BackgroundThe presence of enthesitis (insertional inflammation) in patients with juvenile idiopathicarthritis (JIA) is difficult to establish clinically and may influence classification...Full Text Available
IntroductionPrevious observations suggest that active systemic juvenile idiopathicarthritis (sJIA) is associated with a prominent erythropoiesis gene-expression signature. The aim...Full Text Available
BackgroundNo consensus evidence-based guidelines for the routine laboratory monitoring of children with JIA receiving non-steroidal anti-inflammatory drugs (NSAIDs) exist. The purpose...Full Text Available
Purpose. To describe the characteristics of idiopathic macular holes (MH) on optical coherence tomography (OCT) and correlate OCT with clinical assessment. Design....Full Text Available
Congenital isolated pleural effusion is a rare cause of respiratory distress in neonates. It is usually chylous. Herein, we report a rare case of nonchylous congenital idiopathic pleural effusion.
Idiopathic achalasia is a primary esophageal motor disorder characterized by esophageal aperistalsis and abnormal lower esophageal sphincter (LES) relaxation in response to deglutition. It is a rare...Full Text Available
Type II collagen-induced arthritis (CIA) in mice is an autoimmune experimental model for rheumatoid arthritis. Susceptibility to CIA is associated with certain major histocompatibility complex class...Full Text Available
Rheumatoid arthritis (RA) is a debilitating autoimmune disease of global prevalence. The disease is characterized by synovial inflammation leading to cartilage and bone damage. Most of the conventional...Full Text Available
According to the International Headache Society, idiopathic stabbing headache (ISH), an indomethacin-responsive headache syndrome, is a paroxysmal disorder of short duration manifested as head pain...Full Text Available
During the past decade idiopathic venous thromboembolism has become a separate entity, a chronic illness which has required prolonged anticoagulation and other prevention strategies to avoid recurrences....Full Text Available
ObjectiveTo report the efficacy and safety of combined photodynamic therapy (PDT) and intravitreal bevacizumab (IVB) injection in the treatment of idiopathic polypoidal choroidal...Full Text Available
The abnormal megakaryocytopoiesis associated with idiopathic myelofibrosis (IM) plays a role in its pathogenesis. Because mice with defective expression of transcription factor GATA-1 (GATA-1low...Full Text Available
The author presents his impressions of the conference - that is - major lessons as presented in the talks on nonlinearities and their role in condensed matter physics. (WRF)
Low dose methotrexate has been used effectively for various rheumatic and non-rheumatic diseases. Three cases of Pneumocystis carinii pneumonia occurring during treatment of rheumatoid arthritis with...Full Text Available
BackgroundThe precise mechanisms involved in the initiation and progression of rheumatoid arthritis (RA) are not known. Early stages of RA often have non-specific symptoms, delaying...Full Text Available
OBJECTIVE: To examine primary care physicians' management of rheumatoid arthritis, ascertain the determinants of management and compare management with that recommended by a current practice panel....Full Text Available
The localization of gold in the synovial membrane of rheumatoid arthritis patients treated with sodium aurothiomalate was examined and quantitative analysis of epon-embedded sections was carried out...Full Text Available
A lentivirus was isolated from 2 goats in Mexico that were seropositive to caprine arthritis encephalitis virus (CAEV) by the agar gel immunodiffusion (AGID) test. The lentivirus was identified as CAEV...Full Text Available
We describe two cases of septic arthritis occurring in association with lower urinary tract infection in elderly men. In both cases the organism isolated from both the joint and the urine was Staphylococcus...Full Text Available
Objective:To investigate the combined effect of both pioglitazone and methotrexate on disease activity of rheumatoid arthritis in a biphasic study; experimental and clinical.Methods:Experimentally:...Full Text Available
Of 400 patients with brucellosis, 104 (26%) had arthritis, of whom 96 could be followed up. The systemic disease in the 96 patients was acute in 54 (56%), subacute in 24 (25%), and chronic in 18 (19%)....Full Text Available
Objectives: To report six month outcome in patients undergoing their first pulmonary vein ablation procedure for idiopathic atrial fibrillation (AF) at a “non-pioneering”...Full Text Available
Idiopathic frozen shoulder is a common medical diagnosis for patients seeking physical therapy. Radiographic and surgical evidence exists that describes the coracohumeral ligament (CHL) as a major contributor...Full Text Available
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor survival. The identification of therapeutic targets is essential to improving outcomes. Previous studies found that expression...Full Text Available
Idiopathic or functional abdominal pain (FAP) is common in school-age children and typically reflects a functional gastrointestinal disorder (FGID). FGIDs in adults have been distinguished by...Full Text Available
Psychological illness influences the experience and expression of pain and disability. We tested three null hypotheses: (1) patients with nonspecific pain (medically unexplained and idiopathic) and...Full Text Available
BackgroundThe aim of this study was to provide more insight into the question as to why blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid arthritis...Full Text Available
The European Union's proposed multinational market in carbon dioxide emissions faces many design challenges. Helpful lessons could be learnt from the US experience of trading nitrogen oxide allowances. 2 figs.
A range of lessons have been identified from previous attempts to implement long term radioactive waste management policy in the UK and internationally. Many of these relate to the way the decision-making process is undertaken and the fact that there needs to be an open, transparent process that enables continuous stakeholder involvement. Nirex believes that using the SEA and EIA frameworks will help to incorporate the lessons learned into the future decision-making process relating to long-term radioactive waste management.
Accidents from three main practices: medical applications, industrial radiography and industrial irradiators are used to illustrate some common causes of accidents and the main lessons to be learned. A brief description of some of these accidents is given. Lessons learned from the described accidents are approached by subjects covering: safety culture, quality assurance, human factors, good engineering practice, defence in depth, security of sources, safety assessment and monitoring and verification compliance. (author)
Idiopathic pulmonary fibrosis is the most lethal form of diffuse lung fibrosis, killing approximately half of those affected within 2-3 years of diagnosis. Until recently, no therapies had been shown to have an impact on disease progression. The Clinical Studies Assessing Pirfenidone (Esbriet) in IPF: Research of Efficacy and Safety Outcomes (CAPACITY) program comprised two almost identical double-blind placebo-controlled studies assessing the effects of pirfenidone on change in forced vital capacity, the primary end point, over a 72-week period. One of these studies was positive, matching in magnitude the benefit seen in two previous positive Japanese studies. The other study did not meet its primary end point but positive trends were consistent in this and a number of secondary end point...
There is ample evidence suggesting that superantigens may act as a triggering factor in the pathogenesis of rheumatoid arthritis (RA). We investigated whether superantigen could activate T cells in...Full Text Available
BackgroundCelecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration of celecoxib...Full Text Available
ObjectivesTo investigate the effect of group cognitive behavioural therapy (CBT) for fatigue self-management, compared with groups receiving fatigue information alone, on fatigue...Full Text Available
Indomethacin, a potent nonsteroidal anti-inflammatory drug, has been used in the treatment of various kinds of pains, inflammation and arthritis. However, oral administration of indomethacin produces...Full Text Available
Information from the Health Assessment Questionnaire (HAQ) is used to identify which variables measured in 1981 successfully predict the severity of disease in 1989 and the eight year change in severity...Full Text Available
Isometric/isokinetic muscle strength and isokinetic endurance of the lower extremities as well as aerobic capacity were evaluated in 67 patients (43 female, 24 male; mean age 53 years, range 23-65)...Full Text Available
Multiglycosides of Tripterygium wilfordii Hook f (GTW), a Chinese herb-derived medicine used as a remedy for rheumatoid arthritis, are considered to be a reversible anti-fertility drug...Full Text Available
BackgroundSulfasalazine is a widely used anti-inflammatory agent in the treatment of inflammatory bowel disease and several rheumatological disorders. Although as many as 20% of...Full Text Available
ObjectiveTo evaluate the effect of different concomitant disease modifying antirheumatic drugs (DMARDs) on the persistence with antitumour necrosis factor (anti-TNF) therapies in...Full Text Available
Random forest (RF) analysis of genetic data does not require specification of the mode of inheritance, and provides measures of variable importance that incorporate interaction effects. In this paper...Full Text Available
BackgroundLeukotrienes (LTs) belong to the large family of lipid mediators implicated in various inflammatory conditions such as asthma and rheumatoid arthritis. Four distinct types...Full Text Available
IntroductionBRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known...Full Text Available
IntroductionThe goal of this study was to identify serum markers that are modulated by treatment with golimumab with or without methotrexate (MTX) and are associated with clinical...Full Text Available
In China, Korea, and Japan, a decoction of the dried root without bark of Paeonia lactiflora Pall. has been used in the treatment of rheumatoid arthritis, systemic lupus erythematosus,...Full Text Available
Twenty rheumatoid arthritis (RA) patients with involvement of the cranio-cervical junction (CCJ) were given CT scan. In most cases the myelo-CT technique with the lumbar injection of small quantities of non-ionic contrast medium was adopted; CT easily diagnosed the horizontal and vertical dislocations on the CCJ, the bone strcture lesions and the inflammatory masses. A high frequency of medullary compressions was also found in these patients. Myelo-CT appears to be the technique of choice for the precise definition of the various factors responsible for the neurological complications found in RA of the CCJ.
Purpose:To report the preoperative best-corrected visual acuity (BCVA) and foveal thickness (FT) values that lead to a postoperative decimal BCVA of ≥1.0 after surgical removal...Full Text Available
ObjectiveTo evaluate the primary care communications initiative, which introduced NHSnet to primary care in Scotland.DesignSemi-structured telephone...Full Text Available
... Abstract : Iraqi armored and mechanized divisions crossed the border of ... quick response, the first elements of the 82nd Airborne Division arrived in ...
A historical account of the important landmarks in man's experience with the high altitude environment is followed by comments on the important stages in the understanding of its physiological effects....Full Text Available
Adjuvant-induced arthritis in rats is a chronic inflammatory disease, widely as an animal model for rheumatoid arthritis. In our study the effect of various fractions of dialyzable leukocyte extract (DLE): DLE I-molecular weight below 10 kDa (commercial preparation), DLE II-molecular weight below 5 kDa (suppressor fraction), DLE III-molecular weight 5-10 kDa on rat adjuvant-induced arthritis was studied. The adjuvant arthritic (AA) rats were treated with DLE fractions i.p. in solutions containing an active substance isolated from 12.5 x 10{sup 6} and 6.25 x 10{sup 6} leukocytes from day 1 (adjuvant injected) through day 18, every second day (total 9 times). Various markers in inflammation, immune function and joint destruction were evaluated: hind paw volume, serum hyaluronic acid, serum albumin and biopterin in urine. All these markers showed a significant improvement after using fraction DLE II in comparison with AA ...
Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This leads to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate "1"6"6Ho-Hydroxyapatite ("1"6"6 Ho-HA) as potential radiopharmaceutical for the symptomatic treatment of chronic and acute arthritis. Materials and Methods: Holmiun-166 was produced by irradiation of Ho_2O_3 at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthesized. Its labelling and quality controls follows the internationally accepted procedures. An antigen's arthritis was induced to eight New Zealand rabbits with the "1"6"6 Ho-HA radiochemical being administered thereafter in two dosage modalities (single and double). The compound therapeutic ...
The increasing number of hazardous materials accidents in the United States has resulted in new federal regulations addressing the emergency response activities associated with chemical releases. A significant part of these new federal standards (29 CFR 1910.120 and 40 CFR Part 311) requires compliance with specific criteria by all personnel involved in a hazardous material emergency. This study investigated alternative lesson design models applicable to instruction for hazardous material emergencies. A specialized design checklist was created based on the work of Gagne, Briggs, and Wager (1988), Merrill (1987), and Clark (1989). This checklist was used in the development of lesson plan templates for the hazardous materials incident commander course. Qualitative data for establishing learning objectives was collected by conducting a needs assessment and a job analysis of the incident commander position. Incident commanders from 14 public and ...
Because toxicity with the use of 3000 centiGray (cGy) of total lymphoid irradiation (TLI) was observed in an earlier study, 2000-cGy treatments were delivered in a 2-portal format to 7 patients and in a modified 3-portal fashion to 6 patients, as part of a randomized, investigator-blinded trial of TLI treatment for refractory rheumatoid arthritis. Analysis of combined data from the 13 patients revealed statistically significant improvement in 5 clinical indicators of disease activity at the end of TLI and 6 and 12 months later, accompanied by T4-specific immunosuppression. Management considerations resulted in the introduction of prednisone therapy in 5 patients, methotrexate in 4, and azathioprine in 1 during the interval of 8-12 months post-TLI. Herpes zoster occurred in 5 patients prior to the initiation of this additional therapy. These data indicate that, in patients with rheumatoid arthritis, a TLI dose of 2000 cGy is sufficient to ...
On November fourth and fifth 2010 a group of more than 100 international investigators gathered in Atlanta for the second Osteoarthritis (OA) Biomarkers Global Initiative workshop titled ''Genetics and Genomics: New Targets in OA''. The first workshop took place in April 2009 and focused on in vitro (soluble) biomarkers whilst the third and final workshop will take place in 2012 and will focus on imaging biomarkers. The OA Research Society International (OARSI) has organized the workshops. In addition to OARSI, the National Institute of Arthritis, Musculoskeletal and Skin Diseases, the Arthritis Foundation, Amgen, Genzyme, the American Orthopaedic Society for Sports Medicine and Pfizer sponsored the second meeting. It was clear from this meeting that experiments in the genetics, epigenetic...
To determine the proportion of rheumatoid arthritis (RA) patients receiving preventive health care according to US Preventive Services Task Force recommendations compared with a community-based population sample, with emphasis on dyslipidemia testing, given the increased risk of cardiovascular disease (CVD) in RA patients. Patients with RA (ICD-9 code 714.0 at ?2 office visits with a rheumatologist) and a primary care physician (PCP) at the Geisinger Health System (GHS) were identified through electronic health records. The records were searched back from 3/31/08 for the length of time required to satisfy each outcome measure. Percentages were compared with population testing rates using the Pearson Chi-square test. Eight hundred and thirty-one RA patients were compared to 169,476 subjects...
The aim of this review is to evaluate the role of inflammatory spine disease in patients with chronic back pain. The contribution of imaging modalities for the diagnostic evaluation of back pain is discussed. A systematic literature search based on the classification of seronegative spondyloarthropathies and rheumatoid arthritis was performed. The results of this search and the experiences in a large collective of rheumatological patients are analyzed. The prevalence of rheumatoid arthritis (1-2%) is comparable to that of spondyloarthropathies (1.9%). The etiology of these entities is not fully elucidated. Magnetic resonance imaging is increasingly used for early detection and surveillance of therapy with TNF-#alpha# antagonists. Bone marrow edema, which is only detectable with MRI, represents an early sign of inflammation. Therapy with TNF-#alpha# antagonists is based on clinical and laboratory criteria, and signs of inflammation in MRI. MRI ...
Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I-radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fluid than in simultaneously obtained serum. Many patients with gout or various other rheumatic diseases also had detectable anticollagen antibodies. With a few notable exceptions, the majority of the reactivity detected in all patient groups was directed against covalent structural determinants present on all of the denatured collagens, suggesting a secondary reaction to tissue injury.
The diagnosis of idiopathic pulmonary hemosiderosis (IPH) may be elusive. A 6-year-old boy had microcytic hypochromic anemia and a hemolytic component. Hemosiderin-laden macrophages were not found in the gastric aspirate. He had no pulmonary signs or symptoms. Extensive hematologic and roentgenologic investigations failed to reveal the cause of the anemia. Quantitative serial scintigraphic scanning showed significant (35%) pulmonary sequestration of autologous erythrocytes labeled with sodium chromate Cr51. The half-life of the RBCs was moderately decreased (half-life, 15 days; normal, 25 to 35 days). An open-lung biopsy spece Cr51. The half-life of the RBCs was moderately decreased (half-life, 15 days; normal, 25 to 35 days). An open-lung biopsy specimen confirmed the diagnosis of IPH. A diagnosis of IPH should be considered when children have iron deficiency anemia and pulmonary signs or symptoms. Organ sequestration studies may be helpful in equivocal cases.
A 1.5-year-old male Belgian Malinosis Military Working Dog presented with a 1-month history of intermittent hematuria. Diagnostic ultrasound and contrast radiography demonstrated large blood clots in the urinary bladder and a filling defect in the right renal pelvis. At surgery, clotted blood was present in the right ureter and bladder. Following right nephrectomy, the dog returned to training. One month later, elevations in urea nitrogen and creatinine were noted. Hematuria recurred at 3 months and the dog was found dead in its kennel. Necropsy showed a blood-filled left renal pelvis and ureter. PMID:1454185
We have previously described an allelic polymorphism in the V beta 6.1 T-cell receptor gene. The V beta 6.1B allele is associated with disease in a subgroup of patients with juvenile rheumatoid arthritis....Full Text Available
We have recently shown that viable Borrelia burgdorferi organisms induce a chronic infection associated with arthritis and carditis in severe combined immunodeficiency (scid) mice but not in immunocompetent...Full Text Available
We identified three patients (two of them relatives) with RA and signs of scleroderma whose sera contained a high titre of IgG class antibodies against the nucleoli and the nucleoplasm of cells of different...Full Text Available
Examines the effects of computer-based manufacturing technologies on employment opportunities and job skills. Describes the establishment of the Industrial Technology Institute in Michigan to develop and utilize advanced manufacturing technologies, and the institute's relationship to the state's community colleges. Reviews lessons learned from interinstitutional cooperation. Highlights future challenges. (DMM)
AbstractIndividual informed consent is a key ethical obligation for clinical studies, but empirical studies show that key requirements are often not met. Common recommendations to strengthen...Full Text Available
Neuroblasts born in the adult subventricular zone (SVZ) migrate long distances in the rostral migratory stream (RMS) to the olfactory bulbs where they integrate into circuitry as functional interneurons....Full Text Available
The kindling model of temporal lobe epilepsy and the memory model of long-term potentiation (LTP) may have common underlying mechanisms. This is evident by the demonstration that certain signaling...Full Text Available
IntroductionTerror attacks in Southeast Asia were almost nonexistent until the 2002 Bali bomb blast, considered the deadliest attack in Indonesian history. Further attacks in 2003...Full Text Available
Many lessons in autoimmunity — particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology — can be learned from the study of alopecia...Full Text Available
Conducting rigorous psychosocial intervention research with cancer patients has many challenges including encouraging them to join studies, asking them to engage in interventions or be part...Full Text Available
This paper summarizes the findings for the African Region of the WPA Task Force on Steps, Obstacles and Mistakes to Avoid in the Implementation of Community Mental Health Care. We present an overview...Full Text Available
Summary: The small DNA tumor viruses have provided a very long-lived source of insights into many aspects of the life cycle of eukaryotic cells. In recent years, the emphasis has been on cancer-related...Full Text Available
... Contact was broken at 1628 hours -n! f1r1 again at 1730 hours. ... wore_ 5 US KIA and 14 WI... 13 VC bexly count by air and ground tro~ps rusultod-. ...
Pumped storage plants 20 are a relatively common type.They use a dam to create an upper reservoir ...Some pumped storage plants use the same water turbine and electric generator for both operating periods.That is,
Pumped storage plants are a relatively common type.They use a dam to create an upper reservoir ...Some pumped storage plants use the same water turbine and electric generator for both operating periods.
BackgroundNorthern Uganda unlike other rural regions has registered high HIV prevalence rates comparable to those of urbanized Kampala and the central region. This could be due to...Full Text Available
Designed primarily for Missouri vocational agricultural instructors participating in the Farm Business Management Analysis Program, this instructor's guide, consisting of 10 lessons, deals with adjusting a farm business to increase profits. The following topics are covered in the individual lessons: law and the farm family, planning income tax management, closing the record book and planning cash flow, evaluating family living expenses, determining the most profitable livestock enterprise, determining the most profitable cropping system, planning the farm marketing program, adjusting capital investments to increase net profit, planning for efficient labor use, and controlling costs. Included in each section are suggestions for a review of previous materials covered, an objective, motivational techniques, key points to be addressed in the lesson, information to be introduced during the lesson, ...
While many lessons have been learned from the spatial analysis of cancer, there are several caveats that apply to many, if not all such analyses. As "flies in the ointment", these can substantially...Full Text Available
It is urged that the lesson of gauge invariance in quantum electrodynamics implies the irrelevance of `Schwinger term` difficulties in current algebra. The divergence equations of Veltman form the basis of a gauge-variation formalism in which these questions are avoided. (author). 9 refs.
Transgenic mouse models have contributed considerably to our understanding of the cellular and molecular mechanisms by which androgens control spermatogenesis. Cell-selective ablation of the androgen...Full Text Available
Background. Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs). The optimal hemoglobin,...Full Text Available
Failure of a dam is something we hope never happens. But if a failure occurs, it`s important to study the circumstances in order to expand our knowledge base, and then apply what we learn to other structures.
MILSTAR's Flexible Substrate Solar Array (FSSA) is an evolutionary development of the lightweight, flexible substrate design pioneered at Lockheed during the seventies. Many of the features of the design are related to the Solar Array Flight Experiment (SAFE), flown on STS-41D in 1984. FSSA development has created a substantial technology base for future flexible substrate solar arrays such as the array for the Space Station Freedom. Lessons learned during the development of the FSSA can and should be applied to the Freedom array and other future flexible substrate designs.
The major distributor and retailer of electrical power to Auckland, New Zealand, is Mercury Energy Limited. Following the sequential failure of the four 110kV underground cables, two gas-filled and two oil-filled, which supply the central business district, power was interrupted for 29 days from the 20th February 1998. A government inquiry was instituted, to examine what happened, why, and what lessons could be drawn for the future. Inadequacies in Mercury Energy`s cable maintenance and operating procedures were identified. The findings of the inquiry and its recommendations are reported. (UK)
Hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) is a genetic disorder with autosomal dominance, variable penetrance, and an estimated prevalence of 1/10,000 inhabitants in France. Diagnosis is based on clinical criteria including epistaxis, telangiectasia, visceral manifestations, and familial occurrence. Pulmonary arteriovenous malformations, present in 15-33% of patients, are its primary visceral complications. The disease may be revealed by infectious and ischemic neurological manifestations due to paradoxical embolism. The high frequency of neurologic complications even in asymptomatic patients justifies systematic screening for pulmonary arteriovenous malformations. Treatment of these malformations is based on percutaneous transcatheter coil embolization of the feeding artery. Pulmonary arterial hypertension is rare in this disease. It may be due to systemic arteriovenous shunting in the liver, which increases cardiac output, or be similar to ...
An asymptomatic pink discoloration of a maxillary right fourth premolar tooth was discovered during a routine oral examination on a 9 year-old Belgian Malinois dog. A radiolucent lesion was seen in the pulpal chamber on radiographic examination. The lesion had perforated the mesiobuccal root of the tooth. The primary differential diagnosis was idiopathic internal resorption. The tooth was treated by partial resection (removal of the mesiobuccal root and associated crown). A vital pulpotomy and amalgam restoration was performed on the remaining tooth structure. A follow-up 1 year later demonstrated a successful treatment outcome. The animal was asymptomatic and able to perform military duties. Clinical and radiographic signs of healing were evident and the tooth was functional. PMID:10518874
Introduction: Intractable ascites in neonates has a varied etiology; and often, the cause is idiopathic. The management usually consists of observation, diuretics, paracentesis, albumin replacements, and self correction. However, in some cases, the above treatment remains unsuccessful. Results: We present 2 cases of intractable ascites causing metabolic abnormalities, severe protein and immunoglobulin loss, and respiratory compromise. Although the use of peritoneovenous shunts for intractable ascites has been reported previously, our cases differ in both technique and patient size. Our first patient is an ex-28-week premature, 1.4-kg infant with intractable ascites for which a peritoneal drain was initially placed. After 3 weeks and putting out nearly 300 mL of ascitic fluid daily, we plac...
Spondylarthritides (SpA) and inflammatory bowel disease (IBD) are idiopathic, chronic inflammatory disorders. Although they are very distinct and well-defined entities, there is clinical and genetic evidence supporting some degree of overlap between the pathogenesis of the two. Subclinical gut inflammation is present in up to two thirds of all SpA patients and can evolve into IBD. This subclinical gut inflammation has been shown to be strongly associated with joint inflammation, providing a clue for a common pathophysiologic background. Despite extensive research progress in the field over the past few years, many questions remain unanswered. In this paper, we focus on the clinical, genetic, and pathophysiologic overlap of SpA and IBD. Furthermore, we discuss some of the targets that may i...
Precocious puberty is a significant child health problem, especially in girls, because 95% of cases are idiopathic. Our earlier studies demonstrated that low-dose levels of manganese (Mn) caused precocious puberty via stimulating the secretion of luteinizing hormone-releasing hormone (LHRH). Because glial-neuronal communications are important for the activation of LHRH secretion at puberty, we investigated the effects of prepubertal Mn exposure on specific glial-derived puberty-related genes known to affect neuronal LHRH release. Animals were supplemented with MnCl2 (10 mg/kg) or saline by gastric gavage from day 12 until day 22 or day 29, then decapitated, and brains removed. The site of LHRH release is the medial basal hypothalamus (MBH), and tissues from this area were analyzed by real-...
The synovial and bone uptake of tracer in the knees of patients with rheumatoid arthritis (RA) was quantified using {sup 99}Tc{sup m}-hexamethyl propylene amine oxime-labelled leucocytes and {sup 99}Tc{sup m}-methylene diphosphonate (MDP), respectively. Significant neutrophil migration and MDP uptake occurred in the knees of patients with RA irrespective of the disease duration. In all but one patient neutrophil migration was reduced after intra-articular steroid injection. The change in MDP uptake after steroid injection was variable. There was a significant correlation between the percentage reduction in neutrophil migration and pain score, while the latter correlated poorly with the change in MDP uptake. The quantification of the neutrophil component of the inflammatory process is a sensitive index for monitoring RA activity and response to pharmacological interventions, while quantitative bone scintigraphy should not be employed to monitor changes in joint ...
The synovial and bone uptake of tracer in the knees of patients with rheumatoid arthritis (RA) was quantified using "9"9Tc"m-hexamethyl propylene amine oxime-labelled leucocytes and "9"9Tc"m-methylene diphosphonate (MDP), respectively. Significant neutrophil migration and MDP uptake occurred in the knees of patients with RA irrespective of the disease duration. In all but one patient neutrophil migration was reduced after intra-articular steroid injection. The change in MDP uptake after steroid injection was variable. There was a significant correlation between the percentage reduction in neutrophil migration and pain score, while the latter correlated poorly with the change in MDP uptake. The quantification of the neutrophil component of the inflammatory process is a sensitive index for monitoring RA activity and response to pharmacological interventions, while quantitative bone scintigraphy should not be employed to monitor changes in joint inflammation in ...
The ability of "9"9"mTc-IgG scintigraphy to predict the development of rheumatoid arthritis (RA) in 47 patients with arthralgia was investigated. "9"9"mTc-IgG scintigraphy and the serum test for rheumatoid factor (RF), measured at the beginning of a year long study, were compared for their ability to predict RA. During the study 8 patients developed RA. The specificity and positive predictive values of RF in predicting RA were 79% and 50% respectively, and for "9"9"mTc-IgG scintigraphy 97% and 88%. The sensitivity and negative predictive values of RF were 100% and of "9"9"mTc-IgG-scintigraphy 88% and 97%, respectively. In conclusion, "9"9"mTc-IgG scintigraphy has additional value to RF with respect to the prediction of the development of RA in patients with arthralgia. 27 refs.
The aim of this study was to evaluate typical magnetic resonance imaging (MRI) findings in early rheumatic diseases manifesting at the soft tissues of the hand using a retrospective analysis. A total of 186 MRI examinations of patients with clinical suspicion of a rheumatic disease were evaluated in a consensus reading by two experienced radiologists. All imaging patterns were assessed with respect to their type and localization. Under blinded and non-blinded conditions diagnoses were correlated with final clinical diagnosis. The most frequent diagnoses were rheumatoid arthritis (RA, 45.7%) and psoriatic arthritis (PsA, 15.6%). The mean correlation between clinical and MRI diagnosis (r) was 0.75 in blinded and 0.853 in non-blinded reading (p <0.001). The following extra-articular imaging patterns were found: synovitis (59.1%), tendovaginitis (91.4%), dactylitis (14.5%), and bone marrow edema (18.3%). Only dactylitis was specific for a ...
Roentgenological analysis of the anterior chest wall was performed in twenty six patients with sternocostoclavicular hyperostosis. Initial hyperostotic change was seen at the first costosternal junction with ventral protrusion. Hyperostosis gradually developed around the first ribs, and irregular hyperostotic changes were also seen along the costoclavicular ligaments. Even in the final stage, however, sternoclavicular joint spaces were well preserved. These findings suggest that sternocostoclavicular hyperostosis is a disorder initiated around the costal cartilage including the periosteum and perichondrium, and that arthritis is not a condition stemming from that disorder.
As the U.S. Department of Energy's (DOE's) Solar Energy Technologies Program initiates new cost-shared solar energy R&D under the Solar America Initiative (SAI), it is useful to analyze the experience gained from cost-shared R&D projects that have been funded through the program to date. This report summarizes lessons learned from two DOE-sponsored photovoltaic (PV) projects: the Photovoltaic Manufacturing Technology/PV Manufacturing R&D (PVMaT/PVMR&D) project and the Thin-Film PV Partnership project. During the past 10-15 years, these two projects have invested roughly $330 million of government resources in cost-shared R&D and leveraged another $190 million in private-sector PV R&D investments. Following a description of key findings and brief descriptions of the PVMaT/PVMR&D and Thin-Film PV Partnership projects, this report presents lessons learned from the projects.
Individuals with male factor infertility resulting from idiopathic oligo-, astheno- or teratozoospermia are frequently offered IVF in an attempt to increase their chances of having a child. A concern remains whether these infertile males have an elevated risk of transmitting chromosomal abnormalities to their offspring. Sperm chromosomal complements from these men were assayed using the human sperm/hamster oocyte fusion system and fluorescence in situ hybridization (FISH) on sperm nuclei. For each of 5 infertile patients, 100 sperm karyotypes were analyzed and multicolour FISH analysis was performed on a minimum of 10,000 sperm nuclei for each chromosome-specific DNA probe for chromosomes 1 (pUC1.77), 12 (D12Z3), X (XC) and Y (DYZ3). As a group, the infertile patients showed increased frequencies of both numerical ({chi}{sup 2}=17.26, {proportional_to} <0.001) and total abnormalities ({chi}{sup 2}=7.78, {proportional_to} <0.01) relative to control donors when ...
Which imaging modalities are appropriate for the Differential diagnosis of Rheumatic diseases. MRI has far most the highest sensitivity and is unequaled in its brilliant presentation of Anatomy and Pathology. But it is sometimes forgotten, that this is at least in part the result of carefully selected sequences, dedicated to the expected result. In a method totally independent of any result, this should not be the case. In contrary this method should be highly standardised and regardless what will be the findings. This is true for Plain X-ray. It will be shown, that already the outer silhouette of the soft parts with different features of swelling, and differences in density and even more - defects or appositions of the bony silhouette in the majority of cases at least will allow to classify the patient for a group of diseases and in many cases will lead to a definite diagnosis. Differential diagnoses like Rheumatoid Arthritis versus Psoriatic ...
Exposure of teachers of physics to X-radiation emitted by instruments which are used for demonstrating rarefied gas discharges during physics lessons at secondary schools is discussed. The measurements performed provide an explicit evidence that an effective, annual exposure dose under the most unfavorable conditions does not exceed admissible levels according to Polish regulations pertaining to persons non-occupationally exposed to ionizing radiation. (author). 3 refs,1 fig.
The rod drop time event of the Daya Bay Nuclear Power Plant is caused by the malfunction of the guide tube developed by Framatome. Three temporary solutions were implemented successively and the long term solution was found in the process of searching for the root cause. The different solutions and the root cause are introduced. The safety analysis and license of the solutions are mainly discussed. Experiences and lessons are drawn by summarizing the important items related to nuclear safety.
This is an inquiry-based module created specifically for use with the PhET simulation Geometric Optics. It includes a lesson plan for teaching about convex lenses, step-by-step student directions, and a set of Power Point "clicker" questions for use as warm-up questions or informal assessment. This resource is part of a larger collection of interactive Java simulations for students of physics, developed by the Physics Education Technology project at the University of Colorado.
Long-term heat acclimation (AC, 30d/34°C) is a phenotypic adaptation leading to increased thermotolerance during heat stress (HS, 2 h 41°C). AC also renders protection against...Full Text Available
In November 1995, the Australian and New Zealand Environment and Conservation Council (ANZECC, the Council of State and National Environment Ministers) adopted a National Management Plan for PCBs. This was a significant milestone in the very long saga of Australian efforts to develop public policy and management structures for dealing with persistent organochlorine wastes. The author was part of a four-person consultation panel that carried out a public involvement program to assist and inform the process of developing the National Management Plan. The program involved, among other things, visiting every state and territory of Australia at least twice. This paper describes the development and delivery of the public involvement program, including ongoing interactions with Governments. The latter is often a complex (and many would say an unduly complex) matter in the federal system, where primary responsibility for waste management resides in the individual state/territory jurisdictions. ...
In this lesson you will learn about density and why some things float and others sink. Imagine you and a friend are on a camping trip. As you walk along a stream, your friend notices some shiny gold rocks. You pick them up wondering if they are real gold nuggets. Your friend remembers there is a mineral that looks like gold, "fools gold", or pyrite. The density of ...
This report presents the methodologies and results of the field/laboratory experiments and mathematical modeling defined for the phase III of the project. Results from test cases 2-6 are given in separate chapters of the report (which have been indexed separately), and the last chapter discusses the lessons learned from the three phases of the DECOVALEX project.
The aim of this review is to evaluate the role of inflammatory spine disease in patients with chronic back pain. The contribution of imaging modalities for the diagnostic evaluation of back pain is discussed. A systematic literature search based on the classification of seronegative spondyloarthropathies and rheumatoid arthritis was performed. The results of this search and the experiences in a large collective of rheumatological patients are analyzed. The prevalence of rheumatoid arthritis (1-2%) is comparable to that of spondyloarthropathies (1.9%). The etiology of these entities is not fully elucidated. Magnetic resonance imaging is increasingly used for early detection and surveillance of therapy with TNF-{alpha} antagonists. Bone marrow edema, which is only detectable with MRI, represents an early sign of inflammation. Therapy with TNF-{alpha} antagonists is based on clinical and laboratory criteria, and signs of inflammation in MRI. MRI ...
Abstract Tumor necrosis factor (TNF)- is a pro-inflammatory cytokine associated with psoriasis pathogenesis. Anti-TNF- therapies are effective in psoriasis. A significant weight gain has been reported in patients treated with anti-TNF- agents. The aim of the present study was to evaluate the body composition changes in psoriatic patients receiving anti-TNF- therapies according with disease phenotype. Forty patients affected with psoriasis were followed up for 24 weeks and divided into two groups: psoriasis vulgaris (PsO) and psoriatic arthritis (PsA). Anthropometric, blood biochemical, body composition parameters, resting metabolic rate, and disease activity indexes were measured at baseline and at week 24. After 24 weeks of anti-TNF- administration, the disease activity indexes and concen...
Abstract Recently, a study of patients with rheumatoid arthritis who developed herpes zoster while taking a tumor necrosis factor (TNF)- inhibitor reported a decreased incidence of postherpetic neuralgia. The objective of this study was to investigate whether patients on TNF- inhibitors who developed herpes zoster have a lower incidence of subsequent development of postherpetic neuralgia. A retrospective review of herpes zoster patients on TNF- inhibitors (infliximab, etanercept, or adalimumab) was conducted in 12 dermatology clinics. Medical records of such patients were reviewed thoroughly to confirm herpes zoster and TNF- inhibitors and any subsequent development of postherpetic neuralgia (pain score -3 out of 10 after 90 days of shingles onset) was noted. A total of 206 cases were revi...
Background. A 19-year-old girl was diagnosed with systemic lupus erythematosus, based on findings of arthritis, malar rash, positive antinuclear antibody test and high levels of antibodies to double-stranded DNA. Two months after diagnosis, the patient presented with a sudden drop in blood hemoglobin level. Several days later, she developed bloody sputum, rapidly progressive dyspnea and hypoxemia. High-resolution CT showed diffuse alveolar infiltrates in both lung fields.Investigations. Physical examination, complete blood count, erythrocyte sedimentation rate, urinalysis, 24-h urine protein excretion, fecal occult blood test, d-dimer test, acid hemolysis test, activated partial thromboplastin time and prothrombin time, direct and indirect Coombs tests, bone marrow smear, arterial blood ga...
Mycoplasma infections of small ruminants are known to exist in the Mediterranean region, Asia, Africa and cause significant economic impacts but little is known of the Mycoplasma spp. in sheep and goats in the Middle East. During the period of 2002-2003, 104 flocks of local sheep and goats (17 sheep, 27 goat and 60 mixed flocks) were surveyed for the occurrence of mycoplasma infections in Northern Jordan. The clinical signs seen in the studied flocks were, to varying degrees, mastitis in sheep and goats, arthritis, mainly in kids, and pneumonia in both sheep and goats of most age groups. Small ruminant farms were sampled and pooled milk samples and nasal swabs were collected for culture and isolation of mycoplasma. Mycoplasmas were isolated from 17 (26%) of the 62 milk samples and 12 (3.9%...
Abstract Objective. Anti-TNF-a antibodies has been suggested to modulate regulatory T cell (Treg) percentages in rheumatoid arthritis, but results from studies of Crohn's disease (CD) are conflicting. We investigated dynamic changes of circulating Tregs in CD during treatment with the anti-TNF-a-antibody adalimumab (Humira, Abbott Laboratories A/S, Emdrupvej 28C, DK-2100 Copenhagen). Material and methods. Blood samples from 26 CD patients were analysed using flow cytometry before and 1 and 26 weeks after initiation of adalimumab treatment to determine the percentage of Tregs among CD4++ T cells. Results. In spite of a significant decline in disease activity scores and biochemical markers of inflammation, during the first week of treatment, we did not observe early modulating effects of ada...
Abstract in english We hypothesized that chronic oral administration of the phosphodiesterase-5 inhibitor sildenafil could improve the exercise capacity and pulmonary hemodynamics in patients with pulmonary arterial hypertension (PAH) on the basis of previous short-term studies. We tested this hypothesis in 14 subjects with PAH, including seven patients with the idiopathic form and seven patients with atrial septal defects, but no other congenital heart abnormalities. Patients were subjected (more) to a 6-min walk test and dyspnea was graded according to the Borg scale. Pulmonary flow and pressures were measured by Doppler echocardiography. Patients were given sildenafil, 75 mg orally three times a day, and followed up for 1 year. Sildenafil therapy resulted in the following changes: increase in the 6-min walk distance from a median value of 387 m (range 0 to 484 m) to 462 m (range 408 to 588 m; P
Citrate is an important naturally occurring inhibitor of calcium stone formation in urine. Urinary citrate excretion was examined in 43 consecutive patients with recurrent idiopathic calcium nephrolithiasis and in 50 normal controls by a specific enzymatic technique. Hypocitraturia (<1.6 mmol/24h) was found in 14 (33%) stone formers compared to 6 (12%) normal controls (p = 0.03). Citrate excretion expressed as citrate-creatinine ratio in 24 hour urine samples was significantly lower in the stone formers than in the healthy controls (p = 0.03), and significantly lower in healthy men, compared to healthy females (p = 0.006). There was a great variability in urinary citrate levels in both groups, and a considerable overlap in the urinary citrate excretion between normal subjects and stone formers. Factors other than urinary citrate excretion must therefore be of importance in the pathophysiology of calcium stone formation. Citrate-calcium ratio in urine proved to ...
OBJECTIVE: To evaluate the interobserver agreement of ultrasonographic assessment of finger and toe joints in patients with rheumatoid arthritis (RA) by 2 investigators with different medical backgrounds. METHODS: Ultrasonography and clinical examination were performed on 150 small joints of 30 patients with active RA. A General Electric LOGIQ 500 ultrasound unit with a 7-13-MHz linear array transducer was used. In each patient, 5 preselected small joints (second and third metacarpophalangeal, second proximal interphalangeal, first and second metatarsophalangeal) were examined independently on the same day by 2 ultrasound investigators (an experienced musculoskeletal radiologist and a rheumatologist with limited ultrasound training). Joint effusion, synovial thickening, bone erosions, and power Doppler signal were evaluated in accordance with an introduced 4-grade semiquantitative scoring system, on which the investigators had reached consensus prior to the study. ...
What kind of lesson do we get from California situation? The first is that the sufficient investment to the operational regulation should be prepared as a system. It is necessary to introduce the systems related to capacity, such as the capacity market system that makes retail suppliers secure the fixed rate of their running peak-load as reserve capacity and other system that secure the 5-year supply capacity by a contract, in which suppliers can pay the penalty if they purchase more capacity than in the contract. The second is that the supplementary measures should be systematized for the supply system not to be in a panic in a case of the shortage situation of equipment. The exchange authority should control the regular inspection program on generators to reduce the market control of the supply companies. Through the supplementary system, the increase of electricity price must make the demand decrease. According to the current plan, it will be take a long time to ...
This report describes the conclusion of a two-part programme, begun in 1994 with the overall aim of assisting in the development of an acceptable public participation strategy for use in Sweden for the siting of contentious facilities, with particular reference to the ongoing siting programme for a deep repository for spent nuclear fuel. The first part of the work programme, a global review of siting practice, was reported as SSI Rapport 94-15, in November 1994. This recommended further detailed studies of at least two individual programmes, which have now been carried out in Canada and the United States, and are reported on here. They involved face to face meetings with many of the main stake holders in the two programmes and enabled valuable insight to be gained into the potential problems associated with increased public participation, as well as identifying good practice where it exists. The lessons learned have then been applied to the evolving repository ...
With its 527 217 m{sup 3} of low and medium activity wastes put in storage between 1969 and 1994, the C.S.M.( center of storage of Manche) is and remains to this day a necessary element to understand the problems posed by the eternal storage of nuclear materials and the limits of the notion of reversibility. There are therefore teachings to be drawn. We cannot repeat past mistakes in particular with high activity wastes which we wish to bury deep underground. This report is based on the analysis of the existing bibliography, of the internal A.N.D.R.A. documents which we released to the public, of the lessons drawn from our participation in the official concerting and work groups, and finally of the data obtained after inquiries were done in the region in the framework of R.I.V.I.E;R.E. (citizens network of radioecological surveillance, information and evaluation). In spite of all efforts produced, many questions remain unanswered regarding this site so it is ...
This study examines some radiation accidents occurred in the past. This information has been systematically assessed to get global lessons. The experience feedback shows that the most of accidents happened in certain conditions. These conditions can be distributed in four categories: 1- perception and vigilance in occupation: accidental exposure happened by lack of vigilance in details and lack of vigilance and perception; 2- procedures: accidental exposure happened following a lack of procedures or control that were not enough complete, not enough documented or not completely implemented; 3- training and understanding: accidental exposures happened because the personnel was not enough qualified and educated, did not get the general training nor the the necessary specialized training; 4- liabilities: accidental exposures happened following lacks and ambiguity in the definition of functions of the personnel and in the hierarchy liabilities. In these precise cases ...
Floating Production, Storage and Offloading (FPSO) systems have become a popular choice in recent years for marginal, fast-track or deepwater field developments world wide. However, the majority of these developments have incurred significant project delays and budget overruns as a result of commercial structure, project management and design/operating problems. The Health and Safety Executive (HSE) commissioned IGL Engineering Ltd to perform a study to highlight specific areas where safety concerns have arisen. The study also aims to identity the fundamental causes of problems and identify key lessons to be learned from such projects which can be used to the benefit of future developments. In summary, there are five fundamental areas where weaknesses can and have lead to the problems experienced in FPSO developments. The areas are all interrelated and many problems stem from deficiencies in more than one area. The areas are: commercial framework and project ...
The licensing status and procedures, regulatory framework, and current safety issues of CANDU type reactors, Wolsong units 2, 3 and 4 are examined. Licensing difficulties and lessons learned during the safety review of Wolsong 2, 3 and 4 and future requirements are also summarized. The review was conducted, not only to confirm the design adequacy with respect to the domestic atomic laws and regulatory requirements of the vendor country, Canada, but also to reflect into the design the lessons learned from the regulatory experiences of operating Wolsong I to enhance the safety as high as practically possible. Safety issues observed during the licensing review, such as containment integrity, fuel channel integrity, etc., are summarized. Several efforts have been conducted to harmonize the Canadian regulations with the Korean ones by establishing domestic regulatory positions and guidelines. For example, the utility was requested to produce the ...
Fatigue damage occurs in general when a boiler tube is subject to repeat cyclic or fluctuating loading although the stress produced is below the material yield strength. The types of fatigue damage include, e.g., corrosion, thermal, mechanical, vibration, and creep fatigue. It is important to determine which form of fatigue is active, because measures to avoid repeat failures differ as the case arises. In this lesson, the focus is exclusively on corrosion fatigue. Corrosion fatigue occurs by the combined synergistic actions of cyclic loading and a corrosive environment. It is a discontinuous process with crack initiation and growth during transient periods. The excessive stresses may be caused during boiler operation by the restraint at tube attachments and by load changes (in particular during cold starts or forced cools) or during shutdown or restart of circulation boilers by thermal stratification of water along the tube length. Poor water chemistry and its ...
The Wind2H2 system is fully functional and continues to gather performance data. In this report, specifications of the Wind2H2 equipment (electrolyzers, compressor, hydrogen storage tanks, and the hydrogen fueled generator) are summarized. System operational experience and lessons learned are discussed. Valuable operational experience is shared through running, testing, daily operations, and troubleshooting the Wind2H2 system and equipment errors are being logged to help evaluate the reliability of the system.
Unmanned systems are often used to augment the ability of humans to perform challenging tasks. While the value of individual unmanned vehicles have been proven for a variety of tasks, it is less understood how multiple unmanned systems should be used together to accomplish larger missions such as site security. The purpose of this paper is to discuss efforts by researchers at the Idaho National Laboratory (INL) to explore the utility and practicality of operating multiple unmanned systems for a site security mission. This paper reviews the technology developed for a multi-agent mission and summarizes the lessons-learned from a technology demonstration.
As radiation detection in the interest of national security becomes increasingly commonplace, inevitable questions arise concerning the interpretation of data from handheld radioisotope identifiers (RIIDs). Field elements typically require fast answers to provide an effective defense and to minimize the impact on legitimate movement of people and goods. To support this need, on-call experts at Sandia, Los Alamos, and Lawrence Livermore national laboratories cooperate in resolving radiation alarms rapidly and accurately. We present an overview, describe the work in progress to improve capabilities, and report on some of the lessons learned.
Late 1994, the Geothermal Heat Pump Consortium (GHPC) was launched as a non-profit collaborative effort between the United States Department of Energy, US electric utilities and the GeoExchange (geothermal heat pump) industry to make ''geothermal heat pumps'' a significant component of the HVAC industry and avoid 1.5 million metric tons of carbon equivalent per year. The goal was to create a self-sustainable GeoExchange market. This report offers a summary of some of the lessons learned and an overview of some of the programs major accomplishments.
Foinaven and Schiehallion/Loyal are the first oilfields West of Shetland (WoS). They were developed using Floating Production, Storage and Offloading (FPSO) technology in water depths of between 350m and 550m and arguably the harshest environmental conditions yet experienced offshore. Traditional project time scales were halved by shortening and overlapping the reservoir and facilities developments. This paper describes some of the challenges faced by the geotechnical engineers working on these projects and summarises lessons learnt from site investigations and the design and installation of foundations. (author)
This construction curriculum guide on masonry for secondary students is one of six developed for inservice teachers at Marianas High School in Saipan. The guide provides the rationale, description, goals, and objectives of the program; the program of studies and performance objectives by levels; samples of lesson plans for effective delivery of instruction; and a listing of references. Concepts covered include orientation to masonry construction, safety, tools and equipment, cement, concrete, concrete block masonry, concrete forms, and concrete reinforcement. Appended materials include transparency copies, tests and answer keys, information sheets, and student activities. (CT)
The aim of this study was to evaluate typical magnetic resonance imaging (MRI) findings in early rheumatic diseases manifesting at the soft tissues of the hand using a retrospective analysis. A total of 186 MRI examinations of patients with clinical suspicion of a rheumatic disease were evaluated in a consensus reading by two experienced radiologists. All imaging patterns were assessed with respect to their type and localization. Under blinded and non-blinded conditions diagnoses were correlated with final clinical diagnosis. The most frequent diagnoses were rheumatoid arthritis (RA, 45.7%) and psoriatic arthritis (PsA, 15.6%). The mean correlation between clinical and MRI diagnosis (r) was 0.75 in blinded and 0.853 in non-blinded reading (p <0.001). The following extra-articular imaging patterns were found: synovitis (59.1%), tendovaginitis (91.4%), dactylitis (14.5%), and bone marrow edema (18.3%). Only dactylitis was specific for a ...
Dose measurements were performed in several body regions of patients suffering from inflammatory degenerative diseases (humeral epicondylitis, humeroscapular periarthritis, gonarthrosis, axillary hidradenitis, rheumatoid arthritis, coxarthrosis, parotitis). The problem of the radiation induction of neoplasms is predominant concerning somatic as well as genetic risk, discussed by example of the most frequently occurring organ cancer. Compared to the rate of breast cancer in the highly developed industrial states (5,000 to 6,000 cancers/100,000 women) the 'radiation induction' calculated according to a mathematical model of ICRP 26 (1.25 cases of death for breast cancers/100,000 women following for example irradiation of epicondylitis) is behind several powers of ten and not demonstrable. The genetic radiation exposure is also low. Derived from the measurements it is wrong to give up reliable and approved indications of radiotherapy of non-malignant diseases because ...
Radioactive particles as well as x irradiation from an external source has been used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. In order to clarify effects of ionizing irradiation on synovial cells, radioactive gold ("1"9"8Au) and yttrium ("9"0Y) were added to fibroblast cultures derived from human synovial membranes. Other cultures were irradiated by a Picker x-ray machine. Fibroblast growth and hyaluronic acid production were measured. Radioactive gold and yttrium particles induced a significant increase of hyaluronic acid synthesis rate (pg/cell/day) and inhibited fibroblast growth. Fibroblasts continued to overproduce hyaluronic acid and to show growth inhibition 3 weeks after irradiation with radioactive gold. Hydrocortisone inhibited hyaluronic acid overproduction induced by radioactive gold. Overproduction of hyaluronic acid induced by the x-ray machine was inhibited by hydrocortisone, actinomycin-D, and ...
To assess the utility of magnetic resonance (MR) imaging in the study of pediatric patients with clinical suspicion of pituitary disease. We studied 18 patients aged 7 to 18 years.Fifteen had hormonal disturbances, two presented amenorrhea and 1 complained of headache, fever and symptoms of polyuria and polydipsia. All the patients were examined using a Siemens SP 42 1-Tesla MRI scanner. Sagittal and coronal T1-weighted spin-echo images were obtained; in addition T2-weighted spin-echo or fast spin-echo imaging was performed in ten cases and intravenous gadolinium was administered in nine. We found 9 patients with hypothalamic-pituitary dysgenesis, 2 with germinoma, 2 cases of pituitary hemosiderosis in patients with thalassemia, 2 cases of microadenoma, one abscess, one case of idiopathic central diabetes insipidus and one of Langerhans cell histiocytosis. MR enabled us to assess pituitary structural alterations in children with hypothalamic-pituitary hormone ...
Full text: Disorders of brain development and phakomatosis are resulting from disturbed embryonic-foetal development One third of all major embryological anomalies involve CNS, and over 2000 different anomalies have been described. Anomalies of the brain often cause foetal and neonatal death, and mental and physical retardation in pediatric group. The majority of disorders of brain development and phakomatosis are idiopathic, and most of them are not hereditary or familial. Ultrasonography plays the important role in screening foetal and neonatal brain, but after closure of fontanels it is difficult to find the acoustic window. CT has limited contrast resolution, and disadvantage exposing infant to ionizing radiation. It is helpful to demonstrate the presence of calcifications. MR imaging has proved to be a diagnostic tool of major importance in children with disorders of brain development and phakomatosis. The excellent grey/white matter differentiation and ...
Bone formation and resorption have been measured in patients with idiopathic osteoporosis by histomorphometry of 7.5-mm trephine biopsies and in the whole body by 85Sr radiotracer methodology and calcium balances. The studies were synchronized and most were preceded by double in vivo tetracycline labeling. Correlations between histological and kinetic bone formation indices were better when better when based on the extent of double tetracycline labels than on measurements of osteoid by visible light microscopy. Correction of the kinetic data for long-term exchange, using 5 months' serial whole body counting of retained 85Sr, improved the fit of the kinetic to the histological data. A statistical analysis of the measurement uncertainties showed that the residual scatter in the best correlations (between exchange-corrected bone formation rates and double-labeled osteoid surface indices) could be attributed to measurement imprecision alone. The ...
Lack of access to basic education leads to diminished individual and national capabilities, therewith furthering cycles of poverty. An equitable education system meeting basic learning needs represents not only a human right, but also a means for reducing poverty, promoting productivity, and sustaining development. The Government of China--the most populous developing nation, the majority of whose citizens live in rural areas--has been committed to universalizing nine-year compulsory education among school-aged children and eliminating illiteracy among youths and adults aged 15-45. This study examines lessons learned from China's efforts in these areas. It also reports on current challenges and trends in a new national initiative for achieving high-quality universal basic education by the year 2007.
The United State Domestic Research Reactor Infrastructure Program at the Idaho National Laboratory manages and provides project management, technical, quality engineering, quality inspection and nuclear material support for the United States Department of Energy sponsored University Reactor Fuels Program. This program provides fresh, unirradiated nuclear fuel to Domestic University Research Reactor Facilities and is responsible for the return of the DOE-owned, irradiated nuclear fuel over the life of the program. This presentation will introduce the program management team, the universities supported by the program, the status of the program and focus on the return process of irradiated nuclear fuel for long term storage at DOE managed receipt facilities. It will include lessons learned from research reactor facilities that have successfully shipped spent fuel elements to DOE receipt facilities.
The Education for All-Fast Track Initiative (FTI) grew out of the "New Focus on Education for All" communique of the G-8 when Canada hosted the summit in 2002 at Kananaskis. As Canada prepares again to host the G-8, and Korea assumes leadership of the newly-empowered G-20, it is a valuable moment to revisit and re-think the current global education architecture. By adopting some of the recommendations from the recent independent evaluation of the FTI and borrowing some lessons from global partnerships in other sectors, the FTI could set a new course toward the achievement of universal basic education. The FTI should broaden and strengthen the role of diverse stakeholders from developing countries and civil society in its governance structure in order to fully harness the energies of these stakeholders in resource mobilization and effective implementation. (Contains 9 endnotes.)
Full text: The nuclear renaissance, anticipated by AREVA in the beginning of the century is now happening in several countries around the world. The fundamentals being the increasing demand of energy, the volatility of fossil fuel prices, the awareness of climate change threat connected with the extensive use of fossil fuels. The EPRTM reactor present significant improvements compared to previous generation reactors enabling to reach an outstanding safety level (redundancy of safety systems, airplane crash resistance), to improve the economics (extended plant lifetime, flexibility and availability during operation and, increased efficiency and fuel utilization) while limiting the impact on workers and the environment. Several countries have been implementing the transition to third generation reactors. The presentation will analyze different examples in order to draw the lessons learned from this first wave and to set-up the criteria for a successful transition ...
The information gathered as operating manager when implementing the first photovoltaic rural electrification and technology transfer program carried out to date in the world in French Polynesia from 1978 to 1990 are detailed. The technical developments of equipment and the work in progress at the GENEC Cadarache within French, European or IEA programs in order to improve some components or appliances and make up for certain deficiencies are presented. This involves accelerated aging tests, Standardization work, development of high efficiency equipment. Non technical barriers are often emphasized. Technical barriers also exists. Considerable work in many domains of small PV systems remains to be done so as to combine all the conditions required to implement successful large programs in developed as well as in developing countries.
This article identifies the imperatives behind the need to move away from teaching based on the transmission of a lot of facts to teaching that enables students to become lifelong learners. It reminds us that the over-riding goal is an education process that maximizes the ability of teachers to teach well and of students to learn effectively. It argues that the necessary reform process can only be successful if the three components of an education programme--the curriculum, teaching strategies and assessment--are reformed simultaneously to ensure that each is designed to produce more effective teaching and learning. It points to the literature that tells us what we know about factors affecting student behaviour and, in particular, notes the crucial factor of student perception of the requirement of the assessment regime. It recommends that Biggs' model of constructive alignment is used as the organizing principle of continuing reform.
Performance of electric vehicles (EVs) is being studied in an ongoing Site Operator Program, as part of the Electric and Hybrid Vehicle Program supported by the U.S. Department of Energy (DOE). More than 200 EVs are being operated by Site Operators in various geographical and climatic regions of the United States. Cold-weather operation of EVs is of particular interest. As expected, low temperatures affect a battery`s ability to accept a charge, which decreases EV range and increases operating costs. Battery types other than lead-acid are being evaluated such as nickel-iron, gelled electrolyte lead-acid, nickel-cadmium, and sodium-sulfur. Also, improved methods of collecting EV performance data are being implemented, thermal management systems are being tested, and a prototype ultracapacitor is being tested as a possible alternative to conventional batteries.
Electricity generation from wind turbines is now cost competitive for grid and off-grid applications in many developing regions, and close to competitive in others. Wind resources could generate thousands of megawatts of badly-needed power in Asia, North Africa, and Latin America. Barriers to penetrating power generation markets remain, however, including unequal access to investment capital, energy price and other market distortions, and often weak institutions for commercializing new technologies. Recognizing the potential economic and environmental benefits of wind power, bilateral and multilateral assistance organizations have for several years offered financial and technical assistance to promote its diffusion. Based on this experience and assistance for other renewable electric technologies, lessons and recommendations can be drawn regarding how assistance could more effectively overcome persistent market and policy barriers, especially in light of the ...
The Electric Power Research Institute has published a report for planners, designers, owners, and operators of hydroelectric pumped-storage plants that records the operation and maintenance knowledge of 35 domestic and foreign pumped-storage projects. The report provides a comprehensive record of practices that have reduced forced outages and shortened scheduled repairs. As time passes and experienced staff retire at pumped-storage plants, many O M lessons are lost. To remedy that situation, EPRI commissioned Morrison-Knudsen Engineers Inc. to prepare a special report. The 348-page publication records the accumulated civil, geotechnical, mechanical, and electrical O M knowledge and experiences of pumped-storage plant staff. It also includes recommendations to planners and designers of future pumped-storage plants and concludes with descriptions of O M experiences reported by plant operators and utility representatives.
Moodle is an extended learning management system for developing learning units, including mathematically-based subjects. A wide variety of material can be developed in Moodle which contains facilities for forums, questionnaires, lessons, tasks, wikis, glossaries and chats. Therefore, the Moodle platform provides a meeting point for those working in a mathematics course. Mathematics requires special materials and activities: The material must include mathematical objects and the activities included in the virtual course must be able to do mathematical computations. WIRIS is a powerful software for educational environments. It has libraries for calculus, algebra, geometry and much more. In this article, examples showing the use of WIRIS in numerical methods and examples of using a new tool, ...
Abstract: The current financial crisis has now led most major central banks to rely on quantitative easing. The unique Japanese experience of quantitative easing is the only experience which enables us to judge this therapy's effectiveness and the timing of the exit strategy. In this paper, we provide a new empirical framework to examine the effectiveness of Japanese monetary policy during the ''lost'' decade and quantify the effect of quantitative easing on Japan's activity and prices. We combine advantages of Markov-switching VAR methodology with those of factor analysis to establish two major findings. First, we show that the decisive change in regime occurred in two steps: it crept out from late 1995 and established itself durably in February 1999. Second, we show for the first time th...
Dr. Rudolf Schulten of West Germany and expert witnesses from national laboratories, utilities, and the nuclear industry testified on reactor safety issues as they relate to the Chernobyl accident and public concern that modern technology has not paid enough attention to public safety. Each of the witnesses contributed safety-related information based on what has been learned from the Soviet incident. Particular focus went to similarities and differences between the Chernobyl and US reactors in safety design and engineering and to the environmental effects of the accident. The N reactor near Richland and a commercial reactor at Fort St. Vrain, Colorado are the only two operating graphite reactors, but neither is a boiling water reactor.
Dr. Rudolf Schulten of West Germany and expert witnesses from national laboratories, utilities, and the nuclear industry testified on reactor safety issues as they relate to the Chernobyl accident and public concern that modern technology has not paid enough attention to public safety. Each of the witnesses contributed safety-related information based on what has been learned from the Soviet incident. Particular focus went to similarities and differences between the Chernobyl and US reactors in safety design and engineering and to the environmental effects of the accident. The N reactor near Richland and a commercial reactor at Fort St. Vrain, Colorado are the only two operating graphite reactors, but neither is a boiling water reactor.
Although managing fisheries is complex, policymakers must make decisions daily that affect the future of aquatic resources. To make these decisions, they often combine a mental model with lessons learned from formal models such as computer models. While such computer models are frequently interpreted as predictors of the future, they are often more valuable when used as tools for learning about fisheries and options for management. This approach, looking at computer simulations as learning laboratories, is what this study is all about since its objective is to investigate by means of a microworld if policymakers in Belgian fisheries have the policy instruments at hand to align the real fisheries world with their often completely different desired fisheries worlds. This study illustrates ba...
This issue of Carbon Market Perspectives on 'Pathways for implementing REDD+: Experience from carbon markets and communities' discusses the role of carbon markets in scaling up investments for REDD+ in developing countries. Nine articles authored by experienced negotiators on REDD+, carbon market actors, project developers and other leading experts share experiences and make suggestions on the key elements of a future international REDD+ regime: Architecture and underlying principles, measuring, reporting and verification (MRV), private-sector involvement, the rights of indigenous people and local communities, biodiversity conservation and environmental integrity. The articles are grouped under three main topics: the lessons of existing REDD+ projects; the future REDD+ regime and the role of carbon markets; and experiences and ideas about the involvement of indigenous people and local communities. (LN)
Implementing any new business software can be an intimidating prospect and this paper is intended to offer some insight in to how to approach this challenge with some fundamental rules for success. Los Alamos National Laboratory (LANL) had undergone an original ERP implementation of HRMS, Oracle Advanced Benefits, Worker Self Service, Manager Self Service, Project Accounting, Financials and PO, and recently completed a project to implement Oracle Payroll, Time and Labor and Accrual Plans. This paper will describe some of the important lessons that can be applied to any implementation as a whole, and then specifically how this knowledge was applied to the design and deployment of Oracle Accrual Plans for LANL. Finally, detail on the functionality available in Oracle Accrual Plans will be described, as well as the detailed setups.that were utilized at LANL.
The alliance of J. Robert Oppenheimer, scientist, and Leslie R. Groves, military leader, is often interpreted as the classic example of the clash between the academic mind and the military style. Evidence suggests, instead, that it was a collaboration that led to the dawn of the nuclear age. Instead of a clash, it was collaboration and an implosion of the diverse talents needed for the success of this project. Discussion of these flawed and fascinating individuals still ignites controversy today. This presentation will explore the backgrounds and personalities of these two men and their work together to accomplish their mission. Was the aftermath inevitable, given a relationship based on respect, but perhaps not trust? The genesis of the modern military-industrial complex rested on the genius of these two men, though they personify two distinct American sub-cultures. What lessons can be drawn from their wartime and post-war relationship? What analogies can be drawn ...
Recent improvements in cell purification and transplantation techniques have contributed to the identification of cell populations known as tumor-initiating cells (TIC). This discovery has led to the -cancer stem cell hierarchy- concept, which holds that tumors are organized as a hierarchy of malignant tissues sustained by such TIC. However, this concept remains controversial. In this review, we examine recent advances in cancer stem cell research that have been generated from studies of Philadelphia (Ph) chromosome-positive leukemia. The abnormal Ph chromosome, which arises from a translocation creating the BCR-ABL1 fusion gene, is most commonly associated with chronic myelogenous leukemia (CML) and precursor B cell acute lymphoblastic leukemia (B-ALL). Examination of the pathophysiology ...
Shell UK Exploration and Production, operating in the North Sea on behalf of Shell UK and Esso UK is presented developing the Teal and Guillemot fields in the Central North Sea (CNS). As part of this development it contracted with Single Buoy Moorings Inc., (SBM) for the design, supply and installation of a newbuilt floating Production Storage and Offloading (FPSO) vessel. The work is executed in close cooperation between Shell Expro (Client) and SBM (Contractor) and its main sub contractors. The system is due to be installed during the third quarter of 1996. After a short description of the field development and the FPSO vessel this paper outlines the contractual arrangements and the organization set-up to perform the work. A summary of the lessons learned (by SBM) is given. The opinions expressed in this paper are entirely that of the author and may not necessarily reflect the opinion of other parties involved in the CNS FPU project.
Purpose - The purpose of this paper is to show that the need to communicate the value of libraries is growing, and especially now during the global financial crisis. As a response library valuation research is expanding and there is now a need for a status report. Design/methodology/approach - The library valuation field is developing towards generating a critical mass of empirical studies. The focus of the meta-analytical review is on the subgroup that reports a return on investment (ROI) or a cost-benefit ratio. Meta-analysis is a quantitative analysis of findings of previous studies, conducted to infer general findings and lessons from prior empirical research. The dataset is 38 library valuation studies reporting a return on investment figure or cost-benefit ratio. Findings - Of the 38...
Industrial radiography accounts for approximately half of all the reported accidents for the nuclear related industry, in both developed and developing countries. This Safety Report is the result of a review made of a large selection of accidents in industrial radiography reported by regulatory authorities, professional associations and scientific journals. A small, representative selection of 43 accident descriptions has been used to illustrate the primary causes of radiography accidents, and a set of measures provided to prevent the recurrence of such accidents or to mitigate the consequences of those that do occur. These accident descriptions were categorized by primary causes as follows: inadequate regulatory control; failure to follow operational procedures; inadequate training; inadequate maintenance; human error; equipment malfunction or defect; design flaws; and wilful violation. The information in this Safety report is intended for use by those regulatory authorities, ...
The diagnostic designs for the Laser Megajoule (LMJ) will require components to operate in environments far more severe than those encountered in present facilities. This harsh environment will be induced by fluxes of neutrons, gamma rays, energetic ions, electromagnetic radiations, and, in some cases, debris and shrapnel, at levels several orders of magnitude higher than those experienced today on existing facilities. The lessons learned about the vulnerabilities of present diagnostic parts fielded mainly on OMEGA for many years, have been very useful guide for the design of future LMJ diagnostics. The present and future LMJ diagnostic designs including this vulnerability approach and their main mitigation techniques will be presented together with the main characteristics of the LMJ facility that provide for diagnostic protection.
In 1992, the Society of Automotive Engineers (SAE) established a task force to develop a procedure for measuring electric energy consumption, all-electric range, fuel economy, and exhaust emissions for hybrid vehicles; the procedure will be submitted to regulatory agencies as representing the automotive industry`s recommendations. The draft procedure is currently being tested on hybrid vehicles. The University of Maryland`s parallel hybrid was tested in September 1994, and the University of California-Davis` parallel hybrid and the University of Illinois` series hybrid will be tested in November 1994 and January 1995, respectively. The procedure is being modified to incorporate any lessons learned, and the task force hopes to recommend the final procedure to the SAE by mid 1995.
Purpose Laparoscopic orchiopexy is a safe operation. However, the bladder can be injured during creation of the transperitoneal tunnel for the cryptorchid testis. We reviewed our experience with this complication. Materials and Methods We searched the operative notes of patients who had undergone laparoscopic orchiopexy between August 15, 2002 and October 1, 2008, and identified bladder injuries and their treatment. Results A total of 93 patients underwent laparoscopic orchiopexies for 101 undescended testes during the study interval, with 3 procedures resulting in bladder injuries. The 3 operations varied with regard to whether the injury was recognized intraoperatively or postoperatively, and repaired in an open or laparoscopic fashion. Conclusions Bladder injury during laparoscopic orch...
The article maps the risk management failures within Anglo Irish Bank, showing that, when banks are systemic in nature, poor internal corporate governance within a Minsky credit cycle can lead to destabilising macroeconomic conditions, which may prolong the effects of a credit-induced downturn. The article highlights a failure of management at Anglo Irish Bank to establish and measure firm-level risks and develop appropriate internal controls to support a culture of prudent credit management. We propose the adoption of a novel supervisory architecture based on the meta-risk regulatory philosophy, which is designed to strengthen risk management practices at banks.
The Teachers` Academy for Mathematics and Science in Chicago (TAMS) is a freestanding institution founded in 1989 by scientists and a variety of other stakeholders, to advance the systemic reform of mathematics and science education in Chicago`s public schools. It focuses on the ``re-tooling`` of its elementary level teachers. The TAMS program, which has been funded in part by the DOE, contributes to strategic goals two through five of the Office of University and Science Education (OUSE). This evaluation of TAMS by the National Center for Improving Science Education is primarily a qualitative study that summarizes the history and current status of the organization and its programs. Data was obtained through extensive interviews, observations, and document review, using a framework of templates to guide data collection and analyses. The findings are organized around a series of lessons learned from the first three years of TAMS and conclusions about its current ...
The most significant lessons provided by these developments at SASOL are the importance of long-range planning and the need for establishing a commercialized technology base in synfuels. These are necessary to reduce our dependence on foreign energy sources and can be accomplished with suitable cooperation between government and private industry and between agencies within the government. The Fischer-Tropsch process is not the only method for producing gasoline from coal, but so far it is the only one commercially proven. Another process, which produces gasoline from methanol, has been considered for commercialization. The government of New Zealand decided in December 1979 to build a commercial-size plant using its abundant natural gas as the feedstock in a natural gas to methanol to gasoline process. Because methanol can also be produced from gasified coal, this process may be an attractive option for the production of gasoline from coal in the United States. ...
The most significant lessons provided by these developments at SASOL are the importance of long-range planning and the need for establishing a commercialized technology base in synfuels. These are necessary to reduce our dependence on foreign energy sources and can be accomplished with suitable cooperation between government and private industry and between agencies within the government. The Fischer-Tropsch process is not the only method for producing gasoline from coal, but so far it is the only one commercially proven. Another process, which produces gasoline from methanol, has been considered for commercialization. The government of New Zealand decided in December 1979 to build a commercial-size plant using its abundant natural gas as the feedstock in a natural gas to methanol to gasoline process. Because methanol can also be produced from gasified coal, this process may be an attractive option for the production of gasoline from coal in the United States. ...
Groups are assigned or formed to perform tasks that one person cannot accomplish alone. This lesson describes the classification of work groups, group unity, leadership, motivation, recognition, conflict resolution, and remediation associated with managing groups and their activities. Advantages associated with group process include 1) the generation of better ideas, 2) ability to assume greater risks; make fewer errors; 3) the capacity for greater knowledge and 4) information, and for some problems, production of better decisions. Groups may be formal or informal. Formal groups may be organic, task-directed, or committees. Informal groups arise when it becomes obvious that a group will work better or may be formed by a discipline within the organization or through friendships. The size of the group its status within the organization, the goals established, and the dependence of the members on the group all may affect the cohesiveness of the group. Leadership of ...
Devolution, as other types of decentralization (e.g. deconcentration, delegation, privatization), profoundly changes governance relations in the health system. Devolution is meant to affect performance of the health system by transferring responsibilities and authority to locally elected governments. The key question of this article is: what does devolution mean for human resources for health in Mali?This article assesses the key advantages and dilemmas associated with devolution such as responsiveness to local needs, downward accountability and health worker retention. Challenges of politics and capacities are also addressed in relation to human resources for health at the local level. Examples are derived from experiences in Mali with a capacity development programme and from case studies of other countries. It is not research findings that are presented, but highlights of key issues at stake aimed at inspiring the debate in Mali and elsewhere.A first lesson from ...
Purpose: The nint version of the licensing regulation for medical doctors (Approbation Regulation (AR)) sets a benchmark in terms of practical experience, interdigitation of preclinical and clinical studies, interdisciplinary approach, economic efficiency, independence of students, added new teaching and learning modalities, and ongoing evaluation of the progress of the medical students. It is the aim to implement these major points of the AR in a model course for diagnostic radiology and radiation protection within the scope of the Virtual University of Bavaria and test them in practice. Materials and Methods: In cooperation with residents and board certified radiologists, students developed the virtual course 'Web-Based Training (WBT) Radiology' in diagnostic radiology and radiation protection for students in the first clinical semester. A representative target group taken from the student body was asked about the options to get access to the World Wide Web ...
Objective: To assess dynamic MRI with Gd-DTPA enhancement for evaluating inflammatory changes in the subacromial bursa. Design and patients: We detected the signal intensity changes in dynamic MRI of the subacromial bursa, and confirmed these macroscopically by arthroscopy and histologically. The signal intensity was measured using built-in software, and the enhancement ratio (E ratio) was calculated from dynamic MR images. In addition, as a parameter of the rate of the increase in the signal intensity from 0 to 80 s, the mean increase per second in the E ratio was obtained as the coefficient of enhancement (CE). The correlation was studied of the E ratio and CE with the arthroscopic findings (redness, villous formation, thickening and adhesion), and of the E ratio and CE with the histological findings (capillary proliferation, papillary hyperplasia, fibrosis and inflammatory cell infiltration) of the subacromial bursa. Of patients with shoulder pain, this study included those with ...
In the next decade Type Ia supernovae (SNe Ia) will be used to test theories predicting changes in the Dark Energy equation of state with time. Ultimately this requires a dedicated space mission like JDEM. SNe Ia are mature cosmological probes --- their limitations are well characterized, and a path to improvement is clear. Dominant systematic errors include photometric calibration, selection effects, reddening, and population-dependent differences. Building on past lessons, well-controlled new surveys are poised to make strides in these areas: the Palomar Transient Factory, Skymapper, La Silla QUEST, Pan-STARRS, the Dark Energy Survey, LSST, and JDEM. They will obviate historical calibrations and selection biases, and allow comparisons via large subsamples. Some systematics follow from our ignorance of SN Ia progenitors, which there is hope of determining with SN Ia rate studies from 0
In Slovenia two superb vegetable oils with high added nutritional value are produced: "Ekstra devisko oljcno olje Slovenske Istre (extra virgin olive oil from Slovene Istra)" and "Stajersko prekmursko bucno olje (pumpkin seed oil from Slovenia)". Their quality and genuineness must be monitored as adulteration can easily be undertaken. Olive oil genuineness determination experiences can show how analyses following an experience data-driven decision tree gathering several chemical determinations (fatty acids, (E)-isomers of fatty acids, sterol and tocopherol determinations) may be helpful in assessing the pumpkin seed oil from Slovenia genuineness. In the present work a set of HPLC triacylglycerol determinations was performed, based on the nine main triacylglycerols (LLLn, LLL, PLL, LOO, PLO, OOO, POO, SPL, and SLS) on a limited number of different pumpkin seed oils from northeastern Slovenia. The performed determinations showed that stereospecific analyses of triacylglycerols together ...
Commissioning of a Pressurized heavy water reactor (PHWR) plant of NPCIL involves three phases viz phase-A which consist of pre-criticality activities such as hydro test, air hold test, no load test of motors etc., phase-B consist of criticality and post criticality physics experiments. The phase-C, which is considered the major phase, consist of initial power raise to about 10 % , TG rolling, synchronization, going to significant power in steps and performance tests such as load rejection tests from various power levels. In order to have smooth commissioning for the Phase-C, an integrated team consisting of engineers from various design and analysis groups of NPCIL headquarters was formed to participate along with site O and M engineers, closely observe and coordinate phase-C commissioning activities. During this commissioning some major events and observations took place. An attempt is made to bring out the salient observations of Tarapur-4 Phase-C commissioning. This covers various ...
This paper addresses the major issues beginning teachers face in their first postings to rural areas in Australia. The issues go beyond pedagogy. Beginning teachers need to understand social factors affecting rural communities so they can link lessons to the realities experienced by students. Geographic isolation affects the provision of education in terms of time taken to travel, cost, terrain, and technology. Rural communities have groups that are socially isolated from each other and from the staff in schools. In order to teach effectively, teachers need to be aware of the social context of the community in which they live and work. Teachers in rural areas suffer from professional isolation and often confront teaching situations for which they have had little formal preparation. Communities in remote places often move quickly to adopt technological means to overcome their isolation. Teachers in rural areas need to identify and promote the media skills of ...
In the Department of Radiology of Catholic University S. Cuore in Rome, a review was made of 342 CT examinations with a view towards optimizing the therapeutic planning in patients affected by bone metastases. All patients were submitted to radiological positioning and then to CT evaluation in order to assess the volume to be treated. In 224 cases it was not necessary to perform wide CT examination (3-5 standard tomograms being enough, 2 of which at the superior and inferior margins of the planned field). In the second group of 118 patients it was necessary to perform CT (serial axial scans) - increasing by 1-1.5 cm - up to the superior and inferior margins of the lesion. The existence of 2 types of lesions was confirmed: those involving mainly bony structures and those infiltrating the soft tissues. CT evaluation allowed the definition of the target volume to the real extension of the lesion in 14% of the whole of cases, while in the group of 118 cases studied more thoroughly, the ...
The nature of the 5f electronic structure of plutonium (Pu) remains unclear. [1] Despite many recent attempts to resolve the issue, a plethora of important unanswered questions remain. While many theoretical approaches to the problem have been promulgated, the real source of the difficulty is the absence of sufficient experimental benchmarking. This paucity of impact on the part of experimental results is driven in part by the difficulties of working with Pu: it is highly radioactive, biologically toxic, chemically reactive and restricted in its distribution and permitted access to user facilities. The results of these liabilities include the following: (1) it is very difficult, if not impossible, to get large single crystals of single phase samples and; (2) many state of the art experiments can not be done because general user facilities are not available for use with Pu samples. Additionally, there is the apparently bizarre nature of Pu, which seems to defeat the efforts to analyze ...
This report contains the operation procedures in extreme situations and lessons learned from blackouts, based on a mandate given by the Operations Committee. Nordic TSOs have had common rules and principles for system operation i.e. System Operation Agreement since the late 1990s. The rules have been revised according to the system security and market changes and needs. The collaboration between system operators is regular and fruitful. The knowledge and capability to manage extreme situations of the Nordic power system has continuously increased and the recent blackouts did not show major deficiencies in operation practices. Regardless of the existing good collaboration it is important to continue development in the future in order to ensure high system security. Important development areas are security of reserve supervision and coordination of calculation procedures for transmission limits, enhancement of data exchange routines between control centres in order ...
Interest in renewable energy systems that employ regenerative components to enable intermittent energy sources to service time varying loads is growing. The overall performance of these systems is intimately linked to the choice of the energy storage media and the efficiency of the energy conversion devices. Recent advances in electrolyser and fuel cell technologies may make small-scale hydrogen buffered renewable energy systems a practical reality in the near term. A research team at the University of Victoria - Institute for Integrated Energy Systems (IESVic) is developing a flexible distributed, laboratory-scale energy system called IRENE (Integrated Renewable Energy Experiment). The initial goal of this research is to explore the potential for constructing a regenerative energy system using early commercial and precommercial hydrogen storage and fuel cell energy conversion devices. Once implemented, research efforts will focus on the dynamic interactions between system elements ...
This document reviews the status of the knowledge on the oxidation of fuels below 400 deg C, in all its forms, including fuel rods, by examining the consequences of this reaction on the strength or ruin of the fuel rods during dry storage in air for a hundred years. The data available in the scientific literature, and the data acquired by CEA, are abundant on irradiated powders and pellets, but sparser for irradiated fuel fragments and for rods or sections of fuel rods. A bibliographic review is made to identify the morphological and structural changes, as well as the kinetic laws. An analysis and a summary is made with a concern to evaluate the risks of rod ruin by oxidation. The final section, in a few pages, addresses the essential lessons from this study. It presents: first, a summary of the main results of this review and its analysis, recommendations and remedies for storage; proposed research guidelines as well as precise topics, in order to fill out our ...
In response to the need for a comprehensive and consistent approach to the complex issue of mixed waste management, a generalized methodology for remediation of a mixed waste site has been developed. The methodology is based on requirements set forth in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the Resource Conservation and Recovery Act (RCRA) and incorporates ``lessons learned`` from process design, remediation methodologies, and remediation projects. The methodology is applied to the treatment of 32,000 drums of mixed waste sludge at the Oak Ridge K-25 Site. Process technology options are developed and evaluated, first with regard to meeting system requirements and then with regard to CERCLA performance criteria. The following process technology options are investigated: (1) no action, (2) separation of hazardous and radioactive species, (3) dewatering, (4) drying, and (5) solidification/stabilization. The first two ...
The Natural Gas Vehicle Challenge `92, organized by Argonne National Laboratory and sponsored by the US Department of Energy, the Energy, Mines, and Resources - Canada, the Society of Automotive Engineers, and many others, resulted in 20 varied approaches to the conversion of a gasoline-fueled, spark-ignited, internal combustion engine to dedicated natural gas use. Starting with a GMC Sierra 2500 pickup truck, donated by General Motors, teams of college and university student engineers strived to optimize Chevrolet V-8 engines operating on natural gas for improved emissions, fuel economy, performance, and advanced design features. This paper focuses on the results of the emission event, and compares engine mechanical configurations, engine management systems, catalyst configurations and locations, and approaches to fuel control and the relationship of these parameters to engine-out and tailpipe emissions of regulated exhaust constituents. Nine of the student-modified trucks passed the ...
Three test instruments are being evaluated to determine the feasibility of using photoacoustic technology for measuring unburned carbon in fly ash. The first test instrument is a single microwave frequency system previously constructed to measure photoacoustic signals in an off-line configuration. A second off-line instrument was constructed based in part on lessons learned with the first instrument, but which also expands the capabilities of the first instrument. Improvements include a control loop to allow more constant microwave power output and an ability to operate over a range of microwave frequencies. The third instrument, the on-line version of the fly ash monitor, has been designed, constructed, and initial efficiency tests have been conducted on the monitor's electrical components. This quarter focused on improving the signal strength of the accelerometer by increasing the power level of the microwaves that induced the thermo-elastic effect, and ...
Implementation of the Government Performance and Results Act of 1993 (GPRA) has provided a unique challenge for Federal Agencies, such as the Department of Energy (DOE) Office of Waste Management (OWM). While performance measurement, as required by GPRA, is new to Federal Agencies, private industry has applied it at all organizational levels to better manage their operations for some time. There has been significant discussion about how the private sector uses performance measures, but there have been very few empirical studies systematically examining their use. To gather information on comparable private industry practices, waste management industry firms were surveyed through questionnaires and follow-on interviews. Questionnaires were sent to 75 waste management firms throughout the United States and Canada. Twenty-four percent of the firms responded to the questionnaire and participated in the follow-on interviews. The questionnaires were typically completed by vice-presidents or ...
This booklet outlines the position of Manitoba's heat pump market with the objective of promoting the widespread use of geothermal heat pumps in the province. It makes reference to the size of the market, customer satisfaction with heat pumps, and opinion of key players in the industry regarding the heat pump market. The information in this booklet is drawn on market research and lessons learned in Europe and the United States. In October 2001, a group of key stakeholders in Manitoba's heat pump market attended an industry working meeting to address the issues of market barriers, market enablers and market hot buttons. Market barriers include the high cost of geothermal heat pumps, lack of consumer awareness, lack of consistent standards, and public perception that heat pumps are not reliable. Market enablers include the low and stable operating costs of geothermal heat pumps, high level of comfort, high quality and reliability of geothermal heat pumps, and ...
Versatility of the TRNSYS software program, the ease with which new components can be incorporated into the software, and its application to simulate heat pump systems was discussed. A case history was described in which the package, augmented by the addition of several recent large-scale heat pump projects, was used in calibrating a residential geothermal heat pump system at a military housing project in Fort Polk, LA. The project involved retrofitting over 4000 air source heat pumps with geothermal heat pumps in an energy savings performance contract. The calibration of the component models led to a system model which accurately predicts the performance of the geothermal heat pump. The lessons learned from the calibration exercise were used to help to predict the energy savings from one of the electric feeders at the base which serves some 200 of the 4000+ apartments. Energy savings estimates within one per cent of the actual measured post-retrofit energy ...
The authors map the route undertaken by the Project Management Office of the Gansu Basic Education Project (GBEP) in Gansu Province, China, in instituting measures to ensure good learning opportunities for children with special educational needs within the four poor counties benefiting from this DFID supported project. The main purpose of GBEP has been to increase enrolment and retention in these poor, minority areas so as to achieve universal basic education. As general enrolment increased so did that of pupils with special needs, the educational needs of which the schools began responding to in an unconscious way. However, at the start there was little understanding at the classroom and management levels of how to ensure access to learning as well as access to school. The authors map out the road to change and the methods undertaken to change practice at various management and classroom levels so as to enable schools to provide more adequately for these children. Experiences of and ...
The data and information collected for the Public Service Electric and Gas Company`s (PSE&G) electric vehicle demonstration program were intended to support and enhance DOE`s Electric and Hybrid Vehicle Site Operator Program. The DOE Site Operator Program is focused on the life cycle and reliability of Electric Vehicles (EVs). Of particular interest are vehicles currently available with features that are likely to be put into production or demonstrate new technology. PSE&G acquired eight GMC Electric G-Vans in 1991, and three TEVans in 1993, and conducted a program plan to test and assess the overall performance of these electric vehicles. To accomplish the objectives of DOE`s Site Operator`s test program, a manual data collection system was implemented. The manual data collection system has provided energy use and mileage data. From September 1991 to October 1994 PSE&G logged 69,368 miles on eleven test vehicles. PSE&G also demonstrated the EVs to diverse groups and ...
The National Ignition Facility (NIF) will be a U.S. Department of Energy (DOE) national center for inertial confinement fusion (ICF) and other research into the physics of high temperatures and high densities, and a vital element of the DOE`s nuclear weapons Stockpile Stewardship and Management Program. It will be used by scientists from a numerous different institutions and disciplines to support research advancements in national security, energy, basic science, and economic development. Multiple powerful laser beams will `ignite` small fusion targets, helping liberate more energy than is required to initiate the fusion reactions. This paper discusses the Design for Environment process for NIF, some of the subsequent activities resulting from the initial study, and a few of the lessons learned from this process. Subsequent activities include the development of a Pollution Prevention and Waste Minimization Plan (P2/WMin) for the facility, which includes Pollution ...
This paper provides an overview of environmental cleanup at the Los Alamos National Laboratory (LANL) and some of the unique aspects and challenges. Cleanup of the 65-year old Department of Energy Laboratory is being conducted under a RCRA Consent Order with the State of New Mexico. This agreement is one of the most recent cleanup agreements signed in the DOE complex and was based on lessons learned at other DOE sites. A number of attributes create unique challenges for LANL cleanup -- the proximity to the community and pueblos, the site's topography and geology, and the nature of LANL's on-going missions. This overview paper will set the stage for other papers in this session, including papers that present: Plans to retrieve buried waste at Material Disposal Area B, across the street from oen of Los Alamos' commercial districts and the local newspaper; Progress to date and joint plans with WIPP for disposal of the remaining inventory of ...
CANDU reactors developed under Canadian licensing regulations that placed the primary responsibility for safety on the licensee. The Atomic Energy Control Board (AECB), Canada's nuclear regulatory agency, state in their regulations what is expected in terms of safety performance so that designers are free to propose the best means of meeting this performance. This goal-oriented approach, besides encouraging innovation, allowed CANDU to be licensed in other jurisdictions. The latest design - the large, single unit, CANDU 9 - explicitly incorporates licensability in Canada through a formal AECB review of the design; lessons learned from licensing CANDU 6 in Asian countries, particularly with Wolsong 2, 3 and 4 in Korea, and more recently with Qinshan in China; utility requirements for modem evolutionary plants; and emerging international standards for safety, sponsored or issued by the IAEA. By combining the assurance of acceptability in Canada with ...
CANDU reactors developed under Canadian licensing regulations that placed the primary responsibility for safety on the licensee. The Atomic Energy Control Board (AECB), Canada's nuclear regulatory agency, state in their regulations what is expected in terms of safety performance so that designers are free to propose the best means of meeting this performance. This goal-oriented approach, besides encouraging innovation, allowed CANDU to be licensed in other jurisdictions. The latest design - the large, single unit, CANDU 9 - explicitly incorporates licensability in Canada through a formal AECB review of the design; lessons learned from licensing CANDU 6 in Asian countries, particularly with Wolsong 2, 3 and 4 in Korea, and more recently with Qinshan in China; utility requirements for modem evolutionary plants; and emerging international standards for safety, sponsored or issued by the IAEA. By combining the assurance of acceptability in Canada with compliance with ...
Because there are more than 101 million residential households in the United States today, it is not surprising that existing residential buildings represent an extremely large source of potential energy savings. Because thousands of these homes are renovated each year, Building America is investigating the best ways to make existing homes more energy-efficient, based on lessons learned from research in new homes. The Building America program is aiming for a 20%-30% reduction in energy use in existing homes by 2020. The strategy for the existing homes project of Building America is to establish technology pathways that reduce energy consumption cost-effectively in American homes. The existing buildings project focuses on finding ways to adapt the results from the new homes research to retrofit applications in existing homes. Research activities include a combination of computer modeling, field demonstrations, and long-term monitoring to support the development of ...
This article, published in issue 80 of 'l'ACROnique du nucleaire', aims to retrace the early steps in the consideration of the possibility of a nuclear accident in France, with the inclusion of 'non-institutional' participants and applying the lessons learned in Belarus in the contaminated territories around the Chernobyl nuclear power plant. After a review of the origin of the involvement of the Association pour le Controle de la Radioactivite dans l'Ouest (ACRO) in addressing post-accident issues alongside the populations living in an environment polluted by radioactivity, it discusses, from the critical viewpoint of an NGO, the context and the working method adopted for this examination. This is followed by some key elements of the programme and unresolved questions about the available body of knowledge which motivates research and about the method adopted for the work. The conclusion, moderately optimistic, ...
Due to the recent catastrophic energy system failures in California along with those in the North-Eastern US and Southern Canada, London, and Italy, the time has come to proclaim the failure of deregulation, privatization or liberalization and propose a new energy system. This book shows in the first section, how five precipitating forces led to the deregulation debacle in California: (1) major technological changes and commercialization, (2) regulatory needs mismatched to societal adjustments, (3) inadequate and flawed economic models, (4) lack of vision, goals, and planning leading to energy failures, and (5) failure and lack of economic regional development. The second half of the book, examines how 'civic market', new economic models, and planning for complexity as sustainable economic development transformed in California, the same five forces to create an 'agile energy system' based on renewable energy generation, hybrid or combined and ...
In order to consider some procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions and in accordance with information contained in international reports elaborated by International Atomic Energy Agency (IAEA) and of the data base availability by the European group Radiation Oncology Safety Information System (ROSIS) on the events, a research of the occurred errors was performed. For the evaluation of the incidents a data base based in the ROSIS and added plus a parameter was created 'type of error'. All the stored data make possible the evaluation of the 839 incidents in terms of frequency of the type of error, the process of detention, the number of reached patients and the degree of severity. Of the 50 types of found errors, the type of error more frequently was 'incorrect treatment coordinate', confirmed with the data of literature and representing 28,96 por cent of the total of the ...
Concept Exploration (CE) experiments within the Innovative Confinement Concept Program have a unique role which impacts their contributions to the development of fusion energy. As stated in the FESAC ''Report on Alternate Concepts:'' These [CE] programs are aimed at innovation and basic understanding of relevant scientific phenomena. The emphasis on innovation motivates their application to the search for a better fusion reactor configuration. In addition, because of their unique character the CE experiments offer excellent opportunities to couple fusion-plasma physics to other sciences. A recent example of coupling is the fusion self-organized plasmas to reconnection physics and extra-terrestrial plasmas. Perhaps of even greater importance is the education of the future scientists needed for developing fusion energy. The CE experiments, both at universities and national labs, are of a size students can ''get their hands ...
Renewable Energy Technologies (RETS) have over the years become an integral part of the energy supply chain in most developed countries. Recent projections show that 13.5% of the world's primary energy supply comes from renewable and this figure has an aggregated annual growth rate of 16%. Wind has the highest annual growth rate of 22% while the least annual growth rate of 2% is for hydropower. The main push for renewable like wind in the OECD countries are environmental concerns and the business aspect in power generation. The situation is however completely different in Africa, where the thrust for RETs is developmental based. Although the continent has abundant renewable energy resources like solar, biomass, wind and hydro potential, they have remained largely unexploited. Several efforts have been made to help African countries like Zimbabwe to exploit such resources. The main objectives of this country study included review of Zimbabwe's development of past RETs, ...
As a condition of accession into the European Union (EU), Lithuania is committed to the closure and decommissioning of Ignalina NPP comprising two RBMK-1500 reactor units (Fig. 1). It was agreed in a special protocol to the Accession Treaty that, in return for adequate EU financial assistance, Unit 1 would be closed before 2005 and Unit 2 by the end of 2009. The first unit was duly shut down on December 31, 2004. Lithuania, which has borders with Russia (Kaliningrad territory), Poland, Latvia and Belarus, spent fifty years as part of the Soviet Union and was deeply integrated into its economy and electrical infrastructure. At the break-up of the USSR, Lithuania inherited electricity generating capacity designed to supply the north-west region including ownership of Ignalina NPP located in the north-east of the country. Ignalina NPP Unit 1 was commissioned in 1983, Unit 2 in 1987; the planned lifespan of each unit was 30 years. Construction of a third unit was started but never ...
Satellite imagery is a cost-effective tool for creating and updating basemaps of coastal zones, especially where existing maps and aerial photographs are unavailable, are out-of-date, or provide limited information. Reliable maps of coastal zones are particularly important for oil spill modelling programs. Color IR (multispectral) images with 20m x 20m ground resolution and black & white (panchromatic) images with 10m x 10m ground resolution of many coastlines around the globe have been acquired from 1986 to present by SPOT Image Corporation. We have digitally merged same-day SPOT panchromatic and multispectral imagery to provide maximum spatial resolution and permit excellent color differentiation of coastal zone features. This combination adequately discriminates individual features, including pipelines, offshore platforms, storage tanks, jetties, and shoreline type. The SPOT images were interpreted within a workstation environment and the coastline interpretation map (a digital ...
The purpose of this presentation is to provide an in-depth discussion of the possible evolution of unbundling of services in a competitive environment. The author discusses unbundling from both a technical/engineering and an economic perspective. The main thrust of the talk is threefold: (a) that in the long run the potential for unbundling of services is extremely large from an engineering perspective; (b) that the form of the initial industry structure will have an important impact on the extent of service unbundling; and (c) that unbundling of wholesale related services is where most of the initial demand will be. (A) Engineering Perspectives on Unbundling: A large proportion of ancillary services can be provided in a competitive framework with current technologies. The author discusses those that current technologies may not facilitate such a decentralized approach. (B) The relation between unbundling and industry structure: Not all industry structures provide the same incentives ...
An essential aspect of control centre design is the need to characterize: plant functions and their inter-relationships to support the achievement of operational goals, and roles for humans and automation in sharing and exchanging the execution of functions across all operational phases. Function analysis is a design activity that has been internationally accepted as an approach to satisfy this need. It is recognized as a fundamental and necessary component in the systematic approach to control centre design and is carried out early in the design process. A function analysis can provide a clear basis for: the control centre design for the purposes of design team communication, and customer or regulatory review, the control centre display and control systems, the staffing and layout requirements of the control centre, assessing the completeness of control centre displays and controls prior and supplementary to mock-up walkthroughs or simulator evaluations, and the design of operating ...
On 21 October 1994, three brothers entered a waste repository at Tammiku, Estonia, without authorization and removed a metal container enclosing a caesium-137 source. During the removal the source was dislodged and fell to the ground. One of the men picked up the source, placed it in his pocket and took it to his home in the nearby village of Kiisa. Very soon after entry into the repository he began to feel ill, and few hours later he began to vomit. The man was subsequently admitted to hospital with severe injuries to his leg and hip and died on 2 November 1994. The injury and subsequent death were not attributed to radiation exposure, and the source remained in the man's house with his wife and stepson and the boy's great-grandmother. The boy was hospitalized on 17 November with severe burns on his hands, and these were identified by a doctor as radiation induced. The authorities were alerted, and the Estonian Rescue Board recovered the source from the house. The source was returned ...
The UK fully supports the objective of the Joint Convention on the Safety of Spent Fuel Management and on the Safety of Radioactive Waste Management to achieve and maintain a high level of safety worldwide in spent fuel and radioactive waste management, through the enhancement of national measures and international co-operation, including where appropriate, safety-related co-operation. The UK's Health and Safety Executive, through its Nuclear Safety Directorate (NSD), has been committed to the Convention since the initial negotiations to set up the Convention and provided the president of the first review meeting in 2003. It would be wrong of any nation to believe that they have all the best solutions to managing spent fuel and radioactive waste. The process of compiling reports for the Convention review meetings provides a structured process through which every contracting party can review its provisions against a common set of standards and identify for itself possible areas of ...
The strategy for building SASOL plants reflects a commitment to long-range planning. The first plant, which represented a large investment for a moderate production capacity, was built to establish a technology for reducing South Africa's dependence on imported motor fuels. After the success of the plant, SASOL made plans for a larger plant, which had to be justified solely on economic grounds. At that time, petroleum crude was cheap and plentiful, and the second plant was cancelled. But when OPEC formed and the price of petroleum crude was increased, the South African government reconsidered the plans for another SASOL plant. Furthermore, because the cost of fuels produced at Sasol I proved to be significantly insensitive to inflation and future OPEC price increases were expected, SASOL projected that a new, larger plant should make a profit within a few years after its initial operation. But OPEC prices and inflation have risen even faster than anticipated, and the products ...
The strategy for building SASOL plants reflects a commitment to long-range planning. The first plant, which represented a large investment for a moderate production capacity, was built to establish a technology for reducing South Africa's dependence on imported motor fuels. After the success of the plant, SASOL made plans for a larger plant, which had to be justified solely on economic grounds. At that time, petroleum crude was cheap and plentiful, and the second plant was cancelled. But when OPEC formed and the price of petroleum crude was increased, the South African government reconsidered the plans for another SASOL plant. Furthermore, because the cost of fuels produced at Sasol I proved to be significantly insensitive to inflation and future OPEC price increases were expected, SASOL projected that a new, larger plant should make a profit within a few years after its initial operation. But OPEC prices and inflation have risen even faster than anticipated, and the products ...
This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power ...
During the first 18 months of this project, four experimental subtasks were to have begun but only one of these was to have been completed. Additionally, five modeling subtasks were scheduled to begin, four of which were to have been completed. We are on schedule for all but one of these subtasks. All four experimental tasks are progressing on schedule. Initial durability tests were completed. The conclusions drawn from this first round of durability tests are being used to design the next set of tests. Initial baseline engine data were acquired and showed that the engine selected for this task behaves as hoped. However, the dyno controller is inadequate. The engine will be moved to another dyno during the near future. The modeling tasks are also progressing well. A model for the dynamic response of the ignition circuit was developed and validated. Two technical papers resulting from this model were submitted for publication. Development of a model for the railplug ignition process was ...
The title of the workshop, ''The QCD Phase Transitions'', in fact happened to be too narrow for its real contents. It would be more accurate to say that it was devoted to different phases of QCD and QCD-related gauge theories, with strong emphasis on discussion of the underlying non-perturbative mechanisms which manifest themselves as all those phases. Before we go to specifics, let us emphasize one important aspect of the present status of non-perturbative Quantum Field Theory in general. It remains true that its studies do not get attention proportional to the intellectual challenge they deserve, and that the theorists working on it remain very fragmented. The efforts to create Theory of Everything including Quantum Gravity have attracted the lion share of attention and young talent. Nevertheless, in the last few years there was also a tremendous progress and even some shift of attention toward emphasis on the unity of non-perturbative phenomena. ...
The title of the workshop, ''The QCD Phase Transitions'', in fact happened to be too narrow for its real contents. It would be more accurate to say that it was devoted to different phases of QCD and QCD-related gauge theories, with strong emphasis on discussion of the underlying non-perturbative mechanisms which manifest themselves as all those phases. Before we go to specifics, let us emphasize one important aspect of the present status of non-perturbative Quantum Field Theory in general. It remains true that its studies do not get attention proportional to the intellectual challenge they deserve, and that the theorists working on it remain very fragmented. The efforts to create Theory of Everything including Quantum Gravity have attracted the lion share of attention and young talent. Nevertheless, in the last few years there was also a tremendous progress and even some shift of attention toward emphasis on the unity of non-perturbative phenomena. ...
Among KEPCO's 9 nuclear power units, Korea Nuclear Unit No. 3, the Wolsung Nuclear Power Plant is the only CANDU-PHWR Unit, while the rest of 8 others are PWR units. The unit was designed by Atomic Energy of Canada, Ltd. of Canada, who also performed overall project management for the plant construction under the provisions and arrangement of the relevant contracts. The gross electrical output of the plant is 678.7 MWe and thermal output of the reactor is 2061 MWth. While these figures lead to lower plant efficiency than LWR counterparts, unit energy cost for fuel is more favorable than LWRs because natural uranium is utilized for the fuel bundles, some of which are already being fabricated domestically. Annual capacity factors for 1983 and 1984 could have been improved, if two major planned outages for the modification works on steam generator internals and one major forced outage from the heavy water spill incident could be eliminated. The heavy water spill incident in ...
Recently, US energy service companies (ESCOs) have begun to actively explore markets outside the US. Despite the needs of many countries for ESCO involvement, ESCOs face many challenges (i.e., marketing, financial, institutional, political and cultural barriers). Consequently, most of these firms pursue international project opportunities very selectively due to the costs and risks associated with project development. Despite these barriers, some ESCOs view international work as a strategic expansion of their business, assuming that there will be adequate business in the future to repay them for their initial investment. In this paper, the authors present the findings from a recently completed study on the proposed development of an ESCO industry in Japan. The study was based on four sources of information: (1) a review of the published and unpublished literature on ESCOs; (2) interviews with 26 ESCOs in the US, the US Department of Energy, and the National Association of Energy ...
An internal flooding (IF) risk assessment refers to the quantitative probabilistic safety assessment (PSA) treatment of flooding as a result of pipe and tank breaks inside the plants, as well as from other recognized flood sources. The industry consensus standard for Internal Events Probabilistic Risk Assessment (ASME-RA-Sb-2005) includes high-level and supporting technical requirements for developing internal flooding probabilistic risk assessment (IFPRA). This industry standard is endorsed in Regulatory Guide 1.200, Revision 1 as an acceptable approach for addressing the risk contribution from IF events for risk informed applications that require U.S. Nuclear Regulatory commission (NRC) approval. In 2006, EPRI published a draft report for IFPRA that addresses the requirements of the ASME PRA consensus standard and have made efforts to refine and update the final EPRI IFPRA guideline. Westinghouse has performed an IFPRA analysis for several nuclear power plants (NPPs), such as Watts ...
Commonly used EV battery tests are not very suitable for testing hybrid vehicle batteries, which may be primarily intended to supply vehicle acceleration power. The capacity of hybrid vehicle batteries will be relatively small, they will typically operate over a restricted range of states-of-charge, and they may seldom if ever be fully recharged. Further, hybrid propulsion system designs will commonly impose a higher regeneration content than is typical for electric vehicles. New test methods have been developed for use in characterizing battery performance and life for hybrid vehicle use. The procedures described in this paper were developed from the requirements of the government-industry cooperative Partnership for A New Generation of Vehicles (PNGV) program; however, they are expected to have broad application to the testing of energy storage devices for hybrid vehicles. The most important performance measure for a high power battery is its pulse power capability as a function of ...
In 1994, the United States Department of Energy, the United States electric utilities and the geothermal heat pump (GeoExchange) industry formed a non-profit collaborative effort called the Geothermal Heat Pump Consortium (GHPC). The objectives were the reduction and/or elimination of 1.5 million metric tons of carbon equivalent per year and making geothermal heat pumps a significant part of the Heating Ventilation Air Cooling (HVAC) industry. Federal funding of 35 million dollars over six years was matched by 65 million dollars of private sector funds to attain these objectives and create a self-sustainable GeoExchange market. The major accomplishments of this endeavour, as well as the lessons learned were presented in this paper. The infrastructure was strengthened, first cost was reduced, and awareness of the technology was increased over the past six years as a result of the efforts deployed by the GHPC. More than 500,000 units are already installed, which ...
This report provides a chronological history of policies and practices relating to the management of radioactive waste for which the US Atomic Energy Commission and its successor agencies, the Energy Research and Development Administration and the Department of Energy, have been responsible since the enactment of the Atomic Energy Act in 1946. The defense programs and capabilities that the Commission inherited in 1947 are briefly described. The Commission undertook a dramatic expansion nationwide of its physical facilities and program capabilities over the five years beginning in 1947. While the nuclear defense activities continued to be a major portion of the Atomic Energy Commission`s program, there was added in 1955 the Atoms for Peace program that spawned a multiplicity of peaceful use applications for nuclear energy, e.g., the civilian nuclear power program and its associated nuclear fuel cycle; a variety of industrial applications; and medical research, diagnostic, and ...
Probabilistic assessment methods can be used to identify specific plant vulnerabilities. Application of such methods can also facilitate selection among system design alternatives available for safety enhancements. The quality of assessment results is however strongly dependent on realistic and accurate input data for modelling of system component behaviour and failure modes during conditions to be assessed. Use of conservative input data may not lead to results providing guidance on safety upgrades. Adequate input data for probabilistic assessments seems to be lacking for at least failure modes of some electrical components when exposed to a fire. This report presents an attempt to improve the situation with respect to such input data. In order to take advantage of information in existing documentation of fire incident occurrences some of the lessons learned from the fire at Browns Ferry Nuclear Power Plant on March 22, 1975 are discussed in this report. Also a ...
A parallel event to the eleventh Conference of Parties (COP) to the United Nations Framework Convention of Climate Change was held to demonstrate examples of adaptation from around the world in the areas of food security, water resources, coastal zones, and communities/infrastructure. Panels on each theme presented examples from developing countries, countries in economic transition, and developed countries. These 4 themes were chosen because both mitigation and adaptation are essential to meeting the challenge of climate change. The objective of the event was to improve the knowledge of Canada's vulnerabilities to climate change, identify ways to minimize the negative effects of future impacts, and explore opportunities that take advantage of any positive impacts. This third session focused on how coastal communities are adapting to climate change in such places as Quebec, the Caribbean, and small Island States. It also presented the example of how a developed country became ...
Embracing the notion of going green, an affluent school district in Pennsylvania spent $83 million as part of the high school's renovation and expansion project. The three-level addition is now equipped with self-dimming lights, energy-efficient windows, a rooftop solar water heater, and a geothermal cooling and heating system. As a bonus for going green, the school district received a $250,000 grant from the Pennsylvania Department of Environmental Protection. The district used that money to create an information center in the lobby of the building where a touch-screen computer provides students, staff, and visitors with data related to the operation of the school's energy-efficient water and electrical systems. The system will graphically depict utility use over the course of a year. The monitoring system and touch-screen computer can turn this school into a living lab, with science, math, and economics teachers using the data as teaching tools within classrooms. Teachers can also ...
Some of the methodologies, techniques, dependencies and lessons learned regarding the year 2000 (Y2K) project currently underway at PanCanadian are described. The Y2K problem, which is a date related malfunction associated with the turn of the century, may affect computers and automated control systems. The cost of fixing this world wide problem ranges from $52 billion to $2 trillion. At PanCanadian, central to ensuring that the entire corporation is ready for the Year 2000 is a dedicated project team in the information technology (IT) department who manage all the life-cycle software for the company. IT staff purchase, install and remove all obsolete software and data. Inventory, testing and remediation of all software, hardware and embedded systems are the basis of the plan of action adopted by the I.T. Y2K project team. Dealing with Y2K problems of business partners, and planning for business interruption are special problems for which different approaches have ...
Los Alamos National Laboratory (LANL) was established during World War II with a single mission -- to design and build an atomic bomb. In the 65 years since, nuclear weapons physics, design and engineering have been the Laboratory's primary and sustaining mission. Experimental and process operations -- and associated cleanout and upgrade activities -- have generated a significant inventory of transuranic (TRU) waste that is stored at LANL's Technical Area 54, Material Disposal Area G (MDA G). When the Waste Isolation Pilot Plant (WIPP) opened its doors in 1999, LANL's TRU inventory totaled about 10,200 m{sup 3}, with a plutonium 239-equivalent curie (PE Ci) content of approximately 250,000 curies. By December 2008, a total of about 2,300 m3 (61,000 PE Ci) had been shipped to WIPP from LANL. This has resulted in a net reduction of about 1,000 m{sup 3} of TRU inventory over that time frame. This paper presents progress in dispositioning legacy and ...
In a 4-wk oral toxicity study, 4-wk-old male and female Wistar rats were exposed to a combination of arbitrarily chosen chemicals comprising sodium metabisulphite, Mirex, Loperamide, metaldehyde, di-n-octyltin dichloride, stannous chloride, lysinoalanine and potassium nitrite. The dose levels used were based on the "no-observed-adverse-effect level" (NOAEL) and the "minimum-observed-adverse-effect level" (MOAEL) of the individual compounds obtained in similar studies with Wistar rats previously performed at TNO-CIVO, and comprised 0 (controls), 1/10 and 1/3 of the NOAEL, the NOAEL and the MOAEL. In comparison with the adverse effects of the individual compounds, both more severe and less severe adverse effects were observed at the MOAEL of the combined compounds, indicating interaction of effects at this exposure level. Slightly decreased haemoglobin content and slightly increased relative kidney weight were the only treatment-related adverse effects seen in the NOAEL group. In the ...
The focus of this study is on the preparatory detection of uncertain net greenhouse gas (GHG) emission changes (also termed emission signals) under the Kyoto Protocol. The crucial question to be addressed is: How well do we need to know net emissions if we want to detect a specified emission signal after a given time? No restrictions exist as to what concerns the net emitter, which may be any GHG source or sink. Annex I countries are chosen as net emitters, simply for reasons of data availability and because of the excellent possibility of comparing net emitters (inter-country comparison). The countries' emissions - in an increasing number of cases even their uncertainties - are available permitting the application of preparatory signal detection techniques, which are suited to address the aforementioned question. We currently discuss four hierarchically-ordered detection concepts to assess emission signals in a preparatory manner, that is, at two predefined points in time, t1 ...
Full text: As one of the Top 5 utilities in Europe, Rheinisch-Westfaelisches Elektrizitaetswerk AG, FWB: RW, RWE, operates a diversified generating capacity of about 45 GW; RWE Power alone generates over 30 GW. Besides a share of approximately 20% nuclear power, a large proportion of the generating base is in lignite and hard coal. RWE has an ambitious, Euro10 bn newbuild program of about 10 GW modern fossil fired plants and further expansion plans across Europe. By 2012, RWE intends to invest between Euro 15 and 20 bn outside Germany.The European Union has a challenging policy to increase the share of renewables, improve energy efficiency, and reduce greenhouse gases by 2020. At the same time, ageing power plants need to be replaced. This requires an enormous investment program across Europe. Nuclear power therefore, as a proven technology with low lifecycle carbon emissions and reasonable lifecycle cost, is a crucial contributor to achieve Europe's 2020 goals. Accordingly, most ...
This document gathers the available presentations (articles and transparencies) given at this annual meeting, the 2007 topic of which was the technological, geopolitical, economical, environmental, societal and development stakes of energy. 1 - technological stakes - which energies for the future: new energies, illusion or solution of the future; the Lorraine region, an energy land: strategies and stakes for a sustainable development; from China to Brazil: understanding the nuclear energy revival; hydroelectric power: renewable and sustainable energy; renewable energies and environment protection: the contribution of biofuels; wind power in Germany between success and contestation; 2 - geopolitical stakes - energy levier of power: the Gulf of Guinea hydrocarbons: between development and geopolitics; the complex evaluation of resources and reserves between technology, market and geopolitics; the new Bakou-Tbilissi-Ceyhan pipeline: what impacts for Turkey and the European Union; 3 - ...
A large number of proven technical solutions exists for the use of renewable energies (RE). However, their dissemination is still too slow to meet the political goal of substituting 12 % of the primary energy demand in the European Union by the year 2010. Even renewable energy systems (RES) with economic potential are only partly exploited. There is a long literature concerning the barriers to RE use. In particular it has become clear that the availability of finance and the forms and conditions upon which it is lent have a major impact on RE deployment. An area of importance is the deficiency of appropriate ownership forms and properly adapted financing instruments in certain countries. Moreover, different regulations and institutional barriers in the European countries hinder the free flow of capital for RES within the European common market. On the other hand, solutions have been developed very successfully in individual countries. Differences in cultures and institutions have ...
At the end of 2005, Robert D. Felner was riding high. A well-paid dean at the University of Louisville, he had just secured a $694,000 earmarked grant from the U.S. Department of Education to create an elaborate research center to help Kentucky's public schools. The grant proposal, which Mr. Felner had labored over for months, made some impressive promises. On paper this all seemed plausible: From 1996 until 2003, Mr. Felner directed the University of Rhode Island's education school, where he helped create a well-regarded statewide research center. To put it gently, Mr. Felner did not duplicate that feat at Louisville. By the spring of 2008, all but $96,000 of the grant had been spent, but none of the tasks listed in Mr. Felner's proposal had been accomplished. Late in May 2008, he told his colleagues that he had been hired as chancellor of the University of Wisconsin-Parkside, effective August 1. During his final weeks at Louisville, Mr. Felner pressed his luck one last time. Even ...
In compliance with Article 20 of the sustainable radioactive materials and waste management act dated 28 June 2006, the CEA and AREVA are required every three years to revise the cost of decommissioning their facilities and to provide the necessary assets by constituting a dedicated fund. For the 2007 revision the CEA used ETE-EVAL V5. Similarly, AREVA reevaluated the cost of decontaminating and dismantling its facilities at La Hague, as the previous estimate in 2004 did not take into account the complete cleanup of all the structural work. ETE-EVAL V5 is a computer application designed to estimate the cost of decontamination and dismantling of basic nuclear installations (INB). It has been qualified by Bureau Veritas and audited. ETE-EVAL V5 has become the official software for cost assessment of CEA civilian and AREVA decommissioning projects. It has been used by the DPAD (Decontamination and Dismantling Projects Department) cost assessment group to estimate the cost of ...
A.C.R.O. (Association pour le Controle de la Radioactivite dans l Ouest) is a French non governmental organisation that operates a laboratory for radioactivity analysis. It was created in 1986 as a response to people demands for information and reliable, independent testing. The organisation mainly carries out missions of information and training for its correspondents and more generally for a wide audience, particularly for people who worry about problems of environment, health, management of radioactive waste and emissions. Thanks to its structure, it enables citizens to involve themselves together with scientists so as to gain access to information that was hither to reserved to specialists. The organisation can vouchsafe its independence from the diversity of its members and volunteers, as well as from the diversity of its money resources. Besides its headquarters situated on the city of Caen area (Normandy), three branches situated in North Normandy, in Touraine and North Cotentin ...