An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
UK PubMed Central (United Kingdom)
Cancers are highly heterogeneous and contain many passenger and driver mutations. To functionally identify tumor suppressor genes relevant to human cancer, we compiled pools of short harpin...Full Text Available
2008-11-28
Predicting the efficiency of activated charcoal for filtering radon
Energy Technology Data Exchange (ETDEWEB)
In order to accurately assess the effectiveness of activated charcoal for the removal of radon from flowing air, a literature survey was performed to identify the models and relevant data that were available. It was found that by modifying the mathematical model of equilibrium stage theory used by Strong and Levins, the output rate of an activated charcoal filter exposed to a step function input in the radon rate at time zero with a given carrier gas flow velocity could be predicted. This paper outlines the modifications made to Strong and Levins's model and presents predictions for the filter output from the modified model.
1993-01-01
Identification and Functional Relevance of de novo DNA Methylation in Cancerous B-Cell Populations
UK PubMed Central (United Kingdom)
Epigenetic remodeling is a hallmark of cancer, with the frequent acquisition of de novo DNA methylation in CpG islands. However, the functional relevance of de novo...Full Text Available
2010-03-01
On the temperature dependence of the magnetic excitations
International Nuclear Information System (INIS)
We compare experimental data for temperature dependence of the magnetic order parameter and the magnetic excitations (spin waves) in materials with a quenched orbital moment and a well-defined spin quantum number. It is observed that the thermal decrease of the two quantities proceeds according to the same analytical function of the type y(T)=1-cT"#epsilon# with an identical exponent #epsilon#. This power function applies not only asymptotically for T->0 but holds over a wide temperature range. The exponent #epsilon# is universal, i.e. independent of spin order type and lattice symmetry and depends only on the dimensionality of the relevant interactions and on whether the spin quantum number is integer or half-integer. The different T"#epsilon# functions are identified as representations of stable universality classes. The fact that order parameter and magnetic excitations follow ...
2005-07-15
International Nuclear Information System (INIS)
The International Atomic Energy Agency has initiated a co-ordinated research programme on implementation of base-isolation for nuclear structures. This paper discusses two areas relevant to modelling elastomeric base-isolators. These are the use of simplified models to predict the response of isolated structures to earthquake inputs and finite element analysis for calculating the stress distributions within the isolators. In the former, a curvilinear hysteretic model of the high damping natural rubber able to accommodate the stiffening of the rubber at large shear deflections is presented. Its predictions of structural accelerations and bearing displacement produced by design earthquakes and those above the design level are compared with those using a linear spring and dashpot model. A comparison has been made between two finite element analyses using MARC and ABAQUS of the force-deformation behaviour of a single disc of rubber bonded on both sides. The disc was ...
1996-05-27
Aripiprazole augmentation in poor insight obsessive-compulsive disorder: a case report
UK PubMed Central (United Kingdom)
BackgroundObsessive-compulsive disorder is associated with a relevant impairment in social and interpersonal functioning and severe disability. This seems to be particularly true...Full Text Available
Energy Technology Data Exchange (ETDEWEB)
After reviewing some of the mathematical foundations and numerical difficulties facing lattice QCD, I review the status of several calculations relevant to experimental high-energy physics. The topics considered are moments of structure functions, which may prove relevant to search for new phenomena at the LHC, and several aspects of flavor physics, which are relevant to understanding CP and flavor violation.
2002-09-30
The Differentially Expressed Genes by Radiotherapy in the Patients with Uterine Cervix Cancer
Energy Technology Data Exchange (ETDEWEB)
Purpose : To detect differentially expressed genes in the patients with uterine cervical cancer during the radiation therapy. Materials and Methods : In patients with biopsy proven uterine cervical cancer, we took a tumor tissue just before radiation therapy and at 40 minutes after external irradiation of 1.8 Gy. Total RNAs isolated from non-irradiated and irradiated tumor tissue samples were analyzed using the differential-display reverse transcription-polymerase chain reaction (DDRT-PCR). Complementary DNA (cDNA) fragments corresponding to differentially expressed messenger RNAs(mRNAs) were eluted, and cloned. The differential expression of the corresponding mRNAs was confirmed by reverse northern blot. Differentially expressed cDNA bands were sequenced. Nucleotide sequence data were analyzed in the Gene Bank and EMBL databases via the BLAST network server to identify homologies to known genes or cDNA fragments. Expression pattern of down-regulated clone was ...
2001-12-15
PURPOSE: Hepatocellular carcinoma (HCC) is a highly virulent malignancy with no effective treatment thus requiring innovative and effective targeted therapies. The oncogene Astrocyte elevated gene-1 (AEG-1) plays a seminal role in hepatocarcinogenesis and profoundly downregulates insulin-like growth factor binding protein-7 (IGFBP7). The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the relevance of IGFBP7 downregulation in mediating AEG-1 function.EXPERIMENTAL DESIGN: IGFBP7 expression was detected by immunohistochemistry in HCC tissue microarray and real-time PCR and ELISA in human HCC cell lines. Dual Fluorescence in situ hybridization was performed to detect loss of heterozygosity at IGFBP7 locus. Stable IGFBP7-overexpressing clones were established in the background of AEG-1-overexpressing human HCC cells and were analyzed for in vitro proliferation and senescence and in ...
2011-09-16
UK PubMed Central (United Kingdom)
This paper summarizes the deliberations of a work group charged with addressing specific questions relevant to risk estimation in developmental neurotoxicology. We focused on eight questions. a) Does...Full Text Available
2000-06-01
High spin states of some nuclei around the N=Z=28 double closed shell
Energy Technology Data Exchange (ETDEWEB)
A spectroscopic study is performed for high spin states of {sup 55}Fe, {sup 55}Co and {sup 57}Ni. To populate the investigated residues with a relevant cross section, the fusion evaporation reactions of {sup 30}Si({sup 28}Si, 2pn){sup 55}Fe, {sup 30}Si({sup 28}Si, 2pn){sup 55}Co and {sup 4}He({sup 54}Fe, n){sup 57}Ni were chosen. To identify the new {gamma} transitions and to build the energy level schemes, {gamma}-{gamma} coincidence techniques together with excitation functions were employed. Angular distributions and {gamma}-{gamma} angular correlations allowed us to assign the spin values of the nuclear states. The previous level scheme of {sup 55}Fe is extended into the region between 6.5-11 MeV of excitation energy, up to spin 27/2, while the yrast decay pathos of {sup 57}Ni and {sup 55}Co are reported here for the first time. Experimental data are fairly well reproduced by Glaudemans' shell model ...
1989-12-01
High spin states of some nuclei around the N=Z=28 double closed shell
International Nuclear Information System (INIS)
A spectroscopic study is performed for high spin states of "5"5Fe, "5"5Co and "5"7Ni. To populate the investigated residues with a relevant cross section, the fusion evaporation reactions of "3"0Si("2"8Si, 2pn)"5"5Fe, "3"0Si("2"8Si, 2pn)"5"5Co and "4He("5"4Fe, n)"5"7Ni were chosen. To identify the new #gamma# transitions and to build the energy level schemes, #gamma#-#gamma# coincidence techniques together with excitation functions were employed. Angular distributions and #gamma#-#gamma# angular correlations allowed us to assign the spin values of the nuclear states. The previous level scheme of "5"5Fe is extended into the region between 6.5-11 MeV of excitation energy, up to spin 27/2, while the yrast decay pathos of "5"7Ni and "5"5Co are reported here for the first time. Experimental data are fairly well reproduced by Glaudemans' shell model calculations. (orig.).
1989-01-01
Energy Technology Data Exchange (ETDEWEB)
Safety standards for exposure to radiofrequency radiation must be based upon biologic consequences of exposure to such environments. Behavioral-based measures are considered to be the most-sensitive indices of biological effects. Current safety guidelines are based upon average power density and may not be relevant to the high-peak-power, short pulse width microwave radiation produced by newly developed high peak power microwave sources. The effects of exposure to high-peak-power radiation on reflexive responding and motor function in Fischer 344/N rats were assessed by measuring startle and general activity, and disruption of on-going performance of a rotarod task, respectively. The emitter used was the TEMPO repeat pulse axially extracted vircator. Exposure to single pulses resulted in significant startle responses. Exposure to 1 pps for 10 s produced significant alterations in baseline activity and marked disruption of performance of the ...
1988-03-01
Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis
UK PubMed Central (United Kingdom)
E-cadherin is the primary cell adhesion molecule within the epithelium, and loss of this protein is associated with a more aggressive tumour phenotype and poorer patient prognosis in many cancers. Loss...Full Text Available
2011-01-01
Abnormal Brain Default-Mode Network Functional Connectivity in Drug Addicts
UK PubMed Central (United Kingdom)
BackgroundThe default mode network (DMN) is a set of brain regions that exhibit synchronized low frequency oscillations at resting-state, and is believed to be relevant to attention...Full Text Available
Energy Technology Data Exchange (ETDEWEB)
Human senescence marker protein 30 (SMP30), which functions enzymatically as a lactonase, hydrolyzes various carbohydrate lactones. The penultimate step in vitamin-C biosynthesis is catalyzed by this enzyme in nonprimate mammals. It has also been implicated as an organophosphate hydrolase, with the ability to hydrolyze diisopropyl phosphofluoridate and other nerve agents. SMP30 was originally identified as an aging marker protein, whose expression decreased androgen independently in aging cells. SMP30 is also referred to as regucalcin and has been suggested to have functions in calcium homeostasis. The crystal structure of the human enzyme has been solved from X-ray diffraction data collected to a resolution of 1.4 {angstrom}. The protein has a 6-bladed {beta}-propeller fold, and it contains a single metal ion. Crystal structures have been solved with the metal site bound with either a Ca{sup 2+} or a Zn{sup 2+} atom. The ...
2010-05-25
Automatic computation of three-loop two-point functions in large momentum expansion
International Nuclear Information System (INIS)
We discuss the calculation of two-point three-loop functions with an arbitrary number of massive propagators and one large external momentum. The relevant subdiagrams are generated automatically. The resulting massless two-point integrals and massive tadpoles are transformed on-line to FORM-expressions ready to be used by existing FORM packages which calculate them analytically. As an example we compute the quartic mass corrections to the photon polarization function. (orig.).
The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses.
Schizophrenia and bipolar disorder share genetic risk, brain vulnerability, and clinical symptoms. The ZNF804A risk variant, rs1344706, confers susceptibility for both disorders. This study aimed to identify neural mechanisms common to both schizophrenia and bipolar disorder through this variant's potential effects on cortical thickness, white matter tract integrity, and cognitive function. Imaging, genetics, and cognitive measures were ascertained in 62 healthy adults aged between 18 and 59 years. High-resolution multimodal MRI/DTI imaging was used to measure cortical thickness and major frontotemporal and interhemispheric white matter tracts. The general linear model was used to examine the influence of the ZNF804A rs1344706 risk variant on cortical thickness, white matter tract integrity, and cognitive measures. Individuals homozygous for the risk variant ('A' allele) demonstrated reduced cortical gray matter thickness in the superior ...
2011-04-27
The epidermal compartment is complex and organized into several strata composed of keratinocytes (KCs), including basal, spinous, granular, and cornified layers. The continuous process of self-renewal and barrier formation is dependent on a homeostatic balance achieved amongst KCs involving proliferation, differentiation, and cell death. To determine genes responsible for initiating and maintaining a cornified epidermis, organotypic cultures comprised entirely of stratified KCs creating epidermal equivalents (EE) were raised from a submerged state to an air/liquid (A/L) interface. Compared to the array profile of submerged cultures containing KCs predominantly in a proliferative (relatively undifferentiated) state, EEs raised to an A/L interface displayed a remarkably consistent and distinct profile of mRNAs. Cultures lifted to an A/L interface triggered the induction of gene groups that regulate proliferation, differentiation, and cell death. Next, differentially expressed microRNAs ...
2010-05-25
International Nuclear Information System (INIS)
Time-odd parton distribution functions in a Drell-Yan process are here studied by examining the evolution of the internal statistical properties of the interacting hadrons. Time-odd functions are shown to be a signature of the irreversible process in which a hadronic state characterized by long range correlation properties (hadronic phase) decays to produce a cloud of independent partons (partonic phase) because of initial/final state interactions. The relevant considered variable is the rate of increase of the entropy of the hadronic system. This quantity is shown to be roughly equal to the decay rate of the hadronic state. Conditions for getting a leading twist time-odd effect are established on this basis. Last, the relevant case of a large entropy increase associated with transverse-dominated initial/final state interactions is analyzed.
2007-04-01
Physiologic changes during growth and development.
UK PubMed Central (United Kingdom)
To express growth-related changes in physiologic or other functions in forms usable for kinetic modeling, we are interested in identifying regular relationships that take the form of simple mathematical...Full Text Available
1994-12-01
Opportunities for coal liquefaction research in British Columbia
Energy Technology Data Exchange (ETDEWEB)
This paper presents the results of a study commissioned by the British Columbia Science Council to identify opportunities for liquefaction of B.C. coals and to recommend effective approaches to the development of a research program on coal conversion. Contains reviews of British Columbia coal resources to identify prospective candidates for conversion to liquid fuels; of the state of the art in the various processes for the conversion of coal to liquid fuels with particular emphasis on those processes most relevant to British Columbia applications; and of research opportunities in British Columbia for the development of coal liquefaction technology. (16 refs.)
1980-05-01
Effect of the size of an artificial neural network used as pattern identifier
Energy Technology Data Exchange (ETDEWEB)
A novel way to extract relevant parameters associated with the outgoing ions from nuclear reactions, obtained by digitizing the signals provided by a Bragg curve spectrometer (BCS) is presented. This allowed the implementation of a more thorough pulse-shape analysis. Due to the complexity of this task, it was required to take advantage of new and more powerful computational paradigms. This was fulfilled using a back-propagation artificial neural network (ANN) as a pattern identifier. Over training of ANNs is a common problem during the training stage. In the performance of the ANN there is a compromise between its size and the size of the training set. Here, this effect will be illustrated in relation to the problem of Bragg Curve (BC) identification. (Author)
2003-07-01
Expression and purification of a functional human hepatitis B virus polymerase
UK PubMed Central (United Kingdom)
AIM: To identify a method for efficient large-scale purification of functional hepatitis B virus polymerase (HBV-Pol) without addition of cellular factors.METHODS: Full-length HBV-Pol (843 amino...Full Text Available
2010-12-07
Application of neural networks to pulse-shape analysis of Bragg curves
Energy Technology Data Exchange (ETDEWEB)
A novel approach is presented to extract relevant parameters associated with the energy loss of ejectiles from nuclear reactions obtained by digitizing the signals of a Bragg curve spectrometer. New and more powerful computational paradigms allow a more thorough pulse-shape analysis. This is fulfilled using a back-propagation artificial neural network as a pattern identifier. The known problem of over-training is discussed.
2006-01-15
New procedures. Comprehensive staging of lung cancer by MRI
International Nuclear Information System (INIS)
Lung cancer staging according to the TNM system is based on morphological assessment of the primary cancer, lymph nodes and metastases. All aspects of this important oncological classification are measurable with MRI. Pulmonary nodules can be detected at the clinically relevant size of 4-5 mm in diameter. The extent of mediastinal, hilar and supraclavicular lymph node affection can be assessed at the same time. The predominant metastatic spread to the adrenal glands and spine can be detected in coronal orientation during dedicated MRI of the lungs. Search focused whole body MRI completes the staging. Various additional MR imaging techniques provide further functional and clinically relevant information during a single examination. In the oncological context the most important techniques are imaging of perfusion and tumor motion. Functional MRI of the lungs complements the pure staging and improves ...
2010-08-01
Energy Technology Data Exchange (ETDEWEB)
In 1998, EU legislation initiated a liberalisation process among European energy markets. The process of market opening has significantly changed the functioning of the markets and the competition conditions of the energy sector. At the same time, the industry witnessed a surge of mergers and far-reaching changes in the structure of German electricity and natural gas markets occurred. Against this background, the doctoral thesis at hand surveys the merger activities in the energy sector as well as the merger control policy of the German Federal Cartel Office during the first years of liberalisation. The study starts with a portrayal of the institutional framework of the German merger control regime and a survey of the relevant economic literature on horizontal and vertical mergers. Subsequent to the legal and theoretical considerations, the merger activities and the merger control policy of the German Federal Cartel Office are investigated ...
2008-11-06
MEG studies of human vision: Retinotopic organization of V1
Energy Technology Data Exchange (ETDEWEB)
A primary goal of noninvasive studies of human vision is to identify and characterize multiple visual areas in the human brain analogous to those identified in studies of nonhuman primates. By combining functional MEG measurements with images of individual anatomy derived from MRI, the authors hope to determine the location and arrangement of multiple visual areas in human cortex and to probe their functional significance. The authors have identified several different visual areas thus far which appear to be topographically organized. This paper focuses on the retinotopic characterization of the primary visual area (V1) in humans.
1993-12-31
Lack of awareness of symptoms in people with dementia: the structural and functional basis
British Library Electronic Table of Contents (United Kingdom)
AbstractObjective To review studies investigating the brain correlates of unawareness of cognitive and behavioural symptoms in people with dementia. Design A detailed search of the literature was conducted to include all the peer-reviewed studies published in English aimed at identifying the structural or functional brain correspondents of unawareness in dementia patients. Their results were interpreted in relation to the methodological differences in terms of type of dementia studied, the protocol adopted to measure lack of awareness, the imaging techniques employed, the experimental designs and statistical analyses performed. Results Eighteen studies undertaken to explore the functional and structural correlates of unawareness of cognitive symptoms in dementia were identified. Although t...
2011-01-01
International Nuclear Information System (INIS)
In Daya Bay and Ling'ao Nuclear Power Station, the Microgovernor has the control functions such as synchronization, block loading etc. The control principle of the Microgovernor is right described by sequence diagram for the first time. That the fault occurred in the synchronization process of Daya Bay Nuclear Power Station unit 1 is also analyzed and illustrated. (author)
2005-09-01
Static-static-light-light tetraquarks in lattice QCD
I report on a lattice computation of the energy of a system of two light quarks and two static antiquarks as a function of the separation of the static antiquarks. In terms of hadrons such a system corresponds to a pair of B mesons and its energy to the hadronic potential. I present selected results for different isospin, spin and parity combinations of the individual B mesons mainly focusing on those channels relevant to determine, whether two B mesons may form a bound tetraquark state.
2011-01-01
Computing Networks: A General Framework to Contrast Neural and Swarm Architectures
Computing Networks (CNs) are defined. These are used to generalize neural and swarm architectures, namely artificial neural networks, ant colony optimization, and particle swarm optimization. The description of these architectures as CNs allows their comparison, distinguishing which properties enable them to perform complex computations and exhibit complex cognitive abilities. In this context, the most relevant characteristics of CNs are the existence multiple dynamical and functional scales.
2010-01-01
C57BL/6J, DBA/2J, and DBA/2J.Gpnmb+ mice have different visual signal processing in the inner retina
UK PubMed Central (United Kingdom)
PurposeTo characterize differences in retinal ganglion cell (RGC) function in mouse strains relevant to disease models. C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse...Full Text Available
Energy Technology Data Exchange (ETDEWEB)
This guide is one of the actions following from the recommendations of the Thermie B project that aimed to support the development of a new European Integrated Clean Coal (CCT) Program concept (STR - 1121 - 96), November 1998. The concept aimed to enhance the market deployment of EU CCTs. This guide is prepared for EU industry to help them finding support for their CCT exports to the target markets. The guide will include easy accessible information on the most relevant EC-programs and is intended as a practical tool for EU CCT industry, to assist them in identifying and selecting the export support and programs best able to support their specific export assistance. The guide is a manual (signpost) through the 'jungle of assistance' and therefore does not include extensive information on application procedures, since this kind of information can be easily obtained, once the relevant program is ...
2000-10-11
International Nuclear Information System (INIS)
Salinisation of freshwater has been identified as a serious environmental issue in Australia and around the world. Protective concentrations (trigger values) for salinity can be used to manage salinity impacts, though require locally relevant salinity tolerance information. 72-h acute salinity tolerance values were determined for 102 macroinvertebrates collected from 11 locations in four biologically distinct freshwater bio-regions in Northeast Australia and compared with sensitivities observed in Southeast Australia. The salinity tolerance of individual taxa was consistent across Northeast Australia and between Northeast and Southeast Australia. However, two distinct communities were identified in Northeast Australia using distributions of the acute tolerance values and a calculated index of salinity sensitivity. Salinity trigger values should therefore be representative of local or regionally relevant ...
2008-02-01
Heliophysics Event Knowledgebase for the Solar Dynamics Observatory and Beyond
The immense volume of data generated by the suite of instruments on SDO requires new tools for efficient identifying and accessing data that is most relevant to research investigations. We have developed the Heliophysics Events Knowledgebase (HEK) to fill this need. The HEK system combines automated data mining using feature-detection methods and high-performance visualization systems for data markup. In addition, web services and clients are provided for searching the resulting metadata, reviewing results, and efficiently accessing the data. We review these components and present examples of their use with SDO data.
2010-01-01
The strong associations between organism characteristics and network architecture
Understanding the dependence and interplay between architecture and function in biological networks has great relevance to disease progression, biological fabrication and biological systems in general. Recent research in complex systems and networks, presents methods to properly mine the architectural interdependence in networks. Guided by such work, we propose methods to associate organism characteristics with network topology by analyzing a large number of architectural patterns. We adopt an automated approach using 11 topological metrics from complex networks to characterize a collection of various kinds of biological networks. Principal component analysis and clustering allow us to extract the indispensable, independent and informative metrics. Using hierarchical linear modeling, we observe that organism characteristics associate with these metrics, surprisingly well. This work can serve as a stepping stone to cataloging biologically ...
2009-01-01
This article examines relevant government policy documents on education and culture and discovers that Nigerian education authorities do not "discriminate" against art and culture in its articulation of educational policies per se, but lack of administrative machinery or political will has resulted in the deprivation of the Nigerian child in the process of creative activity in early childhood development. The article argues that lack of creative ability in our educational products is perhaps a major setback in the nation's quest for industrial and technological development. In this article a new art curriculum for elementary schools is advocated as a means of engaging the young child in order to attain functional educational skills necessary in the world of work.
2008-10-01
Working with activity theory: Context, technology, and information behavior
British Library Electronic Table of Contents (United Kingdom)
Abstract Over the last 7 years, the AIMTech Research Group in the University of Leeds has used cultural-historical activity theory (CHAT) to inform a range of research activities in the fields of information behavior and information systems. In this article, we identify certain openings and theoretical challenges in the field of information behavior, which sparked our initial interest in CHAT: context, technology, and the link between practice and policy. We demonstrate the relevance of CHAT in studying information behavior and addressing the identified openings and argue that by providing a framework and hierarchy of activity-action-operation and semantic tools, CHAT is able to overcome many of the uncertainties concerning information behavior research. In particular, CHAT provides resear...
2011-01-01
Body-and-cad Geometric Constraint Systems
Motivated by constraint-based CAD software, we develop the foundation for the rigidity theory of a very general model: the body-and-cad structure, composed of rigid bodies in 3D constrained by pairwise coincidence, angular and distance constraints. We identify 21 relevant geometric constraints and develop the corresponding infinitesimal rigidity theory for these structures. The classical body-and-bar rigidity model can be viewed as a body-and-cad structure that uses only one constraint from this new class. As a consequence, we identify a new, necessary, but not sufficient, counting condition for minimal rigidity of body-and-cad structures: nested sparsity. This is a slight generalization of the well-known sparsity condition of Maxwell.
2010-01-01
UK PubMed Central (United Kingdom)
BackgroundUnderstanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function...Full Text Available
UK PubMed Central (United Kingdom)
The fungus Cryptococcus neoformans is a major cause of morbidity and mortality in patients with impaired CD4+ T cell function, particularly those with AIDS. To identify...Full Text Available
2001-08-28
Measurement of Sexual Functioning After Spinal Cord Injury: Preferred Instruments
UK PubMed Central (United Kingdom)
Background/Objective:To determine the utility of certain instruments to assess sexuality and fertility after SCI, an expert panel identified key areas to study and evaluated...Full Text Available
2009-06-01
UK PubMed Central (United Kingdom)
We have identified five acyl coenzyme A (CoA) oxidase isozymes (Aox1 through Aox5) in the n-alkane-assimilating yeast Yarrowia lipolytica, encoded by the POX1...Full Text Available
1999-09-01
Sources of toxicity and exposure information for identifying chemicals of high concern to children
International Nuclear Information System (INIS)
Due to the large number of chemicals in commerce without adequate toxicity characterization data, coupled with an ineffective federal policy for chemical management in the United States, many states are grappling with the challenge to identify toxic chemicals that may pose a risk to human health and the environment. Specific populations (e.g., children, elderly) are particularly sensitive to these toxic chemicals. In 2008, the Children's Safe Product Act (CSPA) was passed in Washington State. The CSPA included specific requirements to identify High Priority Chemicals (HPCs) and Chemicals of High Concern to Children (CHCCs). To implement this legislation, a methodology was developed to identify HPCs from authoritative scientific and regulatory sources on the basis of toxicity criteria. Another set of chemicals of concern was then identified from authoritative sources, based on their potential exposure to ...
2010-11-01
Level and Trend Uncertainties of Kyoto Relevant Greenhouse Gases in Poland. Interim Report
Energy Technology Data Exchange (ETDEWEB)
The Kyoto Protocol is often described as a good first step towards reducing greenhouse gas (GHG) emissions into the atmosphere. The Protocol endorses emissions trading, joint implementation including 'bubbling' between Annex 1 Parties, and a clean development mechanism that allows Annex 1 and non-Annex 1 Parties to act together to reduce emissions. However, the anticipated permit market will not function if uncertainties are not rigorously assessed and considered in any compliance process. With no reliable verification tool, it is impossible to effectively assess the different mechanisms and activities mentioned under the Protocol. Thus, it is very important to study the uncertainties underlying the Kyoto relevant GHGs, here with reference to Poland, because without the consideration of uncertainty robust verification can not occur. This paper presents information about the data used in the calculations as well as the methods ...
2002-08-30
British Library Electronic Table of Contents (United Kingdom)
The objective of this study is to test the validity of sex determination in children and adolescents using lateral radiographic cephalometry and discriminant function analysis. Fifty male and 50 female cephalograms of Taiwanese children were used (males and females with mean age of 15.52???1.38 and 15.67???1.54?years, respectively). Twenty-two cephalometric measurements were performed using computerized cephalometry. Statistical analysis shows that all measurements were sexually dimorphic (p?0.05). Nine measurements, statistically validated and clinically relevant, were used for discriminant function analysis. A stepwise discriminant procedure selected seven of the nine variables, producing 95% accuracy in sex determination. Resubstitution classification reveals the same discriminant rat...
2010-01-01
Optimization of EB plant by constraint control
Energy Technology Data Exchange (ETDEWEB)
Optimum plant operation can often be achieved by means of constraint control instead of model- based on-line optimization. This is because optimum operation is seldom at the top of the hill but usually at the intersection of constraints. This article describes the development of a constraint control system for a plant producing ethylbenzene (EB) by the Mobil/Badger Ethylbenzene Process. Plant optimization can be defined as the maximization of a profit function describing the economics of the plant. This function contains terms with product values, feedstock prices and operational costs. Maximization of the profit function can be obtained by varying relevant degrees of freedom in the plant, such as a column operating pressure or a reactor temperature. These degrees of freedom can be varied within the available operating margins of the plant.
1991-03-01
Construction of the maximal solution of Backus? problem in geodesy and geomagnetism
British Library Electronic Table of Contents (United Kingdom)
The (simplified) Backus? Problem (BP) consists in finding a harmonic function u on the domain exterior to the three dimensional unit sphere S, such that u tends to zero at infinity and the norm of the gradient of u takes prescribed values g on S. Except for a change of sign, the solution is not unique in general. However, there is uniqueness of solutions in the class of functions with the additional property that the radial component of the gradient of u on S is nonpositive. This is the geodetically relevant case. If a solution u with this property exists, then u is the maximal solution of the problem (and -u the minimal one). In this paper we propose a method of successive approximations to get this particular solution of BP and prove the convergence for functions g close to a constant fu...
2011-01-01
Energy Technology Data Exchange (ETDEWEB)
This dissertation is concerned with the development, experimental diagnostics and mathematical modelling and simulation of polymer electrolyte fuel cells (PEFC). The central themes throughout this thesis are the closely interlinked phenomena of mass and charge transfer. In the face of developing a PEFC system for vehicle propulsion these phenomena are scrutinized on a broad range of relevant scales. Starting from the material related level of the membrane and the gas diffusion layer (GDL) we turn to length scales, where structural features of the cell additionally come into play. These are the scale of flow channels and ribs, the single cell and the cell stack followed by the cell, stack, and system development for an automotive power train. In Chapter 3 selected fundamental material models and properties, respectively, are explored that are crucial for the mathematical modelling and simulation of PEFC, as needed in some succeeding parts of this work. First, ...
2007-07-01
Summary of Omega West Reactor, Level 1, probabilistic risk assessment
International Nuclear Information System (INIS)
This paper reports on a Level 1 PRA performed on the Omega West Reactor at Los Alamos National Laboratory. A Master Logic Diagram was used to identify possible initiating events. A chi-square distribution was used to quantify initiating event frequencies given that no initiating events have occurred in 30 years of OWR operation. The PRA results are presented as both probability density function and cumulative distribution function curves.
1990-10-04
Factors affecting public and political acceptance for the implementation of geological disposal
International Nuclear Information System (INIS)
The main objective of this paper is to identify conditions which affect public concern (either increase or decrease) and political acceptance for developing and implementing programmes for geologic disposal of long-lived radioactive waste. It also looks how citizens and relevant actors can be associated in the decision making process in such a way that their input is enriching the outcome towards a more socially robust and sustainable solution. Finally, it aims at learning from the interaction how to optimise risk management addressing needs and expectations of the public and of other relevant stakeholders. In order to meet these objectives, factors of relevance for societal acceptance conditions are identified, described and analysed. Subsequently these factors are looked for in the real world of nuclear waste management through cases in several countries. The analysis is conducted ...
2007-09-02
International Nuclear Information System (INIS)
The regular inspection of No.2 plant in Sendai Nuclear Power Station was carried out from January 7 to February 8, 1985. The summary of the results of this regular inspection is as follows. The facilities as the object of inspection were radiation control facilities and waste facilities. On these facilities as the object of inspection, the appearance, disassembling, functional, performance and other inspections were carried out, and as the results, abnormality was not found at all. The works related to this regular inspection were accomplished within the range of the allowable radiation dose based on the relevant laws. (Kako, I.).
1986-01-01
Online tax payment systems as an emergent aspect of governmental transformation
British Library Electronic Table of Contents (United Kingdom)
The achievement of governmental transformation through the use of electronically delivered services is a worthy goal that requires significant planning and research to achieve. In order to reach transformational paradigm shifts in governmental operation, it will first be necessary to understand and optimize present governmental e-Service provisions. Of these, the revenue function of taxation is paramount. This paper describes factors related to the use and acceptance by accounting professionals of information technology intended to facilitate electronic tax filing systems. Though tested in the context of governmental tax management systems in Turkey, our findings on the use and acceptance of e-Tax systems are relevant and applicable to a great number of nations and contexts as the ongoing ...
2011-01-01
Nuclear data activity at Atomic Energy Research Establishment, Savar, Dhaka
Energy Technology Data Exchange (ETDEWEB)
The nuclear data activity at AERE, Savar is briefly presented in this paper. Major thrust is on the customization of cross section libraries for general purpose reactor and shielding calculations. The processing codes that are available are NJOY91.91, some AMPX-Modules and the modules in SCALE-PC. Recent measurements on cross section data over the energy range 13-15 MeV at the Institute of Nuclear science and Technology have been reviewed. Measurements and calculations are based on the determination of excitation functions of neutron induced reactions on the elements and isotopes of FRT-relevant structural materials. (author).
1995-03-01
In vivo magnetic resonance techniques and drug discovery
International Nuclear Information System (INIS)
The long and resource intensive process of drug discovery and development is confronted with the basic challenge of providing effective and safe therapies at reasonably low costs. The better the mechanism of a disease is known, the higher the probability to find an appropriate therapy. Also, the better and earlier a disease can be diagnosed and characterized, the higher the chance to be able to interfere in this process with a chemical entity. This reasoning sets the framework for the use of imaging in drug discovery. We discuss the relevance of magnetic resonance imaging and spectroscopy to derive anatomical, functional, metabolic and target-related information in the context of pharmacological research in vivo. (author)
2006-03-01
Fusion of the "8 Li + "2"0"8 Pb system at near-barrier energies studied via x n evaporation
International Nuclear Information System (INIS)
The fusion excitation function for the radioactive projectile "8 Li on a "2"0"8 Pb target has been measured at energies near the Coulomb barrier. The results show that in the considered energy interval, the evaporation of four neutrons is the most relevant mechanism. However, at the highest energies used in the experiment, the Sn channel begins to appear. The preliminary experimental cross sections show a good agreement with the predictions of a simple evaporation calculation using the code PACE. (Author) 16 refs., 1 tab., 4 figs.
2004-12-01
Chemical sensitivity of Mo gate Mos capacitors
International Nuclear Information System (INIS)
Mo gate Mos capacitors exhibit a negative shift of their C-V characteristic by up to 240 mV, at 125 C, in response to 1000 ppm hydrogen, in controlled nitrogen atmospheres. The experimental methods for obtaining capacitance and conductance, as a function of polarisation voltage, as well as the relevant equivalent circuits are reviewed. The single-state interface state density, at the semiconductor-dielectric interface, decreases from 2.66 x 10"1"1 cm"-"2 e-v"-"1, in pure nitrogen, to 2.5 x 10"1"1 cm"-"2 e-v"-"1 in 1000 ppm hydrogen in nitrogen mixtures, at this temperature. (Author)
Quark-hadron duality in structure functions
Energy Technology Data Exchange (ETDEWEB)
I review recent developments in quark-hadron duality in inclusive electron-nucleon scattering. Matrix elements of twist-4 operators extracted from moments of the spin-dependent g1 structure function suggest that duality violating higher twists are small above Q2 {approx} 1 GeV2. The x dependence of local duality is analyzed within a quark model framework, and mechanisms are identified for spin-flavor symmetry breaking which underpin the behavior of structure functions at large x.
2004-10-01
Three adolescents (ages 14-17) with emotional and behavioral disorders displayed chronic disruptive behavior in their self-contained classrooms at a self-contained alternative school. A descriptive functional behavioral assessment was conducted for each student. Data from file review, structured interviews, and direct observations were used to identify the functions of their disruptive behaviors. Then, function-based interventions were systematically constructed for each student and implemented for an extended period (nearly 6 weeks) within the most problematic situation in their classrooms. The interventions improved each student's behavior and the effects maintained during follow-up and generalized to instruction in a nonintervention classroom. Social validity data comparing the interventions to baseline practices revealed the function-based intervention had moderately higher ...
2011-02-01
Energy Technology Data Exchange (ETDEWEB)
Calculating work-function modifications for flat-lying conjugated molecules on extended metal surfaces using density functional theory (DFT) is an extremely resource intensive task. This prevents fast screening of new molecules for their potential to optimize metal work functions for good electron or hole injection in organic electronic devices. We present a semi-classical model, which avoids that problem. This is achieved by identifying the dominant processes occurring at the interface between metal and adsorbate in the pinning-regime, which are then parameterizing their description using band-structure DFT calculations for a small training set With the resulting interdependent equations at hand, only simple gas-phase calculations are needed to predict the work-function changes induced by new molecules. The model is tested for ten molecules on three different metal surfaces, where ...
2010-07-01
Critical review of studies on atmospheric dispersion in coastal regions
Energy Technology Data Exchange (ETDEWEB)
This study effort was required as a preliminary step prior to initiation of field measurements of atmospheric dispersion in coastal regions. The Nuclear Regulatory Commission (NRC) is in the process of planning an extensive field measurement program to generate data which will serve as improved data bases for licensing decisions, confirmation of regulations, standards, and guides, and for site characterizations. The study being reported here is an effort directed to obtaining as much information as is possible from existing studies that is relevant toward NRC's objectives. For this study, reports covering research and meteorological measurements conducted for industrial purposes, utility needs, military objectives, and academic studies were obtained and critically reviewed in light of NRC's current data needs. This report provides an interpretation of the extent of existing usable information, an indication of the potential for tailoring existing ...
1982-09-01
Corrosion of high-level waste packaging materials in disposal relevant brines
International Nuclear Information System (INIS)
Previous corrosion studies identified the materials Hastelloy C4, Ti 99.8-Pd, and carbon steels as promising for the manufacture of long-lived high-level waste containers that could act as an engineered barrier in a rock-salt repository. Here, the efficiency of the corrosion-resistant concept using surface-welded Hastelloy C4 as corrosion protection of carbon steel containers is compared with the corrosion-allowance concept using unalloyed or low-alloyed steels. The materials are examined in three disposal relevant brines (two rich in MgCl_2, one rich in NaCl) at 150 C. The results indicate that welded Hastelloy C4 is highly resistant to corrosion in the NaCl-rich brine. In the presence of sulfides or MgCl_2-rich brines, however, severe pitting corrosion occurs. The three steels investigated are resistant to pitting corrosion in all brines, and their general corrosion rates imply corrosion allowances acceptable for thick-walled containers. In ...
To illustrate the implementation of a bottom-up approach to the study of culture in health disparities, this article describes the development of a cultural cancer screening scale (CCSS) using mixed methodologies. The aim was to identify cultural factors relevant to breast and cervical cancer screening, develop an instrument to assess them and examine its preliminary psychometric properties among Latin American (Latino) and non-Latino White (Anglo) women in Southern California. Seventy-eight Latino and Anglo women participated in semi-structured interviews, which were content coded based on Triandis' methods for the analysis of subjective culture. Based on the emerging cultural elements, items relevant to cancer screening were developed and pilot tested with 161 participants. After the instrument was refined, 314 Latino and Anglo women from various socioeconomic backgrounds completed the CCSS and data were factor analyzed ...
2010-09-23
What density-functional theory can tell us about the spin-density wave in
International Nuclear Information System (INIS)
The energy-versus-volume curve of the spin-density wave (SDW) in body-centred-cubic Cr is calculated with the density functional theory/full-potential linearized augmented plane wave (DFT/FLAPW) method using the generalized gradient approximation (GGA). The predicted ground state is not the SDW, in contrast to an earlier FLAPW calculation. A conjecture is formulated that the widely varying results of the local density approximation (LDA) and GGA - and of different solution methods - can be scaled by the size of the calculated moment. As a consequence, experimentally relevant properties of the SDW can be calculated by tuning the moment. The implications of these results for the ability of DFT to describe Cr are discussed. (author)
2002-04-01
P03-378 - Erectile dysfunction in psychiatric patients
British Library Electronic Table of Contents (United Kingdom)
Introduction: Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for sexual activity. Objectives: ED is a common condition in psychiatric patients, which can modify their quality of life. Aims: The aim of this study is to assess the prevalence and the severity of ED in psychiatric patients. Methods: This naturalistic, observational study was conducted during a six months period. The International Index of Erectile Function (IIEF) 15-item questionnaire was used to assess 144 male inpatients with different psychiatric disorders. IIEF is a brief, cross-culturally valid, self-administered scale for detecting treatment-related changes in patients with erectile dysfunction and addresses the relevant domains of male sexual function: erectile functi...
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
Abstract Hydrogen bonding interactions between amino acids and nucleic acid bases constitute the most important interactions responsible for the specificity of protein binding. In this study, complexes formed by hydrogen bonding interactions between cysteine and thymine have been studied by density functional theory. The relevant geometries, energies, and IR characteristics of hydrogen bonds (H-bonds) have been systematically investigated. The quantum theory of atoms in molecule and natural bond orbital analysis have also been applied to understand the nature of the hydrogen bonding interactions in complexes. More than 10 kinds of H-bonds including intra- and intermolecular H-bonds have been found in complexes. Most of intermolecular H-bonds involve O (or N) atom as H-acceptor, whereas the...
2011-01-01
Energy Technology Data Exchange (ETDEWEB)
Six safety initiatives have been identified for accelerating the resolution of waste tank safety issues and closure of unreviewed safety questions. Safety Initiative 5 is to reduce safety and environmental risk from tank leaks. Item d of Safety Initiative 5 is to complete corrosion studies of single-shell tanks to determine failure mechanisms and corrosion control options to minimize further degradation by June 1994. This report has been prepared to fulfill Safety Initiative 5, Item d. The corrosion mechanisms that apply to Hanford Site single-shell tanks are stress corrosion cracking, pitting/crevice corrosion, uniform corrosion, hydrogen embrittlement, and microbiologically influenced corrosion. The corrosion data relevant to the single-shell tanks dates back three decades, when results were obtained from in-situ corrosion coupons in a few single-shell tanks. Since that time there have been intertank transfers, evaporation, and chemical ...
1994-06-01
Energy Technology Data Exchange (ETDEWEB)
The pollution of the aquatic zones grows with the time, principally due to industrial and urban settlements, among others, in the surroundings of these sites. The sources of this pollution can be identified by the study of the characteristics of the sediment, this gives relevant information to evaluate any aquatic system. Once the sediment is obtained, a series of preliminary tests are carry out (loss of ignition, 210{sup P}b dating) to be sure that we have a sedimentary core that hans .t be mixed, once this has be done we determine radionuclides, heavy metals and organic compounds. (Author) 2 refs.
2008-07-01
The compatibility of alloy 800 in HTR atmospheres
International Nuclear Information System (INIS)
A thermodynamic analysis of the behaviour of Alloy 800 in helium based atmospheres relevant to the High Temperature Gas Cooled Reactor indicates that, depending upon the precise gas composition, oxidation and carburisation, or carburisation alone may be expected. The prime influence appears to be the moisture level. The morphology and structure of the reaction products are discussed. It is shown that the 'reactive' elements chromium, manganese, titanium and silicon are concentrated in the oxide scale which is normally duplex in structure. Aluminium oxide is formed at grain boundaries and in an internal oxidation zone together with titanium and sometimes silicon. In carburising conditions, mixed titanium-chromium carbides are formed. When this occurs, intergranular penetration is maximised. Weight gain data are assessed and briefly described and a tentative model for the mechanism of corrosion of Alloy 800 in HTR helium is proposed. Areas for further work are ...
International Nuclear Information System (INIS)
The point at which the common final pathway for induction of cancer by chemical carcinogens and ionizing radiation has not been identified. Although common molecular targets are suggested by recent findings about the role of oncogenes, the mechanism by which the deposition of radiation energy and the formation of adducts or other DNA lesions induced by chemicals affects the changes in the relevant targets may be quite different. The damage to DNA that plays no part in the transformation events, but that influences the stability of the genome, and therefore, the probability of subsequent changes that influence tumorigenesis may be more readily induced by some agents than others. Similarly, the degree of cytotoxic effects that disrupt tissue integrity and increase the probability of expression of initiated cells may be dependent on the type of carcinogen. Also, evidence was presented that repair of the initial lesions could be demonstrated after ...
1984-05-20
British Library Electronic Table of Contents (United Kingdom)
Coumarin (1,2-benzopyrone) is occurring in food, and is also used in cosmetics. In order to perform a risk assessment for both oral and dermal exposure, we applied a physiologically based approach to model kinetics in humans by simulating both routes of exposure. The concentration-time profile in liver revealed a higher peak concentration (Cmax-hep) for the oral when compared to the dermal route. The area under the concentration-time curve in the liver (AUChep) was found the same for both routes if the same extent of absorption is assumed. Dose response information from published rat studies were used to identify the metric relevant for liver toxicity. Liver exposure levels resulting from doses and durations as outlined in the studies were simulated in a rat model. We obtained 31 data pair...
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
Considering the status of knowledge on corrosion and corrosion protection and especially the need for long term compatibility data of structural materials in HLM a set of experiments to generate reliable long term data was defined and performed. The long term corrosion behaviour of the two structural materials foreseen in ADS, 316L and T91, was investigated in the design relevant temperature field, i.e. from 300 to 550degreeC. The operational window of the two steels in this temperature range was identified and all oxidation data were used to develop and validate the models of oxide scale growth in PbBi. A mechanistic model capable to predict the oxidation rate applying some experimentally fitted parameters has been developed. This model assumes parabolic oxidation and might be used for de...
2011-01-01
Landscapes are both a synthesis and an expression of national, regional and local cultural heritages. It is therefore very important to develop techniques aimed at cataloguing and archiving their forms. This paper discusses the LDL (Landscape Digital Library) project, a Web accessible database that can present the landscapes of a territory with documentary evidence in a new format and from a new perspective. The method was tested in a case study area of the river Po valley (Northern Italy). The LDL is based on a collection of photographs taken following a systematic grid of survey points identified through topographic cartography; the camera level is that of the human eye. This methodology leads to an innovative landscape archive that differs from surveys carried out through aerial photographs or campaigns aimed at selecting "relevant" points of interest. Further developments and possible uses of the LDL are also discussed.
2001-01-01
Is XMRV a causal virus for prostate cancer?
British Library Electronic Table of Contents (United Kingdom)
The potential association between xenotropic murine leukaemia virus-related gammaretrovirus (XMRV) and prostate cancer (PCa) has been documented since 2006. It is important for furthering our understanding of the biological mechanisms of PCa to ascertain whether this association is causal. To summarize the available information on the epidemiological and laboratory findings of the association, we conducted a literature search of the PubMed electronic database (from March 2006 to February 2011) to identify relevant published studies that examined the association between XMRV and PCa. Although several studies showed the positive association between XMRV and PCa, more recent studies did not support this conclusion. The positive findings might be due to contamination of human samples. Further ...
2011-01-01
Interplay between coherence and decoherence in LHCII photosynthetic complex
This paper investigates the dynamics of excitonic transport in photocomplex LHCII, the primary component of the photosynthetic apparatus in green plants. The dynamics exhibits a strong interplay between coherent processes mediated by the excitonic Hamiltonian, and incoherent processes due to interactions with the environment. The spreading of the exciton over a single monomer is well described by a proper measure of delocalization that allows one to identify two relevant time scales. An exciton initially localized in one chromophore first spreads coherently to neighboring chromophores. During this initial coherent spreading, quantum effects such as entanglement play a role. As the effects of a decohering environment come into play, coherence and decoherence interact to give rise to efficient and robust excitonic transport, reaching a maximum efficiency at the levels of decoherence found in physiological conditions. We analyze the efficiency for ...
2011-01-01
International Nuclear Information System (INIS)
The research project had the aim to develop a standard for measuring individual, inner stresses from polycyclic aromatic hydrocarbons (PAHs) at work. The employed method was by characterizing PAHs and metabolites of PAHs to be identified in urine with a view to developing a biological monitoring of professionally exposured persons. Using a number of PAHs relevant to work, the following questions were studied in cell culture systems and different animal-experimental models: Which metabolites are formed from the PAHs used in cell culture systems and the different animal-experimental models, and what are their ratios in percent? What percentage of a PAH is excreted by experimental animals in their urine and faeces on the first, second, and third day following different forms of application? What is the scale of the individual range of variation of PAH mass excretion? Are these results transferable to man? (orig.).
1992-01-01
British Library Electronic Table of Contents (United Kingdom)
Objective: Atherosclerosis is an inflammatory disease, modulated by plaque stabilizing and de-stabilizing cell populations such as infiltrating monocytes and vascular smooth muscle cells (vSMCs). Transcription factors regulating proliferation and differentiation of atherosclerosis relevant cell types are of interest in this context. The forkhead box transcription factor FoxP1 modulates monocyte differentiation. We studied FoxP1 expression in atherosclerotic tissue, correlated FoxP1 expression with plaque characteristics and identified associations between FoxP1 and plaque proteins. Methods: 116 Atherosclerotic plaques from carotid endarterectomy samples were histologically classified (fibrous, fibroatheromatous, atheromatous) and subjected to semi-quantitative protein analysis. Macrophage,...
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
Ethnopharmacological relevance: For thousands of years, medicinal plants have played an important role throughout the world in treating and preventing a variety of diseases. Kani tribal people in Tirunelveli hills still depend on medicinal plants and most of them have a general knowledge of medicinal plants which are used for first aid remedies, to treat cough, cold, fever, headache, poisonous bites and some simple ailments. Aim of the study: The present study was initiated with an aim to identify traditional healers who are practicing herbal medicine among the Kani tribals in Tirunelveli hills of Western Ghats, India and quantitatively document their indigenous knowledge on the utilization of medicinal plants particularly most common ethnomedicinal plants. Methods: Field study was carried...
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
Knowledge on environmental variability and how it is affected by disturbances is crucial for understanding patterns of biodiversity and determining adequate conservation strategies. The aim of this study is to assess environmental variability in patches undergoing post-fire vegetation recovery, identifying trends of change and their relevant drivers. We particularly evaluate: the value of three spectral indices derived from Landsat satellite data [Normalized Burn Ratio (NBR), Normalized Difference Vegetation Index (NDVI) and Wetness Component of the Tasseled Cap Transformation (TCW)] for describing secondary succession; the effectiveness of three metrics (diversity, evenness and richness) as indicators of patch variability; and how thematic resolution can affect the perception of environme...
2010-01-01
British Library Electronic Table of Contents (United Kingdom)
Reasons for variation in transfusion practice in orthopedic surgery are not well understood. This systematic review identified and appraised the quality of the literature in this area to assess the impact of factors associated with the use of allogeneic red blood cell (RBC) transfusion in orthopedic procedures. MEDLINE and EMBASE databases were searched for relevant English language publications. Articles containing a range of MeSH and text terms regarding ''blood transfusion,'' ''predictors,'' and ''multiple logistic regression'' were retrieved. Articles that focused on patients undergoing orthopedic procedures and that met prespecified inclusion criteria were appraised in terms of potential bias and the appropriateness of statistical approach. A total of 3641 citations were retrieved, an...
2011-01-01
Design principles for CANDU control centres in response to evolving utility business needs
Energy Technology Data Exchange (ETDEWEB)
Nuclear generation operators are facing a challenging business environment at the beginning of the new millennium. Evolving changes in business context, competitive commercial pressures, and changes in technology have dictated recurring evaluation of operational practices and the adequacy of supporting tools, and the pursuit of opportunities for operational improvement. A key area of utility operations that has been impacted by these changes is the nuclear plant control centre. Changes to workspace layout, equipment provisions, staffing, and work organization are examples of some of the adjustments being introduced to improve operational and safety effectiveness. This paper discusses some of the key factors influencing these changes and identifies additional design principles for CANDU control centres that will enable new control centre designs and retrofits of existing control centres to remain relevant and responsive to utility needs. ...
2002-07-01
British Library Electronic Table of Contents (United Kingdom)
Internal amplification controls (IACs) were constructed for incorporation into real-time nucleic acid amplification assays for bovine polyomavirus, hepatitis A virus, hepatitis E virus, human adenovirus, human norovirus genogroup I, human norovirus genogroup II, murine norovirus and porcine adenovirus. The addition of optimised amounts of IAC into the assays did not affect the limits of detection for each specific target virus. A poorly performed extraction of viral nucleic acids was simulated, and the effectiveness of IACs in identifying failed assays was demonstrated. The IACs constructed in this study can be reliably used in their specific assays to provide a robust control that can be routinely applied in the analysis of foods for viruses.
2011-01-01
Atomic processes in high temperature plasmas
International Nuclear Information System (INIS)
Much theoretical and experimental efforts have been expended in recent years to study those atomic processes which are specially relevant to understanding high temperature laboratory plasmas. For magnetically confined fusion plasmas, the temperature range of interest spans from the hundreds of eV at plasma edges to 10 keV at the center of the plasma, where most of the impurity ions are nearly fully ionized. These highly stripped ions interact strongly with electrons in the plasma, leading to further excitation and ionization of the ions, as well as electron capture. Radiations are emitted during these processes, which easily escape to plasma container walls, thus cooling the plasma. One of the dominant modes of radiation emission has been identified with dielectronic recombination. This paper reviews this work.
1990-01-01
A new model of coal-water interaction and relevance for dewatering
Energy Technology Data Exchange (ETDEWEB)
This project is concerned with a basic scientific question concerning the properties of coal--to what extent is the ability of coal to hold moisture a manifestation of the well-known ability of coal to swell, when exposed to good solvents The question implies that the long-held belief that coal holds a significant portion of its moisture by classical capillary condensation processes, is possibly in error. It is likely that a sound approach to permanent drying would involve highly crosslinking the coal at mild drying conditions. The crosslinked coal could not swell sufficiently to hold much water. It is identifying processes to achieve this goal, that constitute the objective of the second phase of this work. 25 refs., 4 figs., 1 tab.
1991-01-01
Waste Sampling and Characterization Facility (WSCF). Maintenance Implementation Plan
Energy Technology Data Exchange (ETDEWEB)
This Maintenance Implementation Plan has been developed for maintenance functions associated with the Waste Sampling and Characterization Facility (WSCF). This plan is developed from the guidelines presented by Department of Energy (DOE) Order 4330.4A, Maintenance Management Program (DOE 1990), Chapter II. The objective of this plan is to provide baseline information for establishing and identifying WHC conformance programs and policies applicable to implementation of DOE order 4330.4A guidelines. In addition, this maintenance plan identifies the actions necessary to develop a cost-effective and efficient maintenance program at WSCF.
1993-07-01
British Library Electronic Table of Contents (United Kingdom)
Objectives: Intra-operative cisplatin-based intra-peritoneal chemotherapy (IPC) may alter renal function in patients with advanced ovarian cancer. The aim of this study was to describe postoperative alteration of renal function after cisplatin-based IPC and to identify risk factors for moderate to severe acute renal failure. Study design: This prospective observational study was carried out on 77 consecutive patients who underwent cisplatin-based IPC procedures, with (n=23) or without (n=54) intra-peritoneal epinephrine, for advanced ovarian cancer. Postoperative renal function was assessed using serial serum creatinine measurements and was based on serum creatinine changes from pre-operative values, according to the risk, injury, failure, loss, end-stage kidney disease (RIFLE) classificat...
2011-01-01
Normal and abnormal water diffusion in the brain
International Nuclear Information System (INIS)
Diffusion magnetic resonance imaging (MRI) has become an important tool in the radiologic diagnosis of diseases of the brain as it measures molecular motion of water that characterizes the microstructure of tissues. Its most important clinical use to date is the early detection of cerebral ischemia by revealing the ischemic injury shortly after vessel occlusion and simultaneously providing therapy-relevant information on the tissue at risk. Furthermore, diffusion MRI is diagnostically promising in other diseases of the brain and is thus increasingly becoming part of routine clinical protocols in the diagnosis of tumors, inflammation, trauma, demyelination, dysmyelination and neurodegeneration. Although abnormalities of diffusion are generally not pathognomonic, diffusion MRI affords information about tissue changes for specific disorders that complements information obtained with standard MR techniques and frequently shows pathology earlier. In addition, diffusion ...
2003-10-01
The relevance of the teacher to the success of any education innovation is not open to contention. Equally incontentious is the relevance of education and training to the success of the teacher in the attainment of his/her professional goals. It is against this background that this paper examines the continuing education imperatives in the present basic education crusade in Nigeria. Here continuing education is conceptualized as a process for developing teacher's skill for coping with changing demands of the job through regular exposure to professional renewal programmes. The paper contends that inasmuch as the teacher will continue to play a pivotal role in the execution of educational innovations, then further education and training as it affects him/her must receive priority attention in the conceptualization and implementation of such innovations. To this end, the paper advocates: teacher exchange programmes between Nigeria and other ...
2003-12-01
International Nuclear Information System (INIS)
A case study is presented where an integrated, ecologically relevant exposure assessment is presented for a polluted lowland river. Using partial least squares regression of latent structures (PLS), an analysis of the impact of two effluents on physico-chemical water quality measures, macroinvertebrate and diatom communities, and in situ bioassay responses with four different test species are combined into an integrative exposure assessment. Bioassays focussed on growth and condition related endpoints, because they are key functional processes of organisms and populations. Integrating these multiple lines of evidence, we were able to discriminate among the impact of both effluents, link changes in physico-chemical water quality with bioassay endpoints and ecological quality of the ecosystem, and address the importance of integrating all information into one exposure assessment framework. The bioassays under field conditions indicated that most ...
2004-11-01
Energy Technology Data Exchange (ETDEWEB)
Various measurement tools that are used in chaos theory were applied to analyze two-phase pressure signals with the objective of identifying and interpreting flow pattern transitions for two-phase flows in a small, horizontal rectangular channel. These measurement tools included power spectral density function, autocorrelation function, pseudo-phase-plane trajectory, Lyapunov exponent,s and fractal dimensions. It was demonstrated that the randomlike pressure fluctuations characteristic of two-phase flow in small rectangular channels are chaotic, and governed by a high-order deterministic system. The correlation dimension is potentially a new approach for identifying certain two-phase flow patterns and transitions.
1996-06-01
Selection of reference soils for chemicals testing in the European Community
International Nuclear Information System (INIS)
Based on an multivariate statistical evaluation of binary and metric data relating to the soil cover of the European Community five regionally representative reference soils (EURO-Soils) have been identified for chemicals testing in the EC. The soil material sampled at representative localities in Italy, Greece, Great Britain, France and Germany was treated and prepared according to OECD Test Guideline 106 and analysed in detail. The homogenised specimens were subject to an EC-wide ring test to evaluate the feasibility of the modified guideline and to validate the physical-chemical amenability of the reference soils for sorption tests. The results proved the validity of the soils selected for assessing the potential behaviour of new chemicals in soil on the basis of a comparative evaluation of the individual test results obtained. In the light of this parametric assessment potential test soils were subsequently identified in the individual EC ...
Interpreting Mammalian Evolution using Fugu Genome Comparisons
Energy Technology Data Exchange (ETDEWEB)
Comparative sequence analysis of the human and the pufferfish Fugu rubripes (fugu) genomes has revealed several novel functional coding and noncoding regions in the human genome. In particular, the fugu genome has been extremely valuable for identifying transcriptional regulatory elements in human loci harboring unusually high levels of evolutionary conservation to rodent genomes. In such regions, the large evolutionary distance between human and fishes provides an additional filter through which functional noncoding elements can be detected with high efficiency.
2004-04-02
Factors affecting public and political acceptance for the implementation of geological disposal
International Nuclear Information System (INIS)
This publication identifies conditions which affect (either increase or decrease) public concern for and political acceptance of the development and implementation of programmes for geological disposal of long lived radioactive waste. It also looks at how interested citizens can be associated in the decision making process in such a way that their input enriches the outcome of a more socially robust and sustainable solution. The publication also considers how to optimize risk management, addressing the needs and expectations of the public and of other relevant stakeholders. Factors of relevance for societal acceptance conditions are identified for the different stages of a repository programme and implementation process, from policy development to the realization of the repository itself. Further, they are described and analysed through case studies from several countries, illustrating the added value ...
2009-09-01
Energy Technology Data Exchange (ETDEWEB)
We present high-quality X-ray scattering experiments on pure water taken over a temperature range of 2 to 77 C using a synchrotron beam line at the advanced light source (ALS) at Lawrence Berkeley National Laboratory. The ALS X-ray scattering intensities are qualitatively different in trend of maximum intensity over this temperature range compared to older X-ray experiments. While the common procedure is to report both the intensity curve and radial distribution function(s), the proper extraction of the real-space pair correlation functions from the experimental scattering is very difficult due to uncertainty introduced in the experimental corrections, the proper weighting of OO, OH, and HH contributions, and numerical problems of Fourier transforming truncated data in Q-space. Instead, we consider the direct calculation of X-ray scattering spectra using electron densities derived from density functional theory based on ...
2003-03-01
Loss of light charged particles by nuclear interactions in BaF[sub 2] crystals
Energy Technology Data Exchange (ETDEWEB)
The nuclear interaction probability of light charged particles in BaF[sub 2] crystals has been studied as a function of the incident particle energy. Light charged particles were identified in charge and mass by measuring their magnetic rigidity and their time-of-flight. The percentage of particles undergoing nuclear interactions has been measured for particles of charge from Z=1 to Z=6 and the experimental data are compared with the results of a model calculation. (orig.)
1993-07-15
Energy Technology Data Exchange (ETDEWEB)
The study concludes that while the diversification into nonutility activities by the Rural Electric Cooperatives and the Rural Telephone Cooperatives has been expanding, the regulatory activities by the Rural Electrification Administration and the state public utility commissions have been inadequate to guard against cross-subsidization. In fact, there generally exist no data to identify and investigate illegal cross-subsidization activities of cooperatives. Increasing the regulatory functions of state public utility commissions and the REA was recommended.
1989-05-01
Alignments of multi-quasiparticle bands and seniority-dependent reduced pairing
Energy Technology Data Exchange (ETDEWEB)
Pairing correlations in multi-quasiparticle states in deformed nuclei are expected to be reduced because of blocking. New intrinsic states and their associated rotational bands have been identified allowing comparisons to be made as a function of seniority and between nuclei. The possible effects of the reduced pairing on the collective rotation, and its manifestation in terms of alignment, are discussed. 13 refs., 2 figs.
1994-09-01
A study on modelling of a butterfly-type control valve by a pneumatic actuator
Energy Technology Data Exchange (ETDEWEB)
This paper studies on the modelling of a butterfly-type control valve actuating by an on-off pneumatic solenoid valve. The mathematical model is composed of nonlinear differential equations three parts: (i) a solenoid valve, (ii) a pneumatic cylinder, (iii) a rotary-type butterfly valve. The flow characteristics of the butterfly control valve is analysed by a computer simulator, then its simple transfer function is identified from the step responses.
2009-07-01
Wetting failure and contact line dynamics in a Couette flow
Liquid-liquid wetting failure is investigated in a two-dimensional Couette system with two immiscible fluids of arbitrary viscosity. The problem is solved exactly using a sharp interface treatment of hydrodynamics (lubrication theory) as a function of the capillary number, viscous ratio and separation of scale, i.e. slip length versus macroscopic scale of the system. The existence of critical velocities, above which no stationary solutions are found, is analyzed in detail in terms of the relevant parameters of the system. Comparisons with existing analysis for other geometries are also carried out. A numerical method of analysis is also presented, based on diffuse interface models obtained from multiphase extensions of the lattice Boltzmann equation (LBE). Sharp interface and diffuse interface models are quantitatively compared face to face indicating the correct limit of applicability of the diffuse interface models.
2008-01-01
The electron cyclotron absorption diagnostic for the JET pumped divertor plasma
International Nuclear Information System (INIS)
We present the design of a diagnostic system to measure electron cyclotron absorption at the second harmonic E-mode resonance in the JET pumped divertor plasma. The diagnostic will measure transmission as a function of frequency along one or more sightlines from which the spatial profile of the n_eT_e product will be deduced. The divertor is briefly described, and the electron cyclotron resonance physics relevant to this measurement is reviewed. The problems of measuring transmission using an oversized transmission system are discussed and the chosen measurement technique, a swept frequency interferometer using a coherent radiation source, is described. A prototype of the instrument has been assembled to test the measurement technique. Some data demonstrating the instrument's characteristics are presented. The nonresonant losses, which may affect the interpretation of the measurement, are also discussed. (orig.).
1993-03-01
Taxa-specific heat shock proteins are over-expressed with crowding in the Australian plague locust
British Library Electronic Table of Contents (United Kingdom)
Most heat shock proteins (Hsps) function as molecular chaperones that help organisms to cope with stress. Although the best empirical evidence is related to heat shock, there is evidence that Hsps and their encoding genes are involved in resistance to other ecologically relevant types of stresses such as those imposed by high population density. We quantified density-dependent gene expression of large (i.e. Hsp40, Hsc70 and Hsp90) and small (Hsp20.5, Hsp20.6 and Hsp20.7) heat shock genes in neural tissue of fifth-instar nymphs of the Australian plague locust, Chortoicetes terminifera, using reverse transcription-quantitative PCR. Locusts are of particular interest when studying the influence of stress induced by high population density since they show an extreme form of phenotypic plastici...
2011-01-01
Optimal Dynamical Range of Excitable Networks at Criticality
A recurrent idea in the study of complex systems is that optimal information processing is to be found near bifurcation points or phase transitions. However, this heuristic hypothesis has few (if any) concrete realizations where a standard and biologically relevant quantity is optimized at criticality. Here we give a clear example of such a phenomenon: a network of excitable elements has its sensitivity and dynamic range maximized at the critical point of a non-equilibrium phase transition. Our results are compatible with the essential role of gap junctions in olfactory glomeruli and retinal ganglionar cell output. Synchronization and global oscillations also appear in the network dynamics. We propose that the main functional role of electrical coupling is to provide an enhancement of dynamic range, therefore allowing the coding of information spanning several orders of magnitude. The mechanism could provide a microscopic neural basis for ...
2006-01-01
We report electronic and magnetic structure of arsenic-doped manganese clusters from density-functional theory using generalized gradient approximation for the exchange-correlation energy. We find that arsenic stabilizes manganese clusters, though the ferromagnetic coupling between Mn atoms are found only in Mn$_2$As and Mn$_4$As clusters with magnetic moments 9 $\\mu_B$ and 17 $\\mu_B$, respectively. For all other sizes, $x=$ 3, 5-10, Mn$_x$As clusters show ferrimagnetic coupling. It is suggested that, if grown during the low temperature MBE, the giant magnetic moments due to ferromagnetic coupling in Mn$_2$As and Mn$_4$As clusters could play a role on the ferromagnetism and on the variation observed in the Curie temperature of Mn-doped III-V semiconductors.
2005-01-01
Importance of the Adrenal Gland Blood Supply During Laparoscopic Subtotal Adrenalectomy
British Library Electronic Table of Contents (United Kingdom)
Abstract Introduction: Laparoscopic subtotal adrenalectomy (LSA) has emerged as a treatment option in the management of certain adrenal pathologies. After LSA, a satisfactory blood supply to the adrenal remnant is vital to preserve steroid function. The aim of this study was to review the adrenal blood supply with relevance to LSA. Materials and Methods: The adrenal blood supply was examined in three ways: 1) a review of six previous cadaver studies looking at adrenal blood supply; 2) a review of our 164 consecutive laparoscopic adrenalectomies (LAs) (January 1999?January 2009); the details of the main adrenal veins and variants had been prospectively recorded; and 3) dissection of 4 cadaver specimens (macroscopic and histologic examination was performed). Results: The six cadaver studies ...
2010-01-01
Human brain development in infants with PET and FDG
International Nuclear Information System (INIS)
The authors used studies of local cerebral metabolic rate for glucose (LCMRGlc) to examine development of cerebral organization in 5 days to 1 year old children. A group (n=8) of infants with diverse pediatric disorders allowed investigation of developmental changes in LCMRGlc, while also providing relevant clinical management information. Patients consisted of questionable and definite neonatal seizures, cerebral embolism from cardiac sources, and otherwise normal infants with facial nevi with consideration of Sturge-Weber. Gradual increase in cortical LCMRGlc coincides with suppression of intrinsic subcortical reflexes present in all newborns. Two retarded children (2 years old) showed LCMRGlc developmental patterns of a few days old, which corresponded to their functional and mental status. These studies illustrate great potential of PET to study normal and altered states of human brain development.
1985-06-02
An historical view of the pineal gland and mental disorders
British Library Electronic Table of Contents (United Kingdom)
Since Classical Antiquity numerous authors have linked the origin of some mental disorders to physical and functional changes in the pineal gland because of its attributed role in humans as the connection between the material and the spiritual world. The pineal organ was seen as a valve-like structure that regulated the flow of animal spirits through the ventricular system, a hypothesis that took on more vigour during the Middle Ages and the Renaissance. The framework for this theory was ''the three cells of the brain'', in which the pineal gland was even called the ''appendix of thought''. The pineal gland could also be associated with the boom, during this period, of certain legends about the ''stone of folly''. But the most relevant psychopathological role of this organ arrived with Des...
2011-01-01
Using data from atmospheric neutrino mixing, and a simple functional form for mixing angles, the absolute values of three neutrino masses are calculated: $m_3\\cong 5.37\\times 10^{-2} eV$, $m_2\\cong 1.94\\times 10^{-2} eV$, $m_1\\cong 1.46\\times 10^{-2} eV$. The quantities relevant for solar neutrino mixing are calculated: $(m_2^2-m_1^2) \\cong 1.63\\times 10^{-4} eV^2$, with non-maximal mixing $\\tan^2\\theta_\\sol \\cong 0.56$. The analysis gives a suggestion of a dynamical origin for the empirical, large CP-violating phase associated with an intrinsically, very small mixing angle in the quark sector.
2003-01-01
Energy Technology Data Exchange (ETDEWEB)
A classic sum rule by Das et al. is extended to seven of the low-energy constant K{sub i}, introduced by Urech, which parameterizes electromagnetic corrections at chiral order O(e{sup 2}p{sup 2}). Using the spurion formalism, a simple convolution representation is shown to hold and the structure in terms of the chiral renormalization scale, QCD renormalization scale and the QED gauge parameter is displayed. The role of the resonances is studied as providing rational interpolants to relevant QCD n-point functions in the Euclidean domain. A variety of asymptotic constraints must be implemented which have phenomenological consequences. A current assumption concerning the dominance of the lowest-lying resonances is shown clearly to fail in some cases. (author)
1999-10-01
British Library Electronic Table of Contents (United Kingdom)
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development. Major recent developments in astrocyte biology and the discovery of novel intermediate filament functions enticed the interest in the function of GFAP. The discovery of various GFAP splice variants gave an additional boost to explore this protein in more detail.The structural role of GFAP in astrocytes has been widely accepted for a long time, but over the years, GFAP has been shown to be involved in astrocyte functions, which are important during regeneration, synaptic plasticity and reactive gliosis. Moreover, different subpopulations of astrocytes have been identified, which are likely to have distinc...
2011-01-01
Cross-Cultural Studies of Personality Traits and their Relevance to Psychiatry
UK PubMed Central (United Kingdom)
AimsThis article provides a brief review of recent cross-cultural research on personality traits at both individual and culture levels, highlighting the relevance...Full Text Available
2006-01-01
Energy Technology Data Exchange (ETDEWEB)
The CASTOC project addresses environmentally assisted cracking (EAC) phenomena in low alloy steels used for pressure boundary components in both Western type boiling water reactors (BWR) and Russian type pressurised water reactors (VVER). It comprises the four work packages (WP): inter-laboratory comparison test (WP1); EAC behaviour under static load (WP2), EAC behaviour under cyclic load and load transients (WP3); evaluation of the results with regard to their relevance for components in practice (WP4). The use of sophisticated test facilities and measurement techniques for the on-line detection of crack advances have provided a more detailed understanding of the mechanisms of environmentally assisted cracking and provided quantitative data of crack growth rates as a function of loading events and time, respectively. The effect of several major parameters controlling EAC was investigated with particular emphasis on the transferability of the ...
2004-07-01
Scientific Electronic Library Online (English)
Abstract in english Cytokines are molecules that were initially discovered in the immune system as mediators of communication between various types of immune cells. However, it soon became evident that cytokines exert profound effects on key functions of the central nervous system, such as food intake, fever, neuroendocrine regulation, long-term potentiation, and behavior. In the 80's and 90's our group and others discovered that the genes encoding various cytokines and their receptors are e (more) xpressed in vascular, glial, and neuronal structures of the adult brain. Most cytokines act through cell surface receptors that have one transmembrane domain and which transduce a signal through the JAK/STAT pathway. Of particular physiological and pathophysiological relevance is the fact that cytokines are potent regulators of hypothalamic neuropeptidergic systems that maintain neuroendocrine homeostasis and which regulate the body's response to ...
2000-10-01
Dependence of proton beam polarization on ion source transition configurations
Energy Technology Data Exchange (ETDEWEB)
The polarization of extracted SATURNE II proton beam as a function of different ion source configurations was studied. Two distinct experiments were necessary for this purpose. In the first one, the left-right instrumental asymmetry of the beam polarimeter was determined using an unpolarized beam. In the second one this correction factor was applied to asymmetries measured with the beam from the polarized ion source in all polarization states. The measurements were carried out at the proton beam kinetic energy 0.80 GeV, where the pp-elastic scattering analyzing power is near its maximum. The results confirmed that the two so-called ``unpolarized states`` of the source were polarized to several percent, whereas the absolute values of the beam polarizations in the so-called ``polarized states`` were equal and opposite. It was observed that the hexapole lens of the ion source produced beam polarization in the absence of any transition. The beam polarization as a ...
1997-11-11
In neurodegenerative conditions such as Alzheimer's and prion disease it has been shown that host genetic background can have a significant effect on susceptibility. Indeed, human genome-wide association studies (GWAS) have implicated several candidate genes. Understanding such genetic susceptibility is relevant to risks of developing variant CJD (vCJD) in populations exposed to bovine spongiform encephalopathy (BSE) and understanding mechanisms of neurodegeneration. In mice, aspects of prion disease susceptibility can be modelled by examining the incubation period following experimental inoculation. Quantitative trait linkage studies have already identified multiple candidate genes; however, it is also possible to take an individual candidate gene approach. Rarb and Stmn2 were selected as candidates based on the known association with vCJD. Because of the increasing overlap described between prion and Alzheimer's diseases we also chose Clu, ...
2010-12-06
RIFLE Criteria for Cardiac Surgery-Associated Acute Kidney Injury: Risk Factors and Outcomes
British Library Electronic Table of Contents (United Kingdom)
The aims of this study were to identify risk factors and evaluate the association with clinical outcomes of postoperative cardiac surgery-associated acute kidney injury (CSA-AKI). Data from 2488 consecutive adult patients were analyzed. Patients were classified as having CSA-AKI based on the risk, injury, failure, loss of kidney function, and end-stage kidney disease (RIFLE) criteria using peak postoperative creatinine in the postoperative intensive care unit (ICU). Multiple stepwise logistic regression analysis was used to identify independent risk factors for CSA-AKI. CSA-AKI occurred in 584 patients (23.5%). CSA-AKI patients had significantly longer aortic cross-clamp and cardiopulmonary bypass times. Furthermore, CSA-AKI patients had higher hospital mortality (5.5% vs 1.5%, PCopyright2...
2010-01-01
Genomic survey of prepulse inhibition in mouse chromosome substitution strains
British Library Electronic Table of Contents (United Kingdom)
Prepulse inhibition (PPI) is a measure of sensorimotor gating, a pre-attentional inhibitory brain mechanism that filters extraneous stimuli. Prepulse inhibition is correlated with measures of cognition and executive functioning, and is considered an endophenotype of schizophrenia and other psychiatric illnesses in which patients show PPI impairments. As a first step toward identifying genes that regulate PPI, we performed a quantitative trait locus (QTL) screen of PPI phenotypes in a panel of mouse chromosome substitution strains (CSSs). We identified five CSSs with altered PPI compared with the host C57BL/6J strain: CSS-4 exhibited decreased PPI, whereas CSS-10, -11, -16 and -Y exhibited higher PPI compared with C57BL/6J. These data indicate that A/J chromosomes 4, 10, 11, 16 and Y harbor...
2009-01-01
British Library Electronic Table of Contents (United Kingdom)
Action potentials from the brain control the activity of spinal neural networks to produce, by as yet unknown mechanisms, a variety of motor behaviors. Particularly lacking are details on how identified descending neurons integrate diverse sensory inputs to generate specific locomotor patterns. We have examined the operations of the principal neurons in an intriguing midbrain nucleus, the nucleus of the medial longitudinal fasciculus (nMLF), in the larval zebrafish. The nMLF is the most rostral grouping of neurons that projects from the brain well into the spinal cord of teleost fishes, yet there is little direct physiological data available regarding its function. We report here that a distinct set of large, individually-identifiable neurons in nMLF (the MeL and MeM neurons) are activated...
2010-01-01
British Library Electronic Table of Contents (United Kingdom)
Mutations or multiplications in a-synuclein gene cause familial forms of Parkinson disease or dementia with Lewy bodies (LB), and the deposition of wild-type a-synuclein as LB occurs as a hallmark lesion of these disorders, collectively referred to as synucleinopathies, implicating a-synuclein in the pathogenesis of synucleinopathy. To identify modifier genes of a-synuclein-induced neurotoxicity, we conducted an RNAi screen in transgenic C. elegans (Tg worms) that overexpress human a-synuclein in a pan-neuronal manner. To enhance the RNAi effect in neurons, we crossed a-synuclein Tg worms with an RNAi-enhanced mutant eri-1 strain. We tested RNAi of 1673 genes related to nervous system or synaptic functions, and identified 10 genes that, upon knockdown, caused severe growth/motor abnormalit...
2008-01-01
A neuro power system stabilizer based on adaptive control technique
Energy Technology Data Exchange (ETDEWEB)
A power system stabilizer based on GMV (Generalized Minimum Variance), one of the adaptive control techniques, is developed to enhance the dynamic performances of a power system using an Artificial Neural Network (ANN). The stabilizer consists of two parts. One part is Inverse Dynamics Neural Networks (IDNN), which is trained to identify the inverse dynamics of controlled plant and used as a one-step ahead controller, or inverse controller. The other part is Adaptive Reference Model (ARM), which prevents excessive controller output. The ARM produces the modified reference value by minimizing a cost function recursively on the assumption that the IDNN perfectly identifies the controlled plant. The IDNN is used in the minimization procedure to calculate the sensitivities. The proposed controller is simulated in a typical one-machine-infinite-bus power system to show its effectiveness to damp sustained low frequency ...
1996-12-31
Workshop on rock mechanics issues in repository design and performance assessment
Energy Technology Data Exchange (ETDEWEB)
The Center for Nuclear Waste Regulatory Analyses organized and hosted a workshop on ``Rock Mechanics Issues in Repository Design and Performance Assessment`` on behalf its sponsor the U.S. Nuclear Regulatory Commission (NRC). This workshop was held on September 19- 20, 1994 at the Holiday Inn Crowne Plaza, Rockville, Maryland. The objectives of the workshop were to stimulate exchange of technical information among parties actively investigating rock mechanics issues relevant to the proposed high-level waste repository at Yucca Mountain and identify/confirm rock mechanics issues important to repository design and performance assessment The workshop contained three technical sessions and two panel discussions. The participants included technical and research staffs representing the NRC and the Department of Energy and their contractors, as well as researchers from the academic, commercial, and international technical communities. These ...
1996-04-01
Energy Technology Data Exchange (ETDEWEB)
Using a coplanar, end-mounted antenna as a baseline, various configuration trades were performed to select a preferred solid state concept. The increase in efficiency that could be realized by use of multi bandgap solar cells, either with klystron or solid state antenna was evaluated. Satellite configurations were developed to exploit the sandwich antenna concept wherein solar cells are located on one side of the antenna panel and solid state dc/RF converters on the other side. These concepts entailed various primary and secondary reflector arrangements for directing solar energy to the solar cell side of the antenna with higher concentration ratios than used on the coplanar configurations. Operations analysis included development of a satellite construction scenario, a concept for the SCB, a top-level satellite construction operation, construction operation, construction timelines and crew sizes, mass flows to orbit, and a satellite maintenance scenario. The list of materials required ...
1981-03-01
Results of 3-dimensional structural FE-modeling of the coil end-regions of the LHC main dipoles
The transition region between the straight part and the ends of the coils of the LHC model and prototype dipole magnets are often identified as the origin of training quenches. In order to study how the discontinuities in the material properties of these regions affect coil pre-stress and possibly gain more insight in the quench behavior, a program was set up at CERN to analyze by 3D-FEM these particular regions. The ACCEL team, who performed a similar analysis for the main quadrupoles of the Superconducting Supercollider SSC, is entrusted with this program. In this paper we report on the results of 3D-modeling and analysis of the coil return end region, including the complete coil mass, of a 1-m single bore model magnet. This magnet represents all relevant features of the "two-in-one" LHC main dipole design concerning the winding configuration, the collar pack, the yoke, and the outer shell representing the He-vessel. The transition region ...
2000-01-01
Research study for extremely unlikely scenario of high level waste disposal: Part 3
Energy Technology Data Exchange (ETDEWEB)
In this research, first, event and process relevant to the key words (or scenario initiator) such as volcanism have been identified and, especially a middle-scale eruption scenario including pyroclastic flows has been analyzed as the catastrophic scenario, which inspires ordinary people to have tremendous concern. Secondly, based upon the characteristic events and processes of each scenario considered in the above and through the research of existing model of such risk, quantitative concept (release amount magnitude, release mode, release form, frequency of release, probability etc.) and impact on repository system, facility and environment have been analyzed, defended and defined. Model which can assess and analyze such impact has been built. Using these models, risks directly or indirectly caused by HLW repository have been calculated. Finally, the process for assessing the consequence of volcanism scenario and its risk calculated by the ...
1999-02-01
Modulating factors in the expression of radiation-induced oncogenic transformation
Energy Technology Data Exchange (ETDEWEB)
Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitaive are also the least relevant in terms of human carcinogenesis and human risk estimation. The development of cell culture systems has made it possible to assess at the cellular level the oncogenic potential of a variety of chemical, physical and viral agents. Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals. Permissive and protective factors in radiation-induced transformation include thyroid hormone and the tumor promoter TPA that increase the transformation incidence for a given dose of radiation, and retinoids, selenium, vitamin E, and 5-aminobenzamide that ...
1990-08-01
Modulating factors in the expression of radiation-induced oncogenic transformation
International Nuclear Information System (INIS)
Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitaive are also the least relevant in terms of human carcinogenesis and human risk estimation. The development of cell culture systems has made it possible to assess at the cellular level the oncogenic potential of a variety of chemical, physical and viral agents. Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals. Permissive and protective factors in radiation-induced transformation include thyroid hormone and the tumor promoter TPA that increase the transformation incidence for a given dose of radiation, and retinoids, selenium, vitamin E, and 5-aminobenzamide that ...
1990-01-01
Energy Technology Data Exchange (ETDEWEB)
The research project had the aim to develop a standard for measuring individual, inner stresses from polycyclic aromatic hydrocarbons (PAHs) at work. The employed method was by characterizing PAHs and metabolites of PAHs to be identified in urine with a view to developing a biological monitoring of professionally exposured persons. Using a number of PAHs relevant to work, the following questions were studied in cell culture systems and different animal-experimental models: Which metabolites are formed from the PAHs used in cell culture systems and the different animal-experimental models, and what are their ratios in percent What percentage of a PAH is excreted by experimental animals in their urine and faeces on the first, second, and third day following different forms of application What is the scale of the individual range of variation of PAH mass excretion Are these results transferable to man (orig.).
1992-01-01
Gene expression analysis after low dose ionising radiation exposure of the developing organism
International Nuclear Information System (INIS)
Measuring gene expression using microarrays is relevant to many areas of biology and medicine, such as follow up of developmental stages and diseases onset, and treatment study. Since there can be tens of thousands of distinct probes on an array, each micro array experiment can accomplish the equivalent number of genetic tests in parallel. Arrays have therefore dramatically accelerated many types of investigations. For example, microarrays can be used to identify stress response genes by comparing gene expression in challenged versus normal cells. In the Molecular and Cellular Biology lab (MCB), the micro array experiments are performed within the Genomic Platform, fully equipped to analyse either the behaviour of bacteria during long space flight, the effect of low dose ionising radiation on the developing organism in mice, or the human individual radiation sensitivity. For the low dose effect, two main stages of development are of interest; ...
2007-09-01
Energy Technology Data Exchange (ETDEWEB)
To significantly improve the simulation of climate by general circulation models (GCMs), systematic errors in representations of relevant processes must first be identified, and then reduced. This endeavor demands that the GCM parameterizations of unresolved processes, in particular, should be tested over a wide range of time scales, not just in climate simulations. Thus, a numerical weather prediction (NWP) methodology for evaluating model parameterizations and gaining insights into their behavior may prove useful, provided that suitable adaptations are made for implementation in climate GCMs. This method entails the generation of short-range weather forecasts by a realistically initialized climate GCM, and the application of six-hourly NWP analyses and observations of parameterized variables to evaluate these forecasts. The behavior of the parameterizations in such a weather-forecasting framework can provide insights on how these schemes ...
2004-05-06
Development of farmer field school methodology for smallholder dairy farmers
Environmental Research Database
SummaryIntended Outputs: Farmers' priorities in dairy health and production in the smallholder crop dairy production system defined.Methodology for applying FFS approach in the AH/LP setting developed, tested and promoted.Impact assessment of the livestock FFS approach.Establishment of a plan of action for the large-scale implementation including proposals for the Government of Kenya to seek funding.Livestock FFS manual: guidelines and reference material suitable for [continued...]ObjectivesTo adapt and test Farmer Field School (FFS) methodology for animal health and production, focussing upon smallholder dairy farmers.DescriptionProject Background: Dissemination has traditionally been seen by research and extension as finding effective ways of transferring technology, and passing on relevant, usable information to farmers. In complex situations, where farmers need to adjust to a changing situation -such as crop protection, soil nutrient management, animal health ...
2006-01-30
There is a plethora of new silver-containing dressings on the market today. Various manufacturers attempt to show that their dressings are the most efficacious and therefore should be preferentially employed by health care workers based on the results of their in vitro tests. However, there have been no studies that clearly identify which tests are appropriate for comparison purposes. The purpose of this study was to determine which in vitro test is most appropriate for evaluating the antimicrobial efficacy of silver-containing dressings. This was done by testing seven silver-containing dressings and two non-silver-containing topical agents against 17 clinically relevant microorganisms using zone of inhibition assays and time-kill kinetic assays in complex media. The results for the two assays were then correlated to determine whether the methods generated similar results. It was determined that the two methods do not correlate at all. This is ...
Assessment of four serological techniques in the immunological diagnosis of farmers' lung disease.
Farmers' lung disease (FLD) is a pulmonary disease that results from repeated inhalation of antigens from mouldy hay or straw. The objective of this prospective study was to assess the reliability of four serological techniques in FLD diagnosis. Sera from 15 consecutive patients with FLD, 15 healthy control farmers and 30 urban controls were analysed using four serological techniques [electrosyneresis (ES), Ouchterlony double diffusion (DD), ELISA and Western blot (WB)] with four antigens (Absidia corymbifera, Eurotium amstelodami, Wallemia sebi and Saccharopolyspora rectivirgula). In the authors' region, ES on cellulose acetate with A. corymbifera antigen was the most relevant diagnostic tool for discriminating FLD patients from healthy exposed farmers (sensitivity 87 %, specificity 100 %). DD tests were in accordance with ES, but their discriminatory power was lower. No threshold indicating both good sensitivity and specificity could be established with ELISA. WB ...
2007-10-01
Energy Technology Data Exchange (ETDEWEB)
The object of this research is the evaluation of the performance of ultra high speed relays (UHSR's) used for protection of a-c transmission lines. For purposes of this report, these are relays whose response time is less than a quarter of a cycle of the 60 Hz wave (i.e. 4.167 ms.). To identify relaying schemes that may comply with this definition, a literature survey was undertaken. The selected relays were studied in detail and modeled on a digital computer. A theoretical description of these relays is presented. Records of real transient data as well as of simulated data were used as input to the digital models of relays. The real data were recorded by means of monitoring stations connected to the Florida Power and Light Company transmission lines. The simulated data were obtained by modeling the relevant parts of the utility's transmission system using a University of British Columbia simplified version of the well known ...
1984-01-01
Energy Technology Data Exchange (ETDEWEB)
Ex situ and in situ fuel cell degradation of a sPAEK membrane were investigated. Post-mortem analyses of the aged membrane and of the degradation products eluted in water were carried out by NMR, IR, SEC and EDX. Ex situ agings were performed in a low concentration H{sub 2}O{sub 2} solution (0.07%) without any metallic catalyst. We exemplify that ex situ accelerated aging tests in such hydrogen peroxide solution are relevant to the chemical degradation in fuel cell. We have shown that a 500 h fuel cell test at moderate temperature (60 C) induces significant modifications on the macromolecules such as a 40% molecular weight reduction. Degradation appears heterogeneous and limited to the cathode side. The model compound approach developed in the previous article (Perrot et al.) has allowed the identification of the aging path in fuel cell. Phenolic and carboxylic acid chain ends have been identified as the main products resulting from polymer ...
2010-01-15
The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways
British Library Electronic Table of Contents (United Kingdom)
Unlike the well-characterized nuclear function of the Notch intracellular domain, it has been difficult to identify a nuclear role for the ligands of Notch. Here we provide evidence for the nuclear function of the Notch ligand Delta-like 1 in colon cancer (CC) cells exposed to butyrate. We demonstrate that the intracellular domain of Delta-like 1 (Dll1icd) augments the activity of Wnt signaling-dependent reporters and that of the promoter of the connective tissue growth factor (CTGF) gene. Data suggest that Dll1icd upregulates CTGF promoter activity through both direct and indirect mechanisms. The direct mechanism is supported by co-immunoprecipitation of endogenous Smad2/3 proteins and Dll1 and by chromatin immunoprecipitation analyses that revealed the occupancy of Dll1icd on CTGF promot...
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
DFNA5 was first identified as a gene causing autosomal dominant hearing loss (HL). Different mutations have been found, all exerting a highly specific gain-of-function effect, in which skipping of exon 8 causes the HL. Later reports revealed the involvement of the gene in different types of cancer. Epigenetic silencing of DFNA5 in a large percentage of gastric, colorectal and breast tumors and p53-dependent transcriptional activity have been reported, concluding that DFNA5 acts as a tumor suppressor gene in different frequent types of cancer. Despite these data, the molecular function of DFNA5 has not been investigated properly. Previous transfection studies with mutant DFNA5 in yeast and in mammalian cells showed a toxic effect of the mutant protein, which was not seen after transfection ...
2011-01-01
International Nuclear Information System (INIS)
The aims of this study were to quantify the severity and extent of subclinical interstitial lung disease as depicted on HRCT and to study the relationship between the patterns of lung disease quantified by HRCT and the functional parameters and bronchoalveolar lavage findings in patients with rheumatic diseases. The results confirm that HRCT is a sensitive tool in detecting interstitial lung disease in patients with rheumatic diseases with no signs and symptoms of pulmonary involvement. The relationship between the different HRCT patterns and bronchoalveolar lavage cell profiles can identify patients at higher risk of developing irreversible lung fibrosis. A long-term, prospective follow-up study is needed to determine whether these patients will develop over pulmonary disease.
1999-01-01
Role of regulatory T cell populations in controlling graft vs host disease
British Library Electronic Table of Contents (United Kingdom)
Immune function is critical in health and disease. The control and regulation of immune reactions is an area of intense investigation that has important implications for allogeneic hematopoietic cell transplantation. Immune reactions are regulated in a number of important ways. Compartmentalization of immune responses and the production of both pro-inflammatory and anti-inflammatory cytokines play a major role. More recently several populations of T cells that regulate immune responses termed regulatory T cells have been identified. This manuscript will focus on CD4^+CD25^+FoxP3^+ natural regulatory T cells (T"r"e"g) and @a@bTCR^+CD4^+NK1.1^+ natural killer T (NK-T) cells which both suppress graft vs host disease but appear to function by distinct mechanisms.
2011-01-01
Optimal invasive species management under multiple uncertainties
British Library Electronic Table of Contents (United Kingdom)
The management programs for invasive species have been proposed and implemented in many regions of the world. However, practitioners and scientists have not reached a consensus on how to control them yet. One reason is the presence of various uncertainties associated with the management. To give some guidance on this issue, we characterize the optimal strategy by developing a dynamic model of invasive species management under uncertainties. In particular, focusing on (i) growth uncertainty and (ii) measurement uncertainty, we identify how these uncertainties affect optimal strategies and value functions. Our results suggest that a rise in growth uncertainty causes the optimal strategy to involve more restrained removals and the corresponding value function to shift up. Furthermore, we also...
2011-01-01
Integrating Medical Science Liaisons into Key Account Management
British Library Electronic Table of Contents (United Kingdom)
Medical Science Liaison (MSL) teams are a well-recognized function within the pharmaceutical and medical products industries. While in most organizations, MSLs have focused on the development of relationships with individual Key Opinion Leaders, progressive companies have realized the value that MSLs can also bring to Key Account Management (KAM). This article discusses the five steps that should be followed in order to successfully integrate the support of Key Accounts into an MSL function. These include understanding the business approach to KAM, identifying what MSL resources are available, developing a comprehensive strategic plan, implementing the plan, and evaluating and making any necessary adjustments. Finally, a case example outlining the experience of a small pharmaceutical compa...
2010-01-01
In vitro atrazine-exposure inhibits human natural killer cell lytic granule release
British Library Electronic Table of Contents (United Kingdom)
The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test t...
2007-01-01
Identification of a functional nuclear export signal in the green fluorescent protein asFP499
International Nuclear Information System (INIS)
The green fluorescent protein (GFP) asFP499 from Anemonia sulcata is a distant homologue of the GFP from Aequorea victoria. We cloned the asFP499 gene into a mammalian expression vector and showed that this protein was expressed in the human lymphoblast cell line Ramos RA1 and in the embryonic kidney 293T cell line (HEK 293T). In HEK 293T cells, asFP499 was localized mainly in the cytoplasm, suggesting that the protein was excluded from the nucleus. We identified _1_9_4LRMEKLNI_2_0_1 as a candidate nuclear export signal in asFP499 and mutated the isoleucine at position 201 to an alanine. Unlike the wildtype form, the mutant protein was distributed throughout the cytoplasm and nucleus. This is First report of a GFP that contains a functional NES.
2006-04-21
Gravity Dual for a Model of Perception
One of the salient features of human perception is its invariance under dilatation in addition to the Euclidean group, but its non-invariance under special conformal transformation. We investigate a holographic approach to the information processing in image discrimination with this feature. We claim that a strongly coupled analogue of the statistical model proposed by Bialek and Zee can be holographically realized in scale invariant but non-conformal Euclidean geometries. We identify the Bayesian probability distribution of our generalized Bialek-Zee model with the GKPW partition function of the dual gravitational system. We provide a concrete example of the geometric configuration based on a vector condensation model coupled with the Euclidean Einstein-Hilbert action. From the proposed geometry, we study sample correlation functions to compute the Bayesian probability distribution.
2010-01-01
Fourier transform IR studies on the interaction of selected chemicals with isolated cuticles
International Nuclear Information System (INIS)
It is known that the plant cuticle represents the first barrier that must be overcome by any chemical reaching the plant surface from the atmosphere before entering the plant. Because of the importance of the cuticle as a barrier to penetration of a wide variety of compounds, its morphology, chemistry, and permeability have been extensively studied. However, only limited information is available on the nature of functional chemical groups present and their interaction and role during the penetration process. The usefulness of in situ Fourier transform infrared spectroscopy studies in identifying functional groups present in isolated cuticles is described and their relationships to the structure of the cuticular membrane are discussed. Applications of infrared spectroscopy on the presence and role of phenolics in the cuticle structure and during the cuticle development, nitrogen oxide binding to isolated cuticles, and the ...
Establishment of functional primary cultures of heart cells from the clam Ruditapes decussatus
British Library Electronic Table of Contents (United Kingdom)
Heart cells from the clam Ruditapes decussatus were routinely cultured with a high level of reproducibility in sea water based medium. Three cell types attached to the plastic after 2?days and could be maintained in vitro for at least 1?month: epithelial-like cells, round cells and fibroblastic cells. Fibroblastic cells were identified as functional cardiomyocytes due to their spontaneous beating, their ultrastructural characteristics and their reactivity with antibodies against sarcomeric ?-actinin, sarcomeric tropomyosin, myosin and troponin T-C. Patch clamp measurements allowed the identification of ionic currents characteristic of cardiomyocytes: a delayed potassium current (I K?slow) strongly suppressed (95%) by tetraethylammonium (1?mM), a fast inactivating potassium current (I K?fas...
2011-01-01
Bonding and microstructural stability in Ni55Ti45 studied by experimental and theoretical methods
Energy Technology Data Exchange (ETDEWEB)
Spiral orbit tribometry friction tests performed on Ni-rich Ni55Ti45 titanium ball bearings indicate that this alloy is a promising candidate for future aerospace bearing applications. Microstructural characterization of the bearing specimens was performed using transmission electron microscopy and energy dispersive spectroscopy, with NiTi, Ni4Ti3, Ni3Ti, and Ni2Ti4Ox phases identified within the microstructure of the alloy. Density functional theory was applied to predict the electronic structure of the NixTiy phases, including the band structure and site projected density of states. Ultraviolet photoemission spectroscopy was used to verify the density of states results from the density functional theory calculations, with good agreement observed between experiment and theory.
2010-11-25
Advanced experimental design applied to damage tolerance of composite materials
This paper focuses on a factorial-based design strategy. The approach provides an efficient and statistically reliable means for assessing the influence of multivariable effects. It is applied to the detection and evaluation of damage in impacted composite sandwich panels. The experimental results obtained from this test strategy are utilized to form an empirical response function. The resulting polynomial relates damage area to residual compression strength at values of independent variables for which testing did not occur. The response function also identifies nonlinear interaction effects of key variabes that cannot be easily ascertained by traditional single-variable test strategies. Independent variables evaluated include core thickness, number of face sheet plys and impact energy. The methodology presented allows the designer to predict with more confidence the damage tolerance of a composite material component, and ...
1991-01-01
Assessing digital control system dependability using the dynamic flowgraph methodology
Energy Technology Data Exchange (ETDEWEB)
Dynamic Flowgraph Methodology (DFM) is a methodological approach to modeling and analyzing the behavior of software-driven embedded systems for the purpose of reliability/safety assessment and verification. The methodology has two fundamental goals: (a) to identify how certain postulated events may occur in a system and (b) to identify an appropriate testing strategy based on an analysis of system functional behavior. To achieve these goals, the methodology employs a modeling framework in which system models are developed in terms of causal relationships between physical variables and temporal characteristics of the execution of software modules. These models are then analyzed to determine how a certain state (desirable or undesirable) can be reached. This is done by developing timed fault trees, which take the form of logical combinations of static trees relating system parameters at different points in time. The prime ...
1993-01-01
Screening Criteria for Loss of Room Cooling Failure
Energy Technology Data Exchange (ETDEWEB)
In this report, we estimated the temperature of the pump rooms and reviewed the operability of the components under the loss of the HVAC (Heating, Ventilation, and Air Condition) system. The issues relevant to the HVAC system in the PSA (Probabilistic Safety Assessment) FT (Fault Tree) model are as follows: (1) Does the loss of the HVAC system bring about a function failure of other components? (2) Can the operator take action to reduce the temperature of the room in case of a HVAC function failure? At present, we do not know whether a component will lose its function or not under the loss of the HVAC. ASME Standard describes that a recovery action can be credited if the related recovery action is included in the procedure or there are similar recovery experiences in the plant. However, there is no description about the recovery action of the HVAC in the EOP (Emergency Operation Procedure) of the UCN3, ...
2007-01-15
The use of combustible metals in explosive incendiary devices
Energy Technology Data Exchange (ETDEWEB)
We have investigated tailoring damage effects of explosive devices by addition of unconventional materials, specifically combustible metals. Initial small-scale as well as full-scale testing has been performed. The explosives functioned to disperse and ignite these materials. Incendiary, enhanced-blast, and fragment-damage effect have been identified. These types of effects can be used to extend the damage done to hardened facilities. In other cases it is desirable to disable the target with minimal collateral damage. Use of unconventional materials allows the capability to tailor the damage and effects of explosive devices for these and other applications. Current work includes testing of an incendiary warhead for a penetrator.
1996-08-01
Symbol Error Rates of Maximum-Likelihood Detector: Convex/Concave Behavior and Applications
Convexity/concavity properties of symbol error rates (SER) of the maximum likelihood detector operating in the AWGN channel (non-fading and fading) are studied. Generic conditions are identified under which the SER is a convex/concave function of the SNR. Universal bounds for the SER 1st and 2nd derivatives are obtained, which hold for arbitrary constellations and are tight for some of them. Applications of the results are discussed, which include optimum power allocation in spatial multiplexing systems, optimum power/time sharing to decrease or increase (jamming problem) error rate, and implication for fading channels.
2007-01-01
Safety review of conceptual fusion power plants
The potential public safety impacts from accidents in conceptual fusion power plants were investigated. Fusion was found to have some potential for accidents, as does any energy generating system. Functions of fusion power plants were identified that possess sufficient potential for an accidental release of toxic materials to the environment. An assessment was made of the impact of the potential accidents and recommendations are included for R and D that will allow incorporation of safety concerns in fusion power plant design. This work was based on a review of information available in conceptual design documents of fusion reactor systems.
1976-11-01
Safety review of conceptual fusion power plants
International Nuclear Information System (INIS)
The potential public safety impacts from accidents in conceptual fusion power plants were investigated. Fusion was found to have some potential for accidents, as does any energy generating system. Functions of fusion power plants were identified that possess sufficient potential for an accidental release of toxic materials to the environment. An assessment was made of the impact of the potential accidents and recommendations are included for R and D that will allow incorporation of safety concerns in fusion power plant design. This work was based on a review of information available in conceptual design documents of fusion reactor systems.
Ovarial tumours in the CT image - correlation of histology and CT diagnosis
Energy Technology Data Exchange (ETDEWEB)
The value of CT in respect of preoperative determination of tumour status and of tumour classification was studied using 127 histologically identified ovarial tumours as basis in a blind study via mutual image classification by the two participating institutes. The medium accuracy of diagnosis was 82%, but the results were found to be greatly dependent on tumour histology. Quotas of more than 90% were obtained in case of functional cysts, cystomas, cystadeno-carcinomas and dermoids, whereas classification was less successful with the other types of tumours such as germ cell tumours, tumours of the sexually differentiated stroma, metastases and tubo-ovarial abscesses.
1984-04-01
British Library Electronic Table of Contents (United Kingdom)
Abstract Silicates are one of the most important classes of compounds on this planet, and more than 1000 silicates have been identified in the mineral kingdom. Additionally, several hundreds of artificial silicates have been synthesized. The substitution of oxygen by nitrogen leads to the structurally diverse and manifold class of nitridosilicates. Silicon nitride, one of the most important non-oxidic ceramic materials, is the binary parent compound of nitridosilicates, and it symbolizes the inherent material properties of these refractory compounds. However, prior to the last decades, a broad systematic investigation of nitridosilicates had not been accomplished. In the meantime, these and related compounds have reached a remarkable level of industrial application. This review illustrates...
2011-01-01
International Nuclear Information System (INIS)
Secondary-electron emission (SEE) spectra have been obtained with the Scanning Probe Energy Loss Spectrometer at a tip-sample distance of only 50 nm. Such short working distances are required for the best theoretical spatial resolution (<10 nm). The SEE spectra of graphite, obtained as a function of tip bias voltage, are shown to correspond to unoccupied states in the electronic band structure. The SEE spectra of thin gold films demonstrate the capability of identifying (carbonaceous) surface contamination with this technique.
2009-11-25
Identification and characterization of wetlands in the Bear Creek watershed
Energy Technology Data Exchange (ETDEWEB)
The primary objective of this study was to identify, characterize, and map the wetlands in the Bear Creek watershed. A preliminary wetland categorization system based on the Cowardin classification system (Cowardin et al. 1979) with additional site-specific topographic, vegetation, and disturbance characteristic modifiers was developed to characterize the type of wetlands that exist in the Bear Creek watershed. An additional objective was to detect possible relationships among site soils, hydrology, and the occurrence of wetlands in the watershed through a comparison of existing data with the field survey. Research needs are discussed in the context of wetland functions and values and regulatory requirements for wetland impact assessment and compensatory mitigation.
1993-10-01
ICDF Complex Operations Waste Management Plan
This Waste Management Plan functions as a management and planning tool for managing waste streams generated as a result of operations at the Idaho CERCLA Disposal Facility (ICDF) Complex. The waste management activities described in this plan support the selected remedy presented in the Waste Area Group 3, Operable Unit 3-13 Final Record of Decision for the operation of the Idaho CERCLA Disposal Facility Complex. This plan identifies the types of waste that are anticipated during operations at the Idaho CERCLA Disposal Facility Complex. In addition, this plan presents management strategies and disposition for these anticipated waste streams.
2006-12-01
Holistic Approach for Critical System Security: Flooding Prevention and Malicious Packet Stopping
Denial of service attacks (DoS) can cause significant financial damages. Flooding and Malicious packets are two kinds of DoS attacks. This paper presents a new security approach which stops malicious packets and prevents flooding in the critical systems. New concepts of packet stamp a dynamic-multi-communication-point mechanism has been identified for this proposed approach to make the prevention of flooding attacks easier and the performing of malicious packet attacks harder. In addition, dynamic key encryption technique has been adapted as a part of the proposed approach to enhance its functionality.
2010-01-01
Energy control strategy for a hybrid electric vehicle
Energy Technology Data Exchange (ETDEWEB)
An energy control strategy (10) for a hybrid electric vehicle that controls an electric motor during bleed and charge modes of operation. The control strategy (10) establishes (12) a value of the power level at which the battery is to be charged. The power level is used to calculate (14) the torque to be commanded to the electric motor. The strategy (10) of the present invention identifies a transition region (22) for the electric motor's operation that is bounded by upper and lower speed limits. According to the present invention, the desired torque is calculated by applying equations to the regions before, during and after the transition region (22), the equations being a function of the power level and the predetermined limits and boundaries.
2002-08-27
Adrenocortical (dys)function in septic shock - A sick euadrenal state
British Library Electronic Table of Contents (United Kingdom)
A central feature of the endocrine pathophysiology of septic shock is thought to be the existence of adrenal dysfunction. Based on changes in glucocorticoid secretion and responsiveness, protein binding, and activity. These changes have been described by the terms "Relative Adrenal Insufficiency" (RAI), or "Critical Illness Related Corticosteroid Insufficiency" (CIRCI), and form part of the rationale for trials of glucocorticoid treatment in septic shock. Diagnostic criteria for these conditions have been based on plasma cortisol profiles and have proven notoriously difficult to establish. The uncertainty in this area arises from the inability of current tests to clearly identify who is truly glucocorticoid "deficient" at a cellular level, and hence who requires supplemental glucocorticoid...
2011-01-01
African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more productive Bos indicus zebu breeds are much more susceptible. Zebu cattle are well adapted for plowing and haulage, and increasing their tolerance of trypanosomiasis could have a major impact on crop cultivation as well as dairy and beef production. We used three strategies to obtain short lists of candidate genes within QTL that were previously shown to regulate response to infection. We analyzed the transcriptomes of trypanotolerant N'Dama and susceptible Boran cattle after infection with Trypanosoma congolense. We sequenced EST libraries from these two breeds to identify polymorphisms that might underlie previously identified quantitative trait loci (QTL), and we assessed QTL regions and candidate loci for evidence of selective ...
2011-05-18
Energy Technology Data Exchange (ETDEWEB)
Coal fired combined cycle power systems will be a sufficient way to increase the efficiency of coal combustion. However, combined cycle power systems require a reliable hot gas cleanup. Especially alkali metals, such as sodium and potassium, can lead to hot corrosion of the gas turbine blading if they condensate as sulphates. The actual work deals with the release and sorption of alkali metals in coal fired combined cycle power systems. The influence of coal composition, temperature and pressure on the release of alkali species in coal combustion was investigated and the relevant release mechanisms identified. Alumosilicate sorbents have been found that reduce the alkali concentration in the hot flue gas of the Circulating Pressurized Fluidized Bed Combustion 2{sup nd} Generation (CPFBC 2{sup nd} Gen.) at 750 C to values sufficient for use in a gas turbine. Accordingly, alumosilicate sorbents working at 1400 C have been found for the ...
2009-07-01
Energy Technology Data Exchange (ETDEWEB)
Populations living close to high-voltage transmission lines often have residential magnetic field exposures in excess of 1 [mu]T, and sometimes over 2 [mu]T. Yet, populations studied in most epidemiologic investigations of the association between residential magnetic field exposure and cancer typically have exposures below 1 [mu]T and frequently below 0.5 [mu]T. To improve statistical power and precision, it would be useful to compare high exposure populations with low exposure population. Toward this end, we have developed an automated method for identifying populations living near high-voltage transmissions lines. These populations likely have more highly exposed individuals that the population at large. The method uses a geographic information system (GIS) to superimpose digitized transmission line locations on U.S. Census block location data and then extract relevant demographic data. Analysis of data from a pilot study of the population ...
1993-12-01
International Nuclear Information System (INIS)
The present position paper addresses contemporary waste management options, weaknesses and opportunities faced by Hellenic local authorities. It focuses on state-of-the-art, tested as well as innovative, environmental management tools on a municipal scale and identifies a range of different collaboration schemes between local authorities and related service providers. Currently, a policy implementation gap is still experienced among Hellenic local authorities; it appears that administration at the local level is inadequate to manage and implement many of the general policies proposed; identify, collect, monitor and assess relevant data; and safeguard efficient and effective implementation of MSWM practices in the framework of integrated environmental management as well. This shortfall is partly due to the decentralisation of waste management issues to local authorities without a parallel substantial budgetary and capacity ...
2009-05-01
[Natriuretic peptides--relevance in intensive care].
The family of natriuretic peptides consists of the atria natriuretic peptide (ANP), the cerebral natriuretic peptide (BNP), the type C natriuretic peptide (CNP) and the peptide isolated from the dendroaspis snakes' poison (DNP), whose presence in humans has not been confirmed. The physiological function of ANP is in the control of arterial blood pressure by regulation of systemic vascular resistance of blood vessels. BNP is produced as one of the factors in the acute response to inflammatory tissue damage, mainly in coronary vessels. Increased serum concentrations of natriuretic peptides have been found in stress situations, such as trauma or major surgery, systemic hypotension, and in intrinsic myocardial dysfunction. High concentrations of natriuretic peptides were observed in severe sepsis, septic shock and in multiple organ failure, probably due to increased secretion by mediators of the inflammatory process.The highest concentrations of ANP and BNP were found ...
Visualization of growth factor receptor sites in rat forebrain
International Nuclear Information System (INIS)
It is now known that various growth factors may also act in the central nervous system. Among them, it has recently been shown that epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) may possess trophic effects in the mammalian brain. We report here on the respective autoradiographic distribution of ["1"2"5I]EGF and ["1"2"5I]IGF-I receptor binding sites in the rat brain, both during ontogeny and in adulthood. It appears that ["1"2"5I]EGF sites are mostly found in the rat forebrain during brain development. On the other hand, ["1"2"5I]IGF-I sites are more widely distributed both during ontogeny and in adulthood. These results reveal the plasticity of the expression of EGF and IGF-I receptor sites in the mammalian brain. This could be relevant for the respective role of these two growth factors in the development and maintenance of neuronal function.
Energy Technology Data Exchange (ETDEWEB)
One of our research objectives is to develop chemistry of transition metal chalcogenides which are relevant to new inorganic materials, environmental catalysts, metalloenzymes. In this context, this research project has been aimed at rational syntheses of chalcogenide complexes of electron-deficient transition metals, construction of hetero metallic clusters with high nuclearity, and elucidation of chemical properties characteristic of these metal chalcogenide compounds. We were successful in synthesizing a series of sulfide (selenide)/thiolate complexes of group 4,5 and 6 transition metal elements by making use of C-S bond cleaving reactions and anhydrous chalcogenide reagents. We also achieved construction of unprecedented large chalcogenide clusters of mixed metal systems such as [Cu{sub 4}(dppm){sub 4}MS{sub 4}] [PF{sub 6}]{sub 2} (M=Mo, W), [(Cp*WS{sub 3}Ag{sub 2}){sub 2}({mu}-Br){sub 2}]{sub {infinity}}, and [Cp*{sub 2}Mo{sub 2}Fe{sub 2}S{sub 4}]{sub ...
1998-12-16
String Junctions and Holographic Interfaces
In this paper we study half-BPS type IIB supergravity solutions with multiple $AdS_3\\times S^3\\times M_4$ asymptotic regions, where $M_4$ is either $T^4$ or $K_3$. These solutions were first constructed in [1] and have geometries given by the warped product of $AdS_2 \\times S^2 \\times M_4 $ over $\\Sigma$, where $\\Sigma$ is a Riemann surface. We show that the holographic boundary has the structure of a star graph, i.e. $n$ half-lines joined at a point. The attractor mechanism and the relation of the solutions to junctions of self-dual strings in six-dimensional supergravity are discussed. The solutions of [1] are constructed introducing two meromorphic and two harmonic functions defined on $\\Sigma$. We focus our analysis on solutions corresponding to junctions of three different conformal field theories and show that the conditions for having a solution charged only under Ramond-Ramond three-form fields reduce to relations involving the positions of the poles ...
2010-01-01
Energy Technology Data Exchange (ETDEWEB)
The third regular inspection of No.2 plant in Sendai Nuclear Power Station was carried out from December 27, 1988 to May 25, 1989. The parallel operation was resumed on April 28, 1989, 123 days after the parallel off. The facilities which were the object of inspection were the reactor proper, reactor cooling system, measurement and control system, fuel facilities, radiation control facilities, waste facilities, reactor containment installation and emergency electric power generation system. On the facilities which were the object of inspection, the appearance, disassembling, leak, function, performance and other inspections were carried out. As the results, significant in indication was observed in 8 bolts for fixing the flow-changing vanes of primary coolant pumps, and broken valve spindles were found, but other abnormality was not found. The works related to this regular inspection were accomplished within the range of the limit of radiation dose equivalent based ...
1990-03-01
International Nuclear Information System (INIS)
The second regular inspection of No.2 plant in Sendai Nuclear Power Station was carried out from October 5, 1987 to January 8, 1988. the parallel operation was resumed on December 8, 1987, 65 days after the parallel off. The facilities as the object of inspection were the reactor proper, reactor cooling system, measurement and control system, fuel facilities, radiation control facilities, waste facilities, reactor containment installation, and emergency power generation system. On these facilities as the object of inspection, the appearance, disassembling, leak, function, performance and other inspections were carried out, and abnormality was not found at all. The works related to this regular inspection were accomplished within the range of allowable dose based on the relevant laws. The main reconstruction works carried out during the period of this regular inspection were the change of the degree of enrichment from 3.15 wt.% to 3.4 wt.% for ...
1988-01-01
Energy Technology Data Exchange (ETDEWEB)
The second regular inspection of No.2 plant in Sendai Nuclear Power Station was carried out from October 5, 1987 to January 8, 1988. the parallel operation was resumed on December 8, 1987, 65 days after the parallel off. The facilities as the object of inspection were the reactor proper, reactor cooling system, measurement and control system, fuel facilities, radiation control facilities, waste facilities, reactor containment installation, and emergency power generation system. On these facilities as the object of inspection, the appearance, disassembling, leak, function, performance and other inspections were carried out, and abnormality was not found at all. The works related to this regular inspection were accomplished within the range of allowable dose based on the relevant laws. The main reconstruction works carried out during the period of this regular inspection were the change of the degree of enrichment from 3.15 wt.% to 3.4 wt.% for ...
1988-08-01
Energy Technology Data Exchange (ETDEWEB)
In the context of the research project, the physical basis of the direct decoupling of highly concentrated solar radiation in materials without the detour via absorbing heat exchanger walls was examined. Also, the first chemical processes suitable for the effective long-term storage of solar energy were analysed, relevant experiments were carried out and the necessary receiver techniques for high temperature applications were provided. The principle of direct coupling was examined on fluidized beds on the one hand and on cavity receivers, on the other hand. The contribution shows the results achieved in detail. It is recorded that first processes for storing solar energy in chemical reactions were able to be examined. Alkaline earth hydroxides accommodated in ceramic honeycomb structures seem to be possible as stores for medium temperature ranges around 500deg C. Investigations on receiver structure materials are also making progress. Highly transparent, high ...
1988-03-01
Requirements for modeling and simulation of space RSTA assets
The Department of Defense (DoD) has long depended on military support functions enabled by space reconnaissance, surveillance, and target acquisition (RSTA) assets. Future generation satellite capabilities will further push technologies in space - if the right technologies are deployed in the right numbers and with the right payloads. Modeling and simulation play major parts in developing and deploying such assets: 1) system and operational requirements determination, and 2) assessment of military utility of such assets. Each area is critical in a system"s life cycle. Requirements determination cuts across the issues of doctrine, organizations, training, materiel, leader development, personnel, and facilities (DOTMLPF). Military utility assessments are necessary to explore and quantify the military worth/benefit of space RSTA assets to operational commanders. Each of these areas requires relevant modeling/simulation tools which span the ...
2004-09-01
On the origin of the unconventional two-hole bound state in the t-J model
Energy Technology Data Exchange (ETDEWEB)
We present a description of the ground state and low-lying excited states of two holes in the 4x4 cluster t-J model in terms of a simple model for the motion of a single bipolaron. The existence of short-range antiferromagnetic correlations has been assumed. According to the suggested scenario, the formation of the bipolaron is mediated by the reduction of the magnetic energy in the case of two holes occupying nearest neighbor sites. The relevant part of the Hilbert space consists of wave functions corresponding to holes oscillating around pairs of nearest neighbor sites and trapped in a potential well due to strings of spin defects. Virtual processes which connect these states involve both the kinetic term and the transverse part of the Heisenberg Hamiltonian. Many properties of energy level schemes obtained by numerical diagonalizations such as the sequence of the lowest states for each irreducible representation of the k vector point groups ...
1994-04-01
On the origin of the unconventional two-hole bound state in the t-J model
International Nuclear Information System (INIS)
We present a description of the ground state and low-lying excited states of two holes in the 4x4 cluster t-J model in terms of a simple model for the motion of a single bipolaron. The existence of short-range antiferromagnetic correlations has been assumed. According to the suggested scenario, the formation of the bipolaron is mediated by the reduction of the magnetic energy in the case of two holes occupying nearest neighbor sites. The relevant part of the Hilbert space consists of wave functions corresponding to holes oscillating around pairs of nearest neighbor sites and trapped in a potential well due to strings of spin defects. Virtual processes which connect these states involve both the kinetic term and the transverse part of the Heisenberg Hamiltonian. Many properties of energy level schemes obtained by numerical diagonalizations such as the sequence of the lowest states for each irreducible representation of the k vector point groups ...
1993-08-01
We consider a Mobile Ad-hoc NETwork (MANET) formed by n agents that move at speed V according to the Manhattan Random-Way Point model over a square region of side length L. The resulting stationary (agent) spatial probability distribution is far to be uniform: the average density over the "central zone" is asymptotically higher than that over the "suburb". Agents exchange data iff they are at distance at most R within each other. We study the flooding time of this MANET: the number of time steps required to broadcast a message from one source agent to all agents of the network in the stationary phase. We prove the first asymptotical upper bound on the flooding time. This bound holds with high probability, it is a decreasing function of R and V, and it is tight for a wide and relevant range of the network parameters (i.e. L, R and V). A consequence of our result is that flooding over the sparse and highly-disconnected suburb can be as fast as ...
2010-01-01
Development of Efficient UV-LED Phosphor Coatings for Energy Saving Solid State Lighting
Energy Technology Data Exchange (ETDEWEB)
The University of Georgia, in collaboration with GE Global Research, has investigated the relevant quenching mechanism of phosphor coatings used in white light devices based on UV LEDs. The final goal of the project was the design and fabrication of a high-efficacy white light UV-LED device through improved geometry and optimized phosphor coatings. At the end of the research period, which was extended to seamlessly carry over the research to a follow-up program, we have demonstrated a two-fold improvement in the conversion efficiency of a white light LED device, where the increase efficacy is due to both improved phosphor quantum efficiency and lamp geometry. Working prototypes have been displayed at DOE sponsored meetings and during the final presentation at the DOE Headquarters in Washington, DC. During the first phase of the project, a fundamental understanding of quenching processes in UV-LEDs was obtained, and the relationships that describe the performance of ...
2006-05-15
Development of Efficient UV-LED Phosphor Coatings for Energy Saving Solid State Lighting
International Nuclear Information System (INIS)
The University of Georgia, in collaboration with GE Global Research, has investigated the relevant quenching mechanism of phosphor coatings used in white light devices based on UV LEDs. The final goal of the project was the design and fabrication of a high-efficacy white light UV-LED device through improved geometry and optimized phosphor coatings. At the end of the research period, which was extended to seamlessly carry over the research to a follow-up program, we have demonstrated a two-fold improvement in the conversion efficiency of a white light LED device, where the increase efficacy is due to both improved phosphor quantum efficiency and lamp geometry. Working prototypes have been displayed at DOE sponsored meetings and during the final presentation at the DOE Headquarters in Washington, DC. During the first phase of the project, a fundamental understanding of quenching processes in UV-LEDs was obtained, and the relationships that describe the performance of ...
2006-05-01
Computer Network Security: Best Practices for Alberta School Jurisdictions.
This paper provides a snapshot of the computer network security industry and addresses specific issues related to network security in public education. The following topics are covered: (1) security policy, including reasons for establishing a policy, risk assessment, areas to consider, audit tools; (2) workstations, including physical security, protecting workstation components, and computer viruses; (3) the local network, including the OSI (Open Systems Interconnection) reference model, protocols, network segmentation, network management, network sniffing, and data encryption; (4) servers, including UNIX and other server operating systems; (5) remote access, including technologies, remote access servers, protocols, and authentication/authorization; (6) crackers and hackers, including threats and hacking tools/techniques; (7) Internet firewalls, including functions, issues and problems, types, rules, logs, firewall accessories, buying a firewall, and firewall ...
1999-02-01
Energy Technology Data Exchange (ETDEWEB)
The relative abundance and variation of Cr, Co, Cd and Pb in Ascophyllum nodosum and intertidal surface sediments from six locations around the coast were assessed over six seasons. Higher Cd and Pb levels in Galway Docks and Cork Harbour were attributed to localised inputs of these metals from municipal and domestic waste, while at a reference site (Ballyconneely), high algal Cr concentrations were considered a function of geological setting rather than anthropogenic loading. Little seasonal variation was observed, with the exception of higher Co levels in plants in winter, associated with growth dynamics and increased fluvial inputs. In comparison with previously published data for metals in A. nodosum from the North Atlantic, with the exception of localised hot spots, the Irish coastline is still a relatively pristine environment. A. nodosum may be successfully and easily used as a biomonitor of metal contamination in coastal waters. - This paper provides ...
2008-03-15
International Nuclear Information System (INIS)
Techniques for reducing computation time in 3D photon dose calculations are addressed with specific emphasis given to the convolution/superposition approach. A single polyenergetic superposition model calculating absorbed dose per incident photon fluence (Gy cm"2) was developed in terms of TERMA and a total energy deposition kernel (a total point spread function). A novel approach was devised for reducing calculation time. The method, named the CF method, was based on the use of a conventional, fast model (here a modified power-law method was used) for the generation of 3D dose distributions on a fine dose matrix. Superposition calculations were carried out on a coarse matrix and calculation speed was increased simply by reducing the number of calculations. A set of correction factors was derived on the coarse grid from the ratio of the dose values from superposition to those from the conventional algorithm. These were interpolated onto the fine matrix and used to ...
1997-08-01
A dynamic approach to the Environmental Kuznets Curve hypothesis
Energy Technology Data Exchange (ETDEWEB)
The Environmental Kuznets Curve (EKC) hypothesis states that pollution levels increase as a country develops, but begin to decrease as rising incomes pass beyond a turning point. In EKC analyses, the relationship between environmental degradation and income is usually expressed as a quadratic function with the turning point occurring at a maximum pollution level. Other explanatory variables have been included in these models, but income regularly has had the most significant effect on indicators of environmental quality. One variable consistently omitted in these relationships is the price of energy. This paper analyzes previous models to illustrate the importance of prices in these models and then includes prices in an econometric EKC framework testing energy/income and CO{sub 2}/income relationships. These long-run price/income models find that income is no longer the most relevant indicator of environmental quality or energy demand. Indeed, ...
1999-02-01
A dynamic approach to the Environmental Kuznets Curve hypothesis
International Nuclear Information System (INIS)
The Environmental Kuznets Curve (EKC) hypothesis states that pollution levels increase as a country develops, but begin to decrease as rising incomes pass beyond a turning point. In EKC analyses, the relationship between environmental degradation and income is usually expressed as a quadratic function with the turning point occurring at a maximum pollution level. Other explanatory variables have been included in these models, but income regularly has had the most significant effect on indicators of environmental quality. One variable consistently omitted in these relationships is the price of energy. This paper analyzes previous models to illustrate the importance of prices in these models and then includes prices in an econometric EKC framework testing energy/income and CO_2/income relationships. These long-run price/income models find that income is no longer the most relevant indicator of environmental quality or energy demand. Indeed, we ...
1999-02-01
International Nuclear Information System (INIS)
Purpose: To quantify left ventricular function derived from retrospectively ECG-gated multislice spiral CT (MSCT) data sets in comparison to MRI. Materials and Methods: In 16 patients (14 males, 2 females, mean age 56.8 #+-# 11.5 years), retrospectively ECG-gated MSCT angiography of the coronary arteries and breath-hold steady state free precession cine MRI were performed. From MSCT data-sets, 20 axial image series were reconstructed every 5% of the RR interval. Multiplanar images were reformatted in the short axis orientation from axial images. End-systolic and end-diastolic images were selected. From these images end-systolic volume (ESV), end-diastolic volume (EDV) and stroke volume (SV) as well as the ejection fraction (EF) and myocardial mass (MM) were determined using the Simpson's method and compared with MRI. Furthermore, image quality was assessed for both imaging modalities using a four point grading scale. Results: All parameters were found to have an ...
2003-01-01
Role of limited cell replicative capacity in pathological age change. A review
Energy Technology Data Exchange (ETDEWEB)
Physiological functions are carried out by differentiated cells, with finite lifespans, which age and need to be replaced. In young individuals, tissue functions are sustained at optimal levels because cellular dysfunction and cell loss are balanced by the emergence of newly differentiated cells as stem cells and their partially differentiated descendants replicate. However, with the passage of time the mitotic rates of these cells diminish. Eventually, replications occur too infrequently to offset the loss. It is at this point that the tissue begins to show structural changes and declining function which, as they become pervasive, are identified as ageing. In this paper the theory is set forth that: (1) Diminishing mitotic activity in older tissues results from limited stem cell replicative capacity. (2) All stem cells, regardless of tissue, exhibit similar replicative patterns over time, progressing ...
1982-01-01
Radionuclide liver and bone scanning in the evaluation of patients with endometrial carcinoma
International Nuclear Information System (INIS)
Staging bone scans or skeletal surveys were obtained of 97 patients with endometrial carcinoma. Of the 77 patients with Stage I or II disease, no metastases were identified at staging. Three patients in the entire series demonstrated bony metastases; all of these metastases were detectable by radionuclide bone scan and radiographic bone survey. Eighty-nine patients were examined with radionuclide liver/spleen scanning at the time of staging. Four of the 89 initial scans were interpreted as demonstrating hepatocellular disease, and all four patients had abnormal liver function studies. Only one patient demonstrated a possible hepatic metastasis at initial diagnosis. This patient also had abnormal liver function studies. Based on these results, bone surveys and radionuclide bone scans are not indicated as screening procedures in endometrial carcinoma. It is suggested that screening for liver metastases in patients with ...
International Nuclear Information System (INIS)
A path integral evaluation of the Green's function for the hydrogen atom initiated by Duru and Kleinert is studied by recognizing it as a special case of the general treatment of the separable Hamiltonian of Liouville type. The basic dynamical principle involved is identified as Jacobi's principle of least action for given energy which is reparametrization invariant, and thus the appearance of a gauge freedom is naturally understood. The separation of variables in the operator formalism corresponds to a choice of gauge in the path integral, and the Green's function is shown to be gauge independent if the operator ordering is properly taken into account. Unlike the conventional Feynman path integral, which deals with a space-time picture of particle motion, the path integral on the basis of Jacobi's principle sums over orbits in space. We illustrate these properties by evaluating an exact path integral of the Green's ...
Dimensionless energy confinement scaling in W7-AS
International Nuclear Information System (INIS)
Energy confinement in W7-AS has been analyzed in terms of dimensionally exact form free functions employing Bayesian probability theory. The confinement function was set up as a linear combination of dimensionally exact power law terms as already proposed very early by Connor and Taylor. Generation of this expansion basis is dictated by the basic plasma model which one assumes. Based upon data accumulated in W7-AS, which contains the energy content for a wide variety of variable settings, predictions for single variable scans are made. The scaling functions for density and power scans, respectively, are in quantitative agreement with data collected in W7-AS. The result of a single variable scan is therefore already hidden in the data obtained for arbitrary variable choices and can be extracted from the latter by a proper data analysis. Furthermore, the optimal model for the description of the global transport in W7-AS is ...
1999-12-01
Energy Technology Data Exchange (ETDEWEB)
Lung cancer staging according to the TNM system is based on morphological assessment of the primary cancer, lymph nodes and metastases. All aspects of this important oncological classification are measurable with MRI. Pulmonary nodules can be detected at the clinically relevant size of 4-5 mm in diameter. The extent of mediastinal, hilar and supraclavicular lymph node affection can be assessed at the same time. The predominant metastatic spread to the adrenal glands and spine can be detected in coronal orientation during dedicated MRI of the lungs. Search focused whole body MRI completes the staging. Various additional MR imaging techniques provide further functional and clinically relevant information during a single examination. In the oncological context the most important techniques are imaging of perfusion and tumor motion. Functional MRI of the lungs complements the pure staging and improves ...
2010-08-15
Ophidian envenomation strategies and the role of purines.
Snake envenomation employs three well integrated strategies: prey immobilization via hypotension, prey immobilization via paralysis, and prey digestion. Purines (adenosine, guanosine and inosine) evidently play a central role in the envenomation strategies of most advanced snakes. Purines constitute the perfect multifunctional toxins, participating simultaneously in all three envenomation strategies. Because they are endogenous regulatory compounds in all vertebrates, it is impossible for any prey organism to develop resistance to them. Purine generation from endogenous precursors in the prey explains the presence of many hitherto unexplained enzyme activities in snake venoms: 5'-nucleotidase, endonucleases (including ribonuclease), phosphodiesterase, ATPase, ADPase, phosphomonoesterase, and NADase. Phospholipases A(2), cytotoxins, myotoxins, and heparinase also participate in purine liberation, in addition to their better known functions. Adenosine contributes to ...
2002-04-01
UK PubMed Central (United Kingdom)
Characteristics relevant to cardiovascular disease, including anthropometry, arterial blood pressure, serum cholesterol levels, chest radiography and electrocardiography, were investigated in a survey...Full Text Available
1970-01-01
International Nuclear Information System (INIS)
The sections and provisions of the X-ray Ordinance of January 8, 1987 are discussed which are of relevance to dental radiology. (DG).
Maintenance implementation plan for the B Plant/WESF. Revision 4
Energy Technology Data Exchange (ETDEWEB)
This Maintenance Implementation Plan (MIP) has been developed for maintenance functions associated with the B Plant/WESF (Waste Encapsulation Storage Facility) complex. The objective of this plan is to provide baseline information for establishing and identifying WHC conformance programs and policies applicable to implementation of DOE order 4330.4B guidelines. In addition, this maintenance plan identifies the actions necessary to develop a cost-effective and efficient maintenance program at B Plant/WESF. The B Plant WESF facility complex consists of three main facilities and several support structures located in the 200 East Area of the Hanford site. B Plant is a transition facility that is required to ensure safe storage and management of WESF (operating facility) cesium and strontium capsules. B Plant/WESF also contains substantial radiological inventory from previous campaigns. There are no production activities at B ...
1996-01-01
Identification of tumor-initiating cells in a p53-null mouse model of breast cancer.
Using a syngeneic p53-null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified, by limiting dilution transplantation and in vitro mammosphere assay, a Lin(-)CD29(H)CD24(H) subpopulation of tumor-initiating cells. Upon subsequent transplantation, this subpopulation generated heterogeneous tumors that displayed properties similar to the primary tumor. Analysis of biomarkers suggests the Lin(-)CD29(H)CD24(H) subpopulation may have arisen from a bipotent mammary progenitor. Differentially expressed genes in the Lin(-)CD29(H)CD24(H) mouse mammary gland tumor-initiating cell population include those involved in DNA damage response and repair, as well as genes involved in epigenetic regulation previously shown to be critical for stem cell self-renewal. These studies provide in vitro and in vivo data that support the cancer stem cell (CSC) hypothesis. Furthermore, this p53-null mouse mammary tumor model may allow us to ...
2008-06-15
Identification of three related human GRO genes encoding cytokine functions
International Nuclear Information System (INIS)
The product of the human GRO gene is a cytokine with inflammatory and growth-regulatory properties; GRO is also called MGSA for melanoma growth-stimulatory activity. The authors have identified two additional genes, GRO#beta# and GRO#gamma#, that share 90% and 86% identity at the deduced amino acid level with the original GRO#alpha# isolate. One amino acid substitution of proline in GRO#alpha# by leucine in GRO#beta# and GRO#gamma# leads to a large predicted change in protein conformation. Significant differences also exist in the 3' untranslated region, including different numbers of ATTTA repeats associated with mRNA instability. A 122-base-pair region in the 3' region is conserved among the three GRO genes, and a part of it is also conserved in the Chinese hamster genome, suggesting a role in regulation. DNA hybridization with oligonucleotide probes and partial sequence analysis of the genomic clones confirm that the three forms are derived from related but ...
Energy Technology Data Exchange (ETDEWEB)
This report describes the work performed during FY 1995 by Pacific Northwest Laboratory in developing and optimizing analysis techniques for identifying organics present in Hanford waste tanks. The main focus was to provide a means for rapidly obtaining the most useful information concerning the organics present in tank waste, with minimal sample handling and with minimal waste generation. One major focus has been to optimize analytical methods for organic speciation. Select methods, such as atmospheric pressure chemical ionization mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry, were developed to increase the speciation capabilities, while minimizing sample handling. A capillary electrophoresis method was developed to improve separation capabilities while minimizing additional waste generation. In addition, considerable emphasis has been placed on developing a rapid screening tool, based on Raman and infrared spectroscopy, for ...
1995-09-01
222-S Laboratory maintenance implementation plan
Energy Technology Data Exchange (ETDEWEB)
This Maintenance Improvement Plan has been developed for maintenance functions associated with the 222-S Laboratory. This plan is developed from the guidelines presented by Department of Energy (DOE) Order 4330.4B, Maintenance Management Program (DOE 1994), Chapter 11. The objective of this plan is to provide information for establishing and identifying WMH conformance programs and policies applicable to implementation of DOE Order 4330.4B guidelines. In addition, this maintenance plan identifies the actions necessary to develop a cost effective and efficient maintenance program at 222-S Laboratory. Maintenance activities are mainly going to be performed by existing maintenance organizations within Waste Management Federal Services of Hanford (WMH). Most maintenance performed at 222-S Laboratory is performed by the 222-S Laboratory maintenance organization. This 222-S Laboratory Maintenance Implementation Plan provides the ...
1997-08-13
Energy Technology Data Exchange (ETDEWEB)
Background The identification of sequences that control transcription in metazoans is a major goal of genome analysis. In a previous study, we demonstrated that searching for clusters of predicted transcription factor binding sites could discover active regulatory sequences, and identified 37 regions of the Drosophila melanogaster genome with high densities of predicted binding sites for five transcription factors involved in anterior-posterior embryonic patterning. Nine of these clusters overlapped known enhancers. Here, we report the results of in vivo functional analysis of 27 remaining clusters. Results We generated transgenic flies carrying each cluster attached to a basal promoter and reporter gene, and assayed embryos for reporter gene expression. Six clusters are enhancers of adjacent genes: giant, fushi tarazu, odd-skipped, nubbin, squeeze and pdm2; three drive expression in patterns unrelated to those of neighboring genes; the ...
2004-08-06
Investigations on solar grade silicon and process engineering of advanced silicon solar cells
Energy Technology Data Exchange (ETDEWEB)
This thesis deals with the evaluation of Solar Grade Silicon (SoG-Si) purified by different techniques, and also the fabrication and characterization of high efficiency and advanced bifacial solar cells. In the beginning of Chapter 1, various SoG-Si production methods relevant for this work are qualitatively described. The three feedstock materials used in this work are from the Fluidized Bed Reactor (FBR) process, metallurgical feedstock-I and feedstock-II process. In metallurgical feedstock-I, the lifetime of the minority charge carriers in multicrystalline silicon (mc-Si) samples at the grain boundaries are found to be higher than the grains themselves possibly due to lower resistivities in the grain boundaries. The efficiency of the best solar cell obtained using the mc-Si metallurgical feedstock-I is 16.1%. It has been identified that the fast light induced degradation, whose magnitude is lower than that of a reference cell suggests the ...
2007-07-01
cap alpha. -2 adrenergic receptor: a radiohistochemical study
Energy Technology Data Exchange (ETDEWEB)
..cap alpha..-2 adrenergic agents have been shown to influence blood pressure, heart rate and other physiological and behavioral functions through interactions with adrenergic pathways within the central nervous system. Pharmacologically relevant ..cap alpha..-1 adrenergic receptors were biochemically characterized and radiohistochemically analyzed in intact tissue sections of the rat and human central nervous system. The anatomical distribution of the ..cap alpha..-2 receptors, labeled with the agonist (/sup 3/H)para-aminoclonidine, verified the concept that ..cap alpha..-2 receptors are closely associated with adrenergic nerve terminals and that ..cap alpha..-2 agents can influence autonomic and endocrine function through an action in the central nervous system. Since ..cap alpha..-2 agonists can influence sympathetic outflow, ..cap alpha..-2 binding sites were closely analyzed in the intermediolateral cell column of the ...
1984-01-01
The performance of 250 different computational protocols (combinations of density functionals, basis sets and methods) was assessed on a set of 165 well-established experimental (1)H-(1)H nuclear coupling constants (J(H-H)) from 65 molecules spanning a wide range of "chemical space". Thereby we found that, if one uses core-augmented basis sets and allows for linear scaling of the raw results, calculations of only the Fermi contact term yield more accurate predictions than calculations where all four terms that contribute to J(H-H) are evaluated. It turns out that B3LYP/6-31G(d,p)u+1s is the best (and, in addition, one of the most economical) of all tested methods, yielding predictions of J(H-H) with a root-mean-square deviation from experiment of less than 0.5 Hz for our test set. Another method that does similarly well, without the need for additional 1s basis functions, is B3LYP/cc-pVTZ, which is, however, ca. 8 times more "expensive" in ...
2011-05-16
Energy and CO{sub 2eq} analysis of the agricultural phase in the sunflower biodiesel chain
Energy Technology Data Exchange (ETDEWEB)
The suitability of the sunflower for biodiesel production was discussed in terms of the reference values on carbon dioxide equivalents (CO{sub 2eq}) emissions for every phase of the biofuels chain as indicated in the European Union (EU) Directive on renewable energies. A life cycle analysis performed on the agricultural phase of the sunflower showed that CO{sub 2eq} emissions from the cultivation phase exceeded the EU reference value. This paper highlighted the relevance of allocation methods to spread out energy consumption and CO{sub 2eq} emissions among sunflower biodiesel and oilcake. Allocation was made according to the principles of mass content, energy content and the economic value of co-products. The CO{sub 2eq} reductions obtained with the 3 methods were approximately 60, 50 and 25 per cent, respectively when compared to a case without allocation. Since these methods did not distinguish the different functionality of co-products in ...
2010-07-01
Thyroid Cathepsin K: Roles in Physiology and Thyroid Disease
British Library Electronic Table of Contents (United Kingdom)
The human genome encodes 11 cysteine cathepsins belonging to the papain-like family of cysteine peptidases that are known predominantly as endo-lysosomal enzymes. However, it is now understood that the functions and activities of cysteine cathepsins are not limited to endo-lysosomal compartments, as they are also active in the peri- and extracellular space. The thyroid gland is an endocrine organ where such intra- and extracellular proteolytic activities are required to solubilize the prohormone thyroglobulin from its luminal, covalently cross-linked storage forms for subsequent processing into smaller protein fragments and thyroid hormone liberation. Cathepsin K has been identified as one of the cysteine cathepsins with a crucial role in thyroglobulin processing. However, cathepsin K has ...
2011-01-01
The structure of molecular clouds - III. A link between cloud structure and star formation mode
British Library Electronic Table of Contents (United Kingdom)
Abstract We analyse extinction maps of nearby giant molecular clouds to forge a link between driving processes of turbulence and modes of star formation. Our investigation focuses on cloud structure in the column density range above the self-shielding threshold of 1-mag AV and below the star formation threshold - the regime in which turbulence is expected to dominate. We identify clouds with shallow mass distributions as cluster forming. Clouds that form stars in a less clustered or isolated mode show a steeper mass distribution. Structure functions prove inadequate to distinguish between clouds of different star formation mode. They may, however, suggest that the turbulence in the average cloud is governed by solenoidal forcing. The same is found using the -variance analysis which also in...
2011-01-01
Submitochondrial distribution of cAMP in its incubation with rat liver mitochondria
Energy Technology Data Exchange (ETDEWEB)
When labeled cAMP is incubated with isolated mitochondria from rat liver, it penetrates not only through the outer membrane of the mitochondria but also into the mitoplasts, where it is accumulated chiefly in the matrix. Damage to the mitochondrial membrane by freezing-thawing promotes not an influx but an efflux of cAMP out of the mitoplasts. A substantial part of the labeled nucleotide in all the investigated submitochondrial fractions was identified as intact cAMP by the method of thin-layer chromatography. The transport of cAMP into the mitochondria can explain the activation of their functions by the hormones that activate cytoplasmic adenylate cyclase and by extramitochondrial (cytosol) cAMP, as well as the presence of cAMP-dependent protein kinase and cAMP-phosphodiesterase in the mitochondria.
1986-03-20
Energy Technology Data Exchange (ETDEWEB)
The relationship between microstructure and macro properties of different cementitious materials has been investigated. This study consists of the following tasks: using NMR and IR to better characterize the amorphous and poorly crystalline phases that occur in blended cements; characterizing the microstructure of the hydration products of modified Portland cement as a function of different percentages of pozzolan replacements by ESEM, SEM, and EDS; comparing the properties of blended cement pastes with a control group of normal Portland cements; and studying the engineering aspects of blended cement that are important for identifying and characterizing fundamental phenomena that are responsible for their durability. The overall influence of the nanoscale and microscale structure of blended and Portland cement on the properties of the resultant composite will be discussed.
1997-10-01
This paper deals with the experimental identification and the validation of a non-parametric probabilistic approach allowing model uncertainties and data uncertainties to be taken into account in the numerical model developed to predict low- and medium-frequency dynamics of structures. The analysis is performed for a composite sandwich panel representing a complex dynamical system which is sufficiently simple to be completely described and which exhibits, not only data uncertainties, but above all model uncertainties. The dynamical identification is experimentally performed for eight panels. The experimental frequency response functions are used to identify the non-parametric probabilistic approach of model uncertainties. The prediction of the low- and medium-frequency dynamical responses obtained with the stochastic system is compared with the experimental measurements.
2006-06-01
Prediction of the naturalisation potential and weediness risk of transgenic cotton in Australia
British Library Electronic Table of Contents (United Kingdom)
Climex climate-matching and inferential-modelling was used to examine the naturalisation potential of genetically modified and non-transgenic Upland Cotton (Gossypium hirsutum variety hirsutum) in Australia north of latitude 22degreeS. The Climate-Match (CM) function was used to identify locations in north-east Australia where climate matches (CM Index>0.7) the experimental sites of Eastick [Eastick, R., 2002. The Potential Weediness of Transgenic Cotton in Northern Australia. Northern Territory Department of Business, Industry and Resource Development Technical Bulletin No. 305 (Internet resource: http://cotton.pi.csiro.au/Assets/PDFFiles/TB3051.pdf)] in north-west Australia. Most of Australia north of 22degreeS had climate matching one or more of the sites of Eastick (2002), locations wh...
2007-01-01
Pigpen, a nuclear coiled body component protein, is involved in angiogenesis
British Library Electronic Table of Contents (United Kingdom)
We previously reported that puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) is required for vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis and for endothelial differentiation from embryonic stem (ES) cells via the aminopeptidase activity of PILSAP. In this study, we searched for molecules that function during angiogenesis with PILSAP. We performed proteome analysis of nuclear extracts from embryoid bodies (EBs) made from ES cells transfected with mutant PILSAP lacking aminopeptidase activity and mock EBs. We identified pigpen, a 67-kDa nuclear coiled body component protein. Immunoprecipitation and western blotting demonstrated the binding of PILSAP and pigpen in endothelial cells (ECs), and this interaction was enhanc...
2010-01-01
Penile rehabilitation therapy following radical prostatectomy is a much debated topic. Erectile dysfunction is still a significant contributor to postoperative morbidity following radical prostatectomy, despite meticulous nerve-sparing technique. Secondary smooth muscle changes in the penis have been identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and fibrosis. Initial observations that intracavernous injection therapies used on a regular basis postoperatively resulted in improvements in the return of spontaneous erectile function led to the development of penile rehabilitation protocols. Chronic dosing of PDE-V inhibitors is now commonly used by urologists after radical prostatectomy. Despite the current enthusiasm of penile rehabilitation therapy, current scientific evidence with clinical trials is still limited. PMID:19255627
2009-01-25
British Library Electronic Table of Contents (United Kingdom)
In this paper we review and classify the various patterns of isosteric heat versus loading for adsorption of gases on graphitised thermal carbon black at temperatures ranging from below the 3D triple point to temperatures above it, but less than the 3D critical point. We have identified the features of heat curve and highlighted the microscopic origin of these features. The patterns vary with temperature and with the relative strength of the fluid-fluid interaction and solid-fluid interaction. For simple adsorptives (by simple we meant there is no strong association between fluid particles), the heat curve is typified by fluid-fluid attraction and layering phenomena. For adsorptives showing strong association such as water, ammonia and methanol, the heat curve essentially begins below the ...
2008-01-01
Nonverbal Learning Disability explained: the link to shunted hydrocephalus
British Library Electronic Table of Contents (United Kingdom)
Accessible summary - -Children with a Nonverbal Learning Disability (NLD) resulting from shunted hydrocephalus and spina bifida face many difficulties not experienced by those with a language learning disability. - -As they grow older and more autonomy is expected, friendships became harder to sustain and daily life can be full of fear if the nonverbal learning disability is not identified and managed. - -This paper explains the theorised cause of nonverbal learning disability - damage to right hemisphere white matter or myelin. - -Damage is believed to cause problems with planning, organisation, time management, problem-solving, decision-making and friendships, and the mismatch with articulate speech and a good vocabulary causes a functional profile that is difficult for educationists or ...
2011-01-01
Nearly Conformal QCD and AdS/CFT
Energy Technology Data Exchange (ETDEWEB)
The AdS/CFT correspondence is a powerful tool to study the properties of conformal QCD at strong coupling in terms of a higher dimensional dual gravity theory. The power-law falloff of scattering amplitudes in the non-perturbative regime and calculable hadron spectra follow from holographic models dual to QCD with conformal behavior at short distances and confinement at large distances. String modes and fluctuations about the AdS background are identified with QCD degrees of freedom and orbital excitations at the AdS boundary limit. A description of form factors in space and time-like regions and the behavior of light-front wave functions can also be understood in terms of a dual gravity description in the interior of AdS.
2005-08-08
Mechanisms of obesity-induced male infertility
British Library Electronic Table of Contents (United Kingdom)
Male infertility, characterized by hypogonadism, decreased semen quality or ejaculatory dysfunction, accounts for approximately 20% of infertility cases. Obesity and metabolic dysfunction have been identified, among other causal factors, to contribute to male infertility. In the context of the Western world's `obesity epidemic', this article discusses three main biological mechanisms linking obesity to impaired male reproductive function: hypogonadism, testicular heat stress/hypoxia-induced apoptosis and endocrine disruption by `obesogens'. Among these, obesity-induced hypogonadism is undoubtedly the most clinically significant and is easily assessed. Rapidly expanding areas of research in this area include leptin modulation of kisspeptins and hypothalamic-pituitary-testicular hormone path...
2010-01-01
Low frequency noise from MW wind turbines -- mechanisms of generation and its modeling
Energy Technology Data Exchange (ETDEWEB)
During the present project the mechanisms of generation of low frequency noise (LFN) for upwind rotors has been investigated. A 3.6 MW turbine has been simulated with a noise prediction model from NASA in US. Running the model on this turbine a number of important turbine design parameters with influence on the LFN have been identified as well as other parameters not linked to the turbine design. Of important parameters can be mentioned 1) rotor rotational speed, 2) blade/tower clearance, 3) rotor configuration - upwind/downwind, 4) unsteadiness/turbulence in inflow. Further, the directivity characteristics of LFN has been computed as well as reduction in noise as function of distance from the turbine. In general low levels of LFN has been computed for the upwind rotor in standard configuration. (au)
2008-04-15
British Library Electronic Table of Contents (United Kingdom)
Perceptions of sensation and pain in healthy people are believed to be the net result of sensory input and descending modulation from brainstem and cortical regions depending on emotional and cognitive factors. Here, the influence of attention on neural activity in the spinal cord during thermal sensory stimulation of the hand was investigated with functional magnetic resonance imaging by systematically varying the participants' attention focus across and within repeated studies. Attention states included (1) attention to the stimulus by rating the sensation and (2) attention away from the stimulus by performing various mental tasks of watching a movie and identifying characters, detecting the direction of coherently moving dots within a randomly moving visual field and answering mentally-...
2011-01-01
Hyaluronate synthesis by synovial villi in organ culture. [Dogs
Energy Technology Data Exchange (ETDEWEB)
Individual canine synovial villi were used to establish short-term synovial organ cultures. These villi incorporated /sup 3/H-glucosamine into highly-polymerized /sup 3/H-hyaluronic acid (/sup 3/H-HA), which was the only /sup 3/H-glycosaminoglycan identified in the culture medium. Some /sup 3/H-HA, and larger amounts of other /sup 3/H-glycosaminoglycans, were recovered from cultured tissues. Culture medium /sup 3/H-HA content was proportional to the surface area of cultured villi. Organ cultures of nonvillous synovium were compared with villi; nonvillous cultures synthesized less /sup 3/H-HA per mm2 of their synovial intimal surface than villi. These cultures complement cell culture techniques for in vitro studies of synovial lining cell function.
1983-06-01
Hot Cell Facility (HCF) Safety Analysis Report
Energy Technology Data Exchange (ETDEWEB)
This Safety Analysis Report (SAR) is prepared in compliance with the requirements of DOE Order 5480.23, Nuclear Safety Analysis Reports, and has been written to the format and content guide of DOE-STD-3009-94 Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Safety Analysis Reports. The Hot Cell Facility is a Hazard Category 2 nonreactor nuclear facility, and is operated by Sandia National Laboratories for the Department of Energy. This SAR provides a description of the HCF and its operations, an assessment of the hazards and potential accidents which may occur in the facility. The potential consequences and likelihood of these accidents are analyzed and described. Using the process and criteria described in DOE-STD-3009-94, safety-related structures, systems and components are identified, and the important safety functions of each SSC are described. Additionally, information which describes the safety management programs at ...
2000-11-01
British Library Electronic Table of Contents (United Kingdom)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquious in the environment both as natural products and as environmental contaminants. Among PAHs, phenanthrene (PH) that is ubiquitously distributed throughout the environment was subjected in this study. Although environmental distribution and metabolism of PH have been well reported, there are only a few studies examined the expression of mRNA and their functions on PH-induced toxicity. A new paradigm in toxicity screening, toxicogenomic technology represents a useful approach for evaluating the toxic properties of environmental pollutants. In this respect, we elicited the genes which were changed more than 2-fold by analysis of gene expression profiles in human hepatocellular carcinoma (HepG2) cells, exposed to PH by using human oligonucleo...
2011-01-01
Fingerprint testing of contaminated ventilation extract filter systems at Sizewell B
International Nuclear Information System (INIS)
Sizewell B is Nuclear Electric's latest power station, and the Pressurised Water Reactor (PWR) design on which it is based represents a ''first'' for the UK. One of the integral components of the plant is the heating, ventilation and air-conditioning (HVAC) system, which performs a contamination control and gaseous waste management function for the site. During the commissioning of Sizewell B Power Station the extract systems of the HVAC plant underwent a procedure known as ''fingerprinting''. This entailed the characterisation of the facilities provided to test the filtration plant during its lifetime. The assessment of their adequacy was then used to identify necessary modifications and/or to propose the manner in which future in situ performance testing would be carried out. The paper outlines the basic principles and procedure that was used to ''fingerprint'' test systems during the commissioning of Sizewell B. A specific example is ...
Energy Technology Data Exchange (ETDEWEB)
The transmission of electrical energy by use of underground cables is increasing. Fault location techniques have certain limitations; incipient fault detection and location would help reduce the maintenance cost of these lines as well as improve the reliability of service. The report discusses some test results related to RF-probing techniques applied to high-voltage transmission lines. The high-frequency losses and attenuation in high-voltage cables places certain ultimate limitations on RF-probing techniques for incipient fault detection. Time-domain reflectrometry methods were employed to assess the RF-transmission properties of high-voltage cables at frequencies as high as 6 GHz. Fast-Fourier-transform deconvolution was used to obtain loss measurements as a function of frequency. The loss mechanisms were identified. The measurement hardware and methods are discussed as well as analysis approach leading to the conclusions.
1986-04-01
British Library Electronic Table of Contents (United Kingdom)
Erythroid differentiation regulator (Erdr1) was first discovered in mouse leukemia cell lines and functions as a stress-related survival factor. This study investigated whether Erdr1 regulates murine melanoma progression, as well as the mechanism involved in Erdr1-regulated metastasis. The expression of Erdr1 is negatively correlated with IL-18 expression, which has a pro-cancer effect in melanoma. To study the role of Erdr1 as an anti-cancer factor, cell migration, invasion, and proliferation were measured. Erdr1 overexpression markedly inhibited the level of cell migration, invasion, and proliferation in B16F10 cells in vitro. In addition, Erdr1 overexpression significantly suppressed melanoma lung colonization, metastasis, and tumor growth in vivo. To identify the factors involved in Er...
2011-01-01
Dirichlet mean identities and laws of a class of subordinators
An interesting line of research is the investigation of the laws of random variables known as Dirichlet means. However, there is not much information on interrelationships between different Dirichlet means. Here, we introduce two distributional operations, one of which consists of multiplying a mean functional by an independent beta random variable, the other being an operation involving an exponential change of measure. These operations identify relationships between different means and their densities. This allows one to use the often considerable analytic work on obtaining results for one Dirichlet mean to obtain results for an entire family of otherwise seemingly unrelated Dirichlet means. Additionally, it allows one to obtain explicit densities for the related class of random variables that have generalized gamma convolution distributions and the finite-dimensional distribution of their associated L\\'{e}vy processes. The importance of ...
2010-01-01
Deformations of topological open strings
International Nuclear Information System (INIS)
Deformations of topological open string theories are described, with an emphasis on their algebraic structure. They are encoded in the mixed bulk-boundary correlators. They constitute the Hochschild complex of the open string algebra - the complex of multilinear maps on the boundary Hilbert space. This complex is known to have the structure of a Gerstenhaber algebra (Deligne theorem), which is also found in closed string theory. Generalising the case of function algebras with a B-field, we identify the algebraic operations of the bulk sector, in terms of the mixed correlators. This gives a physical realisation of the Deligne theorem. We translate to the language of certain operads (spaces of d-discs with gluing) and d-algebras, and comment on generalisations, notably to the AdS/CFT correspondence. The formalism is applied to the topological A- and B-models on the disc. (author)
2001-01-01
Creep performance and microstructure of the iron alloy Alloy 800 HT
International Nuclear Information System (INIS)
The examination of the high-temperature properties of the alloy Alloy 800HT has shown that both the creep performance and the microstructure of the material can be purposefully set by the initial heat treatment. At the high temperatures applied, (700-900 C), a rapid softening process sets in induced by carbide precipitation, stabilization, and coarsening. This softening process causes creep velocities strongly accelerating as a function of duration of the heat treatment prior to the creep test. The identified cause of the softening effect is a change in particle size that could be verified by SEM and TEM. It is shown that two different carbide precipitate size classes are responsible for the softening effect. While the precipitates dectable by TEM become effective primarily via interactions with dislocations, the carbide precipitates detectable only by SEM contribute to a hardening of the grain boundaries and the matrix.(orig./CB)
1997-11-28
Cloning and characteristics of Brn1 gene in Curvularia lunata causing leaf spot in maize
British Library Electronic Table of Contents (United Kingdom)
The full length cDNA of the Brn1 was first cloned, and then expression of the Brn1 was analyzed and the function was identified by silencing technology. Results show that the full length cDNA of the C. lunata Brn1 gene contains 1001 base pairs and an 801?bp open reading frame encoding 267 amino acids. Semi-quantitative PCR analysis shows that the expression of Brn1 at 96?h is significantly higher than at 24 and 72?h (p?Brn1-silenced transformants were light brown in culture filtrate, and have significantly reduced toxin production relative to the wild-type. These results imply that Brn1 gene in C. lunata is not only involved in 1,8-dihydroxynaphthalene melanin synthesis, but is also relatively associated with toxin biosynthesis of the pathogen.
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
Human activities in the karst Ozark Plateaus can impact water quality of springs where surface water is rapidly transferred to subsurface conduits. Bennett Spring, in southern Missouri, is the fourth largest spring in the state and supports local tourism activities. Questions regarding poorly functioning on-site wastewater systems (OWS) have raised concerns over the long-term water quality of the spring. This study reports the results of a surface water quality monitoring program in the recharge area where monthly samples were collected at base flow to identify potential pollution sources to the spring. Base flow hydrology of the recharge area was highly variable over the study period, which was drier than normal, causing an incomplete sampling record due to no flow conditions at some site...
2011-01-01
Averting problems caused by solutions
International Nuclear Information System (INIS)
A brief overview is given of a report on Emergency Core Cooling Systems (ECCS) Recirculation Reliability Knowledge Base compiled by the International Working Group on ECCS Reliability for the OECD/NEA/CSNI. Four safety issues are identified which arise in the context of loss of coolant accidents (LOCAs) and are connected with materials and/or processes that interfere with the ECCS safety function in ways other than just strainer head loss generation. They are: the generation of missiles during a LOCA from encapsulated insulation materials used to reduce insulation debris production; clogging of BWR pressure suppression containment vent pipes by insulation jackets or metallic insulation foil pieces; strainer or sump debris ingestion and the effects of ingested debris on ECCS equipment and core cooling; miscellaneous items such as material aging and self-cleaning strainer concepts. The emphasis is mainly on BWRs but many of the considerations ...
Analysis of installation damage tests for LRFD calibration of reinforced soil structures
British Library Electronic Table of Contents (United Kingdom)
North American design codes are now committed to the development of load and resistance factor design (LRFD) for reinforced soil structures including internal stability limit states. Reliability-based analysis is required to carry out these calibrations. A framework for LRFD calibration has been proposed by the writers that requires bias statistics for load and resistance terms for each limit state function. In this paper the formulation of the limit state for reinforcement tensile rupture is developed and the component strength-reduction bias statistics identified. The paper describes how to compute bias statistics from project-specific installation damage trials for use in reliability-based design for the reinforcement rupture limit state or using data from multiple sources for LRFD cali...
2011-01-01
Adrenal incidentaloma: Does an adequate workup rule out surprises?
British Library Electronic Table of Contents (United Kingdom)
Background Adrenal incidentaloma remains a diagnostic challenge. Despite well-established management guidelines, the long-term results of following these guidelines are unknown. We sought to determine how accurately these guidelines identify functioning incidentalomas and how often these guidelines result in adrenalectomy for benign tumors. Methods We catalogued adrenal incidentalomas from a retrospective review of 500 consecutive adrenalectomies at a single institution. The outcome measures studied were patient demographics, preoperative biochemical analysis, imaging characteristics, tumor size, type of operation performed, and postoperative histologic diagnosis. Results Eighty-one of the 500 adrenalectomies performed were for incidentalomas. Size was the only significant characteristic t...
2010-01-01
Scientific Electronic Library Online (English)
Abstract in english Functional properties of soy proteins for food are closely related to the composition of their storage protein subunits. Using base excision sequence scanning (BESS), we show that the absence of the A4 peptide in the G4 glycinin subunit of the soybean (Glycine max L.) cultivar Enrei was caused by the same point mutation in the Gy4 gene as previously reported in the soybean cultivar Raiden. Although the genetic relationship between Raiden and Enrei is not known, the same p (more) oint mutation in their Gy4 genes may indicate that they probably share a related origin. The application of BESS to identify single nucleotide polymorphisms (SNPs) as co-dominant markers for marker-assisted selection (MAS) of a recessive null allele is also discussed.
2005-09-01
Performance Assessment of Wolsung Unit 2 Safety Grade Pumps using In-Service Test
Energy Technology Data Exchange (ETDEWEB)
Nuclear power plant has several safety features and each safety feature is based on the operation of pumps and valves. Therefore, it is an essential basis for the safety of nuclear power plant to keep operational readiness of pumps and valves by In-Service Test (IST). According to Ministry of Education, Science and Technology (MEST) Bulletin 2008-14, the safety functioned pumps and valves of all nuclear power plants of Korea Hydro and Nuclear Power Co. Ltd.(KHNP) have been tested to verify their performance of safety function. Each safety grade pump has own design requirement and should be tested to identify whether it could meet the requirement. Design requirements and test references of all safety grade pumps of Wolsung Nuclear Power Plant Unit 2 (Wolsung Unit 2) were examined in this study. And the results of the performance test of the pump were also compared to the design requirements of each pump.
2008-10-15
Performance Assessment of Wolsung Unit 2 Safety Grade Pumps using In-Service Test
International Nuclear Information System (INIS)
Nuclear power plant has several safety features and each safety feature is based on the operation of pumps and valves. Therefore, it is an essential basis for the safety of nuclear power plant to keep operational readiness of pumps and valves by In-Service Test (IST). According to Ministry of Education, Science and Technology (MEST) Bulletin 2008-14, the safety functioned pumps and valves of all nuclear power plants of Korea Hydro and Nuclear Power Co. Ltd.(KHNP) have been tested to verify their performance of safety function. Each safety grade pump has own design requirement and should be tested to identify whether it could meet the requirement. Design requirements and test references of all safety grade pumps of Wolsung Nuclear Power Plant Unit 2 (Wolsung Unit 2) were examined in this study. And the results of the performance test of the pump were also compared to the design requirements of each pump.
2008-10-01
Neural-network-based voice-tracking algorithm
A voice-tracking algorithm was developed and tested for the purposes of electronically separating the voice signals of simultaneous talkers. Many individuals suffer from hearing disorders that often inhibit their ability to focus on a single speaker in a multiple speaker environment (the cocktail party effect). Digital hearing aid technology makes it possible to implement complex algorithms for speech processing in both the time and frequency domains. In this work, an average magnitude difference function (AMDF) was performed on mixed voice signals in order to determine the fundamental frequencies present in the signals. A time prediction neural network was trained to recognize normal human voice inflection patterns, including rising, falling, rising-falling, and falling-rising patterns. The neural network was designed to track the fundamental frequency of a single talker based on the training procedure. The output of the neural network can be used to design an ...
2002-11-01
Maintenance Implementation Plan for solid waste
Energy Technology Data Exchange (ETDEWEB)
This Maintenance Implementation Plan (MIP) has been developed for. implementation of the US Department of Energy (DOE) Order 4330.4A. Maintenance Implementation Program (DOE 1990) at the Hanford Site Solid Waste complex. It addresses maintenance functions associated with Solid Waste Management, which includes the field operational group and the facilities operational group. An assessment of the existing maintenance programs for Solid Waste was performed, and the results of this assessment were evaluated to determine corrective actions required to bring Solid Waste Maintenance into compliance with the order. The MIP assessment disclosed that most elements defined in the order are currently implemented for Solid Waste. It also identified issues which must be addressed to bring the maintenance function into full compliance with DOE Order 4330.4A. These include documentation of the maintenance training program, expanded scope ...
1992-06-01
Energy Technology Data Exchange (ETDEWEB)
Homology analyses of the protein sequences of chicken liver and rat mammary gland fatty acid synthases were carried out. The amino acid sequences of the chicken and rat enzymes are 67% identical. If conservative substitutions are allowed, 78% of the amino acids are matched. A region of low homologies exists between the functional domains, in particular around amino acid residues 1059-1264 of the chicken enzyme. Homologies between the active sites of chicken and rat and of chicken and yeast enzymes have been analyzed by an alignment method. A high degree of homology exists between the active sites of the chicken and rat enzymes. However, the chicken and yeast enzymes show a lower degree of homology. The DADPH-binding dinucleotide folds of the {beta}-ketoacyl reductase and the enoyl reductase sites were identified by comparison with a known consensus sequence for the DADP- and FAD-binding dinucleotide folds. The active sites of all of the enzymes ...
1989-11-01
Gear fault detection using customized multiwavelet lifting schemes
Fault symptoms of running gearboxes must be detected as early as possible to avoid serious accidents. Diverse advanced methods are developed for this challenging task. However, for multiwavelet transforms, the fixed basis functions independent of the input dynamic response signals will possibly reduce the accuracy of fault diagnosis. Meanwhile, for multiwavelet denoising technique, the universal threshold denoising tends to overkill important but weak features in gear fault diagnosis. To overcome the shortcoming, a novel method incorporating customized (i.e., signal-based) multiwavelet lifting schemes with sliding window denoising is proposed in this paper. On the basis of Hermite spline interpolation, various vector prediction and update operators with the desirable properties of biorthogonality, symmetry, short support and vanishing moments are constructed. The customized lifting-based multiwavelets for feature matching are chosen by the minimum entropy ...
2010-07-01
Feasibility study of large combined function magnets for the Jefferson lab 12 GeV upgrade
The 12 GeV upgrade at Jefferson Lab has identified two new large spectrometers as Physics detectors for the project. The first is a 7.5 Gev/c 35 m-sr. spectrometer that requires a pair of identical Combined Function Superconducting Magnets (CFSM) that can simultaneously produce 1.5 T dipole fields and 4.5 T/m quadrupole fields inside a warm bore of 120cm. The second is an 11 GeV/c 2 m-sr. spectrometer that requires a CFSM that simultaneously produces a dipole field of 4.0 T and a quadruple field of 3.0 T/m in a 60 cm warm bore. Magnetic designs using TOSCA 3D have been performed to realize the magnetic requirements, provide 3d fields for optics analysis and produce field and force information for the engineering feasibility of the magnets. A two-sector cos( theta )/cos(2 theta ) design with a low nominal current density, warm bore and warm iron design has been selected and analyzed. These low current densities are consistent with the limits for ...
2005-01-01
EVIDENCE FOR DELAYED MASSIVE STAR FORMATION IN THE M17 PROTO-OB ASSOCIATION
International Nuclear Information System (INIS)
Through analysis of archival images and photometry from the Spitzer GLIMPSE and MIPSGAL surveys combined with Two Micron All Sky Survey and MSX data, we have identified 488 candidate young stellar objects (YSOs) in the giant molecular cloud M17 SWex, which extends #approx#50 pc southwest from the prominent Galactic H II region M17. Our sample includes >200 YSOs with masses >3 M _s_u_n that will become B-type stars on the main sequence. Extrapolating over the stellar initial mass function (IMF), we find that M17 SWex contains >1.3 x 10"4 young stars, representing a proto-OB association. The YSO mass function is significantly steeper than the Salpeter IMF, and early O stars are conspicuously absent from M17 SWex. Assuming M17 SWex will form an OB association with a Salpeter IMF, these results reveal the combined effects of (1) more rapid circumstellar disk evolution in more massive YSOs and (2) delayed onset of ...
2010-05-10
Energy Technology Data Exchange (ETDEWEB)
Two-phase pressure drop and fluctuating static pressures were measured in a small horizontal rectangular channel (hydraulic diameter = 5.44 mm). The two-phase fluid was an air/water mixture at atmospheric pressure tested over a mass flux range of 50 to 2,000 kg/m[sup 2] [center dot] s. Two-phase flow patterns were identified and an objective method was found for determining the flow pattern transition from bubble or plug flow to slug flow. The method is based on an RMS static pressure measurement. In particular, it is shown that the transition is accompanied by a clear and abrupt increase in the RMS pressure when plotted as a function of mass quality. Use of the RMS pressure as a two-phase flow pattern transition indicator is shown to have advantages over pressure-versus-time trace evaluations reported in the literature. The transition is substantiated by a clear local change in slope in the curve of two-phase pressure drop plotted as a ...
1994-03-01
Energy Technology Data Exchange (ETDEWEB)
During this project we experimentally evaluated the below-ground biomass and carbon allocation and partitioning of four different fast- and slow-growing families of loblolly pine located in Scotland County, NC, in an effort to increase the long-term performance of the crop. The trees were subjected to optimal nutrition and control since planting in 1993. Destructive harvests in 1998 and 2000 were used for whole?plant biomass estimates and to identify possible family differences in carbon acquisition (photosynthesis) and water use efficiency. At regular intervals throughout each year we sampled tissues for carbohydrate analyses to assess differences in whole-tree carbon storage. Mini rhizotron observation tubes were installed to monitor root system production and turnover. Stable isotope analysis was used to examine possible functional differences in water and nutrient acquisition of root systems between the various families. A genetic ...
2001-03-01
The Application of Spatial Signature Analysis to Electrical Test Data: Validation Study
Energy Technology Data Exchange (ETDEWEB)
This paper presents the results of the Spatial Signature Analysis (SSA) Electrical-test (e-test) validation study that was conducted between February and June, 1998. SSA is an automated procedure developed by researchers at the Oak Ridge National Laboratory to address the issue of intelligent data reduction while providing feedback on current manufacturing processes. SSA was initially developed to automate the analysis of optical defect data. Optical defects can form groups, or clusters, which may have a distinct shape. These patterns can reveal information about the manufacturing process. Optical defect SSA uses image processing algorithms and a classifier system to interpret and identify these patterns, or signatures. SSA has been extended to analyze and interpret electrical test data. The algorithms used for optical defect SSA have been adapted and applied to e-test binmaps. An image of the binmap is created, and features such as geometric and invariant moments ...
1999-03-15
Telecommunications Network Plan
International Nuclear Information System (INIS)
The Office of Civilian Radioactive Waste Management (OCRWM) must, among other things, be equipped to readily produce, file, store, access, retrieve, and transfer a wide variety of technical and institutional data and information. The data and information regularly produced by members of the OCRWM Program supports, and will continue to support, a wide range of program activities. Some of the more important of these information communication-related activities include: supporting the preparation, submittal, and review of a license application to the Nuclear Regulatory Commission (NRC) to authorize the construction of a geologic repository; responding to requests for information from parties affected by and/or interested in the program; and providing evidence of compliance with all relevant Federal, State, local, and Indian Tribe regulations, statutes, and/or treaties. The OCRWM Telecommunications Network Plan (TNP) is intended to identify, as ...
1997-10-07
International Nuclear Information System (INIS)
The Mizunami Underground Research Laboratory (MIU) of the Japan Atomic Energy Agency is a major site for geoscientific research to advance the scientific and technological basis for geological disposal of high-level radioactive waste in crystalline rock. Studies on relevant engineering technologies in the MIU consist of a) research on design and construction technology for very deep underground applications, and b) research on engineering technology as a basis of geological disposal. In the Second Phase of the MIU project (the construction phase), engineering studies have focused on research into design and construction technologies for deep underground. The main subjects in the study of very deep underground structures consist of the following: 'Demonstration of the design methodology', 'Demonstration of existing and supplementary excavation methods', 'Demonstration of countermeasures during excavation' and 'Demonstration of safe construction'. In the FY 2007 ...
2008-07-01
Pipeline risk assessment and risk management
Energy Technology Data Exchange (ETDEWEB)
The objective of this work group was to identify obstacles to the development of better risk management practices and performance standards in the pipeline industry. An outline of developments in pipeline risk assesment management was presented, including an update of the Risk Based Design and Assessment annex and other CSA Z662 code developments. It was suggested that progress in risk management require that acceptable levels of risk and reliability need to be defined. Environmental and safety consequence analysis was recommended, as well as failure frequency estimation and assessment of distribution systems. Guidelines for Integrity Management Programs (IMPs) were reviewed. It was noted that CSA Z662 will become mandatory for sour gas in 2005 and may become mandatory for all onshore pipelines in 2007. Operating company procedures in relation to hazards with significant consequences were discussed. It was noted that companies should assess risks associated with ...
2005-07-01
Oak Ridge National Laboratory Core Competencies
Energy Technology Data Exchange (ETDEWEB)
A core competency is a distinguishing integration of capabilities which enables an organization to deliver mission results. Core competencies represent the collective learning of an organization and provide the capacity to perform present and future missions. Core competencies are distinguishing characteristics which offer comparative advantage and are difficult to reproduce. They exhibit customer focus, mission relevance, and vertical integration from research through applications. They are demonstrable by metrics such as level of investment, uniqueness of facilities and expertise, and national impact. The Oak Ridge National Laboratory (ORNL) has identified four core competencies which satisfy the above criteria. Each core competency represents an annual investment of at least $100M and is characterized by an integration of Laboratory technical foundations in physical, chemical, and materials sciences; biological, environmental, and social ...
1994-12-01
Methods and results for calibration and track separation of a GEM based TPC using an UV-laser
Energy Technology Data Exchange (ETDEWEB)
In the last 30 years high energy physics could write an impressive story of success. Since the introduction of the Standard Model (SM), it has met every experimental test. However the final confirmation has to prove the mechanism of electroweak symmetry breaking, which could not be confirmed yet. The most favored theory, which includes the introduction of a Higgs field, could not be verified experimentally. Furthermore there is clear evidence, that the SM is only a low energy description of nature and its principles, as the SM describes only 4 % of the known matter in the universe. There are two different approaches in accelerator driven high energy physics to clarify the open questions. The Large Hadron Collider (LHC) have a good opportunity to measure some of the missing pieces with its high center of mass energy. The International Linear Collider (ILC) will then measure their parameters with high precision. To guarantee this high precision the detectors have to be able to ...
2008-12-15
Data interpretation in nuclear forensics
International Nuclear Information System (INIS)
Nuclear Forensics is a key element in the response process which is initiated after detection of illicit nuclear or other radioactive material. Credible nuclear forensics relies on appropriate sampling procedures, on validated analytical methods and on thorough data analysis and interpretation. Nuclear forensics aims at providing clues on the history and the potential origin of the material. Elemental and isotopic composition of the material, as well as its macroscopic and microscopic appearance reflect the technological processes used for the fabrication of the material. The nuclear forensic analysis first of all results in measurement data. Through appropriate processing of these data information on the nature and the history of the material can be obtained. A number of data evaluation techniques serving this purpose are conceivable and have been applied. On the one side, statistical methods like principal component analysis (PCA) or classification and regression trees (CART) can be ...
Energy Technology Data Exchange (ETDEWEB)
High-resolution neutron capture cross section measurements of 55Mn were recently performed at GELINA by Schillebeeckx et al. (2005) and at ORELA by Guber et al. (2007). The analysis of the experimental data was performed with the computer code SAMMY using the Bayesian approach in the resonance parameters representation of the cross sections. The neutron transmission data taken in 1988 by Harvey et al. (2007) and not analyzed before were added to the SAMMY experimental data base. More than 95% of the s-wave resonances and more than 85% of the p-wave resonances were identified in the energy range up to 125 keV, leading to the neutron strength functions S0 = (3.90 0.78) x 10-4 and S1 = (0.45 0.08) x 10-4. About 25% of the d-wave resonances were identified with a possible strength function of S2 = 1.0 x 10-4. The capture cross section calculated at 0.0253 eV is 13.27 b, and the capture resonance integral is ...
2008-05-01
We present the draft genome sequence and its analysis for Fusobacterium nucleatum sub spp. vincentii (FNV), and compare that genome with F. nucleatum ATCC 25586 (FN). A total of 441 FNV open reading frames (ORFs) with no orthologs in FN have been identified. Of these, 118 ORFs have no known function and are unique to FNV, whereas 323 ORFs have functional orthologs in other organisms. In addition to the excretion of butyrate, H2S and ammonia-like FN, FNV has the additional capability to excrete lactate and aminobutyrate. Unlike FN, FNV is likely to incorporate galactopyranose, galacturonate, and sialic acid into its O-antigen. It appears to transport ferrous iron by an anaerobic ferrous transporter. Genes for eukaryotic type serine/threonine kinase and phosphatase, transpeptidase E-transglycosylase Pbp1A are found in FNV but not in FN. Unique ABC transporters, cryptic phages, and three types of restriction-modification ...
2003-06-01
BackgroundBiodiesel or ethanol derived from lipids or starch produced by microalgae may overcome many of the sustainability challenges previously ascribed to petroleum-based fuels and first generation plant-based biofuels. The paucity of microalgae genome sequences, however, limits gene-based biofuel feedstock optimization studies. Here we describe the sequencing and de novo transcriptome assembly for the non-model microalgae species, Dunaliella tertiolecta, and identify pathways and genes of importance related to biofuel production.ResultsNext generation DNA pyrosequencing technology applied to D. tertiolecta transcripts produced 1,363,336 high quality reads with an average length of 400 bases. Following quality and size trimming, ~ 45% of the high quality reads were assembled into 33,307 isotigs with a 31-fold coverage and 376,482 singletons. Assembled sequences and singletons were subjected to BLAST similarity searches and annotated with Gene Ontology (GO) and ...
2011-03-14
Energy Technology Data Exchange (ETDEWEB)
The most relevant aspects of research and service experience with environmentally-assisted cracking (EAC) of carbon (C) and low-alloy steels (LAS) in high-temperature (HT) water are reviewed, with special emphasis on the primary pressure boundary components of boiling water reactors (BWRs). The main factors controlling the susceptibility to EAC under light water reactor (LWR) conditions are discussed with respect to crack initiation and crack growth. The adequacy and conservatism of the current BWRVIP-60 stress corrosion cracking (SCC) disposition lines (DLs), ASME III fatigue design curves, and ASME XI reference fatigue crack growth curves, as well as of the GE EAC crack growth model are evaluated in the context of recent research results. The operating experience is summarized and compared to the experimental/mechanistic background knowledge. Finally, open questions and possible topics for further research are identified. Laboratory ...
2005-11-15
Development of a computerized portal verification scheme for pelvic treatment fields
International Nuclear Information System (INIS)
Purpose/Objective: At present, treatment verification between portal and reference images is performed based on manually-identified features by radiation oncologist, which is both time-consuming and potentially error-prone. There is a demand for the computerized verification procedure in clinical application. The purpose of this study is to develop a computerized portal verification scheme for pelvic treatment fields. Materials/Methods: The automated verification system involves image acquisition, image feature extraction, feature matching between reference and portal images and quantitative evaluation of patient setup. Electronic portal images with a matrix size of 256 x 256 and 12 bit gray levels were acquired using a liquid matrix electronic portal imaging device. Simulation images were acquired by digitizing simulation films using a TV camera into images with 256 x 256 matrix and 8 bit gray levels. Initially a Canny edge detector is applied to ...
1996-09-01
Energy Technology Data Exchange (ETDEWEB)
Research activity during the 1991--1992 funding period has been concerned with the following topics relevant to carbon monoxide activation. (1) Exploratory studies of water gas shift catalysts heterogenized on polystyrene based polymers. (2) Mechanistic investigation of the nucleophilic activation of CO in metal carbonyl clusters. (3) Application of fast reaction techniques to prepare and to investigate reactive organometallic intermediates relevant to the activation of hydrocarbons toward carbonylation and to the formation of carbon-carbon bonds via the migratory insertion of CO into metal alkyl bonds.
1992-06-04
Studies relevant to the catalytic activation of carbon monoxide
Energy Technology Data Exchange (ETDEWEB)
Research activity during the 1991--1992 funding period has been concerned with the following topics relevant to carbon monoxide activation. (1) Exploratory studies of water gas shift catalysts heterogenized on polystyrene based polymers. (2) Mechanistic investigation of the nucleophilic activation of CO in metal carbonyl clusters. (3) Application of fast reaction techniques to prepare and to investigate reactive organometallic intermediates relevant to the activation of hydrocarbons toward carbonylation and to the formation of carbon-carbon bonds via the migratory insertion of CO into metal alkyl bonds.
1992-06-04
Variations of endonasal anatomy: relevance for the endoscopic endonasal transsphenoidal approach
UK PubMed Central (United Kingdom)
BackgroundThe endoscopic endonasal transsphenoidal approach (EETA) to the pituitary is performed by ear, nose, and throat (ENT) surgeons in collaboration with neurosurgeons but also...Full Text Available
2010-06-01
The Allometry of Host-Pathogen Interactions
UK PubMed Central (United Kingdom)
BackgroundUnderstanding the mechanisms that control rates of disease progression in humans and other species is an important area of research relevant to epidemiology and to translating...Full Text Available
Reenergizing Public Health Through Precaution
UK PubMed Central (United Kingdom)
The precautionary principle has provoked a spirited debate among environmentalists worldwide, but it is equally relevant to public health and shares much with primary prevention. Its central components...Full Text Available
2001-09-01
UK PubMed Central (United Kingdom)
The recent melamine crisis in China has pointed out a serious deficiency...Full Text Available
2009-08-26
Keeping the Corps: The Continued Relevance of the Corps ...
... XVIII Airborne Corps forces grew from one brigade of the 82nd Airborne Division to a multi-national organization of five full divisions (Eastern Area ...
2004-05-26
Grains, components and mixtures in biomedical ontologies
UK PubMed Central (United Kingdom)
BackgroundIn biomedical ontologies, mereological relations have always been subject to special interest due to their high relevance in structural descriptions of anatomical entities,...Full Text Available
Flavanols and Anthocyanins in Cardiovascular Health: A Review of Current Evidence
UK PubMed Central (United Kingdom)
Nowadays it is accepted that natural flavonoids present in fruits and plant-derived-foods are relevant, not only for technological reasons and organoleptic properties, but also because of their potential...Full Text Available
CTC Sentinel. Volume 3, Number 10, October 2010
... earns money through receiving protection funds from embattled ... relationship between the TTP and LI ... relevant considering that Pakistan's military is ...
2010-10-01
Agricultural production systems and environmental health.
UK PubMed Central (United Kingdom)
By the turn of the century, American farmers and ranchers will be producing food and fiber through the application of highly sophisticated systems that involve a broad spectrum of relevant factors--from...Full Text Available
1990-06-01
A Research Needs Assessment for waste plastics recycling: Volume 2, Project report. Final report
Energy Technology Data Exchange (ETDEWEB)
This second volume contains detailed information on a number of specific topics relevant to the recovery/recycling of plastics.
1994-12-01
Asymptotic functions and multiplication of distributions
International Nuclear Information System (INIS)
Considered is a new type of generalized asymptotic functions, which are not functionals on some space of test functions as the Schwartz distributions. The definition of the generalized asymptotic functions is given. It is pointed out that in future the particular asymptotic functions will be used for solving some topics of quantum mechanics and quantum theory.
1976-01-26
Energy Technology Data Exchange (ETDEWEB)
The Institute of Energetic and Nuclear Research - IPEN is a research and development institution, located in a densely populated area, in the city of Sao Paulo. The nuclear fuel cycle was developed from the Yellow Cake to the enrichment and reconversion at IPEN. After this phase, all the technology was transferred to private enterprises and to the Brazilian Navy (CTM/SP). Some plants of the fuel cycle were at semi-industrial level, with a production over 20 kg/h. As a research institute, IPEN accomplished its function of the fuel cycle, developing and transferring technology. With the necessity of space for the implementation of new projects, the uranium hexafluoride (UF{sub 6}) production plant was chosen, since it had been idle for many years and presented potential leaking risks, which could cause environmental aggression and serious accidents. This plant decommission required accurate planning, as this work had not been carried out in Brazil before, for this ...
2008-07-01
UMTRA project disposal cell cover biointrusion sensitivity assessment, Revision 1
International Nuclear Information System (INIS)
This study provides an analysis of potential changes that may take place in a Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cell cover system as a result of plant biointrusion. Potential changes are evaluated by performing a sensitivity analysis of the relative impact of root penetrations on radon flux out of the cell cover and/or water infiltration into the cell cover. Data used in this analysis consist of existing information on vegetation growth on selected cell cover systems and information available from published studies and/or other available project research. Consistent with the scope of this paper, no new site-specific data were collected from UMTRA Project sites. Further, this paper does not focus on the issue of plant transport of radon gas or other contaminants out of the disposal cell cover though it is acknowledged that such transport has the potential to be a significant pathway for contaminants to reach the environment during portions of the design life ...
2004-06-22
UMTRA project disposal cell cover biointrusion sensitivity assessment, Revision 1
Energy Technology Data Exchange (ETDEWEB)
This study provides an analysis of potential changes that may take place in a Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cell cover system as a result of plant biointrusion. Potential changes are evaluated by performing a sensitivity analysis of the relative impact of root penetrations on radon flux out of the cell cover and/or water infiltration into the cell cover. Data used in this analysis consist of existing information on vegetation growth on selected cell cover systems and information available from published studies and/or other available project research. Consistent with the scope of this paper, no new site-specific data were collected from UMTRA Project sites. Further, this paper does not focus on the issue of plant transport of radon gas or other contaminants out of the disposal cell cover though it is acknowledged that such transport has the potential to be a significant pathway for contaminants to reach the environment during portions of the design life ...
1995-10-01
Energy Technology Data Exchange (ETDEWEB)
In this work, ZnO thin films have been grown on glass substrates by using a solution of propanol (C{sub 3}H{sub 8}O), water (H{sub 2}O) and zinc acetate (Z{sub n}(CH{sub 3}CO{sub 2}){sub 2}) in acidified medium (pH 5). The obtained films were n doped with ytterbium (Yb) at the rates of 100, 200 and 300 ppm. The structural features of the doped films were investigated using XRD, atomic force microscopy and scanning electronic microscopy techniques. XRD analysis shows a strong (0 0 2) X-ray diffraction line for increasing Yb-doping amounts. This c-axis preferential orientation of ZnO crystallites is naturally required to use this oxide as transparent conductor in optoelectronic applications. Atomic force microscopy (AFM) analysis shows an enhancement in the surface roughness of the doped ZnO:Yb thin films. Optical measurements were performed in 300-1800 nm domain via transmittance T(lambda) and reflectance R(lambda) spectra. Conjoint optical and thermal properties were deduced from the ...
2009-10-19
International Nuclear Information System (INIS)
In this work, ZnO thin films have been grown on glass substrates by using a solution of propanol (C3H8O), water (H2O) and zinc acetate (Zn(CH3CO2)2) in acidified medium (pH 5). The obtained films were n doped with ytterbium (Yb) at the rates of 100, 200 and 300 ppm. The structural features of the doped films were investigated using XRD, atomic force microscopy and scanning electronic microscopy techniques. XRD analysis shows a strong (0 0 2) X-ray diffraction line for increasing Yb-doping amounts. This c-axis preferential orientation of ZnO crystallites is naturally required to use this oxide as transparent conductor in optoelectronic applications. Atomic force microscopy (AFM) analysis shows an enhancement in the surface roughness of the doped ZnO:Yb thin films. Optical measurements were performed in 300-1800 nm domain via transmittance T(?) and reflectance R(?) spectra. Conjoint optical and thermal properties were deduced from the optical measurements in reference to the ...
2009-10-19
Energy Technology Data Exchange (ETDEWEB)
The interdependence of thermodynamic parameters, phase equilibria, and electrochemical measurements can be used as a powerful tool in the development of high specific energy cells. These principles were used in the analysis of electrochemical experiments performed on ternary lithium-transition metal-oxide (M = Mn, Fe, and Co) positive electrodes. The free energies of formation of LiMnO/sub 2/, Li/sub 5/FeO/sub 4/, LiFeO/sub 2/, and LiCoO/sub 2/ were found to be -178.21, -399.88, -154.18, and 131.62 kcal/mol at 400/sup 0/C. The electrochemical displacement reactions were found to be reversible in LiCl/KCl molten salt cells over a range of 0.0-3.0 Li equivalents per mol at current densities of 5-15 mA/cm/sup 2/. The equilibrium potential vs. Li was found to be a logarithmic function of the calculated oxygen partial pressure for any tie triangle in which Li/sub 2/O is present, or for any tie triangle containing ternary oxide phases Li /SUB x/ MO /SUB y/ which are only ...
1984-03-01
Point-contact Andreev-reflection spectroscopy in MgB{sub 2}: The role of substitutions
Energy Technology Data Exchange (ETDEWEB)
We summarize the results of point-contact Andreev-reflection (PCAR) spectroscopy in MgB{sub 2} doped by chemical substitutions, either magnetic (Mn) or non-magnetic (Al,C), obtained by us and by other groups in the last four years. Despite the variety of samples used (crystals and polycrystals of various origin) and some minor differences in the experimental techniques, these measurements have directly provided a complete and consistent picture of the effects of chemical substitutions on the gaps of MgB{sub 2} shedding light on other relevant parameters (scattering rates, DOSs) affected by doping. In Al-doped crystals and polycrystals, the gap amplitudes {delta}{sub {sigma}} and {delta}{sub {pi}} - obtained through a two-band Blonder-Tinkham-Klapwijk (BTK) fit of the Andreev-reflection conductance curves - decrease on increasing the Al content x (i.e. on decreasing the critical temperature of the contacts T{sub c}{sup A}), but remain clearly distinct with no ...
2007-06-01
Maximum imaging depth of two-photon autofluorescence microscopy in epithelial tissues
Endogenous fluorescence provides morphological, spectral, and lifetime contrast that can indicate disease states in tissues. Previous studies have demonstrated that two-photon autofluorescence microscopy (2PAM) can be used for noninvasive, three-dimensional imaging of epithelial tissues down to approximately 150 ?m beneath the skin surface. We report ex-vivo 2PAM images of epithelial tissue from a human tongue biopsy down to 370 ?m below the surface. At greater than 320 ?m deep, the fluorescence generated outside the focal volume degrades the image contrast to below one. We demonstrate that these imaging depths can be reached with 160 mW of laser power (2-nJ per pulse) from a conventional 80-MHz repetition rate ultrafast laser oscillator. To better understand the maximum imaging depths that we can achieve in epithelial tissues, we studied image contrast as a function of depth in tissue phantoms with a range of relevant optical properties. The ...
2011-02-01
It is hypothesized that systemic ??-noradrenergic antagonists may interfere with the transmission of sensory stimulation, particularly vaginal--cervical stimulation (VCS), which is crucial for reproductive functioning. To determine if ??-noradrenergic transmission receptor activity is necessary for transmission of sensory information important for VCS-dependent events, we conducted an experiment using prazosin, a ??-noradrenergic receptor antagonist. First, three doses of prazosin (1.0, 0.5 or 0.1 mg/kg) or the 10% ETOH in sesame oil vehicle were administered i.p. and sexual receptivity was assessed 30 min later in ovariectomized, hormone-treated female rats. The 1 mg/kg dose of prazosin significantly inhibited lordosis quotients and lordosis ratings. This dose of prazosin (1.0 mg/kg) was then administered 30 min prior to VCS or control scapular stimulation (CSS) and Fos-IR was examined in the posterodorsal medial amygdala (MeaPD), the medial preoptic area (mPOA), ...
2010-10-01
Distributed Data Integration Infrastructure
Energy Technology Data Exchange (ETDEWEB)
The Internet is becoming the preferred method for disseminating scientific data from a variety of disciplines. This can result in information overload on the part of the scientists, who are unable to query all of the relevant sources, even if they knew where to find them, what they contained, how to interact with them, and how to interpret the results. A related issue is keeping up with current trends in information technology often taxes the end-user's expertise and time. Thus instead of benefiting from this information rich environment, scientists become experts on a small number of sources and technologies, use them almost exclusively, and develop a resistance to innovations that can enhance their productivity. Enabling information based scientific advances, in domains such as functional genomics, requires fully utilizing all available information and the latest technologies. In order to address this problem we are developing a ...
2003-02-24
Calibration free laser-induced breakdown spectroscopy of oxide materials
Energy Technology Data Exchange (ETDEWEB)
The quantitative determination of oxide concentration by laser-induced breakdown spectroscopy is relevant in various fields of applications (e.g.: analysis of ores, concrete, slag). Calibration free laser-induced breakdown spectroscopy and the multivariate calibration are among the methods employed for quantitative concentration analysis of complex materials. We measured the intensity of neutral and ionized atomic emission lines of oxide materials by laser-induced breakdown spectroscopy and we modified the calibration free laser-induced breakdown spectroscopy method to increase the accuracy. The concentration of oxides was obtained by using stoichiometric relations. Sample materials were prepared from oxide powder (Fe{sub 2}O{sub 3}, MgO, CaO) by mixing and pressing. The concentration was 9.8-33.3 wt.% Fe{sub 2}O{sub 3}, 7.6-33.3 wt.% MgO and 33.3-81.2 wt.% CaO for different samples. Nd:YAG laser (wavelength 1064 nm, pulse duration {approx} 6 ns) ablation was ...
2010-08-15
Assessment of the PIUS physics and thermal-hydraulic experimental data bases
Energy Technology Data Exchange (ETDEWEB)
The PIUS reactor utilizes simplified, inherent, passive, or other innovative means to accomplish safety functions. Accordingly, the PIUS reactor is subject to the requirements of 10CFR52.47(b)(2)(i)(A). This regulation requires that the applicant adequately demonstrate the performance of each safety feature, interdependent effects among the safety features, and a sufficient data base on the safety features of the design to assess the analytical tools used for safety analysis. Los Alamos has assessed the quality and completeness of the existing and planned data bases used by Asea Brown Boveri to validate its safety analysis codes and other relevant data bases. Only a limited data base of separate effect and integral tests exist at present. This data base is not adequate to fulfill the requirements of 10CFR52.47(b)(2)(i)(A). Asea Brown Boveri has stated that it plans to conduct more separate effect and integral test programs. If appropriately ...
1993-12-31
International Nuclear Information System (INIS)
Carbon monoxide can be produced in severe accidents from interaction of ex-vessel molten core with concrete. Depending on the particular core-melt scenario, the type of concrete and geometric factors affecting the interaction, the quantities of carbon monoxide produced can vary widely, up to several volume percent in the containment. Carbon monoxide is a combustible gas. The carbon monoxide thus produced is in addition to the hydrogen produced by metal-water reactions and by radiolysis, and represents a possibly significant contribution to the combustible gas inventory in the containment. Assessment of possible accident loads to containment thus requires knowledge of the combustion properties of both CO and H_2 in the containment atmosphere. Extensive studies have been carried out and are still continuing in the nuclear industry to assess the threat of hydrogen in a severe reactor accident. However the contribution of carbon monoxide to the combustion threat has received less ...
1994-10-19
Transient optical and electrical effects in polymeric semiconductors
Energy Technology Data Exchange (ETDEWEB)
Classical semiconductor physics has been continuously improving electronic components such as diodes, light-emitting diodes, solar cells and transistors based on highly purified inorganic crystals over the past decades. Organic semiconductors, notably polymeric, are a comparatively young field of research, the first light-emitting diode based on conjugated polymers having been demonstrated in 1990. Polymeric semiconductors are of tremendous interest for high-volume, low-cost manufacturing (''printed electronics''). Due to their rather simple device structure mostly comprising only one or two functional layers, polymeric diodes are much more difficult to optimize compared to small-molecular organic devices. Usually, functions such as charge injection and transport are handled by the same material which thus needs to be highly optimized. The present work contributes to expanding the knowledge on the physical ...
2009-05-28
Is uniform target dose possible in IMRT plans in the head and neck?
International Nuclear Information System (INIS)
Purpose: Various published reports involving intensity-modulated radiotherapy (IMRT) plans developed using automated optimization (inverse planning) have demonstrated highly conformal plans. These reported conformal IMRT plans involve significant target dose inhomogeneity, including both overdosage and underdosage within the target volume. In this study, we demonstrate the development of optimized beamlet IMRT plans that satisfy rigorous dose homogeneity requirements for all target volumes (e.g., #+-#5%), while also sparing the parotids and other normal structures. Methods and Materials: The treatment plans of 15 patients with oropharyngeal cancer who were previously treated with forward-planned multisegmental IMRT were planned again using an automated optimization system developed in-house. The optimization system allows for variable sized beamlets computed using a three-dimensional convolution/superposition dose calculation and flexible cost functions derived ...
2002-04-01
International Nuclear Information System (INIS)
The IAEA Code of Practice on Quality Assurance for Safety in Nuclear Power Plants and the corresponding Safety Guides are reviewed and compared with quality assurance (QA) practices in the IAEA Member States. The QA requirements stipulated by the Code place on the nuclear power plant owner the responsibility to establish an overall QA programme for the plant. In selecting the QA programme level for specific activities, the Code allows of a flexible approach but does not specify gradation in programme requirements. The Code is placing the burden of quality-achieving and quality-assuring functions on the task-performing organizations, namely the designers, manufacturers, constructors and plant operators. The plant owner provides for the management of the overall QA programme, surveillance of activities and verifications of the effectiveness of the constituent programmes of all project participants through programme audits and evaluations. The Code and the supporting ...
The steroidogenic factor 1 (SF-1, also known as NR5A1) is a transcription factor belonging to the nuclear receptor superfamily. Whereas most of the members of this family have been extensively characterized, the therapeutic potential and pharmacology of SF-1 still remains elusive. Described here is the identification and characterization of selective inhibitory chemical probes of SF-1 by a rational ultra-high-throughput screening (uHTS) strategy. A set of 64,908 compounds from the National Institute of Health's Molecular Libraries Small Molecule Repository was screened in a transactivation cell-based assay employing a chimeric SF-1 construct. Two analogous isoquinolinones, ethyl 2-[2-[2-(2,3-dihydro-1,4-benzodioxin-7-ylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate (SID7969543) and ethyl 2-[2-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate and (SID7970631), were identified as potent submicromolar inhibitors, yielding ...
2008-03-11
Development of Guidelines for PSA-based Event Analysis (PSAEA) in an International Project
International Nuclear Information System (INIS)
A probabilistic precursor study provides a complement to the 'root cause' analysis approach by focusing on how an event might have developed adversely, and implies the mapping of an operational event on a probabilistic risk model of the plant in order to obtain a quantitative assessment of the safety significance of the event. In order to benefit from state-of-the-art PSA features but also to assure repeatability of the analysis, a comprehensive set of PSAEA guidelines was developed. This PSAEA procedure was established in 1996-1998 by Enconet Consulting in the framework of an international project on behalf of - and involving - the nuclear regulatory bodies from 6 countries: AECB (Canada), AVN (Belgium), CSN (Spain), HSK (Switzerland), NII (United Kingdom) and SKI (Sweden). The PSAEA procedure defines preliminary requirements for the PSA model and code, and identifies input requirements such as information on plant status, event sequence chronology and causes. The ...
2003-03-20
UK PubMed Central (United Kingdom)
The application of kinetic probes that allow one to determine relative reactivities of biologically relevant substrates with oxidizing intermediates in the Fenton reagent (H2O2 plus Fe2+ in acidic aqueous...Full Text Available
1994-07-05
Testing of CFC Targets by Plasma Heat Fluxes Relevant to Elms and Mitigated Disruptions in ITER
International Nuclear Information System (INIS)
Carbon fibre composite (CFC) was irradiated by hot plasma streams at plasma gun facility MK-200UG. The CFC targets were tested by plasma loads relevant to Edge Localized Modes (ELM) and mitigated disruptions in ITER. Onset condition of CFC evaporation and properties of evaporated carbon were studied by use of infrared pyrometry and visible spectroscopy.
2006-01-01
Management and organizational design: an initial look at a new project
International Nuclear Information System (INIS)
This project is designed to establish one basis for empirically linking aspects of management and organizational design to the safe operation of nuclear power plants. Current work is focusing on (a) reviewing existing literature relevant to this linkage, and (b) isolating and incorporating numerous safety relevant indicators. Later stages of this project will involve hypothesis development, data collection and analysis.
1983-01-01
The MHC molecules of nonmammalian vertebrates.
DEFF Research Database (Denmark)
There is very little known about the long-term evolution of the MHC and MHC-like molecules. This is because both the theory (the evolutionary questions and models) and the practice (the animals systems, functional assays and reagents to identify and characterize these molecules) have been difficult to develop. There is no molecular evidence yet to decide whether vertebrate immune systems (and particularly the MHC molecules) are evolutionarily related to invertebrate allorecognition systems, and the functional evidence can be interpreted either way. Even among the vertebrates, there is great heterogeneity in the quality and quantity of the immune response. The functional evidence for T-lymphocyte function in jawless and cartilagenous fish is poor, while the bony fish seem to have many characteristics of a mammalian immune system. The organization and sequence of fish Ig genes also ...
1990-01-01
Viscoplasticity of elastomeric materials: experimental facts and constitutive modelling
Energy Technology Data Exchange (ETDEWEB)
A characteristic of filled elastomers is their ability to undergo very large deformations without damaging their internal structure. The material behaviour is mainly elastic, however, elastomers show hysteresis effects leading to damping properties, which are quite important as regards their applications in various fields of mechanical engineering.A series of experiments (tension, torsion and combinations of both) was carried out on cylindrical bars made of a carbon-black filled rubber mixture. In addition to a pronounced nonlinear rate-dependence, relaxation and viscosity properties are observed as being influenced by the process histories.The behaviour of elastomeric materials is modelled on the basis of a free energy function and evolution equations for additional internal variables. Incorporating or disregarding the very small rate-independent hysteresis, the constitutive modelling may be classified under viscoplasticity or viscoelasticity. The constitutive ...
2001-03-01
Energy Technology Data Exchange (ETDEWEB)
The low excitation energy spectroscopy of /sup 86/Sr, /sup 88/Sr, /sup 89/Sr, /sup 86/Rb, and /sup 87/Rb nuclear systems was studied via one-nucleon transfer reactions. The strontium isotopes, /sup 87/Sr and /sup 88/Sr, were used as targets in this study. Spectroscopic strengths were extracted from the measured transfer reaction cross sections and the distorted wave Born approximation (DWBA) analysis. Efforts have been made to accomplish a complete detection of spectroscopic strengths through the excitation energy region where levels can be resolved and identified. A shell model sum rule analysis is then made. Diagonal matrix elements for the effective two-nucleon interaction were deduced from empirical energy centroid. Matrix elements normalized by their empirical monopole energy was plotted against the semiclassical angle between two spins. They were compared with various analytical function forms of the effective two-nucleon interaction ...
1987-01-01
International Nuclear Information System (INIS)
The low excitation energy spectroscopy of "8"6Sr, "8"8Sr, "8"9Sr, "8"6Rb, and "8"7Rb nuclear systems was studied via one-nucleon transfer reactions. The strontium isotopes, "8"7Sr and "8"8Sr, were used as targets in this study. Spectroscopic strengths were extracted from the measured transfer reaction cross sections and the distorted wave Born approximation (DWBA) analysis. Efforts have been made to accomplish a complete detection of spectroscopic strengths through the excitation energy region where levels can be resolved and identified. A shell model sum rule analysis is then made. Diagonal matrix elements for the effective two-nucleon interaction were deduced from empirical energy centroid. Matrix elements normalized by their empirical monopole energy was plotted against the semiclassical angle between two spins. They were compared with various analytical function forms of the effective two-nucleon interaction depending on their spins, ...
Towards an accurate model of the redshift space clustering of halos in the quasilinear regime
Observations of redshift-space distortions in spectroscopic galaxy surveys offer an attractive method for measuring the build-up of cosmological structure, which depends both on the expansion rate of the Universe and our theory of gravity. Galaxies occupy dark matter halos, whose redshift space clustering has a complex dependence on bias that cannot be inferred from the behavior of matter. We identify two distinct corrections on quasilinear scales (~ 30-80 Mpc/h): the non-linear mapping between real and redshift space positions, and the non-linear suppression of power in the velocity divergence field. We model the first non-perturbatively using the scale-dependent Gaussian streaming model, which we show is accurate at the 10 (s>25) Mpc/h for the monopole (quadrupole) halo correlation functions. We use perturbation theory to predict the real space pairwise halo velocity statistics. Our fully analytic model is accurate at the 2 per cent level ...
2011-01-01
Energy Technology Data Exchange (ETDEWEB)
We report the results of ab initio calculations of cross sections and molecular-frame photoelectron angular distributions for C 1s ionization of CO2, and propose a mechanism for the recently observed asymmetry of those angular distributions with respect to the CO^+and O^+ions produced by subsequent Auger decay. The fixed-nuclei, photoionization amplitudes were constructed using variationally obtained electron-molecular ion scattering wave functions. We have also carried out electronic structure calculations which identify a dissociative state of the CO2^++ dication that is likely populated following Auger decay and which leads to O^+ + CO^+ fragment ions. We show that a proper accounting of vibrational motion in the computation of the photoelectron angular distributions, along with reasonable assumptions about the nuclear dissociation dynamics, gives results in good agreement with recent experimental observations. We also demonstrate that ...
2009-02-18
The influence of prior ageing on creep damage development in two variants of Alloy 800
Energy Technology Data Exchange (ETDEWEB)
The influence of high temperature thermal ageing treatments on the development of intercrystalline creep damage in two variants of Alloy 800 has been investigated. Ageing up to 3000 h and creep testing were carried out at 800 and 900 C. The high temperature behaviour of the 800HT variant is discussed with reference to the effect of heat treatments on the microstructure. The metallographic methods by which the creep damage was quantitatively determined are described. The growth rate of intercrystalline microcracks was described using a statistical model and the dependence of crack growth rate on the thermal history for both 800HT and 800H was determined. The carbide precipitation and growth processes were determined as functions of the exposure temperature and duration. The results showed the three characteristic stages, precipitation, growth and coarsening (Ostwald ripening). The largest increase in the intergranular creep damage was found in Alloy 800HT within the ...
1997-06-01
The experience of obsolete item identification and solution in CANDU NPPs
International Nuclear Information System (INIS)
Design and procurement of equipment for nuclear power plant took place in late 1970's. A large number of originally installed equipment is obsolete. The manufacturer's do not support their products or have discontinued their production due to technological evolutions or lack of product demand. Lack of spares affects the performance of obsolete equipment and has a negative impact on plant safety and plant production. A proactive approach to address obsolescence is necessary to ensure critical spares are always available when needed. This is an ongoing effort and requires a program to be in place to resolve immediate and longterm issues. A cross-functional team with adequate external exposure is needed to administer the obsolescence program. CANDU utilities and CANDU Owners Group(COG) has taken initiatives to identify lack of equipment spares in the members' plant. The equipment replacement information collected from each CANDU nuclear power ...
2010-10-01
The edge of neutral evolution in social dilemmas
Energy Technology Data Exchange (ETDEWEB)
The functioning of animal as well as human societies fundamentally relies on cooperation. Yet, defection is often favorable for the selfish individual, and social dilemmas arise. Selection by individuals' fitness, usually the basic driving force of evolution, quickly eliminates cooperators. However, evolution is also governed by fluctuations that can be of greater importance than fitness differences, and can render evolution effectively neutral. Here, we investigate the effects of selection versus fluctuations in social dilemmas. By studying the mean extinction times of cooperators and defectors, a variable sensitive to fluctuations, we are able to identify and quantify an emerging 'edge of neutral evolution' that delineates regimes of neutral and Darwinian evolution. Our results reveal that cooperation is significantly maintained in the neutral regimes. In contrast, the classical predictions of evolutionary game ...
2009-09-15
The dependence of radiation hardening and embrittlement on irradiation temperature
International Nuclear Information System (INIS)
Assessments of the hardening and embrittlement of pressure vessel steels and welds as a function of neutron dose use trend curves derived from surveillance programs and accelerated irradiation data. A temperature dependent factor is incorporated for assessing vessel locations operating at different temperatures. As hardening and embrittlement arise from the sum of matrix damage and copper impurity precipitation, the influence of irradiation temperature on each process needs to be established. For irradiations performed below #approx# 300 C recent data shows that the dose-dependent growth of copper precipitates ceases at a mean diameter of about 2 nm that also corresponds to peak hardening and embrittlement by copper. For doses beyond this peak copper dose the property-dependence on irradiation temperature can be identified with that of matrix damage alone. An analysis of several experiments on plate steels, performed at differing irradiation ...
1994-06-20
TRANS-NEPTUNIAN OBJECTS WITH HUBBLE SPACE TELESCOPE ACS/WFC
International Nuclear Information System (INIS)
We introduce a novel search technique that can identify trans-Neptunian objects in three to five exposures of a pointing within a single Hubble Space Telescope (HST) orbit. The process is fast enough to allow the discovery of candidates soon after the data are available. This allows sufficient time to schedule follow-up observations with HST within a month. We report the discovery of 14 slow-moving objects found within 50 of the ecliptic in archival data taken with the Wide Field Channel of the Advanced Camera for Surveys. The luminosity function of these objects is consistent with previous ground-based and space-based results. We show evidence that the size distribution of both high and low inclination populations is similar for objects smaller than 100 km, as expected from collisional evolution models, while their size distribution differs for brighter objects. We suggest that the two populations formed in different parts of the ...
2010-10-20
Student Concern and Potential Action Regarding Nuclear Threat.
Throughout their history, Americans have believed that citizens' fulfillment of their individual duties in a participatory democracy is at least partly met through the forming of groups around important societal issues. Given the complex nature of political socialization, this study investigated identifiable determinants of social action that might be used to advantage in educating young people for citizenship in a democracy. This study attempted to differentiate among junior high, high school and college students (N=517) who were inclined and not inclined to act on their concerns about nuclear threat with selected demographic, psychological, political, and educational variables. The results of a discriminant functional analysis indicated that in comparison with the non-action group, students in the action group were characterized by reporting less trust in government, more exposure to sources of nuclear war information, more political ...
1990-08-01
Source term attenuation by water in the Mark I boiling water reactor drywell
Energy Technology Data Exchange (ETDEWEB)
Mechanistic models of aerosol decontamination by an overlying water pool during core debris/concrete interactions and spray removal of aerosols from a Mark I drywell atmosphere are developed. Eighteen uncertain features of the pool decontamination model and 19 uncertain features of the model for the rate coefficient of spray removal of aerosols are identified. Ranges for values of parameters that characterize these uncertain features of the models are established. Probability density functions for values within these ranges are assigned according to a set of rules. A Monte Carlo uncertainty analysis of the decontamination factor produced by water pools 30 and 50 cm deep and subcooled 0--70 K is performed. An uncertainty analysis for the rate constant of spray removal of aerosols is done for water fluxes of 0.25, 0.01, and 0.001 cm{sup 3} H{sub 2}O/cm{sup 2}-s and decontamination factors of 1.1, 2, 3.3, 10, 100, and 1000.
1993-09-01
Roles for Rat Hepatocyte Malignant Transforming Factor (HMTF) in Late Stage of Hepatocarcinogenesis.
In a previous study, to identify genes of importance for hepatocellular carcinogenesis, and especially for processes involved in malignant transformation, the authors investigated differences in gene expression between adenomas and carcinomas by DNA microarray. In the present study, the authors investigated AW434047, one of the sequences that was upregulated in carcinomas. The investigation led to the identification of a novel gene, which the authors named hepatocyte malignant transforming factor (HMTF), of unknown function whose expression was increased in hepatocellular carcinomas. Northern blot and in situ hybridization also demonstrated high levels of HMTF in rat hepatocellular carcinoma (HCC) cell lines, lymphocytes in the spleen, colon mucosal epithelia, spermatocytes, and granule cells of the hippocampus. Reduction of HMTF by RNA interference (RNAi) in N1 cells, an HCC cell line, caused suppression of cell proliferation, invasion, and ...
2011-09-20
Energy Technology Data Exchange (ETDEWEB)
The paper gives results of a study to identify active sites and surface functional groups that may contribute to the absorption of elemental mercury (Hg) by relatively inexpensive calcium (Ca)-based sorbents. The study investigated the formation of chlorine (Cl) sites in CA-based sorbents as well as their role and reactivity in the absorption of Hg. HCl-exposed calcium sulfate dihydrate (gypsum) exhibited a superior Hg sorption capability. Crystalline water molecules on the surface of the gypsum were confirmed to contribute indirectly to Hg uptake. These surface molecules may have absorbed HC1 through hydrogen bond formation between an oxygen atom of a crystalline water molecule and a hydrogen atom of an HCl molecule. Two adjacent, physically absorbed HCl molecules could then trap an Hg molecule through formation of a mercuric-chloride-like molecule. Significant correlations between Cl and Hg uptake by gypsum were noted.
1999-11-01
Energy Technology Data Exchange (ETDEWEB)
The paper gives results of a study to identify active sites and surface functional groups that may contribute to the absorption of elemental mercury (Hg) by relatively inexpensive calcium (Ca)-based sorbents. The study investigated the formation of chlorine (Cl) sites in CA-based sorbents as well as their role and reactivity in the absorption of Hg. HCl-exposed calcium sulfate dihydrate (gypsum) exhibited a superior Hg sorption capability. Crystalline water molecules on the surface of the gypsum were confirmed to contribute indirectly to Hg uptake. These surface molecules may have absorbed HC1 through hydrogen bond formation between an oxygen atom of a crystalline water molecule and a hydrogen atom of an HCl molecule. Two adjacent, physically absorbed HCl molecules could then trap an Hg molecule through formation of a mercuric-chloride-like molecule. Significant correlations between Cl and Hg uptake by gypsum were noted.
1999-01-01
Polypropylene surface modification by active screen plasma nitriding
International Nuclear Information System (INIS)
Here we describe the use of low energy plasma immersion with active screen as a convenient approach for polypropylene (PP) surface modification. Employing a stainless steel cathodic cage coated with carbon in order to prevent the sputtering of iron from the grid and its deposition onto the polymer sample, the physical chemical properties of PP surface could be effectively modified through the plasma-induced incorporation/formation of nitrogen- and oxygen-containing species. The areal densities of these elements depended on the plasma excitation source, as determined by Rutherford backscattering spectrometry (RBS). Newly formed C-O, C-N, and C=O/O=C-O/N-C=O bonds along with C-C linkages from the PP backbone were identified at the near surface region of the specimens by X-ray photoelectron spectroscopy (XPS). The insertion of such polar reactive functionalities was further confirmed by a substantial decrease in the water contact angle upon plasma ...
2009-03-01
Particle-hole strength excited in the /sup 40/Ca(p,n)/sup 40/Sc reaction at 134 MeV
International Nuclear Information System (INIS)
The /sup 40/Ca(p,n)/sup 40/Sc reaction was studied at 134 MeV. Neutron energy spectra were measured by the time-of-flight technique with resolutions of 220 keV at angles from 0"0 to 41"0 and 415 keV out to 62"0. The 2"-,3"-,4"-,5"- band of states based on the (f/sub 7/2/,d/sub 3/2//sup -1/) 1p1h structure was observed at low excitation energies, in good agreement with known analog states in /sup 40/Ca and /sup 40/K. The shapes of the cross-section and analyzing-power angular distributions are in good agreement with distorted-wave impulse-approximation calculations using simple 1p1h (Tamm-Dancoff approximation) shell-model wave functions. A relatively strong transition to a state at E/sub x/ = 2.3 MeV with L = 3 is identified tentatively as a 4"- state with the predominant 1p1h structure (1f/sub 7/2/,2s/sub 1/2//sup -1/).
One-class classifiers and their application to synthetic aperture radar target recognition
Energy Technology Data Exchange (ETDEWEB)
Target recognition requires the ability to distinguish targets from non-targets, a capability called one-class generalization. To function as a one-class classifier, a neural network must have three types of generalization: within-class, between-class, and out-of-class. We discuss these three types of generalization and identify neural network architectures that meet these requirements. We have applied our one-class classifier ideas to the problem of automatic target recognition in synthetic aperture radar. We have compared three neural network algorithms: Carpenter and Grossberg`s algorithmic version of the Adaptive Resonance Theory (ART-2A), Kohonen`s Learning Vector Quantization (LVQ), and Reilly and Cooper`s Restricted Columb Energy network (RCE). The ART 2-A neural network has given the best results, with 100% within-class, and out-of-class generalization. Experiments show that the network`s performance is sensitive to vigilance and number ...
1992-10-01
One-class classifier networks for target recognition applications
Energy Technology Data Exchange (ETDEWEB)
Target recognition requires the ability to distinguish targets from non-targets, a capability called one-class generalization. Many neural network pattern classifiers fail as one-class classifiers because they use open decision boundaries. To function as one-class classifier, a neural network must have three types of generalization: within-class, between-class, and out-of-class. We discuss these three types of generalization and identify neural network architectures that meet these requirements. We have applied our one-class classifier ideas to the problem of automatic target recognition in synthetic aperture radar. We have compared three neural network algorithms: Carpenter and Grossberg`s algorithmic version of the Adaptive Resonance Theory (ART-2A), Kohonen`s Learning Vector Quantization (LVQ), and Reilly and Cooper`s Restricted Coulomb Energy network (RCE). The ART 2-A neural network gives the best results, with 100% within-class, ...
1993-01-01
British Library Electronic Table of Contents (United Kingdom)
Cytoplasmic male sterility (CMS) is a maternally inherited trait that fails to produce functional pollen grains. The CMS system is widely employed to facilitate the utilization of heterosis in major crops. However, little is known about the CMS associated genes in Upland cotton (Gossypium hirsutum). The objective of this study was to compare CMS cotton (CMS-D2) with the cytoplasm from G. harknessii and its isogenic maintainer line with the normal fertile Upland cotton cytoplasm to identify CMS-D2 specific gene(s) and to develop CMS-specific sequence characterized amplified region (SCAR) markers. Based on Southern blot analysis using 10 mitochondrial gene-specific probes (cob, cox2, atp6, atp9, nad3, cox3, atpA, cox1, nad6 and nad9), three probes (cox3, atpA, and nad6) revealed restriction ...
2011-01-01
Energy Technology Data Exchange (ETDEWEB)
[alpha]-Melanocyte stimulating hormone ([alpha]-MSH), a hormone originally named for its ability to regulate pigmentation of melanocytes, is a 13-amino-acid post-translational product of the pro-opiomelanocortin (POMC) gene. [alpha]-MSH and the other products of POMC processing, which share the core heptapeptide amino acid sequence Met-Glu (Gly)-His-Phe-Arg-Trp-Gly (Asp), the adrenocorticotropic hormone (ACTH), [beta]-MSH, and [gamma]-MSH, are collectively referred to as melanocortins. While best known for their effects on the melanocyte (pigmentation) and adrenal cortical cells (steroidogenesis), melanocortins have been postulated to function in diverse activities, including enhancement of learning and memory, control of the cardiovascular system, analgesia, thermoregulation, immunomodulation, parturition, and neurotrophism. To identify the chromosomal band encoding the human melanocortin-1 receptor gene, 1 [mu]g of an EMBL clone coding region ...
1994-01-15
Machine fault signature analysis by midpoint-based empirical mode decomposition
The fault signature can be revealed by vibration analysis in machine fault detection and diagnosis. Empirical mode decomposition (EMD) is a self-adaptive method that can decompose a vibration signal into informative intrinsic mode functions (IMFs). This paper addresses the improvement of the weakness of the traditional EMD algorithm and presents a new midpoint-based EMD method for effective fault signature analysis of a rotating machine. In the proposed method, geometrical midpoints of successive extrema are employed to estimate the local mean of an analyzed signal. Signal decomposition is then self-adaptively performed to achieve IMFs through removal of the midpoint-based local means. The representative IMF containing fault information is selected for identifying the fault signature. The effectiveness of the proposed method was verified by means of simulation and an application to gear fault diagnosis. Results indicated that the midpoint-based ...
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of recessive PD. Autophagy, a pathway for clearance of protein aggregates or impaired organelles, is a newly identified mechanism for PD development. However, it is still unclear what molecules regulate autophagy in PINK1-silenced cells. Here we report that autophagosome formation is promoted in the early phase in response to PINK1 gene silencing by lentivirus transfer vectors expressed in mouse striatum. Reduced PP2A activity and increased phosphorylation of PP2A at Y307 (inactive form of PP2A) were observed in PINK1-knockdown dopaminergic cells and striatum tissues. Treatment with C2-ceramide (an agonist of PP2A) reduced autophagy levels in PINK...
2011-01-01
Local therapies to heal the penis: fact or fiction?
Penile rehabilitation has been an area of intense study and debate over the last decade. Interest in this topic was stimulated by the observation that erectile dysfunction remained a significant problem after radical prostatectomy despite meticulous nerve-sparing technique. Smooth muscle alterations and fibrotic changes in the penis were identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and Peyronie's-like changes that were observed after surgery. Initial observations that intracavernous injection therapies used on a regular basis postoperatively resulted in improvements in the return of spontaneous erectile function led to the development of penile rehabilitation protocols. Chronic dosing of oral type V phosphodiesterase inhibitors is now commonly used by urologists after radical prostatectomy despite a lack of convincing evidence from randomized, placebo-controlled clinical trials. Use of local therapies to ...
2008-11-20
Kinetic study of steam gasification of coke: II-Study in fluidized bed reactor
Energy Technology Data Exchange (ETDEWEB)
This work reports an experimental study on the steam gasification of an anthracite coke in a fluidized bed reactor, with the aim of evaluating the reaction kinetics. Isothermal runs were carried out with samples of 91 to 275 g of coke, at temperatures between 799 and 928{sup 0}C and for steam partial pressures between 0.3 and 0.9 atm. The conversion decreases as the amount of coke is increased and it is very sensitive to the temperature. Neither the volumetric reaction model nor the unreacted shrinking core model can satisfactorily fit the experimental results. That is why empirical models have been used. The first one is derived from the unreacted shrinking core model. An activation energy of 219 kJ. mol{sup -1} and a reaction order with respect of steam of 0.57 have been identified. In the second model, the conversion has been correlated as a function of a dimensionless time. A comparison of the results obtained in the fluidized bed with ...
1989-01-01
Investigation of the impact of electricity rate and mix on optimum green building design
Energy Technology Data Exchange (ETDEWEB)
The basic principle of the green building philosophy is to design buildings that consider environmental performance. Residential and commercial buildings in Canada consume about 30 per cent of the total secondary energy use and are responsible for approximately 29 per cent of carbon dioxide equivalent greenhouse gas emissions and many other wastes. An optimization model was developed which minimizes life cycle cost and life cycle environmental impact. The model distinguishes different energy sources and incorporates their impacts, such as resource depletion, global warming and acidification. The model also considers design variables such as window type, orientation, building orientation, window-to-wall ratio, wall type and roof type. The model can be used to identify optimum green building designs for given conditions. The model uses expanded cumulative exergy consumption as the indicator for life cycle environmental performance. As such, it can be simplified by ...
2004-07-01
Energy Technology Data Exchange (ETDEWEB)
We have created quasiprojectiles of varying isospin via peripheral reactions of {sup 28}Si+{sup 112}Sn and {sup 124}Sn at 30 and 50 MeV/nucleon. The quasiprojectiles have been reconstructed from completely isotopically identified fragments. The difference in N/Z of the reconstructed quasiprojectiles allows the investigation of the disassembly as a function of the isospin of the fragmenting system. The isobaric yield ratio {sup 3}H/{sup 3}He depends strongly on N/Z ratio of quasiprojectiles. The dependences of mean fragment multiplicity and mean N/Z ratio of the fragments on N/Z ratio of the quasiprojectile are different for light charged particles and intermediate mass fragments. Observation of a different N/Z ratio of light charged particles and intermediate mass fragments is consistent with an inhomogeneous distribution of isospin in the fragmenting system.
2000-10-01
International Nuclear Information System (INIS)
Aiming at the non-stationary characteristics of differential pressure fluctuation signals of gas-liquid two-phase flow, and the slow convergence of learning and liability of dropping into local minima for BP neural networks, flow regime identification method based on Singular Value Decomposition (SVD) and Least Square Support Vector Machine (LS-SVM) is presented. First of all, the Empirical Mode Decomposition (EMD) method is used to decompose the differential pressure fluctuation signals of gas-liquid two-phase flow into a number of stationary Intrinsic Mode Functions (IMFs) components from which the initial feature vector matrix is formed. By applying the singular vale decomposition technique to the initial feature vector matrixes, the singular values are obtained. Finally, the singular values serve as the flow regime characteristic vector to be LS-SVM classifier and flow regimes are identified by the output of the classifier. The ...
2007-12-01
International Nuclear Information System (INIS)
A radioimmunoassay is described for the molluscan neuropeptide, Phe-Met-Arg-Phe-NH"2(FMRFamide). The antibody used is C-terminal-specific and shows slight but significant (1-2%) cross-reactivity with chicken pancreatic polypeptide (APP). The assay has been used to identify in rat brain extracts a pair of molecules that may represent mammalian counterparts of FMRFamide. Their concentrations were highest in spinal cord and hypothalamus (>10 pmol.g"-_1) and lowest in cerebellum and striatum (<3.5 pmol.g"-_1). The two immunoreactive peptides were separated on CM ion-exchange chromatography where they appeared to be less basic than FMRFamide. On Sephadex G50 gel filtration one eluted in a similar position to FMRFamide and the other slightly earlier suggesting it may be of higher molecular weight. The rat immunoreactive components do not correspond to previously described neuropeptides or hormones, and may be members of a new group of mammalian neuropeptides with ...
FFTF fission gas monitor computer system
International Nuclear Information System (INIS)
The Fast Flux Test Facility (FFTF) is a liquid-metal-cooled test reactor located on the Hanford site. A dual computer system has been developed to monitor the reactor cover gas to detect and characterize any fuel or test pin fission gas releases. The system acquires gamma spectra data, identifies isotopes, calculates specific isotope and overall cover gas activity, presents control room alarms and displays, and records and prints data and analysis reports. The fission gas monitor system makes extensive use of commercially available hardware and software, providing a reliable and easily maintained system. The design provides extensive automation of previous manual operations, reducing the need for operator training and minimizing the potential for operator error. The dual nature of the system allows one monitor to be taken out of service for periodic tests or maintenance without interrupting the overall system functions. A built-in calibrated ...
Energy Technology Data Exchange (ETDEWEB)
A model-base expert system is presented for the processing of alarm messages in power networks' control centers. This alarm processor, called GESTAL, generates concise diagnoses identifying the causes(s) of network disturbances and describing the operation of the protection and alarm systems which operate to isolate faulty components. Essentially, the alarm processor is an agenda driven expert system which is composed of a model of the power network's alarm and protection systems as well as several sets of rules. Based on the nextwork model, graph structures are constructed which represent relationships between alarms as they are received. These graph structures are then analysed in order to diagnose the disturbances(s). The alarm processor has been developed using the ART 3.0 programming language in a Symbolics Lisp-machine environment. Background material on expert systems, electric power networks, and alarm processing software is included, as ...
1987-01-01
We present an x-ray magnetic circular dichroism (XMCD) study performed on both Ho{sub 6}Fe{sub 23} and Y{sub 6}Fe{sub 23} compounds as a function of the temperature. The combined analysis of both Fe K-edge and Ho L{sub 2,3}-edge XMCD spectra recorded through the magnetic compensation transition allows us to disentangle the thermal dependence of both Fe and Ho magnetic moments in Ho{sub 6}Fe{sub 23}. In addition, contributions from Ho ions to the Fe K-edge XMCD signals and, conversely, from Fe ions to the Ho L{sub 2,3}-edge XMCD spectra have been clearly identified. These extra contributions, arising from the strong Fe(3d)-Ho(5d) hybridization, have been isolated from the spectra and correlated with the magnetic state of both Ho and Fe ions surrounding the absorbing site. The influence of these contributions to the values of the orbital and spin moments derived by using sum rule analysis is also shown.
2005-09-01
The Drosophila melanogaster tissue-specific transcription factor NTF-1 was originally identified in vitro as a protein that could bind to and activate transcription from the Dopa decarboxylase (Ddc) gene. A structure-function analysis of NTF-1 led to the identification of a discrete amino-terminal activation domain. Here, we report that an NTF-1 mutant lacking the activation domain acts as a trans-dominant inhibitor of NTF-1 activation in tissue culture cells by forming inactive heterodimers with the full-length protein. Ectopically expressing this dominant-negative protein or the full-length protein in developing Drosophila embryos leads to dire developmental consequences. Overexpressing the trans-dominant NTF-1 leads to lethality, while overexpressing full-length NTF-1 results in both lethality and morphogenetic defects. Our results suggest that both the activity and the regulation of NTF-1 are critical for viability and proper development of ...
1993-11-15
ELMO Bumpy Torus Reactor and power plant: conceptual design study
International Nuclear Information System (INIS)
A complete power plant design of a 1200-MWe ELMO Bumpy Torus Reactor (EBTR) is presented. An emphasis is placed on those features that are unique to the EBT confinement concept, with subsystems and balance-of-plant items that are more generic to magnetic fusion being adapted from past, more extensive tokamak reactor designs. Similar to the latter tokamak studies, this conceptual EBTR design also emphasizes the use of conventional or near state-of-the-art engineering technology and materials. An emphasis is also placed on system accessibility, reliability, and maintainability, as these crucial and desirable characteristics relate to the unique high-aspect-ratio configuration of EBTs. Equal and strong emphasis is given to physics, engineering/technology, and costing/economics components of this design effort. Parametric optimizations and sensitivity studies, using cost-of-electricity as an object function, are reported. Based on these results, the direction for ...
1988-10-09
Dynamic Batch Bayesian Optimization
Bayesian optimization (BO) algorithms try to optimize an unknown function that is expensive to evaluate using minimum number of evaluations/experiments. Most of the proposed algorithms in BO are sequential, where only one experiment is selected at each iteration. This method can be time inefficient when each experiment takes a long time and more than one experiment can be ran concurrently. On the other hand, requesting a fix-sized batch of experiments at each iteration causes performance inefficiency in BO compared to the sequential policies. In this paper, we present an algorithm that asks a batch of experiments at each time step t where the batch size p_t is dynamically determined in each step. Our algorithm is based on the observation that the sequence of experiments selected by the sequential policy can sometimes be almost independent from each other. Our algorithm identifies such scenarios and request those experiments at the same time ...
2011-01-01
Development of functional foods for radiation workers
Energy Technology Data Exchange (ETDEWEB)
In searching modulators of immunity and hematopoiesis among natural products, being used as foods, six herbs exhibited lymphocyte proliferation in vitro, and six exhibited augmentation of hematopoietic cell growth. The combined treatments showed synergistic effects of lymphocyte proliferation and of hematopoietic cell growth. On the other hand, we found four effective oriental medicinal prescriptions, used as energy tonic or blood-building decoctions, for survival and regeneration of hematopoietic cells and for protection of stem cells of intestinal crypt in irradiated mice. On the basis of these results, extracts from combinations of herbs were made in expectation of higher effects in the three respects. In immuno modulation activity by the two combinations of herbs was confirmed in mice. In culture of bone narrow cells, growth improvement of non-adherent precursor and induction of cytokine expression by herb mixture extracts were observed. In evaluation of fractions, polysaccharide ...
2000-03-01
Degradation mechanisms and accelerated aging test design
Energy Technology Data Exchange (ETDEWEB)
The fundamental mechanisms underlying the chemical degradation of polymers can change as a function of environmental stress level. When this occurs, it greatly complicates any attempt to use accelerated tests for predicting long-term material degradation behaviors. Understanding how degradation mechanisms can change at different stress levels facilitates both the design and the interpretation of aging tests. Oxidative degradation is a predominant mechanism for many polymers exposed to a variety of different environments in the presence of air, and there are two mechanistic considerations which are widely applicable to material oxidation. One involves a physical process, oxygen diffusion, as a rate-limiting step. This mechanism can predominate at high stress levels. The second is a chemical process, the time-dependent decomposition of peroxide species. This leads to chain branching and can become a rate-controlling factor at lower stress levels involving time-scales ...
1985-01-01
Crystal field and EPR studies of Nd{sup 3+}:YMO{sub 4}(M=V,AS,P)
Energy Technology Data Exchange (ETDEWEB)
Crystal field calculation and electron paramagnetic resonance (EPR) have been performed on zircon-type materials Nd:YMO{sub 4} (M=V, As, P). Simulation of the energy level schemes has been carried out and the wave functions composition and g tensor principal values associated to the first sub-level of the {sup 4}I{sub 9/2} manifold were calculated. A rather good correlation is obtained between crystal field calculations and the EPR measurements. Furthermore, some extra lines observed by optical spectroscopy (absorption and emission) also appear on the EPR spectra and a correlation between the two spectroscopies indicates that Nd{sup 3+}-Nd{sup 3+} exchange and dipolar interactions occur in the zircon family, even at very low doping content (less than 8 x 10{sup 19} Nd{sup 3+} ions cm{sup -3}). Nd{sup 3+}-Nd{sup 3+} pairs at distances 3.9, 5.9 and 6.3 A have been identified. (orig.) 13 refs.
1998-07-24
Crystal field and EPR studies of Nd"3"+:YMO_4(M=V,AS,P)
International Nuclear Information System (INIS)
Crystal field calculation and electron paramagnetic resonance (EPR) have been performed on zircon-type materials Nd:YMO_4 (M=V, As, P). Simulation of the energy level schemes has been carried out and the wave functions composition and g tensor principal values associated to the first sub-level of the "4I_9_/_2 manifold were calculated. A rather good correlation is obtained between crystal field calculations and the EPR measurements. Furthermore, some extra lines observed by optical spectroscopy (absorption and emission) also appear on the EPR spectra and a correlation between the two spectroscopies indicates that Nd"3"+-Nd"3"+ exchange and dipolar interactions occur in the zircon family, even at very low doping content (less than 8 x 10"1"9 Nd"3"+ ions cm"-"3). Nd"3"+-Nd"3"+ pairs at distances 3.9, 5.9 and 6.3 A have been identified. (orig.)
1998-07-24
Energy Technology Data Exchange (ETDEWEB)
This report describes the 5 tasks to be covered under this project and compiles budget information. Task 1 is to establish a Plutonium Information Resource, which has been established in Amarillo, Texas. Task 2, Advisory Functions, coordinates studies and activities relating to the disposition of excess weapons-grade plutonium. Task 3, Environmental, Public Health, and Safety, supports soil remediation activities. Task 4, Education and Outreach, is supporting four programs: K--12 education improvement in science and math courses; Academic intervention to identify and encourage high ability high school and middle school students with potential to become scientists and engineers; Graduate education evaluation; and Public outreach programs. Task 5, Plutonium and other Materials Studies, is currently funding two projects for the disposition of high explosives: a feasibility study of burning a mixture of high explosives and other materials in a ...
1995-06-29
Cavitation guide for control valves
Energy Technology Data Exchange (ETDEWEB)
This guide teaches the basic fundamentals of cavitation to provide the reader with an understanding of what causes cavitation, when it occurs, and the potential problems cavitation can cause to a valve and piping system. The document provides guidelines for understanding how to reduce the cavitation and/or select control valves for a cavitating system. The guide provides a method for predicting the cavitation intensity of control valves, and how the effect of cavitation on a system will vary with valve type, valve function, valve size, operating pressure, duration of operation and details of the piping installation. The guide defines six cavitation limits identifying cavitation intensities ranging from inception to the maximum intensity possible. The intensity of the cavitation at each limit Is described, including a brief discussion of how each level of cavitation influences the valve and system. Examples are included to demonstrate how to ...
1993-04-01
An adaptive filter to approximate the Bayesian strategy for sonographic beamforming.
A first-principles task-based approach to the design of medical ultrasonic imaging systems for breast lesion discrimination is described. This study explores a new approximation to the ideal Bayesian observer strategy that allows for object heterogeneity. The new method, called iterative Wiener filtering, is implemented using echo data simulations and a phantom study. We studied five lesion features closely associated with visual discrimination for clinical diagnosis. A series of human observer measurements for the same image data allowed us to quantitatively compare alternative beamforming strategies through measurements of visual discrimination efficiency. Employing the Smith-Wagner model observer, we were able to breakdown efficiency estimates and identify the processing stage at which performance losses occur. The methods were implemented using a commercial scanner and a cyst phantom to explore development of spatial filters for systems with shift-variant ...
2010-07-19
Energy Technology Data Exchange (ETDEWEB)
As part of developing efforts for physical exploration technologies for oil reservoirs, this paper describes development of an active seismic while drilling (SWD). The SWD is a seismic exploration method to acquire records equivalent to VSP using seismic waves generated from a bit executing excavation, and is capable of detection and control on a real time basis during the excavation. However, the drawback is that it is subjected to a limitation in the bit. To eliminate this limitation, an artificial seismic source method was devised. In other words, this is an SWD utilizing an artificial seismic source. The contrivance is such that a shot sub containing a magnetic distortion oscillator is attached directly above a bit to generate vibration artificially, and try to utilize larger seismic energy by combining this vibration with that generated from the excavating bit. Frequency band in the seismic source is as narrow as nearly a single frequency waveform. Preparing a time-depth curve ...
1997-05-27
A Global Framework for Monitoring Phenological Responses to Climate Change
Energy Technology Data Exchange (ETDEWEB)
Remote sensing of vegetation phenology is an important method with which to monitor terrestrial responses to climate change, but most approaches include signals from multiple forcings, such as mixed phenological signals from multiple biomes, urbanization, political changes, shifts in agricultural practices, and disturbances. Consequently, it is difficult to extract a clear signal from the usually assumed forcing: climate change. Here, using global 8 km 1982 to 1999 Normalized Difference Vegetation Index (NDVI) data and an eight-element monthly climatology, we identified pixels whose wavelet power spectrum was consistently dominated by annual cycles and then created phenologically and climatically self-similar clusters, which we term phenoregions. We then ranked and screened each phenoregion as a function of landcover homogeneity and consistency, evidence of human impacts, and political diversity. Remaining phenoregions represented areas with a ...
2005-02-01
Energy Technology Data Exchange (ETDEWEB)
Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiological disorder of early childhood onset. Defining symptoms are chronic impairments of attention, impulse control and motor hyperactivity that frequently persist until adulthood. Miscellaneous causes of the disorder have been discussed. Accumulating evidence from imaging- and molecular genetic studies strengthened the theory of ADHS being a predominantly inherited disorder of neurobiological origin. In the last 15 years, non-invasive brain imaging methods were successfully implemented in pediatric research. Functional magnetic resonance imaging studies gave major insight into the neurobiological correlates of executive malfunction, inhibitory deficits and psychomotoric soft signs. These findings are in good accordance with brain morphometric data indicating a significant volumetric decrease of major components of striato-thalamo-cortical feedback loops, primarily influencing prefrontal executive ...
2005-02-01
Verification and testing of the RTOS for safety-critical embedded systems
Energy Technology Data Exchange (ETDEWEB)
Development in Instrumentation and Control (I and C) technology provides more convenience and better performance, thus, adopted in many fields. To adopt newly developed technology, nuclear industry requires rigorous V and V procedure and tests to assure reliable operation. Adoption of digital system requires verification and testing of the OS for licensing. Commercial real-time operating system (RTOS) is targeted to apply to various, unpredictable needs, which makes it difficult to verify. For this reason, simple, application-oriented realtime OS is developed for the nuclear application. In this work, we show how to verify the developed RTOS at each development lifecycle. Commercial formal tool is used in specification and verification of the system. Based on the developed model, software in C language is automatically generated. Tests are performed for two purposes; one is to identify consistency between the verified model and the generated code, the other is to ...
2003-07-01
Verification and testing of the RTOS for safety-critical embedded systems
International Nuclear Information System (INIS)
Development in Instrumentation and Control (I and C) technology provides more convenience and better performance, thus, adopted in many fields. To adopt newly developed technology, nuclear industry requires rigorous V and V procedure and tests to assure reliable operation. Adoption of digital system requires verification and testing of the OS for licensing. Commercial real-time operating system (RTOS) is targeted to apply to various, unpredictable needs, which makes it difficult to verify. For this reason, simple, application-oriented realtime OS is developed for the nuclear application. In this work, we show how to verify the developed RTOS at each development lifecycle. Commercial formal tool is used in specification and verification of the system. Based on the developed model, software in C language is automatically generated. Tests are performed for two purposes; one is to identify consistency between the verified model and the generated code, the other is to ...
2003-05-29
Using benchmarking to minimize common DOE waste streams: Volume 5. Office paper waste
Energy Technology Data Exchange (ETDEWEB)
Finding innovative ways to reduce waste streams generated at US Department of Energy (DOE) sites by 50% by the year 2000 is a challenge for DOE`s waste minimization efforts. A team composed of members from several DOE facilities used the quality tool known as benchmarking to improve waste minimization efforts. First the team examined office waste generation and handling processes at their sites. Then team members developed telephone and written questionnaires to help identify potential ``best-in-class`` industry partners willing to share information about their best waste minimization techniques and technologies. The team identified two benchmarking partners, NIKE, Inc., in Beaverton, Oregon, and Microsoft, Inc., in Redmond, Washington. Both companies have proactive, employee-driven environmental issues programs. Both companies report strong employee involvement, management commitment, and readily available markets for recyclable materials such ...
1995-10-01
Energy Technology Data Exchange (ETDEWEB)
Biodegradable and green plastics are the new tendency in the world. The effect of the electron beam irradiation in aromatic aliphatic copolyester and the blend with corn starch films (Ecoflex{sup R} and Ecobras{sup R}) were studied by tensile strength at break, elongation at break, Scanning Electronic Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), crosslinking degree and biodegradability. The measurements in both, the machine direction and the transverse direction were made for mechanical tests. It was found that, the electron irradiation caused an increase in the strength at break of the blend with corn starch film, when doses of up to 10 kGy were applied. A significant decrease of the elongation at break of the blend with corn starch was observed at doses of 10 kGy and 40 kGy. It was not found important change in tensile properties for aromatic aliphatic copolyester. Structural changes of the samples (crosslinking or ...
2008-07-01
International Nuclear Information System (INIS)
Biodegradable and green plastics are the new tendency in the world. The effect of the electron beam irradiation in aromatic aliphatic copolyester and the blend with corn starch films (Ecoflex"R and Ecobras"R) were studied by tensile strength at break, elongation at break, Scanning Electronic Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), crosslinking degree and biodegradability. The measurements in both, the machine direction and the transverse direction were made for mechanical tests. It was found that, the electron irradiation caused an increase in the strength at break of the blend with corn starch film, when doses of up to 10 kGy were applied. A significant decrease of the elongation at break of the blend with corn starch was observed at doses of 10 kGy and 40 kGy. It was not found important change in tensile properties for aromatic aliphatic copolyester. Structural changes of the samples (crosslinking or degradation) by ...
Gas Storage Technology Consortium
Energy Technology Data Exchange (ETDEWEB)
Gas storage is a critical element in the natural gas industry. Producers, transmission and distribution companies, marketers, and end users all benefit directly from the load balancing function of storage. The unbundling process has fundamentally changed the way storage is used and valued. As an unbundled service, the value of storage is being recovered at rates that reflect its value. Moreover, the marketplace has differentiated between various types of storage services and has increasingly rewarded flexibility, safety, and reliability. The size of the natural gas market has increased and is projected to continue to increase towards 30 trillion cubic feet over the next 10 to 15 years. Much of this increase is projected to come from electric generation, particularly peaking units. Gas storage, particularly the flexible services that are most suited to electric loads, is crucial in meeting the needs of these new markets. To address the gas storage needs of the ...
2007-06-30
Field investigation of radio network usage at the dismounted infantry section level
The Soldier Information Requirements Technology Demonstration (SIREQ TD) project is an experimentation program to identify technologies that significantly enhance the performance of our future soldiers. One of the study series involved a 2 x 2 factorial comparison of the benefits of digital maps over paper maps, and the use of radios vs. no radios. Thirty-two Canadian regular force infantry soldiers performed force-on-force tactical assault missions in wooded terrain, with each soldier participating in all four test conditions. The radios were configured to operate in 4 subnets: 1 channel for each of the 2 Assault Groups (4 soldiers on a channel); a Section Commander/2IC channel; and an all-users channel. Note that in the no-radio conditions soldiers still operated the press-to-talk switch to allow recording of communications, but the speaker volume was set to zero. All communications were date/time stamped, identified as to the user and ...
2006-06-01
Brain mechanisms supporting the modulation of pain by mindfulness meditation.
The subjective experience of one's environment is constructed by interactions among sensory, cognitive, and affective processes. For centuries, meditation has been thought to influence such processes by enabling a nonevaluative representation of sensory events. To better understand how meditation influences the sensory experience, we used arterial spin labeling functional magnetic resonance imaging to assess the neural mechanisms by which mindfulness meditation influences pain in healthy human participants. After 4 d of mindfulness meditation training, meditating in the presence of noxious stimulation significantly reduced pain unpleasantness by 57% and pain intensity ratings by 40% when compared to rest. A two-factor repeated-measures ANOVA was used to identify interactions between meditation and pain-related brain activation. Meditation reduced pain-related activation of the contralateral primary somatosensory cortex. Multiple regression ...
2011-04-01
Multi-functional Biocompatible Coatings
International Science & Technology Center (ISTC)
Multi-functional Bioactive Nano-structured Coatings for Load-Bearing Implants
A High Throughput Combinatorial Library Technique for Identifying Formalin-Sensitive Epitopes
UK PubMed Central (United Kingdom)
We present a technique for identifying the amino acids responsible for a loss of immunoreactivity in response to treating an antigen with a chemical modifier. This is of particular interest...Full Text Available
2006-12-20
Energy Technology Data Exchange (ETDEWEB)
ABSTRACT-Here we identify release of annexin A2 into the culture medium in response to low dose X-ray radiation exposure and establish functional linkages to an established paracrine factor-mediated anchorage-independent growth response. Using a standard bicameral coculture model, we observe that annexin A2 levels associated with non-irradiated neighboring cells seeded in the lower chamber (annexin A2 silenced [shRNA] JB6 cells) are increased upon coculture with irradiated (10-50 cGy) JB6 cells seeded in the upper chamber, relative to coculture with sham exposed JB6 cells seeded in the upper chamber, suggesting that annexin A2 released into the medium is capable of communicating in a paracrine fashion. Using a previously established coculture model, we observed that the paracrine factor-mediated anchorage-independent growth response to low dose X-ray radiation is markedly reduced when irradiated annexin A2 silenced (shRNA) JB6 cells are used, ...
2009-07-13
International Nuclear Information System (INIS)
ADP-ribosylation factors (ARFs) are small guanine nucleotide-binding proteins that enhance the enzymatic activities of cholera toxin. Two ARF cDNAs, ARF1 and ARF3, were cloned from a human cerebellum library. Based on deduced amino acid sequences and patterns of hybridization of cDNA and oligonucleotide probes with mammalian brain poly(A)"+ RNA, human ARF1 is the homologue of bovine ARF1. Human ARF3, which differs from bovine ARF1 and bovine ARF2, appears to represent a newly identified third type of ARF. Hybridization patterns of human ARF cDNA and clone-specific oligonucleotides with poly(A)"+ RNA are consistent with the presence of at least two, and perhaps four, separate ARF messages in human brain. In vitro translation of ARF1, ARF2, and ARF3 produced proteins that behaved, by SDS/PAGE, similar to a purified soluble brain ARF. Deduced amino acid sequences of human ARF1 and ARF3 contain regions, similar to those in other G proteins, that are believed to be ...
1989-01-01
In vitro atrazine-exposure inhibits human natural killer cell lytic granule release
International Nuclear Information System (INIS)
The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test this hypothesis, flow cytometry and fluorescent microscopy were employed to analyze NK cell-target cell co-cultures following atrazine ...
2007-06-01
Fundamental Elements of Geologic C02 Sequestration in Saline Aquifers
Energy Technology Data Exchange (ETDEWEB)
Geologic sequestration represents a promising strategy for isolating CO{sub 2} waste streams from the atmosphere. Successful implementation of this approach hinges on our ability to predict the relative effectiveness of subsurface CO{sub 2} migration and sequestration as a function of key target-formation and cap-rock properties, which will enable us to identify optimal sites and evaluate their long-term isolation performance. Quantifying this functional relationship requires a modeling capability that explicitly couples multiphase flow and kinetically controlled geochemical processes. We have developed a unique computational package that meets these criteria, and used it to model CO{sub 2} injection at Statoil's North-Sea Sleipner facility, the world's first saline-aquifer storage site. The package integrates a state-of-the-art reactive transport simulator (NUFT) with supporting geochemical software and ...
2001-11-19
International Nuclear Information System (INIS)
Radiation chimeras in the early phase after bone marrow transplantation are a good model to study the efficiency of the body's nonspecific defense system represented by macrophages (M phi), polymorphonuclear cells (PMN), and NK cells. These cell types are present in large numbers in spleen and liver at that time, whereas the specific immune system represented by T and B cells is functionally deficient. We previously reported enhanced activities in vitro of M phi (and PMN) from recipient animals in an early phase after allogeneic bone marrow transfer. We here demonstrate that these activities result in enhanced spontaneous resistance against Listeria monocytogenes in vivo: CFU of L. monocytogenes in spleen and liver 48 h after infection were about 1 or 2 to 4 log steps less than in untreated control mice of donor or host haplotype. This enhanced resistance decreased over the 4-mo period after marrow transfer. Preactivated M phi were identified ...
Data of spleen-scintiscanning after splenectomy
International Nuclear Information System (INIS)
In 65 adult rabbits of both sexes (2.5 to 6 kg) the following salvaging procedures were performed after simulated trauma: (1) Continuous suture line; (2) closure with fibrin sealant after temporary clamping; (3) hemisplenectomy with omental wrap; (4) suture fixation of fragments and slices of spleen tissue to the peritoneum; (5) suture fixation of spleen fragments to the omentum; (6) extraperitoneal subcutaneous transposition of spleen cubes. In addition, the likelihood of spontaneous splenosis was examined in a preliminary study involving 5 animals by introducing unattached spleen meal and fragments. Scanning was repeated 4 to 12 weeks postoperatively. The functional competence of minor parenchymal islands was also investigated with well counter measurements of organ and muscle tissue homogenates. Spontaneous splenosis after abdominal injuries was not found to be the rule. Salvaging procedures at the natural vascular hilus by sutures, fibrin sealant and ...
Climate change, agriculture and wetlands in Eastern Europe: vulnerability, adaptation and policy
Energy Technology Data Exchange (ETDEWEB)
Naturally-occurring wetlands perform such functions as flood control, pollution filtration, nutrient recycling, sediment accretion, groundwater recharge and water supply, erosion control, and plant and wildlife preservation. A large concentration of wetlands is located in Eastern Europe. A significant amount of Eastern European wetlands has been converted to agricultural use in the past, and remaining wetlands are subject to agricultural drainage. Drained wetlands are used as prime agriculture lands for a variety of food crops. Other agricultural uses of wetlands range from growing Phragmites australis (common reed) for thatch and livestock feed, to collecting peat for heating and cooking fuel. Altered hydrologic regimes due to global climate change could further exacerbate encroachment of agricultural land use into wetlands. The vulnerability and adaptation studies of the US Country Studies Program are used to analyze where climate change impacts to agriculture ...
1997-05-01
DEFF Research Database (Denmark)
PURPOSE OF REVIEW: To review the recent literature on the prognostic value of biomarkers of liver fibrosis and impaired liver function in patients with chronic hepatitis C with or without HIV coinfection. RECENT FINDINGS: A combination of standard blood tests seems to be useful in identifying patients at risk of liver-related complications. Findings from studies investigating the validity of the Model for End-Stage Liver Disease (MELD) score in HIV-infected liver transplant candidates are conflicting. Two large studies of HIV/hepatitis C virus (HCV) coinfected patients have shown that plasma levels of the fibrosis marker hyaluronic acid are a strong predictor of clinical complications. A smaller study found hyaluronic acid and two other fibrosis tests, aspartate aminotransferase-to-platelet ratio index (APRI) and Fib-4, to be independent predictors of mortality when included in models with the MELD or the Child-Pugh-Turcotte scores. SUMMARY: ...
2010-01-01
BS in Ceramic and Materials Engineering at Clemson
Description of courses, curriculum and degree program. "Ceramic and materials engineers design, develop, and participate in the manufacture of both standard and new materials intended for use in a wide variety of industries with diverse applications. These range from the semi-conductor to the aerospace and finally to the traditional ceramics industry. The broad scope of industrial responsibilities handled by ceramic and materials engineers requires knowledge in mathematics, science, engineering, and the social sciences, skills in problem solving, engineering analysis, design, and written and oral communication. The baccalaureate program integrates laboratory with classroom experiences to prepare students for life-long learning. Courses covering thermodynamics, kinetics, mechanical behavior, processing and characterization of materials prepare students for careers in industry and/or for graduate school. Clemson University baccalaureate graduates in Ceramic and Materials Engineering, ...
2007-01-01
Energy Technology Data Exchange (ETDEWEB)
The objective of this research project is to demonstrate sensing, communication, information and control technologies to achieve a seamless integration of multivendor distributed energy resource (DER) units at aggregation levels that meet individual user requirements for facility operations (residential, commercial, industrial, manufacturing, etc.) and further serve as resource options for electric and natural gas utilities. The fully demonstrated DER aggregation system with embodiment of communication and control technologies will lead to real-time, interactive, customer-managed service networks to achieve greater customer value. Work on this Advanced Communication and Control Project (ACCP) consists of a two-phase approach for an integrated demonstration of communication and control technologies to achieve a seamless integration of DER units to reach progressive levels of aggregated power output. Phase I involved design and proof-of-design, and Phase II involves real-world ...
2008-09-30
Report on breast milk examinations carried out in Lower Saxony from 1987 until 1990
International Nuclear Information System (INIS)
In the group of persistent aromatic hydrocarbons, the highest values were determined for polychlorinated biphenyls (PCB), total DDT and hexachlorobenzene (HBC). Comparisons of the relevant median values for the past six years led to the conclusion that the steep initial decline in the breast milk concentrations of DDT and HBC was followed by reductions at a much lower pace in the years after 1987. The time course of the concentration of the total PCB did not appear to follow any particular pattern. The mean contents of lead and cadmium remained by a wide margin below the threshold values for these heavy metals and thus were of no relevance from the toxicological point of view. It was found that the 134 and 137 cesium isotopes constituted no particular health hazard for breast-fed infants, as the relevant concentrations in breast milk were low. (VHE).
Several examples of agonist-directed trafficking of receptor signalling at 5-HT2A and 5-HT2C receptors have been reported that involve independent downstream transduction pathways. We now report the functional selectivity of a series of chemically diverse agonists at human (h)5-HT2A, h5-HT2B and h5-HT2C-VSV by examining two related responses, the upstream activation of Gq/11 proteins in comparison with its associated cascade of calcium mobilisation. At the h5-HT2A receptor, d-lysergic acid diethylamide (LSD) and the antiparkinsonian agents lisuride, bromocriptine and pergolide exhibit a higher potency for Gq/11 activation than calcium release in contrast with all the other tested ligands such as 5-HT, mCPP and BW723C86, that show an opposite preference of signalling pathway. Comparable observations are made at h5-HT2B and h5-HT2C-VSV receptors, suggesting a similar mechanism of functional selectivity for the three serotonin receptors. ...
2008-07-30
Asymptotic numbers, asymptotic functions and distributions
International Nuclear Information System (INIS)
The asymptotic functions are a new type of generalized functions. But they are not functionals on some space of test-functions as the distributions of Schwartz. They are mappings of the set denoted by A into A, where A is the set of the asymptotic numbers introduced by Christov. On its part A is a totally-ordered set of generalized numbers including the system of real numbers R as well as infinitesimals and infinitely large numbers. Every two asymptotic functions can be multiplied. On the other hand, the distributions have realizations as asymptotic functions in a certain sense. (author).
2007-05-18
Tissue Effect on Genetic Control of Transcript Isoform Variation
UK PubMed Central (United Kingdom)
Current genome-wide association studies (GWAS) are moving towards the use of large cohorts of primary cell lines to study a disease of interest and to assign biological relevance to the genetic signals...Full Text Available
2009-08-01
The potential risks of nanomaterials: a review carried out for ECETOC
UK PubMed Central (United Kingdom)
During the last few years, research on toxicologically relevant properties of engineered nanoparticles has increased tremendously. A number of international research projects and additional activities...Full Text Available
The Pseudomonas aeruginosa PA01 Gene Collection
UK PubMed Central (United Kingdom)
Pseudomonas aeruginosa, a common inhabitant of soil and water, is an opportunistic pathogen of growing clinical relevance. Its genome, one of the largest among bacteria [5570 open reading...Full Text Available
2004-10-01
Teaching, learning, and leading.
Instructional systems design is a process for assessing learning needs, creating instructional programs, and evaluating effectiveness of learning. We discuss the benefits of including instructional systems design theory and practice in the curriculum, with an emphasis on making the process relevant for student nurse anesthetists. PMID:10488275
1999-02-01
UK PubMed Central (United Kingdom)
The quantitative experimental uncertainty in the structure of fully hydrated, biologically relevant, fluid (Lα) phase lipid bilayers has been too large to...Full Text Available
2000-11-10
UK PubMed Central (United Kingdom)
The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid...Full Text Available
1992-01-01
UK PubMed Central (United Kingdom)
Mouse lines with behavioral phenotypes relevant to symptoms in neurodevelopmental disorders may provide models to test hypotheses about disease etiology and to evaluate potential treatments....Full Text Available
2010-03-17
UK PubMed Central (United Kingdom)
BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive...Full Text Available
Self-management among Patients Living with Diabetes in the United States Virgin Islands
UK PubMed Central (United Kingdom)
The United States Virgin Islands (USVI) is facing a diabetes epidemic similar to the one on the U.S. mainland, yet little is known regarding the cultural context relevant to self-management...Full Text Available
2011-01-01
UK PubMed Central (United Kingdom)
The objectives of this research are: (1) to assess selected formulation-relevant physical properties of several commercial Feverfew extracts, including flowability, hygroscopicity, compressibility and...Full Text Available
Saffold Cardiovirus in Children with Acute Gastroenteritis, Beijing, China
UK PubMed Central (United Kingdom)
To understand Saffold cardiovirus (SAFV) distribution, prevalence, and clinical relevance in China, we retrospectively studied SAFV in children with acute gastroenteritis and found SAFV in 12 (3.2%)...Full Text Available
2009-09-01
Energy Technology Data Exchange (ETDEWEB)
The planned spallation source can be of considerable significance for biomedical basic research and for clinically relevant diagnostic and therapeutic applications. The following gives a brief description and explanations for its possible use in clinical medicine: I. Treatment of Malignant Tumors II. Production of Isotopes for Biochemical Investigations in Living Organisms for Diagnostic Purposes.
1984-12-01
UK PubMed Central (United Kingdom)
BackgroundTransarterial chemoembolization (TACE) therapy is an effective locoregional treatment in hepatocellular cancer (HCC) patients. For early modification of therapy, markers...Full Text Available
UK PubMed Central (United Kingdom)
Plasmid transfer between strains of Bacillus thuringiensis subsp. israelensis was studied under a range of environmentally relevant laboratory conditions in vitro,...Full Text Available
2001-01-01
Music perception in cochlear implant users and its relationship with psychophysical capabilities
UK PubMed Central (United Kingdom)
This article describes issues concerning music perception with cochlear implants, discusses why music perception is usually poor in cochlear implant users, reviews relevant data, and describes...Full Text Available
2008-01-01
Monthly energy review, May 1993
Energy Technology Data Exchange (ETDEWEB)
The Monthly Energy Review provides an overview of the production, distribution, and consumption of energy derived from petroleum natural gas, coal, electricity, and nuclear energy. It also discusses oil and gas resource development, energy prices, and issues relevant to international energy markets.
1993-05-01
Monitoring potential neurotoxic effects of hazardous waste disposal
UK PubMed Central (United Kingdom)
This report reviews neurotoxicological principles relevant to situations of hazardous waste disposal. Some of the diagnostic techniques currently used for field assessment of nervous system dysfunction...Full Text Available
1983-02-01
UK PubMed Central (United Kingdom)
BackgroundThoracic injuries play an important role in major trauma patients due to their high incidence and critical relevance. A serious consequence of thoracic trauma is pneumothorax,...Full Text Available
Increasing the opportunities for UK-Canada collaboration
International Nuclear Information System (INIS)
This paper outlines the opportunities for UK-Canada collaboration/feasibility studies in areas that include novel research into waste management and decommissioning. A number of Universities in the UK have programs relevant to such collaborations in areas such as fuels; thermal hydraulics, reactor system and materials.
2007-06-03
Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation
UK PubMed Central (United Kingdom)
Ethnopharmacological relevanceHLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases....Full Text Available
2009-05-04
Face or building superiority in peripheral vision reversed by task requirements
UK PubMed Central (United Kingdom)
Peripheral vision has been the topic of few studies compared with central vision. Nevertheless, given that visual information covers all the visual field and that relevant information can...Full Text Available
Evidence for modular evolution in a long-tailed pterosaur with a pterodactyloid skull
UK PubMed Central (United Kingdom)
The fossil record is a unique source of evidence for important evolutionary phenomena such as transitions between major clades. Frustratingly, relevant fossils are still comparatively rare, most transitions...Full Text Available
2010-02-07
Recommended ERLs for whole body, thyroid, lung and other single organs are presented in tabular form, and related to the relevant counter measures such as evacuation, sheltering, distribution of stable iodine tablets, etc. Application of ERLs to local env...
1981-01-01
Ecological relevance of air pollution abatement measures as a decision aid
Energy Technology Data Exchange (ETDEWEB)
Air pollution abatement measures are not an end in themselves, and undesirable side effects should be taken into account. The proposed emission index takes into account the total emissions caused by a technical project as well as the effects of the individual pollutants.
1983-01-01
UK PubMed Central (United Kingdom)
Spatial abilities have been associated with many ecologically-relevant behaviors such as territoriality, mate choice, navigation and acquisition of food resources. Differential demands on spatial...Full Text Available
2009-07-01
Dissecting the Genetic Components of Adaptation of Escherichia coli to the Mouse Gut
UK PubMed Central (United Kingdom)
While pleiotropic adaptive mutations are thought to be central for evolution, little is known on the downstream molecular effects allowing adaptation to complex ecologically relevant environments. Here...Full Text Available
2008-01-01
UK PubMed Central (United Kingdom)
BackgroundIn sub-Saharan Africa, Plasmodium falciparum malaria in pregnancy presents an enormous diagnostic challenge. The epidemiological and clinical relevance...Full Text Available
UK PubMed Central (United Kingdom)
Despite their wide use, the physiological relevance of organotypic slices remains controversial. Such cultures are prepared at 5 days postnatal. Although some local circuitry remains intact, they develop...Full Text Available
2003-07-01
UK PubMed Central (United Kingdom)
We introduce cyclophosphamide-induced alopecia (CYP-IA) in C57BL-6 mice as a clinically relevant model for studying the biology of chemotherapy-induced alopecia and for developing anti-alopecia drugs....Full Text Available
1994-04-01
UK PubMed Central (United Kingdom)
BackgroundTwo clinically relevant high-risk HPV (HR-HPV) types 16 and 18 are etiologically associated with the development of cervical carcinoma and are also reported to be present...Full Text Available
Bacterial Artificial Chromosome Mutagenesis Using Recombineering
UK PubMed Central (United Kingdom)
Gene expression from bacterial artificial chromosome (BAC) clones has been demonstrated to facilitate physiologically relevant levels compared to viral and nonviral cDNA vectors. BACs are large enough...Full Text Available
2011-01-01
A global optimization algorithm for protein surface alignment
UK PubMed Central (United Kingdom)
BackgroundA relevant problem in drug design is the comparison and recognition of protein binding sites. Binding sites recognition is generally based on geometry often combined with...Full Text Available
British Library Electronic Table of Contents (United Kingdom)
Problems of classification and regression estimation in which objects are represented by multidimensional arrays of features are considered. Many practical statements can be reduced to such problems, for example, the popular approach to the description of images as a set of patches and a set of descriptors in each patch or the description of an object in the form of a set of distances from it to certain support objects selected based on a set of features. For solving problems concerning the objects thus described, a generalization of the relevance vector model is proposed. In this generalization, specific regularization coefficients are defined for each dimension of the multidimensional array of the object description; the resultant regularization coefficient for a given element in the mul...
2011-01-01
This paper explores how an aid-funded Ph.D.-programme in mathematics education instituted in some Southern African Development Community countries measures up to issues related to research capacity development projects. The research capacity development programme is described and reflected against mutual benefit, relevance, sustainability and prioritization of the location of project funding expenditure--some of the constructs in the discourse on research capacity development initiatives. It is found that the benefits of the programme are indeed mutual; the outcomes regarding relevance and sustainability are more uncertain and the location of expenditure of the funding is not overtly in favour of the donor country.
2005-11-01
Anaerobic oxidation of carbon steel in granitic groundwaters: A review of the relevant literature
International Nuclear Information System (INIS)
This report reviews the published literature on the anaerobic oxidation of iron in aqueous solutions which are of particular relevance to Swedish granitic groundwaters. The thermodynamics of iron corrosion in water are briefly considered. Following this the experimental data found in the literature are presented and discussed. Results were found for corrosion of iron in both pure water and solutions containing mineral salts. The literature work in the nature of the films formed on iron surfaces under anaerobic conditions is reviewed and the possible mechanisms of film formation are discussed. Conclusions are drawn on the factors most likely to influence and control film growth. 32 refs.
2010-02-01
Energy Technology Data Exchange (ETDEWEB)
This assessment is a feasibility study according to ISO 14024. It deals with the question whether an ecolabel is suitable for wood pellet heating systems and how concrete criteria for an ecolabel for wood pellet heating plants could be specified. The study begins with a comprehensive market analysis in order to identify possible plants for which an ecolabel would make sense. In the main part of the study, the environmental relevance of the chosen plants is analysed. For this analysis, plant manufacturers were interviewed and a comparison between wood pellet heating systems and heating systems which use gas, oil or wood was carried out. On the basis of this analysis, it was possible to derive a number of criteria which were discussed with company representatives and other experts in this field. As a result of this dialogue and the investigation process as a whole, the introduction of an ecolabel for wood pellet heating plants can be recommended. ...
2002-07-01
As both computer and mobile phone reach nearly ubiquity in the U.S. market, the slow uptake of mobile video, in contrast to the thriving usage of PC-based video, warrants a deeper understanding of user-oriented factors contributing to the two diffusion paths. Unlike the majority of existing diffusion research practices, the dissertation examines the differences between mobile and PC video diffusion patterns through the lenses of user-oriented influences in the user-technology relationship. Built upon the established adoption user group classification, the research is informed by the Uses and Gratification theory, the Social Technical theory, and the Technical Affordance perspective. These synergistic theoretical arguments share the recognition of the role of user in the dynamic, usually socially intertwined user-technology interactions. The key research questions that the dissertation sets out to answer include: Does the importance of quality of viewing experience in adoption ...
2009-12-01
ALASKA OIL AND GAS EXPLORATION, DEVELOPMENT, AND PERMITTING PROJECT
Energy Technology Data Exchange (ETDEWEB)
The objective of this project is to eliminate three closely inter-related barriers to oil production in Alaska through the use of a geographic information system (GIS) and other information technology strategies. These barriers involve identification of oil development potential from existing wells, planning projects to efficiently avoid conflicts with other interests, and gaining state approvals for exploration and development projects. Each barrier is the result of either current labor-intensive methods or poorly accessible information. This project brings together three parts of the oil exploration, development, and permitting process to form the foundation for a more fully integrated information technology infrastructure for the State of Alaska. This web-based system will enable the public and other review participants to track permit status, submit and view comments, and obtain important project information online. By automating several functions of the ...
2003-08-04
Wave function of an anisotropic universe
Energy Technology Data Exchange (ETDEWEB)
The wave function of the Bianchi type-IX universe with small anisotropy is calculated using the Hartle-Hawking prescription.
1985-06-15
Wave function of an anisotropic universe
International Nuclear Information System (INIS)
The wave function of the Bianchi type-IX universe with small anisotropy is calculated using the Hartle-Hawking prescription.
Overview on some functional issues related to the uninterrupible power systems design
Overview on some functional issues related to the uninterrupible power systems design
1989-01-01
Spline functions associated with a general linear differential operator L which interpolate prescribed data with respect to arbitrary linear functionals are investigated. (Author)
1968-01-01
Prediction of Corrosion of Advanced Materials and Fabricated Components
Energy Technology Data Exchange (ETDEWEB)
The goal of this project is to provide materials engineers, chemical engineers and plant operators with a software tool that will enable them to predict localized corrosion of process equipment including fabricated components as well as base alloys. For design and revamp purposes, the software predicts the occurrence of localized corrosion as a function of environment chemistry and assists the user in selecting the optimum alloy for a given environment. For the operation of existing plants, the software enables the users to predict the remaining life of equipment and help in scheduling maintenance activities. This project combined fundamental understanding of mechanisms of corrosion with focused experimental results to predict the corrosion of advanced, base or fabricated, alloys in real-world environments encountered in the chemical industry. At the heart of this approach is the development of models that predict the fundamental parameters that control the ...
2007-09-29
Heteroepitaxial growth of In-face InN on GaN (0001) by plasma-assisted molecular-beam epitaxy
International Nuclear Information System (INIS)
The thermodynamic aspects of indium-face InN growth by radio frequency plasma-assisted molecular-beam epitaxy (rf-MBE) and the nucleation of InN on gallium-face GaN (0001) surface were investigated. The rates of InN decomposition and indium desorption from the surface were measured in situ using reflected high-energy electron diffraction and the rf-MBE 'growth window' of In-face InN (0001) was identified. It is shown that sustainable growth can be achieved only when the arrival rate of active nitrogen species on the surface is higher than the arrival rate of indium atoms. The maximum substrate temperature permitting InN growth as a function of the active nitrogen flux was determined. The growth mode of InN on Ga-face GaN (0001) surface was investigated by reflected high-energy electron diffraction and atomic force microscopy. It was found to be of the Volmer-Weber-type for substrate temperatures less than 350 deg. C and of the ...
2005-06-01
Traces of evidence. Nuclear forensics and illicit trafficking
International Nuclear Information System (INIS)
An IAEA databank lists a number of reported cases of illicitly trafficked nuclear or other radioactive materials. Apart from the traditional concern with nuclear proliferation, the post September 11th public is now wary of a possible attack by terrorists with a nuclear or radiation dispersion device (RDD). Until now, the seized quantities have not been sufficient to manufacture a nuclear explosive device, but they might be enough to construct an RDD. Recognizing the latent global challenge to public health and safety, the G8 States (Japan, USA, Germany, France, UK, Italy, Canada, and Russia) have called for 'joint international efforts to identify and suppress illicit supply' of, and demand for, nuclear material and to deter potential traffickers. One measure gaining in significance is to identify seized material and trace it back to its origin the objective of an emerging science known as nuclear forensics. Repeatedly nuclear or other ...
2003-06-01
Biosphere analyses for the safety assessment SR-Site - synthesis and summary of results
Energy Technology Data Exchange (ETDEWEB)
This report summarises nearly 20 biosphere reports and gives a synthesis of the work performed within the SR-Site Biosphere project, i.e. the biosphere part of SR-Site. SR-Site Biosphere provides the main project with dose conversion factors (LDFs), given a unit release rate, for calculation of human doses under different release scenarios, and assesses if a potential release from the repository would have detrimental effects on the environment. The intention of this report is to give sufficient details for an overview of methods, results and major conclusions, with references to the biosphere reports where methods, data and results are presented and discussed in detail. The philosophy of the biosphere assessment was to make estimations of the radiological risk for humans and the environment as realistic as possible, based on the knowledge of present-day conditions at Forsmark and the past and expected future development of the site. This was achieved by using the best available ...
2010-12-15
Assessment and Forecasting Natural Gas Reserve Appreciation in the Gulf Coast Basin
Energy Technology Data Exchange (ETDEWEB)
Reserve appreciation, also called reserve growth, is the increase in the estimated ultimate recovery (the sum of year end reserves and cumulative production) from fields subsequent to discovery from extensions, infield drilling, improved recovery of in-place resources, new pools, and intrapool completions. In recent years, reserve appreciation has become a major component of total U.S. annual natural gas reserve additions. Over the past 15 years, reserve appreciation has accounted for more than 80 percent of all annual natural gas reserve additions in the U.S. lower 48 states (Figure 1). The rise of natural gas reserve appreciation basically came with the judgment that reservoirs were much more geologically complex than generally thought, and they hold substantial quantities of natural gas in conventionally movable states that are not recovered by typical well spacing and vertical completion practices. Considerable evidence indicates that many reservoirs show significant geological ...
1997-10-01
Unconstrained energy functionals for electronic structure calculations
Energy Technology Data Exchange (ETDEWEB)
The performance of conjugate gradient schemes for minimizing unconstrained energy functionals in the context of electronic structure calculations is studied. The unconstrained functionals allow a straightforward application of conjugate gradients by removing the explicit orthonormality constraints on the quantum-mechanical wave functions. However, the removal of the constraints can lead to slow convergence, in particular when preconditioning is used. The convergence properties of two previously suggested energy functionals are analyzed, and a new functional is proposed, which unifies some of the advantages of the other functionals. A numerical example confirms the analysis.
1998-04-01
p73 protein regulates DNA damage repair.
Although the p53 tumor suppressor is relatively well characterized, much less is known about the functions of other members of the p53 family, p73 and p63. Here, we present evidence that in specific pathological conditions caused by exposure of normal cells to bile acids in acidic conditions, p73 protein plays the predominant role in the DNA damage response. These pathological conditions frequently occur during gastric reflux in the human esophagus and are associated with progression to esophageal adenocarcinoma. We found that despite strong DNA damage induced by bile acid exposure, only p73 (but not p53 and p63) is selectively activated in a c-Abl kinase-dependent manner. The activated p73 protein induces DNA damage repair. Using a human DNA repair PCR array, we identified multiple DNA repair genes affected by p73. Two glycosylases involved in base excision repair, SMUG1 and MUTYH, were characterized and found to be transcriptionally regulated ...
2011-09-01
Waste Handling Shaft concrete liner degradation conclusions and recommendations
International Nuclear Information System (INIS)
The primary function of the Waste Handling Shaft (WHS) at the Waste Isolation Pilot Plant (WIPP) is to permit the transfer of radioactive waste from the surface waste handling building to the underground storage area. It also serves as an intake shaft for small volumes of air during normal storage operations and as an emergency escape route. Part of the construction was the placement of a concrete liner and steel reinforced key in 1984. During a routine shaft inspection in May 1990, some degradation of the WHS concrete liner was observed between the depths of 800 and 900 feet below the ground surface. Detailed investigations of the liner had been carried out by Sandia National Laboratories and by Westinghouse Electric Corporation Waste Isolation Division (WID) through Lankard Materials Laboratory. Observations, reports, and data support the conclusion that the concrete degradation, resulting from attack by chemically aggressive brine, is a localized phenomena. It ...
Virasoro algebra action on integrable hierarchies and Virasoro contraints in matrix models
International Nuclear Information System (INIS)
The action of the Virasoro algebra on integrable hierarchies of non-linear equations and on related objects ('Schroedinger' differential operators) is investigated. The method consists in pushing forward the Virasoro action to the wave function of a hierarchy, and then reconstructing its action on the dressing and Lax operators. This formulation allows one to observe a number of suggestive similarities between the structures involved in the description of the Virasoro algebra on the hierarchies and the structure of conformal field theory on the world-sheet. This includes, in particular, an 'off-shell' hierarchy version of operator products and of the Cauchy kernel. In relation to matrix models, which have been observed to be effectively described by integrable hierarchies subjected to Virasoro constraints, I propose to define general Virasoro-constrained hierarchies also in terms of dressing operators, by certain equations which carry the information of the ...
1991-12-01
The GntR-like protein NorG has been shown to affect Staphylococcus aureus genes involved in the resistance to quinolones and ?-lactams, such as those encoding the NorB and AbcA transporters. To identify the target genes regulated by NorG, we carried out transcriptional profiling assays using S. aureus RN6390 and its isogenic norG::cat mutant. Our data showed that NorG positively affected the transcription of global regulators mgrA, arlS, and sarZ. The three putative drug efflux pump genes most positively affected by NorG were the NorB efflux pump (5.1-fold), the MmpL-like protein SACOL2566 (5.2-fold), and the BcrA-like drug transporter SACOL2525 (5.7-fold). The S. aureus predicted MmpL protein showed 53% homology with the MmpL lipid transporter of Mycobacterium tuberculosis, and the putative SACOL2525 protein showed 87% homology with the bacitracin drug transporter BcrA of Staphylococcus hominis. Two pump genes most negatively affected by NorG were NorC (4-fold) ...
2011-09-01
Thermochemistry of mixed explosives
Energy Technology Data Exchange (ETDEWEB)
In order to predict thermal hazards of high-energy materials, accurate kinetics constants must be determined. Predictions of thermal hazards for mixtures of high-energy materials require measurements on the mixtures, because interactions among components are common. A differential-scanning calorimeter (DSC) can be used to observe rate processes directly, and isothermal methods enable detection of mechanism changes. Rate-controlling processes will change as components of a mixture are depleted, and the correct depletion function must be identified for each specific stage of a complex process. A method for kinetics measurements on mixed explosives can be demonstrated with Composition B is an approximately 60/40 mixture of RDX and TNT, and is an important military explosive. Kinetics results indicate that the mator process is the decomposition of RDX in solution in TNT with a perturbation caused by interaction between the two components. It is ...
1982-01-01
International Nuclear Information System (INIS)
Vacuum glazing consists of an evacuated space between two sheets of glass. Vacuum glazing has a large effect on energy savings in houses and buildings. Vacuum glazing can achieve higher insulating performance than conventional insulated glazing. Nippon Sheet Glass has successfully developed conventional vacuum glazing. In this study we investigated an advanced form of vacuum glazing. Its thermal insulation ability is equivalent to 100 mm thick glass wool thermal insulation. This vacuum glazing contained a SnO_2:F low emissivity surface. The influence of the residual gas in a vacuum space on heat flow is important to performance. For long-term thermal stability, it is very important to maintain vacuum stability. To understand this better, we studied the behavior of outgassing from the inside glass surfaces exposed to an external energy source. We have studied the behavior of outgassing from a glass surface using a Nd:YAG laser (operated at 355 nm wavelength) and Q-mass spectroscopy in ...
2005-06-15
Study of Nitrate Stress in Desulfovibrio vulgaris Hildenborough Using iTRAQ Proteomics
Energy Technology Data Exchange (ETDEWEB)
The response of Desulfovibrio vulgaris Hildenborough (DvH),a sulphate-reducing bacterium, to nitrate stress was examined usingquantitative proteomic analysis. DvH was stressed with 105 m M sodiumnitrate(NaNO3), a level that caused a 50 percent inhibition in growth.The protein profile of stressed cells was compared with that of cellsgrown in the absence of nitrate using the iTRAQ peptide labellingstrategy and tandem liquid chromatography separation coupled with massspectrometry (quadrupoletime-of-flight) detection. A total of 737 uniqueproteins were identified by two or more peptides, representing 22 percentof the total DvH proteome and spanning every functional category. Theresults indicate that this was a mild stress, as proteins involved incentral metabolism and the sulphate reduction pathway were unperturbed.Proteins involved in the nitrate reduction pathway increased. Increasesseen in transport systems for proline, glycine^ ...
2006-10-12
Stochastic analysis of contaminant transport: One-dimensional non-reactive and reactive cases
Energy Technology Data Exchange (ETDEWEB)
A reliability approach for probabilistic modeling of one-dimensional non-reactive and reactive transport in porous media provides two important quantitative results: (1) an estimate of the probability that dimensionless concentration equals or exceeds some specified level and, (2) the sensitivity of the probabilistic outcome to likely changes in each uncertain variable. The reliability approach is particularly attractive because it can incorporate various marginal probability density functions (PDF) for any of the uncertain variables. In this work uncertain variables include: groundwater flow velocity, diffusion coefficient, dispersivity, distribution coefficient, porosity and bulk density. The primary objective is to examine how the probabilistic outcome is influenced by choice of marginal PDF, correlation and magnitude of uncertainty for the variables. Because little information exists concerning the statistical characteristics of these uncertain variables, the ...
1990-12-03
Calcium-activated chloride channels (CaCCs) are widely expressed in mammalian tissues, including intestinal epithelia, where they facilitate fluid secretion. Potent, selective CaCC inhibitors have not been available. We established a high-throughput screen for identification of inhibitors of a human intestinal CaCC based on inhibition of ATP/carbachol-stimulated iodide influx in HT-29 cells after lentiviral infection with the yellow fluorescent halide-sensing protein YFP-H148Q/I152L. Screening of 50,000 diverse, drug-like compounds yielded six classes of putative CaCC inhibitors, two of which, 3-acyl-2-aminothiophenes and 5-aryl-2-aminothiazoles, inhibited by >95% iodide influx in HT-29 cells in response to multiple calcium-elevating agonists, including thapsigargin, without inhibition of calcium elevation, calcium-calmodulin kinase II activation, or cystic fibrosis transmembrane conductance regulator chloride channels. These compounds also inhibited calcium-dependent chloride ...
2007-12-14
Schottky barrier and homojunction gallium arsenide solar cells
Energy Technology Data Exchange (ETDEWEB)
New techniques were developed to construct Schottky barrier and homojunction solar cells on GaAs substrates. Schottky barrier metal-semiconductor solar cells were produced for the first time on p-type GaAs substrate using a sputter-deposition method to form the barrier. The sputter deposition of gold or gold/palladium is the key to the method since normal thermal evaporation of gold onto p-type GaAs produces ohmic contacts. The results of this investigation are consistent with the idea that sputter damage produces donor type surface states on GaAs. Barrier heights were measured for both p-type sputtered and n-type thermally evaporated diodes using current-voltage and capacitance-voltage methods. Deep-level transient spectroscopy was used to identify the trap center concentration and energy levels for both diodes in an effort to explain the relatively large dark current in the p-type sputtered diodes. Homojunction GaAs solar cells were fabricated using several ...
1983-01-01
Energy Technology Data Exchange (ETDEWEB)
After the transcription of the electricity directive in national legislations, the European electricity market appears to be a vast set of juxtaposed markets which are weakly connected at the level of their wholesale contracts compartment. Referring to the technological peculiarities of electricity as a commodity, the paper identifies the direct conditions of regional integration of the electricity markets, those which would favour cross-border trade and allow to be near the normal functioning of a regional commodity market. The infrastructure network dependence and the need of a stringent technical coordination necessitate to unify the operation of the different systems and the rules of access, or at the least to come near this unification by strong coordination. A second major condition, which is not fully debated, is the increasing connexion of short-term markets, via daily physical trade and emergence of a European financial market, which ...
2000-11-01
Energy Technology Data Exchange (ETDEWEB)
Formaldehyde, a well-identified indoor pollutant, was recently classified as carcinogenic. New regulations for the air quality are expected and therefore there is a need for low-cost sensors, sensitive and selective with a fast response time for the detection of formaldehyde at ppb level. In the present work, we had developed a chemical sensor based on nano-porous matrices doped with Fluoral-P and optical methods of detection. The nano-porous matrices, elaborated via the Sol-Gel process, display nano-pores whose cavity is tailored for the trapping of the targeted pollutant. They provide a first selectivity with the discrimination of the pollutants by their size. A second selectivity is obtained with a molecular probe, Fluoral-P, which reacts specifically with formaldehyde leading to the 3,5- di-acetyl-1,4-dihydro-lutidine (DDL). The kinetics of formation of DDL was studied as function of many parameters such as the concentration of Fluoral-P in ...
2006-12-15
On the properties of plasma crystals
Energy Technology Data Exchange (ETDEWEB)
When a plasma becomes contaminated by foreign particles, generically referred to as dust, the result is called a dusty plasma. At the present time there is a great deal of interest in dusty plasmas because of their roles in terrestrial and extra-terrestrial processes - semiconductor processing, high temperature fusion experiments, stellar formation and the rings of Saturn. This thesis is concerned with the role of dust in processing type plasmas. In the following experiments, artificial dust is introduced into a parallel electrode plasma chamber. Ions and electrons in the plasma charge the dust particles and they become suspended in the plasma due to the balancing of electric and gravitational forces. By illuminating the suspended dust with laser light and using an extremely high speed camera fitted with a macro lens to look at the scattered light, the dust particles are observed directly. Specially written computer software is then able to track and analyse the particles' ...
1999-07-01
In this paper we review and classify the various patterns of isosteric heat versus loading for adsorption of gases on graphitised thermal carbon black at temperatures ranging from below the 3D triple point to temperatures above it, but less than the 3D critical point. We have identified the features of heat curve and highlighted the microscopic origin of these features. The patterns vary with temperature and with the relative strength of the fluid-fluid interaction and solid-fluid interaction. For simple adsorptives (by simple we meant there is no strong association between fluid particles), the heat curve is typified by fluid-fluid attraction and layering phenomena. For adsorptives showing strong association such as water, ammonia and methanol, the heat curve essentially begins below the condensation heat and then approaches it as loading is increased. This is mainly due to the strong hydrogen bonding in these fluids. A third group includes adsorptives such as ...
2008-05-24
We model nongraphitized carbon black surfaces and investigate adsorption of argon on these surfaces by using the grand canonical Monte Carlo simulation. In this model, the nongraphitized surface is modeled as a stack of graphene layers with some carbon atoms of the top graphene layer being randomly removed. The percentage of the surface carbon atoms being removed and the effective size of the defect (created by the removal) are the key parameters to characterize the nongraphitized surface. The patterns of adsorption isotherm and isosteric heat are particularly studied, as a function of these surface parameters as well as pressure and temperature. It is shown that the adsorption isotherm shows a steplike behavior on a perfect graphite surface and becomes smoother on nongraphitized surfaces. Regarding the isosteric heat versus loading, we observe for the case of graphitized thermal carbon black the increase of heat in the submonolayer coverage and then a sharp ...
2006-09-01
Energy Technology Data Exchange (ETDEWEB)
A study has been made of the reaction [sup 86]Kr + [sup 63]Cu at incident energies of 486, 550, 640, and 730 MeV. Measurements include cross sections, angular distributions, and energy spectra for light charged particles ([sup 1,2,3]H and [sup 4]He), intermediate mass fragments (IMF) (4 [le] Z [le] 17), and heavy fragments (Z [ge] 18). Coincidences between light charged particles and between particles and fragments have been measured to obtain cross sections, energy spectra, and angular distributions. Statistical model analysis of the energy spectra for [sup 1]H and [sup 4]He detected in coincidence with the fragments has allowed estimation of [sup 1]H and [sup 4]He multiplicities associated with the evaporation residues, fragments, and composite nuclei prior to scission. A comparison of cross sections, energy spectra, angular distributions, and particle multiplicities for these matched entrance channels has provided the means for a detailed test of the Bohr Independence Hypothesis. ...
1992-01-01
Kinetic and mechanistic studies of the reactions of CF{sub 3}O radicals with NO and NO{sub 2}
Energy Technology Data Exchange (ETDEWEB)
The reactions of CF{sub 3}O radicals with (1) NO and (2) NO{sub 2} were studied using two different experimental techniques. A laser photolysis/LIF detection method was applied for measuring the rate constants as a function of temperature (T=222-302 K) and total pressure (p{sub tot}=7-107 mbar). Whereas the reaction with (1) NO was found to be independent of temperature and pressure with k{sub 1}=(4.5{+-}1.2) x 10{sup -11} cm{sup 3}s{sup -1}, the reaction with (2) NO{sub 2} was found to be dependent on both of these variables. The temperature dependence of k{sub 2} in the high pressure limit can be given by the expression k{sub 2{infinity}}{sup -}(T)=(8{+-}5) x 10{sup -13} exp ((863{+-}194) K/T) cm{sup 3}s{sup -1}. The product distributions of the two reactions were determined in separate experiments using steady-state photolysis combined with FTIR spectroscopy. For reaction (1) only CF{sub 2}O was found as a reaction product with a yield of 0.93{+-}0.10, ...
1997-10-01
Adolescent exposure to anabolic androgenic steroids (AAS) alters the development and activity of the glutamate neural system in the latero-anterior hypothalamus (LAH) in hamsters (Mesocricetus auratus); that is, an important neural component of the adolescent AAS-induced aggressive response. In this article, we used retrograde tracing to investigate glutamate-specific alterations in the connections between the LAH and several other nuclei implicated in adolescent AAS-induced aggression. Briefly, hamsters were treated with AAS or sesame-oil control during adolescence and then microinjected with retrograde tracer into the medial amygdala (MeA), lateral septum (LS), or bed nucleus of the stria terminalis (BNST). Brains were then processed for vesicular glutamate transporter 2 (VGLUT2) and examined for AAS-induced changes in the number VGLUT2 cells containing retrograde tracer (VGLUT2/tracer) within the LAH. It is interesting to note that while aggressive AAS-treated hamsters injected ...
2011-08-22
Gene Repressive Activity of RIP140 Through Direct Interaction with CDK8.
Receptor interacting protein 140 (RIP140) is a coregulator for numerous nuclear receptors and transcription factors and primarily exerts gene-repressive activities on various target genes. We previously identified a spectrum of posttranslational modifications on RIP140 that augment its property and biological activity. In T(3)-triggered biphasic regulation of cellular retinoic acid binding protein 1 (Crabp1) gene along the course of fibroblast-adipocyte differentiation, we found TRAP220(MED1) critical for T(3)-activated chromatin remodeling whereas RIP140 essential for T(3)-repressive chromatin remodeling of this gene promoter. In this current study, we aim to examine whether and how RIP140 replaces TRAP220(MED1) on the CrabpI promoter in differentiating adipocyte cultures. We find increasing recruitment of RIP140 to this promoter, with corresponding reduction in TRAP220(MED1) recruitment during the T(3)-repressive phase. We also uncover direct interaction of ...
2011-08-25
This paper summarizes results of preliminary experiments to develop cytological and biochemical indicators for estimating damage to respiratory cells in test animals exposed by inhalation to toxic agents associated with nonnuclear energy production, the specific goal being the application of advanced multiparameter flow-systems technologies to the detection of early atypical cellular changes in lung epithelium. Normal Syrian hamster lung cell samples composed of histiocytes, leukocytes, macrophages, ciliated columnar cells, and epithelial cells were stained with fluorescent dyes specific for different biochemical parameters and were analyzed in liquid suspension as they flowed through a chamber intersecting a laser beam of exciting light. Multiple sensors measured the total or two-color fluorescence and light scatter on a cell-by-cell basis. Cellular parameters proportional to optical measurements (i.e., cell size, DNA content, total protein, nonspecific esterase activity, nuclear and ...
1976-01-01
A marine propulsion system is a very complicated system composed of many mechanical components. As a result, the vibration signal of a gearbox in the system is strongly coupled with the vibration signatures of other components including a diesel engine and main shaft. It is therefore imperative to assess the coupling effect on diagnostic reliability in the process of gear fault diagnosis. For this reason, a fault detection and diagnosis method based on bispectrum analysis and artificial neural networks (ANNs) was proposed for the gearbox with consideration given to the impact of the other components in marine propulsion systems. To monitor the gear conditions, the bispectrum analysis was first employed to detect gear faults. The amplitude-frequency plots containing gear characteristic signals were then attained based on the bispectrum technique, which could be regarded as an index actualizing forepart gear faults diagnosis. Both the back propagation neural network (BPNN) and the ...
2011-03-01
Expert-systems application to power network security analysis
Energy Technology Data Exchange (ETDEWEB)
In abnormal conditions, the operator's ability to deal with a large volume of data, and initiate the most appropriate remedial action is a fundamental concern in the design of energy control centers. Once a severe disruption has occurred in the power network, a series of tasks are required before the operator can make any decisions. Many of these functions involve computational efforts, and require a long period of processing time. The application of a wrong set of information by the operator may result in a catastrophic recovery situation. Also, as the system becomes larger, the required time for these tasks grows significantly and the operator may have very little time to analyze the contingency and issue a proper decision. These facts have led to the conclusion that a computer driven decision making mechanism will help the operator perform duties with minimum flaws and maximum efficiency. The challenge in applying an expert system to a power network is ...
1989-01-01
Effect of mating surface on the high temperature wear of 253 MA alloy
Energy Technology Data Exchange (ETDEWEB)
The wear behaviour of metallic material is influenced by the friction force, which in turn, is governed by the hardness and oxidation kinetics of the mating surface. In view of this, present investigation is undertaken to find the influence of mating surface on the high temperature wear of 253 MA alloy. This alloy is developed for high temperature application. In this work 253 MA alloy is made to slide against two different types of counter face material, namely 100Cr6 steel and PM 1000 alloy, at five different temperatures. 100Cr6 steel gets soften with increase of temperature whereas PM 1000 alloy retains its strength even at high temperature. The friction coefficient and the thickness loss of 253 MA alloy is measured and compared against both variety of mating surfaces as function of temperatures. The morphology of the worn surfaces and the transverse section of the worn surfaces are examined under scanning electron microscope (SEM) to ...
2004-04-01
Energy Technology Data Exchange (ETDEWEB)
The Alloy 800 tubes used in CANDU 6 steam generators have not experienced significant corrosion damage to date, which may be attributed to successful water chemistry control strategies. However, it is known that Alloy 800, like other steam generator (SG) tubing materials, is not immune to corrosion, especially pitting, under some plausible but off-specification operating scenarios. Electrochemical measurements provide information on corrosion susceptibility and rate, which are known to be a function of water chemistry. Using laboratory data in combination with chemistry monitoring and diagnostic software it is possible to assess the impact of plant operating conditions on SG tube corrosion for plant life management (PLIM). In this context, this paper discusses the results of electrochemical measurements made to elucidate the corrosion behaviour of Alloy 800 SG tubes under conditions simulating those plausible in SG crevices. In addition to crevice pH, the influence ...
2001-09-01
Development of engineering parameters for the design of metal biosorption waste treatment systems
Energy Technology Data Exchange (ETDEWEB)
Untreated landfill leachates and wastes from metal plating and mining operations are sources of environmental contamination by heavy metals. Because of their toxicity and potential for accumulation, the discharge of heavy metals must be controlled. Standard physical and chemical treatments used to remove metals from wastes such as concentration by electro-precipitation, ion exchange, solvent extraction, evaporative recovery, and conventional precipitation, are usually expensive and produce high quantities of sludge. Biosorption is the removal of metals from aqueous solutions by microorganisms. It is called biosorption rather than bioadsorption or bioaccumulation because the mechanisms of removal are not restricted to adsorption or metabolic uptake and so the more general term is preferable and has come to be accepted. In this thesis the focus is one two microorganisms and two metals. However, the possible combinations of conditions such as pH, relative metal molarities, time of ...
1991-12-03
Development of an assay for a biomarker of pregnancy and early fetal loss
Energy Technology Data Exchange (ETDEWEB)
Human chorionic gonadotropin (hCG) is a glycoprotein hormone, secreted by the syncytiotrophoblast cells of the fertilized ovum, that enters the maternal circulation at the time of endometrial implantation. It is composed of two nonidentical subunits; ..cap alpha.. and ..beta.., with molecular weights of 14 kD and 23 kD, respectively. Human chorionic gonadotropin binds to the same receptor as hLH and displays the same biological response, namely, to stimulate the declining function of the corpus luteum to produce progestins and estrogen late in the menstrual cycle. The differences in the structures of hCG and hLH have been exploited to develop antibodies that can measure hCG specifically in the presence of hLH. Two-site antibody binding assays have been developed, based on a surface immunological concept of hCG epitopes, that involve four distinct regions to which antibodies against hCG can bind simultaneously. Antibody cooperative effects, in conjunction with ...
1987-10-01
The petroleum industry is increasing its focus on the exploration of reservoirs in turbidite systems. However, these sedimentary environments are often characterized by very complex sand distributions. Hence, reservoir description based on conventional seismic and well-log interpretation may be very uncertain. There is a need to employ more quantitative seismic techniques to reveal reservoirs units in these complex systems from seismic amplitude data. In this study we focus on North Sea turbidite systems. Our goal is to improve the ability to use 3D seismic data to map reservoirs in these systems. A cross-disciplinary methodology for seismic reservoir characterization is presented that combines rock physics, sedimentology, and statistical techniques. We apply this methodology to two turbidite systems of Paleocene age located in the South Viking Graben of the North Sea. First, we investigate the relationship between sedimentary petrography and rock physics properties. Next, we define ...
2000-01-01
International Nuclear Information System (INIS)
A rat thyrotropin (thyroid-stimulating hormone, TSH) receptor cDNA was isolated that encoded a protein of 764 amino acids, M_r 86,528. Transfection of the cDNA caused COS-7 cells to develop a TSH-sensitive adenylate cyclase response and the ability to bind "1"2"5I-labeled TSH; both activities were similar to those of rat FRTL-5 thyroid cells and not duplicated by lutropin. The gene represented by the cDNA was assigned to mouse chromosome 12 and human chromosome 14. Northern analyses identified two species of mRNA, 5.6 and 3.3 kilobases, in FRTL-5 thyroid cells; the transcripts appeared to differ only in the extent of their 3' noncoding sequences. There were minimal amounts of the two mRNAs in rat ovary, and neither was detected in RNA preparations from rat testis, liver, lung, brain, spleen, and FRT thyroid cells, which do not have a functional TSH receptor. TSH decreased both mRNA species 3- to 4-fold within 8 hr in FRTL-5 thyroid cells; ...
1990-01-01
International Nuclear Information System (INIS)
A unique feature of cyanobacteria genomes is the abundance of genes that code for hypothetical proteins containing tandem pentapeptide repeats approximately described by the consensus motif A(N/D)LXX. To date, the structures of two pentapeptide-repeat proteins (PRPs) have been determined, with the tandem pentapeptide-repeat sequences observed to adopt a novel type of right-handed quadrilateral ?-helix, or Rfr-fold, in both structures. One structure, Mycobacterium tuberculosis MfpA, is a 183-residue protein that contains 30 consecutive pentapeptide repeats and appears to offer antibiotic resistance by acting as a DNA mimic. The other structure, Cyanothece 51142 Rfr32, is a 167-residue protein that contains 21 consecutive pentapeptide repeats. The function of Rfr32, like the other 35 hypothetical PRPs identified in the genome of Cyanothece, is unknown. In an effort to understand the role of PRPs in cyanobacteria and to better characterize the ...
2006-01-01
Energy Technology Data Exchange (ETDEWEB)
The significant and rapid reduction of greenhouse gas emissions is recognized as necessary to mitigate the potential climate effects from global warming. The postcombustion capture (PCC) and storage of carbon dioxide (CO{sub 2}) produced from the use of fossil fuels for electricity generation is a key technology needed to achieve these reductions. The most mature technology for CO{sub 2} capture is reversible chemical absorption into an aqueous amine solution. In this study the results from measurements of the CO{sub 2} absorption capacity of aqueous amine solutions for 76 different amines are presented. Measurements were made using both a novel isothermal gravimetric analysis (IGA) method and a traditional absorption apparatus. Seven amines, consisting of one primary, three secondary, and three tertiary amines, were identified as exhibiting outstanding absorption capacities. Most have a number of structural features in common including steric hindrance and ...
2009-08-15
Energy Technology Data Exchange (ETDEWEB)
The large aggregating proteoglycan aggrecan is a major structural component of the extracellular matrix of articular cartilage. Recent cDNA cloning of the human aggrecan gene (AGC1) reveals a core protein of at least 2316 amino acids characterized by several distinct structural domains. Two globular domains, termed G1 and G2, are present at the amino terminus of the molecule and a third, termed G3, is present at the carboxy terminus. The G1 domain is homologous in structure to the cartilage link protein and accounts for the aggregating potential of aggrecan through its ability to interact with hyaluronic acid. The aggrecan gene is known to consist of 15 exons, with each exon encoding a distinct functional region of the mature protein. However, while the link protein gene is known to reside on chromosome 5 in the human, the location of the aggrecan gene is currently undetermined in any species. The probe (pAGG2) for the aggrecan gene was mapped on chromosome band ...
1993-05-01
An Arabidopsis thaliana methyltransferase Capable of Methylating Farnesoic Acid
Energy Technology Data Exchange (ETDEWEB)
We previously reported the identification of a new family of plant methyltransferases (MTs), named the SABATH family, that use S-adenosyl-l-methionine (SAM) to methylate a carboxyl moiety or a nitrogen-containing functional group on a diverse array of plant compounds. The Arabidopsis genome alone contains 24 distinct SABATH genes. To identify the catalytic specificities of members of this protein family in Arabidopsis, we screened recombinantly expressed and purified enzymes with a large number of potential substrates. Here, we report that the Arabidopsis thaliana gene At3g44860 encodes a protein with high catalytic specificity towards farnesoic acid (FA). Under steady-state conditions, this farnesoic acid carboxyl methyltransferase (FAMT) exhibits K{sub M} values of 41 and 71 {mu}M for FA and SAM, respectively. A three-dimensional model of FAMT constructed based upon similarity to the experimentally determined structure of Clarkia breweri ...
2006-01-01
In vertebrates, the positioning of the internal organs relative to the midline is asymmetric and evolutionarily conserved. A number of molecules have been shown to play critical roles in left-right patterning. Using representational difference analysis to identify genes that are differentially expressed on the left and right sides of the chick embryo, we cloned chick Claudin-1, an integral component of epithelial tight junctions. Here, we demonstrate that retroviral overexpression of Claudin-1, but not Claudin-3, on the right side of the chick embryo between HH stages 4 and 7 randomizes the direction of heart looping. This effect was not observed when Claudin-1 was overexpressed on the left side of the embryo. A small, but reproducible, induction of Nodal expression in the perinodal region on the right side of the embryo was noted in embryos that were injected with Claudin-1 retroviral particles on their right sides. However, no changes in Lefty,Pitx2 or cSnR ...
2006-02-24
Energy Technology Data Exchange (ETDEWEB)
ATR-X (alpha-thalassemia/mental retardation, X-linked) syndrome is a human congenital disorder that causes severe intellectual disabilities. Mutations in the ATRX gene, which encodes an ATP-dependent chromatin-remodeler, are responsible for the syndrome. Approximately 50% of the missense mutations in affected persons are clustered in a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, ADD{sub ATRX}), whose function has remained elusive. Here we identify ADD{sub ATRX} as a previously unknown histone H3-binding module, whose binding is promoted by lysine 9 trimethylation (H3K9me3) but inhibited by lysine 4 trimethylation (H3K4me3). The cocrystal structure of ADD{sub ATRX} bound to H3{sub 1-15}K9me3 peptide reveals an atypical composite H3K9me3-binding pocket, which is distinct from the conventional trimethyllysine-binding aromatic cage. Notably, H3K9me3-pocket mutants and ATR-X syndrome mutants are defective in both H3K9me3 binding and ...
2011-07-19
ALASKA OIL AND GAS EXPLORATION, DEVELOPMENT, AND PERMITTING PROJECT
Energy Technology Data Exchange (ETDEWEB)
This is the second technical report, covering the period from April 1, 2003 through September 30, 2003. This project brings together three parts of the oil exploration, development, and permitting process to form the foundation for a more fully integrated information technology infrastructure for the State of Alaska. The geo-technical component is a shared effort between the State Department of Administration and the US Department of Energy. The Alaska Oil and Gas Conservation Commission is rapidly converting high volumes of paper documents and geo-technical information to formats suitable for search and retrieval over the Internet. The permitting component is under the lead of the DNR Office of Project Management and Permitting. A web-based system will enable the public and other review participants to track permit status, submit and view comments, and obtain important project information on-line. By automating several functions of the current manual process, ...
2003-11-19
A Preliminary Study for the Analysis of PSA Success Criteria for Kori Units 3 and 4
Energy Technology Data Exchange (ETDEWEB)
This paper identifies the event sequences that require thermal-hydraulic analyses for the success criteria of probabilistic safety analysis (PSA). The selection of the sequences is performed based on the review of the NEI Peer Review Process Guidance and ASME PRA Standard. Success criteria are the important element of PSA quality. Success criteria decide the success or failure of the key function in the PSA event tree. It is defined as a minimum set of components/trains of system required to mitigate an accident. Thermal-hydraulic codes are generally used to derive time-related criteria in the PSA, such as operator action time used in human reliability analysis (HRA), event timing, and time to recover the component or the power. This paper suggests the use of the MARS code for the T-H analysis to obtain the success criteria and sequence timing, and operator action time. In the Kori Units 3 and 4 PSA report, the T-H analyses for those criteria ...
2009-10-15
A Preliminary Study for the Analysis of PSA Success Criteria for Kori Units 3 and 4
International Nuclear Information System (INIS)
This paper identifies the event sequences that require thermal-hydraulic analyses for the success criteria of probabilistic safety analysis (PSA). The selection of the sequences is performed based on the review of the NEI Peer Review Process Guidance and ASME PRA Standard. Success criteria are the important element of PSA quality. Success criteria decide the success or failure of the key function in the PSA event tree. It is defined as a minimum set of components/trains of system required to mitigate an accident. Thermal-hydraulic codes are generally used to derive time-related criteria in the PSA, such as operator action time used in human reliability analysis (HRA), event timing, and time to recover the component or the power. This paper suggests the use of the MARS code for the T-H analysis to obtain the success criteria and sequence timing, and operator action time. In the Kori Units 3 and 4 PSA report, the T-H analyses for those criteria ...
2009-10-01
UK PubMed Central (United Kingdom)
Previous studies have been conducted in gene expression profiling to identify groups of genes that characterize the colorectal carcinoma disease. Despite the success of previous attempts to identify...Full Text Available
Multilevel support vector regression analysis to identify condition-specific regulatory networks
UK PubMed Central (United Kingdom)
Motivation: The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify...Full Text Available
2010-06-01
Light duty utility arm startup plan
Energy Technology Data Exchange (ETDEWEB)
This plan details the methods and procedures necessary to ensure a safe transition in the operation of the Light Duty Utility Arm (LDUA) System. The steps identified here outline the work scope and identify responsibilities to complete startup, and turnover of the LDUA to Characterization Project Operations (CPO).
1998-09-01
Large-scale cross-species oncogenomics identifies candidate oncogenes and tumor suppressor genes
UK PubMed Central (United Kingdom)
While genomic alterations identified in human tumors using techniques such as comparative genomic hybridisation (CGH) may be recurrent, they frequently encompass large regions, in some cases...Full Text Available
2010-02-01
Energy Technology Data Exchange (ETDEWEB)
The development of a computational intelligent tools based on neural network to identify commercial losses or fraud (theft energy), considering information from a database electric utility, is presented.
2009-07-01
How and when can one identify hadronic molecules in the baryon spectrum
Energy Technology Data Exchange (ETDEWEB)
A method to identify hadronic molecules in the particle spectrum is reviewed and the conditions for its applicability discussed. Special emphasis is put on the discussion of molecule candidates in the baryon spectrum. (orig.)
2008-03-15
UK PubMed Central (United Kingdom)
Descriptive assessment methods have been used in applied settings to identify consequences for problem behavior, thereby aiding in the design of effective treatment programs. Consensus has not been...Full Text Available
2008-01-01
A DNA transposon-based approach to validate oncogenic mutations in the mouse
UK PubMed Central (United Kingdom)
Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available
2008-12-16
...dates of the implementation of the standard unique health identifier for health care providers. 162.404 Section 162.404 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA...
2010-10-01
Aging of Pentaerythritol Tetranitrate (PETN)
Pentaerythritol tetranitrate (PETN) is a relatively sensitive explosive used in many electroexplosive devices as well as in medicine. Of primary interest to LLNL is its use in items such as exploding bridgewire (EBW) detonators and exploding bridge foil initiators (EFI). In these devices the crystalline powder is pressed into a granular, low-density compact that can be initiated by an exploding wire or foil. The long-term stability of this pressed compact is of interest to weapon stockpile lifetime prediction studies. Key points about potential aging mechanisms can be summarized as follows: (1) There are a number of factors that can contribute to PETN instability. These include particle size, polymorphic phase transitions, crystal structure, impurities, moisture, occlusions, chemical incompatibility and biological (microorganism) action. of these factors the most important for long-term aging of high surface area powders used in detonators appears to be that of particle size growth. ...
2009-04-22
The DIVAD Archaeological Project
... Like other surveys in the Hueco Bolson (Carmichael 1983; Whalen 1977, 1978), the BLM survey identified large concentrations of Pueblo period ...
2011-05-14
DIGITAL LIBRARIES: IMPACT ON SCIENCE ... - MUSPIN - NASA
digital libraries, which was identified as a national challenge in the Information ... The linkages between the many digital libraries and information services are ...
... reverse aeb 9 nescesmsy amI identify by block number) Provides procedures for evaluating metal, consumable, and combustible cartridge cases. ...
1980-10-21
Aviation Maintenance Safety Articles, January/February 1990
... These are abnormal and an indication of NAVAIRINST 13340.3 identifies these laboratories a possible breakdown in the fuel-handling equip- ...
1990-02-01
Atomic density functions: atomic physics calculations analyzed with methods from quantum chemistry
This contribution reviews a selection of findings on atomic density functions and discusses ways for reading chemical information from them. First an expression for the density function for atoms in the multi-configuration Hartree--Fock scheme is established. The spherical harmonic content of the density function and ways to restore the spherical symmetry in a general open-shell case are treated. The evaluation of the density function is illustrated in a few examples. In the second part of the paper, atomic density functions are analyzed using quantum similarity measures. The comparison of atomic density functions is shown to be useful to obtain physical and chemical information. Finally, concepts from information theory are introduced and adopted for the comparison of density functions. In particular, based on the Kullback--Leibler form, a ...
2011-01-01
Industrial waste and pollution in Mongolia
Energy Technology Data Exchange (ETDEWEB)
This paper very briefly outlines hazardous waste management issues, including regulations, in Mongolia. Air, water, and soil pollutants are identified and placed in context with climatic, social, and economic circumstances. The primary need identified is technology for the collection and disposal of solid wastes. Municipal waste problems include rapid urbanization and lack of sanitary landfills. Industrial wastes of concern are identified from the mining and leather industries. 4 refs., 2 tabs.
1996-12-31
The closure operator in a multivalued logic based on functional equations
British Library Electronic Table of Contents (United Kingdom)
An operator of FE-closure is introduced on the set of functions of a multivalued logic based on the systems of functional equations. It is proved that, for every k ? 2, the FE-closure operator generates a finite classification on the set P k of functions of k-valued logic. The least class in this classification is shown to be the class H k of all homogeneous functions. Also a series of corollaries are obtained concerning the finite FE-generating sets in the FE-closed classes.
2011-01-01
Finding the best quadratic approximation of a function
British Library Electronic Table of Contents (United Kingdom)
This article examines the question of finding the best quadratic function to approximate a given function on an interval. The prototypical function considered is f(x) = ex. Two approaches are considered, one based on Taylor polynomial approximations at various points in the interval under consideration, the other based on the fact that three non-collinear points determine a unique quadratic function. Three different techniques for measuring the error in the approximations are considered.
2011-01-01
Studies of basic parameters of electron-counting detection
International Nuclear Information System (INIS)
Measurements have been made of certain parameters relevant to the operation of electron-counting detectors. An experimental chamber consisting of a uniform-field drift tube and a coaxial proportional counter thas been employed to obtain data, at very low drift fields (E/p<0.02 V/cm Torr), on electron mobility and lifetimes in a range of gas mixtures. These mixtures included argon, methane, nitrogen and carbon dioxide. Measurements of single-electron spectra showed that, unexpectedly for the standard gas mixtures employed, useful departure from an exponential spectrum was not possible without the production of cathode secondaries. Although the present studies employed only the counter electrical signal the information obtained should be directly relevant to the operation of practical light-pulse systems. Examples of electron-counting spectra for soft X-rays are shown. (orig.).
1990-05-21
British Library Electronic Table of Contents (United Kingdom)
The relevance of the mean retention time (MRT) of particles through the gastrointestinal tract (GIT) is well understood and MRTparticleGIT is an important parameter in digestion models. Solute markers have been used to estimate MRTsoluteGIT (or 'fluid passage') in animals, but the relevance of this measure is less evident and is usually sought in its relation to MRTparticleGIT. The ratio between the two measures indicates the degree of 'digesta washing', with little washing occurring at ratios of 1, aborad washing at ratios >1 (where the solute marker travels faster than the particle marker), and orad (retrograde) washing at ratios <1 (where the solute marker travels slower than the particle marker). We analysed digesta washing in a dataset of 98 mammalian species including man of differen...
2011-01-01
Multiple treatment comparison meta-analyses: a step forward into complexity
The use of meta-analysis has become increasingly useful for clinical and policy decision making. A recent development in meta-analysis, multiple treatment comparison (MTC) meta-analysis, provides inferences on the comparative effectiveness of interventions that may have never been directly evaluated in clinical trials. This new approach may be confusing for clinicians and methodologists and raises specific challenges relevant to certain areas of medicine. This article addresses the methodological concepts of MTC meta-analysis, including issues of heterogeneity, choice of model, and adequacy of sample sizes. We address domain-specific challenges relevant to disciplines of medicine, including baseline risks of patient populations. We conclude that MTC meta-analysis is a useful tool in the context of comparative effectiveness and requires further study, as its utility and transparency will likely predict its uptake by the research and clinical ...
2011-05-27
Integrated knowledge management in networks; Integriertes Wissensmanagement in Netzwerken
Energy Technology Data Exchange (ETDEWEB)
Knowledge is a success factor for globally acting company networks as a. o. the aim-oriented knowledge transfer between partners is an essential condition for a successful cooperation. Several network specific problems impede however an efficient and effective knowledge management; e.g. the transfer of competition relevant data is a high sensitive theme. The authors describe how a relevant method can be selected, adapted and implemented to the application-specific boundary conditions. They integrate existing attempts processes and methods to establish an effective knowledge development and an efficient knowledge transfer in the network and take into account ''hard'' (IT-technical-oriented solution approaches) as also ''soft'' factors (e.g. cultural and personal aspects). So the authors present unified instruments for an integrated knowledge management in networks. (GL)
2007-07-01
Energy Technology Data Exchange (ETDEWEB)
The present work focuses on investigations of a highly selective ligand for Am(III)/Ln(III) separation: bis-triazinyl-pyridine (BTP). By means of nano-electro-spray mass spectrometry, complex formation of BTP with selected elements of the lanthanide series is investigated. We show that the diluent drastically influences complex speciation. Measurements obtained in the extraction-relevant diluent 1-octanol show the occurrence of Ln(BTP){sub i} (i 1-3) species in different relative abundances, depending on the lanthanide used. Here, the relative abundances of the Ln(BTP){sub 3} complexes correlate with the distribution ratios for extraction to the organic phase of the respective lanthanide. (authors)
2009-12-15
Energy Technology Data Exchange (ETDEWEB)
In the geologic formation where the oil deposits are located, diverse types of rocks perform functions as structural elements, storage containers for hydrocarbon water and calorific energy, as well as impermeable barriers and transport means of the energy and the fluids. Among the most important properties that are used to describe these functions are the porosity, the permeability, the compressibility of the pores volume, the formation resistivity factor, the saturation exponent, the velocity of acoustic waves P and S, the relative permeability, the capillary pressures, the elastic constants and other mechanical properties, the thermal expansion, coefficient, the thermal conductivity, the thermal diffusivity and the specific heat. The execution of an ample variety of activities related to the stages of exploration, location, evaluation and development of the oil deposits, depends strongly on having a good knowledge of the magnitude and the ...
2007-07-01
Structure functions of nuclei in fluctonic model with rescaling
International Nuclear Information System (INIS)
It is shown that the available data on x, Q"2, and A dependence of nuclear structure functions and for their ratios (EMS effect) can be described in terms of the flucton model with rescaling of parton distributions in nuclei. The x, Q"2 and A dependence of nuclear structure functions in the cumulative range (x >1) is predicted.
Pulmonary Function and the Risk of Functional Limitation in Chronic Obstructive Pulmonary Disease
UK PubMed Central (United Kingdom)
The authors’ objective was to analyze the impact of respiratory impairment on the risk of physical functional limitations among adults with chronic obstructive pulmonary disease (COPD)....Full Text Available
2008-05-01
On the construction of approximations to continuous functions under integral boundary conditions
British Library Electronic Table of Contents (United Kingdom)
On the basis of the resolvent of a simple differential operator, a method for finding approximations to continuous functions is constructed. In this method, both the approximated function and its approximations satisfy the given integral boundary condition.
2011-01-01
Increased wind-up to heat pain in women with a childhood history of functional abdominal pain
UK PubMed Central (United Kingdom)
Idiopathic or functional abdominal pain (FAP) is common in school-age children and typically reflects a functional gastrointestinal disorder (FGID). FGIDs in adults have been distinguished by...Full Text Available
2011-04-01
UK PubMed Central (United Kingdom)
The functional gene and three intronless pseudogenes for human triosephosphate isomerase were isolated from a recombinant DNA library and characterized in detail. The functional gene spans 3.5 kilobase...Full Text Available
1985-07-01
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