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Objectives: Human influenza A (H1N1) 2009 has caused severe epidemics in many countries, but its dynamics in spatial and temporal contexts have so far been poorly appreciated. Methods: A total of 24,414 laboratory confirmed human influenza A (H1N1) 2009 cases reported from May to September 2009 in Hong Kong were evaluated, using a Geographic Information System (GIS)-based approach. Spatio-temporal clustering was assessed after dividing Hong Kong into 4 geographic sectors, 18 districts and 500 m x 500 m cells. Global Moran's I, Local Moran's I and SaTScan(TM) were used in the exploration. Results: Spatio-temporal clusters first appeared on Hong Kong Island at week 3, alongside multiple foci suggestive of infection nidus introduced from abroad. The clusters grew rapidly and became confluent ...

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BackgroundUnderstanding immunity, incidence and risk factors of the 2009 influenza A(H1N1) pandemic (2009 H1N1) through a national seroprevalence study is necessary for informing...Full Text Available

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The first candidate rotavirus vaccine was a live attenuated oral vaccine made by the classical empirical method of serial passage of virus in tissue culture cells. Current tetravalent vaccine candidates that are in the final stages of efficacy testing in the United States were made by genetic reassortment. This article briefly highlights how advances in the basic understanding of the molecular biology of rotaviruses have facilitated vaccine development. New approaches for second-generation vaccines and improvements in vaccine efficacy based on further exploitation of the tools and knowledge of rotavirus molecular biology and pathogenesis are discussed. PMID:8752289

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BACKGROUND: Although the effectiveness of influenza vaccination in high-risk groups has been proven, vaccine coverage continues to be less than 50% in The Netherlands. To improve vaccination rates,...Full Text Available

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... H1N1 a pandemic virus in June 2009, the Defense Advanced Research Projects Agency had a plan to address the crisis. The DARPA effort, called ...

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... Weiss, S., D. Kobiler, H. Levy, H. Marcus, A. Pass, N. Rothschild, and Z ... of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits ...

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in cash and is featured on national television. Congratulations to Dr. John Clarke of Baldwin, New York for his video entitled H1N1 Rap by Dr. Clarke. Congrats to the Winning...

British Library Electronic Table of Contents (United Kingdom)

Introduction: Tumor-derived heat shock protein (HSP)-peptide complexes (HSPPCs) induced immunity against malignancies in preclinical trials, working across tumor types and bypassing the need to identify single immunogenic peptides. These results paved the way for the use of human gp96 obtained from autologous tumor samples as an anti-cancer vaccine. Areas covered: Autologous tumor-derived HSP gp96 peptide complex (HSPPC-96) vaccine is emerging as a tumor- and patient-specific cancer vaccine, with confirmed activity in several malignancies. It has been tested in Phase III clinical trials in advanced melanoma and kidney cancer with evidence for efficacy in patients with earlier stage disease. HSPPC-96-based vaccine demonstrated an excellent safety profile, thus emerging as a novel therapeuti...

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Adenovirus vaccine vectors derived from rare human serotypes have been shown to be less potent than serotype 5 (Ad5) at inducing immune responses to encoded antigens. To identify highly immunogenic...Full Text Available

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Udgivelsesdato: 2002-Mar

British Library Electronic Table of Contents (United Kingdom)

Oral vaccination is the most desirable immunization method by which to prevent fish disease occurring at the early larval stage. We developed an Escherichia coli-based oral nervous necrosis virus (NNV) subunit vaccine and demonstrated its effectiveness in orange spotted grouper (Epinephelus coioides) fry. However, the incubation period was determined to be over 2weeks. To enhance the efficacy and shorten the incubation period, a safe and digestible biological adjuvant should be found. Vibrio anguillarum, a common marine bacterium with immune-stimulatory capability was selected as an expression host. An expression vector containing its heat shock protein 60 gene (groE) as an inducible promoter was constructed to express recombinant NNV coat protein as an antigen. The recombinant V. anguilla...

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Correlates between immunological parameters and protection against Bacillus anthracis infection in animals vaccinated with protective antigen (PA)-based vaccines could provide surrogate markers to evaluate the putative protective efficiency of immunization in humans. In previous studies we demonstrated that neutralizing antibody levels serve as correlates for protection in guinea pigs (S. Reuveny et al., Infect. Immun. 69:2888-2893, 2001; H. Marcus et al., Infect. Immun. 72:3471-3477, 2004). In this study we evaluated similar correlates for protection by active and passive immunization of New Zealand White rabbits. Full immunization and partial immunization were achieved by single and multiple injections of standard and diluted doses of a PA-based vaccine. Passive immunization was carried out by injection of immune sera from rabbits vaccinated with ...

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Twenty autopsy cases with 2009 pandemic influenza A (2009 H1N1) virus infection, performed between August 2009 and February 2010, were histopathologically analyzed. Hematoxylin-eosin staining, immunohistochemistry for type A influenza nucleoprotein antigen, and real-time reverse transcription-PCR assay for viral RNA were performed on formalin-fixed and paraffin-embedded specimens. In addition, the D222G amino acid substitution in influenza virus hemagglutinin, which binds to specific cell receptors, was analyzed in formalin-fixed and paraffin-embedded trachea and lung sections by direct sequencing of PCR-amplified products. There were several histopathological patterns in the lung according to the most remarkable findings in each case: acute diffuse alveolar damage (DAD) with a hyaline membrane (four cases), organized DAD (one case), acute massive intra-alveolar edema with variable degrees of hemorrhage ...

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PMID:7483502

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home when you are sick helps everyone you care about Questions & Answers Flu Vaccine: Q&A Vaccine Dosage & Administration Vaccine Supply for 2011-12 Season Vaccine Supply and...

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Data from 52 litters farrowed in two seasons of a cross-fostering experiment were analyzed to estimate variances and covariances for additive direct and maternal genetic effects on immune response to pseudorabies virus and B. bronchiseptica vaccine. Twenty purebred boars and 44 sows of the Duroc, Landrace and Yorkshire breeds were used. Immune response was measured after vaccine challenge. A modified-live pseudorabies (PR) vaccine was administered to piglets at 28 d of age; response was measured by log2 serum neutralization titers at 56 d. An inactivated B. bronchiseptica bacterin was administered at 28, 42 and 112 d. Antibody levels were measured relative to positive and negative controls at 28, 56 and 119 d by using an enzyme-linked immunosorbent assay (ELISA). Results from this study for heritability were .18 +/- .09 for PR titer and .15 +/- .07 and .52 +/- .15 for 56- and 119-d ELISA values, respectively. The ...

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Based on studies on the genetic and molecular basis of Shigella flexneri invasive properties, we have constructed and evaluated a double mutant of S. flexneri serotype 5 for utilization as a live attenuated oral vaccine against shigellosis. The first mutation, icsA, blocks intracellular spread of bacteria as well as cell-to-cell infection. It affects the capacity of the invasive pathogen to form large abscesses in epithelia. The second mutation, iuc, eliminates production of the siderophore aerobactin thus impairing growth of the bacterium within tissues. This double mutant, SC5700 appeared safe when administered intragastrically to macaque monkeys as three doses (5 x 10(10) c.f.u. each) at weekly intervals. Protection against a challenge by the wild type isolate (M90T) was observed 4 weeks after the last vaccine inoculation. Duration of carriage was considerably reduced as compared to the control group in which all animals ...

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A recent clinical trial of a T-cell-based AIDS vaccine delivered with recombinant adenovirus type 5 (rAd5) vectors showed no efficacy in lowering viral load and was associated with increased risk of...Full Text Available

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Ninety percent of foxes fed commercial ERA vaccine in a specially designed bait developed rabies serum neutralizing antibodies. The vaccine bait did not cause clinical signs of rabies when consumed...Full Text Available

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The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design....Full Text Available

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Abstract Development of inhibitors and vaccines that mitigate rumen-derived methane by targeting methanogens relies on knowledge of the methanogens present. We investigated the composition of archaeal communities in the rumens of farmed sheep (Ovis aries), cattle (Bos taurus) and red deer (Cervus elaphus) using denaturing gradient gel electrophoresis (DGGE) to generate fingerprints of archaeal 16S rRNA genes. The total archaeal communities were relatively constant across species and diets, and were less variable and less diverse than bacterial communities. There were diet- and ruminant-species-based differences in archaeal community structure, but the same dominant archaea were present in all rumens. These were members of three coherent clades: species related to Methanobrevibacter ruminan...

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There is a quest for the development of a new generation of vaccines consisting of well-defined subunit antigens. For a number of practical reasons it is attractive to develop vaccines on the basis...Full Text Available

UK PubMed Central (United Kingdom)

The development of an HIV vaccine will require a more precise understanding of the immunological and virological underpinnings of HIV infection. Magnetofection, the process of magnetizing HIV...Full Text Available

UK PubMed Central (United Kingdom)

The attitude of Nigerian mothers, mainly Yoruba, towards measles vaccine and other aspects of prevention are influenced by different perceptions of the cause of measles. There is a significant correlation...Full Text Available

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BackgroundAlthough the World Health Organization had recommended that every child be vaccinated for Hepatitis B by the early 1980s, large multinational pharmaceutical companies held...Full Text Available

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Splenectomy or pretreatment of adult hamsters with cyclophosphamide (Cytoxan) increased the lethality of the TC-83 vaccine strain of Venezuelan encephalitis virus (VEE), inoculated subcutaneously, from 12% for normal hamsters to 75 and 76% respectively. A...

UK PubMed Central (United Kingdom)

We studied the effect of booster injections and the long-term immune response after injections of an anti-human immunodeficiency virus type 1 (HIV-1) lipopeptide vaccine. This vaccine was injected alone...Full Text Available

DEFF Research Database (Denmark)

OBJECTIVES: The authors examine the rationale and efficacy of pre-travel hepatitis B immunization strategies based on itinerary and presumed on-travel risk behaviour. METHODS: A large survey among 26,640 Danes survey provided data on journey lengths and destinations, immunization coverage, risk behaviour and knowledge. RESULTS: The estimated cumulative lifetime stay in endemic areas outside Europe is 4.3 months. The majority of risk situations are involuntary and unforeseeable. The majority of risk situations occur on short-term journeys. 5% nonimmune and 5% short-term travellers experienced at least one risk situation such as injections/operations/tattoos on their journey. The level of knowledge of hepatitis A and B is low. CONCLUSIONS: The rationale and efficacy of current immunization strategies are challenged. Based on the results presented here and the availability of vaccines with long-lasting coverage, the authors ...

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IntroductionThe outbreak of cholera in Zimbabwe intensified interest in the control and prevention of cholera. While there is agreement that safe water, sanitation, and personal...Full Text Available

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Enter Search terms A-Z Index Home Food Drugs Medical Devices Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Radiation-Emitting Products Tobacco ...

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A letter of inquiry was sent to 21 countries in Europe to ascertain their experience of diphtheria during the last 20 years. An analysis of the 15 replies showed that all relied on childhood vaccination...Full Text Available

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... view on the utility of such attacks, see JH Rothschild, Tomorrow's Weapons ... Aum Shinrikyo may have had a stolen vaccine anthrax strain incapable ...

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BackgroundMycobacterium avium subspecies paratuberculosis causes systemic infection and chronic intestinal inflammation in many species including...Full Text Available

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Vibrio cholerae 638 (El Tor, Ogawa), a new CTXΦ-negative hemagglutinin/protease-defective strain that is a cholera vaccine candidate, was examined for safety and immunogenicity...Full Text Available

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The use of tick vaccines in mammalian hosts has been shown to be the most promising alternative tick control method to current use of acaricides, which suffers from a number of limitations. However,...Full Text Available

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Veterinarians and farmers employing multivalent killed vaccines in lactating dairy cows have reported transient losses in milk production. Few studies have quantified this loss. In this report, effects...Full Text Available

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BackgroundThe malaria vaccine candidate antigen RTS,S includes parts of the pre-erythrocytic stage circumsporozoite protein fused to the Hepatitis B surface antigen. Two Adjuvant...Full Text Available

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In this paper we present an overview of the literature on efficacy and safety trials of the various pneumococcal conjugate vaccines on the market (PCV7) and in development (PCV9, PCV11 and allegedly PCV10 and PCV13), as well as of observations from post-licensure studies. Seven- (PCV7) and nine-valent PCV (PCV9) are reported to be sufficiently immunogenic after administration of a 3+1 schedule in infants in various RCTs. PncOMPC (PCV7 with a protein of N. meningitidis as a carrier) is less immunogenic, though this may have no repercussions for the protective efficacy against clinical disease. PCV7 is 82-97% efficacious against vaccine serotype (VT) IPD, 90% efficacious against (clinically diagnosed) pneumococcal pneumonia, and, like the 11-valent PCV, 57% efficacious against VT acute otiti...

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The trematode Fasciola hepatica (Fa.he.) is a common parasite of human and livestock. The hemoglobin (Hb) of Fa.he., a potential immunogen, was chosen for characterization...Full Text Available

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AbstractIndividual informed consent is a key ethical obligation for clinical studies, but empirical studies show that key requirements are often not met. Common recommendations to strengthen...Full Text Available

UK PubMed Central (United Kingdom)

Genetically identical rhesus monkeys would have tremendous utility as models for the study of human disease and would be particularly valuable for vaccine trials and tissue transplantation studies where...Full Text Available

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A preventive medicine program of rubella control for trainees at the Air Force Military Training Center, Lackland AFB, Texas, was begun in October 1977. Incoming trainees were screened for rubella susceptibility,...Full Text Available

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A prospective cohort study was undertaken in two commercial California dairies. The treatment group, 246 cows, received three doses of a whole cell bacterin of J5 Escherichia coli (mutant of E. coli...Full Text Available

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Israel has faced the challenge presented by epidemic poliomyelitis by using different immunization strategies. In the 1950s, inactivated poliovirus vaccine (IPV) helped to reduce the total burden of...Full Text Available

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Cholera vaccine candidate Peru-15 was derived from a Vibrio cholerae O1 El Tor Inaba strain by deleting the cholera toxin genetic element, introducing the gene encoding cholera toxin B subunit into recA, and screening for nonmotility. In a controlled study, Peru-15 (2 x 10(8) cfu) was administered to 11 volunteers. No vaccinee developed diarrhea, and 10 of 11 had > 4-fold rises in vibriocidal antibody titers. One month later, 5 vaccinees and 5 control volunteers were challenged with wild type V. cholerae O1. Four of 5 controls developed diarrhea (mean, 1.9 L). Two Peru-15 vaccinees developed diarrhea, 1 with < 0.3 L and 1 with approximately 1.0 L; this latter volunteer had not developed a significant vibriocidal immune response to vaccination. Peru-15 shows promise as a single-dose, oral cholera vaccine that is safe, immunogenic, and protective. PMID:7561195

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Antibodies against feline leukemia virus (FeLV) and the feline oncornavirus-associated cell membrane antigen (FOCMA) were transferred from pregnant cats to their suckling kittens. All of these kittens...Full Text Available

UK PubMed Central (United Kingdom)

In this report we define the parameters of the human immune response after immunization with hepatitis B vaccine. 2 wk after booster immunization, there is significant spontaneous secretion of antibody...Full Text Available

UK PubMed Central (United Kingdom)

Increasing numbers of human cowpox virus infections that are being observed and that particularly affect young non-vaccinated persons have renewed interest in this zoonotic disease. Usually causing...Full Text Available

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Evaluation of the protective efficacy of recombinant T-cell-reactive proteins of Coccidioides posadasii in a murine model of coccidioidomycosis has led to the discovery of potential...Full Text Available

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Definition of the T-lymphocyte responses to dengue viruses should aid in the development of safe and effective vaccines and help to explain the pathophysiology of dengue hemorrhagic fever and dengue...Full Text Available

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Effectiveness Flu Shot Nasal Spray Vaccine (LAIV) Thimerosal Guillain-Barré Syndrome (GBS) Antiviral Drugs: Key Facts Antiviral Drugs: Q&A Antiviral Drug Resistance Links,...

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Public health activities, especially infectious disease control, depend on effective teamwork. We present the results of a pilot audit questionnaire aimed at assessing the quality of public health services...Full Text Available

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In this paper we present an overview of the literature on efficacy and safety trials of the various pneumococcal conjugate vaccines on the market (PCV7) and in development (PCV9, PCV11 and allegedly PCV10 and PCV13), as well as of observations from post-licensure studies. Seven- (PCV7) and nine-valent PCV (PCV9) are reported to be sufficiently immunogenic after administration of a 3+1 schedule in infants in various RCTs. PncOMPC (PCV7 with a protein of N. meningitidis as a carrier) is less immunogenic, though this may have no repercussions for the protective efficacy against clinical disease. PCV7 is 82-97% efficacious against vaccine serotype (VT) IPD, 90% efficacious against (clinically diagnosed) pneumococcal pneumonia, and, like the 11-valent PCV, 57% efficacious against VT acute otitis media. Naturally, it would be of paramount public health interest if the same levels of efficacy and effectiveness could be achieved with fewer doses. ...

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European sea bass (Dicentrarchus labrax L.) is a marine species of great economic importance, particularly in Mediterranean aquaculture. However, numerous pathogenic viruses, bacteria, fungi and parasites affect the species, causing various infectious diseases and thereby leading to the most heavy losses in aquaculture production of sea bass. In this respect, knowledge on molecular and genetic mechanisms of resistance to pathogens and specific features of immune response against various infectious agents should greatly benefit the development of effective vaccines and proper vaccination strategies in marker-assisted selection of fish resistant to a range of infections. To date, genetic knowledge on sea bass immune regulatory genes responsible for resistance to pathogens is relatively poor ...

UK PubMed Central (United Kingdom)

Hepatitis B subviral particles, purified from plasma of asymptomatic carriers seropositive for hepatitis B e antigen, were treated with various conditions reported for the processing of vaccines. Thereafter,...Full Text Available

UK PubMed Central (United Kingdom)

The ERA strain of rabies virus was propagated in a baby hamster kidney cell line (BHK-21/C13). The viral titer was 10(1.8) tissue culture infective doses (TCID) higher than that of commercial ERA vaccine....Full Text Available

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Two plasmids which express either nearly intact or truncated filamentous hemagglutinin (FHA) from Bordetella pertussis and which are marked with a tetracycline resistance (Tcr) gene were transformed into Salmonella dublin SL1438, an aroA deletion mutant intended for use as an attenuated oral vaccine against salmonellosis. These S. dublin recombinants, when fed to mice, induced serum immunoglobulin, immunoglobulin M (IgM), and sometimes IgA antibody responses to FHA and S. dublin. In addition, IgA antibodies against FHA were found in gut wash fluids. S. dublin carrying pDB2300, a multicopy plasmid encoding truncated FHA protein, induced a better antibody response than did S. dublin carrying pDB2000, a low-copy-number plasmid encoding full-sized FHA. Administration of tetracycline to mice enhanced the stability of recombinant plasmids, and tetracycline-treated mice developed higher anti-FHA titers. Although neither strain examined is suitable for use in a human oral ...

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BackgroundAfrican horse sickness virus (AHSV) causes a non-contagious, infectious disease in equids, with mortality rates that can exceed 90% in susceptible horse populations....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

In order to conserve vaccines in hot countries a solar refrigerator has been made by a French university. It is a photothermal refrigerator without batteries. It uses two gases: ammonia and calcium chloride. The refrigerator is autonomous and can work eleven days without sun. (N.C.)

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Marburg virus belongs to the genus Marburgvirus in the family Filoviridae and causes a severe hemorrhagic fever, known as Marburg hemorrhagic fever (MHF), in both humans and nonhuman primates. Similar to the more widely known Ebola hemorrhagic fever, MHF is characterized by systemic viral replication, immunosuppression and abnormal inflammatory responses. These pathological features of the disease contribute to a number of systemic dysfunctions including hemorrhages, edema, coagulation abnormalities and, ultimately, multiorgan failure and shock, often resulting in death. A detailed understanding of the pathological processes that lead to this devastating disease remains elusive, a fact that contributes to the lack of licensed vaccines or effective therapeutics. This article will review the...

CERN Document Server

Selected applications of novel techniques in Agricultural Biotechnology, Health Food formulations and Medical Biotechnology are being reviewed with the aim of unraveling future developments and policy changes that are likely to open new markets for Biotechnology and prevent the shrinking or closing of existing ones. Amongst the selected novel techniques with applications in both Agricultural and Medical Biotechnology are: immobilized bacterial cells and enzymes, microencapsulation and liposome production, genetic manipulation of microorganisms, development of novel vaccines from plants, epigenomics of mammalian cells and organisms, and biocomputational tools for molecular modeling related to disease and Bioinformatics. Both fundamental and applied aspects of the emerging new techniques are being discussed in relation to their anticipated, marked impact on future markets and present policy changes that are needed for success in either Agricultural or Medical ...

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Mycoplasma ovipneumoniae is associated with chronic non-progressive pneumonia of sheep and goats. As with many other mycoplasmas involved in animal diseases, protective immune responses have not been achieved with vaccines, even though antibody responses can be obtained. This study focuses on characterizing the interaction of M. ovipneumoniae with ovine PBMC using carboxy-fluorescein-succinimidyl-ester (CFSE) loading and flow cytometry to measure lymphoid cell division. M. ovipneumoniae induced a strong in vitro polyclonal suppression of CD4^+, CD8^+, and B blood lymphocyte subsets. The suppressive activity could be destroyed by heating to 60^oC, and partially impaired by formalin and binary ethyleneimine treatment that abolished its viability. The activity resided on the surface-exposed m...

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Brucella melitensis is a Gram-negative coccobacillus bacteria belonging to the Alphaproteobacteria subclass. It is an important zoonotic pathogen that causes brucellosis, a disease affecting sheep, cattle, and sometimes humans. The B. melitensis strain M5-90, a live attenuated vaccine cultured from the B. melitensis virulent strain M28, has been an effective tool to control brucellosis in goats and sheep in China. Here we report the complete genome sequences of B. melitensis M28 and M5-90, strains with different virulence backgrounds, which will serve as a valuable reference for future studies. PMID:21478357

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Summary The antigenic relationship between the phocine distemper virus (PDV) strain causing the epidemic in 2002 and the PDV strain of 1988, canine distemper virus from two dogs and one marten, and one measles virus strain was investigated in vivo and in vitro using monospecific polyclonal and monoclonal antibodies directed against five different proteins of canine or phocine distemper virus (N, P, M, F, H). Epitopic mapping revealed no difference between the PDV strains causing the epidemics in 1988 or 2002. However, the use of these antibodies allowed discrimination between different morbilliviruses including a vaccine strain of canine distemper virus. The major differences among the investigated morbilliviruses were found in the H protein.

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A rickettsia related to but distinct from the spotted fever agent, Rickettsia rickettsii, has been detected in 167 (18.9%) of 884 Rhipicephalus sanguineus taken off dogs in central and northern Mississippi. The organisms could readily be isolated in male meadow voles (Microtus pennsylvanicus), where it produced massive infections in the tissues of tunica vaginalis. It was practically nonpathogenic for male guinea pigs, although inoculation of these animals with infected tunica vaginalis of voles afforded in 30 of 38 instances solid immunity to challenge with virulent R. rickettsii. The Rhipicephalus rickettsia grew well in monolayers of chicken embryo fibroblast, Vero, mouse L, and HeLa cells. Cytopathogenic effects were minimal unless large concentrations of rickettsiae were used as inocula. It also could be established in embryonated hen eggs but only after injection of massive doses of L cell-propagated organisms. Serological tests (complement fixation, microagglutination and/or ...

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Xenotropic murine leukemia virus-related virus (XMRV) was discovered in human prostate tumors and later in some chronic fatigue syndrome (CFS) patients. However, subsequent studies have identified various sources of potential contamination with XMRV and other murine leukemia virus (MLV)-related sequences in test samples. Biological and nucleotide sequence analysis indicates that XMRV is distinct from known xenotropic MLVs and has a broad host range and cell tropism including human cells. Therefore, it is prudent to minimize the risk of human exposure to infection by evaluating XMRV contamination in cell lines handled in laboratory research and particularly those used in the manufacture of biological products. Nested DNA PCR assays were optimized for investigating XMRV gag and env sequences in various cell lines, which included MRC-5, Vero, HEK-293, MDCK, HeLa, and A549, that may be used in the development of some vaccines and other cell lines broadly used in ...

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Hematopoietic stem cells (HSCs) have remained at the forefront of stem cell research for the past 50 years, since the therapeutic potential of bone marrow transplantation was realized. Uniquely, among stem and progenitor cells, research progress has been made in parallel between the laboratory benchtop and hospital bedside during this period. Integral to this work has been the role of the transfusion medicine services in the collection, storage, and processing of HSCs. The next decade promises to bring further developments: with new fields of cellular therapies, stem cell vaccination, and stem cell drug testing opening up. This article summarizes exciting areas of research concerning the behavior and potential clinical applications of HSCs. For the purposes of clarity, we describe in turn the trafficking and transfer of HSCs; ex vivo expansion of HSC units from different sources; and finally, applications of specifically selected subsets of hematopoietic cells and ...

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Summary Background Treatment of localised renal cell carcinoma consists of partial or radical nephrectomy. A substantial proportion of patients are at risk for recurrence because no effective adjuvant therapy exists. We investigated the use of an autologous, tumour-derived heat-shock protein (glycoprotein 96)-peptide complex (HSPPC-96; vitespen) as adjuvant treatment in patients at high risk of recurrence after resection of locally advanced renal cell carcinoma. Methods In this open-label trial, patients were randomly assigned to receive either vitespen (n=409) or observation alone (n=409) after nephrectomy. Randomisation was done in a one to one ratio by a computer-generated pseudo-random number generator, with a block size of four, and was stratified by performance score, lymph node stat...

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The costs of establishing a computer-based training program for FFTF reactor operators are analyzed.

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... Notes Papers from the Proceedings AIAA 2nd Biennial ... Based (GB) Lower Tier Weapon System clearly ... are too short for space-based cueing to be ...

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Dec 15, 2010 ... If applicable to the agreement, that the market based pricing ...... reduce the price in order to comply with market-based pricing, ...

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... Possessing the unique perspective of space, space-based weapons can immediately ... A weapon system with enough space-based platforms at ...

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However, market based pricing does not apply where the pricing requirements for specific services or .... Market based pricing only applies to the extent ...

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... testing and deployment of space-based, sea-based ... recognized as nuclear weapon possessors by ... possess significant nuclear weapons capabilities ...

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We address the problem of propositional logic-based abduction, i.e., the problem of searching for a best explanation for a given propositional observation according to a given propositional knowledge base. We give a general algorithm, based on the notion of projection; then we study restrictions over the representations of the knowledge base and of the query, and find new polynomial classes of abduction problems.

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Voxel-based prescriptions of deliberately non-uniform dose distributions based on molecular imaging, so-called dose painting or theragnostic radiation therapy, require specification of a transformation...Full Text Available

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We present a methodology and database mediator tool for integrating modern knowledge-based systems, such as the Stanford EON architecture for automated guideline-based decision-support, with legacy...Full Text Available

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New habitat-based models for spread of hantavirus are developed which account for interspecies interaction. Existing habitat-based models do not consider interspecies pathogen transmission,...Full Text Available

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... detonation velocity of single base and double base propellants is investigated using two types ofignititor; an exploding bridgewire detonator with C4 ...

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Naval Submarine Base, Bangor (Bangor) is located on the Kitsap Peninsula along the east shore of Hood Canal in ... ...

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PROPOSAL NUMBER: 04 B3.09-7744. SUBTOPIC TITLE: Radiation Shielding to Protect Humans. PROPOSAL TITLE: Multifunctional, Boron-Foam Based ...

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... Accession Number : ADA089146. Title : Flue Gas Desulfurization at Navy Bases, Navy Energy Guidance Study. Phase IV. ...

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market is addressed through a move to a recycling-led area-based franchise model. ...market is addressed through a move to a recycling-led area-based franchise model.

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Pages 184-197: Understanding Personal Change in a Women’s Faith-Based Transitional Center/title link ...titleUnderstanding Personal Change in a Women’s Faith-Based Transitional Center/dc:title

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In this study, for the institutionalization of risk informed and performance based regulation in Korea, the latest technical movements of overseas countries are examined and reviewed. And the issues that was found when license change petition using risk information was submitted in Korean regulatory body are reviewed. Based on these review, the applicable areas to domestic situation will be found and proposed. This study can contribute to setting up the proper direction for the institutionalization of risk informed and performance based regulation.

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PMID:19395606

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... Figure 4. Production Flowsheets based on Purification of Yellow Cake

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Science.gov (United States)

A computer program entitled "Marshall Aerospace Vehicle Representation in C II,

J-STORE (Japan)

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Science.gov (United States)

... BAE Systems Advanced Information Technologies, Inc. APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. ...

International Science & Technology Center (ISTC)

Characterization and Testing of Coated Nickel- and Iron-Based Superalloys for Application in High-Temperature Power Installations

Science.gov (United States)

PMID:19208697

Energy Technology Data Exchange (ETDEWEB)

Nineteen presentation summaries in this meeting proceedings are individually title listed. (LEW)

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared

Science.gov (United States)

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British Library Electronic Table of Contents (United Kingdom)

A government would like to subsidize an indivisible good. Consumers? valuations of the good vary according to their wealth and benefits from the good. A subsidy scheme may be based on consumers? wealth or benefit information. We translate a wealth-based policy to a benefit-based policy, and vice versa, and give a necessary and sufficient condition for the pair of policies to implement the same assignment: consumers choose to purchase the good under the wealth-based policy if and only if they choose to do so under the translated benefit-based policy. General taxation allows equivalent policies to require the same budget.

CERN Document Server

Graphical Business Process Modelling Languages (BPML) like Role Activity Diagrams (RAD) provide ease and flexibility for modelling business behaviour. However, these languages show limited applicability in terms of enactment over distributed systems paradigms like Service Oriented Architecture (SOA) based grid computing. This paper investigates RAD modelling of a Scientific Publishing Process (SPP) for Digital Libraries (DL) and tries to determine the suitability of Pi-Calculus based formal approaches to enact SOA based grid computing. In order to achieve this purpose, the Pi-Calculus based formal transformation from a RAD model of SPP for DL draws attention towards a number of challenging issues including issues that require particular design considerations for appropriate enactment in a SOA based grid system.

UK PubMed Central (United Kingdom)

The development of the Java Programming Language by Sun Microsystems has provided a new tool for the development of Internet based applications. Our preliminary work has shown how Java can be used to...Full Text Available

UK PubMed Central (United Kingdom)

Using observational and interview approaches, we evaluated the usability of a web-based communication tool that allows managers to announce open work shifts and staff to request work shifts....Full Text Available

UK PubMed Central (United Kingdom)

Sequence-directed variations in the canonical DNA double helix structure that retain Watson-Crick base-pairing play important roles in DNA recognition, topology, and nucleosome positioning....Full Text Available

UK PubMed Central (United Kingdom)

Many simulation studies in biomedicine are based on a similar sequence of processing steps, starting from images and running through geometric model generation, assignment of tissue properties, numerical...Full Text Available

UK PubMed Central (United Kingdom)

ObjectiveThis study assessed the relationship between multiple indicators of ‘real-world’ functioning and scores on a brief performance-based measure...Full Text Available

International Nuclear Information System (INIS)

Progress in the development of negative ion sources and their application in fusion research is reviewed. (U.K.).

Science.gov (United States)

Mar 1, 2004 ... For a summary of papers from a 4-day AIAA conference held February ... m is less than $400 million, with both ground-based and space-based options possible. .... from concerns about a new generation of nuclear weapons. ...

UK PubMed Central (United Kingdom)

Hospitals as research environments are crucial in advancing evidence-based practice and translational research. The authors discuss issues related to hospital-based nursing research such as...Full Text Available

UK PubMed Central (United Kingdom)

We describe an Ebolavirus minigenome-based system that is suitable for high-throughput screening of compounds able to impair Ebolavirus virus replication and/or transcription....Full Text Available

UK PubMed Central (United Kingdom)

The Clinical Summary is a Web-based application for accessing the clinical database at the Massachusetts General Hospital. The application has been developed to give physicians in our health care community...Full Text Available

UK PubMed Central (United Kingdom)

This paper presents HEARTVIEW - a knowledge base (KB) that offers aid for clinical research in cardiology. This KB is an essential component of the medical workstation MW2000, now under development...Full Text Available

UK PubMed Central (United Kingdom)

Several drugs are available for the management of postmenopausal osteoporosis. This may, in daily practice, confuse the clinician. This manuscript offers an evidence-based update of previous treatment...Full Text Available

UK PubMed Central (United Kingdom)

PURPOSE We wanted to assess computer capabilities in a primary care practice-based research network and to understand how receptive the practices were to new ideas for automation of practice...Full Text Available

UK PubMed Central (United Kingdom)

The cyclohexane-1,2-diamine-based bisbinaphthyl macrocycles (S)-/(R)-5 and their cyclic and acyclic analogs are synthesized. The interactions of...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundLittle is known about differences in professional care seeking based on marital status. The few existing studies show more professional care seeking among the divorced...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The applicability of two nuclear analytical methods: radionuclide X-ray fluorescence analysis and radiometric titrations based on precipitate formations was studied in order to determine the heptacaine hydrochloride in solutions. The applied methods were evaluated based on the obtained sensitivity values.

UK PubMed Central (United Kingdom)

The syntheses and applications of two metallointercalators, Rh(bpy)₂(chrysi)³⁺ and Rh(bpy)₂(phzi)³⁺, that target single base mismatches in DNA are...Full Text Available

UK PubMed Central (United Kingdom)

Parallel imaging reconstructions result in spatially varying noise amplification characterized by the g-factor, precluding conventional measurements of noise from the final...Full Text Available

UK PubMed Central (United Kingdom)

There is limited information about the true incidence of acute renal failure (ARF). Most studies could not quantify disease frequency in the general population as they are hospital-based and...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe search for cluster structure in microarray datasets is a base problem for the so-called "-omic sciences". A difficult problem in clustering is how to handle data with...Full Text Available

Science.gov (United States)

These steps are based on work done by the AIAA. Space-Based Observation Systems Committee on Standards (SBOS COS) as well as work done in this ..... Surface Weapons Center, Code B-10, Dahlgren, VA, 22448. Although it had many ...

UK PubMed Central (United Kingdom)

Most physicians dealing with Jehovah's Witnesses (JWs) who refuse blood-based treatment are uncertain as to any obligation to educate patients where it concerns the JW blood doctrine itself. They often...Full Text Available

International Nuclear Information System (INIS)

On the problem of alarm when parts are falling in nuclear power plant, the artificial neural network (ANN) alarm method based on the signal time-frequency characteristics was developed. The method was realized by the improved BP algorithm, and demonstrated with the data from simulation experiments

Energy Technology Data Exchange (ETDEWEB)

Using an expanded nuclear data base, the activation of nitrogen, aluminum, iron, nickel, copper, zirconium, niobium, molybdenum, tungsten, and lead were calculated for the first wall positions of the STARFIRE and MARS conceptual fusion reactors.

UK PubMed Central (United Kingdom)

Although previous intravascular ultrasound (IVUS) radiofrequency-based analysis data showed acceptable reproducibility for plaque composition, measurements are not easily obtained, particularly that...Full Text Available

UK PubMed Central (United Kingdom)

In many radiotherapy clinics, geometric uncertainties in the delivery of 3D conformal radiation therapy and intensity modulated radiation therapy of the prostate are reduced by aligning the...Full Text Available

Science.gov (United States)

...Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION QUALIFICATION AND CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the Certification Process § 240.109 General criteria for eligibility based on...

Science.gov (United States)

(General Stafford) was selected as chair for the Task Force based on his expertise .... a large foreign customer base that includes joint working agreements with Russia, the .... NASA Headquarters management advocates the Jorge Scientific ...

International Nuclear Information System (INIS)

... Toshiba Corporation, Isogo Engineering Center, Yokohama, Kanagawa (Japan)

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... The SMSP makes predictions based on historical precipitation data, precipitation ... are characterized by relatively large areas of strategic interest. ...

Science.gov (United States)

... Both magnesium and aluminium phosphides are therefore potentially more efficient than either calcium or sodium phosphide. ...

Wastenet

to set in place regulations and processes to manage river basins based upon the ecological (and hydro-morphological) health

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CERN Document Server

In this paper we have investigated the performance of PSO Particle Swarm Optimization based clustering on few real world data sets and one artificial data set. The performances are measured by two metric namely quantization error and inter-cluster distance. The K means clustering algorithm is first implemented for all data sets, the results of which form the basis of comparison of PSO based approaches. We have explored different variants of PSO such as gbest, lbest ring, lbest vonneumann and Hybrid PSO for comparison purposes. The results reveal that PSO based clustering algorithms perform better compared to K means in all data sets.

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... Lead researcher Dr Preethi Premkumar, who is based in the Division of Psychology at Nottingham Trent University, said: \\

Science.gov (United States)

... space vehicles, robot and machine guidance systems, and in various types of autonomous UUV docking situations. Page 3. ...

International Nuclear Information System (INIS)

Magnetic properties of a recently developed Fe-based amorphous alloy with a high saturation induction of 1.65 T are reviewed. The increased saturation induction is fully utilized in transformers with reduced magnetic losses, physical sizes and audible noises, minimizing some of the drawbacks of amorphous metal-based transformers based on a currently available amorphous alloy. Impacts of this on the worldwide energy savings and reduction of greenhouse gas emissions are discussed. A recent effort in achieving a saturation induction beyond 1.65 T in nanocrystalline alloys is mentioned.

Science.gov (United States)

... For the P-wave test, the seismic source was an exploding bridgewire (EBW) detonator which was sufficiently strong in energy ...

Science.gov (United States)

The progress in the development of a surface analysis tool based on the excitation of characteristic

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This paper describes web based simulation of Shuttle launch operations and debris dispersion. Java

Science.gov (United States)

... initiation) Pressed e Combustible Cartridge Cases Quantity-Distance Table ... Combustible Cartridge Cases, and Electrically Exploded Devices in ...

Science.gov (United States)

... FIELD CORROSION TESTS WERE MADE DURING THE VOYAGES OF THE SCIENTIFIC-RESEARCH SHIPS ACADEMICIAN VERNADSKII AND ...

International Nuclear Information System (INIS)

... Tsukuba, Ibaraki (Japan) 389 p. PARTICLE ACCELERATORS beam monitoring

Energy Technology Data Exchange (ETDEWEB)

A wrench is proposed for screwing and unscrewing lock connections, which includes a spring loaded base, a faceplate with low moment and high moment mechanisms and subassemblies for moving them. In order to increase the operational reliability, the wrench is equipped with uprights evenly disposed along the perimeter of the base with hinged suspensions for linking the base, the hinged suspension is made in the form of interconnected links for the upper and lower traverses with the hinges. One of the hinges is positioned between the upper traverse and the upright, while the other is located between the lower traverse and the base.

International Nuclear Information System (INIS)

... Labs., Albuquerque, NM (US) GENERAL AND MISCELLANEOUS data

Energy Technology Data Exchange (ETDEWEB)

The effective half-life based on urine bioassay results of Wolsung NPP's worker was calculated. The effective half-life for tritiated water vapour obtained was 5 {approx} 9 days. In comparison to 10 days reported for ICRP-30, it is lower than the corresponding half-life for Reference Man. Also, the half-life was calculated based on intake amount of daily water. According to this result, the metabolism was reviewed.

Energy Technology Data Exchange (ETDEWEB)

In this paper the possibility of configuring a water cooled Nuclear Thermal Propulsion (NTP) rocket, based on a Particle Bed Reactor (PBR) is investigated. This rocket will be used to operate on water obtained from near earth objects. The conclusions reached in this paper indicate that it is possible to configure a PBR based NTP rocket to operate on water and meet the mission requirements envisioned for it. No insurmountable technology issues have been identified.

Energy Technology Data Exchange (ETDEWEB)

We report the corrected intercomparison of the World Radiometer Reference (WRR) irradiance scale and the Electrotechnical Laboratory (ETL) spectral irradiance scale. In addition, we confirm the intercomparison precision using the test facility where the irradiance of ETL 500 W standard lamp can be measured directly with the cavity radiometer. The results showed that the irradiance based on the WRR scale was 0.5-0.7% lower than the one based on the ETL scale

International Nuclear Information System (INIS)

The structure and properties of composite powder coatings on the base of titanium carbide are studied. It is shown the electron-beam welding deposition of powders on the base of nickel and titanium carbide allows to produce of high-quality wear-resistant coatings which superior in density and hardness compared with sputtered ones. Changes of hardening phase volume percentage as well as composition of metal matrix make possible to control coatings hardness

Energy Technology Data Exchange (ETDEWEB)

This standard addresses the design bases for light water reactor, nuclear power plant structures and components essential for the protection of public health and safety from the potential adverse effects of pipe whip, jet impingement, pressurization of compartments outside containment, environmental conditions and flooding associated with a postulated pipe rupture. The design bases for missile protection and the design bases for containment pressurization are not within this standard.

Energy Technology Data Exchange (ETDEWEB)

This standard addresses the design bases for light water reactor, nuclear power plant structures and components essential for the protection of public health and safety from the potential adverse effects of pipe whip, jet impingement, pressurization of compartments outside containment, environmental conditions and flooding associated with a postulated pipe rupture. The design bases for missile protection and the design bases for containment pressurization are not within this standard.

International Nuclear Information System (INIS)

We investigate the construction of five-dimensional supergravity solutions that do not have any triholomorphic U(1) isometries. We construct a class of solutions that in various limits of parameters reduces to many of previously constructed five-dimensional supergravity solutions based on both hyper-Kaehler base spaces that can be put into a Gibbons-Hawking form and hyper-Kaehler base spaces that cannot be put into a Gibbons-Hawking form. We find a new solution which is over triaxial Bianchi type IX Einstein-hyper-Kaehler base space with no triholomorphic U(1) symmetry. One special case of this solution corresponds to a five-dimensional solution based on Eguchi-Hanson type II geometry.

British Library Electronic Table of Contents (United Kingdom)

This paper presents a probabilistic approach for structural robustness assessment for a timber structure built a few years ago. The robustness analysis is based on a structural reliability based framework for robustness and a simplified mechanical system modelling of a timber truss system. A complex timber structure with a large number of failure modes is modelled with only a few dominant failure modes. First, a component based robustness analysis is performed based on the reliability indices of the remaining elements after the removal of selected critical elements. The robustness is expressed and evaluated by a robustness index. Next, the robustness is assessed using system reliability indices where the probabilistic failure model is modelled by a series system of parallel systems.

International Nuclear Information System (INIS)

Here we reported a two-step procedure for preparing a novel polymeric based solid-solid phase change heat storage material. Firstly, a copolymer monomer containing a polyethylene glycol monomethyl ether (MPEG) phase change unit and a vinyl unit was synthesized via the modification of hydrogen group of MPEG. Secondly, by copolymerization of the copolymer monomer and phenyl ethylene, a novel polymeric based solid-solid phase change heat storage material was prepared. The composition, structure and properties of the novel polymeric based solid-solid phase change material were characterized by IR, "1H NMR, DSC, WAXD, and POM, respectively. The results show that the novel polymeric based solid-solid phase change material possesses of excellent crystal properties and high phase change enthalpy.

CERN Document Server

The interaction energies between the different types of bases of a single strand of DNA molecule have been calculated. Using these original values of energies the harmonic behavior of a number of base patterns of DNA has been studied. In view of the great interest aroused by the discovery of the role of the telomere segment of the DNA in the replication process and its possible link with the aging process, we have investigated, with simple models, the harmonic behavior of the telomeric pattern of bases as well as the thermodynamic response in the biological system. With these results a conclusion on the probable role of the telomeric pattern on aging has also been drawn. Here the calculated values of harmonic frequencies of the telomeric pattern of bases and of other possible patterns show that the telomeric pattern is associated with the highest vibrational frequency among all patterns of ...

Energy Technology Data Exchange (ETDEWEB)

Density is useful in deducing the spatial structure of coals. In this paper, nitrogen has been used instead of the commonly employed helium, for the gas displacement pycnometer based density determination of a number of coals of Indian origin. The results show that the nitrogen-based densities are always higher than the helium-based ones. Also, empirical relationships between the helium-based and nitrogen-based coal densities have been developed by two modeling methods, namely, multi-variable regression and artificial neural networks. Although the two models have fared well, the neural network model exhibits a relatively better prediction accuracy and generalization performance than the regression model. This study thus demonstrates that nitrogen, which is cheaper and easily available, can be used gainfully as the probe gas for estimating the true density of coals. 23 refs., 1 fig., ...

Energy Technology Data Exchange (ETDEWEB)

With the introduction of competition and diversification into retail utility services, rate-making methods are being rethought. Rates that are strictly cost-based may be too slow in responding to changes within the utility industry. And the advent of independent power production as a significant source of energy calls for greater flexibility in pricing of wholesale utility services as well. Various deregulation or reregulation plans have been formulated, including both price cap and price floor proposals. Some regulatory authorities have embraced market-based pricing over cost-based methods as the best solution to pricing problems. This article addresses Federal Energy Regulatory Commission response to market-based rates.

CERN Document Server

Mutually unbiased bases for quantum degrees of freedom are central to all theoretical investigations and practical exploitations of complementary properties. Much is known about mutually unbiased bases, but there are also a fair number of important questions that have not been answered in full as yet. In particular, one can find maximal sets of ${N+1}$ mutually unbiased bases in Hilbert spaces of prime-power dimension ${N=p^\\m}$, with $p$ prime and $\\m$ a positive integer, and there is a continuum of mutually unbiased bases for a continuous degree of freedom, such as motion along a line. But not a single example of a maximal set is known if the dimension is another composite number ($N=6,10,12,...$). In this review, we present a unified approach in which the basis states are labeled by numbers ${0,1,2,...,N-1}$ that are both elements of a Galois field and ordinary integers. This dual nature permits a ...

International Nuclear Information System (INIS)

In this paper, the authors describe the characteristics of design seismic input motions and recently observed seismic records of base isolated buildings in Japan. First, we describe some seismic design spectra for building structures which were adopted. Then we show response spectra and energy spectra of observed records obtained during two recent major earthquakes (The 1995 Hyogo-ken Nanbu Earthquake and the 2003 Tokachi-oki Earthquake), which demonstrate the effectiveness of base isolation against large amplitude earthquake ground motion. We also introduce the responses of base isolated buildings during some earthquakes including the Tokachi-oki Earthquake. These data were gathered through questionnaires sent to many engineers who had conducted response observations of base isolated buildings. Last, an example of a base isolated building on soft ground is shown. We point out the ...

International Nuclear Information System (INIS)

Decay sequences based on the 1/2"+[660] proton orbital have been identified in "1"7"1Ta and "1"7"7Re based on spin, parity, and large alignment. This decay sequence is observed higher in energy than predicted in cranking calculations based on modified oscillator potentials. Similarly known 1/2"-[541] decay sequences in these and other neighbouring isotopes are observed lower in energy than predicted. A reduction in the strength of the spin-orbit potential for protons is suggested as a solution to these problem. (orig.).