WorldWideScience
1

Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila  

UK PubMed Central (United Kingdom)

A multiple comparison approach using whole genome transcriptional arrays was used to identify genes and pathways involved in calorie restriction/dietary restriction (DR) life span extension in Drosophila....Full Text Available

2011-03-15

2

Life history plasticity after attaining a dietary threshold for reproduction is associated with protein storage in flesh flies  

UK PubMed Central (United Kingdom)

SummaryBody condition affects the timing and magnitude of life history transitions. Therefore, identifying proximate mechanisms...Full Text Available

2008-12-01

3

Diet and incident venous thromboembolism: The Iowa Women's Health Study  

British Library Electronic Table of Contents (United Kingdom)

Background Little is known about the role of diet in the development of venous thromboembolism (VTE). We explored the prospective relation of dietary patterns, food groups, and nutrients to incident VTE in older women. Methods In 1986, Iowa women aged 55 to 69 years completed a mailed survey, including a 127-item food frequency questionnaire. These data were linked to Medicare data from 1986 to 2004, and International Classification of Diseases discharge codes were used to identify hospitalized VTE cases. Cox regression analyses evaluated relations of 2 principal components?derived dietary patterns, 11 food groups, and 6 nutrients to VTE, adjusted for age, education, smoking status, physical activity, and energy intake. Results Over 19 years of follow-up, 1,950 of the 37,393 women develope...

2009-01-01

4

Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?  

UK PubMed Central (United Kingdom)

Lifespan can be extended by reduction of dietary intake. This practice is referred to as dietary restriction (DR), and extension of lifespan by DR is evolutionarily conserved in taxonomically diverse...Full Text Available

2007-04-01

7

Dietary Glycaemic Index, Dietary Glycaemic Load, and Incidence of Myocardial Infarction in Women  

UK PubMed Central (United Kingdom)

The association of dietary glycaemic index (GI) and glycaemic load (GL) with cardiovascular diseases has been examined in several populations with varying results. We tested the hypothesis that...Full Text Available

2010-04-01

8

Dietary Phosphorus Acutely Impairs Endothelial Function  

UK PubMed Central (United Kingdom)

Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease, but the mechanisms underlying this risk are not completely understood....Full Text Available

2009-07-01

9

Dietary Lipids, Cells Adhesion and Breast Cancer Metastasis  

Science.gov (United States)

... Accession Number : ADA396364. Title : Dietary Lipids, Cells Adhesion and Breast Cancer Metastasis. Descriptive Note : Annual rept. ...

2000-10-01

10

Astaxanthin reduces ischemic brain injury in adult rats  

UK PubMed Central (United Kingdom)

Astaxanthin (ATX) is a dietary carotenoid of crustaceans and fish that contributes to their coloration. Dietary ATX is important for development and survival of salmonids and crustaceans and has been...Full Text Available

2009-06-01

11

Impact of Invasive Cane Toads on Australian Birds  

British Library Electronic Table of Contents (United Kingdom)

Abstract: The cane toad (Bufo marinus), a large, toxic, American anuran, was introduced to Australia in 1935. Populations of many of Australia's reptiles (snakes, varanid lizards, crocodiles) and carnivorous mammals (dasyurid marsupials) have declined because these predators are killed by the toad's powerful toxins. In contrast to these well-studied species, little is known about the cane toads impacts on Australian birds. We reviewed published and unpublished data on behavioral interactions between Australian avian predators and cane toads and collated distributional and dietary information to identify avian taxa potentially at risk from cane toad invasion. Cane toads are sympatric with 172 frog-eating bird species in Australia, and an additional 8 bird species overlap with the predicted ...

2009-01-01

21

Toward Dietary Assessment via Mobile Phone Video Cameras  

UK PubMed Central (United Kingdom)

Reliable dietary assessment is a challenging yet essential task for determining general health. Existing efforts are manual, require considerable effort, and are prone to underestimation and misrepresentation...Full Text Available

2010-01-01

22

Substance use and dietary practices among students attending alternative high schools: results from a pilot study  

UK PubMed Central (United Kingdom)

BackgroundSubstance use and poor dietary practices are prevalent among adolescents. The purpose of this study was to examine frequency of substance use and associations between cigarette,...Full Text Available

23

Pregravid BMI is associated with dietary restraint and psychosocial factors during pregnancy1  

UK PubMed Central (United Kingdom)

The objective was to investigate the association of pregravid weight status, dietary restraint and psychosocial factors during pregnancy. We used data from the Pregnancy, Infection and Nutrition...Full Text Available

2009-03-01

24

PKC expression is regulated by dietary K intake and mediates internalization of SK channels in the CCD  

UK PubMed Central (United Kingdom)

We have used Western blot analysis and immunocytochemistry to determine the effect of dietary K intake on the expression of protein kinase C (PKC) isoforms in the kidney. Western blot has demonstrated...Full Text Available

2004-06-01

25

Expertise about herbs and dietary supplements among diverse health professionals  

UK PubMed Central (United Kingdom)

BackgroundHerbs and other dietary supplements are among the most commonly used complementary medical therapies. However, clinicians generally have limited knowledge, confidence and...Full Text Available

26

Effects of removal of dietary polyunsaturated fatty acids on plasma extravasation and mechanical allodynia in a trigeminal neuropathic pain model  

UK PubMed Central (United Kingdom)

BackgroundNeuropathic pain (NP) is partially mediated by neuroinflammatory mechanisms, and also modulates local neurogenic inflammation. Dietary lipids, in particular the total amount...Full Text Available

27

Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease  

UK PubMed Central (United Kingdom)

The effects of dietary monosodium glutamate (MSG) on trans-fatty acid (TFA)-induced nonalcoholic fatty liver disease (NAFLD) are addressed in an animal model. We used Affymetrix microarray...Full Text Available

2009-08-01

28

Dietary factors related to body weight in adult Vietnamese in the rural area of Haiphong, Vietnam: the Korean Genome and Epidemiology Study (KoGES)  

UK PubMed Central (United Kingdom)

The objectives of this study were to examine the association between dietary factors and underweight and overweight adult Vietnamese living in the rural areas of Vietnam. A cross-sectional study of...Full Text Available

2010-06-01

29

Demographic, Dietary, and Urinary Factors and 24-h Urinary Calcium Excretion  

UK PubMed Central (United Kingdom)

Background and objectives: Higher urinary calcium is a risk factor for nephrolithiasis. This study delineated associations between demographic, dietary, and urinary factors and 24-h urinary calcium.Design,...Full Text Available

2009-12-01

30

Assessing the effectiveness and cost effectiveness of adaptive e-Learning to improve dietary behaviour: protocol for a systematic review  

UK PubMed Central (United Kingdom)

BackgroundThe composition of habitual diets is associated with adverse or protective effects on aspects of health. Consequently, UK public health policy strongly advocates dietary...Full Text Available

31

A field study on the effects of dietary monensin on milk production and milk composition in dairy cows  

UK PubMed Central (United Kingdom)

The objectives of this study were to quantify the effect of 16 ppm of dietary monensin on milk production and composition of dairy cows, and to investigate factors having a potential impact on this...Full Text Available

2010-04-01

36

Effect of dietary constituents on the absorption of lead in the human  

International Nuclear Information System (INIS)

... biological effects body burden diet intestinal absorption lead lead 203 man

1983-03-01

40

Effect of dietary constituents on the gastrointestinal absorption of /sup 203/Pb in man  

Energy Technology Data Exchange (ETDEWEB)

The gastrointestinal absorption of lead was markedly increased in human subjects who had fasted before ingesting lead. Food in the gut was found to reduce lead absorption, and the effect of dietary constituents on /sup 203/Pb absorption was investigated. The greatest reduction in absorption was caused by minerals. This dependence of lead absorption on dietary constituents complicates the establishment of safe levels of lead in food and water.

1983-02-01

41

Characteristics of the Receptor for the Biosphere Model  

Energy Technology Data Exchange (ETDEWEB)

This analysis report is one of a series of technical reports that document the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the total system performance assessment (TSPA) for the geologic repository at Yucca Mountain. This report is one of the five biosphere reports that develop input parameter values for the biosphere model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes the conceptual model, as well as the mathematical model and its input parameters. Figure 1-1 is a graphical representation of the documentation hierarchy for the ERMYN. This figure shows relationships among the products (i.e., scientific analyses and model reports) developed for biosphere modeling and biosphere abstraction products for TSPA, as identified in the ''Technical Work Plan: for Biosphere Modeling and Expert Support'' (BSC 2004 [DIRS 169573]). The ...

2004-09-09

42

Hypothalamic and dietary control of temperature-mediated longevity  

UK PubMed Central (United Kingdom)

Temperature is an important modulator of longevity and aging in both poikilotherms and homeotherm animals. In homeotherms, temperature homeostasis is regulated primarily in the preoptic area...Full Text Available

2010-01-01

43

Hormone-Sensitive Lipase Knockouts  

UK PubMed Central (United Kingdom)

All treatments for obesity, including dietary restriction of carbohydrates, have a goal of reducing the storage of fat in adipocytes. The chief enzyme responsible for the mobilization of FFA from adipose...Full Text Available

46

Effects of dietary fibre on subjective appetite, energy intake and body weight: a systematic review of randomized controlled trials  

British Library Electronic Table of Contents (United Kingdom)

Summary Dietary fibres are believed to reduce subjective appetite, energy intake and body weight. However, different types of dietary fibre may affect these outcomes differently. The aim of this review was to systematically investigate the available literature on the relationship between dietary fibre types, appetite, acute and long-term energy intake, and body weight. Fibres were grouped according to chemical structure and physicochemical properties (viscosity, solubility and fermentability). Effect rates were calculated as the proportion of all fibre-control comparisons that reduced appetite (n-=-58 comparisons), acute energy intake (n-=-26), long-term energy intake (n-=-38) or body weight (n-=-66). For appetite, acute energy intake, long-term energy intake and body weight, there were cl...

2011-01-01

48

Dietary plant materials reduce acrylamide formation in cookie and starch-based model systems  

British Library Electronic Table of Contents (United Kingdom)

Abstract BACKGROUND: Dietary plant materials have attracted much attention because of their health benefits to humans. Acrylamide is found in various heated carbohydrate-rich foods. Our previous results showed that crude aqueous extracts from diverse dietary plants and some phenolic compounds could mitigate acrylamide formation in an asparagine-glucose model system. Based on our previous study, several plant materials were selected to further investigate their inhibitory effects on acrylamide formation in cookies and starch-based model systems. RESULTS: Addition of raw powders from selected dietary plants and their crude aqueous extracts could considerably reduce acrylamide formation in both cookie and potato starch-based models. Aqueous extracts of clove at 4% caused the largest reduction...

2011-01-01

49

Antioxidents and the costs of egg production: Studies in the Green Turtle (Chelonoa mydas)  

Environmental Research Database

DescriptionThis Studentship will focus on the implications of material nutrition and health for reproduction in green turtles, and specifically the role played by dietary carotenoids.

2009-01-30

50

APOPTOSIS BY DIETARY AGENTS FOR PREVENTION AND TREATMENT OF CANCER  

UK PubMed Central (United Kingdom)

The role of apoptosis or programmed cell death in the regulation of development and maintenance of homeostasis in multicellular organisms is well established. During the last decade, naturally...Full Text Available

2008-12-01

51

The potential of non-toxic tannins to improve the utilisation of nitrogen compounds in grass silage by ruminants  

Environmental Research Database

DescriptionInefficient utilisation of dietary nitrogen (N) by animals results in the excretion of N in varying forms, with adverse environmental consequences. Grass silage is a major component of the diet of ruminant livestock in the UK, but the protein in silage is very highly degraded as a result of the ensilage process. This results in poor capture of the silage N by rumen microbes leading to overall poor utilisation for the synthesis of milk or meat. As a result, significant quantities of dietary N are [continued...

2006-01-31

52

The Small Rice Bowl-Based Meal Plan was Effective at Reducing Dietary Energy Intake, Body Weight, and Blood Glucose Levels in Korean Women with Type 2 Diabetes Mellitus  

UK PubMed Central (United Kingdom)

BackgroundThe typical Korean diet includes rice, which is usually served in a rice bowl. We investigated the effects of a meal plan using rice bowls of varying sizes on dietary energy...Full Text Available

2010-12-01

53

Iodine nutrition and risk of thyroid irradiation from nuclear accidents  

International Nuclear Information System (INIS)

The objectives of this paper are to discuss the following aspects of physiopathology of iodine nutrition related to thyroid irradiation by nuclear accidents: (1) The cycle of iodine in nature, the dietary sources of iodine and the recommended dietary allowances for iodine. (2) The anomalies of thyroid metabolism induced by iodine deficiency. The caricatural situation as seen in endemic goitre will be used as mode. (3) The specific paediatric aspects of adaptation to iodine deficiency. (4) The present status of iodine nutrition in Europe. (author).

54

Effect of dietary and synthetic chelating agents on the intestinal absorption of lead. [Rats  

Energy Technology Data Exchange (ETDEWEB)

The effect of a number of dietary and synthetic chelating agents on the intestinal absorption of lead has been examined using the everted sac preparation and the tracer isotope /sup 203/Pb. All the agents examined increased lead transport into the serosal compartment. An explanation of the way in which these agents modify the model to describe lead transport is proposed.

1982-01-01

55

Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study123  

UK PubMed Central (United Kingdom)

Background: Diet plays a key role in the development of type 2 diabetes (T2D), but little is known about the contributions of specific nutrients in populations in which dietary patterns...Full Text Available

2009-04-01

56

Effect of replacing dietary fish oil with soybean oil on production performance and fillet lipid and fatty acid composition of juvenile cobia Rachycentron canadum  

British Library Electronic Table of Contents (United Kingdom)

Abstract As a marine carnivore exhibiting exceptionally high growth rates, cobia are considered a species for which fish oil (FO) replacement may be difficult. However, partial, if not complete, FO replacement is necessary to ensure sustainability. We evaluated the effects of graded substitution of dietary FO with soybean oil (SO) in cobia culture. Feeds contained FO (100% FO), SO (0% FO) or blends of the two (67% FO, 33% FO) as the supplemental lipid source. Production performance was largely unaffected by partial replacement of FO with SO: feed intake and final weight were reduced only in the 0% FO dietary treatment. Fillet total lipid fatty acid (FA) composition differed among the dietary treatments, closely approximating dietary FA profile. As increasing amounts of FO were replaced, SO...

2011-01-01

57

Characteristics of the Receptor for the Biosphere Model  

Energy Technology Data Exchange (ETDEWEB)

This analysis report is one of a series of technical reports that document the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the total system performance assessment (TSPA) for the geologic repository at Yucca Mountain. This report is one of the five biosphere reports that develop input parameter values for the biosphere model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes the conceptual model, as well as the mathematical model and its input parameters. Figure 1-1 is a graphical representation of the documentation hierarchy for the ERMYN. This figure shows relationships among the products (i.e., scientific analyses and model reports) developed for biosphere modeling and biosphere abstraction products for TSPA, as identified in the ''Technical Work Plan for Biosphere Modeling and Expert Support'' (BSC 2005 [DIRS 172782]). The ...

2005-04-05

58

Protective effects of long term dietary restriction on swimming exercise-induced oxidative stress in the liver, heart and kidney of rat  

British Library Electronic Table of Contents (United Kingdom)

In this study, we evaluated the hypothesis that long term dietary restriction would have beneficial effects on the oxidative stress and antioxidant enzyme systems in liver, heart and kidney in adult male rats undergoing different intensities of swimming exercise. Sixty male, Sprague-Dawley rats were assigned as either dietary restricted on every other week day (DR) or fed ad libitum (AL) groups, and each group was further subdivided into sedentary, endurance swimming exercise training (submaximal exercise) and exhaustive swimming exercise (maximal exercise) groups. Animals in the submaximal exercise group swam 5 days/week for 8 weeks, while maximal exercise was performed as an acute bout of exercise. In parallel with the increase in the intensity of the exercise, the degree of lipid peroxi...

2007-01-01

59

Effects of dietary glucosylceramide on dermatitis in atopic dermatitis model mice  

British Library Electronic Table of Contents (United Kingdom)

The effects of dietary plant and yeast cerebroside (glucosylceramide), a major sphingolipid in plants and yeast, on atopic dermatitis (AD) like symptoms were investigated in a mouse model. After 7 wk of feeding with a diet containing maize glucosylceramide, plasma IgE levels became significantly lower and in contrast, the levels of interleukin (IL)-12, which induces cellular immunity, became significantly higher in the AD mice than in the controls. However, the sphingolipid constituents of the skin fraction in the maize glucosylceramide fed group did not contain sphingoid bases of plant origin, such as 8-unsaturated sphingoid bases. The results of the present study indicated that dietary plant glucosylceramide prevented AD-like symptoms in AD model mice via regulation of Th1/Th2 balance. P...

2010-01-01

60

Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder - a preliminary study  

British Library Electronic Table of Contents (United Kingdom)

Please cite this paper as: Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder - a preliminary study. Experimental Dermatology 2008; 17: 203-207. Abstract: Pseudoxanthoma elasticum (PXE), a heritable multisystem disorder, is caused by mutations in the ABCC6 gene. We have developed a murine model for PXE by targeted inactivation of the corresponding mouse gene. A feature of this mouse model is ectopic mineralization of connective tissue capsule surrounding the bulb of vibrissae. This study was designed to investigate the effect of dietary sevelamer hydrochloride (Renagel), a phosphate binder, and specific mineral modifications on ectopic mineralization of connective tissue in Abcc6-/- mice. Three groups were fed a specific di...

2008-01-01

61

{sup 3}H-tetracycline as a proxy for {sup 41}Ca for measuring dietary perturbations of bone resorption  

Energy Technology Data Exchange (ETDEWEB)

Our group is interested in evaluating early effects of dietary interventions on bone loss. Postmenopausal women lose bone following reduction in estrogen which leads to increased risk of fracture. Traditional means of monitoring bone loss and effectiveness of treatments include changes in bone density, which takes 6 months to years to observe effects, and changes in biochemical markers of bone turnover, which are highly variable and lack specificity. Prelabeling bone with {sup 41}Ca and measuring urinary {sup 41}Ca excretion with accelerator mass spectrometry provides a sensitive, specific, and rapid approach to evaluating effectiveness of treatment. To better understand {sup 41}Ca technology as a tool for measuring effective treatments on reducing bone resorption, we perturbed bone resorption by manipulating dietary calcium in rats. We used {sup 3}H-tetracycline ({sup 3}H-TC) as a proxy for {sup 41}Ca and found that a single dose is feasible ...

2007-06-15

62

Usual Energy Intake from Saturated Fat  

Science.gov (United States)

Skip to Content Cancer Control and Population Sciences Home Applied Research Home Risk Factor Monitoring and Methods Home Diet Usual Dietary Intakes: Background The NCI Method Details of the NCI Method Food Intakes, US Population, 2001-04 Selected Intakes

63

Usual Energy Intake from Monounsaturated Fat  

Science.gov (United States)

Skip to Content Cancer Control and Population Sciences Home Applied Research Home Risk Factor Monitoring and Methods Home Diet Usual Dietary Intakes: Background The NCI Method Details of the NCI Method Food Intakes, US Population, 2001-04 Selected Intakes

64

Uneven dietary development: linking the policies and processes of globalization with the nutrition transition, obesity and diet-related chronic diseases  

UK PubMed Central (United Kingdom)

In a "nutrition transition", the consumption of foods high in fats and sweeteners is increasing throughout the developing world. The transition, implicated in the rapid rise of obesity and diet-related...Full Text Available

65

The Effects on Saturated Fat Purchases of Providing Internet Shoppers with Purchase- Specific Dietary Advice: A Randomised Trial  

UK PubMed Central (United Kingdom)

Objectives:The supermarket industry now services many customers through online food shopping over the Internet. The Internet shopping process offers a novel opportunity...Full Text Available

66

Sec24C is required for docking the prechylomicron transport vesicle with the Golgi  

UK PubMed Central (United Kingdom)

The rate-limiting step in the transit of dietary fat across the intestinal absorptive cell is its exit from the endoplasmic reticulum (ER) in a specialized ER-to-Golgi transport vesicle, the prechylomicron...Full Text Available

2010-05-01

67

Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice  

UK PubMed Central (United Kingdom)

Insulin resistance plays a central role in type 2 diabetes and obesity, which develop as a consequence of genetic and environmental factors. Dietary changes including high fat diet (HFD) feeding promotes...Full Text Available

68

Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation  

UK PubMed Central (United Kingdom)

There are many factors that can influence glucose uptake by contracting skeletal muscle during exercise and although one may be intramuscular glycogen content, this relationship is at present not fully...Full Text Available

2002-05-15

69

Long-term impact of four different strategies for delivering an on-line curriculum about herbs and other dietary supplements  

UK PubMed Central (United Kingdom)

BackgroundPrevious research has shown that internet education can lead to short-term improvements in clinicians' knowledge, confidence and communication practices. We wished to better...Full Text Available

70

Lack of association between dietary fructose and hyperuricemia risk in adults  

UK PubMed Central (United Kingdom)

BackgroundHigh serum uric acid concentration (hyperuricemia) has been studied for its relationship with multiple adverse health outcomes, such as metabolic syndrome. Intervention...Full Text Available

71

Hepatotoxicity of High Oral Dose (-)-Epigallocatechin-3-Gallate in Mice  

UK PubMed Central (United Kingdom)

The tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been studied for chronic disease preventive effects, and is marketed as part of many dietary supplements. However, case reports have...Full Text Available

2010-01-01

72

Genotype-specific responses in Atlantic salmon (Salmo salar) subject to dietary fish oil replacement by vegetable oil: a liver transcriptomic analysis  

UK PubMed Central (United Kingdom)

BackgroundExpansion of aquaculture is seriously limited by reductions in fish oil (FO) supply for aquafeeds. Terrestrial alternatives such as vegetable oils (VO) have been investigated...Full Text Available

73

Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes  

UK PubMed Central (United Kingdom)

Bitter orange (Citrus aurantium) extract is widely used in dietary supplements for weight management and sports performance. Its primary protoalkaloid is p-synephrine....Full Text Available

74

Effects of biotin supplementation on serum biotin levels and physical properties of samples of solar horn of Holstein cows  

UK PubMed Central (United Kingdom)

AbstractEffects of dietary biotin supplementation on serum biotin levels and physical properties of sole horn of 40 Holstein cows were evaluated. The mean serum biotin level in biotin-supplemented...Full Text Available

2004-04-01

75

Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice  

UK PubMed Central (United Kingdom)

Chemoprevention strategies to prevent the development of lung cancer in at-risk individuals are a key component in disease management. In addition to being highly effective, an ideal chemopreventive...Full Text Available

2008-08-01

76

Effect of a mixture of micronutrients, but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers: a randomized placebo-controlled study  

UK PubMed Central (United Kingdom)

BackgroundSupplementation of nutritional deficiencies helps to improve immune function and resistance to infections in malnourished subjects. However, the suggested benefits of dietary...Full Text Available

77

Effect of Anionic Salt and Highly Fermentable Carbohydrate Supplementations on Urine pH and on Experimentally Induced Hypocalcaemia in Cows  

UK PubMed Central (United Kingdom)

The objective of this experiment was to determine the effect of dietary grain on calcium homeostasis. Six rumen-fistulated dairy cows with 3 or more previous lactations and no history of parturient...Full Text Available

2004-01-01

78

Does hypothalamic SIRT1 regulate aging?  

UK PubMed Central (United Kingdom)

In virtually all organisms, life expectancy is profoundly affected by caloric intake. For example, dietary restriction (DR; a feeding regimen of fewer calories compared to the ad libitum level without...Full Text Available

79

Dietary patterns associated with fall-related fracture in elderly Japanese: a population based prospective study  

UK PubMed Central (United Kingdom)

BackgroundDiet is considered an important factor for bone health, but is composed of a wide variety of foods containing complex combinations of nutrients. Therefore we investigated...Full Text Available

80

Dietary Ammonium Chloride for the Acidification of Mouse Urine  

UK PubMed Central (United Kingdom)

A novel therapeutic compound was found to induce bladder tumors in male rats. Given the location of the tumors and the increased amounts of calcium- and magnesium-containing solids found in the urine...Full Text Available

2009-03-01

81

Decreased respiratory quotient in relation to resting energy expenditure in HIV-infected and non-infected subjects  

UK PubMed Central (United Kingdom)

The purpose of this study was to evaluate the relationship of respiratory quotient (RQ), a surrogate marker of substrate oxidation, as well as body composition and dietary intake to resting...Full Text Available

2009-05-01

82

Creatine and Phosphocreatine: A Review of Their Use in Exercise and Sport  

UK PubMed Central (United Kingdom)

Objective: Creatine and phosphocreatine (PCr) are important compounds in the normal energy metabolism of muscle. Recently, it has been shown that dietary creatine (5 to 20 g/day)...Full Text Available

1997-01-01

83

Chylopericardium after cardiac surgery can be treated successfully by oral dietary manipulation: a case report  

UK PubMed Central (United Kingdom)

We report a case of chylopericardium after ascending aorta and aortic valve replacement, which presented as late tamponade. We discuss the various treatment options in this rare condition which can...Full Text Available

84

Characterization of the stimulatory effect of high-fat diets on peroxisomal beta-oxidation in rat liver.  

UK PubMed Central (United Kingdom)

1. The effect on rat liver peroxisomal beta-oxidation of feeding diets containing various amounts of dietary oils was investigated. With increasing amounts (5-25%, w/w) of soya-bean oil an apparent,...Full Text Available

1982-08-15

85

Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective  

UK PubMed Central (United Kingdom)

Malnutrition is common among older persons, with important consequences increasing frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR, a low-calorie dietary...Full Text Available

86

Association between hair mineral and age, BMI and nutrient intakes among Korean female adults  

UK PubMed Central (United Kingdom)

This study was performed to investigate the association between hair mineral levels and nutrient intakes, age, and BMI in female adults who visited a woman's clinic located in Seoul. Dietary intakes...Full Text Available

2009-01-01

87

A study on multi-cultural family wives adapting to Korean cuisine and dietary patterns  

UK PubMed Central (United Kingdom)

With the increase in multi-cultural families, Korea is seeing a rapid increase in immigrated housewives, who are closely related to food culture. However, studies for the diet of multi-cultural families,...Full Text Available

2010-10-01

88

Influence of dietary amino acids on lead absorption  

International Nuclear Information System (INIS)

Dietary supplements of about 5 g/kg of a number of amino acids increased tissue lead concentrations in newly weaned rats but decreased them in older rats. The retention of both oral and intraperitoneal lead was affected. The uptake of "2"0"3Pb by tissues was reduced when methionine was given in the diet over a period of 5 weeks or when it or ethionine was given by mouth 24 h before the activity was measured. In the liver the fraction of the total activity found in the nuclei and mitochondria was increased by methionine, but in the kidney only the fraction found in nuclei was increased.

89

Human dietary intakes of trace elements: A global literature survey mainly for the period 1970-1991: 1. Data listings and sources of information  

International Nuclear Information System (INIS)

A database has been compiled on human dietary intakes of trace elements by populations groups living in various countries. The main sources of information used were (1) publications in the open scientific literature, and (2) data submitted to the IAEA in response to a questionnaire. The database contains 1,758 intake values covering 35 elements and 47 countries. In this report the data are listed in various ways to facilitate identification of intake values for any specified country, element and population group. 4 refs, 5 tabs.

90

The effect of high ascorbic acid supplementation on body iron stores  

Energy Technology Data Exchange (ETDEWEB)

The level of assimilation of dietary iron is believed to have an important influence on iron status. To examine the effect of enhancing the availability of dietary iron on iron balance, 17 adult volunteer subjects were given 2 g of ascorbic acid daily with meals for 16 weeks. Serum ferritin levels before and after the study averaged 46 and 43 micrograms/L, respectively, indicating a negligible effect on iron stores. When vitamin C supplementation was continued for an additional 20 months in five iron-replete and four iron-deficient subjects, serum ferritin determinations again failed to indicate any significant effect of the vitamin C on iron reserves. These findings were not explained by intestinal adaptation to the enhancing effect of the vitamin, because radioisotopic measurements of nonheme iron absorption showed no reduction in the enhancing effect of 1 g of ascorbic acid after four months of megadoses of vitamin C. It is concluded that ...

1984-09-01

91

Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii, and California: demographic, physical, dietary, and biochemical characteristics  

International Nuclear Information System (INIS)

These summary descriptive data of ethnically similar cohorts of indigenous and migrant Japanese males have shown similarities or slight differences in characteristics wholly or largely genetically determined, such as blood groups, stature, and skeletal size. Differences have been noted in characteristics largely environmental or behavioral, such as diet and cigarette smoking habit, as well as in characteristics determined by a varying mixture of genetic and environmental influences, such as weight, blood pressure, glucose tolerance, and serum lipid and uric acid levels. Detailed analyses of the distributions of laboratory variables, of dietary data obtained by different methods, and of correlations among laboratory, dietary, physical, and demographic variables are currently in progress. Also part of the study plan are determinations of disease prevalence from evaluation of examination, laboratory, and electrocardiographic findings, of disease ...

92

Effects of dietary chitosan and Bacillus subtilis on the growth performance, non-specific immunity and disease resistance of cobia, Rachycentron canadum  

British Library Electronic Table of Contents (United Kingdom)

The present study was performed to investigate the effects of various levels of dietary Bacillus subtilis and chitosan on the growth performance, non-specific immunity and protection against Vibrio harveyi infection in cobia, Rachycentron canadum. Fish were fed with the control diet and six different experimental diets containing three graded levels of B. subtilis at 2 x 10^1^0 CFU g^-^1 (0.0, 1.0, 2.0 g kg^-^1 diet) for each of two levels of chitosan (3.0 and 6.0 g kg^-^1 diet). The results of 8 weeks feeding trial showed that the survival rate ranged from 81.3% to 84.0% with no significant difference (P > 0.05). The SGR (%) in the fish fed with dietary treatments was significantly higher than that of the control fish except diet 6 group with 2.0 g kg^-^1B. subtilis and 3.0 g kg^-^1 chito...

2011-01-01

93

Strategies to Promote High School Students’ Healthful Food Choices  

British Library Electronic Table of Contents (United Kingdom)

Studies have suggested that skill-building through hands-on cooking as a nutrition education strategy, is effective to improve overall dietary quality among participants. FamilyCook Productions' ''Diet for a Healthy Planet with Teen Battle Chefs(TM)'' curriculum using this approach, was piloted in 2008 in a Brooklyn public high school resulting in a statistically significant improvements in dietary quality as well as attitudinal improvements and efforts by students to support changes in school food service. Program evaluation used the RE-AIM framework and employed both quantitative and qualitative strategies including pre and post program surveys, focus groups, and weekly electronic teacher feedback. The program has since grown to over 85 high schools in 16 states.

2011-01-01

94

Nutrition and Physical Activity in Aging, Obesity, and Cancer  

British Library Electronic Table of Contents (United Kingdom)

A wide variety of phytochemicals present in our diet, including fruits, vegetables, and spices, have been shown to possess a broad range of health-beneficial properties. The cytoprotective and restorative effects of dietary phytochemicals are likely to result from the modulation of several distinct cellular signal transduction pathways. Many dietary phytochemicals that are synthesized as secondary metabolites function as toxins, that is, -phytoalexins,- and hence protect plants against insects and other damaging organisms and stresses. However, at the relatively low doses consumed by humans and other mammals, these same toxic plant-derived chemicals, as mild stressors, activate adaptive cellular response signaling, conferring stress resistance and other health benefits. This phenomenon has...

2011-01-01

95

Enzymatic solubilization of a pectinaceous dietary fiber fraction from potato pulp: Optimization of the fiber extraction process  

British Library Electronic Table of Contents (United Kingdom)

Upgrading of potato pulp, a byproduct stream from industrial manufacture of potato starch, is important for the continued economic competitiveness of the potato starch industry. The major part of potato pulp consists of the tuber plant cell wall material which is particularly rich in galactan branched rhamnogalacturonan I type pectin. In the work reported here, the release of high-molecular weight pectinaceous dietary fiber polysaccharides from starch free potato pulp was accomplished by use of a multicomponent pectinase preparation from Aspergillus aculeatus (Viscozyme L). The enzyme reaction conditions for the solubilization were optimized via a surface response design to be addition of 0.27% Viscozyme L by weight of potato pulp substrate dry matter, 1h treatment at pH 3.5, 62.5degreeC. ...

2009-01-01

96

Effects of Dietary Glycyrrhizin on Growth and Nonspecific Immunity of White Shrimp, Litopenaeus vannamei  

British Library Electronic Table of Contents (United Kingdom)

The growth response, total hemocyte count (THC), respiratory burst (release of superoxide anion), phenoloxidase (PO) activity, superoxide dismutase (SOD) activity, nitric oxide synthase (NOS) activity as well as resistance to the pathogen Vibrio alginolyticus were measured in Litopenaeus vannamei, which had been fed diets supplemented with glycyrrhizin (the aqueous extract of licorice, Glycyrrhiza glabra, roots) at 0, 50, 100, 150, and 200 mg/kg of feed for 8 wk. In the feeding trial, there was no significant difference in survival rate (P > 0.05). Significant higher specific growth rate was observed in treatments with dietary glycyrrhizin than that in the control group (P < 0.05). Shrimp fed a diet with 200 mg/kg of glycyrrhizin had significant higher THC, PO activity, respiratory burst a...

2010-01-01

97

Effect of Nordic diets on ECOSYS model predictions of ingestion doses  

British Library Electronic Table of Contents (United Kingdom)

The ECOSYS model is used to estimate ingestion dose in the ARGOS and RODOS decision support systems for nuclear emergency management. It is recommended that nation-specific values for several parameters are used in the model. However, this is generally overlooked when the systems are used in practice. We have estimated first year ingestion doses in two scenarios with wet and dry deposition of 137Cs, using the ECOSYS model. We calculated doses for each country using national dietary data while keeping all other parameters at their default values. These dose calculations were then used to estimate the variation in ingestion doses resulting from the variation in the diets only. The dietary data demonstrated that the average consumption of milk, meat and vegetables varied by a factor of 2-4 am...

2010-01-01

98

Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-?B pathway to alter cellular responses during hamster buccal pouch carcinogenesis  

British Library Electronic Table of Contents (United Kingdom)

The chemopreventive efficacy of turmeric has been established in experimental systems. However, its mechanism(s) of action are not fully elucidated in vivo. The present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis at 2, 4, 6, 10 and 12?weeks. Dietary turmeric (1%) led to decrease in DMBA-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modulatory effects on oncogene products and various cellular responses during HBP tumorigenesis. DMBA-induced expression of ras oncogene product, p21 and downstream target, the mitogen-activated protein kinases were significantly decreased by turmeric during HBP carcinogenesis. Turmeric also diminished ...

2008-01-01

99

Dietary and Nutritional Treatments for Attention-Deficit/Hyperactivity Disorder: Current Research Support and Recommendations for Practitioners  

British Library Electronic Table of Contents (United Kingdom)

Evidence for dietary/nutritional treatments of attention-deficit/hyperactivity disorder (ADHD) varies widely, from double-blind, placebo-controlled trials to anecdotal. In guiding patients, clinicians can apply the SECS versus RUDE rule: treatments that are Safe, Easy, Cheap, and Sensible (SECS) require less evidence than those that are Risky, Unrealistic, Difficult, or Expensive (RUDE). Two nutritional treatments appear worth general consideration: Recommended Daily Allowance/Reference Daily Intake multivitamin/mineral supplements as a pediatric health intervention not specific to ADHD and essential fatty acids, especially a mix of eicosapentaenoic acid, docosahexaenoic acid, and ?-linolenic acid as an ADHD-specific intervention. Controlled studies support the elimination of artificial fo...

2011-01-01

100

Nuclear methods monitor nutrition  

International Nuclear Information System (INIS)

Neutron activation of nitrogen and hydrogen in the body, the isotope dilution technique and the measurement of naturally radioactive potassium in the body are among the new nuclear methods, now under collaborative development by the Australian Nuclear Scientific and Technology Organization and medical specialists from several Sydney hospitals. These methods allow medical specialists to monitor the patient's response to various diets and dietary treatments in cases of cystic fibrosis, anorexia nervosa, long-term surgical trauma, renal diseases and AIDS. ills.

101

Exploiting the beneficial effects of PPO on the utilisation of protein and lipids in grazed forages  

Environmental Research Database

DescriptionThe plant enzyme polyphenol oxidase (PPO) has been demonstrated to reduce both proteolysis and lipolysis during the ensiling of red clover. The purpose of this work is to explore the potential for exploiting this beneficial trait in other dietary regimes for grazing ruminants. These studies will focus on the development of new strategies for forage management and livestock feeding by increasing the efficiency of feed protein-N utilisation and reducing saturated fatty acid production by ruminan [continued...

2007-01-31

102

Evaluate the Health Potential of Fruit & Vegetable Snack Products (EFH 11)  

Environmental Research Database

DescriptionDespite the growing recognition of the important part fruit and vegetables can play in helping prevent a number of diseases, health and nutrition experts are concerned about the low consumption of fruits and vegetables in the UK. The principal aim of this project is to improve consumer dietary consumption of fruit and vegetables by developing novel snack foods based on the fruit and vegetable materials using extrusion processing.

2005-01-31

103

Effects of xylitol on the absorption of /sup 203/Pb in mice and cockerels  

Energy Technology Data Exchange (ETDEWEB)

Earlier studies have indicated that xylitol may increase the absorption and urinary excretion of dietary oxalate. It has also been indicated that xylitol increases the absorption of calcium. Intestinal absorption of lead, a divalent contaminant in the diet, is in many respects similar to that of calcium. The purpose of this study was to evaluate the effects of xylitol on the intestinal absorption of lead using two different approaches: the in situ ligated intestinal loop technique in cockerels and gastric gavage in mice.

1986-07-01

104

Effects of an elemental diet, inert bulk and different types of dietary fibre on the response of the intestinal epithelium to refeeding in the rat and relationship to plasma gastrin, enteroglucagon, and PYY concentrations.  

UK PubMed Central (United Kingdom)

Refeeding starved rats with an elemental diet resulted in a marked increase in crypt cell production rate (CCPR) in the proximal small intestine but not in the distal regions of the gut. Little effect...Full Text Available

1987-02-01

105

Effect of dietary fatty acid intake on prospective weight change in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition  

DEFF Research Database (Denmark)

OBJECTIVE: To evaluate the association between fatty acid (alpha-linolenic acid (ALA), EPA, DHA, palmitic, stearic, oleic, linoleic and arachidonic acids) intake and prospective weight change in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. DESIGN: Prospective cohort study with mean follow-up time of 6.5 years. In a total of 9182 men and 10867 women aged 35 to 64 years, from body weight measurement at recruitment and calibrated body weight during follow-up, weight change was expressed as mean annual weight change relative to baseline weight (%/year) and categorised into four groups (weight loss, or =2.5 to or =7.5%/5 years). Energy-adjusted dietary fatty acid intake data were estimated from the FFQ completed at baseline. Multivariate linear regression models as well as multinomial logistic regression analyses (carbohydrate replacement models) were conducted. RESULTS: Stearic acid intake was linearly associated with ...

2010-01-01

106

Effect of Rapid Human N-acetyltransferase 2 Haplotype on DNA Damage and Mutagenesis Induced by 2-Amino-3-methylimidazo [4,5-f] quinoline (IQ) and 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx)  

UK PubMed Central (United Kingdom)

Heterocyclic amines such as 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) and 2-amino-3,8-dimethylimidazo [4,5-f] quinoxaline (MeIQx) are dietary carcinogens generated when meats are cooked...Full Text Available

2010-02-03

107

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice  

UK PubMed Central (United Kingdom)

Little is known about how diet and energy metabolism interact in determination of lifespan under ad libitum feeding. From 12 weeks of age until death, male and female wild-type (WT) and transgenic (TG)...Full Text Available

2011-02-01

108

Daily | Best sexual wellness info - Part 2  

Wastenet

...Box Contains One Month Supply Dietary supplement with a premium patented formula of L-Arginine, Ginseng, Ginkgo plus 13 essential vitamins, antioxidants, and minerals to support male sexual function . ArginMax for Male Sexual Fitness is a patented combination of l-Arginine, Ginseng, Ginkgo, and 13 essential vitamins and ...

109

Catalyst: Dietary Supplements - ABC TV Science  

Wastenet

... However blaming vitamin supplements on deaths, or mortality is silly, as the studies are not exactly kosher. Vitamin C in 2,000mg is good for allergies, and niacin (b3) in 10,0000mg is good for depression. This is all examples on how vitamin supplements can help. I call it a security blanket, as food these days is not so good due vitamin and mineral damage due to light, or storage. By the time we eat the apple from the supermarket, there is minimal vitamin and ...

112

Macronutrient self-selection in Solea senegalensis fed macronutrient diets and challenged with dietary protein dilutions  

British Library Electronic Table of Contents (United Kingdom)

Macronutrient self-selection and responses to dietary protein dilution were investigated in Senegalese sole, a flatfish species of interest for Mediterranean aquaculture. Eight groups of six sole were distributed among 75-l tanks and allowed to feed on three experimental diets composed of pure macronutrients: PC (75% crude protein and 25% carbohydrate), PF (75% crude protein and 25% crude fat) and PFC (10% crude protein, 45% crude fat and 45% carbohydrate). Choosing from the above diets, the sole selected a diet containing 68.0% crude protein, 15.7% crude fat and 16.3% carbohydrate. When the PF diet was diluted 50% with cellulose, the fish increased their feed intake to sustain the energy intake (5.0?kJ/kg BW/day). Their selection of fat remained unchanged, while carbohydrate selection sig...

2009-01-01

113

Influence of animal age upon antioxidant-modified UV carcinogenesis  

International Nuclear Information System (INIS)

Studies were undertaken to examine the effects of animal age on the anticarcinogenic properties of antioxidants. Female hairless mice, 2.5, 4.5 and 9.5 months of age, were subjected to daily irradiation from Westinghouse BZS-WLG lamps for 19 weeks. Experimental groups of animals were maintained on a commercial rodent meal supplemented with a 2% (w/w) antioxidant mixture. Control groups received only the meal. Tumour latency, expressed as median time to tumor development, was significantly greater for all age groups receiving antioxidants than for their similarly aged controls. However, the response to antioxidants appeared to decrease with age and the antioxidant effect was significantly less in the 9.5 month-old group than in the 2.5 month-old group. Likewise, the two youngest groups receiving antioxidants demonstrated a significantly fewer number of tumors per animal. It is concluded that animal age influences the degree of photoprotection provided by antioxidants. Whether this ...

114

Epigenomic disruption: the effects of early developmental exposures.  

Science.gov (United States)

Through DNA methylation, histone modifications, and small regulatory RNAs the epigenome systematically controls gene expression during development, both in utero and throughout life. The epigenome is also a very reactive system; its labile nature allows it to sense and respond to environmental perturbations to ensure survival during fetal growth. This pliability can lead to aberrant epigenetic modifications that persist into later life and induce numerous disease states. Endocrine-disrupting compounds (EDCs) are ubiquitous chemicals that interfere with growth and development. Several EDCs also interfere with epigenetic programming. The investigation of the epigenotoxic effects of bisphenol A (BPA), an EDC used in the production of plastics and resins, has further raised concern over the impact of EDCs on the epigenome. Using the Agouti viable yellow (A(vy)) mouse model, dietary BPA exposure was shown to hypomethylate both the A(vy) and the Cabp(IAP) metastable ...

2010-10-01

115

Hypothalamic control of energy and glucose metabolism  

British Library Electronic Table of Contents (United Kingdom)

The central nervous system (CNS), generally accepted to regulate energy homeostasis, has been implicated in the metabolic perturbations that either cause or are associated with obesity. Normally, the CNS receives hormonal, metabolic, and neuronal input to assure adequate energy levels and maintain stable energy homeostasis. Recent evidence also supports that the CNS uses these same inputs to regulate glucose homeostasis and this aspect of CNS regulation also becomes impaired in the face of dietary-induced obesity. This review focuses on the literature surrounding hypothalamic regulation of energy and glucose homeostasis and discusses how dysregulation of this system may contribute to obesity and T2DM.

2011-01-01

116

Effect of calcium and phosphorus on the gastrointestinal absorption of /sup 203/Pb in man  

Energy Technology Data Exchange (ETDEWEB)

Calcium and phosphorus were mainly responsible for reducing the gastrointestinal absorption of lead in human subjects. The effect of calcium was greater than phosphorus, and their combined effect was more than additive. Increasing weights of calcium and phosphorus progressively reduced lead absorption. The relationship between absorption and increasing weights could be described by two negative exponentials. These effects could be explained if lead competed with calcium and phosphorus for common transport mechanisms in the gut. Milk was also found to reduce lead absorption. Adding milk to the diet of people with low dietary calcium intake could reduce the possibility of increased absorption of ingested lead.

1983-02-01

117

Gastrointestinal absorption of lead in chicks: involvement of the cholecalciferol endocrine system  

Energy Technology Data Exchange (ETDEWEB)

The role of dietary calcium and phosphorus in modifying the intestinal absorption of lead and also the effect of lead ingestion on the metabolism of cholecalciferol were studied in chicks. The efficiency of absorption of /sup 203/Pb and /sup 47/Ca was increased when the animals were fed a low calcium diet and treated with cholecalciferol. The synthesis of the vitamin D-induced calcium-binding protein (CaBP) was correspondingly increased. When the chicks were depleted of vitamin D and repleted with 1,25-dihydroxycholecalciferol (1,25(OH)/sub 2/D/sub 3/) as their only source of the vitamin, the absorption of both /sup 47/Ca and /sup 203/Pb was unaffected by dietary calcium levels, and no change in CaBP levels occurred. Low dietary intake of phosphorus resulted in an increase in /sup 47/Ca and /sup 203/Pb absorption and in CaBP synthesis when the animals were treated with cholecalciferol. However, when the birds were repleted ...

1984-04-01

118

Gastrointestinal absorption of lead in chicks: involvement of the cholecalciferol endocrine system  

International Nuclear Information System (INIS)

The role of dietary calcium and phosphorus in modifying the intestinal absorption of lead and also the effect of lead ingestion on the metabolism of cholecalciferol were studied in chicks. The efficiency of absorption of "2"0"3Pb and "4"7Ca was increased when the animals were fed a low calcium diet and treated with cholecalciferol. The synthesis of the vitamin D-induced calcium-binding protein (CaBP) was correspondingly increased. When the chicks were depleted of vitamin D and repleted with 1,25-dihydroxycholecalciferol [1,25(OH)_2D_3] as their only source of the vitamin, the absorption of both "4"7Ca and "2"0"3Pb was unaffected by dietary calcium levels, and no change in CaBP levels occurred. Low dietary intake of phosphorus resulted in an increase in "4"7Ca and "2"0"3Pb absorption and in CaBP synthesis when the animals were treated with cholecalciferol. However, when the birds were repleted with 1,25(OH)_2D_3, the ...

119

A High Throughput Combinatorial Library Technique for Identifying Formalin-Sensitive Epitopes  

UK PubMed Central (United Kingdom)

We present a technique for identifying the amino acids responsible for a loss of immunoreactivity in response to treating an antigen with a chemical modifier. This is of particular interest...Full Text Available

2006-12-20

120

Osteoporosis and prevention. Assessment of mineral density, geometry and biomechanics of bone by means of peripheral quantitative Computed Tomography (pQCT) in premenopausal women assuming phytoestrogens; Osteoporosi e fitoestrogeni: valutazione della densita' minerale ossea mediante tomografia computerizzata quantitativa periferica nelle donne lattoovovegetariane nella premenopausa  

Energy Technology Data Exchange (ETDEWEB)

Aim of the work was to describe the noninvasive assessment of bone mineral density, geometrical and biochemical properties in premenopausal women with dietary intake of phytoestrogens and comparison of these parameters with those of age-matched female subjects with Mediterranean dietary intake lacking in these substances. Volumetric cortical, trabecular and total mineral density and bone geometrical properties were evaluated with peripheral quantitative computed tomography (pQCT) at the distal radius of the non dominant forearm. pQCT showed higher bone mineral density (total and trabecular) and SSI values in premenopausal with dietary intake of phytoestrogens. Despite the lack of statistical significance, these preliminary results, should further support the few literature findings about the potential role of phytoestrogens consumption in preventing trabecular bone loss. However, further studies are warranted to evaluate ...

2000-04-01

121

Use of electron beam irradiation to improve the microbiological safety of Hippophae rhamnoides  

Energy Technology Data Exchange (ETDEWEB)

Sea buckthorn (Hippophae rhamnoides) is increasingly used in food supplements due to its dietary and medicinal compounds with a beneficial role in human diet and health. As many other medicinal plants, sea buckthorn can be contaminated with microorganisms which exerts an important impact on the overall quality of the products. Irradiation is an effective method for food preservation because it is able to destroy pathogenic microorganisms keeping the organoleptic and nutritional characteristics of the foods. The objective of the present study was to investigate the application of electron beam irradiation in order to improve the microbiological safety of sea buckthorn. The experimental results indicated that the electron beam treatment might be a good method to remove undesirable microorganisms from sea buckthorn without significant changes in its active principles.

2007-09-21

122

Understanding consumption-related sucralose emissions - A conceptual approach combining substance-flow analysis with sampling analysis  

British Library Electronic Table of Contents (United Kingdom)

This paper explores the potential of combining substance-flow modelling with water and wastewater sampling to trace consumption-related substances emitted through the urban wastewater. The method is exemplified on sucralose. Sucralose is a chemical sweetener that is 600 times sweeter than sucrose and has been on the European market since 2004. As a food additive, sucralose has recently increased in usage in a number of foods, such as soft drinks, dairy products, candy and several dietary products. In a field campaign, sucralose concentrations were measured in the inflow and outflow of the local wastewater treatment plant in Linkoping, Sweden, as well as upstream and downstream of the receiving stream and in Lake Roxen. This allows the loads emitted from the city to be estimated. A method c...

2010-01-01

123

The Role of Nutrition in the Etiology of Inflammatory Bowel Disease  

British Library Electronic Table of Contents (United Kingdom)

Many foods have been implicated in theories about the etiology of inflammatory bowel disease. While evidence has accumulated that nutritional factors as part of overall lifestyle changes may play a role in the growing incidence, no specific dietary recommendations except the promotion of breastfeeding can currently be given to decrease the risk of developing Crohn's disease or ulcerative colitis. For the treatment of Crohn's disease in children and adolescents, however, enteral feeding with a semi-elemental diet seems to be as effective as corticosteroids in inducing and maintaining remission. In the meta-analyses, advantages of one formula over the other are evened out, and more research is warranted into the anti-inflammatory properties of different nutrients, such as polyunsaturated fat...

2011-01-01

124

Reference materials to evaluate measurement systems for the nutrient composition of foods: results from USDA?s National Food and Nutrient Analysis Program (NFNAP)  

British Library Electronic Table of Contents (United Kingdom)

Over a 6.5-year period a total of 2554 values were reported by nine laboratories for 259 certified or reference nutrient concentrations in 26 certified reference materials (CRM) submitted to contract laboratories, blinded, as part of the qualifying process for analytical contracts and in the routine sample stream as part of the National Food and Nutrient Analysis Program. Each value was converted to a Z?-score, reflecting the difference from the assigned value related to the combined expected analytical uncertainty plus the uncertainty in the CRM value. Z?-scores >|3.0| were considered unacceptable. For some nutrients (Na, folate, dietary fiber, pantothenic acid, thiamin, tocopherols, carotenoids, monounsaturated, and polyunsaturated fatty acids), >20% of Z?-scores were >|3.0|. For total f...

2007-01-01

125

Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis  

British Library Electronic Table of Contents (United Kingdom)

Knee osteoarthritis (OA) is a common degenerative joint disorder and a major cause of pain and disability. The hypothesis tested in this study was that the passion fruit peel extract (PFP), a flavonoid-rich dietary supplement, would reduce symptoms due to knee OA. Thirty-three OA patients were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. Patients received either placebo or PFP pills (150 mg, daily) in a double-blinded fashion for 2 months. The OA clinical symptoms were evaluated monthly with Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index. In the PFP group, there was a significant improvement in total WOMAC score and WOMAC subscale score of physical function after 30 days and pain after 60 days. At 60 days, reductions o...

2010-01-01

126

Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma  

British Library Electronic Table of Contents (United Kingdom)

Asthma, affecting as many as 400 million individuals worldwide, is one of the most prevalent chronic health condition in the United States. With an increasing number of patients with asthma and the frequent inability of conventional lifestyle modification and therapy to effectively control the problem, nutritional and dietary therapies are being sought. This study was undertaken to investigate the efficacy of the purple passion fruit peel (PFP) extract, a novel mixture of bioflavonoids, on asthma symptoms. Patients with asthma were studied in a 4-week randomized, placebo-controlled, double-blind trial with oral administration of PFP extract (150 mg/d) or placebo pills. The effects of PFP extract were evaluated by assessing the clinical symptoms of asthma and spirometry tests. Most clinical...

2008-01-01

127

Green Tea Extract (Epigallocatechin-3-Gallate) Reduces Efficacy of Radiotherapy on Prostate Cancer Cells  

British Library Electronic Table of Contents (United Kingdom)

ObjectivesTo assess the influence of epigallocatechin-3-gallate (EGCG) on the efficacy of ionizing radiation on prostate cancer cells because of the increased use of dietary interventions, especially by patients with prostate cancer. Radiotherapy is used to treat localized prostate cancer. Some people consume green tea (EGCG) as a chemopreventive agent against prostate cancer. Green tea can act as an antioxidant and induce superoxide dismutase enzymes, which could scavenge the free oxygen radicals generated by radiotherapy. MethodsProstate cancer cell line DU145 cells were treated with EGCG or radiotherapy, or both. Cell death was assessed using trypan blue cell counting, and apoptosis was confirmed by assessing poly (adenosine phosphate ribose) polymerase cleavage. The antioxidant potenti...

2011-01-01

128

Gastrointestinal transit after transverse colostomy: study of solid radiopaque markers progression and others clinical and radiological events - analysis of 20 cases; Transito gastrintestinal apos fechamento de transversostomia: estudo atraves da progressao de marcadores solidos radiopacos e de outros eventos clinicos e radiologicos - analise de 20 casos  

Energy Technology Data Exchange (ETDEWEB)

The gastrointestinal transit was studied in 20 patients with loop transverse colostomies and previously normal colons. This analysis was performed through radiological observation of progression of 20 radiopaque pellets and measurements of its transit time in the various segments of the digestive tract. An evaluation of other related clinical and radiological events was carried out sentimentality's. In order to better understand the influence of the surgical procedure, the study was performed under similar dietary and supportive care conditions and standard radiological studies before and after the re-establishment of transit, thus enabling a comparison with the same individual. (author)

1988-07-01

129

Estimation of dietary intake of ochratoxin A from liquorice confectionery  

British Library Electronic Table of Contents (United Kingdom)

Ochratoxin A (OTA) was analyzed from 44 liquorice confectionery samples using immunoaffinity cleanup and liquid chromatography coupled with fluorescence detection. The presence of OTA was confirmed by methyl-ester derivatization. Liquorice confectionery samples were purchased from different retail outlets and supermarkets in Spain during 2007-2008, 16 of hard candies and 28 of soft candies. The incidence of OTA varied between 75% and 39% and mean ranged from 2.96 to 0.34mg/kg for hard and soft candies, respectively. Assuming a total mean value of 1.29mgOTA/kg sweet and a consumption of about 1.2g liquorice sweets per day, an OTA weekly uptake of 11ng was obtained, or, based on a total body weight of 30kg for a child consuming these sweets regularly, a weekly intake of 0.37ng/kg body weight...

2009-01-01

130

Effect of host nutrition on immunity and local immune response of rabbits to Obeliscoides cuniculi  

International Nuclear Information System (INIS)

In a series of experiments carried out on young and adult rabbits the effect of isocaloric low protein diets containing 4% or 8% protein compared with a diet containing 21% protein on Obeliscoides cuniculi infection was studied. The pathogenesis, resistance and local immunity were assessed after single infections with 10,000 larvae or reinfection with 5000 larvae. Live weight gain was reduced in young and adult rabbits fed the low protein diets, but the establishment of parasites was not substantially influenced by protein deprivation. However, development of worms in the histotrophic phase and parasite fecundity were impaired in association with the low protein diet. Moreover, mild anaemia as well as changes in the mucosal immune response as a result of infection were related to the level of dietary protein. (author). 30 refs, 6 figs, 5 tabs.

1987-05-11

131

Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule  

British Library Electronic Table of Contents (United Kingdom)

Excessive physical activity plays an important role in the progression of anorexia nervosa (AN) by accelerating weight loss during dietary restriction. To search for mechanisms underlying this trait, a panel of mouse chromosome substitution strains derived from C57BL/6J and A/J strains was exposed to a scheduled feeding paradigm and to voluntary running wheel (RW) access. Here, we showed that A/J chromosomes 4, 12 and 13 contribute to the development of a disrupted RW activity in response to daily restricted feeding. This pattern is characterized by intense RW activity during the habitual rest phase and leads to accelerated body weight loss. Regions on mouse chromosomes 4, 12 and 13 display homology with regions on human chromosomes linked with anxiety and obsessionality in AN cohorts. The...

2010-01-01

132

A Comparative Study of Pectin Extracted from Passion Fruit Rind Flours  

British Library Electronic Table of Contents (United Kingdom)

Brazil is the world?s main producer of passion fruit. Previous reports show that passion fruit rinds, an industrial waste, contain large amounts of pectin. Pectin is a dietary fiber that is widely used in the food industry as a gelling agent and stabilizer. In this study, the quality and characteristics of pectin extracted from yellow passion fruit rind flour was investigated. Pectin was extracted from both commercially available and prepared passion fruit peels using nitric acid. Once extracted, the pectin was evaluated for its molecular characteristics and chemical composition as well as for the apparent and reduced viscosity of the gel. Prepared (blanched) rind flour yielded 203.4?g?kg?1 of pectin, which contained a uronic acid content of 681?mg?g?1, a degree of esterification of 80, a ...

2010-01-01

135

Prediction of response of blood lead to airborne and dietary lead from volunteer experiments with lead isotopes  

Energy Technology Data Exchange (ETDEWEB)

To predict the response of blood lead to airborne and dietary lead requires knowledge of the rate of uptake of lead into the body from lung and gut, its subsequent partitioning between compartments, the stay time in those compartments, and its redistribution or excretion. Tracer studies with volunteers have shown no differences in systemic distribution of inorganic lead between tissues whether it is taken by inhalation, ingestion or injection. Lead is rapidly transferred from plasma to red cells, and there is slower movement thence into liver and other soft tissues, to bone, and to excreta. Work at Harwell and elsewhere with /sup 203/Pb has shown that the initial rapid distribution leaves rather over half the assimilated lead attached to red cells. The result is remarkably consistent, and applies also to dogs and baboons. The renal clearance (Vu) (ratio of U to CB, or daily urinary output expressed as mass of blood having the same lead content), and also the ...

1985-04-22

136

Methionine kinetics in adult men: effects of dietary betaine on L-[2H3-methyl-1-13C]methionine  

International Nuclear Information System (INIS)

The effects of a daily 3-g supplement of betaine on kinetic aspects of L-[2H3-methyl-1-13C]methionine (MET) metabolism in healthy young adult men were explored. Four groups of four subjects each were given a control diet, based on an L-amino acid mixture supplying 29.5 and 21.9 mg.kg-1.d-1 of L-methionine and L-cystine for 4 d before the tracer study, conducted on day 5 during the fed state. Two groups received the control diet and two groups received the betaine supplement. Tracer was given intravenously (iv) or orally. The transmethylation rate of MET (TM), homocysteine remethylation (RM), and oxidation of methionine were estimated from plasma methionine labeling and 13C enrichment of expired air. RM tended to increase (P = 0.14) but the TM and methionine oxidation were significantly (P less than 0.05) higher after betaine supplementation when estimated with the oral tracer. No differences were detected with the intravenous tracer. Methionine concentration in plasma obtained from ...

137

Elemental transfer from Chinese soil via the diet to the whole human body  

International Nuclear Information System (INIS)

Based on results from recent studies of elemental dietary intake and organ or tissue content for adult Chinese men, quoted nationwide elemental concentrations in Chinese soil and newly published national average consumption of dietary foods, values of both transfer coefficients and discrimination factor (DF) for transfer from soil via the diet to both critical organs and the whole body have been calculated for important elements in radiation protection, including alkaline earths, alkali metals, rare earths and other related elements. These calculations have used both the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) model and the DF method. In the UNSCEAR model, the basic parameters used to describe the transport of radionuclides are the transfer coefficients P_i_j, which describe the relationship of concentrations or other amounts between compartment i and the following compartment j, whereas the DF is the ...

2008-12-01

138

Effect of energy intake on the metabolism of glucose and glutamine in rumen epithelial tissue  

International Nuclear Information System (INIS)

Ten Holstein steers (579 kg average body weight) were fed either alfalfa hay (12.2% crude protein) or a 90% concentrate diet to supply 14.2 or 25.2 Mcal ME respectively for a minimum of 28 days. Samples of rumen epithelial tissue were removed at slaughter from the anterior ventral sac, washed free of feed particles and transported to the laboratory in oxygenated Krebs-Ringer bicarbonate buffer (KRB; pH 7.4). Papillae were weighed (100-200 mg) in triplicate into flasks containing 3 ml KRB with 1 mM glutamine or 5 mM glucose and acetate (50 mM), propionate (25 mM), butyrate (15 mM), lactate (1 mM) and glucose (5 mM) or glutamine (1 mM) as competing substrates. A parallel set of flasks contained 1 or .5 #mu#Ci of [U-"1"4C]-glutamine or glucose respectively for "1"4CO_2 production. There were no interactions with dietary energy intake and substrate addition. Increasing the dietary energy intake increased (P < .01) rates of uptake, "1"4CO_2 ...

1986-04-13

139

Dietary energy requirements of young adult men, determined by using the doubly labeled water method  

International Nuclear Information System (INIS)

The autors examined the hypothesis that current recommendations on dietary energy requirements may underestimate the total energy needs of young adult men, by measuring total energy expenditure (TEE) and resting energy expenditure (REE) in 14 weight-maintaining healthy subjects leading unrestricted lives. TEE and body composition were measured by using 2H(2)18O, and REE was measured by using indirect calorimetry. All subjects had sedentary full-time occupations and participated in strenuous leisure activities for 34 #+-# 6 (SE) min/d. TEE and REE were 14.61 #+-# 0.76 and 7.39 #+-# 0.26 MJ/d, respectively, and 202 #+-# 2 and 122 #+-# 2 kJ.kg-1.d-1. There were significant relationships between TEE and both body fat-free mass (r = 0.732, P less than 0.005) and measured REE (r = 0.568, P less than 0.05). Measured TEE:REE values were significantly higher than the recommended energy requirement (1.98 #+-# 0.09, compared with 1.55 or 1.67, P less than 0.005). These ...

140

Application of the elemental contents in diet, organ or tissues and urine for Chinese adult men in radiation protection  

International Nuclear Information System (INIS)

Objective: To apply the obtained results from 3 stages of research in Chinese radiation protection field. Methods: Based on the identification of physical, chemical and biological qualities for element and its radionuclides under equilibrium condition, main application of these results in Chinese radiation protection field have been discussed by using reported methods in literature. Results: Based on developing elemental reference values of organs or tissues, whole body burdens and their distribution for Chinese Reference Man, discussed in the above 3 articles, current dietary elemental intakes of 42 elements have been updated, and related basis for certain important parameters of bio-kinetic model for use in radiation protection (for example, f_l, T_e and T_b) have been provided. The internal doses from primordial radionuclides and transfer coefficients of elements from environment into the critical organs of Chinese adult men have been estimated. Conclusions: The ...

2007-08-01

141

Robust consensus clustering for identification of expressed genes linked to malignancy of human colorectal carcinoma  

UK PubMed Central (United Kingdom)

Previous studies have been conducted in gene expression profiling to identify groups of genes that characterize the colorectal carcinoma disease. Despite the success of previous attempts to identify...Full Text Available

142

Multilevel support vector regression analysis to identify condition-specific regulatory networks  

UK PubMed Central (United Kingdom)

Motivation: The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify...Full Text Available

2010-06-01

143

Light duty utility arm startup plan  

Energy Technology Data Exchange (ETDEWEB)

This plan details the methods and procedures necessary to ensure a safe transition in the operation of the Light Duty Utility Arm (LDUA) System. The steps identified here outline the work scope and identify responsibilities to complete startup, and turnover of the LDUA to Characterization Project Operations (CPO).

1998-09-01

144

Large-scale cross-species oncogenomics identifies candidate oncogenes and tumor suppressor genes  

UK PubMed Central (United Kingdom)

While genomic alterations identified in human tumors using techniques such as comparative genomic hybridisation (CGH) may be recurrent, they frequently encompass large regions, in some cases...Full Text Available

2010-02-01

145

Intelligent techniques applied in identifying fraudsters industrial consumers of electricity; Tecnicas inteligentes aplicadas na identificacao de consumidores industriais fraudadores de energia eletrica  

Energy Technology Data Exchange (ETDEWEB)

The development of a computational intelligent tools based on neural network to identify commercial losses or fraud (theft energy), considering information from a database electric utility, is presented.

2009-07-01

146

How and when can one identify hadronic molecules in the baryon spectrum  

Energy Technology Data Exchange (ETDEWEB)

A method to identify hadronic molecules in the particle spectrum is reviewed and the conditions for its applicability discussed. Special emphasis is put on the discussion of molecule candidates in the baryon spectrum. (orig.)

2008-03-15

147

Contingency Space Analysis: An Alternative Method for Identifying Contingent Relations from Observational Data  

UK PubMed Central (United Kingdom)

Descriptive assessment methods have been used in applied settings to identify consequences for problem behavior, thereby aiding in the design of effective treatment programs. Consensus has not been...Full Text Available

2008-01-01

148

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer  

UK PubMed Central (United Kingdom)

Cancers are highly heterogeneous and contain many passenger and driver mutations. To functionally identify tumor suppressor genes relevant to human cancer, we compiled pools of short harpin...Full Text Available

2008-11-28

149

A DNA transposon-based approach to validate oncogenic mutations in the mouse  

UK PubMed Central (United Kingdom)

Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available

2008-12-16

150

45 CFR 162.404 - Compliance dates of the implementation of the standard unique health identifier for health care...  

Science.gov (United States)

...dates of the implementation of the standard unique health identifier for health care providers. 162.404 Section 162.404 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA...

2010-10-01

151

The DIVAD Archaeological Project  

Science.gov (United States)

... Like other surveys in the Hueco Bolson (Carmichael 1983; Whalen 1977, 1978), the BLM survey identified large concentrations of Pueblo period ...

2011-05-14

152

DIGITAL LIBRARIES: IMPACT ON SCIENCE ... - MUSPIN - NASA  

Science.gov (United States)

digital libraries, which was identified as a national challenge in the Information ... The linkages between the many digital libraries and information services are ...

153

Cartridge Cases  

Science.gov (United States)

... reverse aeb 9 nescesmsy amI identify by block number) Provides procedures for evaluating metal, consumable, and combustible cartridge cases. ...

1980-10-21

154

Aviation Maintenance Safety Articles, January/February 1990  

Science.gov (United States)

... These are abnormal and an indication of NAVAIRINST 13340.3 identifies these laboratories a possible breakdown in the fuel-handling equip- ...

1990-02-01

155

Industrial waste and pollution in Mongolia  

Energy Technology Data Exchange (ETDEWEB)

This paper very briefly outlines hazardous waste management issues, including regulations, in Mongolia. Air, water, and soil pollutants are identified and placed in context with climatic, social, and economic circumstances. The primary need identified is technology for the collection and disposal of solid wastes. Municipal waste problems include rapid urbanization and lack of sanitary landfills. Industrial wastes of concern are identified from the mining and leather industries. 4 refs., 2 tabs.

1996-12-31

156

Tumor necrosis factor alpha and interleukin-1 stimulate bone resorption in vivo as measured by urinary ( sup 3 H)tetracycline excretion from prelabeled mice  

Energy Technology Data Exchange (ETDEWEB)

Tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) have been shown to stimulate bone resorption in vitro. We have now investigated whether these cytokines also cause a similar action when administered in vivo. This was made possible by the adaptation of a newly developed technique that enables the continual assessment of bone resorption in vivo in mice by measuring urinary excretion of {sup 3}H from ({sup 3}H)tetracycline-prelabeled animals. Experiments using maneuvers known to influence bone resorption, such as a change in dietary calcium or administration of parathyroid hormone or dichloromethylenebisphosphonate, indicate that the technique is reliable and sensitive in mice. Daily intravenous administration of either recombinant human or recombinant murine TNF-alpha, as well as subcutaneous administration of recombinant human IL-1 alpha, were found to stimulate bone resorption in a dose-dependent manner. The effect was maximal within 2 days. Thus, ...

1988-12-01

157

Replacement of fishmeal in cobia (Rachycentron canadum) diets using poultry by-product meal  

British Library Electronic Table of Contents (United Kingdom)

An 8-week feeding trial was conducted to evaluate the use of local poultry by-product meal (PBM) in replacement of imported fishmeal in the diets of cobia, Rachycentron canadum. Six isolipidic (12%) and isoproteic (45%) experimental diets were formulated using PBM to replace fishmeal at 20, 40, 60, 80 and 100% dietary protein. Eleven juvenile cobia (initial mean weight of 30.7???0.78?g) were randomly stocked in 300-L circular fibreglass tanks and hand-fed based on the total biomass of each tank, twice a day at 0900?h and 1500?h. The fish were group weighed at 2-week intervals to monitor their growth performance in order to adjust the feeding ratio. At the end of the feeding trial, weight gains (WGs) ranging from 221 to 322% were obtained. The specific growth rate (SGR), WG and protein effi...

2011-01-01

158

Morphological development of larval cobia Rachycentron canadum and the influence of dietary taurine supplementation  

British Library Electronic Table of Contents (United Kingdom)

The morphological development of larval cobia Rachycentron canadum from 3 days post hatch (dph) until weaning (27 dph) was examined using S.E.M. Two groups of fish were studied: a control group (CF), reared under standard feeding protocol, and a group in which prey items were enriched with supplemental taurine (4 g l-1 day-1; TF). TF fish grew faster (P < 0001), attained greater size (mean s.e. 551 15 v. 339 10 mm total length) and had better survival (mean s.e. 293 04 v. 71 12 %) than CF fish. Canonical variance analysis confirmed findings with respect to differences in growth between the treatment groups with separation being explained by two cranial measurements. S.E.M. revealed that 3 dph larvae of R. canadum (in both groups) possess preopercular spines, superficial neuromasts on the h...

2011-01-01

159

Free amino acid distribution in plasma and liver of juvenile cobia (Rachycentron canadum) fed increased levels of lizardfish silage  

British Library Electronic Table of Contents (United Kingdom)

Abstract Juvenile cobia (Rachycentron canadum) (100-g) were fed four moist diets (447-476-g-kg-1-dry-wt) where 0, 130, 260 or 390-g-kg-1 of concentrated lizardfish (Saurida undosquamis) silage replaced fresh lizardfish, respectively. Blood and livers were sampled at 0, 6, 12, 24 and 48-h postfeeding at the end of the 3-week experiment. At 6-h postfeeding in all groups, maximum concentrations of most plasma essential amino acids were observed, while significantly lower levels of most non-essential amino acid levels were recorded compared to the other sampled times. At 6 and 12-h after feeding, the concentration of most plasma free amino acid (FAA) increased with an increase in dietary fish silage levels. Most FAA in livers of all groups peaked at 12 and 24-h postfeeding. However, at 48-h po...

2011-01-01

160

Elemental investigation of Syrian medicinal plants using PIXE analysis  

Energy Technology Data Exchange (ETDEWEB)

Particle induced X-ray emission (PIXE) technique has been employed to perform elemental analysis of K, Ca, Mn, Fe, Cu, Zn, Br and Sr for Syrian medicinal plants used traditionally to enhance the body immunity. Plant samples were prepared in a simple dried base. The results were verified by comparing with those obtained from both IAEA-359 and IAEA-V10 reference materials. Relative standard deviations are mostly within {+-}5-10% suggest good precision. A correlation between the elemental content in each medicinal plant with its traditional remedial usage has been proposed. Both K and Ca are found to be the major elements in the samples. Fe, Mn and Zn have been detected in good levels in most of these plants clarifying their possible contribution to keep the body immune system in good condition. The contribution of the elements in these plants to the dietary recommended intakes (DRI) has been evaluated. Advantages and limitations of PIXE analytical technique in this ...

2010-09-15

161

Dietary Cholesterol and Prostate Cancer Risk: Inhibition of prostate Cancer in Rats by the Administration of some Antioxidants  

International Nuclear Information System (INIS)

The present work was carried out to illuminate the relation between high cholesterol diet and incidence of prostate caner. Also, in this study, the effect of DHEA, selenium or oxygen therapy were tested in order to show to what extent they are valid to ameliorate the deleterious effects of prostate cancer. The obtained results revealed that prostate cancer caused a significant (p<0.01) elevation of TAP, PAP, PSA, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol and prostate COX-2, whereas, testosterone, free testosterone, DHEA-S, FT_4 and FT_3 were decreased significantly as compared with the corresponding levels in control rats in both normal and high cholesterol diet. Supplementation of DHEA, selenium or oxygen therapy ameliorated all variables recorded herein but, their values did not revert to normal. Any how, the results of this investigation showed that the above mentioned antioxidants possess potential benefits in lessening number of risk factors in blood ...

2009-07-01

162

Chemical Composition and Nutritional Value of Unripe Banana Flour (Musa acuminata, var. Nanic?o)  

British Library Electronic Table of Contents (United Kingdom)

Banana flour obtained from unripe banana (Musa acuminata, var. Nanic?o) under specific drying conditions was evaluated regarding its chemical composition and nutritional value. Results are expressed in dry weight (dw). The unripe banana flour (UBF) presented a high amount of total dietary fiber (DF) (56.24?g/100?g), which consisted of resistant starch (RS) (48.99?g/100?g), fructans (0.05?g/100?g) and DF without RS or fructans (7.2?g/100?g). The contents of available starch (AS) (27.78?g/100?g) and soluble sugars (1.81?g/100?g) were low. The main phytosterols found were campesterol (4.1?mg/100?g), stigmasterol (2.5?mg/100?g) and ?-sitosterol (6.2?mg/100?g). The total polyphenol content was 50.65?mg GAE/100?g. Antioxidant activity, by the FRAP and ORAC methods, was moderated, being 358.67 an...

2011-01-01

163

Bioavailability of lead in rats fed human diets  

International Nuclear Information System (INIS)

The bioavailability of lead was studied in rats fed various baby foods (Babymix-turkey, Babymix-vegetables, Frutolino-fruit, Frutamix-bananas, Babyron-S-26, Truefood), cow's milk, bread, liver and standard rat diet. Lead absorption was determined by measuring the whole body retention of "2"0"3Pb 6 days after a single oral application. Highest absorption values ranging from 17 to 20% were obtained in animals fed cow's milk and fruit foods. Rats on other human diets absorbed between 3 and 8% of the radioactive lead dose. Only in animals on rat diet lead absorption was below 1%. It is concluded that rats fed human diets show absorption values similar to those in humans. This might indicate that the bioavailability of lead is primarily dependent on dietary habits. This experimental model, if confirmed by further work, might be useful for obtaining preliminary data on the bioavailability of metals from various foods.

164

Bioaccumulation of trace metals in farmed fish from South China and potential risk assessment  

British Library Electronic Table of Contents (United Kingdom)

Concentrations of trace metals were determined in water, sediment, fish feed and two species of farmed fish, pompano and snapper, collected from Daya Bay and Hailing Bay of South China in July 2007 and January 2008. Total average concentrations of Cu, Pb, Zn, Cd, Cr, Hg and As were 1.6, 2.7, 27.3, 0.025, 0.62, 0.18 and 0.59?g/gdrywt in pompano and 1.5, 2.6, 23.6, 0.020, 0.55, 0.22 and 0.53?g/gdrywt in snapper. In general, the concentrations of all target metals except Hg were positively correlated with lipid contents whereas negative correlations were observed between the metal concentrations and fish body weights. Model calculation indicated that dietary uptake of Zn and Cd predominate their accumulation in snapper, accounting for 99.9% and 98.2% of the total inputs. Risk ...

2011-01-01

165

Automated segmentation and quantitative characterization of radiodense tissue in digitized mammograms  

International Nuclear Information System (INIS)

Mammography has emerged as a reliable non-invasive technique for the early detection of breast cancer--the second leading cause of cancer-related mortality among American women. The radiographic appearance of the female breast consists of radiolucent (dark) regions due to fat and radiodense (light) regions due to connective and epithelial tissue. The amount of radiodense tissue can be used as a marker for predicting breast cancer risk. This paper presents the development of an algorithm for estimating the percentage of radiodense tissue in a digitized mammogram. The technique involves determining a dynamic threshold for segmenting radiodense indications in mammograms. Both the mammographic image and the threshold are modeled as Gaussian random variables. This work is intended to support a concurrent study at the Fox Chase Cancer Center (FCCC) exploring the association between dietary patterns and breast cancer risk. Mammograms have been obtained from an existing ...

2002-05-25

166

Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid.  

Science.gov (United States)

Recent findings that many human chronic diseases are associated with oxidative stresses have instigated the search for dietary antioxidants. Many phytochemicals, particularly phenolic compounds, have been found to possess strong antioxidant activity and reduce the risks of those diseases. Isoflavones, a special phenolic group found in soybean, have been found to act as antioxidants in some model systems. This study investigated the isoflavone content in a unique nonedible tree fruit, Osage orange [Maclura pomifera (Raf.) Schneid], and methods for the extraction, identification, and quantification of the two major isoflavones, osajin and pomiferin, were developed. The ethyl acetate extract contained 25.7% osajin and 36.2% pomiferin, and the two isoflavones were at 9.5 g kg(-1) of fresh Osage orange. Two model systems, FRAP and beta-CLAMS, were used to measure the antioxidant activity of these two isoflavones. Pomiferin was found to be a strong antioxidant in both ...

2003-10-22

167

Technical area status report for chemical/physical treatment. Volume 2, Appendices  

Energy Technology Data Exchange (ETDEWEB)

These Appendices describe various technologies that may be applicable to the Mixed Waste Treatment Plant (MWTP) Chemical/Physical Treatment System (CPTS). These technologies were identified by the CPTS Technical Support Group (TSG) as potentially applicable to a variety of separation, volume reduction, and decontamination requirements. The purpose was to identify all available and developing technologies, and their characteristics, for subsequent evaluation for specific requirements identified for the CPTS. However, the technologies described herein are not necessarily all inclusive, nor are they necessarily all applicable.

1993-08-01

168

Nuclear fuel assembly identification using computer vision  

Science.gov (United States)

This report describes an improved method of remotely identifying irradiated nuclear fuel assemblies. The method uses existing in-cell TV cameras to input an image of the notch-coded top of the fuel assemblies into a computer vision system, which then produces the identifying number for that assembly. This system replaces systems that use either a mechanical mechanism to feel the notches or use human operators to locate notches visually. The system was developed for identifying fuel assemblies from the Fast Flux Test Facility (FFTF) and the Clinch River Breeder Reactor, but could be used for other reactor assembly identification, as appropriate.

1985-11-01

169

MEG studies of human vision: Retinotopic organization of V1  

Energy Technology Data Exchange (ETDEWEB)

A primary goal of noninvasive studies of human vision is to identify and characterize multiple visual areas in the human brain analogous to those identified in studies of nonhuman primates. By combining functional MEG measurements with images of individual anatomy derived from MRI, the authors hope to determine the location and arrangement of multiple visual areas in human cortex and to probe their functional significance. The authors have identified several different visual areas thus far which appear to be topographically organized. This paper focuses on the retinotopic characterization of the primary visual area (V1) in humans.

1993-12-31

170

sUAS Presentation 26June08.ppt  

Science.gov (United States)

Jun 26, 2008 ... NAVAIRINST 13034.1C. ACC/ARC/ NAT IPT/EDT ENGINEERING. OWNER. FLEET. REQUIREMENT. IDENTIFIED. PROGRAM INITIATED ...

171

Timber Compartment Boundary  

Science.gov (United States)

Timber Compartment Boundary This data set identifies the 90 timber compartment boundaries in a 200 square-mile study ... Kawishiwi Ranger Districts, Superior National ...

173

The early phase change Gene in Maize  

UK PubMed Central (United Kingdom)

Recessive mutations of the early phase change (epc) gene in maize affect several aspects of plant development. These mutations were identified initially because of...Full Text Available

2002-01-01

174

The Physical Attractiveness of Electronic Physician Notes  

UK PubMed Central (United Kingdom)

Though notes in electronic medical record systems (EMRs) have advantages, they are often criticized for their unattractive and unprofessional appearance. We sought to identify notes regarded by physicians...Full Text Available

2010-01-01

175

The I3I Model; Identifying Cultural Determinants of Information ...  

Science.gov (United States)

... Information behavior in dynamic group work contexts: Interwoven situational awareness, dense social networks and contested collaboration in ...

2009-06-01

176

The Financial War on Terrorism: Grading US Strategy for ...  

Science.gov (United States)

... that operated in Pakistan, Dubai, and throughout the Middle East ... identifies 'funds' as one of eight major terrorist ... techniques, and procedures (TTP). ...

2006-04-15

177

Survey of non-prescribed use of antibiotics for children in an urban community in Mongolia  

UK PubMed Central (United Kingdom)

AbstractObjectiveTo estimate the prevalence and identify the determinants of non-prescription use of antibiotics for children in Mongolia.MethodsA...Full Text Available

2010-12-01

178

Social, Clinical and Microbiological Differential Characteristics of Tuberculosis among Immigrants in Spain  

UK PubMed Central (United Kingdom)

BackgroundTo identify the differential tuberculosis (TB) characteristics within the immigrant population with respect to natives in Spain.Methodology/Principal...Full Text Available

179

Science and technology for industrial ecology  

Energy Technology Data Exchange (ETDEWEB)

This paper first discusses the challenge offered by natural and anthropogenic systems in all of their complexity and then indicates some areas of research in which specific scientific and technological needs are identifiable.

1996-07-10

180

Role of Orvosi Hetilap in the development of Hungarian gastroenterology  

UK PubMed Central (United Kingdom)

AIM: To analyze the contribution of Orvosi Hetilap (Hungarian Medical Journal) to the field of gastroenterology.METHODS: All issues of the journal between 1857 and 2008 and identified...Full Text Available

2010-05-14

181

Report of the Geostatistical Analysis of High Resolution ...  

Science.gov (United States)

... The variogram analysis of the high resolution imagery has shown that although more spatial scales have been identified than from the SPOT image ...

1998-05-01

182

Plasmid-Determined Copper Resistance in Pseudomonas syringae from Impatiens  

UK PubMed Central (United Kingdom)

A strain of Pseudomonas syringae was recently identified as the cause of a new foliar blight of impatiens. The bacterium was resistant to copper compounds, which are used on a variety...Full Text Available

1990-01-01

183

Physiologic changes during growth and development.  

UK PubMed Central (United Kingdom)

To express growth-related changes in physiologic or other functions in forms usable for kinetic modeling, we are interested in identifying regular relationships that take the form of simple mathematical...Full Text Available

1994-12-01

184

Patient persistence with first-line antiglaucomatous monotherapy  

UK PubMed Central (United Kingdom)

PurposeTo identify the extent of persistence (period of time of continuous therapy with the drug prescribed) of glaucoma patients treated with prostaglandins (latanoprost, bimatoprost,...Full Text Available

2010-01-01

185

Optimization for Vibration Isolation.  

Science.gov (United States)

An almost linear optimization problem of importance in vibration isolation has been identified and algorithms were developed to minimize the forced vibrational response of structural systems. The constraints can be either displacements of accelerations. T...

1983-01-01

186

Mutations in RNA Binding Protein Gene Cause Familial Dilated Cardiomyopathy  

UK PubMed Central (United Kingdom)

ObjectivesWe sought to identify a novel gene for dilated cardiomyopathy (DCM).BackgroundDCM is a heritable, genetically...Full Text Available

2009-09-01

187

Medical Conditions of Nursing Home Admissions  

UK PubMed Central (United Kingdom)

BackgroundAs long-term nursing home care is likely to increase with the aging of the population, identifying chronic medical conditions is of particular interest. Although need factors...Full Text Available

188

Measurement methods for human exposure analysis.  

UK PubMed Central (United Kingdom)

The general methods used to complete measurements of human exposures are identified and illustrations are provided for the cases of indirect and direct methods used for exposure analysis. The application...Full Text Available

1995-04-01

190

Factors Linked to Bacterial Vaginosis in Nonpregnant Women  

UK PubMed Central (United Kingdom)

Objectives. The purposes of this study were to test the hypothesis that vaginal douching is linked to bacterial vaginosis in both symptomatic and asymptomatic women and to identify...Full Text Available

2001-10-01

191

Facilities evaluation report  

Energy Technology Data Exchange (ETDEWEB)

The Buried Waste Integrated Demonstration (BWID) is a program of the Department of Energy (DOE) Office of Technology Development whose mission is to evaluate different new and existing technologies and determine how well they address DOE community waste remediation problems. Twenty-three Technical Task Plans (TTPs) have been identified to support this mission during FY-92; 10 of these have identified some support requirements when demonstrations take place. Section 1 of this report describes the tasks supported by BWID, determines if a technical demonstration is proposed, and if so, identifies the support requirements requested by the TTP Principal Investigators. Section 2 of this report is an evaluation identifying facility characteristics of existing Idaho National Engineering Laboratory (INEL) facilities that may be considered for use in BWID technology demonstration activities.

1992-04-01

192

Coping Strategies of Family Members of Hospitalized Psychiatric Patients  

UK PubMed Central (United Kingdom)

This exploratory research paper investigated the coping strategies of families of hospitalized psychiatric patients and identified their positive and negative coping strategies. In this paper, the coping...Full Text Available

2011-01-01

193

Computer Vision Hardware System for Automating Rough Mills of Furniture Plants  

Science.gov (United States)

... company. To automate this initial cutup requires a computer vision system that can locate and identify surface defects ... ...

194

Characterization of a mycovirus associated with the brown discoloration of edible mushroom, Flammulina velutipes  

UK PubMed Central (United Kingdom)

BackgroundA mycovirus previously identified in brown discolored fruiting bodies of the cultivated mushroom Flammulina velutipes was characterized. We tentatively...Full Text Available

195

Cartridge Cases.  

Science.gov (United States)

This report provides procedures for evaluating metal, consumable, and combustible cartridge cases. It identifies supporting tests, facilities, and equipment required. Subtests include weapon and ammunition preparation, initial inspection, ammunition chara...

1980-01-01

196

Biosynthesis and metabolism of salicylic acid.  

UK PubMed Central (United Kingdom)

Pathways of salicylic acid (SA) biosynthesis and metabolism in tobacco have been recently identified. SA, an endogenous regulator of disease resistance, is a product of phenylpropanoid metabolism formed...Full Text Available

1995-05-09

197

Biogenesis of the Protein Storage Vacuole Crystalloid  

UK PubMed Central (United Kingdom)

We identify new organelles associated with the vacuolar system in plant cells. These organelles are defined biochemically by their internal content of three integral membrane proteins: a chimeric reporter...Full Text Available

2000-08-21

198

Alpha-toxin of Staphylococcus aureus.  

UK PubMed Central (United Kingdom)

Alpha-toxin, the major cytotoxic agent elaborated by Staphylococcus aureus, was the first bacterial exotoxin to be identified as a pore former. The protein is secreted as a single-chain, water-soluble...Full Text Available

1991-12-01

199

49 CFR 130.11 - Communication requirements.  

Science.gov (United States)

...identified as oil when the shipment document accurately describes the material as: aviation fuel, diesel fuel, fuel oil, gasoline, jet fuel, kerosene, motor fuel, or...

2010-10-01

200

Watching Systems in graphs: an extension of Identifying Codes  

CERN Document Server

We introduce the notion of watching systems in graphs, which is a generalization of that of identifying codes. We give some basic properties of watching systems, an upper bound on the minimum size of a watching system, and results on the graphs which achieve this bound; we also study the cases of the paths and cycles, and give complexity results.

2010-01-01

201

Sources of toxicity and exposure information for identifying chemicals of high concern to children  

International Nuclear Information System (INIS)

Due to the large number of chemicals in commerce without adequate toxicity characterization data, coupled with an ineffective federal policy for chemical management in the United States, many states are grappling with the challenge to identify toxic chemicals that may pose a risk to human health and the environment. Specific populations (e.g., children, elderly) are particularly sensitive to these toxic chemicals. In 2008, the Children's Safe Product Act (CSPA) was passed in Washington State. The CSPA included specific requirements to identify High Priority Chemicals (HPCs) and Chemicals of High Concern to Children (CHCCs). To implement this legislation, a methodology was developed to identify HPCs from authoritative scientific and regulatory sources on the basis of toxicity criteria. Another set of chemicals of concern was then identified from authoritative sources, based on their potential exposure to ...

2010-11-01

202

Molecular cloning of the N-terminus of GTBP  

Energy Technology Data Exchange (ETDEWEB)

Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5{prime} terminus, allowing definition of the entire coding region. Several polymorphisms within the 5{prime} end were identified and are presented. 13 refs., 1 fig.

1996-02-01

203

Identifying the Key Weaknesses in Network Security at Colleges.  

Science.gov (United States)

A new study identifies and ranks the 10 security gaps responsible for most outsider attacks on college computer networks. The list is intended to help campus system administrators establish priorities as they work to increase security. One network security expert urges that institutions utilize multiple security layers. (DB)

1999-12-01

204

Identification of unusual Campylobacter-like isolates from poultry products as Helicobacter pullorum  

DEFF Research Database (Denmark)

Twenty-six unclassified Campylobacter-like strains previously isolated from 15 chicken carcasses and caecal contents, together with two more strains isolated from chicken faeces on a different occasion, were identified as Helicobacter pullorum using various phenotypic identification methods. API Campy identification kits and a 16-test identification scheme developed for campylobacters failed to identify these bacteria, or identified them as Campylobacter spp. Eighteen strains (including the two isolated on a different occasion) were chosen for examination using a more comprehensive probabilistic identification scheme. Using this method, 14 of the 18 strains were identified as H. pullorum with ID scores > 95%; two strains were also identified as H. pullorum with lower ID scores. Of the remaining two strains, one was not identified with this scheme and the ...

1998-01-01

205

Epidemiological and clinical features of 1,149 persons with Lyme disease identified by laboratory-based surveillance in Connecticut.  

UK PubMed Central (United Kingdom)

Laboratory-based surveillance of Lyme disease in Connecticut during 1984 and 1985 identified 3,098 persons with suspected Lyme disease; 1,149 were defined as cases. Lyme disease incidence in Connecticut...Full Text Available

1989-05-01

206

Design study of copper toroidal field coils with bow shaping, demountable sliding joints, and active liquid-nitrogen cooling  

International Nuclear Information System (INIS)

The motivation for this design study has been to identify magnet designs for useful magnetic fusion experiments which minimize capital cost. Some possibly useful novel design features have been identified. 5 refs., 6 figs., 3 tabs.

1996-06-16

207

CFCC radiant burner assessment. Final report, April 1, 1992--July 31, 1994  

Energy Technology Data Exchange (ETDEWEB)

The objective of this work was to identify methods of improving the performance of gas-fired radiant burners through the use of Continuous Fiber Ceramic Composites (CFCCs). Methods have been identified to improve the price and performance characteristics of the porous surface burner. Results are described.

1994-11-01

208

Unrefined and refined black raspberry seed oils significantly lower triglycerides and moderately affect cholesterol metabolism in male Syrian hamsters.  

Science.gov (United States)

Abstract Unrefined and refined black raspberry seed oils (RSOs) were examined for their lipid-modulating effects in male Syrian hamsters fed high-cholesterol (0.12% g/g), high-fat (9% g/g) diets. Hamsters fed the refined and the unrefined RSO diets had equivalently lower plasma total cholesterol and high-density lipoprotein (HDL) cholesterol in comparison with the atherogenic coconut oil diet. The unrefined RSO treatment group did not differ in liver total and esterified cholesterol from the coconut oil-fed control animals, but the refined RSO resulted in significantly elevated liver total and esterified cholesterol concentrations. The unrefined RSO diets significantly lowered plasma triglycerides (46%; P=.0126) in comparison with the coconut oil diet, whereas the refined RSO only tended to lower plasma triglyceride (29%; P=.1630). Liver triglyceride concentrations were lower in the unrefined (46%; P=.0002) and refined (36%; P=.0005) RSO-fed animals than the coconut oil group, with the ...

2011-05-06

209

Turnover of whole body proteins and myofibrillar proteins in middle-aged active men  

International Nuclear Information System (INIS)

Endurance-trained older men have a higher proportion of lean tissue and greater muscle cell oxidative capacity, reversing age-related trends and suggesting major changes in protein metabolism. In this study, protein turnover was determined in 6 middle-aged (52+/-1 yr) men who were well trained (VO_2 max 55.2+/-5.0 ml O_2/kg.min) and lean (body fat 18.9+/-2.8%, muscle mass 36.6+/-0.6%). The maintained habitual exercise while consuming 0.6, 0.9 or 1.2 g protein/kg.day for 10-day periods. N flux was measured from "1"5N in urea after oral "1"5N-glycine administration. Myofibrillar protein breakdown was estimated from urinary 3-methyl-histidine. Dietary protein had no effect on turnover rates, even when N balance was negative. Whole body protein synthesis was 3.60+/-0.12 g/kg.day and breakdown was 3.40+/-0.14 g/kg.day for all N intakes. Whole body protein flux, synthesis and breakdown were similar to values reported for sedentary young (SY) or sedentary old (SO) men on ...

1986-04-13

210

Trace element intake and status of Italian subjects living in the Gubbi area  

International Nuclear Information System (INIS)

Daily intakes of certain trace elements (Pb, Cd, Ni, Hg, and Cr) were assessed using dietary history and weighed record methods and concurrent chemical analysis (CA) of duplicate portions, along with blood levels, in a group (21 M, 23 F) of inhabitants of the Gubbio area (Belvedere, Biscina Scritto). The evaluation of only intake of trace elements was accomplished in 40 subjects (20 M, 20 F) 1 year later. In both surveys, trace element intakes were generally lower than the potential tolerable weekly intake. However, daily intakes of Pb, Cd, Ni, Hg, and Cr were higher in men compared to women in both surveys (P<0.05). In fact, intakes at the 50th percentile were greater in men by approximately 75% for Pb, 91% for Cd, 20% for Ni, 45% fo Hg, and 29% for Cr in the first survey. In the second survey, percentage differences for Pb, Cd, Ni, and Cr were about 12%, 28%, 26%, and 26%, respectively. Blood trace element levels were slightly higher in men in th first survey. ...

2003-02-01

211

The story of iodine deficiency: An international challenge in nutrition  

International Nuclear Information System (INIS)

Iodine deficiency is a risk factor for the growth and development of up to 800 million people living in iodine deficient environments throughout the world. The effects on growth and development, called the iodine deficiency disorders (IDD), comprise goiter, stillbirths and miscarriages, neonatal and juvenile thyroid deficiency, dwarfism, mental defects, deaf mutism, and spastic weakness and paralysis, as well as lesser degrees of loss of physical and mental function. All these effects are due to inadequate thyroid hormone production because iodine is an essential constituent of the thyroid hormone. In the West, IDD has been largely eliminated by the addition of iodine to the diet through iodized salt or through changes in food distribution and technology. IDD still persists in certain areas of Europe where these dietary changes have not occurred. In the Third World, IDD is a major problem in many countries with large populations, such as China, India, Indonesia, ...

212

Radioactive lead studies in the human  

International Nuclear Information System (INIS)

The differing susceptibility of individuals to the toxic effects of chronic lead exposure has never been fully understood. As the major intake of lead in the human is from food and beverages, any variation between individuals of the quantity of lead absorbed from the gut, and of the distribution and excretion of this lead, may account for the differences in individual susceptibility. The food and beverages themselves may have an influence, and to investigate their effects on absorption, distribution and excretion of lead, experiments were performed on normal subjects using a short lived radionuclide of lead, "2"0"3Pb, and instruments generally available in Nuclear Medicine. Lead absorption between different individuals showed a wide variation when "2"0"3Pb was taken as a single dose between meals. Minerals were found to be mainly responsible for affecting absorption when one subject ingested "2"0"3Pb in control meals from which one dietary constituent at a time was ...

213

Phytochemical composition and biological activity of 8 varieties of radish (Raphanus sativus L.) sprouts and mature taproots.  

Science.gov (United States)

Radishes (Raphanus sativus L.) are members of the cruciferous vegetable family that contain many classes of biologically active phytochemicals. This study determined the phytochemical composition of the sprouts and mature taproots of 8 radish varieties. Radish sprouts contained significantly greater concentrations of glucosinolates (3.8-fold) and isothiocyanates (8.2-fold) than the mature radish taproot and also contained significantly greater concentrations of phenolics (on average 6.9-fold). The anthocyanin concentrations of the mature radish taproot were significantly greater than in the sprouts of red, pink, and purple varieties. The primary anthocyanidins present in the red and pink radish varieties were pelargonidin and delphinidin, while the primary anthocyanidin in the purple radish variety was cyanidin. Radish sprouts were between 9- and 59-fold more potent than the corresponding mature taproot at activating the antioxidant response element (ARE) in a stably transfected ...

214

Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin.  

Science.gov (United States)

Pancreatic amyloid deposits of amylin are a hallmark of Type II diabetes and considerable evidence indicates that amylin oligomers are cytotoxic to beta-cells. Many efforts are presently spent to find out naturally occurring molecules, or to design synthetic ones, able to hinder amylin aggregation or to protect cells against aggregate cytotoxicity. In this context, a protective effect of some polyphenols against amyloid cytotoxicity was reported. Actually dietary polyphenols are endowed with multiple health benefits, and extra virgin olive oil is attracting increasing interest as a source of these substances. Here, we investigated the effects on amylin aggregation and cytotoxicity of the secoiridoid oleuropein aglycon, the main phenolic component of extra virgin olive oil. We found that oleuropein, when present during the aggregation of amylin, consistently prevented its cytotoxicity to RIN-5F pancreatic beta-cells, as determined by the ...

2009-07-18

215

Le leucodistrofie: aspetti clinici e quadri con Tomografia Computerizzata e con Risonanza Magnetica  

International Nuclear Information System (INIS)

Leukodystrophies are inherited white matter diseases due to abnormalities occurring in myelin synthesis and/or maintenance. The most common types of these rare childhood conditions are represented by adrenoleukodystrophy, metachromatic leukodystrophy, Canavan's, Alexander's, Krabbe's, and Pelizaeus-Merzbacher's diseases. Most of them are lethal during childhood, with the exception of the adrenoleukodystrophy-adrenomyeloneuropathy complex, which sometimes, during its early phases, may be cured with a dietary therapy. The aims of this paper are: 1) the description of inheritance factors, pathogenesis, pathological and clinical findings of each of the most frequent childhood leukodystrophies; 2) the description of the most common patterns of these conditions on CT and MR imaging; 3) the evaluation of the diagnostic capabilities of these two imaging techniques and the comparison of their results. Finally, some of the therapies suggested for the mild forms of these ...

1991-01-01

216

Host resistance to rat cytomegalovirus (RCMV) and immune function in adult PVG rats fed herring from the contaminated Baltic Sea  

Energy Technology Data Exchange (ETDEWEB)

We carried out a feeding study in rats aimed at extending our aboservations of contaminant-induced immunosuppression in harbour seals. Two herring batches were freeze-dried, supplemented and fed to female adult PVG rats for a period of 4 1/2 months. Daily contaminant intakes of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalents (TEQ) were estimated to be 0.3 ng/kg body weight and 1.6 ng/kg in the Atlantic and Baltic groups, respectively. At the end of the feeding experiment, no contaminant-related changes in spleen CD{sub 4}{sup +}/CD{sub 8}{sup +} cellularity, natural killer cell activity, or mitogen-induced proliferative responses of thymus or spleen cells could be detected. However, total thymocyte numbers and thymus CD{sub 4}{sup +}/CD{sub 8}{sup +} ratios were reduced in the Baltic group. A novel model was established to assess the specific T-cell response to rat cytomegalovirus (RCMV). When applied to the feeding study, no differences between the Atlantic and Baltic ...

1996-08-01

217

Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function.  

Science.gov (United States)

Inhibition of the phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is an appealing method for decreasing the immunoresistance and augmenting T cell-mediated immunotherapy. A major impediment to this strategy is the impact of conventional PI3K/mTOR pathway inhibitors on T cell function. In particular, rapamycin, is a well-known immunosuppressant that can decrease the activity of the PI3K/mTOR pathway in tumor cells, but also has a profound inhibitory effect on T cells. Here we show that Honokiol, a natural dietary product isolated from an extract of seed cones from Magnolia grandiflora, can decrease PI3K/mTOR pathway-mediated immunoresistance of glioma, breast and prostate cancer cell lines, without affecting critical proinflammatory T cell functions. Specifically, we show that at doses sufficient to down-regulate levels of phospho-S6 and the negative immune regulator B7-H1 in tumor cells, Honokiol does not significantly impair T cell ...

218

Electron-optical microscopic study of incipient dental microdamage from experimental seed and bone crushing  

Energy Technology Data Exchange (ETDEWEB)

No living analogue exists for the hypothetical early hominid hard/tough-seed, coarse-root-eating, and bone-crushing masticatory adaptation. To investigate possible microdamage/microwear to dental enamel caused by such usage, puncture-crushing experiments were carried out on single human teeth, using an Instron compression apparatus on the following six test materials: Makapansgat Limeworks chert (e.g., taphonomy), fresh steer longbone, mongongo nuts, Grewia berries, Carob beans, and wild-onion bulbs. Pairs of extracted unworn third molars were utilized, with one tooth acting as the control. The teeth were mounted, ultrasonically cleaned, and two-stage replicas made with a vinyl polysiloxane elastomer and araldite epoxy resin. After Instron loading and materials failure (1.2-395.0 kg) the test items and the crowns were prepared for comparison with scanning electron microscopy and dispersive x-ray elemental analysis and mapping. The results revealed that although grit adhering to food ...

1982-03-01

219

Effect of lead exposure in children  

International Nuclear Information System (INIS)

Increasing prosperity and population-growth in many developing countries are resulting in accelerated growth in population of vehicles and vehicle-kilometers traveled. In Pakistan also, the number of vehicles has jumped from 0.8 million to about 4.0 million within 20 years, showing an overall increase of more than 400%. Accordingly, the consumption of petrol (motor spirit) has increased from 828,670 metric tons to 1,189,042 metric tons. The high content of lead in petrol is a serious issue, as the end- product is the release of lead into the environment. In Pakistan, prior to July 2001, lead-content in petrol was reported to be as high as 0.35-0.84 gram per liter. The reported lead-levels in air (micrograms/cubic centimeter) in different cities of Pakistan are: Karachi (1980-81) 0.13-0.24; Peshawar (1994-95) 0.21-0.79; Lahore (1993-94) 0.15-8.36 and (1999-2000) 0.89-7.85 and Rawalpindi (1999-2000) 0.71-10.00, indicating the very alarming increase and high levels of lead in the ambient ...

220

Comparison of Nutrient Content and Cost of Home-Packed Lunches to Reimbursable School Lunch Nutrient Standards and Prices  

Science.gov (United States)

Purpose: The purpose of this study was to compare nutrient content and cost of home-packed lunches to nutrient standards and prices for reimbursable school lunches. Methods: Researchers observed food and beverage contents of 333 home packed lunches at four north Texas elementary schools. Nutritionist Pro was used to analyze lunches for calories, total fat, saturated fat, protein, fiber, vitamin A, vitamin C, calcium, iron, fiber, and sodium content. These values were then compared to National School Lunch Program (NSLP) standards and other nutrient standards. Cost of each home-packed lunch was estimated based on food prices at three local supermarkets. A one-sample t-test (p = 0.05) was used to compare nutrient values of home packed lunches to National School Lunch Program (NSLP) standards. A paired t-test was used to compare cost of home packed lunches to each school's full price for a reimbursable school lunch. Results: Home packed lunches differed significantly from NSLP nutrient ...

2008-12-01

221

Resource Management plan for the Oak Ridge Reservation. Volume 28, Wetlands on the Oak Ridge Reservation  

Energy Technology Data Exchange (ETDEWEB)

A survey of wetlands on the Oak Ridge Reservation (ORR) was conducted in 1990. Wetlands occurring on ORR were identified using National Wetlands Inventory (NWI) maps and field surveys. More than 120 sites were visited and 90 wetlands were identified. Wetland types on ORR included emergent communities in shallow embayments on reservoirs, emergent and aquatic communities in ponds, forested wetland on low ground along major creeks, and wet meadows and marshes associated with streams and seeps. Vascular plant species occurring on sites visited were inventoried, and 57 species were added to the checklist of vascular plants on ORR. Three species listed as rare in Tennessee were discovered on ORR during the wetlands survey. The survey provided an intensive ground truth of the wetlands identified by NWI and offered an indication of wetlands that the NWI remote sensing techniques did not detect.

1991-12-01

222

Resource Management plan for the Oak Ridge Reservation  

Energy Technology Data Exchange (ETDEWEB)

A survey of wetlands on the Oak Ridge Reservation (ORR) was conducted in 1990. Wetlands occurring on ORR were identified using National Wetlands Inventory (NWI) maps and field surveys. More than 120 sites were visited and 90 wetlands were identified. Wetland types on ORR included emergent communities in shallow embayments on reservoirs, emergent and aquatic communities in ponds, forested wetland on low ground along major creeks, and wet meadows and marshes associated with streams and seeps. Vascular plant species occurring on sites visited were inventoried, and 57 species were added to the checklist of vascular plants on ORR. Three species listed as rare in Tennessee were discovered on ORR during the wetlands survey. The survey provided an intensive ground truth of the wetlands identified by NWI and offered an indication of wetlands that the NWI remote sensing techniques did not detect.

1991-12-01

223

Plan for addressing issues relating to oil shale plant siting  

Energy Technology Data Exchange (ETDEWEB)

The Western Research Institute plan for addressing oil shale plant siting methodology calls for identifying the available resources such as oil shale, water, topography and transportation, and human resources. Restrictions on development are addressed: land ownership, land use, water rights, environment, socioeconomics, culture, health and safety, and other institutional restrictions. Descriptions of the technologies for development of oil shale resources are included. The impacts of oil shale development on the environment, socioeconomic structure, water availability, and other conditions are discussed. Finally, the Western Research Institute plan proposes to integrate these topics to develop a flow chart for oil shale plant siting. Western Research Institute has (1) identified relative topics for shale oil plant siting, (2) surveyed both published and unpublished information, and (3) identified data gaps and research ...

1987-09-01

224

Identification of optimum sites for power system stabilizer applications  

Energy Technology Data Exchange (ETDEWEB)

Many existing methods of identifying the optimum sites for installing power system stabilizers (PSSs) in multi-machine systems are restricted to the sequential PSS application, which considers the enhancement of damping of just one critical electromechanical mode at a time; the eigenstructure analysis of the open-loop system, which does not take the control matrix (i.e., the B matrix in the linearized model x = Ax + Bu for power systems) into consideration. This paper presents a method of identifying the optimum sites for installing power system stabilizers. The advantages of this method are: it can identify the optimum sites for installing PSSs so that several electrochemical modes are damped out simultaneously; it takes both the eigenstructure of the open-loop system and the control matrix into consideration.

1990-11-01

225

Environmental analysis of endocrine disrupting effects from hydrocarbon contaminants in the ecosystem. 1997 annual progress report  

Energy Technology Data Exchange (ETDEWEB)

'The overall objective of the basic research grant is to characterize the potential of common hydrocarbon contaminants in ecosystems to act as endocrine disruptors. The three major lines of research include (1) a biotechnology based screening system to identify potential hormone mimics and antagonists; (2) an animal screening system to identify biomarkers of endocrine effects. and (3) a literature review to identify compounds at a variety of DOE sites that need to be examined for endocrine disrupting effects. By relating results obtained from this research project to contamination problems at various DOE sites. CBR will provide data and information on endocrine disrupting contaminants to DOE for consideration in risk analyses for determining clean-up levels and priorities needed at the sites.'

1997-01-01

226

DNA barcoding as a tool for species identification in three forensic wildlife cases in South Africa  

British Library Electronic Table of Contents (United Kingdom)

Poaching of wildlife animals for subsistence and commercial purposes has lead to population declines in Africa. In forensic cases, a need exists to identify the species of origin of carcasses, meat or blood. In the study presented here, the mitochondrial COI gene was sequenced to determine the species of unknown samples in three suspect South African forensic wildlife cases. In two cases the unknown samples were identified as originating from domestic cattle (Bos taurus) and in the third case the sample was identified as common reedbuck (Redunca arundinum). This is the first report of the COI sequence of common reedbuck. The study highlights the need for accurate wildlife reference material from each country in order to convict wildlife cases.

2011-01-01

227

Assessment of coal gasification/hot gas cleanup based advanced gas turbine systems: Greenfield assessment. Final report  

Energy Technology Data Exchange (ETDEWEB)

Both the KRW fluidized-bed gasifier and the transport gasifier case studies were used for this assessment. The transport technology is a high-velocity circulating fluidized-bed reactor currently under development by The M.W. Kellogg Company. In the earlier assessment, seven design concepts or cases were identified; a process design was developed; major equipment items were identified; estimates of capital cost, operation and maintenance cost, and cost of electricity were developed; reliability was predicted; and development issues were identified for six studies. Three of the most probable cases were further evaluated for a Greenfield assessment in this report to adequately determine all costs independent of facilities at Plant Wansley.

1991-12-01

228

Assessment of coal gasification/hot gas cleanup based advanced gas turbine systems: Greenfield assessment  

Energy Technology Data Exchange (ETDEWEB)

Both the KRW fluidized-bed gasifier and the transport gasifier case studies were used for this assessment. The transport technology is a high-velocity circulating fluidized-bed reactor currently under development by The M.W. Kellogg Company. In the earlier assessment, seven design concepts or cases were identified; a process design was developed; major equipment items were identified; estimates of capital cost, operation and maintenance cost, and cost of electricity were developed; reliability was predicted; and development issues were identified for six studies. Three of the most probable cases were further evaluated for a Greenfield assessment in this report to adequately determine all costs independent of facilities at Plant Wansley.

1991-12-01

229

Application of remote sensing to identify coalfires in the Raniganj Coalbelt, India  

British Library Electronic Table of Contents (United Kingdom)

Raniganj and Jharia regions together have been for long the single largest coal supplier in India, now contributing about a quarter of the total output in the country. Numerous reasons such as improper mining techniques and policy, as well as unauthorized mining caused surface and subsurface coalfires in these areas. These coalfires burn millions of tonnes of valuable coal resources, creating severe environmental problems and posing enormous operational difficulties of mining. After first use of remote sensing as a tool to identify coalfires in 1960s, with the time, the efficiency of remote sensing to identify and monitoring coalfires has been well established by several researchers. With the knowledge of local geological setting and density sliced surface temperature image the spatial dis...

2006-01-01

230

Analysis of organic acids in the pyrohydrolysis distillate of (U,Pu) mixed carbide fuel by ion chromatography  

International Nuclear Information System (INIS)

The study reports the identification of different organic acids that are formed during the pyrohydrolysis of mixed carbide of uranium and plutonium using ion chromatography (IC). The identification of organic acids present in the pyrohydrolysis distillate is required to carry out interference free analysis of Cl and F. The study describes three stage isocratic separations with NaOH eluents having concentrations 2 mM, 10 mM and 50 mM respectively in order to separate and identify both aliphatic and aromatic acids. The present investigation identified formic, acetic, propionic, butyric, tartaric and oxalic acids in the distillate, however, aromatic acids could not be identified. (author)

2011-02-22

231

An evaluation of the UK skills base for toxicologists and ecotoxicologists, with focus on current and future requirements, particularly with regard to the skills required for hazard assessment of chemical substances including nanomaterials  

Environmental Research Database

Objectives1. To establish the present capacity and capability across all the sectors within the UK for - a) Undertaking research in the areas of toxicology and ecotoxicology and environmental hazard and risk assessment work on chemical subtances including emerging containments (e.g. enginerred nanomaterials); and b) Applying these skills in the policy and regulatory context. 2) The range of chemicals involved should include pharmaceutical and medical products, crop protection agents, biocides, vet [continued...]DescriptionThe aim of this project is to identify the current status of the scientific community, areas of expertise, and identify the gaps in skills, knowledge or recruitment. The project will use a questionnaire approach to obtain this information for all sectors of the business community. The analysis will identify the gaps in provision, and areas where investment is needed in future training and/or recruitment.

2009-01-15

232

misty somites, a maternal effect gene identified by transposon-mediated insertional mutagenesis in zebrafish that is essential for the somite boundary maintenance  

UK PubMed Central (United Kingdom)

Somite boundary formation is crucial for segmentation of vertebrate somites and vertebrae and skeletal muscle morphogenesis. Previously, we developed a Tol2 transposon-mediated...Full Text Available

2008-04-15

233

aHUS caused by complement dysregulation: new therapies on the horizon  

UK PubMed Central (United Kingdom)

Atypical hemolytic uremic syndrome (aHUS) is a heterogeneous disease that is caused by defective complement regulation in over 50% of cases. Mutations have been identified in genes encoding both complement...Full Text Available

2011-01-01

234

Workshop to identify critical windows of exposure for children's health: neurobehavioral work group summary.  

UK PubMed Central (United Kingdom)

This paper summarizes the deliberations of a work group charged with addressing specific questions relevant to risk estimation in developmental neurotoxicology. We focused on eight questions. a) Does...Full Text Available

2000-06-01

235

Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection  

UK PubMed Central (United Kingdom)

The protozoan parasite Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical infection that affects millions of people in the Americas. Current chemotherapy...Full Text Available

236

Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans  

UK PubMed Central (United Kingdom)

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers...Full Text Available

2011-04-01

237

Validation of the treatment identification strategy of the HEDIS addiction quality measures: concordance with medical record review  

UK PubMed Central (United Kingdom)

BackgroundStrategies to accurately identify the occurrence of specific health care events in administrative data is central to many quality improvement and research efforts. Many...Full Text Available

238

Using microarrays to identify positional candidate genes for QTL: the case study of ACTH response in pigs  

UK PubMed Central (United Kingdom)

BackgroundMicroarray studies can supplement QTL studies by suggesting potential candidate genes in the QTL regions, which by themselves are too large to provide a limited selection...Full Text Available

239

Using Regulatory and Epistatic Networks to Extend the Findings of a Genome Scan: Identifying the Gene Drivers of Pigmentation in Merino Sheep  

UK PubMed Central (United Kingdom)

Extending genome wide association analysis by the inclusion of gene expression data may assist in the dissection of complex traits. We examined piebald, a pigmentation phenotype in both human and Merino...Full Text Available

240

Use of solid state nuclear track detectors for radon concentration measurements indoors  

International Nuclear Information System (INIS)

An indoor radioactive survey is being conducted in an Italian district. Preliminary results identified a zone with significant radioactive levels, in which a new specific survey has been planned. In this paper attention is dedicated mainly to radon measurement technique and results.

241

Uptake of injected 125I-ricin by rat liver in vivo. Subcellular distribution and characterization of the internalized ligand.  

UK PubMed Central (United Kingdom)

Subcellular-fractionation techniques were used to characterize the endocytic pathway followed by ricin in rat liver in vivo and tentatively identify the site(s) at which the ricin interchain disulphide...Full Text Available

1992-05-15

242

Tumor-derived extracellular mutations of PTPRT/PTP? are deficient in cell adhesion  

UK PubMed Central (United Kingdom)

Receptor protein tyrosine phosphatase T (PTPRT/PTPρ) is frequently mutated in human cancers including colon, lung, gastric and skin cancers. More than half of the identified tumor-derived...Full Text Available

2008-07-01

243

Treatment with Selective Serotonin Reuptake Inhibitors and Mirtapazine Results in Differential Brain Activation by Visual Erotic Stimuli in Patients with Major Depressive Disorder  

UK PubMed Central (United Kingdom)

ObjectiveThe objective of this study was to identify patterns of brain activation elicited by erotic visual stimuli in patients treated with either Selective Serotonin Reuptake Inhibitors...Full Text Available

2009-06-01

244

Trauma service cost: the real story.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective was to define and characterize the costs associated with trauma care at a level I trauma center. Once the costs were identified, attending physician-led teams were designed...Full Text Available

1998-05-01

245

The feasibility of using pattern recognition software to measure the influence of computer use on the consultation  

UK PubMed Central (United Kingdom)

BackgroundA key feature of a good general practice consultation is that it is patient-centred. A number of verbal and non-verbal behaviours have been identified as important to establish...Full Text Available

246

The Relationship between Leishmaniasis and AIDS: the Second 10 Years  

UK PubMed Central (United Kingdom)

Summary: To date, most Leishmania and human immunodeficiency virus (HIV) coinfection cases reported to WHO come from Southern Europe. Up to the year 2001, nearly 2,000 cases of coinfection were identified,...Full Text Available

2008-04-01

247

The Mitochondrial Isovaleryl-Coenzyme A Dehydrogenase of Arabidopsis Oxidizes Intermediates of Leucine and Valine Catabolism1  

UK PubMed Central (United Kingdom)

We recently identified a cDNA encoding a putative isovaleryl-coenzyme A (CoA) dehydrogenase in Arabidopsis (AtIVD). In animals, this homotetrameric enzyme is located in mitochondria and catalyzes the...Full Text Available

2001-06-01

248

The Challenge of Basic Education for All.  

Science.gov (United States)

Clarifies the concept of universal basic education. Highlights the need for performance criteria and ways to measure literacy attainment. Identifies issues related to improving primary education, seeing adult literacy as its necessary complement. Underscores the substantial resources required to achieve universal basic education. (CH)

1988-12-01

249

The Arabidopsis ref2 Mutant Is Defective in the Gene Encoding CYP83A1 and Shows Both Phenylpropanoid and Glucosinolate Phenotypes  

UK PubMed Central (United Kingdom)

The Arabidopsis ref2 mutant was identified in a screen for plants having altered fluorescence under UV light. Characterization of the ref2 mutants showed that they...Full Text Available

2003-01-01

250

The Anopheles gambiae glutathione transferase supergene family: annotation, phylogeny and expression profiles  

UK PubMed Central (United Kingdom)

BackgroundTwenty-eight genes putatively encoding cytosolic glutathione transferases have been identified in the Anopheles gambiae genome. We manually annotated these...Full Text Available

251

Terminal-differential algorithm for identification of local non homogeneity in article  

International Nuclear Information System (INIS)

Terminal-differential algorithm for identification of local nonhomogeneities in items under control is developed on the basis of measurements of X-ray or gamma-radiation weakening. The algorithm may be applied by developing radiation schemes of nondestructive control, identifying inadmissible inclusions in the object under study

252

Tachyons and the instability of physical systems  

International Nuclear Information System (INIS)

The problem on the ratio between the instability of physical systems and tachyons is discussed. It is shown that the tachyons participation in the real physical process of the system rearranging does not contradict any principles. It is noted that the tachyons constitute the most significant element of the systems, identifying the instability relative to the phase transition into the stable state.

253

Syk Tyrosine Kinase Acts as a Pancreatic Adenocarcinoma Tumor Suppressor by Regulating Cellular Growth and Invasion  

UK PubMed Central (United Kingdom)

We have identified the nonreceptor tyrosine kinase syk as a marker of differentiation/tumor suppressor in pancreatic ductal adenocarcinoma (PDAC). Syk expression is lost in poorly differentiated PDAC...Full Text Available

2009-12-01

254

Swift Science Center - HEASARC - NASA  

Science.gov (United States)

Apr 20, 2009 ... "YY" is the 2-digit filter identifier .... In our example you can see a point- like optical/UV source in each of the filters at the ... The "sigma" paramter gives the detection threshold in terms of Gaussian sigma. ...

255

Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection  

UK PubMed Central (United Kingdom)

BackgroundXenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study,...Full Text Available

256

Survival of HIV-Infected Adolescents on Antiretroviral Therapy in Uganda: Findings from a Nationally Representative Cohort in Uganda  

UK PubMed Central (United Kingdom)

BackgroundAdolescents have been identified as a high-risk group for poor adherence to and defaulting from combination antiretroviral therapy (cART) care. However, data on outcomes...Full Text Available

257

Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid  

UK PubMed Central (United Kingdom)

Surfactant protein A (SP-A), first identified as a component of the lung surfactant system, is now recognized to be an important contributor to host defence mechanisms. SP-A can facilitate phagocytosis...Full Text Available

2004-01-01

258

Sugarcane pests and their management  

Science.gov (United States)

This book chapter discusses sugarcane culture and history, describes arthropod biologies and injury, and identifies sugarcane pest management factors to consider for people interested in commercial sugarcane production. Arthropod groups include 10 orders and 40 families. Sugarcane pest management ...

259

Study on the transient piping vibration of power plant. Secondary piping system of Wolsung 1 unit.  

Science.gov (United States)

In order to maintain a safe operation and availability of generating facilities, qualitative and quantitative assessment of piping vibration was performed vibration sources and damages of piping support was identified on the second piping system of Wolsun...

1996-01-01

260

Statistical methods for the blood beryllium lymphocyte proliferation test.  

UK PubMed Central (United Kingdom)

The blood beryllium lymphocyte proliferation test (BeLPT) is a modification of the standard lymphocyte proliferation test that is used to identify persons who may have chronic beryllium disease. A major...Full Text Available

1996-10-01

261

Some design considerations for solar-powered aircraft  

Energy Technology Data Exchange (ETDEWEB)

Performance and operating characteristics are presented for a solar powered aircraft intended to remain aloft for long periods. The critical technologies which limit the performance are identified. By using the techniques presented, the effects of variation in the system parameters are studied. Practical design consideration are discussed.

1980-06-01

262

Sequential Molecular and Cellular Events during Neoplastic Progression: A Mouse Syngeneic Ovarian Cancer Model1  

UK PubMed Central (United Kingdom)

AbstractStudies performed to identify early events of ovarian cancer and to establish molecular markers to support early detection and development of chemopreventive regimens have been...Full Text Available

2005-10-01

263

Self-Medication: Initial Treatments Used by Patients Seen in an Ophthalmologic Emergency Room  

UK PubMed Central (United Kingdom)

OJECTIVEThis study seeks to identify practices of self-medication in the treatment of ocular emergencies. We examine patients’ use of both homemade preparations and manufactured...Full Text Available

2009-08-01

264

Selection of Inhibitor-Resistant Viral Potassium Channels Identifies a Selectivity Filter Site that Affects Barium and Amantadine Block  

UK PubMed Central (United Kingdom)

BackgroundUnderstanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function...Full Text Available

265

Retrospective identification and characterization of mild cognitive impairment from a prospective population cohort  

UK PubMed Central (United Kingdom)

ObjectivesMild Cognitive Impairment (MCI) case-finding criteria have low specificity in general population studies. The present study retrospectively identifies cases...Full Text Available

2010-08-01

266

Retention, Learning by Doing, and Performance in Emergency Medical Services  

UK PubMed Central (United Kingdom)

ObjectivesTo examine the strength of the volume–outcome relationship among paramedics, a group of providers that has not been previously studied in this context. By identifying...Full Text Available

2009-06-01

267

Repeated tumor oximetry to identify therapeutic window during metronomic cyclophosphamide treatment of 9L gliomas  

UK PubMed Central (United Kingdom)

Malignant gliomas are aggressive and angiogenic tumors with high VEGF content. Consequently, approaches such as metronomic chemotherapy, which have an antiangiogenic effect, are being investigated....Full Text Available

2011-07-01

268

Renewable energy and the ODA energy efficient strategy  

Energy Technology Data Exchange (ETDEWEB)

The energy strategy of the UK Overseas Development Administration is outlined with specific emphasis on energy efficiency and renewable energies. Based on 29 case studies concerning projects and programmes in both developed and developing countries, critical success factors for renewable energy projects are identified. UK)

1995-12-31

269

Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice  

UK PubMed Central (United Kingdom)

Sensory neurons in aging mammals undergo changes in anatomy, physiology and gene expression that correlate with reduced sensory perception. In this study we compared young and aged mice to identify...Full Text Available

2006-06-01

270

Reduced Accumulation of ABA during Water Stress in a Molybdenum Cofactor Mutant of Barley 1  

UK PubMed Central (United Kingdom)

A barley (Hordeum vulgare L.) mutant (Az34) has been identified with low basal levels of abscisic acid (ABA) and with reduced capacity for producing ABA in response to water stress....Full Text Available

1989-06-01

271

Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545  

UK PubMed Central (United Kingdom)

The aspirin esterase activity of human plasma is due to butyrylcholinesterase and albumin. Our goal was to identify the amino acid residues involved in the aspirin esterase activity of albumin....Full Text Available

2010-03-01

272

Radiographic monitoring of incidental abdominal aortic aneurysms: a retrospective population-based cohort study  

UK PubMed Central (United Kingdom)

BackgroundAn abdominal aortic aneurysm (AAA) that is identified when the abdomen is imaged for some other reason is known as an incidental AAA. No population-based studies have...Full Text Available

273

Queensland resources of black coal, December 1988  

Energy Technology Data Exchange (ETDEWEB)

This assessment of Queensland's resources of black coal has been prepared by the Coal and Oil Shale Resources Assessment and Development Subprogram, Queensland Department of Mines, in accordance with the 'Code for Reporting of Identified Coal Resources and Reserves'.

1989-01-01

274

Quality assessment of reporting of randomization, allocation concealment, and blinding in traditional chinese medicine RCTs: A review of 3159 RCTs identified from 260 systematic reviews  

UK PubMed Central (United Kingdom)

BackgroundRandomized controlled trials (RCTs) which are of poor quality tend to exaggerate the effect estimate and lead to wrong or misleading conclusions. The aim of this study...Full Text Available

275

Psychology and health: contributions of psychology to the improvement of health and health care  

UK PubMed Central (United Kingdom)

Psychology as both a science and a profession has been closely identified with other disciplines in the broad field of health since the turn of the present century. Recent advances in health care have...Full Text Available

1987-01-01

276

Proteomic approach with LCMS-IT-TOF identified an increase of Rab33B after transient focal cerebral ischemia in mice  

UK PubMed Central (United Kingdom)

BackgroundSeveral proteins are known to be markedly expressed in the brain during cerebral ischemia; however, the changes in protein profiles within the ischemic brain after an ischemic...Full Text Available

277

Proteome of human colon cancer stem cells: A comparative analysis  

UK PubMed Central (United Kingdom)

AIM: To isolate and identify the biological characteristics of human colon cancer stem cells (SW1116 cells) and further study their proteome.METHODS: SW1116 cells were isolated and cultured with...Full Text Available

2011-03-14

278

Prosthesis use in persons with lower- and upper-limb amputation  

UK PubMed Central (United Kingdom)

This study identified clinical (e.g., etiology) and demographic factors related to prosthesis use in persons with upper- and lower-limb amputation (ULA and LLA, respectively) and the effect...Full Text Available

2008-01-01

279

Proline Betaine Accumulation and Metabolism in Alfalfa Plants under Sodium Chloride Stress. Exploring Its Compartmentalization in Nodules1  

UK PubMed Central (United Kingdom)

The osmoprotectant Pro betaine is the main betaine identified in alfalfa (Medicago sativa). We have investigated the long-term responses of nodulated alfalfa plants to salt stress,...Full Text Available

2004-07-01

280

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety  

UK PubMed Central (United Kingdom)

Preterm birth is the leading cause of neonatal mortality and morbidity and long-term disability of non-anomalous infants. Previous studies have identified a prior early spontaneous preterm birth as...Full Text Available

2009-01-01

281

Predictors of disability in a longitudinal sample of patients with rheumatoid arthritis.  

UK PubMed Central (United Kingdom)

Information from the Health Assessment Questionnaire (HAQ) is used to identify which variables measured in 1981 successfully predict the severity of disease in 1989 and the eight year change in severity...Full Text Available

1992-05-01

282

Predictors for presence and abundance of small mammals in households of villages endemic for commensal rodent plague in Yunnan Province, China  

UK PubMed Central (United Kingdom)

BackgroundNinety-one rodent plague epidemics have occurred in Lianghe county, Yunnan Province, China, between 1990 and 2006. This study aimed to identify predictors for the presence...Full Text Available

283

Predicting outcome of rethoracotomy for suspected pericardial tamponade following cardio-thoracic surgery in the intensive care unit  

UK PubMed Central (United Kingdom)

ObjectivesPericardial tamponade after cardiac surgery is difficult to diagnose, thereby rendering timing of rethoracotomy hard. We aimed at identifying factors predicting the outcome...Full Text Available

284

Potentially Inappropriate Prescribing of Benzodiazepines for Older Adults and Risk of Falls During a Hospital Stay: A Descriptive Study  

UK PubMed Central (United Kingdom)

Background:Falls have been identified as a potential adverse event associated with the administration of psychotropic medications to older patients.Objective:The...Full Text Available

2009-07-01

285

Polyantigenic Interferon-? Responses Are Associated with Protection from TB among HIV-Infected Adults with Childhood BCG Immunization  

UK PubMed Central (United Kingdom)

BackgroundSurrogate immunologic markers for natural and vaccine-mediated protection against tuberculosis (TB) have not been identified.MethodsHIV-infected...Full Text Available

286

Phosphorylated PmrA Interacts with the Promoter Region of ugd in Salmonella enterica Serovar Typhimurium  

UK PubMed Central (United Kingdom)

The Salmonella PmrA-PmrB system controls the expression of genes necessary for polymyxin B resistance. Four loci were previously identified as part of the regulon, and interaction of...Full Text Available

2000-07-01

287

Patient-Care Practices Associated With an Increased Prevalence Of Hepatitis C Virus Infection among Chronic Hemodialysis Patients  

UK PubMed Central (United Kingdom)

ObjectiveTo identify patient-care practices related to an increased prevalence of hepatitis C virus (HCV) infection among chronic hemodialysis patients.Full Text Available

2011-05-01

288

Past, present, and future of mutagens in cooked foods.  

UK PubMed Central (United Kingdom)

Mutation assay with Salmonella typhimurium enabled us to detect various types of mutagens in cooked foods. A series of mutagenic heterocyclic amines has been isolated and identified in broiled fish...Full Text Available

1986-08-01

289

Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.  

UK PubMed Central (United Kingdom)

In an earlier report, we used differential cloning to identify genes that might be critical in controlling arterial neointima formation (Giachelli, C., N. Bae, D. Lombardi, M. Majesky, and S. Schwartz....Full Text Available

1993-10-01

290

Online quasi-continuous measurement of organic acids in the atmosphere  

Energy Technology Data Exchange (ETDEWEB)

The concentration of some organic acids in the atmosphere was determined using a wet effluent diffusion denuder-aerosol collector coupled with Ion Chromatography. Three organic acids and four inorganic anions were identified and quantified in the air sample, taken from the backyard of PSI. (author)

2002-03-01

291

Oil palm (Elaeis guineensis Jacq.) tissue culture ESTs: Identifying genes associated with callogenesis and embryogenesis  

UK PubMed Central (United Kingdom)

BackgroundOil palm (Elaeis guineensis Jacq.) is one of the most important oil bearing crops in the world. However, genetic improvement of oil palm through conventional...Full Text Available

292

Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression  

UK PubMed Central (United Kingdom)

Noncoding RNAs play important roles in various aspects of gene regulation. We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGCs), a subnuclear domain...Full Text Available

2010-12-01

293

Novel high-throughput screening system for identifying STAT3-SH2 antagonists  

International Nuclear Information System (INIS)

Constitutive activation of the oncogenic transcription factor STAT3 frequently occurs in various human malignancies. STAT3 activation involves dimerization via intermolecular pTyr-SH2 interaction. Thus, antagonizing this interaction is a feasible approach to inhibit STAT3 activation for cancer therapy. In order to identify selective STAT3 inhibitors, we developed a biochemical HTS system based on AlphaScreen technology, which measures the abilities of test compounds to antagonize pTyr-SH2 interactions. We screened our chemical libraries using this system and identified 5,15-diphenylporphyrin (5,15-DPP) as a selective STAT3-SH2 antagonist. Selective inhibition of STAT3 nuclear translocation and DNA biding activity was observed in cells treated with 5,15-DPP. IL-6-dependent dimerization of STAT3, c-myc promoter binding and c-myc protein expression were all suppressed by 5,15-DPP, whereas no decrement in either expression or phosphorylation level ...

2009-03-13

294

Nitric Oxide Emissions from Soybean Leaves during in Vivo Nitrate Reductase Assays 1  

UK PubMed Central (United Kingdom)

Recent work identified acetaldehyde oxime as the predominant product purged by inert gases from anaerobic in vivo nitrate reductase (NR) assays of soybean (Glycine max...Full Text Available

1987-09-01

295

Mutation analysis of 272 Spanish families affected by autosomal recessive retinitis pigmentosa using a genotyping microarray  

UK PubMed Central (United Kingdom)

PurposeRetinitis pigmentosa (RP) is a genetically heterogeneous disorder characterized by progressive loss of vision. The aim of this study was to identify the causative mutations...Full Text Available

296

Mutation Spectrum of EYS in Spanish Patients with Autosomal Recessive Retinitis Pigmentosa  

UK PubMed Central (United Kingdom)

Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal dystrophies characterised ultimately by the loss of photoreceptor cells. We have recently identified a new gene (EYS) encoding...Full Text Available

2010-11-01

297

Multicenter Case-Control Study on Restless Legs Syndrome in Multiple Sclerosis: the REMS Study  

UK PubMed Central (United Kingdom)

Study objectives:To verify the existence of a symptomatic form of restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and to identify possible associated risk factors.Design:Prospective,...Full Text Available

2008-07-01

298

Morphology of inhibitory and excitatory interneurons in superficial laminae of the rat dorsal horn  

UK PubMed Central (United Kingdom)

If we are to stand any chance of understanding the circuitry of the superficial dorsal horn, it is imperative that we can identify which classes of interneuron are excitatory and which are inhibitory....Full Text Available

2007-10-15

299

Monitoring the Simultaneous Presentation of Spatialized Speech Signals in a Virtual Acoustic Environment.  

Science.gov (United States)

The effect of spatial auditory information on a listener's ability to detect, identify, and monitor multiple simultaneous speech signals was evaluated using virtual audio technology. Factorial combinations of three variables - the number of localized spee...

1998-01-01

300

Monitoring of NK-Cell Immunotherapy using non-invasive Imaging Modalities  

UK PubMed Central (United Kingdom)

Cancer immunotherapies can be guided by cellular imaging techniques, which can identify the presence or absence of immune-cell accumulation in the tumor tissue in-vivo and in real time. This...Full Text Available

2010-08-01

301

Molecular cloning and nucleotide sequence of the beta-lytic protease gene from Achromobacter lyticus.  

UK PubMed Central (United Kingdom)

Two bacteriolytic enzymes secreted by Achromobacter lyticus M497-1 were purified and identified as being very similar (considering their amino acid composition and N-terminal sequence) to alpha- and...Full Text Available

1990-11-01

302

Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans  

UK PubMed Central (United Kingdom)

The fungus Cryptococcus neoformans is a major cause of morbidity and mortality in patients with impaired CD4+ T cell function, particularly those with AIDS. To identify...Full Text Available

2001-08-28

303

Misclassification of Patients with Spinocerebellar Ataxia as Having Psychogenic Postural Instability Based on Computerized Dynamic Posturography  

UK PubMed Central (United Kingdom)

Specific criteria have been developed based on computerized dynamic posturography (CDP) to assist clinicians in identifying patients with psychogenic balance problems (Cyr and Cevette, Full Text Available

304

Milk fever and alert downer cows: Does hypophosphatemia affect the treatment response?  

UK PubMed Central (United Kingdom)

The purpose of this prospective cohort study was to identify factors that place a dairy cow with uncomplicated milk fever (MF) at significant risk of becoming an alert downer cow (ADC) and to verify...Full Text Available

2007-05-01

305

Microsoft Word - ~4679716.doc  

Wastenet

UNEP will provide in the first CPR quarterly report of 2011 the financial statements for 2010. ...for assessing and rating programme performance UNEP to work with the CPR to identify better ways of streamlining reporting requirements ...in 2011 to achieve the ratios requested by the CPR dependent on receipt of contributions originally planned for the

306

Measurement of Sexual Functioning After Spinal Cord Injury: Preferred Instruments  

UK PubMed Central (United Kingdom)

Background/Objective:To determine the utility of certain instruments to assess sexuality and fertility after SCI, an expert panel identified key areas to study and evaluated...Full Text Available

2009-06-01

307

Mapping neuropeptide expression by mass spectrometry in single dissected identified neurons from the dorsal ganglion of the nematode Ascaris suum  

UK PubMed Central (United Kingdom)

We have developed a method for dissecting single neurons from the nematode Ascaris suum, in order to determine their peptide content by mass spectrometry (MS). In this paper,...Full Text Available

2010-07-21

308

Manganese  

Science.gov (United States)

Sources of manganese are identified. Uptake and distribution of manganese in plants and man are discussed, and the role of manganese in metabolism is described. The epidemiology of manganese toxicity is outlined, permissible air concentrations are listed, and the symptoms of manganese toxicity and deficiency are described. 555 references, 32 tables.

1973-01-01

309

MFR, a Putative Receptor Mediating the Fusion of Macrophages  

UK PubMed Central (United Kingdom)

We had previously identified a macrophage surface protein whose expression is highly induced, transient, and specific, as it is restricted to actively fusing macrophages in vitro and in vivo. This protein...Full Text Available

1998-11-01

310

Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage Fc?RI, Fc?RIII, and Fc?RIV  

UK PubMed Central (United Kingdom)

Despite the demonstrated clinical efficacy of CD20 monoclonal antibody (mAb) for lymphoma therapy, the in vivo mechanisms of tumor depletion remain controversial and variable. To identify the molecular...Full Text Available

2008-08-15

311

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies  

UK PubMed Central (United Kingdom)

Recently, genome-wide association studies (GWAS) have linked the human LIN28B locus to height and timing of menarche [1-Full Text Available

2010-07-01

312

Light-Dependent Regulation of Cyanobacterial Phytochrome Expression  

UK PubMed Central (United Kingdom)

A histidine kinase protein (Cph1) with sequence homology and spectral characteristics very similar to those of the plant phytochrome has been recently identified in the cyanobacterium Synechocystis...Full Text Available

2000-01-01

313

Lameness, Activity Time-Budgets, and Estrus Expression in Dairy Cattle  

UK PubMed Central (United Kingdom)

The aim of the present study was to identify specific behavioral patterns that contribute to diminished estrus expression in lame cows. Behavioral scan and focal sampling were used to examine...Full Text Available

2008-12-01

314

Laboratory Evaluation of Base Materials for Neutralization of the Contaminated Aquifer at the F-Area Seepage Basins  

Energy Technology Data Exchange (ETDEWEB)

Laboratory studies were performed to support field-testing of base injection into the F-Area Seepage Basins groundwater. The general purpose of these experiments is to provide information to guide the test of base injection and to identify potential adverse effects.

2001-09-11

315

Isolation of caprine arthritis encephalitis virus from goats in Mexico.  

UK PubMed Central (United Kingdom)

A lentivirus was isolated from 2 goats in Mexico that were seropositive to caprine arthritis encephalitis virus (CAEV) by the agar gel immunodiffusion (AGID) test. The lentivirus was identified as CAEV...Full Text Available

1999-07-01

316

Isolation and identification of a cobamide coenzyme from the tapeworm Spirometra mansonoides.  

Science.gov (United States)

A light-sensitive vitamin B12 derivative has been extracted from the adult cestode, Spirometra mansonoides. This corrinoid was identified as the cobamide coenzyme, adenosylcobalamin, by its chromatographic, chemical, and spectral properties. PMID:1003284

1976-12-01

317

In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression  

UK PubMed Central (United Kingdom)

Mouse models have dramatically improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic...Full Text Available

2009-10-01

318

Improving Knowledge and Attitudes towards Depression: a controlled trial among Chinese medical students  

UK PubMed Central (United Kingdom)

BackgroundEstablishing an evidence-based method of improving knowledge and attitudes concerning depression has been identified as a priority in Chinese medical education. The purpose...Full Text Available

319

Immunoradiometric measurement of the factor VIII procoagulant antigen.  

UK PubMed Central (United Kingdom)

A fluid-phase immunoradiometric assay has been developed which identifies an antigen on the Factor VIII (antihemophilic factor) procoagulant protein. This sensitive and quantitative assay is not influenced...Full Text Available

1978-11-01

320

Identifying related L1 retrotransposons by analyzing 3' transduced sequences  

UK PubMed Central (United Kingdom)

BackgroundA large fraction of the human genome is attributable to L1 retrotransposon sequences. Not only do L1s themselves make up a significant portion of the genome, but L1-encoded...Full Text Available

2003-01-01

321

Identifying barriers to Papanicolaou smear screening in Korean women: Korean National Health and Nutrition Examination Survey 2005  

UK PubMed Central (United Kingdom)

ObjectiveThis study was conducted to provide a nationwide analysis on barriers to cervical cancer screening in Korea.MethodsData used for this study...Full Text Available

2010-06-01

322

Identifying and validating biomarkers for Alzheimer's disease  

UK PubMed Central (United Kingdom)

The identification and validation of biomarkers for diagnosing Alzheimer's disease (AD) and other forms of dementia are increasingly important. To date, ELISA measurement of β-amyloid(1–42),...Full Text Available

2011-01-01

323

Identification of cell cycle-related regulatory motifs using a kernel canonical correlation analysis  

UK PubMed Central (United Kingdom)

BackgroundGene regulation is a key mechanism in higher eukaryotic cellular processes. One of the major challenges in gene regulation studies is to identify regulators affecting the...Full Text Available

324

Identification of a stem cell candidate in the normal human prostate gland  

UK PubMed Central (United Kingdom)

Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+...Full Text Available

2005-03-01

325

Identification of a Copper-Responsive Two-Component System on the Chromosome of Escherichia coli K-12  

UK PubMed Central (United Kingdom)

Using a genetic screen we have identified two chromosomal genes, cusRS (ylcA ybcZ), from Escherichia coli K-12 that encode a two-component, signal...Full Text Available

2000-10-01

326

Identification of CTX-M-14 Extended-Spectrum ?-Lactamase in Clinical Isolates of Shigella sonnei, Escherichia coli, and Klebsiella pneumoniae in Korea  

UK PubMed Central (United Kingdom)

CTX-M-14 β-lactamase was identified in a stool isolate of Shigella sonnei and in blood isolates of Escherichia coli (one isolate) and Klebsiella pneumoniae...Full Text Available

2001-10-01

327

Identification and mobilization by cointegrate formation of a nodulation plasmid in Rhizobium trifolii.  

UK PubMed Central (United Kingdom)

A nodulation plasmid, pRtr-514a, of molecular size 180 megadaltons (Mdal) was identified in Rhizobium trifolii strain NZP514. This plasmid was absent in both spontaneous and heat-cured Nod- derivatives...Full Text Available

1982-07-01

328

Identification and Characterization of CPS1 as a Hyaluronic Acid Synthase Contributing to the Pathogenesis of Cryptococcus neoformans Infection?  

UK PubMed Central (United Kingdom)

Cryptococcus neoformans is a pathogenic yeast that often causes devastating meningoencephalitis in immunocompromised individuals. We have previously identified the C. neoformans...Full Text Available

2007-08-01

329

High-Risk Populations Identified in Childhood Cancer Survivor Study Investigations: Implications for Risk-Based Surveillance  

UK PubMed Central (United Kingdom)

Childhood cancer survivors often experience complications related to cancer and its treatment that may adversely affect quality of life and increase the risk of premature death. The purpose of this...Full Text Available

2009-05-10

330

High affinity of lead for fetal haemoglobin.  

UK PubMed Central (United Kingdom)

In-vitro experiments using 203Pb were performed to identify lead-binding components in human haemoglobin. Sephadex A-50 ion-exchange chromatography of haemolysate showed that different types of haemoglobin...Full Text Available

1980-08-01

331

Heterogeneous catalytic alcoholysis of benzonitrile  

Energy Technology Data Exchange (ETDEWEB)

The authors investigate the possibility of the direct heterogeneous catalytic synthesis of ethylbenzoate from benzonitrile. The catalysts tested were oxides of aluminium, titanium, and vanadium. The main conversion product detected chromatographically was ethylbenzoate; benzaldehyde, benzamide, and benzanilide were also identified. Aluminium oxide was found to be the most effective catalyst.

1986-04-01

332

Heritability of Measures of Kidney Disease Among Zuni Indians: The Zuni Kidney Project  

UK PubMed Central (United Kingdom)

BackgroundThe long-term goal of the GKDZI (Genetics of Kidney Disease in Zuni Indians) Study is to identify genes, environmental factors, and genetic-environmental...Full Text Available

2010-08-01

333

Hepatic stellate cells and parasite-induced liver fibrosis  

UK PubMed Central (United Kingdom)

Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important...Full Text Available

334

Health professionals rarely record history of complementary and alternative medicines  

UK PubMed Central (United Kingdom)

AimsTo identify the completeness of documentation of Complementary And Alternative Medicine (CAM) use in hospital medical records of patients before and after an education programme.Full Text Available

2005-02-01

335

Half-trek criterion for generic identifiability of linear structural equation models  

CERN Document Server

A linear structural equation model relates random variables of interest and corresponding Gaussian noise terms via a linear equation system. Each such model can be represented by a mixed graph in which directed edges encode the linear equations, and bidirected edges indicate possible correlations among noise terms. We study parameter identifiability in these models, that is, we ask for conditions that ensure that the edge coefficients and correlations appearing in a linear structural equation model can be uniquely recovered from the covariance matrix of the associated normal distribution. We treat the case of generic identifiability, where unique recovery is possible for almost every choice of parameters. We give a new graphical criterion that is sufficient for generic identifiability. It improves criteria from prior work and does not require the directed part of the graph to be acyclic. We also develop a related necessary ...

2011-01-01

336

HIV prevention for South African youth: which interventions work? A systematic review of current evidence  

UK PubMed Central (United Kingdom)

BackgroundIn South Africa, HIV prevalence among youth aged 15-24 is among the world's highest. Given the urgent need to identify effective HIV prevention approaches, this review...Full Text Available

337

Granite Countertops and Radiation | Radiation Protection | US EPA  

Wastenet

... Top of page Testing Radiation coming from granite countertops results from natural radioactive material in the granite. Identifying the presence and concentration of radioactive elements in granite requires expensive and sophisticated portable instruments or laboratory equipment. These instruments and equipment require proper calibration, and interpretation of ...

338

Genome-Wide Identification and Evolutionary Analysis of the Animal Specific ETS Transcription Factor Family  

UK PubMed Central (United Kingdom)

The ETS proteins are a family of transcription factors (TFs) that regulate a variety of biological processes. We made genome-wide analyses to explore the classification of the ETS gene family. We identified...Full Text Available

339

Genetic architecture of voluntary exercise in an advanced intercross line of mice  

UK PubMed Central (United Kingdom)

Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations and effects...Full Text Available

2010-07-01

340

Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease  

UK PubMed Central (United Kingdom)

Despite the recent success of genome-wide association studies (GWASs) in identifying loci consistently associated with coronary artery disease (CAD), a large proportion of the genetic components of...Full Text Available

341

Fast, Scalable, Bayesian Spike Identification for Multi-Electrode Arrays  

UK PubMed Central (United Kingdom)

We present an algorithm to identify individual neural spikes observed on high-density multi-electrode arrays (MEAs). Our method can distinguish large numbers of distinct neural units, even when spikes...Full Text Available

342

Factors governing the periodic activation of supraoptic and paraventricular neurosecretory cells during suckling in the rat.  

UK PubMed Central (United Kingdom)

1. One hundred and thirty-two antidromically identified paraventricular (PV) and supraoptic (SO) neurones were studied during milk ejection evoked by the suckling of the young, in thirty-four lactating...Full Text Available

1975-09-01

343

Expression and purification of a functional human hepatitis B virus polymerase  

UK PubMed Central (United Kingdom)

AIM: To identify a method for efficient large-scale purification of functional hepatitis B virus polymerase (HBV-Pol) without addition of cellular factors.METHODS: Full-length HBV-Pol (843 amino...Full Text Available

2010-12-07

344

Expression and Trans-Specific Polymorphism of Self-Incompatibility RNases in Coffea (Rubiaceae)  

UK PubMed Central (United Kingdom)

Self-incompatibility (SI) is widespread in the angiosperms, but identifying the biochemical components of SI mechanisms has proven to be difficult in most lineages. Coffea (coffee;...Full Text Available

345

Exome sequencing identifies GRIN2A as frequently mutated in melanoma  

UK PubMed Central (United Kingdom)

The incidence of melanoma is increasing more than any other cancer, and knowledge of its genetic alterations is limited. To systematically analyze such alterations, we performed whole-exome...Full Text Available

2011-05-01

346

Evaluation of the OptiMAL Test for Rapid Diagnosis of Plasmodium vivax and Plasmodium falciparum Malaria  

UK PubMed Central (United Kingdom)

The development of rapid and specific diagnostic tests to identify individuals infected with malaria is of paramount importance in efforts to control the severe public health impact of this disease....Full Text Available

1998-01-01

347

Evaluation of Acyl Coenzyme A Oxidase (Aox) Isozyme Function in the n-Alkane-Assimilating Yeast Yarrowia lipolytica  

UK PubMed Central (United Kingdom)

We have identified five acyl coenzyme A (CoA) oxidase isozymes (Aox1 through Aox5) in the n-alkane-assimilating yeast Yarrowia lipolytica, encoded by the POX1...Full Text Available

1999-09-01

348

Evaluating the Involvement of Alternative Sigma Factors SigF and SigG in Clostridium perfringens Sporulation and Enterotoxin Synthesis?  

UK PubMed Central (United Kingdom)

Clostridium perfringens type A food poisoning is the second most commonly identified bacterial food-borne illness. Sporulation contributes to this disease in two ways: (i) most food-poisoning...Full Text Available

2010-10-01

349

Establishment of an Immunoglobulin M Antibody-Forming Cell Response Model for Characterizing Immunotoxicity in Primary Human B Cells  

UK PubMed Central (United Kingdom)

Rodent models have been extensively utilized to identify putative human immunotoxicants; however, even when immunotoxicity is established, uncertainty remains whether the effects are predictive of human...Full Text Available

2009-12-01

350

Energy Performance Contracting for New Buildings  

Wastenet

situ by isolating portions of the building envelope and performing tests .MAXIMUM ALLOWED LOAD ...and shall identify commissioning team members who will perform testing and prepare documentation.The commissioning agent may be

351

Employing Kirkpatrick's Evaluation Framework to Determine the Effectiveness of Health Information Management Courses and Programs  

UK PubMed Central (United Kingdom)

Evaluation of the impact and effectiveness of courses is necessary so that strengths and weaknesses can be identified and improvements made. This article uses Kirkpatrick's evaluation framework to present...Full Text Available

352

Distribution of lead-203 in human peripheral blood in vitro.  

UK PubMed Central (United Kingdom)

In-vitro experiments using 203Pb were performed to identify the lead binding components in human peripheral blood. The distribution of lead in plasma, in the red cell membrane, and within the red cell...Full Text Available

1980-02-01

353

Differential neural contributions to native- and foreign-language talker identification  

UK PubMed Central (United Kingdom)

Humans are remarkably adept at identifying individuals by the sound of their voice, a behavior supported by the nervous system’s ability to integrate information from voice and speech...Full Text Available

2009-12-01

354

Developing IT Infrastructure for Rural Hospitals: A Case Study of Benefits and Challenges of Hospital-to-Hospital Partnerships  

UK PubMed Central (United Kingdom)

This article presents a study identifying benefits and challenges of a novel hospital-to-hospital information technology (IT) outsourcing partnership (HHP). The partnership is an innovative response...Full Text Available

2008-07-01

355

Detection and Identification of Ciprofloxacin-Resistant Yersinia pestis by Denaturing High-Performance Liquid Chromatography  

UK PubMed Central (United Kingdom)

Denaturing high-performance liquid chromatography (DHPLC) has been used extensively to detect genetic variation. We used this method to detect and identify Yersinia pestis KIM5 ciprofloxacin-resistant...Full Text Available

2003-07-01

356

Delineating Bacteriostatic and Bactericidal Targets in Mycobacteria Using IPTG Inducible Antisense Expression  

UK PubMed Central (United Kingdom)

In order to identify novel high value antibacterial targets it is desirable to delineate whether the inactivation of the target enzyme will lead to bacterial death or stasis. This knowledge is particularly...Full Text Available

357

Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence  

UK PubMed Central (United Kingdom)

The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia. Interest in this zoonotic pathogen has increased due to its classification as a category A agent...Full Text Available

2006-08-22

358

Deep Desulfurization of Diesel Oil and Crude Oils by a Newly Isolated Rhodococcus erythropolis Strain  

UK PubMed Central (United Kingdom)

The soil-isolated strain XP was identified as Rhodococcus erythropolis. R. erythropolis XP could efficiently desulfurize benzonaphthothiophene, a complicated model sulfur compound that...Full Text Available

2006-01-01

359

DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase  

UK PubMed Central (United Kingdom)

CDC7 is an essential gene required for DNA replication in Saccharomyces cerevisiae. Cdc7p homologs have recently been identified in vertebrates, but their role in DNA...Full Text Available

1999-03-16

360

DECOMP: A PDB decomposition tool on the web  

UK PubMed Central (United Kingdom)

The protein databank (PDB) contains high quality structural data for computational structural biology investigations. We have earlier described a fast tool (the decomp_pdb tool) for identifying and...Full Text Available

361

Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies.  

UK PubMed Central (United Kingdom)

The authors have recently identified a new cytokeratin (CK) polypeptide, CK 20, whose expression is almost entirely confined to the gastric and intestinal epithelium, urothelium, and Merkel cells. Seven...Full Text Available

1992-02-01

362

Coryneform bacteria in infectious diseases: clinical and laboratory aspects.  

UK PubMed Central (United Kingdom)

Coryneform isolates from clinical specimens frequently cannot be identified by either reference laboratories or research laboratories. Many of these organisms are skin flora that belong to a large number...Full Text Available

1990-07-01

363

Confirmation of human Campylobacter concisus isolates misidentified as Campylobacter mucosalis and suggestions for improved differentiation between the two species.  

UK PubMed Central (United Kingdom)

A strain from human diarrhea originally identified as Campylobacter mucosalis (NCTC 12408) was examined by using 64 phenotypic characters. The similarity of this strain to 297 isolates of Campylobacter,...Full Text Available

1994-09-01

364

Comparison of Different Measures of Urinary Protein Excretion for Prediction of Renal Events  

UK PubMed Central (United Kingdom)

There are many methods to screen for abnormal amounts of proteinuria to identify patients at risk for progression of renal disease, but which method best predicts renal risk is unknown. Here, we analyzed...Full Text Available

2010-08-01

365

Comparative analysis of cis-regulation following stroke and seizures in subspaces of conserved eigensystems  

UK PubMed Central (United Kingdom)

BackgroundIt is often desirable to separate effects of different regulators on gene expression, or to identify effects of the same regulator across several systems. Here, we focus...Full Text Available

366

Coal to liquids technology (Overview - Research)  

Wastenet

... After completing a review into direct coal liquefaction research carried out in Australia and internationally, CSIRO has identified potential new science and technology developments that may improve the cost and viability of CTL in a greenhouse gas-constrained environment. We are conducting research to: determine the optimum ...

367

Clinical Correlates to Laboratory Measures for use in Non-Contact Anterior Cruciate Ligament Injury Risk Prediction Algorithm  

UK PubMed Central (United Kingdom)

BackgroundProspective measures of high knee abduction moment during landing identify female athletes at high risk for non-contact anterior cruciate ligament injury....Full Text Available

2010-08-01

368

Climate Change, Genetics or Human Choice: Why Were the Shells of Mankind's Earliest Ornament Larger in the Pleistocene Than in the Holocene?  

UK PubMed Central (United Kingdom)

BackgroundThe southern African tick shell, Nassarius kraussianus (Dunker, 1846), has been identified as being the earliest known ornamental object used by human...Full Text Available

369

Characterization of Two Unique Cholesterol-Rich Lipid Particles Isolated from Human Atherosclerotic Lesions  

UK PubMed Central (United Kingdom)

The authors' laboratory, using histochemicalmethods, previously identified two types of cholesterol-containing lipid particles in the extracellular spaces of human atherosclerotic lesions, one particle...Full Text Available

1990-01-01

370

Chaotic system of two-phase flow in a small, horizontal, rectangular channel.  

Science.gov (United States)

Various measurement tools that are used in chaos theory were applied to analyze two-phase pressure signals with the objective of identifying and interpreting flow pattern transitions for two-phase flows in a small, horizontal rectangular channel. These me...

1995-01-01

371

Central gating of fly optomotor response  

UK PubMed Central (United Kingdom)

We study the integration of multisensory and central input at the level of an identified fly motoneuron, the ventral cervical nerve motoneuron (VCNM) cell, which controls head movements of the animal....Full Text Available

2010-11-16

372

Carpal Tunnel Syndrome and Peripheral Polyneuropathy in Patients with End Stage Kidney Disease  

UK PubMed Central (United Kingdom)

This study was designed to identify the causes of the development of carpal tunnel syndrome (CTS) associated with end stage kidney disease (ESKD). A total of 112 patients with ESKD, 64 on hemodialysis...Full Text Available

2011-09-01

373

Cancer in young people in the north of England, 1968-85: analysis by census wards.  

UK PubMed Central (United Kingdom)

OBJECTIVE--To determine whether the seeming excess of childhood leukaemia and lymphoma identified in Seascale, Cumbria, UK, remains unusual when put into a wider context. DESIGN--Analysis of cancer...Full Text Available

1993-04-01

374

CD133 Positive Embryonal Rhabdomyosarcoma Stem-Like Cell Population Is Enriched in Rhabdospheres  

UK PubMed Central (United Kingdom)

Cancer stem cells (CSCs) have been identified in a number of solid tumors, but not yet in rhabdomyosarcoma (RMS), the most frequently occurring soft tissue tumor in childhood. Hence, the aim of this...Full Text Available

375

Burnout sensitivity of power MOSFETs operating in a switching converter  

International Nuclear Information System (INIS)

Heavy ion tests of a switching converter using power MOSFETs have allowed us to identify the main parameters which affect the burnout sensitivity of these components. The differences between static and dynamic conditions are clarified in this paper. (author). 7 refs., 16 figs., 3 tabs.

376

Brain transcriptomic analysis in paper wasps identifies genes associated with behaviour across social insect lineages  

UK PubMed Central (United Kingdom)

Comparative sociogenomics has the potential to provide important insights into how social behaviour evolved. We examined brain gene expression profiles of the primitively eusocial wasp Polistes...Full Text Available

2010-07-22

377

Boron Tolerance in Barley Is Mediated by Efflux of Boron from the Roots1  

UK PubMed Central (United Kingdom)

Many plants are known to reduce the toxic effects of high soil boron (B) by reducing uptake of B, but no mechanism for limiting uptake has previously been identified. The B-tolerant cultivar of barley...Full Text Available

2004-10-01

378

Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound  

UK PubMed Central (United Kingdom)

Fish living in contaminated environments accumulate toxic chemicals in their tissues. Biomarkers are needed to identify the resulting health effects, particularly focusing on early changes at a subcellular...Full Text Available

2006-06-01

379

Biochemical analysis of PIFTC3, the Trypanosoma brucei ortholog of nematode DYF-13, reveals interactions with established and putative intraflagellar transport components  

UK PubMed Central (United Kingdom)

DYF-13, originally identified in C. elegans within a collection of dye-filling chemosensory mutants, is one of several proteins that have been classified as putatively involved...Full Text Available

2010-10-01

380

Biobank resources for future patient care: developments, principles and concepts  

UK PubMed Central (United Kingdom)

The aim of the overview is to give a perspective of global biobank development is given in a view of positioning biobanking as a key resource for healthcare to identify new potential markers that can...Full Text Available

381

Bacterial response to siderophore and quorum-sensing chemical signals in the seawater microbial community  

UK PubMed Central (United Kingdom)

BackgroundOceans are iron-deficient and nutrient-poor environments. These conditions impart limitations on our understanding of and our ability to identify microorganisms from the...Full Text Available

382

Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells  

UK PubMed Central (United Kingdom)

The CD1 family of proteins binds self and foreign glycolipids for presentation to CD1-restricted T cells. To identify previously uncharacterized active CD1 ligands, especially those of microbial origin,...Full Text Available

2005-02-01

383

Bacterial Competition for Human Nasal Cavity Colonization: Role of Staphylococcal agr Alleles  

UK PubMed Central (United Kingdom)

We examined the bacterial aerobic nasal flora of 216 healthy volunteers to identify potential competitive interactions among different species, with special emphasis on the influence of staphylococcal...Full Text Available

2003-01-01

384

Autophosphorylation Within the Atg1 Activation Loop Is Required for Both Kinase Activity and the Induction of Autophagy in Saccharomyces cerevisiae  

UK PubMed Central (United Kingdom)

Autophagy is an evolutionarily conserved degradative pathway that has been implicated in a number of physiological events important for human health. This process was originally identified as a response...Full Text Available

2010-07-01

385

Associations between dairy production indices and lipoarabinomannan enzyme-immunoassay results for paratuberculosis.  

UK PubMed Central (United Kingdom)

Data from an epidemiological study in Ontario, involving 304 dairy herds, were used to identify associations between selected production indices and lipoarabinomannan antigen serological test results...Full Text Available

1991-10-01

386

Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study  

UK PubMed Central (United Kingdom)

IntroductionThe goal of this study was to identify serum markers that are modulated by treatment with golimumab with or without methotrexate (MTX) and are associated with clinical...Full Text Available

2010-01-01

387

Army energy plan. Technical report  

Science.gov (United States)

The Plan identifies the Army's organization, goals, objectives, and policies with respect to energy. It projects energy consumption and costs to the year 2000 and summarizes the programs required to support the long range goals. A summary of current and needed energy related legislation is included. (Author)

1978-02-24

388

Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-?B-dependent iNOS and proinflammatory cytokines production  

UK PubMed Central (United Kingdom)

Background and purpose:Glycyrrhizae radix has been widely used as a cytoprotective, plant-derived medicine. We have identified a flavanoid, liquiritigenin, as an...Full Text Available

2008-05-01

389

Anti-beta-endorphin immunoglobulin G in humans.  

UK PubMed Central (United Kingdom)

Human IgG specific for beta-endorphin was identified by enzyme-linked immunoabsorbent assay and isolated by affinity chromatography. From a sample of 27 subjects, three individuals with major depression...Full Text Available

1986-11-01

390

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast  

UK PubMed Central (United Kingdom)

BackgroundHistone post-translational modifications are critical for gene expression and cell viability. A broad spectrum of histone lysine residues have been identified in yeast...Full Text Available

391

Analysis of target cell susceptibility as a basis for the development of a chemoprotective strategy against benzene-induced hematotoxicities.  

UK PubMed Central (United Kingdom)

A goal of our research is to identify biochemical factors that underlie the susceptibility of bone marrow cell populations to benzene metabolites so as to develop a mechanistically based chemoprotective...Full Text Available

1996-12-01

392

Analysis of Failed Spinal Cord Stimulation Trials in the Treatment of Intractable Chronic Pain  

UK PubMed Central (United Kingdom)

ObjectiveThe purpose of this study is to identify the factors affecting the failure of trials (<50% pain reduction in pain for trial period) to improve success rate of spinal...Full Text Available

2008-02-01

393

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer  

UK PubMed Central (United Kingdom)

BackgroundGenomics has substantially changed our approach to cancer research. Gene expression profiling, for example, has been utilized to delineate subtypes of cancer, and facilitated...Full Text Available

394

An Intrinsic Neuronal Oscillator Underlies Dopaminergic Neuron Bursting  

UK PubMed Central (United Kingdom)

Dopaminergic neurons of the ventral midbrain fire high frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can...Full Text Available

2009-12-16

395

Amazon.com: Customer Reviews: Womenomics: Write Your Own Rules for Success  

Wastenet

...Own Rules for Success (Hardcover) The authors have rightly identified that there is a growing demand for, trend towards, and interest in guidance for creating flexible working arrangements. However, for $27.99, you can secure more concrete advice on reaching your \\

396

Alcohol and the fetus in the west of Scotland.  

UK PubMed Central (United Kingdom)

Forty children with the fetal alcohol syndrome were identified in the west of Scotland. All were growth retarded and had abnormal facial features, and all those who were tested were found to have neurological...Full Text Available

1983-07-02

397

Accuracy of Contacts Calculated from 3D Images of Occlusal Surfaces  

UK PubMed Central (United Kingdom)

ObjectiveCompare occlusal contacts calculated from 3D virtual models created from clinical records to contacts identified clinically using shimstock and transillumination.Full Text Available

2007-06-01

398

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death  

UK PubMed Central (United Kingdom)

SUMMARYATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as...Full Text Available

2010-08-20

399

A polyacetylene compound from herbal medicine regulates genes associated with thrombosis in endothelial cells  

UK PubMed Central (United Kingdom)

From Toki-shakuyaku-san, an herbal formulation for “cleansing stagnated blood,” a key gene regulatory compound was purified and identified through a screening based on DNA microarray...Full Text Available

2007-12-15

400

A new VCAN/versican splice acceptor site mutation in a French Wagner family associated with vascular and inflammatory ocular features  

UK PubMed Central (United Kingdom)

PurposeTo detail the highly variable ocular phenotypes of a French family affected with an autosomal dominantly inherited vitreoretinopathy and to identify the disease gene.MethodsSixteen...Full Text Available

401

A Web-based Interface for Communication of Data between the Clinical and Research Environments without Revealing Identifying Information  

UK PubMed Central (United Kingdom)

Recent health care policies and regulations have impacted the manner in which patient data – especially protected health information (PHI) – are handled in both the clinical...Full Text Available

2007-06-01

402

A Novel Mouse Model of Red Blood Cell Storage and Post-Transfusion in Vivo Survival  

UK PubMed Central (United Kingdom)

BackgroundStorage of RBCs is necessary for an adequate blood supply. However, reports have identified potential negative sequelae of transfusing stored RBCs. An animal...Full Text Available

2009-08-01

403

A NEW APPROACH TO UNDERSTANDING THE MOLECULAR MECHANISMS THROUGH WHICH ESTROGENS AFFECT COGNITION  

UK PubMed Central (United Kingdom)

Traditional approaches to the study of hormones and cognition have been primarily observational or correlational in nature. Because this work does not permit causal relationships to be identified,...Full Text Available

2010-10-01

404

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice  

UK PubMed Central (United Kingdom)

Humanin (HN), a 24-residue peptide, was identified as a novel neuroprotective factor and shows anti-cell death activity against a wide spectrum of Alzheimer's disease (AD)-related cytotoxicities, including...Full Text Available

405

A Hemorrhagic Factor (Apicidin) Produced by Toxic Fusarium Isolates from Soybean Seeds  

UK PubMed Central (United Kingdom)

Fifty-two isolates of Fusarium species were obtained from soybean seeds from various parts of Korea and identified as Fusarium oxysporum, F. moniliforme,...Full Text Available

1999-01-01

406

A Disordered Eating Response Team's Effect on Nutrition Practices in College Athletes  

UK PubMed Central (United Kingdom)

The disordered eating response team developed a protocol for assessment and intervention for athletes who are identified as at risk for disordered eating. Team members included the team physician,...Full Text Available

1995-10-01

407

A Cytogenetic Abnormality and Rare Coding Variants Identify ABCA13 as a Candidate Gene in Schizophrenia, Bipolar Disorder, and Depression  

UK PubMed Central (United Kingdom)

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of ∼80% indicating a substantial genetic component. Population genetics...Full Text Available

2009-12-11

408

A Computer Vision System for Automated Grading of Rough Hardwood Lumber Using a Knowledge-Based Approach  

Science.gov (United States)

... in this paper is aimed at developing a computer vision system that will be used to automatically grade rough hardwood lumber. The purpose of the computer vision system is to locate and identify grading def...

409

A Comparison of intra-oral digital imaging modalities: Charged Couple Device versus Storage Phosphor Plate  

UK PubMed Central (United Kingdom)

BackgroundThis in vitro study was conducted to compare the accuracy of two digital image receptors in identifying the location of tip of a fine endodontic file and radiographic apex...Full Text Available

2010-11-01

410

45 CFR 1175.110 - Self-evaluation.  

Science.gov (United States)

...shall, until three years following the completion of the self-evaluation, maintain on file and make available for public inspections: (1) A description of areas examined and any problems identified, and (2) A description of any...

2010-10-01

411

1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis  

UK PubMed Central (United Kingdom)

BackgroundPathophysiological mechanisms involved in amyotrophic lateral sclerosis (ALS) are complex and none has identified reliable markers useful in routine patient evaluation....Full Text Available

412

Waste Sampling and Characterization Facility (WSCF). Maintenance Implementation Plan  

Energy Technology Data Exchange (ETDEWEB)

This Maintenance Implementation Plan has been developed for maintenance functions associated with the Waste Sampling and Characterization Facility (WSCF). This plan is developed from the guidelines presented by Department of Energy (DOE) Order 4330.4A, Maintenance Management Program (DOE 1990), Chapter II. The objective of this plan is to provide baseline information for establishing and identifying WHC conformance programs and policies applicable to implementation of DOE order 4330.4A guidelines. In addition, this maintenance plan identifies the actions necessary to develop a cost-effective and efficient maintenance program at WSCF.

1993-07-01

413

Theory and method for selection of power system stabilizer location  

Energy Technology Data Exchange (ETDEWEB)

A new approach for the selection of best PSS locations in multimachine power systems is proposed in this paper. Study shows that the right-eigenvector measures the activity of state variables and the left-eigenvector measures the control effect of control signals. Based on the right and left eigenvector the concept of sensitivity of PSS effect (SPE) is presented and used to identify the best PSS locations. The proposed method is used to identify the best PSS location in a 13-machine system to increase the damping of an interarea mode. The time-domain simulation results confirm that the prediction of best PSS location by SPE method is correct and accurate.

1991-03-01

414

RAPID DAMAGE ASSESSMENT FROM HIGH RESOLUTION IMAGERY  

Energy Technology Data Exchange (ETDEWEB)

Disaster impact modeling and analysis uses huge volumes of image data that are produced immediately following a natural or an anthropogenic disaster event. Rapid damage assessment is the key to time critical decision support in disaster management to better utilize available response resources and accelerate recovery and relief efforts. But exploiting huge volumes of high resolution image data for identifying damaged areas with robust consistency in near real time is a challenging task. In this paper, we present an automated image analysis technique to identify areas of structural damage from high resolution optical satellite data using features based on image content.

2008-07-01

415

Patient isolation in chronic benign pain.  

Science.gov (United States)

Over the years, nurses, doctors and scientists have sought ways of assessing the impact of pain on patients. While many of the instruments devised have been extremely useful in identifying the nature and intensity of pain, defining the effect it has on people's lives and perceptions has proved much more problematic. Based on the work she carried out with patients suffering from chronic benign pain, Karen Rose explores one aspect of these effects--the feeling of isolation. By using a four-step anthropological approach to identify the impact of pain, she argues, nurses can arrive at a realistic and accurate assessment of how patients are coping. PMID:7947167

416

Opportunities for coal liquefaction research in British Columbia  

Energy Technology Data Exchange (ETDEWEB)

This paper presents the results of a study commissioned by the British Columbia Science Council to identify opportunities for liquefaction of B.C. coals and to recommend effective approaches to the development of a research program on coal conversion. Contains reviews of British Columbia coal resources to identify prospective candidates for conversion to liquid fuels; of the state of the art in the various processes for the conversion of coal to liquid fuels with particular emphasis on those processes most relevant to British Columbia applications; and of research opportunities in British Columbia for the development of coal liquefaction technology. (16 refs.)

1980-05-01

417

Lack of awareness of symptoms in people with dementia: the structural and functional basis  

British Library Electronic Table of Contents (United Kingdom)

AbstractObjective To review studies investigating the brain correlates of unawareness of cognitive and behavioural symptoms in people with dementia. Design A detailed search of the literature was conducted to include all the peer-reviewed studies published in English aimed at identifying the structural or functional brain correspondents of unawareness in dementia patients. Their results were interpreted in relation to the methodological differences in terms of type of dementia studied, the protocol adopted to measure lack of awareness, the imaging techniques employed, the experimental designs and statistical analyses performed. Results Eighteen studies undertaken to explore the functional and structural correlates of unawareness of cognitive symptoms in dementia were identified. Although t...

2011-01-01

418

How the Energy and Water Development Appropriations Act of 1993 has impacted the constitutional dynamics of federal wetlands delineation and regulation  

Energy Technology Data Exchange (ETDEWEB)

A reliable source of specific criteria for recognizing a wetland, as defined for regulatory purposes would be valuable. In 1987 the Army Corps of Engineers developed a technical manual for identifying wetlands (1987 Wetlands Manual). An interagency manual (1989 Wetlands Manual) was later developed. This manual has been used to identify wetlands according to three evidentiary factors: vegetation, hydrology, and soil. This paper addresses the development of criteria to delineate wetlands, and describes some of the logic used by federal courts to uphold the limited constitutional use of the 1989 Wetlands Manual.

1995-12-31

419

Hazard Evaluation for the Saltwell Chempump and a Saltwell Centrifugal Pump Design using Service Water for Lubrication and Cooling  

Energy Technology Data Exchange (ETDEWEB)

This report documents results of a preliminary hazard analysis (PHA) covering the existing Crane Chempump and the new salt well pumping design. Three hazardous conditions were identified for the Chempump and ten hazardous conditions were identified for the new salt well pump design. This report also presents the results of the control decision/allocation process. A backflow preventer and associated limiting condition for operation were assigned to one hazardous condition with the new design.

2000-11-16

420

Effect of the size of an artificial neural network used as pattern identifier  

Energy Technology Data Exchange (ETDEWEB)

A novel way to extract relevant parameters associated with the outgoing ions from nuclear reactions, obtained by digitizing the signals provided by a Bragg curve spectrometer (BCS) is presented. This allowed the implementation of a more thorough pulse-shape analysis. Due to the complexity of this task, it was required to take advantage of new and more powerful computational paradigms. This was fulfilled using a back-propagation artificial neural network (ANN) as a pattern identifier. Over training of ANNs is a common problem during the training stage. In the performance of the ANN there is a compromise between its size and the size of the training set. Here, this effect will be illustrated in relation to the problem of Bragg Curve (BC) identification. (Author)

2003-07-01

421

Cost-time management: A powerful tool in a new application - cleaning up the weapons complex  

International Nuclear Information System (INIS)

Westinghouse Electric Corporation is aggressively applying cost-time management to bolster timely, cost-effective cleanup and waste management activities at sites it manages for the U.S. Department of Energy (DOE). Cost-time management is a diagnostic technique which is applicable to virtually any process. It identifies opportunities to reduce cycle-times and costs. When applied to cleanup and waste management at DOE facilities, cost-time profile analysis helps identify actions to improve productivity and quality. Moreover, by reducing cycle-times and costs, it achieves significant savings to taxpayers. (author)

1992-03-01

422

Competencies of Employment Specialists for Effective Job Development  

British Library Electronic Table of Contents (United Kingdom)

A scant body of literature addresses competencies needed for successful job development. This study aimed to identify competencies needed for this role. In this analysis, we observed employment specialists identified as successful in helping consumers obtain employment perform job development duties. We supplemented observations with interviews. Employment specialists possessed competencies in six domains: time management, advocacy, building partnerships with consumers, working as part of a team, face-to-face communication, and networking. The conceptual framework derived from this study can inform supported employment supervisors and researchers about the competencies that can strengthen supported employment teams.

2011-01-01

423

Neutron activation analysis for determination of selected trace elements responsible for immunity in foodstuffs and water in egypt  

International Nuclear Information System (INIS)

Selenium (Se), zinc (Zn), magnesium (Mg), molybdenum (Mo) and vanadium (V) in 28 types of Egyptian common foodstuffs as well as drinking and irrigation water samples were determined using neutron activation analysis (NAA) and atomic absorption spectrometry (AAS). The samples were collected from 74 sites over 13 governorates as well as the Nile river, wells and tap water in the regions of the Nile Delta, Sinai, the east and west desert, and north and south Egypt. These trace elements were chosen according to international references, which show the close relationship of their deficiencies to immunity-related diseases. Calculation values of daily uptake per capita were made with the results of analysis. The results, as calculated per 100 g dry weight, showed that some Egyptian foods are rich in Se including such fish (0.94 #mu#g), sesame (0.88 #mu#g), beef meat (0.48 #mu#g), instant tea (0.42 #mu#g), mushroom (0.34 #mu#g) and eggs (0.3 #mu#g), whereas the vegetables contained less than ...

424

Dosimetric Implications of Atmospheric Dispersal of Tritium Near a Heavy-water Research Reactor Facility  

Energy Technology Data Exchange (ETDEWEB)

An estimate of the tritium dose to the public in the vicinity of the heavy water research reactor facility at AECL-Chalk River Laboratories, Ontario, Canada, has largely been accomplished from analyses on regularly-collected samples of air, precipitation, drinking water and foodstuffs (pasture, fruit, vegetables and milk) and environmental dose models. To increase the confidence with which public doses are calculated, tritium doses were estimated directly from the ratio of tritiated species in urine samples from members of the general public. Single cumulative 24 h urine samples from a few adults living in the vicinity of the heavy-water research reactor facility at Chalk River Laboratories, Canada were collected and analysed for tritiated water and organically bound tritium. The participants were from Ottawa (200 km east), Deep River (10 km west) and Chalk River Laboratories. Tritiated water concentrations in urine ranged from 6.5 Bq.l{sup -1} for the Ottawa resident to 15.9 Bq.l{sup ...

2001-07-01

425

Clinically silent heterotaxy with polysplenia syndrome and IVC azygous continuation draining to SVC: CT findings. Case report  

International Nuclear Information System (INIS)

Patients with heterotaxy syndrome often have complex cardiac and extracardiac anomalies requiring further detailed diagnostic evaluation. They often present severe cardiac failure early in life. Newer radiological modalities in the form of spiral computed tomography (CT) and three-dimensional reconstruction of spiral CT allow clear definition of the anatomy of these anomalies. A 59-year-old woman was diagnosed with polysplenia and multiple anomalies in an abdominal ultrasonography (US) during a control medical examination due to a trivial dietary mistake. She was then referred to our institution for further examination of these anomalies and an additional thoraco-abdominal computed tomography (CT) examination. The patient was totally asymptomatic at the time of admission. There was no significant past history and no abnormal laboratory data. We performed abdominal, pelvic and thoracic CT examinations using Somatom Siemens Emotion scanner. Non-enhanced sections were ...

2007-01-01

426

Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.  

Science.gov (United States)

African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more productive Bos indicus zebu breeds are much more susceptible. Zebu cattle are well adapted for plowing and haulage, and increasing their tolerance of trypanosomiasis could have a major impact on crop cultivation as well as dairy and beef production. We used three strategies to obtain short lists of candidate genes within QTL that were previously shown to regulate response to infection. We analyzed the transcriptomes of trypanotolerant N'Dama and susceptible Boran cattle after infection with Trypanosoma congolense. We sequenced EST libraries from these two breeds to identify polymorphisms that might underlie previously identified quantitative trait loci (QTL), and we assessed QTL regions and candidate loci for evidence of selective ...

2011-05-18

427

Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution  

Energy Technology Data Exchange (ETDEWEB)

The DNA sequence motif ATTTGCAT (octamer) or its inverse complement has been identified as an evolutionarily conserved element in the promoter region of immunoglobulin genes. Two major DNA-binding proteins that bind in a sequence-specific manner to the octamer DNA sequence have been identified in mammalian species--a ubiquitously expressed protein (Oct-1) and a lymphoid-specific protein (Oct-2). During characterization of the promoter region of the chicken immunoglobulin light chain gene, the authors identified two homologous octamer-binding proteins in chicken B cells. when the cloning of the human gene for Oct-2 revealed it to be a member of a distinct family of homeobox genes, they sought to determine if the human Oct-2 cDNA could be used to identify homologous chicken homeobox genes. Using a human Oct-2 homeobox-specific DNA probe, they were able to identify 6-10 ...

1990-02-01

428

Virtual colonoscopy (CT colonography) in the identification of colorectal cancer. A prospective study in symptomatic patients  

International Nuclear Information System (INIS)

Aim of this study was to evaluate the sensitivity of virtual colonoscopy (CT colonography) in the identification of colorectal cancer and to define the limitations and the advantages of this imaging modality, as well as indications to the examination. It was examined prospectively 62 symptomatic patients aged 36 to 82 years (28 women and 34 men). All patients underwent both conventional and virtual colonoscopy on the same day; the conventional examination allowed exploration of the entire colon. Conventional colonoscopy identified 89 lesions 3-50 mm in diameter, namely 84 benign and 5 malignant lesions. No lesions were identified in 12 patients. CT colonography identified 52 of the 89 lesions, with 57.1% diagnostic accuracy. They were 11 false positives (82.5% positive predictive value and 52.2% specificity) and 37 false negatives (24.5% negative predictive value and 58.4% sensitivity). Sensitivity was significantly higher ...

2000-06-01

429

Transient performance of FFTF [Fast Flux Test Facility] reference fuel  

International Nuclear Information System (INIS)

Fourteen irradiated Fast Flux Test Facility (FFTF) fuel pins were subjected to representative overpower transients in six flowing sodium loop experiments conducted in the TREAT reactor. The transient tests were extended to substantial overpower levels well beyond protected levels, with some tests intentionally run to failure to identify failure thresholds and characteristics. Test variables included transient ramp rate (5, 50, and 100 cents/s) and burnup (2 to 58 MWd/kg). Performance limits and failure characteristics were identified, and cladding strain and fuel melting data were obtained for development and verification of transient analysis codes. The test results demonstrated that FFTF Reference fuel pins are capable of surviving overpower levels well beyond the FFTF secondary Plant Protection System (PPS) trip limit of 1.25 times normal rated power. Based on analytical evaluations to interpolate and extrapolate test results to the full ...

1986-09-07

430

Reflexibility in Problem Solving: The Social Context of Expertise. Report No. 13.  

Science.gov (United States)

A series of studies conducted to identify the factors that block and unblock problem solving is described. Through the construction of an isomorph of the classic "water jar" problems developed by A. S. Luchins (1942) as a dynamic graphic micro-world, several factors involved in producing blocked states were identified. Subjects included 10 individuals and 10 pairs of subjects. By comparing the behavior of individuals tackling the "missionaries and cannibals" problem to that of pairs of subjects solving this problem, a study identified means by which problem solvers operating in a social context are able to overcome blocks that discourage individuals. These studies point to the importance of "reflection" (evaluation of problem-solving results) for flexible problem solving. This research suggests that teaching students to analyze what they have done will help them develop flexibility in using a new approach when blocked. The ...

1986-08-01

431

Overview of the environmental concerns of coal transportation  

Energy Technology Data Exchange (ETDEWEB)

More than 30 environmental concerns were analyzed for the transportation of coal by rail, roads (trucks), high voltage transmission lines (that is, from mine-mouth generating plants to distribution networks), coal slurry pipelines, and barges. The following criteria were used to identify these problems: (1) real physical environmetal impacts for which control technologies must be developed, or regulation made effective where control technologies presently exist; (2) the level of impact is uncertain, although the potential impact may be moderate to high; (3) the concerns identified by the first two criteria are specific to or exacerbated by coal transportation. Generic transportation problems are not included. The significant environmental problems identified as a result of this study are: (1) rail transport - community traffic disruption and human health, safety, and habitat destruction; (2) coal haul roads - road ...

1980-02-01

432

Obsidians and tektites: Natural analogues for water diffusion in nuclear waste glasses  

Energy Technology Data Exchange (ETDEWEB)

Projected scenarios for the proposed Yucca Mountain repository include significant periods of time when high relative humidity atmospheres will be present, thus the reaction processes of interest will include those known to occur under these conditions. The ideal natural analog for the proposed Yucca Mountain repository would consist of natural borosilicate glasses exposed to expected repository conditions for thousands of years; however, the prospects for identifying such an analog are remote, but an important caveat for using natural analog studies is to relate the reaction processes in the analog to those in the system of interest, rather than a strict comparison of the glass compositions. In lieu of this, identifying natural glasses that have reacted via reaction processes expected in the repository is the most attractive option. The goal of this study is to quantify molecular water diffusion in the natural analogs obsidian and tektites. ...

1991-11-01

433

Multidimensional two-phase flow regime distribution in a PWR downcomer during an LBLOCA refill phase  

Energy Technology Data Exchange (ETDEWEB)

The multidimensional countercurrent two-phase flow regimes that occur in a pressurized-water reactor (PWR) vessel downcomer during the refill phase of a large-break loss-of-coolant accident are studied using a transparent 1/10 scale model of a PWR vessel. The various flow regimes and their distribution in the downcomer have been identified and mapped for a range of air-water flooding experiments. The two-phase flow patterns that are identified in the downcomer included various types of film flows, droplet flows, countercurrent churn flows and cocurrent flows depending on the flooding condition. Through observation of the two-phase flow dynamics it was deduced that the physical mechanisms associated with the flooding processes could be separated into a liquid entrainment process and a film flow reversal process. In addition to the above exercise, the effect of non-uniform injection of water into the downcomer via different combinations of cold ...

1994-09-01

434

Multidimensional two-phase flow regime distribution in a PWR downcomer during an LBLOCA refill phase  

International Nuclear Information System (INIS)

The multidimensional countercurrent two-phase flow regimes that occur in a pressurized-water reactor (PWR) vessel downcomer during the refill phase of a large-break loss-of-coolant accident are studied using a transparent 1/10 scale model of a PWR vessel. The various flow regimes and their distribution in the downcomer have been identified and mapped for a range of air-water flooding experiments. The two-phase flow patterns that are identified in the downcomer included various types of film flows, droplet flows, countercurrent churn flows and cocurrent flows depending on the flooding condition. Through observation of the two-phase flow dynamics it was deduced that the physical mechanisms associated with the flooding processes could be separated into a liquid entrainment process and a film flow reversal process. In addition to the above exercise, the effect of non-uniform injection of water into the downcomer via different combinations of cold ...

1993-10-01

435

Gear crack level identification based on weighted K nearest neighbor classification algorithm  

Science.gov (United States)

A crack fault is one of the damage modes most frequently occurring in gears. Identifying different crack levels, especially for early cracks is a challenge in gear fault diagnosis. This paper aims to propose a method to classify the different levels of gear cracks automatically and reliably. In this method, feature parameters in time domain, specially designed for gear damage detection and in frequency domain are extracted to characterize the gear conditions. A two-stage feature selection and weighting technique (TFSWT) via Euclidean distance evaluation technique (EDET) is presented and adopted to select sensitive features and remove fault-unrelated features. A weighted K nearest neighbor (WKNN) classification algorithm is utilized to identify the gear crack levels. The gear crack experiments were conducted and the vibration signals were captured from the gears under different loads and motor speeds. The proposed method is applied to ...

2009-07-01

436

Damping inter-area modes of oscillation using an adaptive fuzzy power system stabilizer  

Energy Technology Data Exchange (ETDEWEB)

This paper introduces an indirect adaptive fuzzy controller as a power system stabilizer used to damp inter-area modes of oscillation following disturbances in power systems. Compared to the IEEE standard multi-band power system stabilizer (MB-PSS), indirect adaptive fuzzy-based stabilizers are more efficient because they can cope with oscillations at different operating points. A nominal model of the power system is identified on-line using a variable structure identifier. A feedback linearization-based control law is implemented using the identified model. The gains of the controller are tuned via a particle swarm optimization routine to ensure system stability and minimum sum of the squares of the speed deviations. A bench-mark problem of a 4-machine 2-area power system is used to demonstrate the performance of the proposed controller and to show its superiority over other conventional stabilizers used in the literature. ...

2010-12-15

437

Can We Use Common Clinical Parameters to Identify Patients Who Will Need Insulin Treatment in Gestational Diabetes?  

Science.gov (United States)

OBJECTIVE To identify patients with gestational diabetes mellitus (GDM) who will need antenatal insulin treatment (AIT) by using a risk-prediction tool based on maternal clinical and biochemical characteristics at diagnosis. RESEARCH DESIGN AND METHODS Data from 3,009 women attending the Royal Prince Alfred Hospital GDM Clinic, Australia, between 1995 and 2010 were studied. A risk engine was developed from significant factors identified for AIT using a logistic regression model. RESULTS A total of 51% of GDM patients required AIT. Ethnicity, gestation at diagnosis, HbA(1c), fasting and 60-min glucose oral glucose tolerance test, BMI, and diabetes family history were significant independent determinants of AIT. Notably, only 9% of the attributable risk for AIT can be explained by the clinical factors studied. A modeled risk-scoring system was therefore a poor predictor of AIT. CONCLUSIONS Baseline maternal characteristics including HbA(1c) alone ...

2011-08-11

438

CANMET's environmental and process research on uranium  

International Nuclear Information System (INIS)

Environmental research related to uranium tailings is being carried out within the Mining Research Laboratories and Mineral Sciences Laboratories of CANMET, EMR. Field-related research on uranium tailings has been conducted at Elliot Lake for over five years. Much of the work has been focused on a program to rehabilitate pyritic tailings. This has resulted in developing a practicable technology for growing vegetation on such wastes. Limitations have been small size of the test-plots and the relatively short period during which experiments have been carried out. A research program aimed at identifying and reducing acidic and radioactive effluents is also underway at Elliot Lake. These liquid effluents have been identified as the most serious threat to the environment. Research at the Mineral Sciences Laboratories and its predecessor divisions relating to the processing of uranium and thorium ores is outlined. A process has been developed for ...

439

Assessing digital control system dependability using the dynamic flowgraph methodology  

Energy Technology Data Exchange (ETDEWEB)

Dynamic Flowgraph Methodology (DFM) is a methodological approach to modeling and analyzing the behavior of software-driven embedded systems for the purpose of reliability/safety assessment and verification. The methodology has two fundamental goals: (a) to identify how certain postulated events may occur in a system and (b) to identify an appropriate testing strategy based on an analysis of system functional behavior. To achieve these goals, the methodology employs a modeling framework in which system models are developed in terms of causal relationships between physical variables and temporal characteristics of the execution of software modules. These models are then analyzed to determine how a certain state (desirable or undesirable) can be reached. This is done by developing timed fault trees, which take the form of logical combinations of static trees relating system parameters at different points in time. The prime implicants (multistate ...

1993-01-01

440

Americans' political participation in the 1993-94 national health care reform debate.  

Science.gov (United States)

The health politics and policy communities are still struggling with the question of "what went wrong" in the 1993-94 health care reform effort. Here I identify which Americans were politically active and inactive during the health care reform debate to explore the role political participation may have had in determining the outcome of the debate. Using data from a national and California random-sample telephone surveys, and controlling for other demographic attributes, I found that those who engaged in political activity specifically related to health care reform were disproportionately more likely to be self-identified conservatives, less likely to favor an employer mandate plan, more likely to be fifty to sixty-four years old, more likely to be men, and more likely to have greater interest in and knowledge of the health care issue. Even in California, where a single-payer proposal was on the November ballot, ...

1996-01-01

441

Adaptive PSS using a simple on-line identifier and linear pole-shift controller  

Energy Technology Data Exchange (ETDEWEB)

Implementation of an adaptive power system stabilizer (APSS) and experimental studies are presented in this paper. The APSS consists of an adaptive linear element (ADALINE) based identifier that identifies the power system as a third-order discrete auto-regressive moving average (ARMA) model and a pole-shift controller. The ADALINE is modeled so that its weights have a one-to-one relationship with the ARMA model parameters. The weights are updated at each sampling interval to track the dynamic characteristics of the actual system. The on-line updated ARMA parameters are used in the PS control algorithm to calculate the new closed-loop poles of the system that are always inside the unit circle in the z-plane. The calculated control is such that it achieves regulation of the system to a constant setpoint in the shortest interval of time. Experimental studies on a physical model of power system verify that the proposed adaptive PSS effectively ...

2010-04-15

442

Safe ageing management of nuclear power plants: An European synthesis  

International Nuclear Information System (INIS)

Ageing of nuclear power plants means evolution of material or equipment properties on one side, and evolution of personnel skill and procedure adequacy on the other side, both of which, after a certain time, may not be compatible with the required safety provisions, or with an economic operation of the plant. Repair or replacement of components, as well as change in service conditions for a better compatibility with component reduced capabilities can be used to mitigate ageing effects. The paper summarises the results of a study conducted in this field with the support of the European Commission. It presents: the synthesis of the work done under international auspices, and in the European context; the comparison of ageing management approaches used in several European countries with international recommendations; the summary of the various potential phenomena and their governing parameters, the methods of in-service ageing identification and possible mitigation methods; illustrative ...

2002-11-04

443

Working with activity theory: Context, technology, and information behavior  

British Library Electronic Table of Contents (United Kingdom)

Abstract Over the last 7 years, the AIMTech Research Group in the University of Leeds has used cultural-historical activity theory (CHAT) to inform a range of research activities in the fields of information behavior and information systems. In this article, we identify certain openings and theoretical challenges in the field of information behavior, which sparked our initial interest in CHAT: context, technology, and the link between practice and policy. We demonstrate the relevance of CHAT in studying information behavior and addressing the identified openings and argue that by providing a framework and hierarchy of activity-action-operation and semantic tools, CHAT is able to overcome many of the uncertainties concerning information behavior research. In particular, CHAT provides resear...

2011-01-01

444

Volcanoscope: Scoping study for increasing resilience to hazards in volcanic regions  

Environmental Research Database

ObjectivesProject VOLCANOSCOPE will evaluate strategies (1) for applying existing and new forecasting models to volcanic eruptions, and (2) for identifying methods to improve how forecasts are communicated effectively to vulnerable communities. To link forecasting and communication, the interdisciplinary study will assess how to engage all stakeholders - from monitoring scientists, through emergency agencies, to vulnerable communities - to optimize the understanding of forecasts among different end users. [continued...]DescriptionProject VOLCANOSCOPE will evaluate strategies (1) for applying existing and new forecasting models to volcanic eruptions, and (2) for identifying methods to improve how forecasts are communicated effectively to vulnerable communities. To link forecasting and communication, the interdisciplinary study will assess how to engage all stakeholders - from monitoring scientists, through emergency agencies, to vulnerable ...

2011-01-05

445

Transuranic radionuclides dispersed into the environment at accident sites, a bibliography  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this project was to compile a bibliography of references containing environmental transuranic radionuclide data. The authors intent was to identify those parameters affecting transuranic radionuclide transport that may be generic and those that may be dependent on chemical form and/or environmental conditions. An understanding of the unique characteristics and similarities between source terms and environmental conditions relative to transuranic radionuclide transport and cycling will provide the ability to assess and predict the long term impact on man and the environment. An additional goal of the literature review, was to extract the ranges of environmental transuranic radionuclide data from the identified references for inclusion in a data base. Related to source term, these ranges of data can be used to calculate the dose to man from the radionuclides, and to perform uncertainty analyses on these dose assessments.

1994-07-01

446

The hippo pathway in biological control and cancer development  

British Library Electronic Table of Contents (United Kingdom)

Abstract The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis. Deregulation of the Hippo pathway is linked to cancer development. Its first core kinase Warts was identified in Drosophila more than 15 years ago, but it gained much attention when other core components of the pathway were identified 8 years later. Major discoveries of the pathway were made during past several years. The core kinase components Hippo, Salvador, Warts, and Mats in the fly and Mst1/2, WW45, Lats1/2, and Mob1 in mammals phosphorylate and inactivate downstream transcriptional co-activators Yorkie in the fly, Yes-associated protein (YAP) and transcriptional co-activator with ...

2011-01-01

447

Terahertz time-domain spectroscopy of atmospheric water vapor from 0.4 to 2.7 THz.  

Energy Technology Data Exchange (ETDEWEB)

We conducted broadband absorption measurements of atmospheric water vapor in the ground state, X {sup 1}A{sub 1} (000), from 0.4 to 2.7 THz with a pressure broadening-limited resolution of 6.2 GHz using pulsed, terahertz time-domain spectroscopy (THz-TDS). We measured a total of seventy-two absorption lines and forty-nine lines were identified as H{sub 2}{sup 16}O resonances. All the H{sub 2}{sup 16}O lines identified were confirmed by comparing their center frequencies to experimental values available in the literature.

2005-10-01

448

Summary of research on microbiological processes. International Energy Agency Subtask D, final report  

Energy Technology Data Exchange (ETDEWEB)

Storage of thermal energy in aquifers has obvious benefits of saving energy and decreasing the consumption of fossil fuels. However, aquifer thermal energy storage (ATES), which involves groundwater aquifers as the storage medium for heat or chill, impinges on the environment. A literature review of pertinent microbiology publications (Hicks and Stewart, 1988) identified the potential for the interaction of ATES systems and microbiological processes to create a source of infectious diseases and the potential for damage to the environment. In addition, the review identified a potential for microbiological processes to develop conditions that would interfere with the operation of an ATES system. As a result of this research effort, investigators from Finland, Germany, Switzerland, and the United States have examined several ATES systems in operation and have observed that the ATES systems studied do not contribute to infectious disease ...

1992-09-01

449

Summary of research on microbiological processes  

Energy Technology Data Exchange (ETDEWEB)

Storage of thermal energy in aquifers has obvious benefits of saving energy and decreasing the consumption of fossil fuels. However, aquifer thermal energy storage (ATES), which involves groundwater aquifers as the storage medium for heat or chill, impinges on the environment. A literature review of pertinent microbiology publications (Hicks and Stewart, 1988) identified the potential for the interaction of ATES systems and microbiological processes to create a source of infectious diseases and the potential for damage to the environment. In addition, the review identified a potential for microbiological processes to develop conditions that would interfere with the operation of an ATES system. As a result of this research effort, investigators from Finland, Germany, Switzerland, and the United States have examined several ATES systems in operation and have observed that the ATES systems studied do not contribute to infectious disease ...

1992-09-01

450

Studies on the chemical composition and possible mechanisms underlying the antispasmodic and bronchodilatory activities of the essential oil of Artemisia maritima L.  

British Library Electronic Table of Contents (United Kingdom)

This study describes the chemical composition of the essential oil of Artemisia maritima (Am.Oil) and the pharmacological basis for its medicinal use in gut and airways disorders. Twenty five compounds, composing 93.7% of the oil, were identified; among these, chrysanthenyl propionate and elixene were identified for the first time from any Artemisia species. The Am.Oil (0.3?1.0 mg/mL) suppressed spontaneous and high K+ (80 mM)-induced contractions in isolated rabbit jejunum, suggestive of an antispasmodic effect mediated possibly through calcium channel blockade. The calcium channel blockade activity was confirmed when pre-treatment of the tissue with Am.Oil (0.01?0.03 mg/mL) shifted the Ca++ concentration-response curves to the right, similar to verapamil and papaverine. In isolated trach...

2011-01-01

451

String Universality in Six Dimensions  

CERN Document Server

In six dimensions, cancellation of gauge, gravitational, and mixed anomalies strongly constrains the set of quantum field theories which can be coupled consistently to gravity. We show that for some classes of six-dimensional supersymmetric gauge theories coupled to gravity, the anomaly cancellation conditions are equivalent to tadpole cancellation and other constraints on the matter content of heterotic/type I compactifications on K3. In these cases, all consistent 6D supergravity theories have a realization in string theory. We find one example which may arise from a novel string compactification, and we identify a new infinite family of models satisfying anomaly factorization. We find, however, that this infinite family of models, as well as other infinite families of models previously identified by Schwarz are pathological. We suggest that it may be feasible to demonstrate that there is a string theoretic realization of all consistent ...

2009-01-01

452

Slip and fatigue crack formation processes in an #alpha#/#beta# titanium alloy in relation to crystallographic texture on different scales  

International Nuclear Information System (INIS)

The purpose of this experimental study is to investigate the micromechanical fatigue behavior, in terms of slip nature and preferential cracking sites, of a commercial #alpha#/#beta#-forged Ti-6Al-4V alloy. Electron backscattering diffraction is extensively used to identify the deformation (prismatic, basal, pyramidal slip) and crack formation modes activated by fatigue at the surface of several hundred primary #alpha# nodules. Some fatal crack formation sites are also characterized. Cracking in basal planes is identified as the most critical damage mode leading to fracture. An explanation is proposed which involves the resolved shear stress, taking into account the Schmid factor and the normal stress in relation to the elastic anisotropy of the #alpha#-phase. Finally, the spatial distribution of the secondary cracks is analyzed according to the crystallographic textures (macrozones) present on a mesoscopic scale in the Ti-6Al-4V alloy.

2008-09-01

453

Sensitivity analysis: Interaction of DOE SNF and packaging materials  

International Nuclear Information System (INIS)

A sensitivity analysis was conducted to evaluate the technical issues pertaining to possible destructive interactions between spent nuclear fuels (SNFs) and the stainless steel canisters. When issues are identified through such an analysis, they provide the technical basis for answering what if questions and, if needed, for conducting additional analyses, testing, or other efforts to resolve them in order to base the licensing on solid technical grounds. The analysis reported herein systematically assessed the chemical and physical properties and the potential interactions of the materials that comprise typical US Department of Energy (DOE) SNFs and the stainless steel canisters in which they will be stored, transported, and placed in a geologic repository for final disposition. The primary focus in each step of the analysis was to identify any possible phenomena that could potentially compromise the structural integrity of the canisters and to ...

1999-06-06

454

Selective dissolution and recovery of depleted uranium from armor plate. Final report, 26 June 1986-5 May 1987  

Energy Technology Data Exchange (ETDEWEB)

The impacted armor targets used in testing high density armor-piercing ammunition containing depleted uranium (DU) are subject to disposal as low-level radioactive waste. Because of the costs associated with disposal of the entire armor plate and the limited use of secured commercial sites in the future, the U.S. Army is seeking to identify and evaluate new technologies for decontaminating these armor plates. The objectives of this Phase I SBIR program are two-fold, namely: to develop a selective solvent that can decontaminate impacted armor targets containing DU for disposal or recycle, and to identify and characterize technologies that can remove depleted uranium from the solvent for solvent recycle and uranium recovery for easier hazardous-waste disposal.

1987-05-05

455

Remedial investigation/feasibility study for the David Witherspoon, Inc., 901 Site, Knoxville, Tennessee: Volume 1  

Energy Technology Data Exchange (ETDEWEB)

This remedial investigation (RI)/feasibility study (FS) supports the selection of remedial actions for the David Witherspoon, Inc. 901 Maryville Pike Site in Knoxville, Tennessee. Operations at the site, used as a recycling center, have resulted in past, present, and potential future releases of hazardous substances in to the environment. This Site is a Tennessee Superfund site. A phased approach was planned to (1) gather existing data from previous investigations managed by the Tenn. Dept. of Environment and Conservation; (2) perform a preliminary RI, including risk assessments, and an FS with existing data to identify areas where remedial action may be necessary; (3) gather additional field data to adequately define the nature and extent of risk-based contaminants that present identifiable threats to human and/or ecological receptors; and (4) develop remedial action alternatives to reduce risks to acceptable levels.

1996-10-01

456

Proteomic analysis of apoptosis induction in human lung cancer cells by recombinant MVL  

British Library Electronic Table of Contents (United Kingdom)

Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic changes in A549 cells, and to identify the molecular pathways responsible for the anti-cancer action of R-MVL. We found that R-MVL induces A549 cells apoptosis in a dose-dependent manner by using MTT assay, fluorescent microscope (FM) and flow cytometry (FCM), and the IC50 was calculated to be 24.12??g/ml. Subsequently, 7 altered proteins in R-MVL-treated A549 cells were identified, including upregulated aldehyde dehydrogenase 1 and ?-actin, and five downregulated proteins: heat s...

2011-01-01

457

Proposals for the reporting of oil shale resources in Quennsland, Australia  

Energy Technology Data Exchange (ETDEWEB)

While no mine in Queensland has yet extracted shale oil economically, large resources of oil shale are known to occur throughout the State. These resources have been reported to the Queensland Department of Resource Industries (formerly the Department of Mines) according to a number of different parameters, using numerous methods of calculation and in some instances, detailed and comprehensive supporting information has not been provided. This paper outlines present methods of calculation and reporting of oil shale resources. A more uniform system of reporting resources of Queensland oil shale is desirable to enable an accountable and reliable estimate of resources to be made. It is intended that a code for the reporting of identified oil shale resources based on the present Australian codes for the reporting of identified mineral and coal resources be prepared, and that the importance of determining the level of confidence of resource ...

1990-09-01

458

Personal Information Databases  

CERN Document Server

One of the most important aspects of security organization is to establish a framework to identify security significant points where policies and procedures are declared. The (information) security infrastructure comprises entities, processes, and technology. All are participants in handling information, which is the item that needs to be protected. Privacy and security information technology is a critical and unmet need in the management of personal information. This paper proposes concepts and technologies for management of personal information. Two different types of information can be distinguished: personal information and nonpersonal information. Personal information can be either personal identifiable information (PII), or nonidentifiable information (NII). Security, policy, and technical requirements can be based on this distinction. At the conceptual level, PII is defined and formalized by propositions over infons (discrete pieces of ...

2009-01-01

459

Pectinolytic yeast isolates for cold-active polygalacturonase production  

British Library Electronic Table of Contents (United Kingdom)

Pectin rich cold stored spoiled fruits, vegetables and cold soils were screened and different pectinolytic isolates were obtained by enrichment culturing and ruthenium red plate assay. Among the primary isolates 10-15% were yeast isolates. Six isolates with higher zones of pectin hydrolysis were selected and tested for polygalacturonase (PGU) production at room temperature (25 degrees C) and at 5 degrees C. One isolate identified as Saccharomyces sp. with highest polygalacturonase activity at 5 degrees C was used for enzyme production using raw fruit pectins as substrates. The isolate was identified by preliminary cultural, morphological and sugar fermentation tests. PGU production was high in raw pectin substrates like orange peel (21 U/ml), apple peel (20 U/ml ), mango peel (19 U/ml), ...

2011-01-01

460

Moving train loads identification on a continuous steel truss girder by using dynamic displacement influence line method  

British Library Electronic Table of Contents (United Kingdom)

This paper presents a dynamic displacement influence line method for moving load identification on bridge. The finite element model of Poyang Lake continuous truss bridge-train systems is established and the dispersed modal shapes are acquired by modal analysis. Multi-axle moving train loads are identified with simulated annealing genetic algorithm by minimizing the errors between the measured displacements and the reconstructed displacements from the identified moving loads. In the identification process, the dynamic displacement influence line technique is used to calculate the time history displacement responses of the bridge to avoid solving equations of motion of the bridge repetitively. Several important parameters of the bridge-train system are discussed to investigate their effects...

2011-01-01

461

Moessbauer spectroscopic determination of chemical state of iron in bauxite  

International Nuclear Information System (INIS)

The chemical state of iron contained in several kinds of bauxite, which are utilized as a raw material in the aluminum industry in Japan, were investigated by Moessbauer spectroscopy. The main compounds of iron were identified from the results, which showed variations of the Moessbauer absorption spectra with calcination and measuring temperature. Although the absorption intensities of the spectra differed significantly, major species identified were paramagnetic or superparamagnetic #alpha#-Fe_2O_3 in all of these bauxite samples. The superparamagnetic #alpha#-Fe_2O_3 was found mainly in the gibbsite-type bauxite, but not in the boehmite/gibbsite-type or the boehmite-type bauxite. The Moessbauer absorption spectra of red mud and its calcined products were also given. (author).

462

Mineral-wool industry: opportunities for natural gas technologies. Topical report, January-July 1987  

Science.gov (United States)

To quantify the opportunities for natural gas and identify technological advances needed to capture such opportunities, the mineral-wool industry was analyzed with respect to the principal companies, their capabilities, and markets. The mineral-wool industry is stable with a slightly declining market. Of its market segments, only commercial acoustic insulation (which is currently dominant) is likely to be affected by growth in the next ten years. The principal process is based on treatment of blast-furnace slags in a cupola furnace using coke as the fuel and reducing agent. Expanded use of gas, as a substitute for coke, would eliminate environmental problems and expand the latitude of suitable raw materials. The study provides insights into the mineral-wool industry and identifies factors that may constitute bases for future usage of natural gas.

1988-05-01

463

Means for transferring knowledge in the relocation of manufacturing units  

DEFF Research Database (Denmark)

Based on case studies and action research, this paper investigates and discusses appropriate means for transfer knowledge when relocating manufacturing units. The cases include relocations both within the country and overseas. A framework for identifying suitable means is developed based on the situations which are extracted from the cases. Two parameters are used to classify the situation: the complexity of knowledge, and the environment for transferring the knowledge. Four different groups of means are identified from the case studies; 1) Documents or manuals and peer-to-peer training, 2) Scenarios on real systems, 3) Prototypes and games, and 4) Emulation. These means are evaluated based on the parameters in the framework and proper means are positioned in the framework. This framework can be used to support learning to develop knowledge in the new manufacturing unit.

2008-01-01

464

Materials for air turbines in wave power devices. A generic study  

Energy Technology Data Exchange (ETDEWEB)

Wave energy device teams have identified three varieties of air turbine as potentially applicable to wave energy devices. These are: conventional axial turbines; Wells, or self-rectifying, axial turbines and Francis turbines. This report examines the constructional requirements of these devices with regard to mechanical, environmental and manufacturing considerations. It is concluded that the major benefit of optimum material selection will be reduced manufacturing costs rather than enhanced turbine performance. A methodology of material selection has been established and candidate materials have been listed for the major components of each turbine type. Comparative costs for alternative materials are included, from which significant, potential economies have been identified. Recommendations are made aimed at achieving optimum material usage in the proposed turbines.

1981-01-01

465

Lebanon: assessment of the state of the environment.Final report  

International Nuclear Information System (INIS)

The study concerns the assessment of the state of the environment in Lebanon and the identification of policy options has three specific objectives namely to determine the conditions of the environment in Lebanon after years of wars (1975-1992); to identify environmentals trends associated with Lebanon's development and to assess their sustainability; to identify policy options for environmental management. Issues of the environment concerned are both the brown issues e.g. the management of wastes and effluent arising from human activitiesand green issues, the natural resource base defined through main receptors:air, water (including coastal waters), land and terrestrial ecology sectors such as agriculture, industry, energy, transport, tourism and fisheries, population and human settlements are also studied

466

LMBFR and LWR in-core thermal-hydraulic codes: the state-of-the-art and research and development needs  

Energy Technology Data Exchange (ETDEWEB)

A review of analytical design methods used for predicting reactor core flow and temperature distributions is presented with emphasis on LMFBR's. The paper also briefly describes and contrasts the methods used for LWR's. These methods are global analysis, subchannel analysis, distributed parameter, and hybrid analysis. The evolution of the local and subchannel analysis methods is presented. Data used for code validation are also presented. Current research and development needs are identified and discussed. Areas identified for future research and development include methods and expermental data for analysis of distorted bundles and natural convection. Methods that have been developed for predicting the safety performance of LMFBR's and LWR's are not within the scope of this paper.

1981-04-01

467

Knowledge-Based Identification of the ERK2/STAT3 Signal Pathway as a Therapeutic Target for Type 2 Diabetes and Drug Discovery  

British Library Electronic Table of Contents (United Kingdom)

Many existing agents for diabetes therapy are unable to restore or maintain normal glucose homeostasis or prevent the eventual emergence of hyperglycemia-related complication. Therefore, agents based on novel mechanisms are sought to complement and extend the current therapeutic approaches. Based on the initial paper research, we focused on active STAT3 as an attractive pharmacological target for type 2 diabetes. The subsequent text mining with a unique query to identify suppressors but not activators of STAT3 revealed the ERK2/STAT3 pathway as a novel diabetes target. The description of ERK2 inhibitors as diabetes target had not been found in our text mining research at present. The mechanism-based peptide inhibitor for ERK2 was identified using the knowledge of the KIM sequence, which ha...

2011-01-01

468

Isolation and mapping of a polymorphic DNA sequence (pEFD64. 2) on chromosome 3 (D3S46)  

Energy Technology Data Exchange (ETDEWEB)

A 4.0 kb TaqI fragment of cosmid EFD64 isolated by a HBV-3 oligonucleotide was subcloned into AccI site of pUC18. MspI identifies 5 allelic VNTR polymorphism with bands between 2.6 and 4.6 kb. RsaI, TaqI, EcoRI, BamHI, HindIII and PvuII identify the same VNTR polymorphism. With RsaI, 80% heterozygosity were observed in 80 unrelated Caucasians. This RFLP pEFD64.2 has been assigned to chromosome 3 by linkage analysis with loci (APOD) known to span this chromosome. Co-dominant segregation for the RsaI RFLP was observed in 40 three generation families. RFLPs were observed under the normal hybridization and washing condition.

1988-10-11

469

Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder  

British Library Electronic Table of Contents (United Kingdom)

Background Identifying susceptibility genes for endophenotypes by studying analogous behaviors across species is an important strategy for understanding the pathophysiology underlying psychiatric disorders. This approach provides novel biological pathways plus validated animal models critical for selective drug development. One such endophenotype is avoidance behavior. Methods In the present study, novel automated registration methods for longitudinal behavioral assessment in home cages are used to screen a panel of recently generated mouse chromosome substitution strains that are very powerful in quantitative trait loci (QTL) detection of complex traits. In this way, we identified chromosomes regulating avoidance behavior (increased sheltering preference) independent of motor activity lev...

2009-01-01

470

Identifying fade mechanisms in high-power lithium-ion cells.  

Energy Technology Data Exchange (ETDEWEB)

Hybrid electric vehicles (HEV) need long-lived high-power batteries as energy storage devices. Batteries based on lithium-ion technology can meet the high-power goals but have been unable to meet HEV calendar-life requirements. As part of the US Department of Energy's Advanced Technology Development (ATD) Program, diagnostic studies are being conducted on 18650-type lithium-ion cells that were subjected to accelerated aging tests at temperatures ranging from 40 to 70 C. This article summarizes data obtained by gas chromatography, liquid chromatography, electron microscopy, X-ray spectroscopy and electrochemical techniques, and identifies cell components that are responsible for the observed impedance rise and power fade.

2004-01-01

471

Identification of prostate cancer antigens by automated high-throughput filter immunoscreening  

British Library Electronic Table of Contents (United Kingdom)

There is a need for earlier and more accurate cancer diagnostics as well as new targets for cancer immunotherapy. To this end, it is important to identify sets of tumour antigens specific for different cancer forms. Several methods that identify potential tumour antigens in an arrayed and high-throughput format have been developed during the last years of SEREX (serological identification of antigens by recombinant expression cloning) related research. Such techniques may hold the potential to describe the complete immunogenic part of the cancer proteome, also called the cancer immunoproteome.We have developed a powerful platform for automated serological high-throughput filter screening of tumour cDNA libraries. The screening format of this method is 18,000 single cDNAs clones, which is s...

2008-01-01

472

High-Volume Centers  

British Library Electronic Table of Contents (United Kingdom)

Outcome from trauma, surgery, and a variety of other medical conditions has been shown to be positively affected by providing treatment at facilities experiencing a high volume of patients with those conditions. An electronic literature search was made to identify English-language articles available through March 2011, addressing the effect of patient treatment volume on outcome for patients with subarachnoid hemorrhage. Limited data were identified, with 16 citations included in the current review. Over 60% of hospitals fall into the lowest case-volume quartile. Outcome is influenced by patient volume, with better outcome occurring in high-volume centers treating >60 cases per year. Patients treated at low-volume hospitals are less likely to experience definitive treatment. Furthermore, t...

2011-01-01

473

Genomic survey of prepulse inhibition in mouse chromosome substitution strains  

British Library Electronic Table of Contents (United Kingdom)

Prepulse inhibition (PPI) is a measure of sensorimotor gating, a pre-attentional inhibitory brain mechanism that filters extraneous stimuli. Prepulse inhibition is correlated with measures of cognition and executive functioning, and is considered an endophenotype of schizophrenia and other psychiatric illnesses in which patients show PPI impairments. As a first step toward identifying genes that regulate PPI, we performed a quantitative trait locus (QTL) screen of PPI phenotypes in a panel of mouse chromosome substitution strains (CSSs). We identified five CSSs with altered PPI compared with the host C57BL/6J strain: CSS-4 exhibited decreased PPI, whereas CSS-10, -11, -16 and -Y exhibited higher PPI compared with C57BL/6J. These data indicate that A/J chromosomes 4, 10, 11, 16 and Y harbor...

2009-01-01

474

Genomic architecture of aggression: Rare copy number variants in intermittent explosive disorder  

British Library Electronic Table of Contents (United Kingdom)

Abstract Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of aggression in which individuals act impulsively and grossly out of proportion from the involved stressors. Previous studies have identified genetic variants in the serotonergic pathway that play a role in susceptibility to this behavior, but additional contributors have not been identified. Therefore, to further delineate possible genetic influences, we investigated CNVs in individuals diagnosed with IED and/or personality disorder (PD). We carried out array comparative genomic hybridizati...

2011-01-01

475

Gear fault identification and classification of singular value decomposition based on Hilbert-Huang transform  

British Library Electronic Table of Contents (United Kingdom)

An improved singular value decomposition method of gear fault identification based on Hilbert-Huang transform was proposed to overcome the problem of reconstructing a feature matrix of singular value decomposition. The method includes three steps. First, the instantaneous frequency and amplitude matrices were acquired by Hilbert-Huang transform from faulted gear signals. Second, after the matrices were decomposed by singular value decomposition, the defined distances of singular value vectors and the optimal threshold of the distance for classification were calculated. Third, the fault characteristics of a gearbox were identified and classified by the threshold of the distances. The result demonstrates that the proposed method effectively identifies the gear fault and can realize an automa...

2011-01-01

476

Gear crack level identification based on weighted K nearest neighbor classification algorithm  

British Library Electronic Table of Contents (United Kingdom)

A crack fault is one of the damage modes most frequently occurring in gears. Identifying different crack levels, especially for early cracks is a challenge in gear fault diagnosis. This paper aims to propose a method to classify the different levels of gear cracks automatically and reliably. In this method, feature parameters in time domain, specially designed for gear damage detection and in frequency domain are extracted to characterize the gear conditions. A two-stage feature selection and weighting technique (TFSWT) via Euclidean distance evaluation technique (EDET) is presented and adopted to select sensitive features and remove fault-unrelated features. A weighted K nearest neighbor (WKNN) classification algorithm is utilized to identify the gear crack levels. The gear crack experime...

2009-01-01

477

Explosives detector  

Energy Technology Data Exchange (ETDEWEB)

An apparatus for non-invasively inspecting an object, such as an item of luggage, for explosives material is described. It comprises a multi-channel thermal neutron inspection system having a plurality of neutron irradiation chambers. Simultaneous operation of several channels increases the maximum system throughput several times. Each chamber has a lithium neutron source which is stimulated to neutron production by a proton beam. Beam switching magnets are energised by pulsing to divert a common proton beam to each source in turn. The initial beam is generated by a radio frequency quadrupole accelerator. The advantages of this system are very low residual source activity and controllable neutron production thereby minimising safety hazards. The irradiation chamber may contain several different gamma ray detectors to identify the elements present in explosives material. In addition, a neutron radiography imaging means may be employed to ...

1991-10-02

478

Evaluation of Reports on Environmental Measurements of Electromagnetic Fields Generated by High Voltage Transmission Lines and Substations  

International Nuclear Information System (INIS)

This paper presents some situations, in which measurements of electromagnetic fields generated by transmission lines and substations should be performed. The range of measurements may differ, but maximum values of electric and magnetic fields and flux density must be identified in all situations. The area with electric field exceeding 1 kV/m should be identified as well. The author also presents basic requirements to be met by the measurement technique. These requirements are specified according to the national standard. Special attention should be paid to the identification of the spatial distribution of electric field and flux density generated in the vicinity of high voltage transmission lines. To verify the measurement results, it is necessary to calculate the distribution of both aforesaid field components. For environmental protection purposes, it is also proposed that the report should include measurements of electromagnetic fields of 50 ...

2007-01-01

479

Enhancing the Delivery of Supplemental Nutrition Assistance Program Education through Geographic Information Systems  

British Library Electronic Table of Contents (United Kingdom)

The Network for a Healthy California (Network) employs a Geographic Information System (GIS) to identify the target audience and plan program activities because GIS is a powerful tool for assisting in data integration and planning. This paper describes common uses of GIS by Network contractors as well as demonstrating the possibilities of GIS as a useful tool for public health programs and audience targeting in general. Narrative examples supported with graphics describe how 1) Network contractors use the GIS to identify eligible census tracts to carry out their work, 2) the GIS can map neighborhood assets in eligible census tracts throughout California, 3) the GIS can map health behavior data to the county level throughout California, and 4) the GIS can map selected indicators of healthy ...

2011-01-01

480

Energy savings opportunity survey. US Army Field Station Kunia, Oahu, Hawaii. Final report  

Science.gov (United States)

This Energy Savings Opportunity Survey (ESOS) is to identify Energy Conservation Opportunities (ECO`s) which are practical and economical for the reduction of energy consumption in accordance with the Army Facilities Energy Plan. The work to be performed under this project includes: (A) Coordinating with the on-going and proposed related projects. (B) Conducting a limited site survey required to identify applicable ECO`s and obtaining necessary data to evaluate the ECO`s. (C) Evaluating applicable ECO`s to determine their feasibility in accordance with current criteria. (D) Preparing programming and implementation documents for the recommended ECO`s. and (E) Preparing a comprehensive report to present the work performed including energy analysis, the results, and recommendations.

1989-06-01

481

Empirically defined subtypes of alcohol dependence in an Irish family sample  

British Library Electronic Table of Contents (United Kingdom)

Alcohol dependence (AD) is clinically and etiologically heterogeneous. The goal of this study was to explore AD subtypes among a sample of 1221 participants in the Irish Affected Sib Pair Study of Alcohol Dependence, all of whom met DSM-IV criteria for AD. Variables used to identify the subtypes included major depressive disorder, antisocial personality disorder, illicit drug dependence (cannabis, sedatives, stimulants, cocaine, opioids, and hallucinogens), nicotine dependence, the personality traits of neuroticism and novelty seeking, and early alcohol use. Using latent class analysis, a 3-class solution was identified as the most parsimonious description of the data. Individuals in a Mild class were least likely to have comorbid psychopathology, whereas a severe class had highest probabi...

2010-01-01

482

Dimensions and Latent Classes of Episodic Mania-Like Symptoms in Youth: An Empirical Enquiry  

British Library Electronic Table of Contents (United Kingdom)

The dramatic increase in diagnostic rates of bipolar disorder in children and adolescents in the USA has led to an intense interest in the phenomenology of the disorder. Here we present data from a newly-developed instrument to assess episodic mania-like symptoms in youth in a large population-based sample (N?=?5326) using parent- and self-report. We found that a substantial proportion of children screened positive for having episodes of ?going high? and were at an increased risk for morbidity and impairment. Using factor analysis, we identified that episodic mania-like symptoms comprised two dimensions: An under-controlled dimension that was associated with significant impairment, and a low-risk exuberant dimension. Using latent class analysis, we identified a small group of children scor...

2011-01-01

483

Development of tooling suitable for stall regulated blades  

Energy Technology Data Exchange (ETDEWEB)

The objectives of the project were to make significant improvements in the production of stall regulated blades in the areas of (a) the tip box, its housing, its mechanism and small GRP parts; (b) mould technology; (c) resins and glues and (d) root tooling. Although wood composite had been identified as a competitive technology for blades, compared with GRP blades, production volumes had been lower; reasons are given. The way in which the four areas identified for investigation were tackled are discussed. The study showed that the mould cycle time can be reduced to two days for a stall regulated blade and the blade quality can be improved by using the composite tip box and new resins. The time required for replication of moulds can be reduced by 40%.

2001-07-01

484

Detection of Visual Deficits in Aging DBA/2J Mice by Two Behavioral Assays  

British Library Electronic Table of Contents (United Kingdom)

Purpose: The DBA/2J mice have been used as an animal model for human pigmentary glaucoma. However, these mice develop various degrees of disease symptoms at different ages, making it difficult to detect pathological changes of retinal degeneration at glaucoma onset. The purpose of this study is to develop a non-invasive assay to identify individual mice that develop visual deficits. Materials and Methods: We apply two behavioral tests, a swimming test of visual discrimination and a test of optomotor response, to identify glaucomatous DBA/2J mice. We then examine whether the elevation of intraocular pressure (IOP), the common risk factor for glaucoma, affects visual performances of the DBA/2J mice. We further compare the retinal ganglion cell death, one of the signature glaucoma symptoms, i...

2011-01-01

485

Defining the research agenda to reduce the joint burden of disease from Diabetes mellitus and Tuberculosis  

British Library Electronic Table of Contents (United Kingdom)

Summary The steadily growing epidemic of diabetes mellitus poses a threat for global tuberculosis (TB) control. Previous studies have identified an important association between diabetes mellitus and TB. However, these studies have limitations: very few were carried out in low-income countries, with none in Africa, raising uncertainty about the strength of the diabetes mellitus-TB association in these settings, and many critical questions remain unanswered. An expert meeting was held in November 2009 to discuss where there was sufficient evidence to make firm recommendations about joint management of both diseases, to address research gaps and to develop a research agenda. Ten key research questions were identified, of which 4 were selected as high priority: (i) whether, when and how to sc...

2010-01-01

486

Data summary of municipal solid waste management alternatives  

Energy Technology Data Exchange (ETDEWEB)

The overall objective of the study in this report was to gather data on waste management technologies to allow comparison of various alternatives for managing municipal solid waste (MSW). The specific objectives of the study were to: 1. Compile detailed data for existing waste management technologies on costs, environmental releases, energy requirements and production, and coproducts such as recycled materials and compost. Identify missing information necessary to make energy, economic, and environmental comparisons of various MSW management technologies, and define needed research that could enhance the usefulness of the technology. 3. Develop a data base that can be used to identify the technology that best meets specific criteria defined by a user of the data base. Volume I contains the report text. Volume II contains supporting exhibits. Volumes III through X are appendices, each addressing a specific MSW management technology. Volumes XI ...

1992-10-01

487

Cosmic ray antiproton/electron discrimination capability of the CAPRICE silicon-tungsten calorimeter using neural networks  

Energy Technology Data Exchange (ETDEWEB)

A data analysis based on an artificial neural network classifier is proposed to identify cosmic ray antiprotons detected with the CAPRICE silicon-tungsten imaging calorimeter against electron background in the energy range 1.2-4.0 GeV. A set of new physical variables, describing the events inside the calorimeter on the base of their different patterns, are introduced in order to discriminate between hadronic and electromagnetic showers. The ability of the artificial neural network classifier to perform a careful multidimensional analysis gives the possibility to identify antiprotons with an electron rejection 408{+-}85 (stat) at 95.0{+-}0.2 (stat)% of signal detection efficiency. The high accuracy achieved by this method improves substantially the efficiency in the evaluation of the cosmic ray antiproton spectrum. (orig.).

1996-11-01

488

Corrective measures evaluation work plan Technical Area V groundwater.  

Energy Technology Data Exchange (ETDEWEB)

This document, which is prepared as directed by the Compliance Order on Consent (COOC) issued by the New Mexico Environment Department, identifies and outlines a process to evaluate remedial alternatives to identify a corrective measure for the Sandia National Laboratories New Mexico Technical Area (TA)-V Groundwater. The COOC provides guidance for implementation of a Corrective Measures Evaluation (CME) for the TA-V Groundwater. This Work Plan documents an initial screening of remedial technologies and presents a list of possible remedial alternatives for those technologies that passed the screening. This Work Plan outlines the methods for evaluating these remedial alternatives and describes possible site-specific evaluation activities necessary to estimate remedy effectiveness and cost. These methods will be reported in the CME Report. This Work Plan outlines the CME Report, including key components and a description of the corrective ...

2004-04-01

489

Corrective measures evaluation work plan : Technical Area V Groundwater : revision 0.  

Energy Technology Data Exchange (ETDEWEB)

This document, which is prepared as directed by the Compliance Order on Consent (COOC) issued by the New Mexico Environment Department, identifies and outlines a process to evaluate remedial alternatives to identify a corrective measure for the Sandia National Laboratories/New Mexico Technical Area (TA)-V Groundwater. The COOC provides guidance for implementation of a Corrective Measures Evaluation (CME) for the TA-V Groundwater. This Work Plan documents an initial screening of remedial technologies and presents a list of possible remedial alternatives for those technologies that passed the screening. This Work Plan outlines the methods for evaluating these remedial alternatives and describes possible site-specific evaluation activities necessary to estimate remedy effectiveness and cost. These methods will be reported in the CME Report. This Work Plan outlines the CME Report, including key components and a description of the corrective ...

2004-12-01

490

Code Verification by the Method of Manufactured Solutions  

Energy Technology Data Exchange (ETDEWEB)

A procedure for code Verification by the Method of Manufactured Solutions (MMS) is presented. Although the procedure requires a certain amount of creativity and skill, we show that MMS can be applied to a variety of engineering codes which numerically solve partial differential equations. This is illustrated by detailed examples from computational fluid dynamics. The strength of the MMS procedure is that it can identify any coding mistake that affects the order-of-accuracy of the numerical method. A set of examples which use a blind-test protocol demonstrates the kinds of coding mistakes that can (and cannot) be exposed via the MMS code Verification procedure. The principle advantage of the MMS procedure over traditional methods of code Verification is that code capabilities are tested in full generality. The procedure thus results in a high degree of confidence that all coding mistakes which prevent the equations from being solved correctly have been ...

2000-06-01

491

Body-and-cad Geometric Constraint Systems  

CERN Document Server

Motivated by constraint-based CAD software, we develop the foundation for the rigidity theory of a very general model: the body-and-cad structure, composed of rigid bodies in 3D constrained by pairwise coincidence, angular and distance constraints. We identify 21 relevant geometric constraints and develop the corresponding infinitesimal rigidity theory for these structures. The classical body-and-bar rigidity model can be viewed as a body-and-cad structure that uses only one constraint from this new class. As a consequence, we identify a new, necessary, but not sufficient, counting condition for minimal rigidity of body-and-cad structures: nested sparsity. This is a slight generalization of the well-known sparsity condition of Maxwell.

2010-01-01

492

Body mass index and risk of colorectal cancer in Chinese Singaporeans  

British Library Electronic Table of Contents (United Kingdom)

AbstractBACKGROUND: The authors chose to examine the association between body mass index (BMI) and incident colorectal cancer across the spectrum of BMI, including underweight persons, because detailed prospective cohort data on this topic in Asians is scarce, as is data on underweight persons (BMI, <18.5 kg/m2) in any population. METHODS: Analysis of the Singapore Chinese Health Study included 51,251 men and women aged 45-74 years enrolled in 1993-1998 and followed through 2007. Incident cancer cases and deaths among cohort members were identified through record linkage, and 980 cases were identified. Cox regression models were used to investigate the association of baseline BMI with risk of incident colorectal cancer during a mean of 11.5 years of follow-up. RESULTS: A significant, U-sha...

2011-01-01

493

An analysis of tanker-based floating production systems for small offshore fields  

Energy Technology Data Exchange (ETDEWEB)

A historical review of floating production storage and offloading (FPSO) systems for marginal fields is presented. The areas in which such systems are operating, ranges of model tests, and current applicability of mooring systems are reviewed to present capabilities of these concepts. Limitations are reviewed to assess the applicability of these concepts to similar sites. Consideration of processing operations on floating vessels are identified. Particularly, the effects of vessel motion on the processing equipment, gas disposal, and crude offloading are addressed. It will be shown that operations are becoming well understood and routine. Future problem areas and solutions under development are identified. Specific examples are cited and design refinements are noted. While various floating production systems have been in operation for only a few years, their potential for solving the problems of producing small offshore fields and for achieving ...

1982-08-01

494

Activation of a multisensory, multifunctional nucleus in the zebrafish midbrain during diverse locomotor behaviors  

British Library Electronic Table of Contents (United Kingdom)

Action potentials from the brain control the activity of spinal neural networks to produce, by as yet unknown mechanisms, a variety of motor behaviors. Particularly lacking are details on how identified descending neurons integrate diverse sensory inputs to generate specific locomotor patterns. We have examined the operations of the principal neurons in an intriguing midbrain nucleus, the nucleus of the medial longitudinal fasciculus (nMLF), in the larval zebrafish. The nMLF is the most rostral grouping of neurons that projects from the brain well into the spinal cord of teleost fishes, yet there is little direct physiological data available regarding its function. We report here that a distinct set of large, individually-identifiable neurons in nMLF (the MeL and MeM neurons) are activated...

2010-01-01

495

A single-institution review of 157 patients presenting with benign and malignant tumors of the ampulla of Vater: Management and outcomes  

British Library Electronic Table of Contents (United Kingdom)

BackgroundAlthough benign ampullary tumors are removed endoscopically, due to their potential to progress to malignant disease, the favored treatment for adenocarcinoma is pancreaticoduodenectomy. We reviewed our institutions experience in order to identify which patients were at highest risk of disease progression following surgical resection, as well as evaluate whether localized T1 tumors are best treated by pancreaticoduodenectomy. MethodsWe retrospectively reviewed 157 patients who presented with an ampullary mass, from 2001 to 2010, and identified 51 with benign adenoma and 106 with adenocarcinoma. ResultsPatients with malignant tumors most often presented with larger tumors and jaundice, which alone was predictive of survival (OR = 67). Forty-five percent of patients with pathologic...

2011-01-01

496

A novel wavelet transform aided neural network based transmission line fault analysis method  

Energy Technology Data Exchange (ETDEWEB)

In the present scenario of market driven business, power supply has become more like a commodity. Reliable and quality power need to be ensured to meet customer requirements. In such a situation, it is extremely important that transmission line faults be identified accurately, reliably and in quick time. Advanced signal processing tools such as discrete wavelet transform (DWT) can be used very effectively for parameterisation and characterization of the fault signals. On the other hand, properly configured neural network (NN) can be utilized for classification of the faults based on the DWT signal. The present contribution uses electromagnetic transient program (EMTP) for modeling of a real transmission system and MATLAB for DWT and NN. Various types of faults have been simulated at different locations along the transmission line and an attempt has been made to correctly identify and locate the fault. (author)

2009-06-15

497

A new approach to the isolation and characterization of wheat flour allergens  

British Library Electronic Table of Contents (United Kingdom)

Summary Background The incidence of food allergy to wheat is increasing. Its diagnosis depends on the purity of major allergens and their inclusion in tests. Isolation and characterization of wheat allergens are therefore of utmost importance. Objective To purify and identify wheat flour allergens most frequently recognized by patients' IgE antibodies and to study their allergenicity. Methods Water/salt-soluble extracts from wheat flour were prepared and separated using a combination of ultrafiltration, isoelectric focusing and liquid chromatography. Purified proteins were analysed by immunoblotting using pooled sera from patients with atopic dermatitis who possessed IgE specific to wheat. Wheat proteins found to bind IgE were subsequently identified by matrix-assisted laser desorption/ion...

2011-01-01

498

A neuro power system stabilizer based on adaptive control technique  

Energy Technology Data Exchange (ETDEWEB)

A power system stabilizer based on GMV (Generalized Minimum Variance), one of the adaptive control techniques, is developed to enhance the dynamic performances of a power system using an Artificial Neural Network (ANN). The stabilizer consists of two parts. One part is Inverse Dynamics Neural Networks (IDNN), which is trained to identify the inverse dynamics of controlled plant and used as a one-step ahead controller, or inverse controller. The other part is Adaptive Reference Model (ARM), which prevents excessive controller output. The ARM produces the modified reference value by minimizing a cost function recursively on the assumption that the IDNN perfectly identifies the controlled plant. The IDNN is used in the minimization procedure to calculate the sensitivities. The proposed controller is simulated in a typical one-machine-infinite-bus power system to show its effectiveness to damp sustained low frequency oscillation. (author)

1996-12-31

499

A multidimensional hybrid intelligent method for gear fault diagnosis  

British Library Electronic Table of Contents (United Kingdom)

Identifying gear damage categories, especially for early faults and combined faults, is a challenging task in gear fault diagnosis. This paper proposes a new multidimensional hybrid intelligent diagnosis method to identify different categories and levels of gear damage automatically. In this method, Hilbert transform, wavelet packet transform (WPT) and empirical mode decomposition (EMD) are performed on gear vibration signals to extract additional fault characteristic information. Then, multidimensional feature sets including time-domain, frequency-domain and time-frequency-domain features are generated to reveal gear health conditions. Multiple classifiers based on several classification algorithms and input features are combined with genetic algorithm (GA). Because of the use of multidim...

2010-01-01