WorldWideScience
1

Synthetic Biology and Human Health: Potential Applications for Spaceflight  

Science.gov (United States)

Human space travelers experience a unique environment that affects homeostasis and physiologic

2011-01-01

2

Novel Antidrugabuse Peptide  

International Science & Technology Center (ISTC)

Natural Biologically Active HLDF6 Peptide as Potential Preparation for Correction of Different Drugabuse Forms

3

Technical Key Figures for Photo-biological Hydrogen Production by Micro-algae  

International Nuclear Information System (INIS)

One regenerative path to produce hydrogen is the photo-biological hydrogen production by the green micro-alga Chlamydomonas reinhardtii. This process can be divided into three phases: a growth phase, a phase in which the algae adapt from oxygen production and CO2-fixation to fermentative H2 production, and a phase in which H2 is produced. In a research project carried out at Ruhr-Universitat Bochum, a new developed flat panel bioreactor was investigated. A system analysis was conducted and energetic and environmental key figures were determined. The intention of this assessment on a very early technological stage was to collect first technical data in order to classify the current technological status of the photo-biological H2 production to identify future potentials and to uncover weaknesses. For this reason the key figures were evaluated for the status quo and for two scenarios which allow an outlook ...

2006-06-13

4

Investigation of xenotropic murine leukemia virus-related virus (XMRV) in human and other cell lines.  

Science.gov (United States)

Xenotropic murine leukemia virus-related virus (XMRV) was discovered in human prostate tumors and later in some chronic fatigue syndrome (CFS) patients. However, subsequent studies have identified various sources of potential contamination with XMRV and other murine leukemia virus (MLV)-related sequences in test samples. Biological and nucleotide sequence analysis indicates that XMRV is distinct from known xenotropic MLVs and has a broad host range and cell tropism including human cells. Therefore, it is prudent to minimize the risk of human exposure to infection by evaluating XMRV contamination in cell lines handled in laboratory research and particularly those used in the manufacture of biological products. Nested DNA PCR assays were optimized for investigating XMRV gag and env sequences in various cell lines, which included MRC-5, Vero, HEK-293, MDCK, HeLa, and A549, that may be used in the ...

2011-10-11

5

Overview of the environmental concerns of coal transportation  

Energy Technology Data Exchange (ETDEWEB)

More than 30 environmental concerns were analyzed for the transportation of coal by rail, roads (trucks), high voltage transmission lines (that is, from mine-mouth generating plants to distribution networks), coal slurry pipelines, and barges. The following criteria were used to identify these problems: (1) real physical environmetal impacts for which control technologies must be developed, or regulation made effective where control technologies presently exist; (2) the level of impact is uncertain, although the potential impact may be moderate to high; (3) the concerns identified by the first two criteria are specific to or exacerbated by coal transportation. Generic transportation problems are not included. The significant environmental problems identified as a result of this study are: (1) rail transport - community traffic disruption and human health, safety, and habitat destruction; (2) coal haul ...

1980-02-01

6

Occurrences and distributions of branched alkylbenzenes in the Dongsheng sedimentary uranium ore deposits, China  

British Library Electronic Table of Contents (United Kingdom)

A series of branched alkylbenzene ranging from C15 to C19 with several isomers (2?5) at each carbon number were identified in sediments from the Dongsheng sedimentary uranium ore deposits, Ordos Basin, China. The distribution patterns of the branched alkylbenzenes show significant differences in the sample extracts. The branched alkylbenzenes from organic-rich argillites and coals range from C15 to C19 homologues, in which the C17 or C18 dominated. On the other hand, the C19 branched alkylbenzenes dominated in the sandstone/siltstone extracts. The obvious differences of the branched alkylbenzene distributions between the uranium-host sandstones/siltstones and the interbedded barren organic-rich mudstones/coals probably indicate their potential use as biological markers associated with part...

2010-01-01

7

Is XMRV a causal virus for prostate cancer?  

British Library Electronic Table of Contents (United Kingdom)

The potential association between xenotropic murine leukaemia virus-related gammaretrovirus (XMRV) and prostate cancer (PCa) has been documented since 2006. It is important for furthering our understanding of the biological mechanisms of PCa to ascertain whether this association is causal. To summarize the available information on the epidemiological and laboratory findings of the association, we conducted a literature search of the PubMed electronic database (from March 2006 to February 2011) to identify relevant published studies that examined the association between XMRV and PCa. Although several studies showed the positive association between XMRV and PCa, more recent studies did not support this conclusion. The positive findings might be due to contamination of human samples. Further ...

2011-01-01

8

Multilevel support vector regression analysis to identify condition-specific regulatory networks  

UK PubMed Central (United Kingdom)

Motivation: The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify...Full Text Available

2010-06-01

9

Detecting exposure to environmental organic toxins in individual cells: towards development of a micro-fabricated device  

Energy Technology Data Exchange (ETDEWEB)

A new method is being developed to quickly screen for the human exposure potential to polycyclic aromatic hydrocarbons (PAHs) and organochlorines (OCs). The development involves two key elements: identifying suitable signals that represent intracellular changes that are specific to PAH and OC exposure, and constructing a device to guide the biological cell growth so that signals from individual cells are consistent and reproducible. We are completing the identification of suitable signals by using synchrotron radiation-based (SR) Fourier-transform infrared (FTIR) spectromicroscopy in the mid-infrared region (4000-400 cm-1). Distinct changes have been observed in the IR spectra after treatment of human cells in culture medium with PAHs and OCs. The potential use of this method for detecting exposure to PAHs and OCs has been tested and compared to a reverse transcription polymerase chain reaction (RT-PCR) ...

1999-01-10

10

Physical mechanisms of biological molecular motors  

Energy Technology Data Exchange (ETDEWEB)

Biological motors generally fall into two categories: (1) those that convert chemical into mechanical energy via hydrolysis of a nucleoside triphosphate, usually adenosine triphosphate, regarded as life's chemical currency of energy and (2) membrane bound motors driven directly by an ion gradient and/or membrane potential. Here we argue that electrostatic interactions play a vital role for both types of motors and, therefore, the tools of physics can greatly contribute to understanding biological motors.

2009-03-01

11

Neutrons in Biology. A satellite meeting of the IUPAB/EBSA biophysics congress  

Energy Technology Data Exchange (ETDEWEB)

This meeting focussed on the study of the structure and dynamics of biological molecules, with particular emphasis on neutron and complementary methods as well as related enabling technologies. The program covered biological problems that are being addressed by neutron scattering and those where there is the potential to do so in the future. This document provides the abstracts of the different presentations. (A.L.B.)

2005-07-01

12

Dynamic neuronal ensembles: Issues in representing structure change in object-oriented, biologically-based brain models  

Energy Technology Data Exchange (ETDEWEB)

This paper describes the structure of dynamic neuronal ensembles (DNEs). DNEs represent a new paradigm for learning, based on biological neural networks that use variable structures. We present a computational neural element that demonstrates biological neuron functionality such as neurotransmitter feedback absolute refractory period and multiple output potentials. More specifically, we will develop a network of neural elements that have the ability to dynamically strengthen, weaken, add and remove interconnections. We demonstrate that the DNE is capable of performing dynamic modifications to neuron connections and exhibiting biological neuron functionality. In addition to its applications for learning, DNEs provide an excellent environment for testing and analysis of biological neural systems. An example of habituation and hyper-sensitization in biological ...

1996-12-31

13

Sugarcane pests and their management  

Science.gov (United States)

This book chapter discusses sugarcane culture and history, describes arthropod biologies and injury, and identifies sugarcane pest management factors to consider for people interested in commercial sugarcane production. Arthropod groups include 10 orders and 40 families. Sugarcane pest management ...

14

Proteome of human colon cancer stem cells: A comparative analysis  

UK PubMed Central (United Kingdom)

AIM: To isolate and identify the biological characteristics of human colon cancer stem cells (SW1116 cells) and further study their proteome.METHODS: SW1116 cells were isolated and cultured with...Full Text Available

2011-03-14

15

In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression  

UK PubMed Central (United Kingdom)

Mouse models have dramatically improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic...Full Text Available

2009-10-01

16

Genome-Wide Identification and Evolutionary Analysis of the Animal Specific ETS Transcription Factor Family  

UK PubMed Central (United Kingdom)

The ETS proteins are a family of transcription factors (TFs) that regulate a variety of biological processes. We made genome-wide analyses to explore the classification of the ETS gene family. We identified...Full Text Available

17

DECOMP: A PDB decomposition tool on the web  

UK PubMed Central (United Kingdom)

The protein databank (PDB) contains high quality structural data for computational structural biology investigations. We have earlier described a fast tool (the decomp_pdb tool) for identifying and...Full Text Available

18

Biological control of take-all in wheat by endophytic Bacillus subtilis E1R-j and potential mode of action  

British Library Electronic Table of Contents (United Kingdom)

The bacterial strain E1R-j, isolated as an endophyte from wheat roots, exhibited high antifungal activity to Gaeumannomyces graminis var. tritici (Ggt). Strain E1R-j was identified as Bacillus subtilis based on morphological, physiological and biochemical methods as well as on 16S rDNA analysis. This strain inhibited mycelium growth in vitro of numerous plant pathogenic fungi, especially of Ggt, Coniothyrium diplodiella, Phomopsis sp. and Sclerotinia sclerotiorum. In greenhouse experiments, soil drenches with cell densities of 106, 109 and 1012CFU ml-1 E1R-j reduced significantly take-all disease, caused by Ggt, in wheat seedling by 62.6%, 68.6% and 70.7%, respectively, compared to the inoculated control, 4weeks after sowing. Growth parameters such as lengths and fresh weights of roots and...

2009-01-01

19

Yeast as a Model System to Study Tau Biology  

Science.gov (United States)

Hyperphosphorylated and aggregated human protein tau constitutes a hallmark of a multitude of neurodegenerative diseases called tauopathies, exemplified by Alzheimer's disease. In spite of an enormous amount of research performed on tau biology, several crucial questions concerning the mechanisms of tau toxicity remain unanswered. In this paper we will highlight some of the processes involved in tau biology and pathology, focusing on tau phosphorylation and the interplay with oxidative stress. In addition, we will introduce the development of a human tau-expressing yeast model, and discuss some crucial results obtained in this model, highlighting its potential in the elucidation of cellular processes leading to tau toxicity.

2011-04-06

20

On vortices heating biological excitable media  

International Nuclear Information System (INIS)

An extension of the Hodgkin-Huxley mathematical model for the propagation of nerve signal which takes into account dynamical heat transfer in biological tissue is derived and fine tuned with existing experimental data. The medium is heated by Joule's effect associated with action potential propagation, leading to characteristic thermal patterns in association with spiral and scroll waves. The introduction of heat transfer-necessary on physical grounds-provides a novel way to directly observe the movement, regular or chaotic, of the tip of spiral waves in numerical simulations and possibly in experiments regarding different biological excitable media.

2009-11-30

21

Topological modeling of the reactive capacity and biological activity of some amino-polysaccharides  

British Library Electronic Table of Contents (United Kingdom)

The work is devoted to a microscopic analysis of the reactive capacity of chitin. An algorithm for modeling the deacetylation reaction in a monomeric unit of chitin is described. The reaction coordinate and the potential energy surface topography are determined taking into account the electron-vibrational interaction and low-symmetry perturbations within Jahn-Teller theory. Based on this algorithm, the topological modeling of the deacetylation process is performed for the first time and a mechanism of the biological activity of chitosan is proposed.

2011-01-01

22

The hemoglobins of the trematodes Fasciola hepatica and Paramphistomum epiclitum: A molecular biological, physico-chemical, kinetic, and vaccination study  

UK PubMed Central (United Kingdom)

The trematode Fasciola hepatica (Fa.he.) is a common parasite of human and livestock. The hemoglobin (Hb) of Fa.he., a potential immunogen, was chosen for characterization...Full Text Available

2008-10-01

23

Metabolic Engineering of Poly(3-Hydroxyalkanoates): From DNA to Plastic  

UK PubMed Central (United Kingdom)

Poly(3-hydroxyalkanoates) (PHAs) are a class of microbially produced polyesters that have potential applications as conventional plastics, specifically thermoplastic elastomers. A wealth of biological...Full Text Available

1999-03-01

24

INVERTEBRATE FAUNA ASSOCIATED WITH TORPEDOGRASS, PANICUM REPENS (CYPERALES: POACEAE), IN LAKE OKEECHOBEE, FLORIDA, AND ...  

Science.gov (United States)

... 154. By way of comparison, the aquatic weed Hygrophila polysperma (Roxb.) T. Anderson, a potential target for biological ... L. Sutton. 2000. Is the aquatic weed hygrophila, Hygrophila polysperma (Polemon...

25

A Hot New Twist to Hair Biology  

UK PubMed Central (United Kingdom)

The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers. TRPV1 was originally described on sensory neurons...Full Text Available

2005-04-01

26

A unified framework for biological evolution and stochastic quantization  

CERN Document Server

We investigate the profound relation between the equations of biological evolution and quantum mechanics by writing a biologically inspired equation for the stochastic dynamics of an ensemble of particles. Interesting behavior is observed which is related to a new type of stochastic quantization. We find that the probability distribution of the ensemble of particles can be decomposed into eigenfunctions associated to a discrete spectrum of eigenvalues. In absence of interactions between the particles, the out-of-equilibrium dynamics asymptotically relaxes towards the fundamental state. This phenomenon can be related with the Fisher theorem in biology. On the contrary, in presence of scattering processes the evolution reaches a steady state in which the distribution of the ensemble of particles is characterized by a Bose-Einstein statistics. In order to show a concrete example of this stochastic quantization we have solved ...

2010-01-01

27

Biological effects of radiowaves and microwaves  

Energy Technology Data Exchange (ETDEWEB)

Heat production in biological materials due to absorption of radiowaves and microwaves can be used in applications as diverse as cancer treatment and cooking. However, the hazards of overexposure range from hyperthermia to cataracts and internal burns. To maximize the clinical benefits and minimize potential hazards, the biological effects of radiowaves and microwaves must be understood. Dielectric measurements can be used to determine the extent of such effects in various applications and at various levels of exposure. The values of maximum permissible exposure levels that are likely to be recommended aeat production in biological materials due to absorption of radiowaves and microwaves can be used in applications as diverse as cancer treatment and cooking. However, the hazards of overexposure range from hyperthermia to cataracts and internal burns. To maximize the clinical benefits and minimize ...

1980-01-01

28

Bioactivity and corrosion properties of novel coatings containing strontium by micro-arc oxidation  

International Nuclear Information System (INIS)

Research highlights: The dental implant of titanium could be modified by anodic oxidation. It was found that incorporation of strontium ions into the matrix increase the bone formation. In this study, we try to investigate the effect of corrosion property and bioactivity on coatings containing strontium by anodic oxidation. The results suggest that coatings containing strontium on titanium by anodic oxidation has the potential to show the stability and bioactivity in the clinical use. - Abstract: Pure titanium (Ti) and titanium alloys are considered as bio-inert materials in clinical use. Bioactivity is the ability to induce bone-like apatite on the material surface. The micro-arc oxidation (MAO) technique is an effective method for improving the surface properties of titanium. The aim of this study was to investigate the bioactivity and corrosion behavior of MAO coatings containing strontium, which is beneficial for biological performance. The ...

2010-10-22

29

Potentially Inappropriate Prescribing of Benzodiazepines for Older Adults and Risk of Falls During a Hospital Stay: A Descriptive Study  

UK PubMed Central (United Kingdom)

Background:Falls have been identified as a potential adverse event associated with the administration of psychotropic medications to older patients.Objective:The...Full Text Available

2009-07-01

30

Applications of CR-39 for the estimation of biological effects of heavy ion irradiation to DNA and living cells  

Energy Technology Data Exchange (ETDEWEB)

We present two applications of CR-39 to estimate biological effects of heavy ion irradiation. The accurate measurement of fluence of ions using CR-39 is indispensable to calculate the action cross sections for biological effects. Ions with 6 MeV/n at the Medium Energy Beam Course, HIMAC (NIRS) were extracted to the air, and degraded with the air. DNA and living cells were irradiated by ions with various specific energies at several air columns along with the Bragg curve. DNA strand breaks and cell killing were measured and the results were converted to the action cross sections using the fluence measured with CR-39 at the irradiation positions. Another example of the application of CR-39 is to identify whether the ions with a specific energy pass through the cell or stop within the cell. (author)

2001-10-01

31

Biological Surface-Active Substance  

International Science & Technology Center (ISTC)

Development of biological preparation with surfactant activity

32

The Prognostic Significance of p53, Bcl-2, Cytokeratin 20 and Ki-67 in Primary Superficial Papillary Transitional Bladder Carcinoma  

International Nuclear Information System (INIS)

Identification of factors that determine individual patient risk for recurrence and progression in superficial papillary carcinoma of the bladder is a subject of extensive research as it would be a major outcome in patient management. It has been well recognized that traditional prognostic markers as tumor grade and stage are not accurate enough in predicting biological behavior. A large number of markers have been investigated as potential prognostic factors and relatively few can help in predicting outcome. Material and Methods: Forty-nine cases undergoing complete transurethral resection for primary superficial papillary transitional cell carcinoma were subjected to clinicopathologic evaluation as well as immunohistochemical staining for p53, bcl-2, cytokeratin 20 and Ki-67. The CAS-200 image analyzer was used to estimate the Ki-67 labeling index. Results: Recurrence was observed in 19 cases (38.8%) and progression in 7 cases (14.3%) with a ...

2003-03-01

33

Possible processes of abiogenic synthesis of biologically important compounds on surface of small bodies in the Solar System  

International Nuclear Information System (INIS)

A mixture of aminoacids was irradiated by a scattered proton beam, its energy varying from 4 to 6.6 MeV, by doses up to 5 x 10"1"1 proton/cm"2 for studying the potentiality of abiogenic synthesis of biologically important compounds in space. It was ascertained that increase in the radiation dose and reduction of proton energy involve increase in effectiveness both of destruction of the initial aminoacid (tryptophan, tyrosine, glycine) and synthesis of the relevant dipeptide. Essential influence of mineral substrate on abiogenic synthesis of natural nucleotides under the action of diverse energy sources was pointed out

2004-04-01

34

ELECTRON MICROSCOPE PREPARATIONS OF RADIOACTIVELY LABELED AEROSOLS  

Science.gov (United States)

A method is described to smear extremely thin layers of nuclear emulsion on labeled electron microscope preparations and to measure the thicknesses of these layers, Without further separation, preparation and emulsion can be observed after exposure and development in an electron microscope. The source of the tracks formed in the emulsion can be exactly identified and the size and structure determined. This method finds applications in dust research and also in the analysis of medical and biological sections. Further information can be obtained about properties of different emulsions. (auth)

1963-04-01

35

Using long term biological monitoring data to evaluate the recovery of disturbed systems  

International Nuclear Information System (INIS)

Biological monitoring has been conducted in industrially impacted streams near US Department of Energy facilities in Tennessee and Kentucky for almost ten years. A comprehensive Biological Monitoring and Abatement Program, which was developed to meet National Pollutant Discharge Elimination System permit requirements, includes tasks on (1 ) toxicity testing; (2) bioaccumulation in aquatic and terrestrial biota; (3) bioindicators of fish health; and (4) fish, macroinvertebrate, and periphyton community surveys. These studies have been used successfully to characterize spatial trends and demonstrate temporal recovery resulting from remedial actions and pollution abatement activities, identify contaminant sources, and provide data for conducting ecological risk assessments. The program uses multiple lines of evidence to evaluate stream recovery and illustrates the importance of using an integrated approach when determining ...

1995-11-05

36

Biology and outbreaks of Microdiprion pallipes (Hymenoptera; Diprionidae) in Sweden  

Energy Technology Data Exchange (ETDEWEB)

During outbreaks, Microdiprion pallipes (Fall.) is the most destructive of the pine sawflies in Sweden. Its distribution includes most provinces, but damaging outbreaks have until recently occurred only in two inland areas in northern Sweden. These areas are characterised by high elevation, a harsh climate, and slow tree growth. The four recorded outbreak periods showed a 10 year periodicity. Outside these areas, a lesser outbreak occurred in 1988 to 1990, on the east coast (province of Uppland). Outbreak patterns, life history variation, and mortality factors were studied. Factors that may explain the distribution of outbreaks and the population patterns were identified.Experimental and observational evidence on the potential of various factors to influence fecundity, dispersal, and survival was evaluated. In the outbreak areas, there were few major population factors. Parasitism by Rhorus substitutor (Thunb.) was the largest cause of larval ...

1994-01-01

37

Interconnected project 'Development and testing of a biological monitoring for effects of polycyclic aromatic hydrocarbons on man'  

International Nuclear Information System (INIS)

The research project had the aim to develop a standard for measuring individual, inner stresses from polycyclic aromatic hydrocarbons (PAHs) at work. The employed method was by characterizing PAHs and metabolites of PAHs to be identified in urine with a view to developing a biological monitoring of professionally exposured persons. Using a number of PAHs relevant to work, the following questions were studied in cell culture systems and different animal-experimental models: Which metabolites are formed from the PAHs used in cell culture systems and the different animal-experimental models, and what are their ratios in percent? What percentage of a PAH is excreted by experimental animals in their urine and faeces on the first, second, and third day following different forms of application? What is the scale of the individual range of variation of PAH mass excretion? Are these results transferable to man? (orig.).

1992-01-01

38

Safety review of conceptual fusion power plants  

Science.gov (United States)

The potential public safety impacts from accidents in conceptual fusion power plants were investigated. Fusion was found to have some potential for accidents, as does any energy generating system. Functions of fusion power plants were identified that possess sufficient potential for an accidental release of toxic materials to the environment. An assessment was made of the impact of the potential accidents and recommendations are included for R and D that will allow incorporation of safety concerns in fusion power plant design. This work was based on a review of information available in conceptual design documents of fusion reactor systems.

1976-11-01

39

Safety review of conceptual fusion power plants  

International Nuclear Information System (INIS)

The potential public safety impacts from accidents in conceptual fusion power plants were investigated. Fusion was found to have some potential for accidents, as does any energy generating system. Functions of fusion power plants were identified that possess sufficient potential for an accidental release of toxic materials to the environment. An assessment was made of the impact of the potential accidents and recommendations are included for R and D that will allow incorporation of safety concerns in fusion power plant design. This work was based on a review of information available in conceptual design documents of fusion reactor systems.

40

Antimicrobial potential of Glycyrrhiza glabra roots  

British Library Electronic Table of Contents (United Kingdom)

The present study was aimed to investigate antimicrobial potential of Glycyrrhiza glabra roots. Antimycobacterial activity of Glycyrrhiza glabra was found at 500mg/mL concentration. Bioactivity guided phytochemical analysis identified glabridin as potentially active against both Mycobacterium tuberculosis H37Ra and H37Rv strains at 29.16mg/mL concentration. It exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria. Our results indicate potential use of licorice as antitubercular agent through systemic experiments and sophisticated anti-TB assay.

2008-01-01

41

Silencing of Hepatic Fatty Acid Transporter Protein 5 in Vivo Reverses Diet-induced Non-alcoholic Fatty Liver Disease and Improves Hyperglycemia*S?  

UK PubMed Central (United Kingdom)

Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes. To investigate the biological outcome and therapeutic potential of hepatic fatty acid uptake inhibition,...Full Text Available

2008-08-08

42

Using microarrays to identify positional candidate genes for QTL: the case study of ACTH response in pigs  

UK PubMed Central (United Kingdom)

BackgroundMicroarray studies can supplement QTL studies by suggesting potential candidate genes in the QTL regions, which by themselves are too large to provide a limited selection...Full Text Available

43

Laboratory Evaluation of Base Materials for Neutralization of the Contaminated Aquifer at the F-Area Seepage Basins  

Energy Technology Data Exchange (ETDEWEB)

Laboratory studies were performed to support field-testing of base injection into the F-Area Seepage Basins groundwater. The general purpose of these experiments is to provide information to guide the test of base injection and to identify potential adverse effects.

2001-09-11

44

Coal to liquids technology (Overview - Research)  

Wastenet

... After completing a review into direct coal liquefaction research carried out in Australia and internationally, CSIRO has identified potential new science and technology developments that may improve the cost and viability of CTL in a greenhouse gas-constrained environment. We are conducting research to: determine the optimum ...

45

Brain transcriptomic analysis in paper wasps identifies genes associated with behaviour across social insect lineages  

UK PubMed Central (United Kingdom)

Comparative sociogenomics has the potential to provide important insights into how social behaviour evolved. We examined brain gene expression profiles of the primitively eusocial wasp Polistes...Full Text Available

2010-07-22

46

Biobank resources for future patient care: developments, principles and concepts  

UK PubMed Central (United Kingdom)

The aim of the overview is to give a perspective of global biobank development is given in a view of positioning biobanking as a key resource for healthcare to identify new potential markers that can...Full Text Available

47

Bacterial Competition for Human Nasal Cavity Colonization: Role of Staphylococcal agr Alleles  

UK PubMed Central (United Kingdom)

We examined the bacterial aerobic nasal flora of 216 healthy volunteers to identify potential competitive interactions among different species, with special emphasis on the influence of staphylococcal...Full Text Available

2003-01-01

48

A Novel Mouse Model of Red Blood Cell Storage and Post-Transfusion in Vivo Survival  

UK PubMed Central (United Kingdom)

BackgroundStorage of RBCs is necessary for an adequate blood supply. However, reports have identified potential negative sequelae of transfusing stored RBCs. An animal...Full Text Available

2009-08-01

49

Technical area status report for chemical/physical treatment. Volume 2, Appendices  

Energy Technology Data Exchange (ETDEWEB)

These Appendices describe various technologies that may be applicable to the Mixed Waste Treatment Plant (MWTP) Chemical/Physical Treatment System (CPTS). These technologies were identified by the CPTS Technical Support Group (TSG) as potentially applicable to a variety of separation, volume reduction, and decontamination requirements. The purpose was to identify all available and developing technologies, and their characteristics, for subsequent evaluation for specific requirements identified for the CPTS. However, the technologies described herein are not necessarily all inclusive, nor are they necessarily all applicable.

1993-08-01

50

Spark decomposition of SF/sub 6/  

Energy Technology Data Exchange (ETDEWEB)

Gas-insulated systems employing SF/sub 6/ are utilized in a variety of applications in power delivery systems. Because electric arcs, sparks or corona can decompose SF/sub 6/ into by-products having chemical properties different from SF/sub 6/, environmental concerns arise regarding inadvertent human exposures to electrically-decomposed SF/sub 6/. Biological assays in our laboratory using mammalian cell culture systems have revealed that SF/sub 6/, spark-decomposed under specific experimental conditions, can produce cell death. Chemical analysis of spark-decomposed SF/sub 6/ has identified the major decomposition pathways and by-products. Biological testing of individual by-products or by-product mixtures has indicated that these major decomposition products may not account for the majority of the cell killing effects seen in our assays. Further experiments have suggested that S/sub 2/F/sub 10/ may be produced and ...

1989-07-01

51

Interconnected project 'Development and testing of a biological monitoring for effects of polycyclic aromatic hydrocarbons on man'. Final report. Verbundprojekt Entwicklung und Erprobung biologischer Ueberwachungsmethoden (Biological Monitoring) bei der Einwirkung von polycyklischen aromatischen Kohlenwasserstoffen auf den Menschen. Abschlussbericht  

Energy Technology Data Exchange (ETDEWEB)

The research project had the aim to develop a standard for measuring individual, inner stresses from polycyclic aromatic hydrocarbons (PAHs) at work. The employed method was by characterizing PAHs and metabolites of PAHs to be identified in urine with a view to developing a biological monitoring of professionally exposured persons. Using a number of PAHs relevant to work, the following questions were studied in cell culture systems and different animal-experimental models: Which metabolites are formed from the PAHs used in cell culture systems and the different animal-experimental models, and what are their ratios in percent What percentage of a PAH is excreted by experimental animals in their urine and faeces on the first, second, and third day following different forms of application What is the scale of the individual range of variation of PAH mass excretion Are these results transferable to man (orig.).

1992-01-01

52

Biological conversion of synthesis gas. Limiting conditions/scale-up  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this research is to develop a technically and economically feasible process for biologically producing H(sub 2) from synthesis gas while, at the same time, removing harmful sulfur gas compounds. Six major tasks are being studied: 1. Culture development, where the best cultures are selected and conditions optimized for simultaneous hydrogen production and sulfur gas removal; 2. Mass transfer and kinetic studies in which equations necessary for process design are developed; 3. Bioreactor design studies, where the cultures chosen in Task 1 are utilized in continuous reaction vessels to demonstrate process feasibility and define operating conditions; 4. Evaluation of biological synthetic gas conversion under limiting conditions in preparation for industrial demonstration studies; 5. Process scale-up where laboratory data are scaled to larger-size units in preparation for process demonstration in a pilot-scale unit; and 6. Economic ...

1993-09-01

54

An immunochemical approach to the study of DNA damage and repair. Technical progress report, May 1, 1989--April 30, 1992  

Energy Technology Data Exchange (ETDEWEB)

The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on ...

1992-05-01

55

An immunochemical approach to the study of DNA damage and repair  

Energy Technology Data Exchange (ETDEWEB)

The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on ...

1992-05-01

56

The hippo pathway in biological control and cancer development  

British Library Electronic Table of Contents (United Kingdom)

Abstract The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis. Deregulation of the Hippo pathway is linked to cancer development. Its first core kinase Warts was identified in Drosophila more than 15 years ago, but it gained much attention when other core components of the pathway were identified 8 years later. Major discoveries of the pathway were made during past several years. The core kinase components Hippo, Salvador, Warts, and Mats in the fly and Mst1/2, WW45, Lats1/2, and Mob1 in mammals phosphorylate and inactivate downstream transcriptional co-activators Yorkie in the fly, Yes-associated protein (YAP) and transcriptional co-activator with ...

2011-01-01

57

Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder  

British Library Electronic Table of Contents (United Kingdom)

Background Identifying susceptibility genes for endophenotypes by studying analogous behaviors across species is an important strategy for understanding the pathophysiology underlying psychiatric disorders. This approach provides novel biological pathways plus validated animal models critical for selective drug development. One such endophenotype is avoidance behavior. Methods In the present study, novel automated registration methods for longitudinal behavioral assessment in home cages are used to screen a panel of recently generated mouse chromosome substitution strains that are very powerful in quantitative trait loci (QTL) detection of complex traits. In this way, we identified chromosomes regulating avoidance behavior (increased sheltering preference) independent of motor activity lev...

2009-01-01

58

Isolation and biological activity of lipids from licorice (Glycyrrhiza glabra) roots  

British Library Electronic Table of Contents (United Kingdom)

Hexane extract of licorice (Glycyrrhiza glabra L.) roots was obtained and investigated. Hydrocarbons, sterol ethers, triacylglycerides, free fatty acids, and free sterols were identified. The extract contains 70% neutral and 30% polar lipids. It is established that the lipid fraction of licorice roots is more effective than the analogous fraction of rosehip oil in stimulating the reparative regeneration of skin. In addition, this fraction also exhibits pronounced antiinflammatory and antiulcer effects, while being virtually nontoxic. Based on these results, the lipid fraction of licorice roots can be recommended as a parent substance for creating effective preparations in various medicinal forms.

2007-01-01

59

Side effects of grain protectants on biological control agents: How Hyptis plant extracts affect parasitism and larval development of Dinarmus basalis  

British Library Electronic Table of Contents (United Kingdom)

Dinarmus basalis Rondani (Hymenoptera: Pteromalidae), an ectoparasitoid of bruchid pests of stored cowpeas (Vigna unguiculata), is a potential biological control agent. We investigated whether grain protectants from Hyptis spicigera and H. suaveolens (Lamiaceae) disturb parasitism and post-embryonic growth of the parasitoid. When cowpeas containing bruchid larvae were treated before being placed in the presence of D. basalis females, the rate of parasitism decreased on average up to 24% and 47% in the presence of, respectively, leaf dry powder and essential oils from both plant species. The estimated larval mortality was higher on treated (9.55 to 28.6%) than on non-treated parasitized hosts (2.8%), depending on the plant species and the plant extract tested. Additional larval mortality wa...

2011-01-01

60

Photoacoustic imaging using an ultrasonic Fresnel zone plate transducer  

International Nuclear Information System (INIS)

A photoacoustic (PA) imaging system based on an ultrasonic Fresnel zone plate (FZP) transducer is developed for the purpose of imaging biological tissue. This FZP transducer has a two-zone negative zone plate piezoelectric material pattern, and an optical fibre is integrated with the transducer on the symmetric axis of the zone plates to deliver laser pulses to the sample. The focal characteristic of the FZP transducer is analysed by theoretical prediction and experimental measurement, and the measured results are in good agreement with the predicted results. The limited-field back-projection deconvolution algorithm combined with the coherence-factor weighting technique is used to reconstruct the optical absorption distribution. The experiments were performed with phantoms and the blood vessels of chicken embryo chorioallantoic membrane. The results demonstrate that PA imaging using the FZP transducer has the ability to image biological tissue ...

2008-05-07

61

Biological treatment of wine of distilleries  

International Nuclear Information System (INIS)

The potential of the yeast Candida tropicalis and Candida guillermondii was evaluated and an isolated partnership of microorganisms of waters of the Medellin River, conformed by two bacteria and one leavening, to degrade the content of organic matter present in wine produced by the factory of Licores and Alcoholes de Antioquia (FLA) in aerobic process with biomass production. For each one of the microorganisms in study this capacity of removal in units of chemical demand of oxygen was quantified (CDO); in addition, parameters were analyzed such as yield of the biomass in relation to the removed CDO and to total reducing sugars (TRS) consumed, time of fermentation and speed of growth different dilutions from wine. Also the possible inhibition was analyzed that the present phenolic compounds in this wine can cause in the biological process of degradation.

62

Environmental analysis of endocrine disrupting effects from hydrocarbon contaminants in the ecosystem. 1997 annual progress report  

Energy Technology Data Exchange (ETDEWEB)

'The overall objective of the basic research grant is to characterize the potential of common hydrocarbon contaminants in ecosystems to act as endocrine disruptors. The three major lines of research include (1) a biotechnology based screening system to identify potential hormone mimics and antagonists; (2) an animal screening system to identify biomarkers of endocrine effects. and (3) a literature review to identify compounds at a variety of DOE sites that need to be examined for endocrine disrupting effects. By relating results obtained from this research project to contamination problems at various DOE sites. CBR will provide data and information on endocrine disrupting contaminants to DOE for consideration in risk analyses for determining clean-up levels and priorities needed at the sites.'

1997-01-01

63

Environmental assessment of the potential effects of aquifer thermal energy storage systems on microorganisms in groundwater  

Energy Technology Data Exchange (ETDEWEB)

The primary objective of this study was to evaluate the potential environmental effects (both adverse and beneficials) of aquifer thermal energy storage (ATES) technology pertaining to microbial communities indigenous to subsurface environments (i.e., aquifers) and the propagation, movement, and potential release of pathogenic microorganisms (specifically, Legionella) within ATES systems. Seasonal storage of thermal energy in aquifers shows great promise to reduce peak demand; reduce electric utility load problems; contribute to establishing favorable economics for district heating and cooling systems; and reduce pollution from extraction, refining, and combustion of fossil fuels. However, concerns that the widespread implementation of this technology may have adverse effects on biological systems indigeneous to aquifers, as well as help to propagate and release pathogenic organisms that enter thee environments need to be ...

1988-03-01

64

Inventory of Tank Farm equipment stored or abandoned aboveground  

Energy Technology Data Exchange (ETDEWEB)

This document provides an inventory of Tank Farm equipment stored or abandoned aboveground and potentially subject to regulation. This inventory was conducted in part to ensure that Westinghouse Hanford Company (WHC) does not violate dangerous waste laws concerning storage of potentially contaminated equipment/debris that has been in contact with dangerous waste. The report identifies areas inventoried and provides photographs of equipment.

1994-10-12

65

Sources of toxicity and exposure information for identifying chemicals of high concern to children  

International Nuclear Information System (INIS)

Due to the large number of chemicals in commerce without adequate toxicity characterization data, coupled with an ineffective federal policy for chemical management in the United States, many states are grappling with the challenge to identify toxic chemicals that may pose a risk to human health and the environment. Specific populations (e.g., children, elderly) are particularly sensitive to these toxic chemicals. In 2008, the Children's Safe Product Act (CSPA) was passed in Washington State. The CSPA included specific requirements to identify High Priority Chemicals (HPCs) and Chemicals of High Concern to Children (CHCCs). To implement this legislation, a methodology was developed to identify HPCs from authoritative scientific and regulatory sources on the basis of toxicity criteria. Another set of chemicals of concern was then identified from authoritative sources, based on their ...

2010-11-01

66

Summary of research on microbiological processes. International Energy Agency Subtask D, final report  

Energy Technology Data Exchange (ETDEWEB)

Storage of thermal energy in aquifers has obvious benefits of saving energy and decreasing the consumption of fossil fuels. However, aquifer thermal energy storage (ATES), which involves groundwater aquifers as the storage medium for heat or chill, impinges on the environment. A literature review of pertinent microbiology publications (Hicks and Stewart, 1988) identified the potential for the interaction of ATES systems and microbiological processes to create a source of infectious diseases and the potential for damage to the environment. In addition, the review identified a potential for microbiological processes to develop conditions that would interfere with the operation of an ATES system. As a result of this research effort, investigators from Finland, Germany, Switzerland, and the United States have examined several ATES systems in operation and have observed that the ATES ...

1992-09-01

67

Summary of research on microbiological processes  

Energy Technology Data Exchange (ETDEWEB)

Storage of thermal energy in aquifers has obvious benefits of saving energy and decreasing the consumption of fossil fuels. However, aquifer thermal energy storage (ATES), which involves groundwater aquifers as the storage medium for heat or chill, impinges on the environment. A literature review of pertinent microbiology publications (Hicks and Stewart, 1988) identified the potential for the interaction of ATES systems and microbiological processes to create a source of infectious diseases and the potential for damage to the environment. In addition, the review identified a potential for microbiological processes to develop conditions that would interfere with the operation of an ATES system. As a result of this research effort, investigators from Finland, Germany, Switzerland, and the United States have examined several ATES systems in operation and have observed that the ATES ...

1992-09-01

68

An assessment of the building sector efficiency resource for the Town of Handlova  

Energy Technology Data Exchange (ETDEWEB)

Purpose of this assessment for this town in the Slovak Republic is to develop information on the building sector energy efficiency and improvement potential for use by town management to support decisions on providing energy services to Handlova citizens. Objectives were to characterize baseline space and water heat energy use and efficiency improvement potential in the residential and nonresidential building sectors. Intention was to identify major areas of efficiency improvement potential and cost-effectiveness. Four levels of energy and fuel prices were used. A significant efficiency resource exists in the space and water heating end uses in these building sectors; it amounts to 42% of the total building sector space and water heat energy consumption.

1995-10-01

69

Radiological concepts in radiotherapy  

International Nuclear Information System (INIS)

The atomic explosions in Hiroshima and Nagasaki made the name radiation itself become a nightmare. Notwithstanding this, radiation continued to serve the mankind specially in diagnosis of several human diseases and in the treatment of intractable malignancies. With their latest research tools biologists have now shown a significant shift in the earlier paradigm; even the concept that radiation initiates cancer appears to be no longer tenable. On the contrary, selective radiation doses inhibit growth of cancer cells and radiation in combination with many chemotherapeutic drugs, radiosensitizing chemicals and/or hyperthermia, is emerging as a new modality for cancer treatment which offers high therapeutic advantages. In addition, the deleterious effects of radiation can now be strategically counter poised by the use of many drugs and chemicals. This has been possible by the newer insights gained in the mechanism of biological effects of radiation. The fate of ...

70

The complexities of skeletal biology  

Science.gov (United States)

For a long time, the skeleton was seen as an amorphous tissue of little biological interest. But

2003-01-01

71

The analysis of biological and environmental samples for lead by photon activation  

International Nuclear Information System (INIS)

... activation analysis biological materials bremsstrahlung environment lead lead

72

Entomopathogenic Nematodes in Biological Control  

International Science & Technology Center (ISTC)

Commercial Production and Development, in Entomopathogenic Nematodes in Biological Control

73

Biology and Monitoring of Diamondback Terrapins in the Chesapeake Bay  

Science.gov (United States)

... to maintaining healthy terrapin populations in the Chesapeake. Biology and Monitoring of Diamondback Terrapins in the Chesapeake ... ...

74

Biological Research for Radiation Protection  

International Nuclear Information System (INIS)

The work scope of 'Biological Research for the Radiation Protection' had contained the research about ornithine decarboxylase and its controlling proteins, thioredoxin, peroxiredoxin, S-adenosymethionine decarboxylase, and glutamate decarboxylase 67KD effect on the cell death triggered ionizing radiation and H_2O_2(toxic agents). In this study, to elucidate the role of these proteins in the ionizing radiation (or H_2O_2)-induced apoptotic cell death, we utilized sensesed (or antisensed) cells, which overexpress (or down-regulate) RNAs associated with these proteins biosynthesis, and investigated the effects of these genes on the cytotoxicity caused by ionizing radiation and H_2O_2(or paraquat). We also investigated whether genisteine(or thiamine) may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation (may enhance the preventing effect radiation or paraquat-induced damage) because such compounds are able to potentiate the ...

75

Relationship between copper speciation and cyanobacterial distribution in harbors and other coastal environments. Final report, 1 July 1993--1 November 1998  

Energy Technology Data Exchange (ETDEWEB)

The long term goal is to determine the ecological importance of specific toxic metals (copper and zinc) in harbors, through an understanding of their chemistry and biological effects at the base of marine food chains. This work provides information on potential problems with Zn and Cu, which may help to foresee problems in the future. Anthropogenic inputs of both metals are increasing; they are derived from diverse sources and are a simple function of population growth in coastal regions.

1998-11-01

76

Lithium isotopes: differential effects in animals  

Energy Technology Data Exchange (ETDEWEB)

Differences in the biological disposition and in the effects of the stable lithium isotopes, Li-6 and Li-7, in animals were characterized. A somewhat higher toxicity was associated with WLiCl compared to XLiCl with NLiCl intermediate. All lithium treatments increased water intake and resulted in weight gain. Peak plasma concentration was slightly high for 6Li than 7LiCl suppressed action potential amplitudes during tetanic stimulation more than NaCl when added to Renger solution bathing ganglia.

1984-04-01

77

Chemical aspects of uranium behavior in soils: A review  

British Library Electronic Table of Contents (United Kingdom)

Uranium has varying degrees of oxidation (+4 and +6) and is responsive to changes in the redox potential of the environment. It is deposited at the reduction barrier with the participation of biota and at the sorption barrier under oxidative conditions. Iron (hydr)oxides are the strongest sorbents of uranium. Uranium, being an element of medium biological absorption, can accumulate (relative to thorium) in the humus horizons of some soils. The high content of uranium in uncontaminated soils is most frequently inherited from the parent rocks in the regions of positive U anomalies: in the soils developed on oil shales and in the marginal zone of bogs at the reduction barrier. The development of nuclear and coal-fired power engineering resulted in the environmental contamination with uranium....

2011-01-01

78

Case for applying subnanosecond high-intensity, electrical pulses to biological cells.  

Science.gov (United States)

In this paper, model analysis into the time-dependent transmembrane potential at the outer cell membrane is presented, for applied high-intensity electric pulses having durations in the nanosecond range or smaller. It is argued that the frequency-dependent dielectric response of cell membranes could be used to advantage for stronger bioeffects by employing shorter pulses. Our model calculations predict faster transmembrane voltages and larger electroporation densities for a given external energy with pulse durations in the subnanosecond regime. This temporal regime would be used, for example, in the electrotherapy of mixed cell ensembles having different dielectric response properties. PMID:21937300

2011-10-01

79

Spark decomposition of SF/sub 6/: Chemical and biological studies  

Energy Technology Data Exchange (ETDEWEB)

Gas-insulated systems employing SF/sub 6/ are utilized in a variety of applications in power delivery systems. Because electric arcs, sparks or corona can decompose SF/sub 6/ into byproducts having chemical properties different from SF/sub 6/, environmental concerns arise regarding inadvertent human exposures to electrically-decomposed SF/sub 6/. Biological assays in our laboratory using mammalian cell culture systems have revealed that spark-decomposed SF/sub 6/ produces cell death, and the extent of cell killing increases with increasing spark energy. Chemical analysis of spark-decomposed SF/sub 6/ has identified the major decomposition pathways and byproducts, but biological testing of individual or byproduct mixtures has indicated that these major decomposition products do not contribute, in a significant fashion, to the cell lethality seen in our assays. Further experiments have suggested that S/sub 2/F/sub 10/ may be ...

1987-01-01

80

Energy management, real estate management, and facility management; Energiemanagement in der Immobilienverwaltung  

Energy Technology Data Exchange (ETDEWEB)

The publication presents an outline of the subject of energy management and attempts to test the hypotheses that targeted knowledge management may result in new developments and potentials, and if these are at all desirable. On this basis, a knowledge management system will be developed that may effectively promote developments and potentials in the field of energy management. The tools and fundamentals of energy management are looked into, and the given situation and desired goals are identified by means of an enquiry. This is a scientific study that aims at providing empirical information on the situation and views on the subject of energy management. The analysis, which is supported by an enquiry sheet, is to provide a basis for testing the assumed hypothesis. Further, the potential acceptance and utilization potential of decisive knowledge management in the facility and real ...

2010-07-01

81

Imaging pharmacodynamics in oncology. The potential significance of 'flares'  

International Nuclear Information System (INIS)

The clinical use of "1"8F-fluorodeoxyglucose (FDG) positron emission tomography in monitoring anticancer treatment is expanding. At the same time a number of radiotracers aiming to image different aspects of tumour biology such as proliferation and apoptosis are being developed. However, the factors determining changes of radiotracer uptake parameters in response to treatment are not well understood. In many cases, cellularity may be the primary determinant of changes of FDG uptake and may confound the interpretation of metabolic changes. Early imaging assessments have in some cases showed transient increases of uptake parameters, commonly termed 'flares', which are likely to be unaffected by cellularity and directly reflect pharmacodynamics at a cellular level. In this review a number of settings where molecular imaging 'flares' have been described are discussed. Such changes may often be clinically informative and warrant careful study as ...

2010-04-01

82

Bioconversion of chicken wastes to value-added products  

Energy Technology Data Exchange (ETDEWEB)

Increasing quantities of chicken waste concerns the poultry industry because of escalating disposal costs and the potential for environmental pollution. Biological conversion of these wastes to valuable products such as methane and/or chemical feed-stocks appears to be feasible. Biomethanation of chicken waste by a sewage sludge microbial consortium produced as much as 69 mol% methane in the gas phase. Acetic and propionic acids were the major acids produced during the bioconversion. Addition of chelating agents and other micro-nutrients enhanced methane production and shifted the ratios of intermediates accumulated. Preliminary data indicate that more than 60% of the chicken waste carbon was converted and that the nitrogen-rich residue may have potential as a soil additive. (author).

1991-01-01

83

Gene expression analysis after low dose ionising radiation exposure of the developing organism  

International Nuclear Information System (INIS)

Measuring gene expression using microarrays is relevant to many areas of biology and medicine, such as follow up of developmental stages and diseases onset, and treatment study. Since there can be tens of thousands of distinct probes on an array, each micro array experiment can accomplish the equivalent number of genetic tests in parallel. Arrays have therefore dramatically accelerated many types of investigations. For example, microarrays can be used to identify stress response genes by comparing gene expression in challenged versus normal cells. In the Molecular and Cellular Biology lab (MCB), the micro array experiments are performed within the Genomic Platform, fully equipped to analyse either the behaviour of bacteria during long space flight, the effect of low dose ionising radiation on the developing organism in mice, or the human individual radiation sensitivity. For the low dose effect, two main stages of ...

2007-09-01

84

Behavioral effects of exposure to the TEMPO high-power microwave system. Interim report, January-June 1987  

Energy Technology Data Exchange (ETDEWEB)

Safety standards for exposure to radiofrequency radiation must be based upon biologic consequences of exposure to such environments. Behavioral-based measures are considered to be the most-sensitive indices of biological effects. Current safety guidelines are based upon average power density and may not be relevant to the high-peak-power, short pulse width microwave radiation produced by newly developed high peak power microwave sources. The effects of exposure to high-peak-power radiation on reflexive responding and motor function in Fischer 344/N rats were assessed by measuring startle and general activity, and disruption of on-going performance of a rotarod task, respectively. The emitter used was the TEMPO repeat pulse axially extracted vircator. Exposure to single pulses resulted in significant startle responses. Exposure to 1 pps for 10 s produced significant alterations in baseline activity and marked disruption of performance of the ...

1988-03-01

85

Sensitivity analysis: Interaction of DOE SNF and packaging materials  

International Nuclear Information System (INIS)

A sensitivity analysis was conducted to evaluate the technical issues pertaining to possible destructive interactions between spent nuclear fuels (SNFs) and the stainless steel canisters. When issues are identified through such an analysis, they provide the technical basis for answering what if questions and, if needed, for conducting additional analyses, testing, or other efforts to resolve them in order to base the licensing on solid technical grounds. The analysis reported herein systematically assessed the chemical and physical properties and the potential interactions of the materials that comprise typical US Department of Energy (DOE) SNFs and the stainless steel canisters in which they will be stored, transported, and placed in a geologic repository for final disposition. The primary focus in each step of the analysis was to identify any possible phenomena that could potentially compromise the ...

1999-06-06

86

Materials for air turbines in wave power devices. A generic study  

Energy Technology Data Exchange (ETDEWEB)

Wave energy device teams have identified three varieties of air turbine as potentially applicable to wave energy devices. These are: conventional axial turbines; Wells, or self-rectifying, axial turbines and Francis turbines. This report examines the constructional requirements of these devices with regard to mechanical, environmental and manufacturing considerations. It is concluded that the major benefit of optimum material selection will be reduced manufacturing costs rather than enhanced turbine performance. A methodology of material selection has been established and candidate materials have been listed for the major components of each turbine type. Comparative costs for alternative materials are included, from which significant, potential economies have been identified. Recommendations are made aimed at achieving optimum material usage in the proposed turbines.

1981-01-01

87

Identifying the global potential for baobab tree cultivation using ecological niche modelling  

British Library Electronic Table of Contents (United Kingdom)

The benefits provided by underutilised fruit tree species such as baobab (Adansonia digitata L.) in combating increasing malnutrition and poverty become more apparent as awareness grows regarding concerns of climate change and food security. Due to its multiple uses, its high nutritional and medicinal value, drought tolerance and relatively easy cultivation, baobab has been identified as one of the most important edible forest trees to be conserved, domesticated and valued in Africa. In order to contribute towards the cultivation of the species, suitability of sites in Africa and worldwide was evaluated for potential cultivation using species? locality data and spatial environmental data in MAXENT modelling framework. A total of 450 geo-referenced records of the baobab tree were assembled ...

2010-01-01

88

Identification of prostate cancer antigens by automated high-throughput filter immunoscreening  

British Library Electronic Table of Contents (United Kingdom)

There is a need for earlier and more accurate cancer diagnostics as well as new targets for cancer immunotherapy. To this end, it is important to identify sets of tumour antigens specific for different cancer forms. Several methods that identify potential tumour antigens in an arrayed and high-throughput format have been developed during the last years of SEREX (serological identification of antigens by recombinant expression cloning) related research. Such techniques may hold the potential to describe the complete immunogenic part of the cancer proteome, also called the cancer immunoproteome.We have developed a powerful platform for automated serological high-throughput filter screening of tumour cDNA libraries. The screening format of this method is 18,000 single cDNAs clones, which is s...

2008-01-01

89

Application of probabilistic methods to accident analysis at waste management facilities  

International Nuclear Information System (INIS)

Probabilistic risk assessment is a technique used to systematically analyze complex technical systems, such as nuclear waste management facilities, in order to identify and measure their public health, environmental, and economic risks. Probabilistic techniques have been utilized at the Waste Isolation Pilot Plant (WIPP) near Carlsbad, New Mexico, to evaluate the probability of a catastrophic waste hoist accident. A probability model was developed to represent the hoisting system, and fault trees were constructed to identify potential sequences of events that could result in a hoist accident. Quantification of the fault trees using statistics compiled by the Mine Safety and Health Administration (MSHA) indicated that the annual probability of a catastrophic hoist accident at WIPP is less than one in 60 million. This result allowed classification of a catastrophic hoist accident as ''not credible'' at WIPP per DOE ...

90

Validation of biological markers for quantitative risk assessment.  

UK PubMed Central (United Kingdom)

The evaluation of biological markers is recognized as necessary to the future of toxicology, epidemiology, and quantitative risk assessment. For biological markers to become widely accepted, their validity...Full Text Available

1991-01-01

91

How safe are the biologicals in treating asthma and rhinitis?  

UK PubMed Central (United Kingdom)

A number of biological agents are available or being investigated for the treatment of asthma and rhinitis. The safety profiles of these biologic agents, which may modify allergic and immunological...Full Text Available

92

Biosphere analyses for the safety assessment SR-Site - synthesis and summary of results  

Energy Technology Data Exchange (ETDEWEB)

This report summarises nearly 20 biosphere reports and gives a synthesis of the work performed within the SR-Site Biosphere project, i.e. the biosphere part of SR-Site. SR-Site Biosphere provides the main project with dose conversion factors (LDFs), given a unit release rate, for calculation of human doses under different release scenarios, and assesses if a potential release from the repository would have detrimental effects on the environment. The intention of this report is to give sufficient details for an overview of methods, results and major conclusions, with references to the biosphere reports where methods, data and results are presented and discussed in detail. The philosophy of the biosphere assessment was to make estimations of the radiological risk for humans and the environment as realistic as possible, based on the knowledge of present-day conditions at Forsmark and the past and expected future development of the site. This was achieved by using the ...

2010-12-15

93

Underground electric-power transmission-system environmental impact assessment  

Energy Technology Data Exchange (ETDEWEB)

The US Department of Energy, Division of Electric Energy Systems, has undertaken to identify the environmental issues and potential impacts associated with the installation of underground electric power transmission systems. This study reports the results of investigations into the advanced cable technologies being considered for future underground applications, as part of the development oriented research program of the Division of Electric Energy Systems. While the technology involves a high level of sophistication, there are relatively few impacts to the environment that are potentially significant, and of these none are inherently non-mitigable. Route planning, system design, and methods of construction and accident response can be pursued in order to minimize impacts where strict constraints are appropriate.

1982-03-01

94

Thermal-receiver designs for line-focus solar collectors  

Energy Technology Data Exchange (ETDEWEB)

Considerable potential exists for increasing the annual efficiency of line-focus collectors by reducing receiver heat losses. Five alternate receiver designs are compared with a standard design. The comparison is based on annual collector-field efficiency using optimized receiver designs. Of the receivers studied, the all-glass design and the cavity design provide the greatest increases in efficiency. Average fluid temperatures range from 200/sup 0/ to 450/sup 0/C. As a guide for further study, areas of uncertainty and potential problems are identified.

1982-02-01

95

The identification of the 1/2"+[660] proton orbitals at high spins in rare-earth nuclei  

International Nuclear Information System (INIS)

Decay sequences based on the 1/2"+[660] proton orbital have been identified in "1"7"1Ta and "1"7"7Re based on spin, parity, and large alignment. This decay sequence is observed higher in energy than predicted in cranking calculations based on modified oscillator potentials. Similarly known 1/2"-[541] decay sequences in these and other neighbouring isotopes are observed lower in energy than predicted. A reduction in the strength of the spin-orbit potential for protons is suggested as a solution to these problem. (orig.).

96

Mine-associated wetlands as avian habitat  

Energy Technology Data Exchange (ETDEWEB)

Surveys for interior wetland birds at mine-associated emergent wetlands on coal surface mines in southern Illinois detected one state threatened and two state endangered species. Breeding by least bittern (Ixobrychus exilis) and common moorhen (Gallinula chloropus) was confirmed. Regional assessment of potential wetland bird habitat south of Illinois Interstate 64 identified a total of 8,109 ha of emergent stable water wetlands; 10% were associated with mining. Mine-associated wetlands with persistent hydrology and large expanses of emergent vegetation provide habitat that could potentially compensate for loss of natural wetlands in Illinois.

1998-06-01

97

Identification of the 1/2/sup +/(660) proton orbitals at high spins in rare-earth nuclei  

Energy Technology Data Exchange (ETDEWEB)

Decay sequences based on the 1/2/sup +/(660) proton orbital have been identified in /sup 171/Ta and /sup 177/Re based on spin, parity, and large alignment. This decay sequence is observed higher in energy than predicted in cranking calculations based on modified oscillator potentials. Similarly known 1/2/sup -/(541) decay sequences in these and other neighbouring isotopes are observed lower in energy than predicted. A reduction in the strength of the spin-orbit potential for protons is suggested as a solution to these problem.

1983-12-08

98

Modeling human risk: Cell & molecular biology in context  

Energy Technology Data Exchange (ETDEWEB)

It is anticipated that early in the next century manned missions into outer space will occur, with a mission to Mars scheduled between 2015 and 2020. However, before such missions can be undertaken, a realistic estimation of the potential risks to the flight crews is required. One of the uncertainties remaining in this risk estimation is that posed by the effects of exposure to the radiation environment of outer space. Although the composition of this environment is fairly well understood, the biological effects arising from exposure to it are not. The reasons for this are three-fold: (1) A small but highly significant component of the radiation spectrum in outer space consists of highly charged, high energy (HZE) particles which are not routinely experienced on earth, and for which there are insufficient data on biological effects; (2) Most studies on the biological effects of radiation to date have ...

1997-06-01

99

SAR of Cu (II) Thiosemicarbazone Complexes as Hypoxic Imaging Agents: MM3 Analysis and Prediction of Biologic Properties  

British Library Electronic Table of Contents (United Kingdom)

Abstract Copper(II) bis(thiosemicarbazone) are very useful for blood flow and hypoxic imaging. The aim of this study was to identify structure-activity relationships (SARs) within a series of analogues with different substitution patterns in the ligands, in order to design improved hypoxia imaging agents and elucidate hypoxia selectivity mechanisms. Genetic algorithms (GAs) were used to develop specific copper metal-ligand force field parameters for the MM3 force-field calculations. These new parameters produced results in good agreement with experiment and previously reported copper metal-ligand parameters. A successful quantitative SAR (QSAR) for predicting the several classes of Cu(II)-chelating ligands was built using a training set of 21 Cu(II) complexes. The QSAR exhibited a correlat...

2010-01-01

100

Removal of natural humic acids by decolorizing actinomycetes isolated from different soils (Algeria) for application in water purification  

British Library Electronic Table of Contents (United Kingdom)

Humic acids are considered problematically in drinking water because it can react readily with chlorine to form carcinogen compounds and its biological removal is much recommended. The scanning electron microscopy morphologies and optical parameters observed for natural humic acids (NHAs) extracted from different soils at Mitidja plain (Algeria) made them different from the commercial ones. Three of the most active strains of 19 actinomycetes were isolated and selected from surface soils at this plain. These strains were identified based on cultural characteristics and chemotaxonomic analysis and classified in the genus Streptomyces. Growth of these strains was assured on a poor liquid medium containing NHAs as carbon and nitrogen sources and degradation occur only in the presence of gluco...

2010-01-01

101

Phipps Bend Nuclear Plant construction effects monitoring report, October 19, 1978-October 18, 1979  

International Nuclear Information System (INIS)

The aquatic monitoring program consists of onsite monitoring of surface runoff, monitoring of point source discharges identified in the NPDES permit, and limited instream biological monitoring. The program is tied to a feedback mechanism for implementing corrective action before significant adverse impacts occur in the Holston River. This report evaluates the aquatic monitoring program for the second year (October 19, 1978 through October 18, 1979) of construction as required by the NPDES permit, Part III, Section I. Included in this report are data from peripheral runoff monitoring, selected heavy rainfall sampling, ground water monitoring, instream aquatic macroinvertebrate monitoring, and aquatic macrophyte monitoring.

102

Mechanisms of obesity-induced male infertility  

British Library Electronic Table of Contents (United Kingdom)

Male infertility, characterized by hypogonadism, decreased semen quality or ejaculatory dysfunction, accounts for approximately 20% of infertility cases. Obesity and metabolic dysfunction have been identified, among other causal factors, to contribute to male infertility. In the context of the Western world's `obesity epidemic', this article discusses three main biological mechanisms linking obesity to impaired male reproductive function: hypogonadism, testicular heat stress/hypoxia-induced apoptosis and endocrine disruption by `obesogens'. Among these, obesity-induced hypogonadism is undoubtedly the most clinically significant and is easily assessed. Rapidly expanding areas of research in this area include leptin modulation of kisspeptins and hypothalamic-pituitary-testicular hormone path...

2010-01-01

103

Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas  

British Library Electronic Table of Contents (United Kingdom)

Spindle cell sarcomas consist of tumors with different biological features, of which distant metastasis is the most ominous sign for a poor prognosis. However, metastasis is difficult to predict on the basis of current histopathological analyses. We have identified actin filament-associated protein 1-like 1 (AFAP1L1) as a candidate for a metastasis-predicting marker from the gene expression profiles of 65 spindle cell sarcomas. A multivariate analysis determined that AFAP1L1 was an independent factor for predicting the occurrence of distant metastasis (P=0.0001), which was further confirmed in another set of 41 tumors by a quantitative mRNA expression analysis. Immunohistochemical staining using paraffin-embedded tumor tissues revealed that the metastasis-free rate was significantly better...

2011-01-01

104

Hydrothermal faunal assemblages and habitat characterisation at the Eiffel Tower edifice (Lucky Strike, Mid-Atlantic Ridge)  

British Library Electronic Table of Contents (United Kingdom)

Abstract The Eiffel Tower edifice is situated in the Lucky Strike hydrothermal vent field at a mean depth of 1690-m on the Mid-Atlantic Ridge (MAR). At this 11-m-high hydrothermal structure, different faunal assemblages, varying in visibly dominant species (mussels and shrimp), in mussel size and in density of mussel coverage, were sampled biologically and chemically. Temperature and sulphide (-S) were measured on the different types of mussel-based assemblages and on a shrimp-dominated assemblage. Temperature was used as a proxy for calculating total concentrations of CH4. Based on the physico-chemical measurements, two microhabitats were identified, corresponding to (i) a more variable habitat featuring the greatest fluctuations in environmental variables and (ii) a second, more stable, ...

2011-01-01

105

GFAP in health and disease  

British Library Electronic Table of Contents (United Kingdom)

Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development. Major recent developments in astrocyte biology and the discovery of novel intermediate filament functions enticed the interest in the function of GFAP. The discovery of various GFAP splice variants gave an additional boost to explore this protein in more detail.The structural role of GFAP in astrocytes has been widely accepted for a long time, but over the years, GFAP has been shown to be involved in astrocyte functions, which are important during regeneration, synaptic plasticity and reactive gliosis. Moreover, different subpopulations of astrocytes have been identified, which are likely to have distinc...

2011-01-01

106

Experimental optimization of a real time fed-batch fermentation process using Markov decision process.  

Science.gov (United States)

This article describes a methodology that implements a Markov decision process (MDP) optimization technique in a real time fed-batch experiment. Biological systems can be better modeled under the stochastic framework and MDP is shown to be a suitable technique for their optimization. A nonlinear input/output model is used to calculate the probability transitions. All elements of the MDP are identified according to physical parameters. Finally, this study compares the results obtained when optimizing ethanol production using the infinite horizon problem, with total expected discount policy, to previous experimental results aimed at optimizing ethanol production using a recombinant Escherichia coli fed-batch cultivation. (c) 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 55: 317-327, 1997. PMID:18636490

1997-07-20

107

Continuing the search for a fundamental law of mortality  

Energy Technology Data Exchange (ETDEWEB)

For 170 years, scientists have attempted to explain why consistent temporal patterns of death are observed among individuals within populations. Historical efforts to identify a {open_quotes}law of mortality{close_quotes} from these patterns ended in 1935 when it was declared that such a law did not exist. These empirical tests for a law of mortality were constructed using mortality curves based on all causes of death. We predicted that patterns of mortality consistent with the historical concept of a law would be revealed if mortality curves for species were constructed using only senescent causes of death. Using data on senescent mortality for laboratory animals and humans, we demonstrate that patterns of mortality overlap when compared on a biologically comparable time scale. These results are consistent with the existence of a law of mortality following sexual maturity as asserted by Benjamin Gompertz and Raymond Pearl. The societal, ...

1997-08-01

108

Continuing the search for a fundamental law of mortality  

Energy Technology Data Exchange (ETDEWEB)

for 170 years, scientists have attempted to explain why consistent temporal patterns of death are observed among individuals within populations. Historical efforts to identify a `law of mortality` from these patterns ended in 1935 when it was declared that such a law did not exist. These empirical tests for a law of mortality were constructed using mortality curves based on all causes of death. We predicted patterns of mortality consistent with the historical concept of a law would be revealed if mortality curves for species were constructed using only senescent causes of death. Using data on senescent mortality for laboratory animals and humans, we demonstrate patterns of mortality overlap when compared on a biologically comparable time scale. The results are consistent with the existence of a law of mortality following sexual maturity. The societal, medical, and research implications of such a law are discussed.

1996-03-01

109

Assessment of the supramolecular structures presents into biological samples by SAXS technique;Avaliacao das estrutras supramoleculares presentes em amostras biologicas atraves da tecnica de SAXS  

Energy Technology Data Exchange (ETDEWEB)

In this work was made an assessment of the supramolecular structures presents into human breast tissue normal and pathological samples, as well as into two types of animals samples (tendon chicken and pork fat) using the small angle x-ray scattering (SAXS) technique. The scattering profiles of the samples were determined at the momentum transfer range O.150nm{sup -1}<=5:q(=4pi.sin({theta}/2)/{lambda})<=8.500nm{sup -1}. In this range, it was possible identify structures corresponding to collagen fibrils (glandular tissue) and to triacylglycerides (adipose tissue) from the correlation between the information extracted from the human breast tissues scattering profiles and those extracted from animals samples. (author)

2009-07-01

114

University of Central Lancashire - Facilities  

Wastenet

...specialised laboratories for pharmaceutics, tissue culture and molecular biology Excellent Laboratory Facilities Tissue Culture Facilities Molecular Biology Laboratory ...

115

Spectroscopy, colorimetry, and biological chemistry in the nineteenth century.  

UK PubMed Central (United Kingdom)

The development of colorimetry and spectroscopy in the nineteenth century is described. An account is given of the application of their techniques to biological chemistry during that period.

1981-03-01

116

Biology of the Rio Grande Border Region: A Bibliography  

Science.gov (United States)

BIOLOGY OF THE RIO GRANDE BORDER REGION: A BIBLIOGRAPHY Information and Technology Report USGS/BRD/ITR--1997- .....

117

Remote measurement of methane in coal mines: a review  

Energy Technology Data Exchange (ETDEWEB)

The authors identify a need for a device which can remotely measure methane in coal mines. Similar techniques which have been used to measure atmospheric pollutants are discussed. These techniques include adsorption, Raman scattering and fluorescence. While differential adsorption and Raman scattering techniques have potential there are a number of problems to be resolved before they could be applied effectively. It is felt that an area which may provide suitable technology sometime in the future is in the field of laser sources. 6 refs., 4 tabs.

1987-02-01

118

Overview of cleaner production as a result of clean technology research in Vietnam  

Energy Technology Data Exchange (ETDEWEB)

Vietnam is beginning its industrialization process, and it currently lacks the capital necessary for expensive pollution control and treatment systems. Pollution strategies are critical for the country. This study evaluates the present status of industry and the pollution problems associated with industrial development in Vietnam. The purpose of the study is to identify sectors that may have potential for promoting cleaner production practices. 4 refs.

1996-12-31

119

Long-term chemical carcinogenesis experiments for identifying potential human cancer hazards: collective database of the National Cancer Institute and National Toxicology Program (1976-1991).  

UK PubMed Central (United Kingdom)

The carcinogenicity database used for this paper originated in the late 1960s by the National Cancer Institute (NCI) and since 1978 has been continued and made more comprehensive by the National Toxicology...Full Text Available

1991-12-01

120

Implications of biodiversity of short rotation coppice  

Environmental Research Database

DescriptionFossil fuels have a detrimental effect on the environment. They lead to the increase in atmospheric carbon dioxide which has been documented over the last 150 years. In contrast, some sources of renewable energy are near carbon neutral. Renewable energy produced from biomass constitutes such a type of energy and so has many potential advantages. The Energy White Paper (DTI et al., 2003) identifies bioenergy as an important means of meeting the Government's energy and environment objectives, in [continued...

2009-01-31

121

Genome-Wide Association Study SNPs in the Human Genome Diversity Project Populations: Does Selection Affect Unlinked SNPs with Shared Trait Associations?  

UK PubMed Central (United Kingdom)

Genome-wide association studies (GWAS) have identified more than 2,000 trait-SNP associations, and the number continues to increase. GWAS have focused on traits with potential consequences for human...Full Text Available

2011-01-01

122

Genetic and Structural Insights into the Dissemination Potential of the Extremely Broad-Spectrum Class A ?-Lactamase KPC-2 Identified in an Escherichia coli Strain and an Enterobacter cloacae Strain Isolated from the Same Patient in France?  

UK PubMed Central (United Kingdom)

Two clinical strains of Escherichia coli (2138) and Enterobacter cloacae (7506) isolated from the same patient in France and showing resistance to extended-spectrum...Full Text Available

2008-10-01

123

Generic design framework pile foundations (fixed steel structures)  

Energy Technology Data Exchange (ETDEWEB)

To assist in attaining the HSE's objective of providing perspective and focus for Safety Case Assessment, a generic model of the structural design process for the foundations of pile supported fixed steel structures has been developed. Interfaces between the foundation design team and other stakeholders have been identified and assessments made of both the magnitude and the potential significance of the uncertainties associated with key elements of the design process. (author)

2001-07-01

124

Effect of spatial variation on salinity tolerance of macroinvertebrates in Eastern Australia and implications for ecosystem protection trigger values  

International Nuclear Information System (INIS)

Salinisation of freshwater has been identified as a serious environmental issue in Australia and around the world. Protective concentrations (trigger values) for salinity can be used to manage salinity impacts, though require locally relevant salinity tolerance information. 72-h acute salinity tolerance values were determined for 102 macroinvertebrates collected from 11 locations in four biologically distinct freshwater bio-regions in Northeast Australia and compared with sensitivities observed in Southeast Australia. The salinity tolerance of individual taxa was consistent across Northeast Australia and between Northeast and Southeast Australia. However, two distinct communities were identified in Northeast Australia using distributions of the acute tolerance values and a calculated index of salinity sensitivity. Salinity trigger values should therefore be representative of local or regionally relevant communities and may ...

2008-02-01

125

Systems Biology Approach in Chlamydomonas Reveals Connections between Copper Nutrition and Multiple Metabolic Steps[C][W][OA  

Science.gov (United States)

In this work, we query the Chlamydomonas reinhardtii copper regulon at a whole-genome level. Our RNA-Seq data simulation and analysis pipeline validated a 2-fold cutoff and 10 RPKM (reads per kilobase of mappable length per million mapped reads) (~1 mRNA per cell) to reveal 63 CRR1 targets plus another 86 copper-responsive genes. Proteomic and immunoblot analyses captured 25% of the corresponding proteins, whose abundance was also dependent on copper nutrition, validating transcriptional regulation as a major control mechanism for copper signaling in Chlamydomonas. The impact of copper deficiency on the expression of several O2-dependent enzymes included steps in lipid modification pathways. Quantitative lipid profiles indicated increased polyunsaturation of fatty acids on thylakoid membrane digalactosyldiglycerides, indicating a global impact of copper deficiency on the photosynthetic apparatus. Discovery of a putative plastid copper chaperone and a membrane protease in the thylakoid ...

2011-04-01

126

Matrix-assisted laser desorption fourier transform mass spectrometry for biological compounds  

Science.gov (United States)

The recent development of matrix-assisted UV laser desorption (LD) mass spectrometry has made possible the ionization and detection of extremely large molecules (with molecular weights exceeding 100,000 Daltons). This technique has generated enormous interest in the biological community for the direct examination of large peptides and oligonucleotides. Although this matrix-assisted ionization method has been developed and used almost exclusively with time-of-flight (TOF) mass spectrometers, research is currently in progress to demonstrate this technique with trapped ion mass spectrometers, such as Fourier transform ion cyclotron resonance mass spectrometry (FTMS). The potential capabilities of FTMS for wide mass range, high resolution measurement, and ion trapping experiments suggest that this instrumental technique should be useful for the detailed structural characterization of large ions generated by the matrix-assisted technique. We have ...

1990-01-01

127

Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders.  

Science.gov (United States)

Chinese herbs have been and still are widely used as important remedies in Oriental medicine. Over the recent years, a variety of biologically active constituents have been isolated from these sources and confirmed to have multifunctional activity in experimental studies. Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. It is accompanied by other related polyphenols, including magnolol, with which it shares certain biological properties. Recently, honokiol and magnolol have been found to have anti-oxidative, anti-inflammatory, anti-tumor, and anti-microbial properties in preclinical models, without appreciable toxicity. These findings have increased interest in bringing honokiol and magnolol to the clinic as novel therapeutic agents in dermatology. In this review, the findings concerning the major mechanisms of action of honokiol and magnolol are described. Knowledge of the multiple activities of honokiol and magnolol ...

2010-09-16

128

Bomb "1"4C and human radiation burden  

International Nuclear Information System (INIS)

Following the publication (Stenhouse and Baxter, Nature; 267:828 (1977)) of the levels of bomb "1"4C and the residence times of carbon in the human body, excess radiation burdens from this radioisotope are evaluated under the assumption that no radiation dose, however small, can be regarded as entirely harmless biologically. The estimated annual absorbed dose attributable to "1"4C both natural and man-made for 1953-1973 and similar predicted figures for 1975-2025 are shown graphically. The cumulated doses to gonads (over 30 yr) and to bone marrow and bone-lining cells (over 60 yr) and also estimates of the biological damage to reproductive cells from "1"4C #beta#-irradiation (30 yr accumulated dose) are presented. It is concluded from both genetic and somatic considerations, that the potential human radiation burden due to artificially produced "1"4C calculated using the assumptions stated is certainly significant and, ...

129

Prediction of the naturalisation potential and weediness risk of transgenic cotton in Australia  

British Library Electronic Table of Contents (United Kingdom)

Climex climate-matching and inferential-modelling was used to examine the naturalisation potential of genetically modified and non-transgenic Upland Cotton (Gossypium hirsutum variety hirsutum) in Australia north of latitude 22degreeS. The Climate-Match (CM) function was used to identify locations in north-east Australia where climate matches (CM Index>0.7) the experimental sites of Eastick [Eastick, R., 2002. The Potential Weediness of Transgenic Cotton in Northern Australia. Northern Territory Department of Business, Industry and Resource Development Technical Bulletin No. 305 (Internet resource: http://cotton.pi.csiro.au/Assets/PDFFiles/TB3051.pdf)] in north-west Australia. Most of Australia north of 22degreeS had climate matching one or more of the sites of Eastick (2002), locations wh...

2007-01-01

130

An old tool with potential new uses: return on investment  

British Library Electronic Table of Contents (United Kingdom)

Purpose - The purpose of this paper is to examine potential new uses of return on investment (ROI) in alternative methods for library assessment and valuation. Design/methodology/approach - Uses examples of recent uses of ROI by libraries to identify potential new applications of ROI in library assessment and valuation. Findings - ROI investment has historically been used by libraries for the assessment of past performance of library organizations in a reactive/defensive nature or for assessing the value of customer services. ROI has not been widely used as a proactive assessment tool, to introspectively assess administrative or other internal services, or as an offensive assessment and valuation tool, especially for intangible performance assessment and valuation. Originality/value - New ...

2007-01-01

131

Accelerated aging corrosion tests for buried metal structures  

Energy Technology Data Exchange (ETDEWEB)

It is necessary to identify those measurable soil parameters which dictate the severity of the corrosion problem for coated irons and steels. When this is done, meaningful accelerated aging tests can be designed to validate the reduced corrosion rate for the planned coating. The following discussion introduces the important concepts and measurement parameters in the (a) design of accelerated aging tests, and (b) evaluation of the planned installation site for corrosion potential. Certain combinations of soil oxidation reduction potential (ORP) or electric potential (Eh), acidity (pH), fertilizer, water table, and soil hydraulic conductivity can result in severe corrosion of buried steel/iron vessels. If there are power lines nearby, additional loss of vessel material to the soil will occur. These factors are discussed.

1996-10-01

132

Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia  

British Library Electronic Table of Contents (United Kingdom)

Combination agents comprising two different pharmacophores with the same biological target have the potential to show additive or synergistic activity. Bis(thiosemicarbazonato)copper(II) complexes (e.g. 64Cu-ATSM) and nitroimidazoles (e.g. 18F-MISO) are classes of tracer used for the delineation of tumor hypoxia by positron emission tomography (PET). Three nitroimidazole-bis(thiosemicarbazonato)copper(II) conjugates were produced in order to investigate their potential as combination hypoxia imaging agents. Two were derived from the known bifunctional bis(thiosemicarbazone) H2ATSM/A and the third from the new precursor diacetyl-2-(4-N-methyl-3-thiosemicarbazone)-3-(4-N-ethylamino-3-thiosem icarbazone) - H2ATSM/en. Oxygen-dependent uptake studies were performed using the 64Cu radiolabelled ...

2010-01-01

133

Toxicological benchmarks for screening contaminants of potential concern for effects on freshwater biota  

International Nuclear Information System (INIS)

An important early step in the assessment of ecological risks at contaminated sites is the screening of chemicals detected on the site to identify those that constitute a potential risk. Part of this screening process is the comparison of measured ambient concentrations to concentrations that are believed to be nonhazardous, termed benchmarks. This article discusses 13 methods by which benchmarks may be derived for aquatic biota and presents benchmarks for 105 chemicals. It then compares them with respect to their sensitivity, availability, magnitude relative to background concentrations, and conceptual bases. This compilation is limited to chemicals that have been detected on the US Department of Energy's Oak Ridge Reservation (ORR) and to benchmarks derived from studies of toxic effects on freshwater organisms. The list of chemicals includes 45 metals and 56 industrial organic chemicals but only four pesticides. Although some individual ...

134

Hydrocarbon potential of offshore South Florida basin  

Energy Technology Data Exchange (ETDEWEB)

The results of an extensive, detailed geologic and geophysical evaluation of the offshore South Florida basin show this area to have considerable hydrocarbon exploration potential. Geophysical mapping on six key horizons identified numerous structural closures at Dollar Bay through Bone Island mapping levels. Geologic evaluation indicated at least four viable potential reservoir horizons, including the Sunniland formation - the main producing unit onshore in what is called the Sunniland trend. Mature, organic rich carbonate source rocks are found in several stratigraphic intervals throughout the basin, and extensively developed seals consisting of micritic limestones and anhydrites are also common in the stratigraphic section. All the critical factors for hydrocarbon accumulation - source, reservoir, trap, and seal - appear to be present in the offshore Pulley ridge area of the South Florida basin. Using high-resolution ...

1986-05-01

135

X-ray Phase Imaging Microscopy using a Fresnel Zone Plate and a Transmission Grating  

International Nuclear Information System (INIS)

We report on a hard X-ray phase imaging microscopy (a phase-difference microscopy) that consists of an objective and a transmission grating. The simple optical system provides a quantitative phase image, and does not need a wave field mostly coherent on the objective. Our method has a spatial resolution almost same as that of the absorption contrast microscope image obtained by removing the grating. We demonstrate how our approach provides a phase image from experimentally obtained images. Our approach is attractive for easily appending a quantitative phase-sensitive mode to normal X-ray microscopes, and has potentially broad applications in biology and material sciences.

2010-06-23

136

Translational bioinformatics and healthcare informatics: computational and ethical challenges.  

Science.gov (United States)

Exponentially growing biological and bioinformatics data sets present a challenge and an opportunity for researchers to contribute to the understanding of the genetic basis of phenotypes. Due to breakthroughs in microarray technology, it is possible to simultaneously monitor the expressions of thousands of genes, and it is imperative that researchers have access to the clinical data to understand the genetics and proteomics of the diseased tissue. This technology could be a landmark in personalized medicine, which will provide storage for clinical and genetic data in electronic health records (EHRs). In this paper, we explore the computational and ethical challenges that emanate from the intersection of bioinformatics and healthcare informatics research. We describe the current situation of the EHR and its capabilities to store clinical and genetic data and then discuss the Genetic Information Nondiscrimination Act. Finally, we posit that the synergy obtained from ...

2009-09-16

137

Transcranial magnetic stimulation in adolescent depression  

British Library Electronic Table of Contents (United Kingdom)

Objective: There are few safe and effective biological treatments for major depression in adolescents. We aimed to report the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for adolescents with this condition. Methods: The first two subjects in a double-blind, sham-controlled trial of rTMS that is evaluating the efficacy and safety of rTMS in depressed adolescents are described. Clinical response was assessed at baseline and at the end of each week. The following scales were used: Montgomery-Asberg Depression Rating Scale, Clinical Global Impression-Severity Scale, Beck Depression Inventory and Centre for Epidemiological Studies - Depression - Child Scale. A battery of cognitive tests was also used at several intervals to measure potential change in neuropsycholo...

2006-01-01

138

Techno-economic comparison of a biological hydrogen process and a 2nd generation ethanol process using barley straw as feedstock  

British Library Electronic Table of Contents (United Kingdom)

A process combining dark fermentation and photofermentation for production of hydrogen is interesting due to its potential of producing hydrogen at a high yields. In this study, the hydrogen process is compared to a 2nd generation ethanol process with respect to cost and with the aim of increasing our understanding of the pros and cons and giving a clear picture of the present status of the two processes. The hydrogen production cost was found to be about 20 times higher than the ethanol production cost, 421.7&z.euro;/GJ compared to 19.5&z.euro;/GJ. The main drawbacks of the hydrogen process are its low productivity, low energy efficiency, and the high cost of buffer and base required to control the pH.

2011-01-01

139

Simple isolation of polonium-210 from silver  

Energy Technology Data Exchange (ETDEWEB)

Over the last several years considerable concern has been expressed regarding the potential detrimental effects of radon and radon progeny on our health. The complex nature of the radon decay scheme, which involves the emission of a variety of radiations including several [alpha] particles, [beta] particles, and [gamma]-rays, does not lend itself to clear delineation of the biological effects of the [alpha] particles alone. Polonium-210, the terminal radionuclide of the radon decay series, is useful for this purpose because it has a relatively long shelf-life ([tau][sub 1/2] = 138 d), and it only emits a single 5.3 MeV [alpha] particle in its decay to stable [sup 206]Pb. Accordingly, it has been used extensively in radiobiological studies with incorporated radionuclides. The radionuclide [sup 210]Po is produced in a reactor from [sup 209]Bi. (Author).

1994-05-01

140

Palladium polypyridyl complexes: synthesis, characterization, DNA interaction and biological activity on Leishmania (L.) mexicana  

Energy Technology Data Exchange (ETDEWEB)

This paper describes the search for new potential chemotherapeutic agents based on transition metal complexes with planar ligands. In this study, palladium polypyridyl complexes were synthesized and characterized by elemental analysis, NMR, UV-VIS and IR spectroscopies. The interaction of the complexes with DNA was also investigated by spectroscopic methods. All metal-to-ligand charge transfer (MLCT) bands of the palladium polypyridyl complexes exhibited hypochromism and red shift in the presence of DNA. The binding constant and viscosity data suggested that the complexes [PdCl{sub 2}(phen)] and [PdCl{sub 2}(phendiamine)] interact with DNA by electrostatic forces. Additionally, these complexes induced an important leishmanistatic effect on L. (L.) mexicana promastigotes at the final concentration of 10 {mu}mol L{sup -1} in 48 h. (author)

2008-07-01

141

Opportunities for Russian Nuclear Weapons Institute developing computer-aided design programs for pharmaceutical drug discovery. Final report  

Energy Technology Data Exchange (ETDEWEB)

The goal of this study is to determine whether physicists at the Russian Nuclear Weapons Institute can profitably service the need for computer aided drug design (CADD) programs. The Russian physicists` primary competitive advantage is their ability to write particularly efficient code able to work with limited computing power; a history of working with very large, complex modeling systems; an extensive knowledge of physics and mathematics, and price competitiveness. Their primary competitive disadvantage is their lack of biology, and cultural and geographic issues. The first phase of the study focused on defining the competitive landscape, primarily through interviews with and literature searches on the key providers of CADD software. The second phase focused on users of CADD technology to determine deficiencies in the current product offerings, to understand what product they most desired, and to define the potential demand for such a ...

1996-09-23

142

New [{sup 99m}Tc]-cytectrene amine compounds as specific brain imaging agents  

Energy Technology Data Exchange (ETDEWEB)

Lipophilic tertiary amines attached to cylcopentadienyl technetium-99m tricarbonyl (cytectrene) have been prepared with high radiochemical yield and purity. Biodistribution studies in mice showed that [{sup 99m}Tc]-cytectrenes, containing in their structure an N-methylpiperidine, were accumulated in the brain up to 2.8% of injected dose with high brain-to-blood ratios at 15 min p.i. They therefore indicate some potential as brain imaging agents. It has to be pointed out that the N-methylpiperidine ester showed similar biological behaviour as the keto derivatives. This indicates that the conversion to polar metabolite(s) via hydrolysis of the ester group - as described for [{sup 99m}Tc]-ECD -is not essential for brain retention. (Author).

1995-02-01

143

New ["9"9"mTc]-cytectrene amine compounds as specific brain imaging agents  

International Nuclear Information System (INIS)

Lipophilic tertiary amines attached to cylcopentadienyl technetium-99m tricarbonyl (cytectrene) have been prepared with high radiochemical yield and purity. Biodistribution studies in mice showed that ["9"9"mTc]-cytectrenes, containing in their structure an N-methylpiperidine, were accumulated in the brain up to 2.8% of injected dose with high brain-to-blood ratios at 15 min p.i. They therefore indicate some potential as brain imaging agents. It has to be pointed out that the N-methylpiperidine ester showed similar biological behaviour as the keto derivatives. This indicates that the conversion to polar metabolite(s) via hydrolysis of the ester group - as described for ["9"9"mTc]-ECD -is not essential for brain retention. (Author).

144

Ligand Tuning in Asymmetric Hydrovinylation of 1,3-Dienes. A Stereoselective Route to either Steroid-C20 (S) or -C20 (R) Derivatives  

Science.gov (United States)

1,3-Dienes derived from steroidal D-ring C17-ketones undergo Ni(II)-catalyzed hydrovinylation to give 1,2- or 1,4-addition of ethylene. Using finely tuned phosphoramidite ligands it is possible to synthesize either the C20 (R)- or the C20 (S)-derivatives without mutual contamination. The proportion of the 1,4-adduct, which is also formed stereoselectively, can be minimized by optimizing the reaction conditions. Since the two alkenes in the resultant dienes have differing steric demands for many potential reactions, and are ideally juxtaposed for further D-ring functionalization, these intermediates could be useful for the preparation of biologically important compounds such as vitamin D analogs and various antitumor steroidal glycosides.

2008-06-21

145

Interactions of -lactoglobulin with serotonin and arachidonyl serotonin  

British Library Electronic Table of Contents (United Kingdom)

Abstract -Lactoglobulin (-LG) is a lipocalin, which is the major whey protein of cow's milk and the milk of other mammals. However, it is absent from human milk. The biological function of -LG is not clear, but its potential role in carrying fatty acids through the digestive tract has been suggested. -LG has been found in complexes with lipids such as butyric and oleic acids and has a high affinity for a wide variety of compounds. Serotonin (5-hydroxytryptamine, 5-HT), an important compound found in animals and plants, has various functions, including the regulation of mood, appetite, sleep, muscle contraction, and some cognitive functions such as memory and learning. In this study, the interaction of serotonin and one of its derivatives, arachidonyl serotonin (AA-5HT), with -LG was invest...

2011-01-01

146

Copper-64 Radiopharmaceuticals for PET Imaging of Cancer: Advances in Preclinical and Clinical Research  

British Library Electronic Table of Contents (United Kingdom)

Summation Copper-64 (T1/2?=?12.7 hours; ?+, 0.653?MeV [17.8 %]; ??, 0.579?MeV [38.4 %]) has decay characteristics that allow for positron emission tomography (PET) imaging and targeted radiotherapy of cancer. The well-established coordination chemistry of copper allows for its reaction with a wide variety of chelator systems that can potentially be linked to peptides and other biologically relevant small molecules, antibodies, proteins, and nanoparticles. The 12.7-hours half-life of 64Cu provides the flexibility to image both smaller molecules and larger, slower clearing proteins and nanoparticles. In a practical sense, the radionuclide or the 64Cu-radiopharmaceuticals can be easily shipped for PET imaging studies at sites remote to the production facility. Due to the versatility of 64Cu, ...

2009-01-01

147

Assessment of GABARAP self-association by its diffusion properties  

Energy Technology Data Exchange (ETDEWEB)

Gamma-aminobutyric acid type A receptor-associated protein (GABARAP) belongs to a family of small ubiquitin-like adaptor proteins implicated in intracellular vesicle trafficking and autophagy. We have used diffusion-ordered nuclear magnetic resonance spectroscopy to study the temperature and concentration dependence of the diffusion properties of GABARAP. Our data suggest the presence of distinct conformational states and provide support for self-association of GABARAP molecules. Assuming a monomer-dimer equilibrium, a temperature-dependent dissociation constant could be derived. Based on a temperature series of {sup 1}H{sup 15}N heteronuclear single quantum coherence nuclear magnetic resonance spectra, we propose residues potentially involved in GABARAP self-interaction. The possible biological significance of these observations is discussed with respect to alternative scenarios of oligomerization.

2010-09-15

148

A logarithmic time complexity algorithm for pattern searching using product-sum property  

British Library Electronic Table of Contents (United Kingdom)

Product-sum property states that an ordered pair (s"n,p"n) is unique for any ordered set a"1,a"2,...,a"n where a"i,n@?N, and s"n and p"n are the sum and product of the elements of the set, respectively. This fact has been exploited to develop an O(log(M)) time complexity algorithm for pattern searching in a large dataset, where M is the number of records in the dataset. Two potential applications (from databases and computational biology) of this property have been demonstrated to show the effectiveness and working of the proposed algorithm. The space complexity of the algorithm rises to the quadratic order.

2011-01-01

149

Study of a loop heat pipe using neutron radiography.  

Science.gov (United States)

An explanation is given of what a loop heat pipe (LHP) is, and how it works. It is then shown that neutron imaging (both real time neutron radioscopy and single exposure neutron radiography) is an effective experimental tool for the study of LHPs. Specifically, neutron imaging has helped to identify and correct a cooling water distribution problem in the condenser, and has enabled visualization of two-phase flow (liquid and vapor) in various components of the LHP. In addition, partial wick dry-out, a phenomenon of great importance in the effective operation of LHPs, is potentially identifiable with neutron imaging. It is anticipated that neutron radioscopy and radiography will greatly contribute to our understanding of LHP operation, and will lead to improvement of LHP modeling and design. PMID:15246420

2004-10-01

150

Study of a loop heat pipe using neutron radiography  

Energy Technology Data Exchange (ETDEWEB)

An explanation is given of what a loop heat pipe (LHP) is, and how it works. It is then shown that neutron imaging (both real time neutron radioscopy and single exposure neutron radiography) is an effective experimental tool for the study of LHPs. Specifically, neutron imaging has helped to identify and correct a cooling water distribution problem in the condenser, and has enabled visualization of two-phase flow (liquid and vapor) in various components of the LHP. In addition, partial wick dry-out, a phenomenon of great importance in the effective operation of LHPs, is potentially identifiable with neutron imaging. It is anticipated that neutron radioscopy and radiography will greatly contribute to our understanding of LHP operation, and will lead to improvement of LHP modeling and design.

2004-10-01

151

Remedial investigation/feasibility study for the David Witherspoon, Inc., 901 Site, Knoxville, Tennessee: Volume 1  

Energy Technology Data Exchange (ETDEWEB)

This remedial investigation (RI)/feasibility study (FS) supports the selection of remedial actions for the David Witherspoon, Inc. 901 Maryville Pike Site in Knoxville, Tennessee. Operations at the site, used as a recycling center, have resulted in past, present, and potential future releases of hazardous substances in to the environment. This Site is a Tennessee Superfund site. A phased approach was planned to (1) gather existing data from previous investigations managed by the Tenn. Dept. of Environment and Conservation; (2) perform a preliminary RI, including risk assessments, and an FS with existing data to identify areas where remedial action may be necessary; (3) gather additional field data to adequately define the nature and extent of risk-based contaminants that present identifiable threats to human and/or ecological receptors; and (4) develop remedial action alternatives to reduce risks to acceptable levels.

1996-10-01

152

Explosives detector  

Energy Technology Data Exchange (ETDEWEB)

An apparatus for non-invasively inspecting an object, such as an item of luggage, for explosives material is described. It comprises a multi-channel thermal neutron inspection system having a plurality of neutron irradiation chambers. Simultaneous operation of several channels increases the maximum system throughput several times. Each chamber has a lithium neutron source which is stimulated to neutron production by a proton beam. Beam switching magnets are energised by pulsing to divert a common proton beam to each source in turn. The initial beam is generated by a radio frequency quadrupole accelerator. The advantages of this system are very low residual source activity and controllable neutron production thereby minimising safety hazards. The irradiation chamber may contain several different gamma ray detectors to identify the elements present in explosives material. In addition, a neutron radiography imaging means may be employed to ...

1991-10-02

153

Application of chaos theory in identification of two-phase flow patterns and transitions in a small, horizontal, rectangular channel  

Energy Technology Data Exchange (ETDEWEB)

Various measurement tools that are used in chaos theory were applied to analyze two-phase pressure signals with the objective of identifying and interpreting flow pattern transitions for two-phase flows in a small, horizontal rectangular channel. These measurement tools included power spectral density function, autocorrelation function, pseudo-phase-plane trajectory, Lyapunov exponent,s and fractal dimensions. It was demonstrated that the randomlike pressure fluctuations characteristic of two-phase flow in small rectangular channels are chaotic, and governed by a high-order deterministic system. The correlation dimension is potentially a new approach for identifying certain two-phase flow patterns and transitions.

1996-06-01

154

An analysis of tanker-based floating production systems for small offshore fields  

Energy Technology Data Exchange (ETDEWEB)

A historical review of floating production storage and offloading (FPSO) systems for marginal fields is presented. The areas in which such systems are operating, ranges of model tests, and current applicability of mooring systems are reviewed to present capabilities of these concepts. Limitations are reviewed to assess the applicability of these concepts to similar sites. Consideration of processing operations on floating vessels are identified. Particularly, the effects of vessel motion on the processing equipment, gas disposal, and crude offloading are addressed. It will be shown that operations are becoming well understood and routine. Future problem areas and solutions under development are identified. Specific examples are cited and design refinements are noted. While various floating production systems have been in operation for only a few years, their potential for solving the problems of producing small offshore ...

1982-08-01

155

Activation of a multisensory, multifunctional nucleus in the zebrafish midbrain during diverse locomotor behaviors  

British Library Electronic Table of Contents (United Kingdom)

Action potentials from the brain control the activity of spinal neural networks to produce, by as yet unknown mechanisms, a variety of motor behaviors. Particularly lacking are details on how identified descending neurons integrate diverse sensory inputs to generate specific locomotor patterns. We have examined the operations of the principal neurons in an intriguing midbrain nucleus, the nucleus of the medial longitudinal fasciculus (nMLF), in the larval zebrafish. The nMLF is the most rostral grouping of neurons that projects from the brain well into the spinal cord of teleost fishes, yet there is little direct physiological data available regarding its function. We report here that a distinct set of large, individually-identifiable neurons in nMLF (the MeL and MeM neurons) are activated...

2010-01-01

156

A single-institution review of 157 patients presenting with benign and malignant tumors of the ampulla of Vater: Management and outcomes  

British Library Electronic Table of Contents (United Kingdom)

BackgroundAlthough benign ampullary tumors are removed endoscopically, due to their potential to progress to malignant disease, the favored treatment for adenocarcinoma is pancreaticoduodenectomy. We reviewed our institutions experience in order to identify which patients were at highest risk of disease progression following surgical resection, as well as evaluate whether localized T1 tumors are best treated by pancreaticoduodenectomy. MethodsWe retrospectively reviewed 157 patients who presented with an ampullary mass, from 2001 to 2010, and identified 51 with benign adenoma and 106 with adenocarcinoma. ResultsPatients with malignant tumors most often presented with larger tumors and jaundice, which alone was predictive of survival (OR = 67). Forty-five percent of patients with pathologic...

2011-01-01

157

Bioenergy from agro-industrial residues in the East African region. Summary report  

Energy Technology Data Exchange (ETDEWEB)

Tanzania has recently developed a comprehensive environmental policy which has put high priority on several specific environmental issues. One of the issues is the quality of waste water. A special priority is given to the pollution from the sisal industry. The East-African agro-industries generate very large quantities of organic residues from production and processing of different crops. These residues form a major contribution to the pollution of air, soil and waterways, but, at the same time they constitute a large potential for production of bioenergy through anaerobic digestion as well as potential substrate for other biological fermentation processes. Generally, these residues are regarded as having no or very little value and the different disposal methods are mainly a matter of getting rid of the waste. The generation of residues are very often concentrated on few large units, which makes the exploitation of these ...

1998-05-01

158

Review of the occupational hygiene implications of the manufacture and use of nanoparticles  

Environmental Research Database

SummaryNanoparticles are increasingly being used in industry. Their potential to cause adverse health effects is due to their very small particles size (less than 100nm). A review is to be carried out to explore a) the use/release of nanoparticles in industry, b) current practices to control exposure and c) the potential levels of workplace exposure. The report will contain a discussion of what is current best practice to control exposure to nanoparticles. It will also indicate where the gaps in kn [continued...]ObjectivesA written report that draws upon disparate sources of available information and uses competent occupational hygiene expertise to form expert opinion on the implications. Key measures will the demonstration reasoned arguments supported by data from both current deliberate manufacturing of nanoparticles and incident nanoparticle production. The report will include all viable occupational exposure routes.Description1. ...

2004-01-29

159

A framework for assessing relative risks associated with multiple stressors in Port Valdez, Alaska  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this assessment is to develop a versatile process that will provide a mechanism for evaluating both present and future risks to this environment. Much of the regulatory and environmental interest in the port has centered around a Ballast Water Treatment facility that treats and discharges up to 30 mgd of oily ballast water brought in by crude oil tankers. However, six point discharges and other potential sources of pollution exist in the area. The authors have delineated eleven subareas in the port in order to identify the potential anthropogenic stressors, as well as the receptors that could be exposed to these stressors. Potential effects were then characterized for each exposure. Each component is ranked and integrated, resulting in a relative risk estimate in each subarea. Both the discernible risks, based on available data, and the data gaps are presented. Uncertainty is expressed as ...

1995-12-31

160

Synthesis characterization and biological evaluation of a novel mixed ligand "9"9"mTc complex as potential brain imaging agent  

International Nuclear Information System (INIS)

One approach in the design of neutral oxotechnetium complexes is based on the simultaneous substitution of a tridentate dianionic ligand and a monodentate monoanionic coligand on a [Tc(V)O]"+"3 precursor. Following this ''mixed ligand'' concept, a novel "9"9"mTc complex with N,N-bis(2-mercaptoethyl)-N'N'-diethylethylenediamine as ligand and 1-octanethiol as coligand is prepared and evaluated as potential brain radiopharmaceutical. Preparation of the complex at tracer level was accomplished by using "9"9"mTc-glucoheptonate as precursor. The substitution was optimized and a coligand/ligand ratio of 5 was selected. Under this conditions the labeling yield was over 80% and a major product (with radiochemical purity > 80%) was isolated by HPLC methods and used for biological evaluation. Chemical characterization at carrier level was developed using the corresponding rhenium complex as structural model. The Re complex was also prepared by ...

1998-08-01

161

Waste heat recovery systems in the sugar industry: An Indian perspective  

Energy Technology Data Exchange (ETDEWEB)

This article identifies the key role of the sugar industry in the rural development of developing countries. The Indian sugar industry, already second largest among the country`s processing industries, shows even greater potential, according to the Plan Documents (shown in a table). The potential of waste heat in sugar processing plants, which produce white crystal sugar using the double sulphitation clarification process, is estimated at 5757.9 KJ/kg of sugar. Efficient waste heat recovery (WHR) systems could help arrest the trend of increasing production costs. This would help the sugar industry not only in India, but in many other countries as well. The innovative methods suggested and discussed briefly in this article include dehydration of prepared cane, bagasse drying, and juice heating using waste heat. These methods can reduce the cost of energy in sugar production by at least 10% and improve efficiency and ...

1996-04-01

162

Synergies and conflicts in multimedia pollution control related to utility compliance with Title IV of the Clean Air Act Amendments of 1990  

Energy Technology Data Exchange (ETDEWEB)

Most analyses of the alternative strategies used by utilities to comply with Title IV requirements have focused on factors directly related to controlling sulfur dioxide (SO{sub 2}) emissions. However, utilities must meet a number of additional environmental requirements at the same tune they comply with the acid rain program. To illuminate the potential synergies and conflicts that might exist between the other regulatory mandates and the acid rain program, a thorough examination of all the various programs and their interrelationships must be conducted. This paper reviews the environmental mandates that utilities will have to plan to meet in the next decade concurrently with the acid rain program, and it analyzes the interactions among the various programs to identify potential synergies and conflicts.

1993-11-01

163

Rocky Mountain Arsenal, Basin F liquid storage tank spill, draft risk assessment  

Energy Technology Data Exchange (ETDEWEB)

The scope of this RA is limited to the evaluation of potential human health risks associated with a failure event of a tank containing Basin F liquid. Section 1.0 contains an introduction to the health risk assessment. Section 2.0 describes the site history, location, and land use. Section 3.0 provides a brief description of exposure pathways and potention receptors. Section 4.0 describes the sources of data used and identifies chemicals of concern. Section 5.0 discusses the toxicity of concern. Section 6.0 explains the methods used for calculation of carcinogenic risks and the noncarcinogenic hazard indexes. Section 7.0 describes uncertainties inherent in the current methodology used to determine potential human health risks. Section 8.0 presents a summary of results and conclusions. Section 9.0 includes the references cited.

1993-04-01

164

Hot Cell Facility (HCF) Safety Analysis Report  

Energy Technology Data Exchange (ETDEWEB)

This Safety Analysis Report (SAR) is prepared in compliance with the requirements of DOE Order 5480.23, Nuclear Safety Analysis Reports, and has been written to the format and content guide of DOE-STD-3009-94 Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Safety Analysis Reports. The Hot Cell Facility is a Hazard Category 2 nonreactor nuclear facility, and is operated by Sandia National Laboratories for the Department of Energy. This SAR provides a description of the HCF and its operations, an assessment of the hazards and potential accidents which may occur in the facility. The potential consequences and likelihood of these accidents are analyzed and described. Using the process and criteria described in DOE-STD-3009-94, safety-related structures, systems and components are identified, and the important safety functions of each SSC are described. Additionally, information which describes the safety ...

2000-11-01

165

Histone deacetylase inhibitors and transforming growth factor-b induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells  

British Library Electronic Table of Contents (United Kingdom)

Histone deacetylase (HDAC) inhibitors have been actively exploited as potential anticancer agents. To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. Detailed analyses indicated that HDAC inhibitors activated the 15-PGDH promoter-luciferase reporter construct in transfected A549 cells. A representative HDAC inhibitor, scriptaid, and its negative structural analog control, nullscript, were further evaluated at the chromatin level. Scriptaid but not nullscript induced a signific...

2006-01-01

166

Energy conservation potential in Taiwanese textile industry  

International Nuclear Information System (INIS)

Since Taiwan lacks sufficient self-produced energy, increasing energy efficiency and energy savings are essential aspects of Taiwan's energy policy. This work summarizes the energy savings implemented by 303 firms in Taiwan's textile industry from the on-line Energy Declaration System in 2008. It was found that the total implemented energy savings amounted to 46,074 ton of oil equivalent (TOE). The energy saving was equivalent to 94,614 MWh of electricity, 23,686 kl of fuel oil and 4887 ton of fuel coal. It represented a potential reduction of 143,669 ton in carbon dioxide emissions, equivalent to the annual carbon dioxide absorption capacity of a 3848 ha plantation forest. This study summarizes energy-saving measures for energy users and identifies the areas for making energy saving to provide an energy efficiency baseline.

2010-11-01

167

Dual-fuel natural gas/diesel engines: Technology, performance, and emissions. Topical report, February 1993-November 1994  

Energy Technology Data Exchange (ETDEWEB)

An investigation of current dual-fuel natural gas/diesel engine design, performance, and emissions was conducted. The most pressing technological problems associated with dual-fuel engine use were identified along with potential solutions. It was concluded that dual-fuel engines can achieve low NOx and particulate emissions while retaining fuel-efficiency and BMEP levels comparable to those of diesel engines. The investigation also examined the potential economic impact of dual-fuel engines in diesel-electric locomotives, marine vessels, farm equipment, construction, mining, and industrial equipment, and stand-alone electricity generation systems. Recommendations for further additional funding to support research, development, and demonstration in these applications were then presented.

1994-11-01

168

Assessing the environmental impacts of resource recovery facilities  

Energy Technology Data Exchange (ETDEWEB)

Technologies and practices that recover energy and materials from municipal solid waste present a technically and economically viable alternative to sanitary landfills and other solid waste disposal methods. However, community planners considering resource recovery should be aware of the potential environmental impacts of proposed projects. To assess these impacts, a planner should: identify the most significant types of impacts; establish boundaries beyond which impacts are not significant; characterize the environment as it would exist without the proposed project over the project's lifetime; predict the magnitude, and the distribution over time and space, of potential impacts; and relate the magnitude of predicted impacts to a scale of significance that will allow environmental values to be considered in decision-making. 24 references, 1 table.

1980-03-01

169

Assessing Ground Water Development Potential Using Landsat Imagery  

British Library Electronic Table of Contents (United Kingdom)

Seven villages in southeastern Kenya surround Mt. Kasigau and depend on the mountain's cloud forest for their water supply. Five of these villages have regularly experienced water shortages, and all village water supplies were contaminated with Escherichia coli bacteria. There is a need to economically find new sources of fresh ground water. Remote sensing offers a relatively quick and cost-effective way of identifying areas with high potential for ground water development. This study used spectral properties of features on Landsat remote sensing imagery to map linear features, soil types, surface moisture, and vegetation. Linear features represented geologic or geomorphologic features indicating either shallow ground water or areas of increased subsurface hydraulic conductivity. Regarding...

2010-01-01

170

Joint Thesaurus. Part I (A-L) + Part II (M-Z)  

International Nuclear Information System (INIS)

This is the 1st revision of the INIS/ETDE Joint Thesaurus. It contains 20 953 valid descriptors and 8 600 forbidden terms. It was last updated in December 2003. The Joint Thesaurus contains the controlled terminology for indexing all information within the subject scope of both INIS (International Nuclear Information System) and ETDE (Energy Technology Data Exchange) information systems. The terminology is intended for use in subject description for input or retrieval of information in those systems. The thesaurus is a terminological control device used in translating from the natural language of documents, indexers or users into a more constrained system language It is also a controlled and dynamic vocabulary of semantically and generically related terms which covers a specific domain of knowledge. The domain of knowledge covered by this Thesaurus includes physics (in particular, plasma physics, atomic and molecular physics, and especially nuclear and high-energy physics), chemistry, ...

1998-05-01

171

Gene expression profiles deciphering rice phenotypic variation between Nipponbare (Japonica) and 93-11 (Indica) during oxidative stress.  

Science.gov (United States)

Rice is a very important food staple that feeds more than half the world's population. Two major Asian cultivated rice (Oryza sativa L.) subspecies, japonica and indica, show significant phenotypic variation in their stress responses. However, the molecular mechanisms underlying this phenotypic variation are still largely unknown. A common link among different stresses is that they produce an oxidative burst and result in an increase of reactive oxygen species (ROS). In this study, methyl viologen (MV) as a ROS agent was applied to investigate the rice oxidative stress response. We observed that 93-11 (indica) seedlings exhibited leaf senescence with severe lesions under MV treatment compared to Nipponbare (japonica). Whole-genome microarray experiments were conducted, and 1,062 probe sets were identified with gene expression level polymorphisms between the two rice cultivars in addition to differential expression under MV treatment, which were assigned as Core ...

2010-01-08

172

Selection of reference soils for chemicals testing in the European Community  

International Nuclear Information System (INIS)

Based on an multivariate statistical evaluation of binary and metric data relating to the soil cover of the European Community five regionally representative reference soils (EURO-Soils) have been identified for chemicals testing in the EC. The soil material sampled at representative localities in Italy, Greece, Great Britain, France and Germany was treated and prepared according to OECD Test Guideline 106 and analysed in detail. The homogenised specimens were subject to an EC-wide ring test to evaluate the feasibility of the modified guideline and to validate the physical-chemical amenability of the reference soils for sorption tests. The results proved the validity of the soils selected for assessing the potential behaviour of new chemicals in soil on the basis of a comparative evaluation of the individual test results obtained. In the light of this parametric assessment potential test soils were subsequently ...

173

Natural fracture characterization using passive seismic illumination  

Energy Technology Data Exchange (ETDEWEB)

The presence of natural fractures in reservoir rock can significantly enhance gas production, especially in tight gas formations. Any general knowledge of the existence, location, orientation, spatial density, and connectivity of natural fractures, as well as general reservoir structure, that can be obtained prior to active seismic acquisition and drilling can be exploited to identify key areas for subsequent higher resolution active seismic imaging. Current practices for estimating fracture properties before the acquisition of surface seismic data are usually based on the assumed geology and tectonics of the region, and empirical or fracture mechanics-based relationships between stratigraphic curvature and fracturing. The objective of this research is to investigate the potential of multicomponent surface sensor arrays, and passive seismic sources in the form of local earthquakes to identify and characterize ...

2003-01-08

174

Identification of environmental RD D needs  

Energy Technology Data Exchange (ETDEWEB)

The objective of this project was to identify needs for environmental research development and demonstration projects that have the potential to improve the performance of oil and gas exploration, drilling, and production technologies for maximum recovery of domestic petroleum resources under optimal environmental and economic conditions. To achieve this objective several areas of work were addressed. The first task was to compile as much related data as possible. This was achieved by literature searches of a number of petroleum-related data bases. After acquiring sufficient background on environmental and economical areas that should be expanded, experts who are knowledgeable in these areas were contacted to further define specific issues. More than 33 identified areas were submitted to an in-house panel at NIPER to assure that the final environmental research demonstration and development needs that were selected to be ...

1991-09-01

175

Hazard analysis for 300 Area N Reactor Fuel Fabrication and Storage Facilty  

Energy Technology Data Exchange (ETDEWEB)

This hazard analysis (HA) has been prepared for the 300 Area N Reactor Fuel Fabrication and Storage Facility (Facility), in compliance with the requirements of Westinghouse Hanford Company (Westinghouse Hanford) controlled manual WHC-CM-4-46, Nonreactor Facility Safety Analysis Manual, and to the direction of WHC-IP-0690, Safety Analysis and Regulation Desk Instructions, (WHC 1992). An HA identifies potentially hazardous conditions in a facility and the associated potential accident scenarios. Unlike the Facility hazard classification documented in WHC-SD-NR-HC-004, Hazard Classification for 300 Area N Reactor Fuel Fabrication and Storage Facility, (Huang 1993), which is based on unmitigated consequences, credit is taken in an HA for administrative controls or engineered safety features planned or in place. The HA is the foundation for the accident analysis. The significant event scenarios identified by ...

1994-01-25

176

Development of advanced residential cooktop burner with low NO/sub x/ emissions. Annual report Feb 82-Jan 83  

Science.gov (United States)

This report describes the results of work conducted during February 1982 - January 1983. A literature search was initiated to identify the state-of-the-art of NOx (NO + NO/sub 2/) reduction technologies, including NOx measurement methodologies, air infiltration and ventilation trends, the impact of NOx (NO/sub 2/) emissions on health, and air quality standards. As a result of the literature search NOx (NO/sub 2/) reduction goals were established for the project and technologies to achieve these goals identified. This report also covers the development of a prototype burner which examined flue gas recirculation, burner designs, secondary air baffling and flame inserts as potential technologies to reduce NOx (NO/sub 2/). Because of their potential for NOx (NO/sub 2/) reduction shown by initial experiments, an in-depth analysis of ring insert configurations was conducted. These results, along with other ...

1983-02-28

177

Avoidable thermodynamic inefficiencies and costs in an externally fired combined cycle power plant  

Energy Technology Data Exchange (ETDEWEB)

The real thermodynamic inefficiencies in a thermal system are related to exergy destruction and exergy loss. An exergy analysis identifies the system components with the highest exergy destruction and the processes that cause them. However, only a part of the exergy destruction in a component can be avoided. A minimum exergy destruction rate for each system component is imposed by physical, technological, and economic constraints. The difference between the total and the unavoidable exergy destruction rate represents the avoidable exergy destruction rate, which provides a realistic measure of the potential for improving the thermodynamic efficiency of a component. The calculation of avoidable cost rates associated with both exergy destruction and capital investment is described in the paper and is applied to the exergoeconomic evaluation of an externally fired combined cycle power plant. For each plant component, avoidable and unavoidable ...

2006-08-15

178

Analysis of options for coal combustion waste management in the Pacific Basin  

Energy Technology Data Exchange (ETDEWEB)

Many Pacific Basin countries rely on oil for electricity production. Alternative fuel sources such as coal, which is available in the Pacific Basin, can help mitigate adverse impacts of sudden price increases or supply disruptions. Coal combustion produces solid and potentially hazardous wastes of concern to environmental regulators and utility managers. This paper identifies issues associated with managing coal combustion wastes in the Pacific Basin, using the state of Hawaii as a case study. Hawaii is typical of many Pacific Basin locations in that it depends on oil, has limited sites, for waste management operations, and is subject to domestic and international waste management regulations. The paper discusses coal-fired utility wastes, environmental impacts of coal combustion waste disposal, and regulatory requirements that impact coal waste management. From this baseline, potential on- and off-island options for coal ...

1993-10-01

179

Underlying Principles of Natural Selection in Network Evolution: Systems Biology Approach  

UK PubMed Central (United Kingdom)

Systems biology is a rapidly expanding field that integrates diverse areas of science such as physics, engineering, computer science, mathematics, and biology toward the goal of elucidating the underlying...Full Text Available

180

Research - Keyword Index  

Wastenet

...and biological processes acting on recruitment and post-recruitment EU-Agrinet - Project sheet: Biological performance testing methodology to evaluate the durability of plywood as a quality indicator ... Project sheet: Biological performance testing methodology to evaluate the durability of plywood as a quali EU-Agrinet - Project sheet: Genetic evaluation of European ...

181

Biologic Rhythms Derived from Siberian Mammoths' Hairs  

UK PubMed Central (United Kingdom)

Hair is preserved for millennia in permafrost; it enshrines a record of biologic rhythms and offers a glimpse at chronobiology as it was in extinct animals. Here we compare biologic rhythms gleaned...Full Text Available

182

Virtual colonoscopy (CT colonography) in the identification of colorectal cancer. A prospective study in symptomatic patients  

International Nuclear Information System (INIS)

Aim of this study was to evaluate the sensitivity of virtual colonoscopy (CT colonography) in the identification of colorectal cancer and to define the limitations and the advantages of this imaging modality, as well as indications to the examination. It was examined prospectively 62 symptomatic patients aged 36 to 82 years (28 women and 34 men). All patients underwent both conventional and virtual colonoscopy on the same day; the conventional examination allowed exploration of the entire colon. Conventional colonoscopy identified 89 lesions 3-50 mm in diameter, namely 84 benign and 5 malignant lesions. No lesions were identified in 12 patients. CT colonography identified 52 of the 89 lesions, with 57.1% diagnostic accuracy. They were 11 false positives (82.5% positive predictive value and 52.2% specificity) and 37 false negatives (24.5% negative predictive value and 58.4% sensitivity). Sensitivity was significantly higher ...

2000-06-01

183

Assessing digital control system dependability using the dynamic flowgraph methodology  

Energy Technology Data Exchange (ETDEWEB)

Dynamic Flowgraph Methodology (DFM) is a methodological approach to modeling and analyzing the behavior of software-driven embedded systems for the purpose of reliability/safety assessment and verification. The methodology has two fundamental goals: (a) to identify how certain postulated events may occur in a system and (b) to identify an appropriate testing strategy based on an analysis of system functional behavior. To achieve these goals, the methodology employs a modeling framework in which system models are developed in terms of causal relationships between physical variables and temporal characteristics of the execution of software modules. These models are then analyzed to determine how a certain state (desirable or undesirable) can be reached. This is done by developing timed fault trees, which take the form of logical combinations of static trees relating system parameters at different points in time. The prime implicants (multistate ...

1993-01-01

184

Americans' political participation in the 1993-94 national health care reform debate.  

Science.gov (United States)

The health politics and policy communities are still struggling with the question of "what went wrong" in the 1993-94 health care reform effort. Here I identify which Americans were politically active and inactive during the health care reform debate to explore the role political participation may have had in determining the outcome of the debate. Using data from a national and California random-sample telephone surveys, and controlling for other demographic attributes, I found that those who engaged in political activity specifically related to health care reform were disproportionately more likely to be self-identified conservatives, less likely to favor an employer mandate plan, more likely to be fifty to sixty-four years old, more likely to be men, and more likely to have greater interest in and knowledge of the health care issue. Even in California, where a single-payer proposal was on the November ballot, ...

1996-01-01

185

Towards Antihydrogen Trapping and Spectroscopy at ALPHA  

CERN Document Server

Spectroscopy of antihydrogen has the potential to yield high-precision tests of the CPT theorem and shed light on the matter-antimatter imbalance in the Universe. The ALPHA antihydrogen trap at CERN's Antiproton Decelerator aims to prepare a sample of antihydrogen atoms confined in an octupole-based Ioffe trap and to measure the frequency of several atomic transitions. We describe our techniques to directly measure the antiproton temperature and a new technique to cool them to below 10 K. We also show how our unique position-sensitive annihilation detector provides us with a highly sensitive method of identifying antiproton annihilations and effectively rejecting the cosmic-ray background.

2011-01-01

186

Potential vulnerabilities of nuclear fuel cycle facilities to the year 2000 (Y2K) issue and measures to address them  

International Nuclear Information System (INIS)

The exchange of information and experience among Member Sates is an essential component of the IAEA action plan for addressing the Year 2000 problem. The objective is to enable Member States to identify any gaps in their own conversion programmes, benefit form the experience of others in developing remedial actions and establish the basis for future action to solve remaining problems. Experts in Year 2000 issues particularly those related to digital equipment prepared this report dealing with nuclear fuel cycle facilities

1993-04-18

187

PPAR action in insulin resistance unraveled by metabolomics: potential clinical implications.  

Science.gov (United States)

ABSTRACT: Metabolomic analysis will provide the next large set of clues to further our understanding of human health and disease. A recent study has elucidated the significant differences in the metabolomes of adipocytes, serum and an adipocyte cell line after activation of two nuclear receptors, peroxisome proliferator activated receptor ?/? (PPAR?/?) and PPAR?. These findings hold great promise for explaining fundamental differences in the mechanisms of PPAR agonists and for identifying targets for the treatment of diabetes.See related research article: http://genomebiology.com/2011/12/8/R75. PMID:21861850

2011-08-23

188

Modelling and measurement of radon diffusion through soil for application on mine tailings dams  

International Nuclear Information System (INIS)

The mine dumps that arise from the gold mining operations in South Africa are a potential source of high concentrations of radon (222"Rn). Studying the diffusion of radon and the emanation from the soil will help to deduce the radon flux from these dumps to identify the problem areas for rehabilitation. This study describes measurements of the emanation coefficient and the modelling of the depth profile of the radon activity concentration, which is compared to a depth profile that was measured on such a mine dump. Emanation coefficients ranging from 0.13 to 0.39 have been obtained.

2005-04-01

189

Managing risks and hazardous in industrial operations  

Energy Technology Data Exchange (ETDEWEB)

The main objective of this paper is to demonstrate that it makes good business sense to identify risks and hazards of an operation and take appropriate steps to manage them effectively. Developing and implementing an effective risk and hazard management plan also contibutes to other industry requirements and standards. Development of a risk management system, key elements of a risk management plan, and hazards and risk analysis methods are outlined. Comparing potential risk to the cost of prevention is also discussed. It is estimated that the cost of developing and preparing the first risk management plan varies between $50,000 to $200,000. 3 refs., 2 figs., 1 tab.

1996-12-31

190

In Situ Remediation of {sup 137}Cs Contaminated Wetlands Using Naturally Occurring Minerals  

Energy Technology Data Exchange (ETDEWEB)

Cesium-137 has contaminated a large area of the wetlands on the Savannah River Site. Remediation of the contaminated wetlands is problematic because current techniques destroy the sensitive ecosystem and generate a higher dose to workers. To address this problem, we proposed a non-trusive, in situ technology to sequester 137Cs in sediments. One intention of this study was to provide information regarding a go/no go decision for future work. Since the proof-of-concept was successful and several minerals were identified as potential candidates for this technology, a go decision was made.

1999-08-11

191

Go vs. no-go - potential and limitations of continuous-variable quantum computing by measurements  

Energy Technology Data Exchange (ETDEWEB)

In this talk, we explore the feasibility of quantum computation using continuous-variable systems by means of local measurements only. In the first part of the talk, we will identify crucial limitations that arise when starting from Gaussian cluster states. This is done by resorting to a Gaussian projected entangled pair picture as well as to notions of continuous-variable quantum repeater networks. In the second part, we look at instances in which these limitations can be overcome, and how suitable encodings of qubits in oscillators and feasible non-Gaussian resource states give rise to universal schemes for quantum computing.

2010-07-01

192

Geothermal resource assessment of the New England states  

Energy Technology Data Exchange (ETDEWEB)

With the exception of Sand Springs in Williamstown, Massachusetts, there are no identifiable hydrothermal geothermal resources in the New England region. The radioactive plutons of the White Mountains of New Hampshire do not, apparently, contain sufficient stored heat to make them a feasible target for an induced hydrothermal system such as exists at Fenton Hill near Los Alamos, New Mexico. The only potential source of low grade heat is the large volume of ground water contained within the unconsolidated sediments related to the Pleistocene glaciation of the region. During the course of the survey an unusual and unexplained thermal anomaly was discovered in St. Johnsbury, Vermont, which is described.

1982-01-01

193

Faster-than-light particles: a review of tachyon characteristics. Interim report  

Energy Technology Data Exchange (ETDEWEB)

This report documents an analytical prediction of some of the characteristics which presently undiscovered faster-than-light sub-atomic particles (called tachyons) must possess if they are to exist without violating the Theory of Special Relativity. A brief review of necessary concepts from the Special Theory is included so that the reader might more readily understand the reasoning as it is developed. Necessary, but not all, characteristics of tachyons are then identified and presented. Finally, an interesting potential relationship between tachyons and anti-gravity is discussed.

1980-10-01

194

Electron combinational light scattering in disordered Ti_x_-_1Fe_x alloys: theory and experiment  

International Nuclear Information System (INIS)

Theoretical description of Raman scattering in disordered alloys of Ti and Zr with transition metals of groups 5-8 of the Mendeleev Periodic System in critical range of concentrations (CRC) is given. Results of Raman scattering experiment in the system Ti_1_-_xF_x at 0.0005identified by previously made Moessbauer measurements for the same samples, are presented. The order of the values of hybridization potential and energy of impurity zone, as well as their concentrational dynamics, are determined. Qualitative adequacy of the hybridization model to the alloys studied near CRC is shown.

195

Compaction of salt by means of explosives  

Energy Technology Data Exchange (ETDEWEB)

One of the concerns with locating radioactive waste storage sites in salt deposits is how to permanently seal the underground storage areas once they have reached their storage capacity. The compaction of salt using explosives has been identified as a potential method of producing permanent seals in both entryways and shafts to storage areas. This paper describes the test procedure and results of a preliminary investigation to determine the feasibility of utilizing explosives in the compaction of salt. Three simple tests were carried out to measure the degree to which loose salt could be compacted.

1996-12-01

196

A quantitative method to detect explosives and selected semivolatiles in soil samples by Fourier transform infrared spectroscopy  

Energy Technology Data Exchange (ETDEWEB)

This paper describes a novel Fourier transform infrared (FTIR) spectroscopic method that can be used to rapidly screen soil samples from potentially hazardous waste sites. Samples are heated in a thermal desorption unit and the resultant vapors are collected and analyzed in a long-path gas cell mounted in a FTIR. Laboratory analysis of a soil sample by FTIR takes approximately 10 minutes. This method has been developed to identify and quantify microgram concentrations of explosives in soil samples and is directly applicable to the detection of selected volatile organics, semivolatile organics, and pesticides.

1995-06-01

197

Safe ageing management of nuclear power plants: An European synthesis  

International Nuclear Information System (INIS)

Ageing of nuclear power plants means evolution of material or equipment properties on one side, and evolution of personnel skill and procedure adequacy on the other side, both of which, after a certain time, may not be compatible with the required safety provisions, or with an economic operation of the plant. Repair or replacement of components, as well as change in service conditions for a better compatibility with component reduced capabilities can be used to mitigate ageing effects. The paper summarises the results of a study conducted in this field with the support of the European Commission. It presents: the synthesis of the work done under international auspices, and in the European context; the comparison of ageing management approaches used in several European countries with international recommendations; the summary of the various potential phenomena and their governing parameters, the methods of in-service ageing identification and possible mitigation ...

2002-11-04

198

The stability of biological standards  

UK PubMed Central (United Kingdom)

The authors emphasize the importance of stability in biological standards and discuss the steps taken to ensure the stability of International Standards and the theoretical basis of the various stability...Full Text Available

1956-01-01

199

Suitability of a New Plant Invader as a Target for Biological Control in Florida  

Science.gov (United States)

... L. Sutton. 2000. Is the aquatic weed hygrophila, Hygrophila polysperma (Polemoniales: Acanthaceae), a suitable target for classical biological ... ...

200

Menstrual Cycle: Basic Biology  

UK PubMed Central (United Kingdom)

The basic biology of the menstrual cycle is a complex, coordinated sequence of events involving the hypothalamus, anterior pituitary, ovary, and endometrium. The menstrual cycle with all its...Full Text Available

2008-01-01

201

MODELING AND BIOLOGICAL CONTROL OF MOSQUITOES  

UK PubMed Central (United Kingdom)

Models can be useful at many different levels when considering complex issues such as biological control of mosquitoes. At an early stage, exploratory models are valuable in exploring the characteristics...Full Text Available

2007-01-01

202

Liver Carcinogenesis Unit  

Science.gov (United States)

The Liver Carcinogenesis Section uses the modern technologies of molecular biology, cell biology, protein chemistry and genetics to investigate the biochemical and genetic pathways involved in human liver cancer.

203

Kenai Fjords National Park Biological Resources Buffer Coverage  

Science.gov (United States)

... a buffer of all biological resources in the Kenai Fjords National Park Area. Data from Alaska Fish ... ...

204

Healthy aging and disease: role for telomere biology?  

UK PubMed Central (United Kingdom)

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease,...Full Text Available

2011-05-01

205

Genetics, Genomics, and Molecular Biology  

Science.gov (United States)

Genetics, Genomics, and Molecular Biology USGS scientists develop and integrate new genetic and molecular techniques into systematic analyses to describe individuals and populations of fish .....

206

The allusive cognitive deficit in paranoia: the case for mental time travel or cognitive self-projection.  

Science.gov (United States)

Delusional beliefs are characteristic of psychosis and, of the delusions, the paranoid delusion is the single most common type associated with psychosis. The many years of research focused on neurocognition in schizophrenia, using standardized neurocognitive tests, have failed to find conclusive cognitive deficits in relation to positive symptoms. However, UK-based psychological research has identified sociocognitive anomalies in relation to paranoid thinking in the form of theory of mind (ToM), causal reasoning and threat-related processing anomalies. Drawing from recent neuroscientific research on the default mode network, this paper asserts that the common theme running through the psychological tests that are sensitive to the cognitive impairment of paranoia is the need to cognitively project the self through time, referred to as mental time travel. Such an understanding of the cognitive roots of paranoid ideation provides a synthesis between psychological and ...

2010-08-01

207

Psychoanalysis and psychosomatics: a new synthesis.  

Science.gov (United States)

The usefulness of psychoanalysis to psychosomatic medicine has been limited by the longstanding assumption that the psychological disorder in psychosomatic patients resembles the conflict-based psychopathology that Freud identified in psychoneurotic patients. Recent investigations of the alexithymia construct, and the discovery that social relationships can influence health over the entire life span, have challenged this assumption and created an opportunity for a new and active involvement of psychoanalysis with psychosomatic medicine. In this contribution, I offer a synthesis of contemporary psychoanalytic observations and theories with concepts and research findings from developmental psychology, developmental biology, and the biomedical sciences. The proposed synthesis is consistent with the view that living organisms are self-regulating cybernetic systems; it also extends an evolving new psychosomatic model that conceptualizes illnesses ...

1992-01-01

208

NOAA National Status and Trends Program Tenth Round Intercomparison for Trace Metals in Marine Sediments and Biological Tissues. National Status and Trends Program for marine environmental quality: Technical memo  

Energy Technology Data Exchange (ETDEWEB)

A total of forty participants were included in the exercise, including NOAA, USEPA, state, Australian, Canadian, Mexican and Argentinean laboratories. Two samples were sent by NRC to each participant: a contaminated marine sediment from the vicinity of New York Bay and a freeze dried mussel (Mytilus edulis) from Charlottenlund, Denmark. Laboratories were also asked to analyze two certified reference materials NIST SRM 1566a, and NRC BCSS-1. The elements to be determined were Al, Cr, Fe, Ni, Cu, Zn, As, Se, Ag, Cd, Sn, Hg, and Pb for both matrices, plus Be, Si, Mn, Sb, and Tl for the sediments. An accepted mean and confidence interval were calculated for each analyte in the two unknown samples. Laboratory biases were identified and an overall rating of superior, good, fair or others was assigned to each laboratory.

1996-11-01

209

Magnetic and chemical changes in marine sediments  

Energy Technology Data Exchange (ETDEWEB)

A considerable amount of chemical knowledge of marine sediments has been acquired in recent years but has not yet been utilized by paleomagnetists. On the other hand, geochemists are often unaware of the usefulness of numerous magnetic techniques. In this review we try to bridge this gap, and in particular, we outline many of the chemical and magnetic principles that should allow paleomagnetists to better identify and undertand chemical changes that affect the magnetic properties of marine sediments. The chemical principles include those for distinguishing the four major sources of sediments (continental, biological, authigenic/hydrogenous, volcanic/hydrothermal) from one another by determining elemental abundance distributions, as well as for investigating the stabilities of mineral phases relative to changes in pE and pH. The magnetic principles include the effects of authigenesis and diagenesis on magnetic properties, particularly on the ...

1980-05-01

210

Development of enhanced radioprotectors - Biochemical and molecular genetical approaches on the radioprotective mechanism of natural products  

Energy Technology Data Exchange (ETDEWEB)

To identify radio-protective agent candidate among medicinal plants and to elucidate the mechanism of action of the candidate material by using modern biochemical and molecular biological methods, we screened radio-protective activity among 48 medicinal plants. Seven samples showed above 20% protective activities against oxidative cell damage: Euryale ferox, Glycyrrhiza uralensis, Salvia miltiorrhiza, Eucomia ulmoides, Paeonia suffruticosa, Spirodela polyrrhiza, and Nelumbo nucifera. We also screened for oxidative stress sensitizing activity among other 51 medicinal plants. Among those samples, 11 samples showed good sensitizing effect; Melia azedarach, Agastache rugosa, Catalpa ovata, Prunus persica, Sinomenium acutum, Pulsatilla koreana, Oldenlandia diffusa, Anthriscus sylvestris, Schizandra chinensis, Gleditsia sinensis, and Cridium officinale. We also reported the radio-protective effect of DTT. The treatment of DTT increased cell survival ...

2000-04-01

211

Protein-coding and non-coding gene expression analysis in differentiating human keratinocytes using a three-dimensional epidermal equivalent.  

Science.gov (United States)

The epidermal compartment is complex and organized into several strata composed of keratinocytes (KCs), including basal, spinous, granular, and cornified layers. The continuous process of self-renewal and barrier formation is dependent on a homeostatic balance achieved amongst KCs involving proliferation, differentiation, and cell death. To determine genes responsible for initiating and maintaining a cornified epidermis, organotypic cultures comprised entirely of stratified KCs creating epidermal equivalents (EE) were raised from a submerged state to an air/liquid (A/L) interface. Compared to the array profile of submerged cultures containing KCs predominantly in a proliferative (relatively undifferentiated) state, EEs raised to an A/L interface displayed a remarkably consistent and distinct profile of mRNAs. Cultures lifted to an A/L interface triggered the induction of gene groups that regulate proliferation, differentiation, and cell death. Next, differentially expressed microRNAs ...

2010-05-25

212

Oak Ridge National Laboratory Core Competencies  

Energy Technology Data Exchange (ETDEWEB)

A core competency is a distinguishing integration of capabilities which enables an organization to deliver mission results. Core competencies represent the collective learning of an organization and provide the capacity to perform present and future missions. Core competencies are distinguishing characteristics which offer comparative advantage and are difficult to reproduce. They exhibit customer focus, mission relevance, and vertical integration from research through applications. They are demonstrable by metrics such as level of investment, uniqueness of facilities and expertise, and national impact. The Oak Ridge National Laboratory (ORNL) has identified four core competencies which satisfy the above criteria. Each core competency represents an annual investment of at least $100M and is characterized by an integration of Laboratory technical foundations in physical, chemical, and materials sciences; biological, environmental, and social ...

1994-12-01

213

Gene Repressive Activity of RIP140 Through Direct Interaction with CDK8.  

Science.gov (United States)

Receptor interacting protein 140 (RIP140) is a coregulator for numerous nuclear receptors and transcription factors and primarily exerts gene-repressive activities on various target genes. We previously identified a spectrum of posttranslational modifications on RIP140 that augment its property and biological activity. In T(3)-triggered biphasic regulation of cellular retinoic acid binding protein 1 (Crabp1) gene along the course of fibroblast-adipocyte differentiation, we found TRAP220(MED1) critical for T(3)-activated chromatin remodeling whereas RIP140 essential for T(3)-repressive chromatin remodeling of this gene promoter. In this current study, we aim to examine whether and how RIP140 replaces TRAP220(MED1) on the CrabpI promoter in differentiating adipocyte cultures. We find increasing recruitment of RIP140 to this promoter, with corresponding reduction in TRAP220(MED1) recruitment during the T(3)-repressive phase. We also uncover direct ...

2011-08-25

214

Correlated variations and periodicity of global CO{sub 2}, biological mass extinctions and extra-terrestrial bolide impacts over the past 250 million years and possible geodynamical implications  

Energy Technology Data Exchange (ETDEWEB)

Earth`s history has been witness to recurrently alternating phases of catastrophic evolution and dominant tectonic deformations, contractions and extension of rifting and spreading leading to quasi-cyclic changes in sedimentary environment and various earth processes. Recent studies have shown quasi-periodicities of 32{+-}2 Million years (Myr) in various endogenic (geomagnetic reversals, magmatic events, mantle convection, various tectonic activities, climate change and biological extinctions) and exogenic (impact catering) processes indicating a remarkable kinship. A time series analysis is presented of the available CO{sub 2} record over the past 250 Myr decoded from global CaCO{sub 3} accumulation rates in sedimentary environment. The time series analysis reveals an intriguing evidence of a dominant periodicity of 33{+-}2 Myr which matches closely with a `common catastrophic periodicity` of 32 Myr identified in various terrestrial and ...

1998-12-31

215

Biologically effective dose in total-body irradiation and hematopoietic stem cell transplantation  

Energy Technology Data Exchange (ETDEWEB)

Background and Purpose: Total-body irradiation (TBI) is an important part of the conditioning regimen for hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The results after treatment with various TBI regimes were compared, and dose-effect relationships for the endpoints relapse incidence, disease-free survival, treatment-related mortality, and overall survival were derived. The aim was to define requirements for an optimal treatment schedule with respect to leukemic cell kill and late normal-tissue morbidity. Material and Methods: A literature search was performed. Three randomized studies, four studies comparing results of two or three TBI regimens, and nine reports with results of one specific TBI regimen were identified. Biologically effective doses (BEDs) were calculated. The results of the randomized studies and the studies comparing results of two or three TBI regimens were pooled, and the pooled ...

2006-11-15

216

Biologically effective dose in total-body irradiation and hematopoietic stem cell transplantation  

International Nuclear Information System (INIS)

Background and Purpose: Total-body irradiation (TBI) is an important part of the conditioning regimen for hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The results after treatment with various TBI regimes were compared, and dose-effect relationships for the endpoints relapse incidence, disease-free survival, treatment-related mortality, and overall survival were derived. The aim was to define requirements for an optimal treatment schedule with respect to leukemic cell kill and late normal-tissue morbidity. Material and Methods: A literature search was performed. Three randomized studies, four studies comparing results of two or three TBI regimens, and nine reports with results of one specific TBI regimen were identified. Biologically effective doses (BEDs) were calculated. The results of the randomized studies and the studies comparing results of two or three TBI regimens were pooled, and the pooled ...

2006-11-01

217

Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.  

Science.gov (United States)

African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more productive Bos indicus zebu breeds are much more susceptible. Zebu cattle are well adapted for plowing and haulage, and increasing their tolerance of trypanosomiasis could have a major impact on crop cultivation as well as dairy and beef production. We used three strategies to obtain short lists of candidate genes within QTL that were previously shown to regulate response to infection. We analyzed the transcriptomes of trypanotolerant N'Dama and susceptible Boran cattle after infection with Trypanosoma congolense. We sequenced EST libraries from these two breeds to identify polymorphisms that might underlie previously identified quantitative trait loci (QTL), and we assessed QTL regions and candidate loci for ...

2011-05-18

218

Space Biology and Medicine  

Science.gov (United States)

Volume IV is devoted to examining the medical and associated organizational measures used to

2004-01-01

220

Radiation Protection of the Organism (Selected Chapters)  

Science.gov (United States)

... biologically important compounds is sharply lowered with passage of the solutions to the cell an organ, where their sensitivity ...

1970-12-11

223

Localization of "2"0"3Pb-chloride in myocardial infarction  

International Nuclear Information System (INIS)

... AND NUCLEAR MEDICINE biological localization cardiovascular diseases

224

Lead-203 for skeletal imaging  

International Nuclear Information System (INIS)

... biological variability body distribution kidneys labelled compounds lead 203

225

Internalization of cholera toxin by different endocytic mechanisms  

DEFF Research Database (Denmark)

Cell biology, clathrin, endocytosis, dynamin, caveolae, cholera toxin

2001-01-01

226

Illuminating Cell Biology  

Science.gov (United States)

NASA's Ames Research Center awarded Ciencia, Inc., a Small Business Innovation Research contract to

2002-01-01

229

Determination of Shooting Distance from Deformation of the ...  

Science.gov (United States)

... Descriptors : *TERMINAL BALLISTICS, *WOUND BALLISTICS, VELOCITY, CONVERSION, REPRINTS, TISSUES(BIOLOGY), MANUFACTURING ...

231

Biophotonics and Bone Biology  

Science.gov (United States)

One of the more-serious side effects of extended space flight is an accelerated bone loss

2004-01-01

232

Biology-inspired Architecture for Situation Management  

Science.gov (United States)

Situation Management is a rapidly developing science combining new techniques for data collection

2006-01-01

233

Biology of lichen communities in Antarctica.  

Science.gov (United States)

-Ecophysiological and floristic study of the lichen communities in .... Plasticity of the Lichen Catillaria corymbosa in Different Microhabitats of the ...

234

Biology and The Future of Mars  

Science.gov (United States)

It is possible that at some time in the future we might recreate a habitable climate on Mars

2004-01-01

236

Dispersion of Metals from Abandoned Mines and their Effect on Biota in the Methow River, Okanogan County, Washington: Final Report 2002-2003.  

Energy Technology Data Exchange (ETDEWEB)

A study of mine-waste contamination effects on Methow River habitat on the eastern slopes of the north Cascade Mountains in Washington state, U.S.A., revealed impacts at ecosystem, community, population, individual, tissue, and cellular levels. Ore deposits in the area were mined for gold, silver, copper and zinc until the early 1950's, but the mines are now inactive. An above-and-below-mine approach was used to compare potentially impacted to control sites. The concentrations of eleven trace elements (i.e., Al, As, B, Ba, Cd, Cr, Cu, Mn, Pb, Se, and Zn) in Methow River sediments downstream from the abandoned mine sites were higher than background levels. Exposed trout and caddisfly larvae in the Methow River showed reduced growth compared to controls. Samples of liver from juvenile trout and small intestine from exposed caddisfly larvae were examined for evidence of metal accumulation, cytopathological change, and chemical toxicity. Morphological changes ...

2003-05-15

237

Combined photochemical-biological processes for treatment of unleaded gasoline oxygenates : MTBE, ETBE and TAME  

Energy Technology Data Exchange (ETDEWEB)

A study was conducted to determine the feasibility and the opportunity of photochemical pretreatment on the biodegradation and detoxification of Methyl Tert Butyl Ether (MTBE), Ethyl Tert Butyl Ether (ETBE) and Tert Amyl Methyl Ether (TAME), the most common oxygenates used as octane enhancers in unleaded gasoline. The production, storage, uses and disposal of oxygenates result in an unknown amount of groundwater pollution. Because of their high solubility, MTBE, ETBE and TAME are detected in large portions in saturated zones of aquifers. The biodegradation of these oxygenates is difficult and slow, and information regarding their biodegradability is scarce. Photo-decomposition of oxidants under appropriate UV radiation has been shown to be very effective because the hydroxyl radicals produced possess high oxidation potential. In this study, the H{sub 2}O{sub 2}/UV process was used to generate hydroxyl radicals. Maximal oxygenates transformation was obtained in a ...

1998-10-01

238

Combined photochemical-biological processes for treatment of unleaded gasoline oxygenates : MTBE, ETBE and TAME  

International Nuclear Information System (INIS)

A study was conducted to determine the feasibility and the opportunity of photochemical pretreatment on the biodegradation and detoxification of Methyl Tert Butyl Ether (MTBE), Ethyl Tert Butyl Ether (ETBE) and Tert Amyl Methyl Ether (TAME), the most common oxygenates used as octane enhancers in unleaded gasoline. The production, storage, uses and disposal of oxygenates result in an unknown amount of groundwater pollution. Because of their high solubility, MTBE, ETBE and TAME are detected in large portions in saturated zones of aquifers. The biodegradation of these oxygenates is difficult and slow, and information regarding their biodegradability is scarce. Photo-decomposition of oxidants under appropriate UV radiation has been shown to be very effective because the hydroxyl radicals produced possess high oxidation potential. In this study, the H_2O_2/UV process was used to generate hydroxyl radicals. Maximal oxygenates transformation was obtained in a few minutes. ...

1998-10-01

239

SUPPLEMENTAL COLUMBIA RIVER PROTECTION ACTIVITIES AT THE DEPARTMENT OF ENERGY HANFORD SITE: 2006 TECHNICAL PEER REVIEW  

Energy Technology Data Exchange (ETDEWEB)

Prompted by a $10 million Congressional allocation to identify supplemental actions to protect the Columbia River from groundwater contamination beneath the Hanford Reservation, the U. S. Department of Energy (DOE) Environmental Management (EM) Office of Clean-up Technology identified twenty-three potential technical projects and then down-selected ten of these for further evaluation. An independent expert peer review was conducted for the ten down-selected proposals. The review panel consisted of twenty-three recognized subject matter experts that broadly represented academia, industry, and federal laboratories. Of the initial ten proposals reviewed, one was given unconditional support, six were given conditional support, and three were not supported as proposed. Three additional proposals were then submitted by DOE for review--these proposals were structured, in part, to respond to the initial round of technical peer ...

2006-12-20

240

Climate change in the Cairns and Great Barrier Reef region. Scope and Focus for an Integrated Assessment  

International Nuclear Information System (INIS)

This study was undertaken to determine the scope and focus for an integrated assessment of climate change impacts on, and adaptation options for, the Cairns Great Barrier Reef (CGBR) region. To achieve this, the authors employed both technical expertise and regional stakeholder input. This document describes the study objectives and the process used to meet these objectives, and provides an overview of the CGBR region, the views of technical experts on potential climate change impacts, stakeholder prioritisation of impacts and adaptation options, a list of perceived knowledge gaps, and a recommended structure for a future integrated assessment in the region. The aim of the study was to determine the scope and focus for an integrated regional assessment of climate change impacts on, and adaptation options for, the CGBR region. The key objectives of the study were: Define and describe the study region; Develop a process for the study, which includes key stakeholders ...

241

Attack Methodology Analysis: Emerging Trends in Computer-Based Attack Methodologies and Their Applicability to Control System Networks  

Energy Technology Data Exchange (ETDEWEB)

Threat characterization is a key component in evaluating the threat faced by control systems. Without a thorough understanding of the threat faced by critical infrastructure networks, adequate resources cannot be allocated or directed effectively to the defense of these systems. Traditional methods of threat analysis focus on identifying the capabilities and motivations of a specific attacker, assessing the value the adversary would place on targeted systems, and deploying defenses according to the threat posed by the potential adversary. Too many effective exploits and tools exist and are easily accessible to anyone with access to an Internet connection, minimal technical skills, and a significantly reduced motivational threshold to be able to narrow the field of potential adversaries effectively. Understanding how hackers evaluate new IT security research and incorporate significant new ideas into their own tools provides ...

2005-06-01

242

[Fundamental biological model for trials of wound ballistics].  

Science.gov (United States)

The aim of our experiment was the testing of effects of common ammunition on usable and slightly accessible biological tissue thereby to create fundamental simple biological model for trials of wounded ballistic. Like objective tissue was elected biological material - pork and beef hind-limbs, pork head, pork bodily cavity. It was discovered that objective tissue is able to react to singles types of shots in all spectrum results namely simple smooth penetration wound as well as splintery fracture in dependence on kind of using ammunition. Pork hind-limb was evaluated like the most suitable biological material for given object. PMID:17172163

2006-10-01

243

UMTRA project disposal cell cover biointrusion sensitivity assessment, Revision 1  

International Nuclear Information System (INIS)

This study provides an analysis of potential changes that may take place in a Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cell cover system as a result of plant biointrusion. Potential changes are evaluated by performing a sensitivity analysis of the relative impact of root penetrations on radon flux out of the cell cover and/or water infiltration into the cell cover. Data used in this analysis consist of existing information on vegetation growth on selected cell cover systems and information available from published studies and/or other available project research. Consistent with the scope of this paper, no new site-specific data were collected from UMTRA Project sites. Further, this paper does not focus on the issue of plant transport of radon gas or other contaminants out of the disposal cell cover though it is acknowledged that such transport has the potential to be a significant pathway for ...

2004-06-22

244

UMTRA project disposal cell cover biointrusion sensitivity assessment, Revision 1  

Energy Technology Data Exchange (ETDEWEB)

This study provides an analysis of potential changes that may take place in a Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cell cover system as a result of plant biointrusion. Potential changes are evaluated by performing a sensitivity analysis of the relative impact of root penetrations on radon flux out of the cell cover and/or water infiltration into the cell cover. Data used in this analysis consist of existing information on vegetation growth on selected cell cover systems and information available from published studies and/or other available project research. Consistent with the scope of this paper, no new site-specific data were collected from UMTRA Project sites. Further, this paper does not focus on the issue of plant transport of radon gas or other contaminants out of the disposal cell cover though it is acknowledged that such transport has the potential to be a significant pathway for ...

1995-10-01

245

The mechanism of metal nanoparticle formation in plants: limits on accumulation  

Energy Technology Data Exchange (ETDEWEB)

Metal nanoparticles have many potential technological applications. Biological routes to the synthesis of these particles have been proposed including production by vascular plants, known as phytoextraction. While many studies have looked at metal uptake by plants, particularly with regard to phytoremediation and hyperaccumulation, few have distinguished between metal deposition and metal salt accumulation. This work describes the uptake of AgNO{sub 3}, Na{sub 3}Ag(S{sub 2}O{sub 3}){sub 2}, and Ag(NH{sub 3}){sub 2}NO{sub 3} solutions by hydroponically grown Brassica juncea and the quantitative measurement of the conversion of these salts to silver metal nanoparticles. Using X-ray absorption near edge spectroscopy (XANES) to determine the metal speciation within the plants, combined with atomic absorption spectroscopy (AAS) for total Ag, the quantity of reduction of Ag{sup I} to Ag{sup 0} is reported. Transmission electron microscopy (TEM) ...

2009-08-15

246

Quantum molecular dynamics and molecular interactions studied by NMR and INS[Nuclear magnetic resonance; Proton tunnelling; Hydrogen bond  

Energy Technology Data Exchange (ETDEWEB)

The wavefunction of a particle extends into the classically forbidden barrier region of the potential energy surface. The consequence of this partial delocalisation is the phenomenon of quantum tunnelling, an effect which enables a particle to penetrate a potential barrier of magnitude greater than the energy of the particle. The tunnelling probability is an exponential function of the particle mass. The effect is therefore an important contribution to the behaviour of light atoms, in particular the proton. The hydrogen bond has long been appreciated to be an essential component of many biological and chemical systems, and the proton transfer reaction in the hydrogen bond is fundamental to many of these processes. The proton behaviour in the hydrogen bonds of benzoic acid, acetylacetone and calix-4-arene has been studied. A variety of techniques, both experimental and computational, were adopted for the study of the three ...

2002-07-01

247

Forest genetics: research and application in Indian forestry  

Energy Technology Data Exchange (ETDEWEB)

Sufficient genetic diversity exists in Indian tree species to give large genetic gains. Improvement potential, using wild gene resources for selection and breeding is vast as there are over 244 genera and 400 forest tree species in India. Of these over 30 species and 22 genera are of outstanding forestry value. Selective genetic-variation can be lifted from wild populations, multiplied vegetatively or by seed, and planted with controlled germplasm sources. Among the Indian species no less than 74 reproduce by cutting, 11 by layers, 9 by grafting and buding and 104 by root suckers. More than 161 species coppice vigorously. Afforestation techniques of over 170 species have been worked out. Tree genetic approach of survey of natural variability, quick evaluation, selection, conservation multiplication and planting superior variability directly in the field can give immediate genetic gains. This article discusses genetic information on indigenous species for use of ...

1981-04-01

248

[Molecular cloning and expression of an isotoxin gene, alpha-bungarotoxin, from Bungarus multicinctus].  

Science.gov (United States)

Abstract: Snake venom contains a number of small proteins,enzymes and other components,which displays a broad spectrum of biological activities. With the ability of specifically binding on acetylcholine acceptor, alpha-bungarotoxins are not only useful molecular probes in investigating the mechanism of neural signal transmission, but also potential pharmic preparations for neural disease treatment. In current research,cDNAs of Bungarus multicinutus venom gland were synthesized using SMART cDNA amplification kit and then, alpha-bungarotoxin genes were cloned and sequenced. Total of 20 clones were sequenced representing 14 isotoxin mRNAs of alpha-bungarotoxins. Among those clones, a novel isotoxin gene was subcloned into two expression plasmids, alpha-BgTX/pQE30a and alpha-BgTX/pGEX-4T-1, and transformed into E. coli. After inducing with IPTG, fused protein of GST-alpha-BgTX was successfully expressed at level of 30% gross proteins of bacteria. ...

2005-07-01

249

Which neuro-physiologic effects at low level 2.45 GHz RF exposure?; Quels effets neurophysiologiques pour un champ electromagnetique de faible puissance a 2,45 GHz?  

Energy Technology Data Exchange (ETDEWEB)

The LS electromagnetic band (1-4 GHz) is widely used both in domestic and industrial domains. Several studies suggested that the biological systems would exhibit a specific sensitivity to the 2.45 GHz microwaves (water resonance frequency). Potential human health hazards and especially a disruption of the cholinergic system have been reported, due to exposure to microwaves even at low power density. This work presents a multi-parametric study of freely moving rat where neuro-physiology was investigated during 70 hours using neurochemical (micro-dialysis technique), electrophysiological, behavioral (vigilance stages quantification) and thermo-physiological approaches. The rats were exposed 24 hours to a 2.45 GHz pulsed electromagnetic field at low power density. In this exposure conditions, no significant effect have been reported. (authors)

2007-06-15

250

Transplantation of neurospheres derived from bone marrow stromal cells promotes neurological recovery in rats with spinal cord injury  

British Library Electronic Table of Contents (United Kingdom)

Previous studies have revealed that cell therapy using bone marrow stromal cells (BMSCs) could promote motor functional recovery in animals with spinal cord injury (SCI). We describe here the development of cell biology technique and the experimental study of regeneration in SCI. The aim of this study was to investigate the potential for neurological recovery by transplantation neurospheres (NS) derived from BMSCs into thoracic SCI. Adult Fisher rats were used: 45 were subjected to complete thoracic SCI performed by the balloon compression method. BMSCs were cultured in vitro to obtain NS. Seven days after thoracic SCI, groups of 15 rats each received transplants of BMSCs-NS (group A), BMSCs (group B), or injection of medium only (group C) into the SCI lesion. Rats from each group were eva...

2011-01-01

251

Transcriptome analysis reveals salt-stress-regulated biological processes and key pathways in roots of cotton (Gossypium hirsutum L.).  

Science.gov (United States)

High salinity is one of the main factors limiting cotton growth and productivity. The genes that regulate salt stress in TM-1 upland cotton were monitored using microarray and real-time PCR (RT-PCR) with samples taken from roots. Microarray analysis showed that 1503 probe sets were up-regulated and 1490 probe sets were down-regulated in plants exposed for 3h to 100mM NaCl, and RT-PCR analysis validated 42 relevant/related genes. The distribution of enriched gene ontology terms showed such important processes as the response to water stress and pathways of hormone metabolism and signal transduction were induced by the NaCl treatment. Some key regulatory gene families involved in abiotic and biotic sources of stress such as WRKY, ERF, and JAZ were differentially expressed. Our transcriptome analysis might provide some useful insights into salt-mediated signal transduction pathways in cotton and offer a number of candidate genes as potential markers of tolerance to ...

2011-04-30

252

Thermal basis for disruption of operant behavior by microwaves in three animal species  

Energy Technology Data Exchange (ETDEWEB)

A large variety of microwave producing devices are used in contemporary naval communications and weapons systems. Public and scientific concern about potential biological effects of microwave irradiation such as produced by these various devices requires documentations of such effects. Currently, the only well documented direct effect of microwaves is heating of the exposed organism. The present report is of a series of studies whose aim was to explore several microwave frequencies and their effect on performance and simultaneously to investigate the relationship to core heating in the exposed animals. Three difficult sized species of animals were used so that generalization to larger animals could be made. Rats, squirrel monkeys, and rhesus monkeys showed consistent effects of 60-minute exposures to microwaves when their body temperatures were increased at least 1 C above baseline temperatures. Performance was not reliably affected when body ...

1982-06-01

253

The chemistry of technetium(V) complexes containing tetradentate amine oxime ligands  

International Nuclear Information System (INIS)

Technetium-99m was previously shown to form a stable, neutral and lipopholic complex with propylene amine oxime, PnAO. This Tc-99m-PnAO complex was shown to efficiently extracted by normal brain. However, it is not sufficiently retained in the brain to image its cerebral distribution using convertional SPECT (single-photon emission computerized tomography) instrumentation. A number of derivatives of PnAO have been synthesized and their technetium-99m complexes have been biologically evaluated. A number of these have been shown to have high brain uptake without exhibiting the rapid cerebral clearance that was observed with Tc-99m-PnAO. To better understand the chemistry of these potential brain imaging agents, a number of technetium-99 complexes of derivatives of PnAO have been synthesized and characterized. Substituents on the tetradentate amine oxime backbone were varied to probe the effect(s) of these structural changes on the properties of ...

254

Simultaneous harvesting of straw and chaff for energy purposes : influence on bale density, yield, field drying process and combustion characteristics  

Energy Technology Data Exchange (ETDEWEB)

The potential to increase the productivity of fuel straw harvest and transportation was examined. When harvesting straw for energy purposes, only the long fraction is currently collected. However, technological improvements have now rendered it possible to harvest chaff, thus increasing the amount of harvest residues and bale density. The purpose of this study was to determine how harvest yield, bale density, field-drying behaviour and combustion characteristics are affected by the simultaneous harvest of straw and chaff. Field experiments were conducted in 2009 for long- and short-stalked winter wheat crops. Combine harvesting was carried out with 2 different types of combine harvesters. A high-density baler was used to bale the crop residues. Mixing chaff in with the straw swath by combine harvesting gave a lower initial moisture content compared with straw only. The density and the weight of each bale were not affected by the treatments. However, the added chaff ...

2010-07-01

255

Prospects for controlling animal parasitic nematodes by predacious micro fungi.  

Science.gov (United States)

Resistance against anthelmintics is widespread, particularly in parasitic nematode populations of small ruminants. Several new techniques or supplements have been developed or are under investigation. Biological control (BC) is one of these new methods. The net-trapping predacious fungus Duddingtonia flagrans produces thick walled resting spores, chlamydospores, which are able to survive passage through the gastrointestinal tract of cattle, horses, sheep and pigs. Under Danish climatic conditions it has been shown that the number of parasite larvae on pasture and the worm burden of the grazing animals is significantly reduced when animals are fed spores during the initial 2-3 months of the grazing season. Work with D. flagrans in France, Australia, USA, and Mexico has confirmed the strong BC potential of this fungus. Today much work is going into development of suitable delivery systems for grazing livestock worldwide. Ultimately, BC should be ...

2000-01-01

256

Living and Working Safely Around High-Voltage Power Lines.  

Energy Technology Data Exchange (ETDEWEB)

High-voltage transmission lines can be just as safe as the electrical wiring in the homes--or just as dangerous. The crucial factor is ourselves: they must learn to behave safely around them. This booklet is a basic safety guide for those who live and work around power lines. It deals primarily with nuisance shocks due to induced voltages, and with potential electric shock hazards from contact with high-voltage lines. References on possible long-term biological effects of transmission lines are shown. In preparing this booklet, the Bonneville Power Administration has drawn on more than 50 years of experience with high-voltage transmission. BPA operates one of the world`s largest networks of long-distance, high-voltage lines. This system has more than 400 substations and about 15,000 miles of transmission lines, almost 4,400 miles of which are operated at 500,000 volts.

2001-06-01

257

Insecticidal effects of essential oils extracted from aromatic plants on Ceratitis capitata (Wied.) in Lebanon  

International Nuclear Information System (INIS)

Full text: The excessive use of chemical pesticides to control agricultural pests is becoming alarming. The objective of this study is to search for biopesticides of plant origin that could be used to control one of the major pest of fruit production; the Mediterranean fruit fly (Ceratitis capitata Wied.). A colony of the Lebanese wild strain of this insect was reared under laboratory condition to provide biological material. The insecticidal activity of the essential oils extracted from aromatic plants in Lebanon was assessed. The tested plants are: Foeniculum vulgare, Thymbra spicata, Artemisia herba alba, Origanum syriacum, Ruta chalepensis, Lavandula stoechas, Salvia fruticosa, Mentha microphylla, Juniperus oxycedrus, Rosmarinus officinalis, Myrtus communis, Laurus nobilis and Ocimum gratissimum. Results show that essential oils isolated from F. vulgare, T. spicata, A. herba alba, O. syriacum and R. chalepensis have promising insecticidal ...

2005-05-09

258

In situ Investigation of the Silver-CTAB system  

Energy Technology Data Exchange (ETDEWEB)

Recent research has shown that biologically inspired approaches to materials synthesis and self-assembly, hold promise of unprecedented atomic level control of structure and interfaces. In particular, the use of organic molecules to control the production of inorganic technological materials has the potential for controlling grain structure to enhance material strength; controlling facet expression for enhanced catalytic activity; and controlling the shape of nanostructured materials to optimize optical, electrical and magnetic properties. In this work, we use organic molecules to modify silver crystal shapes towards understanding the metal-organic interactions that lead to nanoparticle shape control. Using in situ electrochemical AFM (EC-AFM) as an in situ probe, we study the influence of a cationic surfactant cetyltrimethylamminobromide (CTAB) on Ag growth during electrochemical deposition on Ag(100). The results show that the organic ...

2007-04-16

259

Functionalized multi-walled carbon nanotubes as affinity ligands  

Energy Technology Data Exchange (ETDEWEB)

Functionalization of carbon nanotubes is very challenging for their applications. The paper here describes a new method to functionalize multi-walled carbon nanotubes (MWCNTs) as specific affinity adsorbents. MWCNTs were acid purified and pretreated with (3-aminopropyl)-triethoxysilane (APTES) in order to introduce abundant amino groups on the surface of MWCNTs. After the conversion of amino groups to carboxyl groups by succinic acid anhydride, MWCNTs were attached to protein A or aminodextran using 1-ethyl-3,3' (dimethylamion)-propylcarbodiimide as a biofunctional crosslinker. The incorporation of aminodextran as a spacer arm noticeably increased the binding capacity of the APTES-modified MWCNTs for protein A. The application of affinity MWCNTs for purification of immunoglobulin G was then evaluated. The affinity of MWCNTs with AMD spacer exhibited a high adsorption capacity of {approx}361 {mu}g IgG/mg MWCNT (wet basis). About 75% of bound IgG was eluted from affinity MWCNTs ...

2007-03-21

260

Finite element model selection using Particle Swarm Optimization  

CERN Document Server

This paper proposes the application of particle swarm optimization (PSO) to the problem of finite element model (FEM) selection. This problem arises when a choice of the best model for a system has to be made from set of competing models, each developed a priori from engineering judgment. PSO is a population-based stochastic search algorithm inspired by the behaviour of biological entities in nature when they are foraging for resources. Each potentially correct model is represented as a particle that exhibits both individualistic and group behaviour. Each particle moves within the model search space looking for the best solution by updating the parameters values that define it. The most important step in the particle swarm algorithm is the method of representing models which should take into account the number, location and variables of parameters to be updated. One example structural system is used to show the applicability of PSO in finding ...

2009-01-01

261

Evidence and Implications of Frequent Fires in Ancient Shrub Tundra  

Energy Technology Data Exchange (ETDEWEB)

Understanding feedbacks between terrestrial and atmospheric systems is vital for predicting the consequences of global change, particularly in the rapidly changing Arctic. Fire is a key process in this context, but the consequences of altered fire regimes in tundra ecosystems are rarely considered, largely because tundra fires occur infrequently on the modern landscape. We present paleoecological data that indicate frequent tundra fires in northcentral Alaska between 14,000 and 10,000 years ago. Charcoal and pollen from lake sediments reveal that ancient birchdominated shrub tundra burned as often as modern boreal forests in the region, every 144 years on average (+/- 90 s.d.; n = 44). Although paleoclimate interpretations and data from modern tundra fires suggest that increased burning was aided by low effective moisture, vegetation cover clearly played a critical role in facilitating the paleo-fires by creating an abundance of fine fuels. These records suggest that greater fire ...

2008-03-06

262

Emissions of nitrogen oxides from equatorial rain forest in central Africa: origin and regulation of NO emission from soils  

Energy Technology Data Exchange (ETDEWEB)

Emissions of nitric oxide from soils of equatorial rain forest were measured in the Dimonika Natural Park (4 degrees 30'S, 12 degrees 30'E) in the Mayombe Forest in Congo. Three research campaigns were carried out in June and July 1991 and in February 1992. Fluxes were measured by dynamic chamber techniques using a chemiluminescence instrument Scintrex LMA3. NO fluxes measured on natural soils are in between 5 and 17x10[sup 9] molecules cm[sup -2]s[sup -1]; they are of the same order of magnitude as those observed in similar tropical forest media. Soil treatment experiments show that the auto-decomposition of HNO[sub 2] in these acid soils (pH 4) (chemodenitrification) is a potentially important cause of nitric oxide production in this type of ecosystem. Nitrous acid comes from autotrophic nitrification all the year around, and also from biological denitrification, shown by N[sub 2]O emissions, during the rainy season. The ...

1994-09-01

263

Development and cytotoxicity evaluation of SiAlONs ceramics  

International Nuclear Information System (INIS)

SiAlONs are ceramics with high potential as biomaterials due to their chemical stability, associated with suitable mechanical properties, such as high fracture toughness and fracture resistance. The objective of this work was to investigate the mechanical properties and the cytotoxicity of these ceramic materials. Three different compositions were prepared, using silicon nitride, aluminum nitride and a rare earth oxide mixture as starting powders, yielding Si_3N_4-SiAlON composites or pure SiAlON ceramics, after hot-pressing at 1750 deg. C, for 30 min. The sintered samples were characterized by X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). Furthermore, hardness and fracture toughness were determined using the Vicker's indentation method. The biological compatibility was evaluated by in vitro cytotoxicity tests. Ceramic with elevated hardness, ranging between 17 and 21 GPa, and high fracture toughness of 5 to 6 MPa ...

2007-01-01

264

Biological and chemical evaluation of sewage water pollution in the Rietvlei nature reserve wetland area, South Africa  

International Nuclear Information System (INIS)

Macroinvertebrate communities in Rietvlei nature reserve wetland area and their relationship with water quality were studied with the aim to evaluate their use as potential indicators of pollution. Sampling locations were selected to include outlets from swage effluent, agricultural and informal residential runoff. A large increase in nutrient concentrations was observed downstream from discharged treated sewage with an associated decrease in species richness. Bioassays performed included: Daphnia magna, Hydra attenuate, Lactuca sativa, Allium cepa and Pyxicephalus adspersus. The highest percentage of lethality response to a screen (100% concentration) of sampled wetland water by test specimens were observed at the point source input of the Hartbeespoort treated sewage plant. Data generated from the AUSRIVAS method and multitrophic level bioassays revealed the deterioration of the wetland possibly due to factors such as increasing urbanization, industrialization, ...

2008-11-01

265

Application of pharmacological techniques to the study of the biological effects of microwaves during low level exposures  

Energy Technology Data Exchange (ETDEWEB)

The influence of low-level microwaves (2.45 GHz, CW, 2 and 5 mW.cm/sup -2/) was studied on various models of previsional animal psychopharmacology involving tests of motor activity, stereotypy, convulsions and hypothermia after a standard 30 min irradiation. The results obtained on 933 rodents allow to conclude that: (1) there is no interaction between microwaves and the studied convulsants and stimulants; (2) there is a possibility of potentialization of the behavioral effects of a tranquilizer; (3) there is a thermogenic effect of microwaves; (4) there is no change of the blood-brain barrier permeability. The demonstration of a thermal effect of microwaves during radiations lower than 10 mW.cm/sup -2/ the safety threshold admitted presently (a value below which the exposure duration comes under regulation) could explain the energetic nature of certain effects of microwaves up-to-now described as non-thermal.

1982-01-01

266

A versatile and potentially general approach to the targeting of specific cell types by retroviruses: Application to the infection of human cells by means of major histocompatibility complex class I and class II antigens by mouse ecotropic murine leukemia virus-derived viruses  

Energy Technology Data Exchange (ETDEWEB)

A technique for delivering genes carried by recombinant retroviruses into specific cell types could have numerous applications in oncology, developmental biology, and gene therapy. As a first step toward this remote goal the authors designed a procedure allowing in vitro cell targeting by retroviruses. Biotinylated antibodies against the viral envelope protein on one side, and against specific cell membrane markers on the other side, were bridged by streptavidin and used to link the virus to the host. The method was successfully used to infect human cells with ecotropic murine retroviruses by means of major histocompatibility complex class I and class II antigens and appears easily adaptable to other cell, membrane markers. Moreover, the sequential protocol they design, although allowing infection of human cells, requires less stringent safety constraints than would handling of amphotropic virus stocks.

1989-12-01

267

Testing the larval drift hypothesis in the Baltic Sea: retention versus dispersion caused by wind-driven circulation  

DEFF Research Database (Denmark)

Retention or dispersion of larvae from the spawning grounds has been identified as one of the key processes influencing recruitment success in fish stocks. To examine the potential effects of transport on recruitment. numerical simulations were performed utilizing a three-dimensional physical oceanographic model of the Baltic Sea. Cod larvae were represented as Lagrangian drifters released in the deepwater region of the Bornholm Basin, the main spawning ground for Baltic cod. Simulations were performed for the major spawning seasons of 1993 and 1994. when annual and interannual variability of meteorological forcing was large. The principal goals of the modelling exercise were first to identify the physical processes influencing the demersal distribution of the early life stages and second to describe the transport of the pelagic stages in response to variations in windstress, thereby identifying the ...

2001-01-01

268

Environmental, health, and safety issues of sodium-sulfur batteries for electric and hybrid vehicles. Volume 1, Cell and battery safety  

Energy Technology Data Exchange (ETDEWEB)

This report is the first of four volumes that identify and assess the environmental, health, and safety issues involved in using sodium-sulfur (Na/S) battery technology as the energy source in electric and hybrid vehicles that may affect the commercialization of Na/S batteries. This and the other reports on recycling, shipping, and vehicle safety are intended to help the Electric and Hybrid Propulsion Division of the Office of Transportation Technologies in the US Department of Energy (DOE/EHP) determine the direction of its research, development, and demonstration (RD&D) program for Na/S battery technology. The reports review the status of Na/S battery RD&D and identify potential hazards and risks that may require additional research or that may affect the design and use of Na/S batteries. This volume covers cell design and engineering as the basis of safety for Na/S batteries and describes and assesses the ...

1992-09-01

269

Environmental, health, and safety issues of sodium-sulfur batteries for electric and hybrid vehicles  

Energy Technology Data Exchange (ETDEWEB)

This report is the first of four volumes that identify and assess the environmental, health, and safety issues involved in using sodium-sulfur (Na/S) battery technology as the energy source in electric and hybrid vehicles that may affect the commercialization of Na/S batteries. This and the other reports on recycling, shipping, and vehicle safety are intended to help the Electric and Hybrid Propulsion Division of the Office of Transportation Technologies in the US Department of Energy (DOE/EHP) determine the direction of its research, development, and demonstration (RD D) program for Na/S battery technology. The reports review the status of Na/S battery RD D and identify potential hazards and risks that may require additional research or that may affect the design and use of Na/S batteries. This volume covers cell design and engineering as the basis of safety for Na/S batteries and describes and assesses the ...

1992-09-01

270

Joint thesaurus Part I (A-L) + II (M-Z)  

International Nuclear Information System (INIS)

This is the second revision of the ETDE/INIS Joint Thesaurus, including all updates up to September 2006. It contains 21 147 valid descriptors and 9 114 forbidden terms. The Joint Thesaurus contains the controlled terminology for indexing all information within the subject scopes of the International Nuclear Information System (INIS) and the Energy Technology Data Exchange (ETDE). The terminology is intended for use in subject descriptions for input or retrieval of information in these systems. The thesaurus is a terminological control device used in translating from the natural language of documents, indexers or users into a more constrained system language It is also a controlled and dynamic vocabulary of semantically and generically related terms which covers a specific domain of knowledge. The basic terminology in this thesaurus goes back to the 1969 edition of the EURATOM Thesaurus. The structure subsequently given to that terminology was the result of a systematic study performed ...

2005-09-01

271

Breckinridge Project, initial effort. Report VII, Volume III. Cultural resource assessment socioeconomic background data  

Science.gov (United States)

This report has been prepared in conjunction with an environmental baseline study for a commercial coal conversion facility being conducted by Ashland Synthetic Fuels, Inc. (ASFI) and Airco Energy Company (AECO). This report represents a cultural resource assessment for the proposed plant site and two potential solid waste disposal areas. This assessment presents data collected by Dames and Moore during a recent archaeological reconnaissance of the unsurveyed southeastern portion of the proposed plant site and two potential solid waste disposal areas. Also, results of two previous surveys on the northern and southwestern portion of the plant site for American Smelting and Refining Company (ASARCO) and Kentucky Utilities are included. The Dames and Moore survey of the southeastern portion of the plant site identified one archaeological site, three standing structures and one historic cemetery. In addition 47 archaeological ...

272

Working paper on candidate mining sites for surface mining of western oil shales  

Energy Technology Data Exchange (ETDEWEB)

This report describes the selection of candidate surface mining sites for the development of oil shale resources in the western United States. The purpose of this study is to input the various scenarios into an economic mine model developed for underground oil shale mines in an earlier project. Site selection was a three-phase effort. Phase I consisted of a thorough review of available resource data, which resulted in a definition of surface mineable areas. Phase II was a detailed investigation of the regions identified in the initial phase. The end result of this task was a list of potential sites having favorable overburden, grade, shale thickness, and topography values. Phase III identified those sites from which a wide range of site specific parameters can be obtained for mine design and model testing purposes. This report describes the procedures used to obtain the candidate mining scenarios. Section 2.0 discusses the ...

1981-09-02

273

Salt repository project closeout status report  

Energy Technology Data Exchange (ETDEWEB)

This report provides an overview of the scope and status of the US Department of Energy (DOE`s) Salt Repository Project (SRP) at the time when the project was terminated by the Nuclear Waste Policy Amendments Act of 1987. The report reviews the 10-year program of siting a geologic repository for high-level nuclear waste in rock salt formations. Its purpose is to aid persons interested in the information developed during the course of this effort. Each area is briefly described and the major items of information are noted. This report, the three salt Environmental Assessments, and the Site Characterization Plan are the suggested starting points for any search of the literature and information developed by the program participants. Prior to termination, DOE was preparing to characterize three candidate sites for the first mined geologic repository for the permanent disposal of high-level nuclear waste. The sites were in Nevada, a site in volcanic tuff; Texas, a site in bedded salt ...

1988-06-01

274

Promise and Possibility in Special Education Services for Students with Emotional or Behavioral Disorders: Peacock Hill Revisited  

Science.gov (United States)

This article provides an historical look at how programs and practices for students with emotional or behavior disorders (E/BD) have been evaluated since 1964, leading to a codified, although not universally recognized, set of recommendations for evaluating best practices for students with E/BD set out by The Peacock Hill Working Group (1991). The authors contend that, in addition to the programmatic features of best practice, the addition of the quality indicators and standards for research in special education add a critical dimension for examining the quality of the scientific research of identified best practices. Taken together, these set of recommendations and quality indicators represent the state of the art in program evaluation for best practice and programs for students with E/BD. The goal of this article is to outline the current recommendations and apply them to current behavior intervention practices to identify how well the field ...

2010-08-01

275

Energy policy in Taiwan: historical developments, current status and potential improvements  

International Nuclear Information System (INIS)

Recognizing the importance of energy as a vital component in economic development, the Taiwanese government has been continuously revising its energy policy, seeking to balance economic development, energy supply, and environmental protection (3E). Some measures, in an attempt to achieve the 3E balance, were previously implemented in Taiwan; nevertheless, some unresolved issues departing from certain core principles of Taiwan's sustainable energy policy and an international initiative for a low carbon society remain. The aim of this paper is to examine the energy supply and demand structure of Taiwan and the present status of individual energy carriers (including coal, petroleum, natural gas and electricity). In addition, it investigates the current energy policy framework and its implementation in Taiwan, identifies unresolved issues regarding sustainable energy development, and formulates key policy solutions for certain identifiable problems ...

276

Effects of sediment quality on macroinvertebrates in the Sunraysia region of the Murray-Darling Rivers, Australia  

International Nuclear Information System (INIS)

A field-based microcosm approach was tested to identify deterioration of sediment quality in waterways using freshwater macroinvertebrates. The method can potentially identify the nature of contaminants based on species-specific responses. Sediments were collected from the Murray and Darling Rivers and irrigation drains within the Sunraysia region of south-eastern Australia and compared to non-polluted reference sediment. Clean sediments were also spiked with fertiliser to test whether nutrients affected the aquatic fauna. Seven of the eight sediments from the Sunraysia region had a negative impact on the macroinvertebrates, in particular sediment from the Darling River, which supported an impoverished fauna. Three species of chironomid showed varied responses to sediment quality and, although it was hypothesised that nutrients may have impacted on the macroinvertebrate fauna, the results suggest that other pollutants are ...

2008-12-01

277

Chromosome mapping of human CDC25A and CDC25B phosphatases  

Energy Technology Data Exchange (ETDEWEB)

The human CDC25 tyrosine phosphatases trigger activation of CDC2 by removing inhibitory phosphates; thus the genes encoding these phosphatases may be suspected as potential oncogenes due to their role in promoting cell division. To date, three human CDC25 genes have been identified: CDC25A, B, and C. This communication describes the mapping of CDC25A to chromosome 3p21 and CDC25B to chromosome 20p13 by fluorescence in situ hybridization with confirmation by the polymerase chain reaction of hamster-human somatic cell hybrid DNA. 3p21 is near an area frequently involved in karyotypic abnormalities in renal carcinomas, small cell carcinomas of the lung, and benign tumors of the salivary gland. 20p13 does not seem to be a common area for karyotypic alteration in tumors. Mapping of these genes to their chromosomal loci may help identify tumors with abnormal regulation of CDC25 genes due to genomic alterations. 15 refs., 3 figs.

1993-10-01

278

Tracheal compression by mediastinal masses in children: CT evaluation  

Energy Technology Data Exchange (ETDEWEB)

Chest computed tomography (CT) was valuable in detecting extrinsic tracheal compression by mediastinal masses in two pediatric patients. This prompted an independent evaluation by CT of 14 children with masses involving the middle mediastinum and possible intrathoracic tracheal narrowing. Computer programs permit precise calculation of tracheal cross-sectional areas. Any apparent decrease in tracheal area may be compared with CT-derived data in normal children. Chest CT not only demonstrates the presence of extrinsic airway compression in pediatric patients with mediastinal masses, but also is capable of precisely measuring the extent of this narrowing. This method identifies children at potential risk for respiratory compromise and may aid in subsequent therapy.

1983-10-01

279

Toward a hybrid data mining model for customer retention  

British Library Electronic Table of Contents (United Kingdom)

The prevention of subscriber churn through customer retention is a core issue of Customer Relationship Management (CRM). By minimizing customer churn a company maximizes its profit. This paper proposes a hybridized architecture to deal with customer retention problems. It does so not only through predicting churn probability but also by proposing retention policies. The architecture works in two modes: learning and usage.In the learning mode, the churn model learner seeks potential associations from the subscriber database. This historical information is used to form a churn model. This mode also calls for a policy model constructor to use the attributes identified in the churn model to divide all `churners' into distinct groups. The policy model constructor is also responsible for develop...

2007-01-01

280

Targeting the kynurenine pathway as a potential strategy to prevent and treat Alzheimer's disease  

British Library Electronic Table of Contents (United Kingdom)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly accounting for the vast majority of dementia. Recently, many studies have implicated the role of inflammatory response, especially neuroinflammatory response in the development and progression of AD. However, the underlying mechanism of how inflammatory response induces AD is unknown. Kynurenine pathway is a major route of the amino acid tryptophan catabolism, resulting in the production of nicotine adenine dinucleotide and other neuroactive intermediates: quinolinic acid (QA) and kynurenic acid (KA). QA exerts different toxic effects, including over-activation of N-methyl-d-aspartate (NMDA) receptor and excitotoxicity, synaptic dysfunction and neuronal death. On the other hand, KA is identified as the only...

2011-01-01

281

Status of the surry low power and shutdown PRA  

International Nuclear Information System (INIS)

The Surry low power and shutdown probabilistic risk analysis (PRA) is an ongoing project at Brookhaven National Laboratory (BNL) to identify and quantify potential accident scenarios that may occur in a pressurized water reactor (PWR) during low power and shutdown. It was initiated as a result of various incidents and accidents that have occurred within the United States and overseas. The project involves review and evaluation of PWR experience at shutdown, identification of accident scenarios, determination of methods to mitigate the accidents, and performance a level 1 PRA. An evaluation of accident progression, source terms and consequences has also been initiated. The results will be used to address issues related to shutdown conditions. The objective of this paper is to provide a progress report on the project, and to present the approach used as well as the preliminary results of the ongoing and completed tasks.

1991-04-01

282

Stabilization of geothermal residues by encapsulation in portland cement-based composites  

Energy Technology Data Exchange (ETDEWEB)

Presented are the results from a laboratory test program conducted to identify and evaluate materials for converting hazardous geothermal residues to a non-hazardous and potentially usable form. Results indicate that the residues can be effectively incorporated, as a fine aggregate, into portland cement-based composites. Five geothermal residues obtained from sites in the Salton Sea area of California were evaluated. Three of these were classified as hazardous. After mixing with cement, the leach rates were all well below specified levels. Although structural-grade composites were produced, gradual reductions in properties with time up to 1 yr were noted. This indicates ongoing chemical reactions between the cement paste and the constituents of the residues. Further research is necessary before the composites could be considered for use in structural applications. 3 refs., 8 tabs.

1988-05-01

283

Spatio-temporal variability of precipitation, temperature and agricultural drought indices in Central Italy  

British Library Electronic Table of Contents (United Kingdom)

The agricultural sector is probably the one that will suffer most directly from the climatic variations expected at the global level. In particular, the analysis of the changes expected in water availability and demand is fundamental in order to correctly establish both the present water resource management and the definition of new strategies. In this paper the time series of some climatic and agro-climatic indices in the Region of Umbria (Central Italy) have been analyzed with the aim of finding signs of climate changes and identifying the potential impacts on the agricultural water balance. The aforesaid indices include the precipitation, the mean maximum and minimum temperatures (Tmin, Tmax), the mean temperature range (DT), the reference evapotranspiration (ET0) and two drought indice...

2011-01-01

284

Soluble starch?based biodegradable and microporous microspheres as potential adsorbent for stabilization and controlled release of coix seed oil  

British Library Electronic Table of Contents (United Kingdom)

Soluble starch?based biodegradable and microporous microspheres (SDM-Ms) were prepared by emulsion chemical cross-linking technique using trisodium trimetaphosphate (TSTP) as the cross-linker. The resultant amorphous SDM-Ms were excellently identified by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). The internal rupture and surface-controlled erosion were the predominant degradation mechanisms for SDM-Ms. The obtained SDM-Ms were applied to adsorb coix seed oil (CSO) by immersing method. The adsorption capacity of CSO within SDM-Ms was determined, namely 0.5238?g/g, and the thermal stability was shown higher than that of the free CSO. A burst release appeared in the second hour, followed by controlled release. Diffusion, d...

2011-01-01

285

Serotonin Inhibits Protein Feeding in the Blow Fly, Phormia regina (Meigen)  

British Library Electronic Table of Contents (United Kingdom)

Serotonin is an important signaling molecule involved in the control of feeding in flies and other animals. In this study, a potential neurohemal release site for serotonin and the effects of exogenous serotonin on protein feeding were examined in the black blow fly, Phormia regina. A dense network of varicose neural processes exhibiting serotonin-like immunoreactivity was identified on the dorsal region of the thoracico-abdominal ganglion in P. regina. This dorsal region of the central nervous system is a likely site for the release of serotonin into the hemolymph. Circulating serotonin may have multiple systemic effects on fly physiology, including modulating or regulating feeding related processes and diuresis. Injections of exogenous serotonin reduced protein meal size in female flies ...

2009-01-01

286

Selection of IFE target materials from a safety and environmental perspective  

International Nuclear Information System (INIS)

Target materials for inertial fusion energy (IFE) power plant designs might be selected for a wide variety of reasons including wall absorption of driver energy, material opacity, cost and ease of fabrication. While each of these issues are of great importance, target materials should also be selected based upon their safety and environmental (S and E) characteristics. The present work focuses on the recycling, waste management and accident dose characteristics of potential target materials. If target materials are recycled so that the quantity is small, isotopic separation may be economically viable. Therefore, calculations have been completed for all stable isotopes for all elements from lithium to polonium. The results of these calculations are used to identify specific isotopes and elements that are most likely to be offensive as well as those most likely to be acceptable in terms of their S and E characteristics.

2001-05-21

287

Seasonal and habitat abundance and distribution of some forensically important blow flies (Diptera: Calliphoridae) in Central California  

British Library Electronic Table of Contents (United Kingdom)

Seasonal and habitat calliphorid abundance and distribution were examined weekly for two years (2001-2003) in Santa Clara County, California, using sentinel traps baited with bovine liver. Of the 34,389 flies examined in three defined habitats (rural, urban, and riparian), 38% of the total catch represented Compsomyiops callipes (Bigot) and 23% represented Phormia regina (Meigen). Other flies collected in this survey included Calliphora vomitoria (Linnaeus), Calliphora latifrons (Hough), Lucilia sericata (Meigen), Lucilia cuprina (Wiedemann), and Lucilia mexicana (Macquart), which is a new record for the area. Multivariate MANOVA and ANOVA (P 0.05) analysis indicate significant seasonal habitat preference for all fly species examined. This information may be used to identify potentially fo...

2011-01-01

288

Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice  

British Library Electronic Table of Contents (United Kingdom)

Purpose PR-104, a bioreductive prodrug in clinical trial, is a phosphate ester which is rapidly metabolized to the corresponding alcohol PR-104A. This dinitrobenzamide mustard is activated by reduction to hydroxylamine (PR-104H) and amine (PR-104M) metabolites selectively in hypoxic cells, and also independently of hypoxia by aldo-keto reductase (AKR) 1C3 in some tumors. Here, we evaluate reductive metabolism of PR-104A in mice and its significance for host toxicity. Methods The pharmacokinetics of PR-104, PR-104A and its reduced metabolites were investigated in plasma and tissues of mice (with and without SiHa or H460 tumor xenografts) and effects of potential oxidoreductase inhibitors were evaluated. Results Pharmacokinetic studies identified extensive non-tumor reduction of PR-104A to t...

2011-01-01

289

Recognizing limitations in eddy current testing  

International Nuclear Information System (INIS)

This paper addresses known limitations and constraints in eddy current nondestructive testing. Incomplete appreciation for eddy current limitations is believed to have contributed to both under-utilization and misapplication of the technique. Neither situation need arise if known limitations are recognized. Some, such as the skin depth effect, are inherent to electromagnetic test methods and define the role of eddy current testing. Others can be overcome with available technology such as surface probes to find circumferential cracks in tubes and magnetic saturation of ferromagnetic alloys to eliminate permeability effects. The variables responsible for limitations in eddy current testing are discussed and where alternative approaches exist, these are presented. Areas with potential for further research and development are also identified.

1993-11-01

290

Promoting medical tourism to India: Messages, images, and the marketing of international patient travel  

British Library Electronic Table of Contents (United Kingdom)

The practice of medical tourism depends on successfully informing potential patients about procedure options, treatment facilities, tourism opportunities, travel arrangements, and destination countries. The promotion of medical tourism includes a wide range of marketing materials such as flyers, booklets, and websites. Yet, there is a paucity of knowledge about the dissemination, content, and reception of these promotional materials. Drawing on a thematic content analysis of the promotional print material distributed at the first medical tourism trade show in Canada in 2009, the main purpose of this article is to identify and understand the messages and images that companies use to market India as a global destination. While researchers and news media frequently cite low cost procedures as...

2011-01-01

291

Production of {sup 62}Zn, {sup 65}Zn and {sup 203}Pb radioisotopes for studying the transport of zinc and lead in plants  

Energy Technology Data Exchange (ETDEWEB)

In the Carpathian Basin, significant percentage of watershed area and floodplains of rivers are utilised agriculturally. Several potential sources of poisonous metal pollution have been identified in these areas. Because of spills from some of them a few severe accidents have happened especially in the watershed area of Tisza River during the last decades. The motivation of our present work was to produce {sup 62,65}Zn and {sup 203}Pb radioisotopes because they can be used especially as tracers for studying the kinetics of uptake, transport and accumulation of zinc and lead by plants under different circumstances. (orig.)

2004-07-01

292

Production of "6"2Zn, "6"5Zn and "2"0"3Pb radioisotopes for studying the transport of zinc and lead in plants  

International Nuclear Information System (INIS)

In the Carpathian Basin, significant percentage of watershed area and floodplains of rivers are utilised agriculturally. Several potential sources of poisonous metal pollution have been identified in these areas. Because of spills from some of them a few severe accidents have happened especially in the watershed area of Tisza River during the last decades. The motivation of our present work was to produce "6"2","6"5Zn and "2"0"3Pb radioisotopes because they can be used especially as tracers for studying the kinetics of uptake, transport and accumulation of zinc and lead by plants under different circumstances. (orig.)

293

PROSPECTS AND STATUS OF LOW-ASPECT-RATIO TOKAMAKS  

Energy Technology Data Exchange (ETDEWEB)

The prospects for the low-aspect-ratio (A) tokamak to fulfill the requirements of viable fusion power plants are considered relative to the present status in data and modeling. Desirable physics and design features for an attractive Blanket Test Facility and power reactors are estimated for low-A tokamaks based on calculations improved with the latest data from small pioneering experiments. While these experiments have confirmed some of the recent predictions for low-A, they also identify the remaining issues that require verification before reliable projections can be made for these deuterium-tritium applications. The results show that the low-A regime of small size, modest field, and high current offers a path complementary to the standard and high A tokamaks in developing the full potential of fusion power.

1995-01-01

294

PROBING NEAR-SURFACE ATMOSPHERIC TURBULENCE WITH LIDAR MEASUREMENTS AND HIGH-RESOLUTION HYDRODYNAMIC MODELS  

Energy Technology Data Exchange (ETDEWEB)

As lidar technology is able to provide fast data collection at a resolution of meters in an atmospheric volume, it is imperative to promote a modeling counterpart of the lidar capability. This paper describes an integrated capability based on data from a scanning water vapor lidar and a high-resolution hydrodynamic model (HIGRAD) equipped with a visualization routine (VIEWER) that simulates the lidar scanning. The purpose is to better understand the spatial and temporal representativeness of the lidar measurements and, in turn, to extend their utility in studying turbulence fields in the atmospheric boundary layer. Raman lidar water vapor data collected over the Pacific warm pool and the simulations with the HIGRAD code are used for identifying the underlying physics and potential aliasing effects of spatially resolved lidar measurements. This capability also helps improve the trade-off between spatial-temporal resolution and coverage of the ...

2000-11-01

295

Oxidation/sulfidation of material candidates for distributed solar receiver thermochemical transport program in SO/sub 2//O/sub 2/  

Energy Technology Data Exchange (ETDEWEB)

Metals for potential use in the dissociator and the synthesizer reactors of a distributed solar receiver thermochemical transport loop utilizing SO/sub 3//SO/sub 2//O/sub 2/ molecular chemistry were tested in SO/sub 2//O/sub 2/ mixtures at 500/sup 0/C and 900/sup 0/C, respectively, for times of up to four weeks. They included titanium, aluminum and nickel, and iron-base, nickel-base and cobalt-base superalloys. Weight gain measurements determine the oxidation/sulfidation kinetics. Electron microprobe analysis identifies any possible penetration of oxygen and sulfur into the metal and the formation of internal oxides and sulfides. The most promising candidates as a result of these tests are the cobalt-base superalloys.

1985-06-01

296

Oral administration of purple passion fruit peel extract attenuates blood pressure in female spontaneously hypertensive rats and humans  

British Library Electronic Table of Contents (United Kingdom)

Hypertension is one of the most important modifiable risk factors for cardiovascular and cerebrovascular diseases. We investigated the potential antihypertensive effect of the purple passion fruit peel (PFP) extract, a mixture of bioflavonoids, phenolic acids, and anthocyanins, in spontaneously hypertensive rats and human. A high-performance liquid chromatography analysis was performed to identify the active ingredients of the PFP extract. In a rat liver toxicity assay, no hepatotoxicity was observed after 9 hours incubation in the presence of PFP extract (20 ?g/mL). The PFP extract also revealed hepatoprotection against chloroform (1 mmol/L)-induced liver injury. In the experimental model, 24 spontaneously hypertensive rats were divided into 3 treatment groups for a period of 8weeks: cont...

2007-01-01

297

Multidate image analysis of forest degradation in equatorial Africa  

Energy Technology Data Exchange (ETDEWEB)

A section of the northern margin of the Guineo-Congolian rain forest of the Central African Republic is studied to determine to what extent deforestation is evolving. Three sites are presented to highlight the diversity in local environmental settings at the northern margin of the closed equatorial rain forest: the contiguous equatorial rain forest, the boundary between the closed rain forest and the grasslands, and a predominantly secondary grassland environment. Proven image processing procedures for determining land cover and vegetation vigor were applied to Landsat MSS data to determine land cover characteristics and identify alterations in land cover that indicate potentially degraded forest environments. Land cover was independently assessed using spectral signatures determined from a statistical clustering routine. The images presented and image analyses contribute insights and information to an ongoing effort to determine more reliable ...

1990-12-01

298

Magnetic refrigeration: the promise and the problems  

Energy Technology Data Exchange (ETDEWEB)

Magnetic refrigeration uses the temperature- and field-dependence of the entropy of some magnetic materials to accomplish cooling. Because of the intrinsically high efficiency of the magnetization and demagnetization process and because of the potential for excellent heat transfer between solids and fluids, magnetic refrigerators promise to have higher efficiency than existing gas-cycle refrigerators. Many ground-based and space-based applications could benefit significantly from the cost savings implied by higher efficiency. Other attributes of these devices are high reliability and low volume and mass per unit cooling power. The development of these refrigerators is underway at several places around the world, including the Los Alamos National Laboratory. The progress to date has been encouraging but some problems have been clearly identified. The arguments for high efficiency and the problems that will need to be solved to achieve this goal ...

1984-01-01

299

Large (≥2cm) non-hypervascular nodules depicted on MRI in the cirrhotic liver: fate and implications  

British Library Electronic Table of Contents (United Kingdom)

Aim To determine the fate and clinical implication of large (?2cm), non-hypervascular nodules depicted on magnetic resonance imaging (MRI) in the cirrhotic liver. Materials and methods In 21 patients with cirrhosis (14 hepatitis B, two ethanol abuse, four cryptogenic, one Wilson's disease), 25 large (?2cm in the longest dimension) non-hypervascular nodules were identified on dynamic MRI. The implications for diagnosis of the initial size, contour, and signal characteristics on MRI in addition to patients' age and cause of cirrhosis were assessed in our analysis. Results Twelve (75%) out of 16 lesions were malignant or potentially-malignant from 14 hepatitis B patients, while seven (78%) of the nine lesions from other patients were benign (p=0.016). The mean age of the patients who ha...

2008-01-01

300

Influence of shape on ordering of granular systems in two dimensions  

Energy Technology Data Exchange (ETDEWEB)

We investigate ordering properties of two-dimensional granular materials using several shapes created by welding ball bearings together. Ordered domains form much more easily in two than in three dimensions, even when configurations lack long-range order. The onset of ordered domains occurs near a packing density of 0.8, a phenomenon observed previously for disks. One of our shapes, the trapezoid, has packings that remain disordered and near the transition density even after annealing by shaking. Although random packings are unstable for disks and many other shapes in two dimensions, trapezoid packings provide an approach to studying two-dimensional randomness. We also find that the rotational symmetry of a shape is an excellent predictor of how easily it orders, and a potential guide to identifying two-dimensional shapes that remain random after annealing.

2001-06-01

301

Impact of Invasive Cane Toads on Australian Birds  

British Library Electronic Table of Contents (United Kingdom)

Abstract: The cane toad (Bufo marinus), a large, toxic, American anuran, was introduced to Australia in 1935. Populations of many of Australia's reptiles (snakes, varanid lizards, crocodiles) and carnivorous mammals (dasyurid marsupials) have declined because these predators are killed by the toad's powerful toxins. In contrast to these well-studied species, little is known about the cane toads impacts on Australian birds. We reviewed published and unpublished data on behavioral interactions between Australian avian predators and cane toads and collated distributional and dietary information to identify avian taxa potentially at risk from cane toad invasion. Cane toads are sympatric with 172 frog-eating bird species in Australia, and an additional 8 bird species overlap with the predicted ...

2009-01-01

302

Google Android: A State-of-the-Art Review of Security Mechanisms  

CERN Document Server

Google's Android is a comprehensive software framework for mobile communication devices (i.e., smartphones, PDAs). The Android framework includes an operating system, middleware and a set of key applications. The incorporation of integrated access services to the Internet on such mobile devices, however, increases their exposure to damages inflicted by various types of malware. This paper provides a comprehensive security assessment of the Android framework and the security mechanisms incorporated into it. A methodological qualitative risk analysis that we conducted identifies the high-risk threats to the framework and any potential danger to information or to the system resulting from vulnerabilities that have been uncovered and exploited. Our review of current academic and commercial solutions in the area of smartphone security yields a list of applied and recommended defense mechanisms for hardening mobile devices in general and the Android ...

2009-01-01

303

Gene expression analysis identifies potential biomarkers of phenanthrene in human hepatocytes (HepG2)  

British Library Electronic Table of Contents (United Kingdom)

Polycyclic aromatic hydrocarbons (PAHs) are ubiquious in the environment both as natural products and as environmental contaminants. Among PAHs, phenanthrene (PH) that is ubiquitously distributed throughout the environment was subjected in this study. Although environmental distribution and metabolism of PH have been well reported, there are only a few studies examined the expression of mRNA and their functions on PH-induced toxicity. A new paradigm in toxicity screening, toxicogenomic technology represents a useful approach for evaluating the toxic properties of environmental pollutants. In this respect, we elicited the genes which were changed more than 2-fold by analysis of gene expression profiles in human hepatocellular carcinoma (HepG2) cells, exposed to PH by using human oligonucleo...

2011-01-01

304

Fractional domain walls from on-site softening in dipolar bosons  

CERN Document Server

We study dipolar bosons in a 1D optical lattice and identify a region in parameter space---strong coupling but relatively weak on-site repulsion---hosting a series of stable CDW states whose low-energy excitations, built from "fractional domain walls", are remarkably similar to those of non-abelian fractional quantum Hall states. Here, a conventional domain wall between translated CDW's may split by inserting strings of degenerate, but inequivalent, CDW states. Outside these insulating regions, we find numerous supersolids as well as a superfluid regime. The mentioned phases should be accessible experimentally, and in particular, the fractional domain walls can be created in the ground state using single-site addressing, i.e. by locally changing the chemical potential.

2011-01-01

305

Fish intake and acute coronary syndrome  

British Library Electronic Table of Contents (United Kingdom)

Aims To study the effect of fish consumption on the risk of acute coronary syndrome (ACS) in healthy subjects. Methods and results This Danish follow-up study included 57 053 men and women between 50 and 64 years. Intake of lean and fatty fish was estimated from a detailed and validated food frequency questionnaire. Potential cases of ACS were identified through nationwide medical databases. A total of 1122 cases of ACS were verified during a mean follow-up period of 7.6 years. Among men, intake of fatty fish was associated with a lower risk of ACS. For men in the highest quintile of fish intake compared with the lowest quintile, the hazard ratio was 0.67 (95% confidence interval: 0.53-0.85). The inverse association was observed for intakes >6 g of fatty fish per day with no obvious additi...

2010-01-01

306

Fire and explosion assessment on oil and gas floating production storage offloading (FPSO): An effective screening and comparison tool  

British Library Electronic Table of Contents (United Kingdom)

Fires and explosions have been identified as major potential hazards for Oil and Gas Floating Production Storage Offloading (FPSO) installations and pose risk to personnel, assets, and the environment. Current fire and explosion assessment (FEA) tools require physical effect modeling software and follows standards from API, ISO, and engineering practices. However, the tools are not specific to any particular system such as an FPSO, and do not provide comprehensive guidance for safety engineers to perform FEA. This paper discusses the development of a screening and comparison tool for FEA on FPSOs and the incorporation of an expert system into the tool. The results are computerized using MS Excel/VBA to provide a structured and comprehensive assessment on each equipment and module handling ...

2009-01-01

307

Finite element analysis of a scanning x-ray microscope micropositioning stage  

Energy Technology Data Exchange (ETDEWEB)

A micropositioning stage for use with an x-ray microscope has been developed to scan samples over a 100 {mu}m{times}100-{mu}m area with a resolution of 100 A. The stage employs flexure hinges driven by piezoelectric actuators to achieve this high positioning accuracy. Due to the severe geometry of the hinges, stresses and deflections are determined (via finite element methods) to ensure a credible design. Since the stage is to be used in a stepping capacity, natural frequencies are computed to identify resonant conditions which could potentially cause excessive deflections. The finite element models show that the stage responds like a discrete lumped-mass system for the lower modes, and a continuous system with flexural characteristics for the higher modes.

1992-01-01

308

Explosives sensor  

Energy Technology Data Exchange (ETDEWEB)

A compact and supersensitive device that can rapidly detect minute trace vapors from concealed explosives has been developed by scientists at Oak Ridge National Laboratory (ORNL). The new explosives sensor can detect and chemically identify organic nitrogen-oxygen compounds which are the building blocks of explosives such as TNT, plastiques, and nitroglycerine. The device could be used to scan persons entering airport terminals, nuclear power plants, defense installations, or other sensitive locations, providing greater security against potential terrorism. This device works on a glow discharge principle, and is more specifically called an ''Atmospheric Sampling Glow Discharge Ionization'' (ASGDI) source. The new detector is a highly automated, miniaturized version of research mass spectrometers widely used to trace constituents of chemical mixtures. Detail of this device's construction and ...

1987-01-01

309

Evolution of drought severity and its impact on corn in the Republic of Moldova  

British Library Electronic Table of Contents (United Kingdom)

Droughts in Moldova were evaluated using meteorological data since 1955 and a long time series (1891?2009). In addition, yields for corn (Zea mays L.), a crop widely grown in Moldova, were used to demonstrate drought impact. The main aim is to propose use of the S i (S i-a and S i-m) drought index while discussing its potential use in studying the evolution of drought severity in Moldova. Also, a new multi-scalar drought index, the standardized precipitation?evapotranspiration index (SPEI), is tested for the first time in identifying drought variability in Moldova while comparing it with the commonly used standardized precipitation index (SPI). S i-m, SPI, SPEI, and S i-a indices show an increasing tendency toward more intensive and prolonged severely dry and extremely dry summer months. D...

2011-01-01

310

Evaluation of the Influence That Was Produced by Phytoremediation of Soil Microorganisms at Oil Showings  

Science.gov (United States)

Phytoremediation has been identified as a potentially environmentally friendly and cost effective technique for the treatment of contaminated soil. However, phytoremediation has an unknown mechanism. In this study, we focus on the effects of the cultivation of Italian ryegrass on the soil microbes collected at oil showings, which were expected to have a variety of crude oil degradable microorganisms. We evaluated the number of crude oil degradable microorganism, microbial activity, microflora using the PCR-DGGE method and the change in the concentration of crude oil in the soil. The results indicated that the microflora was affected by the cultivation of Itarian ryegrass, and that the microbial activity and the number of crude oil degradable microorganisms were also improved by the cultivation. Moreover, the concentration of crude oil in the rhizosphere soil decreased significantly when compared to the uncultivated soil. These results suggested ...

2009-01-01

311

Evaluation of potential severe accidents during low power and shutdown operations at Surry: Unit 1, Volume 1  

International Nuclear Information System (INIS)

This document contains a summarization of the results and insights from the Level 1 accident sequence analyses of internally initiated events, internally initiated fire and flood events, seismically initiated events, and the Level 2/3 risk analysis of internally initiated events (excluding fire and flood) for Surry, Unit 1. The analysis was confined to mid-loop operation, which can occur during three plant operational states (identified as POSs R6 and R10 during a refueling outage, and POS D6 during drained maintenance). The report summarizes the Level 1 information contained in Volumes 2--5 and the Level 2/3 information contained in Volume 6 of NUREG/CR-6144.

1990-10-22

312

Energetics of the fission process  

Energy Technology Data Exchange (ETDEWEB)

The mass asymmetry of fragments from nuclear fission of heavy nuclei is reviewed. While mass asymmetry is a common and well-known phenomenon for low-energy fission of the lighter actinides, more recent experiments have demonstrated that, for the heaviest actinides, the mass distribution switches to a symmetric one. On the other hand, it has been discovered that, though for fissioning nuclei with mass numbers A< or [approx]225 the mass distribution is basically symmetric, an asymmetric component is clearly to be identified for nuclei down to the Pb-region. In the absence of a generally accepted dynamical theory of fission, the above experimental findings are discussed in terms of static energy considerations. Triggered from the outset by the structure of the potential energy surface at the saddlepoint, the energy balance at the scission point between the available energy (Q-value) of the reaction and the Coulomb and deformation energy of the ...

1994-09-01

313

Energetics of the fission process  

International Nuclear Information System (INIS)

The mass asymmetry of fragments from nuclear fission of heavy nuclei is reviewed. While mass asymmetry is a common and well-known phenomenon for low-energy fission of the lighter actinides, more recent experiments have demonstrated that, for the heaviest actinides, the mass distribution switches to a symmetric one. On the other hand, it has been discovered that, though for fissioning nuclei with mass numbers A< or #approx#225 the mass distribution is basically symmetric, an asymmetric component is clearly to be identified for nuclei down to the Pb-region. In the absence of a generally accepted dynamical theory of fission, the above experimental findings are discussed in terms of static energy considerations. Triggered from the outset by the structure of the potential energy surface at the saddlepoint, the energy balance at the scission point between the available energy (Q-value) of the reaction and the Coulomb and deformation energy of the ...

314

Earliest art in the Americas: incised image of a proboscidean on a mineralized extinct animal bone from Vero Beach, Florida  

British Library Electronic Table of Contents (United Kingdom)

A fragmented fossil bone incised with the figure of a proboscidean was recently found at Vero Beach, Florida near the location where Late Pleistocene fauna and human bones were recovered from 1913 to 1916. This engraving may represent the oldest and only existing example of Terminal Pleistocene art depicting a proboscidean in the Americas. Because of the uniqueness, rarity, and potential antiquity of this specimen, caution demanded that a variety of tests be used in an attempt to verify its authenticity. The mineralized bone was identified as mammoth, mastodon, or giant sloth. Rare earth element analysis was consistent with the fossil bone being ancient and originating at or near the Old Vero site (8-IR-9). Forensic analysis suggests the markings on the bone are not recent. Optical microsc...

2011-01-01

315

Drivers of Transfusion Decision Making and Quality of the Evidence in Orthopedic Surgery: A Systematic Review of the Literature  

British Library Electronic Table of Contents (United Kingdom)

Reasons for variation in transfusion practice in orthopedic surgery are not well understood. This systematic review identified and appraised the quality of the literature in this area to assess the impact of factors associated with the use of allogeneic red blood cell (RBC) transfusion in orthopedic procedures. MEDLINE and EMBASE databases were searched for relevant English language publications. Articles containing a range of MeSH and text terms regarding ''blood transfusion,'' ''predictors,'' and ''multiple logistic regression'' were retrieved. Articles that focused on patients undergoing orthopedic procedures and that met prespecified inclusion criteria were appraised in terms of potential bias and the appropriateness of statistical approach. A total of 3641 citations were retrieved, an...

2011-01-01

316

Darrieus vertical axis wind turbine program overview  

Science.gov (United States)

As a US Department of Energy (DOE) laboratory, Sandia Laboratories is developing Darrieus vertical axis wind turbine (VAWT) technology with the objective of encouraging private industry to produce economically feasible, commercially marketable wind energy systems. The first full cycle of development is essentially complete, and resulting current technology designs have been evaluated for cost-effectiveness. Aerodynamic, structural, and system analyses capabilities have evolved during this cycle to support and evaluate the system designs. This report presents some of the more salient recent developments, first generation costs, current activities, and future plans. Potential design improvements identified in the first development cycle are presented along with their cost benefits.

317

Compact Single-Stage Fuel Processor for PEM Fuel Cells. Final report  

Energy Technology Data Exchange (ETDEWEB)

Based on observations during the steam reforming of ethanol, the authors conclude that carbon was forming in the steam generator due to the thermal decomposition of ethanol. Since ethanol is being thermally decomposed, they were operating the steam generator at too high of a temperature. The thermal degradation of ethanol was confirmed by using a GC with a flame ionization detector. They observed trace amounts of additional hydrocarbons other than methane in the effluent which we assume maybe ethane and ethylene. We identified the operating conditions that allowed us to steam reform ethanol for an acceptable amount of time. These conditions were a steam temperature of 200 C and a wall temperature of 400 C at the center of the reactor. The calculated ratios of CO{sub 2}/CO indicate that we can lower the potential for carbon deposition from the Boudouard further by reducing the pressure.

2000-01-01

318

Climatic change and river ice breakup  

Energy Technology Data Exchange (ETDEWEB)

An overview of climatic factors and impact relative to river ice engineering and science is presented. An explanation of the fundamentals of climatic change is followed by a review of direct and indirect climatic influences that govern river ice breakup and related trends. Known responses of river ice to climatic change and potential future changes to ice breakup processes are described along with the probable ecological and socio-economic consequences of these changes. Changes in engineering approaches to accommodate the present ice regime and predicted changes in climatic variables that affect river ice processes and reduce the vulnerability of infrastructure and ecosystems to climatic change are examined. Future research on the links between river ice and stream ecology is suggested to identify ecological concerns that may result from changes in river ice regimes induced by climatic change. 60 refs., 3 figs.

2003-07-01

319

Climate change and the African baobab (Adansonia digitata L.): the need for better conservation strategies  

British Library Electronic Table of Contents (United Kingdom)

Abstract The baobab tree, with more than 300 uses and commercial value in EU and United States, has been identified as one of the most important trees to be conserved and domesticated in Africa. A decline in baobab populations because of changes in climate could have a negative effect on African livelihoods. Therefore, it is important to study the potential future distribution of this species and determine strategies for conservation. We used Maxent, 480 geo-referenced records, present and future climatic and soil layers. Different general circulation models and scenarios were selected. Models were simulated for (i) All records, (ii) East Africa and (iii) West Africa species records. For each combination, the proportion of the present habitat that might remain suitable in the future was de...

2011-01-01

320

Bilateral but not Unilateral Testicular Hypotrophy Predicts for Severe Impairment of Semen Quality in Men with Varicocele Undergoing Infertility Evaluation  

British Library Electronic Table of Contents (United Kingdom)

ObjectivesVaricocele is a common cause of infertility, and varicocele-associated testicular hypotrophy has been described as a potential cause of decreased semen quality. We investigated the relationship between testicular hypotrophy and poor semen quality in infertile men with varicoceles. We hypothesized that bilateral hypotrophy is required before the semen quality is severely impaired.MethodsWe retrospectively identified consecutive patients with palpable varicoceles undergoing an infertility evaluation at a single academic center. Each patient was evaluated by the same clinician with history and physical examination. Testicular hypotrophy was defined as a size discrepancy of greater than 3 mL or an absolute size of less than 14 mL. Multivariate logistic regression analysis was used to...

2008-01-01

321

Behind an ambitious megaproject in Asia: The history and implications of the Bakun hydroelectric dam in Borneo  

British Library Electronic Table of Contents (United Kingdom)

Using a case-study, inductive, narrative approach, this article explores the history, drivers, benefits, and barriers to the Bakun Hydroelectric Project in East Malaysia. Situated on the island of Borneo, Bakun Dam is a 204m high concrete face, rock filled dam on the Balui River in the Upper Rajang Basin in the rainforests of Sarawak. Bakun Dam and its affiliated infrastructure could be the single largest and most expensive energy project ever undertaken in Southeast Asia. Based on data collected through site visits, original field research in Sarawak, and more than 80 research interviews, the article begins by teasing out the complex history and drivers behind the Bakun project before identifying a set of potential social, political, and economic benefits the project could deliver. It the...

2011-01-01

322

Base flow hydrology and water quality of an Ozarks spring and associated recharge area, southern Missouri, USA  

British Library Electronic Table of Contents (United Kingdom)

Human activities in the karst Ozark Plateaus can impact water quality of springs where surface water is rapidly transferred to subsurface conduits. Bennett Spring, in southern Missouri, is the fourth largest spring in the state and supports local tourism activities. Questions regarding poorly functioning on-site wastewater systems (OWS) have raised concerns over the long-term water quality of the spring. This study reports the results of a surface water quality monitoring program in the recharge area where monthly samples were collected at base flow to identify potential pollution sources to the spring. Base flow hydrology of the recharge area was highly variable over the study period, which was drier than normal, causing an incomplete sampling record due to no flow conditions at some site...

2011-01-01

323

Assessment, development and coordination of technology base studies in enhanced heat transfer. Quarterly progress report No. 7, March 1, 1983-May 31, 1983  

Energy Technology Data Exchange (ETDEWEB)

The major goal of this continuation project is to advance the utilization of heat transfer enhancement techniques in commercial heat exchange equipment. Thirteen heat transfer enhancement techniques have been identified as having potential for improving heat transfer coefficients in full-scale industrial equipment. The following tasks are part of this project, which was originally planned for three years: (1) expansion of technology information base; (2) evaluation of performance of enhanced surfaces and inserts; (3) correlation of data for spirally fluted surfaces; (4) study of structured surfaces in pool boiling; and (5) study of structured surface in spray film evaporation.

1983-08-01

324

Applications of nanomaterials in environmental protection; Untersuchung des Einsatzes von Nanomaterialien im Umweltschutz  

Energy Technology Data Exchange (ETDEWEB)

Following comprehensive research nanomaterials or products which were either still in a re-search/development status or are already available in the marketplace were identified for the water and air sectors. Based on life cycle assessments for two case studies, it was checked how the potential benefits and impacts on the environment for nanotechnology products or processes compare with those for conventional solutions. The first case study deals with the solar treatment of water contami-nated with tetrachloroethylene, comparing nanoscale titanium dioxide (photo-catalysis) and a photo-Fenton process. The second case study on air filtration compares a passenger car cabin-air filter with nanofibres and a conventional filter. (orig.)

2010-06-15

325

A fast model for estimating work-function modifications induced by organic charge-transfer (Sub)monolayers  

Energy Technology Data Exchange (ETDEWEB)

Calculating work-function modifications for flat-lying conjugated molecules on extended metal surfaces using density functional theory (DFT) is an extremely resource intensive task. This prevents fast screening of new molecules for their potential to optimize metal work functions for good electron or hole injection in organic electronic devices. We present a semi-classical model, which avoids that problem. This is achieved by identifying the dominant processes occurring at the interface between metal and adsorbate in the pinning-regime, which are then parameterizing their description using band-structure DFT calculations for a small training set With the resulting interdependent equations at hand, only simple gas-phase calculations are needed to predict the work-function changes induced by new molecules. The model is tested for ten molecules on three different metal surfaces, where it shows excellent agreement with photoelectron spectroscopy ...

2010-07-01

326

A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp  

British Library Electronic Table of Contents (United Kingdom)

T-2 toxin, a highly toxic member of the type-A trichothecenes, is produced by various Fusarium moulds that can potentially affect human health. It is strongly cytotoxic for human hematopoietic progenitors. Alimentary toxic aleukia (ATA), a disease typically associated with human, is primarily induced by T-2 toxin. A comparison of the metabolism of T-2 toxin incubated with hepatocytes of rats, piglets, chickens, and the hepatic subcellular fractions (microsomes and cytosol) of piglets, chickens, rats, and carp (common carp and grass carp) was carried out. The activities of the recombinant pig CYP3A29 on the transformation of T-2 and HT-2 toxins were preliminary studied. Metabolites were identified by novel LC/MS-IT-TOF. Qualitative similarities and differences across the species were observ...

2011-01-01

327

The strong associations between organism characteristics and network architecture  

CERN Document Server

Understanding the dependence and interplay between architecture and function in biological networks has great relevance to disease progression, biological fabrication and biological systems in general. Recent research in complex systems and networks, presents methods to properly mine the architectural interdependence in networks. Guided by such work, we propose methods to associate organism characteristics with network topology by analyzing a large number of architectural patterns. We adopt an automated approach using 11 topological metrics from complex networks to characterize a collection of various kinds of biological networks. Principal component analysis and clustering allow us to extract the indispensable, independent and informative metrics. Using hierarchical linear modeling, we observe that organism characteristics associate with these metrics, surprisingly well. This work can serve as a ...

2009-01-01

328

Development of a computerized portal verification scheme for pelvic treatment fields  

International Nuclear Information System (INIS)

Purpose/Objective: At present, treatment verification between portal and reference images is performed based on manually-identified features by radiation oncologist, which is both time-consuming and potentially error-prone. There is a demand for the computerized verification procedure in clinical application. The purpose of this study is to develop a computerized portal verification scheme for pelvic treatment fields. Materials/Methods: The automated verification system involves image acquisition, image feature extraction, feature matching between reference and portal images and quantitative evaluation of patient setup. Electronic portal images with a matrix size of 256 x 256 and 12 bit gray levels were acquired using a liquid matrix electronic portal imaging device. Simulation images were acquired by digitizing simulation films using a TV camera into images with 256 x 256 matrix and 8 bit gray levels. Initially a Canny edge detector is applied ...

1996-09-01

329

RCRA Facilities Assessment (RFA)---Oak Ridge National Laboratory  

Energy Technology Data Exchange (ETDEWEB)

US Department of Energy (DOE) facilities are required to be in full compliance with all federal and state regulations. In response to this requirement, the Oak Ridge National Laboratory (ORNL) has established a Remedial Action Program (RAP) to provide comprehensive management of areas where past and current research, development, and waste management activities have resulted in residual contamination of facilities or the environment. This report presents the RCRA Facility Assessment (RFA) required to meet the requirements of RCRA Section 3004(u). Included in the RFA are (1) a listing of all sites identified at ORNL that could be considered sources of releases or potential releases; (2) background information on each of these sites, including location, type, size, period of operation, current operational status, and information on observed or potential releases (as required in Section II.A.1 of the RCRA permit); (3) ...

1987-03-01

330

Preparation and evaluation of radioiodinated 1-(dialkyl-aminoalkyl)-4-phenylpiperazines as potential brain imaging agents  

Energy Technology Data Exchange (ETDEWEB)

The interest in radioiodinated diamines stems from their similarity to /sup 125/I-HIPDM and to the 1-dialkvlamino-acyl-4-phenylpiperazines that the authors have previously examined as potential brain imaging agents. In this study they converted the 1-(dialkylaminoacyl)-4-phenylpiperazines to their corresponding 1-(dialkylaminoacyl) analogs via reduction with diborane in THF. Radioiodination at the no-carrier-added level with Na/sup 125/I and chloramine-T gave the final compounds, after chromatographic separation, in 30-50% yields. The tissue distributions were determined in rats at 0.25, and 4 hrs after an i.v. injection of the radiochemical. The results indicated that all of the agents were readily extracted by the brain (1.5-2.5% ID) with brain to blood ratios >20. The structure-distribution relationships for this series were, however, decidedly different from the aminoacyl compounds in that morpholino-derivatives had better uptake and retention than the ...

1985-05-01

331

Preparation and evaluation of radioiodinated 1-(dialkyl-aminoalkyl)-4-phenylpiperazines as potential brain imaging agents  

International Nuclear Information System (INIS)

The interest in radioiodinated diamines stems from their similarity to /sup 125/I-HIPDM and to the 1-dialkvlamino-acyl-4-phenylpiperazines that the authors have previously examined as potential brain imaging agents. In this study they converted the 1-(dialkylaminoacyl)-4-phenylpiperazines to their corresponding 1-(dialkylaminoacyl) analogs via reduction with diborane in THF. Radioiodination at the no-carrier-added level with Na/sup 125/I and chloramine-T gave the final compounds, after chromatographic separation, in 30-50% yields. The tissue distributions were determined in rats at 0.25, and 4 hrs after an i.v. injection of the radiochemical. The results indicated that all of the agents were readily extracted by the brain (1.5-2.5% ID) with brain to blood ratios >20. The structure-distribution relationships for this series were, however, decidedly different from the aminoacyl compounds in that morpholino-derivatives had better uptake and retention than the ...

1985-06-02

332

Preliminary assessment of condensation behavior for hydrocarbon-vapor expansions which cross the saturation line near the critical point  

Energy Technology Data Exchange (ETDEWEB)

Previous analyses of binary cycles for conversion of geothermal energy from moderate temperature resources to electrical energy have shown potential gains in net geofluid effectiveness on the order of 8%, resulting from selection of turbine-expansion processes whose equilibrium states pass through the two-phase region. If condensation occurs, this gain could be reduced or eliminated by the resulting loss in turbine efficiency. Experience with many fluids, however, indicates that vapor supersaturation permits metastable pure-vapor states to exist at temperatures considerably below the saturation temperature at a given pressure; thus, by better understanding the condensation process, and properly structuring the cycle, substantial performance gains may be possible. The purpose of the present study was to assess the probability for attaining this performance gain by estimating the extent of condensation which might be expected during such an expansion of isobutane ...

1983-01-01

333

Nevada Nuclear Waste Storage Investigations: Exploratory Shaft Facility fluids and materials evaluation  

Energy Technology Data Exchange (ETDEWEB)

The objective of this study was to determine if any fluids or materials used in the Exploratory Shaft Facility (ESF) of Yucca Mountain will make the mountain unsuitable for future construction of a nuclear waste repository. Yucca Mountain, an area on and adjacent to the Nevada Test Site in southern Nevada, USA, is a candidate site for permanent disposal of high-level radioactive waste from commercial nuclear power and defense nuclear activities. To properly characterize Yucca Mountain, it will be necessary to construct an underground test facility, in which in situ site characterization tests can be conducted. The candidate repository horizon at Yucca Mountain, however, could potentially be compromised by fluids and materials used in the site characterization tests. To minimize this possibility, Los Alamos National Laboratory was directed to evaluate the kinds of fluids and materials that will be used and their potential impacts on the site. A ...

1988-11-01

334

Methods and findings of the SNR study  

International Nuclear Information System (INIS)

A featfinding committee of the German Federal Parliament in July 1980 recommended to perform a ''risk-oriented study'' of the SNR-300, the German 300 MW fast breeder prototype reactor being under construction in Kalkar. The main aim of this study was to allow a comparative safety evaluation between the SNR-300 and a modern PWR, thus to prepare a basis for a political decision on the SNR-300. Methods and main results of the study are presented in this paper. In the first step of the risk analysis six groups of accidents have been identified which may initiate core destruction. These groups comprise all conceivable courses, potentially leading to core destruction. By reliability analyses, expected frequency of each group has been calculated. In the accident analysis potential failure modes of the reactor tank have been investigated. Core destruction may be accompanied by the release of significant amounts of mechanical ...

335

Heavy metals in Semarang`s urban streams: Spatial distribution and bioindication using the guppy (Lepistes reticulatus)  

Energy Technology Data Exchange (ETDEWEB)

A field survey on cadmium, lead, copper, and zinc was performed in Semarang, the fifth largest city in Indonesia. Water, sediment, and fish samples were collected from 101 grids of 2 x 2 km. The objectives of the study were (1) to identify the spatial distribution of metals in the sediments of the greater Semarang area, (2) to estimate the background concentrations of the metals present in Semarang, (3) to provide a simple tool for deriving standards for metals in the sediment, and (4) to explore the potential use of the guppy (Lebistes reticulatus) as a bioindicator of urban metal pollution. To map the spatial distribution of the metals, concentrations of each metal in sediment were plotted against the corresponding city coordinate. On the basis of these plots, background concentrations of the metals were estimated. A combined pollution index can be derived thereafter by calculating the difference between metals concentrations from a ...

1996-12-31

336

Estimation of trace elements in some anti-diabetic medicinal plants using PIXE technique  

Energy Technology Data Exchange (ETDEWEB)

Trace elemental analysis was carried out in various parts of some anti-diabetic medicinal plants using PIXE technique. A 3 MeV proton beam was used to excite the samples. The elements Cl, K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Br, Rb and Sr were identified and their concentrations were estimated. The results of the present study provide justification for the usage of these medicinal plants in the treatment of diabetes mellitus (DM) since they are found to contain appreciable amounts of the elements K, Ca, Cr, Mn, Cu, and Zn, which are responsible for potentiating insulin action. Our results show that the analyzed medicinal plants can be considered as potential sources for providing a reasonable amount of the required elements other than diet to the patients of DM. Moreover, these results can be used to set new standards for prescribing the dosage of the herbal drugs prepared from these plant materials.

2006-08-15

337

Anaerobic digestion and related best management practices : utilizing life cycle assessment  

Energy Technology Data Exchange (ETDEWEB)

This paper reported on a life cycle assessment (LCA) study that compared the environmental impacts of business-as-usual manure management with those of a manure management operation incorporating anaerobic digestion with combined heat and power generation. The case study was based on a medium sized dairy farm in northern New York State. The study identified the benefits resulting from the displacement of fossil fuels, and reduction of related emissions. Although anaerobic digestion of dairy manure with energy recovery through biogas combustion is viewed as a positive environmental approach to increase the use of renewable energy, there are potential negative impacts that can counteract the environmental benefits. The negative impacts are associated with emissions of methane and nitrogen species during digestion and after spreading of digester effluent. The environmental impacts and their causes should be evaluated in order to promote best ...

2010-07-01

338

RESTORING SUSTAINABLE FORESTS ON APPALACHIAN MINED LANDS FOR WOOD PRODUCTS, RENEWABLE ENERGY, CARBON SEQUESTRATION, AND OTHER ECOSYSTEM SERVICES  

Energy Technology Data Exchange (ETDEWEB)

The overall purpose of this project is to evaluate the biological and economic feasibility of restoring high-quality forests on mined land, and to measure carbon sequestration and wood production benefits that would be achieved from forest restoration procedures. In this quarterly report, we present a preliminary comparison of the carbon sequestration potential of forests growing on 14 mined sites in a seven-state region in the Midwestern and Eastern Coalfields. Carbon contents of these forests were compared to adjacent forests on non-mined land. The study was installed as a 3 x 3 factorial in a random complete block design with three replications at each location. The treatments include three forest types (white pine, hybrid poplar, mixed hardwood) and three silvicultural regimes (competition control, competition control plus tillage, competition control plus tillage plus fertilization). Each individual treatment plot is 0.5 acres. Each block ...

2004-06-04

339

PhytoPet : a database of plants that play a role in the phytoremediation of petroleum hydrocarbons  

International Nuclear Information System (INIS)

This support document summarized the results of botanical surveys conducted as part of a phytoremediation research project that catalogued plants found growing at a petroleum impacted site in Alberta. Phytoremediation refers to the growing of chosen plant species in a polluted site for a period of time in order for the plant to remove contaminants through its natural attributes of absorption, translocation, storage and excretion. Several different plant species with phytoremediation properties are being considered for wide scale bioremediation use. This document described the PhytoPet database which was originally developed as an inventory of plants with phytoremediation capabilities. It was designed to provide easy access to information and help users choose plants with the potential to phytoremediate petroleum hydrocarbons. The information in this document is intended for remediation specialists, site owners and managers as well as environmental scientists in ...

340

Global changes and the air-sea exchange of chemicals  

International Nuclear Information System (INIS)

Present and potential future changes to the global environment have important implications for marine pollution and for the air-sea exchange of both anthropogenic and natural substances. This report addresses three issues related to the potential impact of global change on the air-sea exchange of chemicals: Global change and the air-sea transfer of the nutrients nitrogen and iron. Global change and the air-sea exchange of gases. Oceanic responses to radiative and oxidative changes in the atmosphere. The deposition of atmospheric anthropogenic nitrogen has probably increased biological productivity in coastal regions along many continental margins. Atmospheric deposition of new nitrogen may also have increased productivity somewhat in mid-ocean regions. The projected future increases of nitrogen oxide emissions from Asia, Africa and South America will provide significant increases in the rate of deposition of oxidized ...

1996-08-01

341

The sensitivity of real-time PCR amplification targeting invasive Salmonella serovars in biological specimens  

UK PubMed Central (United Kingdom)

BackgroundPCR amplification for the detection of pathogens in biological material is generally considered a rapid and informative diagnostic technique. Invasive Salmonella...Full Text Available

342

Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs)  

UK PubMed Central (United Kingdom)

Early on, intriguing biological activities were found associated with the EETs using in vitro systems. Although the EETs other than the 5,6-isomer, are quite stable chemically,...Full Text Available

2007-01-01

343

Reproductive Success of Cavity-nesting Birds Breeding under High-voltage Powerlines  

Science.gov (United States)

... biological effects of electromagnetic fields (EMFs) produced by high-voltage transmission lines have come under intense scrutiny, mostly with respect ... biological effects of electromagnetic fields (EMFs...

344

Preparation and biological properties of a novel composite scaffold of nano-hydroxyapatite/chitosan/carboxymethyl cellulose for bone tissue engineering  

UK PubMed Central (United Kingdom)

In this study, we report the physico-chemical and biological properties of a novel biodegradable composite scaffold made of nano-hydroxyapatite and natural derived polymers of chitosan and carboxymethyl...Full Text Available

345

Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.  

UK PubMed Central (United Kingdom)

Cleavage of membrane-associated proteins with the release of biologically active macromolecules is an emerging theme in biology. However, little is known about the nature and regulation of the involved...Full Text Available

1996-07-23

346

Near Infrared Dyes as Lifetime Solvatochromic Probes for Micropolarity Measurements of Biological Systems  

UK PubMed Central (United Kingdom)

The polarity of biological mediums controls a host of physiological processes such as digestion, signaling, transportation, metabolism, and excretion. With the recent widespread use of near-infrared...Full Text Available

2007-10-15

347

Metabolic clearance of biologically active luteinizing hormone in man.  

UK PubMed Central (United Kingdom)

The plasma metabolic clearance of biologically active luteinizing hormone (bioactive LH) was studied using the rat interstitial cell testosterone (RICT) bioassay in six hypogonadotropic men after single...Full Text Available

1986-04-01

348

Estimation of effective population sizes from data on genetic markers  

UK PubMed Central (United Kingdom)

The effective population size (Ne) is an important parameter in ecology, evolutionary biology and conservation biology. It is, however, notoriously difficult to estimate,...Full Text Available

2005-07-29

349

Electron spin resonance studies of radiation effects in biological materials. An assessment of current and future research  

Energy Technology Data Exchange (ETDEWEB)

Electron spin resonance spectroscopy can provide a powerful approach to the study of radiation effects in biological materials. This memorandum gives an overview of current and future research. (author).

1987-06-01

350

Effects of Collaborative Group Composition and Inquiry Instruction on Reasoning Gains and Achievement in Undergraduate Biology  

UK PubMed Central (United Kingdom)

This study compared the effectiveness of collaborative group composition and instructional method on reasoning gains and achievement in college biology. Based on initial student reasoning ability (i.e.,...Full Text Available

2011-03-01

351

Effects of 3 biologic dressings on healing of cutaneous wounds on the limbs of horses  

UK PubMed Central (United Kingdom)

AbstractThree biologic dressings [split-thickness allogeneic skin (STS)], allogeneic peritoneum (P), and xenogenic porcine small intestinal submucosa (PSIS)] were...Full Text Available

2004-01-01

352

Core Synthesis Facility: Bridging the Gap between Chemistry and Biology  

UK PubMed Central (United Kingdom)

CF-23“The biggest stumbling block for biological sciences turned out to be synthetic organic chemistry” – Elias A. Zerhouni, Former NIH Director in Chemical...Full Text Available

2010-09-01

353

Coordination chemistry and biological activity of 5'-OH modified quinoline-B12 derivatives.  

Science.gov (United States)

The consequences of structural modifications at the 5'-OH ribofuranotide moiety of quinoline modified B12 derivatives are discussed in regard of the coordination chemistry, the electrochemical properties and the biological behaviour of the compound. PMID:21850334

2011-08-18

354

Computational approaches to discovering semantics in molecular biology  

Energy Technology Data Exchange (ETDEWEB)

One of the central questions of molecular biology is the discovery of the semantics of DNA. This discovery relies in a critical way on a variety of expensive computations. In order to solve these computations, both parallel computers and special-purpose hardware play a major role.

1989-07-01

355

C. elegans as a model for stem cell biology  

UK PubMed Central (United Kingdom)

We review the application of C. elegans as a model system to understand key aspects of stem cell biology. The only bona fide stem cells in C. elegans...Full Text Available

2010-05-01

356

Biologically based pesticide dose estimates for children in an agricultural community.  

UK PubMed Central (United Kingdom)

Current pesticide health risk assessments in the United States require the characterization of aggregate exposure and cumulative risk in the setting of food tolerances. Biologic monitoring can aggregate...Full Text Available

2000-06-01

357

Biological species is the only possible form of existence for higher organisms: the evolutionary meaning of sexual reproduction  

UK PubMed Central (United Kingdom)

Consistent holistic view of sexual species as the highest form of biological existence is presented. The Weismann's idea that sex and recombination provide the variation for the natural...Full Text Available

358

BFL: a node and edge betweenness based fast layout algorithm for large scale networks  

UK PubMed Central (United Kingdom)

BackgroundNetwork visualization would serve as a useful first step for analysis. However, current graph layout algorithms for biological pathways are insensitive to biologically...Full Text Available

359

An Undergraduate Course to Bridge the Gap between Textbooks and Scientific Research  

UK PubMed Central (United Kingdom)

This article reports on a one-semester Advanced Cell Biology course that endeavors to bridge the gap between gaining basic textbook knowledge about cell biology and learning to think and work as a researcher....Full Text Available

2011-03-01

360

A Floristic Reconnaissance of Montane Environments in the Foja Mts. of Papua Province, Indonesia  

Science.gov (United States)

... A Rapid Biological Assessment of the Kaijende Highlands, Enga Province, Papua New Guinea. RAP Bulletin of Biological ... A Rapid Biodiversity Assessment of the Kaijende Highlands, Enga Province, Papua New...

361

Genomics - from Neanderthals to high-throughput sequencing  

UK PubMed Central (United Kingdom)

A report on 'The Biology of Genomes' meeting, Cold Spring Harbor, USA, 10-14 May 2006.

2006-01-01

362

Genetic Applications in Avian Conservation  

Science.gov (United States)

... structure along an elevational gradient in Hawaiian honeycreepers reveals contrasting evolutionary responses to avian malaria. BMC Evolutionary Biology 8: ... ...

363

Effect of dietary constituents on the absorption of lead in the human  

International Nuclear Information System (INIS)

... biological effects body burden diet intestinal absorption lead lead 203 man

1983-03-01

364

Development of a motion analysis system using acceleration sensors for tennis and its evaluations  

British Library Electronic Table of Contents (United Kingdom)

The term biological motion is often used by researchers studying the patterns of movement generated by living forms and in sports. We studied a pattern recognition system of motion in sport using biological motion data. Biological motion data are acquired using a 3D motion capture system. However, 3D motion capture systems are very expensive. In this article, a biological motion capture system was built using acceleration sensors. Our proposed system uses the technique of Gaussian fitting and regression analysis. We tested our proposed system in pattern recognition of outdoor tennis and its evaluations.

2011-01-01

366

Biology-Inspired Distributed Consensus in Massively-Deployed Sensor Networks  

Science.gov (United States)

Promises of ubiquitous control of the physical environment by large-scale wireless sensor networks

2005-01-01

367

BIOMAGNETIC RESPONSE OF SIMPLE BIOLOGICAL ...  

Science.gov (United States)

... Examples include magnetic forming tools, magnetic shielding, magnetohydrodynamic propulsion systems, and various magnetic containment ...

1970-01-01

368

Work plan for the remedial investigation/feasibility study-environmental assessment for the Colonie site, Colonie, New York  

Energy Technology Data Exchange (ETDEWEB)

This work plan has been prepared to document the scoping and planning process performed by the US Department of Energy (DOE) to support remedial action activities at the Colonie site. The site is located in eastern New York State in the town of Colonie near the city of Albany. Remedial action of the Colonie site is being planned as part of DOE's Formerly Utilized Sites Remedial Action Program. The DOE is responsible for controlling the release of all radioactive and chemical contaminants from the site. Under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), a remedial investigation/feasibility study (RI/FS) must be prepared to support the decision-making process for evaluating remedial action alternatives. This work plan contains a summary of information known about the site as of January 1988, presents a conceptual site model that identifies potential routes of human exposure to site containments, ...

1990-06-01

369

Study of scalar leptons at the TESLA Photon Collider  

International Nuclear Information System (INIS)

In this thesis, the potential to discover supersymmetric signatures in both e"+e"- and #gamma##gamma# colliders evaluated with a Monte Carlo analysis, is discussed. The analysis was focused on the detection of muons, essentially. First, we study the detection of #mu#"+_R#mu#"-_R in e"-e"+ collisions, whose purpose is the measurement of the #mu#_R mass. It was found that an uncertainty of 0.11 GeV (stat) can be achieved. Under the assumption of the real conditions of the ILC photon collider, a study covering the detection of #mu#"+_R#mu#"-_R and #mu#"+_L#mu#"-_L pairs for #sq root#(s_e_"-_e_"+)=0.5 and 0.6 TeV was performed. According to the simulation, a statistical error for the branching ratios of #mu#"#+-#_L#->##chi#"0_1#mu#"#+-# of 0.98% and #mu#"#+-#_L#->##chi#"0_2#mu#"#+-# of 3.97% can be reached. In order to judge the Monte Carlo results, we have used a technique based on a multidimensional fit to evaluate the impact of the branching ratio measurements ...

370

Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 118: Area 27 Super Kukla Facility, Nevada Test Site, Nevada, Rev. No.: 1  

Energy Technology Data Exchange (ETDEWEB)

This Streamlined Approach for Environmental Restoration (SAFER) plan addresses closure for Corrective Action Unit (CAU) 118, Area 27 Super Kukla Facility, identified in the ''Federal Facility Agreement and Consent Order''. Corrective Action Unit 118 consists of one Corrective Action Site (CAS), 27-41-01, located in Area 27 of the Nevada Test Site. Corrective Action Site 27-41-01 consists of the following four structures: (1) Building 5400A, Reactor High Bay; (2) Building 5400, Reactor Building and access tunnel; (3) Building 5410, Mechanical Building; and (4) Wooden Shed, a.k.a. ''Brock House''. This plan provides the methodology for field activities needed to gather the necessary information for closing the CAS. There is sufficient information and process knowledge from historical documentation and site confirmation data collected in 2005 and 2006 to recommend closure of CAU 118 using the ...

2006-09-01

371

Possible global environmental impacts of solid waste practices  

Energy Technology Data Exchange (ETDEWEB)

Pollutants resulting from the management of solid waste have been shown to affect the air, land, oceans, and waterways. In addition, solid wastes have other, more indirect impacts such as reduction in feedstocks of natural resources, because useful materials are disposed of rather than recycled. The objective of this study is to evaluate solid waste management practices that have negative implications on the global environment and develop recommendations for reducing such impacts. Recommendations identifying needed changes are identified that will reduce global impacts of solid waste practices in the future. The scope of this study includes the range of non-hazardous solid wastes produced within our society, including municipal solid waste (MSW) and industrial solid waste (ISW), as well as industry-specific wastes from activities such as construction, demolition, and landclearing. Most solid waste management decisions continue to be made and ...

1994-09-01

372

Hawaii demand-side management resource assessment. Final report: DSM opportunity report  

Energy Technology Data Exchange (ETDEWEB)

The Hawaii Demand-Side Management Resource Assessment was the fourth of seven projects in the Hawaii Energy Strategy (HES) program. HES was designed by the Department of Business, Economic Development, and Tourism (DBEDT) to produce an integrated energy strategy for the State of Hawaii. The purpose of Project 4 was to develop a comprehensive assessment of Hawaii`s demand-side management (DSM) resources. To meet this objective, the project was divided into two phases. The first phase included development of a DSM technology database and the identification of Hawaii commercial building characteristics through on-site audits. These Phase 1 products were then used in Phase 2 to identify expected energy impacts from DSM measures in typical residential and commercial buildings in Hawaii. The building energy simulation model DOE-2.1E was utilized to identify the DSM energy impacts. More detailed information on the typical buildings and the DOE-2.1E ...

1995-08-01

373

Electrochemical noise measurements of sustained microbially influenced pitting corrosion in a laboratory flow loop system.  

Energy Technology Data Exchange (ETDEWEB)

Because of the chaotic nature of the corrosion process and the complexity of the electrochemical noise signals that are generated, there is no generally accepted method of measuring and interpreting these signals that allows the consistent detection and identification of sustained localized pitting (SLP) as compared to general corrosion. We have reexamined electrochemical noise analysis (ENA) of localized corrosion using different hardware, signal collection, and signal processing designs than those used in conventional ENA techniques. The new data acquisition system was designed to identify and monitor the progress of SLP by analyzing the power spectral density (PSD) of the trend of the corrosion current noise level (CNL) and potential noise level (PNL). Each CNL and PNL data point was calculated from the root-mean- square value of the ac components of current and potential fluctuation signals, which were measured ...

1999-01-13

374

The loss of lead in biological materials following different drying and ashing procedures  

International Nuclear Information System (INIS)

The loss of lead in various kinds of biological materials after drying and ashing is studied by using "2"0"3Pb as tracer which is intravenously injected into mice. The experimental results show that although the oven ashing can be used for determining the lead in samples of lung, kidney, and liver, etc., the oxygen plasma and high pressure digestion are the most suitable methods for the determination of lead in biological materials. (author) 5 refs.; 2 tabs.

375

Biological network analysis and comparison: mining new biological knowledge  

British Library Electronic Table of Contents (United Kingdom)

The mechanisms underlying life machinery are still not completely understood. Something is known, something is ?probably? known, other things are still unknown. Scientists all over the world are working very hard to clarify the processes regulating the cell life cycle and bioinformaticians try to support them by developing specialized automated tools. Within the plethora of applications devoted to the study of life mechanisms, tools for the analysis and comparison of biological networks are catching the attention of many researchers. It is interesting to investigate why.

2011-01-01

376

The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.  

Science.gov (United States)

In neurodegenerative conditions such as Alzheimer's and prion disease it has been shown that host genetic background can have a significant effect on susceptibility. Indeed, human genome-wide association studies (GWAS) have implicated several candidate genes. Understanding such genetic susceptibility is relevant to risks of developing variant CJD (vCJD) in populations exposed to bovine spongiform encephalopathy (BSE) and understanding mechanisms of neurodegeneration. In mice, aspects of prion disease susceptibility can be modelled by examining the incubation period following experimental inoculation. Quantitative trait linkage studies have already identified multiple candidate genes; however, it is also possible to take an individual candidate gene approach. Rarb and Stmn2 were selected as candidates based on the known association with vCJD. Because of the increasing overlap described between prion and Alzheimer's diseases we also chose Clu, Picalm and Cr1, which ...

2010-12-06

377

Technology Roadmaps - Electric and plug-in hybrid electric vehicles (EV/PHEV)  

Energy Technology Data Exchange (ETDEWEB)

The mass deployment of electric and plug-in hybrid electric vehicles (EVs and PHEVs) that rely on low greenhouse gas (GHG) emission electricity generation has great potential to significantly reduce the consumption of petroleum and other high CO2-emitting transportation fuels. The vision of the Electric and Plug-in Hybrid (EV/PHEV) Vehicles Roadmap is to achieve by 2050 the widespread adoption and use of EVs and PHEVs, which together represent more than 50% of annual LDV (light duty vehicle) sales worldwide. In addition to establishing a vision, this roadmap sets strategic goals to achieve it, and identifies the steps that need to be taken to accomplish these goals. This roadmap also outlines the roles and collaboration opportunities for different stakeholders and shows how government policy can support the overall achievement of the vision. The strategic goals for attaining the widespread adoption and use of EVs and PHEVs worldwide by 2050 ...

2011-06-15

378

Preliminary delineation of natural geochemical reactions, Snake River Plain aquifer system, Idaho National Engineering Laboratory and vicinity, Idaho  

Energy Technology Data Exchange (ETDEWEB)

The U.S. Geological Survey, in cooperation with the U.S. Department of Energy, is conducting a study to determine the natural geochemistry of the Snake River Plain aquifer system at the Idaho National Engineering Laboratory (INEL), Idaho. As part of this study, a group of geochemical reactions that partially control the natural chemistry of ground water at the INEL were identified. Mineralogy of the aquifer matrix was determined using X-ray diffraction and thin-section analysis and theoretical stabilities of the minerals were used to identify potential solid-phase reactants and products of the reactions. The reactants and products that have an important contribution to the natural geochemistry include labradorite, olivine, pyroxene, smectite, calcite, ferric oxyhydroxide, and several silica phases. To further identify the reactions, analyses of 22 representative water samples from sites tapping the ...

1997-05-01

379

Nuclear Forensics and Attribution for Improved Energy Security: The Use of Taggants in Nuclear Fuel  

International Nuclear Information System (INIS)

The Global Nuclear Energy Partnership (GNEP), recently announced by DOE Secretary Bodman, poses significant new challenges with regard to securing, safeguarding, monitoring and tracking nuclear materials. In order to reduce the risk of nuclear proliferation, new technologies must be developed to reduce the risk that nuclear material can be diverted from its intended use. Regardless of the specific nature of the fuel cycle, nuclear forensics and attribution will play key roles to ensure the effectiveness of nonproliferation controls and to deter the likelihood of illicit activities. As the leader of the DHS nuclear and radiological pre-detonation attribution program, LLNL is uniquely positioned to play a national leadership role in this effort. Ensuring that individuals or organizations engaged in illicit trafficking are rapidly identified and apprehended following theft or diversion of nuclear material provides a strong deterrent against unlawful activities. Key to ...

380

NGNP Composites R&D Technical Issues Study  

Energy Technology Data Exchange (ETDEWEB)

This study identifies potential applications and design requirements for ceramic materials (CMs) and ceramic composite materials (CCMs) in the NGNP hightemperature gas-cooled reactor (HTGR) primary circuit. Components anticipated for fabrication from non-graphite CMs and CCMs are identified along with recommended normal and off-normal operating conditions. The evaluation defines required dimensions and material properties of the candidate materials for normal operating conditions (NOC), anticipated transients, abnormal events, and design basis events. The report also identifies additional activities required for codifying the selected materials. The activities include ASTM Standard and ASME Code development and other work to support NRC licensing of the plant. Evaluation of the NGNP baseline design indicates components requiring either CMs or CCMs depend upon the reactor operating temperatures. For a ...

2008-09-01

381

A Human Reliability Analysis of Pre-Accident Human Errors in the Low Power and Shutdown PSA of the KSNP  

International Nuclear Information System (INIS)

Korea Atomic Energy Research Institute, using the ANS Low Power /Shutdown (LPSD)PRA Standard, evaluated the LPSD PSA model of the KSNP, Younggwang (YGN) Units 5 and 6, and identified the items to be improved. The evaluation results of human reliability analysis (HRA) of the pre-accident human errors in the LPSD PSA model of the KSNP showed that 13 items among 15 items of supporting requirements for those in the ANS PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for pre-accident human errors in the LPSD PSA model for the KSNP to improve its quality. We considered potential pre-accident human errors for all manual valves and control/instrumentation equipment of the systems modeled in the KSNP LPSD PSA model except reactor protection system/ engineering safety features actuation system. We reviewed 160 manual valves and 56 control/instrumentation equipment. The number of newly ...

2003-04-20

382

Biogenic iron oxyhydroxide formation at mid-ocean ridge hydrothermal vents: Juan de Fuca Ridge  

Energy Technology Data Exchange (ETDEWEB)

Here we examine Fe speciation within Fe-encrusted biofilms formed during 2-month seafloor incubations of sulfide mineral assemblages at the Main Endeavor Segment of the Juan de Fuca Ridge. The biofilms were distributed heterogeneously across the surface of the incubated sulfide and composed primarily of particles with a twisted stalk morphology resembling those produced by some aerobic Fe-oxidizing microorganisms. Our objectives were to determine the form of biofilm-associated Fe, and identify the sulfide minerals associated with microbial growth. We used micro-focused synchrotron-radiation X-ray fluorescence mapping (mu XRF), X-ray absorption spectroscopy (mu EXAFS), and X-ray diffraction (mu XRD) in conjunction with focused ion beam (FIB) sectioning, and highresolution transmission electron microscopy (HRTEM). The chemical and mineralogical composition of an Fe-encrusted biofilm was queried at different spatial scales, and the spatial relationship between primary ...

2008-05-22

385

Synthesis, characterization and biologic effects of polybrominated naphthalenes  

Energy Technology Data Exchange (ETDEWEB)

Although polybrominated naphthalenes (PBNs) are contaminants of the commercial fire retardant fireMaster BP-6, the individual PBN isomers have not been identified. In order to study PBNs possessing an analogous level of bromination to those found in fireMaster BP-6, three synthetic PBN mixtures, averaging 5.0, 5.3, and 5.6 bromines per naphthalene were synthetized and partially characterized. The PBN mixtures were administered to immature male Wistar rats and found to be potent inducers of cytochrome P-450-dependent monooxygenases. At the lowest dose tested, 30 mumol X kg-1, each PBN mixture caused maximal induction of benzo(a)pyrene hydroxylase activity. On the basis of enzyme activities, ligand-binding spectra and sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the PBN mixtures were determined to be 3-methylcholanthrene-type inducers of cytochrome P-450 (P-448), resembling qualitatively the most toxic polyhalogenated biphenyls, dibenzofurans, and ...

1984-07-01

386

Studies on sup(99m)Tc-pertechnetate from the MEK solvent extraction generator  

International Nuclear Information System (INIS)

Analysis by gas chromatography-mass spectrometry and high performance liquid chromatography has revealed organic residues in sup(99m)Tc-pertechnetate obtained from "9"9Mo-molybdate by extraction, using the organic solvent methylethylketone (MEK). The organic residues have been identified as either (i) low molecular weight carbonyl compounds such as formaldehyde, acetaldehyde and acetone, presumably caused by the effects of #gamma#-radiation on MEK, or (ii) condensation products resulting from the action of strong alkali on MEK during the extraction process. The quantities of organic residues varied from batch to batch of extracted pertechnetate; up to 40 #mu# mL"-"1 was found. When these compounds were tested, in rats, by addition to a pyrophosphate bone-seeking radiopharmaceutical, the tissue distribution was not significantly different from that in the control, which contained no added compound. Assay for "9"9Tc in MEK-derived pertechnetate indicated up to 10 ...

387

Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study  

DEFF Research Database (Denmark)

BACKGROUND: The aetiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (CI). RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of ...

2010-01-01

388

Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes.  

Science.gov (United States)

Previous investigations have shown that both the early biological response and the mechanical properties of a porous hydroxyapatite bone graft substitute are highly sensitive to its pore structure. The objective of this study was to evaluate whether the pore structure continued to influence bone integration in the medium to long term. Two screened batches of porous hydroxyapatite (PHA) designated as batch A and batch B, with porosities of approximately 60 and 80%, respectively, were selected for this study and implanted for periods of 5, 13, and 26 weeks into the lower femur of New Zealand White rabbits. Histomorphometric analysis of the absolute volume of bone ingrowth within batch A and B implants from 5 to 26 weeks showed that the absolute volume of bone ingrowth was consistently lower in batch A (10-21%), compared to batch B implants (24-31%). However, when the volume of bone ingrowth was normalised for the available pore space, this difference was reduced ...

2004-01-01

389

Development of an assay for a biomarker of pregnancy and early fetal loss  

Energy Technology Data Exchange (ETDEWEB)

Human chorionic gonadotropin (hCG) is a glycoprotein hormone, secreted by the syncytiotrophoblast cells of the fertilized ovum, that enters the maternal circulation at the time of endometrial implantation. It is composed of two nonidentical subunits; ..cap alpha.. and ..beta.., with molecular weights of 14 kD and 23 kD, respectively. Human chorionic gonadotropin binds to the same receptor as hLH and displays the same biological response, namely, to stimulate the declining function of the corpus luteum to produce progestins and estrogen late in the menstrual cycle. The differences in the structures of hCG and hLH have been exploited to develop antibodies that can measure hCG specifically in the presence of hLH. Two-site antibody binding assays have been developed, based on a surface immunological concept of hCG epitopes, that involve four distinct regions to which antibodies against hCG can bind simultaneously. Antibody cooperative effects, in conjunction with ...

1987-10-01

390

Combustion of refuse-derived fuels in grate and fluidised bed furnaces; Ersatzbrennstoffverbrennung in Rost- und Wirbelschichtoefen  

Energy Technology Data Exchange (ETDEWEB)

In addition to the goal of ensuring waste disposal, thermal waste treatment has always been aimed at the energy-efficient utilisation of wastes. Developments in waste management have led to an increase in high-calorific waste arisings. This is attributable to the use of mechanical-biological waste treatment as well as to segregated waste collection systems. High-calorific wastes are equivalent to fossil fuels in terms of their calorific content. Furthermore, they fulfil the legal requirements for conversion to energy. Another source of high-calorific wastes suitable for conversion to energy can be made available through the segregated disposal of industrial wastes, in many cases at low cost. These high-calorific fractions of varying origin and composition are referred to generically as substitute fuels, a term which implies quality and availability by reference to other fuels. Specifically, the term substitute fuel implies that it can be used for energy production ...

2005-07-01

391

Biological effects of electromagnetic radiation in the microwave range  

Energy Technology Data Exchange (ETDEWEB)

The book examines current experimental and clinical knowledge concerning the biological and biophysical effects of electromagnetic radiation, particularly that in the microwave range. The biophysical bases of the interaction of electromagnetic radiation with matter are reviewed with emphasis on biological systems, and the effects of radiation on critical biological systems, including the nervous, reproductive, visual and blood-forming systems are compared. Data concerning the lethal effects of nonionizing radiation is presented and characteristics of the effects of electromagnetic radiation on the whole mammalian organisms are examined. Various reactions of the neuroendocrine system to electromagnetic radiation are described, with particular attention given to the adrenal system, and the combined effects of ionizing and microwave radiation in the flight environment are discussed. Results are also presented of a series of ...

1980-01-01

392

Use of BWR/6 PRA to assess the effect of proposed new QA requirements  

International Nuclear Information System (INIS)

The probabilistic risk assessment (PRA) of the General Electric BWR/6 Mark III standard plant has been used to assess the effect of proposed new quality assurance requirements on the off-site plant risk. This work was performed by General Electric Company under contract to the Electric Power Research Institute. First, the potential changes in the reliability of structures, systems and components were estimated. Then those changes that could affect the event tree and fault tree results were identified. Finally these changes were propagated through the probabilistic risk assessment fault trees and event trees to determine the effect upon off-site plant risk. The results show that applying quality assurance requirements, very nearly equal to those of 10CFR50, Appendix B (3), to nearly all nonsafety-related structures, systems, and components would have a negligible effect on off-site plant risk. In this paper, first the proposed new quality ...

1985-02-01

393

Insulin-like growth factor binding protein-7 (IGFBP7) functions as a potential tumor suppressor in hepatocellular carcinoma (HCC).  

Science.gov (United States)

PURPOSE: Hepatocellular carcinoma (HCC) is a highly virulent malignancy with no effective treatment thus requiring innovative and effective targeted therapies. The oncogene Astrocyte elevated gene-1 (AEG-1) plays a seminal role in hepatocarcinogenesis and profoundly downregulates insulin-like growth factor binding protein-7 (IGFBP7). The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the relevance of IGFBP7 downregulation in mediating AEG-1 function.EXPERIMENTAL DESIGN: IGFBP7 expression was detected by immunohistochemistry in HCC tissue microarray and real-time PCR and ELISA in human HCC cell lines. Dual Fluorescence in situ hybridization was performed to detect loss of heterozygosity at IGFBP7 locus. Stable IGFBP7-overexpressing clones were established in the background of AEG-1-overexpressing human HCC cells and were analyzed for in vitro proliferation and senescence and in vivo tumorigenesis and ...

2011-09-16

394

Evaluating spatial patterns of dioxins in sediments to aid determination of potential implications for marine reptiles  

Energy Technology Data Exchange (ETDEWEB)

Recent investigations have identified elevated concentrations of polychlorinated dibenzo-p-dioxins (dioxins) in marine sediments and wildlife of Queensland, Australia. While it has been demonstrated that the contamination is widespread and predominantly land-based, limited information exists on the pathways and fate of these compounds within the near-shore marine system. This environment supports unique and threatened species including green sea turtles (Chelonia mydas). Adult green turtles are predominantly herbivorous, feeding on seagrass and algae. Apart from initial migration to feeding grounds (at {proportional_to}10 years of age) and intermittent migrations to breeding grounds (at {proportional_to}30-50 years and thereafter), green turtles remain and feed within relatively small home ranges. Long life-span (50 years or more), near-shore feeding grounds and highly specialized food requirements render green turtles potentially vulnerable to ...

2004-09-15

395

Ecological risk assessments for protected migratory birds and marine species at Midway Atoll  

Energy Technology Data Exchange (ETDEWEB)

In June 1997, the US Navy plans to close its Naval Air Facility on Sand Island and transfer the atoll to the US Fish and Wildlife Service for use as a National Wildlife Refuge. Midway provides breeding and feeding habitat for migratory seabirds, terrestrial and marine mammals, sea turtles and other reptiles, and a variety of reef fishes and invertebrates. As part of the base closure and transfer process, 36 sites of potential environmental concern were identified on Sand and Eastern islands. These sites include landfills and uncontrolled disposal areas, hazardous materials storage areas, abandoned transformers, sewer outfalls, and other potential hazardous waste sites. Potential contaminants include pesticides, PAHs, PCBs, and heavy metals. A screening ecological risk assessment was performed at each site with a goal of determining whether contaminants could pose any current or future risks to protected ...

1995-12-31

396

From tankers to tissues : tracking the degradation and fate of oil discharges in Port Valdez, Alaska  

Energy Technology Data Exchange (ETDEWEB)

An average of 9 million gallons per day of oil-contaminated ballast water off loaded from tankers are treated at the Alyeska Pipeline Service Company Ballast Water Treatment Facility at the terminus of the Trans-Alaska Pipeline in Port Valdez, Alaska. This paper focuses on the results of 2 Prince William Sound Regional Citizens' Advisory Council monitoring programs which detail changes in the chemical composition of treated ballast water as it moves from tankers through the facility and subsequently traces the effluent hydrocarbons into the receiving environment of Port Valdez. The treatment facility involves gravity separation tanks, dissolved air flotation cells and biological treatment tanks. Effluent containing traces of volatile aromatics, including benzene, toluene, ethylbenzene and xylenes, low levels of oil, saturated hydrocarbons and polycyclic aromatic hydrocarbons is being continuously discharged to Port Valdez. Because of the extremely large ...

2005-07-01

397

Potential Increases in Mortality due to Global Warming  

Science.gov (United States)

... predicting potential increases in human mortality due to global warming....

398

POTENTIATION BY PENTOBARBITAL OF THE PROTECTIVE ...  

Science.gov (United States)

... Accession Number : AD0268549. Title : POTENTIATION BY PENTOBARBITAL OF THE PROTECTIVE EFFECT OF AET AGAINST GAMMA RAYS. ...

1961-10-01

399

The Future of Induced Pluripotent Stem Cells for Cardiac Therapy and Drug Development.  

Science.gov (United States)

The field of stem cell research was revolutionized with the advent of induced pluripotent stem cells. By reprogramming somatic cells to pluripotent stem cells, most ethical concerns associated with the use of embryonic stem cells are overcome, such that many hopes from the stem cell field now seem a step closer to reality. Several methods and cell sources have been described to create induced pluripotent stem cells and we discuss their characteristics in terms of feasibility and efficiency. From these cells, cardiac progenitors and cardiomyocytes can be derived by several protocols and most recent advances as well as remaining limitations are being discussed. However in the short time period this technology has been around, evidence emerges that induced pluripotent stem cells may be more prone to genetic defects and maintain an epigenetic memory and thus may not be entirely the same as embryonic stem cells. Despite the lack of a complete fundamental understanding of stem cell ...

2011-09-15

400

Sol-gel-immobilized Tris(2,2'-bipyridyl)ruthenium(II) electrogenerated chemiluminescence sensor for high-performance liquid chromatography  

International Nuclear Information System (INIS)

The sol-gel-immobilized Tris(2,2'-bipyridyl)ruthenium(II) [Ru(bpy)_3 "2"+] electrogenerated chemiluminescence (ECL) sensor was applied to the reversed-phase high-performance liquid chromatography (HPLC) determination of phenothiazine derivatives (promazine, chlorpromazine, triflupromazine, thioridazine, and trifluoperazine) and erythromycin in human urine samples. In this method, Ru(bpy)_3 "2"+ was immobilized in sol-gel-derived titania (TiO_2)-Nafion nanocomposite films coated on a dual platinum electrode. This method eliminates an extra pump needed for the delivery of Ru(bpy)_3 "2"+ reagent into a reaction/observation zone in front of photomultiplier tube because the immobilized-Ru(bpy)_3 "2"+ is recycled on the electrode surface by an applied potential at +1.3 V versus Ag/AgCl (3 M NaCl) reference electrode. The resulting analytical performances such as detection limit, working range, sensitivity, and measurement precision were slightly worse than those obtained ...

2005-06-13

401

Sol-gel-immobilized Tris(2,2'-bipyridyl)ruthenium(II) electrogenerated chemiluminescence sensor for high-performance liquid chromatography  

Energy Technology Data Exchange (ETDEWEB)

The sol-gel-immobilized Tris(2,2'-bipyridyl)ruthenium(II) [Ru(bpy){sub 3} {sup 2+}] electrogenerated chemiluminescence (ECL) sensor was applied to the reversed-phase high-performance liquid chromatography (HPLC) determination of phenothiazine derivatives (promazine, chlorpromazine, triflupromazine, thioridazine, and trifluoperazine) and erythromycin in human urine samples. In this method, Ru(bpy){sub 3} {sup 2+} was immobilized in sol-gel-derived titania (TiO{sub 2})-Nafion nanocomposite films coated on a dual platinum electrode. This method eliminates an extra pump needed for the delivery of Ru(bpy){sub 3} {sup 2+} reagent into a reaction/observation zone in front of photomultiplier tube because the immobilized-Ru(bpy){sub 3} {sup 2+} is recycled on the electrode surface by an applied potential at +1.3 V versus Ag/AgCl (3 M NaCl) reference electrode. The resulting analytical performances such as detection limit, working range, sensitivity, and measurement ...

2005-06-13

402

Planetary protection protecting earth and planets against alien microbes  

International Nuclear Information System (INIS)

Protecting Earth and planets against the invasion of 'alien life forms' is not military science fiction, but it is the peaceful daily job of engineers and scientists of space agencies. 'Planetary Protection' is preventing microbial contamination of both the target planet and the Earth when sending robots on interplanetary space mission. It is important to preserve the 'natural' conditions of other planets and to not bring with robots 'earthly microbes' (forward contamination) when looking for 'spores of extra terrestrial life'. The Earth and its biosphere must be protected from potential extraterrestrial biological contamination when returning samples of other planets to the Earth (backward contamination). The NASA-Caltech Laboratory for Planetary Protection of Dr. Kasthuri Venkateswaran at the Jet Propulsion Laboratory (JPL) (California, USA) routinely monitors and characterizes the microbes of NASA spacecraft assembly rooms and space robots ...

2006-04-01

403

New tools for human fat cell alpha-2A adrenoceptor characterization. Identification on membranes and on intact cells using the new antagonist (3H)RX821002  

Energy Technology Data Exchange (ETDEWEB)

The pharmacology of the alpha-2 adrenoceptor of the human adipocyte was improved by using some new alpha-2 antagonists from different chemical families (imidazolines, benzazepines and benzofuroquinolizines) in biological and binding assays. Moreover, investigations were also carried out to define the binding properties of a new imidazolinic antagonist, RX821002 (2-(2-methoxy-1,4-benzodioxan-2yl)-2-imidazoline), which could be a potential radioligand. (3H)RX821002 binding was very rapid and reversible. Saturation isotherms indicated that (3H)RX821002 labeled, with high affinity, a homogeneous population of noninteracting binding sites with a mean Kd of 0.98 +/- 0.05 nM (n = 6). The binding of (3H)RX821002 on the human fat cell alpha-2 adrenoceptor displayed a specificity which is strictly similar to that obtained with (3H)rauwolscine and which is classical for an alpha-2 A adrenoceptor. The binding parameters of (3H)RX821002 were compared with ...

1990-01-01

404

Generation of human cortical neurons from a new immortal fetal neural stem cell line  

International Nuclear Information System (INIS)

Isolation and expansion of neural stem cells (NSCs) of human origin are crucial for successful development of cell therapy approaches in neurodegenerative diseases. Different epigenetic and genetic immortalization strategies have been established for long-term maintenance and expansion of these cells in vitro. Here we report the generation of a new, clonal NSC (hc-NSC) line, derived from human fetal cortical tissue, based on v-myc immortalization. Using immunocytochemistry, we show that these cells retain the characteristics of NSCs after more than 50 passages. Under proliferation conditions, when supplemented with epidermal and basic fibroblast growth factors, the hc-NSCs expressed neural stem/progenitor cell markers like nestin, vimentin and Sox2. When growth factors were withdrawn, proliferation and expression of v-myc and telomerase were dramatically reduced, and the hc-NSCs differentiated into glia and neurons (mostly glutamatergic and GABAergic, as well as tyrosine ...

2007-02-01

405

Dosimetric evaluation and therapeutic response to iodine-131 labelled lipiodol in treatment of hepatocellular carcinomas; Evaluation dosimetrique et reponse therapeutique de la curietherapie metabolique des hepatocarcinomes par le lipiodol marque par l'iode 131  

Energy Technology Data Exchange (ETDEWEB)

Faced with increasing indications for the use of iodine-131 labelled lipiodol in the treatment of hepatocellular carcinoma (HCC), it appears essential to develop an individualized dosimetrY so we can predict the potential effectiveness of this treatment and adjust the activity to be injected. We developed a dosimetric protocol based on imagery and dedicated to calculation of the tumoral dose during the treatment of hepatocellular carcinoma by iodine-131 labelled lipiodol. This concept was developed on a SPECT- CT gantry, and integrates corrections for the phenomena of attenuation, diffusion and dead time. The dose is calculated according to the formalism proposed by the Medical Internal Radiation Dose Committee (MIRD). This protocol was applied to a series of 41 patients in the framework of a retrospective study. The results obtained in terms of biodistribution are compatible with previously published data. The total biological response rate is ...

2006-12-15

406

Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent  

Science.gov (United States)

BackgroundDespite an ever-improving understanding of the molecular biology of cancer, the treatment of most cancers has not changed dramatically in the past three decades and drugs that do not discriminate between tumor cells and normal tissues remain the mainstays of anticancer therapy. Since Hsp90 is typically involved in cell proliferation and survival, this is thought to play a key role in cancer, and Hsp90 has attracted considerable interest in recent years as a potential therapeutic target.MethodsWe focused on the interaction of Hsp90 with its cofactor protein p60/Hop, and engineered a cell-permeable peptidomimetic, termed "hybrid Antp-TPR peptide", modeled on the binding interface between the molecular chaperone Hsp90 and the TPR2A domain of Hop.ResultsIt was demonstrated that this designed hybrid Antp-TPR peptide inhibited the interaction of Hsp90 with the TPR2A domain, inducing cell death of breast, pancreatic, renal, lung, prostate, ...

2011-01-14

407

Deforestation of Rondonia, Brazil, from 1975 to 2001  

Science.gov (United States)

Throughout much of the 1980s, deforestation in Brazil eliminated more than 15,000 square kilometers (9000 square miles) per year. That pace has only increased through the 90s and into the 21st century. Brazil is also home to more than a quarter of Earths tropical forests. Considering that the band of lush green that circles the globe through many equatorial nations is fundamental to the overall health of the whole planets environment, careful monitoring of forest health in the tropics is essential. Tropical forests act as major carbon sinks, places where ambient carbon dioxide in the atmosphere can be absorbed by growing things and sequestered for years. Definitive evidence shows that excess carbon dioxide can contribute to the greenhouse effect and speed global warming. Similarly, tropical forests also act as a primary producer of oxygen. In the respiration process that absorbs gaseous carbon dioxide, trees and other plants give off oxygen. It is for these and a host of other reasons ...

2001-04-19

408

Assessment of interference in biosorption of a heavy metal  

Energy Technology Data Exchange (ETDEWEB)

Biosorption of heavy metals by various biological materials has been studied extensively in the last decade due to its potential particularly in wastewater treatment. The presence of a large number of metals in industrial metal-bearing solutions makes it necessary to investigate their effect on the final metal uptake by individual biosorbent materials. Nonliving biomass of Sargassum, a brown marine alga, is capable of binding more than 10% of its dry weight in toxic cadmium ions. Although ubiquitous iron interferes with Cd uptake, only approximately 4.5% of it is sequestered (biomass dry weight). Biosorption of both metals at pH 4.5 could be described by Langmuir-type isotherms with b, the affinity-related coefficient (Cd: b = 0.015; Fe: b = 0.027). The interference of Fe with Cd uptake, and vice versa, was assessed by deriving three-dimensional equilibrium two-metal sorption isotherm surfaces, smoothed and cut to reveal the inhibition effect ...

1997-05-20

409

An iterative filtered backprojection inverse treatment planning algorithm for tomotherapy  

International Nuclear Information System (INIS)

Purpose: An inverse treatment planning algorithm for tomotherapy is described. Methods and Materials: The algorithm iteratively computes a set of nonnegative beam intensity profiles that minimizes the least-squares residual dose defined in the target and selected normal tissue regions of interest. At each iteration the residual dose distribution is transformed into a set of residual beam profiles using an inversion method derived from filtered backprojection image reconstruction theory. These 'residual' profiles are used to correct the current beam profile estimates resulting in new profile estimates. Adaptive filtering is incorporated into the inversion model so that the gross structure of the dose distribution is optimized during initial iterations of the algorithm, and the fine structure corresponding to edges is obtained at later iterations. A three dimensional, kernel based, convolution/superposition dose model is used to compute dose during each iteration. Results: Two clinically ...

1995-07-15

410

An investigation of some Turkish herbal medicines in Salmonella typhimurium and in the COMET assay in human lymphocytes.  

Science.gov (United States)

Medicinal plants play a major role in the life of Turkish people and of late medicinal plant usage has increased in many countries. Green plants in general contain mutagenic and carcinogenic substances, but there is little information about the biological activities of herbal medicine. In the present study, therefore, various Turkish medicinal herbs were investigated for their genotoxic potential in the Salmonella typhimurium microsomal activation assay and the alkaline single cell gel electrophoresis (COMET) assay. Extracts from these medicinal herbs and some fractions of these extracts were examined. The species investigated were Arctium minus, Ecballium elatterium, Momordica charantia, Plantago major, Urtica dioica, Viscum album, Salvia triloba, Euphorbia rigida, Stachys lavandulifolia, Acteoside, Abies nordmannia. They are used for various immune disorders and are applied either topically or taken orally as a herbal tea. Of the 19 samples ...

1996-01-01

411

Yakima River Species Interactions Studies, Annual Report 1999.  

Energy Technology Data Exchange (ETDEWEB)

Species interactions research and monitoring was initiated in 1989 to investigate ecological interactions among fish in response to proposed supplementation of salmon and steelhead in the upper Yakima River basin. This is the eighth of a series of progress reports that address species interactions research and pre-supplementation monitoring of fishes in the Yakima River basin. Data have been collected prior to supplementation to characterize the ecology and demographics of non-target taxa (NTT) and target taxon, and develop methods to monitor interactions and supplementation success. Major topics of this report are associated with implementing NTT monitoring prescriptions for detecting potential impacts of hatchery supplementation, hatchery fish interactions, and monitoring fish predation indices. This report is organized into four chapters, with a general introduction preceding the first chapter. This annual report summarizes data collected primarily by the ...

2001-06-01

412

X-ray phase imaging using a X-ray tube with a small focal spot. Improvement of image quality in mammography  

International Nuclear Information System (INIS)

Phase contrast X-ray imaging has been studied intensively using X-rays from synchrotron radiation and micro-focus X-ray tubes. However, these studies have revealed the difficulty of this technique's application to practical medical imaging. We have created a phase contrast imaging technique using a molybdenum X-ray tube with a small focal spot size for mammography. We identified the radiographic conditions in phase contrast magnification mammography with a screen-film system, where edge effect due to phase contrast overcomes geometrical unsharpness caused by the 0.1 mm-focal spot of a molybdenum X-ray tube. The edge enhancement due to phase imaging was observed in an image of a plastic tube, and then geometrical configuration of the X-ray tube, the object and the screen-film system was determined for phase imaging of mammography. In order to investigate a potential for medical application of this method, we conducted evaluation of the images of ...

2002-03-01

413

Wetlands of Argonne National Laboratory-East DuPage County, Illinois  

Energy Technology Data Exchange (ETDEWEB)

Jurisdictional wetlands of the Argonne National Laboratory-East (ANL-E) site in DuPage County, Illinois, were delineated in the summer and autumn of 1993 in accordance with the 1987 US Army Corps of Engineers methodology. Potential wetland sites with an area greater than 500 m{sup 2} (0.05 ha [0.124 acre]) were identified for delineation on the basis of aerial photographs, the DuPage County soil survey, and reconnaissance-level field studies. To qualify as a jurisdictional wetland, an area had to support a predominance of hydrophytic vegetation as well as have hydric soil and wetland hydrology. Thirty-five individual jurisdictional wetlands were delineated at ANL-E, totaling 180,604 m{sup 2} (18.1 ha [44.6 acres]). These wetlands were digitized onto the ANL-E site map for use in project planning. Characteristics of each wetland are presented -- including size, dominant plant species and their indicator status, hydrologic characteristics ...

1994-03-01

414

Use of a temperature-initiated passive cooling system (TIPACS) for the modular high-temperature gas-cooled reactor cavity cooling system (RCCS)  

Energy Technology Data Exchange (ETDEWEB)

A new type of passive cooling system has been invented (Forsberg 1993): the Temperature-Initiated Passive Cooling System (TIPACS). The characteristics of the TIPACS potentially match requirements for an improved reactor-cavity-cooling system (RCCS) for the modular high-temperature gas-cooled reactor (MHTGR). This report is an initial evaluation of the TIPACS for the MHTGR with a Rankines (steam) power conversion cycle. Limited evaluations were made of applying the TIPACS to MHTGRs with reactor pressure vessel temperatures up to 450 C. These temperatures may occur in designs of Brayton cycle (gas turbine) and process heat MHTGRs. The report is structured as follows. Section 2 describes the containment cooling issues associated with the MHTGR and the requirements for such a cooling system. Section 3 describes TIPACS in nonmathematical terms. Section 4 describes TIPACS`s heat-removal capabilities. Section 5 analyzes the operation of the temperature-control mechanism ...

1994-04-01

415

Thermodynamics, lattice stability and defect structure of strontium silicides via first-principles calculations  

International Nuclear Information System (INIS)

The thermodynamics of the Sr-Si system is of fundamental importance for the understanding of eutectic modification of Al-Si alloys. At the same time, strontium silicides have recently been found to have potential applications in electronic devices. Renewed research efforts have led to a re-evaluation of the phase equilibria in this system, resulting in the discovery of previously undetected stable intermetallic compounds. In this work, we investigate the finite temperature thermodynamic properties of the stable (and metastable) Sr-Si intermetallics. The vibrational properties of the intermetallic compounds are calculated within harmonic theory, with quasi-harmonic corrections to account for the effects of thermal expansion. The total free energies of the compounds are computed considering vibrational and electronic contributions, as well as weak anharmonic corrections. The ground state of the system is predicted and compared to previous experimental and ...

2009-09-18

416

The effects of pressure on the electronic, transport and dynamical properties of AuX_2 (X = Al, Ga and In)  

International Nuclear Information System (INIS)

The electronic band structure, transport properties, and lattice dynamics in AuX_2 (X = Al, Ga and In) under high pressure have been extensively studied with full potential linearized augmented plane wave and pseudopotential plane wave methods. The theoretical results for the electronic band structure and Fermi surface reveal pressure-induced electronic topological transitions (ETTs) in AuGa_2 and AuIn_2, while they are absent in AuAl_2, in excellent agreement with the experimental observations. Moreover, calculations of the transport properties at different pressures reveal subtle changes in the band structure close to the Fermi surface of the three intermetallic compounds. It is clear that the anomalies in transport properties are due to ETTs. Interestingly, a pressure-induced soft transverse acoustic (TA) phonon mode is identified only in AuGa_2. The TA phonon instability at the Brillouin zone boundary L point might be responsible for the ...

2007-10-24

417

The condition monitoring of fluid-filled taped cables employed in underground transmission through dissolved gas analysis  

Energy Technology Data Exchange (ETDEWEB)

There is an urgent need to monitor the condition of fluid-filled taped (FFT) cables. The Dissolved-Gas Analysis (DGA) technique that has been successfully applied to power transformers holds great potential for the preventive maintenance of FFT cables. However, before this emerging technique can be properly applied to cables, a suitable fluid sampling and subsequent gas analysis method had to be developed, including the generation of both laboratory and field data to aid in data interpretation. Data on gas saturation levels in various cable fluids have been presented. This paper describes a novel method developed specifically for FFT cables and discusses field results so obtained. The type, distribution and concentration of gases from fluid alone and paper alone under electrical stress has been presented, including the differences between normal and not-so-normal cable systems as demonstrated by DGA. The concept of wet tensile strength has been introduced to the ...

1994-12-31

418

The Star Clusters in the Irregular Galaxy NGC 4449  

CERN Document Server

We examine the star clusters in the irregular galaxy NGC 4449. We use a near-infrared spectrum and broad-band images taken with the HST to place a limit of 8--15 Myrs on the age of the bright central ojbect in NGC 4449. Its luminosity and size suggest that it is comparable to young super star clusters. However, there is a peculiar nucleated-bar structure at the center of this star cluster, and we suggest that this structure is debris from the interaction that has produced the counter-rotating gas systems and extended gas streamers in the galaxy. From the images we identify 60 other candidate compact star clusters in NGC 4449. Fourteen of these could be background elliptical galaxies or old globular star clusters. Of the star clusters, three, in addition to the central object, are potentially super star clusters, and many others are comparable to the populous clusters found in the LMC. The star clusters span a large range in ages with no obvious ...

2000-01-01

419

The Coming Nuclear Renaissance for Next Generation Safeguards Specialists--Maximizing Potential and Minimizing the Risks  

Energy Technology Data Exchange (ETDEWEB)

This document is intended to provide an overview of the workshop entitled 'The Coming Nuclear Renaissance for the Next Generation Safeguards Experts-Maximizing Benefits While Minimizing Proliferation Risks', conducted at Oak Ridge National Laboratory (ORNL) in partnership with the Y-12 National Security Complex (Y-12) and the Savannah River National Laboratory (SRNL). This document presents workshop objectives; lists the numerous participant universities and individuals, the nuclear nonproliferation lecture topics covered, and the facilities tours taken as part of the workshop; and discusses the university partnership sessions and proposed areas for collaboration between the universities and ORNL for 2009. Appendix A contains the agenda for the workshop; Appendix B lists the workshop attendees and presenters with contact information; Appendix C contains graphics of the evaluation form results and survey areas; and Appendix D summarizes the responses to the workshop ...

2009-01-01

420

Student Concern and Potential Action Regarding Nuclear Threat.  

Science.gov (United States)

Throughout their history, Americans have believed that citizens' fulfillment of their individual duties in a participatory democracy is at least partly met through the forming of groups around important societal issues. Given the complex nature of political socialization, this study investigated identifiable determinants of social action that might be used to advantage in educating young people for citizenship in a democracy. This study attempted to differentiate among junior high, high school and college students (N=517) who were inclined and not inclined to act on their concerns about nuclear threat with selected demographic, psychological, political, and educational variables. The results of a discriminant functional analysis indicated that in comparison with the non-action group, students in the action group were characterized by reporting less trust in government, more exposure to sources of nuclear war information, more political knowledge, a more liberal ...

1990-08-01

421

Structure activity relationships to assess new chemicals under TSCA  

International Nuclear Information System (INIS)

Under Section 5 of the Toxic Substances Control Act (TSCA), manufacturers must notify the US Environmental Protection Agency (EPA) 90 days before manufacturing, processing, or importing a new chemical substance. This is referred to as a premanufacture notice (PMN). The PMN must contain certain information including chemical identity, production volume, proposed uses, estimates of exposure and release, and any health or environmental test data that are available to the submitter. Because there is no explicit statutory authority that requires testing of new chemicals prior to their entry into the market, most PMNs are submitted with little or no data. As a result, EPA has developed special techniques for hazard assessment of PMN chemicals. These include (1) evaluation of available data on the chemical itself, (2) evaluation of data on analogues of the PMN, or evaluation of data on metabolites or analogues of metabolites of the PMN, (3) use of quantitative structure activity relationships ...

1990-06-27

422

Spectroscopic properties of Er"3"+ ions in cadmium and alkali cadmium borosulphate glasses  

International Nuclear Information System (INIS)

Spectroscopic properties of Er"3"+ : CBS (CdSO_4 + B_2O_3 and R_2SO_4 + CdSO_4 + B_2O_3, R_2SO_4 = Li_2SO_4.H_2O, Na_2SO_4, K_2SO_4 and Gd_2(SO_4)_3.8H_2O) glasses are reported. The assigned energy level data of Er"3"+(4f"1"1) in these glasses are analysed in terms of a parametrized model Hamiltonian. The standard deviations of the data fits are between 39 and 47 cm"-"1 so that the energy level schemes of the Er"3"+(4f"1"1) ions in borosulphate (CBS) glasses are reasonably well reproduced. Radiative properties for the fluorescent levels of Er"3"+ : CBS glasses are determined by using the Judd-Ofelt theory. The potential laser transitions are identified with the help of predicted radiative properties which are compared and discussed with similar results. (author).

1997-01-01

423

Spectrally condensed fluid turbulence and L-H transitions in plasma  

International Nuclear Information System (INIS)

Recent experimental and theoretical studies of two-dimensional (2D) turbulence reveal that spectrally condensed turbulence which is a system of coupled large-scale coherent flow and broadband turbulence, is similar to plasma turbulence near the L-H transition threshold. Large condensate vortices fed via the turbulent inverse energy cascade, can control both the level of the broadband turbulence by shear decorrelation, and the energy injected into turbulence at the forcing scale via sweeping of the forcing-scale vortices. The interaction between these ingredients of spectrally condensed fluid turbulence is in many aspects similar to the interactions in the zonal flow-GAMs-turbulence system in plasma. In this paper we overview recent results on condensed 2D turbulence and present evidence of interaction between its three components: condensate structures, turbulence and forcing-scale vortices. This is compared with the modifications in the spectra of plasma electrostatic ...

2009-06-01

424

Some computer simulations of semiconductor thin film growth and strain relaxation in a unified atomistic and kinetic model  

Energy Technology Data Exchange (ETDEWEB)

An overview is provided of an evolving atomistic and kinetic model of semiconductor growth that unifies the main features of strain relaxation in low and high lattice misfit heteroepitaxy. The model reveals a kinetic pathway for dislocation formation during growth with little or no energy cost at low misfits, thus providing a way out of the longstanding dilemma of too high dislocation nucleation energies predicted by classical theories of the equilibrium behavior of a fixed number of particles at low misfits. The essential kinetic process underlying the model are identified on the basis of comparison of the predictions of kinetic Monte-Carlo simulations of growth with real-time or in-situ data obtained in such experiments as reflection high-energy electron diffraction (RHEED) and scanning probe microscopy (SPM). Relative significance of these atomistic kinetic processes is shown to naturally lead to strain relaxation via defect initiation at low misfits while ...

1996-12-31

425

Silicate bonded ceramics of laterites  

International Nuclear Information System (INIS)

Sodium silicate is vacuum impregnated in bauxite waste (red mud) at room temperature to develop ceramics of mechanical properties comparable to the sintered ceramics. For a concentration up to 10% the fracture toughness increases from 0.12 MNm"-"3"/"2 to 0.9 MNm"-"3"/"2, and the compressive strength from 7 MNm"-"2 to 30 MNm"-"2. The mechanical properties do not deteriorate, when soaked in water for an entire week. The viscosity and the concentration of the silicate solution are crucial, both for the success of the fabrication and the economics of the process. Similar successful results have been obtained for bauxite and lime stone, even though the latter has poor weathering properties. With scanning electron microscopy and energy dispersive analysis, an attempt is made to identify the crystals formed in the composite, which are responsible for the strength. The process is an economic alternative to the sintered ceramics in the construction industry in the tropical ...

2006-06-16

426

Session 6: Effect of Zeolite Supported Catalysts on the Decomposition of Pyridine  

Energy Technology Data Exchange (ETDEWEB)

The aim of this work is to test the catalytic oxidation of pyridine over zeolite-supported catalysts and to compare the difference in their activities for the oxidation of pyridine. The catalytic oxidation of pyridine pollutant on a series of copper-supported catalysts, inclusive of Cu/beta, Cu/ZSM-5, Cu/MCM-41 and Cu/{gamma}-Al{sub 2}O{sub 3}, in the presence of excess oxygen was studied. The activity of the copper-supported catalysts for the pyridine oxidation could be correlated with the binding energy of oxygen coordinated to metal copper, while the ability to control the yield of NO{sub x} appeared to be strongly dependent on the binding energy of NO bonded to metal copper. On these catalysts, two copper species, Cu(H{sub 2}O){sub 6}{sup 2+} ions and CuO were identified, in which Cu{sup 2+} ions had higher activity for the NO{sub x} control but poorer activity for the pyridine oxidation. Amongst those metals-supported beta catalysts, Cu/beta was the most ...

2004-07-01

427

SAGD or cold production : a case study for an Orinoco heavy oil field  

Energy Technology Data Exchange (ETDEWEB)

This paper examined the potential of steam assisted gravity drainage (SAGD) technology for increasing productivity in the Orinoco heavy oilfields of Venezuela. A computerized simulation tool was used to generate a matrix of parameters needed to compare SAGD processes with cold production techniques in the Carabobo region of the Orinoco belt. Parameters included vertical connectivity, oil saturation, and net pay. Monte Carlo simulations and uncertainty assessments were used to generate cold production scenarios. Optimized SAGD scenarios were then designed for each case. Results of the study suggested that vertical local connectivity was an important parameter for the identification of suitable areas for EOR and SAGD. Unfavorable conditions for the application of SAGD during early production stages were identified. SAGD behaviour improved through the adjustment of injection rates during different stages of the process. It was concluded that the ...

2008-07-01

428

Rural Education and the Beginning Teacher.  

Science.gov (United States)

This paper addresses the major issues beginning teachers face in their first postings to rural areas in Australia. The issues go beyond pedagogy. Beginning teachers need to understand social factors affecting rural communities so they can link lessons to the realities experienced by students. Geographic isolation affects the provision of education in terms of time taken to travel, cost, terrain, and technology. Rural communities have groups that are socially isolated from each other and from the staff in schools. In order to teach effectively, teachers need to be aware of the social context of the community in which they live and work. Teachers in rural areas suffer from professional isolation and often confront teaching situations for which they have had little formal preparation. Communities in remote places often move quickly to adopt technological means to overcome their isolation. Teachers in rural areas need to identify and promote the media skills of ...

1992-02-01

429

Remediation of contaminated agricultural soils near a former Pb/Zn smelter in Austria: Batch, pot and field experiments  

International Nuclear Information System (INIS)

Metal contaminated crops from contaminated soils are possible hazards for the food chain. The aim of this study was to find practical and cost-effective measures to reduce metal uptake in crops grown on metal contaminated soils near a former metal smelter in Austria. Metal-inefficient cultivars of crop plants commonly grown in the area were investigated in combination with in-situ soil amendments. A laboratory batch experiment using 15 potential amendments was used to select 5 amendments to treat contaminated soil in a pot study using two Barley (Hordeum vulgare L.) cultivars that differed in their ability to accumulate cadmium. Results from this experiment identified 3 of these amendments for use in a field trial. In the pot experiment a reduction in ammonium nitrate extractable Cd (<41%) and Pb (<49%) compared to the controls was measured, with a concurrent reduction of uptake into barley grain (Cd < 62%, Pb < 68%). In the field ...

2006-11-01

430

Public involvement in the siting of contentious facilities; Lessons from the radioactive waste repository siting programmes in Canada and the United States, with special reference to the Swedish repository siting process  

Energy Technology Data Exchange (ETDEWEB)

This report describes the conclusion of a two-part programme, begun in 1994 with the overall aim of assisting in the development of an acceptable public participation strategy for use in Sweden for the siting of contentious facilities, with particular reference to the ongoing siting programme for a deep repository for spent nuclear fuel. The first part of the work programme, a global review of siting practice, was reported as SSI Rapport 94-15, in November 1994. This recommended further detailed studies of at least two individual programmes, which have now been carried out in Canada and the United States, and are reported on here. They involved face to face meetings with many of the main stake holders in the two programmes and enabled valuable insight to be gained into the potential problems associated with increased public participation, as well as identifying good practice where it exists. The lessons learned have then been applied to the ...

1997-08-01

431

Plutonium Finishing Plant safety evaluation report  

Energy Technology Data Exchange (ETDEWEB)

The Plutonium Finishing Plant (PFP) previously known as the Plutonium Process and Storage Facility, or Z-Plant, was built and put into operation in 1949. Since 1949 PFP has been used for various processing missions, including plutonium purification, oxide production, metal production, parts fabrication, plutonium recovery, and the recovery of americium (Am-241). The PFP has also been used for receipt and large scale storage of plutonium scrap and product materials. The PFP Final Safety Analysis Report (FSAR) was prepared by WHC to document the hazards associated with the facility, present safety analyses of potential accident scenarios, and demonstrate the adequacy of safety class structures, systems, and components (SSCs) and operational safety requirements (OSRs) necessary to eliminate, control, or mitigate the identified hazards. Documented in this Safety Evaluation Report (SER) is DOE`s independent review and evaluation of the PFP FSAR and ...

1995-01-01

432

Phosphorous adsorption and precipitation in a permeable reactive wall: Applications for wastewater disposal systems  

Energy Technology Data Exchange (ETDEWEB)

A permeable reactive mixture has been developed using low cost, readily available materials that is capable of providing effective, long-term phosphorous treatment in areas impacted by on-land wastewater disposal. The reactive mixture creates a geochemical environment suitable for P-attenuation by both adsorption and precipitation reactions. Potential benefits include significant reductions in phosphorous loading to receiving groundwater and surface water systems, and the accumulation of P-mass in a finite and accessible volume of material. The mixture may be applied as a component within surface treatment systems or in subsurface applications such as horizontal or vertical permeable reactive walls. The mixture averaged > 90% treatment efficiency over 3.6 years of continuous-flow laboratory column experiments. The mixture was further evaluated at the pilot-scale to treat municipal wastewater, and the field-scale to treat a well-characterized septic system plume ...

1997-12-31

433

Oxidation/sulfidation of material candidates for distributed solar receiver thermochemical transport program  

Energy Technology Data Exchange (ETDEWEB)

Metals for potential use in the dissociator and the synthesizer reactors of a distributed solar receiver thermochemical transport loop utilizing SO/sub 3//SO/sub 2//O/sub 2/ molecular chemistry includes stainless steels and iron-base, nickel-base and cobalt-base superalloys. We tested these alloys in SO/sub 2//O/sub 2/ mixtures and SO/sub 3/ gas at 500/sup 0/C and 900/sup 0/C, respectively, for times of up to four weeks. Weight gain measurements were used to determine the oxidation/sulfidation kinetics and electron microprobe analysis was used to measure penetration of oxygen and sulfur into the metal and to identify the formation of internal oxides and sulfides. Results of these tests showed that the most promising candidates are those containing sufficient quantities of both aluminum and chromium alloying additions to be alumina and chromia formers, such as Kanthal A-1, Nimonic 105 and Cabot 214.

1986-01-01

434

Olive bagasse (Olea europa L.) pyrolysis  

Energy Technology Data Exchange (ETDEWEB)

Olive bagasse (Olea europea L.) was pyrolysed in a fixed-bed reactor. The effects of pyrolysis temperature, heating rate, particle size and sweep gas flow rates on the yields of the products were investigated. Pyrolysis runs were performed using pyrolysis temperatures between 350 and 550 {sup o}C with heating rates of 10 and 50 {sup o}C min{sup -} {sup 1}. The particle size and sweep gas flow rate varied in the ranges 0.224-1.8 mm and 50-200 cm{sup 3} min {sup -1}, respectively. The bio-oil obtained at 500 {sup o}C was analysed and at this temperature the liquid product yield was the maximum. The various characteristics of bio-oil obtained under these conditions were identified on the basis of standard test methods. The empirical formula of the bio-oil with heating value of 31.8 MJ kg{sup -1} was established as CH{sub 1.65}O{sub 0.25}N{sub 0.03}. The chemical characterization showed that the bio-oil obtained from olive bagasse may be ...

2006-02-15

435

National and International Security Applications of Cryogenic Detectors - Mostly Nuclear Safeguards  

International Nuclear Information System (INIS)

As with science, so with security--in both arenas, the extraordinary sensitivity of cryogenic sensors enables high-confidence detection and high-precision measurement even of the faintest signals. Science applications are more mature, but several national and international security applications have been identified where cryogenic detectors have high potential payoff. International safeguards and nuclear forensics are areas needing new technology and methods to boost speed, sensitivity, precision and accuracy. Successfully applied, improved nuclear materials analysis will help constrain nuclear materials diversion pathways and contribute to treaty verification. Cryogenic microcalorimeter detectors for X-ray, gamma-ray, neutron, and alpha-particle spectrometry are under development with these aims in mind. In each case the unsurpassed energy resolution of microcalorimeters reveals previously invisible spectral features of nuclear materials. ...

2009-12-16

436

Modulating factors in the expression of radiation-induced oncogenic transformation  

Energy Technology Data Exchange (ETDEWEB)

Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitaive are also the least relevant in terms of human carcinogenesis and human risk estimation. The development of cell culture systems has made it possible to assess at the cellular level the oncogenic potential of a variety of chemical, physical and viral agents. Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals. Permissive and protective factors in radiation-induced transformation include thyroid hormone and the tumor promoter TPA that increase the transformation incidence for a given dose of radiation, and retinoids, selenium, vitamin E, and 5-aminobenzamide that ...

1990-08-01

437

Modulating factors in the expression of radiation-induced oncogenic transformation  

International Nuclear Information System (INIS)

Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitaive are also the least relevant in terms of human carcinogenesis and human risk estimation. The development of cell culture systems has made it possible to assess at the cellular level the oncogenic potential of a variety of chemical, physical and viral agents. Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals. Permissive and protective factors in radiation-induced transformation include thyroid hormone and the tumor promoter TPA that increase the transformation incidence for a given dose of radiation, and retinoids, selenium, vitamin E, and 5-aminobenzamide that ...

1990-01-01

438

Mixed waste landfill corrective measures study final report Sandia National Laboratories, Albuquerque, New Mexico.  

Energy Technology Data Exchange (ETDEWEB)

The Mixed Waste Landfill occupies 2.6 acres in the north-central portion of Technical Area 3 at Sandia National Laboratories, Albuquerque, New Mexico. The landfill accepted low-level radioactive and mixed waste from March 1959 to December 1988. This report represents the Corrective Measures Study that has been conducted for the Mixed Waste Landfill. The purpose of the study was to identify, develop, and evaluate corrective measures alternatives and recommend the corrective measure(s) to be taken at the site. Based upon detailed evaluation and risk assessment using guidance provided by the U.S. Environmental Protection Agency and the New Mexico Environment Department, the U.S. Department of Energy and Sandia National Laboratories recommend that a vegetative soil cover be deployed as the preferred corrective measure for the Mixed Waste Landfill. The cover would be of sufficient thickness to store precipitation, minimize infiltration and deep percolation, support a ...

2004-03-01

439

Methodology for designing air-quality-monitoring networks. 1. Theoretical aspects  

Energy Technology Data Exchange (ETDEWEB)

An objective methodology is presented for determining the number and disposition of ambient air-quality stations in a monitoring network for the primary purpose of compliance with air-quality standards. The methodology utilizes a data base with real or simulated data from an air quality dispersion model for application with a two-step process for ascertaining the optimal monitoring network. In the first step, the air-quality patterns in the data base are collapsed into a single composite pattern through a figure-of-merit (FOM) concept. The most-desirable locations are ranked and identified using the resultant FOM fields. In the second step the network configuration is determined on the basis of the concept of spheres of influence (SOI) developed from cutoff values of spatial-correlation coefficients between potential monitoring sites and adjacent locations. The minimum number of required stations is then determined by deletion of lower-ranked ...

1986-01-01

440

Material and process improvements in condenser tubing  

Energy Technology Data Exchange (ETDEWEB)

The reliability of the surface condenser is a key factor in plant performance level and maintenance cost optimization. This is especially the case for thermal nuclear plants where condenser raw wa-ter ingress can introduce contamination into the chemically-controlled, steam/water loop potentially causing damage to sensitive equipment. Two important parameters must be taken into account when attempting to optimize the quality and the reliability of condenser tubing. They include selecting the appropriate material according to the cooling water corrosion level present. A second and equally important parameter is the manufac-turing of the tubing product itself. This paper will identify methods to optimize manufacturing processes and improve tubing quality, according to VALTIMET's 30 years of condenser welded tubing production experience. Those methods complete the core manufacturing process (forming and welding), through improvement of ...

2010-07-01

441

MODFLOW 2.0: A program for predicting moderator flow patterns  

Energy Technology Data Exchange (ETDEWEB)

Sudden changes in the temperature of flowing liquids can result in transient buoyancy forces which strongly impact the flow hydrodynamics via flow stratification. These effects have been studied for the case of potential flow of stratified liquids to line sinks, but not for moderator flow in SRS reactors. Standard codes, such as TRAC and COMMIX, do not have the capability to capture the stratification effect, due to strong numerical diffusion which smears away the hot/cold fluid interface. A related problem with standard codes is the inability to track plumes injected into the liquid flow, again due to numerical diffusion. The combined effects of buoyant stratification and plume dispersion have been identified as being important in operation the Supplementary Safety System which injects neutron-poison ink into SRS reactors to provide safe shutdown in the event of safety rod failure. The MODFLOW code discussed here provides transient moderator ...

1991-07-01

442

MODFLOW 2. 0: A program for predicting moderator flow patterns  

Energy Technology Data Exchange (ETDEWEB)

Sudden changes in the temperature of flowing liquids can result in transient buoyancy forces which strongly impact the flow hydrodynamics via flow stratification. These effects have been studied for the case of potential flow of stratified liquids to line sinks, but not for moderator flow in SRS reactors. Standard codes, such as TRAC and COMMIX, do not have the capability to capture the stratification effect, due to strong numerical diffusion which smears away the hot/cold fluid interface. A related problem with standard codes is the inability to track plumes injected into the liquid flow, again due to numerical diffusion. The combined effects of buoyant stratification and plume dispersion have been identified as being important in operation the Supplementary Safety System which injects neutron-poison ink into SRS reactors to provide safe shutdown in the event of safety rod failure. The MODFLOW code discussed here provides transient moderator ...

1991-07-01

443

Isolation of fetal DNA from nucleated erythrocytes in maternal blood  

Energy Technology Data Exchange (ETDEWEB)

Fetal nucleated cells within maternal blood represent a potential source of fetal genes obtainable by venipuncture. The authors used monoclonal antibody against the transferrin receptor (TIR) to identify nucleated erythrocytes in the peripheral blood of pregnant women. Candidate fetal cells from 19 pregnancies were isolated by flow sorting at 12 1/2-17 weeks gestation. The DNA in these cells was amplified for a 222-base-pair (bp) sequence present on the short arm of the Y chromosome as proof that the cells were derived from the fetus. The amplified DNA was compared with standardized DNA concentrations. In the case of the female fetus, DNA prepared from samples at 32 weeks of gestation and cord blood at delivery also showed the presence of the Y chromosomal sequence, suggesting Y sequence mosaicism or translocation. In 10/12 cases where the 222-bp band was absent, the fetuses were female. Thus, they were successful in detecting the Y chromosomal ...

1990-05-01

444

Integrating Steel Production with Mineral Carbon Sequestration  

Energy Technology Data Exchange (ETDEWEB)

The objectives of the project were (i) to develop a combination iron oxide production and carbon sequestration plant that will use serpentine ores as the source of iron and the extraction tailings as the storage element for CO2 disposal, (ii) the identification of locations within the US where this process may be implemented and (iii) to create a standardized process to characterize the serpentine deposits in terms of carbon disposal capacity and iron and steel production capacity. The first objective was not accomplished. The research failed to identify a technique to accelerate direct aqueous mineral carbonation, the limiting step in the integration of steel production and carbon sequestration. Objective (ii) was accomplished. It was found that the sequestration potential of the ultramafic resource surfaces in the US and Puerto Rico is approximately 4,647 Gt of CO2 or over 500 years of current US production of CO2. Lastly, a computer model ...

2008-05-01

445

Inhibition of glypican-3 expression via RNA interference influences the growth and invasive ability of the MHCC97-H human hepatocellular carcinoma cell line.  

Science.gov (United States)

Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is found to be overexpressed in hepatocellular carcinoma (HCC). The purpose of the present study was to investigate the possible role of GPC3 in the development of HCC. In this study, RNA interference (RNAi) with a GPC3 small hairpin RNA (GPC3 shRNA) was used to identify the effects of GPC3 on the regulation of malignant behaviors of HCC. MHCC97-H, a highly metastatic human HCC cell line in which GPC3 mRNA and protein levels were detected as the highest among the 4 HCC cell lines assessed in this study, and was thus selected as a cell model for in vitro and in vivo experiments. The results showed that down-regulation of GPC3 can significantly inhibit the proliferative and invasive ability of MHCC97-H. Compared with the parental HCC cells, GPC3-silenced cells exhibited attenuated capacities in developing tumors in nude mice, while the growth of tumor xenografts derived from these cells dramatically ...

2011-05-20

446

INTRINSIC DOSIMETRY: A POTENTIAL NEW TOOL FOR NUCLEAR FORENSICS INVESTIGATIONS  

International Nuclear Information System (INIS)

Thermoluminescence (TL) dosimetry was used to measure dose effects on the raw stock material of borosilicate container glass from different geographical locations. Effects were studied at times up to 60 days post-irradiation at doses from 0.15 to 20 Gy. The minimum detectable dose using this technique was estimated to be 0.15 Gy which is roughly equivalent to a 24 hr irradiation 1 cm from a 50 ng source of 60Co. Two peaks were identified in the TL glow curve, a relatively unstable peak around 125 C and a more stable peak around 225 C. Differences in TL glow curve shape and intensity were also observed for the glasses from different geographical origins. We investigate radiation induced defects in glass to further develop the technique of intrinsic dosimetry - the measurement of the total absorbed dose received by the walls of a container holding radioactive material. Intrinsic dosimetry is intended to be used as an interrogation tool to provide enhanced pathway ...

2010-07-11

447

ICPP water inventory study project summary report  

Energy Technology Data Exchange (ETDEWEB)

The Idaho Chemical Processing Plant (ICPP) Water inventory Study was initiated in September 1993 with the formation of a joint working group consisting of representatives from DOE-ID, State of Idaho INEL Oversight Program, US Geological Survey, and INEL employees to investigate three issues that had been identified by the INEL Oversight Program at ICPP: (1) the water inventory imbalance at ICPP, (2) the source of water infiltrating into the Tank Farm vault sumps, and (3) the source of water providing potential recharge to perched water bodies underlying ICPP. These issues suggested that water was being lost from the ICPP distribution system. The INEL Oversight Program was concerned that the unaccounted for water at ICPP could be spreading contaminants that have been released over the past 40 years of operations of ICPP, possibly to the Snake River Plain Aquifer. This report summarizes the findings of each of the component investigations that ...

1994-01-01

448

High resolution sequence stratigraphy, sedimentology, petrology and reservoir potentials of the Glauconitic member in Westerose and adjacent fields, Alberta, Canada  

Energy Technology Data Exchange (ETDEWEB)

This thesis studied the petrology and sequence stratigraphy of the Hoadley barrier, a Glauconitic member in the Westerose field in Alberta. The unit contains gas reserves in an extensive northeast-southwest trending marine complex. A high resolution sequence stratigraphic model was used to understand the facies development of the unit and the diagenetic pathway of the strata. Six high frequency sequences were identified within the Glauconitic member. Each are separated from one another by surfaces of incision or subaerial exposure which sometimes coincide with a flooding surface and erosion. This thesis provided a petrographic characterization and depositional history of each of the 6 sequences. Reservoir quality is developed within the relatively quartz-rich foreshore facies of the G2B sandstones. The G3 chert litharenite to sublitharenite sandstones are excellent gas producers because of their coarser grain size and secondary porosity. The G4, G5 and G6 are ...

2002-07-01

449

High frequency limit of vacuum microelectronic grating free-electron laser  

International Nuclear Information System (INIS)

The dependencies that limit high frequency operation of a vacuum microelectronic grating free-electron laser are examined. The important parameters are identified as the electron beam energy, emittance, and generalized perveance. The scaling of power with emittance and frequency is studied in the far-infrared spectral range using a modified scanning electron microscope (SEM) and submillimeter diffraction gratings. The SEM is suited to the task of generating and positioning a low emittance (10"-"2#pi#-mm-mrad), low current (100 #mu#A), but high current density (50-500 A cm"-"2) electron beam. It has been used to demonstrate the spontaneous emission process known as the Smith-Purcell effect. A vacuum microelectronic grating free-electron laser has the potential of generating radiation throughout the entire far-infrared spectral range which extends from approximately 10 to 10"3#mu#m. An introduction to the theory, initial results, and details of ...

1995-08-21

450

FFTF fission gas monitor computer system  

International Nuclear Information System (INIS)

The Fast Flux Test Facility (FFTF) is a liquid-metal-cooled test reactor located on the Hanford site. A dual computer system has been developed to monitor the reactor cover gas to detect and characterize any fuel or test pin fission gas releases. The system acquires gamma spectra data, identifies isotopes, calculates specific isotope and overall cover gas activity, presents control room alarms and displays, and records and prints data and analysis reports. The fission gas monitor system makes extensive use of commercially available hardware and software, providing a reliable and easily maintained system. The design provides extensive automation of previous manual operations, reducing the need for operator training and minimizing the potential for operator error. The dual nature of the system allows one monitor to be taken out of service for periodic tests or maintenance without interrupting the overall system functions. A built-in calibrated ...

451

Evaluation of the potential of pentachlorophenol degradation in soil by pulsed corona discharge plasma from soil characteristics.  

Science.gov (United States)

Chlorinated organics are frequently found as harmful soil contaminants and persisted for extended periods of time. A novel approach, named pulsed corona discharge plasma (PCDP), was employed for the degradation of pentachlorophenol (PCP) in soil. Experimental results showed that 87% of PCP could be smoothly removed in 60 min. Increasing pulse voltage, enhancing soil pH, lowering humic acid (HA) in soil and reducing granular size of the soil were found to be favorable for PCP degradation efficiency. Oxidation and physical processes simultaneously contributed to PCP removal in soil and ozone was the main factor in PCDP treatment. C-Cl bonds in PCP were cleaved during PCDP treatment by Fourier transform infrared spectroscopy (FTIR) analysis. The mineralization of PCP was confirmed by total organic carbon (TOC) and dechlorination analyses. The main intermediate products such as tetrachlorocatechol, tetrachlorohydroquinone, acetic acid, formic acid, and oxalic acid were ...

2010-04-15

452

Evaluation of light-water-moderated, mixed-oxide, hexagonal pitch lattices  

International Nuclear Information System (INIS)

The use of previously measured mixed-oxide (MOX) fuel systems as benchmarks can be valuable tool in computational analysis and quality assurance efforts. The Fissile Materials Disposition Program (FMDP) has identified these experiments as potential benchmarks, or standards, for VVER's employing MOX fuel. Standards for the analysis of these benchmark experiments were based on those used in the recent compilation International Handbook of Evaluated Criticality Safety Benchmark Experiments begun in 1992 by the U.S. Department of Energy. The Los Alamos National Laboratory's archives were explored for log-book records of these experiments without success. These experiments were the first to use MOX fuel in light water. Three approach-to-critical experiments were performed using fuel rods at various pitches and different plutonium-oxide concentrations. A parallel program verified the prediction of critical condition as similar materials and ...

1997-11-16

453

Enhanced sludge washing evaluation plan  

Energy Technology Data Exchange (ETDEWEB)

The Tank Waste Remediation System (TWRS) Program mission is to store, treat, and immobilize highly radioactive Hanford Site waste (current and future tank waste and the strontium/cesium capsules) in an environmentally sound, safe, and cost-effective manner. The scope of the TWRS Waste Pretreatment Program is to treat tank waste and separate that waste into HLW and LLW fractions and provide additional treatment as required to feed LLW and HLW immobilization facilities. Enhanced sludge washing was chosen as the baseline process for separating Hanford tank waste sludge. Section 1.0 briefly discusses the purpose of the evaluation plan and provides the background that led to the choice of enhanced sludge washing as the baseline process. Section 2.0 provides a brief summary of the evaluation plan details. Section 3.0 discusses, in some detail, the technical work planned to support the evaluation of enhanced sludge washing. Section 4.0 briefly discusses the potential ...

1994-09-01

454

Ecotoxicology of Explosives  

Energy Technology Data Exchange (ETDEWEB)

Managing sites contaminated with munitions constituents is an international challenge. Although the choice of approach and the use of Ecological Risk Assessment (ERA) tools may vary from country to country, the assurance of quality and the direction of ecotoxicological research are universally recognized as shared concerns. Drawing on a multidisciplinary team of contributors, 'Ecotoxicology of Explosives' provides comprehensive and critical reviews available to date on fate, transport, and effects of explosives. The book delineates the state of the science of the ecotoxicology of explosives, past, present, and recently developed. It reviews the accessible fate and ecotoxicological data for energetic materials (EMs) and the methods for their development. The chapters characterize the fate of explosives in the environment, then provide information on their ecological effects in key environmental media, including aquatic, sedimentary, and terrestrial habitats. The book ...

2009-04-01

455

Economic evaluation of oil shale and tar sands resources located in the state of Utah. Phase I: final report  

Energy Technology Data Exchange (ETDEWEB)

Managing public lands for maximum social benefit is becoming an increasingly complex task. The growing need for domestically produced mineral raw materials and energy, and the conflicting interests over the use of public lands, have added new dimensions to the management issues. This report covers the first phase of a long-term program initiated by the Division of State Lands to improve their capability to evaluate the tar-sand and oil-shale resources in Utah. The scope of this phase of the study was limited to examination and analysis of existing information and to development models for data processing and resource evaluation. The study was effective in identifying problem areas and demonstrating the potential value of the proposed systems for management of state lands. It is anticipated that effective evaluation of the oil-shale and tar-sand resources in Utah, supported by readily accessible physical data, will lead to improved management ...

1981-03-01

456

Dynamic User-Defined Similarity Searching in Semi-Structured Text Retrieval  

CERN Document Server

Modern text retrieval systems often provide a similarity search utility, that allows the user to find efficiently a fixed number k of documents in the data set that are most similar to a given query (here a query is either a simple sequence of keywords or the identifier of a full document found in previous searches that is considered of interest). We consider the case of a textual database made of semi-structured documents. Each field, in turns, is modelled with a specific vector space. The problem is more complex when we also allow each such vector space to have an associated user-defined dynamic weight that influences its contribution to the overall dynamic aggregated and weighted similarity. This dynamic problem has been tackled in a recent paper by Singitham et al. in in VLDB 2004. Their proposed solution, which we take as baseline, is a variant of the cluster-pruning technique that has the potential for scaling to very large corpora of ...

2007-01-01

457

Determining the significance of environmental issues under the National Environmental Policy Act  

Energy Technology Data Exchange (ETDEWEB)

A fundamental problem facing those trying to comply with the National Environmental Policy Act (NEPA) centers around the word ''significantly''. Although the NEPA regulations discuss the term, they provide no clear definition of ''significance'' that can be applied objectively and uniformly to environmental issues and the consequences of man's activities. A major problem in trying to analyze environmental issues is caused by poor communication. The authors suggest common ''language'' for environmental analysis to organize and communicate information about environmental issues and impacts. An environmental issue is defined as an unresolved question or concern about an environmental consequence. Issues are analyzed using a simple worksheet that identifies who is concerned, what specific elements of the environment they are concerned about, and why they ...

1984-01-01

458

Critical review of studies on atmospheric dispersion in coastal regions  

Energy Technology Data Exchange (ETDEWEB)

This study effort was required as a preliminary step prior to initiation of field measurements of atmospheric dispersion in coastal regions. The Nuclear Regulatory Commission (NRC) is in the process of planning an extensive field measurement program to generate data which will serve as improved data bases for licensing decisions, confirmation of regulations, standards, and guides, and for site characterizations. The study being reported here is an effort directed to obtaining as much information as is possible from existing studies that is relevant toward NRC's objectives. For this study, reports covering research and meteorological measurements conducted for industrial purposes, utility needs, military objectives, and academic studies were obtained and critically reviewed in light of NRC's current data needs. This report provides an interpretation of the extent of existing usable information, an indication of the potential for tailoring existing ...

1982-09-01

459

Cooperative measures to mitigate Asia-Pacific maritime conflicts.  

Energy Technology Data Exchange (ETDEWEB)

The economies of East Asia are predominantly export based and, therefore, place special emphasis on the security of the sea lines of communication (SLOCs). Due to economic globalization, the United States shares these concerns. Cooperative measures by the concerned parties could reduce the potential for disruption by maritime conflicts. Primary threats against the SLOCs are disputes over the resources under the seas, disputes over some small island groups, disputes between particular parties (China-Taiwan and North-South Korea), or illegal activities like smuggling, piracy, or terrorism. This paper provides an overview on these threats, issue by issue, to identify common elements and needed cooperation. Cooperation on other topics such as search and rescue, fisheries protection, and oil spill response may help support improved relations to prevent maritime conflicts. Many technologies can help support maritime cooperation, including improved ...

2003-05-01

460

Continuation application for the Amarillo National Resource Center for Plutonium, a higher education consortium consisting of Texas A and M University, Texas Tech University, and the University of Texas at Austin  

Energy Technology Data Exchange (ETDEWEB)

This report describes the 5 tasks to be covered under this project and compiles budget information. Task 1 is to establish a Plutonium Information Resource, which has been established in Amarillo, Texas. Task 2, Advisory Functions, coordinates studies and activities relating to the disposition of excess weapons-grade plutonium. Task 3, Environmental, Public Health, and Safety, supports soil remediation activities. Task 4, Education and Outreach, is supporting four programs: K--12 education improvement in science and math courses; Academic intervention to identify and encourage high ability high school and middle school students with potential to become scientists and engineers; Graduate education evaluation; and Public outreach programs. Task 5, Plutonium and other Materials Studies, is currently funding two projects for the disposition of high explosives: a feasibility study of burning a mixture of high explosives and other materials in a ...

1995-06-29

461

Conceptual design of a hydrogen production system by DME steam reforming and high-efficiency nuclear reactor technology  

International Nuclear Information System (INIS)

Hydrogen is a potential alternative energy source and produced commercially by methane (natural gas) or LPG steam reforming, a process that requires high temperatures, which are produced by burning fossil fuels. However, since this process emits large amounts of CO_2, replacement of the combustion heat source with a nuclear heat source for 773-1173 K processes has been proposed in order to eliminate these CO_2 emissions. This paper proposes a novel method of low-temperature nuclear hydrogen production by reforming dimethyl ether (DME) with steam produced by a low-temperature nuclear reactor at about 573 K. The authors identified conditions that provide high hydrogen production fraction at low pressure and temperatures of about 523-573 K. By setting this low-temperature hydrogen production process at about 573K upstream from a turbine, it was found theoretically that the total energy utilization efficiency is about 50% and very high. By setting ...

2003-09-15

462

Comparison between NIR, MIR, concatenated NIR and MIR analysis and hierarchical PLS model. Application to virgin olive oil analysis.  

Science.gov (United States)

This work investigates the potential use of simultaneously near-infrared (NIR) and mid-infrared (MIR) spectroscopies for the quantitative analysis of fatty acids and triacylglycerols and for identifying the Registered Designation of Origin (RDO) of extra virgin olive oils. The two spectral ranges were used separately using PLS and PLS-DA regressions. To combine both information, concatenated matrix was used at the first time, multiblock method using H-PLS models were constructed at the second time. The models were compared in terms of prediction errors. The results obtained with MIR spectroscopy are better than the ones obtained with NIR spectroscopy. The H-PLS methodology seems to be very interesting for quantitative analysis with the use of additional information in the NIR range, which is not present in the MIR one. For RDO identification by discriminant analysis, the use of multiblock method was less efficient. PMID:20433960

2010-03-29

463

Cavitation guide for control valves  

Energy Technology Data Exchange (ETDEWEB)

This guide teaches the basic fundamentals of cavitation to provide the reader with an understanding of what causes cavitation, when it occurs, and the potential problems cavitation can cause to a valve and piping system. The document provides guidelines for understanding how to reduce the cavitation and/or select control valves for a cavitating system. The guide provides a method for predicting the cavitation intensity of control valves, and how the effect of cavitation on a system will vary with valve type, valve function, valve size, operating pressure, duration of operation and details of the piping installation. The guide defines six cavitation limits identifying cavitation intensities ranging from inception to the maximum intensity possible. The intensity of the cavitation at each limit Is described, including a brief discussion of how each level of cavitation influences the valve and system. Examples are included to demonstrate how to ...

1993-04-01

464

Boron-Lined Neutron Detector Measurements  

Energy Technology Data Exchange (ETDEWEB)

Radiation portal monitors used for interdiction of illicit materials at borders include highly sensitive neutron detection systems. The main reason for having neutron detection capability is to detect fission neutrons from plutonium. The currently deployed radiation portal monitors (RPMs) from Ludlum and Science Applications International Corporation (SAIC) use neutron detectors based upon 3He-filled gas proportional counters, which are the most common large neutron detector. There is a declining supply of 3He in the world, and thus, methods to reduce the use of this gas in RPMs with minimal changes to the current system designs and sensitivity to cargo-borne neutrons are being investigated. Four technologies have been identified as being currently commercially available, potential alternative neutron detectors to replace the use of 3He in RPMs. Reported here are the results of tests of a newly designed boron-lined proportional counter option. ...

2009-11-02

465

Assessment of energy potential from biomass in Louisiana. Final report  

Energy Technology Data Exchange (ETDEWEB)

The objective of this project is to identify feasible Louisiana-grown biomass crops and residues, to combine these with technically and economically feasible conversion processes, and to provide integrated biomass energy production systems in Louisiana. Among the recommended integrated systems are: cotton gin trash and rice hull processing residues used for either direct combustion or methane or ethanol production. Steam generation via direct combustion is recommended. Hardwood chips are economically feasible despite considerable price and supply instability, while high sugar or starch content crops are easily converted to ethanol but limited by price. Possible breakthroughs in biomass production or in the hydrolysis of starch or cellulose substrates may decrease processing costs. Recommended areas for future study dealing with production include: (1) increase biomass availability and density; (2) increase harvesting, transportation and storage technologies; (3) ...

1983-12-01

466

An investigation of the production of thin films of some materials which undergo phase transitions for optical applications  

CERN Document Server

The aim of this work was to study the possibility of producing a fast switching optical thin film device to react to laser radiation in the visible/near infrared region of the spectrum. The switching mechanism was to be thermally driven. A computer program was written to enable the effects of changes of the refractive index of a component of a multilayer thin film stack to be modelled. Attempts to use the phase transition in vanadium dioxide were unsuccessful because, in the spectral region of interest, the 'open-state' absorption was too great. A class of materials known as 'the bronzes' was identified as being potentially useful. Attempts were made to produce thin films of bronze compounds of vanadium, tungsten and molybdenum by the techniques of conventional thermal evaporation and laser ablation for further studies. The former technique appeared to suffer from problems of decomposition of the source material. The latter technique showed ...

1995-01-01

467

Accelerator driven assembly  

Energy Technology Data Exchange (ETDEWEB)

This report addresses a Los Alamos National Laboratory (LANL) proposal to build a pulsed neutron source for simulating nuclear-weapons effects. A point design for the pulsed neutron facility was initiated early in FY94 after hosting a Defense Nuclear Agency (DNA) panel review and after subsequently visiting several potential clients and users. The technical and facility designs contained herein fulfill the Statement of Work (SOW) agreed upon by LANL and DNA. However, our point designs and parametric studies identify a unique, cost-effective, above-ground capability for neutron nuclear-weapons-effects studies at threat levels. This capability builds on existing capital installations and infrastructure at LANL. We believe that it is appropriate for us, together with the DNA, to return to the user community and ask for their comments and critiques. We also realize that the requirements of last year have changed significantly. Therefore, the ...

1997-01-01

468

Abundance of West Nile virus mosquito vectors in relation to climate and landscape variables.  

Science.gov (United States)

It is currently unclear if the potential for West Nile virus transmission by mosquito vectors in the eastern United States is related to landscape or climate factors or both. We compared abundance of vector species between urban and suburban neighborhoods of Henrico County, VA, in relation to the following factors: temperature, precipitation, canopy cover, building footprint, and proximity to drainage infrastructure. Mosquitoes were collected throughout the 2005, 2006, and 2007 seasons and tested for West Nile virus (WNV) in pools of 10-50. Test results of mosquito pools were compared to average site abundance from 37 sites in Henrico County, VA; abundance was then examined in relation to ecological variables. Urban infrastructure was positively correlated with the abundance of Culex pipiens L./Cx. restuans, and our findings implicate combined sewer overflow systems as large contributors to Culex vector populations. No measure of urbanization examined in our study ...

2011-06-01

469

A carbon monoxide passive sampler: Research and development needs  

Energy Technology Data Exchange (ETDEWEB)

In rare instances, carbon monoxide (CO) levels in houses can reach dangerously high concentrations, causing adverse health effects ranging from mild headaches to, under extreme conditions, death. Hundreds of fatal accidental carbon monoxide poisonings occur each year primarily due to the indoor operation of motor vehicles, the indoor use of charcoal for cooking, the operation of malfunctioning vented and unvented combustion appliances, and the misuse combustion appliances. Because there is a lack of simple, inexpensive, and accurate field sampling instrumentation, it is difficult for gas utilities and researchers to conduct field research studies designed to quantify the concentrations of CO in residences. Determining the concentration of CO in residences is the first step towards identifying the high risk appliances and high-CO environments which pose health risks. Thus, there exists an urgent need to develop and field-validate a CO-quantifying technique suitable ...

1991-11-01

470

A PC-based software package for modeling DOE mixed-waste management options  

Energy Technology Data Exchange (ETDEWEB)

The U.S. Department of Energy (DOE) Headquarters and associated contractors have developed an IBM PC-based software package that estimates costs, schedules, and public and occupational health risks for a range of mixed-waste management options. A key application of the software package is the comparison of various waste-treatment options documented in the draft Site Treatment Plans prepared in accordance with the requirements of the Federal Facility Compliance Act of 1992. This automated Systems Analysis Methodology consists of a user interface for configuring complexwide or site-specific waste-management options; calculational algorithms for cost, schedule and risk; and user-selected graphical or tabular output of results. The mixed-waste management activities modeled in the automated Systems Analysis Methodology include waste storage, characterization, handling, transportation, treatment, and disposal. Analyses of treatment options identified in the draft Site ...

1995-02-01

471

BMFT. The 'biotechnology 2000' project. Annual report 1991. BMFT. Programm Biotechnologie 2000. Jahresbericht 1991  

Energy Technology Data Exchange (ETDEWEB)

The ''biotechnology 2000'' project is supervised by the project sponsor ''biology, energy, ecology'' at Forschungszentrum Juelich on behalf of the Federal Ministry for Research and Technology. The project activities cover the development of techniques and methods, cell biology, gene structure and gene regulation, photosynthetic production processes, biological hydrogen production, synthetic biology, protein design, neurobiological research, biosystems, plant breeding, phytomedicine and plant protection, the biology of waste disposal methods, research into methods which replace animal experiments, biological safety research, technology risk assessment, and ethical aspects. A general survey introduces the promoted projects, and standardized data sheets briefly introduce the individual ...

1992-01-01

472

Structure, reactivity, and biological properties of hidantoines; Estrutura, reatividade e propriedades biologicas de hidantoinas  

Energy Technology Data Exchange (ETDEWEB)

Hydantoin (imidazolidine-2,4-dione) is a 2,4-diketotetrahydroimidazole discovered by Baeyer in 1861. Thiohydantoins and derivatives were prepared, having chemical properties similar to the corresponding carbonyl compounds. Some biological activities (antimicrobial, anticonvulsant, schistosomicidal) are attributed to the chemical reactivity and consequent affinity of hydantoinic rings towards biomacromolecules. Therefore, knowledge about the chemistry of hydantoins has increased enormously. In this review, we present important aspects such as reactivity of hydantoins, acidity of hydantoins, spectroscopy and crystallographic properties, and biological activities of hydantoin and its derivatives. (author)

2008-07-01

473

Confocal Imaging of Biological Tissues Using Second Harmonic Generation  

Energy Technology Data Exchange (ETDEWEB)

A confocal microscopy imaging system was devised to selectively detect Second harmonic signals generated by biological tissues. Several types of biological tissues were examined using this imaging system, including human teeth, bovine blood vessels, and chicken skin. All these tissues generated strong second harmonic signals. There is considerable evidence that the source of these signals in tissue is collagen. Collagen, the predominant component of most tissues, is known to have second order nonlinear susceptibility. This technique may have diagnostic usefulness in pathophysiological conditions characterized by changes in collagen structure including malignant transformation of nevi, progression of diabetic complications, and abnormalities in wound healing.

2000-03-06

474

Advances in molecular biology: impact on rotavirus vaccine development.  

Science.gov (United States)

The first candidate rotavirus vaccine was a live attenuated oral vaccine made by the classical empirical method of serial passage of virus in tissue culture cells. Current tetravalent vaccine candidates that are in the final stages of efficacy testing in the United States were made by genetic reassortment. This article briefly highlights how advances in the basic understanding of the molecular biology of rotaviruses have facilitated vaccine development. New approaches for second-generation vaccines and improvements in vaccine efficacy based on further exploitation of the tools and knowledge of rotavirus molecular biology and pathogenesis are discussed. PMID:8752289

1996-09-01

475

Using benchmarking to minimize common DOE waste streams: Volume 5. Office paper waste  

Energy Technology Data Exchange (ETDEWEB)

Finding innovative ways to reduce waste streams generated at US Department of Energy (DOE) sites by 50% by the year 2000 is a challenge for DOE`s waste minimization efforts. A team composed of members from several DOE facilities used the quality tool known as benchmarking to improve waste minimization efforts. First the team examined office waste generation and handling processes at their sites. Then team members developed telephone and written questionnaires to help identify potential ``best-in-class`` industry partners willing to share information about their best waste minimization techniques and technologies. The team identified two benchmarking partners, NIKE, Inc., in Beaverton, Oregon, and Microsoft, Inc., in Redmond, Washington. Both companies have proactive, employee-driven environmental issues programs. Both companies report strong employee involvement, management commitment, and readily available markets for ...

1995-10-01

476

The geological structures of gas hydrate occurrence in big gas field of the northern slope of South China Sea  

Energy Technology Data Exchange (ETDEWEB)

The passive continental margin in the northern South China Sea is a weakly active area. It has been found to be favorable for large gas field development and also to be profitable for gas hydrate. The active faults, diapir structure, slump deposits, faults break of slopes, gas chimneys and sandstone of submarine fan, control the concentration of gas hydrate. Gas chimneys are widely distributed in the northern South China Sea. They supply the pathway for migration of deeper gas to gas hydrate stability zones especially in the basin of tectonic inactive zone. This paper discussed the geological structures of gas hydrate occurrence in gas fields and presented a detailed analysis of gas chimneys within the northern slope of the South China Sea. The paper described the geological setting of the Qiongdongnan Basin and provided information on the data description and processing. Two multichannel seismic (MCS) reflection profiles were used for the study. In order to ...

2008-07-01

477

Strategic Energy Planning (Area 1) Consultants Reports to Citizen Potawatomi Nation Federally Recognized Indian Tribe  

Energy Technology Data Exchange (ETDEWEB)

The assets that Citizen Potawatomi Nation holds were evaluated to help define the strengths and weaknesses to be used in pursuing economic prosperity. With this baseline assessment, a Planning Team will create a vision for the tribe to integrate into long-term energy and business strategies. Identification of energy efficiency devices, systems and technologies was made, and an estimation of cost benefits of the more promising ideas is submitted for possible inclusion into the final energy plan. Multiple energy resources and sources were identified and their attributes were assessed to determine the appropriateness of each. Methods of saving energy were evaluated and reported on and potential revenue-generating sources that specifically fit the tribe were identified and reported. A primary goal is to create long-term energy strategies to explore development of tribal utility options and analyze renewable energy and energy ...

2004-12-01

478

Power Tower Technology Roadmap and cost reduction plan.  

Energy Technology Data Exchange (ETDEWEB)

Concentrating solar power (CSP) technologies continue to mature and are being deployed worldwide. Power towers will likely play an essential role in the future development of CSP due to their potential to provide dispatchable solar electricity at a low cost. This Power Tower Technology Roadmap has been developed by the U.S. Department of Energy (DOE) to describe the current technology, the improvement opportunities that exist for the technology, and the specific activities needed to reach the DOE programmatic target of providing competitively-priced electricity in the intermediate and baseload power markets by 2020. As a first step in developing this roadmap, a Power Tower Roadmap Workshop that included the tower industry, national laboratories, and DOE was held in March 2010. A number of technology improvement opportunities (TIOs) were identified at this workshop and separated into four categories associated with power tower subsystems: solar ...

2011-04-01

479

Ocean FUSRAP: feasibility of ocean disposal of materials from the Formerly Utilized Sites Remedial Action Progam (FUSRAP)  

Energy Technology Data Exchange (ETDEWEB)

The Formerly Utilized Sites Remedial Action Program (FUSRAP) of the Department of Energy is designed to identify and evaluate the radiological conditions at sites formerly used by the Corps of Engineers Manhattan Engineer District and the US Atomic Energy Commission. Where required, remedial action will be instituted to remove potential restrictions on the use of the sites due to residual low-level radioactive contamination. A total of 31 sites that may require remedial action has been identified. The purpose of the Ocean FUSRAP Program, which began in March 1981, is to assess the technical, environmental, and institutional feasibility of disposing, in the ocean and on the ocean floor, of FUSRAP soil and rubble which contains traces of natural radioactive materials. The initial focus has been on the Middlesex, New Jersey, Sampling Plant site and surrounding properties, which contain on the order of 100,000 metric tons of ...

1982-01-01

480

Ocean FUSRAP: feasibility of ocean disposal of materials from the Formerly Utilized Sites Remedial Action Progam (FUSRAP)  

International Nuclear Information System (INIS)

The Formerly Utilized Sites Remedial Action Program (FUSRAP) of the Department of Energy is designed to identify and evaluate the radiological conditions at sites formerly used by the Corps of Engineers Manhattan Engineer District and the US Atomic Energy Commission. Where required, remedial action will be instituted to remove potential restrictions on the use of the sites due to residual low-level radioactive contamination. A total of 31 sites that may require remedial action has been identified. The purpose of the Ocean FUSRAP Program, which began in March 1981, is to assess the technical, environmental, and institutional feasibility of disposing, in the ocean and on the ocean floor, of FUSRAP soil and rubble which contains traces of natural radioactive materials. The initial focus has been on the Middlesex, New Jersey, Sampling Plant site and surrounding properties, which contain on the order of 100,000 metric tons of ...

481

Investigation of a mercury speciation technique for flue gas desulfurization materials.  

Science.gov (United States)

Most of the synthetic gypsum generated from wet flue gas desulfurization (FGD) scrubbers is currently being used for wallboard production. Because oxidized mercury is readily captured by the wet FGD scrubber, and coal-fired power plants equipped with wet scrubbers desire to benefit from the partial mercury control that these systems provide, some mercury is likely to be bound in with the FGD gypsum and wallboard. In this study, the feasibility of identifying mercury species in the FGD gypsum and wallboard samples was investigated using a large sample size thermal desorption method. Potential candidates of pure mercury standards including mercuric chloride (HgCl2), mercurous chloride (Hg2Cl2), mercury oxide (HgO), mercury sulfide (HgS), and mercuric sulfate (HgSO4) were analyzed to compare their results with those obtained from FGD gypsum and dry wallboard samples. Although any of the thermal evolutionary curves obtained from these pure mercury ...

2009-08-01

482

High temperature electrochemical polishing of H{sub 2}S from coal gasification process streams. Quarterly progress report, January 1, 1996--March 31, 1996  

Energy Technology Data Exchange (ETDEWEB)

Coal may be used to generate electrical energy by any of several processes, most of which involve combustion or gasification. Combustion in a coal-fired boiler and power generation using a steam- cycle is the conventional conversion method; however, total energy conversion efficiencies for this type of process are only slightly over 30{percent}. Integration of a gas-cycle in the process (combined cycle) may increase the total conversion efficiency to 40{percent}. Conversion processes based on gasification offer efficiencies above 50{percent}. H{sub 2}S is the predominant gaseous contaminant in raw coal gas. Problems arise due to the corrosive nature of H{sub 2}S on metal components contained in these cycles. Because of this, H{sub 2}S concentrations must be reduced to low levels corresponding to certain power applications. An advanced process for the separation of hydrogen sulfide (H{sub 2}S) from coal gasification product streams through an electrochemical membrane is being developed ...

1996-09-01

483

Factors affecting public and political acceptance for the implementation of geological disposal  

International Nuclear Information System (INIS)

This publication identifies conditions which affect (either increase or decrease) public concern for and political acceptance of the development and implementation of programmes for geological disposal of long lived radioactive waste. It also looks at how interested citizens can be associated in the decision making process in such a way that their input enriches the outcome of a more socially robust and sustainable solution. The publication also considers how to optimize risk management, addressing the needs and expectations of the public and of other relevant stakeholders. Factors of relevance for societal acceptance conditions are identified for the different stages of a repository programme and implementation process, from policy development to the realization of the repository itself. Further, they are described and analysed through case studies from several countries, illustrating the added value of broadening the technical dimension with ...

2009-09-01

484

FFTF [Fast Flux Test Facility] Fission Gas Monitor Computer System  

International Nuclear Information System (INIS)

The Fast Flux Test Facility (FFTF) is a liquid-metal-cooled, fast neutron test reactor located on the Hanford Site. A dual computer system has been developed to monitor the reactor cover gas to detect and characterize any fuel or test pin fission gas releases. The system acquires gamma spectra data, identifies isotopes, calculates specific isotope and overall cover gas activity, presents control room alarms and displays, and records and prints data and analysis reports. The Fission Gas Monitor System (FGMS) integrates commercially available hardware and software, providing a reliable and easily maintained system. The design provides extensive automation of previous manual operations, reducing the need for operator training and minimizing the potential for operator error. The dual nature of the system allows either system A or B to be taken out of service for periodic tests or maintenance without interrupting the overall system performance. A ...

485

ERK-dependent and -independent pathways trigger human neural progenitor cell migration  

International Nuclear Information System (INIS)

Besides differentiation and apoptosis, cell migration is a basic process in brain development in which neural cells migrate several centimeters within the developing brain before reaching their proper positions and forming the right connections. For identifying signaling events that control neural migration and are therefore potential targets of chemicals to disturb normal brain development, we developed a human neurosphere-based migration assay based on normal human neural progenitor (NHNP) cells, in which the distance is measured that cells wander over time. Applying this assay, we investigated the role of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the regulation of NHNP cell migration. Exposure to model substances like ethanol or phorbol 12-myristate 13-acetate (PMA) revealed a correlation between ERK1/2 activation and cell migration. The participation of phospho-(P-) ERK1/2 was confirmed by exposure of the cells to the ...

2007-05-15

486

Construction of the Savannah River Ecology Laboratory Conference Center  

International Nuclear Information System (INIS)

This Environmental Assessment (EA) reviews the environmental consequences associated with the proposed action of granting a site use permit to construct and operate a conference center on an approximately 70-acre tract of land on the Savannah River Site (SRS). While the proposed action requires an administrative decision by DOE, this EA reviews the linked action of physically constructing and operating a conference center. The SRS is a DOE-owned nuclear production facility encompassing approximately 200,000 acres in southwestern South Carolina. The proposed conference center would have an area of approximately 4,000 square feet, and would infrequently accommodate as many as 150 people, with the average being about 20 people per day. In addition to the No-Action alternative, under which the Research Foundation would not require the 70-acre tract of SRS land for a conference center, this EA considers site preservation. Under Site Preservation only minimal activities necessary to the SRS ...

2006-05-15

487

Comparison of helmet-mounted display designs in support of infantry wayfinding  

Science.gov (United States)

The Canadian Soldier Information Requirements Technology Demonstration (SIREQ TD) soldier modernization research and development program has conducted experiments to help determine the types and amount of information needed to support wayfinding across a range of terrain environments, the most effective display modality for providing the information (visual, auditory or tactile) that will minimize conflict with other infantry tasks, and to optimize interface design. In this study, seven different visual helmet-mounted display (HMD) designs were developed based on soldier feedback from previous studies. The displays and an in-service compass condition were contrasted to investigate how the visual HMD interfaces influenced navigation performance. Displays varied with respect to their information content, frame of reference, point of view, and display features. Twelve male infantry soldiers used all eight experimental conditions to locate bearings to waypoints. From a constant location, ...

2003-09-01

488

Characteristics of the Receptor for the Biosphere Model  

Energy Technology Data Exchange (ETDEWEB)

This analysis report is one of a series of technical reports that document the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the total system performance assessment (TSPA) for the geologic repository at Yucca Mountain. This report is one of the five biosphere reports that develop input parameter values for the biosphere model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes the conceptual model, as well as the mathematical model and its input parameters. Figure 1-1 is a graphical representation of the documentation hierarchy for the ERMYN. This figure shows relationships among the products (i.e., scientific analyses and model reports) developed for biosphere modeling and biosphere abstraction products for TSPA, as identified in the ''Technical Work Plan: for Biosphere Modeling and Expert Support'' (BSC 2004 [DIRS 169573]). The ...

2004-09-09

489

Characterisation of dust material emitted during harbour operations (HADA Project)  

Energy Technology Data Exchange (ETDEWEB)

The aim of this work is to compile an inventory of the main characteristics (chemical, morphological, mineralogical and grain size parameters) of the bulk cargo materials and of the material emitted during different port operations for possible use as tracers of the fugitive PM emission sources. For all cases, the tracer characteristics determined for each bulk material were also identified in the corresponding PM material emitted. This inventory could assist the harbour authorities to identify the origin of high PM events recorded by air quality monitoring networks in harbour areas, and could also help modellers to predict the impact of harbour activities on ambient PM levels. The harbour of Tarragona (north-east Spain) was selected for this study given the high volume of solids in bulk handled. To this end, 12 handling operations of selected materials (clinker, phosphate, pyrite ash, Mn mineral, fine Si-Mn, coke (coal), bituminous coal, ...

2007-09-15

490

APSTNG: Neutron interrogation for detection of nuclear and CW weapons, explosives, and drugs  

Energy Technology Data Exchange (ETDEWEB)

A recently developed neutron diagnostic probe system has the potential to satisfy a significant number of van-mobile and fixed- portal requirements for nondestructive verification of sealed munitions and detection of contraband explosives and drugs. The probe is based on a unique associated-particle sealed-tube neutron generator (APSTNG) that interrogates the object of interest with a low-intensity beam of 14-MeV neutrons generated from the deuterium-tritium reaction and that detects the alpha-particle associated with each neutron. Gamma-ray spectra of resulting neutron inelastic scattering and fission reactions identify nuclides associated with all major chemicals in chemical warfare agents, explosives, and drugs, as well as many pollutants and fissile and fertile special nuclear material. Flight times determined from determined from detection times of the gamma-rays and alpha-particles yield a separate tomographic image of each ...

1992-07-01

491

AIRBORNE, OPTICAL REMOTE SENSING OF METHANE AND ETHANE FOR NATURAL GAS PIPELINE LEAK DETECTION  

Energy Technology Data Exchange (ETDEWEB)

Ophir Corporation was awarded a contract by the U. S. Department of Energy, National Energy Technology Laboratory under the Project Title ''Airborne, Optical Remote Sensing of Methane and Ethane for Natural Gas Pipeline Leak Detection'' on October 14, 2002. This second six-month technical report summarizes the progress made towards defining, designing, and developing the hardware and software segments of the airborne, optical remote methane and ethane sensor. The most challenging task to date has been to identify a vendor capable of designing and developing a light source with the appropriate output wavelength and power. This report will document the work that has been done to identify design requirements, and potential vendors for the light source. Significant progress has also been made in characterizing the amount of light return available from a remote target at various distances from ...

2003-11-12

492

A large surface neutron and photon detector for civil security applications  

Energy Technology Data Exchange (ETDEWEB)

The security of ports and transportation is of utmost importance for the development of economy and the security of a nation. Among the necessary actions to ensure the security of ports and borders, the inspection of containers is one of the most time consuming and expensive procedures. Potential threats are the illegal traffic of radioactive materials that could be employed for the construction of weapons, as uranium and plutonium. New techniques for the inspections of containers should be fast, allow the detection and identification of dangerous materials, and be non-invasive, to reduce costs and delays. We propose to build a large surface photon and neutron detector based on plastic scintillator to identify the presence of fissile or fertile material inside a container. The detector consists of scintillator bars, wrapped in thin foils of reflecting material containing gadolinium for neutron capture and arranged in planes separated by ...

2010-05-21

493

A large surface neutron and photon detector for civil security applications  

International Nuclear Information System (INIS)

The security of ports and transportation is of utmost importance for the development of economy and the security of a nation. Among the necessary actions to ensure the security of ports and borders, the inspection of containers is one of the most time consuming and expensive procedures. Potential threats are the illegal traffic of radioactive materials that could be employed for the construction of weapons, as uranium and plutonium. New techniques for the inspections of containers should be fast, allow the detection and identification of dangerous materials, and be non-invasive, to reduce costs and delays. We propose to build a large surface photon and neutron detector based on plastic scintillator to identify the presence of fissile or fertile material inside a container. The detector consists of scintillator bars, wrapped in thin foils of reflecting material containing gadolinium for neutron capture and arranged in planes separated by ...

2010-05-11

494

New Developments in the Use of Histamine and Histamine Receptors  

UK PubMed Central (United Kingdom)

Histamine and the histamine receptors are important regulators of a plethora of biological processes, including immediate hypersensitivity reactions and acid secretion in the stomach. In these...Full Text Available

2011-04-01

495

Biological Studies of Bagous Hydrillae  

Science.gov (United States)

... Ceratophyllaceas Ceratophyllum doemesm 96 4 3 4 107 Convulivulacme Ipomea aquatica 13 13 Haloragaceae Myriophyflum trahycatpum 15 15 ...

1994-09-01

496

Allozyme Divergence in Two Syntopic Liolaemus of the Liolaemus monticola Group (Squamata: Tropiduridae)  

Science.gov (United States)

... shareware for population genetic analysis. Molecular Biology and Biotecnology Centre, Univ. of Alberta, Canada. enlarge figure Fig. ... ...