Science.gov (United States)

Four-enzyme section of the shikimate pathway (Aro B, D, E, and K) of Streptococcus pneumoniae has been studied. Kinetic properties of the individual enzymes and three- and four-enzyme linked reactions have been characterized in vitro. On the basis of the data measured in spectrophotometric and LC-MS experiments, kinetic mechanisms of the enzymes have been suggested and all kinetic parameters have been identified. Kinetic models for these three- and four-enzyme sections of the shikimate pathway have been constructed and validated. The model of the four-enzyme section of shikimate pathway has been employed to design an inhibition-sensitive reconstituted pathway for a high-throughput screening effort on the shikimate pathway. It was demonstrated that using the model it was possible to optimize this reconstituted pathway in such a way to provide ...

UK PubMed Central (United Kingdom)

Temperature sensing is crucial for homeotherms, including human beings, to maintain a stable body core temperature and respond to the ambient environment. A group of exquisitely temperature-sensitive...Full Text Available

UK PubMed Central (United Kingdom)

The identification of predictive biomarkers is at the core of modern toxicology. So far, a number of approaches have been proposed. These rely on statistical inference of toxicity response from either...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

As part of studies into the siting of a deep repository for nuclear waste, Swedish Nuclear Fuel and Waste Management Company (SKB) has commissioned the Alternative Models Project (AMP). The AMP is a comparison of three alternative modeling approaches for geosphere performance assessment for a single hypothetical site. The hypothetical site, arbitrarily named Aberg is based on parameters from the Aespoe Hard Rock Laboratory in southern Sweden. The Aberg model domain, boundary conditions and canister locations are defined as a common reference case to facilitate comparisons between approaches. This report presents the results of a discrete fracture pathways analysis of the Aberg site, within the context of the SR 97 performance assessment exercise. The Aberg discrete fracture network (DFN) site model is based on consensus Aberg parameters related to the Aespoe HRL site. Discrete fracture pathways are identified from canister ...

UK PubMed Central (United Kingdom)

Autophagy is an evolutionarily conserved degradative pathway that has been implicated in a number of physiological events important for human health. This process was originally identified as a response...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The shrinking core model is examined for gas-solid noncatalytic reactions with a self-inhibited rate form and it is shown that multiple reaction pathways are possible for solid particles reacted under identical conditions. The observed reaction rate can have up to two discontinuities (jumps) during reaction for particles of spherical and cylindrical shape. The geometric instability analysis reveals that the reaction interface is stable under a very limited set of conditions only for solid particles of slab geometry. For a sphere or cylinder at large Biot numbers the reaction interface is always potentially unstable. This model provides a plausible explanation for gas-solid reactions which exhibit erratic shrinking core behavior.

Science.gov (United States)

African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more productive Bos indicus zebu breeds are much more susceptible. Zebu cattle are well adapted for plowing and haulage, and increasing their tolerance of trypanosomiasis could have a major impact on crop cultivation as well as dairy and beef production. We used three strategies to obtain short lists of candidate genes within QTL that were previously shown to regulate response to infection. We analyzed the transcriptomes of trypanotolerant N'Dama and susceptible Boran cattle after infection with Trypanosoma congolense. We sequenced EST libraries from these two breeds to identify polymorphisms that might underlie previously identified quantitative trait loci (QTL), and we assessed QTL regions and candidate loci for evidence of selective ...

British Library Electronic Table of Contents (United Kingdom)

This study examined the life histories of a group of emerging scholars in the field of mathematics education who identify themselves as having a particular interest in and concern for issues of equity and diversity. Experiences of being the "other," "bearing witness" to "othering experiences," and "orienting experiences" in relation to issues of equity proved to be prominent themes in participants' life histories. These experiences were then linked to the positionality that these scholars now have in relation to their research in mathematics education.

British Library Electronic Table of Contents (United Kingdom)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly accounting for the vast majority of dementia. Recently, many studies have implicated the role of inflammatory response, especially neuroinflammatory response in the development and progression of AD. However, the underlying mechanism of how inflammatory response induces AD is unknown. Kynurenine pathway is a major route of the amino acid tryptophan catabolism, resulting in the production of nicotine adenine dinucleotide and other neuroactive intermediates: quinolinic acid (QA) and kynurenic acid (KA). QA exerts different toxic effects, including over-activation of N-methyl-d-aspartate (NMDA) receptor and excitotoxicity, synaptic dysfunction and neuronal death. On the other hand, KA is identified as the only...

Energy Technology Data Exchange (ETDEWEB)

A core competency is a distinguishing integration of capabilities which enables an organization to deliver mission results. Core competencies represent the collective learning of an organization and provide the capacity to perform present and future missions. Core competencies are distinguishing characteristics which offer comparative advantage and are difficult to reproduce. They exhibit customer focus, mission relevance, and vertical integration from research through applications. They are demonstrable by metrics such as level of investment, uniqueness of facilities and expertise, and national impact. The Oak Ridge National Laboratory (ORNL) has identified four core competencies which satisfy the above criteria. Each core competency represents an annual investment of at least $100M and is characterized by an integration of Laboratory technical foundations in ...

Energy Technology Data Exchange (ETDEWEB)

A review of analytical design methods used for predicting reactor core flow and temperature distributions is presented with emphasis on LMFBR's. The paper also briefly describes and contrasts the methods used for LWR's. These methods are global analysis, subchannel analysis, distributed parameter, and hybrid analysis. The evolution of the local and subchannel analysis methods is presented. Data used for code validation are also presented. Current research and development needs are identified and discussed. Areas identified for future research and development include methods and expermental data for analysis of distorted bundles and natural convection. Methods that have been developed for predicting the safety performance of LMFBR's and LWR's are not within the scope of this paper.

British Library Electronic Table of Contents (United Kingdom)

Background Identifying susceptibility genes for endophenotypes by studying analogous behaviors across species is an important strategy for understanding the pathophysiology underlying psychiatric disorders. This approach provides novel biological pathways plus validated animal models critical for selective drug development. One such endophenotype is avoidance behavior. Methods In the present study, novel automated registration methods for longitudinal behavioral assessment in home cages are used to screen a panel of recently generated mouse chromosome substitution strains that are very powerful in quantitative trait loci (QTL) detection of complex traits. In this way, we identified chromosomes regulating avoidance behavior (increased sheltering preference) independent of motor activity lev...

British Library Electronic Table of Contents (United Kingdom)

Mutations or multiplications in a-synuclein gene cause familial forms of Parkinson disease or dementia with Lewy bodies (LB), and the deposition of wild-type a-synuclein as LB occurs as a hallmark lesion of these disorders, collectively referred to as synucleinopathies, implicating a-synuclein in the pathogenesis of synucleinopathy. To identify modifier genes of a-synuclein-induced neurotoxicity, we conducted an RNAi screen in transgenic C. elegans (Tg worms) that overexpress human a-synuclein in a pan-neuronal manner. To enhance the RNAi effect in neurons, we crossed a-synuclein Tg worms with an RNAi-enhanced mutant eri-1 strain. We tested RNAi of 1673 genes related to nervous system or synaptic functions, and identified 10 genes that, upon knockdown, caused severe growth/motor abnormalit...

International Nuclear Information System (INIS)

An on-going inter-comparison programme which is focused on assessing and establishing consensus protocols to be applied in the identification, selection and sub-sampling of materials for subsequent "1"4C analysis is described. The outcome of the programme will provide a detailed quantification of the uncertainties associated with "1"4C measurements including the issues of accuracy and precision. Such projects have become recognised as a fundamental aspect of continuing laboratory quality assurance schemes, providing a mechanism for the harmonisation of measurements and for demonstrating the traceability of results. The design of this study and its rationale are described. In summary, a suite of core samples has been defined which will be made available to both AMS and radiometric laboratories. These core materials are representative of routinely dated material and their ages span the full range of the applied "1"4C time-scale. Two of the ...

Energy Technology Data Exchange (ETDEWEB)

During the last years, boron dilution events with the potential of reactivity transients were an important issue of German PWR safety analyses. A coolant with a low-boron concentration could be collected in localized areas of the reactor coolant system, e.g., by separation of a borated reactor coolant into highly concentrated and diluted fractions (inherent dilution) which can occur during reflux-condenser heat transfer after a small break loss of coolant accident with a limited availability of the emergency core cooling systems. During the course of follower core assessments, TUV NORD SysTec appraises safety analyses of boron dilution events presented by the utilities. These analyses are based on the simulation of boron dilution and transport processes in conjunction with a number of dedicated experiments. The analyses demonstrate that boron dilution events cannot lead to recriticality of the core. Hence, the boron ...

Energy Technology Data Exchange (ETDEWEB)

Tissue factor pathway inhibitor (TFPI), a protease inhibitor that circulates in association with plasma lipoproteins (VLDL, LDL and HDL), helps to regulate the extrinsic blood coagulation cascade. The authors have cloned a 125-kb genomic region containing the entire human TFPI gene on six overlapping cosmids and prepared a restriction map of this contig to clarify gene structure. More than half (45 kb) of the 85-kb gene is occupied with 5[prime] noncoding elements: coding begins at exon 3. A HindIII RFLP identified with one cosmid was genotyped in the CEPH panel of 559 reference families. Linkage analysis using markers on human chromosome 2 located the TFPI gene on 2q, 36 cM proximal to D2S43(pYNZ15) and 13 cM distal to the crystalline [gamma]-polypeptide locus CRYGP1(p5G1). 31 refs., 3 figs., 3 tabs.

Energy Technology Data Exchange (ETDEWEB)

The YGN Units 3 and 4 plant conditions during shutdown operation were reviewed to identify the possible event scenarios following the loss of shutdown cooling. The thermal hydraulic analyses were performed for the five cases of RCS configurations under the worst event scenario, unavailable secondary cooling and no RCS inventory makeup, using the RELAP5/MOD3.2 code to investigate the plant behavior. From the analyses results, times to boil, times to core uncovery and times to core heat up were estimated to determine the containment closure time to prevent the uncontrolled release of fission products to atmosphere. These data provide useful information to the abnormal procedure to cope with the event. 6 refs., 7 figs., 2 tabs. (Author)

Energy Technology Data Exchange (ETDEWEB)

During the last years one focus of German PWR safety analysis was boron dilution events with the potential of reactivity transients. Coolant with a low boron concentration could be collected in localized areas of the reactor coolant system e.g. by separation of borated reactor coolant into highly concentrated and diluted fractions (inherent dilution) which can occur during reflux- condenser heat transfer after a small break loss of coolant accident with a limited availability of the emergency core cooling systems. The TUeV NORD SysTec was charged by German supervisory authorities with the assessment of the safety analyses of boron dilution events presented by the utilities. These analyses are based on the simulation of boron dilution and transport processes in conjunction with a number of dedicated experiments. The analyses shall demonstrate that boron dilution events cannot lead to recriticality of the core. Hence the boron concentration at ...

International Nuclear Information System (INIS)

The massive star-forming core MM1 of W75N was observed using the Submillimeter Array with #approx#1'' and 2'' spatial resolutions at 217 and 347 GHz, respectively. From the 217 GHz continuum we found that the MM1 core consists of two sources, separated by about 1'': MM1a (#approx#0.6 M_s_u_n) and MM1b (#approx#1.4 M_s_u_n), located near the radio continuum sources VLA 2/VLA 3 and VLA 1, respectively. Within MM1b, two gas clumps were found to be expanding away from VLA 1 at about #+-#3 km s"-"1, as a result of the most recent star formation activity in the region. Observed molecular lines show emission peaks at two positions, MM1a and MM1b: sulfur-bearing species have emission peaks toward MM1a, but methanol and saturated species at MM1b. We identified high-temperature (#approx#200 K) gas toward MM1a and the hot core in MM1b. This segregation may result from the evolution of the massive star-forming ...

British Library Electronic Table of Contents (United Kingdom)

Drosophila melanogaster is a model organism rich in genetic tools to manipulate and identify neural circuits involved in specific behaviors. Here we present a technique for two-photon calcium imaging in the central brain of head-fixed Drosophila walking on an air-supported ball. The ball's motion is tracked at high resolution and can be treated as a proxy for the fly's own movements. We used the genetically encoded calcium sensor, GCaMP3.0, to record from important elements of the motion-processing pathway, the horizontal-system lobula plate tangential cells (LPTCs) in the fly optic lobe. We presented motion stimuli to the tethered fly and found that calcium transients in horizontal-system neurons correlated with robust optomotor behavior during walking. Our technique allows both behavior ...

Energy Technology Data Exchange (ETDEWEB)

The scope of this RA is limited to the evaluation of potential human health risks associated with a failure event of a tank containing Basin F liquid. Section 1.0 contains an introduction to the health risk assessment. Section 2.0 describes the site history, location, and land use. Section 3.0 provides a brief description of exposure pathways and potention receptors. Section 4.0 describes the sources of data used and identifies chemicals of concern. Section 5.0 discusses the toxicity of concern. Section 6.0 explains the methods used for calculation of carcinogenic risks and the noncarcinogenic hazard indexes. Section 7.0 describes uncertainties inherent in the current methodology used to determine potential human health risks. Section 8.0 presents a summary of results and conclusions. Section 9.0 includes the references cited.

Energy Technology Data Exchange (ETDEWEB)

A detailed chemical kinetic reaction mechanism is developed to describe incineration of the chemical warfare nerve agent sarin (GB), based on commonly used principles of bond additivity and hierarchical reaction mechanisms. The mechanism is based on previous kinetic models of organophosphorus compounds such as TMP, DMMP and DIMP that are often used as surrogates to predict incineration of GB. Kinetic models of the three surrogates and GB are then used to predict their consumption in a perfectly stirred reactor fueled by natural gas to simulate incineration of these chemicals. Computed results indicate that DIMP is the only one of these surrogates that adequately describes combustion of GB under comparable conditions. The kinetic pathways responsible for these differences in reactivity are identified and discussed. The most important reaction in GB and DIMP that makes them more reactive than TMP or DMMP is found to be a six-center molecular ...

Energy Technology Data Exchange (ETDEWEB)

A magnetic tape consisting of oil-shale Fischer assay data for selected well cores in the Piceance Creek Basin was prepared as a supplement to NTIS tape PB-230 607/AS. Both tapes serve as a data base for calculating oil-shale resources (Pitman, 1981). The tape is in standard IBM format and has the following specifications: EBCDIC (IBM standard), card-image, blocksize 1720 (blocked 20 to 1), record length 86, odd parity, 1,600 bpi, 9-track, no label tape. Each data file on the tape consists of records containing oil-shale analyses for one well core. The first record in a data file consists of a well-core identifier which is a three-digit number preceded by the character 'C'. The second record contains the well name and location, and the remaining records contain Fischer assay data.

Energy Technology Data Exchange (ETDEWEB)

The Idaho National Laboratory (INL) Ten-Year Site Plan (TYSP) describes the strategy for accomplishing the long-term objective of transforming the laboratory to meet Department of Energy (DOE) national nuclear research and development (R&D) goals, as outlined in DOE strategic plans. The plan links R&D mission goals and INL core capabilities with infrastructure requirements (single- and multi-program), establishs the 10-year end-state vision for INL complexes, and identifies and prioritizes infrastructure needs and capability gaps. The TYSP serves as the basis for documenting and justifying infrastructure investments proposed as part of the FY 2013 budget formulation process.

J-STORE (Japan)

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International Nuclear Information System (INIS)

Besides differentiation and apoptosis, cell migration is a basic process in brain development in which neural cells migrate several centimeters within the developing brain before reaching their proper positions and forming the right connections. For identifying signaling events that control neural migration and are therefore potential targets of chemicals to disturb normal brain development, we developed a human neurosphere-based migration assay based on normal human neural progenitor (NHNP) cells, in which the distance is measured that cells wander over time. Applying this assay, we investigated the role of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the regulation of NHNP cell migration. Exposure to model substances like ethanol or phorbol 12-myristate 13-acetate (PMA) revealed a correlation between ERK1/2 activation and cell migration. The participation of phospho-(P-) ERK1/2 was confirmed by exposure of the cells to the MEK inhibitor PD98059, ...

UK PubMed Central (United Kingdom)

The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood. With a clear understanding...Full Text Available

Norwegian Open Research Archives (NORA)

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Energy Technology Data Exchange (ETDEWEB)

The NGDRS has facilitated 85% of cores, cuttings, and other data identified available for transfer to the public sector. Over 12 million linear feet of cores and cuttings, in addition to large numbers of paleontological samples and are now available for public use. To date, with industry contributions for program operations and data transfers, the NGDRS project has realized a 6.5 to 1 return on investment to Department of Energy funds. Large-scale transfers of seismic data have been evaluated, but based on the recommendation of the NGDRS steering committee, cores have been given priority because of the vast scale of the seismic data problem relative to the available funding. The rapidly changing industry conditions have required that the primary core and cuttings preservation strategy evolve as well. Additionally, the NGDRS clearinghouse is evaluating the viability of transferring ...

International Nuclear Information System (INIS)

An overall plant design was developed for a gas-cooled fast reactor employing a direct supercritical Brayton power conversion system. The most important findings were that (1) the concept could be capital-cost competitive, but startup fuel cycle costs are penalized by the low core power density, specified in large part to satisfy the goal of significant post-accident passive natural convection cooling; (2) active decay heat removal is preferable as the first line of defense, with passive performance in a backup role; (3) an innovative tube-in-duct fuel assembly, vented to the primary coolant, appears to be practicable; and (4) use of the S-Co2 GFR to support hydrogen production is a synergistic application, since sufficient energy can be recuperated from the product H2 and 02 to allow the electrolysis cell to run 250 C hotter than the reactor coolant, and the water boilers can be used for reactor decay heat removal. Increasing core power ...

Energy Technology Data Exchange (ETDEWEB)

A considerable amount of chemical knowledge of marine sediments has been acquired in recent years but has not yet been utilized by paleomagnetists. On the other hand, geochemists are often unaware of the usefulness of numerous magnetic techniques. In this review we try to bridge this gap, and in particular, we outline many of the chemical and magnetic principles that should allow paleomagnetists to better identify and undertand chemical changes that affect the magnetic properties of marine sediments. The chemical principles include those for distinguishing the four major sources of sediments (continental, biological, authigenic/hydrogenous, volcanic/hydrothermal) from one another by determining elemental abundance distributions, as well as for investigating the stabilities of mineral phases relative to changes in pE and pH. The magnetic principles include the effects of authigenesis and diagenesis on magnetic properties, particularly on the direction and intensity ...

CERN Document Server

(abridged) Observations clearly show that low-mass AGB stars can provide a nucleosynthesis site of the s-process. Recent stellar evolution models indicate that radiative burning of C13 between thermal pulses in low-mass AGB stars may indeed provide the needed neutrons. Some mixing between the proton-rich envelope and the carbon-rich core may lead to the production of C13. However, the responsible physical mechanism is not yet unambiguously identified. We present stellar model calculations with overshoot and rotation. Overshoot, with a time-dependent and exponentially decaying efficiency, leads to a partial mixture of protons and C12 during the third dredge-up. According to the depth-dependent ratio of protons and C12, a small C13-pocket forms underneath a N14-rich layer. Overshoot does not allow for any mixing during the interpulse phase. Rotation introduces mixing driven by large angular velocity gradients which form at the ...

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The response of Desulfovibrio vulgaris Hildenborough (DvH),a sulphate-reducing bacterium, to nitrate stress was examined usingquantitative proteomic analysis. DvH was stressed with 105 m M sodiumnitrate(NaNO3), a level that caused a 50 percent inhibition in growth.The protein profile of stressed cells was compared with that of cellsgrown in the absence of nitrate using the iTRAQ peptide labellingstrategy and tandem liquid chromatography separation coupled with massspectrometry (quadrupoletime-of-flight) detection. A total of 737 uniqueproteins were identified by two or more peptides, representing 22 percentof the total DvH proteome and spanning every functional category. Theresults indicate that this was a mild stress, as proteins involved incentral metabolism and the sulphate reduction pathway were unperturbed.Proteins involved in the nitrate reduction pathway increased. Increasesseen in transport systems for proline, ...

Energy Technology Data Exchange (ETDEWEB)

A core preservation package was developed to maintain the reservoir characteristics of core samples and consequently to improve the quality of data obtained through laboratory core analyses. The package is a heat-sealable plastic-aluminum laminate similar to those common in the food-packaging industry. The laminated core preservation package acts as an impermeable barrier to water vapor and gases, and is resistant to chemical alteration and degradation by core fluids. These performance characteristics result in effective core preservation by maintaining the fluid content of the core. Other advantages of the laminated package are that it is fast and simple to use and eliminates the cumbersome dip-coat step used in some core preservation methods.

Energy Technology Data Exchange (ETDEWEB)

An overview is provided of an evolving atomistic and kinetic model of semiconductor growth that unifies the main features of strain relaxation in low and high lattice misfit heteroepitaxy. The model reveals a kinetic pathway for dislocation formation during growth with little or no energy cost at low misfits, thus providing a way out of the longstanding dilemma of too high dislocation nucleation energies predicted by classical theories of the equilibrium behavior of a fixed number of particles at low misfits. The essential kinetic process underlying the model are identified on the basis of comparison of the predictions of kinetic Monte-Carlo simulations of growth with real-time or in-situ data obtained in such experiments as reflection high-energy electron diffraction (RHEED) and scanning probe microscopy (SPM). Relative significance of these atomistic kinetic processes is shown to naturally lead to strain relaxation via defect initiation at ...

British Library Electronic Table of Contents (United Kingdom)

Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of recessive PD. Autophagy, a pathway for clearance of protein aggregates or impaired organelles, is a newly identified mechanism for PD development. However, it is still unclear what molecules regulate autophagy in PINK1-silenced cells. Here we report that autophagosome formation is promoted in the early phase in response to PINK1 gene silencing by lentivirus transfer vectors expressed in mouse striatum. Reduced PP2A activity and increased phosphorylation of PP2A at Y307 (inactive form of PP2A) were observed in PINK1-knockdown dopaminergic cells and striatum tissues. Treatment with C2-ceramide (an agonist of PP2A) reduced autophagy levels in PINK...

International Nuclear Information System (INIS)

This paper addresses the quantification of human exposure to volatile organic compounds (VOC's) as a result of mass transfer from tap water to indoor air. A three-compartment model is developed and used to simulate the 24-h concentration profile within the shower, bathroom, and remaining household volumes of a dwelling. Mass transfers from water to air are derived from measured data for radon and adjusted to account for the difference in mass-transfer properties for VOC's. A preliminary data base for household parameters is used to calculate a range of concentrations and human exposures in U.S. dwellings. The model is used to estimate exposure factors for seven compounds-chloroform, ethylene dibromide, dibromo-chloropropane, methylchloroform, perchloroethylene, trichloroethylene, and carbon tetrachloride. The calculated ratio of indoor-air exposure to tap water concentration is compared to measured values for one of the compounds, chloroform. A sensitivity analysis is used to ...

Science.gov (United States)

Chlorinated organics are frequently found as harmful soil contaminants and persisted for extended periods of time. A novel approach, named pulsed corona discharge plasma (PCDP), was employed for the degradation of pentachlorophenol (PCP) in soil. Experimental results showed that 87% of PCP could be smoothly removed in 60 min. Increasing pulse voltage, enhancing soil pH, lowering humic acid (HA) in soil and reducing granular size of the soil were found to be favorable for PCP degradation efficiency. Oxidation and physical processes simultaneously contributed to PCP removal in soil and ozone was the main factor in PCDP treatment. C-Cl bonds in PCP were cleaved during PCDP treatment by Fourier transform infrared spectroscopy (FTIR) analysis. The mineralization of PCP was confirmed by total organic carbon (TOC) and dechlorination analyses. The main intermediate products such as tetrachlorocatechol, tetrachlorohydroquinone, acetic acid, formic acid, and oxalic acid were ...

Energy Technology Data Exchange (ETDEWEB)

Managing sites contaminated with munitions constituents is an international challenge. Although the choice of approach and the use of Ecological Risk Assessment (ERA) tools may vary from country to country, the assurance of quality and the direction of ecotoxicological research are universally recognized as shared concerns. Drawing on a multidisciplinary team of contributors, 'Ecotoxicology of Explosives' provides comprehensive and critical reviews available to date on fate, transport, and effects of explosives. The book delineates the state of the science of the ecotoxicology of explosives, past, present, and recently developed. It reviews the accessible fate and ecotoxicological data for energetic materials (EMs) and the methods for their development. The chapters characterize the fate of explosives in the environment, then provide information on their ecological effects in key environmental media, including aquatic, sedimentary, and terrestrial habitats. The book ...

British Library Electronic Table of Contents (United Kingdom)

The prevention of subscriber churn through customer retention is a core issue of Customer Relationship Management (CRM). By minimizing customer churn a company maximizes its profit. This paper proposes a hybridized architecture to deal with customer retention problems. It does so not only through predicting churn probability but also by proposing retention policies. The architecture works in two modes: learning and usage.In the learning mode, the churn model learner seeks potential associations from the subscriber database. This historical information is used to form a churn model. This mode also calls for a policy model constructor to use the attributes identified in the churn model to divide all `churners' into distinct groups. The policy model constructor is also responsible for develop...

Energy Technology Data Exchange (ETDEWEB)

An expert system was developed which helps maintenance personnel diagnose the condition of rotor and stator windings and their cores, in motors and generators rated 2300 V and above. The expert system, called MICAA[TM], used an approach which has been found to be effective for diagnosing medical problems. The program required the user to input machine nameplate information, operating status, and any past test data available. In addition, the program would suggest tests that may be useful, as well as provide guidance to maintenance personnel on what to look for in visual inspections of the machine. The expert system stored and correlated all this information, calculated the overall condition of the component in question, and identified the most likely specific causes of any deterioration. The basic methodology of motor and generator condition assessment, and the architecture and processing performed by MICAA to obtain these capabilities were ...

Energy Technology Data Exchange (ETDEWEB)

Inverse and direct methods have been used to analyze a large number of borehole temperature logs in order to infer past climatic changes. Results indicate a warming of 1-2[degree]C in eastern and central Canada during the past 150 years. A period of cooling between 500 and 200 years before present, corresponding to the time of the Little Ice Age, has also been identified in the same areas. A regional ground temperature history is estimated for eastern and central Canada from the simultaneous inversion of several temperature logs. The inferred temperature changes appear correlated with the concentration of atmospheric carbon dioxide as reported from a Greenland ice core, and agree with existing meteorological and dendrochronological records for the area.

British Library Electronic Table of Contents (United Kingdom)

The primary goal of this study was to assess the association between the full birth weight distribution and prevalence of specific developmental disabilities and related measures of health and special education services utilization in US children. Using data from the 1997?2005 National Health Interview Survey (NHIS) Sample Child Core, we identified 87,578 children 3?17?years of age with parent-reported information on birth weight. We estimated the prevalences of DDs (attention-deficit/hyperactivity disorder [ADHD], autism, cerebral palsy, hearing impairment, learning disability without mental retardation, mental retardation, seizures, stuttering/stammering, and other developmental delay) and several indicators of health services utilization within a range of birth weight categories. We cal...

Science.gov (United States)

This paper focuses on a factorial-based design strategy. The approach provides an efficient and statistically reliable means for assessing the influence of multivariable effects. It is applied to the detection and evaluation of damage in impacted composite sandwich panels. The experimental results obtained from this test strategy are utilized to form an empirical response function. The resulting polynomial relates damage area to residual compression strength at values of independent variables for which testing did not occur. The response function also identifies nonlinear interaction effects of key variabes that cannot be easily ascertained by traditional single-variable test strategies. Independent variables evaluated include core thickness, number of face sheet plys and impact energy. The methodology presented allows the designer to predict with more confidence the damage tolerance of a composite material component, and the analyst to more ...

International Nuclear Information System (INIS)

Recognizing the importance of energy as a vital component in economic development, the Taiwanese government has been continuously revising its energy policy, seeking to balance economic development, energy supply, and environmental protection (3E). Some measures, in an attempt to achieve the 3E balance, were previously implemented in Taiwan; nevertheless, some unresolved issues departing from certain core principles of Taiwan's sustainable energy policy and an international initiative for a low carbon society remain. The aim of this paper is to examine the energy supply and demand structure of Taiwan and the present status of individual energy carriers (including coal, petroleum, natural gas and electricity). In addition, it investigates the current energy policy framework and its implementation in Taiwan, identifies unresolved issues regarding sustainable energy development, and formulates key policy solutions for certain ...

Science.gov (United States)

This report covers the initial DARPA DTN Phase 3 activities as JPL provided Core Engineering Support

UK PubMed Central (United Kingdom)

The phosphatidylinositol pathway is implicated in the regulation of numerous cellular functions and responses to extracellular signals. An important branching point in the pathway is the phosphorylation...Full Text Available

UK PubMed Central (United Kingdom)

Six species having characteristics of plants with the C₄ dicarboxylic photosynthetic pathway, Echinochloa utilis L. Ohwi et Yabuno (Japanese millet), Cynodon dactylon...Full Text Available

UK PubMed Central (United Kingdom)

Background & Aimsβ-catenin signaling within the canonical Wnt pathway is essential for pancreas development. However, the pathway is normally down-regulated...Full Text Available

UK PubMed Central (United Kingdom)

In this study we compared the molecular signalling elicited by rexinoids, selective retinoid X receptor (RXR)-activators, in several organs (i.e. liver, kidney,...Full Text Available

UK PubMed Central (United Kingdom)

The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1...Full Text Available

UK PubMed Central (United Kingdom)

Chlorazole fast pink 2BL inhibited the classical complement pathway in rat serum both in vivo and in vitro. The in vitro potency of chlorazole fast pink against the alternative pathway could not be...Full Text Available

International Nuclear Information System (INIS)

... air pollution coprecipitation isotope production lead 203 proton beams

Energy Technology Data Exchange (ETDEWEB)

The passive continental margin in the northern South China Sea is a weakly active area. It has been found to be favorable for large gas field development and also to be profitable for gas hydrate. The active faults, diapir structure, slump deposits, faults break of slopes, gas chimneys and sandstone of submarine fan, control the concentration of gas hydrate. Gas chimneys are widely distributed in the northern South China Sea. They supply the pathway for migration of deeper gas to gas hydrate stability zones especially in the basin of tectonic inactive zone. This paper discussed the geological structures of gas hydrate occurrence in gas fields and presented a detailed analysis of gas chimneys within the northern slope of the South China Sea. The paper described the geological setting of the Qiongdongnan Basin and provided information on the data description and processing. Two multichannel seismic (MCS) reflection profiles were used for the study. In order to ...

International Nuclear Information System (INIS)

Nuclear analytical techniques were applied to determine the elemental compositions of suspended and bottom sediments, collected at different sites in Haiphong harbor area (North Viet nam). The study was aimed at: 1/Understanding the origin of the sediment filling up the access channel and causing large expenditures for dredging operations. 2/Determining the background concentrations of trace elements in sediment. This would allow to detect in the future any pollution caused by the discharge of industrial wastes in the water due to the growing industrialization of the area. 3/Identifying the elements, which can be served as activatable tracers in sediment transport studies. The results obtained for the concentrations of nearly 30 elements show rather similar elemental compositions, reflecting a common origin of the sediments taken from different locations in the harbour area. The results could not allow to identify the ...

Science.gov (United States)

Several examples of agonist-directed trafficking of receptor signalling at 5-HT2A and 5-HT2C receptors have been reported that involve independent downstream transduction pathways. We now report the functional selectivity of a series of chemically diverse agonists at human (h)5-HT2A, h5-HT2B and h5-HT2C-VSV by examining two related responses, the upstream activation of Gq/11 proteins in comparison with its associated cascade of calcium mobilisation. At the h5-HT2A receptor, d-lysergic acid diethylamide (LSD) and the antiparkinsonian agents lisuride, bromocriptine and pergolide exhibit a higher potency for Gq/11 activation than calcium release in contrast with all the other tested ligands such as 5-HT, mCPP and BW723C86, that show an opposite preference of signalling pathway. Comparable observations are made at h5-HT2B and h5-HT2C-VSV receptors, suggesting a similar mechanism of functional selectivity for the three serotonin receptors. ...

Science.gov (United States)

Rice is a very important food staple that feeds more than half the world's population. Two major Asian cultivated rice (Oryza sativa L.) subspecies, japonica and indica, show significant phenotypic variation in their stress responses. However, the molecular mechanisms underlying this phenotypic variation are still largely unknown. A common link among different stresses is that they produce an oxidative burst and result in an increase of reactive oxygen species (ROS). In this study, methyl viologen (MV) as a ROS agent was applied to investigate the rice oxidative stress response. We observed that 93-11 (indica) seedlings exhibited leaf senescence with severe lesions under MV treatment compared to Nipponbare (japonica). Whole-genome microarray experiments were conducted, and 1,062 probe sets were identified with gene expression level polymorphisms between the two rice cultivars in addition to differential expression under MV treatment, which were assigned as ...

International Nuclear Information System (INIS)

New surface photometry of all known elliptical galaxies in the Virgo cluster is combined with published data to derive composite profiles of brightness, ellipticity, position angle, isophote shape, and color over large radius ranges. These provide enough leverage to show that Sersic log I #propor to# r "1"/"n functions fit the brightness profiles I(r) of nearly all ellipticals remarkably well over large dynamic ranges. Therefore, we can confidently identify departures from these profiles that are diagnostic of galaxy formation. Two kinds of departures are seen at small radii. All 10 of our ellipticals with total absolute magnitudes M_V_T #<=# -21.66 have cuspy cores-"missing light"-at small radii. Cores are well known and naturally scoured by binary black holes (BHs) formed in dissipationless ("dry") mergers. All 17 ellipticals with -21.54 #<=# M_V_T #<=# -15.53 do not have cores. We find a new ...

Energy Technology Data Exchange (ETDEWEB)

A theoretical derivation of the intershell mass--core mass relation of Paczynski is attempted. Formulae developed by Sugimoto and Fujimoto are extended to less massive (m/sub c/< or approx. =1) cores.

International Nuclear Information System (INIS)

An overview is presented of the FFTF reactor and plant together with descriptions of core components, core internals, core system, primary and secondary control rod system, reactor instrumentation, reactor vessel and closure head, and supporting test programs.

International Nuclear Information System (INIS)

The accurate prediction of local hot spot during normal operation is important to ensure core thermal margin in a very high temperature gas-cooled reactor because of production of its high temperature output. The active cooling of the reactor core determining local hot spot is strongly affected by core bypass flows through the inter-column gaps between graphite blocks and the cross gaps between two stacked fuel blocks. The bypass gap sizes vary during core life cycle by the thermal expansion at the elevated temperature and the shrinkage/swelling by fast neutron irradiation. This study is to investigate the impacts of the variation of bypass gaps during core life cycle as well as core restraint mechanism on the amount of bypass flow and thus maximum fuel temperature. The core thermo fluid analysis is performed using the GAMMA+ code for the ...

CERN Document Server

We examine star clusters in the irregular, starburst galaxy NGC 1569 from HST images. In addition to the two known super star clusters, we identify 45 other clusters that are compact but resolved. Integrated UVI colors of the clusters span a large range, and suggest that ages range from 3 Myrs to 1 Gyr. However, most of the clusters were formed at the tail end of the recent starburst. Numerous clusters in addition to the know super star clusters are similar in luminosity to a small globular cluster. We examined the radial surface brightness of four of the clusters. Their half-light radii and core radii are in the range observed in present-day globular clusters. Therefore, conditions that produced the recent starburst have also been those necessary for producing compact, bright star clusters. We examine resolved stars in the outer parts of the two super star clusters. Cluster A is dominated by bright blue stars with a small population of red ...

Energy Technology Data Exchange (ETDEWEB)

Mechanistic models of aerosol decontamination by an overlying water pool during core debris/concrete interactions and spray removal of aerosols from a Mark I drywell atmosphere are developed. Eighteen uncertain features of the pool decontamination model and 19 uncertain features of the model for the rate coefficient of spray removal of aerosols are identified. Ranges for values of parameters that characterize these uncertain features of the models are established. Probability density functions for values within these ranges are assigned according to a set of rules. A Monte Carlo uncertainty analysis of the decontamination factor produced by water pools 30 and 50 cm deep and subcooled 0--70 K is performed. An uncertainty analysis for the rate constant of spray removal of aerosols is done for water fluxes of 0.25, 0.01, and 0.001 cm{sup 3} H{sub 2}O/cm{sup 2}-s and decontamination factors of 1.1, 2, 3.3, 10, 100, and 1000.

International Nuclear Information System (INIS)

A ground-breaking study was recently completed as part of the Seabrook Level 2 PRA update. This study updates the post-core damage phenomena to be consistent with the most recent information and includes accident management activities that should be modeled in the Level 2 PRA. Overall, the result is a Level 2 PRA that fully meets the requirements of the ASME PRA Standard with respect to modeling accident management in the LERF assessment and NRC requirements in Regulatory Guide 1.174 for considering late containment failures. This technical paper deals only with the incorporation of operator actions into the Level 2 PRA based on a comprehensive study of the Seabrook Station accident response procedures and guidance. The paper describes the process used to identify the key operator actions that can influence the Level 2 PRA results and the development of success criteria for these key operator actions. This addresses a key requirement of the ...

Energy Technology Data Exchange (ETDEWEB)

The reliability of the surface condenser is a key factor in plant performance level and maintenance cost optimization. This is especially the case for thermal nuclear plants where condenser raw wa-ter ingress can introduce contamination into the chemically-controlled, steam/water loop potentially causing damage to sensitive equipment. Two important parameters must be taken into account when attempting to optimize the quality and the reliability of condenser tubing. They include selecting the appropriate material according to the cooling water corrosion level present. A second and equally important parameter is the manufac-turing of the tubing product itself. This paper will identify methods to optimize manufacturing processes and improve tubing quality, according to VALTIMET's 30 years of condenser welded tubing production experience. Those methods complete the core manufacturing process (forming and welding), through improvement of ...

Energy Technology Data Exchange (ETDEWEB)

[alpha]-Melanocyte stimulating hormone ([alpha]-MSH), a hormone originally named for its ability to regulate pigmentation of melanocytes, is a 13-amino-acid post-translational product of the pro-opiomelanocortin (POMC) gene. [alpha]-MSH and the other products of POMC processing, which share the core heptapeptide amino acid sequence Met-Glu (Gly)-His-Phe-Arg-Trp-Gly (Asp), the adrenocorticotropic hormone (ACTH), [beta]-MSH, and [gamma]-MSH, are collectively referred to as melanocortins. While best known for their effects on the melanocyte (pigmentation) and adrenal cortical cells (steroidogenesis), melanocortins have been postulated to function in diverse activities, including enhancement of learning and memory, control of the cardiovascular system, analgesia, thermoregulation, immunomodulation, parturition, and neurotrophism. To identify the chromosomal band encoding the human melanocortin-1 receptor gene, 1 [mu]g of an EMBL clone coding region ...

Energy Technology Data Exchange (ETDEWEB)

Negative ion electrospray ionization (ESI) coupled with high field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) allows for the direct detection of acidic NSO compounds in petroleum. The technique requires no chromatographic separation, is able to distinguish 18 different compound classes (e.g., neutral nitrogen, carboxylic acids and oxygenates), and can identify {approx}14,000 distinct masses by ultra-high mass resolution and mass accuracy. We previously studied three crude oils from different geological origins [Organic Geochemistry 33 (2002b) 743-759]. Here, we expand our research by comparing two source-equivalent Smackover oils of different levels of thermal maturity. We observe clear differences in the distribution of NSO compound classes, types (number of rings plus double bonds within a class), and number of alkyl carbons. With increasing thermal stress, the relative amount of sulfur and oxygen containing compounds decreases, ...

Energy Technology Data Exchange (ETDEWEB)

The primary goal of this project is to increase the availability and ease of access to critical data on the Mesaverde and Dakota tight gas reservoirs of the San Juan Basin. Secondary goals include tuning well log interpretations through integration of core, water chemistry and production analysis data to help identify bypassed pay zones; increased knowledge of permeability ratios and how they affect well drainage and thus infill drilling plans; improved time-depth correlations through regional mapping of sonic logs; and improved understanding of the variability of formation waters within the basin through spatial analysis of water chemistry data. The project will collect, integrate, and analyze a variety of petrophysical and well data concerning the Mesaverde and Dakota reservoirs of the San Juan Basin, with particular emphasis on data available in the areas defined as tight gas areas for purpose of FERC. A relational, geo-referenced database ...

International Nuclear Information System (INIS)

This report discusses the safety approach of the Advanced Liquid Metal reactor program, sponsored by the US Department of Energy, which relies upon passive reactor responses to off-normal condition to limit power and temperature excursions to levels that allow safety margins. Gas expansion modules (GEM) have included in the design to provide negative reactivity to enhance these margins in the extremely unlikely event that pumping power is lost and the highly reliable scram system fails to operate. The feasibility and beneficial features of these devices were first demonstrated in the core of the Fast Flux Test Facility (FFTF) in 1986. Preapplication safety evaluations by the US Nuclear Regulatory Commission have identified areas that must be addressed if these devices are to be relied on. One of these areas is the response of the reactor when it is critical and the pumps are turned on, resulting in positive reactivity being added to the ...

International Nuclear Information System (INIS)

The FFTF is a 400-MWt sodium-cooled fast neutron flux test reactor located on the US government-owned Hanford Site in southeastern Washington state. The reactor is operated for the US Department of Energy by the Westinghouse Hanford Company. Since FFTF started routine operation in 1982, the commercially fabricated driver fuel has performed flawlessly to well beyond the design goal peak burnup of 80 MWd/kgM. The core average discharge exposure is now some 60% beyond the original design expectations and attests to the ruggedness and reliability of the mixed oxide fuel system. In Cycle 9 sixteen long-life assemblies were installed to begin the irradiation of mixed oxides in the advanced low-swelling alloy HT-9 as the Core Demonstration Experiment (CDE). Operation of the plant from initial startup testing to ten cycles of operation has confirmed that the nuclear characteristics are well within the design predictions, and all parameters have ...

Energy Technology Data Exchange (ETDEWEB)

This annual report describes the progress during the fourth year of the project on {open_quotes}Integrated Approach Towards the Application of Horizontal Wells to Improve Waterflooding Performance{close_quotes}. The project involves using an integrated approach to characterize the reservoir followed by proposing an appropriate reservoir management strategy to improve the field performance. In the first stage of the project, the type of data we integrated include cross borehole seismic surveys, geological interpretation based on the logs and the cores, and the engineering information. In contrast, during the second stage of the project, we intend to use only conventional data to construct the reservoir description. This report covers the results of the implementation from the first stage of the project. It also discusses the work accomplished so far for the second stage of the project. The production from the Self Unit (location of Stage 1) has sustained an increase ...

Energy Technology Data Exchange (ETDEWEB)

The objective of this work is to determine the ability of indigenous bacteria from a Venezuelan oil field to grow under reservoir conditions inside a porous media, and to produce metabolites capable of recovering residual crude oil. For this purpose, samples of formation waters from a central-eastern Venezuelan oil reservoir were enriched with different carbon sources and a mineral basal media. Formation water was used as a source of trace metals. The enrichments obtained were incubated at reservoir temperature (71{degrees}C), reservoir pressure (1,200 psi), and under anaerobic conditions for both outside and inside porous media (Berea core). Growth and metabolic activity was followed outside porous media by measuring absorbance at 660 nm, increases in pressure, and decreases in pH. Inside porous media bacterial activity was determined by visual examination of the produced waters (gas bubbles and bacterial cells). All the carbohydrates tested outside porous media ...

Energy Technology Data Exchange (ETDEWEB)

In nuclear reactor safety research, the question of the possible consequences of delayed core reflood during severe accidents or anticipated transient without scram transients in boiling water reactors (BWRs) has been raised. One can envisage a very low probability accident scenario leading to core uncovery and core heat-up, followed by control blade melting and subsequential delayed reflooding of the core with unborated water before its degradation. Reflooding of the hot core causes significant increases in the peak heating, melting, and hydrogen production rates, thus increasing the probability of core degradation. However, as has been established, debris beds formed from shattered fuel rods and quenched fuel melt will be undermoderated. The reflood process of a voided, intact core was examined using the TRAC/BFI CODE.

Science.gov (United States)

... Accession Number : ADD331250. Title : Characterizing Differential Air-Core Eddy Current Probes. Corporate Author : Personal ...

Energy Technology Data Exchange (ETDEWEB)

Gas-insulated systems employing SF/sub 6/ are utilized in a variety of applications in power delivery systems. Because electric arcs, sparks or corona can decompose SF/sub 6/ into byproducts having chemical properties different from SF/sub 6/, environmental concerns arise regarding inadvertent human exposures to electrically-decomposed SF/sub 6/. Biological assays in our laboratory using mammalian cell culture systems have revealed that spark-decomposed SF/sub 6/ produces cell death, and the extent of cell killing increases with increasing spark energy. Chemical analysis of spark-decomposed SF/sub 6/ has identified the major decomposition pathways and byproducts, but biological testing of individual or byproduct mixtures has indicated that these major decomposition products do not contribute, in a significant fashion, to the cell lethality seen in our assays. Further experiments have suggested that S/sub 2/F/sub 10/ may be produced under our ...

Energy Technology Data Exchange (ETDEWEB)

As semiconductor device density and wafer area continue to increase, the volume of in-line and off-line data required to diagnose yield-limiting conditions is growing exponentially. To manage this data in the future, analysis tools will be required that can automatically reduce this data to useful information, e.g., by assisting the engineer in rapid root-cause diagnosis of defect generating mechanisms. In this paper, the authors describe a technology known as Spatial Signature Analysis (SSA) and its application to both optically-detected defect data as well as electrical test (e-test) bin data. The results of a validation study are summarized that demonstrate the effectiveness of the SSA approach on optical defect wafermaps through field-testing at three semiconductor manufacturing sites on ASIC, DRAM and SRAM products. This method has been extended to analyze and interpret electrical test data and to provide a pathway for correlation of this data with in-line ...

International Nuclear Information System (INIS)

Thermoluminescence (TL) and Electron Paramagnetic Resonance (EPR) dosimetry were used to measure dose effects in borosilicate glass with time, from 10 minutes to #approx#60 days following exposure to a dose of up to 10,000 Rad. TL and EPR results were consistent and performed similarly, with both techniques capable of achieving an estimated limit of detection of between 50-100 Rad. Three peaks were identified in the TL glow curve at roughly 110 C, 205 C, and 225 C. The intensity of the 205 C peak was the dominant peak over the time period of this study. The stability of all of the peaks with time since irradiation increased with their corresponding temperature and little or no variation was observed in the glow curve response to a specified total dose attained at different dose rates. The intensity of the 205 C peak decreased logarithmically with time regardless of total dose. Based upon a conservative limit of detection of 330 Rad, a 10,000 Rad dose would still be ...

Energy Technology Data Exchange (ETDEWEB)

In June 1997, the US Navy plans to close its Naval Air Facility on Sand Island and transfer the atoll to the US Fish and Wildlife Service for use as a National Wildlife Refuge. Midway provides breeding and feeding habitat for migratory seabirds, terrestrial and marine mammals, sea turtles and other reptiles, and a variety of reef fishes and invertebrates. As part of the base closure and transfer process, 36 sites of potential environmental concern were identified on Sand and Eastern islands. These sites include landfills and uncontrolled disposal areas, hazardous materials storage areas, abandoned transformers, sewer outfalls, and other potential hazardous waste sites. Potential contaminants include pesticides, PAHs, PCBs, and heavy metals. A screening ecological risk assessment was performed at each site with a goal of determining whether contaminants could pose any current or future risks to protected migratory bird or marine mammal wildlife species. Specific ...

DEFF Research Database (Denmark)

Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.

UK PubMed Central (United Kingdom)

SUMMARYTestosterone and estrogen are essential for male behaviors in vertebrates. How these two signaling pathways interact to control masculinization of the brain and behavior...Full Text Available

UK PubMed Central (United Kingdom)

Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic events commandeer many signaling pathways that cooperate to endow aspiring...Full Text Available

UK PubMed Central (United Kingdom)

This manuscript discusses the physiology of the autonomic nervous system (ANS). The following topics are presented: regulation of activity; efferent pathways; sympathetic and parasympathetic divisions;...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Pathway analyses are regarded by National Plant Protection Organizations as a very efficient way to address the risks posed by invasive alien species. Data on import of aquatic plants was obtained from 10 EPPO countries (Austria, Czech Republic, Estonia, France, Germany, Hungary, the Netherlands, Latvia, Switzerland and Turkey) and aggregated in order to consider whether invasive or potentially invasive alien plants could be introduced in the EPPO region through this pathway. This study highlights that this pathway mainly consists of the import of tropical plants for use in aquaria, and which do not represent a risk due to their climatic requirements. However, a few species require thorough attention owing to the threats they cause. Of the 247 species recorded as imported, only 10 are curr...

Science.gov (United States)

The Liver Carcinogenesis Section uses the modern technologies of molecular biology, cell biology, protein chemistry and genetics to investigate the biochemical and genetic pathways involved in human liver cancer.

Energy Technology Data Exchange (ETDEWEB)

The ingestion pathway consequences following an accidental tritium release from the Savannah River Site Tritium Facilities are evaluated.

Science.gov (United States)

Turbine Afterword The SHARP cannon. Hydrogen is compressed in the tube on top, the gun barrel is on bottom. When Jules Verne wrote in 1865 "From Earth to the Moon" he envisioned...

UK PubMed Central (United Kingdom)

The ability of a number of mycobacteria and some of their components to activate complement was examined. Mycobacterium bovis BCG (Glaxo strain), Mycobacterium leprae, Mycobacterium lepraemurium, and...Full Text Available

Science.gov (United States)

Twenty-two landrace-derived inbred lines from the Spanish Barley Core Collection (SBCC) were found to display high levels of resistance to a panel of 27 isolates of the fungus Blumeria graminis that exhibit a wide variety of virulences. Among these lines, SBCC145 showed high overall resistance and a distinctive spectrum of resistance compared with the other lines. Against this background, the main goal of the present work was to investigate the genetic basis underlying such resistance using a doubled haploid population derived from a cross between SBCC145 and the elite spring cultivar Beatrix. The population was genotyped with the 1,536-SNP Illumina GoldenGate Oligonucleotide Pool Assay (Barley OPA-1 or BOPA1 for short), whereas phenotypic analysis was performed using two B. graminis isolates. A major quantitative trait locus (QTL) for resistance to both isolates was identified on the long arm of chromosome 6H (6HL) and accounted for ca. 60% of ...

International Nuclear Information System (INIS)

Korea Atomic Energy Research Institute, using the ANS low power and shutdown (LPSD) probabilistic risk assessment (PRA) Standard, evaluated the LPSD PSA model of the KSNP, Yonggwang Units 5 and 6, and identified the items to be improved. The evaluation results of human reliability analysis (HRA) of the post-accident human errors in the LPSD PSA model for the KSNP showed that 10 items among 19 items of supporting requirements for those in the ANS PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for post-accident human errors in the LPSD PSA model for the KSNP. Following tasks are the improvements in the HRA of post-accident human errors of the LPSD PSA model for the KSNP compared with the previous one: Interviews with operators in the interpretation of the procedure, modeling of operator actions, and the quantification results of human errors, site visit. Applications of limiting value to the combined ...

KoreaScience (Korea)

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International Nuclear Information System (INIS)

Dynamical models are presented that start with interstellar gas in an initial diffuse state and consider their gravitational collapse and the formation of dense cores. Frozen-in tangled magnetic fields are included to mimic forces that might oppose gravitational contraction and whose effectiveness may increase with increasing core densities. Results suggest the possibility that dense cloud cores may be dynamically evolving ephemeral objects, such that their lifespan at a given core density decreases as that density increases. 66 refs.

Energy Technology Data Exchange (ETDEWEB)

ExternE is a pan{sub E}uropean project aimed at identifying and quantifying external effects from different energy production technologies around Europe. The Swedish implementation carried out case studies on a biomass plant, a coal plant and a hydro power plant. The conventional approach within the ExternE project is to estimate impacts for each priority pathway associated with the fuel cycle, and then economic methods to obtain estimates for the economic damage of each particular impact pathway. However, in the case of hydro power, it is generally not possible to estimate the most important impacts quantitatively. Therefore, a contingent valuation (CV) study was initiated. In a typical CV-study, a selection of individuals are asked to state their willingness to pay for a certain environmental improvement or to avoid an environmental damage. Welfare economic theory suggests that the well-being effects on people from a ...

International Nuclear Information System (INIS)

A comparative core design study is performed on Pb-Bi cooled reactors with forced and natural convection (FC and NC) cooling. Major interests of the study are core performance and core safety features. The designed core concepts with nitride fuel achieve reasonable breeding capability. The results of unprotected event analyses such as UTOP and ULOF show that both of concepts have possible features to withstand unprotected events due to negative reactivity feedback by Doppler effect, control rod drive line expansion, etc. These results lead to a conclusion that both of concepts have possible capability as one of future promising core concepts. A FC cooling core concept has more advantage if fuel recycle viewpoint is emphasized. (author)

UK PubMed Central (United Kingdom)

The rates of synthesis of a class of both secreted and intracellular degradative enzymes in Bacillus subtilis are controlled by a signal transduction pathway defined by at least four regulatory genes:...Full Text Available

UK PubMed Central (United Kingdom)

Immune challenge induces behavioral changes including reduced ingestion of palatable food. Multiple pathways likely contribute to this effect, including viscerosensory pathways controlling hypothalamic...Full Text Available

Science.gov (United States)

Six species having characteristics of plants with the C(4) dicarboxylic photosynthetic pathway, Echinochloa utilis L. Ohwi et Yabuno (Japanese millet), Cynodon dactylon L. (Bermuda grass), Kyllinga brevifolia Rottb., Amaranthus tricolor L. cv. Early splendour, Kochia childsii Hort., and Portulaca grandiflora Hook (rose moss), responded decisively to 0.1 milliequivalent per liter NaCl supplied to their culture solutions initially containing less than 0.08 microequivalent per liter Na. Chlorosis and necrosis occurred in leaves of plants not receiving sodium. Portulaca failed to set flower in the sodium-deficient cultures. Under similar conditions Poa pratensis L. (Kentucky blue grass) having characteristics of the C(3) photosynthetic pathway made normal growth and did not respond to the addition of sodium. It is concluded from these results and previously reported work that sodium is generally essential for species having the C(4) ...

Energy Technology Data Exchange (ETDEWEB)

CuAg core-shell nanoparticles are synthesized by ultra-high vacuum thermal evaporation. We show on this system how the Energy-Filtered Transmission Electron Microscopy (EFTEM) technique allows one to improve the characterization by precisely pointing out the formation of core-shell arrangements in bimetallic nanoparticle assemblies. A criterion to measure the shell thickness from EFTEM images on unique core-shell nanoparticles is defined, that can be used for core-shell nanoparticles of any sizes, with shell thicknesses over 1 nm. It is based on the intensity variation along a line drawn across a core-shell nanoparticle on a EFTEM image. This criterion has been validated by a close comparison of the shell thickness measurements performed in this work and the ones obtained by acoustic micro-Raman spectroscopy. Using this criterion, we report a strong correlation between the size of ...

International Nuclear Information System (INIS)

Liquid Zone Control (LZC) System is a 'first-of-its-kind' reactivity control device, designed and implemented at TAPP-3 and 4. The system provides zonal and bulk power control. The system consists of fourteen Zone Control Compartments (ZCCs) containing demineralised light water as neutron absorber. Reactivity control is achieved by varying the level of water in the compartments bi-directionally. Six in-core zircaloy assemblies, housing the fourteen ZCCs and an elaborate process system constitute the LZC system. Measurement of water levels in the ZCCs is done using helium bubbler method. Reliability of ZCC water level measurement is of paramount importance. Commissioning and operating the new system trouble free was a challenge, considering the complex nature of the system. While commissioning the system, level measurement of one of the ZCCs (ZCC - 1) was found erratic and inconsistent. Methodologies were developed to identify the problem and ...

International Nuclear Information System (INIS)

In order to assess various core parameters a reference equilibrium core with Low Enriched Uranium (LEU) fuel for Pakistan Research Reactor (PARR-1) was assembled. Due to increased volume of reference core, the average neutron flux reduced as compared to the first higher power operation. To get a higher neutron flux an irradiation facility was created in centre of the reference equilibrium core where the advantage of the neutron flux peaking was taken. Various low power experiments were performed in order to evaluate control rods worth and neutron flux mapping inside the core. The neutron flux inside the central irradiation facility almost doubled. With this arrangement reactor operation time was cut down from 72 hours to 48 hours for the production of the required specific radioactivity. (author)

International Nuclear Information System (INIS)

One-dimensional core-shell polymer nanowires offer many advantages and great potential for many different applications. In this paper we introduce a highly versatile two-step template wetting process to fabricate two-component core-shell polymer nanowires with controllable shell thickness. PLLA and PMMA were chosen as model polymers to demonstrate the feasibility of this process. Solution wetting with different concentrations of polymer solutions was used to fabricate the shell layer and melt wetting was used to fill the shell with the core polymer. The shell thickness was analyzed as a function of the polymer solution concentration and viscosity, and the core-shell morphology was observed with TEM. This paper demonstrates the feasibility of fabricating polymer core-shell nanostructures using our two-step template wetting process and opens the arena for optimization and future ...

Science.gov (United States)

A critical factor in the advancement of biomedical research is the ease with which data can be integrated, redistributed and analyzed both within and across domains. This paper summarizes the Biomedical Information Core Infrastructure built by National Cancer Institute Center for Bioinformatics in America (NCICB). The main product from the Core Infrastructure is caCORE--cancer Common Ontologic Reference Environment, which is the infrastructure backbone supporting data management and application development at NCICB. The paper explains the structure and function of caCORE: (1) Enterprise Vocabulary Services (EVS). They provide controlled vocabulary, dictionary and thesaurus services, and EVS produces the NCI Thesaurus and the NCI Metathesaurus; (2) The Cancer Data Standards Repository (caDSR). It provides a metadata registry for common data elements. (3) Cancer Bioinformatics Infrastructure Objects ...

KoreaScience (Korea)

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Science.gov (United States)

Within the framework of the cluster approach and the semiempirical SCF MO LCAO method in the CNDO/BW valence approximation, possible pathways have been compared for the dehydroxylation of aluminosilicate systems. It has been shown that dehydroxylation as a result of splitting of a water molecule from an acidic bridge hydroxyl group and a more basic terminal group Al-OH is the most energyfavorable. Apparently, such a dehydroxylation pathway is primarily characteristic for amorphous aluminosilicates. Typical of crystalline aluminosilicates at moderate heat-treating temperature is dehydroxylation through splitting of a water molecule from an acidic bridge hydroxyl group and a neutral Si-OH group; at higher temperatures, there is a possible pathway of dehydroxylation of highsilica zeolites as a result of condensation of two acidic surface hydroxyls.

Energy Technology Data Exchange (ETDEWEB)

The cyclic voltammetry indicated that the oxygen reduction reaction (ORR) proceeded by the four-electron pathway mechanism on larger Ag particles (174 nm), and that the ORR proceeded by the four-electron pathway and the two-electron pathway mechanisms on finer Ag particles (4.1 nm), simultaneously. The kinetics towards ORR was measured at a rotating disk electrode (RDE) with Ag/C electrode. The number of exchanged electrons for the ORR was found to be close to four on larger Ag particles (174 nm) and close to three on finer Ag particles (4.1 nm). The zinc-air battery with Ag/C catalysts (25.9 nm) was fabricated and examined. (author)

International Nuclear Information System (INIS)

For a number of starless cores, self-absorbed molecular line and column density observations have implied the presence of large-amplitude oscillations. We examine the consequences of these oscillations on the evolution of the cores and the interpretation of their observations. We find that the pulsation energy helps support the cores and that the dissipation of this energy can lead toward instability and star formation. In this picture, the core lifetimes are limited by the pulsation-decay timescales, dominated by non-linear mode-mode coupling, and on the order of #approx =# few x 10"5-10"6 yr. Notably, this is similar to what is required to explain the relatively low rate of conversion of cores into stars. For cores with large-amplitude oscillations, dust continuum observations may appear asymmetric or irregular. As a consequence, some of the ...

Energy Technology Data Exchange (ETDEWEB)

Several low-mass models with an inhomogeneous radiative core and a convective envelope are investigated, the entire core or its upper portion being treated as a zone of neutral stability. Mixing by convective overshoot will then give rise to unstable structure.

International Nuclear Information System (INIS)

The core of Prismatic Modular Reactor (PMR) consists of assemblies of hexagonal graphite fuel and reflector elements. The core bypass flow of Very High Temperature Reactor (VHTR) is defined as the core flow that does not pass through the coolant channels but passes through the bypass gap between fuel elements. The increase in bypass flow makes the decrease in effective coolant flow. Since the core bypass flow has a negative impact on safety and efficiency of VHTR, core bypass phenomena have to be investigated to improve the core thermal margin of VHTR. For this purpose, the international project, I-NERI project, has been carried out since 2008. I-NERI project is collaborative project that KAERI and SNU of Korea side and INL, ANL and TAMU of U.S side are involved. In order to evaluate the core bypass flow, the multicolumn and multi-layer ...

International Nuclear Information System (INIS)

Core-collapse supernovae are among Nature's most energetic events. They mark the end of massive star evolution and pollute the interstellar medium with the life-enabling ashes of thermonuclear burning. Despite their importance for the evolution of galaxies and life in the universe, the details of the core-collapse supernova explosion mechanism remain in the dark and pose a daunting computational challenge. We outline the multi-dimensional, multi-scale, and multi-physics nature of the core-collapse supernova problem and discuss computational strategies and requirements for its solution. Specifically, we highlight the axisymmetric (2D) radiation-MHD code VULCAN/2D and present results obtained from the first full-2D angle-dependent neutrino radiation-hydrodynamics simulations of the post-core-bounce supernova evolution. We then go on to discuss the new code Zelmani which is based on the open-source HPC ...

UK PubMed Central (United Kingdom)

Nitrogenase activity was measured by the C₂H₂ reduction method in large soil cores (29 cm in diameter by 20 cm in depth) of maize (Zea mays) and sorghum (Sorghum...Full Text Available

International Nuclear Information System (INIS)

... Development Center, National Tsing-Hua University, Hsinchu, TW (China)

Science.gov (United States)

Not Available

Science.gov (United States)

... The moisture content-dimension relationship of two laminate components, phenolic core and melamine overlay, are compared. (Author, modified). ...

KoreaScience (Korea)

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Science.gov (United States)

... HARDENED CUP AND CARBURIZED AND HARDENED CORES HAVE BEEN PROFILED USING 2 TYPES OF EDDY CURRENT PROBES. ...

International Nuclear Information System (INIS)

The Fast Flux Test Facility near Richland, Washington, utilizes computer control for reactor refueling and other related core component handling and processing tasks. The computer controlled tasks described in this paper include core component transfers within the reactor vessel, core component transfers into and out of the reactor vessel, remote duct measurements of irradiated core components, remote duct cutting, and finally, transferring irradiated components out of the reactor containment building for off-site shipments or to long term storage. 3 refs., 16 figs.

Energy Technology Data Exchange (ETDEWEB)

The WBURN (2-D, 2-group, coarse mesh) code is developed to analyze the equilibrium core characteristics of CANDU-PHWR. The equilibrium characteristics of Wolsung reactor computed by using WBURN are compared with the values given in the Wolsung FSR. The changes of equilibrium core characteristics caused by the variation of design parameters for operating conditions are also investigated. The numerical results indicate that the average discharge irradiation in the Wolsung reactor can be increased up to about 5%.

Energy Technology Data Exchange (ETDEWEB)

Calculations have been performed to study the dependence on model parameters of convectively heating the region interior to the core convection zone for core helium flash models. We find that interior heating always occurs on a time scale significantly shorter than the evolutionary time scale even at the peak of the flash.

UK PubMed Central (United Kingdom)

A refined map for the linear arrangement of histones along DNA in nucleosomal core particles has been determined by DNA-protein crosslinking. On one strand of 145-bp core DNA, histones are aligned in...Full Text Available

International Nuclear Information System (INIS)

The in-core reload design procedure, computer codes, design contents and comparison between expected design values and measured values for Daya Bay Nuclear Power Station are presented. The in-core reload design for Daya Bay Nuclear Power Station performed by Nuclear Power Institute of China satisfies the requirements of safety and economy. The expected design values are fit well with measured values

Energy Technology Data Exchange (ETDEWEB)

This report describes the basis, results, and related risk implications of an analysis performed by an ad hoc working group of the U.S. Nuclear Regulatory Commission (NRC) to assess the containment bypass potential attributable to steam generator tube rupture (SGTR) induced by severe accident conditions. The SGTR Severe Accident Working Group, comprised of staff members from the NRC`s Offices of Nuclear Reactor Regulation (NRR) and Nuclear Regulatory Research (RES), undertook the analysis beginning in December 1995 to support a proposed steam generator integrity rule. The work drew upon previous risk and thermal-hydraulic analyses of core damage sequences, with a focus on the Surry plant as a representative example. This analysis yielded new results, however, derived by predicting thermal-hydraulic conditions of selected severe accident scenarios using the SCDAP/RELAP5 computer code, flawed tube failure modeling, and tube failure probability estimates. These ...

Energy Technology Data Exchange (ETDEWEB)

The Korean Next Generation Reactor (KNGR) adopts 4-train Direct Vessel Injection (DVI) configuration and injects the safety injection water directly into the downcomer through the 8.5'' DVI nozzle. Thus, the thermal hydraulic phenomena such as ECCS mixing and bypass are expected to be different from those observed in the cold leg injection. In order to investigate the realistic injection phenomena and modify the analysis code developed in the basis of cold leg injection, thermal hydraulic test with the performance evaluation is required. Preliminarily, the sequence of events and major thermal hydraulic phenomena during the small break LOCA for KNGR are identified from the analysis results calculated by the CEFLASH-4AS/REM. It is shown from the analysis results that the major transient behaviors including the core mixture level are largely affected by the downcomer modeling. Therefore, to investigate the proper thermal ...

Science.gov (United States)

Within the Williston basin, thickness variations of the Prairie Formation are common and are interpreted to originate by two processes: differential accumulation of salt during deposition and differential removal of salt by dissolution. Unambiguous evidence for each process is rare because the Prairie/Winnipegosis interval is seldom cored within the US portion of the basin. Therefore, indirect methods, using well logs, provide the principal method for identifying characteristics of the two processes. The results of this study indicate that the two processes can be distinguished using correlations within the Prairie Formation. Several regionally correlative brining-upward and probably shoaling-upward sequences occur within the Prairie Formation. Near the basin center, the lowermost sequence is transitional with the underlying Winnipegosis Formation. This transition is characterized by thinly laminated basal carbonates that become increasingly ...

Energy Technology Data Exchange (ETDEWEB)

The large aggregating proteoglycan aggrecan is a major structural component of the extracellular matrix of articular cartilage. Recent cDNA cloning of the human aggrecan gene (AGC1) reveals a core protein of at least 2316 amino acids characterized by several distinct structural domains. Two globular domains, termed G1 and G2, are present at the amino terminus of the molecule and a third, termed G3, is present at the carboxy terminus. The G1 domain is homologous in structure to the cartilage link protein and accounts for the aggregating potential of aggrecan through its ability to interact with hyaluronic acid. The aggrecan gene is known to consist of 15 exons, with each exon encoding a distinct functional region of the mature protein. However, while the link protein gene is known to reside on chromosome 5 in the human, the location of the aggrecan gene is currently undetermined in any species. The probe (pAGG2) for the aggrecan gene was mapped on chromosome band ...

International Nuclear Information System (INIS)

Based on the occurrence of a number of plant incidents during low power and shutdown operating conditions, the Nuclear Regulatory Commission (NRC) has initiated several programs to better quantify risk during these periods. One specific issue of interest is the loss of residual heat removal (RHR) under reduced coolant inventory conditions. This issue is also of interest in the Federal Republic of Germany and an experiment was performed in the integral PKL-3 experimental facility at Siemens-KWU to supply applicable data. Recently, an effort has been undertaken at the Idaho National Engineering Laboratory (INEL) to identify and analyze the important thermal-hydraulic phenomena in pressurized water reactors following loss of vital AC power and consequent loss of the RHR system during reduced inventory operation. The thermal-hydraulic response of a nuclear steam supply system (NSSS) with a closed reactor coolant system (RCS) to loss of residual heat removal cooling ...

UK PubMed Central (United Kingdom)

The central nervous system regulates peripheral immune responses via the vagus nerve, the primary neural component of the cholinergic anti-inflammatory pathway. Electrical stimulation of the...Full Text Available

UK PubMed Central (United Kingdom)

The lesion bypass pathway, which is regulated by monoubiquitination of proliferating cell nuclear antigen (PCNA), is essential for resolving replication stalling due to DNA lesions. This process is...Full Text Available

UK PubMed Central (United Kingdom)

Purpose of ReviewThe vertebrate cap’n’collar family transcription factor Nrf2 and its invertebrate homologs SKN-1 (in worms) and CncC (in flies) function...Full Text Available

UK PubMed Central (United Kingdom)

p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array...Full Text Available

UK PubMed Central (United Kingdom)

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover,...Full Text Available

UK PubMed Central (United Kingdom)

The canonical Wnt/β-catenin pathway plays a pivotal role in regulating embryogenesis and tumorigenesis by promoting cell proliferation. BAMBI (BMP and activin membrane-bound inhibitor) has...Full Text Available

UK PubMed Central (United Kingdom)

The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53...Full Text Available

UK PubMed Central (United Kingdom)

Dal82p binds to the UIS_ALL sites of allophanate-induced genes of the allantoin-degradative pathway and functions synergistically with the GATA family Gln3p and Gat1p transcriptional...Full Text Available

UK PubMed Central (United Kingdom)

Cysticercosis is an infection with larval cysts of the cestode Taenia solium. Through pathways that are incompletely understood, dying parasites initiate a granulomatous reaction that,...Full Text Available

UK PubMed Central (United Kingdom)

Photosynthetic (Ps) electron transport pathways often contain multiple electron carriers with overlapping functions. Here we focus on two c-type cytochromes (cyt) in facultative phototrophic...Full Text Available

UK PubMed Central (United Kingdom)

The prevalence of obesity among children, adolescents and adults has been dramatically increasing worldwide during the last several decades. The obesity epidemic has been recognized as one of...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYSmall bowel epithelium is at the frontline of intestinal barrier function. Restitution is considered to be the major determinant of epithelial repair as function recovers...Full Text Available

UK PubMed Central (United Kingdom)

Previous studies in several different trigeminal nerve injury/inflammation models indicated that the hyperexcitability of primary afferent neurons contributes to the pain pathway underlying mechanical...Full Text Available

Science.gov (United States)

... Weiss, S., D. Kobiler, H. Levy, H. Marcus, A. Pass, N. Rothschild, and Z ... of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits ...

UK PubMed Central (United Kingdom)

BackgroundIn Saccharomyces cerevisiae galactose is initially metabolized through the Leloir pathway after which glucose 6-phosphate enters glycolysis. Galactose...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVE—Identification of arterial genes and pathways altered in obesity and diabetes.RESEARCH DESIGN AND METHODS—Aortic gene expression profiles of...Full Text Available

UK PubMed Central (United Kingdom)

Microorganisms in the environment can often adapt to use xenobiotic chemicals as novel growth and energy substrates. Specialized enzyme systems and metabolic pathways for the degradation of man-made...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundIsopentenyl diphosphate (IPP), a common biosynthetic precursor to the labdane diterpene forskolin, has been biosynthesised via a non-mevalonate pathway. Geranylgeranyl...Full Text Available

UK PubMed Central (United Kingdom)

Melanoma is one of the most aggressive cancers, and its incidence is increasing. These tumors derive from the melanocyte lineage and remain incurable after metastasis. Here we report that SONIC HEDGEHOG...Full Text Available

UK PubMed Central (United Kingdom)

Hematopoietic stem and progenitor cell (HSPC) expansion is regulated by intrinsic signaling pathways activated by cytokines. The intracellular kinase JAK2 plays an essential role in cytokine signaling,...Full Text Available

UK PubMed Central (United Kingdom)

Dysregulation of the alternative pathway of complement activation, caused by mutations or polymorphisms in the genes encoding factor H, membrane co-factor protein, factor I or factor B, is associated...Full Text Available

Science.gov (United States)

Summary.? It is widely believed that hepatocellular cancer (HCC), especially HBV associated HCC, is highly resistant to chemotherapy. To investigate the molecular influence of HBx protein on multidrug resistance (MDR) in HCC and the potential role of the NF-?B pathway in this process. We established HBx-expressing cells by liposome-mediated transfection of the HBx into the HepG2 cell line. We found that HBx expression in HCC cells induces drug resistance against multiple drugs, a significantly lower apoptosis ratio in HepG2-HBx and HepG2.2.15 cells, compared with HepG2 and HepG2-3.1 cells (P?HCC cells were downregulated by IMD-0354 treatment, which is the NF-?B pathway inhibitor. Taken together, these results suggest that HBx protein might be one of the causes for the occurrence of MDR in HCC, and the NF-?B pathway might be involved in this change. PMID:21914061

UK PubMed Central (United Kingdom)

Salicylic acid (SA) is an important component of systemic-acquired resistance in plants. It is synthesized from benzoic acid (BA) as part of the phenylpropanoid pathway. Benzaldehyde (BD), a potential...Full Text Available

UK PubMed Central (United Kingdom)

The intramembrane aspartyl protease γ-secretase plays a fundamental role in several signaling pathways involved in cellular differentiation and has been linked with a variety of human diseases,...Full Text Available

UK PubMed Central (United Kingdom)

Auxin modulates diverse plant developmental pathways through direct transcriptional regulation and cooperative signaling with other plant hormones. Genetic and biochemical approaches have clarified...Full Text Available

UK PubMed Central (United Kingdom)

The supramammillary nucleus (SuM) provides substantial projections to the hippocampal formation. This hypothalamic structure is involved in the regulation of hippocampal theta rhythm and therefore...Full Text Available

UK PubMed Central (United Kingdom)

Purpose of reviewSevere congenital neutropenia (SCN) is a primary immunodeficiency in which lack of neutrophils causes inadequate innate immune host response to bacterial...Full Text Available

UK PubMed Central (United Kingdom)

All eukaryotes require mitochondria for survival and growth. The origin of mitochondria can be traced down to a single endosymbiotic event between two probably prokaryotic organisms. Subsequent evolution...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNeurofibromatosis type 1 (NF1) is a common monogenic tumor-predisposition disorder that arises secondary to mutations in the tumor suppressor gene NF1....Full Text Available

UK PubMed Central (United Kingdom)

Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma,...Full Text Available

UK PubMed Central (United Kingdom)

The p21-activated kinases (PAKs), immediate downstream effectors of the small G-proteins of the Rac/cdc42 family, are critical mediators of signaling pathways regulating cellular behaviors and...Full Text Available

UK PubMed Central (United Kingdom)

It has previously been established that muscles become active in response to deviations from a threshold (referent) position of the body or its segments, and that intentional motor actions result from...Full Text Available

UK PubMed Central (United Kingdom)

Carbohydrate/citrate cometabolism in Lactococcus lactis results in the formation of the flavor compound acetoin. Resting cells of strain IL1403(pFL3) rapidly consumed citrate while...Full Text Available

UK PubMed Central (United Kingdom)

Store-operated Ca²⁺ entry (SOCE) is a ubiquitous Ca²⁺ influx pathway involved in control of multiple cellular and physiological processes including cell proliferation. Recent evidence...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundAs the first pathway-specific enzyme in carotenoid biosynthesis, phytoene synthase (PSY) is a prime regulatory target. This includes a number of biotechnological approaches...Full Text Available

UK PubMed Central (United Kingdom)

In most insect species, juvenile hormones regulate critical physiological processes such as metamorphosis and reproduction. In insects, these sesquiterpenoids are synthesized by retrocerebral endocrine...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNetwork visualization would serve as a useful first step for analysis. However, current graph layout algorithms for biological pathways are insensitive to biologically...Full Text Available

UK PubMed Central (United Kingdom)

Muscarinic cholinergic receptors modulate dopaminergic function in brain pathways thought to mediate cocaine's abuse-related effects. Here, we sought to confirm and ...Full Text Available

UK PubMed Central (United Kingdom)

We used tryptophan auxotrophs of the dicot Arabidopsis thaliana (wall cress) to determine whether tryptophan has the capacity to serve as a precursor to the auxin, indole-3-acetic acid (IAA). Quantitative...Full Text Available

UK PubMed Central (United Kingdom)

The chlorophyll fluorescence characteristics of mesophyll and bundle-sheath thylakoids from plant species with the C4 dicarboxylic acid pathway of photosynthesis were investigated using flow cytometry....Full Text Available

UK PubMed Central (United Kingdom)

Atherosclerosis is an inflammatory process leading to enhanced cellular proliferation, apoptosis, and vasa vasorum (VV) neovascularization. While both diabetes mellitus (DM) and hypercholesterolemia...Full Text Available

UK PubMed Central (United Kingdom)

Twenty-four patients with infective endocarditis (IE) are described, fourteen with Staph. aureus and ten with other organisms. Despite the acute nature of the infection, ten of the fourteen with Staph....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe pH is an important parameter controlling many metabolic and signalling pathways in living cells. Recombinant fluorescent pH indicators (pHluorins) have come into vogue...Full Text Available

International Nuclear Information System (INIS)

Carbon monoxide can be produced in severe accidents from interaction of ex-vessel molten core with concrete. Depending on the particular core-melt scenario, the type of concrete and geometric factors affecting the interaction, the quantities of carbon monoxide produced can vary widely, up to several volume percent in the containment. Carbon monoxide is a combustible gas. The carbon monoxide thus produced is in addition to the hydrogen produced by metal-water reactions and by radiolysis, and represents a possibly significant contribution to the combustible gas inventory in the containment. Assessment of possible accident loads to containment thus requires knowledge of the combustion properties of both CO and H_2 in the containment atmosphere. Extensive studies have been carried out and are still continuing in the nuclear industry to assess the threat of hydrogen in a severe reactor accident. However the contribution of carbon monoxide to the ...

Energy Technology Data Exchange (ETDEWEB)

Schemata for modelling combustion processes do not yet include reaction rates for oxygenated fuels like methylal (DMM) which is considered as an additive or replacement for diesel due to its low sooting propensity. Density functional theory (DFT) studies of the possible reaction pathways for different dissociation steps of methylal are presented. Cleavage of a hydrogen bond to the methoxy group or the central carbon atom were simulated at the BLYP/6-311++G{sup **} level of theory. The results are compared to the experiment when dissociating and/or ionising DMM with femtosecond pulses. (author) 1 fig., 1 tab., 1 ref.

Science.gov (United States)

Inhibition of the phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is an appealing method for decreasing the immunoresistance and augmenting T cell-mediated immunotherapy. A major impediment to this strategy is the impact of conventional PI3K/mTOR pathway inhibitors on T cell function. In particular, rapamycin, is a well-known immunosuppressant that can decrease the activity of the PI3K/mTOR pathway in tumor cells, but also has a profound inhibitory effect on T cells. Here we show that Honokiol, a natural dietary product isolated from an extract of seed cones from Magnolia grandiflora, can decrease PI3K/mTOR pathway-mediated immunoresistance of glioma, breast and prostate cancer cell lines, without affecting critical proinflammatory T cell functions. Specifically, we show that at doses sufficient to down-regulate levels of phospho-S6 and the negative immune regulator B7-H1 ...

British Library Electronic Table of Contents (United Kingdom)

This study deals with the neutronics analysis of the current core configuration of a 3MW TRIGA Mark-II research reactor at Atomic Energy Research Establishment (AERE), Savar, Dhaka, Bangladesh and validation of the results by benchmarking with the experimental, operational and available Safety Analysis Report (SAR) values. The comprehensive neutronics code system SRAC was used to develop a versatile and accurate full-core model of the TRIGA core. The model represents in detail all components of the core with literally no physical approximation. All fresh fuel and control elements as well as the vicinity of the core were precisely described. Cross-section data library generated from JENDL-3.2 were used. The validation of the model against benchmark experimental results is presented. The SRA...

International Nuclear Information System (INIS)

Fuel Management at the Fast Flux Test Facility (FFTF) involves more than just the usual ex-core and in-core management of standard fuel and non-fuel components between storage locations and within the core since it is primarily an irradiation test facility. This mission involves testing an ever increasing variety of fueled and non-fueled experiments, each having unique requirements on the reactor core as well as having its own individual impact on the reload design. This paper describes the fuel management process used by the Westinghouse Hanford Company Core Engineering group that has led to the successful reload design of nine operating cycles and the irradiation of over 120 tests.

International Nuclear Information System (INIS)

TAPP-3 and 4 reactors use large number of Self Powered Neutron Detectors (SPNDs) for Neutronic lower measurement and control. To perform in-situ calibration of these detectors in select locations and to validate the reactor physics codes which predict flux at various points in the core, traveling in-core probes (TIP) are required. The TIP assembly consists of a miniature neutron sensitive detector. The detector is driven in and out of core using a mechanism which facilitates positioning of the detector anywhere inside a vertical tube (Central carrier tube of any of the six select Vertical Flux Units) in the core. TIP is driven through retractable feed mechanism for a stroke of 13 m. This paper describes the developmental efforts and the operational feedback of the retractable feed mechanism for the stroke of 13 m used at TAPP 3 and 4 reactor. (author)

Energy Technology Data Exchange (ETDEWEB)

Live cores were obtained from five reservoirs using special precautions to prevent contamination by exogenous microorganisms and minimize exposure to oxygen. The depths from which the cores were obtained ranged from 2,705 ft to 6,568 ft. Core plugs were cut radially from live cores, encased in heat-shrink plastic tubes, placed in core holders, and fitted with inlets and outlets. Nutrient additions stimulated the in-situ microbial population to increase, dissolve stratal material, produce gases, and release oil. Reduction in flow through the core plugs was observed in some cases, while in other cases flow was increased, probably due to the dissolution of carbonates in the formation. A field demonstration of the ability of the in-situ microbial population to increase oil recovery by blocking the more permeable zones of the reservoir is currently underway. This ...

International Nuclear Information System (INIS)

To obtain reactor physics parameters for high-moderation mixed-oxide (MOX) cores, Nuclear Power Engineering Corporation (NPEC), the French Atomic Commission (CEA), and their industrial partners have conducted a MOX core physics experimental program called MISTRAL with the EOLE critical facility of the Cadarache research center. This program consists of four high-moderation cores and was successfully completed in July 2000. This paper describes the analysis results of MISTRAL-3 that is a homogeneous full MOX cylindrical core (H/HM = 6.2) with an 80-cm height and a 59-cm diameter consisting of 1388 standard pressurized water reactor-type MOX fuel rods of 7.0 wt% plutonium-enrichment in a square pitch of 1.39 cm. NPEC has been analyzing the experimental results by using the SRAC and MVP code systems. SRAC and MVP calculate the nuclear core characteristics correctly for the ...

Energy Technology Data Exchange (ETDEWEB)

Subsurface and surface coalfires are a serious problem in many coal-producing countries. Combustion can occur within the coal seams (underground or surface), in piles of stored coal, or in spoil dumps at the surface. While consuming a non renewable energy source, coalfires promote several environmental problems. Among all GHGs that are emitted from coalfires, CO2 is the most significant because of its high quantity. In connection to this environmental problem, the core aim of the present research is to develop a hyperspectral remote sensing and radiative transfer based model that is able to estimate CO2 concentration (ppmv) from coalfires. Since 1960s remote sensing is being used as a tool to detect and monitoring coalfires. With time, remote sensing has proven a reliable tool to identify and monitor coalfires. In the present study multi-temporal, multi-sensor and multi-spectral thermal remote sensing data are being used to detect and monitor ...

Energy Technology Data Exchange (ETDEWEB)

The results of the 2006 investigation of contaminant sources at Navarre, Kansas, clearly demonstrate the following: {sm_bullet} Sources of carbon tetrachloride contamination were found on the Navarre Co-op property. These sources are the locations of the highest concentrations of carbon tetrachloride found in soil and groundwater at Navarre. The ongoing groundwater contamination at Navarre originates from these sources. {sm_bullet} The sources on the Co-op property are in locations where the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) never conducted grain storage operations. {sm_bullet} No definitive sources of carbon tetrachloride were identified on the portion of the current Co-op property formerly used by the CCC/USDA. {sm_bullet} The source areas on the Co-op property are consistent with the locations of the most intense Co-op operations, both historically and at present. The Co-op historically stored carbon tetrachloride for ...

Energy Technology Data Exchange (ETDEWEB)

The U.S. Department of Energy (DOE) and the U.S. Council for Automotive Research (composed of automakers Ford, General Motors, and Chrysler) announced in January 2002 a new cooperative research effort. Known as 'FreedomCAR' (derived from 'Freedom' and 'Cooperative Automotive Research'), it represents DOE's commitment to developing public/private partnerships to fund high-risk, high-payoff research into advanced automotive technologies. Efficient fuel cell technology, which uses hydrogen to power automobiles without air pollution, is a very promising pathway to achieving the ultimate vision. The new partnership replaces and builds upon the Partnership for a New Generation of Vehicles initiative that ran from 1993 through 2001. The Advanced Power Electronics and Electric Machines (APEEM) subprogram within the FreedomCAR and Vehicle Technologies Program provides support and guidance for many cutting-edge ...

Energy Technology Data Exchange (ETDEWEB)

Three dimensional computational fluid dynamic (CFD) calculations of a typical prismatic very high temperature gas-cooled reactor (VHTR) were conducted to investigate the influence of gap geometry on flow and temperature distributions in the reactor core using commercial CFD code FLUENT. Parametric calculations changing the gap width in a whole core length model of fuel and reflector columns were performed. The simulations show the effects of core by-pass flows in the heated core region by comparing results for several gap widths including zero gap width. The calculation results underline the importance of considering inter-column gap width for the evaluation of maximum fuel temperatures and temperature gradients in fuel blocks. In addition, it is shown that temperatures of core outlet flow from gaps and channels are strongly affected by the gap width of by-pass flow in the reactor ...

International Nuclear Information System (INIS)

The Fast Flux Test Facility (FFTF) was designed to test fast-reactor fuels and other nonfuel materials. In its 37 reactor cycles of operations, the FFTF reactor has performed very well and successfully completed all the irradiation testings with an operating efficiency factor as high as 98%. Since FFTF is an experimental reactor, its core loading changed from cycle to cycle. Depending on the number of test assemblies in the core and their location, the core loading can change significantly from an essentially homogeneous core loading to a relatively nonhomogeneous or even highly localized heterogeneous loading. Consequently, the core reload design and initial criticality analyses were required for each operating cycle. The zero power initial critical control rod bank height was predicted before each reactor startup. The initial critical prediction depends on the reactivity ...

Energy Technology Data Exchange (ETDEWEB)

JAERI has been performing transient core thermal-hydraulic test program. In the program, authors performed BWR/ABWR DBE simulation tests with a test facility, which can simulate BWR/ABWR transients. The test facility has a 4 x 4 bundle core simulator with 15-rod heaters and one non-heated rod. Through the tests, authors quantified the thermal safety margin for core cooling. In order to quantify the thermal safety margin, authors collected experimental data on post-CHF. The data are essential for the evaluation of clad temperature transient when core heat-up occurs during DBEs. In comparison with previous post-CHF tests, present experiments were performed in much wider experimental condition, covering high clad temperature, low to high pressure and low to high mass flux. Further, data at wider elevation (lower to higher elevation of core) were obtained in the present experiments, ...

UK PubMed Central (United Kingdom)

We present a technique for identifying the amino acids responsible for a loss of immunoreactivity in response to treating an antigen with a chemical modifier. This is of particular interest...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This guide is applied for the reload pattern's formation for mirror symmetry of a core room and in accordance with the Control Cell core technique (of the english Control Cell Core - CCC) for the PRESTO-B code. (Author)

International Nuclear Information System (INIS)

Purpose : To obtain an emergency core cooling device in a FBR type reactor by utilizing heat pipes which are not actuated at usual operation condition but actuated reliably upon emergency. Constitution : A system for injecting heat medium into heat pipes is provided. By injecting the heat medium into the heat pipes upon emergency to actuate the heat pipes, the reactor core is cooled. During normal reactor operation, the inside of the heat pipes is evacuated from a vacuum pump and no heat medium is filled therein, whereby unnecessary heat loss during the normal operation can be prevented. (Ikeda, J.).

International Nuclear Information System (INIS)

Properties of unique parity states in odd-proton (_7_7Ir, _7_9Au) and odd-neutron nuclei (_7_8Pt) are investigated in the framework of the interacting boson-fermion approximation model. The core (boson)-particle (fermion) interaction is represented by a quadrupole-quadrupole interaction and an exchange term, which takes into account the effects of the Pauli exclusion principle. The even-even core nucleus is described in terms of the IBA-1 hamiltonian. The change in the properties of the corresponding odd-A nuclei can be interpreted in terms of a transition of the core hamiltonian between the O(6) and SU(3) limiting cases. (orig.).

Energy Technology Data Exchange (ETDEWEB)

The WWR-SM reactor at the Institute of Nuclear Physics of the Academy of Sciences (INP AS) in Uzbekistan was converted to 6-tube IRT-4M LEU (19.7%) fuel in 2009. Presently, INP intends to also use IRT-4M 8-tube FA, and a safety analysis for these 'mixed' (8-tube and 6-tube FA) cores is required by the regulatory authorities. This paper presents results of control rod ejection transient analysis for these mixed cores

International Nuclear Information System (INIS)

The 2- and 8-azido trimer 5'-triphosphate photoprobes of 2-5A have been enzymatically synthesized from [#gamma#-"3"2P]2-azidoATP and [#alpha#-"3"2P]8-azidoAPT by 2-5A synthetase from rabbit reticulocyte lysates. Identification and structural determination of the 2- and 8-azido adenylate trimer 5'-triphosphates were accomplished by enzymatic hydrolyses with T2 RNase, snake venom phosphodiesterase, and bacterial alkaline phosphatase. Hydrolysis products were identified by HPLC and PEI-cellulose TLC analyses. The 8-azido photoprobe of 2-5A displaces p_3A_4["3"2P]pCp from RNase L with affinity equivalent to p_3A_3. The 8-azido photoprobe also activates RNase L to hydrolyze poly(U)["3"2P]pCp 50% at 7 /times/ 10/sup /minus/9/ M in core-cellulose assays. The 2- and 8-azido photoprobes and authentic p_3A_3 activate RNase L to cleave 28S and 18S rRNA to specific cleavage products at 10/sup /minus/9/ M in rRNA cleavage assays. The nucleotide binding ...

UK PubMed Central (United Kingdom)

Why we sleep remains one of the enduring unanswered questions in biology. At its core, sleep can be defined behaviorally as a homeostatically regulated state of reduced movement and sensory...Full Text Available

Science.gov (United States)

... Composite sandwich panels with fiber reinforced plastic (FRP) faces and low 3 density foam cores are fast becoming the structural material of ...

Energy Technology Data Exchange (ETDEWEB)

The Reduced-Moderation Water Reactor (RMWR) is a next generation water-cooled reactor, based on the experienced light water reactor (LWR) technology, aiming at effective utilization of uranium resources, high burn-up and long operation cycle and plutonium multiple recycling. These characteristics can be achieved by the high conversion ratio from {sup 238}U to {sup 239}Pu resulted from the higher neutron energy spectrum in comparison to conventional LWRs. Considering the extension of LWR utilization, Japan Atomic Energy Research Institute (JAERI) started the research on it in 1997 and then started a collaboration in the conceptual design study with the Japan Atomic Power Company (JAPC) in 1998, under technical cooperation with three Japanese reactor vendors. In the core design study of the RMWR, several basic core designs with the high conversion ratio more than 1 and the negative void reactivity coefficient have been proposed, and then, ...