identifies cyclin b1: Topics by WorldWideScience.org

Characterization of a Novel Small Molecule Subtype Specific Estrogen-Related Receptor ? Antagonist in MCF-7 Breast Cancer Cells

Our studies have shown that endotoxin intratracheally instilled into the rat lung induces proliferation of alveolar type II cells. In that study, the alveolar type II cells. In that study, the alveolar type II cell hyperplasia occurred 2 d after instillation of endotoxin and persisted for a further 2 d. After hyperplasia, the lung remodeled and returned to a normal state within 24-48 h. Understanding the mechanisms involved in the remodeling process of this transient hyperplasia may be useful to identify molecular changes that are altered in neoplasia. The purpose of the present study was to corroborate induction of epithelial cell hyperplasia by endotoxin and to delineate mechanisms involved in tissue remodeling after endotoxin-induced alveolar type II cell hyperplasia. In conclusion, immonostaining with cyclin D1 and cytokeratin shows that endotoxin induced epithelial cell proliferation and resulted in hyperplasia in the lung which persisted ...

1995-12-01

2

Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts

BackgroundThe orphan nuclear receptor estrogen-related receptor b1; (ERRb1;) is a member of the nuclear receptor superfamily. It was identified through a search for genes...Full Text Available

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Roles for Rat Hepatocyte Malignant Transforming Factor (HMTF) in Late Stage of Hepatocarcinogenesis.

Cyclin-Dependent Kinase 1 (CDK1) is the major M-phase kinase known also as the M-phase Promoting Factor or MPF. Studies performed during the last decade have shown many details of how CDK1 is regulated...Full Text Available

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Enhanced MALDI-TOF MS Analysis of Phosphopeptides Using an Optimized DHAP/DAHC Matrix

In a previous study, to identify genes of importance for hepatocellular carcinogenesis, and especially for processes involved in malignant transformation, the authors investigated differences in gene expression between adenomas and carcinomas by DNA microarray. In the present study, the authors investigated AW434047, one of the sequences that was upregulated in carcinomas. The investigation led to the identification of a novel gene, which the authors named hepatocyte malignant transforming factor (HMTF), of unknown function whose expression was increased in hepatocellular carcinomas. Northern blot and in situ hybridization also demonstrated high levels of HMTF in rat hepatocellular carcinoma (HCC) cell lines, lymphocytes in the spleen, colon mucosal epithelia, spermatocytes, and granule cells of the hippocampus. Reduction of HMTF by RNA interference (RNAi) in N1 cells, an HCC cell line, caused suppression of cell proliferation, invasion, and migration. Suppression ...

2011-09-20

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The YTH Domain Is a Novel RNA Binding Domain*

Selecting an appropriate matrix solution is one of the most effective means of increasing the ionization efficiency of phosphopeptides in matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). In this study, we systematically assessed matrix combinations of 2, 6-dihydroxyacetophenone (DHAP) and diammonium hydrogen citrate (DAHC), and demonstrated that the low ratio DHAP/DAHC matrix was more effective in enhancing the ionization of phosphopeptides. Low femtomole level of phosphopeptides from the tryptic digests of ?-casein and ?-casein was readily detected by MALDI-TOF-MS in both positive and negative ion mode without desalination or phosphopeptide enrichment. Compared with the DHB/PA matrix, the optimized DHAP/DAHC matrix yielded superior sample homogeneity and higher phosphopeptide measurement sensitivity, particularly when multiple phosphorylated peptides were assessed. Finally, the DHAP/DAHC matrix was applied to identify ...

2010-01-01

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Characterization of a novel plasmid-like element in Neurospora crassa derived mostly from the mitochondrial DNA.

The YTH (YT521-B homology) domain was identified by sequence comparison and is found in 174 different proteins expressed in eukaryotes. It is characterized by 14 invariant residues within an b1;-helix/β-sheet...Full Text Available

2010-05-07

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Activation of Metallothioneins and ?-Crystallin/sHSPs in Human Lens Epithelial Cells by Specific Metals and the Metal Content of Aging Clear Human Lenses

We have identified a plasmid-like element within mitochondria of Neurospora crassa strain stp-B1. It is derived from the EcoRI-4 and EcoRI-6 regions of the mitochondrial DNA, and an additional 124 bp...Full Text Available

1990-10-11

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Atrazine exposure leads to altered growth of HepG2 cells

PurposeTo identify those metallothionein and b1;-crystallin/small heat-shock genes induced by toxic metals in human lens cells and to evaluate...Full Text Available

2003-02-01

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British Library Electronic Table of Contents (United Kingdom)

Atrazine is one of the most commonly used herbicides in the United States. While effective on target plants, it has been associated with harmful health effects in non-target organisms such as fish, amphibians and mammals. In this study, growth effects on human liver cells were determined after exposure to increasing concentrations of this herbicide. Growth of immortalized human hepatoma HepG2 cells was inhibited by atrazine concentrations of 625 ppb after 72 h exposure and flow cytometry analysis demonstrated HepG2 cells exposed to 100 ppb atrazine accumulated in S phase after 48 h compared to untreated cells. Expression of cell cycle specific cyclin proteins was altered after atrazine exposure with cyclin E levels significantly decreased after a 24 h exposure and cyclin B levels decreased...

2011-01-01

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The metabolism of the isomeric decalones

Gene Repressive Activity of RIP140 Through Direct Interaction with CDK8.

1. The metabolism of (�b1;)-cis-1-, (�b1;)-trans-1-, (�b1;)-cis-2- and (�b1;)-trans-2-decalone in the rabbit...Full Text Available

1966-08-01

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CYP1B1 mutations in Spanish patients with primary congenital glaucoma: phenotypic and functional variability

Receptor interacting protein 140 (RIP140) is a coregulator for numerous nuclear receptors and transcription factors and primarily exerts gene-repressive activities on various target genes. We previously identified a spectrum of posttranslational modifications on RIP140 that augment its property and biological activity. In T(3)-triggered biphasic regulation of cellular retinoic acid binding protein 1 (Crabp1) gene along the course of fibroblast-adipocyte differentiation, we found TRAP220(MED1) critical for T(3)-activated chromatin remodeling whereas RIP140 essential for T(3)-repressive chromatin remodeling of this gene promoter. In this current study, we aim to examine whether and how RIP140 replaces TRAP220(MED1) on the CrabpI promoter in differentiating adipocyte cultures. We find increasing recruitment of RIP140 to this promoter, with corresponding reduction in TRAP220(MED1) recruitment during the T(3)-repressive phase. We also uncover direct interaction of ...

2011-08-25

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Primitive hematopoietic cells resist HIV-1 infection via p21^{Waf1/Cip1/Sdi1}

PurposeTo analyze the contributions of cytochrome P4501B1 (CYP1B1) mutations to primary congenital glaucoma (PCG) in Spanish patients.MethodsWe...Full Text Available

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Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27^kip1in rats

Hematopoietic stem cells are resistant to HIV-1 infection. Here, we report a novel mechanism by which the cyclin-dependent kinase inhibitor (CKI) p21^{Waf1/Cip1/Sdi1} (p21), a known regulator...Full Text Available

2007-02-01

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Practical application of a simplified vitamin B_1_2 radioassay

BackgroundPulmonary vascular structure remodeling (PVSR) is a hallmark of pulmonary hypertension. P27^kip1, one of critical cyclin-dependent kinase inhibitors, has been...Full Text Available

2010-01-01

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Cyclin-Dependent Kinase Inhibitor p16 and p21 Expression, and Cell Cycle Change in Human Lens Epithelial Cell Line SRA 01/04 following Contact Inhibition in Normal Culture

... blood serum patients radioimmunoassay sampling tracer techniques isotope

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British Library Electronic Table of Contents (United Kingdom)

Abstract Purpose: To describe the pattern of expression of the cyclin-dependent kinase inhibitors (CDKIs) p16, p21 and p27, and the cell cycle in SRA 01/04 cells relative to contact inhibition. Methods: SRA 01/04 cells were grown to overconfluence under normal conditions. At various phases of the cell growth, cells were assayed by flow cytometry and Western blotting for the expression of CDKIs. Results: Expression of p16 was detected from early logarithmic growth to stationary phases, during which the number of cells in G0/G1 increased from 46 to 69%. Expression of p21 was detected only during the overgrowth phase, when 60% of the cells were in G0/G1. Expression of p27 was not observed in SRA 01/04 cells. Conclusions: p16 expression was likely mediated by G0/G1 arrest to induce contact inh...

2011-01-01

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5.6-nm p"+/n junction formation for sub-0.05-#mu#m PMOSFETs by using low-energy B_1_0H_1_4 ion implantation

Gel-based proteomics of liver cancer progression in rat.

Decaborane (B_1_0H_1_4) cluster ions were implanted into n-Si(100) substrates to fabricate shallow p"+/n junctions. Implant energies of 2 keV, 5 keV, and 20 keV, equivalent to implant energies of the monomer boron ion of 174 eV, 435 eV, and 1.74 keV, respectively, were used at dosages of 1 X 10"1"2 /cm"2 and 1 X 10"1"3 /cm"2. The implanted samples were then subjected to activation annealing at 800 .deg. C, 900 .deg. C, and 1000 .deg. C for 10 s. By using secondary ion mass spectrometry (SIMS) depth profiles, we determined that the depth of the shallow junction (D_s) at a dosage of 1 X 10"1"3 /cm"2 was in the range 12 nm - 45 nm after annealing at 1000 .deg. C. D_s and transient enhanced diffusion (TED) were greatly reduced at implant energies lower than 5 keV, but thermal diffusion (TD) smoothly decreased. In particular, TED was suppressed in the p"+/n junction implanted at 2 keV and a dosage of 1 X 10"1"3 /cm"2, and the formation of only a ...

2004-06-01

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The Caenorhabditis elegans Elongator Complex Regulates Neuronal ?-tubulin Acetylation

A significant challenge in proteomics biomarker research is to identify the changes that are of highest diagnostic interest, among the many unspecific aberrations associated with disease burden and inflammation. In the present study liver tissue specimens (n=18) from six experimental stages were collected from the resistant hepatocyte (RH) rat model of liver cancer and analyzed by 2D DIGE. The study included triplicates of regenerating liver, control "sham-operated" liver, three distinct premalignant stages and hepatomas. Out of 81 identified proteins two-thirds were differentially abundant in rat hepatomas compared to control rat liver and, secondly, the majority of proteins were also changed in precursor stages. This underscores the importance of adequate control samples in explorative cancer biomarker research. We confirm several proteomic changes previously identified in human hepatocellular carcinoma (HCC) and we ...

2011-06-06

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PYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells

Although acetylated b1;-tubulin is known to be a marker of stable microtubules in neurons, precise factors that regulate b1;-tubulin acetylation are, to date, largely unknown. Therefore,...Full Text Available

2010-01-01

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Distribution of ?-Galactosidase in Cucurbita pepo 1

BackgroundThe objective of this study was to gain insight into the molecular mechanism of induced cell death (apoptosis) by PYRROLO [1,2-b][1,2,5]BENZOTHIADIAZEPINES...Full Text Available

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Inactivation of aflatoxin B1 by using the synergistic effect of hydrogen peroxide and gamma radiation

The distribution of b1;-galactosidase (b1;-d-galactoside galactohydrolase [EC 3.2.1.22]) in Cucurbita pepo has been determined in an attempt to assess its involvement...Full Text Available

1978-11-01

22

miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NF?B1

Inactivation of aflatoxin B1 was studied by using gamma radiation and hydrogen peroxide. A 100-krad dose of gamma radiation was sufficient to inactivate 50 micrograms of aflatoxin B1 in the presence of 5% hydrogen peroxide, and 400 krad was required for total degradation of 100 micrograms of aflatoxin in the same system. Degradation of aflatoxin B1 was confirmed by high-pressure liquid chromatographic and thin-layer chromatographic analysis. Ames microsomal mutagenicity test showed loss of aflatoxin activity. This method of detoxification also reduces the toxin levels effectively in artificially contaminated groundnuts.

1989-02-01

23

Synergistic epigenetic reactivation of estrogen receptor-? (ER?) by combined green tea polyphenol and histone deacetylase inhibitor in ER?-negative breast cancer cells

The activation of nuclear factor-kappa B1 (NFκB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency of IR in lung cancer, we screened for...Full Text Available

2011-05-31

24

Phosphorylation of ?6-Tubulin by Protein Kinase C? Activates Motility of Human Breast Cells*

BackgroundThe status of estrogen receptor-b1; (ERb1;) is critical to the clinical prognosis and therapeutic approach in breast cancer. ERb1;-negative breast cancer...Full Text Available

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Ephrin B1 Regulates Bone Marrow Stromal Cell Differentiation and Bone Formation by Influencing TAZ Transactivation via Complex Formation with NHERF1?

Engineered overexpression of protein kinase Cb1; (PKCb1;) was previously shown to endow nonmotile MCF-10A human breast cells with aggressive motility. A traceable mutant of PKCb1;...Full Text Available

2009-06-26

26

Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates

Mutations of ephrin B1 in humans result in craniofrontonasal syndrome. Because little is known of the role and mechanism of action of ephrin B1 in bone, we examined the function of osteoblast-produced...Full Text Available

2010-02-01

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Covalent Modification of Thr302 in Cytochrome P450 2B1 by the Mechanism-Based Inactivator 4-tert-Butylphenylacetylene

Cytochrome P450 1B1 (Cyp1b1) metabolism contributes to physiological functions during embryogenesis, but also to carcinogenic activation of polycyclic aromatic hydrocarbons (PAH). We generated...Full Text Available

2008-09-15

28

Evidence for the h_b(1P) meson in the decay Upsilon(3S) --> pi0 h_b(1P)

The mechanism of inactivation of cytochrome P450 2B1 (CYP2B1) by 4-tert-butylphenylacetylene (BPA) has been characterized previously to be caused by the covalent binding of a reactive...Full Text Available

2010-06-01

29

Development of radioimmunometric assays and kits for non-clinical applications. Proceedings of a final research coordination meeting

Using a sample of 122 million Upsilon(3S) events recorded with the BaBar detector at the PEP-II asymmetric-energy e+e- collider at SLAC, we search for the h_b(1P) spin-singlet partner of the P-wave chi_b(1P) states in the sequential decay Upsilon(3S) --> pi0 h_b(1P), h_b(1P) --> gamma eta_b(1S). We observe an excess of events above background in the distribution of the recoil mass against the pi0 at mass 9902 +/- 4 (stat.) +/- 1 (syst.) MeV/c^2. The width of the observed signal is consistent with experimental resolution, and its significance is 3.0 sigma, including systematic uncertainties. We obtain the value (3.7 +/- 1.1 (stat.) +/- 0.7 (syst.))x 10^{-4} for the product branching fraction BF(Upsilon(3S) --> pi0 h_b) x BF(h_b --> gamma eta_b).

2011-01-01

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Disruption of contact inhibition in rat liver epithelial cells by various types of AhR ligands

Immunoassays are versatile analytical techniques that had a leading role in various clinical applications, during the last four decades. The studies carried out by Rosalyn Yalow, Solomon Berson and Roger Ekins in the 1960s gave a breakthrough in the development of this novel analytical method. Sensitivity up to femtomolar concentrations, high specificity and universal application to different classes of molecular species made immunoassay a very useful tool in analytical investigation. The expertise acquired by immunochemists in producing antibodies against any antigen and the ability of radiochemists in labeling the antigens with "1"2"5I without affecting the active site are the two main factors responsible for the above development. There are concerns about the safety and health of humans due to the high-level contamination of environment by pesticides, industrial compounds and metals, anabolic steroids in milk and meat products, and presence of mycotoxins in food and feed ...

2004-12-06

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Results from the photoemission spectroscopy beamline 2B1 at Pohang Light Source

The maintenance of a balance between cell gain and cell loss is essential for proper liver function. The exact role of aryl hydrocarbon receptor (AhR) in regulating cell proliferation and apoptosis of liver cells remains unclear, since ligand-dependent activation of AhR has been shown to induce cell cycle arrest, proliferation, differentiation or apoptosis, depending on the cellular model used. AhR can directly interact with retinoblastoma protein in hepatic cells, forming protein complexes that can efficiently block cell cycle progression by inducing G1 arrest, or to induce the expression of inhibitors of cyclin-dependent kinases, such as p271. On the other hand, it has been suggested that AhR could play a stimulatory role in cell proliferation, either directly or by mediating a release from contact inhibition. It is now generally accepted that progenitor cells exist in the liver, are activated in various liver diseases and can form a potential target cell ...

2004-09-15

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Phosphorylation of Annexin A1 by TRPM7 Kinase: A Switch Regulating the Induction of an ?-Helix

The results of photoemission spectroscopy using molybdenum and tantalum samples have been obtained from the new beamline 2B1 at Pohang Light Source. Beamline 2B1 is based on a spherical grating monochromator (SGM) which is equipped with five gratings. The photon energy range from 184 to 1100 eV was covered in this work using two gratings (Gratings 4 and 5). The photon energy resolution has been deduced from Ta Fermi-level spectra and 3d spectra of Mo.

1999-06-01

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A 12b 1kS/s 65uA 0.35um CMOS Algorithmic ADC for Sensor Interface in Ubiquitous Environments

TRPM7 is an unusual bifunctional protein consisting of an b1;-kinase...Full Text Available

2011-03-29

34

KoreaScience (Korea)

Full Text Available

2008-03-01

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Tamsulosin oral controlled absorption system (OCAS) in the treatment of benign prostatic hypertrophy

Single Particle Tracking of ?7 Nicotinic AChR in Hippocampal Neurons Reveals Regulated Confinement at Glutamatergic and GABAergic Perisynaptic Sites

The efficacy of tamsulosin at the cost of a relatively benign side effect profile has been attributed to receptor selectivity directed at the b1;_1a and b1;_1d adrenergic...Full Text Available

2008-02-01

36

Serum Globotriaosylceramide Assay as a Screening Test for Fabry Disease in Patients with ESRD on Maintenance Dialysis in Korea

b1;7 neuronal nicotinic acetylcholine receptors (b1;7-nAChR) form Ca²⁺-permeable homopentameric channels modulating cortical network activity and cognitive processing....Full Text Available

37

Rosiglitazone and fenofibrate improve insulin sensitivity of pre-diabetic OLETF rats by reducing malonyl-CoA levels in the liver and skeletal muscle

Background/AimsFabry disease is an X-linked recessive and progressive disease caused by b1;-galactosidase A (b1;-GaL A) deficiency. We sought to assess the prevalence...Full Text Available

2010-12-01

38

Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction

AimsRosiglitazone and fenofibrate, specific agonists of the peroxisome proliferator activated receptors-γ (PPARγ) and -b1; (PPARb1;),...Full Text Available

2009-05-08

39

Modulation of Retinoic Acid Receptor-related Orphan Receptor ? and ? Activity by 7-Oxygenated Sterol Ligands*

Although peroxisome proliferator-activated receptor alpha (PPARb1;) is closely associated with myocardial fatty acid metabolism, the pathophysiological role of PPARb1; in myocardial infarction...Full Text Available

2003-01-01

40

Induction of Porphyrin Synthesis in Etiolated Bean Leaves by Chelators of Iron ¹²

The retinoic acid receptor-related orphan receptors b1; and γ (RORb1; (NR1F1) and RORγ (NR1F3)) are orphan nuclear receptors and perform critical roles in regulation of development,...Full Text Available

2010-02-12

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Forkhead Box Transcription Factor FOXO3a Regulates Estrogen Receptor Alpha Expression and Is Repressed by the Her-2/neu/Phosphatidylinositol 3-Kinase/Akt Signaling Pathway

Primary leaves of 7- to 9-day-old etiolated seedlings of Phaseolus vulgaris L. var. Red Kidney infiltrated in darkness with aqueous solutions of b1;, b1;′-dipyridyl,...Full Text Available

1974-02-01

42

Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16?-hydroxyestrone ratio predictive for breast cancer?

The expression status of the estrogen receptor alpha (ERb1;) and that of the epidermal growth factor receptor Her-2/neu frequently correlate inversely in breast cancers. While ERb1;-dependent...Full Text Available

2004-10-01

43

Crystallization and preliminary X-ray diffraction studies of two thermostable ?-galactosidases from glycoside hydrolase family 36

Experimental studies have shown that two main estrogen metabolites hydroxylated by CYP1A1 and CYP1B1 in the breast differentially affect breast cell proliferation and carcinogenesis. Although 16b1;-hydroxyestrone...Full Text Available

44

Active Site of ?-Chymotrypsin Activation by Association-Desolvation

b1;-Galactosidases from thermophilic organisms have gained interest owing to their applications in the sugar industry. The b1;-galactosidases AgaA, AgaB and AgaA A355E mutant from Geobacillus...Full Text Available

45

Primary adenocarcinoma of the urinary bladder: value of cell cycle biomarkers.

High reactivity toward b1;-chymotrypsin is observed for derivatives of β-arylpropionic acids of varied structure—L-b1;-acylamido compounds, D-cyclized compounds, and, now,...Full Text Available

1970-06-01

46

A human TERT C-terminal polypeptide sensitizes HeLa cells to H2O2-induced senescence without affecting telomerase enzymatic activity.

Primary adenocarcinomas of the urinary bladder are uncommon, and the molecular pathways are currently not well defined. In this study, we assessed the association between biologic markers and clinicopathologic characteristics in a cohort of 21 patients with primary urinary bladder adenocarcinoma. Immunohistochemical staining for cell cycle-specific markers, including p53, p21, p27, Ki-67, and cyclin E, were performed on sections of a tissue microarray construct. The tumors were high grade in 12 (57%) and pT2 or higher in 18 (86%); lymph nodes were involved in 6 cases (29%); and there was pathologic evidence of schistosomiasis in 14 (67%). The best prognostic combination of markers was combined alterations in p27 and Ki-67 and was associated with stage (P = .012), grade (P = .005), DNA ploidy (P = .005), and lymph node involvement (P = .04). Stage, lymph node involvement, combined alterations of p27 and Ki-67, and combined alterations of all 5 biomarkers were ...

2011-06-01

47

Twist-1 is a PPAR ?-inducible, negative feedback regulator of PGC-1 ? in brown fat metabolism

We have constructed a 27-kDa hTERT C-terminal polypeptide (hTERTC27) devoid of domains required for telomerase activity and demonstrated that it is capable of nuclear translocation/telomere-end targeting. Here we showed that expression of a low level of hTERTC27 renders hTERT positive HeLa cells sensitive to H(2)O(2)-induced oxidative stress and subsequent cell senescence. The senescence-associated gene, the cyclin/cdk inhibitor p21(Waf1), was up-regulated. This occurs without changing the expression of endogenous hTERT, causing significant telomere shortening or inhibiting telomerase activity. Results from this study suggest for the first time that in addition to telomerase activity, the C-terminus of hTERT also plays a role in hTERT-mediated cellular resistance to oxidative stress. PMID:12565825

2003-02-14

48

Tumor necrosis factor-? serum levels in healthy smokers and nonsmokers

SummaryBrown fat is specialized in energy expenditure, a process that is principally controlled by the transcriptional co-activator PGC-1b1;. Here we describe a molecular...Full Text Available

2009-04-03

49

Therapeutic Vaccination in Chronic Hepatitis B: Preclinical Studies in the Woodchuck

Background:Tobacco smoking is the most important risk factor for chronic obstructive pulmonary disease (COPD) development. Inhaled cigarette smoke can induce tumor necrosis factor-b1;...Full Text Available

2010-01-01

50

The oncogenic transforming potential of the passage of single ? particles through mammalian cell nuclei

Recommended treatment of chronic hepatitis B with interferon-b1; and/or nucleos(t)ide analogues does not lead to a satisfactory result. Induction of HBV-specific T cells by therapeutic...Full Text Available

2010-01-01

51

The impact of linac output variations on dose distributions in helical tomotherapy

Domestic, low-level exposure to radon gas is considered a major environmental lung-cancer hazard involving DNA damage to bronchial cells by b1; particles from radon progeny. At domestic exposure...Full Text Available

1999-01-05

52

The effect of an ?-globulin preparation and of polyribonuclease complexes on humoral antibody formation

It has been suggested for quality assurance purposes that linac output variations for helical tomotherapy (HT) be within �b1;2% of the long-term average. Due to cancellation of systematic...Full Text Available

2008-01-21

53

The Melanocortin 3 Receptor: A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?

The effects of bovine b1;-globulin (BAG), bovine-ribonuclease serum albumin (BSA-RNase) and polyribonuclease (poly-RNase) complexes on the primary response of rodents to sheep erythrocytes have...Full Text Available

1968-06-01

54

The Effect of 5?-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen and Sexual Function in Healthy Young Men

The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 32.7 �b1; 3.7)...Full Text Available

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The Biosynthesis of ?-Aminolevulinic Acid in Chlorella¹

PurposeDutasteride and finasteride are 5b1;-reductase inhibitors that dramatically decrease serum levels of dihydrotestosterone. Because androgens...Full Text Available

2008-06-01

56

Synthesis, characterization and evaluation of antibacterial activity of some thiazolo[3,2-b][1,2,4]triazole incorporating diphenylsulfone moieties

When autotrophically growing cultures of Chlorella are treated with levulinic acid, δ-aminolevulinic acid is excreted into the medium, providing a direct demonstration of b1;-aminolevulinic...Full Text Available

1970-04-01

57

British Library Electronic Table of Contents (United Kingdom)

A series of thiazolo[3,2-b][1,2,4]triazole incorporating diphenylsulfone moieties were synthesized starting from 5-[4-(4-X-phenylsulfonyl)phenyl]-4H-1,2,4-triazole-3-thioles 3a-c, X=H, Cl, Br. Thus, alkylation of 1,2,4-triazoles 3 with phenacyl bromide or 4-bromophenacyl bromide afforded S-substituted 1,2,4-triazoles 4, 5. These new intermediates 4 and 5, in the presence of H2SO4 (c), were cyclized to 2-[4-(4-X-phenylsulfonyl)phenyl]-6-(4-Y-phenyl)[1,3]thiazolo[3,2-b]-[1, 2,4]-triazoles 6, 7 (I) and not to isomeric thiazolo[2,3-c][1,2,4]-triazoles 6, 7 (II). The newly synthesized compounds were characterized by IR, 1H, 13C NMR and elemental analysis. MS spectra confirmed the formation of thiazolo[3,2-b][1,2,4]triazole 6, 7 (forms I) in detriment of [2,3-c] isomeric compounds (forms II). Th...

2009-01-01

58

Structure of lipid bilayers

Stem Cell Therapies Benefit Alport Syndrome

The quantitative experimental uncertainty in the structure of fully hydrated, biologically relevant, fluid (L_b1;) phase lipid bilayers has been too large to...Full Text Available

2000-11-10

59

Selecting Folded Proteins from a Library of Secondary Structural Elements

Patients with Alport syndrome progressively lose renal function as a result of defective type IV collagen in their glomerular basement membrane. In mice lacking the b1;3 chain of type IV collagen...Full Text Available

2009-11-01

60

Regulation and Function of Escherichia coli Sugar Efflux Transporter A (SetA) during Glucose-Phosphate Stress?

A protein evolution strategy is described by which double-stranded DNA fragments encoding defined E. coli protein secondary structural elements (b1;-helices, β-strands...Full Text Available

2008-01-09

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61

Production, Purification, and Characterization of ?-Galactosidase from Monascus pilosus

Accumulation of certain nonmetabolizable sugar-phosphates (including b1;-methyl glucoside-6-phosphate) in Escherichia coli is growth inhibitory and elicits the glucose-phosphate...Full Text Available

2011-01-01

62

Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol

A Monascus pilosus strain was selected for production of intracellular b1;-galactosidase. Optimum conditions for mycelial growth and enzyme induction were determined. Galactose...Full Text Available

1986-11-01

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Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin

PurposeRadiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of PTX and b1;-tocopherol on...Full Text Available

2008-09-01

64

British Library Electronic Table of Contents (United Kingdom)

Estrogen metabolism is suggested to play an important role in estrogen-induced breast carcinogenesis. Epidemiologic studies suggest that diets rich in phytoestrogens are associated with a reduced risk of breast cancer. Phytoestrogens are biologically active plant compounds that structurally mimic 17b-estradiol (E2). We hypothesize that phytoestrogens, may provide protection against breast carcinogenesis by altering the expression of estrogen-metabolizing enzymes cytochrome P450 1A1 (Cyp1A1) and 1B1 (Cyp1B1). Cyp1A1 and Cyp1B1 are responsible for the metabolism of E2 to generate 2-hydroxyestradiol (2-OHE2) and 4-hydroxyestradiol (4-OHE2), respectively. Studies suggest that 2-OHE2 and 2-methoxyestradiol may protect against breast carcinogenesis, while 4-OHE2 is carcinogenic in rodent models....

2008-01-01

65

Orgasm is preserved regardless of ejaculatory dysfunction with selective ?1A-blocker administration

Noncooperativity of the ?? Dimer in the Reaction of Hemoglobin with Oxygen

We evaluated whether ejaculatory dysfunction induced with a selective b1;1A-blocker influenced orgasm. Fifteen healthy male volunteers took silodosin or a placebo in a randomized, double-blind...Full Text Available

2009-09-01

66

Metal Ions-Stimulated Iron Oxidation in Hydroxylases Facilitates Stabilization of HIF-1? Protein

The theory that the b1;β dimer is the functional unit of cooperativity in hemoglobin has been tested by determination of the oxygen equilibrium curve of stable deoxy dimers, obtained by...Full Text Available

1972-01-01

67

Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages?

The exposure of cells to several metal ions stabilizes HIF-1b1; protein. However, the molecular mechanisms are not completely understood. They may involve inhibition of hydroxylation by either...Full Text Available

2009-02-01

68

Interaction of Heparins and Dextran Sulfates with a Mesoscopic Protein Nanopore

Host cells use metabolic signaling through the LXRb1; nuclear receptor to defend against Listeria monocytogenes infection. 25-Hydroxycholesterol is a natural ligand of LXRs that...Full Text Available

2011-04-01

69

Independence of extracellular tortuosity and volume fraction during osmotic challenge in rat neocortex

AbstractA mechanism of how polyanions influence the channel formed by Staphylococcus aureus b1;-hemolysin is described. We demonstrate that the probability of several...Full Text Available

2009-12-02

70

Finasteride-Its Impact on Sexual Function and Prostate Cancer

The structural properties of brain extracellular space (ECS) are summarised by the tortuosity (λ) and the volume fraction (b1;). To determine if these two parameters were independent,...Full Text Available

2002-07-15

71

Enantioselective organocatalytic ?-sulfenylation of substituted diketopiperazines

Finasteride, a specific and competitive inhibitor of 5b1;-reductase enzyme Type 2, inhibits the conversion of testosterone to dihydrotestosterone (DHT). In adults, DHT acts as primary androgen...Full Text Available

2009-01-01

72

Crystallization and preliminary X-ray analysis of human liver ?-enolase

The asymmetric organocatalytic b1;-sulfenylation of substituted piperazine-2,5-diones is reported, with cinchona alkaloids as chiral Lewis bases and electrophilic sulfur transfer reagents....Full Text Available

2009-12-11

73

Critical role of SDF-1?-induced progenitor cell recruitment and macrophage VEGF production in the experimental corneal neovascularization

Enolase is a multifunctional enzyme that plays important roles in many biological and disease processes. b1;-Enolase from human liver (hENO1) was expressed as a soluble protein and purified by...Full Text Available

74

Characteristics of Galacturonic Acid Oligomers as Elicitors of Casbene Synthetase Activity in Castor Bean Seedlings 1

PurposeTo address the roles of the stromal derived factor-1 (SDF-1) b1; in the course of experimental corneal neovascularization (CNV).MethodsCNV...Full Text Available

75

Calcium/Calmodulin-Dependent Protein Kinase II Mediates Hippocampal Glutamatergic Plasticity During Benzodiazepine Withdrawal

Partial digestion of polygalacturonic acid with polygalacturonase isolated from Rhizopus stolonifer produces a mixture of b1;-1,4-d-galacturonide oligomers which act...Full Text Available

1984-04-01

76

Butyrate Induces Expression of 17?-Hydroxysteroid Dehydrogenase Type 1 in HT29 and SW707 Colorectal Cancer Cells

Benzodiazepine withdrawal anxiety is associated with potentiation of b1;-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) currents in hippocampal CA1 pyramidal...Full Text Available

2010-08-01

77

British Library Electronic Table of Contents (United Kingdom)

Epidemiological studies have revealed that butyrate and 17?-estradiol (E2) may decrease the incidence of colorectal cancer (CRC). In peripheral tissue, E2 can be produced locally by 17?-hydroxysteroid dehydrogenase 1 (HSD17B1) estrone (E1) reduction. Using quantitative real-time polymerase chain reaction and western blotting analysis, we found that sodium butyrate significantly upregulates HSD17B1 long and short transcripts and protein levels in HT29 and SW707 CRC cells. Chromatin immunoprecipitation analysis showed that upregulation of these transcript levels correlated with an increase in binding of Polymerase II to proximal and distal promoters of HSD17B1. Moreover, we observed that upregulation of HSD17B1 protein levels was associated with increased conversion of E1 to E2 in HT29 and S...

2011-01-01

78

B-1 Primary Safety

Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis

... Page 2. Boston Scientific CRM 11/17/09 MADIT-CRT Clinical Report APPENDIX B 2 CONFIDENTIAL ... B-2 Primary Effectiveness B-2.1 Validation of Assumptions ...

79

Ammonia adsorption on the C_3_0B_1_5N_1_5 heterofullerene: DFT study of nuclear magnetic shielding and electric field gradient tensors of N and B nuclei

IntroductionBRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known...Full Text Available

2010-01-01

80

Alpha-Hemoglobin-Stabilizing Protein: An Erythroid Molecular Chaperone

Ammonia adsorption on the external surface of C_3_0B_1_5N_1_5 heterofullerene was studied using density functional calculations. Three models of the ammonia-attached C_3_0B_1_5N_1_5 together with the perfect model were optimized at the B3LYP/6-31G"* level. The optimization process reveals that dramatic influences occurred for the geometrical structure of C_3_0B_1_5N_1_5 after ammonia adsorption; the B atom relaxes outwardly and consequently the heterofullerene distorts from the spherical form in the adsorption sites. The chemical shielding (CS) tensors and nuclear quadrupole coupling constants of B and N nuclei were calculated at the B3LYP/6-311G"*"* level. Our calculations reveal that the B atom is chemically bonded to NH_3 molecule. The B atom in the NH_3-attached form has the largest chemical shielding isotropic (CSI) value among the other boron nuclei. The ...

2011-04-01

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81

ADP-Glucose Pyrophosphorylase, a Regulatory Enzyme for Bacterial Glycogen Synthesis

Alpha-hemoglobin-stabilizing protein (AHSP) is an erythroid-specific protein that acts as a molecular chaperone for the free b1; chains of hemoglobin. Evidence strongly suggests...Full Text Available

2011-01-01

82

A homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, ? cell hyperplasia, and islet cell tumor

The accumulation of b1;-1,4-polyglucans is an important strategy to cope with transient starvation conditions in the environment. In bacteria and plants, the synthesis of glycogen and starch occurs...Full Text Available

2003-06-01

83

A T to A base substitution and small deletions in the conalbumin TATA box drastically decrease specific in vitro transcription.

ObjectiveThe goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic b1; cell hyperplasia...Full Text Available

2009-11-01

84

A Review of the Biochemistry, Metabolism and Clinical Benefits of Thiamin(e) and Its Derivatives

We have previously shown that a T to G transversion at the second T of the conalbumin "TATA" box drastically decreases specific initiation of transcription by RNA polymerase B (1). We now report that...Full Text Available

1981-04-24

85

A Novel Form of Transcriptional Silencing by Sum1-1 Requires Hst1 and the Origin Recognition Complex

Thiamin(e), also known as vitamin B1, is now known to play a fundamental role in energy metabolism. Its discovery followed from the original early research on the ‘anti-beriberi factor’...Full Text Available

2006-03-01

86

A Conserved Role for Phosphoinositide-3-Kinase but Not Akt Signaling in Mitochondrial Adaptations that Accompany Physiological Cardiac Hypertrophy

In the yeast Saccharomyces cerevisiae, a and b1; mating-type information is stored in transcriptionally silenced cassettes called HML and HMR....Full Text Available

2001-05-01

87

?-Blocker Use Is Associated With Decreased Risk of Sexual Dysfunction

Physiological cardiac hypertrophy is associated with mitochondrial adaptations that are characterized by activation of PGC-1b1; and increased fatty acid oxidative (FAO) capacity. It is...Full Text Available

2007-10-01

88

Theoretical study of the phonon properties of SrS

OBJECTIVESTo examine the association between b1;-blocker use and sexual dysfunction among men participating in a population-based cohort of...Full Text Available

2009-07-01

89

Nanocrystallization of the amorphous Fe_1_4Ni_4_0Zr_7B_1_2 alloys studied by the Moessbauer spectroscopy

Using an ab initio pseudopotential method within a generalized gradient approximation of the density functional theory, the structural, electronic, and phonon properties of SrS in the B1 (NaCl) and B2 (CsCl) structures have been studied. The calculated lattice constants, static bulk modulus, and first-order pressure derivative of the bulk modulus are reported for both the B1 and B2 structures and compared with previous experimental and theoretical calculations. Electronic band structures and densities of states have been derived for SrS. Subsequently, a linear-response approach to the density functional theory is used to derive the phonon frequencies and densities of states.

2009-05-25

90

Moessbauer study of magnetic anisotropy in amorphous Fe_4_0Ni_3_8Mo_4B_1_8 (METGLAS 2628MB)

Formation of the soft magnetic nanostructure in amorphous Fe_1_4Ni_4_0Zr_7B_1_2 alloy due to heat treatment is studied by the Moessbauer, differential scanning calorimetry, and X-ray diffraction techniques. Annealing at temperatures 520-580 "oC leads to the formation of extremely soft nanocrystalline alloy as revealed by the rf-Moessbauer measurements. The superparamagnetic behaviour was observed for the alloy annealed at 620-640 "oC. At higher annealing temperatures good soft magnetic properties deteriorate. (author)

2001-09-23

91

Treatment of low-frequency pulsating magnetic field on amorphous alloy Fe_7_8Si_9B_1_3

The room-temperature anisotropy of amorphous Fe_4_0Ni_3_8Mo_4B_1_8 (METGLAS 2628MB) ribbons after various heat treatments has been studied by Moessbauer spectroscopy. The average magnetization direction becomes significantly more out-of-plane after heating above 650 K but below the crystallization temperature. X-ray diffractograms suggest an atomic rearrangement has occurred. (orig.).

92

Monoenergetic Gamma-Rays from Non-Minimal Kaluza-Klein Dark Matter Annihilations

Effect of low-frequency pulsating magnetic field on the microstructure and magnetic properties of amorphous alloy Fe_7_8Si_9B_1_3 were investigated. The temperature rise induced by the treatment was measured by a non-contact infrared thermometer. The crystallization behavior and microstructure of specimens were studied by Moessbauer spectroscopy and transmission electron microscope (TEM). Magnetic properties of the specimens were investigated by alternating gradient magnetometer (AGM). The results show that the low-frequency pulsating magnetic field can promote the single-phase crystallization of amorphous alloy Fe_7_8Si_9B_1_3. The frequency, f of applied field is from 10 to 40 Hz, magnetic field, H is from 0.02 to 0.04 T and treatment duration, t is from 180-300 s. The volume fraction of crystallization phase (#alpha#-Fe(Si), the grain size, 2-10 nm) is 3-7%. The temperature rise less than 7 deg. C. ...

2007-07-15

93

Hepatic aflatoxin B1-DNA adducts and TP53 mutations in patients with hepatocellular carcinoma despite low exposure to aflatoxin B1 in southern Japan

We investigate monoenergetic gamma-ray signatures of Z^1 dark matter annihilations in a non-minimal Universal Extra Dimensions model. The self-interactions of the non-Abelian Z^1 gauge boson give rise to a large number of contributing Feynman diagrams that do not exist for annihilations of the Abelian gauge boson B^1, which is the standard Kaluza-Klein dark matter candidate. We find that the annihilation rate is indeed considerably larger for the Z^1 than for the B^1. Even though relic density calculations indicate that the mass of the Z^1 should be larger than the mass of the B^1, the predicted fluxes are of the same order of magnitude. We compare our results to existing experimental limits, as well as to future sensitivities, for image air Cherenkov telescopes, and we find that the limits are reached already with a moderately large boost factor. However, the ...

2011-01-01

94

British Library Electronic Table of Contents (United Kingdom)

Abstract Background & aims: Hepatitis B or C virus infection is considered to be the main cause of hepatocellular carcinoma (HCC) in Japan. Aflatoxin B1 (AFB1) is a carcinogen associated with HCC in regions with high exposure. Mutations in codon 249, exon 7 are a hallmark of AFB1 exposure. Therefore, to clarify the role of AFB1 in hepatocarcinogenesis, we examined AFB1-DNA in liver tissue and sequenced TP53 in Japanese patients with HCC. Methods: Hepatocyte AFB1-DNA adducts were determined immunohistochemically and direct sequencing of TP53 was done to determine mutations in 188 of 279 patients who underwent hepatic resection for HCC. We assessed hepatitis C virus antibodies (HCV Ab) and HBSAg expression; patients without either were defined as having non-B non-C hepatocellular carcinoma (...

2011-01-01

95

Real-time neutron diffraction study of crystallization kinetics in amorphous Fe_7_8B_1_3Si_9 alloy

Measurements of bragg curve for 75 MeV/u "1"2C ion beam and its inactivation effect on melanoma cells

The transformation from the as-quenched amorphous to the crystalline state in Fe_7_8B_1_3Si_9 alloy has been investigated using a new-type neutron diffractometer. The time resolved diffraction patterns clearly show that this alloy crystallizes into FeSi alloy and Fe_2B in that order. The time evolution of these crystalline phases can be analyzed by the Kolmogorov-Johnson-Mehl-Avrami equation with the exponent of about 2.5 over a wide temperature range. This suggests that the crystallization occurs by the diffusion-controlled growth with a constant nucleation rate. The scaling behavior in the crystallization kinetics is also discussed. (author).

1987-01-01

96

Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers

Relative doses of 75 MeV/u "1"2C ion beam after passing through different thickness of degraders were measured with the double ionization chamber method. The degrader's thickness equalized to penetration depth of the beam in water and its Bragg curve were obtained. The measured Bragg curve is compared with that calculated based on a model set up by the authors. Meanwhile, the inactivation effect of the ion beam passing through different thickness of degraders on melanoma (B_1_6) cells was measured, and the corresponding survival fraction data for B_1_6 cells were acquired

1998-08-01

97

British Library Electronic Table of Contents (United Kingdom)

Human heat shock protein 27 (Hsp27, HspB1) is an anti-apoptotic protein characterized for its tumorigenic and metastatic properties, and now referenced as a major therapeutic target in many types of cancer. Hsp27 biochemical properties rely on a structural oligomeric and dynamic organization. Downregulation by small interfering RNA or inhibition with dominant-negative mutant have proven their efficiency to counteract the anti-apoptotic and protective properties of Hsp27. In this study, we report the isolation and characterization of Hsp27-targeted molecules interfering with its structural organization. Using the peptide aptamer (PA) strategy, we isolated PAs that specifically interact with Hsp27 and not with the other members of the small heat shock protein family. In mammalian cell cultur...

2011-01-01

98

The p75"N"T"R tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells

The PISA experiment-spallation products identified by Bragg curve spectroscopy

The p75 neurotrophin receptor (p75"N"T"R) is a death receptor which belongs to the tumor necrosis factor receptor super-family of membrane proteins. This study shows that p75"N"T"R retarded cell cycle progression by induced accumulation of cells in G0/G1 and a reduction in the S phase of the cell cycle. The rescue of tumor cells from cell cycle progression by a death domain deleted (#DELTA#DD) dominant-negative antagonist of p75"N"T"R showed that the death domain transduced anti-proliferative activity in a ligand-independent manner. Conversely, addition of NGF ligand rescued retardation of cell cycle progression with commensurate changes in components of the cyclin/cdk holoenzyme complex. In the absence of ligand, p75"N"T"R-dependent cell cycle arrest facilitated an increase in apoptotic nuclear fragmentation of the prostate cancer cells. Apoptosis of p75"N"T"R expressing cells occurred via the intrinsic mitochondrial pathway leading to a sequential caspase-9 and ...

2006-03-24

99

A modified immunoblot method to identify substrates of protein kinases

No abstract prepared.

2004-07-01

100

KoreaScience (Korea)

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101

The hrpK Operon of Pseudomonas syringae pv. tomato DC3000 Encodes Two Proteins Secreted by the Type III (Hrp) Protein Secretion System: HopB1 and HrpK, a Putative Type III Translocator

The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

Pseudomonas syringae is a gram-negative bacterial plant pathogen that is dependent on a type III protein secretion system (TTSS) and the effector proteins it translocates into plant...Full Text Available

2005-01-01

102

Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality

Werner syndrome (WS) is a rare disorder characterized by the premature onset of several pathologies associated with aging. The gene responsible for WS codes for a RecQ-type DNA helicase and is believed...Full Text Available

103

Terpenoid-based defenses in conifers: cDNA cloning, characterization, and functional expression of wound-inducible (E)-?-bisabolene synthase from grand fir (Abies grandis)

When the vehicle-treated, sham-operated mice underwent heat stress, the fraction survival and core temperature at +4 h of body heating were found to be 5 of 15 and 34.4°C �b1; 0.3°C,...Full Text Available

2010-01-01

104

Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation

(E)-b1;-Bisabolene synthase is one of two wound-inducible sesquiterpene synthases of grand fir (Abies grandis), and the olefin product of this cyclization reaction...Full Text Available

1998-06-09

105

Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole

BackgroundAdipokines, e.g. TNFb1;, IL-6 and leptin increase insulin resistance, and consequent hyperinsulinaemia influences breast cancer progression. Beside its mitogenic...Full Text Available

106

Scaling properties of cell and organelle size

Two novel crystal structures of Zea mays protein kinase CK2b1; catalytic subunit, one in complex with the specific inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) and another...Full Text Available

2001-11-01

107

Replication, Pathogenesis and Transmission of Pandemic (H1N1) 2009 Virus in Non-Immune Pigs

How size is controlled is a fundamental question in biology. In this review, we discuss the use of scaling relationships—for example, power-laws of the form y∝x^b1;—to...Full Text Available

2010-04-01

108

Quality assurance requirements for the computer software and safety analyses

The declaration of the human influenza A pandemic (H1N1) 2009 (H1N1/09) raised important questions, including origin and host range b;1],...Full Text Available

109

Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity

The requirements are given as placed on the development, procurement, maintenance, and application of software for the creation or processing of data during the design, construction, operation, repair, maintenance and safety-related upgrading of nuclear power plants. The verification and validation processes are highlighted, and the requirements put on the software documentation are outlined. The general quality assurance principles applied to safety analyses are characterized. (J.B.). 1 ref.

110

On the Origins of the Weak Folding Cooperativity of a Designed ??? Ultrafast Protein FSD-1

BackgroundTo evaluate whether P2X receptors are involved in responses to noxious pulp stimulation, the P2X₃and P2X_2/3receptor agonist b1;,β-methyleneATP...Full Text Available

111

Neuroactive steroids have multiple actions to potentiate GABA_A receptors

FSD-1, a designed small ultrafast folder with a ββb1; fold, has been actively studied in the last few years as a model system for studying protein folding mechanisms and for testing...Full Text Available

2010-11-01

112

MicroRNAs Regulate Human Hepatocyte Nuclear Factor 4?, Modulating the Expression of Metabolic Enzymes and Cell Cycle*

The effects of neuroactive steroids on the function of GABA_A receptors were studied using cell-attached records of single channel activity recorded from HEK293 cells transfected with b1;1...Full Text Available

2004-07-01

113

Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and ?₂-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies

Hepatocyte nuclear factor (HNF) 4b1; is a key transcription factor regulating endo/xenobiotic-metabolizing enzymes and transporters. We investigated whether microRNAs are involved in the regulation...Full Text Available

2010-02-12

114

Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation

The immunolocalization of the low density lipoprotein receptor-related protein 1 (LRP1) and its ligand alpha 2-Macroglobulin (b1;₂M) was examined in tissues from human donor...Full Text Available

2010-08-01

115

Degradation of ?-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26

BackgroundEstrogen receptors alpha (ERb1;) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype...Full Text Available

116

DIMINISHED DEGRADATION OF MYELIN BASIC PROTEIN BY ANTI-SULFATIDE ANTIBODY AND INTERFERON-? IN MYELIN FROM GLIA MATURATION FACTOR-DEFICIENT MICE

β-Hexachlorocyclohexane (β-HCH) is the most recalcitrant among the b1;-, β-, γ-, and δ-isomers of HCH and causes serious environmental pollution problems....Full Text Available

2005-04-01

117

Complete Nucleotide Sequence of an Exogenously Isolated Plasmid, pLB1, Involved in ?-Hexachlorocyclohexane Degradation?

In this study we show the effect of anti-sulfatide (RmAb) antibodies and inflammatory cytokines, TNF-b1; and IFN-γ in inducing myelin basic protein (MBP) degradation in myelin...Full Text Available

2007-06-01

118

Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed

The b1;-proteobacterial strain Sphingobium japonicum UT26 utilizes a highly chlorinated pesticide, γ-hexachlorocyclohexane (γ-HCH), as a sole source of carbon...Full Text Available

2006-11-01

119

Alternative mRNA Splicing Produces a Novel Biologically Active Short Isoform of PGC-1?*

In the isolated rat mesenteric bed, the 1 min perfusion with 100 nm anandamide, a concentration that did not evoke vasorelaxation, elicited an acute release of 165.1 �b1; 9.2 pmol nitric...Full Text Available

2005-10-15

120

The transcriptional co-activator PGC-1b1; regulates functional plasticity in adipose tissue by linking sympathetic input to the transcriptional program of adaptive thermogenesis. We report here...Full Text Available

2009-11-20

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121

?_1A/B-Knockout mice explain the native ?_1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other ?₁-subtypes

PurposePrevious studies have demonstrated that in 129b1;3Cx46^−/− mice, age-related nuclear cataract is formed. In...Full Text Available

2007-06-01

122

?₁-Fetoprotein Transcription Factor (FTF)/Liver Receptor Homolog-1 (LRH-1) Is an Essential Lipogenic Regulator

Background and purpose:Theoretically, three b1;₁-adrenoceptor subtypes can interact at the signalling level to alter vascular contraction or at the molecular level...Full Text Available

2009-12-01

123

In vitro and in vivo analysis of pegulated Avidin

b1;₁-Fetoprotein transcription factor (FTF), also known as liver receptor homolog 1 (LRH-1) is highly expressed in liver and intestine, where it is implicated in the regulation...Full Text Available

2010-04-01

124

Enhanced corrosion resistance of Fe_4_0Ni_3_8Mo_4B_1_8 and Nd_1_5Fe_7_7B_8 by laser glazing

Full text: In 1995, we demonstrated the use of pretargetting three steps method and biotinylated tetracycline using radiolabelled {sup 99m}Tc-DTPA-biocytinamide for the detection of tumour cells in (C57B1/6 x BALB/C) F1 mice with E-3 thymoma. The three steps were (1) IP injection of biotinylated-tetracycline conjugate (1:1) ratio, (2) 96 hours later Avidin/Streptavidin was injected, and (3) 24 hours after (2), {sup 99m}Tc-biocytinamide -cDTPA was injected. Mice were sacrificed 16/24 h after (3) by cervical dislocation. Biodistribution of radioactivity tumour to blood, liver, bone were T:B1= 15.0, T:Li= 5.08, T:Bo=15.0. The percentage of injected dose per g was T= 3.15% and B1= 0.21%. To prolong circulation of Avidin and therefore its uptake into tumour, Avidin was covalently bound to polyethylene-glycol (PEG20 KD) at the molar ratio of PEG:Avidin 100:1 and ...

1997-09-01

125

Effect of butylated hydroxytoluene pretreatment on the excretion, tissue distribution and DNA binding of (/sup 14/C)aflatoxin B1 in the rat

Laser glazing, using a KrF excimer laser (> = 248 nm, >a = 22 ns), has been used to improve the corrosion resistance properties of crystallized Fe_4_0Ni_3_8Mo_4B_1_8 (Metglas 2826 MB) and the permanent magnet material Nd_1_5Fe_7_7B_8. The formation of an amorphous layer was confirmed by conversion-electron Mossbauer Spectroscopy (CEMS), and the thickness of the amorphous layer was determined from the attenuation of the x-rays diffracted from the underlying crystalline material. The variation with laser fluence of the amorphous layer thickness on the Metglas were measured. The corrosion properties of the original, crystalline and laser glazed Metglas were measured potentiodynamically in acid electrolyte. Similar voltametric characteristics were obtained for the laser glazed surface and original Metglas, both showing a lower current in the passive region than the crystalline material. Laser glazing of the Nd_1_5Fe_7_7B_8 also produced a ...

1988-09-21

126

Antifungal thiopeptide cyclothiazomycin B1 exhibits growth inhibition accompanying morphological changes via binding to fungal cell wall chitin

The effect of butylated hydroxytoluene (BHT) pretreatment (0.5% in the diet for 10 days) on the excretion, tissue distribution and DNA binding of orally administered (/sup 14/C)aflatoxin B1 (AFB1) was determined in male Fischer F344 rats. The amount of radioactivity excreted in the urine and feces by 24 hr was higher in BHT-treated rats than in controls. Treatment with BHT enhanced the excretion of water-soluble metabolites in the urine and in the large intestines plus feces at the earlier sampling times. The amount of radioactivity bound to hepatic nuclear DNA was six times less in the BHT-pretreated rats than in controls 6 hr after administration of the isotope. The half-lives of (/sup 14/C)DNA in the rat liver were 30 and 46 hr for control and BHT-pretreated rats, respectively. These results indicate that BHT pretreatment may protect the animal from the carcinogenic effects of AFB1 by enhancing the detoxification and excretion of the ...

1985-06-01

127

British Library Electronic Table of Contents (United Kingdom)

Cyclothiazomycin B1 (CTB1) is an antifungal cyclic thiopeptide isolated from the culture broth of Streptomyces sp. HA 125-40. CTB1 inhibited the growth of several filamentous fungi including plant pathogens along with swelling of hyphae and spores. The antifungal activity of CTB1 was weakened by hyperosmotic conditions, and hyphae treated with CTB1 burst under hypoosmotic conditions, indicating increased cell wall fragility. CTB1-sensitive fungal species contain high levels of cell wall chitin and/or chitosan. Unlike nikkomycin Z, a competitive inhibitor of chitin synthase (CHS), CTB1 did not inhibit CHS activity. Although CTB1 inhibited CHS biosynthesis, the same result was also obtained with a non-specific proteins inhibitor, cycloheximide, which did not reduce cell wall rigidity. These ...

2011-01-01

128

String thermal tachyons as multiparticle instabilities

Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens

The bosonic string on R"2"5xS"1 has a series of states turning tachyonic at radii implying T=IT_H. We employ the B picture to examine these thermal states in the one-loop free energy and find them in various combinations, factorizing towards rational points on the real line boundary of the fundamental domain B: (-1/2=# 0). These thermal tachyons are interpreted as signaling Hagedorn instabilities against the production of an l-highly-excited-identical-strings state, which gives a relation between the one-loop partition function and l-point functions. (orig.).

129

A neighborhood condition on all fractional $[a,b]$-factors

Several compounds were evaluated in nonhuman primates for their potential to induce neoplasms, especially hepatocellular carcinoma (HCC). The compounds can be classified into three groups: food contaminants, model rodent carcinogens, and nitrosamines. All three compounds in the food contaminants group, namely, aflatoxin B1, sterigmatocystin, and methylazoxymethanol acetate, induced HCC. None of the model rodent carcinogens tested consistently induced HCC in rhesus and cynomolgus monkeys. Three of four nitrosamines evaluated induced HCC in rhesus and cynomolgus monkeys. One nitrosamine, diethylnitrosamine, is a predictable and potent inducer of HCC and is useful for establishment of a nonhuman primate model for numerous oncologic studies.

1989-01-01

130

A High Throughput Combinatorial Library Technique for Identifying Formalin-Sensitive Epitopes

In this note, we derive from Anstee's fractional $(g,f)$-factor theorem a similar characterization for the property of all fractional $(g,f)$-factors. Let $ab-1)^2+4b)$ and every pair of non-adjacent vertices has cardinality of the neighborhood union at least $bn/(a + b)$. This lower bounds are sharp.

2011-01-01

131

Dose conversion factor for radon concentration in indoor environments using a new equation for the F-f_p correlation

We present a technique for identifying the amino acids responsible for a loss of immunoreactivity in response to treating an antigen with a chemical modifier. This is of particular interest...Full Text Available

2006-12-20

132

Acid-base behavior of the ground and excited states of platinum(II) complexes of quinoxaline-2,3-dithiolate

Since 1994 the radon studies group at the Institut de Techniques Energetiques (INTE) of the Universitat Politecnica de Catalunya in Barcelona, Spain, has carried out a campaign of continuous measurements of the equilibrium factor (F) and the unattached fraction (f_p) of radon decay products at four sites which are representative of different environmental characteristics on the Mediterranean littoral of Catalonia, Spain. It has been established that these parameters vary widely, F(0.03--0.87) and f_p (0--0.72), from one site to another and with time, according to the characteristics on the site and climate. In spite of this variation, the F and f_p parameters are log-normally or normally distributed. The measurements of F and f_p show that f_p is negatively correlated to F by a log-power equation, Ln(1/f_p)=1.90[Ln(1/F)]"-"0"."6"8, which can be used in all the F range, instead of the commonly used power equation f_p=aF"b suggested by Stranden and Strand and other authors, which fits ...

2000-01-01

133

Identifying Contributing Degradation Phenomena in PEM Fuel Cell Membrane Electrode Assemblies Via Electron Microscopy

The acid-base behavior of the ground and excited states of Pt(qdt){sub 2}{sup 2{minus}} and Pt(phen)(qdt), where qdt=quinoxaline-2,3-dithiolate and phen = 1,10-phenanthroline, has been studied. The pH-dependent changes in the charge-transfer absorption and emission spectra for both complexes are attributed to protonation of the quinoxalinedithiolate ligand at the imine nitrogen. For Pt(qdt){sub 2}{sup 2{minus}}, single protonation leads to a large red shift (2582 cm{sup {minus}1}) of the low-energy charge-transfer-to-dithiolate absorption band and the emergence of a new red-shifted emission feature at 728 nm. In solutions of pH below 6, a second protonation takes place at the other qdt ligand, yielding Pt-(Hqdt){sub 2}. This neutral complex has been isolated and characterized by {sup 1}H NMR spectroscopy and elemental analyses. The ground-state basicity constants of the two protonation steps have been determined from spectrophotometric titrations to be pK{sub ...

1995-06-21

134

High resolution line shapes of weak autoionizing resonances identified through fluorescence from the satellite states of Ar+

No abstract prepared.

2006-10-01

135

Development and evaluation of a conditionally lethal transgenic pink bollworm

No abstract prepared.

1997-07-01

136

Quantitative RT-PCR Expression Analysis of Lipodepsipeptides Synthetase and Defence-related Genes in Orange Fruit in Response to Antagonist-pathogen Interaction

A new area-wide pest control strategy using the pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae), genetically transformed with a conditionally lethal gene, is under development. Conditional lethality of several transgenic pink bollworm strains was demonstrated in a series of laboratory rearing experiments. Pink bollworms were transformed with genetic constructs using the RIDL technology (Release of Insects with a Dominant Lethal gene) for development of an autocidal biological control system for possible supplement or replacement of radiation based sterile insect release. LA1124 is a lethal construct controlled by a tetracycline repressible transactivator protein (tTA), in which binding of tTA to its specific target sequence tetO drives production of more tTA. In the absence of tetracycline, this leads to lethality by high expression of tTA. When tetracycline is present, tTA does not bind tetO, and so the positive feedback cycle is not established and tTA ...

2005-05-09

137

British Library Electronic Table of Contents (United Kingdom)

Abstract Strains of Pseudomonas syringae are effective in controlling postharvest diseases of citrus fruits, and antagonistic activity has been correlated with in vitro production of lipodepsipeptides. Additionally, biocontrol agents can induce a range of defence mechanisms of resistance in citrus tissue that result in a broad spectrum of metabolic modifications, such as systemic acquired resistance, induced systemic resistance and production of reactive oxygen species. The aim of this study was to evaluate the expression of syringomycin (syrB1) and syringopeptin (sypA) synthetase genes from P.syringae pv. syringae biocontrol strains in vitro on different culture media and in vivo on citrus fruits (Citrus sinensis cv. Tarocco) during the interaction with Penicillium digitatum by quantitati...

2011-01-01

138

Phase stability, electronic and elastic properties of ScN

Parametric upconversion of TM and Trivelpiece-Gould (TG) modes to high frequency Free Electron Laser (FEL)

The structural stability, electronic and elastic properties of ScN under high pressure were investigated by using full-potential linearized augmented plane-wave (FP-LAPW) method. Our calculations indicate that there exists a pressure-induced structural phase transformation from the ambient rock-salt (B1) phase to CsCl-type (B2) phase above 335 GPa. The origin of moderate high bulk modulus, mechanical and high melting point was analyzed by electronic properties. The variations of elastic constants (C_i_j) with volume and pressure have been investigated. Moreover, the volume dependencies of Debye temperature, the longitudinal and transverse elastic wave velocities have been presented.

2010-06-01

139

BRE: Consultation on the Green Guide update

A backward wave oscillator (BWO) filled with a strongly magnetized plasma supports TM and Trivel-piece-Gould (TG) modes. At large amplitudes these modes may act as wigglers for generating millimeter waves via free electron laser instability. The nonlinear coupling between the wiggler, the beam space charge mode, and the high frequency free electron laser wave is dominated by parallel motions. In the Raman regime the growth rate of instability goes as #approx##omega#_p_b"1"/"2/#gamma#_o"9"/"4, where #omega#_p_b is the beam plasma frequency and #gamma#_o is the relativistic gamma factor.

140

Robust consensus clustering for identification of expressed genes linked to malignancy of human colorectal carcinoma

...Content 3a LCA Methodology - Characterisation(PDF) 3a1 BRE Response - Characterisation 3b LCA Methodology - Normalisation (PDF) 3b1 BRE Response - Normalisation 3c LCA Methodology - Weighting (PDF) 3c1 Feedback - Weighting 3c2 Weightings Exercise (PDF) 4 Specification (PDF) 4a - Functional Units Spreadsheet (Excel) 4b Specification List (Excel) 5 Energy Model (PDF) 6 Whole Life perfomance 6b Response Note To Briefing Note 6 - Whole Life Performance (PDF) 7 End-of-Life and Waste models (PDF) 7a Waste routes and rates feedback (PDF) 7b Waste Disposal Routes for Industry Consultation 7c Site Wastage Rates for Industry Consultation 8 Existing LCA ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

141

Multilevel support vector regression analysis to identify condition-specific regulatory networks

Previous studies have been conducted in gene expression profiling to identify groups of genes that characterize the colorectal carcinoma disease. Despite the success of previous attempts to identify...Full Text Available

142

Light duty utility arm startup plan

Motivation: The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify...Full Text Available

2010-06-01

143

Large-scale cross-species oncogenomics identifies candidate oncogenes and tumor suppressor genes

This plan details the methods and procedures necessary to ensure a safe transition in the operation of the Light Duty Utility Arm (LDUA) System. The steps identified here outline the work scope and identify responsibilities to complete startup, and turnover of the LDUA to Characterization Project Operations (CPO).

1998-09-01

144

Intelligent techniques applied in identifying fraudsters industrial consumers of electricity; Tecnicas inteligentes aplicadas na identificacao de consumidores industriais fraudadores de energia eletrica

While genomic alterations identified in human tumors using techniques such as comparative genomic hybridisation (CGH) may be recurrent, they frequently encompass large regions, in some cases...Full Text Available

2010-02-01

145

How and when can one identify hadronic molecules in the baryon spectrum

The development of a computational intelligent tools based on neural network to identify commercial losses or fraud (theft energy), considering information from a database electric utility, is presented.

2009-07-01

146

Contingency Space Analysis: An Alternative Method for Identifying Contingent Relations from Observational Data

A method to identify hadronic molecules in the particle spectrum is reviewed and the conditions for its applicability discussed. Special emphasis is put on the discussion of molecule candidates in the baryon spectrum. (orig.)

2008-03-15

147

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

Descriptive assessment methods have been used in applied settings to identify consequences for problem behavior, thereby aiding in the design of effective treatment programs. Consensus has not been...Full Text Available

2008-01-01

148

A DNA transposon-based approach to validate oncogenic mutations in the mouse

Cancers are highly heterogeneous and contain many passenger and driver mutations. To functionally identify tumor suppressor genes relevant to human cancer, we compiled pools of short harpin...Full Text Available

2008-11-28

149

45 CFR 162.404 - Compliance dates of the implementation of the standard unique health identifier for health care...

Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available

2008-12-16

150

The DIVAD Archaeological Project

...dates of the implementation of the standard unique health identifier for health care providers. 162.404 Section 162.404 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA...

2010-10-01

151

DIGITAL LIBRARIES: IMPACT ON SCIENCE ... - MUSPIN - NASA

... Like other surveys in the Hueco Bolson (Carmichael 1983; Whalen 1977, 1978), the BLM survey identified large concentrations of Pueblo period ...

2011-05-14

152

digital libraries, which was identified as a national challenge in the Information ... The linkages between the many digital libraries and information services are ...

153

Cartridge Cases

Aviation Maintenance Safety Articles, January/February 1990

... reverse aeb 9 nescesmsy amI identify by block number) Provides procedures for evaluating metal, consumable, and combustible cartridge cases. ...

1980-10-21

154

Industrial waste and pollution in Mongolia

... These are abnormal and an indication of NAVAIRINST 13340.3 identifies these laboratories a possible breakdown in the fuel-handling equip- ...

1990-02-01

155

[New cardiotonic agents].

This paper very briefly outlines hazardous waste management issues, including regulations, in Mongolia. Air, water, and soil pollutants are identified and placed in context with climatic, social, and economic circumstances. The primary need identified is technology for the collection and disposal of solid wastes. Municipal waste problems include rapid urbanization and lack of sanitary landfills. Industrial wastes of concern are identified from the mining and leather industries. 4 refs., 2 tabs.

1996-12-31

156

Zonal differences in DNA synthesis activity and cytochrome P450 gene expression in livers of male F344 rats treated with five nongenotoxic carcinogens

The possibilities for therapy in the field of severe cardiac insufficiency have been extended in recent years by the introduction of novel agents endowed with a positive inotropic action. These substances may be arranged in two large classes: sympathomimetic agents and "non sympathomimetic--non digitalis-like" inotropic agents. The stimulant action of noradrenaline, adrenaline and isoproterenol on beta-adrenergic myocardial receptors has been clearly demonstrated but the usefulness of these medicines is limited by their positive chronotropic and arrhythmogenic actions. Dopamine and dobutamine have proved to be very useful in the treatment of patients in intensive care units. However, the exclusively intravenous route of administration limits their importance to the medium or long term. Several compounds, which are active by the oral route, have been the subject of therapeutic trials for the short or medium term. The problems posed by their use result, in the first place, from an ...

1985-12-01

157

Preoperative staging of rectal carcinoma with combined sonography and pelvic computed tomography

Both increased cell proliferation and {open_quotes}altered{close_quotes}CYP gene expression are prominent phenomena associated with liver tumor promotion by nongenotoxic carcinogen treatment. BRDU-labeled parenchymal nuclei were observed primarily in the periportal area of groups of rats, independent of nongenotoxic carcinogen treatment. Treatment with each of the 5 nongenotoxic carcinogens resulted in profound alterations in CPY gene expression at both the transcriptional and translational levels. Expression of CYP1A1, 1A1/2, 3A1, 2B1/2, and 4A immunoproteins demonstrated nongenotoxic carcinogen-specific patterns in both magnitude and zonal distribution. In agreement with the CYP immunoprotein data, treatment with each of the five nongenotoxic carcinogens resulted in a unique composition of mRNAs of CYP2B1, 2B2, 2C6, 2C11, 3A1, 3A2, and 4A1, which were variably increased or decreased relative to the ...

1995-12-31

158

The phase shifts leading to the broadening and shift of spectral lines

The accurate staging of rectal carcinoma is very important for treatment planning. The histological data obtained from surgical specimens of 22 patients with rectal carcinoma were compared with pre-and postoperative endorectal US findings and with preoperative CT results. According to an adapted version of Astler and Coller classification, the different degrees of tumor spread into the rectal wall were represented as follows: stage A: 1 patient; stage B1: 5 patients; stage B2: 6 patients; stage C1: 1 patient; stage C2: 8 patients and stage D: 1 patient. Preoperative staging, based on the overall results of CT and US, was in agreement with histology in 19 of 22 cases. Individual analysis of US and CT results, in comparison with histological data, showed US staging accuracy to be 77.3% (17/22 patients). US accuracy in demonstrating tumor spread into the rectal wall (stages A, B1, C1) was 100% (7/7 ...

1991-01-01

159

The magnetoresonance operation of microwiggler on the piezoelectrics with a strong magnetic guide field

The classical theory of collisional broadening and shift parameters (?, ?) of an isolated spectral line was used to obtain simple analytical formulas for calculating both ? and ?. These formulas were obtained on the assumption that the short range interaction is effective only in the broadening while the long range is effective in the shift of the spectral line. These parameters ? and ? depend on the limiting phase shifts responsible for broadening ?b and shift ??. It was found that the values of ?b and ?? are not equal to each other as was proposed by Weisskopf ?b=??=1. The maximum and average values of ?b (?bmax, ?bav) and ?? (??max, ??av) were obtained by numerical evaluation, using different inverse power potentials. By introducing these parameters into the approximated formulas for ? and ? using Van der Waals and Lennard-Jones potential, it was found that the results of calculations for (? and ?) with different atomic transitions perturbed ...

2009-02-01

160

Susceptible gene single nucleotide polymorphism and hemorrhage risk in patients with brain arteriovenous malformation

We proposed that a new type of the electrostatic microwiggler with a wiggler period (0.1 mm {le}1{sub w}{le}1 mm) and the wiggler field strength (E{sub w}{le} 100 kV/m) can be produced on the surface of a PZT when a high power and high frequency ultrasonic wave travels through a PZT bar. Numerical simulations in the linear and nonlinear gain regime show that a weak microwiggler (E{sub w}100 kV/m,{lambda}{sub w}{approx}100 periods), operating in magnetoresonance with a strong guide field (B{sub o}{approx} 3.6T), can generate a millimeter and submillimeter radiations with medium electronic efficiency of few percents. It is shown that the maximum output power of the compact FEL using the wiggler system generated on the surface of the piezoelectric material may be upto a few Watts with a relatively low energy and low current electron beam (Ew {approx}100 keV and I{sub b}1 mA).

1995-12-31

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

British Library Electronic Table of Contents (United Kingdom)

The relationship between single nucleotide polymorphism (SNP) of interleukin-17 (IL-17A), transforming growth factor @b (TGF-@b), as well as its receptor (TGFR-@b2) and susceptibility to intracerebral hemorrhage in patients with brain arteriovenous malformation (BAVM) was investigated in the present study. A total of 53 patients with BAVM and 120 healthy controls were recruited, all of whom were Han Chinese from South China. There were no statistically significant differences in the IL-17A-197 guanine/adenine (G/A) or TGF-@b1-509 cytosine/thymine (C/T) genotypes or gene frequencies between BAVM patients and controls (p>0.05), but the gene frequency of the TGFR-@b2-875 A/G genotype in patients with BAVM was significantly higher (p<0.05). Furthermore, the frequencies of the G allele of IL-17...

2011-01-01

162

Principe local-global pour les z\\'ero-cycles sur certaines fibrations au-dessus d'une courbe: II

Preparation of ZnO varistors by solution nano-coating technique

We consider an admissible fibration $\\pi:X\\to\\mathbb{P}^1$ over a curve over a number field, of which the generic fiber $X_\\eta$ is geometrically rationally connected. We suppose that there exists a generalized Hilbertian subset $\\textsf{Hil}$ of $\\mathbb{P}^1$, such that the Brauer-Manin obstruction is the only obstruction to the Hasse principle (resp. to the weak approximation) for $X_\\theta(\\theta\\in \\textsf{Hil}).$ We prove that the Brauer-Manin obstruction is the only obstruction to the Hasse principle (resp. to the strong approximation) for zero-cycles of degree 1 on $X$ in the following cases: $(B_1)$ the index of the generic fibre $X_\\eta$ is equal to 1; $(B_2)$ all fibers are geometrically integral. Then, we obtain some similar results for certain fibrations over $\\mathbb{P}^n$. As a consequence, we obtain the following result: let $X$ be a smooth projective geometrically rationally connected variety over a number field ...

2010-01-01

163

Nanocrystallization of soft magnetic Fe-Co-Zr-Cu-B alloys

This paper introduces a new method to produce nano-composite powder for the preparation of high performance ZnO varistors. ZnO particles were coated with Bi{sub 2}O{sub 3}, Sb{sub 2}O{sub 3}, Co{sub 2}O{sub 3}, Cr{sub 2}O{sub 3} and other additives via liquid nano-coating technique. Then the prepared powder was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravity and differential scanning calorimetry (TG-DSC) and particle size distribution. The results showed that the ZnO composite powder is homogeneously coated and ultrafine. The densification, phase composition and microstructure of ZnO varistors was studied by linear shrinkage, X-ray diffraction (XRD) and SEM, respectively. The preliminary electrical parameters of ZnO varistors showed that the breakdown voltage V {sub b} (1 mA/cm{sup 2}) and nonlinear coefficient {alpha} is 5400 V/cm and 50, respectively, much higher than that of ...

2006-06-15

164

Molybdenum complexes of biochemical interest. New coordination complexes of oxomolybdenum(V) with the tridentate ONO donor Schiff bases derived from salicylaldehydes and ethanolamine

In the present study, Fe_4_1Co_4_1 B_1_0Zr_7Cu_1 alloy has been investigated in order to evaluate its thermal stability and structure after heat treatment, as well as the impact of heat treatment on magnetic properties. X-ray diffractometry, differential scanning calorimetry, chemical composition microanalysis, transmission electron microscopy, and magnetic hysteresis loop measurement techniques were employed. The crystallization temperature of the as-quenched alloy is 490"oC (continuous heating at 5 "oC/min). The melt spun ribbon having 27 #mu#m in thickness was annealed for 1 hour at temperatures from 400 to 700 "oC. The alloy after treatment at about 550"oC underwent primary crystallization, with the average size of crystals under 20 nm. This specimen shows the coercive field of 38 A/m, as compared to about 160 A/m reported for a similar alloy (Fe_4_4Co_4_4B_4Zr_7Cu_1) with a similar structure, annealed at 600"oC. (author)

2001-09-23

165

Interactions between organic anions on multiple transporters in Caco-2 cells.

New oxomolybdenum(V) complexes MoOClL (where LH_2 = Schiff base) derived from ethanolamine and salicylaldehyde, 5-chlorosalicylaldehyde, 5-bromosalicylaldehyde, 5-nitrosalicylaldehyde, 3-ethoxysalicylaldehyde and 2-hydroxy-1-naphthaldehyde have been synthesized and characterised by elemental analyses, conductance, molecular weight, i.r. and electronic spectra and magnetic measurements. The Schiff bases behave as dibasic tridentate ONO donor ligands. The complexes are non-electrolytes and dimers. The complexes exhibit subnormal magnetic moments and are involved in antiferromagnetic exchange with S = 0 ground state. The complexes exhibit electronic spectral bands at ca. 13000 and ca. 17000 cm"-"1 due to the transitions dsub(xy)->dsub(xz,yz) ("2B_2->"2E) and dsub(xy)->dsub(x2-y2) ("2B_2->"2B_1), respectively. The #nu#(Mo=O) frequency of the complexes is observed in the 900-970 cm"-"1 region. On the basis of the magnetic susceptibility, ...

1985-01-01

166

Influence of second phase particles on fracture toughness in AZ31 magnesium alloys

In drug development, Caco-2 cells are often employed to study the influence of membrane transporters on drug permeability. The aim of the current study was to characterize permeability and kinetic parameters of selected organic anionic compounds in Caco-2 cells, and to investigate whether the Caco-2 cell line may be used as an overall model to predict interactions on multiple membrane transporters in the intestine. Taurocholic acid (TCA) and estrone-3-sulfate (E(1) S) were used as model substrates. Possible inhibitors studied were TCA, E(1) S, taurolithocholic acid, fluvastatin, and glipizide. The effects of these compounds on initial uptake, apparent permeability, and intracellular end-point accumulations of the probe substrates were studied. Both interactions on apical and basolateral influx transporters were observed. These interactions were proposed to be mediated mainly by the apical sodium-dependent bile acid transporter and the organic solute transporter ?/?, and to less extent ...

2011-05-23

167

Influence of metallurgical factors on corrosion and electrochemical behavior of structural materials

Three kinds of thin AZ31 wrought magnesium alloys sheets were used in order to investigate the influence of the second phase particles on fracture toughness. From the theoretical model, the ratio of {lambda}{sub p}/d{sub p} would be estimated 5 {proportional_to} 6. On the other hand, from the microstructural observation, average particle spacing on each material was sample A: 13.1 {mu}m, sample B: 14.1, and sample C: 12 {mu}. In addition, average particle size on each sample was sample A: 2.1, sample B: 1.9, and sample C: 2.3 {mu}m. Therefore, the ratio of {lambda}{sub p}/d{sub p} calculated from fracture surface observation would be predicted 6 {proportional_to} 7. In comparison with the result of the prediction by theoretical analysis was in good agreement with the result of fracture toughness observation. It was found that the variation in plane-strain fracture toughness on AZ31 were affected by both of particle spacing and particle size. ...

2004-07-01

168

Heat transfer and thermal performance analysis of a surface with hollow rectangular fins

An analysis of the passive films formed on amorphous alloys of the system Fe-10% Cr-5% Mo-P-metalloid and Fe-10% Cr-5% Mo-B-Si revealed that they are more markedly enriched with chromium in silicon-free alloys. In silicon-containing amorphous alloys the passive films were highly enriched with silicon, which occurred in these films in the form of a corrosion product close to SiO_2. As shown by the investigations of a study of the anodic behavior of Fe_4_0Ni_4_0P_1_4B_6 and Fe_4_0Ni_3_8Mo_4B_1_8, phosphorus facilitates the passivation of amorphous alloys by reducing the solution current in the active state and enriching the surface layers of the metal in the form of a black prepassivation film which also contains nickel and iron. The behavior of Fe-Ni amorphous alloys containing only boron as metalloid additive differs little from that of crystalline alloys of similar composition but without the boron. The authors note that in this survey they ...

1986-01-01

169

Genetic organization of Bungarus multicinctus protease inhibitor-like proteins.

An experimental study was conducted to investigate the heat transfer and friction loss characteristics in a horizontal rectangular channel having attachments of hollow rectangular profile fins over one of its heated surface. The Reynolds number based on the flow averaged inlet velocity and the hydraulic diameter, ranged from 3000 to 32,000. The hollow rectangular profile fins in 10cm height and axb=2cmx4cm dimensions with a thickness of 0.2cm were mounted on a heating surface vertically. Reynolds number, fin arrangement and fin pitch in the flow direction were the experimental parameters. Both in-line and staggered fin arrangements were studied for one-fixed spanwise (S{sub x}/a=3) and four different streamwise (S{sub y}/b=1.5, 1.875, 2.5 and 3.75) distances. Correlation equations for Nu, f and thermal performances were determined for fin configurations and the straight channel case without fins. (author)

2006-02-01

170

Further evidence supporting the concurrent influence of aflatoxin and manganese

The structural organization of the genes encoding Bungarus multicinctus protease inhibitor-like proteins (PILPs), PILP-1, PILP-2 and PILP-3, are reported in this study. Unlike PILP-2 and PILP-3, recombinant PILP-1 exhibited inhibitory activity on trypsin. PILP genes and B chain genes shared identical organization with three exons interrupted by two introns in similar positions. On the contrary, intron 1 of these genes had a similar size, a notable variation with the size of intron 2 was observed. It was found that two regions at the second intron of B1 chain and B2 chain genes were absent in that of PILP genes. Noticeably, intronic insertion in the second intron of B chain genes appeared in the promoter region of PILP-1 gene, but not in that of PILP-2 and PILP-3 genes. Comparative analyses of PILP genes and B chain genes showed that the protein-coding regions of the exons are more diverse than introns, except for in the signal peptide domain. ...

2008-03-27

171

Effects of microwaves on the colony-forming capacity of haemopoietic stem cells in mice

Trace elements, including manganese may afford protection from deleterious effects of aflatoxin. Young male Fischer rats received ip injections of aflatoxin B1 (AFB1) in dimethyl sulfoxide (DMSO), 1 mg/kg, 2 mg/kg or 4 mg/kg. Control groups received DMSO ip or no injection. All animals were intubated with 3 microCi of (/sup 54/Mn)-MnCl/sub 2/ 12 hr post-injection. Sacrifice occurred 72 hr after gavage of the radiolabel. All tested levels of AFB1 affected the loss of total body radioactivity. This response was observed within 12 hr when toxin-treated groups excreted almost 4 times more counts than controls. From 12-36 hr following radiolabel administration, AFB1 appeared to enhance excretion; by 72 hr, toxin-treated animals (especially those receiving higher doses) appeared to conserve the metal. Aflatoxicosis manifested itself through reduced body weight gain. The data provide support evidence that Mn and AFB1 biointeract.

1987-04-01

172

EPR, optical, infrared and Raman studies of VO"2"+ ions in polyvinylalcohol films

A suspension of bone marrow cells from femurs of female (CBA . C57B1)F1 mice was exposed to 2450 MHz CW microwaves in a specially designed waveguide exposure system. The temperature of the suspension rose, during exposure to microwaves, from 20/sup 0/C to 45/sup 0/C, and at an interval within 20/sup 0/C to 45/sup 0/C the number of haemopoietic stem cells (CFUs) was determined by the spleen exocolony method. The time of exposure of bone marrow cells to each temperature studied was 20 s. Control suspensions of bone marrow cells were exposed to a water bath temperature. There were no significant effects of the CFUs with the water bath temperature, while after exposure to microwaves the number of spleen colonies was elevated with a nadir at the temperature of 37/sup 0/C. With a microwave-induced increase of the temperature above 41/sup 0/C the number of CFUs in the bone marrow suspension decreased. The increase in the number of colonies was related ...

1987-01-01

173

Deforming the Maxwell-Sim algebra

Electron paramagnetic resonance (EPR), optical, infrared and Raman spectral studies have been carried out on vanadyl ions doped in polyvinylalcohol (PVA) films. The spin-Hamiltonian parameters (g and A) and the molecular orbital coefficients (#beta#_2"*"2 and k) have been evaluated. The values of spin-Hamiltonian parameters confirm that the vanadyl ions are present in PVA films as VO"2"+ molecular ions in an octahedral site with a tetragonal compression (C_4_v). The temperature variation EPR studies reveal that the variation of number of spins with temperature is in accordance with Boltzmann law. It is interesting to observe that the variation of susceptibility with temperature obeys Curie-Weiss law. The FT-IR and FT-Raman spectrum exhibits few bands, which are attributed to O-H, C-H, C-C and C-O groups of stretching and bending vibrations. The optical absorption spectrum exhibits two bands, which are assigned to "2B_2_g->"2B_1_g and ...

2007-01-15

174

Coulomb and photo cross sections for nucleon emission by relativistic heavy ions and application to "4"0Ar on "8"9Y

The Maxwell algebra is a noncentral extension of the Poincare algebra, in which the momentum generators no longer commute, but satisfy [P?,P?]=Z??. The charges Z?? commute with the momenta, and transform tensorially under the action of the angular momentum generators. If one constructs an action for a massive particle, invariant under these symmetries, one finds that it satisfies the equations of motion of a charged particle interacting with a constant electromagnetic field via the Lorentz force. In this paper, we explore the analogous constructions where one starts instead with the ISim subalgebra of Poincare, this being the symmetry algebra of very special relativity. It admits an analogous noncentral extension, and we find that a particle action invariant under this Maxwell-Sim algebra again describes a particle subject to the ordinary Lorentz force. One can also deform the ISim algebra to DISimb, where b is a nontrivial dimensionless parameter. We find that the motion described by ...

2010-09-15

175

Competition of ferromagnetism and superconductivity in Sc3InB

The Coulomg-induced emission of nucleons by relativistic heavy ions is studied with respect to partial cross sections related to the various multipole orders of the electromagnetic field. Since the partial Coulomb cross sections can be factorized into the numbers of virtual photons and the photo cross sections, we first calculate the photo cross sections using the oscillator shell model and 1-particle-1-hole configurations. Then the Coulomb cross sections are obtained by folding the photo cross sections with the numbers of virtual photons. We apply the calculations to the Coulomb scattering of "4"0Ar ions on "8"9Y targets, where experiments at E_l_a_b=1.8 GeV/nucleon were carried out by Mercier et al. The contributions of the various multipole orders are discussed as functions of the projectile energy and the energy range of the emitted nucleons. Also methods for the separation of the most contributing multipole orders are developed. (orig.).

176

BNFL Report Glass Formers Characterization

We present results of electronic structure calculations for the intermetallic perovskite Sc3InB with the full-potential KKR-LDA method. Sc3InB is a very promising candidate for a new superconductor (related to 8 K MgCNi3) and can be regarded as a boron-inserted cubic Sc3In, which is a high-pressure allotropic form of the hexagonal weak ferromagnet Sc3In. We predict that cubic Sc3In can also be magnetic, whereas Sc3InB having large DOS in the vicinity of E F exhibits non-magnetic ground state. Estimation of the electron-phonon coupling for Sc3InB gives 1. Furthermore, the effect of vacancies in Sc3InB1-x and antisite disorder in Sc3(In-B) on critical parameters is also discussed using the KKR-CPA method. All theoretical results support the possibility of the superconductivity onset in Sc3InB. Preliminary experimental measurements established the transition temperature close to 4.5 K, with a very abrupt change in susceptibility and a correlated ...

2006-01-01

177

Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell lines

The objective of this task was to obtain powder property data on candidate glass former materials, sufficient to guide conceptual design and estimate the cost of glass former handling facilities as requested under Part B1 of BNFL Technical and Development Support. Twenty-nine glass forming materials were selected and obtained from vendors for the characterization of their physical properties, durability in caustic solution, and powder flow characteristics. A glass former was selected based on the characterization for each of the ten oxide classes required for Envelope A, B, and C mixtures. Three blends (A, B, and C) were prepared based on formulations provided by Vitreous State Laboratory and evaluated with the same methods employed for the glass formers. The properties obtained are presented in a series of attached Tables. It was determined that five of the ten glass formers, (kyanite, iron oxide, titania, zircon, and zinc oxide) have the ...

2000-07-27

178

British Library Electronic Table of Contents (United Kingdom)

Abstract. Objective: Lapatinib (Tykerb, GW572016), a potent inhibitor of the catalytic activities of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) (ErbB2), inhibits population growth of selected EGFR and HER2 overexpressing cell lines. Previous studies with a small number of cell lines suggest a correlation between overexpression of EGFR and/or HER2 and sensitivity to growth inhibition by lapatinib; however, the precise determinants of lapatinib selectivity for tumour and/or other cells remain unclear. Materials and methods: To clarify the determinants of its selectivity in cultured cells, lapatinib-induced cell population growth inhibition and relative EGFR and HER2 protein expression were quantified in 61 different human tumour cell lines fro...

2007-01-01

179

Analysis of pesticides in dried hops by liquid chromatography-tandem mass spectrometry.

Alteration of the enterohepatic recirculation of bile acids in rats after exposure to ionizing radiation

An analytical method was developed for the determination of eleven agrochemicals [abamectin (as B1a), bifenazate, bifenthrin, carfentrazone-ethyl, cymoxanil, hexythiazox, imidacloprid, mefenoxam, pymetrozine, quinoxyfen, and trifloxystrobin] in dried hops. The method utilized polymeric and NH2 solid phase extraction (SPE) column cleanups and liquid chromatography with mass spectrometry (LC-MS/MS). Method validation and concurrent recoveries from untreated dried hops ranged from 71 to 126% for all compounds over three levels of fortification (0.10, 1.0, and 10.0 ppm). Commercially grown hop samples collected from several field sites had detectable residues of bifenazate, bifenthrin, hexythiazox, and quinoxyfen. The control sample used was free of contamination below the 0.050 ppm level for all agrochemicals of interest. The limit of quantitation and limit of detection for all compounds were 0.10 and 0.050 ppm, respectively. PMID:18593182

2008-07-02

180

Technical area status report for chemical/physical treatment. Volume 2, Appendices

The aim of this work was to study acute alterations of the enterohepatic recirculation (EHR) of bile acids 3 days after an 8-Gy radiation exposure in vivo in the rat by a washout technique. Using this technique in association with HPLC analysis, the EHR of the major individual bile acids was determined in control and irradiated animals. Ex vivo ileal taurocholate absorption was also studied in Ussing chambers. Major hepatic enzyme activities involved in bile acid synthesis were also measured. Measurements of bile acid intestinal content and intestinal absorption efficiency calculation from washout showed reduced intestinal absorption with significant differences from one bile acid to another: absorption of taurocholate and tauromuricholate was decreased, whereas absorption of the more hydrophobic taurochenodeoxycholate was increased, suggesting that intestinal passive diffusion was enhanced, whereas ileal active transport might be reduced. Basal hepatic secretion was increased only for ...

2004-02-01

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181

Nuclear fuel assembly identification using computer vision

These Appendices describe various technologies that may be applicable to the Mixed Waste Treatment Plant (MWTP) Chemical/Physical Treatment System (CPTS). These technologies were identified by the CPTS Technical Support Group (TSG) as potentially applicable to a variety of separation, volume reduction, and decontamination requirements. The purpose was to identify all available and developing technologies, and their characteristics, for subsequent evaluation for specific requirements identified for the CPTS. However, the technologies described herein are not necessarily all inclusive, nor are they necessarily all applicable.

1993-08-01

182

MEG studies of human vision: Retinotopic organization of V1

This report describes an improved method of remotely identifying irradiated nuclear fuel assemblies. The method uses existing in-cell TV cameras to input an image of the notch-coded top of the fuel assemblies into a computer vision system, which then produces the identifying number for that assembly. This system replaces systems that use either a mechanical mechanism to feel the notches or use human operators to locate notches visually. The system was developed for identifying fuel assemblies from the Fast Flux Test Facility (FFTF) and the Clinch River Breeder Reactor, but could be used for other reactor assembly identification, as appropriate.

1985-11-01

183

sUAS Presentation 26June08.ppt

A primary goal of noninvasive studies of human vision is to identify and characterize multiple visual areas in the human brain analogous to those identified in studies of nonhuman primates. By combining functional MEG measurements with images of individual anatomy derived from MRI, the authors hope to determine the location and arrangement of multiple visual areas in human cortex and to probe their functional significance. The authors have identified several different visual areas thus far which appear to be topographically organized. This paper focuses on the retinotopic characterization of the primary visual area (V1) in humans.

1993-12-31

184

Timber Compartment Boundary

Jun 26, 2008 ... NAVAIRINST 13034.1C. ACC/ARC/ NAT IPT/EDT ENGINEERING. OWNER. FLEET. REQUIREMENT. IDENTIFIED. PROGRAM INITIATED ...

185

The skeletal muscle ryanodine receptor identified as a molecular target of[3H] azidodantrolene by photoaffinity labeling

Timber Compartment Boundary This data set identifies the 90 timber compartment boundaries in a 200 square-mile study ... Kawishiwi Ranger Districts, Superior National ...

186

The early phase change Gene in Maize

... 16, 2001 0006-2979 BIORAK v. 40(2) APPLIED LIFE SCIENCES azido

2001-04-01

187

The Physical Attractiveness of Electronic Physician Notes

Recessive mutations of the early phase change (epc) gene in maize affect several aspects of plant development. These mutations were identified initially because of...Full Text Available

2002-01-01

188

The I3I Model; Identifying Cultural Determinants of Information ...

Though notes in electronic medical record systems (EMRs) have advantages, they are often criticized for their unattractive and unprofessional appearance. We sought to identify notes regarded by physicians...Full Text Available

2010-01-01

189

The Financial War on Terrorism: Grading US Strategy for ...

... Information behavior in dynamic group work contexts: Interwoven situational awareness, dense social networks and contested collaboration in ...

2009-06-01

190

Survey of non-prescribed use of antibiotics for children in an urban community in Mongolia

... that operated in Pakistan, Dubai, and throughout the Middle East ... identifies 'funds' as one of eight major terrorist ... techniques, and procedures (TTP). ...

2006-04-15

191

Social, Clinical and Microbiological Differential Characteristics of Tuberculosis among Immigrants in Spain

AbstractObjectiveTo estimate the prevalence and identify the determinants of non-prescription use of antibiotics for children in Mongolia.MethodsA...Full Text Available

2010-12-01

192

Science and technology for industrial ecology

BackgroundTo identify the differential tuberculosis (TB) characteristics within the immigrant population with respect to natives in Spain.Methodology/Principal...Full Text Available

193

Role of Orvosi Hetilap in the development of Hungarian gastroenterology

This paper first discusses the challenge offered by natural and anthropogenic systems in all of their complexity and then indicates some areas of research in which specific scientific and technological needs are identifiable.

1996-07-10

194

Report of the Geostatistical Analysis of High Resolution ...

AIM: To analyze the contribution of Orvosi Hetilap (Hungarian Medical Journal) to the field of gastroenterology.METHODS: All issues of the journal between 1857 and 2008 and identified...Full Text Available

2010-05-14

195

Plasmid-Determined Copper Resistance in Pseudomonas syringae from Impatiens

... The variogram analysis of the high resolution imagery has shown that although more spatial scales have been identified than from the SPOT image ...

1998-05-01

196

Physiologic changes during growth and development.

A strain of Pseudomonas syringae was recently identified as the cause of a new foliar blight of impatiens. The bacterium was resistant to copper compounds, which are used on a variety...Full Text Available

1990-01-01

197

Patient persistence with first-line antiglaucomatous monotherapy

To express growth-related changes in physiologic or other functions in forms usable for kinetic modeling, we are interested in identifying regular relationships that take the form of simple mathematical...Full Text Available

1994-12-01

198

Optimization for Vibration Isolation.

PurposeTo identify the extent of persistence (period of time of continuous therapy with the drug prescribed) of glaucoma patients treated with prostaglandins (latanoprost, bimatoprost,...Full Text Available

2010-01-01

199

Mutations in RNA Binding Protein Gene Cause Familial Dilated Cardiomyopathy

An almost linear optimization problem of importance in vibration isolation has been identified and algorithms were developed to minimize the forced vibrational response of structural systems. The constraints can be either displacements of accelerations. T...

1983-01-01

200

Medical Conditions of Nursing Home Admissions

ObjectivesWe sought to identify a novel gene for dilated cardiomyopathy (DCM).BackgroundDCM is a heritable, genetically...Full Text Available

2009-09-01

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201

Measurement methods for human exposure analysis.

BackgroundAs long-term nursing home care is likely to increase with the aging of the population, identifying chronic medical conditions is of particular interest. Although need factors...Full Text Available

202

High resolution line shapes of weak autoionizing resonances identified through fluorescence from the satellite states of Ar+

The general methods used to complete measurements of human exposures are identified and illustrations are provided for the cases of indirect and direct methods used for exposure analysis. The application...Full Text Available

1995-04-01

203

Factors Linked to Bacterial Vaginosis in Nonpregnant Women

English 1 Jul 1997 [vp.] United States McLaughlin, KW Yenen, O. Samson,

1997-07-16

204

Facilities evaluation report

Objectives. The purposes of this study were to test the hypothesis that vaginal douching is linked to bacterial vaginosis in both symptomatic and asymptomatic women and to identify...Full Text Available

2001-10-01

205

Coping Strategies of Family Members of Hospitalized Psychiatric Patients

The Buried Waste Integrated Demonstration (BWID) is a program of the Department of Energy (DOE) Office of Technology Development whose mission is to evaluate different new and existing technologies and determine how well they address DOE community waste remediation problems. Twenty-three Technical Task Plans (TTPs) have been identified to support this mission during FY-92; 10 of these have identified some support requirements when demonstrations take place. Section 1 of this report describes the tasks supported by BWID, determines if a technical demonstration is proposed, and if so, identifies the support requirements requested by the TTP Principal Investigators. Section 2 of this report is an evaluation identifying facility characteristics of existing Idaho National Engineering Laboratory (INEL) facilities that may be considered for use in BWID technology demonstration activities.

1992-04-01

206

Computer Vision Hardware System for Automating Rough Mills of Furniture Plants

This exploratory research paper investigated the coping strategies of families of hospitalized psychiatric patients and identified their positive and negative coping strategies. In this paper, the coping...Full Text Available

2011-01-01

207

Characterization of a mycovirus associated with the brown discoloration of edible mushroom, Flammulina velutipes

... company. To automate this initial cutup requires a computer vision system that can locate and identify surface defects ... ...

208

BackgroundA mycovirus previously identified in brown discolored fruiting bodies of the cultivated mushroom Flammulina velutipes was characterized. We tentatively...Full Text Available

209

Cartridge Cases.

Biosynthesis and metabolism of salicylic acid.

This report provides procedures for evaluating metal, consumable, and combustible cartridge cases. It identifies supporting tests, facilities, and equipment required. Subtests include weapon and ammunition preparation, initial inspection, ammunition chara...

1980-01-01

210

Biogenesis of the Protein Storage Vacuole Crystalloid

Pathways of salicylic acid (SA) biosynthesis and metabolism in tobacco have been recently identified. SA, an endogenous regulator of disease resistance, is a product of phenylpropanoid metabolism formed...Full Text Available

1995-05-09

211

Alpha-toxin of Staphylococcus aureus.

We identify new organelles associated with the vacuolar system in plant cells. These organelles are defined biochemically by their internal content of three integral membrane proteins: a chimeric reporter...Full Text Available

2000-08-21

212

49 CFR 130.11 - Communication requirements.

Alpha-toxin, the major cytotoxic agent elaborated by Staphylococcus aureus, was the first bacterial exotoxin to be identified as a pore former. The protein is secreted as a single-chain, water-soluble...Full Text Available

1991-12-01

213

Watching Systems in graphs: an extension of Identifying Codes

...identified as oil when the shipment document accurately describes the material as: aviation fuel, diesel fuel, fuel oil, gasoline, jet fuel, kerosene, motor fuel, or...

2010-10-01

214

Sources of toxicity and exposure information for identifying chemicals of high concern to children

We introduce the notion of watching systems in graphs, which is a generalization of that of identifying codes. We give some basic properties of watching systems, an upper bound on the minimum size of a watching system, and results on the graphs which achieve this bound; we also study the cases of the paths and cycles, and give complexity results.

2010-01-01

215

Molecular cloning of the N-terminus of GTBP

Due to the large number of chemicals in commerce without adequate toxicity characterization data, coupled with an ineffective federal policy for chemical management in the United States, many states are grappling with the challenge to identify toxic chemicals that may pose a risk to human health and the environment. Specific populations (e.g., children, elderly) are particularly sensitive to these toxic chemicals. In 2008, the Children's Safe Product Act (CSPA) was passed in Washington State. The CSPA included specific requirements to identify High Priority Chemicals (HPCs) and Chemicals of High Concern to Children (CHCCs). To implement this legislation, a methodology was developed to identify HPCs from authoritative scientific and regulatory sources on the basis of toxicity criteria. Another set of chemicals of concern was then identified from authoritative sources, based on their potential exposure to ...

2010-11-01

216

Identifying the Key Weaknesses in Network Security at Colleges.

Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5{prime} terminus, allowing definition of the entire coding region. Several polymorphisms within the 5{prime} end were identified and are presented. 13 refs., 1 fig.

1996-02-01

217

Identification of unusual Campylobacter-like isolates from poultry products as Helicobacter pullorum

A new study identifies and ranks the 10 security gaps responsible for most outsider attacks on college computer networks. The list is intended to help campus system administrators establish priorities as they work to increase security. One network security expert urges that institutions utilize multiple security layers. (DB)

1999-12-01

218

DEFF Research Database (Denmark)

Twenty-six unclassified Campylobacter-like strains previously isolated from 15 chicken carcasses and caecal contents, together with two more strains isolated from chicken faeces on a different occasion, were identified as Helicobacter pullorum using various phenotypic identification methods. API Campy identification kits and a 16-test identification scheme developed for campylobacters failed to identify these bacteria, or identified them as Campylobacter spp. Eighteen strains (including the two isolated on a different occasion) were chosen for examination using a more comprehensive probabilistic identification scheme. Using this method, 14 of the 18 strains were identified as H. pullorum with ID scores > 95%; two strains were also identified as H. pullorum with lower ID scores. Of the remaining two strains, one was not identified with this scheme and the ...

1998-01-01

219

Epidemiological and clinical features of 1,149 persons with Lyme disease identified by laboratory-based surveillance in Connecticut.

Design study of copper toroidal field coils with bow shaping, demountable sliding joints, and active liquid-nitrogen cooling

Laboratory-based surveillance of Lyme disease in Connecticut during 1984 and 1985 identified 3,098 persons with suspected Lyme disease; 1,149 were defined as cases. Lyme disease incidence in Connecticut...Full Text Available

1989-05-01

220

CFCC radiant burner assessment. Final report, April 1, 1992--July 31, 1994

The motivation for this design study has been to identify magnet designs for useful magnetic fusion experiments which minimize capital cost. Some possibly useful novel design features have been identified. 5 refs., 6 figs., 3 tabs.

1996-06-16

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221

Resource Management plan for the Oak Ridge Reservation. Volume 28, Wetlands on the Oak Ridge Reservation

The objective of this work was to identify methods of improving the performance of gas-fired radiant burners through the use of Continuous Fiber Ceramic Composites (CFCCs). Methods have been identified to improve the price and performance characteristics of the porous surface burner. Results are described.

1994-11-01

222

Resource Management plan for the Oak Ridge Reservation

A survey of wetlands on the Oak Ridge Reservation (ORR) was conducted in 1990. Wetlands occurring on ORR were identified using National Wetlands Inventory (NWI) maps and field surveys. More than 120 sites were visited and 90 wetlands were identified. Wetland types on ORR included emergent communities in shallow embayments on reservoirs, emergent and aquatic communities in ponds, forested wetland on low ground along major creeks, and wet meadows and marshes associated with streams and seeps. Vascular plant species occurring on sites visited were inventoried, and 57 species were added to the checklist of vascular plants on ORR. Three species listed as rare in Tennessee were discovered on ORR during the wetlands survey. The survey provided an intensive ground truth of the wetlands identified by NWI and offered an indication of wetlands that the NWI remote sensing techniques did not detect.

1991-12-01

223

Plan for addressing issues relating to oil shale plant siting

A survey of wetlands on the Oak Ridge Reservation (ORR) was conducted in 1990. Wetlands occurring on ORR were identified using National Wetlands Inventory (NWI) maps and field surveys. More than 120 sites were visited and 90 wetlands were identified. Wetland types on ORR included emergent communities in shallow embayments on reservoirs, emergent and aquatic communities in ponds, forested wetland on low ground along major creeks, and wet meadows and marshes associated with streams and seeps. Vascular plant species occurring on sites visited were inventoried, and 57 species were added to the checklist of vascular plants on ORR. Three species listed as rare in Tennessee were discovered on ORR during the wetlands survey. The survey provided an intensive ground truth of the wetlands identified by NWI and offered an indication of wetlands that the NWI remote sensing techniques did not detect.

1991-12-01

224

Identification of optimum sites for power system stabilizer applications

The Western Research Institute plan for addressing oil shale plant siting methodology calls for identifying the available resources such as oil shale, water, topography and transportation, and human resources. Restrictions on development are addressed: land ownership, land use, water rights, environment, socioeconomics, culture, health and safety, and other institutional restrictions. Descriptions of the technologies for development of oil shale resources are included. The impacts of oil shale development on the environment, socioeconomic structure, water availability, and other conditions are discussed. Finally, the Western Research Institute plan proposes to integrate these topics to develop a flow chart for oil shale plant siting. Western Research Institute has (1) identified relative topics for shale oil plant siting, (2) surveyed both published and unpublished information, and (3) identified data gaps and research ...

1987-09-01

225

Environmental analysis of endocrine disrupting effects from hydrocarbon contaminants in the ecosystem. 1997 annual progress report

Many existing methods of identifying the optimum sites for installing power system stabilizers (PSSs) in multi-machine systems are restricted to the sequential PSS application, which considers the enhancement of damping of just one critical electromechanical mode at a time; the eigenstructure analysis of the open-loop system, which does not take the control matrix (i.e., the B matrix in the linearized model x = Ax + Bu for power systems) into consideration. This paper presents a method of identifying the optimum sites for installing power system stabilizers. The advantages of this method are: it can identify the optimum sites for installing PSSs so that several electrochemical modes are damped out simultaneously; it takes both the eigenstructure of the open-loop system and the control matrix into consideration.

1990-11-01

226

DNA barcoding as a tool for species identification in three forensic wildlife cases in South Africa

'The overall objective of the basic research grant is to characterize the potential of common hydrocarbon contaminants in ecosystems to act as endocrine disruptors. The three major lines of research include (1) a biotechnology based screening system to identify potential hormone mimics and antagonists; (2) an animal screening system to identify biomarkers of endocrine effects. and (3) a literature review to identify compounds at a variety of DOE sites that need to be examined for endocrine disrupting effects. By relating results obtained from this research project to contamination problems at various DOE sites. CBR will provide data and information on endocrine disrupting contaminants to DOE for consideration in risk analyses for determining clean-up levels and priorities needed at the sites.'

1997-01-01

227

British Library Electronic Table of Contents (United Kingdom)

Poaching of wildlife animals for subsistence and commercial purposes has lead to population declines in Africa. In forensic cases, a need exists to identify the species of origin of carcasses, meat or blood. In the study presented here, the mitochondrial COI gene was sequenced to determine the species of unknown samples in three suspect South African forensic wildlife cases. In two cases the unknown samples were identified as originating from domestic cattle (Bos taurus) and in the third case the sample was identified as common reedbuck (Redunca arundinum). This is the first report of the COI sequence of common reedbuck. The study highlights the need for accurate wildlife reference material from each country in order to convict wildlife cases.

2011-01-01

228

Assessment of coal gasification/hot gas cleanup based advanced gas turbine systems: Greenfield assessment. Final report

Assessment of coal gasification/hot gas cleanup based advanced gas turbine systems: Greenfield assessment

Both the KRW fluidized-bed gasifier and the transport gasifier case studies were used for this assessment. The transport technology is a high-velocity circulating fluidized-bed reactor currently under development by The M.W. Kellogg Company. In the earlier assessment, seven design concepts or cases were identified; a process design was developed; major equipment items were identified; estimates of capital cost, operation and maintenance cost, and cost of electricity were developed; reliability was predicted; and development issues were identified for six studies. Three of the most probable cases were further evaluated for a Greenfield assessment in this report to adequately determine all costs independent of facilities at Plant Wansley.

1991-12-01

229

Application of remote sensing to identify coalfires in the Raniganj Coalbelt, India

Both the KRW fluidized-bed gasifier and the transport gasifier case studies were used for this assessment. The transport technology is a high-velocity circulating fluidized-bed reactor currently under development by The M.W. Kellogg Company. In the earlier assessment, seven design concepts or cases were identified; a process design was developed; major equipment items were identified; estimates of capital cost, operation and maintenance cost, and cost of electricity were developed; reliability was predicted; and development issues were identified for six studies. Three of the most probable cases were further evaluated for a Greenfield assessment in this report to adequately determine all costs independent of facilities at Plant Wansley.

1991-12-01

230

British Library Electronic Table of Contents (United Kingdom)

Raniganj and Jharia regions together have been for long the single largest coal supplier in India, now contributing about a quarter of the total output in the country. Numerous reasons such as improper mining techniques and policy, as well as unauthorized mining caused surface and subsurface coalfires in these areas. These coalfires burn millions of tonnes of valuable coal resources, creating severe environmental problems and posing enormous operational difficulties of mining. After first use of remote sensing as a tool to identify coalfires in 1960s, with the time, the efficiency of remote sensing to identify and monitoring coalfires has been well established by several researchers. With the knowledge of local geological setting and density sliced surface temperature image the spatial dis...

2006-01-01

231

Analysis of organic acids in the pyrohydrolysis distillate of (U,Pu) mixed carbide fuel by ion chromatography

An evaluation of the UK skills base for toxicologists and ecotoxicologists, with focus on current and future requirements, particularly with regard to the skills required for hazard assessment of chemical substances including nanomaterials

The study reports the identification of different organic acids that are formed during the pyrohydrolysis of mixed carbide of uranium and plutonium using ion chromatography (IC). The identification of organic acids present in the pyrohydrolysis distillate is required to carry out interference free analysis of Cl and F. The study describes three stage isocratic separations with NaOH eluents having concentrations 2 mM, 10 mM and 50 mM respectively in order to separate and identify both aliphatic and aromatic acids. The present investigation identified formic, acetic, propionic, butyric, tartaric and oxalic acids in the distillate, however, aromatic acids could not be identified. (author)

2011-02-22

232

Environmental Research Database

Objectives1. To establish the present capacity and capability across all the sectors within the UK for - a) Undertaking research in the areas of toxicology and ecotoxicology and environmental hazard and risk assessment work on chemical subtances including emerging containments (e.g. enginerred nanomaterials); and b) Applying these skills in the policy and regulatory context. 2) The range of chemicals involved should include pharmaceutical and medical products, crop protection agents, biocides, vet [continued...]DescriptionThe aim of this project is to identify the current status of the scientific community, areas of expertise, and identify the gaps in skills, knowledge or recruitment. The project will use a questionnaire approach to obtain this information for all sectors of the business community. The analysis will identify the gaps in provision, and areas where investment is needed in future training and/or recruitment.

2009-01-15

233

misty somites, a maternal effect gene identified by transposon-mediated insertional mutagenesis in zebrafish that is essential for the somite boundary maintenance

aHUS caused by complement dysregulation: new therapies on the horizon

Somite boundary formation is crucial for segmentation of vertebrate somites and vertebrae and skeletal muscle morphogenesis. Previously, we developed a Tol2 transposon-mediated...Full Text Available

2008-04-15

234

Workshop to identify critical windows of exposure for children's health: neurobehavioral work group summary.

Atypical hemolytic uremic syndrome (aHUS) is a heterogeneous disease that is caused by defective complement regulation in over 50% of cases. Mutations have been identified in genes encoding both complement...Full Text Available

2011-01-01

235

Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection

This paper summarizes the deliberations of a work group charged with addressing specific questions relevant to risk estimation in developmental neurotoxicology. We focused on eight questions. a) Does...Full Text Available

2000-06-01

236

Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans

The protozoan parasite Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical infection that affects millions of people in the Americas. Current chemotherapy...Full Text Available

237

Validation of the treatment identification strategy of the HEDIS addiction quality measures: concordance with medical record review

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers...Full Text Available

2011-04-01

238

Using microarrays to identify positional candidate genes for QTL: the case study of ACTH response in pigs

BackgroundStrategies to accurately identify the occurrence of specific health care events in administrative data is central to many quality improvement and research efforts. Many...Full Text Available

239

Using Regulatory and Epistatic Networks to Extend the Findings of a Genome Scan: Identifying the Gene Drivers of Pigmentation in Merino Sheep

BackgroundMicroarray studies can supplement QTL studies by suggesting potential candidate genes in the QTL regions, which by themselves are too large to provide a limited selection...Full Text Available

240

Use of solid state nuclear track detectors for radon concentration measurements indoors

Extending genome wide association analysis by the inclusion of gene expression data may assist in the dissection of complex traits. We examined piebald, a pigmentation phenotype in both human and Merino...Full Text Available

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241

Uptake of injected 125I-ricin by rat liver in vivo. Subcellular distribution and characterization of the internalized ligand.

An indoor radioactive survey is being conducted in an Italian district. Preliminary results identified a zone with significant radioactive levels, in which a new specific survey has been planned. In this paper attention is dedicated mainly to radon measurement technique and results.

242

Tumor-derived extracellular mutations of PTPRT/PTP? are deficient in cell adhesion

Subcellular-fractionation techniques were used to characterize the endocytic pathway followed by ricin in rat liver in vivo and tentatively identify the site(s) at which the ricin interchain disulphide...Full Text Available

1992-05-15

243

Treatment with Selective Serotonin Reuptake Inhibitors and Mirtapazine Results in Differential Brain Activation by Visual Erotic Stimuli in Patients with Major Depressive Disorder

Receptor protein tyrosine phosphatase T (PTPRT/PTPρ) is frequently mutated in human cancers including colon, lung, gastric and skin cancers. More than half of the identified tumor-derived...Full Text Available

2008-07-01

244

Trauma service cost: the real story.

ObjectiveThe objective of this study was to identify patterns of brain activation elicited by erotic visual stimuli in patients treated with either Selective Serotonin Reuptake Inhibitors...Full Text Available

2009-06-01

245

The feasibility of using pattern recognition software to measure the influence of computer use on the consultation

OBJECTIVE: The objective was to define and characterize the costs associated with trauma care at a level I trauma center. Once the costs were identified, attending physician-led teams were designed...Full Text Available

1998-05-01

246

The Relationship between Leishmaniasis and AIDS: the Second 10 Years

BackgroundA key feature of a good general practice consultation is that it is patient-centred. A number of verbal and non-verbal behaviours have been identified as important to establish...Full Text Available

247

The Mitochondrial Isovaleryl-Coenzyme A Dehydrogenase of Arabidopsis Oxidizes Intermediates of Leucine and Valine Catabolism1

Summary: To date, most Leishmania and human immunodeficiency virus (HIV) coinfection cases reported to WHO come from Southern Europe. Up to the year 2001, nearly 2,000 cases of coinfection were identified,...Full Text Available

2008-04-01

248

The Challenge of Basic Education for All.

We recently identified a cDNA encoding a putative isovaleryl-coenzyme A (CoA) dehydrogenase in Arabidopsis (AtIVD). In animals, this homotetrameric enzyme is located in mitochondria and catalyzes the...Full Text Available

2001-06-01

249

The Arabidopsis ref2 Mutant Is Defective in the Gene Encoding CYP83A1 and Shows Both Phenylpropanoid and Glucosinolate Phenotypes

Clarifies the concept of universal basic education. Highlights the need for performance criteria and ways to measure literacy attainment. Identifies issues related to improving primary education, seeing adult literacy as its necessary complement. Underscores the substantial resources required to achieve universal basic education. (CH)

1988-12-01

250

The Anopheles gambiae glutathione transferase supergene family: annotation, phylogeny and expression profiles

The Arabidopsis ref2 mutant was identified in a screen for plants having altered fluorescence under UV light. Characterization of the ref2 mutants showed that they...Full Text Available

2003-01-01

251

Terminal-differential algorithm for identification of local non homogeneity in article

BackgroundTwenty-eight genes putatively encoding cytosolic glutathione transferases have been identified in the Anopheles gambiae genome. We manually annotated these...Full Text Available

252

Tachyons and the instability of physical systems

Terminal-differential algorithm for identification of local nonhomogeneities in items under control is developed on the basis of measurements of X-ray or gamma-radiation weakening. The algorithm may be applied by developing radiation schemes of nondestructive control, identifying inadmissible inclusions in the object under study

253

Syk Tyrosine Kinase Acts as a Pancreatic Adenocarcinoma Tumor Suppressor by Regulating Cellular Growth and Invasion

The problem on the ratio between the instability of physical systems and tachyons is discussed. It is shown that the tachyons participation in the real physical process of the system rearranging does not contradict any principles. It is noted that the tachyons constitute the most significant element of the systems, identifying the instability relative to the phase transition into the stable state.

254

Swift Science Center - HEASARC - NASA

We have identified the nonreceptor tyrosine kinase syk as a marker of differentiation/tumor suppressor in pancreatic ductal adenocarcinoma (PDAC). Syk expression is lost in poorly differentiated PDAC...Full Text Available

2009-12-01

255

Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection

Apr 20, 2009 ... "YY" is the 2-digit filter identifier .... In our example you can see a point- like optical/UV source in each of the filters at the ... The "sigma" paramter gives the detection threshold in terms of Gaussian sigma. ...

256

Survival of HIV-Infected Adolescents on Antiretroviral Therapy in Uganda: Findings from a Nationally Representative Cohort in Uganda

BackgroundXenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study,...Full Text Available

257

Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid

BackgroundAdolescents have been identified as a high-risk group for poor adherence to and defaulting from combination antiretroviral therapy (cART) care. However, data on outcomes...Full Text Available

258

Sugarcane pests and their management

Surfactant protein A (SP-A), first identified as a component of the lung surfactant system, is now recognized to be an important contributor to host defence mechanisms. SP-A can facilitate phagocytosis...Full Text Available

2004-01-01

259

Study on the transient piping vibration of power plant. Secondary piping system of Wolsung 1 unit.

This book chapter discusses sugarcane culture and history, describes arthropod biologies and injury, and identifies sugarcane pest management factors to consider for people interested in commercial sugarcane production. Arthropod groups include 10 orders and 40 families. Sugarcane pest management ...

260

Statistical methods for the blood beryllium lymphocyte proliferation test.

In order to maintain a safe operation and availability of generating facilities, qualitative and quantitative assessment of piping vibration was performed vibration sources and damages of piping support was identified on the second piping system of Wolsun...

1996-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

261

Some design considerations for solar-powered aircraft

The blood beryllium lymphocyte proliferation test (BeLPT) is a modification of the standard lymphocyte proliferation test that is used to identify persons who may have chronic beryllium disease. A major...Full Text Available

1996-10-01

262

Sequential Molecular and Cellular Events during Neoplastic Progression: A Mouse Syngeneic Ovarian Cancer Model1

Performance and operating characteristics are presented for a solar powered aircraft intended to remain aloft for long periods. The critical technologies which limit the performance are identified. By using the techniques presented, the effects of variation in the system parameters are studied. Practical design consideration are discussed.

1980-06-01

263

Self-Medication: Initial Treatments Used by Patients Seen in an Ophthalmologic Emergency Room

AbstractStudies performed to identify early events of ovarian cancer and to establish molecular markers to support early detection and development of chemopreventive regimens have been...Full Text Available

2005-10-01

264

Selection of Inhibitor-Resistant Viral Potassium Channels Identifies a Selectivity Filter Site that Affects Barium and Amantadine Block

OJECTIVEThis study seeks to identify practices of self-medication in the treatment of ocular emergencies. We examine patients’ use of both homemade preparations and manufactured...Full Text Available

2009-08-01

265

Retrospective identification and characterization of mild cognitive impairment from a prospective population cohort

BackgroundUnderstanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function...Full Text Available

266

Retention, Learning by Doing, and Performance in Emergency Medical Services

ObjectivesMild Cognitive Impairment (MCI) case-finding criteria have low specificity in general population studies. The present study retrospectively identifies cases...Full Text Available

2010-08-01

267

Repeated tumor oximetry to identify therapeutic window during metronomic cyclophosphamide treatment of 9L gliomas

ObjectivesTo examine the strength of the volume–outcome relationship among paramedics, a group of providers that has not been previously studied in this context. By identifying...Full Text Available

2009-06-01

268

Renewable energy and the ODA energy efficient strategy

Malignant gliomas are aggressive and angiogenic tumors with high VEGF content. Consequently, approaches such as metronomic chemotherapy, which have an antiangiogenic effect, are being investigated....Full Text Available

2011-07-01

269

Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice

The energy strategy of the UK Overseas Development Administration is outlined with specific emphasis on energy efficiency and renewable energies. Based on 29 case studies concerning projects and programmes in both developed and developing countries, critical success factors for renewable energy projects are identified. UK)

1995-12-31

270

Reduced Accumulation of ABA during Water Stress in a Molybdenum Cofactor Mutant of Barley ¹

Sensory neurons in aging mammals undergo changes in anatomy, physiology and gene expression that correlate with reduced sensory perception. In this study we compared young and aged mice to identify...Full Text Available

2006-06-01

271

Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545

A barley (Hordeum vulgare L.) mutant (Az34) has been identified with low basal levels of abscisic acid (ABA) and with reduced capacity for producing ABA in response to water stress....Full Text Available

1989-06-01

272

Radiographic monitoring of incidental abdominal aortic aneurysms: a retrospective population-based cohort study

The aspirin esterase activity of human plasma is due to butyrylcholinesterase and albumin. Our goal was to identify the amino acid residues involved in the aspirin esterase activity of albumin....Full Text Available

2010-03-01

273

Queensland resources of black coal, December 1988

BackgroundAn abdominal aortic aneurysm (AAA) that is identified when the abdomen is imaged for some other reason is known as an incidental AAA. No population-based studies have...Full Text Available

274

Quality assessment of reporting of randomization, allocation concealment, and blinding in traditional chinese medicine RCTs: A review of 3159 RCTs identified from 260 systematic reviews

This assessment of Queensland's resources of black coal has been prepared by the Coal and Oil Shale Resources Assessment and Development Subprogram, Queensland Department of Mines, in accordance with the 'Code for Reporting of Identified Coal Resources and Reserves'.

1989-01-01

275

Psychology and health: contributions of psychology to the improvement of health and health care

BackgroundRandomized controlled trials (RCTs) which are of poor quality tend to exaggerate the effect estimate and lead to wrong or misleading conclusions. The aim of this study...Full Text Available

276

Proteomic approach with LCMS-IT-TOF identified an increase of Rab33B after transient focal cerebral ischemia in mice

Psychology as both a science and a profession has been closely identified with other disciplines in the broad field of health since the turn of the present century. Recent advances in health care have...Full Text Available

1987-01-01

277

Proteome of human colon cancer stem cells: A comparative analysis

BackgroundSeveral proteins are known to be markedly expressed in the brain during cerebral ischemia; however, the changes in protein profiles within the ischemic brain after an ischemic...Full Text Available

278

Prosthesis use in persons with lower- and upper-limb amputation

AIM: To isolate and identify the biological characteristics of human colon cancer stem cells (SW1116 cells) and further study their proteome.METHODS: SW1116 cells were isolated and cultured with...Full Text Available

2011-03-14

279

Proline Betaine Accumulation and Metabolism in Alfalfa Plants under Sodium Chloride Stress. Exploring Its Compartmentalization in Nodules1

This study identified clinical (e.g., etiology) and demographic factors related to prosthesis use in persons with upper- and lower-limb amputation (ULA and LLA, respectively) and the effect...Full Text Available

2008-01-01

280

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety

The osmoprotectant Pro betaine is the main betaine identified in alfalfa (Medicago sativa). We have investigated the long-term responses of nodulated alfalfa plants to salt stress,...Full Text Available

2004-07-01

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281

Predictors of disability in a longitudinal sample of patients with rheumatoid arthritis.

Preterm birth is the leading cause of neonatal mortality and morbidity and long-term disability of non-anomalous infants. Previous studies have identified a prior early spontaneous preterm birth as...Full Text Available

2009-01-01

282

Predictors for presence and abundance of small mammals in households of villages endemic for commensal rodent plague in Yunnan Province, China

Information from the Health Assessment Questionnaire (HAQ) is used to identify which variables measured in 1981 successfully predict the severity of disease in 1989 and the eight year change in severity...Full Text Available

1992-05-01

283

Predicting outcome of rethoracotomy for suspected pericardial tamponade following cardio-thoracic surgery in the intensive care unit

BackgroundNinety-one rodent plague epidemics have occurred in Lianghe county, Yunnan Province, China, between 1990 and 2006. This study aimed to identify predictors for the presence...Full Text Available

284

Potentially Inappropriate Prescribing of Benzodiazepines for Older Adults and Risk of Falls During a Hospital Stay: A Descriptive Study

ObjectivesPericardial tamponade after cardiac surgery is difficult to diagnose, thereby rendering timing of rethoracotomy hard. We aimed at identifying factors predicting the outcome...Full Text Available

285

Polyantigenic Interferon-? Responses Are Associated with Protection from TB among HIV-Infected Adults with Childhood BCG Immunization

Background:Falls have been identified as a potential adverse event associated with the administration of psychotropic medications to older patients.Objective:The...Full Text Available

2009-07-01

286

Phosphorylated PmrA Interacts with the Promoter Region of ugd in Salmonella enterica Serovar Typhimurium

BackgroundSurrogate immunologic markers for natural and vaccine-mediated protection against tuberculosis (TB) have not been identified.MethodsHIV-infected...Full Text Available

287

Patient-Care Practices Associated With an Increased Prevalence Of Hepatitis C Virus Infection among Chronic Hemodialysis Patients

The Salmonella PmrA-PmrB system controls the expression of genes necessary for polymyxin B resistance. Four loci were previously identified as part of the regulon, and interaction of...Full Text Available

2000-07-01

288

Past, present, and future of mutagens in cooked foods.

ObjectiveTo identify patient-care practices related to an increased prevalence of hepatitis C virus (HCV) infection among chronic hemodialysis patients.Full Text Available

2011-05-01

289

Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.

Mutation assay with Salmonella typhimurium enabled us to detect various types of mutagens in cooked foods. A series of mutagenic heterocyclic amines has been isolated and identified in broiled fish...Full Text Available

1986-08-01

290

Online quasi-continuous measurement of organic acids in the atmosphere

In an earlier report, we used differential cloning to identify genes that might be critical in controlling arterial neointima formation (Giachelli, C., N. Bae, D. Lombardi, M. Majesky, and S. Schwartz....Full Text Available

1993-10-01

291

Oil palm (Elaeis guineensis Jacq.) tissue culture ESTs: Identifying genes associated with callogenesis and embryogenesis

The concentration of some organic acids in the atmosphere was determined using a wet effluent diffusion denuder-aerosol collector coupled with Ion Chromatography. Three organic acids and four inorganic anions were identified and quantified in the air sample, taken from the backyard of PSI. (author)

2002-03-01

292

Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression

BackgroundOil palm (Elaeis guineensis Jacq.) is one of the most important oil bearing crops in the world. However, genetic improvement of oil palm through conventional...Full Text Available

293

Novel high-throughput screening system for identifying STAT3-SH2 antagonists

Noncoding RNAs play important roles in various aspects of gene regulation. We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGCs), a subnuclear domain...Full Text Available

2010-12-01

294

Nitric Oxide Emissions from Soybean Leaves during in Vivo Nitrate Reductase Assays ¹

Constitutive activation of the oncogenic transcription factor STAT3 frequently occurs in various human malignancies. STAT3 activation involves dimerization via intermolecular pTyr-SH2 interaction. Thus, antagonizing this interaction is a feasible approach to inhibit STAT3 activation for cancer therapy. In order to identify selective STAT3 inhibitors, we developed a biochemical HTS system based on AlphaScreen technology, which measures the abilities of test compounds to antagonize pTyr-SH2 interactions. We screened our chemical libraries using this system and identified 5,15-diphenylporphyrin (5,15-DPP) as a selective STAT3-SH2 antagonist. Selective inhibition of STAT3 nuclear translocation and DNA biding activity was observed in cells treated with 5,15-DPP. IL-6-dependent dimerization of STAT3, c-myc promoter binding and c-myc protein expression were all suppressed by 5,15-DPP, whereas no decrement in either expression or phosphorylation level ...

2009-03-13

295

Mutation analysis of 272 Spanish families affected by autosomal recessive retinitis pigmentosa using a genotyping microarray

Recent work identified acetaldehyde oxime as the predominant product purged by inert gases from anaerobic in vivo nitrate reductase (NR) assays of soybean (Glycine max...Full Text Available

1987-09-01

296

Mutation Spectrum of EYS in Spanish Patients with Autosomal Recessive Retinitis Pigmentosa

PurposeRetinitis pigmentosa (RP) is a genetically heterogeneous disorder characterized by progressive loss of vision. The aim of this study was to identify the causative mutations...Full Text Available

297

Multicenter Case-Control Study on Restless Legs Syndrome in Multiple Sclerosis: the REMS Study

Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal dystrophies characterised ultimately by the loss of photoreceptor cells. We have recently identified a new gene (EYS) encoding...Full Text Available

2010-11-01

298

Morphology of inhibitory and excitatory interneurons in superficial laminae of the rat dorsal horn

Study objectives:To verify the existence of a symptomatic form of restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and to identify possible associated risk factors.Design:Prospective,...Full Text Available

2008-07-01

299

Monitoring the Simultaneous Presentation of Spatialized Speech Signals in a Virtual Acoustic Environment.

If we are to stand any chance of understanding the circuitry of the superficial dorsal horn, it is imperative that we can identify which classes of interneuron are excitatory and which are inhibitory....Full Text Available

2007-10-15

300

Monitoring of NK-Cell Immunotherapy using non-invasive Imaging Modalities

The effect of spatial auditory information on a listener's ability to detect, identify, and monitor multiple simultaneous speech signals was evaluated using virtual audio technology. Factorial combinations of three variables - the number of localized spee...

1998-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Molecular cloning and nucleotide sequence of the beta-lytic protease gene from Achromobacter lyticus.

Cancer immunotherapies can be guided by cellular imaging techniques, which can identify the presence or absence of immune-cell accumulation in the tumor tissue in-vivo and in real time. This...Full Text Available

2010-08-01

302

Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans

Two bacteriolytic enzymes secreted by Achromobacter lyticus M497-1 were purified and identified as being very similar (considering their amino acid composition and N-terminal sequence) to alpha- and...Full Text Available

1990-11-01

303

Misclassification of Patients with Spinocerebellar Ataxia as Having Psychogenic Postural Instability Based on Computerized Dynamic Posturography

The fungus Cryptococcus neoformans is a major cause of morbidity and mortality in patients with impaired CD4⁺ T cell function, particularly those with AIDS. To identify...Full Text Available

2001-08-28

304

Milk fever and alert downer cows: Does hypophosphatemia affect the treatment response?

Specific criteria have been developed based on computerized dynamic posturography (CDP) to assist clinicians in identifying patients with psychogenic balance problems (Cyr and Cevette, Full Text Available

305

Microsoft Word - ~4679716.doc

The purpose of this prospective cohort study was to identify factors that place a dairy cow with uncomplicated milk fever (MF) at significant risk of becoming an alert downer cow (ADC) and to verify...Full Text Available

2007-05-01

306

Measurement of Sexual Functioning After Spinal Cord Injury: Preferred Instruments

UNEP will provide in the first CPR quarterly report of 2011 the financial statements for 2010. ...for assessing and rating programme performance UNEP to work with the CPR to identify better ways of streamlining reporting requirements ...in 2011 to achieve the ratios requested by the CPR dependent on receipt of contributions originally planned for the

307

Mapping neuropeptide expression by mass spectrometry in single dissected identified neurons from the dorsal ganglion of the nematode Ascaris suum

Background/Objective:To determine the utility of certain instruments to assess sexuality and fertility after SCI, an expert panel identified key areas to study and evaluated...Full Text Available

2009-06-01

308

We have developed a method for dissecting single neurons from the nematode Ascaris suum, in order to determine their peptide content by mass spectrometry (MS). In this paper,...Full Text Available

2010-07-21

309

Manganese

MFR, a Putative Receptor Mediating the Fusion of Macrophages

Sources of manganese are identified. Uptake and distribution of manganese in plants and man are discussed, and the role of manganese in metabolism is described. The epidemiology of manganese toxicity is outlined, permissible air concentrations are listed, and the symptoms of manganese toxicity and deficiency are described. 555 references, 32 tables.

1973-01-01

310

Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage Fc?RI, Fc?RIII, and Fc?RIV

We had previously identified a macrophage surface protein whose expression is highly induced, transient, and specific, as it is restricted to actively fusing macrophages in vitro and in vivo. This protein...Full Text Available

1998-11-01

311

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

Despite the demonstrated clinical efficacy of CD20 monoclonal antibody (mAb) for lymphoma therapy, the in vivo mechanisms of tumor depletion remain controversial and variable. To identify the molecular...Full Text Available

2008-08-15

312

Light-Dependent Regulation of Cyanobacterial Phytochrome Expression

Recently, genome-wide association studies (GWAS) have linked the human LIN28B locus to height and timing of menarche [1-Full Text Available

2010-07-01

313

Life history plasticity after attaining a dietary threshold for reproduction is associated with protein storage in flesh flies

A histidine kinase protein (Cph1) with sequence homology and spectral characteristics very similar to those of the plant phytochrome has been recently identified in the cyanobacterium Synechocystis...Full Text Available

2000-01-01

314

Lameness, Activity Time-Budgets, and Estrus Expression in Dairy Cattle

SummaryBody condition affects the timing and magnitude of life history transitions. Therefore, identifying proximate mechanisms...Full Text Available

2008-12-01

315

Laboratory Evaluation of Base Materials for Neutralization of the Contaminated Aquifer at the F-Area Seepage Basins

The aim of the present study was to identify specific behavioral patterns that contribute to diminished estrus expression in lame cows. Behavioral scan and focal sampling were used to examine...Full Text Available

2008-12-01

316

Isolation of caprine arthritis encephalitis virus from goats in Mexico.

Laboratory studies were performed to support field-testing of base injection into the F-Area Seepage Basins groundwater. The general purpose of these experiments is to provide information to guide the test of base injection and to identify potential adverse effects.

2001-09-11

317

Isolation and identification of a cobamide coenzyme from the tapeworm Spirometra mansonoides.

A lentivirus was isolated from 2 goats in Mexico that were seropositive to caprine arthritis encephalitis virus (CAEV) by the agar gel immunodiffusion (AGID) test. The lentivirus was identified as CAEV...Full Text Available

1999-07-01

318

In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression

A light-sensitive vitamin B12 derivative has been extracted from the adult cestode, Spirometra mansonoides. This corrinoid was identified as the cobamide coenzyme, adenosylcobalamin, by its chromatographic, chemical, and spectral properties. PMID:1003284

1976-12-01

319

Improving Knowledge and Attitudes towards Depression: a controlled trial among Chinese medical students

Mouse models have dramatically improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic...Full Text Available

2009-10-01

320

Immunoradiometric measurement of the factor VIII procoagulant antigen.

BackgroundEstablishing an evidence-based method of improving knowledge and attitudes concerning depression has been identified as a priority in Chinese medical education. The purpose...Full Text Available

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321

A fluid-phase immunoradiometric assay has been developed which identifies an antigen on the Factor VIII (antihemophilic factor) procoagulant protein. This sensitive and quantitative assay is not influenced...Full Text Available

1978-11-01

322

Identifying barriers to Papanicolaou smear screening in Korean women: Korean National Health and Nutrition Examination Survey 2005

BackgroundA large fraction of the human genome is attributable to L1 retrotransposon sequences. Not only do L1s themselves make up a significant portion of the genome, but L1-encoded...Full Text Available

2003-01-01

323

Identifying and validating biomarkers for Alzheimer's disease

ObjectiveThis study was conducted to provide a nationwide analysis on barriers to cervical cancer screening in Korea.MethodsData used for this study...Full Text Available

2010-06-01

324

Identification of cell cycle-related regulatory motifs using a kernel canonical correlation analysis

The identification and validation of biomarkers for diagnosing Alzheimer's disease (AD) and other forms of dementia are increasingly important. To date, ELISA measurement of β-amyloid(1–42),...Full Text Available

2011-01-01

325

Identification of a stem cell candidate in the normal human prostate gland

BackgroundGene regulation is a key mechanism in higher eukaryotic cellular processes. One of the major challenges in gene regulation studies is to identify regulators affecting the...Full Text Available

326

Identification of a Copper-Responsive Two-Component System on the Chromosome of Escherichia coli K-12

Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+...Full Text Available

2005-03-01

327

Identification of CTX-M-14 Extended-Spectrum ?-Lactamase in Clinical Isolates of Shigella sonnei, Escherichia coli, and Klebsiella pneumoniae in Korea

Using a genetic screen we have identified two chromosomal genes, cusRS (ylcA ybcZ), from Escherichia coli K-12 that encode a two-component, signal...Full Text Available

2000-10-01

328

Identification and mobilization by cointegrate formation of a nodulation plasmid in Rhizobium trifolii.

CTX-M-14 β-lactamase was identified in a stool isolate of Shigella sonnei and in blood isolates of Escherichia coli (one isolate) and Klebsiella pneumoniae...Full Text Available

2001-10-01

329

Identification and Characterization of CPS1 as a Hyaluronic Acid Synthase Contributing to the Pathogenesis of Cryptococcus neoformans Infection?

A nodulation plasmid, pRtr-514a, of molecular size 180 megadaltons (Mdal) was identified in Rhizobium trifolii strain NZP514. This plasmid was absent in both spontaneous and heat-cured Nod- derivatives...Full Text Available

1982-07-01

330

High-Risk Populations Identified in Childhood Cancer Survivor Study Investigations: Implications for Risk-Based Surveillance

Cryptococcus neoformans is a pathogenic yeast that often causes devastating meningoencephalitis in immunocompromised individuals. We have previously identified the C. neoformans...Full Text Available

2007-08-01

331

High affinity of lead for fetal haemoglobin.

Childhood cancer survivors often experience complications related to cancer and its treatment that may adversely affect quality of life and increase the risk of premature death. The purpose of this...Full Text Available

2009-05-10

332

Heterogeneous catalytic alcoholysis of benzonitrile

In-vitro experiments using 203Pb were performed to identify lead-binding components in human haemoglobin. Sephadex A-50 ion-exchange chromatography of haemolysate showed that different types of haemoglobin...Full Text Available

1980-08-01

333

Heritability of Measures of Kidney Disease Among Zuni Indians: The Zuni Kidney Project

The authors investigate the possibility of the direct heterogeneous catalytic synthesis of ethylbenzoate from benzonitrile. The catalysts tested were oxides of aluminium, titanium, and vanadium. The main conversion product detected chromatographically was ethylbenzoate; benzaldehyde, benzamide, and benzanilide were also identified. Aluminium oxide was found to be the most effective catalyst.

1986-04-01

334

Hepatic stellate cells and parasite-induced liver fibrosis

BackgroundThe long-term goal of the GKDZI (Genetics of Kidney Disease in Zuni Indians) Study is to identify genes, environmental factors, and genetic-environmental...Full Text Available

2010-08-01

335

Health professionals rarely record history of complementary and alternative medicines

Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important...Full Text Available

336

Half-trek criterion for generic identifiability of linear structural equation models

AimsTo identify the completeness of documentation of Complementary And Alternative Medicine (CAM) use in hospital medical records of patients before and after an education programme.Full Text Available

2005-02-01

337

HIV prevention for South African youth: which interventions work? A systematic review of current evidence

A linear structural equation model relates random variables of interest and corresponding Gaussian noise terms via a linear equation system. Each such model can be represented by a mixed graph in which directed edges encode the linear equations, and bidirected edges indicate possible correlations among noise terms. We study parameter identifiability in these models, that is, we ask for conditions that ensure that the edge coefficients and correlations appearing in a linear structural equation model can be uniquely recovered from the covariance matrix of the associated normal distribution. We treat the case of generic identifiability, where unique recovery is possible for almost every choice of parameters. We give a new graphical criterion that is sufficient for generic identifiability. It improves criteria from prior work and does not require the directed part of the graph to be acyclic. We also develop a related necessary ...

2011-01-01

338

Granite Countertops and Radiation | Radiation Protection | US EPA

BackgroundIn South Africa, HIV prevalence among youth aged 15-24 is among the world's highest. Given the urgent need to identify effective HIV prevention approaches, this review...Full Text Available

339

Genome-Wide Identification and Evolutionary Analysis of the Animal Specific ETS Transcription Factor Family

... Top of page Testing Radiation coming from granite countertops results from natural radioactive material in the granite. Identifying the presence and concentration of radioactive elements in granite requires expensive and sophisticated portable instruments or laboratory equipment. These instruments and equipment require proper calibration, and interpretation of ...

340

Genetic architecture of voluntary exercise in an advanced intercross line of mice

The ETS proteins are a family of transcription factors (TFs) that regulate a variety of biological processes. We made genome-wide analyses to explore the classification of the ETS gene family. We identified...Full Text Available

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341

Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease

Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations and effects...Full Text Available

2010-07-01

342

Fast, Scalable, Bayesian Spike Identification for Multi-Electrode Arrays

Despite the recent success of genome-wide association studies (GWASs) in identifying loci consistently associated with coronary artery disease (CAD), a large proportion of the genetic components of...Full Text Available

343

Factors governing the periodic activation of supraoptic and paraventricular neurosecretory cells during suckling in the rat.

We present an algorithm to identify individual neural spikes observed on high-density multi-electrode arrays (MEAs). Our method can distinguish large numbers of distinct neural units, even when spikes...Full Text Available

344

Expression and purification of a functional human hepatitis B virus polymerase

1. One hundred and thirty-two antidromically identified paraventricular (PV) and supraoptic (SO) neurones were studied during milk ejection evoked by the suckling of the young, in thirty-four lactating...Full Text Available

1975-09-01

345

Expression and Trans-Specific Polymorphism of Self-Incompatibility RNases in Coffea (Rubiaceae)

AIM: To identify a method for efficient large-scale purification of functional hepatitis B virus polymerase (HBV-Pol) without addition of cellular factors.METHODS: Full-length HBV-Pol (843 amino...Full Text Available

2010-12-07

346

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

Self-incompatibility (SI) is widespread in the angiosperms, but identifying the biochemical components of SI mechanisms has proven to be difficult in most lineages. Coffea (coffee;...Full Text Available

347

Evaluation of the OptiMAL Test for Rapid Diagnosis of Plasmodium vivax and Plasmodium falciparum Malaria

The incidence of melanoma is increasing more than any other cancer, and knowledge of its genetic alterations is limited. To systematically analyze such alterations, we performed whole-exome...Full Text Available

2011-05-01

348

Evaluation of Acyl Coenzyme A Oxidase (Aox) Isozyme Function in the n-Alkane-Assimilating Yeast Yarrowia lipolytica

The development of rapid and specific diagnostic tests to identify individuals infected with malaria is of paramount importance in efforts to control the severe public health impact of this disease....Full Text Available

1998-01-01

349

Evaluating the Involvement of Alternative Sigma Factors SigF and SigG in Clostridium perfringens Sporulation and Enterotoxin Synthesis?

We have identified five acyl coenzyme A (CoA) oxidase isozymes (Aox1 through Aox5) in the n-alkane-assimilating yeast Yarrowia lipolytica, encoded by the POX1...Full Text Available

1999-09-01

350

Establishment of an Immunoglobulin M Antibody-Forming Cell Response Model for Characterizing Immunotoxicity in Primary Human B Cells

Clostridium perfringens type A food poisoning is the second most commonly identified bacterial food-borne illness. Sporulation contributes to this disease in two ways: (i) most food-poisoning...Full Text Available

2010-10-01

351

Energy Performance Contracting for New Buildings

Rodent models have been extensively utilized to identify putative human immunotoxicants; however, even when immunotoxicity is established, uncertainty remains whether the effects are predictive of human...Full Text Available

2009-12-01

352

Employing Kirkpatrick's Evaluation Framework to Determine the Effectiveness of Health Information Management Courses and Programs

situ by isolating portions of the building envelope and performing tests .MAXIMUM ALLOWED LOAD ...and shall identify commissioning team members who will perform testing and prepare documentation.The commissioning agent may be

353

Distribution of lead-203 in human peripheral blood in vitro.

Evaluation of the impact and effectiveness of courses is necessary so that strengths and weaknesses can be identified and improvements made. This article uses Kirkpatrick's evaluation framework to present...Full Text Available

354

Differential neural contributions to native- and foreign-language talker identification

In-vitro experiments using 203Pb were performed to identify the lead binding components in human peripheral blood. The distribution of lead in plasma, in the red cell membrane, and within the red cell...Full Text Available

1980-02-01

355

Developing IT Infrastructure for Rural Hospitals: A Case Study of Benefits and Challenges of Hospital-to-Hospital Partnerships

Humans are remarkably adept at identifying individuals by the sound of their voice, a behavior supported by the nervous system’s ability to integrate information from voice and speech...Full Text Available

2009-12-01

356

Detection and Identification of Ciprofloxacin-Resistant Yersinia pestis by Denaturing High-Performance Liquid Chromatography

This article presents a study identifying benefits and challenges of a novel hospital-to-hospital information technology (IT) outsourcing partnership (HHP). The partnership is an innovative response...Full Text Available

2008-07-01

357

Delineating Bacteriostatic and Bactericidal Targets in Mycobacteria Using IPTG Inducible Antisense Expression

Denaturing high-performance liquid chromatography (DHPLC) has been used extensively to detect genetic variation. We used this method to detect and identify Yersinia pestis KIM5 ciprofloxacin-resistant...Full Text Available

2003-07-01

358

Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence

In order to identify novel high value antibacterial targets it is desirable to delineate whether the inactivation of the target enzyme will lead to bacterial death or stasis. This knowledge is particularly...Full Text Available

359

Deep Desulfurization of Diesel Oil and Crude Oils by a Newly Isolated Rhodococcus erythropolis Strain

The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia. Interest in this zoonotic pathogen has increased due to its classification as a category A agent...Full Text Available

2006-08-22

360

DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase

The soil-isolated strain XP was identified as Rhodococcus erythropolis. R. erythropolis XP could efficiently desulfurize benzonaphthothiophene, a complicated model sulfur compound that...Full Text Available

2006-01-01

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361

DECOMP: A PDB decomposition tool on the web

CDC7 is an essential gene required for DNA replication in Saccharomyces cerevisiae. Cdc7p homologs have recently been identified in vertebrates, but their role in DNA...Full Text Available

1999-03-16

362

Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies.

The protein databank (PDB) contains high quality structural data for computational structural biology investigations. We have earlier described a fast tool (the decomp_pdb tool) for identifying and...Full Text Available

363

Coryneform bacteria in infectious diseases: clinical and laboratory aspects.

The authors have recently identified a new cytokeratin (CK) polypeptide, CK 20, whose expression is almost entirely confined to the gastric and intestinal epithelium, urothelium, and Merkel cells. Seven...Full Text Available

1992-02-01

364

Confirmation of human Campylobacter concisus isolates misidentified as Campylobacter mucosalis and suggestions for improved differentiation between the two species.

Coryneform isolates from clinical specimens frequently cannot be identified by either reference laboratories or research laboratories. Many of these organisms are skin flora that belong to a large number...Full Text Available

1990-07-01

365

Comparison of Different Measures of Urinary Protein Excretion for Prediction of Renal Events

A strain from human diarrhea originally identified as Campylobacter mucosalis (NCTC 12408) was examined by using 64 phenotypic characters. The similarity of this strain to 297 isolates of Campylobacter,...Full Text Available

1994-09-01

366

Comparative analysis of cis-regulation following stroke and seizures in subspaces of conserved eigensystems

There are many methods to screen for abnormal amounts of proteinuria to identify patients at risk for progression of renal disease, but which method best predicts renal risk is unknown. Here, we analyzed...Full Text Available

2010-08-01

367

Coal to liquids technology (Overview - Research)

BackgroundIt is often desirable to separate effects of different regulators on gene expression, or to identify effects of the same regulator across several systems. Here, we focus...Full Text Available

368

Clinical Correlates to Laboratory Measures for use in Non-Contact Anterior Cruciate Ligament Injury Risk Prediction Algorithm

... After completing a review into direct coal liquefaction research carried out in Australia and internationally, CSIRO has identified potential new science and technology developments that may improve the cost and viability of CTL in a greenhouse gas-constrained environment. We are conducting research to: determine the optimum ...

369

Climate Change, Genetics or Human Choice: Why Were the Shells of Mankind's Earliest Ornament Larger in the Pleistocene Than in the Holocene?

BackgroundProspective measures of high knee abduction moment during landing identify female athletes at high risk for non-contact anterior cruciate ligament injury....Full Text Available

2010-08-01

370

Characterization of Two Unique Cholesterol-Rich Lipid Particles Isolated from Human Atherosclerotic Lesions

BackgroundThe southern African tick shell, Nassarius kraussianus (Dunker, 1846), has been identified as being the earliest known ornamental object used by human...Full Text Available

371

Chaotic system of two-phase flow in a small, horizontal, rectangular channel.

The authors' laboratory, using histochemicalmethods, previously identified two types of cholesterol-containing lipid particles in the extracellular spaces of human atherosclerotic lesions, one particle...Full Text Available

1990-01-01

372

Central gating of fly optomotor response

Various measurement tools that are used in chaos theory were applied to analyze two-phase pressure signals with the objective of identifying and interpreting flow pattern transitions for two-phase flows in a small, horizontal rectangular channel. These me...

1995-01-01

373

Carpal Tunnel Syndrome and Peripheral Polyneuropathy in Patients with End Stage Kidney Disease

We study the integration of multisensory and central input at the level of an identified fly motoneuron, the ventral cervical nerve motoneuron (VCNM) cell, which controls head movements of the animal....Full Text Available

2010-11-16

374

Cancer in young people in the north of England, 1968-85: analysis by census wards.

This study was designed to identify the causes of the development of carpal tunnel syndrome (CTS) associated with end stage kidney disease (ESKD). A total of 112 patients with ESKD, 64 on hemodialysis...Full Text Available

2011-09-01

375

CD133 Positive Embryonal Rhabdomyosarcoma Stem-Like Cell Population Is Enriched in Rhabdospheres

OBJECTIVE--To determine whether the seeming excess of childhood leukaemia and lymphoma identified in Seascale, Cumbria, UK, remains unusual when put into a wider context. DESIGN--Analysis of cancer...Full Text Available

1993-04-01

376

Burnout sensitivity of power MOSFETs operating in a switching converter

Cancer stem cells (CSCs) have been identified in a number of solid tumors, but not yet in rhabdomyosarcoma (RMS), the most frequently occurring soft tissue tumor in childhood. Hence, the aim of this...Full Text Available

377

Brain transcriptomic analysis in paper wasps identifies genes associated with behaviour across social insect lineages

Heavy ion tests of a switching converter using power MOSFETs have allowed us to identify the main parameters which affect the burnout sensitivity of these components. The differences between static and dynamic conditions are clarified in this paper. (author). 7 refs., 16 figs., 3 tabs.

378

Boron Tolerance in Barley Is Mediated by Efflux of Boron from the Roots1

Comparative sociogenomics has the potential to provide important insights into how social behaviour evolved. We examined brain gene expression profiles of the primitively eusocial wasp Polistes...Full Text Available

2010-07-22

379

Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound

Many plants are known to reduce the toxic effects of high soil boron (B) by reducing uptake of B, but no mechanism for limiting uptake has previously been identified. The B-tolerant cultivar of barley...Full Text Available

2004-10-01

380

Biochemical analysis of PIFTC3, the Trypanosoma brucei ortholog of nematode DYF-13, reveals interactions with established and putative intraflagellar transport components

Fish living in contaminated environments accumulate toxic chemicals in their tissues. Biomarkers are needed to identify the resulting health effects, particularly focusing on early changes at a subcellular...Full Text Available

2006-06-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

Biobank resources for future patient care: developments, principles and concepts

DYF-13, originally identified in C. elegans within a collection of dye-filling chemosensory mutants, is one of several proteins that have been classified as putatively involved...Full Text Available

2010-10-01

382

Bacterial response to siderophore and quorum-sensing chemical signals in the seawater microbial community

The aim of the overview is to give a perspective of global biobank development is given in a view of positioning biobanking as a key resource for healthcare to identify new potential markers that can...Full Text Available

383

Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells

BackgroundOceans are iron-deficient and nutrient-poor environments. These conditions impart limitations on our understanding of and our ability to identify microorganisms from the...Full Text Available

384

Bacterial Competition for Human Nasal Cavity Colonization: Role of Staphylococcal agr Alleles

The CD1 family of proteins binds self and foreign glycolipids for presentation to CD1-restricted T cells. To identify previously uncharacterized active CD1 ligands, especially those of microbial origin,...Full Text Available

2005-02-01

385

Autophosphorylation Within the Atg1 Activation Loop Is Required for Both Kinase Activity and the Induction of Autophagy in Saccharomyces cerevisiae

We examined the bacterial aerobic nasal flora of 216 healthy volunteers to identify potential competitive interactions among different species, with special emphasis on the influence of staphylococcal...Full Text Available

2003-01-01

386

Associations between dairy production indices and lipoarabinomannan enzyme-immunoassay results for paratuberculosis.

Autophagy is an evolutionarily conserved degradative pathway that has been implicated in a number of physiological events important for human health. This process was originally identified as a response...Full Text Available

2010-07-01

387

Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study

Data from an epidemiological study in Ontario, involving 304 dairy herds, were used to identify associations between selected production indices and lipoarabinomannan antigen serological test results...Full Text Available

1991-10-01

388

Army energy plan. Technical report

IntroductionThe goal of this study was to identify serum markers that are modulated by treatment with golimumab with or without methotrexate (MTX) and are associated with clinical...Full Text Available

2010-01-01

389

Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-?B-dependent iNOS and proinflammatory cytokines production

The Plan identifies the Army's organization, goals, objectives, and policies with respect to energy. It projects energy consumption and costs to the year 2000 and summarizes the programs required to support the long range goals. A summary of current and needed energy related legislation is included. (Author)

1978-02-24

390

Anti-beta-endorphin immunoglobulin G in humans.

Background and purpose:Glycyrrhizae radix has been widely used as a cytoprotective, plant-derived medicine. We have identified a flavanoid, liquiritigenin, as an...Full Text Available

2008-05-01

391

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast

Human IgG specific for beta-endorphin was identified by enzyme-linked immunoabsorbent assay and isolated by affinity chromatography. From a sample of 27 subjects, three individuals with major depression...Full Text Available

1986-11-01

392

Analysis of target cell susceptibility as a basis for the development of a chemoprotective strategy against benzene-induced hematotoxicities.

BackgroundHistone post-translational modifications are critical for gene expression and cell viability. A broad spectrum of histone lysine residues have been identified in yeast...Full Text Available

393

Analysis of Failed Spinal Cord Stimulation Trials in the Treatment of Intractable Chronic Pain

A goal of our research is to identify biochemical factors that underlie the susceptibility of bone marrow cell populations to benzene metabolites so as to develop a mechanistically based chemoprotective...Full Text Available

1996-12-01

394

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer

ObjectiveThe purpose of this study is to identify the factors affecting the failure of trials (<50% pain reduction in pain for trial period) to improve success rate of spinal...Full Text Available

2008-02-01

395

An Intrinsic Neuronal Oscillator Underlies Dopaminergic Neuron Bursting

BackgroundGenomics has substantially changed our approach to cancer research. Gene expression profiling, for example, has been utilized to delineate subtypes of cancer, and facilitated...Full Text Available

396

Amazon.com: Customer Reviews: Womenomics: Write Your Own Rules for Success

Dopaminergic neurons of the ventral midbrain fire high frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can...Full Text Available

2009-12-16

397

Alcohol and the fetus in the west of Scotland.

...Own Rules for Success (Hardcover) The authors have rightly identified that there is a growing demand for, trend towards, and interest in guidance for creating flexible working arrangements. However, for $27.99, you can secure more concrete advice on reaching your \\

398

Accuracy of Contacts Calculated from 3D Images of Occlusal Surfaces

Forty children with the fetal alcohol syndrome were identified in the west of Scotland. All were growth retarded and had abnormal facial features, and all those who were tested were found to have neurological...Full Text Available

1983-07-02

399

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

ObjectiveCompare occlusal contacts calculated from 3D virtual models created from clinical records to contacts identified clinically using shimstock and transillumination.Full Text Available

2007-06-01

400

A polyacetylene compound from herbal medicine regulates genes associated with thrombosis in endothelial cells

SUMMARYATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as...Full Text Available

2010-08-20

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

A new VCAN/versican splice acceptor site mutation in a French Wagner family associated with vascular and inflammatory ocular features

From Toki-shakuyaku-san, an herbal formulation for “cleansing stagnated blood,” a key gene regulatory compound was purified and identified through a screening based on DNA microarray...Full Text Available

2007-12-15

402

A Web-based Interface for Communication of Data between the Clinical and Research Environments without Revealing Identifying Information

PurposeTo detail the highly variable ocular phenotypes of a French family affected with an autosomal dominantly inherited vitreoretinopathy and to identify the disease gene.MethodsSixteen...Full Text Available

403

A Novel Mouse Model of Red Blood Cell Storage and Post-Transfusion in Vivo Survival

Recent health care policies and regulations have impacted the manner in which patient data – especially protected health information (PHI) – are handled in both the clinical...Full Text Available

2007-06-01

404

A NEW APPROACH TO UNDERSTANDING THE MOLECULAR MECHANISMS THROUGH WHICH ESTROGENS AFFECT COGNITION

BackgroundStorage of RBCs is necessary for an adequate blood supply. However, reports have identified potential negative sequelae of transfusing stored RBCs. An animal...Full Text Available

2009-08-01

405

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice

Traditional approaches to the study of hormones and cognition have been primarily observational or correlational in nature. Because this work does not permit causal relationships to be identified,...Full Text Available

2010-10-01

406

A Hemorrhagic Factor (Apicidin) Produced by Toxic Fusarium Isolates from Soybean Seeds

Humanin (HN), a 24-residue peptide, was identified as a novel neuroprotective factor and shows anti-cell death activity against a wide spectrum of Alzheimer's disease (AD)-related cytotoxicities, including...Full Text Available

407

A Disordered Eating Response Team's Effect on Nutrition Practices in College Athletes

Fifty-two isolates of Fusarium species were obtained from soybean seeds from various parts of Korea and identified as Fusarium oxysporum, F. moniliforme,...Full Text Available

1999-01-01

408

A Cytogenetic Abnormality and Rare Coding Variants Identify ABCA13 as a Candidate Gene in Schizophrenia, Bipolar Disorder, and Depression

The disordered eating response team developed a protocol for assessment and intervention for athletes who are identified as at risk for disordered eating. Team members included the team physician,...Full Text Available

1995-10-01

409

A Computer Vision System for Automated Grading of Rough Hardwood Lumber Using a Knowledge-Based Approach

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of ∼80% indicating a substantial genetic component. Population genetics...Full Text Available

2009-12-11

410

A Comparison of intra-oral digital imaging modalities: Charged Couple Device versus Storage Phosphor Plate

... in this paper is aimed at developing a computer vision system that will be used to automatically grade rough hardwood lumber. The purpose of the computer vision system is to locate and identify grading def...

411

45 CFR 1175.110 - Self-evaluation.

BackgroundThis in vitro study was conducted to compare the accuracy of two digital image receptors in identifying the location of tip of a fine endodontic file and radiographic apex...Full Text Available

2010-11-01

412

¹H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis

...shall, until three years following the completion of the self-evaluation, maintain on file and make available for public inspections: (1) A description of areas examined and any problems identified, and (2) A description of any...

2010-10-01

413

Waste Sampling and Characterization Facility (WSCF). Maintenance Implementation Plan

BackgroundPathophysiological mechanisms involved in amyotrophic lateral sclerosis (ALS) are complex and none has identified reliable markers useful in routine patient evaluation....Full Text Available

414

Theory and method for selection of power system stabilizer location

This Maintenance Implementation Plan has been developed for maintenance functions associated with the Waste Sampling and Characterization Facility (WSCF). This plan is developed from the guidelines presented by Department of Energy (DOE) Order 4330.4A, Maintenance Management Program (DOE 1990), Chapter II. The objective of this plan is to provide baseline information for establishing and identifying WHC conformance programs and policies applicable to implementation of DOE order 4330.4A guidelines. In addition, this maintenance plan identifies the actions necessary to develop a cost-effective and efficient maintenance program at WSCF.

1993-07-01

415

RAPID DAMAGE ASSESSMENT FROM HIGH RESOLUTION IMAGERY

A new approach for the selection of best PSS locations in multimachine power systems is proposed in this paper. Study shows that the right-eigenvector measures the activity of state variables and the left-eigenvector measures the control effect of control signals. Based on the right and left eigenvector the concept of sensitivity of PSS effect (SPE) is presented and used to identify the best PSS locations. The proposed method is used to identify the best PSS location in a 13-machine system to increase the damping of an interarea mode. The time-domain simulation results confirm that the prediction of best PSS location by SPE method is correct and accurate.

1991-03-01

416

Patient isolation in chronic benign pain.

Disaster impact modeling and analysis uses huge volumes of image data that are produced immediately following a natural or an anthropogenic disaster event. Rapid damage assessment is the key to time critical decision support in disaster management to better utilize available response resources and accelerate recovery and relief efforts. But exploiting huge volumes of high resolution image data for identifying damaged areas with robust consistency in near real time is a challenging task. In this paper, we present an automated image analysis technique to identify areas of structural damage from high resolution optical satellite data using features based on image content.

2008-07-01

417

Opportunities for coal liquefaction research in British Columbia

Over the years, nurses, doctors and scientists have sought ways of assessing the impact of pain on patients. While many of the instruments devised have been extremely useful in identifying the nature and intensity of pain, defining the effect it has on people's lives and perceptions has proved much more problematic. Based on the work she carried out with patients suffering from chronic benign pain, Karen Rose explores one aspect of these effects--the feeling of isolation. By using a four-step anthropological approach to identify the impact of pain, she argues, nurses can arrive at a realistic and accurate assessment of how patients are coping. PMID:7947167

418

Lack of awareness of symptoms in people with dementia: the structural and functional basis

This paper presents the results of a study commissioned by the British Columbia Science Council to identify opportunities for liquefaction of B.C. coals and to recommend effective approaches to the development of a research program on coal conversion. Contains reviews of British Columbia coal resources to identify prospective candidates for conversion to liquid fuels; of the state of the art in the various processes for the conversion of coal to liquid fuels with particular emphasis on those processes most relevant to British Columbia applications; and of research opportunities in British Columbia for the development of coal liquefaction technology. (16 refs.)

1980-05-01

419

British Library Electronic Table of Contents (United Kingdom)

AbstractObjective To review studies investigating the brain correlates of unawareness of cognitive and behavioural symptoms in people with dementia. Design A detailed search of the literature was conducted to include all the peer-reviewed studies published in English aimed at identifying the structural or functional brain correspondents of unawareness in dementia patients. Their results were interpreted in relation to the methodological differences in terms of type of dementia studied, the protocol adopted to measure lack of awareness, the imaging techniques employed, the experimental designs and statistical analyses performed. Results Eighteen studies undertaken to explore the functional and structural correlates of unawareness of cognitive symptoms in dementia were identified. Although t...

2011-01-01

420

How the Energy and Water Development Appropriations Act of 1993 has impacted the constitutional dynamics of federal wetlands delineation and regulation

Hazard Evaluation for the Saltwell Chempump and a Saltwell Centrifugal Pump Design using Service Water for Lubrication and Cooling

A reliable source of specific criteria for recognizing a wetland, as defined for regulatory purposes would be valuable. In 1987 the Army Corps of Engineers developed a technical manual for identifying wetlands (1987 Wetlands Manual). An interagency manual (1989 Wetlands Manual) was later developed. This manual has been used to identify wetlands according to three evidentiary factors: vegetation, hydrology, and soil. This paper addresses the development of criteria to delineate wetlands, and describes some of the logic used by federal courts to uphold the limited constitutional use of the 1989 Wetlands Manual.

1995-12-31

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

Effect of the size of an artificial neural network used as pattern identifier

This report documents results of a preliminary hazard analysis (PHA) covering the existing Crane Chempump and the new salt well pumping design. Three hazardous conditions were identified for the Chempump and ten hazardous conditions were identified for the new salt well pump design. This report also presents the results of the control decision/allocation process. A backflow preventer and associated limiting condition for operation were assigned to one hazardous condition with the new design.

2000-11-16

422

Cost-time management: A powerful tool in a new application - cleaning up the weapons complex

A novel way to extract relevant parameters associated with the outgoing ions from nuclear reactions, obtained by digitizing the signals provided by a Bragg curve spectrometer (BCS) is presented. This allowed the implementation of a more thorough pulse-shape analysis. Due to the complexity of this task, it was required to take advantage of new and more powerful computational paradigms. This was fulfilled using a back-propagation artificial neural network (ANN) as a pattern identifier. Over training of ANNs is a common problem during the training stage. In the performance of the ANN there is a compromise between its size and the size of the training set. Here, this effect will be illustrated in relation to the problem of Bragg Curve (BC) identification. (Author)

2003-07-01

423

Competencies of Employment Specialists for Effective Job Development

Westinghouse Electric Corporation is aggressively applying cost-time management to bolster timely, cost-effective cleanup and waste management activities at sites it manages for the U.S. Department of Energy (DOE). Cost-time management is a diagnostic technique which is applicable to virtually any process. It identifies opportunities to reduce cycle-times and costs. When applied to cleanup and waste management at DOE facilities, cost-time profile analysis helps identify actions to improve productivity and quality. Moreover, by reducing cycle-times and costs, it achieves significant savings to taxpayers. (author)

1992-03-01

424

British Library Electronic Table of Contents (United Kingdom)

A scant body of literature addresses competencies needed for successful job development. This study aimed to identify competencies needed for this role. In this analysis, we observed employment specialists identified as successful in helping consumers obtain employment perform job development duties. We supplemented observations with interviews. Employment specialists possessed competencies in six domains: time management, advocacy, building partnerships with consumers, working as part of a team, face-to-face communication, and networking. The conceptual framework derived from this study can inform supported employment supervisors and researchers about the competencies that can strengthen supported employment teams.

2011-01-01

425

biotechnological studies on the effect of gamma rays on peanut

Transient enhanced diffusion from decaborane molecular ion implantation

local peanut cultivars Giza 4 and Giza 5 were exposed to different doses ( 50,100,150,200,250 and 300 Gy)to Co "6"0 gamma ray source . all irradiated materials were cultivated to give the M_1 and M_2 generation , then high yielding mutants were selected from the M_2 generation and cultivated separately to give the M_3 generation. some yield component traits were measured for the three generations (M_1,M_2 and M_3) and M_3 families.variations observed in these traits were attributed to genetic factors. the M_3 selected mutants were artificially infected by aspergillus flavus L spores (aflatoxins-B1 and B2 groups-producer strain). aflatoxin concentrations were estimated and the analysis showed that aflatoxin concentrations in seeds of the M_3 selected mutants from cultivar Giza 4 were higher than those in seeds of the M3 mutants selected from cultivar Giza 5. however, the concentration of aflatoxin increased when the yield ( weight of seeds per ...

2007-01-01

426

The effect of ethanol on "3"5-S-TBPS binding to mouse brain membranes in the presence of chloride

Transient enhanced diffusion (TED) from implantation of 5keVB_1_0H_1_4 and 0.5 keV B ions has been quantified and compared for nominal boron doses of 10"1"4 and 10"1"5cm"-"2. Boron diffusivity during annealing was extracted from secondary ion mass spectroscopy depth profiles of diffused marker layers in boron doping-superlattices and the actual implanted B dose was independently measured by nuclear reaction analysis. Comparable enhancements were observed from both ions. Transmission electron microscopy analysis revealed that both boron- and decaborane-implanted samples were amorphized at a nominal 10"1"5cm"-"2B dose. A comparison with data from low energy Si implants revealed a similar dependence of diffusivity enhancement on implant dose. These findings are consistent with the understanding that TED is caused by the interstitial supersaturation resulting from a number of excess interstitials approximately equal to the number of implanted atoms which can become substitutional in the ...

1998-10-01

427

Proteomic Profiling of Mesenchymal Stem Cell Responses to Mechanical Strain and TGF-B1

The effect of in vitro and in vivo administration of ethanol on the binding of "3"5S-t-butyl-bicyclophosphorothionate ("3"5S-TBPS) to cortical brain membranes of C57B1 mice was investigated using KCl (100 mM) containing assay media. The in vitro addition of ethanol produced a dose-dependent inhibition of basal "3"5S-TBPS binding. In the presence of chloride ions, GABA and pentobarbital had a biphasic action (stimulation followed by inhibition) on "3"5S-TBPS binding, whereas diazepam only stimulated the binding. Ethanol reduced the stimulatory effects of GABA and pentobarbital in a dose-dependent manner, but had no effect on the enhancement of "3"5S-TBPS binding produced by diazepam. "3"5S-TBPS binding to cortical brain membranes was inhibited by the putative Cl"- channel blocking agent DIDS. This inhibitory action of DIDS was significantly, and dose-dependently reduced by ethanol (#<=# 100 mM ethanol). Chronic ethanol ingestion in vivo, ...

428

Prospects and future of conservative management of beta thalassemia major in a developing country

Mesenchymal stem cells (MSCs) are a potential source of smooth muscle cells (SMCs) for constructing tissue-engineered vascular grafts. However, the details of how specific combinations of vascular microenvironmental factors regulate MSCs are not well understood. Previous studies have suggested that both mechanical stimulation with uniaxial cyclic strain and chemical stimulation with transforming growth factor {beta}1 (TGF-{beta}1) can induce smooth muscle markers in MSCs. In this study, we investigated the combined effects of uniaxial cyclic strain and TGF-{beta}1 stimulation on MSCs. By using a proteomic analysis, we found differential regulation of several proteins and genes, such as the up-regulation of TGF-{beta}1-induced protein ig-h3 (BGH3) protein levels by TGF-{beta}1 and up-regulation of calponin 3 protein level by cyclic strain. At the gene expression level, BGH3 was induced by TGF-{beta}1, but calponin 3 was not significantly regulated by mechanical strain or TGF-{beta}1, ...

2009-10-12

429

Projected change in climate thresholds in the Northeastern U.S.: implications for crops, pests, livestock, and farmers

Objective: To assess the efficacy, prospects and future of conservative management of beta thalassemia major patients in a developing country. Design: Patients registered at IHBTS were studied over a period of three years. They consented to being managed on moderate transfusion regimen, aiming to maintain a pre-transfusion haemoglobin(Hgb) level of 9.0 plus minus 1.0 g per dL. We studied their transfusion requirements, status for transfusion transmitted infections (TTls), serum ferritin levels and complications developing as a result of iron overload. Subjects: Initially all registered patients were included in this study. Sporadic patients as well as dropouts occurring due to any reason, (patients concurrently seeking treatment at other centres as well, or complying poorly to advised chelation therapy) were excluded from the study. The data presented here conforms to a cohort of 60 regular patients who adhered best to our selection criteria. Main Outcome Measures: 1) The study ...

2004-01-01

430

Photodissociation dynamics of doubly excited Rydberg states of molecular hydrogen

Most prior climate change assessments for U.S. agriculture have focused on major world food crops such as wheat and maize. While useful from a national and global perspective, these results are not particularly relevant to the Northeastern U.S. agriculture economy, which is dominated by dairy milk production, and high-value horticultural crops such as apples (Malus domestica), grapes (vitis vinifera), sweet corn (Zea mays var. rugosa), cabbage (Brassica oleracea var. capitata), and maple syrup (sugar maple, Acer saccharum). We used statistically downscaled climate projections generated by the HadCM3 atmosphere-ocean general circulation model, run with Intergovernmental Panel on Climate Change future emissions scenarios Alfi (higher) and B1 (lower), to evaluate several climate thresholds of direct relevance to agriculture in the region. A longer (frostfree) growing season could create new opportunities for farmers with enough capital to take ...

2008-07-01

431

Internalized insulin-receptor complexes are unidirectionally translocated to chloroquine-sensitive degradative sites. Dependence on metabolic energy

We have applied photofragment ion imaging to investigate the dissociation dynamics of low-lying, doubly excited states of molecular hydrogen. A doubly excited electronic state is one in which both of the hydrogen electrons reside in excited molecular orbitals. Two-step, two-color multiphoton excitation of H_2, first via 201.8 nm, two-photon excitation into the E, F "1#SIGMA#"+_g(v_E=0, J=1) state, followed by #approx#563 nm, 1+m (m=1, 2) excitation through the B double-prime "1#SIGMA#"+_u(v=0, J=0, 2), D "1#PI#_u(v=2, J=1, 2), and B' "1#SIGMA#"+_u(v=4, J=0, 2) states provides a ready means of populating several low-lying doubly excited states of H_2 at increasing internuclear separations. From these doubly excited repulsive states, both dissociation and autoionization processes are possible. Because the excitation energy remains relatively constant as each intermediate state is accessed, differences in the photodissociation dynamics via each ...

432

Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity

Insulin receptors on the surface of isolated rat adipocytes were photoaffinity labeled at 12 degrees C with the iodinated photoreactive insulin analogue, 125I-B2 (2-nitro-4-azidophenylacetyl)-des-PheB1-insulin, and the pathways in the intracellular processing of the labeled receptors were studied at 37 degrees C. During 37 degrees C incubations, the labeled 440-kDa insulin receptors were continuously internalized (as assessed by trypsin inaccessibility) and degraded such that up to 50% of the initially labeled receptors were lost by 120 min. Metabolic poisons (0.125-0.75 mM 2,4-dinitrophenol (DNP) and 1-10 mM NaF), which led to dose-dependent depletion of adipocyte ATP pools, inhibited receptor loss, and caused up to 3-fold increase in intracellular receptor accumulation. This effect was due to inhibition of intracellular receptor degradation, and there was no apparent effect of the metabolic poisons on initial internalization of the receptors. ...

1988-04-25

433

Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.

1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) is an anti-inflammatory agent with a propenone moiety and chemically synthesized recently. In this study, we examined the chemopreventive effect of FPP-3 on 7,12-dimethylbenz[a]anthracene (DMBA)-induced genotoxicity in MCF-7 cells. FPP-3 reduced the formation of the DMBA-DNA adduct. DMBA-induced CYP1A1 and CYP1B1 gene expression and enzyme activity were inhibited by FPP-3. It inhibited DMBA-induced aryl hydrocarbon receptor (AhR) transactivation and DMBA-inducible nuclear localization of the AhR. Induction of detoxifying phase II genes by chemopreventive agents represents a coordinated protective response against oxidative stress and neoplastic effects of carcinogens. Transcription factor NF-E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase II detoxifying and antioxidant enzymes, such as glutathione S-transferase (GST) and NAD(P)H:quinone oxidoreductase (QR). FPP-3 ...

2008-05-01

434

Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution

African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more productive Bos indicus zebu breeds are much more susceptible. Zebu cattle are well adapted for plowing and haulage, and increasing their tolerance of trypanosomiasis could have a major impact on crop cultivation as well as dairy and beef production. We used three strategies to obtain short lists of candidate genes within QTL that were previously shown to regulate response to infection. We analyzed the transcriptomes of trypanotolerant N'Dama and susceptible Boran cattle after infection with Trypanosoma congolense. We sequenced EST libraries from these two breeds to identify polymorphisms that might underlie previously identified quantitative trait loci (QTL), and we assessed QTL regions and candidate loci for evidence of selective ...

2011-05-18

435

Virtual colonoscopy (CT colonography) in the identification of colorectal cancer. A prospective study in symptomatic patients

The DNA sequence motif ATTTGCAT (octamer) or its inverse complement has been identified as an evolutionarily conserved element in the promoter region of immunoglobulin genes. Two major DNA-binding proteins that bind in a sequence-specific manner to the octamer DNA sequence have been identified in mammalian species--a ubiquitously expressed protein (Oct-1) and a lymphoid-specific protein (Oct-2). During characterization of the promoter region of the chicken immunoglobulin light chain gene, the authors identified two homologous octamer-binding proteins in chicken B cells. when the cloning of the human gene for Oct-2 revealed it to be a member of a distinct family of homeobox genes, they sought to determine if the human Oct-2 cDNA could be used to identify homologous chicken homeobox genes. Using a human Oct-2 homeobox-specific DNA probe, they were able to identify 6-10 ...

1990-02-01

436

Transient performance of FFTF [Fast Flux Test Facility] reference fuel

Aim of this study was to evaluate the sensitivity of virtual colonoscopy (CT colonography) in the identification of colorectal cancer and to define the limitations and the advantages of this imaging modality, as well as indications to the examination. It was examined prospectively 62 symptomatic patients aged 36 to 82 years (28 women and 34 men). All patients underwent both conventional and virtual colonoscopy on the same day; the conventional examination allowed exploration of the entire colon. Conventional colonoscopy identified 89 lesions 3-50 mm in diameter, namely 84 benign and 5 malignant lesions. No lesions were identified in 12 patients. CT colonography identified 52 of the 89 lesions, with 57.1% diagnostic accuracy. They were 11 false positives (82.5% positive predictive value and 52.2% specificity) and 37 false negatives (24.5% negative predictive value and 58.4% sensitivity). Sensitivity was significantly higher ...

2000-06-01

437

Reflexibility in Problem Solving: The Social Context of Expertise. Report No. 13.

Fourteen irradiated Fast Flux Test Facility (FFTF) fuel pins were subjected to representative overpower transients in six flowing sodium loop experiments conducted in the TREAT reactor. The transient tests were extended to substantial overpower levels well beyond protected levels, with some tests intentionally run to failure to identify failure thresholds and characteristics. Test variables included transient ramp rate (5, 50, and 100 cents/s) and burnup (2 to 58 MWd/kg). Performance limits and failure characteristics were identified, and cladding strain and fuel melting data were obtained for development and verification of transient analysis codes. The test results demonstrated that FFTF Reference fuel pins are capable of surviving overpower levels well beyond the FFTF secondary Plant Protection System (PPS) trip limit of 1.25 times normal rated power. Based on analytical evaluations to interpolate and extrapolate test results to the full ...

1986-09-07

438

Overview of the environmental concerns of coal transportation

A series of studies conducted to identify the factors that block and unblock problem solving is described. Through the construction of an isomorph of the classic "water jar" problems developed by A. S. Luchins (1942) as a dynamic graphic micro-world, several factors involved in producing blocked states were identified. Subjects included 10 individuals and 10 pairs of subjects. By comparing the behavior of individuals tackling the "missionaries and cannibals" problem to that of pairs of subjects solving this problem, a study identified means by which problem solvers operating in a social context are able to overcome blocks that discourage individuals. These studies point to the importance of "reflection" (evaluation of problem-solving results) for flexible problem solving. This research suggests that teaching students to analyze what they have done will help them develop flexibility in using a new approach when blocked. The ...

1986-08-01

439

Obsidians and tektites: Natural analogues for water diffusion in nuclear waste glasses

More than 30 environmental concerns were analyzed for the transportation of coal by rail, roads (trucks), high voltage transmission lines (that is, from mine-mouth generating plants to distribution networks), coal slurry pipelines, and barges. The following criteria were used to identify these problems: (1) real physical environmetal impacts for which control technologies must be developed, or regulation made effective where control technologies presently exist; (2) the level of impact is uncertain, although the potential impact may be moderate to high; (3) the concerns identified by the first two criteria are specific to or exacerbated by coal transportation. Generic transportation problems are not included. The significant environmental problems identified as a result of this study are: (1) rail transport - community traffic disruption and human health, safety, and habitat destruction; (2) coal haul roads - road ...

1980-02-01

440

Multidimensional two-phase flow regime distribution in a PWR downcomer during an LBLOCA refill phase

Projected scenarios for the proposed Yucca Mountain repository include significant periods of time when high relative humidity atmospheres will be present, thus the reaction processes of interest will include those known to occur under these conditions. The ideal natural analog for the proposed Yucca Mountain repository would consist of natural borosilicate glasses exposed to expected repository conditions for thousands of years; however, the prospects for identifying such an analog are remote, but an important caveat for using natural analog studies is to relate the reaction processes in the analog to those in the system of interest, rather than a strict comparison of the glass compositions. In lieu of this, identifying natural glasses that have reacted via reaction processes expected in the repository is the most attractive option. The goal of this study is to quantify molecular water diffusion in the natural analogs obsidian and tektites. ...

1991-11-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Multidimensional two-phase flow regime distribution in a PWR downcomer during an LBLOCA refill phase

The multidimensional countercurrent two-phase flow regimes that occur in a pressurized-water reactor (PWR) vessel downcomer during the refill phase of a large-break loss-of-coolant accident are studied using a transparent 1/10 scale model of a PWR vessel. The various flow regimes and their distribution in the downcomer have been identified and mapped for a range of air-water flooding experiments. The two-phase flow patterns that are identified in the downcomer included various types of film flows, droplet flows, countercurrent churn flows and cocurrent flows depending on the flooding condition. Through observation of the two-phase flow dynamics it was deduced that the physical mechanisms associated with the flooding processes could be separated into a liquid entrainment process and a film flow reversal process. In addition to the above exercise, the effect of non-uniform injection of water into the downcomer via different combinations of cold ...

1994-09-01

442

Gear crack level identification based on weighted K nearest neighbor classification algorithm

The multidimensional countercurrent two-phase flow regimes that occur in a pressurized-water reactor (PWR) vessel downcomer during the refill phase of a large-break loss-of-coolant accident are studied using a transparent 1/10 scale model of a PWR vessel. The various flow regimes and their distribution in the downcomer have been identified and mapped for a range of air-water flooding experiments. The two-phase flow patterns that are identified in the downcomer included various types of film flows, droplet flows, countercurrent churn flows and cocurrent flows depending on the flooding condition. Through observation of the two-phase flow dynamics it was deduced that the physical mechanisms associated with the flooding processes could be separated into a liquid entrainment process and a film flow reversal process. In addition to the above exercise, the effect of non-uniform injection of water into the downcomer via different combinations of cold ...

1993-10-01

443

Damping inter-area modes of oscillation using an adaptive fuzzy power system stabilizer

A crack fault is one of the damage modes most frequently occurring in gears. Identifying different crack levels, especially for early cracks is a challenge in gear fault diagnosis. This paper aims to propose a method to classify the different levels of gear cracks automatically and reliably. In this method, feature parameters in time domain, specially designed for gear damage detection and in frequency domain are extracted to characterize the gear conditions. A two-stage feature selection and weighting technique (TFSWT) via Euclidean distance evaluation technique (EDET) is presented and adopted to select sensitive features and remove fault-unrelated features. A weighted K nearest neighbor (WKNN) classification algorithm is utilized to identify the gear crack levels. The gear crack experiments were conducted and the vibration signals were captured from the gears under different loads and motor speeds. The proposed method is applied to ...

2009-07-01

444

Can We Use Common Clinical Parameters to Identify Patients Who Will Need Insulin Treatment in Gestational Diabetes?

This paper introduces an indirect adaptive fuzzy controller as a power system stabilizer used to damp inter-area modes of oscillation following disturbances in power systems. Compared to the IEEE standard multi-band power system stabilizer (MB-PSS), indirect adaptive fuzzy-based stabilizers are more efficient because they can cope with oscillations at different operating points. A nominal model of the power system is identified on-line using a variable structure identifier. A feedback linearization-based control law is implemented using the identified model. The gains of the controller are tuned via a particle swarm optimization routine to ensure system stability and minimum sum of the squares of the speed deviations. A bench-mark problem of a 4-machine 2-area power system is used to demonstrate the performance of the proposed controller and to show its superiority over other conventional stabilizers used in the literature. ...

2010-12-15

445

CANMET's environmental and process research on uranium

OBJECTIVE To identify patients with gestational diabetes mellitus (GDM) who will need antenatal insulin treatment (AIT) by using a risk-prediction tool based on maternal clinical and biochemical characteristics at diagnosis. RESEARCH DESIGN AND METHODS Data from 3,009 women attending the Royal Prince Alfred Hospital GDM Clinic, Australia, between 1995 and 2010 were studied. A risk engine was developed from significant factors identified for AIT using a logistic regression model. RESULTS A total of 51% of GDM patients required AIT. Ethnicity, gestation at diagnosis, HbA(1c), fasting and 60-min glucose oral glucose tolerance test, BMI, and diabetes family history were significant independent determinants of AIT. Notably, only 9% of the attributable risk for AIT can be explained by the clinical factors studied. A modeled risk-scoring system was therefore a poor predictor of AIT. CONCLUSIONS Baseline maternal characteristics including HbA(1c) alone ...

2011-08-11

446

Assessing digital control system dependability using the dynamic flowgraph methodology

Environmental research related to uranium tailings is being carried out within the Mining Research Laboratories and Mineral Sciences Laboratories of CANMET, EMR. Field-related research on uranium tailings has been conducted at Elliot Lake for over five years. Much of the work has been focused on a program to rehabilitate pyritic tailings. This has resulted in developing a practicable technology for growing vegetation on such wastes. Limitations have been small size of the test-plots and the relatively short period during which experiments have been carried out. A research program aimed at identifying and reducing acidic and radioactive effluents is also underway at Elliot Lake. These liquid effluents have been identified as the most serious threat to the environment. Research at the Mineral Sciences Laboratories and its predecessor divisions relating to the processing of uranium and thorium ores is outlined. A process has been developed for ...

447

Americans' political participation in the 1993-94 national health care reform debate.

Dynamic Flowgraph Methodology (DFM) is a methodological approach to modeling and analyzing the behavior of software-driven embedded systems for the purpose of reliability/safety assessment and verification. The methodology has two fundamental goals: (a) to identify how certain postulated events may occur in a system and (b) to identify an appropriate testing strategy based on an analysis of system functional behavior. To achieve these goals, the methodology employs a modeling framework in which system models are developed in terms of causal relationships between physical variables and temporal characteristics of the execution of software modules. These models are then analyzed to determine how a certain state (desirable or undesirable) can be reached. This is done by developing timed fault trees, which take the form of logical combinations of static trees relating system parameters at different points in time. The prime implicants (multistate ...

1993-01-01

448

Adaptive PSS using a simple on-line identifier and linear pole-shift controller

The health politics and policy communities are still struggling with the question of "what went wrong" in the 1993-94 health care reform effort. Here I identify which Americans were politically active and inactive during the health care reform debate to explore the role political participation may have had in determining the outcome of the debate. Using data from a national and California random-sample telephone surveys, and controlling for other demographic attributes, I found that those who engaged in political activity specifically related to health care reform were disproportionately more likely to be self-identified conservatives, less likely to favor an employer mandate plan, more likely to be fifty to sixty-four years old, more likely to be men, and more likely to have greater interest in and knowledge of the health care issue. Even in California, where a single-payer proposal was on the November ballot, ...

1996-01-01

449

Safe ageing management of nuclear power plants: An European synthesis

Implementation of an adaptive power system stabilizer (APSS) and experimental studies are presented in this paper. The APSS consists of an adaptive linear element (ADALINE) based identifier that identifies the power system as a third-order discrete auto-regressive moving average (ARMA) model and a pole-shift controller. The ADALINE is modeled so that its weights have a one-to-one relationship with the ARMA model parameters. The weights are updated at each sampling interval to track the dynamic characteristics of the actual system. The on-line updated ARMA parameters are used in the PS control algorithm to calculate the new closed-loop poles of the system that are always inside the unit circle in the z-plane. The calculated control is such that it achieves regulation of the system to a constant setpoint in the shortest interval of time. Experimental studies on a physical model of power system verify that the proposed adaptive PSS effectively ...

2010-04-15

450

Working with activity theory: Context, technology, and information behavior

Ageing of nuclear power plants means evolution of material or equipment properties on one side, and evolution of personnel skill and procedure adequacy on the other side, both of which, after a certain time, may not be compatible with the required safety provisions, or with an economic operation of the plant. Repair or replacement of components, as well as change in service conditions for a better compatibility with component reduced capabilities can be used to mitigate ageing effects. The paper summarises the results of a study conducted in this field with the support of the European Commission. It presents: the synthesis of the work done under international auspices, and in the European context; the comparison of ageing management approaches used in several European countries with international recommendations; the summary of the various potential phenomena and their governing parameters, the methods of in-service ageing identification and possible mitigation methods; illustrative ...

2002-11-04

451

British Library Electronic Table of Contents (United Kingdom)

Abstract Over the last 7 years, the AIMTech Research Group in the University of Leeds has used cultural-historical activity theory (CHAT) to inform a range of research activities in the fields of information behavior and information systems. In this article, we identify certain openings and theoretical challenges in the field of information behavior, which sparked our initial interest in CHAT: context, technology, and the link between practice and policy. We demonstrate the relevance of CHAT in studying information behavior and addressing the identified openings and argue that by providing a framework and hierarchy of activity-action-operation and semantic tools, CHAT is able to overcome many of the uncertainties concerning information behavior research. In particular, CHAT provides resear...

2011-01-01

452

Volcanoscope: Scoping study for increasing resilience to hazards in volcanic regions

Environmental Research Database

ObjectivesProject VOLCANOSCOPE will evaluate strategies (1) for applying existing and new forecasting models to volcanic eruptions, and (2) for identifying methods to improve how forecasts are communicated effectively to vulnerable communities. To link forecasting and communication, the interdisciplinary study will assess how to engage all stakeholders - from monitoring scientists, through emergency agencies, to vulnerable communities - to optimize the understanding of forecasts among different end users. [continued...]DescriptionProject VOLCANOSCOPE will evaluate strategies (1) for applying existing and new forecasting models to volcanic eruptions, and (2) for identifying methods to improve how forecasts are communicated effectively to vulnerable communities. To link forecasting and communication, the interdisciplinary study will assess how to engage all stakeholders - from monitoring scientists, through emergency agencies, to vulnerable ...

2011-01-05

453

Transuranic radionuclides dispersed into the environment at accident sites, a bibliography

The hippo pathway in biological control and cancer development

The purpose of this project was to compile a bibliography of references containing environmental transuranic radionuclide data. The authors intent was to identify those parameters affecting transuranic radionuclide transport that may be generic and those that may be dependent on chemical form and/or environmental conditions. An understanding of the unique characteristics and similarities between source terms and environmental conditions relative to transuranic radionuclide transport and cycling will provide the ability to assess and predict the long term impact on man and the environment. An additional goal of the literature review, was to extract the ranges of environmental transuranic radionuclide data from the identified references for inclusion in a data base. Related to source term, these ranges of data can be used to calculate the dose to man from the radionuclides, and to perform uncertainty analyses on these dose assessments.

1994-07-01

454

British Library Electronic Table of Contents (United Kingdom)

Abstract The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis. Deregulation of the Hippo pathway is linked to cancer development. Its first core kinase Warts was identified in Drosophila more than 15 years ago, but it gained much attention when other core components of the pathway were identified 8 years later. Major discoveries of the pathway were made during past several years. The core kinase components Hippo, Salvador, Warts, and Mats in the fly and Mst1/2, WW45, Lats1/2, and Mob1 in mammals phosphorylate and inactivate downstream transcriptional co-activators Yorkie in the fly, Yes-associated protein (YAP) and transcriptional co-activator with ...

2011-01-01

455

Terahertz time-domain spectroscopy of atmospheric water vapor from 0.4 to 2.7 THz.

Summary of research on microbiological processes. International Energy Agency Subtask D, final report

We conducted broadband absorption measurements of atmospheric water vapor in the ground state, X {sup 1}A{sub 1} (000), from 0.4 to 2.7 THz with a pressure broadening-limited resolution of 6.2 GHz using pulsed, terahertz time-domain spectroscopy (THz-TDS). We measured a total of seventy-two absorption lines and forty-nine lines were identified as H{sub 2}{sup 16}O resonances. All the H{sub 2}{sup 16}O lines identified were confirmed by comparing their center frequencies to experimental values available in the literature.

2005-10-01

456

Summary of research on microbiological processes

Storage of thermal energy in aquifers has obvious benefits of saving energy and decreasing the consumption of fossil fuels. However, aquifer thermal energy storage (ATES), which involves groundwater aquifers as the storage medium for heat or chill, impinges on the environment. A literature review of pertinent microbiology publications (Hicks and Stewart, 1988) identified the potential for the interaction of ATES systems and microbiological processes to create a source of infectious diseases and the potential for damage to the environment. In addition, the review identified a potential for microbiological processes to develop conditions that would interfere with the operation of an ATES system. As a result of this research effort, investigators from Finland, Germany, Switzerland, and the United States have examined several ATES systems in operation and have observed that the ATES systems studied do not contribute to infectious disease ...

1992-09-01

457

Studies on the chemical composition and possible mechanisms underlying the antispasmodic and bronchodilatory activities of the essential oil of Artemisia maritima L.

Storage of thermal energy in aquifers has obvious benefits of saving energy and decreasing the consumption of fossil fuels. However, aquifer thermal energy storage (ATES), which involves groundwater aquifers as the storage medium for heat or chill, impinges on the environment. A literature review of pertinent microbiology publications (Hicks and Stewart, 1988) identified the potential for the interaction of ATES systems and microbiological processes to create a source of infectious diseases and the potential for damage to the environment. In addition, the review identified a potential for microbiological processes to develop conditions that would interfere with the operation of an ATES system. As a result of this research effort, investigators from Finland, Germany, Switzerland, and the United States have examined several ATES systems in operation and have observed that the ATES systems studied do not contribute to infectious disease ...

1992-09-01

458

British Library Electronic Table of Contents (United Kingdom)

This study describes the chemical composition of the essential oil of Artemisia maritima (Am.Oil) and the pharmacological basis for its medicinal use in gut and airways disorders. Twenty five compounds, composing 93.7% of the oil, were identified; among these, chrysanthenyl propionate and elixene were identified for the first time from any Artemisia species. The Am.Oil (0.3?1.0 mg/mL) suppressed spontaneous and high K+ (80 mM)-induced contractions in isolated rabbit jejunum, suggestive of an antispasmodic effect mediated possibly through calcium channel blockade. The calcium channel blockade activity was confirmed when pre-treatment of the tissue with Am.Oil (0.01?0.03 mg/mL) shifted the Ca++ concentration-response curves to the right, similar to verapamil and papaverine. In isolated trach...

2011-01-01

459

String Universality in Six Dimensions

Sensitivity analysis: Interaction of DOE SNF and packaging materials

In six dimensions, cancellation of gauge, gravitational, and mixed anomalies strongly constrains the set of quantum field theories which can be coupled consistently to gravity. We show that for some classes of six-dimensional supersymmetric gauge theories coupled to gravity, the anomaly cancellation conditions are equivalent to tadpole cancellation and other constraints on the matter content of heterotic/type I compactifications on K3. In these cases, all consistent 6D supergravity theories have a realization in string theory. We find one example which may arise from a novel string compactification, and we identify a new infinite family of models satisfying anomaly factorization. We find, however, that this infinite family of models, as well as other infinite families of models previously identified by Schwarz are pathological. We suggest that it may be feasible to demonstrate that there is a string theoretic realization of all consistent ...

2009-01-01

460

Selective dissolution and recovery of depleted uranium from armor plate. Final report, 26 June 1986-5 May 1987

A sensitivity analysis was conducted to evaluate the technical issues pertaining to possible destructive interactions between spent nuclear fuels (SNFs) and the stainless steel canisters. When issues are identified through such an analysis, they provide the technical basis for answering what if questions and, if needed, for conducting additional analyses, testing, or other efforts to resolve them in order to base the licensing on solid technical grounds. The analysis reported herein systematically assessed the chemical and physical properties and the potential interactions of the materials that comprise typical US Department of Energy (DOE) SNFs and the stainless steel canisters in which they will be stored, transported, and placed in a geologic repository for final disposition. The primary focus in each step of the analysis was to identify any possible phenomena that could potentially compromise the structural integrity of the canisters and to ...

1999-06-06

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Remedial investigation/feasibility study for the David Witherspoon, Inc., 901 Site, Knoxville, Tennessee: Volume 1

The impacted armor targets used in testing high density armor-piercing ammunition containing depleted uranium (DU) are subject to disposal as low-level radioactive waste. Because of the costs associated with disposal of the entire armor plate and the limited use of secured commercial sites in the future, the U.S. Army is seeking to identify and evaluate new technologies for decontaminating these armor plates. The objectives of this Phase I SBIR program are two-fold, namely: to develop a selective solvent that can decontaminate impacted armor targets containing DU for disposal or recycle, and to identify and characterize technologies that can remove depleted uranium from the solvent for solvent recycle and uranium recovery for easier hazardous-waste disposal.

1987-05-05

462

Proteomic analysis of apoptosis induction in human lung cancer cells by recombinant MVL

This remedial investigation (RI)/feasibility study (FS) supports the selection of remedial actions for the David Witherspoon, Inc. 901 Maryville Pike Site in Knoxville, Tennessee. Operations at the site, used as a recycling center, have resulted in past, present, and potential future releases of hazardous substances in to the environment. This Site is a Tennessee Superfund site. A phased approach was planned to (1) gather existing data from previous investigations managed by the Tenn. Dept. of Environment and Conservation; (2) perform a preliminary RI, including risk assessments, and an FS with existing data to identify areas where remedial action may be necessary; (3) gather additional field data to adequately define the nature and extent of risk-based contaminants that present identifiable threats to human and/or ecological receptors; and (4) develop remedial action alternatives to reduce risks to acceptable levels.

1996-10-01

463

British Library Electronic Table of Contents (United Kingdom)

Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic changes in A549 cells, and to identify the molecular pathways responsible for the anti-cancer action of R-MVL. We found that R-MVL induces A549 cells apoptosis in a dose-dependent manner by using MTT assay, fluorescent microscope (FM) and flow cytometry (FCM), and the IC50 was calculated to be 24.12??g/ml. Subsequently, 7 altered proteins in R-MVL-treated A549 cells were identified, including upregulated aldehyde dehydrogenase 1 and ?-actin, and five downregulated proteins: heat s...

2011-01-01

464

Proposals for the reporting of oil shale resources in Quennsland, Australia

Personal Information Databases

While no mine in Queensland has yet extracted shale oil economically, large resources of oil shale are known to occur throughout the State. These resources have been reported to the Queensland Department of Resource Industries (formerly the Department of Mines) according to a number of different parameters, using numerous methods of calculation and in some instances, detailed and comprehensive supporting information has not been provided. This paper outlines present methods of calculation and reporting of oil shale resources. A more uniform system of reporting resources of Queensland oil shale is desirable to enable an accountable and reliable estimate of resources to be made. It is intended that a code for the reporting of identified oil shale resources based on the present Australian codes for the reporting of identified mineral and coal resources be prepared, and that the importance of determining the level of confidence of resource ...

1990-09-01

465

Pectinolytic yeast isolates for cold-active polygalacturonase production

One of the most important aspects of security organization is to establish a framework to identify security significant points where policies and procedures are declared. The (information) security infrastructure comprises entities, processes, and technology. All are participants in handling information, which is the item that needs to be protected. Privacy and security information technology is a critical and unmet need in the management of personal information. This paper proposes concepts and technologies for management of personal information. Two different types of information can be distinguished: personal information and nonpersonal information. Personal information can be either personal identifiable information (PII), or nonidentifiable information (NII). Security, policy, and technical requirements can be based on this distinction. At the conceptual level, PII is defined and formalized by propositions over infons (discrete pieces of ...

2009-01-01

466

British Library Electronic Table of Contents (United Kingdom)

Pectin rich cold stored spoiled fruits, vegetables and cold soils were screened and different pectinolytic isolates were obtained by enrichment culturing and ruthenium red plate assay. Among the primary isolates 10-15% were yeast isolates. Six isolates with higher zones of pectin hydrolysis were selected and tested for polygalacturonase (PGU) production at room temperature (25 degrees C) and at 5 degrees C. One isolate identified as Saccharomyces sp. with highest polygalacturonase activity at 5 degrees C was used for enzyme production using raw fruit pectins as substrates. The isolate was identified by preliminary cultural, morphological and sugar fermentation tests. PGU production was high in raw pectin substrates like orange peel (21 U/ml), apple peel (20 U/ml ), mango peel (19 U/ml), ...

2011-01-01

467

Moving train loads identification on a continuous steel truss girder by using dynamic displacement influence line method

British Library Electronic Table of Contents (United Kingdom)

This paper presents a dynamic displacement influence line method for moving load identification on bridge. The finite element model of Poyang Lake continuous truss bridge-train systems is established and the dispersed modal shapes are acquired by modal analysis. Multi-axle moving train loads are identified with simulated annealing genetic algorithm by minimizing the errors between the measured displacements and the reconstructed displacements from the identified moving loads. In the identification process, the dynamic displacement influence line technique is used to calculate the time history displacement responses of the bridge to avoid solving equations of motion of the bridge repetitively. Several important parameters of the bridge-train system are discussed to investigate their effects...

2011-01-01

468

Moessbauer spectroscopic determination of chemical state of iron in bauxite

Mineral-wool industry: opportunities for natural gas technologies. Topical report, January-July 1987

The chemical state of iron contained in several kinds of bauxite, which are utilized as a raw material in the aluminum industry in Japan, were investigated by Moessbauer spectroscopy. The main compounds of iron were identified from the results, which showed variations of the Moessbauer absorption spectra with calcination and measuring temperature. Although the absorption intensities of the spectra differed significantly, major species identified were paramagnetic or superparamagnetic #alpha#-Fe_2O_3 in all of these bauxite samples. The superparamagnetic #alpha#-Fe_2O_3 was found mainly in the gibbsite-type bauxite, but not in the boehmite/gibbsite-type or the boehmite-type bauxite. The Moessbauer absorption spectra of red mud and its calcined products were also given. (author).

469

Materials for air turbines in wave power devices. A generic study

To quantify the opportunities for natural gas and identify technological advances needed to capture such opportunities, the mineral-wool industry was analyzed with respect to the principal companies, their capabilities, and markets. The mineral-wool industry is stable with a slightly declining market. Of its market segments, only commercial acoustic insulation (which is currently dominant) is likely to be affected by growth in the next ten years. The principal process is based on treatment of blast-furnace slags in a cupola furnace using coke as the fuel and reducing agent. Expanded use of gas, as a substitute for coke, would eliminate environmental problems and expand the latitude of suitable raw materials. The study provides insights into the mineral-wool industry and identifies factors that may constitute bases for future usage of natural gas.

1988-05-01

470

LMBFR and LWR in-core thermal-hydraulic codes: the state-of-the-art and research and development needs

Wave energy device teams have identified three varieties of air turbine as potentially applicable to wave energy devices. These are: conventional axial turbines; Wells, or self-rectifying, axial turbines and Francis turbines. This report examines the constructional requirements of these devices with regard to mechanical, environmental and manufacturing considerations. It is concluded that the major benefit of optimum material selection will be reduced manufacturing costs rather than enhanced turbine performance. A methodology of material selection has been established and candidate materials have been listed for the major components of each turbine type. Comparative costs for alternative materials are included, from which significant, potential economies have been identified. Recommendations are made aimed at achieving optimum material usage in the proposed turbines.

1981-01-01

471

Knowledge-Based Identification of the ERK2/STAT3 Signal Pathway as a Therapeutic Target for Type 2 Diabetes and Drug Discovery

A review of analytical design methods used for predicting reactor core flow and temperature distributions is presented with emphasis on LMFBR's. The paper also briefly describes and contrasts the methods used for LWR's. These methods are global analysis, subchannel analysis, distributed parameter, and hybrid analysis. The evolution of the local and subchannel analysis methods is presented. Data used for code validation are also presented. Current research and development needs are identified and discussed. Areas identified for future research and development include methods and expermental data for analysis of distorted bundles and natural convection. Methods that have been developed for predicting the safety performance of LMFBR's and LWR's are not within the scope of this paper.

1981-04-01

472

British Library Electronic Table of Contents (United Kingdom)

Many existing agents for diabetes therapy are unable to restore or maintain normal glucose homeostasis or prevent the eventual emergence of hyperglycemia-related complication. Therefore, agents based on novel mechanisms are sought to complement and extend the current therapeutic approaches. Based on the initial paper research, we focused on active STAT3 as an attractive pharmacological target for type 2 diabetes. The subsequent text mining with a unique query to identify suppressors but not activators of STAT3 revealed the ERK2/STAT3 pathway as a novel diabetes target. The description of ERK2 inhibitors as diabetes target had not been found in our text mining research at present. The mechanism-based peptide inhibitor for ERK2 was identified using the knowledge of the KIM sequence, which ha...

2011-01-01

473

Isolation and mapping of a polymorphic DNA sequence (pEFD64. 2) on chromosome 3 (D3S46)

Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder

A 4.0 kb TaqI fragment of cosmid EFD64 isolated by a HBV-3 oligonucleotide was subcloned into AccI site of pUC18. MspI identifies 5 allelic VNTR polymorphism with bands between 2.6 and 4.6 kb. RsaI, TaqI, EcoRI, BamHI, HindIII and PvuII identify the same VNTR polymorphism. With RsaI, 80% heterozygosity were observed in 80 unrelated Caucasians. This RFLP pEFD64.2 has been assigned to chromosome 3 by linkage analysis with loci (APOD) known to span this chromosome. Co-dominant segregation for the RsaI RFLP was observed in 40 three generation families. RFLPs were observed under the normal hybridization and washing condition.

1988-10-11

474

British Library Electronic Table of Contents (United Kingdom)

Background Identifying susceptibility genes for endophenotypes by studying analogous behaviors across species is an important strategy for understanding the pathophysiology underlying psychiatric disorders. This approach provides novel biological pathways plus validated animal models critical for selective drug development. One such endophenotype is avoidance behavior. Methods In the present study, novel automated registration methods for longitudinal behavioral assessment in home cages are used to screen a panel of recently generated mouse chromosome substitution strains that are very powerful in quantitative trait loci (QTL) detection of complex traits. In this way, we identified chromosomes regulating avoidance behavior (increased sheltering preference) independent of motor activity lev...

2009-01-01

475

High-Volume Centers

British Library Electronic Table of Contents (United Kingdom)

Outcome from trauma, surgery, and a variety of other medical conditions has been shown to be positively affected by providing treatment at facilities experiencing a high volume of patients with those conditions. An electronic literature search was made to identify English-language articles available through March 2011, addressing the effect of patient treatment volume on outcome for patients with subarachnoid hemorrhage. Limited data were identified, with 16 citations included in the current review. Over 60% of hospitals fall into the lowest case-volume quartile. Outcome is influenced by patient volume, with better outcome occurring in high-volume centers treating >60 cases per year. Patients treated at low-volume hospitals are less likely to experience definitive treatment. Furthermore, t...

2011-01-01

476

Genomic survey of prepulse inhibition in mouse chromosome substitution strains

British Library Electronic Table of Contents (United Kingdom)

Prepulse inhibition (PPI) is a measure of sensorimotor gating, a pre-attentional inhibitory brain mechanism that filters extraneous stimuli. Prepulse inhibition is correlated with measures of cognition and executive functioning, and is considered an endophenotype of schizophrenia and other psychiatric illnesses in which patients show PPI impairments. As a first step toward identifying genes that regulate PPI, we performed a quantitative trait locus (QTL) screen of PPI phenotypes in a panel of mouse chromosome substitution strains (CSSs). We identified five CSSs with altered PPI compared with the host C57BL/6J strain: CSS-4 exhibited decreased PPI, whereas CSS-10, -11, -16 and -Y exhibited higher PPI compared with C57BL/6J. These data indicate that A/J chromosomes 4, 10, 11, 16 and Y harbor...

2009-01-01

477

Genomic architecture of aggression: Rare copy number variants in intermittent explosive disorder

British Library Electronic Table of Contents (United Kingdom)

Abstract Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of aggression in which individuals act impulsively and grossly out of proportion from the involved stressors. Previous studies have identified genetic variants in the serotonergic pathway that play a role in susceptibility to this behavior, but additional contributors have not been identified. Therefore, to further delineate possible genetic influences, we investigated CNVs in individuals diagnosed with IED and/or personality disorder (PD). We carried out array comparative genomic hybridizati...

2011-01-01

478

Gear fault identification and classification of singular value decomposition based on Hilbert-Huang transform

British Library Electronic Table of Contents (United Kingdom)

An improved singular value decomposition method of gear fault identification based on Hilbert-Huang transform was proposed to overcome the problem of reconstructing a feature matrix of singular value decomposition. The method includes three steps. First, the instantaneous frequency and amplitude matrices were acquired by Hilbert-Huang transform from faulted gear signals. Second, after the matrices were decomposed by singular value decomposition, the defined distances of singular value vectors and the optimal threshold of the distance for classification were calculated. Third, the fault characteristics of a gearbox were identified and classified by the threshold of the distances. The result demonstrates that the proposed method effectively identifies the gear fault and can realize an automa...

2011-01-01

479

Gear crack level identification based on weighted K nearest neighbor classification algorithm

British Library Electronic Table of Contents (United Kingdom)

A crack fault is one of the damage modes most frequently occurring in gears. Identifying different crack levels, especially for early cracks is a challenge in gear fault diagnosis. This paper aims to propose a method to classify the different levels of gear cracks automatically and reliably. In this method, feature parameters in time domain, specially designed for gear damage detection and in frequency domain are extracted to characterize the gear conditions. A two-stage feature selection and weighting technique (TFSWT) via Euclidean distance evaluation technique (EDET) is presented and adopted to select sensitive features and remove fault-unrelated features. A weighted K nearest neighbor (WKNN) classification algorithm is utilized to identify the gear crack levels. The gear crack experime...

2009-01-01

480

Explosives detector

Evaluation of Reports on Environmental Measurements of Electromagnetic Fields Generated by High Voltage Transmission Lines and Substations

An apparatus for non-invasively inspecting an object, such as an item of luggage, for explosives material is described. It comprises a multi-channel thermal neutron inspection system having a plurality of neutron irradiation chambers. Simultaneous operation of several channels increases the maximum system throughput several times. Each chamber has a lithium neutron source which is stimulated to neutron production by a proton beam. Beam switching magnets are energised by pulsing to divert a common proton beam to each source in turn. The initial beam is generated by a radio frequency quadrupole accelerator. The advantages of this system are very low residual source activity and controllable neutron production thereby minimising safety hazards. The irradiation chamber may contain several different gamma ray detectors to identify the elements present in explosives material. In addition, a neutron radiography imaging means may be employed to ...

1991-10-02

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481

Energy savings opportunity survey. US Army Field Station Kunia, Oahu, Hawaii. Final report

This paper presents some situations, in which measurements of electromagnetic fields generated by transmission lines and substations should be performed. The range of measurements may differ, but maximum values of electric and magnetic fields and flux density must be identified in all situations. The area with electric field exceeding 1 kV/m should be identified as well. The author also presents basic requirements to be met by the measurement technique. These requirements are specified according to the national standard. Special attention should be paid to the identification of the spatial distribution of electric field and flux density generated in the vicinity of high voltage transmission lines. To verify the measurement results, it is necessary to calculate the distribution of both aforesaid field components. For environmental protection purposes, it is also proposed that the report should include measurements of electromagnetic fields of 50 ...

2007-01-01

482

Empirically defined subtypes of alcohol dependence in an Irish family sample

This Energy Savings Opportunity Survey (ESOS) is to identify Energy Conservation Opportunities (ECO`s) which are practical and economical for the reduction of energy consumption in accordance with the Army Facilities Energy Plan. The work to be performed under this project includes: (A) Coordinating with the on-going and proposed related projects. (B) Conducting a limited site survey required to identify applicable ECO`s and obtaining necessary data to evaluate the ECO`s. (C) Evaluating applicable ECO`s to determine their feasibility in accordance with current criteria. (D) Preparing programming and implementation documents for the recommended ECO`s. and (E) Preparing a comprehensive report to present the work performed including energy analysis, the results, and recommendations.

1989-06-01

483

British Library Electronic Table of Contents (United Kingdom)

Alcohol dependence (AD) is clinically and etiologically heterogeneous. The goal of this study was to explore AD subtypes among a sample of 1221 participants in the Irish Affected Sib Pair Study of Alcohol Dependence, all of whom met DSM-IV criteria for AD. Variables used to identify the subtypes included major depressive disorder, antisocial personality disorder, illicit drug dependence (cannabis, sedatives, stimulants, cocaine, opioids, and hallucinogens), nicotine dependence, the personality traits of neuroticism and novelty seeking, and early alcohol use. Using latent class analysis, a 3-class solution was identified as the most parsimonious description of the data. Individuals in a Mild class were least likely to have comorbid psychopathology, whereas a severe class had highest probabi...

2010-01-01

484

Dimensions and Latent Classes of Episodic Mania-Like Symptoms in Youth: An Empirical Enquiry

British Library Electronic Table of Contents (United Kingdom)

The dramatic increase in diagnostic rates of bipolar disorder in children and adolescents in the USA has led to an intense interest in the phenomenology of the disorder. Here we present data from a newly-developed instrument to assess episodic mania-like symptoms in youth in a large population-based sample (N?=?5326) using parent- and self-report. We found that a substantial proportion of children screened positive for having episodes of ?going high? and were at an increased risk for morbidity and impairment. Using factor analysis, we identified that episodic mania-like symptoms comprised two dimensions: An under-controlled dimension that was associated with significant impairment, and a low-risk exuberant dimension. Using latent class analysis, we identified a small group of children scor...

2011-01-01

485

Development of tooling suitable for stall regulated blades

Detection of Visual Deficits in Aging DBA/2J Mice by Two Behavioral Assays

The objectives of the project were to make significant improvements in the production of stall regulated blades in the areas of (a) the tip box, its housing, its mechanism and small GRP parts; (b) mould technology; (c) resins and glues and (d) root tooling. Although wood composite had been identified as a competitive technology for blades, compared with GRP blades, production volumes had been lower; reasons are given. The way in which the four areas identified for investigation were tackled are discussed. The study showed that the mould cycle time can be reduced to two days for a stall regulated blade and the blade quality can be improved by using the composite tip box and new resins. The time required for replication of moulds can be reduced by 40%.

2001-07-01

486

British Library Electronic Table of Contents (United Kingdom)

Purpose: The DBA/2J mice have been used as an animal model for human pigmentary glaucoma. However, these mice develop various degrees of disease symptoms at different ages, making it difficult to detect pathological changes of retinal degeneration at glaucoma onset. The purpose of this study is to develop a non-invasive assay to identify individual mice that develop visual deficits. Materials and Methods: We apply two behavioral tests, a swimming test of visual discrimination and a test of optomotor response, to identify glaucomatous DBA/2J mice. We then examine whether the elevation of intraocular pressure (IOP), the common risk factor for glaucoma, affects visual performances of the DBA/2J mice. We further compare the retinal ganglion cell death, one of the signature glaucoma symptoms, i...

2011-01-01

487

Defining the research agenda to reduce the joint burden of disease from Diabetes mellitus and Tuberculosis

British Library Electronic Table of Contents (United Kingdom)

Summary The steadily growing epidemic of diabetes mellitus poses a threat for global tuberculosis (TB) control. Previous studies have identified an important association between diabetes mellitus and TB. However, these studies have limitations: very few were carried out in low-income countries, with none in Africa, raising uncertainty about the strength of the diabetes mellitus-TB association in these settings, and many critical questions remain unanswered. An expert meeting was held in November 2009 to discuss where there was sufficient evidence to make firm recommendations about joint management of both diseases, to address research gaps and to develop a research agenda. Ten key research questions were identified, of which 4 were selected as high priority: (i) whether, when and how to sc...

2010-01-01

488

Cosmic ray antiproton/electron discrimination capability of the CAPRICE silicon-tungsten calorimeter using neural networks

Corrective measures evaluation work plan Technical Area V groundwater.

A data analysis based on an artificial neural network classifier is proposed to identify cosmic ray antiprotons detected with the CAPRICE silicon-tungsten imaging calorimeter against electron background in the energy range 1.2-4.0 GeV. A set of new physical variables, describing the events inside the calorimeter on the base of their different patterns, are introduced in order to discriminate between hadronic and electromagnetic showers. The ability of the artificial neural network classifier to perform a careful multidimensional analysis gives the possibility to identify antiprotons with an electron rejection 408{+-}85 (stat) at 95.0{+-}0.2 (stat)% of signal detection efficiency. The high accuracy achieved by this method improves substantially the efficiency in the evaluation of the cosmic ray antiproton spectrum. (orig.).

1996-11-01

489

Corrective measures evaluation work plan : Technical Area V Groundwater : revision 0.

This document, which is prepared as directed by the Compliance Order on Consent (COOC) issued by the New Mexico Environment Department, identifies and outlines a process to evaluate remedial alternatives to identify a corrective measure for the Sandia National Laboratories New Mexico Technical Area (TA)-V Groundwater. The COOC provides guidance for implementation of a Corrective Measures Evaluation (CME) for the TA-V Groundwater. This Work Plan documents an initial screening of remedial technologies and presents a list of possible remedial alternatives for those technologies that passed the screening. This Work Plan outlines the methods for evaluating these remedial alternatives and describes possible site-specific evaluation activities necessary to estimate remedy effectiveness and cost. These methods will be reported in the CME Report. This Work Plan outlines the CME Report, including key components and a description of the corrective ...

2004-04-01

490

Code Verification by the Method of Manufactured Solutions

This document, which is prepared as directed by the Compliance Order on Consent (COOC) issued by the New Mexico Environment Department, identifies and outlines a process to evaluate remedial alternatives to identify a corrective measure for the Sandia National Laboratories/New Mexico Technical Area (TA)-V Groundwater. The COOC provides guidance for implementation of a Corrective Measures Evaluation (CME) for the TA-V Groundwater. This Work Plan documents an initial screening of remedial technologies and presents a list of possible remedial alternatives for those technologies that passed the screening. This Work Plan outlines the methods for evaluating these remedial alternatives and describes possible site-specific evaluation activities necessary to estimate remedy effectiveness and cost. These methods will be reported in the CME Report. This Work Plan outlines the CME Report, including key components and a description of the corrective ...

2004-12-01

491

Body-and-cad Geometric Constraint Systems

A procedure for code Verification by the Method of Manufactured Solutions (MMS) is presented. Although the procedure requires a certain amount of creativity and skill, we show that MMS can be applied to a variety of engineering codes which numerically solve partial differential equations. This is illustrated by detailed examples from computational fluid dynamics. The strength of the MMS procedure is that it can identify any coding mistake that affects the order-of-accuracy of the numerical method. A set of examples which use a blind-test protocol demonstrates the kinds of coding mistakes that can (and cannot) be exposed via the MMS code Verification procedure. The principle advantage of the MMS procedure over traditional methods of code Verification is that code capabilities are tested in full generality. The procedure thus results in a high degree of confidence that all coding mistakes which prevent the equations from being solved correctly have been ...

2000-06-01

492

Body mass index and risk of colorectal cancer in Chinese Singaporeans

Motivated by constraint-based CAD software, we develop the foundation for the rigidity theory of a very general model: the body-and-cad structure, composed of rigid bodies in 3D constrained by pairwise coincidence, angular and distance constraints. We identify 21 relevant geometric constraints and develop the corresponding infinitesimal rigidity theory for these structures. The classical body-and-bar rigidity model can be viewed as a body-and-cad structure that uses only one constraint from this new class. As a consequence, we identify a new, necessary, but not sufficient, counting condition for minimal rigidity of body-and-cad structures: nested sparsity. This is a slight generalization of the well-known sparsity condition of Maxwell.

2010-01-01

493

British Library Electronic Table of Contents (United Kingdom)

AbstractBACKGROUND: The authors chose to examine the association between body mass index (BMI) and incident colorectal cancer across the spectrum of BMI, including underweight persons, because detailed prospective cohort data on this topic in Asians is scarce, as is data on underweight persons (BMI, <18.5 kg/m2) in any population. METHODS: Analysis of the Singapore Chinese Health Study included 51,251 men and women aged 45-74 years enrolled in 1993-1998 and followed through 2007. Incident cancer cases and deaths among cohort members were identified through record linkage, and 980 cases were identified. Cox regression models were used to investigate the association of baseline BMI with risk of incident colorectal cancer during a mean of 11.5 years of follow-up. RESULTS: A significant, U-sha...

2011-01-01

494

Activation of a multisensory, multifunctional nucleus in the zebrafish midbrain during diverse locomotor behaviors

British Library Electronic Table of Contents (United Kingdom)

Action potentials from the brain control the activity of spinal neural networks to produce, by as yet unknown mechanisms, a variety of motor behaviors. Particularly lacking are details on how identified descending neurons integrate diverse sensory inputs to generate specific locomotor patterns. We have examined the operations of the principal neurons in an intriguing midbrain nucleus, the nucleus of the medial longitudinal fasciculus (nMLF), in the larval zebrafish. The nMLF is the most rostral grouping of neurons that projects from the brain well into the spinal cord of teleost fishes, yet there is little direct physiological data available regarding its function. We report here that a distinct set of large, individually-identifiable neurons in nMLF (the MeL and MeM neurons) are activated...

2010-01-01

495

A single-institution review of 157 patients presenting with benign and malignant tumors of the ampulla of Vater: Management and outcomes

British Library Electronic Table of Contents (United Kingdom)

BackgroundAlthough benign ampullary tumors are removed endoscopically, due to their potential to progress to malignant disease, the favored treatment for adenocarcinoma is pancreaticoduodenectomy. We reviewed our institutions experience in order to identify which patients were at highest risk of disease progression following surgical resection, as well as evaluate whether localized T1 tumors are best treated by pancreaticoduodenectomy. MethodsWe retrospectively reviewed 157 patients who presented with an ampullary mass, from 2001 to 2010, and identified 51 with benign adenoma and 106 with adenocarcinoma. ResultsPatients with malignant tumors most often presented with larger tumors and jaundice, which alone was predictive of survival (OR = 67). Forty-five percent of patients with pathologic...

2011-01-01

496

A new approach to the isolation and characterization of wheat flour allergens

British Library Electronic Table of Contents (United Kingdom)

Summary Background The incidence of food allergy to wheat is increasing. Its diagnosis depends on the purity of major allergens and their inclusion in tests. Isolation and characterization of wheat allergens are therefore of utmost importance. Objective To purify and identify wheat flour allergens most frequently recognized by patients' IgE antibodies and to study their allergenicity. Methods Water/salt-soluble extracts from wheat flour were prepared and separated using a combination of ultrafiltration, isoelectric focusing and liquid chromatography. Purified proteins were analysed by immunoblotting using pooled sera from patients with atopic dermatitis who possessed IgE specific to wheat. Wheat proteins found to bind IgE were subsequently identified by matrix-assisted laser desorption/ion...

2011-01-01

497

A neuro power system stabilizer based on adaptive control technique