International Nuclear Information System (INIS)

Soybean is one of the most economical and nutritious food packed with basic nutrients that combat diseases stemming from mal- and under-nutrition. Despite its rich nutritional profile, use of soybean in food has been limited because soybean proteins are often associated with compounds, which could exert a negative impact on the nutritional quality of the protein. Trypsin inhibitor (TI) is one of the important anti-nutritional factors that exert negative effect by causing growth inhibition. Soybean cultivar VLS-2 was irradiated with 250 Gy gamma rays in a gamma cell (200) with 60Co source installed at BARC to induce mutations for low trypsin inhibitor content. Three mutants with lower levels of TI content were identified and can be utilized for developing elite varieties of soybean. (author)

International Nuclear Information System (INIS)

Ethidium bromide (EB) and ultraviolet light (UV) in combination are known to produce a synergistic induction of 'petite' mutants in yeast. Two other agents were combined with EB, 3-Carbethoxypsoralene (3 CPs) activated by 365 nm light or #gamma# rays. EB in combination with 3 CPs also resulted in an enhanced production of 'petite' mutants. After the photoaddition of 3 CPs in exponential phase cells, recovery of the 'petite' mutation during dark liquid holding was inhibited by the presence of EB producing an enhanced number of 'petite' mutants. The behavior of mitochondrial antibiotic resistance markers after individual and combined treatments with EB and 3 CPs indicates a random loss of markers after EB and a preferential loss of a certain region for the 3 CPs photoaddition. The combination of the two agents leads to an additivity of total drug marker losses rather than a synergistic loss. The combination of EB with ...

International Nuclear Information System (INIS)

(Oct 1982). India Lokeshwar Reddy, M. Bhalla, JK Osmania Univ., Hyderabad

International Nuclear Information System (INIS)

This report briefly describes the studies on the mechanism of in vivo DNA repairing by the author in Research Reactor Institute, Kyoto Univ. for the past 30 years. First, the ability of UV radiation to induce transformation was investigated with viral DNA. The formation of thymine-thymine dimer was found harmful to organisms and such dimers were removable by UV-radiation at a low frequency. The mutability was determined in three different E.coli strains with mutator gene, mutT, mutS or mutL. The ability to excise 8-oxoguanin developed in primer DNA was deficient in mutT and miss-pairing left after DNA replication could not be recovered in mutL and mutS strains. Further, DNA repairing mechanism was investigated in other microorganisms; single-strand cleavage caused by exposure to BNCB radiation (boron-neutron-captured beam) could not be repaired in E. coli. Whereas for Deinococcus radiodurans, of which survival rate was not decreased by ...

International Nuclear Information System (INIS)

Sesame varieties/genotypes showed a good response to radiation with gamma rays and treatments with EMS. In M_1 both gamma rays and EMS influenced germination, seedling height, survival of plants and pollen fertility/sterility, producing deleterious effects on these characters. Compared to black seeded genotypes, white seeded ones are more susceptible to radiation. Both gamma rays and EMS produced various types of morphological variations in M_2 generation. These were dwarf plant mutants, mottled and fleshy leaved mutants (sterile), fasciated stem, flower colour, altered phyllotaxy, early, uniculm, capsule size variations, multiple capsule/leaf axil, seed coat colour variations, indehiscent and semi-indehiscent type mutants. Moreover, studies on quantitative characters including seed yield revealed the induction of mutants in both positive and negative directions ...

International Nuclear Information System (INIS)

Energy conservation and local energy deposition are investigated in the context of coupled-particle (i.e., neutrons, gamma rays, and charged particles) transport analysis. For charged particles, the concept of group splitting the 1 = 0 transfer matrix to ensure both particle and energy conservation is introduced. Although these procedures are more complex than those found in the usual neutron or coupled-neutron gamma-ray problem, they yield a consistent approach for the calculation of local energy deposition.

Energy Technology Data Exchange (ETDEWEB)

The proposed short wavelength coherent light source driven by the SLAC 3 km linac might be used to induce transitions between nuclear isomeric states. If an isotope were found with energetically adjacent isomeric states, one short-lived and one long-lived, and it were possible to separate and concentrate the long-lived species, and other nuclear and solid-state parameters were favorable, it might be possible to convert sufficient population to the short-lived state to realize {gamma}-ray lasing. Even if the x-ray intensity were insufficient, study of such driven transitions would be quite valuable.

International Nuclear Information System (INIS)

Pregnant rats in 11d and 16d of their pregnancy were given one-off whole body exposure by "1"3"7Cs #gamma# rays to 0.2, 0.4, 0.9 and 2.0 Gy, respectively. Changes were observed in conditioned drinking response and cerebrum hippocampi cone cell number of the baby rats exposed to the #gamma# rays in different periods of their embryo development. As a result, that pregnant rats exposed to "1"3"7Cs #gamma# rays in different pregnant periods may induce significant decrease in cerebrum hippocampi cone cell number and achieving rate of conditioned drinking response of the babies. The dose-response relationship can be described by Y=a-b log_1_0D. The achieving rate of conditioned drinking response were significantly correlated to cerebrum hippocampi cone cell number in the babies, and the achieving rate of conditioned drinking response of the babies ...

UK PubMed Central (United Kingdom)

Activation-induced cytidine deaminase (AID) protein initiates Ig gene mutation by deaminating cytosines, converting them into uracils. Excision of AID-induced uracils by uracil-N-glycosylase...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Apoptosis is a pattern of cell death involving nuclear pycnosis, cytoplasmic condensation, and karyorrhexis. Apoptosis induced by continuous irradiation with gamma rays (externally given by a 137Cs source) or with beta rays (from tritiated water injected ip) was quantified in the crypts of two portions of mouse bowel, the small intestine and descending colon. The time-course change in the incidence of apoptosis after each type of radiation could be explained on the basis of the innate circadian rhythm of the cells susceptible to apoptotic death and of the excretion of tritiated water (HTO) from the body. For 6-h continuous gamma irradiation at various dose rates (0.6-480 mGy/h) and for 6 h after injection of HTO of various radioactivities (0.15-150 GBq per kg body wt), the relationships between dose and incidence of apoptosis were obtained. Survival curves were then constructed from the curves for dose vs incidence of ...

Energy Technology Data Exchange (ETDEWEB)

The alpha particle induced fission of {sup 209}Bi has been investigated for E{sub {alpha}} = 55.7 and 58.6 MeV using gamma ray spectrometry. The cross sections for the production of fission products have been determined. The mass distributions have been found to be broad with a peak near mass 104. The charge distribution has been studied at the same particle energies. The fractional cumulative yields of {sup 97}Zr, {sup 99}Mo, {sup 101}Mo, {sup 112}Pd and {sup 117m}Cd have been determined using gamma ray spectrometry. The width of charge distribution is broad. (orig.).

British Library Electronic Table of Contents (United Kingdom)

Mutation C1494T in mitochondrial 12S rRNA gene was recently reported in two large Chinese families with aminoglycoside-induced and nonsyndromic hearing loss (AINHL) and was claimed to be pathogenic. This mutation, however, was first reported in a sample from central China in our previous study that was aimed to reconstruct East Asian mtDNA phylogeny. All these three mtDNAs formed a subclade defined by mutation C1494T in mtDNA haplogroup A. It thus seems that mutation C1494T is a haplogroup A-associated mutation and this matrilineal background may contribute a high risk for the penetrance of mutation C1494T in Chinese with AINHL. To test this hypothesis, we first genotyped mutation C1494T in 553 unrelated individuals from three regional Chinese populations and performed an extensive search ...

International Nuclear Information System (INIS)

The effect of exposure to gamma rays on LPO contents in liver, spleen and kidney of mice and the anti-lipid-peroxidation of preparations of chinonin, tannic acid and squalene were reported. All these preparations were given by intragastric perfusion. For LPO, a modified method of TBA spectrophotometry was used for determination. The results show that LPO contents in tissues increased 72 h after whole-body exposure of mice to gamma rays, that in range of 0-4 Gy, there was a linear relationship between radiation doses and LPO contents, and that all three preparations were effective in reduction of the LPO content in liver, spleen and kidney of mice, with chinonin (at dose of 0.35 mg/mouse#centre dot#day) being more effective than tannic acid (at dose of 15 mg/mouse#centre dot#day) and squalene (at dose of 0.6 mg/mouse#centre dot#day).

International Nuclear Information System (INIS)

Since the commissioning of the first 10 strings of the AMANDA neutrino telescope, more than nine years of data has been collected. The proof of principle of high-energy neutrino detection in ice is established. No positive signal of an extra-terrestrial high-energy neutrino flux have been found so far. However, the most stringent upper limits to the flux of cosmic neutrinos-respectively, diffuse, point like or associated with gamma-ray bursts-have been presented. A sample of 3329 up-going muon tracks, representing the largest statistics ever of high-energy neutrino induced events, has been collected between 2000 and 2003. A coincidence of neutrino with an anomalous high-energy gamma-ray flare has been observed from the direction of the Blazar 1ES1959+650-although the observation were not conclusive. Selected results of data taken with the AMANDA detector are here reported.

Energy Technology Data Exchange (ETDEWEB)

In the investigations reported here, a helium-jet/tape-transport system was used for the rapid transfer of fission products to a low-background environment where their aggregate beta and gamma-ray spectra were measured as a function of delay time after neutron induced fission of {sup 235}U, {sup 238}U and {sup 239}Pu. Beta and gamma-ray energy distributions have been deduced for delay times as short as 0.2 s and extending out to 100,000s. Instrumentation development during the initial phase of the project included: (1) assembly and characterization of a NaI(Tl) spectrometer for determining aggregate gamma-ray energy distributions, (2) development and characterization of a beta spectrometer (having excellent gamma-ray rejection) for measuring aggregate beta-particle energy distributions, (3) assembly and characterization of a Compton-suppressed HPGe spectrometer for determining ...

CERN Document Server

Primordial black holes are unique probes of cosmology, general relativity, quantum gravity and non standard particle physics. They can be considered as the ultimate particle accelerator in their last (explosive) moments since they are supposed to reach, very briefly, the Planck temperature. Upper limits on the primordial black hole number density of mass $M_{\\star} = 5 10^{14}$ g, the Hawking mass (born in the big-bang terminating their life presently), is determined comparing their predicted cumulative $\\gamma$-ray emission, galaxy-wise, to the one observed by the EGRET satellite, once corrected for non thermal $\\gamma$-ray background emission induced by cosmic ray protons and electrons interacting with light and matter in the Milky Way. A model with free gas emissivities is used to map the Galaxy in the 100 MeV photon range, where the peak of the primordial black hole emission is expected. The best gas emissivities and ...

International Nuclear Information System (INIS)

The present study was designed to assess the radioprotective effects of amifostine on ovarian follicles. Three week-old female mice with or without pretreatment of amifostine were irradiated with 6.42 Gy of #gamma# -ray. Ovaries were collected 0 and 6h after irradiation. DNA fragmentation pattern and expression of genes and activity of proteins related with apoptosis were investigated by means of RT-PCR and Western blot. Proliferation of granulosa cells was reduced and incidence rate of follicular atresia was increased in ovarian follicles in #gamma# -ray irradiated mice compared to those in control or amifostine-treated group. DNA fragmentation was increased in time-dependent manner in granulosa cells of all irradiated groups. However, no difference between amifostine pre-treated group and irradiated groups was found and the expression of p53 as tumor suppressor gene and Bax as one of pro-apoptotic ...

Energy Technology Data Exchange (ETDEWEB)

Characterization of high temperature superconducting film and bulk samples has been carried out using 2 MeV [alpha]-particle Rutherford backscattering, 2.4 MeV proton elastic scattering, 2.4 MeV proton-induced x-ray emission, 9 MeV proton induced [gamma]-ray emission and 100 MeV iodine elastic recoil detection analysis techniques. The objective was to compare different ion beam based techniques for: (i) compositional analysis; and (ii) consistency of the results obtained for samples prepared using similar preparation methodology. (author).

International Nuclear Information System (INIS)

Epidermal growth factor receptor (EGFR) gene alterations have been found in human lung cancers. However, there is no information on the factors inducing EGFR mutations. In rodents, K-ras mutations are frequently found in many lung carcinogenesis models, but hitherto, Egfr mutations have not been reported. Their presence was therefore investigated in representative lung carcinogenesis models with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N-nitrosobis(2-hydroxypropyl)amine (BHP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) and ethyl carbamate (urethane), as well as X-ray irradiation. With the chemical carcinogenesis models, no mutations were detected in Egfr, which is in clear contrast to the high rates observed in either codon 12 or 61 of K-ras (21/23 of the lung tumors induced with NNK, 4/5 with MelQx, 1/4 with urethane and 7/18 with BHP). ...

Energy Technology Data Exchange (ETDEWEB)

Oxygen-16 induced fission studies of [sup 209]Bi have been carried out at particle energies of 89.5 MeV using gamma ray spectrometry. The cross sections for the production of fission products have been determined. The yield distribution of fission products has been found to be broad (FWHM [approx equal] mass units) with a peak near mass [approx equal] 108. The charge distribution in the [sup 16]O ion induced fission of [sup 209]Bi has also been studied at particle energy of 89.5 MeV. The relative cumulative yields of [sup 92]Sr, [sup 97]Zr, [sup 99]Mo, [sup 101]Mo, [sup 112]Pd and [sup 117m]Cd have been determined using gamma ray spectrometry. The width of charge distribution has been found to be broad. (orig.)

International Nuclear Information System (INIS)

The "1"6O induced fission studies of "2"0"9Bi have been carried out at particle energies of 89.5 MeV using gamma ray spectrometry. The cross sections for the production of fission products have been determined. The yield distribution of fission products has been found to be broad (FWHM=16) with a peak near mass 107. The charge distribution in the "1"6O particle induced fission of "2"0"9Bi has been studied at "1"6O particle of 89.5 MeV. The fractional cumulative yields of "9"2Y, "9"7Zr, "9"9Mo, "1"0"1Mo, "1"0"5Rh, "1"1"2Pd and "1"1"7"mCd have been determined using gamma ray spectrometry. (author). 7 refs., 2 tabs.

International Nuclear Information System (INIS)

The themal neutron sensitivities of SEI and Toshiba FD-P10-7 radiophotoluminescent silver activated metaphosphate glass dosimeters have been measured and studied theoretically. The graphite thermal neutron column attached to the AEEW reactor NESTOR was utilised as a source of thermal neutrons with minimal fast neutron and gamma-ray contamination. Both the neutron removal and gamma correction measurement techniques were applied and these gave consistent results. It was found that the thermal neutron sensitivity of the Toshiba dosimeters is comparable to the most neutron intensitive thermoluminescent materials available. Because of their larger size and higher silver concentration, however, SEI dosimeters are an order of magnitude more neutron sensitive. The neutron sensitivity of FD-7 glass has not been reported previously, whereas in the case of SEI glass, there exists a modest body of previous work on dosimeters of nominally identical composition. The present ...

Energy Technology Data Exchange (ETDEWEB)

A brief overview if provided of selected reports presented at the International Symposium on Molecular Mechanisms of Radiation- and Chemical Carcinogen-Induced Cell Transformation held at Mackinac Island, Michigan on September 19-23, 1993.

CERN Document Server

Determination of absorbed dose in a patient irradiated by beams of x or gamma rays in radiotherapy procedures

International Nuclear Information System (INIS)

We describe the analysis of forward mutations induced in the tetracycline resistance gene of the plasmid pBR322 by directing the reaction of the carcinogen N-acetoxy-N-2-acetylaminofluorene (N-AcO-AAF) to a small restriction fragment (BamHI, SalI) that is located in the proximal part of the antibiotic-resistance gene. Mutant plasmids obtained both in wild type and excision repair deficient (uvrA) bacterial cells are compared. Preliminary data showing the distribution of the -AAF adducts along this restriction fragments are discussed in relation to the observed spectrum of mutations. 20 references, 4 figures.

Science.gov (United States)

The research sponsored by this grant was conducted in two fields of high-energy astrophysics:

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Energy Technology Data Exchange (ETDEWEB)

This patent describes a {gamma}-ray detector. It comprises: a dislocation-free single crystal having an input surface and a transmission surface at opposite ends thereof; an active shield surrounding the crystal and functioning as an anticoincidence counter; and {gamma}-ray detector means disposed adjacent the transmission surface of the crystal for receiving and detecting {gamma}-rays of a predetermined wavelength incident on the input surface of the crystal at a specific Bragg angle and transmitted through the crystal.

International Nuclear Information System (INIS)

The cross section and activity profile of different radioisotopes produced by #alpha#-induced nuclear reaction on natural zirconium, have been obtained by stacked foil activation using 40 MeV #alpha#-particles from Variable Energy Cyclotron (VEC) machine at Calcutta. The activity profile would be used to study the surface loss of zircaloy materials of engineering components by thin layer activation (TLA) technique. Generally, isotopes with suitable #gamma#-rays and long half-lives are the most useful in TLA technique, e.g., "9"2Nb, "9"5"gNb and "9"5Zr. (author). 2 refs., 1 tab.

Energy Technology Data Exchange (ETDEWEB)

Proton induced X-ray emission (PIXE) and proton induced {gamma}-ray emission (PIGE) techniques are employed for the determination of essential and trace elements in some commonly used medicinal plants of north east India. Light elements such as Na, Mg, Al and P are determined by PIGE while medium Z elements such as K, Ca, Mn, Fe, Cu, Zn, Rb and Sr are determined by PIXE. Analysis is performed on pellets (thick targets) prepared using powders of the specimens which, in turn, are obtained following a series of processing steps. Plant based biological certified reference materials (CRMs) served as standards for quantification. These elements are found to be present in varying concentrations in the studied plants, with the contents of Mn and Zn being notably large in certain specimens. Medicinal properties possessed by these plants have been correlated with their elemental distribution.

Energy Technology Data Exchange (ETDEWEB)

Thermoluminescence (TL) properties of sphene and epidote are of interest in studies related to their radiation damage. Natural and artificially induced TL of these minerals has, therefore, been investigated. Both minerals exhibit complex glow curves with several overlapping peaks. The Tsub(m) -Tsub(STOP) thermal cleaning procedure has revealed three peaks in the ..gamma.. ray induced glow curve of each mineral. That these peaks obey second order kinetics was indicated by the continuously slanting structure of the Tsub(m)-Tsub(STOP) curve. The TL parameters E and s have been calculated using (i) the initial rise method, and (ii) the glow-peak shape method. In general, the values of E calculated by the first method are found to be higher than those from the second. The TL curve-fitting method is also applied in order to calculate these parameters and to serve as a cross-check on the results.

UK PubMed Central (United Kingdom)

Provisional mutational spectra at the hypoxanthine phosphoribosyl transferase (HPRT) locus in vitro have been worked out for acetaldehyde (AA) and benzo[a]pyrene diolepoxide (BPDE) in human (T)-lymphocytes...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo describe clinical data and to characterize mutations in the transforming growth factor beta-induced (TGFBI) gene in patients from three unrelated Chilean...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A method of detecting explosives in a vehicle includes providing a first rack on one side of the vehicle, the rack including a neutron generator and a plurality of gamma ray detectors; providing a second rack on another side of the vehicle, the second rack including a neutron generator and a plurality of gamma ray detectors; providing a control system, remote from the first and second racks, coupled to the neutron generators and gamma ray detectors; using the control system, causing the neutron generators to generate neutrons; and performing gamma ray spectroscopy on spectra read by the gamma ray detectors to look for a signature indicative of presence of an explosive. Various apparatus and other methods are also provided.

Energy Technology Data Exchange (ETDEWEB)

A method of detecting explosives in a vehicle includes providing a first rack on one side of the vehicle, the rack including a neutron generator and a plurality of gamma ray detectors; providing a second rack on another side of the vehicle, the second rack including a neutron generator and a plurality of gamma ray detectors; providing a control system, remote from the first and second racks, coupled to the neutron generators and gamma ray detectors; using the control system, causing the neutron generators to generate neutrons; and performing gamma ray spectroscopy on spectra read by the gamma ray detectors to look for a signature indicative of presence of an explosive. Various apparatus and other methods are also provided.

UK PubMed Central (United Kingdom)

The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines...Full Text Available

International Nuclear Information System (INIS)

Radiation induced polymerization of methylmethacrylate and copolymerization of styrene-acrylonitrile mixture in mamrase Carpinus betulus was carried out by means of #gamma#-ray, under different moisture levels and additives. Under all conditions the degree of polymerization was as high as 60%. No pronounced differences were observed in the kinetics of the polymerization of MMA either with moisture content of wood nor with kind and amount of additives. At high moisture (80% RH) content the dimensional stability of wood-PMMA was increased four fold as compared with untreated wood. The hardness increased about 100% for a weight conversion of monomer of about 30 to 40%. Hardness of this wood-polymer composite is comparable to that of the best noble woods in the world. (author).

Energy Technology Data Exchange (ETDEWEB)

Elemental analysis of some medicinal plants used in the Indian Ayurvedic system was performed by employing instrumental neutron activation analysis (INAA) and atomic absorption spectroscopy (AAS) techniques. The samples were irradiated with thermal neutrons in a nuclear reactor and the induced activity was counted by gamma ray spectrometry using an efficiency calibrated high resolution high purity germanium (HPGe) detector. Most of the medicinal plants were found to be rich in one or more of the elements under study. The variation in elemental concentration in same medicinal plants samples collected in summer, winter and rainy seasons was studied and the biological effects of these elements on human beings are discussed. (orig.)

Energy Technology Data Exchange (ETDEWEB)

Leafy samples often used as medicine in the Indian Ayurvedic system and vegetables were analyzed for 20 elements (As, Ba, Br, Ca, Ce, Cr, Cs, Co, Eu, Fe, K, La, Na, Rb, Sb, Sc, Sm, Sr, Th, Zn) by employing Instrumental Neutron Activation Analysis (INAA). The samples were irradiated at the 100 kW TRIGA-MAINZ nuclear reactor and the induced activities were counted by gamma ray spectrometry using an efficiency calibrated high resolution High Purity Germanium (HPGe) detector. The concentration of the elements in the medicinal and vegetable leaves and their biological effects on human beings are discussed.

Energy Technology Data Exchange (ETDEWEB)

The excitation function of ({alpha},{ital xn}) reactions on {sup 191}Ir (abundance 37.3%) and on {sup 193}Ir (abundance 62.7%) has been measured for the 17--55 MeV alpha-particle bombarding energy range. The stacked foil activation technique and {gamma}-ray spectroscopy were used to determine the cross sections. The experimental data were compared with calculated values obtained by means of a geometry-dependent hybrid model. The initial exciton number {ital n}{sub 0}=4 with {ital n}=2, {ital p}=2, and {ital h}=0 gives the best agreements with the presently measured results. To calculate the excitation function theoretically a computer code was used. This set of excitation functions provides a data basis for probing the validity of combined equilibrium and preequilibrium reaction models in a considerable energy range.

Energy Technology Data Exchange (ETDEWEB)

We summarize some initial results in our investigation of the nuclear physics issues of gamma-ray lasers. We describe what is known thus far from existing experimental data and illustrate how theoretical models may be employed for systematic searches of candidate nuclei.

Science.gov (United States)

The NS together with a gamma ray sensor make up the Gamma- Ray and ... A simplified view of the interactions between incoming cosmic rays and the .... held in Huntsville, Alabama, at the U.S. Space and Rocket Center on January 2830. ...

Energy Technology Data Exchange (ETDEWEB)

We present the results of modeling intended to evaluate the feasibility of using neutrons from induced fission in highly enriched uranium (HEU) as a means of detecting clandestine HEU, even when it is embedded in absorbing surroundings, such as commercial cargo. We characterized radiation from induced fission in HEU, which consisted of delayed neutrons at all energies and prompt neutrons at energies above a threshold. We found that for the candidate detector and for the conditions we considered, a distinctive HEU signature should be detectable, given sufficient detector size, and should be robust over a range of cargo content. In the modeled scenario, an intense neutron source was used to induce fissions in a spherical shell of HEU. To absorb, scatter, and moderate the neutrons, we place one layer of simulated cargo between the source and target and an identical layer between the target and detector. The resulting neutrons ...

International Nuclear Information System (INIS)

This paper reports regulation of hypoxia inducible factor-1 ? (HIF-1 ?)in hepatoma cells by irradiation. Cobalt chloride (CoCl2), a chemical mimic agent for hypoxia research, was utilized to induce the stable expression of HIF-1 ? in HepG2 cells. The HepG2 cells were irradiated to different doses to observe the changes of HIF-1 ?. The level of intracellular reactive oxygen species (ROS) was assayed by fluorescent microscope and flow cytometry (FCM). The results showed that there were obvious changes in expression of HIF-1 ? after HepG2 cells exposed to radiation, and the changes were positively related with the irradiation dose from 1 Gy to 5 Gy. Moreover, contents of incellular ROS were negatively correlated with above levels of HIF-1 ? from 1 Gy to 3 Gy. The results indicate that irradiation may enhance hypoxic cells HIF-1 ?, and the reduction of intracellular ROS can contribute to the regulation of ionizing radiation on HIF-1 ?. (authors)

Science.gov (United States)

The GRO observation (Hartman et al., 1992) of a very strong flux of gamma rays with an energy index

International Nuclear Information System (INIS)

Bulgarian (1973). Bulgaria Yankov, I. Sumrov, I. Stefanova, M. v.

CERN Document Server

Based on BACODINE network notification the Whipple Observatory gamma-ray telescope has been used to search for the delayed TeV counterpart to BATSE-detected gamma-ray bursts. In the fast slew mode, any point in the sky can be reached within two minutes of the burst notification. The search strategy, necessary because of the uncertainty in burst position and limited FOV of the camera, is described.

International Nuclear Information System (INIS)

The effect of irradiation using several doses of X- and #gamma#-rays (10, 20, 40, 60, 80 and 100 kGy), upon total phenolic compounds contained in the leaves of Maytenus aquifolium Martius (Celastraceae) 'espinheira santa', was investigated. The content of phenolic compounds (measured by the Folin-Denis spectrophotometric method) was unaffected by X- or #gamma#-ray irradiation, at any dose. (author)

Energy Technology Data Exchange (ETDEWEB)

The energy and intensity of gamma rays as seen in thermal neutron capture are presented. Only those (n,..cap alpha..), E = thermal, reactions for which the residual nucleus mass number is greater than or equal to 45 are included. These correspond to evaluations published in Nuclear Data Sheets. The publication source data are contained in the Evaluated Nuclear Structure Data File (ENSDF). The data presented here do not involve any additional evaluation. Appendix I lists all the residual nuclides for which the data are included here. Appendix II gives a cumulated index to A-chain evaluations including the year of publication. The capture gamma ray data are given in two tables - the Table 1 is the list of all gamma rays seen in (n,..gamma..) reaction given in the order of increasing energy; the Table II lists the gamma ...

Energy Technology Data Exchange (ETDEWEB)

Measurements of neutron and gamma-ray penetrations in an iron shield were performed up to a 60-cm depth in a tightly coupled source shield configuration with the fast-neutron reactor YAYOI as a source. Rates of neutron reactions and gamma-ray dose rates in the iron shield were obtained using activation foils and thermoluminescent dosimeters. Analyses of the experiments were made by using the DOT-III code with coupled neutron and gamma-ray cross sections from ENDF/B-IV and POPOP4 libraries. To obtain the source condition for the iron shield analyses, the calculated spectrum was adjusted to the measured reaction rates at the reactor shield boundary. The calculated neutron and gamma-ray distributions in the iron shield show fairly good agreement with the experiments. The effect of difference in Bondarenko-type self-shielding factors on the analyses of the iron shield is also shown.

International Nuclear Information System (INIS)

There are many differences between industrial CT and industrial radiography, such as imaging principle, inspection time, radiation dose and the requirements for operators etc. The national standards for radiation protection of industrial detection are not applicable to the requirements of protection and safety for #gamma#-ray industrial CT to some extent now. In order to standardize the production and use for #gamma#-ray industrial CT, protect the safety of operators and the public, and to promote the popularization and application of #gamma#-ray industrial CT, it is significant to establish the national standards for radiation protection of #gamma#-ray industrial CT as soon as possible. The purpose of this paper is to introduce the contents of this standard, and specify some important terms. Then there is a brief discussion on the existing problems during establishing such standards. At last, the paper ...

Energy Technology Data Exchange (ETDEWEB)

Using {gamma}-irradiation-induced reduction in the field of a {sup 60}Co {gamma}-ray source, colloidal silver and gold nanoparticles were prepared from their corresponding metal salts in aqueous solution and compared with those by chemical reduction. The radiation-based method provided silver nanoparticles with higher concentration and narrower size distribution than those obtained by chemical reduction method while there was no significant difference between the two strategies for the preparation of gold nanoparticles. {gamma}-Irradiation of 1.0 x 10{sup -3} M AgNO{sub 3} solution resulted in nearly 100 times more highly concentrated silver colloids than those by citrate reduction. Furthermore, the radiation method could lead to more highly concentrated silver colloids by simply increasing the concentration of AgNO{sub 3} solution up to 2.0 x 10{sup -2} M. The two metal nanoparticles prepared by the two different methods were characterized by ...

International Nuclear Information System (INIS)

Full text: A Large Sample Neutron Activation Analysis (LSNAA) facility is under development at GRR-1 research reactor, NCSR 'Demokritos'. The LSNAA facility design incorporates sample irradiation in the reactor's graphite thermal neutron column and subsequent measurement of the activity induced at a gamma spectroscopy system with gamma ray transmission measurement options included. Monte Carlo neutron and photon transport code MCNP-4C was used to model the facility. Appropriate correction factors accounting for neutron field perturbation during sample irradiation, high purity germanium detector efficiency for the volume source and gamma ray self-absorption within the sample itself were derived. The results of the computations were experimentally verified by activation foil measurements for a set of known materials and a range of sample sizes extending up to 10 litters. Moreover, the ...

International Nuclear Information System (INIS)

In experiments designed to detect new mutations affecting hemoglobin, we irradiated the male or female parent in reciprocal crosses of two mouse strains that differ in alleles at the hemoglobin (Hba, Hbb) loci as well as at five other specific loci. Offspring were analyzed for hemoglobin properties (electrophoretic pattern, solubility, crystal pattern), serum albumin differences, erythrocyte lysis, reticulocyte count, and external appearance. Five hemoglobin variants were found among the mutants. In three, the genetic contribution from the irradiated father was not expressed with regard to the #alpha#-chain; one carried a tandem duplication (the first known case in the mouse) involving Hbb; and one probably resulted from double nondisjunction of chromosome 7. The finding that major chromosome aberratios can mimic hemoglobin mutations indicates the need, in similar experiments, to follow F_1 screening with thorough cytogenetic analysis. The ...

International Nuclear Information System (INIS)

Ionizing radiation, mainly in the form of #gamma#-rays from the radioisotope cobalt 60, is being used increasingly for the inactivation of contaminants in cosmetic and toiletry preparations. The treatment is applied to the product in its final pack, and therefore, it is important to recognize that the properties of the packaging materials could be affected, particularly if high radiation doses are used. The stability of a wide range of materials is discussed. The nature and extent of chemical and physical changes in plastics very much depends on the presence of antioxidants and other additives, and on the environmental conditions during irradiation. Some useful information is available from research into the use of radiation for the preservation of food - many films and laminates have been cleared for use in the United States. The low radiation doses used for the control of contaminants in cosmetic products are quite unlikely to cause changes in packaging materials ...

International Nuclear Information System (INIS)

When the history of neutrons is considered, three large discoveries are recalled, that is, the discovery of neutrons by Chadwick in 1932, the discovery of the nuclear fission of uranium by Hahn and Strassmann in 1938, and the continuation of chain reaction in nuclear fission by Fermi and others in 1942. In neutron capture reaction, the reaction cross section can become very large. The fields of research, to which neutrons have contributed most as the experimental probe, are neutron activation analysis and neutron diffraction. The development of the prompt gamma ray analyzer at the JRR-3M in Japan Atomic Energy Research Institute is reported. This method eliminates the various defects in ordinary neutron activation analysis. By installing the cold neutron source with hydrogen cooling in the JRR-3M, the new field of research was opened. As the combination of a lead-moderated spectrometer and an electron beam type accelerator, the Kyoto University ...

International Nuclear Information System (INIS)

Excitation functions (EFs) for the reaction "1"4"1Pr(#alpha#, n)"1"4"4Pm and "1"4"1Pr(#alpha#, 2n)"1"4"3Pm have been measured using "1"4"1Pr as a target up to 50 MeV #alpha#-particle energy. Stacked foil activation technique and #gamma#-ray spectroscopy using 100 cm"3 Ge (Li) detector, has been used. Excitation functions are also calculated theoretically using Blann's geometry dependent hybrid (GDH) model code ALICE-91, with and without inclusion of pre-equilibrium particle emission. It has been observed that high-energy tails of the EFs are dominated by pre-equilibrium reaction mechanism. With the accepted set of input parameter, initial exciton number n_0=4 (2p + 2n + 0h), a good qualitative agreement is found. However, quantitative agreement for this magic nucleus"1"4"1Pr is also good when theoretical calculations are normalized by a multiple factor of 0.5. (author)

Energy Technology Data Exchange (ETDEWEB)

Cell death in general can be a physiological process of cell number regulation in tissue, or it can be the result of exo or endogenous injuries, such a low-dose of radiation. Chicken B cell population in the bursa of Fabricius are very susceptible to PCD. Our present studies concern the development of radiation damage of chicken defence mechanisms. In 6 experiments pathogen free chicken were irradiated by gamma rays with the total doses of 0.25, 0.5, 1.0, 2.0 and 4.0 Gy. The induction of apoptosis was checked by Flow-cyto-meter 12 h after irradiation in bursa cell suspension. There is some increase in the number of induced apoptotic cells 12 h after irradiation at the dose 0.5-.4.0 Gy. There were no significant changes in the proportion of proliferating lymphocytes (G2 M), but cellularity decreased significantly at dose 2.0 and 4.0 Gy/12 h after irradiation. (author)

Science.gov (United States)

Cross sections for (n,2n) (n,p) (n,{alpha}), and (n,d*){sup 1} reactions have been measured on ruthenium isotopes at the neutron energies of 13.5 to 14.8 MeV using the activation technique in combination with high-resolution gamma-ray spectroscopy. Data are reported for the following reactions: {sup 104}Ru(n,2n){sup 103}Ru, {sup 98}Ru(n,2n){sup 97}Ru, {sup 96}Ru(n,2n){sup 95}Ru, {sup 96}Ru(n,p){sup 96}Tc{sup g}, {sup 96}Ru(n,p){sup 96}Tc{sup m}, {sup 104}Ru(n,p){sup 104}Tc, {sup 102}Ru(n,p){sup 102}Tc{sup m}, {sup 104}Ru(n,{alpha}){sup 101}Mo, {sup 102}Ru(n,{alpha}){sup 99}Mo, {sup 96}Ru(n,{alpha}){sup 93}Mo{sup m}, and {sup 96}Ru(n,d*){sup 95}Tc{sup m}. Results were discussed and compared with the previous works.

CERN Document Server

2009 has been an extraordinary year for gamma-ray pulsar astronomy and 2010 promises to be equally good. Not only have we registered an extraordinary increase in the number of pulsars detected in gamma rays, but we have also witnessed the birth of new sub-families: first of all, the radio-quiet gamma pulsars and later an ever growing number of millisecond pulsars, a real surprise. We started with a sample of 7 gamma-ray emitting neutron stars (6 radio pulsars and Geminga) and now the Fermi-LAT harvest encompasses 24 "Geminga-like" new gamma-ray pulsars, a dozen millisecond pulsars and about thirty radio pulsars. Moreover, radio searches targeted to LAT unidentified sources yielded 18 new radio millisecond pulsars, several of which have been already detected also in gamma rays. Thus, currently the family of gamma-ray ...

Energy Technology Data Exchange (ETDEWEB)

Diffuse {gamma}-ray emission produced by the interaction of cosmic-ray particles with matter and radiation in the Galaxy can be used to probe the distribution of cosmic rays and their sources in different regions of the Galaxy. With its large field of view and long observation time, the Milagro Gamma Ray Observatory is an ideal instrument for surveying large regions of the Northern Hemisphere sky and for detecting diffuse {gamma}-ray emission at very high energies. Here, the spatial distribution and the flux of the diffuse {gamma}-ray emission in the TeV energy range with a median energy of 15 TeV for Galactic longitudes between 30{sup o} and 110{sup o} and between 136{sup o} and 216{sup o} and for Galactic latitudes between -10{sup o} and 10{sup o} are determined. The measured fluxes are consistent with predictions of the GALPROP model everywhere except for the Cygnus region (l ...

International Nuclear Information System (INIS)

Epidemiological studies will not solve the shape of the dose effect curve for stochastic effects in the low dose range. Unicellular processes are necessary for the primary processes so that no threshold dose exists. This is evident for somatic and genetic mutations. Not clearly solved is this question for the complex carcinogenesis. These processes develop with manifold interacting molecular and cellular steps. (orig.).

CERN Document Server

The periodic mode is analyzed together with two conventional boundary handling modes for particle swarm. By providing an infinite space that comprises periodic copies of original search space, it avoids possible disorganizing of particle swarm that is induced by the undesired mutations at the boundary. The results on benchmark functions show that particle swarm with periodic mode is capable of improving the search performance significantly, by compared with that of conventional modes and other algorithms.

International Nuclear Information System (INIS)

Tow experiments were carried out in 1981 and 1982 growth seasons at the greenhouse of the department of agriculture for soils and water researches, atomic energy authority, at inshas, to investigate the responses of two mutation derived lines of sesame and the local cultivar giza 25 to the application of micro nutrients. The possible effect of radiation on germination and growth of sesame seed was also studied in a separate experiment conducted in 1985 season, at inshas.

DEFF Research Database (Denmark)

Efflux of dopamine through the dopamine transporter (DAT) is critical for the psychostimulatory properties of amphetamines, but the underlying mechanism is unclear. Here we show that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) plays a key role in this efflux. CaMKIIalpha bound to the distal C terminus of DAT and colocalized with DAT in dopaminergic neurons. CaMKIIalpha stimulated dopamine efflux via DAT in response to amphetamine in heterologous cells and in dopaminergic neurons. CaMKIIalpha phosphorylated serines in the distal N terminus of DAT in vitro, and mutation of these serines eliminated the stimulatory effects of CaMKIIalpha. A mutation of the DAT C terminus impairing CaMKIIalpha binding also impaired amphetamine-induced dopamine efflux. An in vivo role for CaMKII was supported by chronoamperometry measurements showing reduced amphetamine-induced dopamine efflux in response to the ...

Science.gov (United States)

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The authors investigated the evolution and radiation characteristics of individual neutron stars and stellar systems. The work concentrated on phenomena where new techniques and observations are dramatically enlarging the understanding of stellar phenomena. Part of this project was a study of x-ray and gamma-ray emission from neutron stars and other compact objects. This effort included calculating the thermal x-ray emission from young neutron stars, deriving the radio and gamma-ray emission from active pulsars and modeling intense gamma-ray bursts in distant galaxies. They also measured periodic optical and infrared fluctuations from rotating neutron stars and search for high-energy TeV gamma rays from discrete celestial sources.

Energy Technology Data Exchange (ETDEWEB)

A number of concrete culverts used to retrievably store drummed, dry, radioactive waste at the Savannah River Site (SRS), were suspected of containing ambiguous quantities of transuranic (TRU) nuclides. These culverts were assayed in place for Pu-239 content using thermal and fast neutron counting techniques. High resolution gamma-ray spectroscopy on 17 culverts, having neutron emission rates several times higher than expected, showed characteristic gamma-ray signatures of neutron emitters other than Pu-239 (e.g., Pu-238, Pu/Be, or Am/Be neutron sources). This study confirmed the Pu-239 content of the culverts with anomalous neutron rates and established limits on the Pu-239 mass in each of the 17 suspect culverts by in-field, non-intrusive gamma-ray measurements.

International Nuclear Information System (INIS)

Gamma-ray spectrometric analysis was employed to determine the nuclides formed in thorium by neutron irradiation. Thorium sample was irradiated by neutron from a pure thermal neutron field, neutron field of Cd ratio of about 4, and epithermal neutron field, respectively. The former irradiation was carried out in a thermal neutron column provided for medical uses of neutrons, and the latters were done in the F-ring position of TRIGA II research reactor of Musashi Institute of Technology. The gamma-ray spectra were obtained and analyzed by employing a fully automatic gamma-ray analysis system named ''GAMA: giant frog:-SYSTEM'' developped by Musashi Institute of Technology. The formation of Pa-233 (U-233) was discussed quantitatively with respect to the difference of the neutron field. (author).

International Nuclear Information System (INIS)

The electron capture decay scheme of "2"0"3Bi is studied. Energies and relative intensities of gamma rays are given.

International Nuclear Information System (INIS)

The #gamma# rays following the #beta# decays of "8"8Kr and "8"8Rb have been studied, using both large volume Ge(Li) detectors for singles and coincidence measurements and anti-Compton spectrometry for singles measurements. Level schemes for "8"8Rb and "8"8Sr were constructed from the data and 74 of 81 #gamma# rays observed in the decay of "8"8Kr were placed in the "8"8Rb level scheme with 23 excited states. For the decay of "8"8Rb, all of the observed 27 #gamma# rays have been placed in the (well known) level structure of "8"8Sr. Spin and parity assignments have been deduced from #beta#-decay logft values and #gamma#-ray transition patterns. Possible shell model interpretations are presented for the level schemes.

International Nuclear Information System (INIS)

Apoptosis, or programmed cell death (PCD), is a fundamental process that protects organismal integrity. In earlier work, we demonstrated that over-expression of either of two anti-apoptotic members of the BCL-2 family (BCL-2 or BCL-X L could elevate the frequency of radiation-induced mutations at the autosomal TK1 locus in human TK6 lymphoblasts that express wild-type TP53. Ectopic expression of BCL-X L also elevated the frequencies of double-strand break-induced gene conversion. The purpose of this study is to determine if BCL-2 family proteins promote radiation mutagenesis indirectly through their suppression of PCD, or whether the 'pro-mutagenic' function of these proteins can be separated from their anti-apoptotic function. We developed stable transfectants of TK6 cells that express a mutated form of BCL-X L with a single amino acid substitution in the BH1 domain that is known to interfere with the ...

International Nuclear Information System (INIS)

Techniques of chemical analysis, amino acid sequencing and autoradiography are being used to study the frequency of incorporation of normally noncoded amino acids into hemoglobins and seminal fluid proteins. We are studying, by the sequencing of radiolabeled proteins followed by the recovery of ["3H] isoleucine phenylthiohydantoin by high-performance liquid chromatography, the frequency at which normally noncoded isoleucine is incorporated into hemoglobin because of base-substitution mutations versus translational errors. Irradiation increases the isoleucine content of human hemoglobin and the frequency of substitution of isoleucine for specific amino acids in rabbit hemoglobin. Studies to date indicate that these techniques have been developed sufficiently for initial analysis of the potential of drugs and environmental pollutants to induce base-substitution mutations in mammalian somatic cells.

Energy Technology Data Exchange (ETDEWEB)

Two general categories are discussed concerning the evolution of the solar system: the dualistic view, the planetesimal approach and the monistic view, the nebular hypothesis. The major points of each view are given and the models that are developed from these views are described. Possible applications of gamma ray astronomical observations to the question of the dynamic evolution of the solar system are discussed.

International Nuclear Information System (INIS)

New measurements of relative gamma-ray emission probabilities in the decay of "1"0"1Mo and "1"0"1Tc are reported. Previously published conversion-electron data have been used along with the gamma-ray data to formulate self-consistent decay schemes. (orig.).

International Nuclear Information System (INIS)

A time coincidence long baseline (250 km) cosmic ray detection system has been developed to search for bursts of high energy #gamma#-rays (E_0>= 10"1"3 eV) of extra-terrestrial origin. The system design incorporates the possibility of simultaneous observation over a variety of time scales between 1 #mu#s and 10 s. (Auth.).

International Nuclear Information System (INIS)

Neutron and gamma ray energy spectra were measured using an NE-213 scintillator at depths of 7.2, 15.2, and 22.2 cm in a tissue-equivalent phantom which was uniformly irradiated on one face by deuterium--tritium (DT) neutrons. Coupled neutron--gamma ray multigroup discrete-ordinates calculations were performed using semi-infinite slab geometry. These calculations were used to supplement the measured spectra below 1 MeV. Similar calculations were performed to study the perturbation in the phantom due to the detector. The measured and calculated spectra were used to determine the kerma distributions for neutrons and gamma rays at each location. The gamma radiation was determined to contribute more than 10% of the total dose at each depth. The calculated kerma also reveals that a knowledge of the gamma ray spectra below 1 ...

Energy Technology Data Exchange (ETDEWEB)

Because the number of neutrons and gamma rays and the energy spectrum of particles from spontaneous fission are well characterized for {sup 252}Cf, it can be used as a timed source of fission neutrons and gamma rays. The first such usage incorporated a {sup 252}Cf source into gas scintillators. This paper describes a timed source of neutrons and gamma rays made by depositing {sup 252}Cf on one electrode of a parallel plate ionization chamber that can then be used for determining detection-system characteristics. The emission time of neutrons from spontaneous fission has also been determined by recording the emission time of prompt gamma rays from a {sup 252}Cf source (not incorporated into a detector) adjacent to the surface of a solid or liquid scintillator. This well characterized source of neutrons can thus be used as ...

International Nuclear Information System (INIS)

Spontaneous mutation has been discovered and utilized in domestication of narrow-leafed lupin (Lupinus angustifolius L.). As the result of the domestication, lupin has become a dominant grain legume crop in Western Australia. Facing the new challenge of developing herbicide tolerance cultivars, chemical mutagenesis has been used to create new tolerance to herbicide. This paper reports the characterization of two lupin mutants (Tanjil-AZ-33 and Tanjil-AZ-55) that are highly tolerant to metribuzin herbicide. A dose response study over 8 doses revealed that Tanjil-AZ-33 was 6 times more tolerant to metribuzin than the original parental cultivar Tanjil by measure of LD50. This mutant Tanjil-AZ-33 is the most tolerant germplasm in narrow-leafed lupin. Both mutants also maintain the high resistance to the disease anthracnose as cv Tanjil. Seed yield based on small field plots (3.6 m"2) under irrigation was 4.2 t/ha for Tanjil-AZ-33 and 1.9 t/ha for Tanjil when the ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Neurodegenerative and neurometabolic disorders may cause significant morbidity and mortality in children. Imaging is important in early diagnosis of metabolic disorders and in determining the extent of brain injury. Especially after the development of new techniques such as diffusion-weighted magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), neuroimaging plays more important role in the diagnosis and management of these disorders. In these disorders, usually a mutation causes a clinically significant block in one or more metabolic pathways. This blockage usually results in either a deficiency of the product or in an accumulation of substrate with damage induced by either storage or toxicity. The presenting symptoms are usually nonspecific. In some of the ...

KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

Microcapsules consisting of alginate and hyaluronic acid that can be decomposed by radiation are currently under development. In this study, the composition of the microcapsule material was optimized by changing the amounts of alginate and hyaluronic acid. Solutions of 0.025%, 0.05%, 0.1%, 0.2%, or 0.4% (wt./vol.) hyaluronic acid were mixed into a 0.2% alginate solution. To these mixtures, carboplatin (0.2 mmol) was added and the resulting material was used for the capsule preparation. The capsules were prepared by spraying the material into a CaCl{sub 2} solution (0.34 mol/l) using a microatomizer. These capsules were irradiated by a single dose of 2, 5, or 10 Gy {sup 60}Co {gamma}-ray radiation. Immediately after irradiation, the releasing of core content of microcapsule was determined, using a micro particle induced X-ray emission (PIXE) camera. The average diameter of the microcapsules was 22.3 {+-} 3.3 {mu}m, and that of the liquid core ...

Energy Technology Data Exchange (ETDEWEB)

{gamma}-ray excitation functions have been measured for the interaction of fast neutrons with {sup 48}Ti (neutron energy from 1 MeV to 250 MeV). The Los Alamos National Laboratory spallation neutron source, at the LANSCE/WNR facility, provided a ''white'' neutron beam which is produced by bombarding a natural W target with a pulsed proton beam. The prompt-reaction {gamma} rays were measured with the large-scale Compton-suppressed Ge spectrometer, GEANIE. Neutron energies were determined by the time-of-flight technique. Excitation functions were converted to partial {gamma}-ray cross sections, taking into account the dead-time correction, the target thickness, the detector efficiency, and neutron flux (monitored with an in-line fission chamber). The data analysis is presented here for neutron energies between 1 to 20 MeV. Partial {gamma}-ray cross ...

International Nuclear Information System (INIS)

A theoretical model is developed to explain variations in airborne gamma-ray measurements over a calibration range near Ottawa, Ontario. The gamma-ray flux from potassium and the thorium decay series showed an expected decrease with increasing soil moisture. However, the gamma-ray flux from the uranium decay series was highest in the spring when the ground was water-saturated and even covered with snow. These results are explained through the build-up of radon and its associated gamma-ray-emitting decay products in the clay soil of the calibration range with increasing soil moisture. Similar results were found from airborne measurements over other clay soils. However, measurements over sandy soils showed that the count rates from all three radio elements increased with decreasing soil moisture. This difference between soil types was attributed to the lower radon emanation of the more coarse-grained ...

International Nuclear Information System (INIS)

Using high-resolution y-rays spectrometry, the natural radioactivity of 14 samples of natural and o manufactured Egyptian building materials have been investigated. The samples were collected from local market and construction sites. From the measured gamma-ray spectra, specific activities were determined. The radium equivalent activity in each sample was estimated. Radiological evaluations of these materials indicate that all materials meet the external gamma-ray dose limitation. Calculation of concentration indices by assuming a Markkanen room model is constructed from these materials, to find the excess gamma-ray dose taken over that received from the outdoors. The Austrian Standard ONORM S 5200 is used in testing the building materials.

International Nuclear Information System (INIS)

"1"0"1Mo is one of the key nuclides in diagnosing fission burn-up. However, it's difficult to measure its nuclear decay data due to its short half-life. Present study concerns in the measurements of #gamma#-ray emission probabilities, P_#gamma#, of "1"0"1Mo and "1"0"1Tc using the balance of scheme method and the entire process recording. The P_#gamma# of "1"0"1Mo by the entire process recording is about 5% lower than that by using the balance of scheme method. The P_#gamma# of "1"0"1Tc using the two methods agree each other very well. So, it seems the #gamma#-ray emission probabilities as well as measurement method still need study further for "1"0"1Mo. (authors)

Energy Technology Data Exchange (ETDEWEB)

Measurements of {gamma}-ray, {gamma}{gamma}-coincidence and internal conversion electron spectra from the {sup 106}Cd({alpha},n{gamma}){sup 109}Sn reaction were carried out at 15-20 MeV {alpha}-particle bombarding energies with Ge(HP) {gamma}-ray and superconducting magnetic lens plus Si(Li) electron spectrometers. The energies, relative intensities, internal conversion coefficients and coincidence relations of the {sup 109}Sn transitions were determined, and a more complete, consistent level scheme has been deduced. Spin and parity values have been determined from the internal conversion coefficients, the bombarding-energy dependence of the side-feeding intensities of the states and the available {gamma}-ray angular distribution data. The level scheme was interpreted in the framework of the quasi-particle shell model.

Energy Technology Data Exchange (ETDEWEB)

The effects of group structures and weighting functions on neutron penetration through a thick Na-Fe geometry are studied. The recommended broad-group (61-neutron/23-gamma-ray) and few-group (22-neutron/10-gamma-ray) structures are tailored to the sodium and iron resonances, windows, and capture gamma-ray spectra. The best weighting functions are shown to be fine-group fluxes selected from a few key locations in the geometry. These group structures and weighting functions, relative to existing group structures and conventional weighting functions, improve the accuracy of the computed 61-neutron-group Bonner ball responses by up to one hundred percent and of the computed 22-neutron-group results by up to six hundred percent.

International Nuclear Information System (INIS)

Pearls change their color to grey by #gamma#-ray irradiation. Grey densities were determined from darkness of pearl nuclei and thickness of the pearl layers. The densities are independent of both diameters of nuclei and pearls. The fading rate increases with increasing storage temperature. The rate of fading for irradiated pearls is lower than that for natural blue pearls. Comparison of photomicrographs (x 12) for pearls irradiated and then stored at room temperature for about 6 years revealed that their surfaces are not substantially different from the surfaces of unirradiated cultured pearls, indicating that #gamma# irradiation hardly gives rise to deterioration. #gamma#-Ray irradiation is a technique for coloration of pearls. Irradiated blue pearls seem to have resistivity to fading and to deterioration of the surface, if pearls have been irradiated properly. (author).

Energy Technology Data Exchange (ETDEWEB)

Data are presented to support the hypothesis that the initial step in the morphologic transformation of irradiated rodent (BALB/3T3) cells is a frequent cellular event involving a large fraction of the irradiated population. This process appears to involve DNA damage, but not to represent a targeted mutation in specific structural gene(s). Morphologic transformation and immortalization appear to be distinct steps in the overall process of transformation. In contradistinction to rodent cells, immortalization is a very rare event in human diploid cells which is induced at extremely low frequencies. The hypothesis is presented that immortality develops among clones of cells bearing stable chromosomal rearrangements which emerge during the proliferation of a population of radiation damaged cells.

CERN Document Server

In a recent paper by Hooper and Goodenough, data from the Fermi Gamma Ray Telescope was analyzed and an excess of gamma rays was found in the emission spectrum from the Galactic Center Region. Hooper and Goodenough show that the excess can be well explained by 7-10 GeV annihilating dark matter with a power law density profile if the dark matter annihilates predominantly to tau pairs. In this paper we present such a dark matter model by extending the MSSM to include four Higgs doublets and one scalar singlet. A Z2 symmetry is imposed that enforces a Yukawa structure so that the up quarks, down quarks, and leptons each receive mass from a distinct doublet. This leads to an enhanced coupling of scalars to leptons and allows the model to naturally achieve the required phenomenology in order to explain the gamma ray excess. Our model yields the correct dark matter ...

Energy Technology Data Exchange (ETDEWEB)

Detailed level and decay schemes and the experimental reaction and decay data on which they are based are presented for nuclei with mass number A = 242; the experimental data are evaluated. Adopted values for level and ..gamma..-ray energies, ..gamma..-intensities, as well as other nuclear properties are given.

Energy Technology Data Exchange (ETDEWEB)

Several configurations of moderating and shielding materials have been designed and measured on the LVR-15 reactor for boron neutron capture therapy (BNCT) purposes. To determine the neutron and gamma ray space-energy distributions in the cylindrical geometry, the two-dimensional code DOT with the coupled neutron-gamma data library DLC-36 was used. The experimental verification of the beam parameters was performed in the LVR-15 reactor thermal column empty space with layers of graphite, aluminium, alumina, lead and bismuth. Attention was paid to establishing techniques and instrumentation for monitoring the neutron and gamma ray dose and beam quality. The thermal and epithermal flux densities were measured by activation foils, the neutron spectrum was determined with a Bonner spectrometer and gamma ray background with a scintillation spectrometer. The ...

Energy Technology Data Exchange (ETDEWEB)

As reported previously (Namba et al., 1985), normal human fibroblasts were transformed by 60Co gamma-ray irradiation into immortal cells with abnormal karyotypes. These transformed cells (KMST-6), however, showed a low cloning efficiency in soft agar and no transplantability. However, upon treatment with Harvey murine sarcoma virus (Ha-MSV), the cells acquired elevated clonability in soft agar and transplantability in nude mice. Ha-MSV alone, however, did not convert normal human fibroblasts into either immortal or tumorigenic cells. The Ha-MSV-transformed KMST-6 cells showed an enhanced expression of the ras oncogene, but normal and 60Co gamma-ray-transformed cells did not. Our current data suggest that gamma rays worked against normal human cells as an initiator, giving rise to chromosome aberrations and immortality, and that Ha-MSV, probably through its ras oncogene, played a role in the progression ...

International Nuclear Information System (INIS)

A simulated hull monitoring system based on passive #gamma# ray scanning was set-up in K-01 hot-cell, which consists of a simulated hull basket, a collimator system, a 150 cm"3 HPGe detector and an ORTEC-919 multichannel buffer-computer system. Six different kinds of experimental set-up were established to simulate the variations of #gamma# ray source term distribution (partly concentration) and the variations of matrix density (+46.1%). The experimental results show that the biases of peak area is better than -25.3% for "1"3"7Cs 662 keV #gamma# rays and -18.6% for "1"4"4Ce-"1"4"4Pr 2186 keV #gamma# rays. The hardness of pulse height spectrum is demonstrated to show that the peak area ratio of 2186 keV to 662 keV varies from 380 to 72 when the thickness of lead filter varies form 5 mm to 30 mm. Also studied are the ...

CERN Document Server

In this work we develop a new propagation model for the Galactic cosmic rays based on the GALPROP code, including contributions from dark matter annihilation. The model predicts compatible Galactic diffuse $\\gamma$ ray spectra with EGRET data in all sky regions. It also gives consistent results of the diffuse $\\gamma$ ray longitude and latitude distributions. Further the results for B/C, $^{10}$Be/$^9$Be, proton, electron and antiproton spectra are also consistent with cosmic ray measurements. In the model we have taken a universal proton spectrum throughout the Galaxy without introducing large fluctuation for the proton energy loss is negligible. The dark matter annihilation signals are `boosted' after taking the contribution from subhalos into account. Another interesting feature of the model is that it gives better description of the diffuse $\\gamma$ rays ...

International Nuclear Information System (INIS)

A brief letter attempts to justify the assumption in an earlier paper of an isotropic distribution of environmental gamma rays incident on humans. A second letter from the original authors responds to this in yet more detail. (UK).

Science.gov (United States)

AGILE pointed observations performed from July 9, 2007 to October 30, 2009 are a recent, high quality gamma-ray data archive for monitoring studies of medium to high brightness gamma-ray sources in the 30 MeV -50 GeV energy range. We present a variability study of the 1AGL sources over the complete AGILE pointed Observation Blocks (OBs) dataset. The first AGILE Gamma-Ray Imaging Detector (GRID) catalog (Pittori et al. 2009) included a significance-limited (4 sigma) sample of 47 sources (1AGL), detected with a conservative analysis over a first-year non-uniform sky coverage dataset. In this analysis we used data of an improved full Field of View (FOV) event filter, on a much larger (about 27.5 months) observation dataset, analyzing each OB separatedly. This data processing resulted in an improved source list as compared to the 1AGL one. We present here some results on the variability of some of these sources.

Energy Technology Data Exchange (ETDEWEB)

Natural radioactivity found in rocks and its evaluation been frequently used for studies of environmental geochemistry, particularly those of detection and control of pollutants and the consequent changes in environment after antropic interferences. In this work natural radioactivity in forty nine soil samples in the basin of Buquira river, at the Northeast region of Sao Paulo State, has been analysed and measured with a Ge-HP gamma ray spectrometer. A table with the most relevant results found in rocks is shown and discussed. (author)

International Nuclear Information System (INIS)

Two experiments are currently underway to measure the single-particle weak mixing matrix element for the 1064 KeV transition in "2"0"7Pb. One experiment measures the circular polarization of the 1064 KeV gamma ray emitted from an unpolarized source, while the other experiment measures the forward-backward asymmetry of gamma rays emitted from a polarized source. Analysis of the first set of polarized source data yields an upper limit of 46 eV for the single-particle weak mixing matrix element. copyright 1995 American Institute of Physics.

CERN Document Server

A possible birefringence effect that arises in quantum gravity leads to a frequency-dependent rotation of the polarization angle of linearly polarized emission from distant sources. Here we use the UV/optical polarization data of the afterglows of GRB 020813 and GRB 021004 to constrain this effect. We find an upper limit on the Gambini & Pulin birefringence parameter $| \\eta | <2\\times 10^{-7}$. This limit is of 3 orders better than the previous limits from observations of AGNs and of the Crab pulsar. Much stronger limits may be obtained by the future observation of polarization of the prompt $\\gamma$-rays.

International Nuclear Information System (INIS)

A database has been designed for storing, retrieving and analyzing information about samples, experimental conditions and results obtained by neutron activation analysis and gamma-ray spectrometry. It has been created using Microsoft ACCESS 2002 under a Windows operating system. The database has been designed not only for saving information but also for quality assurance and quality control purposes. The structure of the relational design has been discussed and demonstrated with a new graphical feature of ACCESS 2002 called PIVOTCHART. (author)

Energy Technology Data Exchange (ETDEWEB)

The US DOE manages the safe storage of approximately 650,000 tons of depleted uranium hexafluoride remaining from the Cold War. This slightly radioactive, but chemically active, material is contained in more than 46,000 steel storage cylinders that are located at Oak Ridge, Tennessee; Paducah, Kentucky; and Portsmouth, Ohio. Some of the cylinders are more than 40 years old, and approximately 17,500 are considered problem cylinders because their physical integrity is questionable. These cylinders require an annual visual inspection. The remainder of the 46,000-plus cylinders must be visually inspected every four years. Currently, the cylinder inspection program is extremely labor intensive. Because these inspections are accomplished visually, they may not be effective in the early detection of leaking cylinders. The inspection program requires approximately 12--14 full-time-equivalent (FTE) employees. At the cost of approximately $125K per FTE, this translates to $1,500K per annum just ...

International Nuclear Information System (INIS)

The purified integral membrane protein, band 3, from human erythrocytes was inserted into egg lecithin liposomes. The insertion of band 3 was determined from thermal transition data from the analysis of the C-H stretching region bands recorded at temperatures from 25 to -22"oC. Raman spectra show that band 3 considerably broadens and lowers the thermal transition of egg lecithin liposomes, suggesting the insertion of band 3. The band 3-inserted liposomes were irradiated with gamma-rays (40 Gy) and the radiation target groups were determined by the analysis of the structural sensitive Raman bands in the 1600-1700 cm"-"1 (amide I), 1200-1300 cm"-"1 (amide III) and 550-1030 cm"-"1 (side chain amino groups) regions. The radiation-sensitive groups as identified from Raman spectra in the region 550-1030 cm"-"1 are tyrosines and cysteines. The radiation-induced changes in the secondary structure were determined from amide I and III bands. Quantitative ...

Energy Technology Data Exchange (ETDEWEB)

Proton induced X-ray and {gamma}-ray emission (PIXE/PIGE) have been used to analyze major and trace elements in a suite of 140 core samples from around of the Jim`s Find South gold anomaly in the Tanami desert, located in heavily weathered terrain. Simultaneous analyses were obtained for 30 elements, ranging in atomic number from {sup 3}Li to {sup 90}Th. The method was chosen because of its speed and the wide range of determination, its flexibility, precision and low detection limits. The regolith powder samples were treated by hot aqua regia before making them into pills. The PIXE/PIGE data of the acid insoluble residue give three factor analysis clusters. The first cluster comprises the elements F, Al, K, V, Mn, Fe, Ga, Rb, W and Au and is essentially related to sericitic wallrock alteration. The second cluster consists of Ti, As, Y, Zr, and Nb and is largely related to resistant minerals. The third cluster consists of Na, Ca and Sr and is ...

British Library Electronic Table of Contents (United Kingdom)

The E6 oncoproteins of high-risk human papillomaviruses provide important functions not only for malignant transformation but also in the productive viral life cycle. E6 proteins have been shown to bind to a number of cellular factors, but only a limited number of analyses have investigated the effects of these interactions on the viral life cycle. In this study, we investigated the consequences of HPV 31 E6 binding to E6TP1, a putative Rap1 GAP protein. HPV 16 E6 has been shown to bind as well as induce the rapid turnover of E6TP1, and similar effects were observed with HPV 31 E6. Mutation of amino acid 128 in HPV 31 E6 was found to abrogate the ability to bind and degrade E6TP1 but did not alter binding to another ?-helical domain protein, E6AP. When HPV 31 genomes containing mutations a...

DEFF Research Database (Denmark)

The recently observed X-ray synchrotron emission from four supernova remnants (SNRs) has strengthened the evidence that cosmic-ray electrons are accelerated in SNRs. We show that if this is indeed the case, the local electron spectrum will be strongly time-dependent, at least above roughly 30 GeV. The time dependence stems from the Poisson fluctuations in the number of SNRs within a certain volume and within a certain time interval. As far as cosmic-ray electrons are concerned, the Galaxy looks like actively bubbling Swiss cheese rather than a steady, homogeneously filled system. Our finding has important consequences for studies of the Galactic diffuse gamma-ray emission, for which a strong excess over model predictions above 1 GeV has recently been reported. While these models relied on an electron injection spectrum with index 2.4 (chosen to fit the local electron flux up to 1 TeV), we show that an electron injection index of around 2.0 would (1) be consistent ...

International Nuclear Information System (INIS)

A single amino acid substitution (Asp #-># Asn) at position 138 of E. coli EF-Tu was induced in the tufA gene by an M13 phage oligonucleotide site-directed mutagenesis protocol. The mutated tufA gene was then subcloned in a plasmid vector and expressed in maxicells. The properties of ["3"5S]methionine labelled mutant and wild type EF-Tu's were compared by in vitro assays. Mutant and wild-type EF-Tu's bound EF-Ts with approximately equal affinities. The 138-Asn mutation greatly reduced the protein's affinity for GDP; however, this mutation dramatically increased the proteins affinity for XDP. The mutant protein forms a stable complex with phe-tRNA and XTP, which binds to ribosomes; whereas, it does not form a complex with phe-tRNA and GTP. These results suggest that in EF-Tu x NDP complexes amino acid residue 138 must interact with the substituent on C-2 of the purine ring. Thus in wild-type EF-Tu ...

UK PubMed Central (United Kingdom)

Hereditary hypouricemia may result from mutations in the renal tubular uric acid transporter URAT1. Whether mutation of other uric acid transporters produces a similar phenotype is unknown. We studied...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

DFNA5 was first identified as a gene causing autosomal dominant hearing loss (HL). Different mutations have been found, all exerting a highly specific gain-of-function effect, in which skipping of exon 8 causes the HL. Later reports revealed the involvement of the gene in different types of cancer. Epigenetic silencing of DFNA5 in a large percentage of gastric, colorectal and breast tumors and p53-dependent transcriptional activity have been reported, concluding that DFNA5 acts as a tumor suppressor gene in different frequent types of cancer. Despite these data, the molecular function of DFNA5 has not been investigated properly. Previous transfection studies with mutant DFNA5 in yeast and in mammalian cells showed a toxic effect of the mutant protein, which was not seen after transfection ...

Science.gov (United States)

Summaries are included of research contracts which expired prior to Dec. 31, 1960. The contracts were concerned with investigations of: electrophysiological responses of biological systems in nerve cells to irradiation with small doses of ionizing radiations; the mode of the protective action of certain sulfhydryl compounds against radiation effects on the synthesis of deoxyribonucleic acid, using tritium-labeled thymidine; development of a bubble chamber method of monitoring and dosimetry for Low fast neutron fluxes; effects of incorporated radioisotopes on the stability of genetic materials; interrelation of root and leaf absorption of radioisotopes in herbaceous plants; uptake of radioactive wastes by lowland rice from soils contaminated by irrigation water, and decontamination of the rice; and comparison between mutation rates induced by acute and chronic gamma irradiations. (B.O.G.)

Energy Technology Data Exchange (ETDEWEB)

The presence of washed or unwashed cellophane alone or together with a bleomycin, mitomycin C or hydrochlorothiazide, ('Esidrex') showed no appreciable effect on survival of either unirradiated or irradiated conidia. Irradiation for a period of 20min reduced the survival of conidia to 20%. The growth of irradiated conidia in the presence of bleomycin, mitomycin C or Esidrex is associated with a 2- to 3-fold increase in the frequency of gene convertants, but was not accompanied by an increase in point mutants. When conidia were grown on cellophane but otherwise treated as before the frequency of gene convertants was increased 8-fold, but induction of point mutants was negligible. This effect was the same for irradiated and unirradiated conidia. The environment created by the cellophane in contract with the medium appears to affect the action of each of the three compounds synergistically.

UK PubMed Central (United Kingdom)

Recessive mutations of the early phase change (epc) gene in maize affect several aspects of plant development. These mutations were identified initially because of...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundMany difficult problems in evolutionary genomics are related to mutations that have weak effects on fitness, as the consequences of mutations with large effects are often...Full Text Available

International Nuclear Information System (INIS)

Personnel radiation monitoring is essential to the operation of any nuclear facility and work in this area continues to strive for an accurate determination of personnel dose. In particular recent attention has been focused upon the need to improve the accuracy of neutron dosimetry, mainly because of their high Relative Biological Effectiveness. In this work the feasibility of using the NE-213 liquid scintillation detector as an efficient neutron/#gamma# ray radiation monitor is demonstrated. Derivative method spectrum unfolding used in MATXUF for on-line analysis of fast neutron spectra has also been applied to real time #gamma# spectrum unfolding (MATXUF2), making possible simultaneous on-line monitoring of both fast neutrons and gammas. To eliminate the negative fluxes in the unfolded #gamma# spectra created by the photopeak-Compton edge combination in the plateau portion of the knee response, correcting equations using a linearized ...

CERN Document Server

The WIDeField telescope for Gamma-ray burst Early Timing (WIDGET) is used for a fully automated, ultra-wide-field survey aimed at detecting the prompt optical emission associated with Gamma-ray Bursts (GRBs). WIDGET surveys the HETE-2 and Swift/BAT pointing directions covering a total field of view of 62 degree x 62 degree every 10 secounds using an unfiltered system. This monitoring survey allows exploration of the optical emission before the gamma-ray trigger. The unfiltered magnitude is well converted to the SDSS r' system at a 0.1 mag level. Since 2004, WIDGET has made a total of ten simultaneous and one pre-trigger GRB observations. The efficiency of synchronized observation with HETE-2 is four times better than that of Swift. There has been no bright optical emission similar to that from GRB 080319B. The statistical analysis implies that GRB080319B is a rare event. This paper summarizes the design and operation of the ...

CERN Document Server

The nature of the hard X-ray source XSSJ12270-4859 is still unclear though it was claimed to be a magnetic Cataclysmic Variable. We here present a broad-band X-ray and gamma ray study based on a recent XMM-Newton observation and archival INTEGRAL and RXTE data. From the Fermi/LAT 1-year point source catalogue, we tentatively associate XSSJ12270-4859 with 1FGLJ1227.9-4852, a source of high energy gamma rays with emission up to 10GeV. We complement the study with UV photometry from XMM-Newton and ground-based optical and near-IR photometry. The X-ray emission is highly variable showing flares and intensity dips. The X-ray flares consist of flare-dip pairs. Flares are also detected in the UV range but not the dips. Aperiodic dipping behaviour is also observed during X-ray quiescence but not in the UV. The 0.2-100keV spectrum is featureless and described by a power law model with Gamma=1.7. The 100MeV-10GeV ...

CERN Document Server

Gravitational parity violation is a possibility motivated by particle physics, string theory and loop quantum gravity. One effect of it is amplitude birefringence of gravitational waves, whereby left and right circularly-polarized waves propagate at the same speed but with different amplitude evolution. Here we propose a test of this effect through coincident observations of gravitational waves and short gamma-ray bursts from binary mergers involving neutron stars. Such gravitational waves are highly left or right circularly-polarized due to the geometry of the merger. Using localization information from the gamma-ray burst, ground-based gravitational wave detectors can measure the distance to the source with reasonable accuracy. An electromagnetic determination of the redshift from an afterglow or host galaxy yields an independent measure of this distance. Gravitational parity violation would manifest itself as a discrepancy between these two ...

Science.gov (United States)

The gadolinium isotopes are interesting for reactor applications as well as for medicine and astrophysics. The gadolinium isotopes have some of the largest neutron capture cross sections. As a consequence they are used in the control rod in reactor fuel assembly. From the basic science point of view, there are seven stable isotopes of gadolinium with varying degrees of deformation. Therefore they provide a good testing ground for the study of deformation dependent structure such as the scissors mode. Decay gamma rays following neutron capture on Gd isotopes are detected by the DANCE array, which is located at flight path 14 at the Lujan Neutron Scattering Center at Los Alamos National Laboratory. The high segmentation and close packing of the detector array enable gamma-ray multiplicity measurements. The calorimetric properties of the DANCE array coupled with the neutron time-of-flight technique enables one to gate on a ...

International Nuclear Information System (INIS)

In future collider experiments, where a background radiation level is estimated to be very high, e.g. around 10"2 #approx# 10"5 Gy/yr and 10"1"1 #approx# 10"1"4 n/cm"2/yr at SSC, the detectors operating around the collision point in the experiments will encounter a considerable amount of radiation. Therefore, the detectors, especially the calorimeter, are required to be resistive against high radiation levels. From this point of view, it is of great importance to study the effects of radiation damage on the performance of the detectors. The authors report preliminary results of measurements of radiation hardness of the plastic scintillating fiber Kuraray SCSF-81 against irradiation with fast neutrons and "6"0Co #gamma#-rays in the region of the neutron fluence from 1 x 10"1"1 to 5 x 10"1"3 n/cm"2 and the integrated #gamma#-ray dose from 890 to 10"5 Gy, respectively. Deterioration of both intrinsic light yield and light transmittance of the ...

CERN Document Server

The principal paradigm for gamma-ray bursts (GRBs) suggests that the prompt transient gamma-ray signal arises from multiple shocks internal to the relativistic expansion. This paper explores how GRB prompt emission spectra can constrain electron (or ion) acceleration properties at the relativistic shocks that pertain to GRB models. The array of possible high-energy power-law indices in accelerated populations is highlighted, focusing on how spectra above 1 MeV can probe the field obliquity in GRB internal shocks, and the character of hydromagnetic turbulence in their environs. When encompassing the MeV-band spectral break, fits to BATSE/EGRET burst data indicate that the preponderance of electrons responsible for the prompt emission reside in an intrinsically non-thermal population. This differs markedly from typical populations generated in acceleration simulations; potential resolutions of this conflict such as the action of self-absorption ...

CERN Document Server

We investigate monoenergetic gamma-ray signatures of Z^1 dark matter annihilations in a non-minimal Universal Extra Dimensions model. The self-interactions of the non-Abelian Z^1 gauge boson give rise to a large number of contributing Feynman diagrams that do not exist for annihilations of the Abelian gauge boson B^1, which is the standard Kaluza-Klein dark matter candidate. We find that the annihilation rate is indeed considerably larger for the Z^1 than for the B^1. Even though relic density calculations indicate that the mass of the Z^1 should be larger than the mass of the B^1, the predicted fluxes are of the same order of magnitude. We compare our results to existing experimental limits, as well as to future sensitivities, for image air Cherenkov telescopes, and we find that the limits are reached already with a moderately large boost factor. However, the realistic prospects for detection depend on the energy resolution, as well as on the continuous ...

International Nuclear Information System (INIS)

A programme has been initiated by the Coordinating Office for Monitoring of enhanced natural radioactivity of the Federal Office for Radiation Protection to investigate different kinds of sample materials with enhanced naturally occurring radioactivity (NORM) such as scales from oilfield and naturally gasfield pipes, blast furnace sludge and sinter dust from the production of pig iron, as well as bauxit and red mud from the production of aluminium oxide. The aim of these investigations is to find proper preparation and measuring methods which allow, in particular, a sample treatment with optimised effort combined with a reliable determination of the specific activities of the dominating radionuclides. Of particular interest is the method of gamma-ray spectrometry, since this method has been used for most of our studies of sample materials. Due to different compositions of calibration and NORM-samples, e.g. different densities, and the analysis of low-energy ...

Energy Technology Data Exchange (ETDEWEB)

Yet designed to measure charged component of the cosmic rays, the foreseen Alpha Magnetic Spectrometer (AMS-02) could also release {gamma}-ray studies, in the energy range from GeV to TeV, using the tracker system, for {gamma}-rays converted in e{sup +}e{sup -} pair, and the electromagnetic calorimeter. In the first part of the thesis are described the calibrations and the performances of the engineering model of the calorimeter, obtained from the analysis of data taken during a test-beam performed at CERN in July 2002. In the second part of the thesis, the AMS-02 discovery potential for {gamma}-astrophysics is presented. While exposure maps of the {gamma}--sky are computed for one year of data taking with the {gamma}--detectors, the acceptance of the calorimeter is obtained from Monte-Carlo simulations. The AMS-02 potential is then estimated for signals from the Vela pulsar and for some supersymmetric signals from the Galactic Center. (author)

CERN Document Server

Gamma-Ray Bursts (GRBs) are thought to originate at cosmological distances from the most powerful explosions in the Universe. If GRBs are not beamed then the distribution of their number as a function of gamma-ray flux implies that they occur once per (0.3-40) million years per bright galaxy and that they deposit >10^{53} ergs into their surrounding interstellar medium. The blast wave generated by a GRB explosion would be washed out by interstellar turbulence only after tens of millions of years when it finally slows down to a velocity of 10 km/s. This rather long lifetime implies that there could be up to several tens of active GRB remnants in each galaxy at any given time. For many years, radio observations have revealed the enigmatic presence of expanding neutral-hydrogen (HI) supershells of kpc radius in the Milky Way and in other nearby galaxies. The properties of some supershells cannot be easily explained in terms of conventional ...

CERN Document Server

We construct models for gamma-ray bursts where the emission comes from internal shocks in a relativistic wind with a highly non uniform distribution of the Lorentz factor. We follow the evolution of the wind using a very simplified approach where a large number of layers interact by direct collisions but where all pressure waves have been suppressed. We suppose that the magnetic field and the electron Lorentz factor reach large equipartition values in the shocks. Synchrotron photons emitted by the relativistic electrons have a typical energy in the gamma-ray range in the observer frame. Synthetic bursts are constructed as the sum of the contributions from all the internal elementary shocks and their temporal and spectral properties are compared to the observations. We reproduce the diversity of burst profiles, the ``FRED'' shape of individual pulses and the short time scale variability. Synthetic bursts also satisfy the duration-hardness ...

International Nuclear Information System (INIS)

We present changes in the p53 gene in a group of 70 thyroid tumours and 40 blood samples obtained from children from Belarus. Three thyroid tumours show a polymorphism in exon 6 (codon 213) and 5 tumours show a polymorphism in intron 6, 37 bp upstream to the 5'-end of exon 7. Only one patient has a mutation in exon 7 (codon 258) resulting in an amino acid substitution in the protein p53. The distribution of polymorphisms in the 40 blood samples was as follows: three patients had a polymorphism in exon 6 and two persons had a polymorphism in intron 6. One polymorphism in intron 6 was also found in the group of 30 healthy children from Belarus. The fact that the differences in the sequence in p53 found in the tumours was also seen in the blood of these patients demonstrates that they are polymorphisms not induced by radiation exposure. It is difficult to conclude, if the polymorphisms found by us could be associated with the predisposition to ...

Energy Technology Data Exchange (ETDEWEB)

Natural sunlight induces a genotoxic response in cultured CHO cells pre-treated with shale oil retort process water. Near ultraviolet light (NUV) component of the solar spectrum is the apparent radiation responsible for photoactivation. Cultured human skin fibroblasts are acutely sensitive to the genotoxic effects of photoactivated process water. The mutagenic potential of photoactivated process water in human cells is the same as that witnessed for an equivalent killing dose of the potent skin carcinogen FUV. DNA repair processes are involved in modulating genotoxic effects of this photo-induced process. The exact magnitude of the potential health-related and environmental risks resulting from photoactivation of retort process waters and other oil shale by-products is unassessed at this time. Our demonstration that a significant rate of mutation occurs in cultured human cells exposed to high dilutions of process waters and ...

DEFF Research Database (Denmark)

Udgivelsesdato: 2006/8

Energy Technology Data Exchange (ETDEWEB)

In this paper we present status and developments of the Duke storage ring facility. The Duke storage ring facility provides the unique combination of phase-locked light sources ranging from high power OK-4 XUV FEL to quasimonochromatic {gamma}-ray beam and IR/X-ray spontaneous radiation. The XUV OK-4 FEL, which is collaborative project with BlNP, Novosibirsk, is in operation since November, 1996. The OK-4 UV FEL is also used for production of nearly monochromatic {gamma}-ray s with tunable energy. We present the results of UV lasing with the OK4 FEL and selected results of its applications. We will discuss our future plans for extension of this source and status of the construction of dedicated used facility adjacent to the FEL building. (author)

International Nuclear Information System (INIS)

The decay of "1"0"1Mo to levels in "1"0"1Tc has been studied using the three-parameter (#gamma#-#gamma#-t) coincidence system of HpGe-HpGe detectors. From the coincidence data, the new decay scheme was constructed. The previously reported 104.70, 105.95 and 774.15 keV #gamma# rays were observed, and have been assigned to the decay scheme for the first time. A newly observed 1508.01 keV #gamma# ray has also been assigned to the scheme for the first time. The intensities of #beta#"- and the values of log ft to most levels were calculated

CERN Document Server

Relativistic strongly magnetized winds outflowing from fast-rotating compact objects like millisecond pulsars with surface magnetic fields of $\\sim 10^{15}-10^{16}$ G are plausible sources of cosmological $\\gamma$-ray bursts. In such winds, there are at least three regions where extremely powerful X-ray and $\\gamma$-ray emission may be generated. The first radiating region is the wind photosphere that is at a distance of $\\sim 10^9$ cm from the compact object. The second radiating region is at a distance of $\\sim 10^{13}-10^{14}$ cm. In this region, the striped component of the wind field is transformed into large-amplitude electromagnetic waves. The third radiating region is at a distance of $\\sim 10^{16}-10^{17}$ cm, where deceleration of the wind due to its interaction with an ambient medium becomes important. Radiation from all these regions is considered.

Energy Technology Data Exchange (ETDEWEB)

We studied the effects of small, <20 {micro}m, Te inclusions on the energy resolution of CdZnTe gamma-ray detectors using a highly collimated X-ray beam and gamma-rays, and modeled them via a simplified geometrical approach. Previous reports demonstrated that Te inclusions of about a few microns in diameter degraded the charge-transport properties and uniformity of CdZnTe detectors. The goal of this work was to understand the extent to which randomly distributed Te-rich inclusions affect the energy resolution of CZT detectors, and to define new steps to overcome their deleterious effects. We used a phenomenological model, which depends on several adjustable parameters, to reproduce the experimentally measured effects of inclusions on energy resolution. We also were able to hound the materials-related problem and predict the enhancement in performance expected by reducing the size and number of Te inclusions within the crystals.

CERN Document Server

Dark Matter annihilation (DMA) may yield an excess of gamma rays and antimatter particles, like antiprotons and positrons, above the background from cosmic ray interactions. The excess of diffuse Galactic Gamma Rays from EGRET shows all the features expected from DMA. The new precise measurements of the antiproton and positron fractions from PAMELA are compared with the EGRET excess. It is shown that the charged particles are strongly dependent on the propagation model used. The usual propagation models with isotropic propagation models are incompatible with the recently observed convection in our Galaxy. Convection leads to an order of magnitude uncertainty in the yield of charged particles from DMA, since even a rather small convection will let drift the charged particles in the halo to outer space. It is shown that such anisotropic propagation models including convection prefer a contribution from ...

CERN Document Server

This paper presents a review of the history, motivation and current status of high energy neutrino telescopes. Many years after these detectors were first conceived, the operation of kilometer-cubed scale detectors is finally on the horizon at both the South Pole and in the Mediterranean Sea. These new detectors will perhaps provide us the first view of high energy astrophysical objects with a new messenger particle and provide us with our first real glimpse of the distant universe at energies above those accessible by gamma-ray instruments. Some of the topics that can be addressed by these new instruments include the origin of cosmic rays, the nature of dark matter, and the mechanisms at work in high energy astrophysical objects such as gamma-ray bursts, active galactic nuclei, pulsar wind nebula and supernova remnants.

International Nuclear Information System (INIS)

Excited states in the T_z=(1/2) nucleus "8"5Mo have been observed for the first time with the reaction "5"8Ni("3"2S,#alpha#n#gamma#) at 105 MeV. #gamma#-ray transitions in this nucleus have been assigned unambiguously by combining the information from the GASP #gamma#-ray array, the ISIS silicon ball, and the n-Ring neutron detector. Two band structures have been observed in this nucleus; they continue the smooth evolution of the known bands from the lighter N=43 isotones and have been tentatively assigned spins and parity on this basis. After reaching a maximum of collectivity at "8"3Zr, the trend with increasing mass is reversed, showing a smaller collectivity at "8"5Mo. The rotational behavior of the observed bands is discussed on the basis of the projected shell model calculations.

Energy Technology Data Exchange (ETDEWEB)

Neutron capture ..gamma..-ray spectra have been measured at 11 average neutron energies from 10 to 530 keV in /sup 88/Sr using a 20 x 15 cm NaI detector with time-of-flight discrimination of background events. The partial radiation widths and the calculated partial valence widths are compared for the strong p-wave resonances at 287 and 321 keV and found to be highly correlated. At these energies, the spectra are dominated by strong transitions to low-lying single particle states, in confirmation of the role of valence capture in the 3p region. However, the data do not support this mechanism at <508> keV.

International Nuclear Information System (INIS)

Lupinus albus L. plants were grown from seeds and irradiated at various stages of development with acute or chronic gamma rays. All plants were greenhouse grown (pre- and post-irradiation) and allowed to proceed through their normal growth cycle. The purpose of these experiments was to establish a Plactochron Index for Lupinus albus L. and to determine the effects of acute and chronic irradiation on development at the macro and microscopic levels. A Plastochron Index was calculated and used as an indirect time scale to evaluate the effects of gamma rays from a common base line. Acute radiation treatment lasted for a period of a few days, whereas chronic treatment was initiated at the seedling stage and lasted for the entire growth season. Vegetative plants were used to study the effects of acute radiation exposure on apical meristem morphology, Plastochron Index, phyllatoxis and gross morphology.

Science.gov (United States)

Dislocation priming measurements were performed in the kHz range in ASARCO copper. The samples and irradiation facilities are constructed so as to allow successive irradiation of samples both with electrons and gamma rays. The gamma rays were produced by stopping 2.8-MeV electrons in a gold target. The change of the type of irradiation could be achieved without any handling of the sample. Thus it is possible to detect rather small differences between the two types of irradiation. Recovery experiments at 400 deg K after 75 deg K irradiation and pinning rates during irradiation at 400 deg K and 75 deg K were made. (GE)

International Nuclear Information System (INIS)

Changing cream pearls into bluish-grey by #gamma# ray irradiation is a technique in coloring of pearls. Irradiated pearls are similar in color to cultured blue pearls. The pearl layers hardly change their color but the nuclei change into dark brown by irradiation. Visible light (500 - 700 nm) penetrating the pearl layer is absorbed by dark brown nucleus. The intensity of reflecting light between 400 and 500 nm at pearl surface, therefore, becomes stronger than that between 500 and 700 nm; therefore color of irradiated pearls look bluish-grey. The density of bluish-grey color increases with increasing absorbed doses, but their luster at surface diminishes owing to the deterioration of the pearl layer by prolonged irradiation; high doses irradiation should be avoided. Irradiated pearls show no substantial fading of their color in a year and the rate of the fading is found to be lower than that for cultured blue pearls. (author).

International Nuclear Information System (INIS)

The behavior of the triterpenes friedelin and friedelan-3-ol, contained on the leaves of Maytenus aquifolium Martius (Celastraceae), upon several doses of X- and #gamma#-rays (10 to 100 kGy), was investigated by high resolution gas chromatography (HRGC) and high resolution gas chromatography -mass spectrometry (HRGC-MS). The friedelin content has not changed with #gamma#-irradiation, but the content of friedelan-3-ol decreased around 17% at doses of 10, 20 and 40 kGy and around 27% at doses of 60, 80 and 100 kGy. The levels of both triterpenes remained unchanged even at higher X-ray doses. Lupen-3-one was detected by HRGC-MS. (author).

International Nuclear Information System (INIS)

A large area Bragg curve spectroscopy (BCS) detector and a position sensitive parallel grid avalanche counter have been developed to study heavy ion reactions, such as inelastic excitations and few nucleon transfer reactions near the Coulomb barrier. Reasonably good resolutions have been achieved for energy, atomic number and angle. A theoretical investigation on the mass dependence of the Bragg peak signal from the BCS detector, shows that there is a negligible mass dependence related to the geometry of the detector. The mass number of the heavy ions which cannot be obtained by the above method, has been identified by detecting the corresponding characteristic gamma rays from the product nuclei with two large solid angle gamma ray detectors. (orig.).

Energy Technology Data Exchange (ETDEWEB)

The paper describes the different methods, used in the MAGIC experiment, to unfold experimental energy distributions of cosmic ray particles ({gamma}-rays). Questions and problems related to the unfolding are discussed. Various procedures are proposed which can help to make the unfolding robust and reliable. The different methods and procedures are implemented in the MAGIC software and are used in most of the analyses.

Energy Technology Data Exchange (ETDEWEB)

It is shown that a cosmic gamma-ray telescope made of a multilayer silicon tracker and a imaging CsI calorimeter, is capable of identifying cosmic ray nuclei. The telescope charge resolution is estimated around 4% independently of charge. Simulation methods are used to determine the telescope properties for nuclei detection.

Energy Technology Data Exchange (ETDEWEB)

High-spin states in {sup 202}Pb and {sup 203}Pb have been investigated by in-beam {gamma}-ray spectroscopy following the reaction {sup 198}Pt({sup 9}Be,xn). A search for magnetic rotational bands in these isotopes confirmed one of the two bands previously assigned to {sup 202}Pb and revealed a new band in this isotope. No evidence for magnetic rotation has been found in {sup 203}Pb. (orig.)

DEFF Research Database (Denmark)

In 1995 the exercise RESUME-95 (Rapid Environmental Surveying Using Mobile Equipment) took place in Finland. Groups from 8 European countries joined the exercise. The methods used were airborne gamma-ray measurements, car-borne measurements and in situ stationary measurements. The results of the measurements are analyses aiming at disclosing similarities and differences between groups and measuring techniques.

International Nuclear Information System (INIS)

This review briefly describes current efforts to develop superradiant sources of coherent radiation for the sub-nanometer range of wavelenghs, using nuclear rather than the atomic or molecular transitions that are stimulated in existing lasers. First the radiative (including Raman) interactions of nuclei with those of atoms and molecules are compared; then the present status of research on the fundamental problems involved in stimulating nuclear gamma radiation is described. (author). 20 refs.; 2 figs.

International Nuclear Information System (INIS)

Detailed level schemes, decay schemes, and the experimental data on which they are based are presented for all nuclei with mass numbers A -- 216, 220, 224, and 228. The experimental data are evaluated; inconsistencies and discrepancies are noted; and adopted values for level and #gamma#-ray energies, #gamma# intensities, as well as for other nuclear properties are given.

International Nuclear Information System (INIS)

Levels in "7"2Se were observed via in-beam gamma spectroscopy following the "5"8Ni("1"6O,2p) reaction. Spectra and partial energy level schemes are shown. (3 figures) (U.S.).

International Nuclear Information System (INIS)

The gamma scanning system which is installed in IMEF is the equipment obtaining the gamma ray spectrum from irradiated fuels. This equipment could afford the useful data relating spent fuels like as burn-up measurements. We describe the specifications of the equipment and its accessories, and also described its operation procedure so that an operator can use this report as the operation procedure. (author). 1 tab., 11 figs., 11 refs.

International Nuclear Information System (INIS)

Natural radioactive materials were used for detector calibration. We found that KCl is a very suitable material for this purpose. The efficiency curve shape was derived by using #gamma# ray lines of "2"1"4Bi normalised using a known quantity of KCl in the same geometry. The best fit was found by the least squares method. The summing correction coefficients for "2"1"4Bi are determined. (orig.).

Science.gov (United States)

Thesis. Five-particle shell-model calculations, using a spin-dependent potential, were performed for the nucleus /sup 101/Tc. The effects of varying the single-particle energy differences and the strengths of the spin-dependent and pairing terms are discussed. The isobars /sup 101/Mo and /sup 101/Tc were chemically separated to enable the detailed study of their decay schemes. As a result, 184 gamma rays were observed in the decay of /sup 101/Mo, and 169 of them were assigned to 45 levels in /sup 101/Tc. In the decay of /sup 101/Tc, 27 gamma rays were observed, and 26 of them were assigned to 11 levels in /sup 101/Ru. In a study of the decays of /sup 142/Xe and /sup 142/Cs the TRI STAN on-line isotope separator was used to separate the 142 mass chain produced in /sup 235/U fission with /sup 142/2Xe as the emanating and accelerated nuclide. Isobaric separation of /sup ...

International Nuclear Information System (INIS)

The crabbing of an incident photon beam from a laser, and the electron beam with which it interacts at the conversion point, is shown to have the same efficiency as in head-on Compton scattering, but with the advantages of a crossing geometry. The resulting #gamma#-ray beam is also crabbed, which allows for a crossing collision point, while maintaining the luminosity at the same value it would have in a head-on collision.

International Nuclear Information System (INIS)

The crabbing of an incident photon beam from a laser, and the electron beam with which it interacts at the conversion point, is shown to have the same efficiency as in head-on Compton scattering, but with the advantages of a crossing geometry. The resulting #gamma#-ray beam is also crabbed, which allows for a crossing collision point, while maintaining the luminosity at the same value it would have in a head-on collision. ((orig.)).

International Nuclear Information System (INIS)

A high resolution Compton telescope has been identified by the Gamma Ray Astronomy Program Working Group (GRAPWG) as the highest priority major mission in gamma ray astrophysics following GLAST. This mission should provide 25-100 times improved sensitivity, relative to CGRO and INTEGRAL, for MeV gamma ray lines. It must have good performance for narrow and broad lines and for discrete and diffuse emissions. Several instrumental approaches are being pursued to achieve these goals. We discuss issues relating to this mission including alternative detector concepts, instrumental configurations, and background reduction techniques. We have pursued the development of position-sensitive solid-state detectors (Ge, Si) for a high spectral resolution Compton telescope mission. A #approx#1 m2 germanium Compton telescope of position-sensitive germanium detectors was the ...

Energy Technology Data Exchange (ETDEWEB)

A comparison of maximum likelihood (or chi-square) and Bayesian peak fitting techniques shows that the latter can reduce peak intensity uncertainties by a factor of up to ten in the case of closely separated doublets, leading to greatly improved doublet resolution. The need for laboratories to demonstrate the reliability of their chosen peak fitting techniques and measures of peak intensity is also demonstrated. (orig.)

International Nuclear Information System (INIS)

The advance in the analysis of very small amount (<= 1#alpha#/cm"2h) of #alpha#-emitters in the cited materials is reviewed. The review, for which 75 references are listed, covers the period from January, 1978, to June, 1982. The use of #alpha#-ray counting, #alpha#-ray spectrometry, #gamma#-ray spectrometry, neutron activation analysis and mass spectrometry is discussed, and their relative merit and limitation are outlined. (J.P.N.).

International Nuclear Information System (INIS)

In the fields of medical imaging, geophysical well logging, and industrial radiography, it is often of interest to characterize the spatially distributed sensitivities of neutron and gamma-ray measurement devices to the physical properties of the materials being examined. For instance, one may wish to know how the count rate in a detector varies in response to small changes in the local density of the irradiated object as a function of position. Experimental determination of such sensitivity functions is often impractical. Consequently, we have developed a general three-dimensional Monte Carlo numerical technique that allows us to directly compute the differential sensitivity of an arbitrary integral response parameter, such as a time- or energy-discriminated count rate, with respect to the spatial distribution of macroscopic cross sections and sources in the irradiated medium. Sensitivities to object density, porosity, etc., can easily be derived from these ...

DEFF Research Database (Denmark)

Investigations into sexual differentiation and pheromone response in the fission yeast Schizosaccharomyces pombe are complicated by the need to first starve the cells of nitrogen. Most mating-related experiments are therefore performed on non-dividing cells. Here we overcome this problem by using two mutants that bypass the nutritional requirements and respond to the M-factor mating pheromone in rich medium. The first mutant lacks the cyr1 gene which encodes adenylate cyclase and these cells contain no measurable amounts of cAMP. When M-factor is added to a growing h+ cyr1- strain it causes a transient G1 arrest of cell division, transcription of mat1-Pm, and elongation of the cells to form shmoos. The second mutant contains the temperature-sensitive pat1-114 allele. At 30 degrees C this mutant was previously shown not only to bypass the nutritional signal but also to stop growing in a state derepressed for pheromone-controlled functions. We now report that an h+ pat1-114 strain ...

International Nuclear Information System (INIS)

Chemical analyses were done on the abnormal hemoglobins of the five (101 x SEC)F_1 offspring of X- irradiated adult SEC mice to determine which hemoglobin genes were expressed in each hemoglobin variant. Three offspring of irradiated SEC males did not express either of the two kinds of #alpha#-chains normally found in all SEC mice. The deficient #alpha#-chain synthesis caused these mice to exhibit an #alpha#-thalassemia similar to human #alpha#-thalassemia. Scanning electron microscopy was used to show that many erythrocytes of mice with #alpha#-thalassemia have bizarre shapes; e.g. many erythrocytes appeared flattened or had thorny projections (acanthocytes). One mutant with a tandem duplication of a segment of chromosome 7 (site of locus determining #beta#-chain structure) produced twice as much SEC as 101 #beta#-chain polypeptides. One mutant that probably arose by non-disjunction of chromosome 7's in its unirradiated 101 mother and loss of chromosome 7 from the gamete of its ...

Energy Technology Data Exchange (ETDEWEB)

The malM locus of Streptococcus pneumoniae was cloned into one of the two PstI sites of the multicopy S. pneumoniae plasmid pMV158. To eliminate chromosomal transformants in the simultaneous selection for tetracycline resistance (coded by pMV158) and maltose utilization, the host cells contained a chromosomal deletion of the mal gene cluster. Two clones were isolated; one with a 3.3 kb insert (pLS70) which behaved like wild type with respect to maltose utilization, and another with a 2.9 kb insert (pLS69) which behaved as though it contained a down promoter mutation. Preliminary mapping of these clones by restriction analysis placed the 0.4kb deletion on a HindIII fragment in the interior of the chromosomal insert. The recombinant plasmids were able to transform over 50% of a recipient population to Mal/sup +/. Enzyme measurements of the clones indicated an overproduction of amylomaltase, constituting up to 10% of the total cellular protein, and supported the ...

UK PubMed Central (United Kingdom)

Receptor protein tyrosine phosphatase T (PTPRT/PTPρ) is frequently mutated in human cancers including colon, lung, gastric and skin cancers. More than half of the identified tumor-derived...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo report unusual ocular manifestations of branchio-oculo-facial syndrome (BOFS) caused by a novel mutation in activating enhancer binding protein 2 alpha (TFAP2A).MethodsFull...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo investigate whether acquired somatic mutations in the iron response element of the ferritin L-chain gene account for the age-related cataract.MethodsThe...Full Text Available

UK PubMed Central (United Kingdom)

Recent preclinical and clinical data suggest that TP53 status and TP53 mutations may be important in determining tumour aggressiveness and therapy response. In this study we investigate the feasibility...Full Text Available

UK PubMed Central (United Kingdom)

Fast and efficient high-throughput techniques are essential for the molecular diagnosis of highly heterogeneous hereditary diseases, such as retinitis pigmentosa (RP). We had previously approached RP...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundSLC19A3 (solute carrier family 19, member 3) is a thiamin transporter with 12 transmembrane domains. Homozygous or compound heterozygous mutations in SLC19A3 cause...Full Text Available

UK PubMed Central (United Kingdom)

Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the second most common cause of early-onset dementia. Mutations in the progranulin gene are a major cause of familial...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundGene mutation is an important mechanism of myeloid leukemogenesis. However, the number and combination of gene mutated in myeloid malignancies is still a matter of investigation.MethodsWe...Full Text Available

CERN Document Server

It is widely accepted that the prompt transient signal in the 10 keV - 10 GeV band from gamma-ray bursts (GRBs) arises from multiple shocks internal to the ultra-relativistic expansion. The detailed understanding of the dissipation and accompanying acceleration at these shocks is a currently topical subject. This paper explores the relationship between GRB prompt emission spectra and the electron (or ion) acceleration properties at the relativistic shocks that pertain to GRB models. The focus is on the array of possible high-energy power-law indices in accelerated populations, highlighting how spectra above 1 MeV can probe the field obliquity in GRB internal shocks, and the character of hydromagnetic turbulence in their environs. It is emphasized that diffusive shock acceleration theory generates no canonical spectrum at relativistic MHD discontinuities. This diversity is commensurate with the significant range of spectral indices discerned in prompt burst ...

International Nuclear Information System (INIS)

The decay of "1"0"1Mo to levels in "1"0"1Tc has been studied using the three-parameter (#gamma#-#gamma#-t) coincidence system of HpGe-HpGe detectors. According to the coincidence data, the decay scheme was modified. The positions of 221.80, 318.00, 377.90, 452.50, 515.42, 1011.05 and 1759.72 keV transitions have been arranged again, the transition positions of 104.70, 105.95 and 774.15 keV gamma-rays have been assigned for the first time, the positions of 169.00, 590.91, 980.52 and 1431.68 keV transitions have been reconfirmed, the 1508.01 keV gamma-ray was observed simultaneously for the first time and its transition position has been assigned. The #beta#-intensities and the values of log ft of most levels were calculated. (author)

Energy Technology Data Exchange (ETDEWEB)

The goal of this DOE-supported exhibition is to demystify Einstein`s formula E = mc{sup 2} by illustrating the interchangeability of matter (m) and energy (E), c{sup 2} being the exchange rate. The exhibition has two major parts, {open_quotes}matter into energy{close_quotes} and {open_quotes}energy into matter{close_quotes}, plus a video to connect them. {open_quotes}Matter into energy{close_quotes} has now been completed and has been placed on the museum floor. Positrons from a {sup 22}Na source are annihilated to produce gamma rays that are caught in NaI detectors. The viewer can alter the alignment of the detectors and observe the consequences for the rates of single and coincident counts. The viewer can also observe the effects of placing absorbers in front of the counters. Prototype explanatory graphics were placed around the exhibit and those will probably be changed after we have some experience with their effectiveness. The connecting ...

CERN Document Server

We report on the spectral cross-calibration results of the Konus-Wind, the Suzaku/WAM, and the Swift/BAT instruments using simultaneously observed gamma-ray bursts (GRBs). This is the first attempt to use simultaneously observed GRBs as a spectral calibration source to understand systematic problems among the instruments. Based on these joint spectral fits, we find that 1) although a constant factor (a normalization factor) agrees within 20% among the instruments, the BAT constant factor shows a systematically smaller value by 10-20% compared to that of Konus-Wind, 2) there is a systematic trend that the low-energy photon index becomes steeper by 0.1-0.2 and Epeak becomes systematically higher by 10-20% when including the BAT data in the joint fits, and 3) the high-energy photon index agrees within 0.2 among the instruments. Our results show that cross-calibration based on joint spectral analysis is an important step to understanding the instrumental effects which ...

CERN Document Server

Cadmium telluride (CdTe) and cadmium zinc telluride (CdZnTe) have been regarded as promising semiconductor materials for hard X-ray and Gamma-ray detection. The high atomic number of the materials (Z_{Cd} =48, Z_{Te} =52) gives a high quantum efficiency in comparison with Si. The large band-gap energy (Eg ~ 1.5 eV) allows us to operate the detector at room temperature. However, a considerable amount of charge loss in these detectors produces a reduced energy resolution. This problem arises due to the low mobility and short lifetime of holes. Recently, significant improvements have been achieved to improve the spectral properties based on the advances in the production of crystals and in the design of electrodes. In this overview talk, we summarize (1) advantages and disadvantages of CdTe and CdZnTe semiconductor detectors and (2) technique for improving energy resolution and photopeak efficiencies. Applications of these imaging detectors in future hard X-ray and ...

CERN Document Server

The main LHC superconducting magnets (dipoles and quadrupoles) use Rutherford type cables, stabilized electrically and thermally with copper profiles. The portions of cables are connected to each other by a soft soldering technique (Sn96Ag4) with an overlapping length corresponding to one pitch of the superconducting strands. The splice constitutes a "composite" structure with the interchanging layers of Sn96Ag4 and NbTi superconductor, located inside a Cu cage. In order to ensure a high level of reliability (failure probability not exceeding 10-8) for some 10000 connections in the LHC, a non-destructive technique to check the quantity of solder in the joint is foreseen. The technique is based on a gamma ray source (241Am) and the detection is position-sensitive in the transmission mode. Scintillating detectors of gamma rays are used and their accumulated length corresponds to the length of the ...

International Nuclear Information System (INIS)

Molar extinction coefficients of some commonly used solvents (ethanol (C_2H_5OH), methanol (CH_3OH), propanol (C_3H_7OH), butanol (C_4H_9OH), water (H_2O), toluene (C_7H_8), benzene (C_6H_6), carbontetrachloride (CCl_4), acetonitrile (C_4H_3N), chlorobenzene (C_6H_5Cl), diethylether (C_4H_1O) and dioxane (C_4H_8O_2)) have been determined by a well-collimated narrow beam transmission geometry at 279, 356, 662, 1173, 1252 and 1332 keV #gamma# rays. The total #gamma# ray interaction cross sections of these solvents have also been determined. A good agreement has been obtained between the experimental results with the theoretical values evaluated through XCOM calculations.

Energy Technology Data Exchange (ETDEWEB)

The measurements of the K X-ray intensity ratio I(K{alpha} {sub 2}/K{alpha} {sub 1}), I(K{beta} {sub 1}/K{alpha} {sub 1}) and I(K{beta}/K{alpha}) for elements V, Mn, Zn, Tc, Ru, Cd, Xe, Ba, Cs, Hg and Rn were experimentally determined both by photon excitation, in which 59.5 keV {gamma}-rays from a {sup 241}Am and 123.6 keV {gamma}-rays from a {sup 60}Co were used, and following the radioactive decay of {sup 51}Cr, {sup 55}Fe, {sup 67}Ga, {sup 99}Tc, {sup 111}In, {sup 131}I, {sup 133}Ba, {sup 133}Xe, {sup 137}Cs, {sup 201}Tl and {sup 226}Ra. K X-rays emitted by samples were counted by a Si(Li) detector with resolution 160 eV at 5.9 keV. Obtained values were compared with the theoretical values. It was observed that present values agree with the previous theoretical and other experimental results.

International Nuclear Information System (INIS)

Seven types of shellfish were irradiated by gamma ray at doses of 0, 3 and 6 kGy. Pulse photo-stimulated luminescence (PPSL) and thermoluminescence (TL) methods were employed to detect the radiation treatment. The screening of irradiation was carried out by the PPSL method followed by identification using the TL technique. Most of the irradiated shellfish were screened out correctly and only a few showed photon counts a bit higher than the lower threshold value by much lower than the upper threshold value. The TL method was employed using minerals isolated from all the control and irradiated shellfish samples by density gradient treatment. Three parameters, integrated intensities of first glow curves (TL1), ratios of first to that of second glow curves (TL1/TL2), and the shapes of maxima of first glow curves, were utilized for the identification of gamma ray treatment of shellfish. (author)

CERN Document Server

Gamma-ray burst (GRB) is one of the candidates of high-energy cosmic-ray acceleration sites. They may be also ultra-high-energy (above 3 EeV) cosmic-ray (UHECR) sources. In this paper, we discuss possibilities and implications of high-energy cosmic-ray acceleration in GRBs. (1) First, we show that not only protons but also heavier nuclei can be accelerated up to ultra-high energies in both usual high-luminosity (HL) and low-luminosity (LL) GRBs by using the Geant4. LL GRBs may also make a significant contribution to the observed UHECR flux if they form a distinct population, and we investigate cosmic-ray acceleration in LL GRBs in detail. (2) Second, we discuss implications of the GRB-UHECR hypothesis (and Hypernova-UHECR hypothesis) to cosmic-ray astronomy. HL GRBs and LL GRBs will lead to different source number densities as UHECR sources, so that the determination of the number density of UHECR sources and strength of the mean extragalactic magnetic field (EGMF) ...

International Nuclear Information System (INIS)

A laminated material composed of glass cloth/polyimide film/epoxy resin will be used as an insulating material for superconducting coil of International Thermonuclear Experimental Reactor (ITER). In order to keep safe and stable operation of the superconducting coil system, it is indispensable to evaluate radiation resistance of the material, because the material is exposed to severe environments such as high radiation field and low temperature of 4 K. Especially, it is important to estimate the amount of gases evolved from the insulating material by irradiation, because the gases affect on the purifying system of liquid helium in the superconducting coil system. In this work, the gas evolution from the laminated material by gamma ray irradiation at liquid nitrogen temperature (77 K) was investigated, and the difference of gas evolution behavior due to difference of composition in the epoxy resin was discussed. It was found that the main gases ...

CERN Document Server

The true nature of the progenitor to GRBs remains elusive; one characteristic that would constrain our understanding of the GRB mechanism considerably is gamma-ray polarimetry measurements of the initial burst flux. We present a method that interprets the prompt GRB flux as it Compton scatters off the Earth's atmosphere, based on detailed modelling of both the Earth's atmosphere and the orbiting detectors. The BATSE mission aboard the \\textit{CGRO} monitored the whole sky in the 20 keV - 1 MeV energy band continuously from April 1991 until June 2000. We present the BATSE Albedo Polarimetry System (BAPS), and show that GRB 930131 and GRB 960924 provide evidence of polarisation in their prompt flux that is consistent with degrees of polarisation of $\\Pi>35$% and $\\Pi>50$% respectively. While the evidence of polarisation is strong, the method is unable to strongly constrain the degree of polarisation beyond a systematics based estimation. Hence the ...

International Nuclear Information System (INIS)

The rates of hydrogen release from simulated high-level liquid waste (SHLLW) during irradiation of "6"0Co #gamma#-rays have been studied using a laboratory-scale apparatus. The SHLLW used was made up of 28 different metal elements, the concentrations of which were determined from a computed data (ORIGEN-2) for a Purex spent fuel (burn-up of 4.5 GWd/t, cooling time of 4 years) except for those of corrosion products (Fe, Cr and Ni) and of chemical process additive (P). The nitrate ion concentration of the SHLLW was 4.97 M. The G-value of hydrogen release was 0.0164 for stirred conditions, but for nonstirred conditions with dose rate : 2.8 kGy/h and with the SHLLW solution height more than 8 cm, the following relation was found between the G-value and the solution height (d cm); G(H_2) = 0.100 d"-"1"."6. The G-values of oxygen and nitrogen releases were also determined. (author).

International Nuclear Information System (INIS)

The X-band EPR spectra of unirradiated and "6"0 Co gamma ray irradiated cardamom (Elettaria cardamomum L. Maton, Zingiberaceae), ginger ((Zingiber officinale Rosc., Zingiberaceae), saffron (Crocus sativus L., Iridaceae), and curry have been investigated at room temperature. All unirradiated spices presented a weak resonance line with g-factors around free-electron ones, most probably due to the presence of semiquinones, previously reported to have paramagnetic properties. After gamma ray irradiation at absorbed dose up to 11.3 kGy we have noticed in all spices the presence of complex EPR spectra consisting of a superposition of at last two different paramagnetic species whose amplitude increase monotonously with the absorbed dose. A 100 deg. C isothermal annealing of 11.3 kGy irradiated samples has shown a differential reduction of amplitude of various components that form the initial spectra, but even ...