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Pregnant rats in 11d and 16d of their pregnancy were given one-off whole body exposure by "1"3"7Cs #gamma# rays to 0.2, 0.4, 0.9 and 2.0 Gy, respectively. Changes were observed in conditioned drinking response and cerebrum hippocampi cone cell number of the baby rats exposed to the #gamma# rays in different periods of their embryo development. As a result, that pregnant rats exposed to "1"3"7Cs #gamma# rays in different pregnant periods may induce significant decrease in cerebrum hippocampi cone cell number and achieving rate of conditioned drinking response of the babies. The dose-response relationship can be described by Y=a-b log_1_0D. The achieving rate of conditioned drinking response were significantly correlated to cerebrum hippocampi cone cell number in the babies, and the achieving rate of conditioned drinking response of the babies exposed at pregnant ...

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Diethyldithiocarbamate (DDTC), a chelating agent, is an active metabolite of disulfiram (Antabus) and is used in the rubber industry. The effect of DDTC on the tissue distribution of "2"0"3Pb was studied in rats. Two groups of rats were given an i.v. injection of 100 #mu#Ci "2"0"3Pb (28.6 nmol/kg b.wt.) as lead acetate. After 10 min one group received 2 mmol/kg b.wt. of DDTC as an i.p. injection. Rats were killed 4 and 72 h after injection of "2"0"3Pb and tissue concentration and excretion of "2"0"3Pb was determined by gamma counting. The brain concentration of "2"0"3Pb in DDTC-treated rats was nine times higher than in controls after 4 h and 14 times higher after 72 h. Treatment with DDTC also increased the lead concentration in fat about seven times at both survival intervals. On the other hand, uptake of "2"0"3Pb in bone was reduced by treatment with DDTC and at 4 h also kidney ...

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Intact rat fat cell exposed to 12.5 ..mu..M (..gamma..-32P)ATP incorporate label into specific proteins within minutes. By solubilizing the reaction mixture with SDS which bypasses the subcellular fractionation steps, the labeled proteins can be identified in autoradiographs of SDS-PAGE gels. The most prominently labeled protein has an M/sub r/ of 42,000. Localization of this component to the cell surface can be made on the basis of inhibition of phosphorylation by addition of a protein derived from the rat brain with protein kinase inhibitory property, susceptibility of the phosphorylated protein to the tryptic digestion, inhibition of phosphorylation of this protein after brief exposure to melittin. To rule out the possibility that the cell surface protein might be a mitochondrial contaminant from broken cells, /sup 32/Pi-labeled and (..gamma..-/sup 32/P)ATP-labeled cells were chromatographed on a ...

International Nuclear Information System (INIS)

Introduction: Development of agonist positron emission tomography (PET) radioligands for the 5-HT neurotransmitter system is an important target to enable the understanding of human 5-HT function in vivo. ["1"1C]CUMI-101, proposed as the first 5-HT_1_A receptor agonist PET ligand, has been reported to behave as a potent 5-HT_1_A agonist in a cellular system stably expressing human recombinant 5-HT_1_A receptors. In this study, we investigate the agonist properties of CUMI-101 in rat brain tissue. Methods: ["3"5S]-GTP#gamma#S binding studies were used to determine receptor function in HEK (human embryonic kidney) 293 cells transfected with human recombinant 5-HT_1_A receptors and in rat cortex and rat hippocampal tissue, following administration of CUMI-101 and standard 5-HT1A antagonists (5-HT, 5-CT and 8-OH-DPAT). Results: CUMI-101 behaved as an agonist at human recombinant 5-HT_1_A receptors (pEC_5_0 ...

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The authors have used limited proteolysis of affinity-labeled estrogen receptors (ER), coupled with antireceptor antibody immunoreactivity, to assess structural features of ER and the relatedness of ER from MCF-7 human breast cancer and rat uterine cells. MCF-7 ER preparations covalently labeled with ["3H]tamoxifen aziridine (["3H]TAZ) were treated with trypsin (T), #alpha#-chymotrypsin (C), or Staphylococcus aureus V8 protease prior to electrophoresis on sodium dodecyl sulfate gels. Fluorography revealed a distinctive ladder of ER fragments containing TAZ for each protease generated from the M/sub r/ 66,000 ER. Immunoblot detection with the primate-specific antibody D75P3#gamma# revealed that all immunoreactive fragments corresponded to TAZ-labeled fragments but that some small TAZ-labeled fragments were no longer immunoreactive. In contrast, use of the antibody H222SP#gamma# revealed a correspondence between TAZ-labeled ...

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The production of three vector bosons in #gamma# #gamma# collisions studying the reactions #gamma# + #gamma# #-># W"+ + W"- + Z"0 and #gamma# + #gamma# #-># W"+ + W"- + #gamma#. 12 refs., 4 figs., 2 tabs.

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Iron deficiency did not enhance absorption of plutonium following intragastric gavage of rats. Absorption of plutonium citrate in both control and iron-deficient rats was about 0.03% of the administered dose.

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Udgivelsesdato: 1995-Nov

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$\\gamma/\\phi_3$ at hadron colliders

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It is proposed to measure the spot sizes and polarization of #gamma# beams of future #gamma#e and #gamma##gamma# colliders detecting e"+e"- pairs produced as a result of interaction of high energy #gamma# quanta with density modulated and not modulated laser photons. The quantum electrodynamics cross sections, necessary numerical results as well as a short comparison of the proposed method with some other methods are given. (orig.).

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A comparative and quantitative study of the tissue distribution of brain-thymus shared antigens was carried out using rabbit antisera to rat, dog and human brain homogenates, assayed on rat, dog and...Full Text Available

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AIMS:To investigate the effect of carnitine supplementation on alcoholic malnourished rats' hepatic nitrogen content.METHODS:Malnourished rats, on...Full Text Available

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Wistar rats with streptozotocin-induced diabetes (STZ-diabetic rats), which is similar to human insulin-dependent diabetic mellitus (IDDM), were employed to investigate...Full Text Available

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The authors study the processes {gamma}e {r{underscore}arrow} {gamma}e and {gamma}{gamma} {r{underscore}arrow} {gamma}{gamma}, in the context of the proposal for Weak Scale Quantum Gravity (WSQG) with large extra dimensions. With an ultraviolet cutoff M{sub S} {approximately} 1 TeV for the effective gravity theory, the cross sections obtained for these processes at the Next Linear Collider (NLC), with the e{gamma} an {gamma}{gamma} options, deviate from the predictions of the Standard Model significantly. The results suggest that, for typical proposed NLC energies and luminosities, the predictions of WSQG can be tested in the range 1 TeV {approx{underscore}lt} M{sub S} {approx{underscore}lt} 10 TeV, making e{gamma} an {gamma}{gamma} colliders important tools for probing WSQG.

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The objective of this study was to evaluate how the vehicles of choice affect the pharmacokinetics of orally administered Fluoranthene [FLA] in rats. Fluoranthene is a member of the family of...Full Text Available

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Copper deficiency is associated with impaired brain development and mitochondrial dysfunction. Perinatal copper deficiency was produced in Holtzman rats. In vivo proton NMR...Full Text Available

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... electrophoresis fission products gamma radiation gamma spectra half-life

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Three possibilities to observe the Higgs-top interaction at future #gamma##gamma#-colliders are discussed: a) associated Higss production via the #gamma##gamma##->#tanti tH reaction, b) Higgs obliged radiative correction to the #gamma##gamma##->#tanti t channel, c) Higgs resonance production via #gamma##gamma##->#H#->#ZZ. The results obtained show windows of the Higss mass where the Yukawa interaction of the Higss with the top quark can be studied at #gamma##gamma#-colliders. (orig.).

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The symmetrical complexes [{sup 99m}Tc][TcN(R{sub 2}PS{sub 2}){sub 2}] [R = CH{sub 3}, CH{sub 2}CH{sub 3}, CH{sub 2}CH{sub 2}CH{sub 3}, CH{sub 2}(CH{sub 3}){sub 2}], and the unsymmetrical complex [{sup 99m}Tc][TcN(Me{sub 2}PS{sub 2})(Et{sub 2}PS{sub 2})] have been prepared, at tracer level, through a two-step procedure involving the preliminary formation of a prereduced technetium nitrido intermediate followed by substitution reaction onto this species by the appropriate dithiophosphinate ligand [R{sub 2}PS{sub 2}]Na. The chemical identity of the resulting complexes have been established by comparison with the corresponding {sup 99}Tc-analogs prepared, at macroscopic level, by reacting the complex [{sup 99}TcNCl{sub 4}] [n-Bu{sub 4}N] (n-Bu = n-butyl) with an excess of ligand in methanol, and characterized by elemental analyses and spectroscopic techniques. The complexes are neutral and lipophilic, and possess a square pyramidal geometry, with an apical Tc N group and two ...

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The effect of experimental diabetes on the phosphorylation of proteins in the rat sciatic nerve was studied. Nerves from animals made diabetic with streptozocin were incubated in vitro with (/sup 32/P)orthophosphate and divided into segments from the proximal to the distal end, and proteins from each segment were then separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The principal labeled species were the major myelin proteins, P0, and the basic proteins. After 6 wk of diabetes, the incorporation of isotope into these proteins rose as a function of distance along the nerve in a proximal to distal direction and was significantly higher at the distal end compared with incorporation into nerves from age-matched controls. The overall level of isotope uptake was similar in nerves from diabetic animals and weight-matched controls. The distribution of /sup 32/P among proteins also differed in diabetic nerve compared with both control groups in that ...

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Twenty-four male weanling rats were fed either copper-adequate or -deficient diets until 9 or 11 weeks of age. Deficient rat hearts had increased mitochondria: myofibril compared to adequate rats. Eleven week old deficient rat hearts had decreased mitochondria: myofibril as the hearts increased in weight, but the larger hearts had greater myofibril volume densities. Cardiac mitochondria of deficient rats appeared vacuolated with fragmented cristae and translucent matrix. Valves from copper deficient rats appeared to have less connective tissue and were fragmented in areas. For deficient rats, heart:body weights of 9 wk old rats were negatively correlated with bicuspid valve pathology scores, whereas tricuspid valve scores from 11 wk old rats were negatively correlated with myofibril volume densities. ...

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The myocardial infarct induced by isoproterenol in spontaneously hypertensive rats accumulates higher activities of /sup 99/sup(m)Tc-PM tetracycline compared with the cardiac infarct in normotensive rats caused by the same method. The isoproterenol model of the myocardial necrosis was induced in intact rats without opening the thorax and is a convenient method for experimental radioisotope studies.

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The purpose of this study was to evaluate the toxicological effects of feeding the oils of Calophyllum inophyllum, Pentaclethra macrophylla and Terminalia catappa to rats. The effects on physical appearance, feed intake, weight gain, plasma and tissue cholesterol and triacyglycerol levels in rats with 5% of the oils in normal rat feed were determined. Weekly monitoring of the rats showed good physical appearance and steady weight gain, with no mortality recorded for the period of the study. Haematological analysis of the rats indicated that they were not anaemic. Histopathotogical examination of the sections of the heart, liver, kidney and spleen revealed moderate (T. catappa oil) to severe fatty change and necrosis in the liver. Glomerulonephrotic changes in the kidneys of rats fed with T...

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To examine the hormonal regulation of the ATP-dependent Ca{sup 2+} pump in the kidneys, the ATP-dependent Ca{sup 2+} uptake by the basolateral membrane vesicles in the renal cortex was measured using radioactive calcium ({sup 45}Ca{sup 2+}) in rats with vitamin D deficiency or rats undergoing thyroparathyroidectomy. The V{sub max} of the Ca{sup 2+} pump activity was increased not only by administering calcitriol, but also by normalizing the serum calcium level in vitamin D-deficient rats. PTH suppressed the Ca{sup 2+} pump activity in normocalcemic vitamin D-deficient rats. Thyroparathyroidectomy did not affect the Ca{sup 2+} pump activity in the kidneys of normal rats. It was concluded that the ATP-dependent Ca{sup 2+} pump activity was depressed by secondary hyperparathyroidism in vitamin D-deficient rats. (author).

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Future linear colliders offer unique opportunities to study {gamma}{gamma}, {gamma}e interactions. Using the laser backscattering method one can obtain {gamma}{gamma}, {gamma}e colliding beams with energy and luminosity comparable to the electron-position luminosity or even higher. In this review physical principles of photon colliders are described and various problems, concerning the accelerator, laser, interaction region and luminosity are discussed. Some examples of physical processes are given. ((orig.)).

International Nuclear Information System (INIS)

Inhaled beryllium oxide results in impaired alveolar clearance of inhaled "2"3"9PuO_2 and induces an inflammatory reaction in the lung. However, only one of 184 rats exposed to beryllium developed a lung tumor; none of 128 unexposed rats developed a lung tumor. Fifty-six lung tumors were induced in 181 rats exposed to plutonium. A total of 37 lung tumors were found in 119 rats given combined exposures to beryllium and plutonium. Only in rats given the highest levels of both beryllium and plutonium was there an incidence of lung tumors greater than that seen with exposure to plutonium only.

International Nuclear Information System (INIS)

The angular #gamma##gamma#-correlations for nuclei of Sr even-even isotopes with a=8 82, 84, 86, 88 were measured. Multipole structurs of #gamma#-transtion series and th coefficients multipole mixing were determined.

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We present methods to measure the beam polarizations and the luminosity of [gamma][gamma] colliders at TeV energy scale. The beam polarizations of a [gamma][gamma] collider can easily be monitored by comparing the numbers of events of the processes [gamma][gamma] [yields] l[sup +]l[sup -] and [gamma][gamma] [yields] W[sup +] W[sup -], where l means e or [mu]. The luminosity of a [gamma][gamma] collider is also measurable by the event rate of W boson pair productions and the light lepton pair productions. (orig.)

International Nuclear Information System (INIS)

In this talk I briefly summarize different models for #sigma#_2_#gamma#"t"o"t (e"+e"-#->##gamma##gamma##->#hadrons) and contrast model predictions with the data. I will then discuss the capability of the future e"+e"- and #gamma##gamma# colliders to distinguish between various models and end with an outlook for future work.

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A #gamma##gamma# collider would extend and complement the physics capability of a linear collider; e.g. it would be suitable for direct measurement of the partial decay width of a Higgs boson into two gamma quanta. This paper discusses choice of laser parameters, luminosity optimization, electron and laser parameters for a gamma- gamma collider as a second interaction region for the Next Linear Collider, laser path, and the lasers. It is concluded that a gamma- gamma collider is technically feasible; however it will require a significant investment in preparatory R ampersand D.

International Nuclear Information System (INIS)

We investigate the chargino production process #gamma##gamma# #-># (W-tilde)"+(W-tilde)"- at high energy #gamma##gamma# colliders in the framework of the minimal supersymmetric standard model (MSSM). Here the high energy #gamma# beams are obtained by the backward Compton scattering of the laser flush by the electron in the basic linear TeV ee colliders. We consider the polarization of the laser photons as well as the electron beams. Appropriate beam polarization could be effective to enhance the cross section to for us extract the signal from the dominant background #gamma##gamma# #-># W"+W"-. (author).

International Nuclear Information System (INIS)

To determine a rat strain appropriate for carcinogenicity testing of FYX-051, a xanthine oxidoreductase inhibitor, we performed a 4-week oral toxicity study by administering 0.3, 1 and 3 mg/kg, and 1, 3 and 10 mg/kg of FYX-051 to male Sprague-Dawley (SD) and Fischer (F344) rats, respectively. Histopathology revealed that the degree of FYX-051-induced nephropathy was 3-fold stronger in SD rats than in F344 rats. Our previous study demonstrated that the key factor of species differences in FYX-051-induced nephropathy is purine metabolism. This observation led us to examine the involvement of purine metabolism in differences among two strains of rats. However, purine metabolism was proven not to be implicated as an important factor. Subsequently, other factors responsible for the strain differences were examined. FYX-051-induced increases in plasma xanthine concentrations were higher ...

UK PubMed Central (United Kingdom)

Pituitary Fshb concentrations increase markedly and selectively beginning on Postnatal Day 20 in the male rat. To evaluate the factors potentially responsible for this rise...Full Text Available

UK PubMed Central (United Kingdom)

Cervical spinal cord hemisection rostral to the phrenic nucleus leads to paralysis of the ipsilateral hemidiaphragm in adult rats. Respiratory function can be restored to the paralyzed hemidiaphragm...Full Text Available

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The actions of nicotine, hexamethonium, and ethanol on the hypothalamo-hypophysial system have been investigated in the rat. The antidiuretic action of nicotine was not inhibited by ethanol, nor by...Full Text Available

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1. Sacs 20 cm long were obtained from the upper half of the small intestine of bile fistula rats (bile duct cannulated 48 hours previously). The sacs were everted, filled with oxygenated phosphate...Full Text Available

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Recent clinical trials demonstrate that combined oral dosing with estrogen and progestin increases the incidence of breast cancer in post-menopausal women. Similarly, in a rat model system of...Full Text Available

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Separate groups of rats received 500 trials of lever-press training under autoshaping (food delivery followed 10-second lever presentations, or occurred immediately following a response); operant conditioning...Full Text Available

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In all mammals, tissue inflammation leads to pain and behavioral sensitization to thermal and mechanical stimuli called hyperalgesia. We studied pain mechanisms in the African naked mole-rat, an unusual...Full Text Available

UK PubMed Central (United Kingdom)

A retrospective study of the relationship of season to the absorption of radiolead in laboratory rats was performed using data representing 305 animals from 36 experiments over 6 calendar years. Male...Full Text Available

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In anaesthetized rats, extracellular and intracellular recordings were taken from 106 respiratory neurones in the intermediate region of the nucleus ambiguus. We observed unprovoked shortening of expiratory...Full Text Available

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1. Rates and rate coefficients of glucose utilization and replacement were determined with [5-3H]- and [U-14C]-glucose in rats starved for 24h, either conscious or under halothane anaesthesia, in a...Full Text Available

UK PubMed Central (United Kingdom)

Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from...Full Text Available

UK PubMed Central (United Kingdom)

Rat somatotropin (growth hormone) was labelled biosynthetically by incubating anterior pituitary lobes with radioactive amino acids for 24 h in a simple buffered salts medium containing glucose. The...Full Text Available

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Mice and rats are important mammalian models in biomedical research. In contrast to other biomedical fields, work on sexual differentiation of brain and behavior has traditionally utilized comparative...Full Text Available

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BackgroundIn rats, alcohol exposure during the period of rapid brain growth produces long-term changes in the free-running period, photoentrainment and phase-shifting...Full Text Available

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1. The LD₅₀ of iodomethane orally administered to rats is 76mg./kg. body wt. but repeated daily doses of 30–50mg./kg. body wt. are without effect. 2. Oral doses of iodomethane to...Full Text Available

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To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG was...Full Text Available

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Experiments were conducted to determine the dose response of rat bladder urothelium to a range of different single and fractionated intravesicular doses of the carcinogen, N-methyl-N-nitrosourea (MNU)....Full Text Available

UK PubMed Central (United Kingdom)

1. Rates and rate coefficients of glucose utilization and replacement in post-absorptive rats, either conscious or under halothane anaesthesia, were determined in a thermoneutral environment by using...Full Text Available

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1. The excretion of para-aminohippurate (PAH) in the isolated perfused rat kidney was examined over a wide range of perfusate PAH concentrations (15 microM to 6 mM). PAH excretion increased steadily...Full Text Available

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Using 31P-nuclear magnetic resonance, we studied the relationship between myocardial high-energy phosphate content and flux values for the creatine kinase reaction in the living rat under inotropic...Full Text Available

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Changes in RNA synthesis in liver nuclei were observed at different ages and after hypophysectomy and hormone replacement in female Sprague-Dawley rats. As determined by the incorporation of [3H]UMP...Full Text Available

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NG2 chondroitin sulfate proteoglycan is a surface marker of oligodendroglial progenitor cells (OPCs) in various species. In contrast to well-studied rat OPCs, however, we found that purified...Full Text Available

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The suprachiasmatic nucleus (SCN) of the hypothalamus is thought to play a critical role in circadian rhythm generation and entrainment to the light/dark cycle. In adult rats, the SCN shows a circadian...Full Text Available

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1. The effect on rat liver peroxisomal beta-oxidation of feeding diets containing various amounts of dietary oils was investigated. With increasing amounts (5-25%, w/w) of soya-bean oil an apparent,...Full Text Available

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To determine the relative importance of different metabolites of vitamin D in bone growth and development, weanling male rat pups suckled by vitamin D-deficient mothers were given either calcitriol...Full Text Available

UK PubMed Central (United Kingdom)

The Wistar Kyoto (WKY) rat strain is a putative genetic model of comorbid depression and anxiety. Previous research showing increased κ-opioid receptor (KOR)...Full Text Available

UK PubMed Central (United Kingdom)

We present the results of an automated analysis of the morphometry of the pulmonary airway trees of the Sprague Dawley rat. Our work is motivated by a need to inform lower-dimensional mathematical...Full Text Available

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International Nuclear Information System (INIS)

Absorption of ''organically bound'' "2"3"3U and "2"4"1Am from gastrointestinal tracts of adult rats was twice that of the inorganic nitrate form. There was no difference between transport of "2"3"2U and "2"3"3U by adult rats, but "2"3"2U absorption by newborn rats was four times that of "2"3"3U. Absorption of "2"3"8Pu nitrate through the gut of the newborn is relatively insensitive to dose but incorporation in the gut mucosa saturates at high dose levels. Absorption of "2"3"8Pu is greater at 4 hr of age than at 24 hr.

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(1972). Denmark Ekelund, L. Goethlin, J. Henrikson, H. Letter-to-the-

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The collisions of high energy photons produced at an electron-positron collider provide a comprehensive laboratory for testing QCD, electroweak interactions, and extensions of the standard model. The luminosity and energy of the colliding photons produced by backscattering laser beams is expected to be comparable to that of the primary e"+e"- collisions. In this overview, we shall focus on tests of electroweak theory in photon-photon annihilation, particularly #gamma##gamma##->#W"+W"-, #gamma##gamma##->#Higgs bosons, and higher-order loop processes, such as #gamma##gamma##->##gamma##gamma#, Z#gamma# and ZZ. Since each photon can be resolved into a W"+W"- pair, high energy photon-photon collisions can also provide a remarkably background-free laboratory for studying WW collisions and annihilation. We also review high energy #gamma##gamma# tests of quantum chromodynamics, ...

Science.gov (United States)

The experiment was designed to study the effects of sodium pentobarbital on behavioral thermoregulation in rats and mice. Male Sprague-Dawley rats were given intraperitoneal (i.p.) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male CBA/J mice were giv...

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We study the production of three gauge bosons ([ital W][sup +][ital W][sup [minus

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The cross sections of neutral tensor mesons T=a{sub 2}, f, f', ... production in the exclusive {gamma}{gamma}{yields}TT' or semiexclusive {gamma}{gamma}{yields}TX processes (three gluon exchange) in the semihard region s>>vertical stroketvertical stroke>1 GeV{sup 2} are calculated. The relation of investigated processes to the problem of perturbative Odderon is discussed. The possibility of measurements at LEP and at a future {gamma}{gamma}-colliders is discussed too. (orig.).

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... correlation beta-minus decay coincidence spectrometry experimental data

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We analyze spin correlations between top quark and anti-top quark produced at polarized e{sup +} e{sup -} and {gamma}{gamma} colliders. We consider a generic spin basis to find a strong spin correlation. Optimal spin decompositions for top quark pair are presented for e{sup +}e{sup -} and {gamma}{gamma} colliders. We show the cross- section in these bases and discuss the characteristics of results.

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In the framework of the equivalence theorem the one-loop helicity amplitudes and cross section for the double Higgs production process #gamma##gamma##->#HH are calculated. It is shown that the cross section is measurable at TeV #gamma##gamma# colliders and is marginally sensitive to the triple-Higgs variation. (orig.).

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The complementarity of e"+e"- and #gamma##gamma# colliders to discover and explore new physics beyond the Standard Model (SM) is discussed. After briefly surveying a number of various new physics scenarios, we concentrate in detail on signatures for Large Extra Dimensions via the process #gamma##gamma##->#WW.

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Peroxisome proliferator activated receptor-{gamma} (PPAR{gamma}) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR{gamma} ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR{gamma}. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR{gamma} discrimination of various naturally occurring fatty acid derivatives.

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We examined the effect of the trophic protein, nerve growth factor (NGF), on cultures of fetal rat neostriatum and basal forebrain-medial septal area (BF-MS) to define its role in brain development. Treatment of cultures with NGF resulted in an increase in the specific activity of the cholinergic enzyme choline acetyltransferase (CAT) in both brain areas. CAT was immunocytochemically localized to neurons. In the BF-MS, NGF treatment elicited a marked increase in staining intensity and an apparent increase in the number of CAT-positive neurons. Moreover, treatment of BF-MS cultures with NGF increased the activity of acetylcholinesterase, suggesting that the cholinergic neuron as a whole was affected. To begin defining mechanisms of action of NGF in the BF-MS, we detected NGF receptors by two independent methods. Receptors were localized to two different cellular populations: neuron-like cells, and non-neuron-like cells. Dissociation studies with ["1"2"5I]NGF ...

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We investigate the sparticle production processes e#gamma# #-># e tilde(Z tilde)_1 and #gamma##gamma# #-># (f tilde)(f tilde and bar) at high energy e#gamma# and #gamma##gamma# colliders in the framework of the minimal supersymmetric standard model (MSSM). It will be shown that the e#gamma# colliders would be more suitable in searching for the heavy selectrons than ee colliders because of the low mass threshold of the process e#gamma# #-># (e tilde)(Z tilde)_1. We show that the standard background processes e#gamma# #-># #nu#W and eZ can be suppressed in terms of initial beam polarization as well as the kinematical cuts on the energy and angle of the final electron. Moreover, it will be argued that the experimental measurements of the cross sections for the processes e#gamma# #-># (e tilde)(Z tilde)_1 and ...

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The authors have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative {alpha} subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH{sub 2}-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat {alpha} subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.

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We analyze the potential of the e{sup +}e{sup -} linear colliders, operating in the e{gamma} and {gamma}{gamma} modes, to probe anomalous quartic vector-boson interactions through the multiple production of W's and Z's. We examine all SU(2){sub L}(circle times)U(1){sub Y} chiral operators of order p{sup 4} that lead to new four-gauge-boson interactions but do not alter trilinear vertices. We show that the e{gamma} and {gamma}{gamma} modes are able not only to establish the existence of a strongly interacting symmetry breaking sector but also to probe for anomalous quartic couplings of the order of 10{sup -2} at 90% C.L. Moreover, the information gathered in the e{gamma} mode can be used to reduce the ambiguities of the e{sup +}e{sup -} mode.

Science.gov (United States)

Somatogenic hormones play an important role in regulation of receptors for prolactin (PRL) and estrogen. Plerocercoids of the tapeworm, S. mansonoides produce a factor which mimics some, but not all of the actions reported for GH. Intact female rats were subjected to a constant infusion of plerocercoid growth factor (PGF) via a subcutaneous infection for two weeks to determine if PGF influences receptors for PRL, GH or estradiol. The rate of weight gain in the PGF-treated rats was accelerated in spite of a marked reduction in serum GH. Partially-purified PGF specifically displaced [125I]hGH from rat liver receptors but microsomes prepared from rats treated with PGF specifically bound significantly less [125I]hGH than microsomes from control rats. The reduction in [125I]hGH binding was not due to occupancy or to a change in affinity but to a suppression in receptor concentration. ...

International Nuclear Information System (INIS)

Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an ...

CERN Document Server

An electroweak singlet scalar can couple to pairs of vector bosons through loop-induced dimension five operators. Compared to a Standard Model Higgs boson, the singlet decay widths in the diphotons and Z gamma channels are generically enhanced, while decays into massive final states like WW and ZZ are kinematically disfavored. The overall event rates into gamma gamma and Z gamma can exceed the Standard Model expectations by orders of magnitude. Such a singlet may appear as a resonant signal in the gamma gamma and Z gamma channels, even with a mass above the WW kinematic threshold.

International Nuclear Information System (INIS)

Corrosion testings of model alloys, corresponding by chemical composition to simple and complex-alloyed #gamma#- and #gamma#'-phases of nickel heat-resistant alloys are conducted in sodium sulfate and chloride melts. It is ascertained that heat resistant nickel alloys containing over 50 % of hardening #gamma#'-phase, are subject to disastrous sulfide corrosion (SC). Resistance against SC alloys containing below 50 % of #gamma#'-phase is determined by the resistance of #gamma#-solid solution. 10 refs., 3 figs., 2 tabs.

Science.gov (United States)

Cardiac contractile function is dependent on the integrity and function of the sarcolemmal membrane. Swimming exercise training is known to increase cardiac contractile performance. The purpose of the present study was to examine whether a swimming exercise program would alter sarcolemmal enzyme activity, ion flux, and composition in rat hearts. After approximately 11 wk of exercise training, cardiac myosin and actomyosin Ca2+-adenosinetriphosphatase (ATPase) activity was significantly higher in exercised rat hearts than in sedentary control rat hearts. Glycogen content was increased in plantaris and gastrocnemius muscles from exercised animals as was succinic dehydrogenase activity in gastrocnemius muscle of exercised rats in comparison to sedentary rat preparations. Sarcolemmal vesicles were isolated from hearts of exercise-trained and control rats. ...

International Nuclear Information System (INIS)

We calculate the cross sections for the single production of doubly charged dileptons, both scalar and vector, at e"+e"-, e#gamma#, and #gamma##gamma# colliders at #sq root#s =500 GeV and 1 TeV. The e#gamma# mode is by far the most promising---dileptons whose coupling is as weak as #approx#10"-"4#alpha#_e_m can be observed, for masses virtually up to the kinematic limit. Dileptons of mass up to #sq root#s can also be seen in e"+e"- and #gamma##gamma# colliders, for couplings of order #alpha#_e_m. In all three colliders, most of the cross section comes from events in which the only particles detected are e"-e"- (or #mu#"-#mu#"- or #tau#"-#tau#"-), the decay products of the dilepton, yielding an unmistakable experimental signature.

Energy Technology Data Exchange (ETDEWEB)

We perform an optimal-observable analysis of the final charged-lepton/b-quark momentum distributions in {gamma}{gamma}{yields}t t-bar {yields}lX/bX for various beam polarizations in order to study possible anomalous t t-bar {gamma}, tbW and {gamma}{gamma}H couplings, which could be generated by SU(2) x U(1) gauge-invariant dimension-6 effective operators. We find optimal beam polarizations that will minimize the uncertainty in determination of those non-standard couplings. We also compare e e-bar and {gamma}{gamma} colliders from the viewpoint of the anomalous-top-quark-coupling determination.

Energy Technology Data Exchange (ETDEWEB)

CMSX-4 superalloy laser beam welds were investigated by transmission electron microscopy and atom probe field-ion microscopy (APFIM). The weld microstructure consisted of fine (10- to 50-nm) irregularly shaped {gamma}` precipitates (0.65 to 0.75 volume fraction) within the {gamma} matrix. APFIM compositions of the {gamma} and {gamma}` phases were found to be different from those in the base metal. Concentration profiles across the {gamma} and {gamma}` phases showed extensive variations of Cr, Co and Al concentrations as a function of distance within the {gamma} phase. Calculated lattice misfits near the {gamma}/{gamma}` interface in the welds are positive values compared to the negative values for base metal. (orig.).

Energy Technology Data Exchange (ETDEWEB)

Previous research has shown that SAR hotspots are induced within the laboratory rat and that the resulting thermal hotspots are not entirely dissipated by bloodflow. Two experiments were conducted to determine if hotspot formation in the body and tail of the rat, which is radiation frequency specific, would have behavioral consequences. In the first experiment rats were placed in a plexiglas cage one side of which, when occupied by the rat, commenced microwave radiation exposure; occupancy of the other side terminated exposure. Groups of rats were tested during a baseline period to determine the naturally preferred side of the cage. Subsequent exposure to 360-MHz, 700-MHz or 2450-MHz microwave radiation was made contingent on preferred-side occupancy. A significant reduction in occupancy of the preferred side of the cage, and hence, microwaves subsequently occurred. Reduced exposure ...

Energy Technology Data Exchange (ETDEWEB)

The effect of butylated hydroxytoluene (BHT) pretreatment (0.5% in the diet for 10 days) on the excretion, tissue distribution and DNA binding of orally administered (/sup 14/C)aflatoxin B1 (AFB1) was determined in male Fischer F344 rats. The amount of radioactivity excreted in the urine and feces by 24 hr was higher in BHT-treated rats than in controls. Treatment with BHT enhanced the excretion of water-soluble metabolites in the urine and in the large intestines plus feces at the earlier sampling times. The amount of radioactivity bound to hepatic nuclear DNA was six times less in the BHT-pretreated rats than in controls 6 hr after administration of the isotope. The half-lives of (/sup 14/C)DNA in the rat liver were 30 and 46 hr for control and BHT-pretreated rats, respectively. These results indicate that BHT pretreatment may protect the animal from the carcinogenic effects of ...

International Nuclear Information System (INIS)

The oral administration of 2,3-dihydroxybenzoic acid (DHB) to rats injected intravenously 1 hr previously with "2"3"9Pu citrate caused an increase in urinary excretion of Pu about 8 times that of animals treated with 0.9% NaCl (controls). Liver retention of Pu was decreased from 18% at 2 days in the control animals to 11% in DHB-treated rats. The skeletal retention was similarly reduced from 56% in the control group to 40% in the DHB-treated animals.

International Nuclear Information System (INIS)

Adult and newborn rats were exposed to "2"3"9PuO_2 aerosols of four different size distributions. Rats of both ages were killed at intervals between 1 hr and 60 days postexposure. There were marked age- and particle-related size differences in deposition, although retention was similar throughout. The differences in deposition are attributable to relatively greater deposition of larger particles in the upper respiratory tracts of newborns.

CERN Document Server

Using $\\gamma \\gamma J/\\psi, J/\\psi \\ra e^+ e^-$ and $\\mu^+ \\mu^-$ events from a sample of $14.0\\times 10^6$ $\\psip$ decays collected with the BESII detector, the branching fractions for $\\psip\\ra \\pi^0\\J$, $\\eta\\J$, and $\\psi(2S)\\ar\\gamma\\chi_{c1},\\gamma\\chi_{c2}\\ar\\gamma\\gamma\\jpsi$ are measured to be $B(\\psip\\ra \\pi^0\\J) = (1.43\\pm0.14\\pm0.13)\\times 10^{-3}$, $B(\\psip\\ra \\eta\\J) = (2.98\\pm0.09\\pm0.23)%$, $B(\\psi(2S)\\ar\\gamma\\chi_{c1}\\ar\\gamma\\gamma\\jpsi) = (2.81\\pm0.05\\pm 0.23)%$, and $B(\\psi(2S)\\ar\\gamma\\chi_{c2}\\ar\\gamma\\gamma\\jpsi) = (1.62\\pm0.04\\pm 0.12)%$.

UK PubMed Central (United Kingdom)

The phagocytic and killing abilities of heifer mammary gland macrophages (M phi) and neutrophils were evaluated after exposure to recombinant bovine interferon-gamma (rBoIFN-gamma) stimulation in vitro....Full Text Available

CERN Document Server

The CKM angle $\\gamma/\\phi_{3}$ had been measured by two B-factories, the PEPII collider for the BaBar experiment and the KEKB collider for the Belle experiments. The present paper reports recent progress in $\\gamma/\\phi_{3}$.

UK PubMed Central (United Kingdom)

In Pseudomonas paucimobilis UT26, gamma-hexachlorocyclohexane (gamma-HCH) is converted by two steps of dehydrochlorination to a chemically unstable intermediate, 1,3,4,6-tetrachloro-1,4-cyclohexadiene...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A study was made of the uncoupling action of polychlorinated biphenyls (Kanechlor-400) on oxidative phosphorylation in rat liver mitochondria. Kanechlor-400 (KC-400) at 20 ..mu..g/ml stimulated state 4 respiration of rat liver mitochondria more than 4-fold with ..cap alpha..-ketoglutarate/malate as a substrate, and released the oligomycin-inhibited state 3 respiration. KC-400 also dissipated the membrane potential across the mitochondrial membranes; thus, it acts as an uncoupler of oxidative phosphorylation in rat liver mitochondria. KC-400 altered the permeability properties of mitochondrial membranes as evidenced by the release of endogenous K/sup +/ and the oxidation of exogenously supplied NADH. It is concluded that KC-400 produces a nonspecific increase in mitochondrial ion permeability, thereby dissipating membrane potential, which leads to the uncoupling.

Science.gov (United States)

Increasing the Mg(2+) concentration results in a depression of succincoxidase-linked state 3

Science.gov (United States)

... mast cell staining; ref. 16). The severity of structural radiation injury was assessed using a histopathological radiation injury score ... ...

UK PubMed Central (United Kingdom)

Exposure of female rats to trichloroethylene (TCE), an environmental toxicant commonly found in ground and surface waters throughout the United States, reduces the fertilizability of oocytes...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundBisphenol A (BPA) is widely used in the manufacture of polycarbonate plastics, including infant formula bottles.ObjectivesBased on the...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundChanges in levels of estradiol and progesterone that occur with the transition to reproductive senescence may influence nociception or affect.Full Text Available

UK PubMed Central (United Kingdom)

An acute exudative Escherichia coli pyelonephritis rat model was used to study the influence of progressive pyelonephritis on the efficacy of antibiotic treatment. In this model, transient ureteral...Full Text Available

Science.gov (United States)

... accidentally released from a Soviet military laboratory (Meselson ... Robert Koch and Louis Pasteur worked to introduce ... species (eg, rat, mouse, dog, monkey) for ...

KoreaScience (Korea)

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KoreaScience (Korea)

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British Library Electronic Table of Contents (United Kingdom)

Ethnopharmacological relevance: Tong Luo Jiu Nao (TLJN) is a modern Chinese formula based on Traditional Chinese Medicine theory that has been used to treat ischemic cerebral stroke and vascular dementia. TLJN belongs to the ethnopharmacological family of medicines. In this study, we investigated the mechanism of the TLJN effect on Alzheimer's disease (AD). Aim of the study: To investigate the effect of TLJN on b-amyloid-degrading enzymes and learning and memory in the AD rat brain. Materials and methods: AD rats whose disease was induced by Ab25-35 injection into the bilateral hippocampus CA1 region were subjected to intragastric administration of various preparations. The experimental animals were healthy male Sprague-Dawley rats which were randomly divided into normal, sham, model, TLJN...

Energy Technology Data Exchange (ETDEWEB)

The dose-dependent transfer of [sup 203]Pb to milk and uptake in suckling rats and mice during a three-day nursing period was studied. On day 14 of lactation, the dams were administered a single intravenous dose of lead, labelled with [sup 203]Pb, in four or five doses from 0.0005 to 2.0 mg Pb/kg b.wt. There was a linear relationship between Pb levels in plasma and milk of both species. The Pb milk: plasma ratios at 24 hr after administration were 119 and 89 in mice and rats, respectively. At 72 hr the Pb milk: plasma ratio had decreased to 72 in mice and 35 in rats. The tissue levels of lead in the suckling rats and mice were also linearly correlated with lead concentration in milk at 72 hr, showing that milk could be used as an indicator of lead exposure to the suckling offspring. It is concluded that lead is transported into rat and mouse milk to a very high extent and the ...

International Nuclear Information System (INIS)

Simultaneous exposures of rats and hamsters to inhaled radon daughters, with and without uranium ore dust, were performed daily for five months. Pulmonary pathology developing in 6 to 13 mo after cessation of daily exposures included interstitial fibrosis, emphysema, epithelial hyperplasia, squamous metaplasia, and malignant neoplasia. Rats showed a greater variety and more severe response to these uranium mine inhalation exposures than did hamsters. Inhalation of radon daughters with uranium ore dust displayed the site of greatest damage, including squamous carcinoma, from the nasopharynx to the lungs. Sixty percent of the rats exposed to radon daughters with ore dust developed primary pulmonary carcinomas, providing an appropriate short-term experimental animal model for investigation of respiratory tract carcinogenesis in uranium miners.

UK PubMed Central (United Kingdom)

Astaxanthin (ATX) is a dietary carotenoid of crustaceans and fish that contributes to their coloration. Dietary ATX is important for development and survival of salmonids and crustaceans and has been...Full Text Available

CERN Document Server

The top-color assisted technicolor (TC2) mode predicts the existence of a pair of charged top-pions $\\pi^{\\pm}_t$. In this paper, we study the production of the charged top-pions pair $\\pi^{\\pm}_t$ at next generation $\\gamma\\gamma$ colliders. The results show that the production rates can reach the level of $10^2$ fb with reasonable parameter space. With a large number of events and the clean background, the charged top-pion should be observable at the $\\gamma\\gamma$ colliders. Therefore, our studies can help us to search for charged top-pion, and furthermore, to test the TC2 model.

International Nuclear Information System (INIS)

We present the efficient technique to extract the signal of the intermediate mass Higgs boson from the backgrounds at future #gamma##gamma# colliders. For a clear Higgs detection, it is important to fit the original electron accelerator energy depending on the Higgs mass, to set the polarization of the photon beams and to apply the efficient b quark tagging method. we demonstrate the extraction of information of Higgs parameters and the new physics from the observable physical quantities. It is clearly shown that a future #gamma##gamma# collider will have a rich potential for study on the new physics, as well as the Higgs physics. (author).

CERN Document Server

Heavy quark production in $\\gamma\\gamma$ collisions is analyzed within the approach to hard collisions of photons recently proposed by the author. In this approach evaluating the cross section $\\sigma(\\gamma\\gamma\\to Q\\bar{Q})$ in the ``next-to-leading order of QCD'' requires the inclusion of direct photon contributions up to the order $\\alpha^2\\alpha_s^2$, whereas in the standard approach direct photon terms only up to the order $\\alpha^2\\alpha_s$ are taken into account. Phenomenological consequences of this difference are discussed.

Energy Technology Data Exchange (ETDEWEB)

We investigate the semihard production of neutral pseudoscalar and tensor mesons in high-energy [gamma][gamma] collisions (M=P=[pi][sup 0], [eta], [eta]' or M=T=a[sub 2], f[sub 2], f[sub 2]'). We deal with the exclusive [gamma][gamma][yields]MM' or semi-exclusive [gamma][gamma][yields]MX reactions (X is the hadron jet with not too large mass). The considered transfer momenta are small in comparison with the photon energies and they are large in comparison with the confinement scale. The amplitudes of these processes are determined by the odderon exchange, i.e. three-gluon exchange in the lowest order of perturbative QCD. The cross sections are calculated in this approximation. The possibility of measurements at LEP and at future [gamma][gamma] colliders is discussed. (orig.).

International Nuclear Information System (INIS)

The production of pairs of doubly charged vector bileptons is studied at future #gamma##gamma# colliders. The unpolarized cross section for the #gamma##gamma##->#Y"-"-Y"+"+ subprocess is analytically calculated and convoluted to predict the number of events in the complete e"+e"-#->##gamma##gamma##->#Y"-"-Y"+"+ process. The gauge or nongauge character of the vector bilepton Y"#+-#"#+-# is discussed. It is found that, as a consequence of its spectacular signature, as it decays dominantly into two identical charged leptons, and also due to its charge contents, which significantly enhance the cross section, the detection of this class of particles with mass in the sub-TeV region can be at the reach of these colliders. The model-independent nature of our results is stressed.

CERN Document Server

Il package software GESIS per la gestione di sistemi spettrometrici gamma

International Nuclear Information System (INIS)

The possibility of gamma-absorption identification of the analyzed substance is considered. the basic provisions of the proposed method are concentrated on the example of carbohydrates and hydrocarbons. The above method is tested experimentally on polyethylenes and polystyrene

International Nuclear Information System (INIS)

Sentinel node (SN) scintigraphy for cervical and vulvar cancer guides the gynaecological oncologist in finding the metastatic lymph nodes during lymphadenectomy. The role of the surgical gamma probe in the sentinel node concept in gynaecological oncology is to localise (SN) both intra-operatively and transcutaneously. Intra-operative hand-held collimated gamma probes are increasingly used for detection of the sentinel lymph node. A comparative evaluation of handheld gamma probes: Neoprobe 1500, Europrobe, Gamma Finder, Gamma Ray Prospector GRP1 and GPR2 was performed using different detection methods. Laboratory tests were performed in which sensitivity, spatial resolution and angular sensitivity were evaluated. The results for each gamma probe were summarised and discussed. Awareness of a gamma probes capabilities and limitations should be ...

International Nuclear Information System (INIS)

The coupled neutron-gamma cross section libraries BUGLE-80 and SAILOR are compared, with focus on gamma production and transport and its sensitivity to the thermal component of the neutron flux. In addition, the importance of the prompt versus delayed components of the gamma source is addressed. Although BUGLE-80 shows some discrepancies in the core region, the two libraries demonstrate similar capability in the vicinity of the pressure vessel and beyond. The delayed fission product gammas from the core have little impact on the local gamma fluxes beyond the pressure vessel. Although thermal neutron capture is the dominant component of the gamma source, there is little sensitivity of the gamma source to uncertainties in the thermal neutron cross sections, due to compensating effects which tend to keep the thermal neutron capture rate ...

Energy Technology Data Exchange (ETDEWEB)

Short communication.

International Nuclear Information System (INIS)

State-of-the-art approaches for the calculation of gamma heating in LMFBR core, blanket and reflector regions have been evaluated, with particular emphasis on coupled neutron-gamma methods/cross section sets. The major source of calculational error was found to be the apparent failure to impose a mass-energy balance on total gamma energy yield from neutron capture and other interactions in the preparation of representative neutron-gamma cross section sets. The applicability of many simplifying assumptions was demonstrated, including: volume-weighted homogenization, insensitivity to the shape of the gamma-source-spectrum, gamma energy deposition equal to gamma energy source more than 10 cm inside large zones of uniform composition, and the negligible effect of bremsstrahlung. A simple one-group method was developed to permit rapid, accurate ...

UK PubMed Central (United Kingdom)

1. Novel methods, using L-[ring-2-14C]tryptophan, are described for the measurement of tryptophan 2,3-dioxygenase activity and tryptophan accumulation in isolated rat liver cells. 2. The effects of...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

rho-Iodo-phentermine (IP) and two of its derivatives, N,N,-dimethyl-rho-iodo-phentermine (IDMP) and N-isopropyl-rho-iodo-phentermine (IIP) were synthesized and radiolabelled with iodine by isotopic exchange. They were evaluated as potential brain imaging agents and compared to IAMP. Biodistribution studies in rats did not show that these compounds were superior to IAMP.

UK PubMed Central (United Kingdom)

AbstractIn a previous study using male rats, a correlation was found between the development of “at-level” allodynia in T6-7 dermatomes following severe T8 spinal contusion...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYWe recorded Ca²⁺ current and intracellular Ca²⁺ ([Ca²⁺]_i) in isolated adult rat dorsal root ganglion (DRG) neurons at 20 and...Full Text Available

UK PubMed Central (United Kingdom)

The effects of a moderate-intensity static magnetic field (SMF) on osteoporosis of the lumbar vertebrae were studied in ovariectomized rats. A small disc magnet (maximum magnetic flux density 180 mT)...Full Text Available

UK PubMed Central (United Kingdom)

Within 20 min after intraperitoneal injection of Salmonella enteritidis endotoxin in rats, blood platelet-activating factor (PAF) increased from 4.3 +/- 1.3 to 13.7 +/- 2.0 ng/ml (P less than 0.01)...Full Text Available

International Nuclear Information System (INIS)

Rats that inhaled "2"3"9Pu(NO_3)_4 or "2"3"8Pu(NO_3)_4 developed lung tumors and bone tumors. Lung tumors were clearly associated with Pu inhalation (accumulated dose to lung, 1 rad to 5000 rads); bone tumors could not be unequivocally related to the radiation insult.

Energy Technology Data Exchange (ETDEWEB)

A systematic comparison was undertaken to characterize neurotoxic esterase (NTE) from rat and chicken brain in terms of inhibitor sensitivities, pH optima, and molecular weights. Paraoxon titration of phenyl valerate (PV)-hydrolyzing carboxylesterases showed that rat esterases were more sensitive than chicken to paraoxon inhibition at concentrations less than or equal to microM and superimposable with chicken esterases at concentrations of 2.5-1000 microM. Mipafox titration of the paraoxon-resistant esterases at a fixed paraoxon concentration of 100 microM (mipafox concentration: 0-1000 microM) resulted in a mipafox I50 of 7.3 microM for chicken brain NTE and 11.6 microM for rat brain NTE. NTE (i.e., paraoxon-resistant, mipafox-sensitive esterase activity) comprised 80% of chicken and 60% of rat brain paraoxon-resistant activity with the specific activity of chicken brain NTE approximately twice that of ...

UK PubMed Central (United Kingdom)

Intracellular recordings were made from 1022 somatic lumbar dorsal root ganglion (DRG) neurones in anaesthetized adult rats, classified from dorsal root conduction velocities (CVs) as C, Aδ...Full Text Available

UK PubMed Central (United Kingdom)

Whether the lusitropic potential of short-term exercise in aged rats is linked to an augmentation in the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and an alteration in the...Full Text Available

International Nuclear Information System (INIS)

Pregnant rats were exposed to "8"5Kr for 4-6 hr and sacrificed immediately thereafter. The "8"5Kr concentration in the fetoplacental unit (FPU) was approximately the same at all gestation stages for intact FPU, isolated fetuses or fetal segments, as well as placentas and associated membranes. Maternal tissue concentrations varied over a wide range and only liver and intestine concentrations were relatively similar in both 20-day-gestation (dg) fetuses and adults.

UK PubMed Central (United Kingdom)

1 The decreased binding of drugs and dyes to plasma proteins from male and female rats with acute renal failure has been investigated using equilibrium dialysis at 37 degrees C. 2 Acute renal failure...Full Text Available

UK PubMed Central (United Kingdom)

2,2,5,7,8-pentamethyl-6-chromanol (PMCol) was administered by gavage in rats for 28 days at dose levels of 0, 100, 500, and 2000 mg/kg/day. PMCol administration induced decreases in body weight...Full Text Available

UK PubMed Central (United Kingdom)

In the isolated rat mesenteric bed, the 1 min perfusion with 100 nm anandamide, a concentration that did not evoke vasorelaxation, elicited an acute release of 165.1 ± 9.2 pmol nitric...Full Text Available

UK PubMed Central (United Kingdom)

This report investigates acute changes in the sensitivity of 5-HT_1A receptors in dorsal raphe (dr) neurons in response to elevated serotonin. DR neurons were isolated from adult rats...Full Text Available

UK PubMed Central (United Kingdom)

1,1-Dichloroethylene is reported to produce renal tumors in male mice. It is an hepatotoxin in fasted rats after inhalation. We found that trichloropropane epoxide, an inhibitor of epoxide hydrase,...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

International Nuclear Information System (INIS)

The heavy Higgs bosons H,A of the minimal supersymmetric extension of the Standard Model can be produced as resonances in high-energy #gamma##gamma# colliders. Prospects of the search for these particles in bb-bar and neutralino-pair final states are studied in this report. Heavy Higgs bosons can be found with masses up to about 70-80% of the initial e"+e"- collider energy for moderate values of tan #beta#, i.e. in areas of the parameter space not accessible at other colliders.

Science.gov (United States)

The research sponsored by this grant was conducted in two fields of high-energy astrophysics:

International Nuclear Information System (INIS)

We study heavy physics effects on the Higgs production in #gamma##gamma# fusion using the effective Lagrangian approach. We find that the effects coming from new physics may enhance the standard model predictions for the number of events expected in the final states b-barb, WW, and ZZ up to one order of magnitude, whereas the corresponding number of events for the final state t-bart may be enhanced up to two orders of magnitude.

International Nuclear Information System (INIS)

We investigate the scope of all relevant production modes of charged Higgs bosons in the MSSM, with mass larger than the one of the top quark, at future Linear Colliders operating in #gamma##gamma# mode at the TeV energy scale. Final states with one or two H"#+-# bosons are considered, as produced by both tree- and loop-level interactions. (orig.)

International Nuclear Information System (INIS)

Abstract only.

Energy Technology Data Exchange (ETDEWEB)

This patent describes a {gamma}-ray detector. It comprises: a dislocation-free single crystal having an input surface and a transmission surface at opposite ends thereof; an active shield surrounding the crystal and functioning as an anticoincidence counter; and {gamma}-ray detector means disposed adjacent the transmission surface of the crystal for receiving and detecting {gamma}-rays of a predetermined wavelength incident on the input surface of the crystal at a specific Bragg angle and transmitted through the crystal.

Energy Technology Data Exchange (ETDEWEB)

We have constructed a Monte Carlo generator (the corresponding FORTRAN code can be obtained from the authors upon request) for lowest-order predictions for the processes {gamma}{gamma}{yields}4f and {gamma}{gamma}{yields}4f{gamma} in the standard model and extensions thereof by an effective {gamma}{gamma}H coupling as well as anomalous triple and quartic gauge-boson couplings. Polarization is fully supported, and a realistic photon beam spectrum can be taken into account. For the processes {gamma}{gamma}{yields}4f all helicity amplitudes are explicitly given in a compact form. The presented numerical results contain, in particular, a survey of cross sections for representative final states and their comparison to results obtained with the program package Whizard/Madgraph. The impact of a realistic beam spectrum on cross sections and distributions is illustrated. Moreover, the size ...

KoreaScience (Korea)

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In 1998, research began at Idaho National Engineering and Environmental Laboratory to investigate the application of {sup 6}Li and {sup 7}Li isotopes to the measurement of neutron and gamma radiation. Various size pairs of {sup 6}Li and {sup 7}Li based detectors were exposed to mixed neutron and gamma radiation. Experiments demonstrated that these detectors could be used to measure low level neutron radiation in the presence of high level gamma radiation. (author)

International Nuclear Information System (INIS)

... activation analysis bremsstrahlung environment gamma spectroscopy

International Nuclear Information System (INIS)

The working group reviewed the main difficulties foreseen in doing physics at a gamma-gamma collider. They discussed the requirements for the detector, calculated some of the signal and background rates, compared methods of measuring luminosity, looked at how to get the laser beams in, investigated ways of sweeping aside the electrons and considered ways of disposing of the used beams. No overwhelming obstacles were found but important questions still need to be answered. ((orig.)).

International Nuclear Information System (INIS)

Short communication.

International Nuclear Information System (INIS)

The Albedo Theory was applied in order to develop an one-group algorithm for coupled neutron-gamma shielding calculations. The configuration analyzed consists of multilayered plane systems, where a incident neutron current generates gamma radiation through neutron-gamma reactions. The results obtained by Albedo Method and ANISN code have shown excellent agreement. (author)

Energy Technology Data Exchange (ETDEWEB)

A multi-group neutron-gamma cross-section library in DTF-IV format is supplemented with electron production matrix to generate a coupled neutron-gamma-electron library. This is realized by estimating the contributions from Compton scattering, pair production and photoelectric effect to the electron production cross-sections. A novel application of this new library, which involves transport of neutrons, gammas and electrons, for estimating the Compton current due to a pulse of radiation in air is discussed.

Science.gov (United States)

... PHYSICS ATOMIC AND MOLECULAR PHYSICS AND SPECTROSCOPY NUCLEAR PHYSICS & ELEMENTARY PARTICLE PHYSICS. ...

Science.gov (United States)

The acute effects of injections of the human growth hormone-like factor purified from plerocercoids of the tapeworm Spirometra mansonoides on carbohydrate, lipid, and protein metabolisms were determined in intact rats. Male rats were injected ip with saline, insulin, or various doses of partially purified PGF. The rats injected with insulin had significantly reduced serum glucose concentrations but no dose of PGF caused a change in serum glucose levels. Insulin and PGF stimulated [14C]glucose and [14C]leucine oxidation to 14CO2 in adipose tissue and muscle and increased incorporation of both [14C]glucose carbons into lipids and [14C]leucine into protein in fat and muscle. The responses to PGF were dose-dependent and persisted after 3 hr of incubation in vitro. Injections of naloxone prior to injecting PGF to block the stress response did not prevent the stimulation of insulin-like responses by PGF. Therefore, PGF has ...

Science.gov (United States)

The gene expression of beta(1)-adrenergic receptor (beta(1)AR) and stimulatory G-protein Gsalpha in ventricle after chronic treatment with doxorubicin (DOX) in rat was investigated. The rats were treated with DOX in a dose of 2.5 mg/kg once a week for 5 weeks, the cumulative dose being 12.5 mg/kg. Two weeks after the last injection, the positive inotropic effect of isoproterenol was noticeably decreased in left atrial muscle preparations isolated from DOX-treated rats. Northern blot hybridization showed that the mRNA transcripts of beta(1)AR and Gsalpha, important signal transduction elements for regulating heart rate and contractility, were significantly decreased in the ventricle of DOX-treated rats. Thus, chronic treatment with DOX decreases the gene expression levels of myocardial beta(1)AR and Gsalpha. PMID:15353854

International Nuclear Information System (INIS)

Physical processes in the region of laser conversion for the next Linear Colliders (NLC) are discussed. The main goal of this conversion is to obtain high-energy intense #gamma# beams for #gamma#e and #gamma##gamma# colliders. This conversion has important by-products: (i) one can observe here effect of nonlinear QED (in a strong external field)-production of e"+e"- pairs by a high-energy photon and emission of very high-energy photons by an electron; (ii) one can produce and observe here the invisible axion in colliding #gamma#_0e beams. The NQED effects also result in variation of the spectra of high-energy photons and an additional background. 12 refs., 12 figs., 1 tab.

International Nuclear Information System (INIS)

The short review of complete tree level calculations for three particle final states production at the future e"+e"-, #gamma#e and #gamma##gamma# colliders is presented. The results obtained with the help of CompHEP system for total cross sections and other characteristics of processes in the energy range 0.1-2 TeV are summarized and their comparison with the results of different approaches is discussed. In particular we are interested in the processes of W, Z and H boson production. The reactions under consideration are especially interesting in connection with probing of new couplings, searching for new particle signals and as an important backgrounds to these experiments. The main subjects described are basic reactions rates (sections 2,3), Higgs production in #gamma#e collisions (section 4), the possibilities of testing some four vector bosons interaction vertices and Higgs-fermion coupling (section 5), the process of ...