Segments of the chick basilar papilla were isolated and maintained in culture medium. The sensory hairbundle of individual haircells was observed with light microscopy and stimulated with a water...Full Text Available
HypothesisBiomarkers, commonly expressed in breast cancer cells, may be correlated with their expression in breast skin of the same subjects.MethodsThe...Full Text Available
BackgroundStem cells divide to reproduce themselves and produce differentiated progeny. A fundamental problem in human biology has been the inability to measure how often stem cells...Full Text Available
Transient receptor potential (TRP) ion channels have been implicated in detecting chemical, thermal and mechanical stimuli in organisms ranging from mammals to Caenorhabditis elegans....Full Text Available
The sensations of sound and motion generated by the inner ear are controlled by the brain through extensive centripetal innervation originating within the brain stem. In the semicircular canals, brain...Full Text Available
Congenital woolly hair is a disorder with structural defects of the hair shafts. Curled hairs are noticed at birth or soon after birth and often improve with age. Some cases of woolly hairs are associated...Full Text Available
Abstract: We tested the effects on the early-stage wound healing of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber matrices cultured with hair follicular cells. PHBV only, PHBV/collagen, and PHBV/gelatin at a 7/3 weight ratio were produced by electrospinning, and their in vitro cell culture and in vivo wound healing as biological dressings were examined. In cell attachment and growth on matrices, dermal sheath (DS) cells attached to hydrophilic PHBV/collagen and PHBV/gelatin faster than hydrophobic PHBV at the early incubation stage (up to 6 h). From 6- to 24-h incubation, PHBV/collagen showed the best results in cell culture. Furthermore, PHBV/collagen cocultured for 3-5 days with DS and epithelial outer root sheath (ORS) cells expressed more extracellular materials, such a...
G6PD activity was assayed in 20 Sardinian heterozygotes for G6PD deficiency and related to that of LDH and MDH. One of these heterozygotes showed a deficient phenotype in all her follicles, while the...Full Text Available
... on the presence of leukocytes in the mammary epithelial tissue [11], temporal differentiation of the epithelial cells during ... of the gland and were separated from the epithelial tissue by bundles of co...
The hair follicle cycle successively goes through the anagen, catagen, telogen, and latency phases, which correspond, respectively, to hair growth, arrest, shedding, and absence before a new anagen...Full Text Available
Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between follicular melanocytes, keratinocytes,...Full Text Available
Although the intracellular ultrastructural processing of epidermal growth factor (EGF) and its receptor have been described in cell culture systems, very few studies have examined this phenomenon in intact tissues. We have examined the ultrastructural and biochemical handling of ["1"2"5I]EGF in the epidermis and hair follicle bulb of intact, viable, 3- to 5-day-old rat skin the EGF receptor distribution of which has already been documented and in which EGF has been shown to be biologically active. After incubation of explants with 10 nM ["1"2"5I]EGF for 2.5 h at 25 degrees or 37 degrees C, radiolabel was detected over the basal cells of the epidermis and hair follicle outer root sheath, confirming previous light microscope observations. More specifically, silver grains were observed near coated and uncoated plasma membrane and coated membrane invaginations, Golgi apparatus, lysosomal structures, and ...
Although the intracellular ultrastructural processing of epidermal growth factor (EGF) and its receptor have been described in cell culture systems, very few studies have examined this phenomenon in intact tissues. We have examined the ultrastructural and biochemical handling of (/sup 125/I)EGF in the epidermis and hair follicle bulb of intact, viable, 3- to 5-day-old rat skin the EGF receptor distribution of which has already been documented and in which EGF has been shown to be biologically active. After incubation of explants with 10 nM (/sup 125/I)EGF for 2.5 h at 25 degrees or 37 degrees C, radiolabel was detected over the basal cells of the epidermis and hair follicle outer root sheath, confirming previous light microscope observations. More specifically, silver grains were observed near coated and uncoated plasma membrane and coated membrane invaginations, Golgi apparatus, lysosomal structures, ...
The hair follicle develops from the primitive embryonic epidermis as a result of complex epithelial-mesenchymal interactions. The full follicle, consisting of epithelial cylinders under control of a...Full Text Available
In mice, coat pigmentation requires a stem cell (SC) system in which the survival, proliferation, and differentiation of melanocytes (MCs) are regulated by microenvironments in hair follicles (HFs). In vitro systems are required to analyze the behavior of single melanocyte stem cells (MCSCs) and their potential to form SC systems in vivo. We describe here an experimental system for the isolation, self-renewal, and differentiation of MCSCs, as well as an in vivo reconstitution assay for assessing their potential. Using Dct(tm1(Cre)Bee)/CAG-CAT-GFP mice, we show that, in the presence of stem cell factor and basic fibroblast growth factor and the XB2 feeder cell line, purified MCSCs can undergo clonogenic proliferation, resulting in c-Kit(low) side scatter(low) cells. In culture, these cells maintain their capacity to differentiate and ...
It is very well known that the CANDU reactor has positive Coolant Void Reactivity (CVR), which is most important criticisms about CANDU. The most recent innovations based on using a thin absorbent Hafnium shell in the central bundle element were successfully been applied to the Advanced CANDU Reactor (ACR) project. The paper's objective is to analyze elementary lattice cell effects in applying such methods to reduce the CVR. Three basic fuel designs in their corresponding geometries were chosen to be compared: the ACR-1000TM, the RU-43 (developed in INR Pitesti) and the standard CANDU fuel. The bundle geometry influence on void effect was also evaluated. The WIMS calculations proved the Hafnium absorber suitability (in the latest 'shell design') to achieve the negative CVR target with great accuracy for the ACR-1000 fuel bundle design than for the other two projects. (authors)
Methods of sample treatment in XRF analysis of hair are studied in view of the effect on analytical results. A new method is proposed based on the incomplete ashing of hair followed by pellet preparation. Its suitability is estimated on the XRF analysis of real hair samples collected from 4 healthy adults. (author) 12 refs.; 4 figs.; 1 tab.
Human hair fibers experience tensile forces during grooming and styling processes. The tensile response of hair is hence of considerable interest to the cosmetics industry. In this study, in situ tensile characterization studies have been carried out in an atomic force microscope (AFM) on different hair under different conditions. A custom-built AFM sample stage allows hair fibers to be loaded in tension. A technique to locate and image the same control area at different strains has been developed to study the changes in morphology that occur with deformation. Virgin Caucasian, Asian and African hair were studied to understand the differences between different ethnic hair types. Also, the tensile response and morphological changes of virgin, chemically damaged and conditioner-treated Caucasian hair after soaking were compared against the ...
The use of indigenous bacterial root endophytes with biocontrol activity against soil-borne phytopathogens is an environmentally-friendly and ecologically-efficient action within an integrated disease management framework. The earliest steps of olive root colonization by Pseudomonas fluorescens PICF7 and Pseudomonas putida PICP2, effective biocontrol agents (BCAs) against Verticillium wilt of olive (Olea europaea L.) caused by the fungus Verticillium dahliae Kleb., are here described. A gnotobiotic study system using in vitro propagated olive plants, differential fluorescent-protein tagging of bacteria, and confocal laser scanning microscopy analysis have been successfully used to examine olive roots?Pseudomonas spp. interactions at the single-cell level. In vivo simultaneous visualization...
Follicular unit transplant (FUT) is one of the surgical procedures which has been recently used to repigment a stable vitiligo patch. Single-hair FUT was done for a 30-year-old male with stable vitiligo...Full Text Available
Minoxidil induces hair growth in male pattern baldness and prolongs the anagen phase. All-trans retinoic acid (ATRA) has been reported to act synergistically with minoxidil in vivo:...Full Text Available
The appearance of hair plays an important role in people’s overall physical appearance and self-perception. With today’s increasing life-expectations, the desire to look youthful plays...Full Text Available
Silver-haired bat rabies virus (SHBRV) infection induces a strong virus-specific immune response in the periphery of the host, but death is common due to the failure to open the blood-brain barrier...Full Text Available
The etiology of alopecia areata (AA), a putative autoimmune disease characterized by sudden hair loss, has remained obscure. It is not understood, how the characteristic inflammatory infiltrate that...Full Text Available
Background: CD1d belongs to a family of antigen presenting molecules that are structurally and distantly related to the classic major histocompatibility complex class I (MHC I)...Full Text Available
Hair is preserved for millennia in permafrost; it enshrines a record of biologic rhythms and offers a glimpse at chronobiology as it was in extinct animals. Here we compare biologic rhythms gleaned...Full Text Available
This study was performed to investigate the association between hair mineral levels and nutrient intakes, age, and BMI in female adults who visited a woman's clinic located in Seoul. Dietary intakes...Full Text Available
Skin and hair phenotypes are powerful cues in human communication. They impart much information, not least about our racial, ethnic, health, gender and age status. In the case of the latter parameter,...Full Text Available
Here, we provide the first study of prolactin (PRL) and prolactin receptor (PRLR) expression during the nonseasonal murine hair cycle, which is, in contrast to sheep, comparable with the human scalp...Full Text Available
In order to better understand the molecular mechanisms of human hair growth control and to test hair growth-modulatory drugs, appropriate in vitro models are required. Here, we report the long-term...Full Text Available
A design concept is presented for an in-bundle gamma densitometer system for measurement of subchannel average fluid density and void fraction in rod or tube bundles. This report describes (1) the application of the design concept to the Thermal-Hydraulic Test Facility (THTF) electrically heated rod bundle; and (2) results from tests conducted in the THTF.
The results of an experimental study of axial and crossflow velocity in a 7-pin wire wrapped bundle similar for FFTF fuel bundles are reported. The results are compared with the forced crossflow model of the COBRA-III C computer program. (JWR)
The compressive and torsional buckling behavior of carbon nanotube bundles at room temperature is examined with classical molecular dynamics simulation. The critical compressive load and stiffness of a single carbon nanotube in the bundle are found to be similar to those of individual carbon nanotubes. However, the critical torsional moment and stiffness of a single carbon nanotube in the bundle are found to be higher than those of individual carbon nanotubes. In addition, this study demonstrates that van der Waals interactions between the nanotubes in the bundle significantly affect the critical compressive load of the nanotube bundle.
The main aims of the study were: 1) the evaluation of iron and zinc status in women of Lodz aged 18-45 years, 2) adaptation of the whole body counter to in vivo measurements absorption of iron given to the gastro-intestinal tract of volunteers and 3) in rat model estimation iron bioavailability from fortified wheat flour combined with products usually consumed in Poland. During five months investigations thirty seven women were examined each one twice in two months interval. Following variables were measured: iron and zinc in blood serum, in public and scalp hair and in food, taste acuity score, serum ferritin, hemoglobin, total iron binding capacity, red blood cells, mean corpuscular concentration and corpuscular volume. Prevalence of iron deficiency and iron deficient anemia were assessed by two models in terms of the depression of serum ferritin and hemoglobin concentrations. 64 refs, 6 figs, 23 tabs.
BACKGROUNDHirsutism is the presence of excess body or facial terminal (coarse) hair growth in females in a male-like pattern, affects 5–15% of women, and is an important...Full Text Available
The electrical responses of the neurons associated with the various types of chemosensory hairs of the blowfly, Phormia regina Meigen, following stimulation by chemical and mechanical...Full Text Available
Background:Alopecia areata (AA) is an immune-mediated form of hair loss that occurs in all ethnic groups, ages, and both sexes. Helicobacter pylori has...Full Text Available
To reconstruct the profiles of heavy metal levels in the South Ocean ecosystem of Antarctica, the concentrations of lead (Pb), copper (Cu), arsenic (As), cadmium (Cd), and zinc (Zn) in seal hairs and lake sediments spanning the past 1500?years from Fildes Peninsula of King George Island and in weathering lake sediments from Nelson Island of West Antarctica were determined. The lead contents in the seal hairs and the weathering sediments show a sharp increase since the late 1800s, very likely due to anthropogenic contamination from modern industries. After the 1980s, the Pb content in seal hairs dropped by one-third, apparently due to the reduced usage of leaded gasoline in the Southern Hemisphere. Copper arises mainly from the weathering process, and its level may be substantially affected...
The mapping of the magnetic flux bundle from the center cell to the Plasma Potential Control plates (PPC) on the end fan of the Tandem Mirror Experiment Upgrade (TMX-U), was improved by the addition of trim coils (12,000 amp-turns) on each side of each end fan next to the pump beam magnetic shields. The coils' axes are oriented perpendicular to the machine centerline. These coils made the necessary corrections to the field-line mapping, while keeping the field in the nearby pump beam magnetic shield below the saturation threshold. This paper briefly describes the problem, discusses the design as it evolved, and presents the results of the field testing. A brief description of the improvement in the machine performance is also included.
The tube bundle arrangement is suitable as reheating section of a steam generator in combination with a gas-cooled reactor. For any high-temperature section with a straightline type tube bundle, there is one inlet and one outlet collecting main; these two are arranged one opposite to the other and diametrically to the tube bundle. There are a number of lines from the inlet collecting main to the outlet collecting main; these lines are arranged axially one on top of the other and run around the tube bundle helically several times. (GL) 891 GL/GL 892 MB.
The propriety of the cosmic no-hair conjecture to the Bianchi-type-IX spacetime is discussed from a quantum cosmological point of view. It is shown that most, but not all, classical universes which are created quantum cosmologically are inflationary. The probability of inflation among such universes is also discussed.
The propriety of the cosmic no-hair conjecture to the Bianchi-type-IX spacetime is discussed from a quantum cosmological point of view. It is shown that most, but not all, classical universes which are created quantum cosmologically are inflationary. The probability of inflation among such universes is also discussed.
The possibility of having inflation in a renormalizable cosmological model is investigated. The cosmic no-hair conjecture is proved to hold for all Bianchi types except Bianchi type IX. By the use of a conformal transformation on the metric we show that these models are equivalent to the ones described by the Einstein-Hilbert action for gravity minimally coupled to a set of scalar fields with inflationary potentials. Henceforth, we prove that inflationary solutions behave as attractors in solution space, making it a natural event in the evolution of such models.
The possibility of having inflation in a renormalizable cosmological model is investigated. The cosmic no-hair conjecture is proved to hold for all Bianchi types except Bianchi type IX. By the use of a conformal transformation on the metric we show that these models are equivalent to the ones described by the Einstein-Hilbert action for gravity minimally coupled to a set of scalar fields with inflationary potentials. Henceforth, we prove that inflationary solutions behave as attractors in solution space, making it a natural event in the evolution of such models.
The cosmic no hair theorem is studied in anisotropic brane worlds. Assuming anisotropic Bianchi models with an inflaton field it is shown that, during slow-roll inflation, anisotropy in all Bianchi models except a Bianchi type-IX universe washes out. Brane worlds admit both exponential and power law inflation. We consider here only exponential expansion of the universe. It is found that isotropization occurs much faster in a brane world than in the general theory of relativity.
The prototypic pituitary hormone prolactin (PRL) exerts a wide variety of bioregulatory effects in mammals and is also found in extrapituitary sites, including murine skin. Here, we show by reverse...Full Text Available
A parallel bundle of transmembrane (TM) alpha-helices surrounding a central pore is present in several classes of ion channel, including the nicotinic acetylcholine receptor (nAChR). We have modeled...Full Text Available
The chlorophyll fluorescence characteristics of mesophyll and bundle-sheath thylakoids from plant species with the C4 dicarboxylic acid pathway of photosynthesis were investigated using flow cytometry....Full Text Available
Indian PHWRs are designed to operate with natural uranium (NU) as the main fuel. Earlier in the initial fresh core, to achieve flux flattening and hence to operate the reactor at design rated power, limited number of depleted uranium bundles were loaded in the central portion of the core. Presently even in fresh core about 40 % of the core is loaded with depleted uranium bundles (?0.6 wt % 235U) from the consideration of conserving the natural uranium fuel. This is achieved by loading most of the depleted bundles in the peripheral locations of the channels. Successful operation with large number of DU bundles in the fresh core has been proven in MAPS - 2 and MAPS - 1cores after EMCCR as well as in TAPP - 4. In these three reactors 100 % FP was possible even with 40 % DU bundles in the core. In TAPP-4 and 3 initial core, depleted bundles of 0.36 wt % 235U are ...
We present in this paper the computer code BACCHUS, to analyze the thermal-hydraulics in a rod bundle in single or two-phase flow regime. The model is 2-D and uses the porous body approach. The two-phase model is an extension of the classical homogeneous model, and includes a differential non-equilibrium equation. Results are shown for the extension of the boiling region in a 19-pin bundle.
We present in this paper the computer code BACCHUS, to analyze the thermal-hydraulics in a rod bundle in single or two-phase flow regime. The model is 2-D and uses the porous body approach. The two-phase model is an extension of the classical homogeneous model, and includes a differential non-equilibrium equation. Results are shown for the extension of the boiling region in a 19-pin bundle. (orig.).
In the labellar chemosensory hairs of the blowfly, Phormia regina Meigen, stationary amplitudes of the slow potentials induced by salt and sugar stimulations were decreased to 50–80%...Full Text Available
Human skin is a local source of corticotropin-releasing hormone (CRH) and expresses CRH and CRH receptors (CRH-R) at mRNA and protein levels. Epidermal melanocytes respond to CRH by induction...Full Text Available
BackgroundCalcium homeostasis is a known target of several environmental toxicants including lead and mercury.ObjectiveOur goal was to determine...Full Text Available
Objective: The aim of this study was to characterize using flow cytometry cultured human primary keratinocytes isolated from the epidermis and hair follicles by different methods. Methods:...Full Text Available
This study was designed to compare the levels of chromium (Cr) and manganese (Mn) in scalp hair, blood, and urine of night blindness in children age ranged (3-7) and (8-12) years of both genders, comparing them to sex- and age-matched controls. A microwave-assisted wet acid digestion procedure, was developed as a sample pretreatment, for the determination of Cr and Mn in biological samples of night blindness children. The proposed method was validated by using conventional wet digestion and certified reference samples of hair, blood and urine. The digests of all biological samples were analyzed for Cr and Mn by electrothermal atomic absorption spectrometry. The results indicated significantly higher levels of Cr, whilst low level of Mn in the biological samples (blood and scalp hair) of male and female night blindness children, compared with control subjects of both genders. These data present guidance to clinicians and ...
Behavioral responses to labellar stimulation with 19 L-amino acids were predicted on the basis of electrophysiological responses of largest labellar hairs. With the exceptions alanine, aspartic...Full Text Available
Albendazole binds to parasite's tubulin inhibiting its glucose absorption. Its common adverse effects are nausea, vomiting, constipation, thirst, dizziness, headache, hair loss and pruritus. Although...Full Text Available
The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers. TRPV1 was originally described on sensory neurons...Full Text Available
To reconstruct the profiles of heavy metal levels in the South Ocean ecosystem of Antarctica, the concentrations of lead (Pb), copper (Cu), arsenic (As), cadmium (Cd), and zinc (Zn) in seal hairs and lake sediments spanning the past 1500 years from Fildes Peninsula of King George Island and in weathering lake sediments from Nelson Island of West Antarctica were determined. The lead contents in the seal hairs and the weathering sediments show a sharp increase since the late 1800s, very likely due to anthropogenic contamination from modern industries. After the 1980s, the Pb content in seal hairs dropped by one-third, apparently due to the reduced usage of leaded gasoline in the Southern Hemisphere. Copper arises mainly from the weathering process, and its level may be substantially affected by climatic conditions. The concentrations of Cd, As, and Zn do not show any clear temporal trends.
We prove a cosmic no-hair theorem for Bianchi models in power-law inflation. Provided that the potential of an inflaton {phi} is exp({minus}{lambda}{kappa}{phi}) with 0{le}{lambda}{lt} {radical}2/3 , we find that the isotropic power-law solution is the unique attractor for any initially expanding Bianchi-type models except type IX. For Bianchi type IX, this conclusion is also true if the initial ratio of the vacuum energy to the maximum three-curvature is larger than one half.
This study focuses on the regulation of sucrose transport across the plasmalemma. Initially, we re-examined the use of leaf discs to study the kinetics of phloem loading using Allium cepa leaves. All tissues exhibited the same linear plus saturable profile as Beta vulgaris, except fructose uptake into the inner parenchyma and bundle-sheath cells; in this case the response was linear. These results indicate that all tissues of the leaf retrieve exogenous sucrose such that kinetics from leaf discs cannot be taken to represent phloem loading per se. We continued our study by investigating the influence of internal sugars on sugar transport across the plasmalemma. We found that if internal sugars were manipulated by heat-girdling techniques or DCMU treatment there was no appreciable change in sucrose influx. However, longer term heat-girdling decreased sucrose uptake. These data indicate that carbohydrate partitioning among the chloroplast, ...
CANDU 600 nuclear reactors are usually fuelled with STANDARD (STD), 37 rods fuel bundles. Natural uranium (NU) dioxide (UO_2), is used as fuel composition. A new fuel bundle geometry called CANFLEX (CFX) with 43 rods is proposed and some new fuel composition are considered. Flexibility is the key word for the attempt to use some different fuel geometries and compositions for CANDU 600 nuclear reactors as well as for innovative ACR-700/1000 nuclear reactors. The fuel bundle considered in this paper is CFX-RU-0.90 that encodes the CANFLEX geometry, recycled dioxide uranium (RU) with 0.90% enrichment. The goal of this proposal is ambitious: a higher average discharge burn-up up to 14000 MWd/tU and, for the same amount of generated electric power, reduction in nuclear fuel fabrication, reduction of spent nuclear fuel radioactive waste and reduction of refueling operational work by using fewer bundles. An ...
Full text of publication follows: During calculations of SAR accidents and transients it is necessary to perform steam generator simulation. Best accuracy is 3D transient calculations presented in report. Main outcomes of work was next: 1. There was shown by analysis the applicability of code TRAC (Los-Alamos laboratory) for thermal - hydraulic calculations of horizontal steam generator PGV-1000M. Special nodalization scheme was developed for it purposes. 2. Validation and selection of thermal-hydraulic correlations for improvement of using the code at calculation PGV-1000M were performed. As result Labuntsov formula is recommended for horizontal SG. 3. Calculations of nominal mode operation of PGV-1000M for cross-verification with code STEG (Electrogorsk Research and Engineering Center EREC) during its verification were performed. Solution by TRAC was obtained for transient problem after stabilization time. 4. Development of dynamic SG model as conjugate problem (thermal hydraulic of ...
A pair of bundles is placed in a shuttle tube, which is enclosed by a carriage tube kept inside the Shuttle Transfer Station (STS). It takes about 90 minutes for the spent fuel bundles to travel from the reactor channel to Transfer Magazine (TM). Subsequently, the dry transfer operation takes about 4 minutes. An emergency air cooling flow rate of 600 m3/hr is supplied to cool the spent fuel bundles after they reach the STS, following lapse of 4 minutes of spent fuel dry transfer, in case the bundles are not submerged in the light water in STS. A thermal and hydraulic safety analysis has been done to estimate the maximum sheath temperature, if the spent fuel bundles are stuck at a location of 30 mm below the normal location aligned to the TM port. This position of the spent fuel will have least cooling from the emergency cooling airflow. At the same time, the shuttle tube carrying ...
Critical power at boiling transition is an important factor in a boiling water reactor (BWR) fuel bundle design. Boiling transition under high quality accounts for dryout as the result of the complete disappearance of film flow on a fuel rod. This liquid film vanishing process can be calculated by the liquid film model, which takes into account the evaporation due to heat from the rod surface, liquid film entrainment by steam flow, and liquid droplet deposition. It is known that spacers affect liquid film entrainment and liquid droplet deposition, so the detailed study of spacer effects on hydrodynamic characteristics is necessary for critical power prediction based on the film flow model. Many studies have been conducted to examine spacer effects on liquid film flow. However, most of them are restricted to simple test sections such as a rectangular conduit. There are a few reports on fuel bundle geometry; however the ...
An optimization of fuel bundle geometry using the subchannel code ASSERT is performed in support of Candu fuel design to enhance the thermohydraulics performance. The new bundle design is based on a reference CANFLEX bundle with changes to the centre and inner-ring element diameters and pitch-circle diameters (PCDs) of various element rings. Different methods of varying the PCDs for reaching the optimized geometry are considered in an attempt to minimize the optimization effort. The optimized geometry in the present analysis is the one that maximizes the dryout power and that has simultaneous CHF (critical heat flux) initiation involving more than one subchannel rings. (authors)
Extensive experimental and analytical investigations of fluid flow and heat transfer in gas-cooled rod bundles have been carried out. Different bundle geometries with partially or fully roughened rod surfaces were tested in a carbon dioxide loop. An advanced and comprehensive measuring control and instrumentation are important design features of this experiment. Comprehensive thermal hydraulic subchannel analysis computer codes have been developed in order to assist fuel element design calculation for gas-cooled reactors. The experiments, codes and their verification procedure are described and the results of comparisons between measured and calculated pressure and temperature distributions are given. (orig.).
TRIGA-SSR is a steady state research and material test reactor that has been in operation since 1980. The original TRIGA fuel was HEU (highly enriched uranium) with a U"2"3"5 enrichment of 93 per cent. Almost all TRIGA HEU fuel bundles are now burned-up. Part of the spent fuel was loaded and transferred to US, in a Romania - DOE arrangement. The rest of the TRIGA fuel bundles have to be temporarily stored in the TRIGA facility. As the storage conditions had to be established with caution, neutron and thermal hydraulic evaluations of the storage conditions were required. Some criticality evaluations were made based on the SAR (Safety Analysis Report) data. Fuel constant axial temperature approximation effect is usual for criticality computations. TRIGA-SSR fuel bundle geometry and materials model for SCALE5-CSAS module allows the introduction of a fuel temperature dependency for the entire fuel active height, using different ...
In 1980, I. Morrison proved that slope stability of a vector bundle of rank $2$ over a compact Riemann surface implies Chow stability of the projectivization of the bundle with respect to certain polarizations. We generalized Morrison's result to higher rank vector bundles over compact algebraic manifolds of arbitrary dimension that admit constant scalar curvature metric and have discrete automorphism group. In this article, we give a simple proof for polarizations $\\mathcal{O}_{\\mathbb{P}E^*}(d)\\otimes \\pi^* L^k$, where $d$ is a positive integer, $k \\gg 0$ and the base manifold is a compact Riemann surface of genus $g \\geq 2$.
A two-phase flow regime map is developed experimentally and theoretically for a vertical hexagonal flow channel with and without a 36-finned rod hexagonal bundle. This type of flow channel is of interest to MAPLE-type nuclear research reactors. The flow regime maps are determined by visual observations and observation of waveforms shown by a capacitance-type void fraction meter. The experimental results show that the inclusion of the finned hexagonal bundle shifts the flow regime transition boundaries toward higher water flow rates. Existing flow regime maps based on pipe flow require slight modifications when applied to the hexagonal flow channel with and without a MAPLE-type finned hexagonal bundle. The proposed theoretical model agrees well with experimental results.
A two-phase flow regime map is developed experimentally and theoretically for a vertical hexagonal flow channel with and without a 36-finned rod hexagonal bundle. This type of flow channel is of interest to MAPLE-type nuclear research reactors. The flow regime maps are determined by visual observations and observation of waveforms shown by a capacitance-type void fraction meter. The experimental results show that the inclusion of the finned hexagonal bundle shifts the flow regime transition boundaries toward higher water flow rates. Existing flow regime maps based on pipe flow require slight modifications when applied to the hexagonal flow channel with and without a MAPLE-type finned hexagonal bundle. The proposed theoretical model agrees well with experimental results.
A Real-Time Neutron Radiography (RTNR) system is developed to determine two-phase flow parameters for a vertical co-current two-phase flow channel with a hexagonal finned bundle. Image processing techniques are applied to visualize the two-phase flow, and procedures for measuring flow regime, cross-sectional averaged void fraction, time averaged void fraction, and void distribution for this complex geometry are discussed. The results show that the experimental flow regime map agrees well with an existing flow regime model for a hexagonal fined bundle. The hexagonal finned bundle is observed to significantly affect the void fraction, void migration, and void fluctuation along the axial flow channel.
Pinealectomy completely prevented gonadal regression as well as reduction in body weight and white adipose tissue content of the gonadal and retroperitoneal fat deposits in male meadow voles transferred from long to short day lengths. Pineal influences on pelage characteristics depended on which parameter was assessed. For instance, the increase in guard hair length observed in short-day control voles was blocked by pinealectomy; however, a similar increase in underhair length was unaffected by removal of the pineal gland. Photoperiod-dependent changes in fat deposition, testicular activity, and guard hair length presumably rely on altered pineal secretory activity to transduce the effects of day length on the neuroendocrine axis; however, mechanisms independent of pineal activity may be capable of mediating photoperiodic control of underhair growth. PMID:2979644
The losses of Hg from phenol formaldehyde resin - bound standards and hair samples in neutron activation analysis in case of their irradiation in the water filled nuclear reactor channel is studied. The mean losses of Hg during 20-30 hrs irradiation at (2-3)x10"1"8 n/cm"2 are 15-20% with their stopping at double Al-covers. The mean losses of Hg from standards at 200, 250 and 300 deg C are 30, 61 and 86% respectively and do not occur at 150 deg C after their 5 hour heating. The losses of Hg from hair samples packed in polyethylene tubes through the package walls in experimental conditions are not observed.
In this review, we demonstrate the developmental appearance, structural features, and reorganization of transient cerebral zones and structures in the human fetal brain using a correlative histological and MRI analysis. The analysis of postmortem aldehyde-fixed specimens (age range: 10 postovulatory weeks to term) revealed that, at 10 postovulatory weeks, the cerebral wall already has a trilaminar appearance and consists of: (1) a ventricular zone of high cell-packing density; (2) an intermediate zone; (3) the cortical plate (in a stage of primary consolidation) with high MRI signal intensity. The anlage of the hippocampus is present as a prominent bulging in the thin limbic telencephalon. The early fetal telencephalon impar also contains the first commissural fibers and fornix bundles in the septal area. The ganglionic eminence is clearly visible as an expanded continuation of the proliferative ventricular zone. The basal ganglia showed an ...
Two sets of experiments have been performed in sodium with two seven pin electrically heated bundles: the first with a nominal arrangement, the second with one dummy pin enlarged 20% in diameter in peripheral position. In this paper a rapid review of experimental results and theoretical works, related to the temperature distribution in these geometries, is presented together with a short description of the developed test section technology.
This is a continuation of research that started in July 2007 at the Deep River Science Academy. The research was related to the effects of endplate thickness and misalignment of fuel bundles in the fuel channel on pressure losses of reactor coolant. Based on this research, a new approach to refueling of the CANDU reactor has been developed. It greatly simplifies fuel handling equipment and increases its reliability. It also reduces required staffing, as well as operating and maintenance costs associated with fuel handling. (author)
Heat transfer augmentation by straight grid spacers in rod bundles is studied for single phase flow and for post critical heat flux dispersed flow. The heat transfer effect of swirling grid spacers in single phase flow is also examined. Governing heat transfer mechanisms are analyzed, and predictive formulations are established. For single phase flow, the local heat transfer at a straight spacer and at its upstream or downstream locations are treated separately. 18 refs.
A Real-Time Neutron Radiography (RTNR) system is used to determine two-phase flow parameters for a horizontal co-current two-phase flow channel with a CANDU-type 37 rod bundle. Image processing techniques are applied to visualize the two-phase flow, and to determine flow regime, cross-sectional averaged void fraction, time averaged void fraction, and void distribution. The experimentally determined flow regime map disagrees with existing flow regime models developed for the CANDU-type rod bundles. A new flow regime is observed and designated Large Amplitude Stratified Wavy flow. The results show that the LASW flow regime may be due to a combination of undeveloped flow phenomena, boundary conditions, and circumferential cross flow occurring in the bundle. The rods in the bundle may act as a dampener to the vertical flow and hinders the development of the wave into plug or slug flow by changing the ...
A real-time neutron radiography (RTNR) system is used to determine two-phase flow parameters for a horizontal co-current two-phase flow channel with a cylindrical 37 rod bundle. Image processing techniques are applied to visualize the two-phase flow, and to determine flow regime, cross-sectional averaged void fraction, time averaged void fraction, and void distribution. The experimentally determined flow regime map disagrees with existing flow regime models developed for the cylindrical rod bundles. A new flow regime is observed and designated large amplitude stratified wavy (LASW) flow. The results show that the LASW flow regime may be due to a combination of undeveloped flow phenomena, boundary conditions, and circumferential cross flow occuring in the bundle. The rods in the bundle may act as a dampener to the vertical flow component and hinders the development of the wave into plug or slug flow by ...
A Real-Time Neutron Radiography (RTNR) system is used to determine two-phase flow parameters for a horizontal co-current two-phase flow channel with a CANDU-type 37 rod bundle. Image processing techniques are applied to visualize the two-phase flow, and to determine flow regime, cross-sectional averaged void fraction, time averaged void fraction, and void distribution. The experimentally determined flow regime map disagrees with existing flow regime models developed for the CANDU-type rod bundles. A new flow regime is observed and designated Large Amplitude Stratified Wavy flow. The results show that the LASW flow regime may be due to a combination of undeveloped flow phenomena, boundary conditions, and circumferential cross flow occurring in the bundle. The rods in the bundle may act as a dampener to the vertical flow and hinders the development of the wave into plug or slug flow by changing the ...
Tarapur Atomic Power Station 3 and 4 is a 540 MWe Pressurized Heavy Water Reactor. It uses 37 - element natural Uranium dioxide (UO_2) fuel pellets encapsulated inside the cylindrical sheath and are welded to the end plate at each end. During an postulated accident in which part of the fuel bundle are exposed to very high temperature (no means of heat removal) and other are at lower temperature (coolant temperature) possibility of failure of end plate weld due of thermal stresses developed by these relative temperature cannot be ruled out. In this report an attempt is made to study behaviour of fuel bundle under different temperature loading. Modelling of 37 element fuel bundle was done in ANSYS FEM. System was analysed for various sets of temperature loading. The system was analysed for plasticity and creep as material nonlinearity. The total strain, creep strain and stress increase as the temperature increases in upper ...
Korea Advanced Energy Research Institute (KAERI) started a research project to develop the PHWR (CANDU) nuclear fuel fabrication technology in 1981. Based on the results of the intensive developmental work, several prototype fuel bundles were fabricated and tested in the Hot Test Loop at KAERI continuously in 1983 and 1984. After that, irradiation test and post-irradiation examination were carried out for two KAERI-made fuel bundles at Chalk River Nuclear Laboratories in Canada in 1984. Since the results of in-pile and out-of-pile tests with prototype fuel bundles proved to be satisfactory, 48 additional fuel bundles were loaded in Wolsung reactor (CANDU) in 1984 and 1985, and all of them were discharged without a defect after excellent performance in the power reactor. In 1985, the Korean government decided that KAERI supplies all the fuel necessary for the Wolsung reactor. For the mass production of ...
A one-way coupling system between the plant simulator TRAC/BF1-ENTREE and the subchannel code with the improved cross flow model, NASCA, has been developed. Based on a scenario of turbine trip tests in the Peach Bottom Unit 2, the wide and rapid reactivity insertion transient induced by the system pressure rise was calculated. The pin power distribution in hot bundles was re-constructed considering heterogeneity of the fuel bundle. When the neighboring control blade is withdrawn, NASCA predicted that the steady-state bundle exit void distribution was nearly flat with regardless of the pin power distribution. However, void distributions in the middle and lower bundle regions became complicated depending on the pin power and the two-phase flow regime in each subchannel. The pin power distribution rapidly changed according to traveling of control blades. However, influence in the void distribution was ...
In this short note we report our finding that within the context of alternative version of the Brans-Dicke theory (for #omega# #>=# -3/2, where #omega# is the Brans-Dicke parameter) the anisotropic Bianchi type cosmological models evolve towards the de Sitter isotropic universe. In short it is shown that during inflation there is no difference between the Brans-Dicke theory and General Relativity. Our result can thus be viewed as a generalization of the Wald's theorem for General Relativity. (author). 5 refs.
A survey is presented of studies dealing with radionuclide X-ray fluorescence analysis (RXFA) of impurities in the air, water, soil, sediments and biological materials, mainly blood, urine, hair, soft tissues and bones. Tabulated are lists of published works on RXFA of the air, water and biological materials. (ES).
Dosimetry is evaluated for live-line workers exposed to 50 Hz non-uniform magnetic fields from typical high-voltage transmission lines in the United Kingdom. The configurations involve twin-, triple- and quadruple-conductor transmission line bundles. Scenarios include three worker postures for the twin and triple bundles, and four postures for the quadruple bundle. The postures are selected to simulate worst case scenarios representative of work practices and result in highest values of dosimetric measures in critical organs. Only single-phase bundles are considered, as adjacent bundles of differing phase result only in a small reduction of the dosimetric measures. Reported data include various measures of the electric field and current density induced in tissues, as well as of the current density averaged over 1 cm"2 areas normal to the current flow. A value of this latter quantity ...
In Korea, a manufacturing process for the fabrication of CANDU 37-element fuel bundles was successfully developed between 1981 and 1986. At Korea Atomic Energy Research Institute (KAERI), more than 20,000 fuel bundles were produced up to May 1992, for use in Wolsung-1 power reactor. At the time of the conference, about 15,000 of these fuel bundles had been irradiated in Wolsung-1, and almost all of them had performed well. From 1995, the commercial fuel production program will be transferred to Korea Nuclear Fuel Company, which is building a plant with a capacity of 400 tons of uranium per year. So-called CANFLEX fuel, more appropriate to advanced fuel cycles, is being developed jointly by AECL and KAERI. The paper includes a listing of the current status of the Republic of Korea's nuclear power plants, with planning projections up to the year 2006. 2 tabs.
The SCDAP computer code, which is being developed under the sponsorship of the United States Nuclear Regulatory Commission, models the progression of light water reactor core damage including core heatup, core disruption and debris formation, debris heatup, and debris melting. SCDAP is being used to help identify and understand the phenomena that control core behavior during a severe accident, to help quantify uncertainties in risk assessment analysis, and to support planning and interpretation of severe fuel damage experiments and data. Comparisons between SCDAP calculations and the experimental data showed good agreement. Calculated and measured bundle temperatures for SFD-ST were within 200 K for the entire bundle and within 20 K for maximum cladding temperatures. For ESSI-2, calculated and measured maximum cladding temperatures were within 50 K, and the extensive liquefaction and relocation that was calculated was in agreement with ...
Let $C$ be a curve of genus two. We denote by $SU_C(3)$ the moduli space of semi-stable vector bundles of rank 3 and trivial determinant over $C$, and by $J^d$ the variety of line bundles of degree $d$ on $C$. In particular, $J^1$ has a canonical theta divisor $\\Theta$. The space $SU_C(3)$ is a double cover of $P^8=|3\\Theta|$ branched along a sextic hypersurface, the Coble sextic. In the dual $\\check{P}^8=|3\\Theta|^*$, where $J^1$ is embedded, there is a unique cubic hypersurface singular along $J^1$, the Coble cubic. We prove that these two hypersurfaces are dual, inducing a non-abelian Torelli result. Moreover, by looking at some special linear sections of these hypersurfaces, we can observe and reinterpret some classical results of algebraic geometry in a context of vector bundles: the duality of the Segre-Igusa quartic with the Segre cubic, the symmetric configuration of 15 lines and 15 points, the Weddle quartic ...
Previous flow regime studies have been for horizontal, vertical, and inclined pipe flow. As such, only a few studies have been performed on bundle geometries. The present paper examines the flow regimes for a vertical hexagonal flow channel with and without a finned fuel bundle. This type of a 36 finned rod hexagonal fuel bundle in parallel hexagonal flow channels is used in a MAPLE (Multi- purpose Applied Physics Lattice Experimental) type nuclear reactor. An experiment apparatus was designed consisting of the flow channel, inlet plenum and an air-water separator. The inlet plenum is used to provide a uniform mixture of air and water before entering the hexagonal flow channel. A turbine flow meter is used to determine the water flow rate. The turbine flow meter is calibrated for a low flow range and limits the measurable flow to 50 l/min. Flow pattern observation is determined by a SONY video camera, Real-Time Neutron ...
Bundling of axons and capillarization of the neuroepithelium represent two of the numerous important events in brain development. Prerequisite for these two processes is a directed growth in the matrix-containing intercellular space before a final pattern is formed. The formation of the optical nerve in the region of the retina served as example to show that an extracellular substance with adhesive properties, the glycoprotein fibronectin, plays an important role during bundling and directed growth the axons. However, only small amounts of fibronectin are detected in the region of the capillary sprouts that penetrate into the neuroepithelium. In this area other substances, especially basement membrane components are present, e.g. for anchorage and stabilization. Hence, intercellular substances are also involved in the morphogenesis of the brain. Brain development comprises a great number of individual steps. Their knowledge is the prerequisite ...
Partial bladder outlet obstruction (PBOO) induces remodeling of urinary bladder smooth muscle (detrusor). We demonstrate an increase in bladder wall mass, muscle bundle size, and a threefold increase...Full Text Available
A model was developed to compute concentration of impurities in the WWER 440 steam generator (SG) secondary water along the tube bundle. Calculated values were verified by concentration values obtained from secondary water sample chemical analysis. (orig.). 2 refs.
Experimental and imaging studies in monkeys have outlined various long association fiber bundles within the temporoparietal region. In the present study the trajectory of the middle longitudinal fascicle...Full Text Available
Patellar tendon autografts are not suitable for multibundle ACL reconstruction, a procedure that reportedly enhances postoperative knee stability. Biomechanical studies recommend lateral placement of...Full Text Available
The circulation in microvascularized rib grafts has been compared with that in conventional rib grafts and in those augmented by a direct vascular bundle implantation into the bone grafts. A new experimental model has been designed to correlate vascular perfusion, bone scan patterns, tetracycline labeling, and histological findings in these bone grafts. Posterior microvascularized rib grafts were found to have a circulatory pattern identical to that of the normal rib. Failed microvascularized rib grafts were revascularized more slowly than conventional rib grafts. Vascular bundles implanted into rib grafts remained patent and increased the rate of revascularization. The stripping or preservation of periosteum had no observable effects on the rate or pattern of conventional rib graft revascularization. The circulation in rib grafts was accurately reflected in technetium 99 bone scans, as was the patency of the anastomoses of microvascularized ...
The staring point of the project was to design and construct, by taking the silvicultural point of view into account, a harvesting and processing system especially for energy-wood, containing manually driven bundling harvester, automatizing of the harvester, and automatized loading. The equipment forms an ideal method for entrepreneur`s-line harvesting. The target is to apply the system also for owner`s-line harvesting. The profitability of the system promotes the utilization of the system in both cases. The objectives of the project were: to construct a test equipment and prototypes for all the project stages, to carry out terrain and strain tests in order to examine the usability and durability, as well as the capacity of the machine, to test the applicability of the Eko-Log system in simultaneous harvesting of energy and pulp woods, and to start the marketing and manufacturing of the products. The basic problems of the construction of the ...
We present the results obtained from tests and studies carried out on the model of tube bundles for a PGV-1000 horizontal steam generator that were conducted for experimentally substantiating the design service life of a steam generator tube bundle intended for use at new nuclear power stations equipped with a PGV-1000MKP steam generator. Measures taken to minimize the incipience and development of local corrosion damage to the heat-transfer tubes and ensure their design service life are substantiated and confirmed.
An experimental technique is described which allows for parametric investigations of transient behavior of mobile core materials in a fuel bundle geometry. For the out-of-pile simulation of energy releases resulting from mild TOP- or LOF-accidents the exothermic reaction of an aluminium-oxide-thermite is used. Transient material relocation inside the test section is recorded by X-ray-cinematography. Results of some experiments recently performed close to conditions expected to be achieved during mild TOP-accidents are described in detail.
We propose a new approach to study Koszul cohomology of general $g^r_d$'s on general curves via degenerations and deformations. As an application of this new method, we prove projective normality for general line bundles $L$ on general curves with $h^1(L)\\le1$ and degree greater than roughly $(5/4)g$. This improves the bound in a classical theorem of Green and Lazarsfeld. Also we give some partial results on vanishing of higher syzygies for line bundles with $h^1(L)=1$.
This report describs the input modelling for subchannel analysis of CANFLEX fuel bundle using CASS(Candu thermalhydraulic Analysis by Subchannel approacheS) code which has been developed for subchannel analysis of CANDU fuel channel. CASS code can give the different calculation results according to users' input modelling. Hence, the objective of this report provide the background information of input modelling, the accuracy of input data and gives the confidence of calculation results. (author). 11 refs., 3 figs., 4 tabs.
Experiments have been performed on the electrically heated rod bundles to investigate the characteristics of the boiling transition under flow oscillation (OSBT) during thermal hydraulic instability. After determining the instability threshold power (Q/sub OS/), the electrical power to the test section was increased further up to the threshold power (Q/sub OSBT/) at which it was detected by the thermocouples that the boiling transition (BT) occurred and the heater rod temperature reached 613 K. Experimental results show that Q/sub OSBT/ is larger than Q/sub OS/ by a certain margin, which depends on the test conditions.
Flowsheets for the dissolution of aluminum-clad spent nuclear fuel have been proposed using 0.002 M mercuric nitrate catalyst in 5 to 6 M nitric acid. Previous calculations for flammable gas control during the dissolution of spent nuclear fuel have been extended to cover a range of dissolver purge rates from 40 to 55 scfm. A range of dissolver solution volumes from 12000 to 15000 liters were considered for the large H-Canyon dissolver (6.4D). Depending on the purge rate, anywhere from four to six bundles of MURR fuel can be initially charged to the dissolver (6.4D). For successive charges where the dissolver solution already contains 0.002 M mercury catalyst and the dissolved aluminum from five bundles of MURR fuel, five to nine bundles of additional fuel can be charged depending on the purge rate and the dissolver solution volume. Similar calculations have been performed for the small H-Canyon dissolver (6.1D) for solution ...
''Hair-on-end'' skull changes resembling thalassemia were rarely described in the 1950s and 1960s in children with cyanotic congenital heart diseases; these changes were described almost entirely in patients with tetralogy of Fallot or D-transposition of the great arteries. As these lesions have become correctable, the osseous changes, never common, seem now only to exist in a small number of patients with uncorrectable complex cyanotic congenital heart disease who survive in a chronic hypoxic state. We present two cases: a case of marked marrow expansion in the skull of a 5-year-old boy with uncorrectable cyanotic heart disease studied by CT, and a second case of an 8-year-old with tetralogy of Fallot and pulmonary atresia studied by plain skull radiographs. The true incidence of these findings is unknown. (orig.)
It is shown that all contracting, spatially homogeneous, orthogonal Bianchi cosmologies that are sourced by an ultra-stiff fluid with an arbitrary and, in general, varying equation of state asymptote to the spatially flat and isotropic universe in the neighbourhood of the big crunch singularity. This result is employed to investigate the asymptotic dynamics of a collapsing Bianchi type IX universe sourced by a scalar field rolling down a steep, negative exponential potential. A toroidally compactified version of M*-theory that leads to such a potential is discussed and it is shown that the isotropic attractor solution for a collapsing Bianchi type IX universe is supersymmetric when interpreted in an 11-dimensional context.
Korea Advanced Energy Research Institute (KAERI) started a research project to develop the PHWR (CANDU) nuclear fuel fabrication technology in 1981. Based on the results of the intensive developmental work, several prototype fuel bundles were fabricated and tested in the Hot Test Loop at KAERI continuously in 1983 and 1984. After that, irradiation test and post-irrradiation examination were carried out for two KAERI-made fuel bundles at Chalk River Nuclear Laboratories in Canada in 1984. Since the results of in-pile and out-of-pile tests with prototype fuel bundles proved to be satisfactory, 48 additional fuel bundles were loaded in Wolsung reactor (CANDU) in 1984 and 1985, and all of them were discharged without a defect after excellent performance in the power reactor. In 1985, the Korean government decided that KAERI supplies all the fuel necessary for the Wolsung reactor. For the mass production of ...
One of the limiting contributors to the heat load constraint for a long term spent fuel repository is the decay of americium-241. A possible option to reduce the heat load produced by Am-241 is to eliminate it via transmutation in a light water reactor thermal neutron environment, in particular, by taking advantage of the large thermal fission cross section of Am-242 and Am-242m. In this study we employ lattice loading optimization techniques to define the loadings and arrangements of fuel pins with blended americium and uranium oxide in boiling water reactor bundles, specifically, by defining the incineration of pre-loaded americium as an objective function to maximize americium transmutation. Subsequently, the viability of these optimized lattices is tested by assembling them into bundles with Am-spiked fuel pins and by loading these bundles into realistic three-dimensional BWR core-wide simulations that model multiple ...
A thermal-resistant radiation sensing system using optical fiber has been developed. The system is for monitoring progress of chemical decontamination and able to measure the gamma-ray level in a hot solution of decontamination chemicals in situ. Our sensor head makes use of thermal-resistant NaI (T1) and it is connected to an optical fiber bundle. Scintillation photons pass from the NaI (T1) into the end of the bundle. This part of the system can withstand temperatures of over 100degC. At the far end of the optical fiber bundle, the scintillation photons are converted into fluorescent photons using a wavelength-shifting fiber. These photons are transferred to a distant photomultiplier tube through two thin transparent optical fibers. Furthermore, we propose a self-compensation technique for the dependence of scintillator sensitivity on. This compensation method is based on the correlation between temperature, sensitivity, ...
There are 4 CANDU reactors at Wolsung site together with a spent fuel dry storage associated with unit 1. These CANDU reactors, classified as On-Load Reactor (OLR) for Safeguards application, change 16- 24 fuel bundles with fresh fuel in everyday. Especially, the spent fuel bundles are transferred from spent fuel bays to dry storage throughout a year because of the insufficient capacity of spent fuel pond. Safeguards inspectors verify the spent fuel transfer to meet safeguards purposes according to the safeguards criteria by means of inspector's presence during the transfer campaign. For the verification, 60-80 person-days of inspection (PDIs) are needed during approximately 3 months for each unit. In order to reduce the inspection effort and operators' burden, an Unattended Monitoring System (UMS) was designed and developed by the IAEA for the verification of spent fuel bundles transfers from wet storage ...
A series of 27 reflood experiments has been carried out in a full-length electrically heated rod bundle facility. The primary objective of these tests was to study the effects of a simultaneous upper plenum and downcomer coolant injection and to provide data for the verification of computer codes. The experimental results indicate that an upper plenum injection alone cools the test rods slowly, a simultaneous coolant injection to the downcomer improves cooling significantly, and a downcomer injection alone cools the test rod bundle best if the total value of the coolant flow rate is the same in these three different cases. If the coolant injected to the upper plenum increases the total flow rate, the quench time of the test rods decreases at all elevations. Quenching time and clad temperature histories calculated with the computer codes NORCOOL-I and FLOOD4 are in a reasonable quantitative agreement with experiments in the case of pure ...
One bundle of Hanaro fuel irradiated up to 50%-burnup and cooled for 6 months was transported to IMEF for PIE, which has 6 elements. At first we measured the longitudinal distribution and the rotational distribution of several dominant peaks intensities from the bundle. After dismantling of the bundle we measured the longitudinal distribution of {sup 137}Cs and {sup 134}Cs peaks in each fuel element to see the burn-up feature. And finally we found out the relative number distribution of {sup 137}Cs and {sup 134}Cs for each detection point, which would be used for burn-up calculation. The relative detection efficiency of the scanning system was obtained experimentally by using the {sup 134}Cs peaks. We also checked up the azimuthal difference of peak intensity for each element, which are resulted about 2% of difference. These data will be used for the further analysis of Hanaro fuel performance evaluation. (author)
As a three-year joint university-industry effort, development of a generalized boiling transition analysis method has been started in 2002 aiming at enhanced capabilities of subchannel analysis for a wide variety of BWR-type fuel bundle geometry from ordinary BWR to tight lattice fuel bundles. For this purpose, five dominant factors affecting boiling transition phenomena have been identified on which our efforts of experimentation and numerical analyses are focused. In this report, as the first-year achievement, we will describe a master plan of the development and contents for experimental approaches to construct thermal-hydraulic databases. The databases will be utilized for the developments of constitutive equations to describe the basic characteristics of the elementary processes. The planned experiments are divided into two groups. One is air-water experiments at atmospheric pressure, and the other is steam-water experiments up to 1 MPa. ...
As a three-year joint university-industry effort, development of a generalized boiling transition analysis method has been started in 2002 aiming at enhanced capabilities of subchannel analysis for a wide variety of BWR-type fuel bundle geometry from ordinary BWR to tight lattice fuel bundles. For this purpose, five dominant factors affecting boiling transition phenomena have been identified on which our efforts of experimentation and numerical analyses are focused. In this report, as the first-year achievement, we will describe a master plan of the development and contents for experimental approaches to construct thermal-hydraulic databases. The databases will be utilized for the developments of constitutive equations to describe the basic characteristics of the elementary processes. The planned experiments are divided into two groups. One is air-water experiments at atmospheric pressure, and the other is steam-water experiments up to 1 MPa. ...
This report contains two main subjects. One is the newly started investigation of cross flow boiling in tube bundles. The heat transfer information at this condition is of significant importance to horizontal steam generator design. The other one is the continuation of the research on boiling heat transfer in confined spaces. The research on cross flow boiling in tube bundles has been started. The Freon loop has been modified for higher flow and higher two phase quality. The test section design is finished and is under fabrication presently. The new instrumentation system is also established. The test matrix has been planned. The research on boiling in confined spaces proceeds steadily. This problem is of great importance to the boiling induced corrosion in the steam generator crevices between the tube and the support plate. In the report of 1981, detailed results were presented for analysis of single phase flow, two phase flow, and dryout in ...
The SONACO experiments are conducted on an electrically heated 37-pin rod bundle, immersed in liquid sodium and contained within a hexagonal wrapper. The rig was designed to investigate natural convection cooling for a geometry representative of fast reactor fuel assemblies. Heat can be removed from the test section in several ways, but in this paper only the axial cooling mode is examined. Above the heated bundle is a plenum, at the top of which is a cooling coil containing a separate, forced sodium flow. Heat transfer from the bundle to this cooling coil is effected by means of buoyancy driven circulatory flow in the sodium, and in the axial cooling mode almost all the heat is removed by the coil. This mode is intended to simulate the natural convection cooling of a blocked fuel assembly by way of thermosyphon coupling to the inner pool. In this paper experimental results are presented, for the temperatures measured under ...
The 3D modeling of the thermal hydraulic processes and soluble impurity distribution in the horizontal steam generator PGV-1000 was fulfilled with the thermal hydraulic code STEG. Steady-state operation of horizontal seam generator PGV-1000 was analyzed at nominal power. The modeling of the soluble impurity distribution was fulfilled on the basis of the previous thermal hydraulic modeling results. The processes of the soluble impurity deposition on the steam generator tube bundles and deposits outwash were considered in the mathematical model of the code. The modeling was fulfilled for horizontal steam generators with different peculiarities in construction. Calculation results were compared with experimental results obtained at NPP. The agreement between calculated and experimental results is quite reasonable. Results of modeling are sensible to the peculiarities of the horizontal steam generator construction and consideration of these peculiarities in calculation ...
Thin film solar cells and solar cell testing - photovoltaic cells, radiation damage to cadmium sulfide solar cells, and airplane testing of solar cells
Decay heat removal capability under boiling condition was studied using an LMFBR fuel subassembly mockup loop. The sodium flow was driven by natural convection through the loop in which was installed a 37-pin bundle heated electrically over a length of 45 cm. The heat flux furnished by the pins was increased stepwise, upon which the two-phase flow regime changed from bubble to slug flow and then to annular or annular mist flow. Dryout occurred even in slug flow regime, but only momentarily, and permanent dryout was not observed before establichment of annular flow. A suitable criterion for permanent dryout is considered to be 0.5 average exit sodium vapor quality. The results indicated that upon occurrence of sodium boiling, the coolability of fuel subassembly would be maintained by natural convection after reactor shutdown. (author).
Water flow experiments were conducted on natural circulation decay heat removal with an electrically heated 91-rod bundle. Experimental results were compared with analytical predictions to provide thermal hydraulic characteristics for LMFBR Fuel assemblies under a low flow, typical of the natural circulation regime. The results revealed that, at low flow rate region (Re<1,200), axial friction loss in a heated bundle increases with buoyancy effect. The radial temperature profile provides some insight regarding the concept that coolant redistribution would occur. COBRA-V-I predictions are successfully proved validity in comparison with experimental results.
Imatran Voima Oy , (IVO) operates two Russian designed nuclear power plants of type VVER440/213. Unit 1 has been operating since 1977 and unit 2 since 1981. First damage of feed water distribution (FWD) pipes was observed in 1989. In closer examinations FWD-pipe T-connection and distribution nozzles suffered from severe erosion corrosion damage. Similar damages have been found also in other VVER-440 type NPPs. In 1994 the first FWD-pipe was replaced by a new design mounted over the tube bundle instead of the old FWD-pipe, which was located inside the tube bundle. The purpose of this paper is to describe the new FWD-pipe and discuss its effects on the steam generator chemistry. (author)
Heat-transfer augmentation by straight grid spacers in rod bundles is studied for single-phase flow and for post-critical heat flux dispersed flow. The heat transfer effect of swirling grid spacers in single-phase flow is also examined. Governing heat-transfer mechanisms are analyzed, and predictive formulations are established. For single-phase flow, the local heat transfer at a straight spacer and at its upstream or downstream locations are treated separately. The effect of local velocity increasing near swirling spacer is considered. For post critical heat flux (CHF) dispersed flow, the heat transfer by thermal radiation, fin cooling, and vapor convection near the spacer are calculated. The predictions are compared with experimental data with satisfactory agreement.
This paper reports that fluidelastic instability is the most important vibration excitation mechanism for heat exchanger tube bundles subjected to cross-flow. Most of the available data on this topic have been reviewed from the perspective of the designer. Uniform definitions of critical flow velocity for instability, damping, natural frequency and hydrodynamic mass were used. Nearly 300 data points were assembled. The authors found that only data from experiments where all tubes are free to vibrate are valid form a design point of view. In liquids, fluid damping is important and should be considered in the formulation of fluidelastic instability. From a practical design point of view, we conclude that fluidelastic instability may be expressed simply in term of dimensionless flow velocity and dimensionless mass-damping. There is no advantage in considering more sophisticated models at this time. Practical design guidelines are discussed.
Abstract The term -stem cell- most commonly refers to embryonic stem cells, particularly in the lay media; however, it also describes other cell types. A stem cell represents a cell of multi-lineage potential with the ability for self-renewal. It is now clear that the plasticity and immortality of a given stem cell will depend on what type of stem cell it is, whether an embryonic stem cell, a fetal-placental stem cell or an adult stem cell. Stem cells offer great promise as cell-based therapies for the future. With evolving technology, much of the socio-political debate regarding stem cells can now be avoided.
Local communities in southern Africa derive many benefits from marula [Sclerocarya birrea (A. Rich.) Hochst. subsp. caffra (Sond.) Kokwaro]. These include the contribution of this species towards health, nutrition, food security and conservation by sharing local skills and knowledge related to it. Marula fruits can be eaten fresh, squeezed to make juice, brewed in traditional beer or used to make jam and jelly. The kernels are also edible and can be pressed to extract oil for cooking and cosmetics, i.e., for skin and hair application. The bark, roots, seeds and leaves are exploited for traditional medicinal purposes. Marula has acquired significant commercial value since its fruits and other products have entered local, regional and international trade in southern Africa. To diversify frui...
In recent years, slightly acid formulas for cosmetics which remove follicular infundibulum obstruction of the hair follicle, have been devised. Therefore, few acne patients experience a problem with cosmetics use. On the other hand, cosmetics use differs from person to person. Thus, an investigation of actual conditions of cosmetics use was done among acne patients. Compared with healthy people, acne patients used more facial wash products more. It has been understood that treatment and skincare instruction are important for the improvement and prevention of acne. We examined skin physiology function and patient's QOL by using a skin care product for women for two months with skincare instruction from a dermatologist for 31 female patients this time. As a result, it was able to be confirme...
Introduction Postoperative alopecia is a relatively rare event, and therefore both patients and surgeons are puzzled once it develops even though it is said to improve spontaneously with time in most cases. We report a parieto-occipital pressure-induced alopecia firstly developed in a patient who had undergone repeated surgery for 10?years after a traffic accident. Case report A 29-year-old male underwent segmental osteotomy at the upper and lower frontal edentulous areas for distraction osteogenesis. Throughout the operation, he was in the supine position with the hair covered with a paper cap and the head on a plastic vinyl chloride-covered soft foam horseshoe-shaped urethane sponge placed on the horseshoe-shaped headrest. About 2?weeks after the surgery, two patches of parieto-occipital...
Transients induced in nuclear power plants from many sources result in one or more fluid conditions changing with time. Fluid conditions of pressure, inlet temperature, inlet flow, or even system power many change separately or in conjunction with each other. The result of the condition change may be one which induces departure from nucleate boiling. An experimental investigation of transient which were intended to achieve Critical Heat Flux was performed at the Heat Transfer Research Facility of Columbia University for Siemens Nuclear Power Corporation. The transients were set up to include broad ranges of flow and pressure conditions near the operating range of pressurized water reactors. Transient events were dominated by varying single conditions and measuring the response of the system and of the rod thermocouples. Because of coupling effects within the test loop, secondary conditions would also vary. In order to perform controlled tests which achieved the desired result, CHF ...
An advanced experimental technique has been developed to simulate two-phase flow behavior in a light water reactor (LWR). The technique applies three kinds of methods; (1) use of sulfur-hexafluoride (SF6) gas and ethanol (C2H5OH) liquid at atmospheric temperature and a pressure less than 1.0MPa, where the fluid properties are similar to steam-water ones in the LWR, (2) generation of bubble with a sintering tube, which simulates bubble generation on heated surface in the LWR, (3) measurement of detailed bubble distribution data with a bi-optical probe (BOP), (4) and measurement of liquid velocities with the tracer liquid. This experimental technique provides easy visualization of flows by using a large scale experimental apparatus, which gives three-dimensional flows, and measurement of detailed spatial distributions of two-phase flow. With this technique, we have carried out experiments simulating two-phase flow behavior in a single-channel geometry, a ...
Silicone-rubber washers function as damping and articulating elements in cast-aluminum spacers that separate bundle subconductors in each phase of extra-high-voltage transmission lines. Spacer/dampers are located every 3 ft. along transmission lines on Canada's first operational 500 and 735 kV system.
One of the limiting contributors to the heat load constraint for the Yucca Mountain repository is the decay of Americium 241. A possible option to reduce the heat load produced by Am-241 is to eliminate or transmute it in a light water reactor thermal neutron environment, particularly, by taking advantage of the thermal fission cross section of Am-242 and Am-242m. In this study we employ lattice loading optimization techniques to define the americium/uranium blending and pin arrangements via an adaptation of the code FORMOSA-L to include the incineration of preloaded americium as an objective function. The optimization routines were designed to maximize americium transmutation, while maintaining power peaking below a predefined constraint. The viability of these lattice designs has been analyzed by creating bundles with these Am-spiked lattices and by loading these bundles into realistic 3D BWR core-wide simulation models over multiple reload ...
The hierarchy of integrable nonlinear equations associated with the quadratic bundle is considered. The expressions for the solution of linearization of these equations and their conservation law in the terms of solutions of corresponding Lax pairs are found. It is shown for the first member of the hierarchy that the conservation law is connected with the solution of linearized equation due to the Noether's theorem. The local hierarchy and three nonlocal ones of the infinitesimal symmetries and conservation laws explicitly expressed through the variables of the nonlinear equations are derived. (author)
This book presents the papers given at a conference on two-phase flow. Topics considered at the conference included the thermal hydraulics of a feedwater pipe breakage, pressure losses, measurement of void fraction in a rod bundle, laminar filmwise condensation, natural circulation, flow models, bubble dynamics, cavitation, water hammer, and heat transfer augmentation.
This book presents the papers given at a conference on two-phase flow. Topics considered at the conference included the thermal hydraulics of a feedwater pipe breakage, pressure losses, measurement of void fraction in a rod bundle, laminar filmwise condensation, natural circulation, flow models, bubble dynamics, cavitation, water hammer, and heat transfer augmentation.
Flow-induced vibration is an important concern to the designers of heat exchangers subjected to high flows of gases or liquids. Two-phase cross-flow occurs in industrial heat exchangers, such as nuclear steam generators, condensers, and boilers, etc. Under certain flow regimes and fluid velocities, the fluid forces result in tube vibration and damage due to fretting and fatigue. Prediction of these forces requires an understanding of the flow regimes found in heat exchanger tube bundles. Excessive vibrations under normal operating conditions can lead to tube failure. Relatively little information exists on two-phase vibration. This is not surprising as single-phase flow induced vibration; a simpler topic is not yet fully understood. Vibration in two-phase is much more complex because it depends upon two-phase flow regime, i.e. characteristics of two-phase mixture and involves an important consideration, which is the void fraction. The effect of characteristics of ...
Human bone marrow mesenchymal stem cells (BM-MSC) are multipotent progenitor cells that have transient immunomodulatory properties on Natural Killer (NK) cells, Dendritic Cells (DC), and T cells. This...Full Text Available
Motivation: Automatic recognition of cell identities is critical for quantitative measurement, targeting and manipulation of cells of model animals at single-cell resolution. It has been...Full Text Available
In order to practice a design-by-analysis of thermohydraulics design of BWR fuel rod bundles, the subchannel analysis would play a major role. There, the immediate concern is improvement in its predictive capability of CHF due in particular to the film dryout (boiling transition phenomena: BT) on the fuel rod surface. Constitutive equations in the subchannel analysis formulation are responsible for the quality of calculated results. The constitutive equations are a result of integration of the local and instantaneous description of two-phase flows over the subchannel control volume. In general, they are expressed in terms of subchannel-control-volume- as well as area-averaged two-phase flow state variables. In principle the information on local and instantaneous physical phenomena taking place inside subchannels must be counted for in the algebraic form of the equations on the basis of a more mechanistic modeling approach. They should include also influences of the ...
Full text of publication follows:In order to practice a design-by-analysis of thermohydraulics design of BWR fuel rod bundles, the subchannel analysis would play a major role. There, the immediate concern is improvement in its predictive capability of CHF due in particular to the film dryout (boiling transition phenomena: BT) on the fuel rod surface. Constitutive equations in the subchannel analysis formulation are responsible for the quality of calculated results. The constitutive equations are a result of integration of the local and instantaneous description of two-phase flows over the subchannel control volume. In general, they are expressed in terms of subchannel-control-volume- as well as area-averaged two-phase flow state variables. In principle the information on local and instantaneous physical phenomena taking place inside subchannels must be counted for in the algebraic form of the equations on the basis of a more mechanistic modeling approach. They ...
In order to practice a design-by-analysis of thermohydraulics design of BWR fuel rod bundles, the subchannel analysis would play a major role. There, the immediate concern is improvement in its predictive capability of CHF due in particular to the film dryout (boiling transition phenomena: BT) on the fuel rod surface. Constitutive equations in the subchannel analysis formulation are responsible for the quality of calculated results. The constitutive equations are a result of integration of the local and instantaneous description of two-phase flows over the subchannel control volume. In general, they are expressed in terms of subchannel-control-volume- as well as area-averaged two-phase flow state variables. In principle the information on local and instantaneous physical phenomena taking place inside subchannels must be counted for in the algebraic form of the equations on the basis of a more mechanistic modeling approach. They should include also influences of the ...
We studied telomeric DNA in leukemic cells as well as in normal T cells, B cells, monocytes, polymorphonuclear leukocytes, and bone marrow hematopoietic progenitor cells. No marked differences were...Full Text Available
An interfacial shear stress equation in the dispersed-annular two-phase flow regime has been developed, which is based on a three-fluid model consisting of a liquid film on a rod, vapor and entrained liquid associated with a vapor flow. It is an extension of J.G.M. Andersen's procedure that provides a two-fluid interfacial shear stress equation using the drift flux parameters C{sub 0} and V{sub gj}. This interfacial shear stress equation can take into account a phase and velocity distribution through an equivalence between the drift flux parameters and the interfacial shear stress. Using the three-fluid subchannel analysis code TEMPO with the three-fluid interfacial shear stress model the capability of a three-fluid calculation using the drift flux parameters C{sub 0} and V{sub gj} that reproduce a measured void fraction is demonstrated. A comparison was made with advanced X-ray computed tomography (CT) void fraction data within a 4x4 rod bundle in ...
A series of 22 steady-state, rod bundle, dispersed flow film boiling experiments has been performed in the Thermal-Hydraulic Test Facility (THTF), a pressurized-water loop containing 64 full-length electrically heated rods. Test parameters in the upflow experiments cover a wide range of conditions typical of those which might be encountered during a nuclear reactor loss-of-coolant accident. Local equilibrium fluid conditions were calculated using mass and energy conservation considerations. Experimentally determined heat transfer coefficients were compared to several available film boiling heat transfer correlations: Dougall-Rohsenow, Groeneveld 5.7, Groeneveld-Delorme, Chen, Jones-Zuber, and Yoder-Rohsenow. The Groeneveld 5.7 correlation tended to predict the data better than any other correlation tested. The Dougall-Rohsenow correlation tends to overpredict the data while the Yoder-Rohsenow correlation predicted the data better than the other nonequilibrium ...
We consider the (2, 0) supersymmetric theory of tensor multiplets and self-dual strings in six space-time dimensions. Space-time diffeomorphisms that leave the string world-sheet invariant appear as gauge transformations on the normal bundle of the world-sheet. The naive invariance of the model under such transformations is however explicitly broken by anomalies: The electromagnetic coupling of the string to the two-form gauge field of the tensor multiplet suffers from a classical anomaly, and there is also a one-loop quantum anomaly from the chiral fermions on the string world-sheet. Both of these contributions are proportional to the Euler class of the normal bundle of the string world-sheet, and consistency of the model requires that they cancel. This imposes strong constraints on possible models, which are found to obey an ADE-classification. We then consider the decoupled world-sheet theory that describes low-energy fluctuations (compared ...
This study describes the mechanical compatibility of the direct use of spent pressurized water reactor (PWR) fuel in Canada deuterium uranium (CANDU) reactors (DUPIC) fuel, when it is loaded into a CANDU reactor. The mechanical compatibility can be assessed for the fuel management, primary heat transport system, fuel channel, and the fuel handling system in the reactor core by both the experimental and analytic methods. Because the physical dimensions of the DUPIC fuel bundle adopt the CANDU flexible (CANFLEX) fuel bundle design which has already been demonstrated for a commercial use in CANDU reactors, the experimental compatibility analyses focused on the generation of material property data and the irradiation tests of the DUPIC fuel, which are used for the computational analysis. The intermediate results of the mechanical compatibility analysis have shown that the integrity of the DUPIC fuel is mostly maintained under the high power and ...
To resolve the central thermal safety issue for spent fuel dry storage concrete canister design or Wolsung (CANDU) nuclear power plant unit 1, a thermal analysis method has been developed for the complicated geometry of rod bundles and the multi-dimensional and multi-mode heat transfer phenomena. The canister geometry is simplified and combined heat transfer by conduction, convection, and radiation is considered through effective heat transfer coefficients. Mean temperature distributions of the fuel bundles within the fuel basket are obtained by solving the heat transfer problem using an existing computer code HEATING5. The measured steady state temperature distribution within a mock-up of a storage basket is compared to the calculated result. Steady state and/or transient fuel temperature distributions have been calculated for various ambient conditions at the canister exterior surface.
To resolve the central thermal safety issue for spent fuel dry storage concrete canister design or Wolsung (CANDU) nuclear power plant unit 1, a thermal analysis method has been developed for the complicated geometry of rod bundles and the multi-dimensional and multi-mode heat transfer phenomena. The canister geometry is simplified and combined heat transfer by conduction, convection, and radiation is considered through effective heat transfer coefficients. Mean temperature distributions of the fuel bundles within the fuel basket are obtained by solving the heat transfer problem using an existing computer code HEATING5. The measured steady state temperature distribution within a mock-up of a storage basket is compared to the calculated result. Steady state and/or transient fuel temperature distributions have been calculated for various ambient conditions at the canister exterior surface.
A novel method to detect and correct inaccuracies in a set of unconstrained dense correspondences between two images is presented. Starting with a robust, general-purpose dense correspondence algorithm, an initial pose estimate and dense 3D scene reconstruction are obtained and bundle-adjusted. Reprojection errors are then computed for each correspondence pair, which is used as a metric to distinguish high and low-error correspondences. An affine neighborhood-based coarse-to-fine iterative search algorithm is then applied only on the high-error correspondences to correct their positions. Such an error detection and correction mechanism is novel for unconstrained dense correspondences, for example not obtained through epipolar geometry-based guided matching. Results indicate that correspondences in regions with issues such as occlusions, repetitive patterns and moving objects can be identified and corrected, such that a more accurate set of dense correspondences ...
It is one of the most important subjects to estimate the flow-related stability of the heat exchanger tubes. A large scale model steam generator has been developed to verify the stability of the tubes in the Japanese PWR steam generators for the two-phase flow-induced vibration and to accumulate related technical data of thermal-hydraulic and flow-induced vibration of U-bend tube bundle. The model steam generator has 230 U-bend tubes of 46 different radius and 5 columns for each of practical diameter and material, and the anti vibration bars are inserted into each spacing between tube arrays. The freon R123 has been used as the secondary side fluid in stead of water-steam two-phase. In the test, void fraction and interfacial velocities in U-bend and straight tube-bundle are measured with bi-optical probes, and vibration responses of some selected tubes are measured with strain gauges and accelerators. It is verified that the U-bend tubes are ...
The presentation summarises the highlights of experimental results obtained for VVER type horizontal steam generator heat transfer, primary side flow pattern, and mixing in the hot collector during secondary side boil-off with primary at single-phase natural circulation. The experiments were performed using the PACTEL facility with Large Diameter (LD) steam generator models, with collector instrumentation designed specifically for these tests. The key findings are as follows: (1) the primary to secondary heat transfer degrades as the secondary water inventory is depleted, following closely the wetted tube area; (2) a circulatory flow pattern exists in the tube bundle, resulting in reversed flow (from cold to the hot collector) in the lower part of the tube bundle, and continuous flow through the upper part, including the tubes that have already dried out; and (3) mixing of the hot leg flow entering the hot collector and reversed, cold, tube ...
The MACSTOR/KN-400 of Wolsung power plant in Korea is a dry interim storage facilities. There are 400 long slender cylinders in MACSTOR/KN-400. In one cylinder, ten baskets where Candu spent fuels are loaded are stacked and stored. For this MACSTOR/KN-400 facilities, analyses and tests for the hypothetical accident conditions that might happen during moving and storing baskets into a cylinder were performed. The hypothetical accident conditions to be considered are two cases. One is the case of basket dropping onto the bottom plate of a cylinder. The other is the case of basket dropping onto the other basket top plate stored in the cylinder. For the drop analyses, the case of hanging cylinder and the case of cylinder on the unyielding target surface were considered. Based on the dropping analysis, testing condition was determined as the latter case that is for the cylinder on the target surface. In a basket, 60 dummy fuel bundles are loaded which have the same ...
A mathematical model is described for determining the level profile along the length of heat exchange tubes in a horizontal steam generator, and for determining the conditions in the steam cushion under the perforated sheet. The water level area is divided in the model into 36 partial elements; for analysis of the conditions under the level, the steam-water space is divided into four areas. The results of the calculations were compared with measurement results for the steam generator rated values. Very good agreement was found. The results show that, among others, the supply water distribution very much affects the conditions in the area of the steam cushion and of the bubble vacuum. Also, the average steam load of the inner bundle tubes is significantly higher than that of the outer bundles. It was also shown that permanent steam generator operation with exposed top tube rows may occur even in some permissible operating conditions. This is ...
The CANFLEX-NU Fuel Design Report (FDR) for Wolsung 1,2,3,4 was submitted for licensing review in July 1996. The FDR contains sections of fuel rod design, fuel bundle design, nuclear design and thermal-hydraulic design. Each section describes the design bases, design methodology and design evaluation results showing that the design bases are met. The CANFLEX-NU fuel design is not finalized yet in Korean licensing point of view. For example, among others, new Xc-BL correlation is needed to be developed, fuel rod gap reduction effect is to be considered in the Critical Heat Flux, more information for power ramp defect of fuel rod especially in the end-cap weld region is needed in the fuel rod design, and enough data are not available in irradiated conditions in the fuel rod and bundle designs. The specific detailed technical licensing issues and their backgrounds are explained for the CANFLEX-NU FDR in Korea. The Korean nuclear regulation ...
The Department of Nuclear Engineering and Fluid Mechanics in the University of the Basque Country (UPV-EHU), has done calculations for the proposed benchmark problem, in the frame of the 11th international meeting of the IAHR working group on advanced nuclear reactors thermal-hydraulics (Obninsk-Russian Federation, 5-9 July 2004). The purpose of the benchmark is to compare experimental and analytical results of some experiments carried out in the State Scientific Center of Russian Federation 'Institute of Physics and Power Engineering' (SSC RF IPPE). These experiments were held to research the cooling of pin bundles by liquid metals in reference to the core of Nuclear Reactors such as BREST. The analytical results have been done with the Computational Fluid Dynamics (CFD) code FLUENT. Temperature and velocity fields are the main variables considered for the comparison, and some assumptions has been made in order to simplify a complicate geometry with grids and ...
The objective of this report was to evaluate four possible alternative methods of preparing and packaging spent fuel assemblies for geologic disposal against the Reference Process of unmodified spent fuel. The four alternative processes were: (1) End fitting removal, (2) Fission gas venting and resealing, (3) Fuel bundle disassembly and close packing of fuel pins, and (4) Fuel shearing and immobilization. Systems analysis was used to develop a basis of comparison of the alternatives. Conceptual processes and facility layouts were devised for each of the alternatives, based on technology deemed feasible for the purpose. Assessments were made of 15 principal attributes from the technical, operational, safety/risk, and economic considerations related to each of the alternatives, including both the surface packaging and underground repository operations. Specific attributes of the alternative processes were evaluated by assigning a number for each that expressed its ...
Experimental and computational studies were performed to confirm the enhancement of turbulent heat transfer performance in the 6x6 simulated rod bundle subchannel by generating the large scale secondary vortex flow. Experimental studies were carried out at Reynolds Number 10,000 with atmospheric condition. Axial variations of mean velocity and turbulent intensity in the rod bundle subchannel were measured by the 2-color LDV measurement system. Computational works were accomplished using the commercial CFD code, FLUENT. Normal operating condition of Uljin 3, 4 nuclear power plant is used in computation works as an initial condition. The LSSVF mixing vanes generate the most strong secondary flow vortices that maintain about 35 D_H after the spacer grid. The LSSVF mixing vane influences strongly to flow mixing in adjacent subchannels because large scale stream wise vortices in subchannel sustain two times more than that in subchannel with split ...
A simplified two step thermal analysis method has been develop to evaluate (1) the mean temperature of the CANDU fuel bundles within a fuel basket in a given spent fuel dry storage canister by HEATING5 code with additional input data and heat transfer correlations in the step-1 analysis and (2) the maximum fuel rod temperature within a CANDU 37-element fuel bundle by MAXROT code developed here for step-2 analysis. In addition, the results of sample analysis is performed to examine the parametric effects of the site-specific ambient conditions on the maximum fuel temperature within a canister are presented. The comparison between the results of step-1 analysis and the mock-up test, in particular, is quite satisfactory. In essence, the two-step thermal analysis method proposed here is a code package that used the HEATING5 and MAXROT codes, respectively, for step-1 and step-2 calculations in series.
A simplified two step thermal analysis method has been develop to evaluate (1) the mean temperature of the CANDU fuel bundles within a fuel basket in a given spent fuel dry storage canister by HEATING5 code with additional input data and heat transfer correlations in the step-1 analysis and (2) the maximum fuel rod temperature within a CANDU 37-element fuel bundle by MAXROT code developed here for step-2 analysis. In addition, the results of sample analysis is performed to examine the parametric effects of the site-specific ambient conditions on the maximum fuel temperature within a canister are presented. The comparison between the results of step-1 analysis and the mock-up test, in particular, is quite satisfactory. In essence, the two-step thermal analysis method proposed here is a code package that used the HEATING5 and MAXROT codes, respectively, for step-1 and step-2 calculations in series.
The effect of heat transfer is described from heat exchange tubes of a horizontal steam generator on the distribution of primary water to the individual tubes of the tube bundle. It is shown that in a broad interval of mass flow rates and lengths of heat exchange tubes, the simplified method of calcualtion, i.e., calculation of the distribution of primary water into heat exchange tubes neqlecting the changes of physical properties of water along the heat exchange tubes, will yield sufficiently accurate results.
The effect of heat transfer is described from heat exchange tubes of a horizontal steam generator on the distribution of primary water to the individual tubes of the tube bundle. It is shown that in a broad interval of mass flow rates and lengths of heat exchange tubes, the simplified method of calcualtion, i.e., calculation of the distribution of primary water into heat exchange tubes neqlecting the changes of physical properties of water along the heat exchange tubes, will yield sufficiently accurate results. (author).
Audible noise from corona discharge had been identified as one of the most important factors in the design of conductor configurations for high-voltage transmission lines. 500 kV and above. Therefore this paper describes audible noise characteristics of 6 X 480 mm{sup 2} conductor bundle in KEPRI 765 kV Test Line and Corona Cage. Prediction formula for audible(corona) noise on a 765 kV Transmission Line was developed using this results. (author). 4 refs., 4 figs., 4 tabs.
Tube failures due to excessive flow-induced vibration must be avoided to assure the reliable performance of heat exchangers. Such components must be thoroughly analysed for vibration at the design stage. Several flow-induced vibration mechanisms are possible. In this paper, particular attention is given to fluidelastic instability of tube bundles subjected to liquid and two-phase cross-flow. The performance of ten operating heat exchanger components is reviewed to validate our recommended vibration analysis guidelines. Both tube failure histories and satisfactory performances are considered. The results show that a fluidelastic instability constant K=3.3 is a reasonable design criterion. (auth).
Since January, 1981, the project of development of nuclear fuel fabrication technology for Wolsung reactor (CANDU type) was undertaken by KAERI(Korea Advanced Energy Research Institute) and successfully fulfilled with loading 24 fuel bundles made by KAERI in Wolsung reactor in September, 1984. On the basis of this accumulated technology and experience, mass production plan to supply all the nuclear fuels for Wolsung reactor is under way. In this presentation, the Korean experience in the development of the nuclear fuel fabrication technology, safety and performance evaluation of KAERI fuel and the results of irradiation of KAERI fuels in Wolsung reactor will be described.
Since January, 1981, the project of development of nuclear fuel fabrication technology for Wolsung reactor (CANDU type) was undertaken by KAERI(Korea Advanced Energy Research Institute) and successfully fulfilled with loading 24 fuel bundles made by KAERI in Wolsung reactor in September, 1984. On the basis of this accumulated technology and experience, mass production plan to supply all the nuclear fuels for Wolsung reactor is under way. In this presentation, the Korean experience in the development of the nuclear fuel fabrication technology, safety and performance evaluation of KAERI fuel and the results of irradiation of KAERI fuels in Wolsung reactor will be described.
Multi-dimensional modelling of two-phase flow requires accurate constitutive relationships for interfacial parameters such as interfacial heat transfer, void fraction distribution, interfacial area, etc. However, existing diagnostic systems for measurement of two-phase flow parameters have difficulty measuring two or three-dimensional void distributions required for determination of interfacial parameters. In this work, a Real-Time Neutron Radiography (RTNR) system is developed for non-intrusive measurement of two-phase flow parameters in nuclear fuel channels at low thermal neutron fluxes (on the order of 10{sup 6}n/cm{sup 2}-s). This advanced radiation technique has the advantage of measuring two-phase flow in 3 1/2 dimensions (x,{integral}dy,t) where the 1/2 dimension refers to an integrated or averaged space dimension. Pipe flow channels, annulus flow channels, MAPLE-type nuclear fuel flow channels, and CANDU-type nuclear fuel flow channels are investigated. Measurements of flow ...
Multi-dimensional modelling of two-phase flow requires accurate constitutive relationships for interfacial parameters such as interfacial heat transfer, void fraction distribution, interfacial area, etc. However, existing diagnostic systems for measurement of two-phase flow parameters have difficulty measuring two or three-dimensional void distributions required for determination of interfacial parameters. In this work, a Real-Time Neutron Radiography (RTNR) system is developed for non-intrusive measurement of two-phase flow parameters in nuclear fuel channels at low thermal neutron fluxes (on the order of 10"6n/cm"2-s). This advanced radiation technique has the advantage of measuring two-phase flow in 3 1/2 dimensions (x,#integral#dy,t) where the 1/2 dimension refers to an integrated or averaged space dimension. Pipe flow channels, annulus flow channels, MAPLE-type nuclear fuel flow channels, and CANDU-type nuclear fuel flow channels are investigated. Measurements of flow regime, void ...
The main purpose of this paper is to stress the importance of CT depiction of the mandibular incisive canal. This anatomical structure contains a major neurovascular bundle and is thus very important in the planning of mandibular implants in the canine-incisive area. The importance of careful assessment of the mandibular canal course before implantology is now widely recognized. The same holds true for the canine-incisive region in the jaw, to detect the incisive canal if present and prevent any complications from its accidental damage. CT with a dedicated software showed the incisive canal in a large number of patients, which calls for precise reporting of its presence, course, and relationships with teeth.
SnO{sub 2}-carbon nanotube (CNT) composite sheets are synthesized using poly(vinylpyrrolidone) to uniformly load a monolayer of SnO{sub 2} nanoparticles onto the surfaces of CNTs and CNT bundles within cross-stacked CNT sheets. When they are used as high-capacity (over 850 mA h g{sup -1}) and binder-free anodes in rechargeable lithium-ion batteries, they exhibit good cycle performance. (Abstract Copyright [2009], Wiley Periodicals, Inc.)
It has been issued that ROP(Regional Overpower Protection) for Wolsong Unit 1 needed to be reanalyzed due to the aging effect. Thermo-hydraulics and core simulation have to be performed for calculation of the fuel bundle power, channel power and detector signal production. PPV/MULTICELL/RFSP code system was used to calculate the power distribution for the ROP analysis. In this study, 232 cases out of 926 scenarios which include postulated accidents such as Startup after Short Shutdown, Shim Cases, Stepback, Insertion and Withdrawal of Reactivity Control Rods were simulated.
From the start of commercial operation in 1983 until the end of 1985, the Wolsung Nuclear Power Plant operated for about 800 effective full power days (EFPDs). During this relatively short operational period it experienced various problems but achieved high reliability in operation. Wolsung recorded economical fuel utilization, particularly in 1985, together with a 94.4% plant capacity factor; it also showed successful in-pile test results as part of a fuel localization project. The actual fuelling rate was 16.3 bundles per EFPD in 1985, i.e. a saving of about 11% compared with the design fuelling rate of 18.2 bundles per EFPD. Better fuel performance was achieved because minimum excess reactivity was maintained in the core, characteristics unique to the core were found and the spatial flux distribution was controlled. The average discharge fuel burnup in 1985 was 6993 MW#centre dot#d/t U, which was 8.5% more than the design value of 6446 ...
In order to practice design-by-analysis of thermohydraulics design of BWR fuel rod bundles, the subchannel analysis would play a major role. There, one of the immediate concerns is improvement in its predictive capability of boiling transition phenomena on the fuel rod surface. This capability strongly depends on the modeling of thermohydraulics phenomena of interests: 1) vapor-liquid redistribution by inter-subchannel exchanges due to the diversion cross flow, turbulent mixing and void drift, 2) liquid film behaviors, 3) transition of two-phase flow regimes, 4) droplet entrainment and deposition and 5) spacer-droplet interactions. These are considered to be five key factors in understanding the BT in BWR fuel rod bundles. This paper describes a progress and current status in the second year of the three year project on developing generalized boiling transition models with the above five key factors being focused on. A combined approach of ...
As a part of the compatibility analysis of DUPIC fuel in CANDU reactors, the radiation physics calculations have been performed for the CANDU primary shielding system, thermal shield, radiation damage, transportation cask and storage. At first, the primary shield system was assessed for the DUPIC fuel core, which has shown that the dose rates and heat deposition rates through the primary shield of the DUPIC fuel core are not much different from those of natural uranium core because the power levels on the core periphery are similar for both cores. Secondly, the radiation effects on the critical components and the themal shields were assessed when the DUPIC fuel is loaded in CANDU reactors. Compared with the displacement per atom (DPA) of the critical component for natural uranium core, that for the DUPIC fuel core was increased by -30% for the innermost groove and the weld points and by -10% for the corner of the calandria subshells and annular plates in the calandria, respectivdely. ...
This RD&D project is a three year team effort to develop a hybrid solar lighting (HSL) system that transports daylight from a paraboloidal dish concentrator to a luminaire via a bundle of small core or a large core polymer fiber optics. The luminaire can be a device to distribute sunlight into a space for the production of algae or it can be a device that is a combination of daylighting and electric lighting for space/task lighting. In this project, the sunlight is collected using a one-meter paraboloidal concentrator dish with two-axis tracking. For the second generation (alpha) system, the secondary mirror is an ellipsoidal mirror that directs the visible light into a bundle of small-core fibers. The IR spectrum is filtered out to minimize unnecessary heating at the fiber entrance region. This report describes the following investigations of various aspects of the system. Taken as a whole, they confirm significant progress towards the ...
Sulfur dioxide emissions from an iron ore sintering plant have severely damaged vegetation up to 16 km northeast of the source. Concentric zones of increasing vegetation loss have formed around the point of maximum ground level concentration of the gas. Species diversity, sulfur and heavy metal concentrations in vegetation and soil amount to SO/sub 2/ injury were measured along a transect through the injury zones. Surrounding a central denuded area were zones dominated respectively by tussock-forming hair grass (Deschampsia flexuosa); low-growing shrubs and trailers (Sambucus pubens, Polygonum cilinode); higher-growing shrubs and suckering Populus tremuloides and Betula papyrifera) stunted forest tree species (Populus, Betula, Picea glauca, Abies Balsamea), and finally, normal boreal forest flora. Although SO/sub 2/ injury is continuing in this area, these zones now appear to be maintained primarily by severe erosion and destruction of suitable habitats for ...
Comprehensive investigation has been made into the application of the polymerization hardening by radiation, particularly electron beam, to the composites of polymers and other materials. The report is divided into four parts, namely 1) characteristics and problems of the reaction of curing by radiation polymerization, 2) improvement of the bonding capability of high molecular weight materials, 3) bonding by radiation, and 4) composites made by the impregnation and polymerization hardening of monomers. The first part includes the effects of dose rate, temperature rise during the hardening, the peculiarity of electron beam irradiation at high dose rate, reaction environment and additive effects. Main conclusions are as follows: caution must be taken to the amount of residual double bonds because they affect the quality of hardened polymers; the polymerization hardening reaction at high dose rate cannot be analogized by that at low dose rate; and the presence of the inhibitors of radical ...
We have investigated the properties of nerve cell precursors in hydra by analyzing the differentiation and proliferation capacity of interstitial cells in the peduncle of Hydra oligactis, which is a region of active nerve cell differentiation. Our results indicate that about 50% of the interstitial cells in the peduncle can grow rapidly and also give rise to nematocyte precursors when transplanted into a gastric environment. If these cells were committed nerve cell precursors, one would not expect them to differentiate into nematocytes nor to proliferate apparently without limit. Therefore we conclude that cycling interstitial cells in peduncles are not intermediates in the nerve cell differentiation pathway but are stem cells. The remaining interstitial cells in the peduncle are ...
A silicon solar cell assembly comprising a large, thin silicon solar cell bonded to a metal mount for use when there exists a mismatch in the thermal expansivities of the device and the mount.
Experiments were designed to elucidate whether or not the irradiated bone marrow cells receive any stimulation for the self-replication and differentiation from normal 'stromal' cell colonies in the bone marrow cell culture in vitro. When irradiated or unirradiated bone marrow cells were overlaid on the normal adherent cell colonies, the proliferation of haemopoietic stem cells was supported, the degree of the stimulation depending on the starting cellular concentration. There was, however, no significant changes in the concentration of either CFUs or CFUc regardless of the dose of irradiation on the bone marrow cells overlaid. This was a great contrast to the dose-dependent decrease of CFUs or CFUc within the culture in which both the stem cells and stromal cells were ...
Ethane oxidation was studied in ethane-grown resting cells (mycelia) of an Acremonium sp. and in cell-free preparations of such mycelia. From resting cell experiments evidence was found for a pathway...Full Text Available
In most adult tissues there reside pools of stem and progenitor cells inside specialized microenvironments referred to as niches. The niche protects the stem cells from inappropriate expansion...Full Text Available
... Fuel Cell Technologies Equipment on Environmental Expert Find and compare a variety of fuel cell technologies equipment on the world's largest environmental industry portal. View ...
Purpose.There is a paucity of neuron replacement studies for retinal ganglion cells. Given the complex phenotype of these neurons, replacement of ganglion cells may be impossible....Full Text Available
Cell cultures were prepared from lung tumors occurring in beagles following exposure to inhaled plutonium. Morphologic and growth characteristics of two of these cell lines are described.
We report the isolation of adherent, clonogenic, fibroblast-like cells with osteogenic and adipogenic potential from the blood of four mammalian species. These cells phenotypically resemble but are...Full Text Available
Effects of cell concentrations on the survival and repopulation of haemopoietic stem cells after irradiation were studied in the long-term culture of mouse bone marrow cells in vitro. No difference was observed in the survival of the stem cells among cultures in which 0 - 10/sup 7/ cells were re-inoculated on the adherent cell colonies in the culture flask. Stem cells showed a significant proliferation within 1 week and the number of the stem cells exceeded the control in 3 weeks after irradiation in the cultures with less than 10/sup 6/ re-inoculated cells per flask. In contrast, there was a considerable delay in the onset of stem cell proliferation after irradiation in the culture with 10/sup 7/ cells per flask. Based on these results, a possibility that a ...
SummaryIn vivo tumor cell migration through integrin-dependent pathways is key to the metastatic behavior of malignant cells. Using quantitative in vivo...Full Text Available
Terminal differentiation of many vascular cells involves cell wall changes. Cells first elongate their primary wall, then lay down a lignified secondary wall, which is often followed by digestion of...Full Text Available
For proper tissue morphogenesis, cell divisions and cell fate decisions must be tightly and coordinately regulated. One elegant way to accomplish this is to couple them with asymmetric cell divisions....Full Text Available
Totipotent stem cells have the potential to differentiate into every cell type. Renewal of totipotent stem cells in the germline and cellular differentiation during early embryogenesis rely upon posttranscriptional...Full Text Available
We have established a cartilaginous fish cell line [Squalus acanthias embryo cell line (SAE)], a mesenchymal stem cell line derived from the embryo of an elasmobranch, the spiny dogfish...Full Text Available
AIM: To isolate and identify the biological characteristics of human colon cancer stem cells (SW1116 cells) and further study their proteome.METHODS: SW1116 cells were isolated and cultured with...Full Text Available
Interleukin 2 (IL-2) and B-cell growth factors I and II (BCGF I and BCGF II) are lymphokines produced by T cells that play a major role in T- and B-cell cooperation. Peripheral blood lymphocytes from...Full Text Available
Normal cells, both in vivo and in vitro, become quiescent after serial cell proliferation. During this process, cells can develop immortality with genomic instability,...Full Text Available
BackgroundStem cell characteristics are an important feature of human cancer cells and play a major role in the therapy resistance of tumours. Strategies to target cancer stem cells...Full Text Available
Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known to communicate with one another. Their interactions not only serve to support fully functional blood...Full Text Available
BackgroundAs the resident stem cells of skeletal muscle, satellite cells are activated by extracellular cues associated with local damage. Once activated, satellite cells will re-enter...Full Text Available
Craniofacial injuries require a variety of different cell types to repopulate areas of bone, cartilage, tendon, and fat. Mesenchymal stem cells (MSCs) provide a multipotent cell source for tissue...Full Text Available
We describe the lethal, recessive accelerated-cell-death11 Arabidopsis mutant (acd11). Cell death in acd11 exhibits characteristics of animal apoptosis...Full Text Available
Somatic cell nuclear transfer or therapeutic cloning has provided great hope for stem cell-based therapies. However therapeutic cloning has been experiencing both ethical and technical difficulties....Full Text Available
Background:Stem cells can differentiate into multiple cell types, and therefore can be used for cellular therapies, including tissue repair. However, the participation of stem cells...Full Text Available
It has been postulated that thrombin binds to endothelial cells through, at least in part, cell surface glycosaminoglycans such as heparan sulfate, which could serve as antithrombin cofactor on the...Full Text Available
Hematopoietic stem cells replenish all the cells of the blood throughout the lifetime of an animal. Although thousands of stem cells reside in the bone marrow, only a few contribute to blood production...Full Text Available
In the growing chloronema cell suspension cultures of the moss Funaria hygrometrica Hedw., activities of several enzymes have been found to be cell-density-dependent. Cyclic nucleotide...Full Text Available
In preimplantation mouse development, the first cell lineages to be established are the trophectoderm (TE) and inner cell mass. TE possesses epithelial features, including apical-basal cell polarity...Full Text Available
...false Guidelines for Human Stem Cell Research Presidential Documents ...2009 Guidelines for Human Stem Cell Research Memorandum for the Heads...scientifically worthy human stem cell research, including human...
We have developed a cell-mediated mutagenesis assay in which cells with the appropriate markers for mutagenesis are co-cultivated with either lethally irradiated rodent embryonic cells that can metabolize carcinogenic hydrocarbons or with primary rat liver cells that can metabolize chemicals carcinogenic to the liver. During co-cultivation, the reactive metabolites of the procarcinogen appear to be transmitted to the mutable cells and induce mutations in them. Assays of this type make it possible to demonstrate a relationship between carcinogenic potency of the chemicals and their ability to induce mutations in mammalian cells. In addition, by simultaneously comparing the frequencies of transformation and mutation induced in normal diploid hamster cells by benzo(a)pyrene (BP) and one of its metabolites, it is possible to estimate the genetic ...
...Basic Information | Fuel Cells & Vehicles | US EPA This web page provides basic information on EPA's Fuel Cells & Vehicles web site ...including the chemical composition of fuel cell technology, how it works, descriptions of the various types of fuel cells , their availability and ... background,electrochemical,hydrogen,fuel cell,fuel cell vehicle,fuel reformer,performace,improved fuel economy,increased engine efficiency,lower emissions,zero emissions,availablity,fuel cell types,diagram,Proton ...Exchange Membrane,PEM Basic Information | Fuel Cells & Vehicles | US EPA background,electrochemical,hydrogen,fuel cell,fuel cell vehicle,fuel reformer,performace,improved fuel economy,...
Laser-assisted processing techniques for producing high-quality solar cell metallization patterns are investigated, developed, and characterized. The tasks comprising these investigations are outlined. A new batch of solar cells was processed using the laser decomposition of spun-on silver neodecanoate to metallize cells. Decomposition of silver neodecanoate was carried out at different laser powers on different cells on a given wafer to determine whether this would have any effect on cell performance. Solar cells which were written with laser powers of 5 to 8 watts, gave excellent results with cell efficiencies in the range of 14 to 16%.
... nent to the design and construction of metal-semiconductor solar cells, in that both the photovoltage and the efficiency of metal-semiconductor cells ...
... and pathogen transmission. Because the ultimate object of stem cell research is cell-based clinical therapy, hES cells should ... 4%) Supported by grants (SC12021 and SC11012) from Stem Cell Research...
Abstract Epstein-Barr virus (EBV), which infects not only B cells, but also T cells and natural killer (NK) cells, is associated with multiple lymphoid malignancies. Recently, the proteasome inhibitor bortezomib was reported to induce apoptosis of EBV-transformed B cells. We evaluated the killing effect of this proteasome inhibitor on EBV-associated T lymphoma cells and NK lymphoma cells. First, we found that bortezomib treatment decreased the viability of multiple T and NK cell lines. No significant difference was observed between EBV-positive and EBV-negative cell lines. The decreased viability in response to bortezomib treatment was abrogated by a pan-caspase inhibitor. The induction of apoptosis was confirmed by flow cytometric assessment of annexin V staining. Additionally, cleavage o...
In the past few decades the need for improved nuclear reactor safety analyses has led to a rapid development of advanced methods for multidimensional thermal-hydraulic analyses. These methods have become progressively more complex in order to account for the many physical phenomena anticipated during steady state and transient Light Water Reactor (LWR) conditions. The advanced thermal-hydraulic subchannel code COBRA-TF (Thurgood, M. J. et al., 1983) is used worldwide for best-estimate evaluations of the nuclear reactor safety margins. In the framework of a joint research project between the Pennsylvania State University (PSU) and AREVA NP GmbH, the theoretical models and numerics of COBRA-TF have been improved. Under the name F-COBRA-TF, the code has been subjected to an extensive verification and validation program and has been applied to variety of LWR steady state and transient simulations. To enable F-COBRA-TF for industrial applications, including safety margins evaluations and ...
Infinite loop space theory, both additive and multiplicative, arose largely from two basic motivations. One was to solve calculational questions in geometric topology. The other was to better understand algebraic K-theory. The Adams conjecture is intrinsic to the first motivation, and Quillen's proof of that led directly to his original, calculationally accessible, definition of algebraic K-theory. In turn, the infinite loop understanding of algebraic K-theory feeds back into the calculational questions in geometric topology. For example, use of infinite loop space theory leads to a method for determining the characteristic classes for topological bundles (at odd primes) in terms of the cohomology of finite groups. We explain just a little about how all that works, focusing on the central role played by E infinity ring spaces.
On all steam turbines operating with condensation the air leakage penetrating from the part of the plant which is under vacuum must be eliminated, in order to maintain the vacuum created by physical conditions. In order to attain effective air bleed-off, the water-steam-air mixture is conveyed via the super-cooling bundles in the condenser. In this way the steam partial pressure decreases and the air partial pressure increases at a constant condenser pressure. In this procedure the mixture is supercooled by about 4"0C compared with the saturate steam temperature appertaining to the condenser pressure. The values of volume of air leakage are the result of a year's experience on existing plant. (orig.).
The mature spermatozoon of Cricocephalus albus is filiform, tapered at both ends and shows the following features: 2 axonemes of different lengths presenting the 9+''1'' trepaxonematan pattern, 2 bundles of parallel cortical microtubules, a mitochondrion and a nucleus. Nevertheless, the particularity of the spermatozoon of C. albus is its anterior extremity with an apical electron-dense material associated with extramembranar ornamentation, a cytoplasmic dorsolateral expansion and spine-like bodies. To our knowledge, such an anterior extremity of the spermatozoon has not previously been described from a species of the superfamily Pronocephaloidea. Our study provides new data on the mature gamete of C. albus in order to improve our understanding of the pronocephaloidean phylogenetic relatio...
We study the temporal evolution of coronal loops using data from the Solar X-ray Imager (SXI) on board of GOES-12. This instrument allows us to follow in detail the full lifetime of coronal loops. The observed light curves suggest three somewhat distinct evolutionary phases: rise, main, and decay. The durations and characteristic timescales of these phases are much longer than a cooling time and indicate that the loop-averaged heating rate increases slowly, reaches a maintenance level, and then decreases slowly. This suggests that a single heating mechanism operates for the entire lifetime of the loop. For monolithic loops, the loop-averaged heating rate is the intrinsic energy release rate of the heating mechanism. For loops that are bundles of impulsively heated strands, it is an indication of the frequency of occurrence of individual heating events, or nanoflares. We show that the timescale of the loop-averaged heating rate is proportional to the timescale of ...
The two-fluid model representation for calculations of two-phase flow characteristics in the FBR fuel pin bundles with liquid metal cooling is presented and analysed. Two conservation equations systems of the mass, momentum and energy have been written for each phase. Components accounted the mass-, momentum- and heat transfer throughout the interface occur in the macro-field equations after the averaging procedure realisation. The pattern map and correlations for two-fluid model in vertical liquid metal flows are presented. The description of processes interphase mass- and heat exchange and interphase friction is determined by the two-phase flow regime. The opportunity of the liquid metal two-phase flow regime definition is analysed. (author)
We investigate the relation between the symmetries of a quantum system and its topological quantum numbers, in a general C*-algebraic framework. We prove that, under suitable assumptions on the symmetry algebra, there exists a generalization of the Bloch-Floquet transform which induces a direct-integral decomposition of the algebra of observables. Such generalized transform selects uniquely the set of "continuous sections" in the direct integral, thus yielding a Hilbert bundle. The emerging geometric structure provides some topological invariants of the quantum system. Two running examples provide an Ariadne's thread through the paper. For the sake of completeness, we review two related theorems by von Neumann and Maurin and compare them with our result.
The Superphenix 750-MW (thermal), once-throughtype steam generators are the result of over 10 years of intensive research and development. Detailed design and manufacture of the components lasted from 1977 to 1982. The main difficulties encountered during the construction of these prototype units concerned: demonstration of satisfactory high-temperature properties of Alloy 800 tubes; proven resistance of tube welds to thermal fatigue and of structures and shells to sodium/ water reaction effects; prevention of the tube bundle to flow-induced vibration; necessity of manual welding of shells to prevent hot cracking hazards related to the boron content of the steel; and welding of heat exchange tubes. None of these difficulties, however, invalidated initial major design choices, but provided a wealth of technical and technological experience and knowledge for the steam generators of the future. Plans for the future include revision of the specifications (Alloy 800, in ...
For the determination of the thermal-hydraulic performances of rough surfaces, the method of evaluation is particularly important. In order to increase confidence in the results, a new evaluation procedure was introduced. This procedure is based on the transformation of simple channel experimental results to equal boundary conditions, and on the suitable application and confirmation of these transformed values in more complicated flow channel geometries. Existing methods, applied to the results obtained in an annular channel, do not fulfil all the transformation requirements. Thus a new, more complete transformation method, which uses the turbulent eddy diffusivity model, was developed. To check the quality of this transformation, within the scope of the new evaluation procedure, the results of experimental investigation in annular channels and in a bundle of hexagonal geometry were used together with the predictions of benchmark calculations. The success of the ...
Results of ongoing research project at the McMaster Nuclear Reactor Facility on real-time neutron radiography for the visualization of interfacial geometry, movements and phase distributions in gas-liquid and gas-liquid-metal multi-phase flows are presented. Experiments were conducted with bubble column tubes with boiling liquid nitrogen, air-water and air-mercury mixtures. Discussions are also focused on air-water flowing within a tube containing a CANDU type 37 rod fuel bundle assembly positioned both horizontally and vertically. Computer processing using a digital image format to enhance the real-time images was used. Imaging techniques include frame averaging, background substraction, edge enhancement (spatial filtering), contrast enhancement and video densitometry. (orig.).
Polysomaty analysis of the succulent portulaca (Portulaca grandiflora Hook.) plant was carried out using flow cytometry. For both diploid and tetraploid plants, mature leaf tissue was found to have a higher level of polysomaty than young leaf tissue. Mesophyll (MP), bundle sheath (BSP) and water storage protoplasts (WSP) were isolated from leaf tissues of diploid portulaca plants. WSP had a higher degree of endopolyploidization than MP and BSP. The ploidy distribution was also variable in different floral organs. Tetraploid plants artificially induced by colchicine treatment showed a decline in the degree of polysomaty compared to diploid plants. Tetraploid plants had more spherical leaves, a larger number of petals and lower pollen fertility than diploid plants. PMID:10936528
RODbaffle heat exchanger is a kind of shell-and-tube heat exchanger with eminent performance. Because of the characteristics of tube bundle support structure, fluid flow on shellside is longitudinal and periodical, and fluid flow is of symmetry in landscape orientation. According to the fluid flow characteristics on shellside and ignoring the impact of inlet, outlet and shell wall, a periodic flow unit duct was taken as the simplified model of the shellside to perform numerical simulation by using CFD code, FLUENT. It was found that the both errors in magnitude of the main fluid velocities and heat transfer coefficients between results of simulation and that of experiment or correlations are less than 10%, and the errors of pressure drop between simulation and correlation are no more than 20%. The detailed characteristics and relation of fluid flow and heat transfer on shellside of the RODbaffle heat exchanger were analyzed using the simulation results. (author)
A review of analytical design methods used for predicting reactor core flow and temperature distributions is presented with emphasis on LMFBR's. The paper also briefly describes and contrasts the methods used for LWR's. These methods are global analysis, subchannel analysis, distributed parameter, and hybrid analysis. The evolution of the local and subchannel analysis methods is presented. Data used for code validation are also presented. Current research and development needs are identified and discussed. Areas identified for future research and development include methods and expermental data for analysis of distorted bundles and natural convection. Methods that have been developed for predicting the safety performance of LMFBR's and LWR's are not within the scope of this paper.
The present paper deals with instabilities of long homogeneous and isotropic thin shells, characterized by geometrical non-linearities and imperfections, with reference to a bent helicoidally geometrical shape of particular interest for the helicoidal steam generators tube bundle. Apparently no data exist in the literature to describe the non-linear buckling behaviour of curved thin shells under external pressure, thus, the theoretical analyses based on the classical linear elastic theory, as expected, might be inadequate to evaluate the collapse load especially if the curvature is rather large. To the purpose of determining the buckling pressure load the effects of a pre-existing level of geometrical and technological imperfection, unavoidably caused by various manufacturing processes wer...
Results of calculational investigations into circulation of water and steam-and-water mixture in the PGV-1000 steam generator heat exchanger bundle used at NPPs with the WWER-1000 reactors, are considered. Model of water circulation in horizontal steam generator with submerged heating surface under conditions of steam generation irregularity along the heat transfer tubes is made. On the basis of the obtained data the assumption is made about water essential overflows from the hot collector zone into the cold one. Overflow rate over the upper line of the heat transfer tubes may constitute 0.7 m/s. The conclusion is made about the necessity to set up the vertical barrier which divides hot and cold sections of heat transfer tubes and helps to avoid water transverse overflows.
The behaviour of the wave function of the universe under the barrier for the anisotropic cosmological Bianchi type-IX model taking account of the scalar field is explored. In view of the known difficulties with the interpretation of multidimensional ones is offered. For this purpose in the frameworks of the semiclassical approach the system of characteristics equations relative to one variable is written out. This system describes a bundle of the characteristics along which the multidimensional problem is reduced to a one-dimensional one that allows to utilize the standard interpretation of the wave function as well as the usual Schroedinger equation. The obtained results for the Bianchi type-IX model are reduced to the following statement: the universe tunnels through the barrier from an isotropic state with small anisotropy that is necessary for providing a ling-lived inflation to derive the universe.
Fuel management simulations have been performed for 0.9% SEU CANFLEX fuel in the Wolsung-1. Based on earlier studies at AECL, the bi-directional, four-bundle-shift fuelling scheme was assumed. Time-averaged simulations resulted in an average discharge burnup of 13.0 MWd/kgU. The derived pin power envelope indicated that the peak linear element rating with CANFLEX fuel is 15% less than that obtained with 0.9% SEU 37-element fuel and there is little power boosting at high burnups. Calculated worths of the reactivity devices are sufficient to provide the control and safety requirements for CANFLEX 0.9% SEU fuel in the Wolsung-1 reactor. (Author).
A dry interim storage facility has been constructed at the Wolsung power plant in Korea. This dry storage facility has seven separated modules. There are 40 long slender cylinders in one module. In one cylinder, ten baskets where sixty CANDU spent fuel bundles are loaded are stacked and stored. For this dry storage facility, analyses and tests for hypothetical accident conditions that might occur while moving and storing the baskets into a cylinder were performed. In a demonstration test, one of test basket models did not satisfy one of the safety-related requirements. Thus, the revised basket designs were generated using a structural evaluation based on finite element analyses and specimen tests. Among these revised designs, one design was chosen as a final revised basket design. The fina...
In a nutshell, the existing Internet provides to us content in the forms of videos, emails and information served up in web pages. With Cloud Computing, the next generation of Internet will allow us to "buy" IT services from a web portal, drastic expanding the types of merchandise available beyond those on e-commerce sites such as eBay and Taobao. We would be able to rent from a virtual storefront the basic necessities to build a virtual data center: such as CPU, memory, storage, and add on top of that the middleware necessary: web application servers, databases, enterprise server bus, etc. as the platform(s) to support the applications we would like to either rent from an Independent Software Vendor (ISV) or develop ourselves. Together this is what we call as "IT as a Service," or ITaaS, bundled to us the end users as a virtual data center.
This paper describes the CANDU fuel development activities in Canada during 1997 through 1998. The activities include those of the Fuel Technology Program sponsored by the CANDU Owners Group. The goal of the Fuel Technology Program is to maintain and improve the reliability, economics and safety of CANDU fuel in operating reactors. These activities, therefore, concentrate on the present designs of 28-element and 37-element fuel bundles. The Canadian fuel development activities also include those of the Advanced Fuel and Fuel Cycle Technology Program at AECL. These activities concentrate on the development of advanced fuel designs and advanced fuel cycles, which among other advantages, can reduce the capital and fuelling costs, maintain operating margins in aging reactors, improve natural-uranium utilization, and reduce the amount of spent fuel. (author)
The report presents the results of experimental studies conducted to provide a description of the conditions which lead to the occurrence of critical heat flux (CHF), in Combustion Engineering (C-E) fuel assemblies using the C-E standard spacer grid. A CHF correlation is presented which is based on CHF data obtained in tests with electrically heated rod bundles representative of the C-E 14 x 14 and 16 x 16 array fuel assemblies. The results reported are for a uniform axial heat flux distribution. The experiments were conducted in the Medium Pressure Heat Transfer Flow Loop at the Chemical Engineering Research Laboratories at Columbia University.
Three experiments were conducted to study the behaviour of the new horizontal steam generator construction of the PACTEL test facility. In the experiments the secondary side coolant level was reduced stepwise. The experiments were calculated with two computer codes RELAP5/MOD3.1 and APROS version 2.11. A similar nodalization scheme was used for both codes so that the results may be compared. Only the steam generator was modeled and the rest of the facility was given as a boundary condition. The results show that both codes calculate well the behaviour of the primary side of the steam generator. On the secondary side both codes calculate lower steam temperatures in the upper part of the heat exchange tube bundle than was measured in the experiments. (orig.) 4 refs.
Three experiments were conducted to study the behaviour of the new horizontal steam generator construction of the PACTEL test facility. In the experiments the secondary side coolant level was reduced stepwise. The experiments were calculated with two computer codes RELAP5/MOD3.1 and APROS version 2.11. A similar nodalization scheme was used for both codes so that the results may be compared. Only the steam generator was modeled and the rest of the facility was given as a boundary condition. The results show that both codes calculate well the behaviour of the primary side of the steam generator. On the secondary side both codes calculate lower steam temperatures in the upper part of the heat exchange tube bundle than was measured in the experiments. (orig.).
In order to identify cells of maternal origin in CVS cultures, tissue from 1st trimester abortions were cultivated and the cultures stained in situ for X-chromatin. Convoluted cells and maternal fibroblasts were found to be positive. By chromosome analysis of cultures from 105 diagnostic placenta biopsies, obtained by the transabdominal route, metaphases of maternal origin were found in nine cases. In eight of these cases colonies of convoluted cells were observed. We conclude that convoluted cells are of maternal origin and are a reliable marker for maternal cell contamination in CVS cultures.
An assay system for the stem cell that colonizes the thymus and differentiates into T cells was developed, and by using this assay system the existence of two subpopulations of stem cells for T cell lineage was clarified. Part-body-shielded and 900-R-irradiated C57BL/6 (H-2b, Thy-1.2) recipient mice, which do not require the transfer of pluripotent stem cells for their survival, were transferred with cells from B10 X Thy-1.1 (H-2b, Thy-1.1) donor mice. The reconstitution of the recipient's thymus lymphocytes was accomplished by stem cells in the donor cells and those spared in the shielded portion of the recipient that competitively colonize the thymus. Thus, the stem cell activity of donor cells can be evaluated by determining the proportion of donor-type (Thy-1.1+) ...
Understanding prostate stem cells may provide insight into the origin of prostate cancer. Primary cells have been cultured from human prostate tissue but they usually survive only 15-20 population doublings before undergoing senescence. We report here that RC-170N/h/clone 7 cells, a clonal cell line from hTERT-immortalized primary non-malignant tissue-derived human prostate epithelial cell line (RC170N/h), retain multipotent stem cell properties. The RC-170N/h/clone 7 cells expressed a human embryonic stem cell marker, Oct-4, and potential prostate epithelial stem cell markers, CD133, integrin #alpha#2#beta#1"h"i and CD44. The RC-170N/h/clone 7 cells proliferated in KGM and Dulbecco's Modified Eagle Medium with 10% fetal bovine serum and 5 #mu#g/ml insulin (DMEM + 10% FBS + Ins.) ...
The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test t...
Introduction: Haploidentical transplantation, with extensive T cell depletion to prevent GvHD, is associated with a high incidence of infection-related deaths. The key challenge is to improve immune recovery with allogeneic donor T cells without triggering GvHD. As T regulatory cells (Tregs) controlled GvHD in pre-clinical studies, the present study evaluated the impact of an infusion of donor CD4/CD25 + Tregs, followed by an inoculum of donor mature T cells (Tcons) and positively immunoselected CD34 + cells in the setting of haploidentical stem cell transplantation. Patients and methods: Twenty-eight patients were enrolled in this study (22 AML; 5 ALL; 1 NHL). All received immunoselected Tregs (CliniMACS, Miltenyi Biotec) followed by positively immunoselected CD34 + cells together with Tc...
The presence of a high number of activated T cells in the bloodstream and spontaneous proliferation of peripheral blood mononuclear cells in vitro are striking characteristics of human T-cell leukemia...Full Text Available
The article is the second part of a review dealing with latest developments in the area of solar cell technologies and application. Physical principles, design and efficiency as well as advantages and disadvantages of GaAs- and CdS-solar cells are described. Power generation solar cell systems with voltage converters, combined solar cell/solar collector systems and thermoelectric solar systems are presented in the second part of the article.
The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test this hypothesis, flow cytometry ...
Cell therapy is a promising novel option for treatment of cardiovascular disease. Because the role of bone marrow-derived circulating progenitor cells (BM-CPCs) after cell therapy is less clear, we...Full Text Available
PCD (programmed cell death) in plants presents important morphological and biochemical differences compared with apoptosis in animal cells. This raises the question of whether PCD arose independently...Full Text Available
Although human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), the role of viral gene expression in the progression to and maintenance of the...Full Text Available
Bovine leukemia virus (BLV), a retrovirus related to human T-cell leukemia virus types 1 and 2, can induce persistent nonneoplastic expansion of the CD5+ B-cell population, termed...Full Text Available
Solid Oxide Fuel Cell (SOFC) is expected as a new power generation source. The development of SOFC is being conducted by CRIEPI, and so far several reports of the reults were presented. This report examines materials of SOFC. For the purpose, cells were made using some of typical materials and manufacturing processes, and cell performance tests were carried out.
Tube supports used in the tube bundles of PWR steam generators have consisted of mechanical devices located at intervals along the tube bundle. The presence of tube supports creates regions of restricted flow with altered flow patterns and increased pressure drop. An additional and very important effect is also the possibility of local complete vaporization or dryout occurring in the tube/support flow passage and crevices. The thermal/hydraulic conditions at which dryout occurs are of particular interest because of the possibility of the deposition of dissolved solids with the occurrence of dryout. As long term build-up of solid deposition could have a deleterious effect, knowledge of the conditions at which dryout occurs would possibly provide a means to avoid this build-up. A test program, sponsored by the Steam Generator Project Office of the Electric Power Research Institute, was conducted to determine the thermal/hydraulic conditions at ...
In-core thermal-hydraulics during a PWR reflood phase following a large-break LOCA are quite unique in comparison with two-phase flow which has been studied widely in previous researches, because the geometry of the flow path is complicated (bundle geometry) and water is at extremely low superficial velocity and almost under stagnant condition. Hence, some phenomena realized during a PWR reflood phase are not understood enough and appropriate analytical models have not been developed, although they are important in a viewpoint of reactor safety evaluation. Therefore, author investigated some phenomena specified as important issues for quantitative prediction, i.e. (1) void fraction in a bundle during a PWR reflood phase, (2) effect of radial core power profile on reflood behavior, (3) effect of combined emergency core coolant injection on reflood behavior, and (4) the core separation into two thermal-hydraulically different regions and the ...
Since 1975 All Volatile Treatment (AVT) has been the preferred method for controlling the secondary system operating environment in Westinghouse PWR plants. However, since AVT provides no buffering action against corrodent species present in the water as trace contaminants, utilities have initiated programs which combine control of contaminant ingress with total steam generator sludge management. The earliest applications of boric acid, to control denting type corrosion, began in 1978 and have continued up to the present time. Boric Acid has also been added as an inhibitor for SCC/IGA type corrosion since 1985. There are now approximately 30 plants operating with boric acid or boric acid/morpholine chemistry in the secondary system, and a growing number of plants where morpholine is being used as an additive to maintain pH and reduce iron transport attributable to erosion/corrosion. The impact of these modifications in the operating chemistry environment are examined for their ...
Three-dimensional computer simulation and analyses of the horizontal steam generator thermal-hydraulics of the WWER 1000 nuclear power plant have been performed for 50% and 75% partial loads, 100% nominal load and 110% over-load. Presented results show water and steam mass flow rate vectors, steam void fraction spatial distribution, recirculation zones, swell level position, water mass inventory on the shell side, and other important thermal-hydraulic parameters. The simulations have been performed with the computer code 3D ANA, based on the 'two-fluid' model approach. Steam-water interface transport processes, as well as tube bundle flow resistance, energy transfer, and steam generation within tube bundles are modelled with {sup c}losure laws{sup .} Applied approach implies non-equilibrium thermal and flow conditions. The model is solved by the control volume procedure, which has been extended in order to take into account ...
Three-dimensional computer simulation and analyses of the horizontal steam generator thermal-hydraulics of the WWER 1000 nuclear power plant have been performed for 50% and 75% partial loads, 100% nominal load and 110% over-load. Presented results show water and steam mass flow rate vectors, steam void fraction spatial distribution, recirculation zones, swell level position, water mass inventory on the shell side, and other important thermal-hydraulic parameters. The simulations have been performed with the computer code 3D ANA, based on the 'two-fluid' model approach. Steam-water interface transport processes, as well as tube bundle flow resistance, energy transfer, and steam generation within tube bundles are modelled with "closure laws". Applied approach implies non-equilibrium thermal and flow conditions. The model is solved by the control volume procedure, which has been extended in order to take into account the 3D flow of liquid and gas ...
Several steam generator tube rupture accidents have occurred at plants in the past. In this paper the Computational Multi-Fluid Dynamics (CMFD) investigation of the horizontal steam generator thermal-hydraulics during the tube rupture accident is performed. A guillotine of a steam generator U-tube is assumed with choked flow from the primary to the secondary side of the steam generator. We have computed water and steam velocity fields, steam volume fraction distribution on the steam generator secondary (shell) side, as well as the swell level increase. The simulation results are a support to the safety analyses of the steam generator tube rupture accident. Numerical simulation is performed with the multidimensional multi-fluid modelling approach. The two-phase flow around steam generator tubes in the bundle is modelled by the porous media approach. Interfacial mass, momentum and energy transfer are modelled with the closure laws. The governing equations are solved ...
The CANDU-type nuclear fuel localization project started in 1981, and mass-production system completed in 1987 through the pilot scale demonstration of fuel manufacturing. Since the completion of the mass-production system, about 24,000 fuel bundles (450 ton-U) had been delivered to Wolsung Nuclear Power Plant by the end of 1992, according to the fuel supply contracts with KEPCO. The superiority of KAERI-made nuclear fuel has been demonstrated by having achieved the highest utilization factor in the world in 1992. In 1993, as contracted, 4,824 fuel bundles well fabricated and delivered to Wolsung Nuclear Power Plant. The process improvement, quality control, safety management, safeguards of nuclear materials and various kinds of audits have also been performed in the course for fuel manufacturing. Especially in 1993, the difficulties of the reduction of participating work-force were overcome by improving the manufacturing techniques, and ...
The PVSCAN is an instrument designed to characterize silicon solar cell materials and devices. It performs a host of measurements that yield spatial maps of dislocation density, grain distribution, reflectance, and photoresponses from near-junction and the bulk of a solar cell.
The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial cells (McCoy cells) was evaluated by a fluorometric assay. At...Full Text Available
There is ample evidence suggesting that superantigens may act as a triggering factor in the pathogenesis of rheumatoid arthritis (RA). We investigated whether superantigen could activate T cells in...Full Text Available
SUMMARYThe cytolytic activity of natural killer (NK) cells is regulated by inhibitory receptors that detect the absence of self molecules on target cells. Structural studies of...Full Text Available
The proliferation of stem cell research, conflated with its ethical and moral implications, has led governments to attempt regulation of both the science and funding of stem cells. Due to a diversity...Full Text Available
Embryonic stem cells have the ability to develop into virtually any cell in the body, and may have the potential to treat medical conditions such as diabetes and Parkinsons disease. On August 9, 2001, President Bush announced that for the first time feder...
Background: In North America and Europe, 80% of invasive skin cancers are basal cell carcinoma while 20% are squamous cell carcinoma (SCC). In contrast, African studies reveal a preponderance...Full Text Available
BackgroundSpindle cell carcinoma (SpCC) is a rare microscopic type of cancer of the mouth and oropharynx. Although SpCC is thought to arise from squamous cell carcinoma (SCC), it...Full Text Available
This paper describes a radiation shield verification survey of a large hot cell at the Fast Flux Test Facility (FFTF). The following aspects of the shield test are discussed: description of the FFTF; description of the hot cell; the test procedures; radiation protection, and the test results.
... from Dr. Austin Smith of the Institute for Stem Cell Research, University of Edinburgh) was modified from the CGR8 ... to thank Dr. Austin Smith, the Institute for Stem Cell Research, University of Edinbu...
Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of...Full Text Available
Most genetic changes that promote tumorigenesis involve dysregulation of G1 cell cycle progression. A key regulatory site in G1 is a growth factor–dependent restriction point (R) where cells...Full Text Available
Target of rapamycin (TOR) kinases control cell growth through two functionally distinct multiprotein complexes. TOR complex 1 (TORC1) controls temporal cell growth and is sensitive to rapamycin, whereas...Full Text Available
... based, disease treatment remains promising, the emphasis for stem cell research from the biomedical research community is clear, and ... diagnosis as a novel source of embryos for stem cell research. Repr...
The cells of the endosperm of castor bean seeds (Ricinus communis) undergo programmed cell death during germination, after their oil and protein reserves have been mobilized. Nuclear...Full Text Available
Placental and placental-like alkaline phosphatase (PLAP) levels in the culture media of 87 cell lines of neoplastic and 'normal' origin were measured by a conventional immunosorbent enzymatic assay...Full Text Available
The rate and capacity for chloroform (CF) and trichloroethylene (TCE) transformation by a mixed methanotrophic culture of resting cells (no exogenous energy source) and formate-fed cells were measured....Full Text Available
A new method is described for continuously measuring cell turgor pressure (P), hydraulic conductivity (Lp), and volumetric elastic modulus (ε) in higher plant cells, using a pressure...Full Text Available
PURPOSE: To determine the frequency of ophthalmic abnormalities in patients with cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome) and T-cell lymphoma involving the skin and...Full Text Available
Neutral endopeptidase 24.11 (NEP, CD10) is a cell-surface enzyme expressed by prostatic epithelial cells that cleaves and inactivates neuropeptides implicated in the growth of androgen-independent prostate...Full Text Available
The primary aim of this study was to develop a model system that uses epidermal cells (keratinocytes and accessory pigmented cells) cultured on a reconstituted basement membrane biomatrix for use in...Full Text Available
Amorphous silicon solar cells have been shown to have efficiencies which degrade as a result of long exposure to light. Annealing such cells in air at a temperature of about 200.degree. C. for at least 30 minutes restores their efficiency.
Special red cells were found on the adaxial surface of tertiary pulvini of Mimosa pudica and experiments performed to determine the origin and function of these cells. Using anatomical...Full Text Available
Red cell transfusions are associated with the development of acute lung injury in the critically ill. Recent evidence suggests that storage induced alterations of the red blood cell (RBC) collectively...Full Text Available
Adhesion of Spirogyra (tentatively, Spirogyra fluviatilis) cells to glass is described. The cells of an algal filament can adhere to a substrate only when they are...Full Text Available
Many patients who undergo hematopoietic cell transplantation (HCT) present with anemia and have received red blood cell transfusions before HCT. As a result, iron overload is frequent and appears...Full Text Available
Understanding the interactions between herpesviruses and their host cells and also the interactions between neoplastically transformed cells and the host immune system is fundamental to understanding...Full Text Available
Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+...Full Text Available
... is known as "reproductive cloning." The Link to Stem Cell Research Stem cell research and research cloning are closely linked. Scientists in ... to arrive at a position on cloning and stem cell research. Many nations, including the UK, China, and South ...
Although most self-reactive T cells are eliminated in the thymus, mechanisms to inactivate or control T cells specific for extrathymic antigens are required and exist in the periphery. By investigating...Full Text Available
The glycolipid content of human non-seminomatous germ cell tumour cell lines correlates with their differentiation lineage. To analyse whether this reflects the situation in primary tumours, we studied...Full Text Available
One of the major decisions that germ cells make during their development is whether to differentiate into oocytes or sperm. In mice, the germ cells’ decision to develop as male or female depends...Full Text Available
DNA from the peripheral blood mononuclear cells of 17 different individuals infected with human T-cell lymphoma/leukemia virus type II (HTLV-II) was successfully amplified by the polymerase chain reaction...Full Text Available
It Peripheral blood progenitor enriched CD34+ cells (PBPC) are rather often used as stem cell background in cancer patients following high dose therapy. Keeping in mind that precursor dendritic cells (DCs) originate from haematopoietic progenitor cells, purified CD34+ cells might also serve as starting cells for ex-vivo production of DC. The aim of the present study is to develop a clinical grade procedure for ex-vivo production of DC derived from enriched CD34+ cells. Various concentrations of CD34+ cells were grown in gas-permeable Teflon bags with different serum-free and serum-containing media supplemented with GM-CSF, IL-4, TNF-a, SCF, Flt-3L and INF-a. Serum-free CellGroSCGM medium for 7 days followed by CellGroDC medium in 7 days gave equal results as serum-containing ...
Metastatic testicular germ cell tumours are cured in approximately 85% of patients using cisplatin-based combination chemotherapy. Patients who fail to respond have a poor prognosis, and there is a...Full Text Available
The first cell lineage specification in mouse embryo development is the formation of trophectoderm (TE) and inner cell mass (ICM) of the blastocyst. This article is to review and discuss the...Full Text Available
Zygotes of fucoid algae have long been studied as a paradigm for cell polarity. Polarity is established early in the first cell cycle and is then expressed as localized growth and invariant cell division....Full Text Available
Naturally occurring and contaminant ferromagnetic and ferrimagnetic particles have been found within or near cells, and might allow pulsed magnetic fields to create transient cell membrane opening ("pores")....Full Text Available
BackgroundClara cell protein (CC16), the main secretory product of bronchiolar Clara cells, plays an important protective role in the respiratory tract against oxidative stress and...Full Text Available
... ions. MATERIALS AND METHODS Cell Culture Culture of NT2/D1 cells was carried out as described previously (18, 19). NT2 cells were plated at a density of 2. ... ...
BackgroundPerfluorocarbons (PFC) are used to improve gas exchange in diseased lungs. PFC have been shown to affect various cell types. Thus, effects on alveolar type II (ATII) cells...Full Text Available
1. Paired or single recordings of paraventricular and/or supraoptic oxytocin cells at the beginning of suckling in urethane-anaesthetized rats enabled us to study cell recruitment and compare the characteristics...Full Text Available
Reaggregated cells from 6- to 8-day-old mouse cerebella have been used to raise antibodies in rabbits. The interaction of these antibodies with cerebellar cell surface components was assessed by cytotoxicity...Full Text Available
Cells have an internal compass that enables them to move along shallow chemical gradients. As amoeboid cells migrate, signaling events such as Ras and PI3K activation occur spontaneously on pseudopodia....Full Text Available
The cell types involved in the cellular immune response were studied with the GVH in vitro as a test system. Comparison of the activities of cells of different lymphoid organs in the...Full Text Available
Species differences in lifespan have been attributed to cellular survival during various stressors, designated here as ‘cell resilience’. In primary fibroblast cultures, cell...Full Text Available
Stem cell therapies for neurodegenerative disorders require accurate delivery of the transplanted cells to the sites of damage. Numerous studies have established that fluid injections to the hippocampus...Full Text Available
We review the application of C. elegans as a model system to understand key aspects of stem cell biology. The only bona fide stem cells in C. elegans...Full Text Available
One of the main obstacles encountered when trying to culture human seminoma (SE) cells in vitro is massive degeneration of the tumour cells. We investigated whether dissociation of tumour tissue, to...Full Text Available
SummaryFor mammalian somatic cells the importance of microtubule cytoskeleton integrity in interphase cell cycle progression is uncertain. The loss, diminishment, or stabilization...Full Text Available
BACKGROUND--Interstitial lung diseases are characterised by the recruitment of mononuclear cells to disease sites where maturation occurs and activation products, including lysozyme (LZM), are released....Full Text Available
BackgroundA fundamental requirement for the exploitation of embryonic stem (ES) cells in regenerative medicine is the ability to reproducibly derive sufficient numbers of cells of...Full Text Available
Cultured mouse or human embryonic stem (ES) cells provide access to all of the genes required to elaborate the fundamental components and physiological systems of a mammalian cell. Chemical or insertional...Full Text Available
ObjectiveThe goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic α cell hyperplasia...Full Text Available
Fate maps are generated by marking and tracking cells in vivo to determine how progenitors contribute to specific structures and cell types in developing and adult tissue. An advance in this...Full Text Available
It may result in acute radiation syndrome after body is exposed to ionizing radiation. The one of long-term effects of irradiation injury is leukemia. The bone marrow cells (BMC) transplantation including stem cells is the only effective therapy for acute radiation syndrome patients. Recently, with the advancement of stem cell research that the stem cells have multipotential and can convert each other, it may supply the new stem source for the irradiation injury patients. At the same time with the further research of radioprotective reagents, the hematopoietic stem cells proliferation after irradiation injury is promoted
In the last two years, rapid progress has been made in the energy conversion efficiencies of GaAs solar cells fabricated from molecular beam epitaxy (MBE) material. The efficiencies of cells fabricated from MBE material are now comparable with those fabricated from metal-organic chemical vapor deposition material, even for cells of dimension 2 cmx4 cm. This paper reviews the progress in MBE cell efficiencies. Also discussed is the role oval defects play in GaAs diode and solar cell performance. (orig.).
As concern regarding global environmental problems such as the greenhouse effect and acid rain has increased, so too has the demand for commercially viable solar cells as a clean energy source. Interest in amorphous silicon (a-Si) solar cells has been particularly high, due to their low cost. Technological developments in the field of a-Si solar cells are discussed from the viewpoints of fabrication process, materials, and cell structures. Various applications and systems that take advantage of the a-Si solar cell are then introduced. Finally, future prospects are mentioned
Transdifferentiation of an individual's own cells into functional differentiated cells to replace an organ's lost function would be a personalized approach to therapeutics. In this two part series, we will describe the progress toward establishing functional transdifferentiated adrenal cortical cells. In this article (Part 2), we describe the disorders of the adrenal cortex, therefore establishing why there is the need for personalized cell-based therapy for individuals with these disorders. We then present our pilot studies of cell transdifferentiation toward an adrenal cortical fate using genes described in the first article of this pair (Part 1).
In this contract, Laser-assisted processing techniques for producing high-quality solar cell metallization patterns are being investigated, developed, and characterized. The tasks comprising these investigations are outlined. Four new batches of solar cells were processed, in addition to several test runs on wafers, using the laser decomposition of spun-on silver neodecanoate to metallize cells. Decomposition of silver neodecanoate was carried out at different laser powers on different cells on a given wafer to determine whether this would have any effect on cell performance. A one watt laser power gave an electroplated linewidth of 50 microns , while at 8 watts the line width was 90 microns.
We report on multijunction GaInP/GaAs photovoltaic cells with total-area efficiencies of 29.5% at one-sun concentration and air mass (AM) 1.5 global and 25.7% one-sun, AM0. These values represent the highest efficiencies achieved by any solar cell under these illumination conditions. Three key areas in this technology are identified and discussed: the grid design, front surface passivation of the top cell, and bottom surface passivation of both cells. Aspects of cell design related to its operation under different solar spectra and under concentration are also discussed.
The theory for the general case of solar cells operating inside integrating cavity receivers is established. This is applied to the particular case of different configurations of silicon and GaAs cells. The results of the analysis show that a composite system of silicon and GaAs cells manufactured using relatively simple technology could reach an efficiency of 34%. The optimal configuration is that in which the GaAs cells are placed in the directly illuminated area of the receiver and the silicon cells are placed in the indirectly illuminated area of the receiver. (orig.).
The coupling between cerebral metabolic rate of oxygen (CMRO2) and blood flow (CBF) in response to visual stimulation was evaluated by means of a model of oxygen delivery. The model predicted a nonlinear relationship between stimulus-evoked changes of oxygen consumption and blood flow. The magnitude of the CMRO2/CBF ratio index (IO2) was used to indicate the degree of flow-metabolism coupling prevailing in specific areas of the brain during physiological stimulation. Therefore, the index provided a measure of the blood oxygenation level dependent (BOLD) magnetic resonance contrast. To evaluate the changes of IO2 in response to visual stimulation, the model was applied to the effect of a changing flicker rate of a visual stimulus on the magnitudes of CBF, CMRO2, and oxygen diffusion capacity, in the human brain. Positron emission tomography (PET) was used to measure the CBF and the CMRO2 in 12 healthy volunteers who viewed a cross-hair (baseline) or a yellow-blue ...
To assess the contribution of adrenal-derived androgens in women with hirsutism, adrenal scintigrams under dexamethasone suppression (DS) were performed on 35 women with increasing facial or body hair and irregular or absent menses. Based upon the DS regimen chosen (8 mg/d for 2 days or 4 md/d for 7 days before the injection of 6..beta..-(/sup 131/I)iodomethylnorcholesterol), three imaging patterns were identified. The first was the absence of uptake before 3 days (8-mg DS) or before 5 days (4-mg DS) after injection. This imaging pattern was seen in 17 of the 35 patients studied and was considered normal. The second pattern was bilateral uptake earlier than 3 days (8-mg DS regimen) or 5 days (4-mg DS) after injection. This was seen in 13 of the 35 patients and was interpreted as bilateral early visualization. Adrenal-vein catheterization performed on six patients with this pattern showed increased adrenal-vein testosterone. The third pattern, observed in five ...
pletely new PW fuel cell model had to be developed for CINDA. Several ...... following linear equation, which is used in the SINDA fuel cell model: ...
ObjectiveTo achieve osteochondral regeneration utilizing transplantation of cartilage-lineage cells and adequate scaffolds, it is essential to characterize the behavior of transplanted...Full Text Available
BackgroundThe evolution of eukaryotic cells is widely agreed to have proceeded through a series of endosymbiotic events between larger cells and proteobacteria or cyanobacteria,...Full Text Available
The molecular structure, chemical properties, and biological function of the xyloglucan polysaccharide isolated from cell walls of suspension-cultured sycamore (Acer pseudoplatanus)...Full Text Available
... Program: Quallion Matrix Design (small cells) - Investigate the feasibly of a hybrid battery matrix composed of small D-sized cells for use in HEVs ...
The most advanced frontier of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is represented by the use of an HLA-partially matched relative as donor. In this type of transplantation, donor-derived natural killer (NK) cells, which are alloreactive towardtoward recipient cells, significantly contribute to the eradication of leukemia blasts. Alloreactive NK cells may also kill host dendritic cells and T lymphocytes, thus preventing graft-versus-host disease and graft rejection, respectively. Sophisticated strategies of adoptive infusion of T-cell lines/clones specific for the most life-threatening pathogens (namely cytomegalovirus, Epstein-Barr virus, Aspergillus and Adenovirus) have been envisaged, and successfully tested in a few pilot trials, to protect the recipient in the...
Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to significant cell-to-cell variations in mRNA and protein levels. This variation...Full Text Available
Conditions were found in which Chlamydomonas reinhardi exhibits a circadian alteration of its cell surface, measured as ability to stick to glass. Under these same conditions the cells...Full Text Available
To examine the possibility that mast cells have a central role in the pathogenesis of hypersensitivity pneumonitis, 20 patients with this disease were studied with the aim of seeking evidence for mast...Full Text Available
Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory...Full Text Available
There is a requirement for a noninvasive technique to monitor stem cell differentiation. Several candidates based on optical spectroscopy are discussed in this review: Fourier transform infrared (FTIR)...Full Text Available
Diverse cell polarity networks require positive feedback for locally amplifying distributions of signalling molecules at the plasma membrane1. Additional...Full Text Available
Morphological, Electrophysiological and Behavioral Investigations of the Nervous Tissue Developed from the Embryonic Matrix Zone Cells of the Dorsolateral Walls of Lateral Ventricles, Implanted into the Lesioned Regions of the Adult Rat's Brain
Jun 10, 2011 ... The PSSC is a picosatellite designed to test the space environment by providing a testbed to gather data on new solar cell technologies.
The present volume on modeling of batteries and fuel cells discusses the significance of the effectiveness factor for flooded porous electrodes, active pore distribution spectroscopy for characterizing porous battery electrodes, the agglomerate model for porous electrodes, and dynamic-performance measurements of battery cells for electric vehicles and other applications. Attention is given to mathematical modeling of a primary zinc/air battery, mathematical modeling of Grace Li-TiS2 cells, modeling of electrocrystallization processes in battery systems, and rotating disk electrode studies in molten Li/K carbonate eutectic. Topics addressed include the variability of nickel oxide cathode dissolution in molten carbonate fuel cells, water transport properties of fuel cell ionomers, modeling water content effects in polymer electrolyte fuel cells, and computer ...
Many mutations associated with retinal degeneration lead to the production of misfolded proteins by cells of the retina. Emerging evidence suggests that these abnormal proteins cause cell death...Full Text Available
Methods for improving the sensitivity of scintillation cells for radon concentration measurements were studied with emphasis on improving light collection efficiency. This allows the length and hence the volume of the cell to be increased. Variables studied were choice of scintillator material, its method of application and thickness, length of cell, cell material, type and configuration of reflectors, choice of photomultipliers, and factors affecting background. Response from various areas of the cell surface was studied with an alpha source and with radon filling. Coating the window with phosphor was found to be counter-productive. The optimum results obtained were with the inside of the cell (other than the window) covered with a thick layer of ZnS(Ag), or with a thick layer of reflective material coated with a thin layer of phosphor. With it, a 10 cm ...
Methods for improving the sensitivity of scintillation cells for radon concentration measurements were studied with emphasis on improving light collection efficiency. This allows the length and hence the volume of the cell to be increased. Variables studied were choice of scintillator material, its method of application and thickness, length of cell, cell material, type and configuration of reflectors, choice of photomultipliers, and factors affecting background. Response from various areas of the cell surface was studied with an alphy source and with radon filling. Coating the window with phosphor was found to be counter-productive. The optimum results obtained were with the inside of the cell (other than the window) covered with a thick layer of ZnS(Ag), or with a thick layer of reflective material coated with a thin layer of phosphor. With it, a 10 cm ...
Proliferating cells have been immunophenotypically characterized in lymph node and bronchoalveolar lavage (BAL) samples obtained from patients with active and inactive sarcoidosis with the cell-cycle-related...Full Text Available
Erythrocytes serve as reservoirs for cis- and trans-epoxyeicosatrienoic acids (EETs). Incubation of rat red blood cells (RBCs) with cis- and...Full Text Available
PASTICCINO (PAS) genes are required for coordinated cell division and differentiation during plant development. In loss-of-function pas mutants,...Full Text Available
PurposeTo analyze the expression of apoptosis and cell proliferation molecules in pterygium tissues of Chinese patients.MethodsThirty-three pterygia...Full Text Available
Proton exchange membrane (PEM) fuel cells are energy sources that have the ... for H2 /02 PEM fuel cells because their catalysts have properties suitable for 0 ...
Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo(a)pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors. 2 tabs.
... with the loosening of Bush-era restrictions on stem cell research, a move that was widely hailed by the ... The first two explore the contentious debate over stem cell research. Using a series of intervie...
The existence of stem cells committed to the T lymphoid lineage was deduced from studying how rat T and B stem cells differ in their expression of membrane W3/13 antigen and in their susceptibility in vivo to gamma irradiation. Stem cell activity of rat bone marrow and fetal liver was measured in long-term radiation chimeras using B and T cell alloantigenic surface markers to identify the progeny of donor cells. Monoclonal mouse anti-rat thymocyte antibody W3/13 labeled approximately 40% of fetal liver cells and 60-70% of young rat bone marrow cells (40% brightly, 25% dimly). Bright, dim, and negative cells were separated on a fluorescence-activated cell sorter. All B and T lymphoid stem cells in fetal liver were W3/13 bright, as were B lymphoid stem cells in ...
Cancer, by definition, is a proliferative disease. The fundamental scientific issue explored at the international symposium "Cell Proliferation and Chemical Carcinogenesis" was the impact of chemically...Full Text Available
Cells of the mononuclear phagocyte lineage have the capability to adhere to and fuse with each other and to differentiate into osteoclasts and giant cells. To investigate the macrophage adhesion/fusion...Full Text Available
Abstract: In many biological processes heterogeneity within clonal cell populations is an important issue. One of the most striking examples is a population of cancer cells in which after a common, identical death signal some cells die whereas others survive. The reason for this heterogeneity is intrinsic and extrinsic noise. In this paper we present a mechanistic multi-scale modeling framework for cell populations, in which the dynamics of every individual cell is captured by a parameter dependent stochastic differential equation (SDE). Heterogeneity among individual cells is accounted for by differences in parameter values, modeling extrinsic influences. Based on the statistical properties of the extrinsic noise and the SDE model for the individual cell, a partial differential equation (...
We present a sample preparation method for measuring magnesium in individual whole lymphocytes by electron probe X-ray microanalysis. We use Burkitt's lymphoma cells in culture as the test sample and compare X-ray microanalysis of individual cells with atomic absorption analysis of pooled cell populations. We determine the magnesium peak-to-local continuum X-ray intensity ratio by electron probe X-ray microanalysis and calculate a mean cell magnesium concentration of 39 +/- 19 mmol/kg dry weight from analysis of 100 cells. We determine a mean cell magnesium concentration of 34 +/- 4 mmol/kg dry weight by atomic absorption analysis of pooled cells in three cell cultures. The mean cell magnesium concentrations determined by the two methods are not significantly different. We find a 10% coefficient of ...
May 31, 2011 ... A Theoretical Solid Oxide Fuel Cell Model for System Controls and Stability Design AUTHOR(S): Kopasakis, George; Brinson, Thomas; Credle, ...
The purpose of this review is to consider the hypothesis that cancer frequently originates from stem cells. Using the spleen transplantation assay where stem cells were transplanted in the spleen of mice lethally irradiated by ionizing radiation, the author undertook a study aimed at defining the risk of radiogenic cancer per susceptible cells with use of rat radiogenic mammary and thyroid cancers because of the high incidences of these cancers in a-bomb survivors. Measured were the number of cancer-susceptible cells initially present in the tissue, the number of such cells that survived at a given dose and the number of cancers that developed per surviving cell. Thyroid cell differentiation and proliferation in rats transplanted with thyroid cells were enhanced by thyroidectomy and low iodine diet. Further, the ...
Physiological functions are carried out by differentiated cells, with finite lifespans, which age and need to be replaced. In young individuals, tissue functions are sustained at optimal levels because cellular dysfunction and cell loss are balanced by the emergence of newly differentiated cells as stem cells and their partially differentiated descendants replicate. However, with the passage of time the mitotic rates of these cells diminish. Eventually, replications occur too infrequently to offset the loss. It is at this point that the tissue begins to show structural changes and declining function which, as they become pervasive, are identified as ageing. In this paper the theory is set forth that: (1) Diminishing mitotic activity in older tissues results from limited stem cell replicative capacity. (2) All stem cells, regardless of ...
Bone marrow is one of the most radiosensitive organs. Irradiation causes a marked decrease in the total number of hematopoietic cells in the bone marrow. The reticular meshwork structure of marrow stromal cells, however, is relatively resistant to irradiation. Unimpaired stromal cell structure has been thought to be a prerequisite for the repopulation of hematopoietic cells during recovery from the effects of irradiation. The reticular framework is maintained by cell adhesion apparatuses such as gap junctions. The in vitro radiobiologic survival values of a cloned stromal cell line, H-1/A, were studied (n = 1.8, D0 = 138 cGy). Radiation doses of up to 4000 cGy had no detectable effects on the production of colony-stimulating factor 1. H-1/A cells communicate with each other via gap junctions as determined by the sensitive dye-transfer ...
Bone marrow is one of the most radiosensitive organs. Irradiation causes a marked decrease in the total number of hematopoietic cells in the bone marrow. The reticular meshwork structure of marrow stromal cells, however, is relatively resistant to irradiation. Unimpaired stromal cell structure has been thought to be a prerequisite for the repopulation of hematopoietic cells during recovery from the effects of irradiation. The reticular framework is maintained by cell adhesion apparatuses such as gap junctions. The in vitro radiobiologic survival values of a cloned stromal cell line, H-1/A, were studied (n = 1.8, D0 = 138 cGy). Radiation doses of up to 4000 cGy had no detectable effects on the production of colony-stimulating factor 1. H-1/A cells communicate with each other via gap junctions as determined by the sensitive dye-transfer ...
The cell is modeled as an ellipsoid with shell and the surface stress distribution calculated by means of the Maxwell Stress Tensor. The cell membrane is treated as incompressible material having both bending and shear energies of deformation. Employing the principle of virtual work, cell volume (and hence shape) is computed as a function of the external field strength and orientation with respect to the field. The following results were obtained: (1) The surface stresses that develop or the cell membrane are distributed having both normal and tangential components that act together to produce a rounding of the cell. (2) If the tangential component of the stress is ignored, then higher field strengths are needed to produce similar deformation (shape change) of cells. (3) The threshold value of the applied field, i.e, the field strength at which the volume ...
The field of stem cell research was revolutionized with the advent of induced pluripotent stem cells. By reprogramming somatic cells to pluripotent stem cells, most ethical concerns associated with the use of embryonic stem cells are overcome, such that many hopes from the stem cell field now seem a step closer to reality. Several methods and cell sources have been described to create induced pluripotent stem cells and we discuss their characteristics in terms of feasibility and efficiency. From these cells, cardiac progenitors and cardiomyocytes can be derived by several protocols and most recent advances as well as remaining limitations are being discussed. However in the short time period this technology has been around, evidence emerges that induced pluripotent stem cells may ...
In order to study the neurobiological basis of seasonal changes in hippocampal structure and function, the rate of cell proliferation was examined in male and female wild meadow voles captured during different seasons. We found that the number of [3H]thymidine-labeled cells varied across the seasons and across sex in the meadow vole. Non-breeding female meadow voles had a higher rate of cell proliferation and cell death than males captured during either season or breeding females. These seasonal changes in the female meadow vole were associated with both fluctuating levels of adrenal steroids and gonadal steroids. Estradiol level was highly correlated with both the number of [3H]thymidine-labeled cells and the number of pyknotic cells in female meadow voles, with high levels of estradiol being associated with low levels of cell proliferation ...
The authors describe an effect of suppression of invasion of the guinea pig eye conjunctiva and the HEp-2 epithelial cells by virulent Sh. flexneri bacilli, with a simultaneous administration of the same dose of avirulent shigella mutants, genetically connected with them. The data of morphological study and experiments with 3H-glucose labeled shigellae carried out on the cell species model indicated that the bacterial competition for the specific sites for absorption on the epithelial cells underlay the observed phenomenon. PMID:331774
Hyperosmotic stress is known to significantly enhance net uptake of inorganic ions into plant cells. Direct evidence for cell turgor recovery via such a mechanism, however, is still lacking. In the...Full Text Available
A new fabrication process is being developed which significantly improves the efficiency of metal-semiconductor solar cells. The resultant effect, a marked increase in the open-circuit voltage, is produced by the addition of an interfacial layer oxide on the semiconductor. Cells using gold on n-type gallium arsenide have been made in small areas (0.17 sq cm) with conversion efficiencies of 15% in terrestrial sunlight.
Epidermal gamma delta T cells (γδ T) and Langerhans cells (LC) are immune cells altered by exposure to ultraviolet radiation (UVB), a powerful stressor resulting in immune suppression....Full Text Available
The AT and T Round Cell has recently become a viable alternative to the conventional, rectangular, lead acid storage batteries in Class 1E applications at US nuclear generating stations. This paper discusses the qualification of the Round Cell for nuclear generating stations, its principal design attributes, the types of Class 1E applications most suited for the Round Cell, and industry experience related to its installation and operation.
Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that,...Full Text Available
Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.
IntroductionThe phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to...Full Text Available
The origin of the epithelial and myoepithelial cells in the human breast has not been delineated. In this study we have addressed whether luminal epithelial cells and myoepithelial cells are vertically connected, i.e., whether one is the precursor for the other. We used a primary culture assay allowing preservation of basic phenotypic traits of luminal epithelial and myoepithelial cells in culture. The two cell types were then separated immunomagnetically using antibodies directed against lineage-specific cell surface antigens into at best 100% purity. The cellular identity was ascertained by cytochemistry, immunoblotting, and 2-D gel electrophoresis. Luminal epithelial cells were identified by strong expression of cytokeratins 18 and 19 while myoepithelial cells were recognized by expression of vimentin and ...
Murine embryonic stem (ES) cells have unusually long telomeres, much longer than those in embryonic tissues. Here we address whether hyper-long telomeres are a natural property of pluripotent stem cells,...Full Text Available
The state of chromatin during the cell cycle was examined using synchronized cultures of CHO hamster cells. Results support Mazia's dynamic chromosome cycle model and indicate that DNA-interactive chemotherapeutic agents elicit different types of kinetic responses in treated cells, suggesting a degree of specificity of interaction between various alkylating and intercalating agents and the genome. Effects of sarkosyl crystals, heparin, and chemotherapeutic agents, neocarzinostatin and adriamycin, on chromation are discussed. (HLW)
The transformation of two different types of glial cells has been studied using an in vivo-/in vitro model and a complete in vitro model. The purpose of the study and to define in vitro model systems is to study the the neoplastic transformation of pure populations of glial cells. Data are presented to demonstrate that the transformed cells are glial and tumorigenic. (ACR)
BackgroundAberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role...Full Text Available
The zinc-air battery/fuel cell is an old technology invented one hundred years ago. However, there is renewed interest in this technology in response to the growing need for clean energy technology. The zinc-air battery/fuel cell is more attractive than similar technologies because its characteristics include high power density, safe operation and storage, and low cost. Zinc-air battery/fuel cells can be made in milliwatts to mega watts to accommodate different applications. The zinc-air battery/fuel cell has four major designs, namely primary, mechanically rechargeable, continuous feed and electrically rechargeable zinc-air battery/fuel cells. Among the different designs, the most common is the air cathode. There are 3 generations of catalysts used in the air cathodes. This paper discussed the different designs of the zinc-air battery/fuel cell, and more ...
Sphere-forming abilities in culture condition are considered a hallmark of cancer stem-like cells, which represents tumor cell invasiveness and stem-like characteristics. We aimed to show that the sphere-forming subpopulation of human malignant melanoma cell line WM-266-4 acts differently to zebrafish embryo extracts compared with their bulk counterpart. Spheres were maintained in neural stem cell culture conditions. The embryos of zebrafish at specific developmental stages were collected and the extracts were purified under 100 kDa. Spheres were treated with embyo extracts and proliferation assay and immunocytochemistry were conducted. Spheroid cells expressed nestin and epidermal growth factor receptor (EGFR) but not melanoma antigen recognized by T-cells (MART)1, indicating their stem-l...
Summary The effects of high-intensity pulsed electromagnetic stimulation (HIPEMS) on proliferation and differentiation of neonatal rat neural stem cells in vitro were investigated. Neural stem cells derived from neonatal rats were exposed to 0.1 Hz, 0.5-10 Tesla (T) [8 groups of B-I, respectively], 5 stimuli of HIPEMF. The sham exposure controls were correspondingly established. Inverted phase contrast microscope was used to observe the cultured cells, MTT assay to detect the viability of the cells as expressed by absorbance (A) value, and flow cytometry to measure differentiation of neural stem cells. The results showed that A values of neural stem cells in both 3.0 T and 4.0 T groups were significantly higher than the other groups 24 to 168 h post HPEMS, indicating a strong promotion of ...
A numerical model is developed to study electrolyte dependent kinetics in fuel cells. The model is based on the Poisson-Nernst-Planck (PNP) and generalized-Frumkin-Butler-Volmer (gFBV) equations, and is used to understand how the diffuse layer and ionic transport play a role in the performance difference between acidic and alkaline systems. The laminar flow fuel cell (LFFC) is used as the model fuel cell architecture to allow for the appropriate comparison of equivalent acidic and alkaline systems. We study the overall cell performance and individual electrode polarizations of acidic and alkaline fuel cells for both balanced and unbalanced electrode kinetics as well as in the presence of transport limitations. The results predict cell behavior based on electrolyte composition that strongly...
Cyclooxygenase-2 (COX-2) content is increased in many types of tumor cells. We have investigated the mechanism by which resveratrol, a stilbene that is pro-apoptotic in many tumor cell lines, causes apoptosis in human head and neck squamous cell carcinoma UMSCC-22B cells by a mechanism involving cellular COX-2. UMSCC-22B cells treated with resveratrol for 24 h, with or without selected inhibitors, were examined: (1) for the presence of nuclear activated ERK1/2, p53 and COX-2, (2) for evidence of apoptosis, and (3) by chromatin immunoprecipitation to demonstrate p53 binding to the p21 promoter. Stilbene-induced apoptosis was concentration-dependent, and associated with ERK1/2 activation, serine-15 p53 phosphorylation and nuclear accumulation of these proteins. These effects were blocked by ...
...Polymer Fuel Cells Challenge Publications News Events Login Register Search Content type All Web pages Case studies Publications News Video Home ...Buildings Carbon capture & storage Combined heat & power Electricity transmission & distribution Energy storage Fuel cells Geothermal Hydroelectric Hydrogen Industry Lighting Marine Metering Nuclear Solar Transport Wind ...Home Emerging technologies Current focus areas Polymer Fuel Cell Challenge Polymer Fuel Cells Challenge The objective of the Polymer Fuel Cells Challenge is to develop,...prove and commercialise novel polymer fuel cell technologies that have the potential to deliver a step-change in overall system cost. What are ...
To determine whether PKH26 labeling affects the morphologies, phenotypes, proliferation, and secretion abilities of human umbilical mesenchymal stromal cells (HUMSCs) were investigated. Isolated HUMSCs were labeled with PKH26, and cell morphology was observed under microscope. Cell cycle, apoptotic cell death, expression of PKH26, and the proliferation rate were evaluated. Additionally, fluorescence intensity of PKH26 labeling at different passage times was quantified. There were no detectable differences in cell morphology, cell growth, and proliferation rate after PKH26 labeling. In addition, fluorescence intensity of PKH26 labeling was gradually reduced with increase of the passage times. The PKH26 labeling disappeared after passage six times. In summary, PKH26 labeling is a safe and ef...
Recent improvements in cell purification and transplantation techniques have contributed to the identification of cell populations known as tumor-initiating cells (TIC). This discovery has led to the -cancer stem cell hierarchy- concept, which holds that tumors are organized as a hierarchy of malignant tissues sustained by such TIC. However, this concept remains controversial. In this review, we examine recent advances in cancer stem cell research that have been generated from studies of Philadelphia (Ph) chromosome-positive leukemia. The abnormal Ph chromosome, which arises from a translocation creating the BCR-ABL1 fusion gene, is most commonly associated with chronic myelogenous leukemia (CML) and precursor B cell acute lymphoblastic leukemia (B-ALL). Examination of the pathophysiology ...
Epigenetic regulations of genes by reversible methylation of DNA (at the carbon-5 of cytosine) and numerous reversible modifications of histones play important roles in normal physiology and development, and epigenetic deregulations are associated with developmental disorders and various disease states, including cancer. Stem cells have the capacity to self-renew indefinitely. Similar to stem cells, some malignant cells have the capacity to divide indefinitely and are referred to as cancer stem cells. In recent times, direct correlation between epigenetic modifications and reprogramming of stem cell and cancer stem cell is emerging. Major discoveries were made with investigations on reprogramming gene products, also known as master regulators of totipotency and inducer of pluoripotency, na...
The key factors of enzymatic lysis of cells are the interaction between the enzyme and the cell - catalytic and non-catalytic adsorption of enzyme on cell surface. Here, the studies of lysis of intact Escherichia coli cells by chicken egg white lysozyme were performed. It was found that the ionic strength has a dual effect onto the system. On the one hand, the desorption constant of the enzyme increases with the increase of the solution ionic strength, which results in a better enzyme performance. On the other hand, due to the higher osmosis, the cell lysis rate decreases with the increasing of ionic strength of the system. It was found that pH 8.6 and 30mM NaCl are optimal conditions for lysis of E. coli cells by lysozyme.
Ex vivo expanded peripheral blood progenitor cells (PBPC) have been shown to provide rapid neutrophil engraftment, and in some patients, to eliminate neutropenia after transplantation to support high-dose chemotherapy. However, the effect of expansion culture on stem cell content and potential loss of stem cells caused by induction of differentiation remains a concern. We have transplanted 21 patients with breast cancer with expanded autologous PBPC, with 11 patients receiving expanded PBPC as their sole hematopoietic cell source. In these studies, the CD34+ cells were selected and cultured for 10 days in defined media containing 100 ng/mL each of recombinant human stem cell factor (rhSCF), recombinant human granulocyte colony stimulating factor (rhG-CSF), and recombinant human megakaryocy...
A laser beam apparatus and method for analyzing, inter alia, the current versus voltage curve at the point of illumination on a solar cell and the open circuit voltage of a solar cell. The apparatus incorporates a lock-in amplifier, and a laser beam light chopper which permits the measurement of the AC current of the solar cell at an applied DC voltage at the position on the solar cell where the cell is illuminated and a feedback scheme which permits the direct scanning measurements of the open circuit voltage. The accuracy of the measurement is a function of the intensity and wavelength of the laser light with respect to the intensity and wavelength distribution of sunlight and the percentage the dark current is at the open circuit voltage to the short circuit current of the solar cell.
We report for the first time a relationship between the Tpl-2/cot oncogene and Mouse Mammary Tumor Virus (MMTV) associated transformation of mammary gland cells. A sub-genomic library generated from a primary mammary gland tumor yielded a novel MMTV integration site which disrupted the Tpl-2/cot proto-oncogene between exons 7 and 8. Comparison of a cell line derived from normal mammary gland (comma-D) and a cell line established from an MMTV induced mammary tumor (GR) demonstrated similar rearrangements within Tpl-2/cot for the GR cells but not in the comma-D cells. These rearrangements in the cell line were accompanied by an increase in the level of Tpl-2/cot specific mRNA. This data suggests that Tpl-2/cot expression may be important in epithelial cell transformation or tumor progression. PMID:8934549
Abstract Human mesenchymal stem cells (hMSCs) may be used for therapeutic applications. Culture conditions such as the serum source may impact on cell quality and the onset of replicative senescence. We have examined the effect of culturing hMSCs in autologous serum (AS) versus fetal bovine serum (FBS) on factors involved in in vitro replicative senescence. hMSCs from four donors were cultured in 10% FBS or 10% AS until they reached senescence. Cells were harvested at early passage and near senescence to study factors known to be involved in cellular senescence. The number of population doublings till senescence was similar for cells cultured in FBS, but varied greatly for hMSCs cultured in AS. FBS cells accumulated in S phase of cell cycle. This could not be explained by increased express...
Heart cells from the clam Ruditapes decussatus were routinely cultured with a high level of reproducibility in sea water based medium. Three cell types attached to the plastic after 2?days and could be maintained in vitro for at least 1?month: epithelial-like cells, round cells and fibroblastic cells. Fibroblastic cells were identified as functional cardiomyocytes due to their spontaneous beating, their ultrastructural characteristics and their reactivity with antibodies against sarcomeric ?-actinin, sarcomeric tropomyosin, myosin and troponin T-C. Patch clamp measurements allowed the identification of ionic currents characteristic of cardiomyocytes: a delayed potassium current (I K?slow) strongly suppressed (95%) by tetraethylammonium (1?mM), a fast inactivating potassium current (I K?fas...
Human pluripotent stem cells hold promising potential in many therapeutics applications including regenerative medicine and drug discovery. Over the past three decades, embryonic stem cell research has illustrated that embryonic stem cells possess two important and distinct properties: the ability to continuously self-renew and the ability to differentiate into all specialized cell types. In this article, we will discuss the continuing evolution of human pluripotent stem cell culture by examining requirements needed for the maintenance of self-renewal in vitro. We will also elaborate on the future direction of the field toward generating a robust and completely defined culture system, which has brought forth collaborations amongst biologists and engineers. As human pluripotent stem cell re...
Pro-inflammatory cytokines may directly influence the viability and metabolic function of colonic epithelial cells (CEC) as an early event in the development of inflammatory bowel disease. We report here that TNF-alpha+IFN-gamma induced a synergistic, concentration-dependent decline in butyrate oxidation, an essential energy supply, in HT-29 and DLD-1 cells. TNF-alpha+IFN-gamma induced a parallel profound decline in cell viability in HT-29 cells, but not in DLD-1 cells, where impairment of butyrate oxidation seemed to precede later occurrence of cell damage. TNF-alpha+INF-gamma induced CEC damage was independent on NO formation and involved the IFN-gamma signalling pathway as well as induction of apoptosis. If cytokines have similar effects in vivo, these may lead to energy deficiency and thus contribute to CEC damage and disturbance of the epithelial integrity.
Gold-coated iron nanoparticles (NPs) selectively and significantly (P <0.0001) inhibit proliferation of oral- and colorectal-cancer cells in vitro at doses as low as 5 mg/mL, but have little adverse effect on normal healthy control cells. The particle treatment caused delay in cell-cycle progression, especially in the S-phase. There was no significant difference in the NP uptake between cancer and control cells, and cytotoxicity resulted primarily from the iron core, before oxidation, rather than from the Fe ions released from the core. In contrast with magnetic NPs that usually serve as drug carriers, diagnostic probes or hyperthermia media, the iron, before oxidation, in the NPs selectively suppressed cancer cell growth and left healthy control cells unaffected in vitro and in vivo. This...
Colorectal cancer is the second most common cause of cancer death in the world and about half of the patients with colorectal cancer require adjuvant therapy after surgical resection. Therefore, the eradication of cancer cells via chemotherapy constitutes a viable approach to treating patients with colorectal cancer. In this study, the effects of bufalin isolated from a traditional Chinese medicine were evaluated and characterized in HT-29 and Caco-2 human colon cancer cells. Contrary to its well-documented apoptosis-promoting activity in other cancer cells, bufalin did not cause caspase-dependent cell death in colon cancer cells, as indicated by the absence of significant early apoptosis as well as poly(ADP-ribose) polymerase and caspase-3 cleavage. Instead, bufalin activated an autophagy...
A case (female, 39?years of) of thyroid-like nasopharyngeal low-grade papillary adenocarcinoma with a significant spindle cell component is presented. The tumor was located on the posterior nasal septum. The spindle cells displayed nuclear features very much similar to the epithelial component and the two cell types merged imperceptibly. Immunohistochemically, the neoplastic cells (including the spindle cell component) were strongly and diffusely positive for TTF-1, cytokeratins (AE1-3), cytokeratin 19 and vimentin. C-kit immunohistochemistry showed diffuse mild to moderate membranous positivity with focal areas displaying moderate to strong immunoreactivity. EMA was strongly positive in the epithelial component with membranous and cytoplasmic reactivity whereas the spindle cell component ...
The Interim Examination and Maintenance (IEM) Cell is located within the Fast Flux Test Facility (FFTF) Reactor Containment Building. This cell is a complex vertical hot cell whose purpose is to process reactor experiments and to perform maintenance on reactor and refueling components. Because access to this very complex cell is limited, a mock-up called the IEM Training Facility (IEMTF) has been developed. The IEMTF provides the IEM cell with many valuable benefits. Four of these benefits are: (1) development of alternate processing methods; (2) hands-on evaluation of equipment problems; (3) a ready source of verified parts, and (4) training facilities for IEM Cell technicians.
The influence of low-frequency electromagnetic field irradiating by high-voltage transmission lines on signal transduction of cell in spleen cells of the rates have been studied by molecular-biology techniques. The spleen cells are extracted from skilled rates, which are exposed in the electromagnetic field of high-voltage transmission lines with 4000 V/m and 0.09-0.1 G about 400 days. The quantity or level of phosphorylation of signal transducer and activator of transcription (STAT3) in JAK-STAT signal transduction pathway of spleen cells, which are stimulated and unstimulated by IL-2, respectively, are detected by the immunoblotting and immunobiochemistry. The results show that the expression of phospho-STAT3 in spleen cell stimulated by IL-2 differ not from that in the unstimulated cell. The former is significantly large than the latter. This shows that ...
High-quality solar cells have been fabricated by utilizing localized argon-ion laser decomposition of silver neodecanoate spun onto diffused silicon substrates and subsequent electroplating. Early adhesion problems during electroplating have been carefully studied and finally solved using a novel coating procedure. The laser-metallized solar cells have been characterized using lighted and dark current-voltage measurements and compared with baseline cells metallized using standard photolithographic procedures. Non-AR-coated cell efficiencies ranging from 10 to over 11% have been obtained for the laser-metallized cells, comparable with the best baseline cells. The laser-metallized cells have 30 to 40% lower series resistance than the unsintered baseline cells, indicating that in-situ sintering takes place during laser ...
Reference is made to Cheng and Leblond (Amer. J. Anat.; 141:537 (1974)) who used tritiated thymidine to kill cells synthesising DNA in the crypts of the small intestine. Amongst their findings was that very low doses caused measurable cell killing and that the killing was not random throughout the crypt but occurred selectively at the crypt base where stem cells are presumably located. It is here reported that the presence of hypersensitive cells at the base of the crypts can be demonstrated after whole-body X- or gamma-irradiation, and the time sequence for the production and loss of the killed cells is described together with their dose-response relationship. The studies were conducted on mice. The data were expressed as surviving rather than killed cells, and it was established that the crypt are amongst the most sensitive of mammalian ...
In culture migrating and interacting amoeboid cells can form nematic liquid crystal phases. A polar nematic liquid crystal is formed if the interaction has a polar symmetry. One type of white blood cells (granulocytes) form clusters where the cells are oriented towards the center. The core of such an orientational defect (disclination) is either a granulocyte forced to be in an isotropic state or another cell type like a monocyte. An apolar nematic liquid crystal is formed if the interaction has an apolar symmetry. Different cell types like human melanocytes (=pigment cells of the skin), human fibroblasts (=connective tissue cells), human osteoblasts (=bone cells), human adipocytes (= fat cells) etc., form an apolar nematic liquid crystal. The orientational elastic energy is derived and the ...
Abstract Purpose: To describe the pattern of expression of the cyclin-dependent kinase inhibitors (CDKIs) p16, p21 and p27, and the cell cycle in SRA 01/04 cells relative to contact inhibition. Methods: SRA 01/04 cells were grown to overconfluence under normal conditions. At various phases of the cell growth, cells were assayed by flow cytometry and Western blotting for the expression of CDKIs. Results: Expression of p16 was detected from early logarithmic growth to stationary phases, during which the number of cells in G0/G1 increased from 46 to 69%. Expression of p21 was detected only during the overgrowth phase, when 60% of the cells were in G0/G1. Expression of p27 was not observed in SRA 01/04 cells. Conclusions: p16 expression was likely mediated by G0/G1 arrest to induce contact inh...
A conceptual design of an advanced sodium/sulfur cell for US electric-van applications has been completed. The important design factors included specific physical and electrical requirements, service life, manufacturability, thermal management, and safety. The capacity of this cell is approximately the same as that for the ``PB`` cell being developed by Silent Power Limited (10 Ah). The new cell offers a 50% improvement in energy capacity and nearly a 100% improvement in peak power over the existing PB cells. A battery constructed with such cells would significantly exceed the USABC`s mid-term performance specifications. In addition, a similar cell and battery design effort was completed for an advanced passenger car application. A battery using the van cell would have nearly 3 times the energy compared to lead-acid ...
A review is given of the state-of-the-art of single and polycrystalline solar cells, which includes a short theoretical review, laboratory achievements, and production methods. The Si single and polycrystalline cell and the amorphous Si cell are described, including material preparation, crystal and sheet growth, and cell and panel production. Promising second generation thin film solar cells including GaAs, CdS(CuInSe/sub 2/), and CdTe are briefly described. Economical aspects are discussed.
The possibility of using lead and lead-bismuth mixed oxides as positive active materials in organic electrolyte lithium cells with a working voltage similar to those of silver zinc cells has been considered. Button cells of SR 44 size have been developed as a test vehicle and studied under various conditions of discharge rate and storage. This paper describes the performance characteristics obtained under these conditions and suggests in conclusion the possible replacement of silver zinc cells by such systems for a large range of low-rate applications on the basis of cost effectiveness.
Scientists at JPL have developed chemical and biological techniques using microspheres filled with drugs, electron-opaque metals, or radioactive, fluorescent, magnetic or electrically charged materials to label specific groups of cells. Synthetic polymeric microspheres are coupled with specific antibodies to form reagents called immunomicrospheres, which can seek out and attach themselves to any specific group of cells. These cell-labeling techniques, therefore, open new avenues not only to the basic study of cells but also to the diagnosis and treatment of many diseases, including cancer.
The combination of wood gasification and high temperature fuel cells like solid oxide fuel cells (SOFC) is an interesting approach to achieve high electrical efficiencies (40%) in small scale combined heat and power plants. This combination is called 'Biomass - Integrated Gasification Fuel Cell System' (B-IGFC). The main challenge is the adjustment of the three main components gasification, gas cleaning and fuel cell. In this technology, the first proof of principle by combining a gasifier with a SOFC in a laboratory scale for more than 100 hours was achieved. During this period, no deactivation of the system was found. (author)
The analgesic, dipyrone (1,phenyl-2,3-dimethyl-5-pyrazolone-4-methylamino methane sulphonate sodium), at 20 mM concentration, inhibited the rejoining of single-strand scissions in DNA of Escherichia coli B/r cells induced by 20 krad gamma-radiation. The chemical altered the cell membrane structure as evidenced from the uptake of acriflavin, the efflux of potassium ions from the bacterial cells and the inhibition of alkaline phosphatase-a cell membrane associated enzyme. (author). 18 refs., 6 figures.
The analgesic, dipyrone (1,phenyl-2,3-dimethyl-5-pyrazolone-4-methylamino methane sulphonate sodium), at 20 mM concentration, inhibited the rejoining of single-strand scissions in DNA of Escherichia coli B/r cells induced by 20 krad gamma-radiation. The chemical altered the cell membrane structure as evidenced from the uptake of acriflavin, the efflux of potassium ions from the bacterial cells and the inhibition of alkaline phosphatase-a cell membrane associated enzyme. (author).
Models of the human airways have played a major role in evaluating the health effects of inhaled radionuclides. While models such as those of Weibel (1963) provide data necessary for characterizing deposition of aerosol, they have not characterized the cells at risks in the airspaces. Given the advancements in techniques and study of cell cultures exposed to ionizing radiation there is a need to extrapolate between the simple structures of cell culture systems and the complex architecture of the human airways. The preliminary data in this paper provide a complete characterization of the size and number of cells in the airways and represents a significant advance in our study of the health consequences of exposure to inhaled radionuclides. 26 refs., 2 figs., 4 tabs.
Cell voltage monitoring (CVM) systems are essential for the operation of fuel cell stacks and some battery systems, in the field as well as in the laboratory, because they allow the diagnosis and correction of problems that would otherwise go unnoticed and cause impaired performance or even permanent damage. A robust, safe, and low-cost design for a CVM unit is presented, using electromechanical relays as multiplexing switches. Some examples from the application of the unit on the University of Delaware's fuel cell battery hybrid buses are presented, including its use in automatically correcting anode flooding and diagnosing air channel blockage. (author)
The matter spectrum of the MSSM, including three right-handed neutrino supermultiplets and one pair of Higgs-Higgs conjugate superfields, can be obtained by compactifying the E_{8} x E_{8} heterotic string and M-theory on Calabi-Yau manifolds with specific SU(4) vector bundles. These theories have the standard model gauge group augmented by an additional gauged U(1)_{B-L}. Their minimal content requires that the B-L gauge symmetry be spontaneously broken by a vacuum expectation value of at least one right-handed sneutrino. In previous papers, we presented the results of a quasi-analytic renormalization group analysis showing that B-L gauge symmetry is indeed radiatively broken with an appropriate B-L/electroweak hierarchy. In this paper, we extend these results by 1) enlarging the initial parameter space and 2) explicitly calculating all renormalization group equations numerically, without approximation. The regions of the initial parameter space leading to ...
E8 X E8 heterotic string and M-theory, when appropriately compactified, can give rise to realistic, N=1 supersymmetric particle physics. In particular, the exact matter spectrum of the MSSM, including three right-handed neutrino supermultiplets, one per family, and one pair of Higgs-Higgs conjugate superfields is obtained by compactifying on Calabi-Yau manifolds admitting specific SU(4) vector bundles. These "heterotic standard models" have the SU(3)_{C} X SU(2)_{L} X U(1)_{Y} gauge group of the standard model augmented by an additional gauged U(1)_{B-L}. Their minimal content requires that the B-L gauge symmetry be spontaneously broken by a vacuum expectation value of at least one right-handed sneutrino. In a previous paper, we presented the results of a renormalization group analysis showing that B-L gauge symmetry is indeed radiatively broken with a B-L/electroweak hierarchy of O(10) to O(10^{2}). In this paper, we present the details of that analysis, extending ...
Introduccion y objetivos Aunque los bloqueos de rama (BR) se consideran hallazgos frecuentes, la informacion sobre su prevalencia real en la poblacion general es escasa, y es inexistente en los pacientes en dialisis. El objetivo es establecer la prevalencia del BR completo en la poblacion que inicia dialisis y los factores relacionados con su aparicion. Como analisis adicional, se explora su asociacion con la mortalidad y con la aparicion de un evento cardiovascular. Metodos Se incluyo a los pacientes que iniciaron dialisis en nuestro centro entre el 1 de noviembre de 2003 y el 31 de diciembre de 2006. Todos fueron sometidos a valoracion cardiologica al inicio de dialisis. Determinamos el BR y su relacion con factores clinicos y parametros ecocardiograficos y bioquimicos. Los pacientes fue...
A study has been performed for the development and assessment of a subchannel analysis code which is purposed to be used for the analysis of advanced reactor conditions with various configurations of reactor core and several kinds of reactor coolant fluids. The subchannel analysis code was developed on the basis of MATRA code which is being developed at KAERI. A GUI (Graphic User Interface) system was adopted in order to reduce input error and to enhance user convenience. The subchannel code was complemented in the property calculation modules by including various fluids such as heavy liquid metal, gas, refrigerant,and supercritical water. The subchannel code was applied to calculate the local thermal hydraulic conditions inside the non-square test bundles which was employed for the analysis of CHF. The applicability of the subchannel code was evaluated for a high temperature gas cooled reactor condition and supercritical pressure conditions with water and Freon. A ...
JAERI has been performing transient core thermal-hydraulic test program. In the program, authors performed BWR/ABWR DBE simulation tests with a test facility, which can simulate BWR/ABWR transients. The test facility has a 4 x 4 bundle core simulator with 15-rod heaters and one non-heated rod. Through the tests, authors quantified the thermal safety margin for core cooling. In order to quantify the thermal safety margin, authors collected experimental data on post-CHF. The data are essential for the evaluation of clad temperature transient when core heat-up occurs during DBEs. In comparison with previous post-CHF tests, present experiments were performed in much wider experimental condition, covering high clad temperature, low to high pressure and low to high mass flux. Further, data at wider elevation (lower to higher elevation of core) were obtained in the present experiments, which make possible to discuss the effect of axial position on thermal-hydraulics, ...
Many social Web sites allow users to publish content and annotate with descriptive metadata. In addition to flat tags, some social Web sites have recently began to allow users to organize their content and metadata hierarchically. The social photosharing site Flickr, for example, allows users to group related photos in sets, and related sets in collections. The social bookmarking site Del.icio.us similarly lets users group related tags into bundles. Although the sites themselves don't impose any constraints on how these hierarchies are used, individuals generally use them to capture relationships between concepts, most commonly the broader/narrower relations. Collective annotation of content with hierarchical relations may lead to an emergent classification system, called a folksonomy. While some researchers have explored using tags as evidence for learning folksonomies, we believe that hierarchical relations described above offer a high-quality source of evidence ...
In this study, the adoptable essential technologies and reference design concept of the advanced reactor were developed and related basic experiments were performed. (1) Once-through Helical Steam Generator: a performance analysis computer code for heli-coiled steam generator was developed for thermal sizing of steam generator and determination of thermal-hydraulic parameters. (2) Self-pressurizing pressurizer : a performance analysis computer code for cold pressurizer was developed. (3) Control rod drive mechanism for fine control : type and function were surveyed. (4) CHF in passive PWR condition : development of the prediction model bundle CHF by introducing the correction factor from the data base. (5) Passive cooling concepts for concrete containment systems: development of the PCCS heat transfer coefficient. (6) Steam injector concepts: analysis and experiment were conducted. (7) Fluidic diode concepts : analysis and experiment were conducted. (8) Wet thermal ...
The fuel composition heterogeneity effect on reactor performance parameters was assessed by refueling simulations for three DUPIC fuel options of fuel composition heterogeneity control: the fissile content adjustment, the reactivity control by slightly enriched and depleted uranium, and the reactivity control by natural uranium. For each DUPIC fuel option, the simulations were performed using 30 heterogeneous fuel types which were determined by the agglomerative hierarchical clustering method. The heterogeneity effect was considered during the refueling simulation by randomly selecting fuel types for the refueling operation. The refueling simulations of the heterogeneous core have shown that the key performance parameters such as the maximum channel power (MCP), maximum bundle power (MBP), and channel power peaking factor (CPPF) are close to those of the core that has single fuel type. For the three DUPIC fuel options, the uncertainties of MCP, MBP, and CPPF due to ...
The characterization data obtained to data are described for Approved Testing Material 105 (ATM-105), which is spent fuel from Bundles CZ346 and CZ348 of the Cooper Nuclear Power Plant, a boiling-water reactor. This report is one in a series being prepared by the Materials Characterization Center at Pacific Northwest Laboratory (PNL) on spent fuel ATMs. The ATMs are receiving extensive examinations to provide a source of well-characterized spent fuel for testing in the US Department of Energy Office of Civilian Radioactive Waste Management (OCRWM) Program. ATM-105 consists of 88 full-length irradiated fuel rods with rod-average burnups of about 2400 GJ/kgM (28 MWd/kgM) and expected fission gas release of about 1%. Characterization data include (1) descriptions of as-fabricated fuel design, irradiation history, and subsequent storage and handling; (2) isotopic gamma scans; (3) fission gas analyses; (4) ceramography of the fuel and metallography of the cladding; (5) ...
A small break LOCA event simulation with no high pressure injection system available, known as International Atomic Energy Agency Standard Problem Exercise no. 4 (IAEA-SPE-4), was performed on the PMK-2 integral test facility in Budapest in 1993. This paper analyses the response of the PMK-2 facility, a model of VVER-440 nuclear power plant, using the latest released version MOD3.2.1.2 of the RELAP5 thermal-hydraulic code. After several years of the SPE-4 experiment analyses, many problems have emerged and been studied. Main goal of the present analyses was to study the main influencing parameters for adequate modelling of the hexagonal core channel with 19-rod bundle and phenomena during the core uncovery. Some influencing parameters have been identified, mostly on the primary side, but some also on the secondary side. This is exact simulation of main coolant pump coast down, hydro-accumulators water temperature and connections to the primary system. Some concern ...
Youngkwang Unit 3,4 and Ulchin Unit 3 and 4 have had problem of the KSNP Steam Generator due to a severe fretting wear on the tube. In particular, the wears were localized and concentrated in the upper part of U-bend of the Central Cavity region. At the upper tube bundle Central Cavity, the fluid flow velocities and void fraction are very high, because the steam is made by high heat transfer at secondary region. Also, this region is affected easily by fretting wear due to it's unsupported span is longer than another regions. The fretting wear is assumed to be result of Flow-Induced Vibration (F. I. V), which can occur by many mechanisms. EFDP was added to UCN 5,6 for prevent fretting wear by the SEC LCC and DSHIC, a company of design and manufacture of the steam generator, respectively. In order to evaluate the efficacy of EFDP, ANSYS and ATHOS-3 Code were used. From sensitivity analysis and calculation results, Density and Velocity into the Central Cavity ...
Youngkwang Unit 3,4 and Ulchin Unit 3 and 4 have had problem of the KSNP Steam Generator due to a severe fretting wear on the tube. In particular, the wears were localized and concentrated in the upper part of U-bend of the Central Cavity region. At the upper tube bundle Central Cavity, the fluid flow velocities and void fraction are very high, because the steam is made by high heat transfer at secondary region. Also, this region is affected easily by fretting wear due to it's unsupported span is longer than another regions. The fretting wear is assumed to be result of Flow-Induced Vibration (F. I. V), which can occur by many mechanisms. EFDP was added to UCN 5,6 for prevent fretting wear by the SEC LCC and DSHIC, a company of design and manufacture of the steam generator, respectively. In order to evaluate the efficacy of EFDP, ANSYS and ATHOS-3 Code were used. From sensitivity analysis and calculation results, Density and Velocity into the Central Cavity are ...
All gauge theories need ``something fixed'' even as ``something changes.'' Underlying the implementation of these ideas all major physical theories make indispensable use of an elaborately designed spacetime model as the ``something fixed,'' i.e., absolute. This model must provide at least the following sequence of structures: point set, topological space, smooth manifold, geometric manifold, base for various bundles. The ``fine structure'' of spacetime inherent in this sequence is of course empirically unobservable directly, certainly when quantum mechanics is taken into account. This issue is at the basis of the difficulties in quantizing general relativity and has been approached in many different ways. Here we review an approach taking into account the non-Boolean properties of quantum logic when forming a spacetime model. Finally, we recall how the fundamental gauge of diffeomorphisms (the issue of general covariance vs coordinate conditions) raised deep ...