisaria clematidis. This fungus caused a corneal ulcer in a Brazilian man who had previously suffered an eye injury. Diagnosis was...Full Text Available

2000-06-01

80

Partial Purification and Characterization of Biological Effects of a Lipid Toxin Produced by Mycobacterium ulcerans

Diseases of man caused by the virus of herpes simplex fall into two broad categories. The primary disease occurs only once in any individual's life and is caused by transmission of virus from an already...Full Text Available

1978-09-01

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81

Knockdown of Bicaudal C in Zebrafish (Danio rerio) Causes Cystic Kidneys: A Nonmammalian Model of Polycystic Kidney Disease

Organisms in the genus Mycobacterium cause a variety of human diseases. One member of the genus, M. ulcerans, causes a necrotizing skin disease called Buruli ulcer....Full Text Available

1998-02-01

82

Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction

Polycystic kidney disease (PKD) is one of the leading causes of end-stage renal disease in humans and is characterized by progressive cyst formation, renal enlargement, and abnormal tubular development....Full Text Available

2010-04-01

83

Giant vesical diverticulum: A rare cause of defecation disturbance

BackgroundMethamphetamine (METH), an addictive psycho-stimulant drug with euphoric effect is known to cause neurotoxicity due to oxidative stress, dopamine accumulation and glial...Full Text Available

84

From Attachment to Damage: Defined Genes of Candida albicans Mediate Adhesion, Invasion and Damage during Interaction with Oral Epithelial Cells

Vesical diverticula frequently result from bladder outlet obstructions. However, giant vesical diverticula which cause acute abdomen or intestinal obstruction are very rare. Our review of the English...Full Text Available

2009-08-21

85

Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease

Candida albicans frequently causes superficial infections by invading and damaging epithelial cells, but may also cause systemic infections by...Full Text Available

86

Effect before Cause: Supramodal Recalibration of Sensorimotor Timing

BackgroundAlzheimer's Disease (AD) is the most common neurodegenerative disease and the leading cause of dementia among senile subjects. It has been proposed that AD can be caused...Full Text Available

87

Diethyl thiourea as a cause of dermatitis in a car factory

BackgroundOur motor actions normally generate sensory events, but how do we know which events were self generated and which have external causes? Here we use temporal adaptation...Full Text Available

88

Diagnostic Dilemma in an Unusual Case of Common Bile Duct Obstruction

White, W. G., and Vickers, H. R. (1970).Brit. J. industr. Med.,27, 167-169. Diethyl thiourea as a cause of dermatitis in a car factory. Fifteen...Full Text Available

1970-04-01

89

Construction and Characterization of Genetically Defined aro omp Mutants of Enterotoxigenic Escherichia coli and Preliminary Studies of Safety and Immunogenicity in Humans

Biliary obstructions are rarely caused by a foreign body and have received sparse attention. We present an unusual case with pruritis and abdominal pain caused by impacted full length surgical gauze...Full Text Available

2011-06-01

90

Causes and 3-year-incidence of blindness in Jing-An District, Shanghai, China 2001-2009

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in travelers to countries where the disease is endemic and causes a major disease burden in the indigenous population,...Full Text Available

2001-08-01

91

Aspirin Treatment of Mice Infected with Trypanosoma cruzi and Implications for the Pathogenesis of Chagas Disease

BackgroundRegistered data can provide valuable information regarding blindness. The purpose of this study was to evaluate the main causes and 3-year incidence of registered blindness...Full Text Available

92

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

Chagas disease, caused by infection with Trypanosoma cruzi, is an important cause of cardiovascular disease. It is increasingly clear that parasite-derived prostaglandins potently modulate...Full Text Available

93

The protein truncation caused by fusion of PEP-1 peptide and protective roles of transduced PEP-1-MsrA in skin cells

Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the second most common cause of early-onset dementia. Mutations in the progranulin gene are a major cause of familial...Full Text Available

2011-03-15

94

Photopolymer Holographic Optical Elements

Full Text Available

2011-04-01

95

PRODUCT NAME CAUSTIC SODA (RHEOCHEM)

... The re-emergence of holographic photopolymers in the 1980's created an interest as to the cause of holographic notch filter instability. ...

1987-06-01

96

Wastenet

has the potential to cause severe acute and chronic health effects with over exposure.Use safe work

97

Comparison of Microbial Fungicides in Antagonistic Activities Related to the Biological Control of Phytophthora Blight in Chili Pepper Caused by Phytophthora capsici

Active Shimmy Control System

Full Text Available

2010-12-01

98

Safety analysis and license of rod drop time issue at Daya Bay Nuclear Power Plant

... Both effects are undoubtedly caused by the ahaping of the spool valve flow characteristics The linear region of response corresponds to ...

1975-12-01

99

CP-Sugarcane Research in Florida: Past Achievements and Future Challenges

The rod drop time event of the Daya Bay Nuclear Power Plant is caused by the malfunction of the guide tube developed by Framatome. Three temporary solutions were implemented successively and the long term solution was found in the process of searching for the root cause. The different solutions and the root cause are introduced. The safety analysis and license of the solutions are mainly discussed. Experiences and lessons are drawn by summarizing the important items related to nuclear safety.

100

A Case of Severe Hemorrhagic Cystitis Caused by Melphalan with Successful Bladder Preservation by Ligation of Bilateral Internal Iliac Arteries

Sugarcane orange rust is an economically important disease in Florida and has caused yield losses in the major cultivar, CP 80-1743 since it was introduced in 2007. Orange rust has caused susceptible cultivars to be discarded from the CP-cultivar development program and is also causing yield losses....

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101

Dendroaspis natriuretic peptide is the most potent natriuretic peptide to cause relaxation of lower esophageal sphincter

Hemorrhagic cystitis is a disorder which causes bleeding from diffusely inflammatory bladder mucosa. Here we present a case of severe hemorrhagic cystitis caused by melphalan. A 70-year-old man with...Full Text Available

2010-01-01

102

British Library Electronic Table of Contents (United Kingdom)

Atrial natriuretic peptide (ANP) causes relaxation in the opossum lower esophageal sphincter. The effects of dendroaspis natriuretic peptide (DNP) and other natriuretic peptides in the lower esophageal sphincter were not known. We measured the relaxation of transverse strips from the guinea pig lower esophageal sphincter caused by DNP, ANP, brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and a natriuretic peptide receptor-C agonist des[Gln^1^8, Ser^1^9, Gly^2^0, Leu^2^1, Gly^2^2]ANP(4-23) amide (cANF(4-23)) in vitro. In resting strips of the guinea pig lower esophageal sphincter DNP and BNP caused marked relaxations. Furthermore, in both sarafotoxin S6c and carbachol-contracted lower esophageal sphincter strips, DNP caused marked and BNP caused moderate, concentration-de...

2011-01-01

103

Microcantilever detector for explosives

Methods and apparatus for detecting the presence of explosives by analyzing a vapor sample from the suspect vicinity utilize at least one microcantilever. Explosive gas molecules which have been adsorbed onto the microcantilever are subsequently heated to cause combustion. Heat, along with momentum transfer from combustion, causes bending and a transient resonance response of the microcantilever which may be detected by a laser diode which is focused on the microcantilever and a photodetector which detects deflection of the reflected laser beam caused by heat-induced deflection and resonance response of the microcantilever. 2 figs.

1999-06-29

104

Ignition system

Displacement of a railway bridge caused by coal mining

This patent describes an ignition system of an internal combustion engine which consists of: a permanent magnet supported by a rotary member of the engine adapted to rotate in synchronism with a rotary shaft of the engine; a generating coil for generating an electromotive force to produce an electric current as the permanent magnet acts on the generating coil during the rotation of the rotary member; an ignition capacitor charged by the electric current generated by the generating coil; a thyristor caused to turn on by a counter electromotive force generated by the generating coil to thereby cause the ignition capacitor to begin to discharge; and an ignition coil generating a high voltage as the ignition capacitor begins to discharge, to cause a spark discharge to take place in an ignition plug of the internal combustion engine.

1986-09-16

105

Causes of denting. Volume 5. Contaminant threshold tests. Final report

Evaluates displacement of a railway bridge element of the Walbrzych-Klodzko railway line. The bridge, consisting of three truss sections supported by two pillars made of reinforced concrete, was influenced by longwall mining. Longwalls were perpendicular to the bridge axis. Three coal seams situated in the bridge safety pillar were 550 cm thick. Ground subsidence after seam extraction was 400 cm. Ground subsidence did not cause truss section deformation, nor did it cause additional stresses in truss bridge construction. 2 refs.

1988-01-01

106

Warning Signs and Risk Factors

Steam generators in PWR plants have been subject to denting corrosion as a result of nonprotective magnetite forming on the carbon steel support plate causing the voluminous corrosion product that eventually crimps (dents) the heat transfer tube at the support plate interface. This project was designed to determine the causes of denting and the usefulness of water chemistry changes meant to arrest denting. This volume of the final report describes laboratory research on the correlation of water chemistry, superheat, and oxygen ingress with denting in steam generators.

1983-12-01

107

Medline Plus

[music] Narrator: New treatments can limit the disability caused by a stroke, but you need to know the signs and act in time. Here are the signs to ...

108

Violence in a community emergency room.

Treatment of persons exposed in radiation accidents or nuclear explosions. Omhaendertagande av skadade vid radiakolyckor och kaernvapenexplosioner

Violence in both community and county hospitals in the USA is increasing. It caused significant physical, emotional and economic hardship to many emergency department employees. We describe an incident...Full Text Available

1989-12-01

109

The sites and topology of mitochondrial superoxide production

The report gives general principles of treatment and care of casualties caused by radiation accidents or nuclear explosions.

1991-01-01

110

The Prevalence of low back pain in Africa: a systematic review

Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide...Full Text Available

2010-08-01

111

The International Tethered Cord Partnership: Beginnings, process, and status

BackgroundLow back pain (LBP) is the most prevalent musculoskeletal condition and one the most common causes of disability in the developed nations. Anecdotally, there is a general...Full Text Available

112

Technical Report Series on the Boreal Ecosystem-Atmosphere Study ...

Background:Spina bifida presents a significant cause of childhood morbidity in lower- and middle-income nations. Unfortunately, there is a paucity of literature examining...Full Text Available

113

Studies of the action of hypoglycin-a, a hypoglycaemic substance

A floating boardwalk was constructed from the shore to ...... Irrespective of whether we could tie the outlier to a cause, a simple linear interpolation was ...

114

Streptococcus agalactiae mastitis: a review.

Some biological effects of hypoglycin-A, a compound isolated from the fruit of Blighia sapida, have been investigated. Administration of this compound to animals caused drowsiness...Full Text Available

1958-06-01

115

Spread dynamics of invasive species

Streptococcus agalactiae continues to be a major cause of subclinical mastitis in dairy cattle and a source of economic loss for the industry. Veterinarians are often asked to provide information on...Full Text Available

1997-07-01

116

Spatial and Temporal Variability of Column Integrated Aerosol - NASA

Species invasions are a principal component of global change, causing large losses in biodiversity as well as economic damage. Invasion theory attempts to understand and predict invasion success and...Full Text Available

2006-01-10

117

Sinonasal malignancies: a 10-year review in a tertiary health institution.

the southern Arabian Gulf region left its signature on the heterogeneous aerosol .... Arabian Gulf region, since large differences in ? may be caused by ...

118

Sinonasal malignancy is a cause of otorhinolaryngologic morbidity and mortality in West Africa. However, there is a dearth of information in the literature on its clinicopathologic presentation in West...Full Text Available

2007-12-01

119

Shoulder pain

Sacral haemangioma as a cause of coccydynia

IntroductionShoulder pain covers a wide range of problems and affects up to 20% of the population. It is not a specific diagnosis. Shoulder pain can be caused by problems with the...Full Text Available

120

Root Cause Analysis, Tank Fire Problem, M1A1 Main Battle ...

We report a 55-year-old woman with coccydynia due to a sacral mass. The histological diagnosis was haemangioma. The MRI findings and the unusual location of this lesion are discussed. (orig.)

1998-08-01

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121

Review of Cost-Effectiveness Analysis of Medical Treatment For Myocardial Infarction

... ammunition is stored. Combustible cartridge cases could absorb moisture, swell, and not chamber properly. Additionally, moisture ...

1989-02-01

122

Objectives:Myocardial infarction (MI) is a leading cause of death in both the industrialized and developing countries globally. The economic evaluation of MI is undertaken...Full Text Available

2011-04-01

123

Reversing B cell aging

Age-related alterations in the cellular composition of the B lineage are a major cause of the poor antibody response to vaccination and to infectious agents among the elderly population. The mechanisms...Full Text Available

124

Premature labour

Plasmid-Determined Copper Resistance in Pseudomonas syringae from Impatiens

Prematurity is by far the commonest cause of neonatal morbidity and mortality. The management of premature labour is empirical because little is understood about the mechanism of labour. Effective...Full Text Available

1976-04-17

125

Place matters: multilevel investigation of HIV distribution in Tanzania

A strain of Pseudomonas syringae was recently identified as the cause of a new foliar blight of impatiens. The bacterium was resistant to copper compounds, which are used on a variety...Full Text Available

1990-01-01

126

Parenchyma-sparing pancreatectomies for benign or border-line tumors of the pancreas

ObjectiveTo examine the extent to which the regional and neighborhood distribution of HIV in Tanzania is caused by the differential distribution of individual correlates...Full Text Available

2008-03-30

127

Oxidative Stress Disrupts Oligodendrocyte Maturation

Standard pancreatic resections, such as pancreaticoduodenectomy, distal pancreatectomy, or total pancreatectomy, result in an important loss of normal pancreatic parenchyma and may cause impairment...Full Text Available

2010-06-15

128

Oxidative Damage and the Prevention of Age-Related Cataracts

Periventricular white matter injury (PWMI), is the leading cause of chronic neurologic injury among survivors of preterm birth. The hallmark of PWMI is hypomyelination and a lack of mature,...Full Text Available

2009-11-01

129

Optical Processing of Microwave Signals - Part B

PurposeCataracts are often considered to be an unavoidable consequence of aging. Oxidative damage is a major cause or consequence of cortical and nuclear cataracts, the most common...Full Text Available

2010-09-01

130

Ocean Planet:perils-deforestation - SeaWiFS - NASA

... switching off all the pixels causes all the spectrum lines to disappear (top of Figure 6), next, that switching off one ... Acousto-optic spectrum analyser ...

2003-04-01

131

Obesity and periodontal disease

Deforestation farther inland causes delayed reactions. When roots no longer hold soil in place, it ends up muddying streams, rivers, and coastal waters. ...

132

Non-opaque soft tissue foreign body: sonographic findings

Obesity is characterized by the abnormal or excessive deposition of fat in the adipose tissue. Its consequences go far beyond adverse metabolic effects on health, causing an increase in oxidative stress,...Full Text Available

2010-04-01

133

BackgroundSoft tissue foreign bodies are a common cause of orthopedic consultation in emergency departments. It is difficult to confirm their existence because conventional radiology...Full Text Available

134

Neurocysticercosis

Neonatal Sepsis and Neutrophil Insufficiencies

A single enhancing lesion in the brain parenchyma, also called an inflammatory granuloma, is a frequent neurologic diagnosis. One of the commonest causes of this lesion is human neurocysticercosis,...Full Text Available

2010-08-17

135

Mutations in RNA Binding Protein Gene Cause Familial Dilated Cardiomyopathy

Sepsis has continuously been a leading cause of neonatal morbidity and mortality despite current advances in chemotherapy and patient intensive care facilities. Neonates are at high risk for...Full Text Available

2010-06-01

136

Mitochondria and PGC-1? in Aging and Age-Associated Diseases

ObjectivesWe sought to identify a novel gene for dilated cardiomyopathy (DCM).BackgroundDCM is a heritable, genetically...Full Text Available

2009-09-01

137

Misfolded Proteins and Retinal Dystrophies

Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases...Full Text Available

138

Microbiologic Evaluation of Patients from Missouri with Erythema Migrans

Many mutations associated with retinal degeneration lead to the production of misfolded proteins by cells of the retina. Emerging evidence suggests that these abnormal proteins cause cell death...Full Text Available

2010-01-01

139

Methylisothiazolinone contact allergy and dose-response relationships

BackgroundBorrelia lonestari infects Amblyomma americanum, the tick species that is the most common cause of tick bites in southeast...Full Text Available

2005-02-01

140

DEFF Research Database (Denmark)

Methylisothiazolinone (MI) used alone is a new preservative causing a high prevalence of contact allergy. The eliciting threshold of MI is unknown. The combination of MI and phenoxyethanol enhances the antimicrobial efficacy of MI.

2011-01-01

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141

Metals and kidney autoimmunity.

Medical problems affecting musicians.

The causes of autoimmune responses leading to human kidney pathology remain unknown. However, environmental agents such as microorganisms and/or xenobiotics are good candidates for that role. Metals,...Full Text Available

1999-10-01

142

Managing Pain Caused By Neurological Disease

The physical demands of performing on musical instruments can cause pain, sensory loss, and lack of coordination. Five cases illustrate common problems. Knowledge of the interaction between the technique...Full Text Available

1995-12-01

143

Management of hyperlipidaemia: guidelines of the British Hyperlipidaemia Association.

Stabbing paroxysmal pain due to neurological disease can often be controlled by anticonvulsants, whereas steady burning pain is often responsive to tricyclic antidepressants, and to neuroleptics. Overuse...Full Text Available

1985-08-01

144

JPRS Report, East Asia: Southeast Asia.

There is considerable evidence to suggest that the identification and treatment of dyslipidaemia will reduce the risk of premature CHD, i.e. before the age of 65. Diagnosis of the cause of raised plasma...Full Text Available

1993-05-01

145

Ion channels, transporters, and pumps as targets for heart failure

... of the Philippines]-US Treaty of Friendship, Cooperation and Security is also causing some apprehen- sion among Taiwanese business sector, the ...

1991-11-20

146

Introduction to 'MINEO' project of European community and its enlightenments to monitoring and assessment of environmental impacts caused by mining in China

Congestive heart failure (CHF) is a leading cause of morbidity and mortality. CHF is marked by atrial and ventricular enlargement and reduced cardiac contractility, as well as an association...Full Text Available

2009-10-01

147

Intra-Vacuolar Proliferation of F. Novicida within H. Vermiformis

In order to promote environmental damage monitoring and environmental impacts assessment caused by mining in China, the most significant project that uses advanced Earth Observation technology to assess environmental impacts caused by mining, namely MINEO (assessment and monitoring the environmental impact of mining activities in Europe using advanced Earth Observation technology) was introduced and its enlightenment to China were investigated. It was proposed that an integrated technical framework of monitoring environmental impacts caused by mining be designed, quantitative inversion of biological and environmental parameters from RS data be emphasised, hyperspectral Remote Sensing be applied, RS and GIS be integrated with professional models, multi-object applications of RS be implemented, and related standards and specification be drawn up based on typical case study sites. 23 refs., 1 fig.

2008-01-15

148

Information flow, causality, and the classical theory of tachyons

Francisella tularensis is a gram negative facultative intracellular bacterium that causes the zoonotic disease tularemia. Free-living amebae, such as Acanthamoeba and...Full Text Available

149

In vivo MRI analysis of an inflammatory injury in the developing brain

Causal paradoxes arising in the tachyon theory have been systematically solved by using the reinterpretation principle as a consequence of which cause and effect no longer retain an absolute meaning. However, even in the tachyon theory, a cause is always seen to chronologically precede its effect, but this is obtained at the price of allowing cause and effect to be interchanged when required. A recent result has shown that this interchange-ability of cause and effect must not be unlimited if heavy paradoxes are to be avoided. This partial recovery of the classical concept of causality has been expressed by the conjecture that transcendent tachyons cannot be absorbed by a tachyon detector. In this paper the directional properties of the flow of information between two observers in relative motion and its consequences on the logical self-consistency of the theory of superluminal particles are analyzed. It ...

150

If I Had - Acne As a Young Female

Cerebral periventricular white matter injury stands as a leading cause of cognitive, behavioral and motor impairment in preterm infants. There is epidemiological and histopathological evidence...Full Text Available

2010-07-01

151

Medline Plus

... VIDEO: FASDs Cause More Severe Behavioral Problems Than ADHD, Baking Soda May Slow Chronic Kidney Disease, Higher ...

152

Hypersensitivity pneumonitis.

Francisella Tularensis Metabolism and its Relation to Virulence

Although the cause and development of most inflammatory and fibrotic interstitial lung diseases are unknown, both the antigenic stimuli and the immunopathogenic mechanisms that produce the syndrome...Full Text Available

1993-11-01

153

Female urethral syndrome. A female prostatitis?

Francisella tularensis is a Gram-negative bacterium capable of causing the zoonotic disease tularaemia in a large number of mammalian species and in arthropods. F. tularensis...Full Text Available

154

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model

The cause of the female urethral syndrome has previously been obscure, as it has been associated by definition with a lack of objective findings but a plethora of subjective complaints of retropubic...Full Text Available

1996-05-01

155

Effector Glycosyltransferases in Legionella

BackgroundMutations that disrupt the conversion of prelamin A to mature lamin A cause the rare genetic disorder Hutchinson-Gilford progeria syndrome and a group of laminopathies....Full Text Available

156

Effect of Smoking Scenes in Films on Immediate Smoking

Legionella causes severe pneumonia in humans. The pathogen produces an array of effectors, which interfere with host cell functions. Among them are the glucosyltransferases Lgt1, Lgt2...Full Text Available

157

Defective gut function in drop-dead mutant Drosophila

BackgroundThe National Cancer Institute has concluded that exposure to smoking in movies causes adolescent smoking and there are similar results for young adults.Full Text Available

2010-04-01

158

Cowper's syringocele: an analysis of 15 consecutive cases.

Mutation of the gene drop-dead (drd) causes adult Drosophila to die within 2 weeks of eclosion and is associated with reduced rates of defecation...Full Text Available

2009-09-01

159

Congenital Lobar Emphysema

Cystic dilatation of Cowper's gland ducts (Cowper's syringocele) is uncommon in children and is frequently asymptomatic, but it may cause urinary infection, haematuria, dysuria, and obstructive voiding...Full Text Available

1996-07-01

160

SummaryCongenital lobar emphysema (CLE) characterized by over distension and air-trapping in the affected lobe is one of the causes of infantile respiratory distress requiring...Full Text Available

2009-08-01

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161

Coal fire interferometry

Capsular Serotype and Antibiotic Resistance of Streptococcus pneumoniae Isolates in Two Chilean Cities

This BCRS project demonstrates the use of SAR interferometry for measuring and monitoring land subsidence caused by underground coal fires and underground mining in a remote area of north west China. China is the largest producer and consumer of coal in the world. Throughout the N.W., N. and N.E. of China, the coal-seams are very susceptible to spontaneous combustion, causing underground coal fires. As the thick coal seams are burned out, the overburden collapses, causing land subsidence, and producing new cracks and fissures, which allow more air to penetrate and continue the fire to spread. SAR interferometry, especially differential interferometry has been shown to be able to measure small differences in surface height caused by such land subsidence. This report describes the problems, the test area, the procedures and techniques used and the results obtained. It concludes with a description of some ...

2000-07-01

162

Cancer cells cause vascular endothelial cell (vEC) retraction via 12(S)HETE secretion; the possible role of cancer cell derived microparticle.

We compared the incidence of nasopharyngeal colonization by Streptococcus pneumoniae, the serotypes causing mucosal and invasive diseases, and the antibiotic resistance of these strains...Full Text Available

1998-03-01

163

Beach Erosion and Preventive Countermeasure at Kangnan Coast, Taiwan

PMID:17103063

2006-11-12

164

Arterial and Venous Thrombosis in Cancer Patients

... passed through Hsinchu, causing large waves: Mindulle (2004), Aere (2004) and Haitang (2005). These large, high-energy ... ...

165

Approaches to the evaluation of chemical-induced immunotoxicity.

The most frequent ultimate cause of death is myocardial arrest. In many cases this is due to myocardial hypoxia, generally arising from failure of the coronary macro- and microcirculation to deliver...Full Text Available

166

The immune system plays a crucial role in maintaining health; however, accumulating evidence indicates that this system can be the target for immunotoxic effects caused by a variety of chemicals including...Full Text Available

1995-12-01

167

Antimony Toxicity

An Experimental Investigation of Sandwich Flat Panels Under ...

Antimony toxicity occurs either due to occupational exposure or during therapy. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal...Full Text Available

2010-12-01

168

Adult and child malaria mortality in India

... Figure 1.4. Low Velocity Impact 1-4 Page 25. Damage of composite sandwich panels caused by low velocity impact has been ...

1994-12-01

169

Adhesion of Vibrio cholerae to Granular Starches

SummaryBackgroundMalaria, a non-fatal disease if detected promptly and treated properly, still causes many deaths in malaria-endemic countries with...Full Text Available

2010-11-20

170

Adder bite: an uncommon cause of compartment syndrome in northern hemisphere

Cholera is a severe diarrheal disease caused by specific serogroups of Vibrio cholerae that are pathogenic to humans. Cholera can become epidemic and deadly without adequate medical...Full Text Available

2005-08-01

171

AEC syndrome - Genetics Home Reference

Snakebite envenomation is an uncommon condition in the northern hemisphere, but requires high vigilance with regard to both the systemic effects of the venom and the locoregional impact on the soft...Full Text Available

172

A child with hyperferritinemia: Case report

What genes are related to AEC syndrome? AEC syndrome is caused by mutations in the TP63 gene. This gene provides instructions for making a protein known as p63, which plays an...

2011-10-15

173

A Novel Multi-Antigen Virally Vectored Vaccine against Mycobacterium avium Subspecies paratuberculosis

Hereditary hyperferritinemia cataract syndrome (HHCS) is a rare condition caused by mutations in the gene coding for the light chain of ferritin; it does not lead to iron overload, but it is associated...Full Text Available

174

BackgroundMycobacterium avium subspecies paratuberculosis causes systemic infection and chronic intestinal inflammation in many species including...Full Text Available

175

[Enzymatic pancreatogenic omental bursitis].

With more women entering the labor market, concern about adverse effects of occupational exposure on reproductive health has been increasing. Of special importance are those agents which might cause...Full Text Available

1983-06-01

176

Thermal fatigue failure at the White Cliffs solar thermal power plant

The most common causes of omental sac collections (OSC) are necrotic pancreatitis (90%) and pancreatic trauma (10%). Acute OSC is a form of local peritonitis in acute pancreatitis, subacute OSC are caused by internal pancreatic fistulas. The clinical and radiological signs, enzymatic activity of the exudate, morphological features of peritonitis were investigated. Treatment of acute OSC included conservative measures, of subacute OSC-surgical procedures. PMID:9163152

1996-01-01

177

Steam generator tube failures: experience with water-cooled nuclear power reactors during 1976

The failure of receivers has been one of the main operating problems at the White Cliffs solar thermal power plant. This Technical Note reports the results of an initial investigation that identifies the cause as having been their thermal fatiguing of the tube walls. The fatigue appears to be caused by unstable heat transfer at vapor qualities below the point where critical heat flux is generally exceeded. Methods for avoiding this problem are tested.

1995-02-01

178

Separation and Measurement of Plant Alkaloid Enantiomers by RP-HPLC Analysis of their Fmoc-Alanine Analogs

A survey was conducted of experience with steam generator tubes at nuclear power stations during 1976. Failures were reported at 25 out of 68 water-cooled reactors. The causes of these failures and the repair and inspection procedures designed to cope with them are summarized. Examination of the data indicates that corrosion was the major cause of steam generator tube failures. Improvements are needed in steam generator design, condenser integrity and secondary water chemistry control. (author).

1994-10-18

179

Pulmonary damage caused by cytostatics and paraquat

Plants often synthesize secondary metabolites that are enantiomers. Enantiomers can cause very different physiological responses. Ammodendrine (1) and anabasine (2) are teratogens that can cause congenital malformations in livestock and enantiomeric forms of each have been found in Lupinus spp. an...

180

Major steam turbine losses. Causes, repair measures, recommissioning; Grossschaeden an Dampfturbosaetzen. Ursachen, Reparaturen, Weiterbetrieb

Substances which exercise a pulmonary toxic action will first of all produce alveolar and perivascular oedemas followed by fibrosis. Differential diagnosis is explained on the basis of two cases of a fatal mitomycin fibrosis of the lung, as well as the observation of fibrous changes following the administration of Bleomycin and Metothrexat. The course of pulmonary fibroses caused by paraquat is described for two cases of fatal paraquat intoxications. (orig.).

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181

Hypotheses on forest decline as reflected by the results of surveys

Substantial damages at main components of steam turbines do not have to result inevitably in an exchange of the components concerned. Rather a preliminary or final repair is possible which also considers the cause of the damage. An important condition with the technically complex questions is an appropriate qualification and experience of all involved persons. The common task of operators, manufacturers and insurance companies is to preserve the balance from costs, expenditure of time and risk.

2010-07-01

182

Homozygosity Mapping Reveals Null Mutations in FAM161A as a Cause of Autosomal-Recessive Retinitis Pigmentosa

With reference to three hypotheses on the causes of forest decline, the manifold uses of forest decline surveys are demonstrated. Hypothesis no. 1: Forest disease from high-voltage transmission lines; hypothesis no. 2: Forest disease as the consequence of damage from micorrhizas; hypothesis no. 3: Radioactivity as the cause of the increased incidence of forest disease. (orig./MG)

1987-11-25

183

Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease

Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal degenerations caused by mutations in at least 45 genes. Using homozygosity mapping, we identified a ∼4 Mb homozygous region...Full Text Available

2010-09-10

184

Cause analysis of cracks in circulating water culvert of Daya Bay Nuclear Power Station

Outbreaks of disease attributable to human error or natural causes can provide unique opportunities to gain new information about host-pathogen interactions and new leads for pathogenesis research....Full Text Available

185

Blood EPA and DHA Independently Predict All-Cause Mortality in Patients with Stable Coronary Heart Disease. The Heart and Soul Study

In view of the widespread cracks discovered in the reinforced-concrete circulating water culvert of Daya Bay Nuclear Power Station, cause analysis for the cracks is made in terms of construction and design. It is concluded that the cracks mainly resulted from shrinkage and temperature. Corresponding countermeasures are put forward thereafter for reference of similar projects

2000-06-01

186

[Legionella pneumonia caused by aspiration of hot spring water after sarin exposure].

BackgroundOmega-3 fatty acid (n-3 FA) blood levels and intakes have been inversely associated with risk for sudden cardiac death, but their relationship with all-cause...Full Text Available

2010-07-01

187

Utility activities that create power quality problems

A 72-year-old man was exposed to the sarin gas attack in a Tokyo subway on March 20 th, 1995. After exposure, he noticed eye discomfort, chest tightness, headache and weakness of the lower limbs and oropharyngeal muscles. Despite these symptoms, he visited a hot spring on the same day with his family. On March 25 th, his muscle weakness progressed, and a low grade fever appeared. His muscle weakness disappeared 8 days after exposure to sarin, but respiratory failure rapidly developed, necessitating artificial ventilation within four day after hospitalization on March 28th. Chemotherapy with erythromycin, imipenem/cilastatin, and steroid pulse therapy was begu. PCR and culture of sputum collected by bronchofiberscopy were positive for Legionella pneumophila, serogroup I. His respiratory state improved, but subsequent infection with Pseudomonous aeruginosa. Enterobacter cloacae, and Candida tropicalis/glabrata caused his death 71 days after admission. Oropharyngeal ...

1998-03-01

188

River ice jams at bridges

Power quality problems are caused by activities normal to utility operations such as maintenance outages and capacitor switching or events that are abnormal such as lightning strikes and equipment failures. Disconnection and reconnection of transmission lines and transformers can cause switching surges, and are more severe on extra high voltage transmission lines than high voltage lines. Capacitor switching can cause transients and harmonics that may affect sensitive equipment, and are the source of 3rd, 5th, 7th and 9th harmonics in the hundreds of hertz ranges. Overload, sudden loss of generating capacity and transmission line faults are typical problems affecting system stability. Fault interruptions and reclosings can cause surges in the distribution system, and lightning strikes may cause voltage surges or dips due to arrester sparkover. Blackouts, brownouts, voltage ...

1992-02-01

189

Corrosion behaviour of non-ferrous metals in sea water

Ice jamming, known to cause high water levels at even moderate river flows, is described as both the main and least understood source of ice-related bridge damages. This paper describes a joint study by the New Brunswick Department of Transportation, the Department of the Environment, local governments, and the National Water Research Institute, designed to address problems associated with the interaction of ice jams and bridges. The study consists of collecting information at each of four sites in New Brunswick including: historical data on ice jam locations, causes, and water levels; channel bathymetry, width and slope within each study centred at the respective bridge; and documentation of ice conditions throughout the ice season, including measurement of ice cover thickness, observation of breakup mechanisms, times, causes, characteristics and possible impacts of ice jam release. Data analysis will include determination ...

2000-12-01

190

Significance of common cause failures in level-l PSA and techniques for reducing its impact on core damage frequency

The most typical kinds of corrosion of brasses are selective corrosion (dezincification) and stress corrosion. Prevention against these kinds of corrosion lies in application of arsenic alloy addition and appropriate heat treatment removing internal stresses as well as in maintaining the arsenic and phosphorus contents on a proper level. The most typical corrosion of cupronickels is the local corrosion. Selective corrosion occurs less often and corrosion cracking caused by stress corrosion in sea water does not usually occur. Crevice corrosion is found especially in places of an heterogeneous oxidation of the surface under inorganic deposits or under bio-film. Common corrosive phenomena for brasses and cupronickels are the effects caused by sea water flow and most often the impingement attack. Alloy additions improve resistance to the action of intensive sea water flow but situation in this field requires further improvement, especially if the ...

2004-07-01

191

Phorbol esters, protein kinase C, and thyroxine 5 prime -deiodinase in brown adipocytes

Failure of multiple components due to a common cause represents one of the most important issues in evaluation of system reliability or unavailability. The frequency of such events has relatively low expectancy, when compared to random failures, which affect individual components. However, in many cases the consequence is a direct loss of safety system or mitigative safety function. For this reason, the modeling of a common cause failure (CCF) and its presentation in fault tree structure is of the uttermost importance in probabilistic safety analyses (PSA). Amongst the different techniques available to reduce the impact of common cause failures, the most important operations related technique, is that of staggered testing. In the TAPP 3,4 Level-1 PSA it was found that the contribution of Common Cause Failures to the Core Damage Frequency (CDF) was significant. The Common Cause ...

2005-12-01

192

Nonverbal Learning Disability explained: the link to shunted hydrocephalus

Protein kinase C activity has been identified in the rat brown adipocyte. About 60% of this activity is found in the cytosolic fraction under basal conditions, and 12-O-tetradecanoylphorbol 13-acetate (TPA) causes a rapid shift from the cytosol to the particulate fraction. Norepinephrine and phenylephrine causes a similar redistribution that can be blocked by prazosin but not by alprenolol. {alpha}{sub 1}-Adrenergic agonists cause three- to fivefold stimulation of type 2 iodothyronine 5{prime}-deiodinase activity in brown adipocytes. TPA has no effect on basal deiodinase activity and reduces the response of the enzyme to {alpha}{sub 1}-adrenergic agonists. These results suggest that the translocation of protein kinase C from cytosol to particulate fraction is not sufficient to increase deiodinase activity but can modulate the {alpha}{sub 1}-adrenergic agonist-mediated responses in these cells.

1988-03-01

193

British Library Electronic Table of Contents (United Kingdom)

Accessible summary - -Children with a Nonverbal Learning Disability (NLD) resulting from shunted hydrocephalus and spina bifida face many difficulties not experienced by those with a language learning disability. - -As they grow older and more autonomy is expected, friendships became harder to sustain and daily life can be full of fear if the nonverbal learning disability is not identified and managed. - -This paper explains the theorised cause of nonverbal learning disability - damage to right hemisphere white matter or myelin. - -Damage is believed to cause problems with planning, organisation, time management, problem-solving, decision-making and friendships, and the mismatch with articulate speech and a good vocabulary causes a functional profile that is difficult for educationists or ...

2011-01-01

194

Network structure and phylogenetic signal in an artificially assembled plant-pollinator community

CERN Document Server

Community ecologists are principally occupied with the proposition that natural assemblages of species exhibit orderliness and with identifying its causes. Plant-pollinator networks exhibit a variety of orderly properties, one of which is 'nestedness'. Nestedness has been attributed to various causes, but we propose a further influence arising from the phylogenetic structure of the biochemical constraints on the pollen diets of bees. We use an artificial assemblage as an opportunity to isolate the action of this mechanism. The properties of the network that we studied are consistent with the proposition that nestedness is caused by the phylogeny of diet range in bees, but the claim is preliminary and we propose that valuable progress in understanding plant-pollinator systems may be made through applying the techniques of chemical ecology at the community scale.

2011-01-01

195

KMeyeDB: a graphical database of mutations in genes that cause eye diseases

British Library Electronic Table of Contents (United Kingdom)

KMeyeDB () is a database of human gene mutations that cause eye diseases. We have substantially enriched the amount of data in the database, which now contains information about the mutations of 167 human genes causing eye-related diseases including retinitis pigmentosa, cone-rod dystrophy, night blindness, Oguchi disease, Stargardt disease, macular degeneration, Leber congenital amaurosis, corneal dystrophy, cataract, glaucoma, retinoblastoma, Bardet-Biedl syndrome, and Usher syndrome. KMeyeDB is operated using the database software MutationView, which deals with various characters of mutations, gene structure, protein functional domains, and polymerase chain reaction (PCR) primers, as well as clinical data for each case. Users can access the database using an ordinary Internet browser wi...

2010-01-01

196

Exploring the patterns and causes of land use changes in south-west Sweden

British Library Electronic Table of Contents (United Kingdom)

To study the causes of agricultural declines in south-west Sweden, a multi-proxy study including pollen analysis, bog surface wetness indicators and aeolian sediment influx reconstructions was carried out on the Store Mosse Bog, situated on the coastal plain of Halland. Patterns of agricultural changes during the past 6,000?years from this study were compared to one additional site on the coastal plain (Undarsmosse Bog) and to four sites in the forested upland region. First, we compared land use activity on the coastal plain and in upland regions of south-west Sweden. Three periods with reduced agricultural activities were observed, primarily in records from the coastal plain. Next, the causes for these declines were studied by comparing land use indicators in the pollen records from the S...

2011-01-01

197

Effects of surfaces and leachables on the stability of biopharmaceuticals

British Library Electronic Table of Contents (United Kingdom)

Abstract Therapeutic proteins are exposed to various potential contact surfaces, particles, and leachables during manufacturing, shipping, storage, and delivery. In this review, we present published examples of interfacial- or leachable-induced aggregation or particle formation, and discuss the mitigation strategies that were successfully utilized. Adsorption to interfaces or interactions with leachables and/or particles in some cases has been reported to cause protein aggregation or particle formation. Identification of the cause(s) of particle formation involving minute amounts of protein over extended periods of time can be challenging. Various formulation strategies such as addition of a nonionic surfactant (e.g., polysorbate) have been demonstrated to effectively mitigate adsorption-i...

2011-01-01

198

Common-Cause Failure Analysis for Reactor Protection System Reliability Studies

Antigenic characterization of phocine distemper virus causing mass mortality in 2002 and its relationship to other morbilliviruses

Analyses were performed of the safety-related performance of the reactor protection system (RPS) at U.S. Westinghouse and General Electric commercial reactors during the period 1984 through 1995. RPS operational data from these reactors were collected from the Nuclear Plant Reliability Data System (NPRDS) and Licensee Event Reports (LER). The common-cause failure (CCF) modeling in the fault trees developed for these studies and the analysis and use of common-cause failure data were sophisticated, state-of-the-art efforts. The overall CCF effort helped to test and expand the limits of the U.S. Nuclear Regulatory Commission's CCF methodology.

1999-08-01

199

British Library Electronic Table of Contents (United Kingdom)

Summary The antigenic relationship between the phocine distemper virus (PDV) strain causing the epidemic in 2002 and the PDV strain of 1988, canine distemper virus from two dogs and one marten, and one measles virus strain was investigated in vivo and in vitro using monospecific polyclonal and monoclonal antibodies directed against five different proteins of canine or phocine distemper virus (N, P, M, F, H). Epitopic mapping revealed no difference between the PDV strains causing the epidemics in 1988 or 2002. However, the use of these antibodies allowed discrimination between different morbilliviruses including a vaccine strain of canine distemper virus. The major differences among the investigated morbilliviruses were found in the H protein.

2007-01-01

200

Adoptive immunotherapy with virus-specific T cells

British Library Electronic Table of Contents (United Kingdom)

Viral infections are still common causes of morbidity and mortality in immunosuppressed patients after allogeneic hematopoietic stem cell transplantation. Infections caused by virus such as cytomegalovirus, adenovirus and Epstein-Barr virus are well-known. In addition, several other viruses such as polyomavirus and human herpesvirus 6 have been recently reported to be causes of significant complications. As the delay in recovery of virus-specific cellular immune response after transplant is associated with viral reactivation and viral disease, adoptive immunotherapy to restore virus-specific cellular immunity is an attractive option. Recent clinical trials showed the safety and effectiveness of adoptive immunotherapy against viral diseases. In this review, we summarize the current status o...

2011-01-01

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201

cDNA-AFLP analysis reveals differential gene expression in compatible interaction of wheat challenged with Puccinia striiformis f. sp. tritici

X-ray dose enhancement effects

BackgroundPuccinia striiformis f. sp. tritici is a fungal pathogen causing stripe rust, one of the most important wheat diseases worldwide. The...Full Text Available

202

Wounding Nicotiana tabacum Leaves Causes a Decline in Endogenous Indole-3-Acetic Acid ¹

A brief description of the physical process of dose enhancement effects produced by X-ray radiation on materials is given, with emphasis on the influence on electronic devices. The damages caused by X-ray radiation dose enhancement is more serious than that of #gamma#-ray with higher energy.

203

Why Does Public Transport Not Arrive on Time? The Pervasiveness of Equal Headway Instability

We have previously observed that auxin can act as a repressor of the wound-inducible activation of a chimeric potato proteinase inhibitor II-CAT chimeric gene (pin2-CAT) in transgenic...Full Text Available

1991-07-01

204

Visible light and risk of age-related macular degeneration.

BackgroundThe equal headway instability phenomenon is pervasive in public transport systems. This instability is characterized by an aggregation of vehicles that causes inefficient...Full Text Available

205

Using a Pan-Viral Microarray Assay (Virochip) to Screen Clinical Samples for Viral Pathogens

Sunlight exposure has been suggested as a cause of AMD. To examine this, we collected detailed histories of ocular sun exposure in 838 watermen who work on the Chesapeake Bay. The presence and severity...Full Text Available

1990-01-01

206

Use of oral miltefosine for cutaneous leishmaniasis in Canadian soldiers returning from Afghanistan

The diagnosis of viral causes of many infectious diseases is difficult due to the inherent sequence diversity of viruses as well as the ongoing emergence of novel viral pathogens, such as SARS coronavirus...Full Text Available

207

Urinary Outflow Obstruction Increases Apoptosis and Deregulates Bcl-2 and Bax Expression in the Fetal Ovine Bladder

Old world cutaneous leishmaniasis (CL) is caused by Leishmania major and Leishmania tropica, and is endemic to several Asian and Middle-Eastern countries where the...Full Text Available

2008-11-01

208

Unusual occurrence of accessory central cusp in the maxillary second primary molar

During organogenesis, net growth of tissues is determined by a balance between proliferation, hypertrophy, and apoptotic death. Human fetal bladder outflow obstruction is a major cause of end-stage...Full Text Available

2003-04-01

209

Ubiquitin-Dependent Degradation of p53 Protein despite Phosphorylation at its N-Terminus by Acetaminophen

Accessory cusp present on the occlusal surface may seldom pose problems. While its presence may not be a cause for alarm in most instances, it can sometimes lead to serious consequences if it is damaged....Full Text Available

2011-04-01

210

Tuberous Sclerosis Complex Activity is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner

We previously reported that acetaminophen (APAP) caused apoptosis of C6 glioma cells. Therefore, we hypothesized that the level of p53, which usually stimulates apoptosis, might be increased...Full Text Available

2006-04-01

211

Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice

Tuberous Sclerosis Complex (TSC) is a neurogenetic disorder caused by loss-of-function mutations in either the TSC1 or TSC2 genes and frequently results in...Full Text Available

2009-05-06

212

Treatment with LL-37 Peptide Enhances Antitumor Effects Induced by CpG Oligodeoxynucleotides Against Ovarian Cancer

BackgroundThe dynorphin-kappa opioid receptor (KOR) system regulates glial proliferation after sciatic nerve injury. Here, we investigated its role in cell proliferation following...Full Text Available

213

Traumatic bronchial rupture: an unusual cause of tension pneumothorax

AbstractThere is an urgent need for innovative therapies against ovarian cancer, one of the leading causes of death from gynecological cancers in the United States. Immunotherapy employing...Full Text Available

2009-04-01

214

Transcriptional mapping of the 3' end of the bovine syncytial virus genome.

Bronchial rupture is a rare and serious complication of blunt chest trauma, which can be easily overlooked on initial evaluation in the emergency room (ER) as the focus of the attending physician is...Full Text Available

215

Total prosthetic replacement of atrioventricular valves in the dog

The bovine syncytial virus, a member of the retroviral subfamily Spumavirinae, causes a persistent, asymptomatic infection in cattle. Nucleotide sequence analysis of the viral genome revealed two overlapping...Full Text Available

1994-02-01

216

Tinea nigra by Hortaea werneckii, a report of 22 cases from Mexico

The metal parts of cardiac valve prostheses cause reactions in the surrounding tissues of the heart. In some dogs rather abnormal reactions were found, and were attributed to corrosion of the stainless...Full Text Available

1972-01-01

217

Tick-Borne Relapsing Fever in British Columbia, Canada: First Isolation of Borrelia hermsii

Tinea nigra is a superficial mycosis caused by Hortaea werneckii. It is an infrequent asymptomatic infection that affects human palms and soles, and is mostly observed in tropical...Full Text Available

2008-01-01

218

The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe Disease

The spirochete that causes tick-borne relapsing fever, Borrelia hermsii, was isolated in pure culture during 1995 and 1996 from three acutely ill human patients infected in southern...Full Text Available

1998-12-01

219

The protozoan parasite Theileria annulata alters the differentiation state of the infected macrophage and suppresses musculoaponeurotic fibrosarcoma oncogene (MAF) transcription factors

Krabbe disease (KD) is an inherited neurological disorder caused by the deficiency of galactocerebrosidase activity resulting in accumulation of psychosine, which leads to energy depletion,...Full Text Available

2008-06-01

220

The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms

AbstractThe tick-borne protozoan parasite Theileria annulata causes a debilitating disease of cattle called Tropical Theileriosis. The parasite predominantly invades...Full Text Available

2009-08-01

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221

The molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes angiokeratoma corporis diffusum with glycopeptiduria.

Reactive oxygen species (ROS), inevitable byproducts of aerobic metabolism, are known to cause oxidative damage to cells and molecules. This, in turn, is widely accepted as a pivotal determinant of...Full Text Available

2008-09-01

222

The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia.

Angiokeratoma corporis diffusum with glycopeptiduria is a recently recognized inborn error of glycoprotein catabolism resulting from the deficient activity of human alpha-N-acetylgalactosaminidase (E.C....Full Text Available

1994-08-01

223

The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis

An overall hypothesis for benzene-induced leukemia is proposed. Key components of the hypothesis include a) activation of benzene in the liver to phenolic metabolites; b) transport of these metabolites...Full Text Available

1996-12-01

224

The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template

Altered structure, and hence function, of cellular macromolecules caused by oxidation can contribute to loss of physiological function with age. Here, we tested whether the lifespan of bats, which generally...Full Text Available

2009-07-01

225

The causes, consequences, and treatment of left or right heart failure

Mutations in SOX9, a gene essential for chondrocyte differentiation cause the human disease campomelic dysplasia (CD). To understand how SOX9 activates transcription, we characterized...Full Text Available

2010-10-01

226

The burden of pneumococcal disease in children less than 5 years of age in Abu Dhabi, United Arab Emirates

Chronic heart failure (HF) is a cardiovascular disease of cardinal importance because of several factors: a) an increasing occurrence due to the aging of the population, primary and secondary prevention...Full Text Available

2011-01-01

227

The association between metal allergy, total hip arthroplasty, and revision

BACKGROUND AND OBJECTIVE:Streptococcus pneumoniae is a major cause of mortality and morbidity in both developing and industrialized countries, especially...Full Text Available

2011-07-01

228

The antimicrobial resistance patterns and associated determinants in Streptococcus suis isolated from humans in southern Vietnam, 1997-2008

Background and purpose It has been speculated that the prevalence of metal allergy may be higher in patients with implant failure. We compared the prevalence and cause of revisions following...Full Text Available

2009-12-04

229

The Use of a Mobile Laboratory Unit in Support of Patient Management and Epidemiological Surveillance during the 2005 Marburg Outbreak in Angola

BackgroundStreptococcus suis is an emerging zoonotic pathogen and is the leading cause of bacterial meningitis in adults in Vietnam. Systematic data on the antimicrobial...Full Text Available

230

The Potential Use of Electricity to Control Burrowing Shrimp in Oyster Aquaculture Beds

BackgroundMarburg virus (MARV), a zoonotic pathogen causing severe hemorrhagic fever in man, has emerged in Angola resulting in the largest outbreak of Marburg hemorrhagic fever...Full Text Available

231

The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model

Thalassinid shrimp cause significant problems for oyster aquaculture in the Pacific Northwest (USA) where oysters succumb to the physical disruption of the sediment by the burrowing activity of these animals. While electrofishing is a commonly used technique to capture fish and some invertebrates i...

232

The Effects of Time Varying Curvature on Species Transport in Coronary Arteries

Dominant mutations in sarcomere protein genes cause hypertrophic cardiomyopathy, an inherited human disorder with increased ventricular wall thickness, myocyte hypertrophy, and disarray. To understand...Full Text Available

2002-04-15

233

The Differential Expression of Aqueous Soluble Proteins in Breast Normal and Cancerous Tissues in Relation to Stage and Grade of Patients

Alterations in mass transport patterns of low-density lipoproteins (LDL) and oxygen are known to cause atherosclerosis in larger arteries. We hypothesise that the species transport processes in coronary...Full Text Available

2006-12-01

234

The Blind NasoTracheal Aspiration Method Is Not a Useful Tool for Pathogen Detection of Pneumonia in Children

Breast cancer is a leading cause of female deaths worldwide. In Malaysia, it is the most common form of female cancer while Infiltrating ductal carcinoma (IDC) is the most common form of breast cancer....Full Text Available

2010-01-01

235

The Aging Heart and Post-Infarction Left Ventricular Remodeling

BackgroundAcute lower respiratory infection (ALRI) is a major cause of hospitalization for children in China, while the etiological diagnosis of ALRI remains a challenge. This study...Full Text Available

236

Temporal trends in reproductive performance in Irish dairy herds and associated risk factors

Aging is a risk factor for heart failure, which is a leading cause of death world-wide. Elderly patients are more likely than young patients to experience a myocardial infarction (MI) and are...Full Text Available

2010-12-28

237

THE OGIP FORMAT FOR 2-D (IMAGE) POINT SPREAD FUNCTION ... - NASA

Irish dairy herd fertility has been declining since the 1980s. The extent, nature and causes of this decline in fertility and the current status of Irish dairy herd fertility were described....Full Text Available

238

Successful Treatment of Anterior Tracheal Necrosis after Total Thyroidectomy Using Vacuum-Assisted Closure Therapy

tial/angular spreading of incident photons from a point source caused by the instrument (de- .... Filter. CDTP0001= 'DATA. ' / Type of calibration. CCNM0001= '2D_PSF ' ... the final resolution of sigma=0.5 arcmin in all energy bands. ...

239

Total thyroidectomy involving the adjacent structures of the trachea can cause tracheal damage such as early tracheal necrosis. The authors describe the first case of anterior tracheal necrosis following...Full Text Available

2012-01-01

240

Stumbling in the smog

Storage of buffy-coat-derived platelets in additive solution: in vitro effects on platelets of the air bubbles and foam included in the final unit

The pollutants from the exhausts of internal combustion engines cause a range of illnesses and are the main source of atmospheric contamination. This article explores the options for curbing pollution in the UK including catalytic converters, electric cars, and natural gas cars. It is likely that the onus will remain with the car manufacturers for developing solutions. (UK)

1994-11-10

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241

Spontaneous coronary artery dissection in the postpartum period: association with antiphospholipid antibody

Background.The air bubbles and foam that develop during the preparation of platelet units have traditionally been considered to interact with the platelets, causing activation and...Full Text Available

2011-04-01

242

Spontaneous cervical epidural hematoma: Report of a case managed conservatively

Spontaneous coronary artery dissection (SCAD) is an extremely uncommon cause of myocardial infarction, occurring predominantly in women during or after pregnancy. The exact aetiology...Full Text Available

2004-09-01

243

Spinal Cord Stimulation for Intractable Visceral Pain due to Chronic Pancreatitis

Spontaneous spinal epidural hematoma is a rare cause of acute spinal cord compression. A 25-year-old male presented with a history of sudden onset of complete quadriplegia with sensory loss below the...Full Text Available

2008-07-01

244

Sodium/Calcium Exchangers Selectively Regulate Calcium Signaling in Mouse Taste Receptor Cells

Pain caused by chronic pancreatitis is medically intractable and resistant to conventional interventional or surgical treatment. We report a case of spinal cord stimulation (SCS) for intractable pain...Full Text Available

2009-08-01

245

Sodium bicarbonate-based hydration prevents contrast-induced nephropathy: a meta-analysis

Taste cells use multiple signaling mechanisms to generate appropriate cellular responses to discrete taste stimuli. Some taste stimuli activate G protein coupled receptors (GPCRs) that cause calcium...Full Text Available

2010-07-01

246

Sexually transmitted diseases: meeting the 1990 objectives--a challenge for the 1980s.

BackgroundContrast-induced nephropathy is the leading cause of in-hospital acute renal failure. This side effect of contrast agents leads to increased morbidity, mortality, and health...Full Text Available

247

Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed Perinatally to Immunotoxicants

Sexually transmitted diseases (STDs) represent a major public health problem in the country, cause patients enormous suffering, and cost the nation billions of dollars annually. Demographic, sociological,...Full Text Available

1982-09-01

248

Serratia odorifera biogroup 1 causing an invasive human infection.

BackgroundPolychlorinated biphenyls (PCBs) may cause immunotoxic effects, but the detailed dose–response relationship and possible vulnerable time windows of exposure are...Full Text Available

2010-10-01

249

Seroprevalence of HIV-1 and HIV-2 infection among children diagnosed with protein-calorie malnutrition in Nigeria.

Serratia odorifera biogroup 1 was isolated from the blood and urine of an alcoholic male with cirrhosis and signs of septic shock. The organism is rarely reported to occur in clinical specimens. This...Full Text Available

1988-06-01

250

Seasonal and Regional Dynamics of M. ulcerans Transmission in Environmental Context: Deciphering the Role of Water Bugs as Hosts and Vectors

Excessive weight loss due to protein calorie malnutrition (PCM) is a significant problem in Nigerian children. This syndrome may be difficult to differentiate from the wasting disease caused by human...Full Text Available

1993-04-01

251

Schindler disease: the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy.

BackgroundBuruli ulcer, the third mycobacterial disease after tuberculosis and leprosy, is caused by the environmental mycobacterium M. ulcerans. Various modes of...Full Text Available

252

Safety and immunogenicity of a vaccine bait containing ERA strain of attenuated rabies virus.

Schindler disease is a recently recognized infantile neuroaxonal dystrophy resulting from the deficient activity of the lysosomal hydrolase, alpha-N-acetylgalctosaminidase (alpha-GalNAc). The recent...Full Text Available

1990-11-01

253

Role in Virulence of a Brucella abortus Protein Exhibiting Lectin-Like Activity

Ninety percent of foxes fed commercial ERA vaccine in a specially designed bait developed rabies serum neutralizing antibodies. The vaccine bait did not cause clinical signs of rabies when consumed...Full Text Available

1987-10-01

254

Replication timing and transcriptional control: beyond cause and effect. Part II

Brucella abortus is a facultative, intracellular zoonotic pathogen which can cause undulant fever in humans and abortions in cattle. A 14-kDa protein of B. abortus...Full Text Available

2006-01-01

255

Renal functions in pediatric patients with beta-thalassemia major: relation to chelation therapy: original prospective study

SUMMARYReplication timing is frequently discussed superficially in terms of its relationship to transcriptional activity via chromatin structure. However, so little is known about...Full Text Available

2009-04-01

256

Recognition of historic influenza epidemics from parish burial records: a test of prediction from a new hypothesis of influenzal epidemiology.

BackgroundIn β-thalassemia, profound anemia and severe hemosiderosis cause functional and physiological abnormalities in various organ systems. In recent years, there have...Full Text Available

257

Receptor Binding Sites and Antigenic Epitopes on the Fiber Knob of Human Adenovirus Serotype 3

On the current conception of the epidemiology of epidemic influenza, as caused by a mechanism of direct spread of the virus from the sick, epidemics must have travelled much more slowly in former times...Full Text Available

1983-10-01

258

Recent changes in the epidemiology and management of extended-spectrum ?-lactamase-producing Enterobacteriaceae

The adenovirus fiber knob causes the first step in the interaction of adenovirus with cell membrane receptors. To obtain information on the receptor binding site(s), the interaction of labeled cell...Full Text Available

1998-11-01

259

Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients

Since 2000, Escherichia coli producing CTX-M enzymes (especially CTX-M-15) have emerged worldwide as important causes of community-onset urinary tract and blood stream infections due...Full Text Available

260

Randomized placebo-controlled trial on azithromycin to reduce the morbidity of bronchiolitis in Indigenous Australian infants: rationale and protocol

BackgroundFamilial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene. The vast majority of APC mutations...Full Text Available

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261

Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2)

BackgroundAcute lower respiratory infections are the commonest cause of morbidity and potentially preventable mortality in Indigenous infants. Infancy is also a critical time for...Full Text Available

262

Protein Targets of Reactive Metabolites of Thiobenzamide in Rat Liver In Vivo

Genomic disorders are conditions that result from DNA rearrangements, such as deletions or duplications. The identification of the dosage-sensitive gene(s) within the rearranged genomic interval is...Full Text Available

2006-11-01

263

Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450.

Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from...Full Text Available

2008-07-01

264

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety

Protection afforded by trialkyl phosphorothionates against the lung injury caused by trialkyl phosphorothiolates probably results from the inhibition by the P = S moiety of the thionates, of one or...Full Text Available

1990-04-01

265

Process and apparatus for chemically removing ash from coal

Preterm birth is the leading cause of neonatal mortality and morbidity and long-term disability of non-anomalous infants. Previous studies have identified a prior early spontaneous preterm birth as...Full Text Available

2009-01-01

266

Prevention of chain cleavage in the chemical synthesis of 2'-silylated oligoribonucleotides.

Finely divided ash-containing coal is immersed in an aqueous solution of hydrochloric acid or citric acid, and acidic ammonium fluoride to cause the ash to react with the acid and the acidic ammonium fluoride, and the deashed coal is thereafter separated from the solution.

1984-01-03

267

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Strong aqueous ammonium hydroxide used to remove N-acyl protecting groups from synthetic oligoribonucleotides causes removal of some alkylsilyl protecting groups from 2'-hydroxyls and leads to chain...Full Text Available

1989-05-11

268

Preterm low birthweight and the role of oral bacteria

ObjectiveTo determine the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and...Full Text Available

2007-05-01

269

Prediction of Skin Sensitization with a Particle Swarm Optimized Support Vector Machine

Preterm and low birthweight (PTLBW) continues to be a major cause of mortality and morbidity across the world. In recent years, maternal periodontal disease has been implicated as a risk factor for...Full Text Available

270

Postoperative retention of urine: a prospective urodynamic study.

Skin sensitization is the most commonly reported occupational illness, causing much suffering to a wide range of people. Identification and labeling of environmental allergens is urgently required to...Full Text Available

271

Plasticity of the cochleotopic (frequency) map in specialized and nonspecialized auditory cortices

OBJECTIVE--To investigate the cause of post-operative retention of urine in elderly men. DESIGN--Prospective study. SETTING--Northern General Hospital, Sheffield. PATIENTS--32 consecutive men (median...Full Text Available

1991-04-13

272

Pitfalls with the "chest compression-only" approach: the challenge of an unusual cause

Auditory conditioning (associative learning) causes reorganization of the cochleotopic (frequency) maps of the primary auditory cortex (AI) and the inferior colliculus. Focal electric stimulation...Full Text Available

2001-03-13

273

Phytochrome-induced Increase of Fluorescein Translocation in Mung Bean Hypocotyls

Chest compression-only (CC-only) is now incorporated in the Norwegian protocol for dispatch guided CPR (cardiopulmonary resuscitation) in cardiac arrest of presumed cardiac aetiology.We present...Full Text Available

274

Physiologic Compliance in Engineered Small-diameter Arterial Constructs Based on an Elastomeric Substrate

Moderate doses of red (660 nanometer) irradiation cause a rapid increase in the translocation of fluorescein in dark-grown mung bean hypocotyl (Vigna radiata L.) segments. The increase...Full Text Available

1978-07-01

275

Pesticide Mixtures, Endocrine Disruption, and Amphibian Declines: Are We Underestimating the Impact?

Compliance mismatch is a significant challenge to long-term patency in small-diameter bypass grafts because it causes intimal hyperplasia and ultimately graft occlusion. Current engineered grafts...Full Text Available

2010-03-01

276

Percutaneous absorption of aromatic amines in rubber industry workers: impact of impaired skin and skin barrier creams

Amphibian populations are declining globally at an alarming rate. Pesticides are among a number of proposed causes for these declines. Although a sizable database examining effects of pesticides on...Full Text Available

2006-04-01

277

Perception of blindness and blinding eye conditions in rural communities.

BackgroundSeveral aromatic amines (AA) could cause bladder cancer and are an occupational hygiene problem in the workplace. However, little is known about the percutaneous absorption...Full Text Available

2007-06-01

278

Peptide Nanoparticles as Novel Immunogens: Design and Analysis of a Prototypic Severe Acute Respiratory Syndrome Vaccine

PURPOSE: The purpose of this qualitative study was to explore the causes and management of blindness and blinding eye conditions as perceived by rural dwellers of two Yoruba communities in Oyo State,...Full Text Available

2006-06-01

279

PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

Severe acute respiratory syndrome (SARS) is an infectious disease caused by a novel coronavirus that cost nearly 800 lives. While there have been no recent outbreaks of the disease, the threat...Full Text Available

2009-01-01

280

Organophosphate acetylcholine esterase inhibitor poisoning from a home-made shampoo

Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the United States. The only available treatment, N-acetylcysteine (NAC), has a limited...Full Text Available

2010-10-05

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281

Ocular side effects of anti-rheumatic medications: what a rheumatologist should know

Organophosphate acetylcholine esterase inhibitor poisoning is a major health problem in children. We report an unusual cause of organophosphate acetylcholine esterase inhibitor poisoning. Two children...Full Text Available

2011-07-01

282

Ocular manifestations of branchio-oculo-facial syndrome: Report of a novel mutation and review of the literature

Nearly every drug may cause changes to ocular tissues through a variety of mechanisms. Medication overdoses, drug–drug interactions but also chronic administration of medications at...Full Text Available

2010-01-01

283

Obstructive Jaundice after Bilioenteric Anastomosis: Transhepatic and Direct Percutaneous Enteral Stent Insertion for Afferent Loop Occlusion

PurposeTo report unusual ocular manifestations of branchio-oculo-facial syndrome (BOFS) caused by a novel mutation in activating enhancer binding protein 2 alpha (TFAP2A).MethodsFull...Full Text Available

284

OLFACTORY CUES ARE SUFFICIENT TO ELICIT SOCIAL APPROACH BEHAVIORS BUT NOT SOCIAL TRANSMISSION OF FOOD PREFERENCE IN C57BL/6J MICE

Recurrent tumour after radical pancreaticoduodenectomy may cause obstruction of the small bowel loop draining the liver. Roux-loop obstruction presents a particular therapeutic challenge, since the...Full Text Available

2010-09-01

285

Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina

Mouse models for the study of autistic-like behaviors are increasingly needed to test hypotheses about the causes of autism, and to evaluate potential treatments. Both the automated 3-chambered...Full Text Available

2008-11-21

286

Novel Human Erythrovirus Associated with Transient Aplastic Anemia

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated...Full Text Available

287

Non-traumatic fractures following seizures: two case reports

Erythrovirus (formerly parvovirus) B19 causes a wide range of diseases in humans, including anemia due to aplastic crisis. Diagnosis of B19 infection relies on serology and the detection of viral DNA...Full Text Available

1999-08-01

288

New strain of mouse hepatitis virus as the cause of lethal enteritis in infant mice.

IntroductionSeizures with or without trauma may cause fractures that occur commonly in epileptic seizures. Fracture risk is less reported in non-epileptic seizures. Some metabolic...Full Text Available

289

New frontiers in ovarian cancer diagnosis and management.

A new strain of mouse hepatitis virus (MHV) was isolated from pooled gut suspensions from an epizootic of lethal enteritis in newborn mice. Negative-contrast electron microscopy showed an abundance...Full Text Available

1979-05-01

290

Neuronal regulation of cochlear blood flow in the guinea-pig.

Ovarian carcinoma is now the leading cause of death among women. Surgery has reached its limits, and further aggressive surgery will result in an inordinate morbidity and mortality. Ovarian carcinoma...Full Text Available

1991-03-01

291

Neurobehavioral Deficits and Increased Blood Pressure in School-Age Children Prenatally Exposed to Pesticides

1. Previous studies have shown that electrical stimulation (ES) of the guinea-pig cochlea causes a neurally mediated increase in cochlear blood flow (CBF). It is known that the centrifugal neuronal...Full Text Available

1994-11-01

292

NMDA Receptor Blockade with Memantine Attenuates White Matter Injury in a Rat Model of Periventricular Leukomalacia

BackgroundThe long-term neurotoxicity risks caused by prenatal exposures to pesticides are unclear, but a previous pilot study of Ecuadorian school children suggested that blood...Full Text Available

2010-06-01

293

Mycolic Acid Analysis by High-Performance Liquid Chromatography for Identification of Mycobacterium Species

Hypoxia–ischemia (H/I) in the premature infant leads to white matter injury termed periventricular leukomalacia (PVL), the leading cause of subsequent neurological deficits. Glutamatergic...Full Text Available

2008-06-25

294

Mutations in TPRN Cause a Progressive Form of Autosomal-Recessive Nonsyndromic Hearing Loss

Mycobacterium tuberculosis is the etiologic agent of tuberculosis and can be accurately detected by laboratories using commercial genetic tests. Nontuberculosis mycobacteria (NTM) causing other mycobacterioses...Full Text Available

2001-10-01

295

Multidrug resistant Kluyvera ascorbata septicemia in an adult patient: a case report

We performed genome-wide homozygosity mapping in a large consanguineous family from Morocco and mapped the autosomal-recessive nonsyndromic hearing loss (ARNSHL) in this family to the DFNB79...Full Text Available

2010-03-12

296

Mothers' concept of measles and attitudes towards the measles vaccine in Ile-Ife, Nigeria.

IntroductionKluyvera ascorbata has become increasingly significant due to its potential to cause a wide range of infections, as well as its ability to transfer gene...Full Text Available

297

Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans

The attitude of Nigerian mothers, mainly Yoruba, towards measles vaccine and other aspects of prevention are influenced by different perceptions of the cause of measles. There is a significant correlation...Full Text Available

1982-09-01

298

Molecular Epidemiology of Escherichia coli Producing Extended-Spectrum ?-Lactamases Isolated in Rome, Italy?

The fungus Cryptococcus neoformans is a major cause of morbidity and mortality in patients with impaired CD4⁺ T cell function, particularly those with AIDS. To identify...Full Text Available

2001-08-28

299

Modification of guanine bases by nucleoside phosphoramidite reagents during the solid phase synthesis of oligonucleotides.

Escherichia coli strains producing extended-spectrum β-lactamases (ESBLs) are a major problem in many different hospitals worldwide, causing outbreaks as well as sporadic infections....Full Text Available

2008-01-01

300

Mesencephalic and third ventricle cysts: diagnosis and management in four cases.

Nucleoside 3'-phosphoramidite and chlorophosphite reagents have been found to react with the lactam function of guanine. This reaction caused unsatisfactory results when oligodeoxyribonucleotides containing...Full Text Available

1985-09-25

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301

Meiotic recombination in the beta globin gene cluster causing an error in prenatal diagnosis of beta thalassaemia.

Four infants with obstructive hydrocephalus caused by space occupying third ventricle and mesencephalic cysts are reported. Despite immediate shunt insertion in all patients, there was either lack of...Full Text Available

1994-10-01

302

Medical records documentation of constipation preceding Parkinson disease

In the course of a prenatal diagnosis for beta thalassaemia by linkage analysis of restriction fragment length polymorphisms, a homozygous beta thalassaemia fetus was misdiagnosed as beta thalassaemia...Full Text Available

1988-05-01

303

Measurement of benign prostatic hyperplasia treatment effects on male sexual function

Objective:Parkinson disease (PD) may affect the autonomic nervous system and may cause constipation; however, few studies have explored constipation preceding the motor onset of...Full Text Available

2009-11-24

304

Massachusetts' approach to the prevention of heart disease, cancer, and stroke.

Benign prostatic hyperplasia (BPH) is the leading cause of lower urinary tract symptoms among the aging male population. Epidemiological, pathophysiological and clinical studies indicate that...Full Text Available

2009-01-01

305

Malignant pulmonary lesion. Possible causes of CT misdiagnosis; Possibilita' di falsi negativi nella diagnosi delle neoplasie polmonari con Tomografia Computerzzata

Heart disease, cancer, and cerebrovascular disease together cause more than two out of three deaths in the United States annually. These three diseases are largely a result of widespread risk factors...Full Text Available

1986-01-01

306

Malfunction of a Heimlich flutter valve causing tension pneumothorax: case report of a rare complication

The purpose of this work is to describe the radiological appearance of overlooked malignant pulmonary lesions at CT and to analyze the reasons of misdiagnosis. Ten patient with pulmonary lesion (PML) overlooked at forst CT examination were selected among patients with lung cancer. Endobronchial location of the tumors and their small size were the most frequent causes of misdiagnosis of PML at chest CT in the series. However, a systematic evaluation of CT scans can reduce the percentage of missed lesions. [Italian] Scopo del presente lavoro e' di descrivere le caratteristiche radiologiche delle lesioni polmonari maligne non identificate con la Tomografia Computerizzata (TC) e definire le possibili cause di errore. Sono stati esaminato 10 pazienti con tumore polmonare. Le sedi endobronchiale e centrale nonche' le piccole dimensioni delle lesioni polmonari maligne rappresentano le cause piu' ...

1999-06-01

307

Major inducing factors of hypertensive complications and the interventions required to reduce their prevalence: an epidemiological study of hypertension in a rural population in China

BackgroundThoracic injuries play an important role in major trauma patients due to their high incidence and critical relevance. A serious consequence of thoracic trauma is pneumothorax,...Full Text Available

308

MRI classification of interspinous ligament degeneration of the lumbar spine: intraobserver and interobserver reliability and the frequency of disagreement

BackgroundThe complications of hypertension cause severe health problems in rural areas in China. We (i) screened the major factors inducing hypertensive complications and provided...Full Text Available

309

MRI Findings of Pericardial Fat Necrosis: Case Report

Posterior spinal ligament pathology is becoming increasingly recognized as a significant cause of low back pain. Despite the growing clinical importance of interspinous ligament degeneration in low...Full Text Available

2010-10-01

310

Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice

Pericardial fat necrosis is an infrequent cause of acute chest pain and this can mimic acute myocardial infarction and acute pericarditis. We describe here a patient with the magnetic resonance imaging...Full Text Available

2011-05-01

311

Loss of ?-III spectrin leads to Purkinje cell dysfunction recapitulating the behaviour and neuropathology of SCA5 in humans

Retinal degenerative diseases, such as retinitis pigmentosa and Leber congenital amaurosis, are a leading cause of untreatable blindness with substantive impact on the quality of life of affected individuals...Full Text Available

2010-08-31

312

Liver Flukes: the Malady Neglected

Mutations in SPTBN2, the gene encoding β-III spectrin, cause spinocerebellar ataxia type 5 in humans (SCA5), a neurodegenerative disorder resulting in loss of motor...Full Text Available

2010-04-07

313

Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS

Liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts. Infection occurs through ingestion of fluke-infested, fresh-water raw fish. The most well-known species that cause...Full Text Available

2011-05-01

314

Layered Functional Network Analysis of Gene Expression in Human Heart Failure

BackgroundHuman immunodeficiency virus type 1 (HIV-1) infection frequently causes neurologic disease, which is the result of viral replication and activation of macrophages and microglia...Full Text Available

315

Lack of association between polymorphisms in C4b-binding protein and atypical haemolytic uraemic syndrome in the Spanish population

BackgroundAlthough dilated cardiomyopathy (DCM) is a leading cause of heart failure (HF), the mechanism underlying DCM is not well understood. Previously, it has been demonstrated...Full Text Available

316

Laboratory Investigation of Steam Adsorption in Geothermal Reservoir Rocks.

Dysregulation of the alternative pathway of complement activation, caused by mutations or polymorphisms in the genes encoding factor H, membrane co-factor protein, factor I or factor B, is associated...Full Text Available

2009-01-01

317

Knowledge and Awareness about Cervical Cancer and Its Prevention amongst Interns and Nursing Staff in Tertiary Care Hospitals in Karachi, Pakistan

Some vapor-dominated geothermal reservoirs and low-permeability gas reservoirs exhibit anomalous behavior that may be caused by surface adsorption. For example, geothermal reservoirs in the Larderello area of Italy and reservoirs in the Geysers Geothermal...

1988-01-01

318

Knockout of Arabidopsis ACCELERATED-CELL-DEATH11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense

Background and ObjectiveCervical cancer is one of the leading causes of morbidity and mortality amongst the gynecological cancers worldwide, especially in developing countries. It...Full Text Available

319

Investigation of the radiological safety concerns and medical history of the late Joseph T. Harding, former employee of the Paducah Gaseous Diffusion Plant

We describe the lethal, recessive accelerated-cell-death11 Arabidopsis mutant (acd11). Cell death in acd11 exhibits characteristics of animal apoptosis...Full Text Available

2002-02-15

320

Investigation of Residue and Coating Stoichiometry on 120-mm Combustible Cartridge Cases.

An ex-employee's claims that inadequate enforcement of radiation safety regulations allowed excess radiation exposure thereby causing his deteriorating health was not substantiated by a thorough investigation.

1981-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Intravascular ultrasound to guide the management of intracoronary thrombus: a Case Report

An investigation was conducted to determine the cause of coating residue found in the test gun chambers during qualification firing of 120-mm combustible cartridge case (CCC) ammunition for the MlAl/A2 main battle tank. The CCC is coated with a clear epox...

2000-01-01

322

Intragenomic conflict in populations infected by Parthenogenesis Inducing Wolbachia ends with irreversible loss of sexual reproduction

Percutaneous coronary intervention can be associated with distal embolization of thrombotic material causing myocardial necrosis and infarction.We discuss the role of intravascular imaging to...Full Text Available

323

Insect wing tarsal foreign body causing conjunctival granuloma and marginal keratitis

BackgroundThe maternally inherited, bacterial symbiont, parthenogenesis inducing (PI) Wolbachia, causes females in some haplodiploid insects to produce daughters...Full Text Available

324

Inhalation toxicity of vinyl chloride and Vinylidene chloride*

A 37 year old male was referred to our centre for management of episcleritis with peripheral keratitis in the right eye. He had a history of ocular discomfort in the right eye of 1 week duration. Slitlamp...Full Text Available

2009-11-01

325

Influence of macrofaunal assemblages and environmental heterogeneity on microphytobenthic production in experimental systems

Exposure of mice to 1000 ppm of vinyl chloride (VC), 6 hr/day, 5 days/week, caused some acute deaths with toxic hepatitis and marked tubular necrosis of the renal cortex. Starting the sixth month,...Full Text Available

1977-12-01

326

Industrial emissions cause extreme urban ozone diurnal variability

Despite the complexity of natural systems, heterogeneity caused by the fragmentation of habitats has seldom been considered when investigating ecosystem processes. Empirical approaches that have included...Full Text Available

2007-10-22

327

Increased Expression and Activity of Matrix Metalloproteinases Characterize Embolic Cardiac Myxomas

Simulations with a regional chemical transport model show that anthropogenic emissions of volatile organic compounds and nitrogen oxides (NO_x = NO + NO₂) lead to a dramatic diurnal...Full Text Available

2004-04-27

328

Increase in Internode Length of Phaseolus lunatus L. Caused by Inoculation with a Nitrate Reductase-deficient Strain of Rhizobium sp. ¹

Tumor embolism occurs in 30 to 50% of all cases of cardiac myxoma, but the causes are still uncertain. Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade the extracellular matrix...Full Text Available

2005-06-01

329

Incident report: spillage of reactor coolant at Wolsung

Dramatic differences in the height of lima beans (Phaseolus lunatus L.) treated with two different Rhizobium strains were studied. Lima beans were grown in Perlite...Full Text Available

1981-01-01

330

In vitro activities of purified visna virus integrase.

Late last year the Wolsung Candu in Korea suffered an incident which resulted in heavy water being released from the primary system into the containment. With the unit now back at full power, this article examines the causes of the incident and the action which is being taken to prevent it happening again.

1985-05-01

331

Imaging Improves Diagnosis of Dementia with Lewy Bodies

Although integration generally is considered a critical step in the retrovirus life cycle, it has been reported that visna virus, which causes degenerative neurologic disease in sheep, can productively...Full Text Available

1994-06-01

332

Identification of trkH, Encoding a Potassium Uptake Protein Required for Francisella tularensis Systemic Dissemination in Mice

Dementia with Lewy bodies (DLB) is the second most common cause of degenerative dementia after Alzheimer's disease (AD), and is clinically characterized by the progressive cognitive decline with fluctuations...Full Text Available

2009-12-01

333

Identification of Cardiac Myosin-binding Protein C as a Candidate Biomarker of Myocardial Infarction by Proteomics Analysis*

Francisella tularensis is a highly infectious bacterium causing the zoonotic disease tularaemia. During its infectious cycle, F. tularensis is not only exposed to the...Full Text Available

334

Identification and Characterization of CPS1 as a Hyaluronic Acid Synthase Contributing to the Pathogenesis of Cryptococcus neoformans Infection?

Acute myocardial infarction (AMI) is a common cause of death for which effective treatments are available provided that diagnosis is rapid. The current diagnostic gold standards are circulating cardiac...Full Text Available

2009-12-01

335

Hyaluronate levels in donor organ washout effluents: a simple and predictive parameter of graft viability

Cryptococcus neoformans is a pathogenic yeast that often causes devastating meningoencephalitis in immunocompromised individuals. We have previously identified the C. neoformans...Full Text Available

2007-08-01

336

Homozygous SLC2A9 Mutations Cause Severe Renal Hypouricemia

The principal cause of primary non-function in orthotopic liver transplantation is thought to be preservation injury to the microvasculature. We, therefore, evaluated if effluent levels of hyaluronate,...Full Text Available

1996-02-01

337

Historical Mammal Extinction on Christmas Island (Indian Ocean) Correlates with Introduced Infectious Disease

Hereditary hypouricemia may result from mutations in the renal tubular uric acid transporter URAT1. Whether mutation of other uric acid transporters produces a similar phenotype is unknown. We studied...Full Text Available

2010-01-01

338

High Glucose-Mediated Oxidative Stress Impairs Cell Migration

It is now widely accepted that novel infectious disease can be a leading cause of serious population decline and even outright extinction in some invertebrate and vertebrate groups (e.g., amphibians)....Full Text Available

339

Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis

Deficient wound healing in diabetic patients is very frequent, but the cellular and molecular causes are poorly defined. In this study, we evaluate the hypothesis that high glucose concentrations inhibit...Full Text Available

340

Heart Rate Characteristics: Physiomarkers for Detection of Late-Onset Neonatal Sepsis

Chronic colonization of the human stomach by Helicobacter pylori, a Gram-negative bacterium, is the major cause of chronic gastritis, peptic ulcers and gastric cancer. Recent...Full Text Available

2010-05-01

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341

Glycyrrhizin as antiviral agent against Hepatitis C Virus

SynopsisEarly detection of late onset neonatal sepsis, prior to obvious and potentially catastrophic clinical signs, is an important goal in neonatal medicine. Sepsis causes a...Full Text Available

2010-09-01

342

BackgroundHepatitis C virus is a major cause of chronic liver diseases which can lead to permanent liver damage, hepatocellular carcinoma and death. The presently available treatment...Full Text Available

343

Geothermal status report

Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent

This article examines the effects of competition of geothermal energy production with other technologies. The topics of the article include near-term market growth, cause for cautious optimism, limits to development of geothermal energy production, economic arguments for development of geothermal power plants, the effects of a competitive market on industry survival.

344

Genomic Expression Libraries for the Identification of Cross-Reactive Orthopoxvirus Antigens

Harmful algal blooms, caused by rapid growth and accumulation of certain microalgae in the ocean, pose considerable impacts on marine environments, aquatic industries and even public health. Here, we...Full Text Available

2005-01-01

345

Genome Sequence of Campylobacter jejuni strain 327, a strain isolated from a turkey slaughterhouse

Increasing numbers of human cowpox virus infections that are being observed and that particularly affect young non-vaccinated persons have renewed interest in this zoonotic disease. Usually causing...Full Text Available

346

Genetic Heterogeneity in Severe Congenital Neutropenia: How Many Aberrant Pathways Can Kill a Neutrophil?

Campylobacter is one of the leading causes of food-borne gastroenteritis and has a high prevalence in poultry. Campylobacter jejuni subsp. jejuni 327 is a subspecies...Full Text Available

347

Gene-Environment Interactions and Epigenetic Basis of Human Diseases

Purpose of reviewSevere congenital neutropenia (SCN) is a primary immunodeficiency in which lack of neutrophils causes inadequate innate immune host response to bacterial...Full Text Available

2007-12-01

348

Gene Therapy in the Retinal Degeneration Slow Model of Retinitis Pigmentosa

Most human diseases are related in some way to the loss or gain in gene functions. Regulation of gene expression is a complex process. In addition to genetic mechanisms, epigenetic causes are...Full Text Available

2008-01-01

349

Gardnerella vaginalis: characteristics, clinical considerations, and controversies.

Human blinding disorders are often initiated by hereditary mutations that insult rod and/or cone photoreceptors and cause subsequent cellular death. Generally, the disease phenotype can be predicted...Full Text Available

2010-01-01

350

Fungal Infection in Patients with Serpiginous Choroiditis or Acute Zonal Occult Outer Retinopathy?

The clinical significance, Gram stain reaction, and genus affiliation of Gardnerella vaginalis have been controversial since Gardner and Dukes described the organism as the cause of "nonspecific vaginitis,"...Full Text Available

1992-07-01

351

The etiologies of a number of retinopathies, including serpiginous choroiditis and acute zonal occult outer retinopathy (AZOOR), remain uncertain. Recently, we provided evidence that AZOOR is caused...Full Text Available

2008-01-01

352

Frozen shoulder.

Frequent Promoter Hypermethylation of the APC and RASSF1A Tumour Suppressors in Parathyroid Tumours

The frozen shoulder is a common cause of shoulder pain and disability. Most patients slowly improve over 12 to 24 months. Some have prolonged loss of movement, pain, and associated disability. Treatments...Full Text Available

1993-08-01

353

Forecasting changes in amphibian biodiversity: aiming at a moving target

BackgroundParathyroid adenomas constitute the most common entity in primary hyperparathyroidism, and although recent advances have been made regarding the underlying genetic cause...Full Text Available

354

Force enhancement without changes in cross-bridge turnover kinetics: the effect of EMD 57033.

Amphibian population declines and sudden species' extinctions began to be noted at the beginning of the 1980s. Understanding the causes of the losses is hampered by our poor knowledge of the amphibian...Full Text Available

2005-02-28

355

Feedback Effects of Host-Derived Adenosine on Enteropathogenic Escherichia coli

The thiadiazinon derivative EMD 57033 has been found previously in cardiac muscle to increase isometric force generation without a proportional increase in fiber ATPase, thus causing a reduction in...Full Text Available

1997-01-01

356

Fecal microRNAs as novel biomarkers for colon cancer screening

Enteropathogenic Escherichia coli (EPEC) is a common cause of watery diarrhea in children in developing countries. After adhering intimately to small intestinal cells, EPEC...Full Text Available

2009-12-01

357

Fatty Acid- and Retinoid-binding Proteins Have Distinct Binding Pockets for the Two Types of Cargo*

IntroductionColorectal cancer (CRC) is the second leading cause of cancer-related deaths, but currently available non-invasive screening programs have achieved only...Full Text Available

2010-07-01

358

Factors Predicting and Reducing Mortality in Patients with Invasive Staphylococcus aureus Disease in a Developing Country

Parasitic nematodes cause serious diseases in humans, animals, and plants. They have limited lipid metabolism and are reliant on lipid-binding proteins to acquire these metabolites from their hosts....Full Text Available

2009-12-18

359

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis

BackgroundInvasive Staphylococcus aureus infection is increasingly recognised as an important cause of serious sepsis across the developing world, with mortality...Full Text Available

360

Extracellular Administration of BCL2 Protein Reduces Apoptosis and Improves Survival in a Murine Model of Sepsis

Fibroblast growth factor (FGF) signaling is involved in skeletal development of the vertebrate. Gain-of-function mutations of FGF receptors (FGFR) cause craniosynostosis, premature fusion of the skull,...Full Text Available

2002-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma

BackgroundSevere sepsis and septic shock are major causes of morbidity and mortality worldwide. In experimental sepsis there is prominent apoptosis of various cell types, and genetic...Full Text Available

362

Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast

BackgroundNon-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize....Full Text Available

363

Exotic Small Mammals as Potential Reservoirs of Zoonotic Bartonella spp.

Spinocerebellar ataxia 10 (SCA10) is an autosomal dominant disease caused by large-scale expansions of the (ATTCT)_n repeat within an intron of the human ATXN10 gene. In contrast...Full Text Available

2011-02-15

364

Examination of transepithelial exchange of water and solute in the rat renal pelvis.

To evaluate the risk for emerging human infections caused by zoonotic Bartonella spp. from exotic small mammals, we investigated the prevalence of Bartonella spp. in...Full Text Available

2009-04-01

365

Evidence of a general 2/3-power law of scaling leaf nitrogen to phosphorus among major plant groups and biomes

Severance of the ureter beyond the renal papilla causes a fall in urinary osmolality, which suggests that exchange of water or solute between urine and renal parenchyma normally occurs in the intact...Full Text Available

1984-11-01

366

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

Scaling relations among plant traits are both cause and consequence of processes at organ-to-ecosystem scales. The relationship between leaf nitrogen and phosphorus is of particular interest, as both...Full Text Available

2010-03-22

367

Evaluation of Oral Administration of Adenine to Dogs and Primates.

DNA double-strand breaks (DSBs) are generally accepted to be the most biologically significant lesion by which ionizing radiation causes cancer and hereditary disease. However, no information on the...Full Text Available

2003-04-29

368

Evaluation of Colorimetric Methods Using Nicotinamide for Rapid Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis?

Little change was observed in primates fed 75 mg/kg adenine over the four-week period. Minimal tissue pathology was encountered upon completion of the study. In contrast to earlier studies in which oral feeding of adenine to dogs caused severe symptoms, a...

1974-01-01

369

Estimation of cancer incidence and mortality attributable to alcohol drinking in china

The direct detection of pyrazinamide resistance in Mycobacterium tuberculosis is sufficiently difficult that many laboratories do not attempt it. Most pyrazinamide resistance is caused...Full Text Available

2010-08-01

370

Epidemic giardiasis caused by a contaminated public water supply.

BackgroundCancer constitutes a serious burden of disease worldwide and has become the second leading cause of death in China. Alcohol consumption is causally associated with the...Full Text Available

371

Endobronchial Stent Insertion to Manage Hemoptysis caused by Lung Cancer

In the period November 1, 1985 to January 31, 1986, 703 cases of giardiasis were reported in Pittsfield, Massachusetts (population 50,265). The community obtained its water from two main reservoirs...Full Text Available

1988-02-01

372

Embryonic anti-aging niche

Hemoptysis in patients with lung cancer is not uncommon and sometimes have dangerous consequences. Hemoptysis has been managed with various treatment options other than surgery and medicine, such as...Full Text Available

2010-08-01

373

Electrolytic Reduction: Modification of Proteins Occurring in Isoelectric Focusing Electrophoresis and in Electrolytic Reactions in the Presence of High Salts

Although functional organ stem cells persist in the old, tissue damage invariably overwhelms tissue repair, ultimately causing the demise of an organism. The poor performance of stem cells in an aged...Full Text Available

374

Efficacy of ultrasound-guided obturator nerve block in transurethral surgery

Artifacts in two-dimensional electrophoresis (2-DE) caused by the presence of salts in isoelectric focusing (IEF) have been previously described as a result of increasing conductivity and inducing electroosmosis....Full Text Available

2009-05-15

375

Efficacy and cost-effectiveness of a physiotherapy program for chronic rotator cuff pathology: A protocol for a randomised, double-blind, placebo-controlled trial

Background:During transurethral resection surgery (TUR), accidental stimulation of the obturator nerve can cause violent adductor contraction, leading to serious intraoperative...Full Text Available

2011-01-01

376

Effects of extracts from Italian medicinal plants on planktonic growth, biofilm formation and adherence of methicillin-resistant Staphylococcus aureus

BackgroundChronic rotator cuff pathology (CRCP) is a common shoulder condition causing pain and disability. Physiotherapy is often the first line of management for CRCP yet there...Full Text Available

377

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep.

One-third of botanical remedies from southern Italy are used to treat skin and soft tissue infection (SSTI). Staphylococcus aureus, a common cause of SSTI, has generated increasing...Full Text Available

2008-08-13

378

Effects of cefonicid and other cephalosporin antibiotics on male sexual development in rats.

The effects of Escherichia coli endotoxin on lung mechanics, hemodynamics, gas exchange, and lung fluid and solute exchange were studied in 12 chronically instrumented unanesthetized sheep. A possible...Full Text Available

1983-07-01

379

Effects of Prolonged High Phosphorus Diet on Phosphorus and Calcium Balance in Rats

The purpose of this study was to determine whether cefonicid, a cephalosporin antibiotic with a modified N-methylthiotetrazole (MTT) side chain, caused testicular toxicity when subcutaneously administered...Full Text Available

1987-07-01

380

Ecological relevance of air pollution abatement measures as a decision aid

The amount of phosphorus contained in food as food additives is currently increasing and a high intake of phosphorus can cause various diseases. To determine the effects of a prolonged high phosphorus...Full Text Available

2007-05-01

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381

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

Air pollution abatement measures are not an end in themselves, and undesirable side effects should be taken into account. The proposed emission index takes into account the total emissions caused by a technical project as well as the effects of the individual pollutants.

1983-01-01

382

Double-Valve Libman-Sacks Endocarditis Causing Ventricular Fibrillation Cardiac Arrest

In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia. Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is mediated by the reduced...Full Text Available

2011-10-03

383

Does Damage to DNA and Other Macromolecules Play a Role in Aging? If So, How?

Libman-Sacks endocarditis is a well-known and rather common cardiac manifestation of systemic lupus erythematosus. Transesophageal and transthoracic echocardiography are the definitive imaging methods...Full Text Available

2011-01-01

384

Do Woody Plants Operate Near the Point of Catastrophic Xylem Dysfunction Caused by Dynamic Water Stress? ¹

One of the most pervasive ideas regarding the causes of aging is that longevity is constrained in large measure by damage to macromolecules. An increasing body of cellular and molecular data, generated...Full Text Available

2009-02-01

385

Differential Regulation of Mitogen-Activated Protein Kinase Pathways by Acetaminophen and Its Nonhepatotoxic Regioisomer 3?-Hydroxyacetanilide in TAMH Cells

We discuss the relationship between the dynamically changing tension gradients required to move water rapidly through the xylem conduits of plants and the proportion of conduits lost through embolism...Full Text Available

1988-11-01

386

Diagnosis of Ewing's sarcoma in the thoracic spine - problems in differential diagnosis

Acetaminophen (APAP), a widely used analgesic and antipyretic that is considered to be relatively safe at recommended doses, is the leading cause of drug-induced liver failure in the United States....Full Text Available

2010-07-01

387

Dexamethasone and nitric oxide synthase gene expression in brain.

Spinal Ewing's sarcomas are rare and cause problems in differential diagnosis. The radiologic, nuclear medicine and CT findings in two children with histologically proven Ewing's sarcoma are presented and problems in differential diagnosis discussed. Biopsy should be done early. (orig.).

388

Developmental gene regulation during tomato fruit ripening and in-vitro sepal morphogenesis

Systemic administration of lipopolysaccharide (LPS), which causes endotoxemia and systemic inflammation, has been reported to induce expression of the gene for type II inducible nitric oxide synthase...Full Text Available

1997-03-01

389

Development of an extrachromosomal cloning vector system for use in Borrelia burgdorferi

BackgroundRed ripe tomatoes are the result of numerous physiological changes controlled by hormonal and developmental signals, causing maturation or differentiation of various fruit...Full Text Available

390

Development of a New Serological Test for Serotyping Haemophilus parasuis Isolates and Determination of Their Prevalence in North America

Molecular genetic analysis of Borrelia burgdorferi, the cause of Lyme disease, has been hampered by the absence of any means of efficient generation, identification, and complementation...Full Text Available

2000-04-25

391

Determinants of Appropriate Child Health and Nutrition Practices among Women in Rural Gambia

Haemophilus parasuis causes polyserositis in swine. Fifteen serovars have been characterized by immunodiffusion test, but many field strains are not typeable. Isolates (n...Full Text Available

2004-02-01

392

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

Health education and awareness involves providing knowledge about causes of illness and choices to promote a change in individual behaviour and, thus, improves survival of individuals. Studies have,...Full Text Available

2010-04-01

393

Deaths and tumours among workers grinding stainless steel: a follow up.

Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by germline mutations in succinate dehydrogenase...Full Text Available

2011-01-04

394

DNA Damage during G2 Phase Does Not Affect Cell Cycle Progression of the Green Alga Scenedesmus quadricauda

OBJECTIVE: To study cause specific mortality and cancer morbidity in workers exposed to the dust of grinding materials, grinding agents, and stainless steel, especially with regard to a possibly increased...Full Text Available

1997-11-01

395

DDE and shortened duration of lactation in a northern Mexican town.

DNA damage is a threat to genomic integrity in all living organisms. Plants and green algae are particularly susceptible to DNA damage especially that caused by UV light, due to their light dependency...Full Text Available

396

Customizing systemic therapy in patients with advanced non-small cell lung cancer

OBJECTIVES. Worldwide declines in the duration of lactation are cause for public health concern. Higher levels of dichlorodiphenyl dichloroethene (DDE) have been associated with shorter durations of...Full Text Available

1995-04-01

397

Continuous and Periodic Expansion of CAG Repeats in Huntington's Disease R6/1 Mice

Lung cancer is the leading cause of cancer deaths worldwide. Standard chemotherapy has been shown to improve quality of life and has a modest influence on overall survival. This modest improvement in...Full Text Available

2011-07-01

398

Confronting the scientific obstacles to global control of tuberculosis

Huntington's disease (HD) is one of several neurodegenerative disorders caused by expansion of CAG repeats in a coding gene. Somatic CAG expansion rates in HD vary between organs, and the greatest instability...Full Text Available

2010-12-01

399

Comparison of ante-mortem assays to assess progression/regression of paratuberculosis in individual dairy animals

Tuberculosis (TB) is a major threat to global health, recently exacerbated by the emergence of highly drug-resistant forms of the disease-causing pathogen and synergy with HIV/AIDS. In 2006, the Stop...Full Text Available

2008-04-01

400

Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon

Johne disease, caused by Mycobacterium avium, subspecies paratuberculosis (MAP) is becoming increasingly widespread on dairy farms worldwide, due in part, to the absence...Full Text Available

2010-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Colonic polyps: inheritance, susceptibility, risk evaluation, and diagnostic management

BackgroundWhite spot syndrome (WSS) is a viral disease that affects most of the commercially important shrimps and causes serious economic losses to the shrimp farming industry worldwide....Full Text Available

402

Cocaine induces cell death and activates the transcription nuclear factor kappa-b in pc12 cells

Colorectal cancer (CRC) is the third-ranked neoplasm in order of incidence and mortality, worldwide, and the second cause of cancer death in industrialized countries. One of the most important environmental...Full Text Available

403

Cloning and expression of portions of the 34-kilodalton-protein gene of Mycobacterium paratuberculosis: its application to serological analysis of Johne's disease.

Cocaine is a worldwide used drug and its abuse is associated with physical, psychiatric and social problems. The mechanism by which cocaine causes neurological damage is very complex and involves several...Full Text Available

404

Circulating Matrix Metalloproteinases in Infective Endocarditis: A Possible Marker of the Embolic Risk

Paratuberculosis (Johne's disease), an endemic mycobacteriosis of cattle that is caused by Mycobacterium paratuberculosis, is characterized by incoercible diarrhea and fecal shedding of bacteria. The...Full Text Available

1993-04-01

405

Circadian Disruption and Metabolic Disease: Findings from Animal Models

BackgroundEmbolic events (EE) in infective endocarditis (IE) are caused by fragmentation of vegetations or valvular tissue. Vegetation length is considered to be the most potent...Full Text Available

406

Chronic Coronary Artery Disease: Diagnosis and Management

Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors...Full Text Available

2010-10-01

407

Characterization of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum?

Coronary artery disease (CAD) is the single most common cause of death in the developed world, responsible for about 1 in every 5 deaths. The morbidity, mortality, and socioeconomic importance...Full Text Available

2009-12-01

408

Characterization of Toxin Plasmids in Clostridium perfringens Type C Isolates?

Hookworms, bloodfeeding intestinal nematodes, infect nearly one billion people in resource limited countries and are a leading cause of anemia and malnutrition. Like other nematodes, hookworms...Full Text Available

2009-12-01

409

Cecal Schwannoma: A Rare Cause of Gastrointestinal Bleeding in a Young Woman with Review of Literature

Clostridium perfringens type C isolates cause enteritis necroticans in humans or necrotizing enteritis and enterotoxemia in domestic animals. Type C isolates always produce alpha toxin...Full Text Available

2010-11-01

410

Carpal Tunnel Syndrome and Peripheral Polyneuropathy in Patients with End Stage Kidney Disease

Schwannomas are rare mesenchymal tumors of the gastrointestinal tract. Occurrence of these tumors is more common in the stomach than in the large intestine. These tumors usually present as polypoidal...Full Text Available

2011-01-01

411

Carotenoid Crystal Formation in Arabidopsis and Carrot Roots Caused by Increased Phytoene Synthase Protein Levels

This study was designed to identify the causes of the development of carpal tunnel syndrome (CTS) associated with end stage kidney disease (ESKD). A total of 112 patients with ESKD, 64 on hemodialysis...Full Text Available

2011-09-01

412

Carney-Complex: Multiple resections of recurrent cardiac myxoma

BackgroundAs the first pathway-specific enzyme in carotenoid biosynthesis, phytoene synthase (PSY) is a prime regulatory target. This includes a number of biotechnological approaches...Full Text Available

413

CTX-M ?-Lactamase Production and Virulence of Escherichia coli K1

We report a case of a female patient who was operated at the third relapse of an atrial myxoma caused by Carney complex. The difficult operation was performed without any complications despite extensive...Full Text Available

414

CP Violation in Top Physics at the NLC

We report a patient with neonatal meningitis caused by a CTX-M-1–producing Escherichia coli K1 strain. The influence of CTX-M production on virulence was investigated in cell...Full Text Available

2009-12-01

415

CERN Document Server

Top quark is extremely sensitive to non-standard CP violating phases. General strategies for exposing different types of phases at the NLC are outlined. SUSY phase(s) cause PRA in $t\\to Wb$. The transverse polarization of the $\\tau$ in the reaction $t\\to b\\tau\

1996-01-01

416

C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin Trafficking

Breakdown of the Blood-Brain Barrier during Tick-Borne Encephalitis in Mice Is Not Dependent on CD8⁺ T-Cells

Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin trafficking and is...Full Text Available

417

Bragg curves of fission fragments in gases

Tick-borne encephalitis (TBE) virus causes severe encephalitis with serious sequelae in humans. The disease is characterized by fever and debilitating encephalitis that can progress to chronic illness...Full Text Available

418

Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment

An unexpectedly high probability of collisions between the fission particles and the atoms in an ionization chamber along the entire particle track causes a strong fluctuation of the shapes of the Bragg curves. This fluctuation imposes an upper limit of the charge resolution ..delta..Z/Z which can be achieved.

1986-03-01

419

Blood conservation strategies to reduce the need for red blood cell transfusion in critically ill patients

BackgroundCardiovascular disease (CVD) is a leading cause of mortality in the United States as well as globally. Epidemiological studies show that regular fruit and vegetable consumption...Full Text Available

420

Biogeography of Tick-Borne Bhanja Virus (Bunyaviridae) in Europe

Anemia commonly affects critically ill patients. The causes are multifactorial and include acute blood loss, blood loss from diagnostic testing and blunted red blood cell production. Blood transfusions...Full Text Available

2008-01-01

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421

Bacterial lipopolysaccharide induces an endocrine switch from prostaglandin F_2? to prostaglandin E₂ in bovine endometrium

Bhanja virus (BHAV) is pathogenic for young domestic ruminants and also for humans, causing fever and affections of the central nervous system. This generally neglected arbovirus of the family Bunyaviridae...Full Text Available

2009-01-01

422

Autoimmune pancreatitis with atypical imaging findings that mimicked an endocrine tumor

Escherichia coli infection of the endometrium causes uterine disease after parturition and is associated with prolonged luteal phases of the ovarian cycle in cattle. Termination...Full Text Available

2009-04-01

423

BUBL LINK: Lung cancer

Wastenet

...2 Resource type: documents Mesothelioma Information HON-code certified resource, covering the main aspects of asbestos exposure: diagnosis, diseases caused by asbestos, treatment options, prevention and legal options. Diagrams are included in articles, and links are provided to the references used. Also contains a listing of ...

424

Attenuated Salmonella typhimurium reduces ovalbumin-induced airway inflammation and T-helper type 2 responses in mice

Autoimmune pancreatitis (AIP) is a rare cause of recurrent acute pancreatitis or chronic pancreatitis in middle-aged patients, and is characterised by a marked infiltration of lymphocytes and plasma...Full Text Available

2010-06-21

425

Association of B-Type Natriuretic Peptide Levels With Estimated Glomerular Filtration Rate and Congestive Heart Failure

Cytokines produced by Th2 cells are responsible for the pathogenesis of asthma. Th1-biased immune responses caused by attenuated salmonella have the potential to relieve asthmatic symptoms. We evaluated...Full Text Available

2006-07-01

426

Association between skin diseases and severe bacterial infections in children: case-control study

Background: The causes of elevated B-Type natriuretic peptide (BNP) levels are multifactorial. Renal dysfunction has been shown to affect BNP levels in some studies and...Full Text Available

2010-03-01

427

Are natural radioactive materials dangerous

BackgroundSepsis or bacteraemia, however rare, is a significant cause of high mortality and serious complications in children. In previous studies skin disease or skin infections...Full Text Available

428

Apoptosis induced by parasitic diseases

The different radiation loads caused by natural and artificial radionuclides are compared in this paper. This examples will serve to illustrate that the problem of population exposure to radiation can only be solved in consideration of all components and to show which effects of the radiation from natural sources are of special importance in this connexion. (orig./AK).

1974-09-23

429

Anxiety in Patients with Cardiac Disease.

Fatalities caused by parasitic infections often occur as a result of tissue injury that results from a form of host-cell death known as apoptosis. However, instead of being pathogenic, parasite-induced...Full Text Available

430

Angina with a normal coronary angiogram caused by amyloidosis

Anxiety may cause adverse outcomes through physiologic pathways in patients with cardiac disease. The purpose of this dissertation was to investigate anxiety and its correlates in persons with acute myocardial infarction (AMI) and heart failure (HF). The ...

2005-01-01

431

Analysis on the alterations of lens proteins by Vitex negundo in selenite cataract models

A case of severe intractable angina pectoris with normal angiography is presented. Following video assisted thoracic sympathectomy the patient died of heart failure. Microvascular cardiac amyloidosis...Full Text Available

2004-09-01

432

Analysis of the genome-wide variations among multiple strains of the plant pathogenic bacterium Xylella fastidiosa

PurposeCataract is the leading cause of blindness and is associated with oxidative damage and protein modification in the lens. In the present study, we have employed proteomic and...Full Text Available

433

An unusual presentation of metastatic adenocarcinoma of lung: a case report

BackgroundThe Gram-negative, xylem-limited phytopathogenic bacterium Xylella fastidiosa is responsible for causing economically important diseases in grapevine,...Full Text Available

434

An ounce of prevention or a pound of cure: bioeconomic risk analysis of invasive species.

We report an unusual patient with primary adenocarcinoma of lung causing malignant pleural and pericardial effusions. The diagnosis was made only at autopsy as his staging computed tomography scan of...Full Text Available

435

An optimal design method for improving the lightning performance of overhead high voltage transmission lines

Numbers of non-indigenous species--species introduced from elsewhere - are increasing rapidly worldwide, causing both environmental and economic damage. Rigorous quantitative risk-analysis frameworks,...Full Text Available

2002-12-07

436

An imbalance between apoptosis and proliferation contributes to follicular persistence in polycystic ovaries in rats

This paper presents a method for the optimal design of high voltage transmission lines taking into consideration shielding and backflashover failure rates. The minimization of suitably defined performance indices, which relate the failures caused by lightning in a transmission line to both line insulation level and tower footing resistance, is aimed. Optimum values for both line insulation level and tower footing resistance are calculated. The method is applied on several operating Hellenic transmission lines of 150 and 400kV, respectively, carefully selected among others, due to their high failure rates during lightning thunderstorms. Special attention has been paid on open loop lines, where a possible failure could bring the system out of service causing significant problems. The obtained design parameters, which reduce the failure rates caused by lightning, are compared with the existing design parameters of the ...

2006-04-15

437

Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study

BackgroundCystic ovarian disease is an important cause of infertility that affects bovine, ovine, caprine and porcine species and even human beings. Alterations in the ovarian micro-environment...Full Text Available

438

Allergy and Sensitization during Childhood Associated with Prenatal and Lactational Exposure to Marine Pollutants

BackgroundMale infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding...Full Text Available

439

Alleged Mycotoxicosis in Swine: Review of a Court Case

BackgroundBreast-feeding may affect the risk of developing allergy during childhood and may also cause exposure to immunotoxicants, such as polychlorinated biphenyls (PCBs), which...Full Text Available

2010-10-01

440

Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia

Vomition and diarrhea in feeder pigs, and signs of hyperestrogenism in sows and pregnant gilts in a large swine operation were thought to be caused by mycotoxins. Various toxicoanalytical tests performed...Full Text Available

1981-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Affinity maturation of human botulinum neurotoxin antibodies by light chain shuffling via yeast mating

Brain edema is frequently shown after cerebral ischemia. It is an expansion of brain volume because of increasing water content in brain. It causes to increase mortality after stroke. Agmatine, formed...Full Text Available

2010-05-01

442

Acute aortic thrombosis in patients receiving cisplatin-based chemotherapy

Botulism is caused by the botulinum neurotoxins (BoNTs), the most poisonous substance known. Because of the high potency of BoNT, development of diagnostic and therapeutic antibodies for botulism requires...Full Text Available

2010-04-01

443

Acute Drug-Induced Hepatitis Caused by Albendazole

The increased risk of thrombosis in patients with active cancer has multiple causes. Acute thrombosis of the aorta is an exceedingly rare but potentially devastating complication in patients with cancer...Full Text Available

2011-04-01

444

Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction

Albendazole binds to parasite's tubulin inhibiting its glucose absorption. Its common adverse effects are nausea, vomiting, constipation, thirst, dizziness, headache, hair loss and pruritus. Although...Full Text Available

2008-10-01

445

A wide spectrum of clinical and brain MRI findings in patients with SLC19A3 mutations

BackgroundChronic kidney disease and end-stage renal disease are major causes of morbidity and mortality that are seen far more commonly in the aged population. Interestingly, kidney...Full Text Available

446

A randomised clinical trial of intrapartum fetal monitoring with computer analysis and alerts versus previously available monitoring

BackgroundSLC19A3 (solute carrier family 19, member 3) is a thiamin transporter with 12 transmembrane domains. Homozygous or compound heterozygous mutations in SLC19A3 cause...Full Text Available

447

A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention

BackgroundIntrapartum fetal hypoxia remains an important cause of death and permanent handicap and in a significant proportion of cases there is evidence of suboptimal care related...Full Text Available

448

A cross-sectional study of Tritrichomonas foetus infection among healthy cats at shows in Norway

BackgroundCentrosome aberrations can cause genomic instability and correlate with malignant progression in common human malignancies such as breast and prostate cancer. Deregulation...Full Text Available

449

A cost-utility analysis of nursing intervention via telephone follow-up for injured road users

BackgroundIn recent years, the protozoan Tritrichomonas foetus has been recognised as an important cause of chronic large-bowel diarrhoea in purebred cats in many...Full Text Available

450

A Vasculature-Targeting Regimen of Pre-Operative Docetaxel with or without Bevacizumab for Locally Advanced Breast Cancer

BackgroundTraffic injuries can cause physical, psychological, and economical impairment, and affected individuals may also experience shortcomings in their post-accident care and...Full Text Available

451

A Substructure Combination Strategy to Create Potent and Selective Transthyretin Kinetic Stabilizers that Prevent Amyloidogenesis and Cytotoxicity

PurposeTaxanes have effects on angiogenesis causing difficulties in separating biologic effects of chemotherapy from those due to angiogenesis inhibitors. This randomized...Full Text Available

2009-05-15

452

A Rare Case of Fatal Haemorrhage After Tracheostomy

Transthyretin aggregation-associated proteotoxicity appears to cause several human amyloid diseases. Rate-limiting tetramer dissociation and monomer misfolding of transthyretin (TTR) occur before...Full Text Available

2010-02-03

453

A Dominant Role for the Immunoproteasome in CD8⁺ T Cell Responses to Murine Cytomegalovirus

Tracheo-arterial fistula after tracheostomy causing massive haemorrhage is fortunately rare, but can be serious and often fatal. Brachiocephalic trunk is commonly at risk of erosion because of its close...Full Text Available

2007-11-01

454

A Cytogenetic Abnormality and Rare Coding Variants Identify ABCA13 as a Candidate Gene in Schizophrenia, Bipolar Disorder, and Depression

Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates...Full Text Available

455

A Cross-Model Comparison of Human Performance Modeling Tools ...

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of ∼80% indicating a substantial genetic component. Population genetics...Full Text Available

2009-12-11

456

A Computational Framework Discovers New Copy Number Variants with Functional Importance

Scheduling is a stochastic process performed by production rules. In .... activated, which causes the available goal queue size to be exceeded, then the first goal to ...... when in doubt turn toward the terminal or when in doubt go ...

457

?? T cells and Th17 cytokines in Hypersensitivity Pneumonitis and Lung Fibrosis

Structural variants which cause changes in copy numbers constitute an important component of genomic variability. They account for 0.7% of genomic differences in two individual genomes, of which...Full Text Available

458

Uncertainties of radionuclide migration parameter values obtained from in-situ tracer experiments

Hypersensitivity pneumonitis (HP) is an inflammatory lung disease caused by repeated inhalation of aerosolized antigens. With chronic exposure to an inhaled antigen, patients are at risk of...Full Text Available

2009-11-01

459

Studies on the CRUD Deposition on Fuel Cladding Surface Using AOA Water Chemistry Loop

One of the key issues in safety assessment of high-level nuclear waste disposal is evaluating the effects of uncertainty inherent in radionuclide migration parameter values. In this paper, radionuclide transport parameter values and error variances (uncertainties) from in-situ tracer experiments, carried out in a single fracture at the Aespoe Hard Rock Laboratory (HRL) in Sweden, are identified by solving the inverse problem in a framework of the maximum likelihood theory. From the results, it is found that the parameter value uncertainty caused by a conceptual model of radionuclide migration is greater than that caused by a fluctuation in the observed breakthrough curve data. (author)

2005-10-03

460

Some sources of error in property indices for coke-oven charge

Axial offset anomaly (AOA) is caused by the deposition of crud on the fuel cladding of a PWR. When significant levels of crud build up on the cladding, boron can accumulate in the pores of the crud as a concentrated solution or solid phase, and cause the flux depression. Numerous studies have been conducted on the primary water chemistry to reduce the amount of crud in the primary circuit to avoid radioactivity buildup and unexpected power transition in the plant. However, experiments on the crud are restricted in the laboratory because the crud is a highly radioactive material. The objective of this study is to develop a test method for simulating the deposition of crud in a nuclear power plant

2010-10-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Optical pressure on thin film caused by a Gaussian beam-generated evanescent wave

The author points out that errors in certain measurements are preventing improvements in coke: thermocouples (errors caused by the thermocouple installation and variations in the temperature of the cold junctions); dilatometers (errors caused by size of heating block and differences in starting temperature led to differences between two instruments); errors in measuring the bulk density of the coking charge. The elimination of these sources of error in determinations of the technological and physical properties of coke oven charge should assist in the study of other problems which are delaying improvements in blast furnace coke production.

1981-01-01

462

Landslides affecting sedimentary characteristics of reservoir basin

The optical pressure exerted o a thin film, which is locked in the evanescent field formed at the plane interface with a totally-reflected Gaussian beam, is investigated. Some calculations of the pressure on the film caused by the evanescent field are presented in the different conditions of film thickness, film position, incident angle and polarization of a gaussian beam. The results show that the pressure exertion on the thin film can change from pushing to pulling as the parameters are varied. In particular, we find that the direction of optical pressure can act oppositely at the different positions of the film surface in the evanescent field.

1994-11-01

463

British Library Electronic Table of Contents (United Kingdom)

Typhoons Aere (2004) and Matsa (2005) caused high nephelometric turbidity in the Shihmen reservoir in northern Taiwan, jeopardizing the operation of the reservoir for several days, and ultimately impacting the living conditions and economy of the downstream residents. The torrential rains caused landslides and debris flows in upland areas, and flowed into riverbeds, likely contributing significantly to the suspended sediment yields in the reservoir. This investigation elucidates how upland landslides affect sediment attributes in the reservoir basin. Study methods including field observations, spatial analysis in GIS and aerial photo interpretation are adopted to trace the sediment sources and contributing factors to the landslide. Torrential rains induced landslides and debris-flows uplan...

2010-01-01

464

LES benchmark study of high cycle temperature fluctuations caused by thermal striping in a mixing tee

Interpolation theory and influence of boundary conditions on room air diffusion

Thermal striping is identified as one of the causes of thermal fatigue failure in nuclear power plants. Numerical studies of thermal striping require three-dimensional, unsteady turbulent modeling that resolves both large and small-scale turbulent motions. Benchmark studies were carried out using the LES turbulence model solved by the commercial CFD code FLUENT. Two types of mixing tee configurations were modeled to evaluate the performance of the CFD code. The simulation results presented in normalized average temperature and normalized fluctuating temperatures are in good agreement with measurements.

2006-02-15

465

Interaction of water with epoxy.

This paper analyses the errors caused by interpolation from existing cases for assessing indoor air flow, air quality and thermal comfort in an office. A sensitivity study is then provided to determine the influence of several boundary conditions on indoor air diffusion. The research is conducted numerically by using a low-Reynolds-number k-{epsilon} model. It can be concluded that the interpolation errors caused by the variations of solar radiation, window size, heat source location due to lighting, and the surface temperatures of interior walls are small and can be quantitatively determined. But it is difficult to estimate the errors introduced by the variations of furniture location and size. (author).

1991-01-01

466

Inborn Errors of Metabolism Presenting in Childhood

The chemistries of reactants, plasticizers, solvents and additives in an epoxy paint are discussed. Polyamide additives may play an important role in the absorption of molecular iodine by epoxy paints. It is recommended that the unsaturation of the polyamide additive in the epoxy cure be determined. Experimental studies of water absorption by epoxy resins are discussed. These studies show that absorption can disrupt hydrogen bonds among segments of the polymers and cause swelling of the polymer. The water absorption increases the diffusion coefficient of water within the polymer. Permanent damage to the polymer can result if water causes hydrolysis of ether linkages. Water desorption studies are recommended to ascertain how water absorption affects epoxy paint.

2009-07-01

467

British Library Electronic Table of Contents (United Kingdom)

Abstract Neurodegenerative and neurometabolic disorders may cause significant morbidity and mortality in children. Imaging is important in early diagnosis of metabolic disorders and in determining the extent of brain injury. Especially after the development of new techniques such as diffusion-weighted magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), neuroimaging plays more important role in the diagnosis and management of these disorders. In these disorders, usually a mutation causes a clinically significant block in one or more metabolic pathways. This blockage usually results in either a deficiency of the product or in an accumulation of substrate with damage induced by either storage or toxicity. The presenting symptoms are usually nonspecific. In some of the ...

2011-01-01

468

Fast starting cold shield cooling circuit for superconducting generators

Failure analysis on a ruptured petrochemical pipe

An apparatus is provided for rapidly restarting the flow of coolant through the cold electromagnetic shield of a superconducting rotor following a thermal transient episode. A vortex diode inhibits coolant flow in the undesirable reverse direction and encourages the reestablishment of a normal thermosyphon cooling loop flow quickly following the termination of a thermal transient such as that caused by transmission line faults. The present invention requires no moving parts and may therefore be permanently sealed in the superconducting rotor without risk of costly repair efforts caused by components failure.

1982-12-21

469

Damage to rotor blades in axial steam turbines

The failure took place on a welded elbow pipe which exhibited a catastrophic transverse rupture. The failure was located on the welding HAZ region, parallel to the welding path. Branching cracks were detected at the edge of the rupture area. Deposits of corrosion products were also spotted. The optical microscope analysis showed the presence of transgranular failures which were related to the stress corrosion cracking (SCC) and were predominantly caused by the welding residual stress. The significant difference in hardness between the welded area and the pipe confirmed the findings. Moreover, the failure was also caused by the low Mo content in the stainless steel pipe which was detected by means of spark emission spectrometer. (orig.)

2010-08-15

470

CT findings of foreign bodies in the chest: a pictorial essay

A statistical evaluation of rotor blade damage in axial steam turbines affords an insight into the extent of the repair costs incurred and reveals the types of defects and shortcomings which cause such damage. The great amount of rotor blade damage discovered during control inspections will surprise even many turbine experts. The statistical evaluation is followed by a review of the more frequent causes of damage and their characteristic features, illustrated on the basis of practical examples. This contribution is intended as an aid to both the manufacturers and operators of steam turbines in preventing the oft almost classic types of faults which constantly recur. (orig.).

471

Analysis on Fault for the Underground Cable Systems at Home

The most common causes of tracheobronchial foreign bodies are peanuts in children, and meat and dentures in adults. The most common causes of esophageal foreign bodies are coins in children and meat in adults. It is passable to diagnose a foreign body by visualization on a chest radiograph, if the foreign bodies are radio opaque. However, if the foreign bodies are radiolucent and the patients do not remember the history of aspiration, it is important to evaluate CT findings for foreign bodies and their complications. We describe the CT findings of various thoracic foreign bodies in children and adults.

2008-05-15

472

Analysis of beam emittance in FEL (Free Electron Laser)

Many power apparatus and underground cable systems have been constructed since 1970 in korea. Recently, as the needs for underground T and D systems increase rapidly, any fault on the systems causes enormous economic losses in our society. Thus, this paper described. (1) Survey on the amount and the increasing rates of the underground cable systems at home and abroad. (2) Survey on fault data for the underground cables and joints at home and abroad.From the analysis on fault data, we analyzed the cause of fault and classified the typical fault mode for the underground cable systems. (author). 5 refs., 3 figs., 11 tabs.

1999-05-01

473

A Covered Nitinol Stent Fracture in a Patient with a Malignant Esophageal Stricture: A Case Report

To achieve high efficiency for the conversion of electron kinetic energy in an electron beam to electromagnetic energy in a Free Electron Laser (FEL), it is important to improve the beam quality. And hence, it is necessary to study and minimize the emittance growth of the beam. According to the requirements for the beam quality in an FEL, the author analyzed the emittance growth caused by the jump of the electric field in an accelerator, energy increase, wakefield in a waveguide, space charge effect and distribution of particles in a beam as well as the wakefield in a deflect system etc. The author also estimated the emittance change caused by the variation of the microwave field from the gun to the first accelerator for such case.

474

The role of high-resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) in the diagnosis of preoperative and postoperative complications caused by acquired cholesteatomas

Self-expanding metallic stent insertion has been widely applied for the palliative treatment of malignant esophageal strictures. Although it is known as an easy, safe, and effective procedure, complications are well known and include things such as stent migration and esophageal stent occlusion caused by tumor in growth. However, metallic stent fractures have been rarely reported in the esophagus, especially for nitinol stents. We report a case of a stent fracture associated with migration in a patient with a malignant esophageal stricture near the gastroesophageal junction. It is highly probable that the stent fracture was due to chemical erosion of the stent caused by gastric juice

2008-11-15

475

Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease

The role of high-resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) in the diagnosis of preoperative and postoperative complications caused by acquired cholesteatomas will be described in this paper. The pre- and postoperative imaging of the temporal bone was performed with HRCT and MRI. HRCT and MRI were performed in the axial and coronal plane. MRI was done with T2 weighted and T1 weighted sequences both before and after the intravenous application of contrast material. All imaging findings were confirmed clinically or surgically. The preoperative cholesteatoma-caused complications depicted by HRCT included bony erosions of the ossicles, scutum, facial canal in the middle ear, tympanic walls including the tegmen tympani, and of the labyrinth. The preoperative cholesteatoma-caused complications depicted by MRI included signs indicative for labyrinthitis, and brain abscess. Postoperative HRCT ...

2003-03-01

476

Studies on the mechanism of action of enterotoxin-induced fluid secretion in the gut

Outbreaks of disease attributable to human error or natural causes can provide unique opportunities to gain new information about host-pathogen interactions and new leads for pathogenesis research. Poststreptococcal glomerulonephritis (PSGN), a sequela of infection with pathogenic streptococci, is a common cause of preventable kidney disease worldwide. Although PSGN usually occurs after infection with group A streptococci, organisms of Lancefield group C and G also can be responsible. Despite decades of study, the molecular pathogenesis of PSGN is poorly understood. As a first step toward gaining new information about PSGN pathogenesis, we sequenced the genome of Streptococcus equi subsp. zooepidemicus strain MGCS10565, a group C organism that caused a very large and unusually severe epidemic of nephritis in Brazil. The genome is a circular chromosome of 2,024,171 bp. The genome shares extensive gene content, including many ...

2008-08-21

477

Electron-optical microscopic study of incipient dental microdamage from experimental seed and bone crushing

The mechanism of action of Clostridium difficile enterotoxin A (CA), of Escherichia coli enterotoxin (STa) and of cholera toxin (CT), which are known to cause severe diarrhea, were studied in a preparation of ligated jejunal loops of anesthetized rats in vivo. The toxins were administered intraluminally. Pharmacological agents, which were tested for their potency to influence toxin-related effects, were administered subcutaneously. Net fluid transport was determined gravimetrically, prostaglandin (PG) E_2-output into the lumen, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) contents in the mucosa were measured by radioimmunoassay, serotonin-(5-HT)-output into the lumen was determined by high performance liquid chromatography. The histopathological effects of CA and CT were examined by light- and scanning electron microscopy. All three toxins caused net fluid secretion (FS). 5-HT_2-(ketanserin) and ...

1992-01-01

478

Ultraviolet radiation for the sterilization of contact lenses

No living analogue exists for the hypothetical early hominid hard/tough-seed, coarse-root-eating, and bone-crushing masticatory adaptation. To investigate possible microdamage/microwear to dental enamel caused by such usage, puncture-crushing experiments were carried out on single human teeth, using an Instron compression apparatus on the following six test materials: Makapansgat Limeworks chert (e.g., taphonomy), fresh steer longbone, mongongo nuts, Grewia berries, Carob beans, and wild-onion bulbs. Pairs of extracted unworn third molars were utilized, with one tooth acting as the control. The teeth were mounted, ultrasonically cleaned, and two-stage replicas made with a vinyl polysiloxane elastomer and araldite epoxy resin. After Instron loading and materials failure (1.2-395.0 kg) the test items and the crowns were prepared for comparison with scanning electron microscopy and dispersive x-ray elemental analysis and mapping. The results revealed that although ...

1982-03-01

479

Ultraviolet radiation for the sterilization of contact lenses

Two sources of ultraviolet (UV) radiation with peak wavelengths in the UV-C or UV-B ranges were compared for their ability to sterilize contact lenses infected with Pseudomonas aeruginosa, Streptococcus pneumoniae, Acanthamoeba castellani, Candida albicans, and Aspergillus niger. Also examined was the effect of prolonged UV light exposure on soft and rigid gas permeable (RGP) contact lenses. The UV-C lamp (253.7 nm, 250 mW/cm2 at 1 cm) was germicidal for all organisms within 20 minutes but caused destruction of the soft lens polymers within 6 hours of cumulative exposure. UV-C caused damage to RGP lenses in less than 100 hours. The UV-B lamp (290-310 nm, 500 mW/cm2 at 1 cm) was germicidal for all organisms tested (except Aspergillus) with a 180-minute exposure and caused less severe changes in the soft lens polymers than did the UV-C lamp, although cumulative exposure of 300 hours did substantially weaken the soft lens ...

1990-10-01

480

The Polytechnique, UQAT, NSERC chair in environment and tailings management; La Chaire Polytechnique, UQAT, CRSNG en environnement et gestion des rejets miniers

Two sources of ultraviolet (UV) radiation with peak wavelengths in the UV-C or UV-B ranges were compared for their ability to sterilize contact lenses infected with Pseudomonas aeruginosa, Streptococcus pneumoniae, Acanthamoeba castellani, Candida albicans, and Aspergillus niger. Also examined was the effect of prolonged UV light exposure on soft and rigid gas permeable (RGP) contact lenses. The UV-C lamp (253.7 nm, 250 mW/cm2 at 1 cm) was germicidal for all organisms within 20 minutes but caused destruction of the soft lens polymers within 6 hours of cumulative exposure. UV-C caused damage to RGP lenses in less than 100 hours. The UV-B lamp (290-310 nm, 500 mW/cm2 at 1 cm) was germicidal for all organisms tested (except Aspergillus) with a 180-minute exposure and caused less severe changes in the soft lens polymers than did the UV-C lamp, although cumulative exposure of 300 hours did substantially weaken the soft lens ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

481

Studies of the behaviour of technical chemicals introduced into the subsoil under modelled conditions

The purpose of this new industrial chair is to ensure the continuation and development of new research activities in the field of environment protection as it relates to the good management of mine tailings. The mining industry plays a vital role in the economy of a number of regions in both Quebec and Canada and also causes environmental problems due to the generation of liquid, solid, and gaseous wastes. Mine tailings can cause acid mine drainage. This acid mine drainage (AMD) can have detrimental effects on the ecosystems adjoining tailings or waste rock piles. We must remain aware that some of the remedial measures instituted to contain AMD might cause problems due to their possible instability. Despite the fact that instability is a rare occurrence, it can have disastrous effects on the environment as demonstrated in Spain, Guyana, and the Philippines during the last few years. The creation of this chair in environment ...

2000-07-01

482

Oscillation diagnosis of steam turbines; Schwingungsdiagnose bei Dampfturbosaetzen

Because of the environmental hazard of organic solvents such as chlorinated or aromatic hydrocarbons, water soluble and biodegradable substitutes have come into use. It should be assessed how they affect soil and aquifer when spilled in leaks or accidents. This was simulated in a model system using methanol and percolation columns, one filled with material from the unsaturated subsurface and two with different materials from aquifers. The results reveal that a spill of the substitutes can also cause problems. In homogeneous soils and at long retention times until the substance reaches the aquifer, sorption and biological degradation are most likely to prevent contamination of the groundwater. When oxygen supply in the subsurface is insufficient, reducing conditions occur and sulphide is formed. The data show that much more methanol was eliminated than reflected by the consumption of electron acceptors. This indicates that sorption and anabolic turnover of the ...

1993-04-01

483

Origin and spread of a common deletion causing mucolipidosis type II: insights from patterns of haplotypic diversity

Modern oscillation- and analysis systems are often mentioned in the context of oscillation diagnosis which implies that this is a method of establishing the causes of the mechanical changes that cause the unwanted oscillation. Experience shows, however, that oscillation monitoring instruments can merely indicate oscillation symptoms at an early point in time. These findings must be interpreted in a machine-specific way and seen in the context of previous developments in order to establish the mechanical root cause of the matter. A 1000 MVA-generator shows that conventional oscillation measuring systems may also serve for diagnostic purposes within certain limits.(orig.) [German] Im Zusammenhang mit modernen Schwingungsmess- und Analysensystemen wird haeufig der Begriff der Schwingungsdiagnose verwandt und inpliziert, damit auch die Ursache von mechanischen Veraenderungen finden zu koennen, welche das beanstandete ...

1998-07-01

484

British Library Electronic Table of Contents (United Kingdom)

Coutinho MF, Encarnao M, Gomes R, da Silva Santos L, Martins S, Sirois-Gagnon D, Bargal R, Filocamo M, Raas-Rothschild A, Tappino B, Laprise C, Cury GK, Schwartz IV, Artigals O, Prata MJ, Alves S. Origin and spread of a common deletion causing mucolipidosis type II: insights from patterns of haplotypic diversity. Mucolipidosis II (ML II alpha/beta), or I-cell disease, is a rare genetic disease in which activity of the uridine diphosphate (UDP)-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-phosphotransferase) is absent. GlcNAc-phosphotransferase is a multimeric enzyme encoded by two genes, GNPTAB and GNPTG. A spectrum of mutations in GNPTAB has been recently reported to cause ML II alpha/beta. Most of these mutations were found to be private or rare. ...

2011-01-01

485

Oil pipeline valve automation for spill reduction

Historical overview of wound ballistics research.

Liquid pipeline codes generally stipulate placement of block valves along liquid transmission pipelines such as on each side of major river crossings where environmental hazards could cause or are foreseen to potentially cause serious consequences. Codes, however, do not stipulate any requirement for block valve spacing for low vapour pressure petroleum transportation, nor for remote pipeline valve operations to reduce spills. A review of pipeline codes for valve requirement and spill limitation in high consequence areas is thus presented along with a criteria for an acceptable spill volume that could be caused by pipeline leak/full rupture. A technique for deciding economically and technically effective pipeline block valve automation for remote operation to reduce oil spilled and control of hazards is also provided. In this review, industry practice is highlighted and application of the criteria for maximum permissible ...

2003-07-01

486

Heat transfer augmentation around a downward-facing flat plate by non-uniform electric fields

Ballistics involves the study of the scientific properties of projectiles, their behavior and their terminal effects on biological tissues and other materials. Wound ballistics deals with the analysis of injuries caused by projectiles and the behavior of projectiles within human or other biological tissues. The nineteenth century witnessed the development of both of these areas with Kocher's hydrodynamic theory and the understanding of the significance of bullet deformation in causing tissue injury. The degree of traumatic disruption of tissues and organs was also related to direct energy transfer from projectiles. While subsequent research has concentrated on elucidating further mechanisms of injury, the exact cause of remote tissue damage from high energy projectiles is still the subject of ongoing research. Much of the contemporary literature regarding wound ballistics concentrates on the forensic aspects and their ...

2009-05-23

487

HC cylinder to cylinder deviation at idling condition in a direct injection diesel engine. Chokusetsu funshashiki diesel kikan mufuka untenji no HC kitokan hendo

The corona wind caused by nonuniform electric fields has been experimentally reported so far to be effectively applicable to heat transfer augmentation. In this paper, first, a theoretical and experimental study has been conducted to make clear such a mechanism of augmentation of heat transfer to a downward-facing flat plate due to a nonuniform electric field caused by a fine wire anode and a plate cathode as that ions produced near the wire electrode move to the plate introducing the bulk convective motion of fluid caused by collision of ions and neutral molecules. Secondly, experiments have been carried out by using twin and multi-wire electrodes and the plate to find the augmentation performance of heat transfer for the number and the arrangement of the wire electrodes, to explain the performance from the electrohydrodynamical standpoint based on the theoretical investigation and to obtain important and fundamental data ...

1978-08-11

488

Gene linked to Lou Gehrig's disease

Causes of variation of hydrocarbon (HC) concentration in cylinder to cylinder at idling condition in a direct injection diesel engine were studied. The ratio of l/d=6 gives larger HC variation in cylinder to cylinder than the l/d=2, where l means the nozzle hole length and d means the nozzle hole diameter. This is because the condition of l/d=6 can result in the large spray penetration and increase the fuel on the combustion chamber. The spray structure changes between nozzles and also changes between nozzle holes. This is not caused by the shape of nozzle hole but is affected by the pressure change near the inlet of nozzle hole when the needle valve is lifted. The change of spray structure can change the injection volume between nozzle holes. The injection volume is less for a nozzle hole where the curved angle becomes sharp to the nozzle central angle, and is more at the opposite side. When the injection volume of the nozzle hole near the ...

1992-07-01

489

Emergency core cooling device

Scientists have just taken a big step toward understanding the cause of Lou Gehrig's disease, one of the most devastating nerve degenerative diseases. A large team of researchers, led by Robert Brown Jr. of Harvards's Massachusetts General Hospital and Robert Horvitz, a Howard Hughes Medical Institute investigator at the Massachusetts Institute of Technology, report in the 4 March Nature that they've identified the gene that causes a hereditary form of the condition, which also goes by the name amyothophic lateral sclerosis (ALS). While most ALS cases - approximately 90% - are apparently sporadic' and not caused by an inherited gene defect, all the patients have such similar symptons that researchers are hopeful that what they learn about hereditary ALS will also apply to the sporadic form, possibly leading to new therapeutic strategies that will help both. It's a very important ...

1993-03-05

490

Corrosion failure and its prevention in light water reactor power plants

In an existent emergency reactor core cooling device, if a ruptures should occure in a pipeline of a gravitational dropping type reactor core cooling system pool (GDCS) due to some or other causes, a portion of GDCS pool water was flown out of the ruptured port and could not be used for reactor core cooling. Then, a difference pressure detector is disposed to a GDCS pipeline at the inlet of a reactor pressure vessel. When it is judged by the detector, that coolants flow to the outside of the injection pipeline, an injection value disposed to the GDCS pipeline is closed by the difference pressure signal. Even if a rupture should occur on the side of the pressure vessel at downstream to the check value of the GDCS pipeline, since backflow is caused at the pressure container inlet of the GDCS pipeline with the rupture port, the rupture is detected by the difference pressure detector to close the injection valve. Therefore, loss of the GDCS pool ...

1990-10-29

491

Corrosion failure and its prevention in light water reactor power plants

During 17 years since the start of operation of the first commercial LWR in Japan, many LWRs have experienced various corrosion damages, but the causes of them were clarified, and the counter-measures were executed effectively in actual plants, as the results, the cause of corrosion damage decreased remarkably, and now, the high rate of operation has become to be maintained. In this paper, the major cases of corrosion damage experienced in LWRs in Japan and foreign countries, the causes of them and the countermeasures, the problems of hereafter and so on are described. The corrosion damage of metallic materials in the environment of LWRs occurs in the parts in contact with high temperature, high pressure water and steam, such as stainless steel piping in the primary cooling system of BWRs, and nickel alloy heating tubes of steam generators, carbon steel feed water piping and zirconium alloy fuel cladding tubes in PWRs. ...

1988-01-01

492

Anti-muscarinic actions of mitoxantrone in isolated heart muscles of guinea pigs.

During 17 years since the start of operation of the first commercial LWR in Japan, many LWRs have experienced various corrosion damages, but the causes of them were clarified, and the counter-measures were executed effectively in actual plants, as the results, the cause of corrosion damage decreased remarkably, and now, the high rate of operation has become to be maintained. In this paper, the major cases of corrosion damage experienced in LWRs in Japan and foreign countries, the causes of them and the countermeasures, the problems of hereafter and so on are described. The corrosion damage of metallic materials in the environment of LWRs occurs in the parts in contact with high temperature, high pressure water and steam, such as stainless steel piping in the primary cooling system of BWRs, and nickel alloy heating tubes of steam generators, carbon steel feed water piping and zirconium alloy fuel cladding tubes in PWRs. ...

493

Risk assessment for radiation protection purposes

A hypotheses that mitoxantrone is a competitive antagonist at muscarinic cholinergic receptors was examined in guinea-pig hearts. In isolated left atrial muscle preparations, electrically paced at 2 Hz, the muscarinic agonist, carbachol, caused a concentration-dependent decrease in developed tension. Mitoxantrone caused a parallel right-ward shift of the concentration-response curve for carbachol. Schild plots for the effect of mitoxantrone on the carbachol concentration-response relationship were linear with a slope of 0.88 which was not significantly different from the unity. The right-ward shift of the carbachol concentration-response relationship by mitoxantrone significantly reversed after an additional incubation with a mitoxantrone-free solution, although the reversal was incomplete after a 2-h incubation in the mitoxantrone-free solution. Mitoxantrone caused a concentration-dependent displacement of specific ...

2000-10-27

494

Influence of pollution abatement measures on the evaluation of air pollution caused by heating systems with special regard to the costs involved. Einfluss von emissionsmindernden Massnahmen auf die Schadstoffbewertung der Heizsysteme unter Beruecksichtigung der damit verbundenen Kosten

In defining criteria for good protection against ionizing radiation, it is important to assess quantitatively the likely risk of any radiation exposure. The 'somatic' risks to the individual result mainly from induction of cancer in the organs irradiated, and these risks can now be estimated on the basis of numerous detailed epidemiological surveys of exposed human populations. Estimates of the risk of hereditary effects, from genetic changes induced in germ cells, are based largely on the frequency with which such effects are induced in other species. In both cases the risk at very low dose can be inferred using knowledge of the way in which radiation damage is caused in tissues. Coherent systems of radiation protection are based on a restriction of doses to the whole body and to individual organs, such that the induction of cancer and genetic harm is infrequent, and the threshold dose for causing other, 'non-stochastic', effects is not ...

1980-01-01

495

Immune responses induced by spirochetal outer membrane lipoproteins and glycolipids

Apart from presenting the marginal legal conditions the research program contains a brief description of current pollution abatement measures, representative heating systems and individually suitable pollution abatement technologies and an account of the determination of the concentration of major pollutants. The comparative evaluation of heating systems assesses their environmental effects, i.e. air pollution caused by heating systems. The determination of the costs of available heat is followed by an overall evaluation of the results obtained with special regard to the costs involved by pollution abatement measures.

1986-01-01

496

British Library Electronic Table of Contents (United Kingdom)

The class of Spirochetes comprises a wide array of clinically important pathogens, including Treponema pallidum causing syphilis as well as Borrelia burgdorferi, the agent of Lyme disease (LD). Diseases caused by spirochetes are characterized by specific sequelae of host reactions, and also by characteristic antibody response patterns. Over the last decades, research on the interaction of spirochetes with the hosts immune system had a strong emphasis on outer membrane lipoproteins. In fact, these structures have been convincingly shown to activate immune cells via CD14 and Toll-like receptor (TLR)-2, and recent data also indicate an interaction with lipopolysaccharide (LPS)-binding protein (LBP). In particular, the interaction of B. burgdorferi with TLR-2 could not only be demonstrated in ...

2008-01-01

497

Human papillomavirus: science and technologies for the elimination of cervical cancer

British Library Electronic Table of Contents (United Kingdom)

Introduction: Academic research has made a significant advancement in understanding the viral causes of cervical cancer and generating the technology for prevention, both at the primary and secondary levels. Human papillomaviruses (HPVs) have been recognized as the first necessary cause of cervical cancer, the second most common cancer in women worldwide. Areas covered: This paper reviews the epidemiological evidence of the causality of HPV in relation to cervical cancer, other genital tract cancers and some cancers of the oral cavity and oropharynx. The review also covers HPV DNA testing as a screening tool. DNA probes of high-risk HPV types in different formats have been fully validated as primary screening tests, as secondary triage tests and as a prognostic marker following treatment o...

2011-01-01

498

Charles Darwin and the Evolution of Human Grammatical Systems

British Library Electronic Table of Contents (United Kingdom)

Charles Darwin's evolutionary theories of animal communication were deeply embedded in a centuries-old model of association psychology, whose prodromes have most often been traced to the writings of Aristotle. His notions of frequency of occurrence of pairings have been passed down through the centuries and were a major ontological feature in the formation of associative connectivity. He focused on the associations of cause and effect, contiguity of sequential occurrence, and similarity among items. Cause and effect were often reduced to another type of contiguity relation, so that Aristotle is most often evoked as the originator of the associative bondings through similarity and contiguity, contiguity being the most powerful and frequent means of association. Contiguity eventually became ...

2010-01-01

499

A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies

British Library Electronic Table of Contents (United Kingdom)

Abstract One of the most significant problems in industrial bioprocessing of recombinant proteins using engineered mammalian cells is the phenomenon of cell line instability, where a production cell line suffers a loss of specific productivity (qP). This phenomenon occurs with unpredictable kinetics and has been widely observed in Chinese hamster ovary (CHO) cell lines and with all commonly used gene expression systems. The underlying causes (both genetic and physiological) and the precise molecular mechanisms underpinning cell line instability have yet to be fully elucidated, although recombinant gene silencing and loss of recombinant gene copies have been shown to cause qP loss. In this work we have investigated the molecular mechanisms underpinning qP instability over long-term sub-cult...

2011-01-01

500

A future of floods?; Droht Land unter?