UK PubMed Central (United Kingdom)

Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between follicular melanocytes, keratinocytes,...Full Text Available

UK PubMed Central (United Kingdom)

Background: CD1d belongs to a family of antigen presenting molecules that are structurally and distantly related to the classic major histocompatibility complex class I (MHC I)...Full Text Available

Science.gov (United States)

In mice, coat pigmentation requires a stem cell (SC) system in which the survival, proliferation, and differentiation of melanocytes (MCs) are regulated by microenvironments in hair follicles (HFs). In vitro systems are required to analyze the behavior of single melanocyte stem cells (MCSCs) and their potential to form SC systems in vivo. We describe here an experimental system for the isolation, self-renewal, and differentiation of MCSCs, as well as an in vivo reconstitution assay for assessing their potential. Using Dct(tm1(Cre)Bee)/CAG-CAT-GFP mice, we show that, in the presence of stem cell factor and basic fibroblast growth factor and the XB2 feeder cell line, purified MCSCs can undergo clonogenic proliferation, resulting in c-Kit(low) side scatter(low) cells. In culture, these cells maintain their capacity to differentiate and reconstitute an MCSC system in HFs. As these cells are present in the upper part of the HF near the ...

UK PubMed Central (United Kingdom)

Here, we provide the first study of prolactin (PRL) and prolactin receptor (PRLR) expression during the nonseasonal murine hair cycle, which is, in contrast to sheep, comparable with the human scalp...Full Text Available

UK PubMed Central (United Kingdom)

Human skin is a local source of corticotropin-releasing hormone (CRH) and expresses CRH and CRH receptors (CRH-R) at mRNA and protein levels. Epidermal melanocytes respond to CRH by induction...Full Text Available

UK PubMed Central (United Kingdom)

G6PD activity was assayed in 20 Sardinian heterozygotes for G6PD deficiency and related to that of LDH and MDH. One of these heterozygotes showed a deficient phenotype in all her follicles, while the...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Although the intracellular ultrastructural processing of epidermal growth factor (EGF) and its receptor have been described in cell culture systems, very few studies have examined this phenomenon in intact tissues. We have examined the ultrastructural and biochemical handling of (/sup 125/I)EGF in the epidermis and hair follicle bulb of intact, viable, 3- to 5-day-old rat skin the EGF receptor distribution of which has already been documented and in which EGF has been shown to be biologically active. After incubation of explants with 10 nM (/sup 125/I)EGF for 2.5 h at 25 degrees or 37 degrees C, radiolabel was detected over the basal cells of the epidermis and hair follicle outer root sheath, confirming previous light microscope observations. More specifically, silver grains were observed near coated and uncoated plasma membrane and coated membrane invaginations, Golgi apparatus, lysosomal structures, ...

CERN Document Server

After presenting three ways of defining a bulge component in disc galaxies, we introduce the various types of bulges, namely the classical bulges, the boxy/peanut bulges and the disc-like bulges. We then discuss three specific topics linked to bulge formation and evolution, namely the coupled time evolution of the bar, buckling and peanut strengths; the effect of velocity anisotropy on peanut formation; and bulge formation via bar destruction.

UK PubMed Central (United Kingdom)

Segments of the chick basilar papilla were isolated and maintained in culture medium. The sensory hair bundle of individual hair cells was observed with light microscopy and stimulated with a water...Full Text Available

International Nuclear Information System (INIS)

Methods of sample treatment in XRF analysis of hair are studied in view of the effect on analytical results. A new method is proposed based on the incomplete ashing of hair followed by pellet preparation. Its suitability is estimated on the XRF analysis of real hair samples collected from 4 healthy adults. (author) 12 refs.; 4 figs.; 1 tab.

International Nuclear Information System (INIS)

A bulge-disk decomposition is made for 737 spiral and lenticular galaxies drawn from a Sloan Digital Sky Survey galaxy sample for which morphological types are estimated. We carry out the bulge-disk decomposition using the growth curve fitting method. It is found that bulge properties, effective radius, effective surface brightness, and also absolute magnitude, change systematically with the morphological sequence; from early to late types, the size becomes somewhat larger, and surface brightness and luminosity fainter. In contrast, disks are nearly universal, their properties remaining similar among disk galaxies irrespective of detailed morphologies from S0 to Sc. While these tendencies were often discussed in previous studies, the present study confirms them based on a large homogeneous magnitude-limited field galaxy sample with morphological types estimated. The systematic change of bulge-to-total ...

International Nuclear Information System (INIS)

Human hair fibers experience tensile forces during grooming and styling processes. The tensile response of hair is hence of considerable interest to the cosmetics industry. In this study, in situ tensile characterization studies have been carried out in an atomic force microscope (AFM) on different hair under different conditions. A custom-built AFM sample stage allows hair fibers to be loaded in tension. A technique to locate and image the same control area at different strains has been developed to study the changes in morphology that occur with deformation. Virgin Caucasian, Asian and African hair were studied to understand the differences between different ethnic hair types. Also, the tensile response and morphological changes of virgin, chemically damaged and conditioner-treated Caucasian hair after soaking were compared against the ...

International Nuclear Information System (INIS)

We present new results from BRAVA, a large-scale radial velocity survey of the Galactic bulge, using M giant stars selected from the Two Micron All Sky Survey catalog as targets for the Cerro Tololo Inter-American Observatory 4 m Hydra multi-object spectrograph. The purpose of this survey is to construct a new generation of self-consistent bar models that conform to these observations. We report the dynamics for fields at the edge of the Galactic bulge at latitudes b = -8 deg. and compare to the dynamics at b = -4 deg. We find that the rotation curve V(r) is the same at b = -8 deg. as at b = -4 deg. That is, the Galactic boxy bulge rotates cylindrically, as do boxy bulges of other galaxies. The summed line-of-sight velocity distribution at b = -8 deg. is Gaussian, and the binned longitude-velocity plot shows no evidence for either a (disk) population with cold dynamics or for a (classical ...

UK PubMed Central (United Kingdom)

Minoxidil induces hair growth in male pattern baldness and prolongs the anagen phase. All-trans retinoic acid (ATRA) has been reported to act synergistically with minoxidil in vivo:...Full Text Available

UK PubMed Central (United Kingdom)

Silver-haired bat rabies virus (SHBRV) infection induces a strong virus-specific immune response in the periphery of the host, but death is common due to the failure to open the blood-brain barrier...Full Text Available

UK PubMed Central (United Kingdom)

Hair is preserved for millennia in permafrost; it enshrines a record of biologic rhythms and offers a glimpse at chronobiology as it was in extinct animals. Here we compare biologic rhythms gleaned...Full Text Available

UK PubMed Central (United Kingdom)

The development of both the mammalian oocyte and the somatic cell compartments of the ovarian follicle is highly coordinated; this coordination ensures that the ovulated oocyte is ready to undergo fertilization...Full Text Available

CERN Document Server

We present a kinematic diagnostic for peanut-shaped bulges in nearly face-on galaxies. The face-on view provides a novel perspective on peanuts which would allow study of their relation to bars and disks in greater detail than hitherto possible. The diagnostic is based on the fact that peanut shapes are associated with a flat density distribution in the vertical direction. We show that the kinematic signature corresponding to such a distribution is a minimum in the fourth-order Gauss-Hermite moment $s_4$. We demonstrate our method on $N$-body simulations of varying peanut strength, showing that strong peanuts can be recognized to inclinations $i \\simeq 30\\degrees$, regardless of the strength of the bar. We also consider compound systems in which a bulge is present in the initial conditions as may happen if bulges form at high redshift through mergers. We show that in this case, because the vertical structure of the ...

UK PubMed Central (United Kingdom)

BACKGROUNDHirsutism is the presence of excess body or facial terminal (coarse) hair growth in females in a male-like pattern, affects 5–15% of women, and is an important...Full Text Available

UK PubMed Central (United Kingdom)

HypothesisBiomarkers, commonly expressed in breast cancer cells, may be correlated with their expression in breast skin of the same subjects.MethodsThe...Full Text Available

UK PubMed Central (United Kingdom)

Background:Alopecia areata (AA) is an immune-mediated form of hair loss that occurs in all ethnic groups, ages, and both sexes. Helicobacter pylori has...Full Text Available

UK PubMed Central (United Kingdom)

Pituitary Fshb concentrations increase markedly and selectively beginning on Postnatal Day 20 in the male rat. To evaluate the factors potentially responsible for this rise...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The propriety of the cosmic no-hair conjecture to the Bianchi-type-IX spacetime is discussed from a quantum cosmological point of view. It is shown that most, but not all, classical universes which are created quantum cosmologically are inflationary. The probability of inflation among such universes is also discussed.

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The possibility of having inflation in a renormalizable cosmological model is investigated. The cosmic no-hair conjecture is proved to hold for all Bianchi types except Bianchi type IX. By the use of a conformal transformation on the metric we show that these models are equivalent to the ones described by the Einstein-Hilbert action for gravity minimally coupled to a set of scalar fields with inflationary potentials. Henceforth, we prove that inflationary solutions behave as attractors in solution space, making it a natural event in the evolution of such models.

International Nuclear Information System (INIS)

The cosmic no hair theorem is studied in anisotropic brane worlds. Assuming anisotropic Bianchi models with an inflaton field it is shown that, during slow-roll inflation, anisotropy in all Bianchi models except a Bianchi type-IX universe washes out. Brane worlds admit both exponential and power law inflation. We consider here only exponential expansion of the universe. It is found that isotropization occurs much faster in a brane world than in the general theory of relativity.

International Nuclear Information System (INIS)

Photographic surface photometry in the BV system was carried out two Southern SO's galaxies, NGC 2855 and NGC 6771. B and V isophote maps were obtained as well as geometric and integrated parameters as position angles, inclination, diameters, magnitudes and integrated colors. Each luminosity profile was decomposed into bulge and disk contributions, each component being fitted to convenient laws. For NGC 2855 de Vaucouleurs law described well the bulge whereas the disk showed an exponential distribution. For NGC 6771 the barred nuclear bulge as well as the disk was best fitted by exponential laws. Additional luminosity components due to an inner fragmented ring were identified in NGC 2855 and due to both a quite prominent lens and well defined ring in NGC 6771. In this galaxy the minor axis, oriented almost edge-on, present clues of another luminosity component besides the bulge and the thin disk. For ...

UK PubMed Central (United Kingdom)

In the labellar chemosensory hairs of the blowfly, Phormia regina Meigen, stationary amplitudes of the slow potentials induced by salt and sugar stimulations were decreased to 50–80%...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundCalcium homeostasis is a known target of several environmental toxicants including lead and mercury.ObjectiveOur goal was to determine...Full Text Available

Science.gov (United States)

This study was designed to compare the levels of chromium (Cr) and manganese (Mn) in scalp hair, blood, and urine of night blindness in children age ranged (3-7) and (8-12) years of both genders, comparing them to sex- and age-matched controls. A microwave-assisted wet acid digestion procedure, was developed as a sample pretreatment, for the determination of Cr and Mn in biological samples of night blindness children. The proposed method was validated by using conventional wet digestion and certified reference samples of hair, blood and urine. The digests of all biological samples were analyzed for Cr and Mn by electrothermal atomic absorption spectrometry. The results indicated significantly higher levels of Cr, whilst low level of Mn in the biological samples (blood and scalp hair) of male and female night blindness children, compared with control subjects of both genders. These data present guidance to clinicians and ...

UK PubMed Central (United Kingdom)

Albendazole binds to parasite's tubulin inhibiting its glucose absorption. Its common adverse effects are nausea, vomiting, constipation, thirst, dizziness, headache, hair loss and pruritus. Although...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

To reconstruct the profiles of heavy metal levels in the South Ocean ecosystem of Antarctica, the concentrations of lead (Pb), copper (Cu), arsenic (As), cadmium (Cd), and zinc (Zn) in seal hairs and lake sediments spanning the past 1500 years from Fildes Peninsula of King George Island and in weathering lake sediments from Nelson Island of West Antarctica were determined. The lead contents in the seal hairs and the weathering sediments show a sharp increase since the late 1800s, very likely due to anthropogenic contamination from modern industries. After the 1980s, the Pb content in seal hairs dropped by one-third, apparently due to the reduced usage of leaded gasoline in the Southern Hemisphere. Copper arises mainly from the weathering process, and its level may be substantially affected by climatic conditions. The concentrations of Cd, As, and Zn do not show any clear temporal trends.

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To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls. All PCOS cases (n = 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women (n = 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample t tests. Polycystic ovarian morphology was defined by at least 12 follicles 2-9 mm in diameter and/or an ovarian volume greater than 10 cm{sup 3}. Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted P = 1.3 x 10{sup -16}; calculated ovarian volume 8.8 cm{sup 3} [5.0, 15.5] vs 5.1 cm{sup 3} [2.5, 10.3], unadjusted P = 3.0 x 10{sup -7}; peripheral follicle ...

International Nuclear Information System (INIS)

Photometric and kinematic observations of the peculiar S0 galaxy IC 4767, the X-galaxy, are presented. At various intensities the bulge of this galaxy looks like a normal spheroidal system with elliptical isophotes, a well-defined rectangle, and a peanut-shaped or X-shaped structure with components aligned at oblique angles to the major axis. The observations reveal a rapidly rotating inner disk of gas and dust which is nearly aligned with the major axis. The presence of gaseous emission alone suggests an accretion event. The stars in the outer regions of the X-component are rotating nearly as rapidly as the gas in the main disk, indicating that they are in relatively circular orbits. The five most prominent peanut-shaped bulges all have several nearby companions, evidence that the peanut deformity is due to interaction between galaxies. An analogy with the formation mechanism proposed for polar-ring galaxies suggests how an X-shaped component ...

Science.gov (United States)

Pinealectomy completely prevented gonadal regression as well as reduction in body weight and white adipose tissue content of the gonadal and retroperitoneal fat deposits in male meadow voles transferred from long to short day lengths. Pineal influences on pelage characteristics depended on which parameter was assessed. For instance, the increase in guard hair length observed in short-day control voles was blocked by pinealectomy; however, a similar increase in underhair length was unaffected by removal of the pineal gland. Photoperiod-dependent changes in fat deposition, testicular activity, and guard hair length presumably rely on altered pineal secretory activity to transduce the effects of day length on the neuroendocrine axis; however, mechanisms independent of pineal activity may be capable of mediating photoperiodic control of underhair growth. PMID:2979644

International Nuclear Information System (INIS)

In this short note we report our finding that within the context of alternative version of the Brans-Dicke theory (for #omega# #>=# -3/2, where #omega# is the Brans-Dicke parameter) the anisotropic Bianchi type cosmological models evolve towards the de Sitter isotropic universe. In short it is shown that during inflation there is no difference between the Brans-Dicke theory and General Relativity. Our result can thus be viewed as a generalization of the Wald's theorem for General Relativity. (author). 5 refs.

CERN Document Server

Because Spitzer is an Earth-trailing orbit, losing about 0.1 AU/yr, it is excellently located to perform microlens parallax observations toward the Magellanic Clouds (LMC/SMC) and the Galactic bulge. These yield the so-called ``projected velocity'' of the lens, which can distinguish statistically among different populations. A few such measurements toward the LMC/SMC would reveal the nature of the lenses being detected in this direction (dark halo objects, or ordinary LMC/SMC stars). Cool Spitzer has already made one such measurement of a (rare) bright red-clump source, but warm (presumably less oversubscribed) Spitzer could devote the extra time required to obtain microlens parallaxes for the more common, but fainter, turnoff sources. Warm Spitzer could observe bulge microlenses for 38 days per year, which would permit up to 24 microlens parallaxes per year. This would yield interesting information on the disk mass function, particularly old ...

CERN Document Server

The vertical profiles of disc galaxies are built by the material trapped around stable periodic orbits, which form their "skeletons". According to this, the knowledge of the stability of the main families of periodic orbits in appropriate 3D models, can predict possible morphologies for edge-on disc galaxies. In a pilot survey we compare the orbital structures which lead to the appearance of "peanuts" and "X"-like features with the edge-on profiles of three disc galaxies (IC 2531, NGC 4013 and UGC 2048). The subtraction from the images of a model representing the axisymmetric component of the galaxies reveals the contribution of the non-axisymmetric terms. We find a direct correspondence between the orbital profiles of 3D bars in models and the observed main morphological features of the residuals. We also apply a simple unsharp masking technique in order to study the sharpest features of the images. Our basic conclusion is that the morphology of the boxy "bulges" ...

International Nuclear Information System (INIS)

Core radii and central surface brightnesses of bulges and elliptical galaxies are measured using CCD photometry obtained with the Canada-France-Hawaii Telescope (scale = 0''.22 pixel"-"1; seeing = 0''.45--1''.0 FWHM). The correlations between core parameters are derived and compared for ellipticals, bulges, dwarf spheroidal galaxies, dwarf irregular galaxies, and globular clusters. The results are as follows. 1. Ihe data confirm the existence of well-defined correlations between the core parameters of elliptical galaxies. More luminous ellipticals have larger core radii r/sub c/ and lower central surface brightnesses #mu#/sub 0v/. Galaxies with larger core radii have larger central velocity dispersions. The small, bright core of M32 is normal for a galaxy of M/sub B/ = -15.2. Radio ellipticals and brightest cluster galaxies satisfy the correlations. 2. The bulges of disk galaxies are basically similar to elliptical ...

British Library Electronic Table of Contents (United Kingdom)

Abstract: We tested the effects on the early-stage wound healing of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber matrices cultured with hair follicular cells. PHBV only, PHBV/collagen, and PHBV/gelatin at a 7/3 weight ratio were produced by electrospinning, and their in vitro cell culture and in vivo wound healing as biological dressings were examined. In cell attachment and growth on matrices, dermal sheath (DS) cells attached to hydrophilic PHBV/collagen and PHBV/gelatin faster than hydrophobic PHBV at the early incubation stage (up to 6 h). From 6- to 24-h incubation, PHBV/collagen showed the best results in cell culture. Furthermore, PHBV/collagen cocultured for 3-5 days with DS and epithelial outer root sheath (ORS) cells expressed more extracellular materials, such a...

Science.gov (United States)

The function of the hypothalamo-pituitary-gonadal system has been studied in 118 males with different stages of alcoholism. Comparison with the control group has shown decreased levels of interstitial cell stimulating hormone (ICSH), follicle-stimulating hormone (FSH), and testosterone, and elevated concentrations of prolactin (Prl). Differences in the parameters of hormonal activity expressed in a varying degree of a decrease in FSH, ICSH, and testosterone, and a Prl elevation are related to change in mutual regulatory influences between the gonads and hypothalamo-pituitary complex. The most informative parameters were concentrations of Prl and testosterone (considering elevation in the former and reduction in the latter hormone) and the ratio of their concentrations. Difference of these parameters in each group (corresponding to the stages of alcoholism) may be used as an additional diagnostic criterion of chronic alcohol intoxication. PMID:3434080

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It is shown that all contracting, spatially homogeneous, orthogonal Bianchi cosmologies that are sourced by an ultra-stiff fluid with an arbitrary and, in general, varying equation of state asymptote to the spatially flat and isotropic universe in the neighbourhood of the big crunch singularity. This result is employed to investigate the asymptotic dynamics of a collapsing Bianchi type IX universe sourced by a scalar field rolling down a steep, negative exponential potential. A toroidally compactified version of M*-theory that leads to such a potential is discussed and it is shown that the isotropic attractor solution for a collapsing Bianchi type IX universe is supersymmetric when interpreted in an 11-dimensional context.

CERN Document Server

The Galactic Exoplanet Survey Telescope (GEST) will observe a 2 square degree field in the Galactic bulge to search for extra-solar planets using a gravitational lensing technique. This gravitational lensing technique is the only method employing currently available technology that can detect Earth-mass planets at high signal-to-noise, and can measure the frequency of terrestrial planets as a function of Galactic position. GEST's sensitivity extends down to the mass of Mars, and it can detect hundreds of terrestrial planets with semi-major axes ranging from 0.7 AU to infinity. GEST will be the first truly comprehensive survey of the Galaxy for planets like those in our own Solar System.

International Nuclear Information System (INIS)

An experimental study on superplastic forming behaviors and microstructure characters of commercial magnesium alloy sheet AZ31B is presented in this paper. The main experimental results show that the commercial magnesium alloy AZ31B sheet has superplastic capability. For the received sheet without any pre-processing, the maximum elongation is 295%. The dynamic recrystallization and grain refinement can be found, In the case of temperature =# 350 deg. C. The superplastic behaviors can be improved by controlling the dynamic recrystallization and grain refinement. Some experimental results of free superplastic bulging are presented in this paper. The results show that influence of temperature on forming capability is much less than the influences of temperature on elongation. In addition, the maximum principle strain.

International Nuclear Information System (INIS)

Stellar rotation velocities and velocity dispersions have been measured along the major and minor axes of NGC 4594 with the Canada-France-Hawaii Telescope. The observations show the kinematic signature of a nuclear disk of stars superposed on the bulge (Fig. 1). Apart from its larger size, this is similar to the nucleus of M31. It rotates rapidly: the apparent rotation curve reaches an inner maximum of V 231 #+-# 7 km s"-"1 at r = 5.''0. The apparent velocity dispersion falls from #sigma# = 250 #+-# 7 km s"-"1 at the center to 181 #+-# 6 km s"-"1 at r = 3.''7. (author).

International Nuclear Information System (INIS)

We study the line widths in the [O III]#lambda#5007 and H#alpha# lines for two groups of planetary nebulae in the Milky Way bulge based upon spectroscopy obtained at the Observatorio Astronomico Nacional in the Sierra San Pedro Martir (OAN-SPM) using the Manchester Echelle Spectrograph. The first sample includes objects early in their evolution, having high H#beta# luminosities, but [O III]#lambda#5007/H#beta# < 3. The second sample comprises objects late in their evolution, with He II #lambda#4686/H#beta#>0.5. These planetary nebulae represent evolutionary phases preceding and following those of the objects studied by Richer et al. in 2008. Our sample of planetary nebulae with weak [O III]#lambda#5007 has a line width distribution similar to that of the expansion velocities of the envelopes of asymptotic giant branch stars and shifted to systematically lower values as compared to the less evolved objects studied by Richer et al. The sample with strong He II ...

British Library Electronic Table of Contents (United Kingdom)

The use of indigenous bacterial root endophytes with biocontrol activity against soil-borne phytopathogens is an environmentally-friendly and ecologically-efficient action within an integrated disease management framework. The earliest steps of olive root colonization by Pseudomonas fluorescens PICF7 and Pseudomonas putida PICP2, effective biocontrol agents (BCAs) against Verticillium wilt of olive (Olea europaea L.) caused by the fungus Verticillium dahliae Kleb., are here described. A gnotobiotic study system using in vitro propagated olive plants, differential fluorescent-protein tagging of bacteria, and confocal laser scanning microscopy analysis have been successfully used to examine olive roots?Pseudomonas spp. interactions at the single-cell level. In vivo simultaneous visualization...

Science.gov (United States)

Calcitonin gene-related peptide (CGRP) was localized by an immunocytochemical technique in the thyroid-parathyroid complexes of rat, guinea pig, rabbit, and in normal human thyroids and parathyroids. Human medullary carcinomas and parathyroid adenomas were also studied. In man and all animal species examined CGRP was present in the parafollicular cell, however, in guinea pigs only in small amounts. Except in rabbits, presence of CGRP was demonstrated in nerves of the thyroid and parathyroid capsule as well as in the nerve fibers of the capsular blood vessels. In the thyroid of guinea pigs CGRP was also noted in nerve fibers and in blood vessel walls between follicles. CGRP was also present in the parathyroid glands of rat and man, in nerve fibers localized between parathyroid cells. In rabbit the parafollicular cells between parathyroid cells also expressed CGRP immunoreactivity. No CGRP was noted in the parathyroids of the guinea pig. The proximity of parathyroid ...

Energy Technology Data Exchange (ETDEWEB)

This study was carried out to evaluate the biochemical and morphological effects of ionizing radiation on ovary. Immature mice (ICR, 3 week-old) were irradiated at a dose of LD{sub 80(30)} at KAERI. The ovaries were collected after 6 hours, 12 hours, 1 day, and 2 days post irradiation. To analyze the morphological changes, histological staining with hematoxylin-eosin, immuno- histochemical preparation using in situ 3'-end labeling was performed. DNA fragmentation analysis and flowcytometric evaluation of DNA extracted from whole ovary were performed. As a result of DNA fragmentation analysis, DNA fragments with 185, 370, and 555 base pairs were clearly shown at 6 hours post irradiation. The percentage of A{sub 0} cell cycle was significantly increased in the irradiated group than control. In situ 3'-end labeled follicles were increased at 6 hours post irradiation. The radiation-induced follicular atresia was taken place via an apoptotic ...

CERN Document Server

Cosmological hydrodynamical simulations as well as observations indicate that spiral galaxies are comprised of five different components: dark matter halo, stellar disc, stellar bulge, gaseous disc and gaseous halo. While the first four components have been extensively considered in numerical simulations of binary galaxy mergers, the effect of a hot gaseous halo has usually been neglected even though it can contain up to 80% of the total gas within the galaxy virial radius. We present a series of hydrodynamic simulations of major mergers of disc galaxies, that for the first time include a diffuse, rotating, hot gaseous halo. Through cooling and accretion, the hot halo can dissipate and refuel the cold gas disc before and after a merger. This cold gas can subsequently form stars, thus impacting the morphology and kinematics of the remnant. Simulations of isolated systems with total mass M~10^12Msun show a nearly constant star formation rate of ~5Msun/yr if the hot ...

CERN Document Server

Two dimensional Fourier spectra of near-infrared images of galaxies provide a powerful diagnostic tool for the detection of spiral arm modulation in stellar disks. Spiral arm modulation may be understood in terms of interference patterns of outgoing and incoming density wave packets or modes. The brightness along a spiral arm will be increased where two wave crests meet and constructively interfere, but will be decreased where a wave crest and a wave trough destructively interfere. Spiral arm modulation has hitherto only been detected in grand design spirals (such as Messier 81). Spiral arm amplitude variations have the potential to become a powerful constraint for the study of galactic dynamics. We illustrate our method in two galaxies: NGC 4062 and NGC 5248. In both cases, we have detected trailing and leading m=2 waves with similar pitch angles. This suggests that the amplification mechanism is the WASER type II. In this mechanism, the bulge region reflects ...

CERN Document Server

The stellar disc kinematics in a sample of fifteen intermediate- to late-type edge-on spiral galaxies are studied using a dynamical modeling technique. The sample covers a substantial range in maximum rotation velocity and deprojected face-on surface brightness and contains seven spirals with either a boxy- or peanut-shaped bulge. Dynamical models of the stellar discs are constructed using the disc structure from $I$-band surface photometry and rotation curves observed in the gas. The differences in the line-of-sight stellar kinematics between the models and absorption line spectroscopy are minimized using a least-squares approach. The modeling constrains the disc surface density and stellar radial velocity dispersion at a fiducial radius through the free parameter $\\sqrt{M/L}$ $(\\sigma_{\\rm z}/\\sigma_{\\rm R})^{-1}$, where $\\sigma_{\\rm z}/\\sigma_{\\rm R}$ is the ratio of vertical and radial velocity dispersion and $M/L$ the disc mass-to-light ratio. For ...

Energy Technology Data Exchange (ETDEWEB)

The microstructures and mechanical properties of the AZ31 Mg tubes fabricated by one-pass forward piercing tube extrusion operated at 250-400 C and 10{sup -2}-10{sup 0} s{sup -1} are examined. The grain size is refined from the initial {proportional_to}75 {mu}m grain size down to {proportional_to}1.5 {mu}m. The room temperature tensile elongation along the extrusion direction also increases from {proportional_to}13% for the as-received billet up to 51%. The highest superplastic elongation of 610% was obtained as tensile loaded at 300 C and 2 x 10{sup -4} s{sup -1}, and high strain rate superplasticity of 406% and 502% was achieved at 300 C and 400 C with a high strain rate of 1 x 10{sup -2} s{sup -1}. Preliminary hydroforming or tube bulging at room temperature has demonstrated the feasibility. Hydroforming at elevated temperature of 200 C or above should exhibit much more promising results, utilizing the capability of LTSP and HSRSP of the extruded tubes. (orig.)

CERN Document Server

For purposes of designing targeted cataclysmic variable (CV) detection surveys and interpreting results of other projects with many CV detections such as the ChaMPlane Survey, we have created a model of the CV distribution in the Galaxy. It is modeled as a warped, flared exponential disk with a gaussian vertical distribution. Extinction is based on a detailed Galactic dust and gas model. A luminosity function for CVs is also incorporated, based on a smoothed version of published data. We calculate predicted field detection rates as a function of the limiting magnitude expected for the detecting system (i.e. WIYN/Hydra or NOAO 4m/Mosaic). Monte-Carlo techniques are used to assess statistical fluctuations in these rates. We have created maps of the expected CV distribution for the full non-bulge Galactic plane (20

CERN Document Server

We examine the observable properties of simulated barred galaxies including radial mass profiles, edge-on structure and kinematics, bar lengths and pattern speed evolution for detailed comparison to real systems. We have run several simulations in which bars are created through inherent instabilities in self-consistent simulations of a realistic disc+halo galaxy model with a disc-dominated, flat rotation curve. These simulations were run at high (N=20M particles) and low (N=500K) resolution to test numerical convergence. We determine the pattern speeds in simulations directly from the phase angle of the bar versus time and the Tremaine-Weinberg method. Fundamental dynamics do not change between the high and low resolution, suggesting that convergence has been reached in this case. We find the higher resolution is needed to simulate structural and kinematic properties accurately. The edge-on view of the higher-resolution system clearly shows the bending instability and formation of a ...

International Nuclear Information System (INIS)

The main aims of the study were: 1) the evaluation of iron and zinc status in women of Lodz aged 18-45 years, 2) adaptation of the whole body counter to in vivo measurements absorption of iron given to the gastro-intestinal tract of volunteers and 3) in rat model estimation iron bioavailability from fortified wheat flour combined with products usually consumed in Poland. During five months investigations thirty seven women were examined each one twice in two months interval. Following variables were measured: iron and zinc in blood serum, in public and scalp hair and in food, taste acuity score, serum ferritin, hemoglobin, total iron binding capacity, red blood cells, mean corpuscular concentration and corpuscular volume. Prevalence of iron deficiency and iron deficient anemia were assessed by two models in terms of the depression of serum ferritin and hemoglobin concentrations. 64 refs, 6 figs, 23 tabs.

International Nuclear Information System (INIS)

Comprehensive investigation has been made into the application of the polymerization hardening by radiation, particularly electron beam, to the composites of polymers and other materials. The report is divided into four parts, namely 1) characteristics and problems of the reaction of curing by radiation polymerization, 2) improvement of the bonding capability of high molecular weight materials, 3) bonding by radiation, and 4) composites made by the impregnation and polymerization hardening of monomers. The first part includes the effects of dose rate, temperature rise during the hardening, the peculiarity of electron beam irradiation at high dose rate, reaction environment and additive effects. Main conclusions are as follows: caution must be taken to the amount of residual double bonds because they affect the quality of hardened polymers; the polymerization hardening reaction at high dose rate cannot be analogized by that at low dose rate; and the presence of the inhibitors of radical ...

Energy Technology Data Exchange (ETDEWEB)

We have presented evidence that the functional thyroid follicles (follicular units, FU) which are formed in grafts of monodispersed rat thyroid cells, and hence the thyroid tumors which later develop in such grafts, are clonal in origin. Recent studies have been designed to investigate: whether cell number-dependent inhibition of promotion-progression is mediated by remote hormonal feed-back, local cell-cell interactions, or both; the cell population kinetics of the clonogen subpopulation during goitrogenesis and goiter involution; and the effect of prolonged exposure to high levels of TSH (thyrotropin) on the capacity of the clonogens to give rise to functional FU. The results indicate that local cell-cell interactions play an important role in the cell number-dependent suppression of neoplastic promotion-progression. They also show that if sufficient thyroid cells are grafted, the thyroid-pituitary axis can be reestablished in thyroidectomized rats fed normal ...

Energy Technology Data Exchange (ETDEWEB)

Ovarian function was evaluated in 11 women 16 to 43 years of age at treatment who received doxorubicin, cyclophosphamide, and high doses of methotrexate with or without radiotherapy in adjuvant therapy of soft tissue sarcoma. Five women (16-33 yr old) who received chemotherapy alone or combined with radiotherapy only at sites distant from the ovaries (chest wall, thigh, and leg) had minimal menstrual irregularities or temporary cessation of menses during therapy; cyclic menses returned promptly after therapy. Gonadotropin levels (expressed as means +/- SD) (follicle-stimulating hormone (FSH), 10 +/- 15 mlU/ml; luteinizing hormone (LH), 10 +/- 4 mlU/ml) and 17 ..beta..-estradiol (E/sub 2/) levels (means +/- SD, 208 +/- 147 pg/ml) were normal. By contrast, 4 older women (ages 36-43 yr) who received similar treatment developd persistent amenorrhea with postmenopausal levels of gonadotropin (FSH, 109 +/- 29 mlU/ml; LH, 72 +/- 19 mlU/ml) and E/sub 2/ (19 +/- 8 pg/ml). ...

Energy Technology Data Exchange (ETDEWEB)

Eddy current testing (ECT) method is widely used as the non-destructive evaluation (NDE) of the various kinds of material degradation occurring in nuclear power plants (NPPs) components including steam generator (SG) tubes. Detection of any defects or flaws in the steam generator tubes in the early stage is very important in maintenance of NPP for its primary role as the pressure boundary with thin wall thickness. Although the ECT technique provides lots of information for a SG management, it has a generic problem in its reliability due to a low ability in detect of small defects and some difficulty in a signal analysis. For the improvement of these shortcomings in conventional ECT, profile-MRPC (motorized rotating pancake coil) ECT technology was developed in KAERI. The key of this new technology is the development of new eddy current probes, designated as a diagnostic probe (D-probe). The D-probe is furnished with a simultaneous dual function of a defect detection and shape changes ...

International Nuclear Information System (INIS)

A morphological survey of barred galaxies is made to investigate the frequency of occurrence, nature, and size distributions of bars, lenses, inner and outer rings, and global spiral structure. The 121 brightest available barred galaxies are examined on Sky Survey copy plates, and on deeper and larger-scale plates, with the following main results.1. Lenses and inner rings are components of major importance in barred galaxies, occurring, respectively, in 54% of SBO--SBa, and 76% of SBab--SBc galaxies. Few early-type galaxies have rings; almost no late-type ones have lenses.2. There is an intimate connection between bars and lenses: in 17 of 20 galaxies with both components, the bar exactly fills the lens in one dimension.3. We suggest that lenses originate as bars, through an unknown process which makes some bars evolve away to a nearly axisymmetric state. Several properties of the proposed process are deduced. We emphasize the possible importance of internal processes of secular ...

International Nuclear Information System (INIS)

We have previously reported that FSH stimulates flux of 45Ca2+ into cultured Sertoli cells from immature rats via voltage-sensitive and voltage-independent calcium channels. In the present study, we show that this effect of FSH does not require cholera toxin (CT)- or pertussis toxin (PT)-sensitive guanine nucleotide binding (G) protein or activation of adenylate cyclase (AC). Significant stimulation of 45Ca2+ influx was observed within 1 min, and maximal response (3.2-fold over basal levels) was achieved within 2 min after exposure to FSH. FSH-stimulated elevations in cellular cAMP paralleled increases in 45Ca2+ uptake, suggesting a possible coupling of AC activation to 45Ca2+ influx. (Bu)2cAMP, however, was not able to enhance 45Ca2+ uptake over basal levels at a final concentration of 1000 microM, although a concentration-related increase in androstenedione conversion to estradiol was evident. Exposure of Sertoli cells to CT (10 ng/ml) consistently stimulated basal levels of ...

Energy Technology Data Exchange (ETDEWEB)

To assess the contribution of adrenal-derived androgens in women with hirsutism, adrenal scintigrams under dexamethasone suppression (DS) were performed on 35 women with increasing facial or body hair and irregular or absent menses. Based upon the DS regimen chosen (8 mg/d for 2 days or 4 md/d for 7 days before the injection of 6..beta..-(/sup 131/I)iodomethylnorcholesterol), three imaging patterns were identified. The first was the absence of uptake before 3 days (8-mg DS) or before 5 days (4-mg DS) after injection. This imaging pattern was seen in 17 of the 35 patients studied and was considered normal. The second pattern was bilateral uptake earlier than 3 days (8-mg DS regimen) or 5 days (4-mg DS) after injection. This was seen in 13 of the 35 patients and was interpreted as bilateral early visualization. Adrenal-vein catheterization performed on six patients with this pattern showed increased adrenal-vein testosterone. The third pattern, observed in five ...

International Nuclear Information System (INIS)

In this review, we demonstrate the developmental appearance, structural features, and reorganization of transient cerebral zones and structures in the human fetal brain using a correlative histological and MRI analysis. The analysis of postmortem aldehyde-fixed specimens (age range: 10 postovulatory weeks to term) revealed that, at 10 postovulatory weeks, the cerebral wall already has a trilaminar appearance and consists of: (1) a ventricular zone of high cell-packing density; (2) an intermediate zone; (3) the cortical plate (in a stage of primary consolidation) with high MRI signal intensity. The anlage of the hippocampus is present as a prominent bulging in the thin limbic telencephalon. The early fetal telencephalon impar also contains the first commissural fibers and fornix bundles in the septal area. The ganglionic eminence is clearly visible as an expanded continuation of the proliferative ventricular zone. The basal ganglia showed an initial aggregation of ...