UK PubMed Central (United Kingdom)

Fibroblast growth factor (FGF) signaling is involved in skeletal development of the vertebrate. Gain-of-function mutations of FGF receptors (FGFR) cause craniosynostosis, premature fusion of the skull,...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

DFNA5 was first identified as a gene causing autosomal dominant hearing loss (HL). Different mutations have been found, all exerting a highly specific gain-of-function effect, in which skipping of exon 8 causes the HL. Later reports revealed the involvement of the gene in different types of cancer. Epigenetic silencing of DFNA5 in a large percentage of gastric, colorectal and breast tumors and p53-dependent transcriptional activity have been reported, concluding that DFNA5 acts as a tumor suppressor gene in different frequent types of cancer. Despite these data, the molecular function of DFNA5 has not been investigated properly. Previous transfection studies with mutant DFNA5 in yeast and in mammalian cells showed a toxic effect of the mutant protein, which was not seen after transfection ...

UK PubMed Central (United Kingdom)

Monogenic autoinflammatory diseases encompass a distinct and growing clinical entity of multisystem inflammatory diseases with known genetic defects in the innate immune system. The diseases...Full Text Available

UK PubMed Central (United Kingdom)

A technique is described for displaying distinct tissue layers of large blood vessel walls as well as measuring their mechanical strain. The technique is based on deuterium double-quantum-filtered (DQF)...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Horizontal beam orbit jitter at frequencies around 10 Hz has been observed in RHIC for several years. The distinct frequencies of this jitter have been found at superconducting low-beta quadrupole triplets around the ring, where they coincide with mechanical modes of the cold masses. Recently, we have identified liquid helium flow as the driving force of these oscillations.

Energy Technology Data Exchange (ETDEWEB)

It is hypothesized that the good performance of Alloy 800 in steam generator service is due to its relative immunity to two distinct mechanisms of stress corrosion cracking; the argument also applies to intergranular corrosion. One mechanism operates in the high-nickel region (Alloy 600 and nearby model alloys) and is due to internal intergranular oxidation. The other operates in the low-nickel (stainless steel) region and is due to de-alloying of Fe and/or Cr. This latter mechanism may, under special conditions, operate in high-Ni, high-Cr alloys such as 690. Some essential features of the de-alloying mechanism are demonstrated using strong caustic solutions, and the prospect of extending this approach to dilute high-temperature environments is discussed. (author)

British Library Electronic Table of Contents (United Kingdom)

Titanate nanotubes were hydrothermally synthesized and their adsorption performances for lead(II) ion removal were studied. The results showed that titanate nanotubes ruptured in the adsorption process resulting in two distinct adsorption stages, thus achieving a maximum adsorption capacity of 3.752mmolg^-^1 of lead(II). Furthermore, it was found that the regeneration of titanate nanotubes loaded with the lead(II) ions can be readily achieved using the saturated EDTA disodium salt aqueous solution, thereby avoiding the trouble of disposal of adsorbent. The adsorption mechanism was also discussed in detail.

CERN Document Server

We study the temporal evolution of coronal loops using data from the Solar X-ray Imager (SXI) on board of GOES-12. This instrument allows us to follow in detail the full lifetime of coronal loops. The observed light curves suggest three somewhat distinct evolutionary phases: rise, main, and decay. The durations and characteristic timescales of these phases are much longer than a cooling time and indicate that the loop-averaged heating rate increases slowly, reaches a maintenance level, and then decreases slowly. This suggests that a single heating mechanism operates for the entire lifetime of the loop. For monolithic loops, the loop-averaged heating rate is the intrinsic energy release rate of the heating mechanism. For loops that are bundles of impulsively heated strands, it is an indication of the frequency of occurrence of individual heating events, or nanoflares. We show that the timescale of the loop-averaged heating ...

Energy Technology Data Exchange (ETDEWEB)

The development of detailed chemical kinetic reaction mechanisms for oxidation of n-octane and iso-octane is described, with emphasis on the factors which are specific to many large hydrocarbon fuel molecules. Elements which are of particular importance are found to include site-specific abstraction of H atoms, radical isomerization of alkyl radicals by internal H atom abstraction, and rapid ..beta..-scission of the alkyl radicals. These features, combined with distinctions in the types of intermediate olefin species produced, are used to explain the significant differences in the rate of oxidation between n-octane and iso-octane. Experimental results from the turbulent flow reactor and low pressure laminar flames, using both n-octane and iso-octane as fuels, are used to test the reaction mechanisms and indicate those parts of the total mechanisms which are in greatest need of further development and ...

Energy Technology Data Exchange (ETDEWEB)

Sucrose phosphate synthase (SPS) catalyzes the transfer of a glycosyl group from an activated donor sugar, such as uridine diphosphate glucose (UDP-Glc), to a saccharide acceptor D-fructose 6-phosphate (F6P), resulting in the formation of UDP and D-sucrose-6'-phosphate (S6P). This is a central regulatory process in the production of sucrose in plants, cyanobacteria, and proteobacteria. Here, we report the crystal structure of SPS from the nonphotosynthetic bacterium Halothermothrix orenii and its complexes with the substrate F6P and the product S6P. SPS has two distinct Rossmann-fold domains with a large substrate binding cleft at the interdomain interface. Structures of two complexes show that both the substrate F6P and the product S6P bind to the A-domain of SPS. Based on comparative analysis of the SPS structure with other related enzymes, the donor substrate, nucleotide diphosphate glucose, binds to the B-domain of SPS. Furthermore, we propose a ...

British Library Electronic Table of Contents (United Kingdom)

Immune function is critical in health and disease. The control and regulation of immune reactions is an area of intense investigation that has important implications for allogeneic hematopoietic cell transplantation. Immune reactions are regulated in a number of important ways. Compartmentalization of immune responses and the production of both pro-inflammatory and anti-inflammatory cytokines play a major role. More recently several populations of T cells that regulate immune responses termed regulatory T cells have been identified. This manuscript will focus on CD4^+CD25^+FoxP3^+ natural regulatory T cells (T"r"e"g) and @a@bTCR^+CD4^+NK1.1^+ natural killer T (NK-T) cells which both suppress graft vs host disease but appear to function by distinct mechanisms.

Energy Technology Data Exchange (ETDEWEB)

Moessbauer spectra of the imitative ancient Jun porcelain indicate that the glaze and body materials contain Fe{sub 2}O{sub 3}, Fe{sub 3}O{sub 4} and structural iron. It is clear that during the firing process, the glaze undergoes dehydration, dehydroxylation, vitrification and recrystallization. The Fe{sup 2+} quadrupole splitting value of the paramagnetic peak of the body material is high even at low firing temperatures. For the body material, the distinction between dehydration and dehydroxylation is not clear. The changes of magnetism of the glaze and body materials in the firing process and the coloring mechanism of the sky-blue Jun porcelain are analyzed in the present paper. (orig.)

International Nuclear Information System (INIS)

AISI 5140 steel was plasma nitrided at various gas mixtures of nitrogen, hydrogen, and argon to investigate the actions of hydrogen and argon on plasma nitriding. The structural and mechanical properties of ion-nitrided AISI 5140 steel have been assessed by evaluating composition of phases, surface hardness, compound layer thickness, and case depth by using X-ray diffraction (XRD), microhardness tests, and scanning electron microscopy (SEM). It was found that the growth of compound layer can be controlled and the diffusion improved when the gas mixture includes H_2 gas. Additionally, it was determined that the amount of Ar in dual gas mixture must be at 20% minimum to obtain distinctive surface hardness and compound layer thickness.

British Library Electronic Table of Contents (United Kingdom)

Action potentials from the brain control the activity of spinal neural networks to produce, by as yet unknown mechanisms, a variety of motor behaviors. Particularly lacking are details on how identified descending neurons integrate diverse sensory inputs to generate specific locomotor patterns. We have examined the operations of the principal neurons in an intriguing midbrain nucleus, the nucleus of the medial longitudinal fasciculus (nMLF), in the larval zebrafish. The nMLF is the most rostral grouping of neurons that projects from the brain well into the spinal cord of teleost fishes, yet there is little direct physiological data available regarding its function. We report here that a distinct set of large, individually-identifiable neurons in nMLF (the MeL and MeM neurons) are activated...

DEFF Research Database (Denmark)

Udgivelsesdato: 2001-Mar

Energy Technology Data Exchange (ETDEWEB)

This project has been concerned with the understanding of certain key physical and physical chemical properties of polymeric systems which are related to their use as working substances in mechanochemical systems. Since the crystal-liquid phase transition is involved in the process of interest, attention has been focused on this transition and on the properties of semi-crystalline polymers. Two kinds of behavior and properties have been studied in this program. One of these is concerned with melting-crystallization under an applied external force. Here the primary matters of concern are the equilibrium melting temperature-stress relations and the associated problem of crystallization kinetics under an applied external stress. The other area of study involves mechanical properties, with particular emphasis on the influence of the morphological and structural variables which describe the semi-crystalline state. We have taken advantage in this work of concurrent ...

UK PubMed Central (United Kingdom)

Over the last century, anatomical studies have shown that the cerebral cortex can be subdivided into structurally distinct regions, giving rise to a new branch of neuroanatomy: ‘architectonics’....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A mathematical model was developed to simulate the combustion process of a direct injection diesel engine. The model considers the key features of such a combustion process; namely fuel droplet evaporation, spray formation, mixing, ignition of heterogeneous burning of the fuel. To model mixing, great emphasis was placed on treating both large and small scale aspects of mixing, the model divides the combustion chamber into three distinct regions of air, fuel spray, and a turbulent plume that is formed once ignition occurs. The fuel spray itself is considered to be composed of multiple zones, which in turn are made of cells of equal mass and of different thermodynamic states. Micromixing of the fuel and air cells, within each zone of the jet and the turbulent plume, is then achieved by utilizing the concept of Monte Carlo stochastic coalescence dispersion technique. The frequency of such cell interactions within each zone is obtained by employing a K-1 turbulent ...

CERN Document Server

Two headed motor proteins, such as kinesin and dynein, hidrolyze environmental ATP in order to propel unidirectionally along cytoskeletal filaments such as microtubules. In the case of kinesin, protein heads bind primarily on the alpha tubulin site of asymmetric alpha-beta 8nm-long tubulin dimers that constitute the microtubular protofilaments. Kinesin dimers overcome local binding forces up to 5pN and are known to move on protofilaments with ATP concentration-dependent speeds while hydrolizing on average one ATP molecule per 8nm step. The salient features of protein trajectories are the distinct abrupt usually 8nm-long steps from one tubulin dimer to the next interlaced with long quiescent binding periods at a tubulin site. Discrete walks of this type are characterized by substantially reduced variances compared to pure biased random walks, and as a result rule out flashing-type ratchet models as possible mechanisms for motor movement. On the ...

Energy Technology Data Exchange (ETDEWEB)

We report here a study of the mechanisms leading to loss of growth control in chicken embryo fibroblasts transformed by Rous sarcoma virus (RSV). We have been particularly concerned with the role of the src gene in this process, and have used RSV mutants temperature sensitive (ts) for transformation to investigate the nature of the growth regulatory lesion. The two principal findings were (1) the stationary phase of the cell cycle (G{sub 1}) in chick embryo fibroblasts seems to have two distinct regulatory compartments (using the terminology of Brooks et al. we refer to these as 'Q' and 'A' states). When rendered stationary at 41.5 C by serum deprivation, normal cells enter a Q state, but cells infected with the ts-mutant occupy an A state. (2) Whereas normal cells can occupy either state depending on culture conditions, the ts-infected cells, at 41.5 C, do not seem to enter Q even though a known src gene ...

Energy Technology Data Exchange (ETDEWEB)

We consider closed string tachyons localized at the fixed points of noncompact nonsupersymmetric orbifolds. We argue that tachyon condensation drives these orbifolds to flat space or supersymmetric ALE spaces. The decay proceeds via an expanding shell of dilaton gradients and curvature which interpolates between two regions of distinct angular geometry. The string coupling remains weak throughout. For small tachyon VEVs, evidence comes from quiver theories on D-branes probes, in which deformations by twisted couplings smoothly connect non-supersymmetric orbifolds to supersymmetric orbifolds of reduced order. For large tachyon VEVs, evidence comes from worldsheet RG flow and spacetime gravity. For C{sup 2}/Z{sub n}, we exhibit infinite sequences of transitions producing SUSY ALE spaces via twisted closed string condensation from non-supersymmetric ALE spaces. In a T-dual description this provides a mechanism for creating NS5-branes via closed ...

CERN Document Server

Modified gravity theories may provide an alternative to dark energy to explain cosmic acceleration. We argue that the observational program developed to test dark energy needs to be augmented to capture new tests of gravity on astrophysical scales. Several distinct signatures of gravity theories exist outside the linear regime, especially owing to the screening mechanism that operates inside halos like the Milky Way to ensure that gravity tests in the solar system are satisfied. This opens up several decades in length scale and new classes of galaxies at low-redshift that can be exploited by surveys. While theoretical work on models of gravity is in the early stages, we can already identify new regimes which cosmological surveys could target to test gravity. These include: 1. A small scale component that focuses on the interior and vicinity of galaxy and cluster halos. 2. Spectroscopy of low redshift galaxies, especially galaxies smaller than ...

Energy Technology Data Exchange (ETDEWEB)

Kerf geometry, kerf wall features, and cutting front characteristics of an Abrasive Waterjet (AWJ) machined Graphite/Epoxy (Gr/Ep) laminate were studied. A macroscopic analyses suggests that geometrical features associated with AWJ machining of Gr/Ep laminates are influenced by three macro regions along the cutting depth. The presence of these regions, including initial damage at jet entry, smooth cutting, and rough cutting near the jet exit, depends on the operating conditions. Design of experiments and analysis of variance were used to determine the effect of cutting parameters on kerf characteristics and to develop empirical models for kerf profile and features of the three distinct macroscopic regions. Cutting front analysis revealed that the mechanisms of material removal in AWJ machining of Gr/Ep do not change over the jet penetration depth. In general, high quality uniform cuts may be obtained by minimizing initial damage at the jet ...

Science.gov (United States)

... The combustible cartridge cases currently used by the USArmy in fielded system- are manufactured by two distinct processes. ...

Science.gov (United States)

Breakdowns occurring in rf accelerating structures will limit the ultimate performance of future linear colliders such as the Compact Linear Collider (CLIC). Because of the similarity of many aspects of dc and rf breakdown, a dc breakdown study is underway at CERN to better understand the vacuum breakdown mechanism in a simple setup. Measurements of the field enhancement factor ? show that the local breakdown field is constant and depends only on the electrode material. With copper electrodes, the local breakdown field is around 10.8GV/m, independent of the gap distance. The ? value characterizes the electrode surface state, and the next macroscopic breakdown field can be well predicted. In breakdown rate experiments, where a constant field is applied to the electrodes, clusters of consecutive breakdowns alternate with quiet periods. The occurrence and lengths of these clusters and quiet periods depend on the evolution of ?. The application of a high field can even ...

Energy Technology Data Exchange (ETDEWEB)

The objective of the current study was the gradual development of the formation of the nitride layer during inductive r.f. plasma nitriding. The study centers on characterization of refined layers and plasma diagnostics in the vicinity of the sample, and raises critical questions of how the layers and interfacial microstructure might affect the near-surface properties. The composition of the plasma near the surface of the sample (plasma layer) was examined by optical emission spectroscopy and mass spectrometry during plasma nitriding and while sputtering the sample after the nitriding process. It was observed that during the nitriding process, the plasma layer contains Ti, NH[sub n] species, N (or/and N[sup +]), H[sub n] species (or/and H[sup +][sub 2]). However, when the nitrided sample was exposed to argon plasma, Ti, Al and NH were observed. It was found that two distinct sublayers, comprising [delta]-TiN and [delta]-TiN + [epsilon]-Ti[sub 2]N phases, were ...

International Nuclear Information System (INIS)

The aim of this study is to prepare some polymeric moulds using Natural rubber latex (NRL)- portland cement composites based on a delayed-action mechanism. Factors affecting the preparation process such as concentration, mixing percentage, additives and their effects on what is regarded as a delayed-action coacervant combination was studied. The effect of Gamma-radiation on the mechanical properties of these moulds was investigated. The effect of natural aging on the prepared moulds was investigated to determine the possibility of using the prepared product in the construction field as expansion joints and cracks filling materials ...etc. The results may be summarized as follows: 1) Composites of natural rubber latex (NRL)-portland cement mould were prepared as two separate parts. The stabilized natural rubber latex (NRL) with hydroxy ethyl cellulose (HEC) as stabilizer and a delayed-action coacervant (sodium meta silicate) present in the ...

Science.gov (United States)

hlgh fiber content composites met the minlmum requirements. (1400 O F ) , the hlgher fiber content as-fabricated composites have impact strengths distinctly ...

UK PubMed Central (United Kingdom)

BackgroundClostridium botulinum produces seven distinct serotypes of botulinum neurotoxins (BoNTs). The genes encoding different subtype neurotoxins of serotypes...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Temperature and concentration profiles of CO in a laminar, axisymmetric, premixed methane-air Bunsen flame are measured using line-of-sight diode laser absorption spectroscopy and computer tomographic (CT) reconstruction. Absorption spectra for P(20) (v=2<-1) and P(27) (v=1<-0) vibrotational transitions of CO were measured at 21 evenly spaced positions over a 1.33 cm span for a 1.3 cm radius flame. CT reconstruction algorithm was based on Fourier convolution. The tomographically reconstructed normalized transmission profiles derived from absorption spectra, in conjunction with a quantum mechanical model for vibrotational behavior of CO, yielded both temperature and concentration profiles. The Bunsen flame had 3 distinct zones: an inner rich-premixed flame zone, an outer non-premixed flame zone and an unburnt core region. The reconstructed temperature profile showed that the core region temperature was close to ambient and rapidly ...

Energy Technology Data Exchange (ETDEWEB)

Eukaryotic genomes encode a zinc finger protein (ZPR1) with tandem ZPR1 domains. In response to growth stimuli, ZPR1 assembles into complexes with eukaryotic translation elongation factor 1A (eEF1A) and the survival motor neurons protein. To gain insight into the structural mechanisms underlying the essential function of ZPR1 in diverse organisms, we determined the crystal structure of a ZPR1 domain tandem and characterized the interaction with eEF1A. The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-stranded {beta} helix with a helical hairpin insertion. ZPR1 binds preferentially to GDP-bound eEF1A but does not directly influence the kinetics of nucleotide exchange or GTP hydrolysis. However, ZPR1 efficiently displaces the exchange factor eEF1B from preformed nucleotide-free complexes, suggesting that it may function as a negative regulator of eEF1A activation. Structure-based mutational and complementation analyses reveal ...

International Nuclear Information System (INIS)

Purpose: The predictive potential of tumor cell kinetic parameters may be improved when they are studied in relation to other microenvironmental parameters. The purpose of this investigation was to quantitatively categorize human tumor samples according to proliferation patterns. Second, it was examined whether these characteristics are retained after xenotransplantation. Methods and Materials: Fifty tumor samples from head-and-neck cancer patients were immunohistochemically stained for Ki-67 and vessels. Also, parts of the samples were transplanted into nude mice. Tumors were categorized according to previously described patterns of proliferation. Vascular and proliferation patterns were analyzed using an image processing system. Results: The 50 tumors were categorized into four patterns of proliferation by visual assessment: marginal (6), intermediate (10), random (21), and mixed (12). One tumor could not be classified. These patterns were quantified by calculating the Ki-67 labeling ...

Science.gov (United States)

A marine propulsion system is a very complicated system composed of many mechanical components. As a result, the vibration signal of a gearbox in the system is strongly coupled with the vibration signatures of other components including a diesel engine and main shaft. It is therefore imperative to assess the coupling effect on diagnostic reliability in the process of gear fault diagnosis. For this reason, a fault detection and diagnosis method based on bispectrum analysis and artificial neural networks (ANNs) was proposed for the gearbox with consideration given to the impact of the other components in marine propulsion systems. To monitor the gear conditions, the bispectrum analysis was first employed to detect gear faults. The amplitude-frequency plots containing gear characteristic signals were then attained based on the bispectrum technique, which could be regarded as an index actualizing forepart gear faults diagnosis. Both the back propagation neural network ...

Energy Technology Data Exchange (ETDEWEB)

The burning characteristics of fuel droplets containing nano and micron-sized aluminum particles were investigated. Particle size, surfactant concentration, and the type of base fluid were varied. In general, nanosuspensions can last much longer than micron suspensions, and ethanol-based fuels were found to achieve much better suspension than n-decane-based fuels. Five distinctive stages (preheating and ignition, classical combustion, microexplosion, surfactant flame, and aluminum droplet flame) were identified for an n-decane/nano-Al droplet, while only the first three stages occurred for an n-decane/micron-Al droplet. For the same solid loading rate and surfactant concentration, the disruption and microexplosion behavior of the micron suspension occurred later with much stronger intensity. The intense droplet fragmentation was accompanied by shell rupture, which caused a massive explosion of particles, and most of them were burned during this event. On the ...

Scientific Electronic Library Online (English)

Abstract in english The aim of the present study was to assess the analgesic activity of the aerial parts of two Hypericum species native to Southern Brazil, H. caprifoliatum and H. polyanthemum. The antinociceptive effect of the H. polyanthemum cyclohexane extract (POL; 180 mg/kg) and of the H. caprifoliatum methanol (MET) and cyclohexane (CH) extracts (90 mg/kg) was evaluated in the hot-plate (ip and po) and writhing (po) tests using male Swiss CF1 mice weighing 22-27 g (N = 10 per group). (more) All extracts displayed antinociceptive effects in the hot-plate test (MET ip = 48%, MET po = 39%, CH ip = 27%, CH po = 50%, POL ip = 74%, and POL po = 49% compared to control). Pretreatment with naloxone (2.5 mg/kg, sc) abolished the effects of CH and POL, and partially prevented the analgesia induced by MET administered by the ip (but not by the po) route. POL and CH (po) significantly reduced the number of writhes induced by acetic acid, while MET was ineffective in this regard. We ...

UK PubMed Central (United Kingdom)

To date few reports have provided direct comparison of psychosocial vulnerability and resources among youth with victimization and perpetration histories. Within a racially diverse, high-risk...Full Text Available

UK PubMed Central (United Kingdom)

SummaryIt has been well established that a single amino acid sequence can give rise to several conformationally distinct amyloid states. The extent to which amyloid structures...Full Text Available

UK PubMed Central (United Kingdom)

Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function. Acetylation of the Tm N-terminal...Full Text Available

UK PubMed Central (United Kingdom)

The composition of carotenoids, along with anthocyanins and chlorophyll, accounts for the distinctive range of colour found in the Actinidia (kiwifruit) species. Lutein and beta-carotene...Full Text Available

UK PubMed Central (United Kingdom)

The aspartate receptor involved in chemotaxis is modified by methyl esterification at four distinct glutamate residues during the adaptive response of this receptor. To explain the high degree of specificity...Full Text Available

UK PubMed Central (United Kingdom)

The evolution of the human mitochondrial genome is characterized by the emergence of ethnically distinct lineages or haplogroups. Nine European, seven Asian (including Native American), and three African...Full Text Available

UK PubMed Central (United Kingdom)

Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms. The aim of present study was to prepare...Full Text Available

UK PubMed Central (United Kingdom)

Several fixed classification experiments test the hypothesis that F₁, f₀, and closure voicing covary between intervocalic stops contrasting...Full Text Available

UK PubMed Central (United Kingdom)

Seventy-nine Mycobacterium bovis isolates recovered from Mexican and Texas cattle were categorized into 16 and 25 distinct types on the basis of IS6110 and direct-repeat fingerprint patterns, respectively....Full Text Available

UK PubMed Central (United Kingdom)

Evidence is presented for a distinctive type of hippocampal synaptic modification [previously described for a molluscan gamma-aminobutyric acid (GABA) synapse after paired pre- and postsynaptic excitation]:...Full Text Available

UK PubMed Central (United Kingdom)

Beginning in 1990, gram-positive rods resembling Actinomyces pyogenes were found with increasing frequency in mixed cultures from various infectious processes, most of them from patients with otitis,...Full Text Available

UK PubMed Central (United Kingdom)

Delta-hemolysin of coagulase-negative staphylococcal strains was immunologically identical to delta-hemolysin of Staphylococcus aureus (Newman) but distinct from delta-hemolysin from a canine strain...Full Text Available

UK PubMed Central (United Kingdom)

Ovine and caprine lentiviruses share the capacity to induce slowly progressive and inflammatory diseases of the central nervous system (leukoencephalitis or visna), lungs (progressive pneumonia or maedi),...Full Text Available

UK PubMed Central (United Kingdom)

Drosophila neuroblasts divide asymmetrically by aligning their mitotic spindle with cortical cell polarity to generate distinct sibling cell types. Neuroblasts asymmetrically localize...Full Text Available

UK PubMed Central (United Kingdom)

We present an algorithm to identify individual neural spikes observed on high-density multi-electrode arrays (MEAs). Our method can distinguish large numbers of distinct neural units, even when spikes...Full Text Available

UK PubMed Central (United Kingdom)

SummaryDnaA initiates chromosomal replication in E. coli at a well regulated time in the cell-cycle. To determine how the spatial distribution of DnaA is related...Full Text Available

UK PubMed Central (United Kingdom)

Many pathogens colonize different anatomical sites, but the selective pressures contributing to survival in the diverse niches are poorly understood. Group A Streptococcus (GAS) is...Full Text Available

UK PubMed Central (United Kingdom)

Human arylamine N-acetyltransferase (NAT) activity is determined by two distinct genes, NAT1 and NAT2, and the classical acetylation polymorphism in NAT2 has been associated with a variety of disorders,...Full Text Available

CERN Document Server

Mechanics and Natural Philosophy Before the Scientific Revolution

Energy Technology Data Exchange (ETDEWEB)

A system is claimed for multiplexing or demultiplexing pulsed laser radiation having an acousto-optical device which is electrically controlled to switch a common path of high pulse rate laser radiation between a plurality of spatially distinct paths for relatively lower pulse rate laser radiation at which the pulses are sequenced according to a predetermined time pattern. The acousto-optical element typically includes a Bragg cell which is electrically driven by a set of distinct frequencies, causing deflection of radiation passing therethrough at a predetermined set of angles whereby pulsed radiation on a single path may be distributed onto the plural separate paths or radiation on plural separate paths of time-sequenced pulses of radiation can be combined into a single path of augmented pulse rate. The control of the acousto-optical element may be provided by selectively switching the output of a plurality of fixed frequency oscillators of ...

Energy Technology Data Exchange (ETDEWEB)

A method and device have been provided for distinguishing Africanized honeybees from European honeybees. The method is based on the discovery of a distinct difference in the acoustical signatures of these two species of honeybees in flight. The European honeybee signature has a fundamental power peak in the 210 to 240 Hz range while the Africanized honeybee signature has a fundamental power peak in the 260 to 290 Hz range. The acoustic signal produced by honeybees is analyzed by means of a detecting device to quickly determine the honeybee species through the detection of the presence of frequencies in one of these distinct ranges. The device includes a microphone for acoustical signal detection which feeds the detected signal into a frequency analyzer which is designed to detect the presence of either of the known fundamental wingbeat frequencies unique to the acoustical signatures of these species as an indication of the identity of the ...

Energy Technology Data Exchange (ETDEWEB)

The further optimisation and improvement of the efficiency of internal combustion engines require the realisation of new technologies leading to a distinctively faster warm-up behaviour of the coolant and lubricants as well as of the engine components after a cold start. In order to achieve reduced fuel consumption and exhaust gas emissions with the help of heat management, the design criteria of innovative cooling systems need to be reflected and adapted to future requirements. The use of intelligent components within the cooling system, such as the 'Stand Alone Rotary Valve' as a thermostat's substitute or the use of coolant pumps with a rotary valve integrated into the pump's inlet chamber, offer new ways to realise in a decisively quicker and more flexible way the appropriate heating up and cooling down procedures at varying driving conditions. A description of both of the intelligent components for the cooling system is ...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Science.gov (United States)

Not Available

KoreaScience (Korea)

Full Text Available

Science.gov (United States)

... wherever possible. The primary interface for mechanical modeling is through PATRAN, a ... PATRAN Neutral File. PATRAN ...

UK PubMed Central (United Kingdom)

In t(15;17) acute promyelocytic leukemia, all-trans retinoic acid (RA) induces leukemic cell maturation in vitro and remission in acute promyelocytic leukemia patients, but in vivo treatments invariably...Full Text Available

UK PubMed Central (United Kingdom)

Polarized epithelial cells develop and maintain distinct apical and basolateral surface domains despite a continuous flux of membranes between these domains. The Na⁺/H⁺exchanger...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

CdTe/SnTe heterojunctions, prepared by EDRI (evaporation-diffusion en regime isotherme) and CSVT (close spaced vapour transport) techniques, have a spectral response in a wide wavelength range (0.3 - 1.5 ..mu..m) which exhibits two distinct bands, corresponding to carrier generation in each material of the couple. Experimental results are interpreted in terms of a Schottky diode model. (orig.).

International Nuclear Information System (INIS)

We describe the early stage of development of an engineering model portable, real-time neutron spectrometer. Several systems of two distinct detector types, a helium 3 gas filled proportional counter and a bulk silicon solid state detector, will be necessary to cover the energy range from thermal to 500 MeV. The advantages and disadvantages of using a moderator were investigated experimentally.

Energy Technology Data Exchange (ETDEWEB)

An analyzer-based X-ray phase-contrast imaging (ABI) setup has been mounted at the Brazilian Synchrotron Light Laboratory (LNLS) for multiple imaging radiography (MIR) purposes. The algorithm employed for treating the MIR data collected at LNLS is described, and its reliability in extracting the distinct types of contrast that can be obtained with MIR is demonstrated by analyzing a test sample (thin polyamide wire). As a practical application, the possibility of studying ophthalmic tissues, corneal sequestra in this case, via MIR is investigated.

International Nuclear Information System (INIS)

Isolated situs inversus of the stomach with otherwise normal position of the thoracic and abdominal viscera is an extremely rare anomaly occurring in two distinct forms. Because of its close relationship to the liver, the right-sided stomach may produce interesting and confusing changes in the liver scan. Two cases illustrate the radiologic features of the two principal types of isolated congenital dextrogastria and the effect of one type on the liver scan.

Energy Technology Data Exchange (ETDEWEB)

An animated test is made for mice with malignant tumors irradiated by a self-made millimetre wave radiator for medical purpose. It is observed that S-180 sarcomas in mice after irradiation has been distinctly suppressed. And remarkable effects are shown through a lot of clinical practices on peptic ulcer, skin-deep ulcer, acute and chromic soft tissue injuries etc.

UK PubMed Central (United Kingdom)

BackgroundThe human endogenous retrovirus HERV-K(HML-2) family is associated with testicular germ cell tumors (GCT). Various HML-2 proviruses encode viral proteins such as Env and...Full Text Available

UK PubMed Central (United Kingdom)

A nonperturbing 13C nuclear magnetic resonance (NMR) method was used to monitor the equilibrium distribution of carboxyl 13C-enriched fatty acids (FA) between distinct binding sites on human serum albumin,...Full Text Available

UK PubMed Central (United Kingdom)

NADPH oxidases are major sources of superoxide (O₂^∸) and hydrogen peroxide (H₂O₂) in vascular cells. Production of these reactive oxygen species...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Duchenne and Becker muscular dystrophies are caused by defects of dystrophin, which forms a part of the membrane cytoskeleton of specialized cells such as muscle. It has been previously shown that the dystrophin-associated protein A1 (59-kDa DAP) is actually a heterogeneous group of phosphorylated proteins consisting of an acidic ({alpha}-A1) and a distinct basic ({beta}-A1) component. Partial peptide sequence of the A1 complex purified from rabbit muscle permitted the design of oligonucleotide probes that were used to isolate a cDNA for one human isoform of A1. This cDNA encodes a basic A1 isoform that is distinct from the recently described syntrophins in Torpedo and mouse and is expressed in many tissues with at least five distinct mRNA species of 5.9, 4.8, 4.3, 3.1, and 1.5 kb. A comparison of the human cDNA sequence with the GenBank expressed sequence tag (EST) data base has identified a relative from human skeletal ...

UK PubMed Central (United Kingdom)

Genetic effects on mechanical properties have been demonstrated in rodents, but not confirmed in primates. Our aim was to quantify the proportion of variation in vertebral trabecular bone mechanical...Full Text Available

CERN Document Server

We use X-ray scattering and molecular simulations to investigate the structural properties of complexes of multivalent cationic lipids and DNA molecules. At low mole fraction of neutral lipids (NLs), $\\Phi_{\\rm NL}$, the complexes show dramatic DNA compaction down to essentially close packed DNA arrays with a DNA interaxial spacing $d_{\\rm DNA}=25\\AA$. A gradual increase in $\\Phi_{\\rm NL}$ does not lead to a continuous increase in $d_{\\rm DNA}$ as observed for DNA complexes of monovalent cationic lipids (CLs). Instead, distinct spacing regimes exist, with sharp transitions between them. Three packing states have been identified: (i) close packed, (ii) condensed, but not close packed, with $d_{\\rm DNA}=27-28\\AA$, and (iii) an expanded state, where $d_{\\rm DNA}$ increases gradually with $\\Phi_{\\rm NL}$. Based on our experimental and computational results, we conclude that the DNA condensation is mediated by the multivalent cationic lipids, which assemble ...

Energy Technology Data Exchange (ETDEWEB)

US Department of Energy (DOE) Order 5400.1 requires the preparation of environmental monitoring plans and implementation of environmental monitoring programs for all DOE facilities. The order identifies two distinct components of environmental monitoring, namely effluent monitoring and environmental surveillance. In general, effluent monitoring has the objectives of characterizing contaminants and demonstrating compliance with applicable standards and permit requirements, whereas environmental surveillance has the broader objective of monitoring the effects of DOE activities on on- and off-site environmental and natural resources. The purpose of this document is to support the Environmental Monitoring Plan for the Oak Ridge Reservation (ORR) by describing the groundwater component of the environmental surveillance program for the DOE facilities on the ORR. The distinctions between groundwater effluent monitoring and groundwater surveillance ...

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Mining lakes are of a world-wide challenging problem caused by the well known acid mine drainage (AMD) and the dynamics of it. In the past, there was no possibility to monitor these mining lakes for an investigation of chemical and biological parameters. But, in general, remote sensing methods are suitable for a monitoring of natural lakes, and now, at the first time, those can be used for a distinction of acid mining lakes in central Germany into different types. In acid mining lakes unusual absorption and scattering properties exist due to the water constituents which are quite different in their optical properties to those of natural lakes. The artificial lakes show high concentrations of metal ions and compounds. This fact was used to discriminate the mining lakes into initial stage, early stage, transitional state and late state. The result is a map of the area where the mining lakes are presented at their current stage. The present method is a proven solution ...

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The principle of radiodiagnosis consists in the fact the X-ray beam is attenuated at different degrees by distinct tissues. For this reason, the anatomical structures have distinct radiological opacities, that produce the radiographic image. The progresses in radiology are related to the development if new radiographic image formation systems that enable an amplification in the quality, with low dose and/or risk to the patient. The objective of this work is the sensitometric valuation of a screen-film combination, that is still the most used, for the standardization, of radiographic images. Thinking about this, were constructed homogeneous phantoms of the chest, skull and pelvis, for the calibration of X-ray beams, with the purpose of obtaining radiographic images of good quality, basing in the routine of a radiodiagnosis service and in the scientific knowledge. Questions were approached about the choice of the suitable equipment, that allow ...

Science.gov (United States)

... 1111/j.1558-5646.2007.00203.x THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF ... to phenotypic plast...

UK PubMed Central (United Kingdom)

BackgroundAlternative splicing is an important mechanism mediating the diversified functions of genes in multicellular organisms, and such event occurs in around 40-60% of human...Full Text Available

CERN Document Server

Drawing Feynman Diagrams with Latex and METAFONT, Part 3: Extension Mechanism and Frequently Asked Questions

International Nuclear Information System (INIS)

White dwarf evolution, particularly in the early phases, is not very strongly constrained by observation. Fortunately, white dwarfs undergo nonradial pulsation in three distinct regions of the H-R diagram. These pulsations provide accurate masses, surface compositional structure and rotation velocities, and help constrain other important physical properties. We demonstrate the application of the tools of stellar seismology to white dwarf evolution using the hot white dwarf star PG 1159-035 and the cool DAV (or ZZ Ceti) stars as examples. From pulsation studies, significant challenges to the theory of white dwarf evolution emerge. 44 refs.

International Nuclear Information System (INIS)

Evaluation of the tolerance limits of X-ray image density accepted by the radiologist shows that for different kinds of examinations, deviations of more than 50% from optimal density lead to images which cannot be used diagnostically. Within this range diagnostic accuracy shows a distinct maximum and diminishes to the limits by 20%. These figures are related to differences in the intensifying factor of screens, sensitivity of films, sensitometric parameters of film processing as well as the doses employed with automatic exposure control devices, measured in clinical conditions. Maximum permissible tolerance limits of the whole imaging system and of its constituents are discussed using the Gaussian law of error addition. (author).

CERN Document Server

Let $n\\in\\mathds{N}$ and $B_n(r,q)$ be the generic Birman-Murakami-Wenzl algebra with respect to indeterminants $r$ and $q$. It is known that $B_n(r,q)$ has two distinct linear representations generated by two central elements of $B_n(r,q)$ called the symmetrizer and antisymmetrizer of $B_n(r,q)$. These generate for $n\\geq 3$ the only one dimensional one sided ideals of $B_n(r,q)$ and generalize the corresponding notion for Hecke algebras of type $A$. In this paper the coefficients of these elements with respect to the graphical basis of $B_n(r,q)$ are determined explicitly.

Energy Technology Data Exchange (ETDEWEB)

We study an analytical solution to the Einstein's equations in 2 + 1-dimensions. The space-time is dynamical and has a line symmetry. The matter content is a minimally coupled, massless, scalar field. Depending on the value of certain parameters, this solution represents three distinct space-times. The first one is at space-time. Then, we have a big bang model with a negative curvature scalar and a real scalar field. The last case is a big bang model with event horizons where the curvature scalar vanishes and the scalar field changes from real to purely imaginary. (author)

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Recent experimental results indicate a dominance of fundamental NN..-->..NN..pi.. processes in near-threshold nuclear pion production. Such two-nucleon processes are revealed in part by distinct polarization effects characterizing both weak (ground state) and strong, highly selective, maximal J coupling transitions for the (p,..pi../sup -/) reaction. For (p,..pi../sup +/), where several NN processes can contribute coherently, analyzing power data suggest a means of distinguishing the contributions from different fundamental NN..-->..NN..pi.. isospin channels.

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Electrostatic torsional micro-mirrors have wide spread use in different industries for diverse purposes. This paper investigates the development of superharmonics and chaotic responses in electrostatic torsional micro-mirrors near the pull-in condition. Appearance of nonlinear phenomena is investigated in models accounting for and disregarding the coupling of torsional and flexural deflections. Analysis of the system response to step and harmonic excitation reveals the appearance of DC and AC symmetry breaking. Increasing the amplitude of harmonic excitation, the response in the form of distinct superharmonics changes to a broad band response, where there is loss of periodicity and the response becomes chaotic. Accounting for flexural deflections in coupled model reduces the voltage thresh...

British Library Electronic Table of Contents (United Kingdom)

Using disaggregated data from the Brazilian stock market, we calculate default probabilities for 30 different economic sectors. Empirical results suggest that domestic macroeconomic factors can explain these default probabilities. In addition, we construct the Minimum Spanning Tree (MST) and the ultrametric hierarchical tree with the MST based on default probabilities to disclose common trends, which reveals that some sectors form clusters. The results of this paper imply that macroeconomic variables have distinct effects on default probabilities, which is important to take into account in credit risk modeling and the generation of stress test scenarios.

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The experimental maturation of an immature kerogen from the Toarcian of the Paris basin has been carried out in a confined system under pressure. The evolution of various thermal maturity parameters was plotted against the corrected organic carbon percentage chosen as a common maturity indicator and compared with data extracted from a natural series. Results show the occurrence of three distinct stages respectively characterized by the removal of oxygenated compounds, the genesis of liquid hydrocarbons and the production of gaseous hydrocarbons.

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Purpose - The purpose of this paper is to elicit the subtle but progressive shift in organizational/institutional interaction with its rivals within a competitive framework, and thereby discusses and analyses paradigm shifts in competition and competitiveness. The paper argues that interorganizational networks and the recent concept of supply chain management may have induced a change in how competitiveness is viewed at the national, industry, and firm levels of interaction. Design/methodology/approach - The paper conceptualizes extant literature into distinct themes of (organizational and institutional) analysis - micro, macro, and meso - and based on this review the paper seeks to identify emerging logics and shifts within mainstream competitiveness literature over the last decade. Findi...

CERN Document Server

The existence of light hidden sectors is an exciting possibility that may be tested in the near future. If DM is allowed to decay into such a hidden sector through GUT suppressed operators, it can accommodate the recent cosmic ray observations without over-producing antiprotons or interfering with the attractive features of the thermal WIMP. Models of this kind are simple to construct, generic and evade all astrophysical bounds. We provide tools for constructing such models and present several distinct examples. The light hidden spectrum and DM couplings can be probed in the near future, by measuring astrophysical photon and neutrino fluxes. These indirect signatures are complimentary to the direct production signals, such as lepton jets, predicted by these models.

International Nuclear Information System (INIS)

XAFS data of metallic glass Al_0_._9_1La_0_._0_9 and a crystalline phase Al_1_1La_3 formed by annealing of the glass were measured at the La L_3 edge at T=12 K and analyzed using the radial distribution function method. The shortest La-Al distance appeared to be distinctively smaller within the glass than in the crystal. This difference decreases the disparity in size of La and Al in the alloy, allowing their mixing in the glassy state. ((orig.)).

International Nuclear Information System (INIS)

Beta-decay studies of the new neutron-rich isotopes sup(58,59)Cr, "6"3Mn, sup(66,67)Co and "6"9Ni, yielding distinctly shorter half-lives than the corresponding theoretical predictions, are presented. The influence of the short half-lives on the r-process calculations of nuclear abundances is discussed. It is concluded that a significantly higher neutron density than the one obtained from explosive helium burning in supernovae is needed to reproduce the observed abundances around A = 80. (orig.).

International Nuclear Information System (INIS)

Rb-Sr phlogopite age determinations, interpreted as emplacement ages, are reported for 15 southern African kimberlites. Jagersfontein and Rietfontein (85 and 95 Ma) have ages typical of the majority of well-known Cretaceous kimberlites, whereas somewhat older ages of about 118 to 125 Ma have been obtained for localities in the Postmasburg, Barkly West and Boshoff districts. Previous zircon ages of 90Ma for Finsch and Roberts Victor are believed to be incorrect. Two other localities in the Barkly West area have significantly younger emplacement ages of about 114 Ma relative to most Barkly West occurrences. Two off-craton kimberlites, Uintjiesberg and Mzongwana, are 100 and 150 Ma in age respectively. Swartruggens and Elandskloof have ages of 150-160 and 165 Ma respectively. A Barkly West occurrence, Klipfontein, also has an apparent age of 160 Ma, but this result cannot be considered reliable. The emplacement ages and initial "8"7Sr/"8"6Sr ratios of southern African Jurassic and ...

KoreaScience (Korea)

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No abstract prepared.

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In this study, a novel compliant mechanism, ''partially compliant spatial slider-crank (RSSP)'' is proposed. All possible configurations of compliant RSSP mechanisms are classified and discussed. A method is derived to determine deflection of the multiple-axis flexural hinge for all positions of the crank. A design procedure for partially compliant RSSP mechanisms is introduced. In order to prove the feasibility of the proposed mathematical model, a real model is built and it is shown that results are consistent.

KoreaScience (Korea)

Full Text Available

International Nuclear Information System (INIS)

Short note.

Science.gov (United States)

Not Available

International Nuclear Information System (INIS)

... Abstract only 1063-7869 v. 44(10) CLASSICAL AND QUANTUM MECHANICS,

DEFF Research Database (Denmark)

Cell biology, clathrin, endocytosis, dynamin, caveolae, cholera toxin

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Not Available

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

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DEFF Research Database (Denmark)

Udgivelsesdato: 2005-Jan-25

KoreaScience (Korea)

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Abstract not provided

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Detailed chemical kinetic reaction mechanisms have been developed to describe the pyrolysis and oxidation of nine n-alkanes larger than n-heptane, including n-octane (n-C{sub 8}H{sub 18}), n-nonane (n-C{sub 9}H{sub 20}), n-decane (n-C{sub 10}H{sub 22}), n-undecane (n-C{sub 11}H{sub 24}), n-dodecane (n-C{sub 12}H{sub 26}), n-tridecane (n-C{sub 13}H{sub 28}), n-tetradecane (n-C{sub 14}H{sub 30}), n-pentadecane (n-C{sub 15}H{sub 32}), and n-hexadecane (n-C{sub 16}H{sub 34}). These mechanisms include both high temperature and low temperature reaction pathways. The mechanisms are based on our previous mechanisms for the primary reference fuels n-heptane and iso-octane, using the reaction class mechanism construction first developed for n-heptane. Individual reaction class rules are as simple as possible in order to focus on the parallelism between all of the n-alkane fuels included in ...

Science.gov (United States)

Russian field surgery with its long history and distinctive characteristics has accumulated great experience in the long-time practice of warfare. Chinese field surgery was established and developed on the basis of studying from the Russian model, which opened up new areas of traffic medicine, molecular traumatology and assessment of biological effects on weapon destruction and carried out in-depth research on wound ballistics, blast injury, burns and combined injury etc. through decades of construction with continuous development and innovation, and a series of major achievements have been made in these fields. By making comparative study on the historical evolution, structure system, characteristics of campaigns and development of society between Chinese and Russian field surgery, it can be found that there are great gaps between them and we should strengthen the research for more rapid development. PMID:20510098

British Library Electronic Table of Contents (United Kingdom)

Paget Schroetter syndrome, or effort thrombosis of the axillosubclavian venous system, is distinct from other forms of upper limb deep vein thrombosis. It occurs in younger patients and often is secondary to competitive sport, music, or strenuous occupation. If untreated, there is a higher incidence of disabling venous hypertension than was previously appreciated. Anticoagulation alone or in combination with thrombolysis leads to a high rate of rethrombosis. We have established a multidisciplinary protocol over 15?years, based on careful patient selection and a combination of lysis, decompressive surgery, and postoperative percutaneous venoplasty. During the past 10?years, a total of 232 decompression procedures have been performed. This article reviews the literature and presents the Exet...

Science.gov (United States)

Biofuels may contribute to both rural economic development and climate change mitigation and adaptation. The Gota Verde Project in Yoro, Honduras, attempts to demonstrate the technical and economic feasibility of small-scale biofuel production for local use by implementing a distinctive approach to feedstock production that encourages small farm sizes, mixed cropping of biofuel feedstock from Jatropha and food crops, particularly corn and beans, grown side by side on the same farmland and the total involvement of small rural farmers. But is the project sustainable? Using EC-Assess, the Earth Charter ethics-based assessment tool, to assess the sustainability of this project, the author found that in some assessment categories the actions surpassed the intended objectives, showing that the project was achieving certain Earth Charter goals without specifically stating its intention to address them. (Contains 3 images, 3 figures and 2 notes.)

International Nuclear Information System (INIS)

Objective: To evaluate the feasibility and clinical application of two stents insertion via single tract for treatment of hepatic hilar cholangiocarcinoma. Methods: Eighteen patients with hepatic hilar cholangiocarcinoma who had left and right bile duct obstruction were treated with stents insertion via right bile duct puncturing routeway. These two stents were implanted between right and left bile duct, and between right bile duct and common bile duct. Results: Eighteen patients obtained successful two stents placement by right bile duct puncturing tract and succeeded with internal drainage for all biliary tree jaundice subsided distinctly. Conclusions: The technique of two stents insertion via single tract could predigest interventional drainage procedure of high bile duct obstruction, reduce operation trauma, shorten handling time and possess promising application value

Energy Technology Data Exchange (ETDEWEB)

The authors have studied in detail the transient enhanced diffusion observed during furnace or rapid-thermal-annealing of ion-implanted Si. The authors show that the effect originates in the trapping of Si atoms by dopant atoms during implantation, which are retained during solid-phase epitaxial (SPE) growth but released by subsequent annealing to cause a transient dopant precipitation or profile broadening. The interstitials condense to form a band of dislocation loops located at the peak of the dopant profile, which may be distinct from the band formed at the original amorphous/crystalline interface. The band can develop into a network and effectively getter the dopant. They discuss the conditions under which the various effects may or may not be observed, and discuss preliminary observations on As/sup +/ implanted Si. 12 references, 12 figures.

International Nuclear Information System (INIS)

The authors have studied in detail the transient enhanced diffusion observed during furnace or rapid-thermal-annealing of ion-implanted Si. The authors show that the effect originates in the trapping of Si atoms by dopant atoms during implantation, which are retained during solid-phase epitaxial (SPE) growth but released by subsequent annealing to cause a transient dopant precipitation or profile broadening. The interstitials condense to form a band of dislocation loops located at the peak of the dopant profile, which may be distinct from the band formed at the original amorphous/crystalline interface. The band can develop into a network and effectively getter the dopant. They discuss the conditions under which the various effects may or may not be observed, and discuss preliminary observations on As"+ implanted Si. 12 references, 12 figures.

British Library Electronic Table of Contents (United Kingdom)

The utilization of thermal fluctuations or Johnson/Nyquist noise as a spectroscopic method to determine transport properties in conductors or semiconductors is developed. The autocorrelation function is obtained from power spectral density measurements thus enabling electronic transport property calculation through the Green-Kubo formalism. This experimental approach is distinct from traditional numerical methods such as molecular dynamics simulations, which have been used to extract the autocorrelation function and directly related physics only. This work reports multi-transport property measurements consisting of the electronic relaxation time, resistivity, mobility, diffusion coefficient, electronic contribution to thermal conductivity and Lorenz number from experimental data. Double va...

British Library Electronic Table of Contents (United Kingdom)

Two studies (N = 420) were conducted to develop and validate the instructional dissent scale (IDS) for use in the college classroom. Participants in study 1 were 210 students who completed the IDS pilot inventory which was subjected to an exploratory factor analysis yielding three distinct factors of dissent (i.e., expressive, rhetorical, vengeful). Concurrent validity support was provided as perceived teacher misbehaviors were associated positively with students' likelihood of engaging in dissent and students reported fewer learning outcomes when they dissented. Participants in study 2 were from a different sample of 210 students who completed the IDS along with measures of classroom justice and student challenge behavior. A confirmatory factor analysis provided support for the hypothesiz...

British Library Electronic Table of Contents (United Kingdom)

Abstract Lyme disease is a perfect model of the complex relationship between host, vector, and the vector-borne bacteria. Both dogs and horses in Romania are exposed to infection. The aim of the present study was to assess the seroreactivity against Borrelia burgdorferi sensu lato in dogs and horses from different regions of Romania. 276 samples from dogs and 260 samples from horses located in different regions of Romania were analyzed by ELISA and IFA, respectively. The effect of several factors potentially affecting seroreactivity (location, age, gender, occupation, and vector exposition risk) was evaluated using Fisher's exact test (R 2.12.0). The overall prevalence of anti-Borrelia antibodies was 6.52% (18/276) in dogs, with a significantly higher positivity (46.15%, 6/13, p=0.0005) re...

CERN Document Server

Partial words are sequences over a finite alphabet that may contain wildcard symbols, called holes, which match or are compatible with all letters; partial words without holes are said to be full words (or simply words). Given an infinite partial word w, the number of distinct full words over the alphabet that are compatible with factors of w of length n, called subwords of w, refers to a measure of complexity of infinite partial words so-called subword complexity. This measure is of particular interest because we can construct partial words with subword complexities not achievable by full words. In this paper, we consider the notion of recurrence over infinite partial words, that is, we study whether all of the finite subwords of a given infinite partial word appear infinitely often, and we establish connections between subword complexity and recurrence in this more general framework.

British Library Electronic Table of Contents (United Kingdom)

Cocoon sericin plays an important role in the reeling of silk and serves as a valuable biomaterial in the field of biomedicine, skincare, and food industries; however, knowledge about cocoon sericin proteins has been limited. For a comprehensive study on sericin, cocoons of eight varieties of silkworm of different geographic origin and with varied cocoon color were analyzed utilizing proteomics and bioinformatics approaches. The electrophoresis pattern demonstrated some common protein bands for all silkworm varieties and distinctive protein bands for some of those examined in the present study. The Ser2 protein, a new Ser3 protein, and four other novel sericin proteins were identified in cocoons for the first time. Products of both Ser1 and Ser3 genes appear to be ubiquitous in the cocoon ...

Energy Technology Data Exchange (ETDEWEB)

Adding capacity to coal-fired plants in small increments of an overall integrated program may be the solution to the 10-year lead time required for the construction of a new plant. A preliminary study evaluates the technical and economic feasibility of a modular natural gas and coal-fired combined-cycle power plant which can be installed in three distinct phases. The plant sizes are suitable for large industrial and utility applications. The Modular Block Power Plant (MBPP) concept offers the advantages of phase construction, lower capital cost, lower cost electricity, lower air emissions, lower water requirements, and reduced solid waste discharge. Other advantages include part load availability, reduced coal inventory requirements, and easier plant siting. 11 figures, 4 tables.

British Library Electronic Table of Contents (United Kingdom)

As a consequence of the close integration of cattle into the food chain of humans, forensically relevant cases involving cattle (Bos taurus) DNA analysis are common. However, scientific publications reporting the information content of the commonly used bovine short tandem repeat (STR) loci remains scarce. Population studies were performed for 16 polymorphic STR loci (BM1818, BM1824, BM2113, CSRM60, CSSM66, ETH3, ETH10, ETH225, HAUT27, ILSTS006, INRA023, SPS115, TGLA53, TGLA122, TGLA126, and TGLA227) including 4,162 randomly selected cattle representing 20 distinct breeds. The power of parental exclusion, expected and observed heterozygosity, probability of identity, and non-amplifying (?null?) allele frequencies were calculated. Major differences existed in the information content between...

CERN Document Server

One of the most important aspects of security organization is to establish a framework to identify security significant points where policies and procedures are declared. The (information) security infrastructure comprises entities, processes, and technology. All are participants in handling information, which is the item that needs to be protected. Privacy and security information technology is a critical and unmet need in the management of personal information. This paper proposes concepts and technologies for management of personal information. Two different types of information can be distinguished: personal information and nonpersonal information. Personal information can be either personal identifiable information (PII), or nonidentifiable information (NII). Security, policy, and technical requirements can be based on this distinction. At the conceptual level, PII is defined and formalized by propositions over infons (discrete pieces of information) that ...

International Nuclear Information System (INIS)

Plutonium, seized from illicit trafficking in nuclear materials, can originate from several, distinct sources. The primary focus of nuclear-forensics investigations of confiscated Pu is to specify correctly its origin. Such specification is possible by means of accurate determination the Pu isotopic composition. Five Pu samples of different origins were analysed by thermal-ionisation mass spectrometry. The source (i.e., the type of production reactor) of each sample was determined by comparing the measured Pu isotopic composition with that calculated by one of two reactor-production computer codes, ORIGEN2 and SCALE. These results, in conjunction with the age determination of each sample, allow us to deduce the origin of each. (author)

Science.gov (United States)

A methodology and hypothetical case study are presented for incorporation of uncertainty and variability into calculations of human health risk appropriate for regional, or basin-scale, groundwater management problems. Uncertainty in well water concentration is introduced through complex contaminant migration patterns in the subsurface. Variability is considered in parameters related to individual behavior patterns and biological effects and to groundwater extraction and distribution networks. A joint uncertainty and variability (JUV) analysis is used to generate a two-dimensional distribution or risk surface that spans both transport uncertainty as well as individual variability. Cuts in this distributional surface (fractiles of variability and percentiles of uncertainty) are presented and discussed. Comparisons with alternative approaches based upon deterministic transport models are also made. In addition, important distinctions are made between the case where ...

Energy Technology Data Exchange (ETDEWEB)

Although state estimation is a mature technique which is widely available in the EMS industry, experience with practical implementation and use of state estimation and network security analysis functions at electric power utilities over the last two decades indicates recurring difficulties and problems attributable to inadequate external network modeling detail and data. This paper addresses the development of a set of guidelines for external network modeling and data exchange, based on the results of a recent project sponsored by EPRI. A general methodology is developed based on the results of a survey of a representative set of utilities and EMS suppliers, supplemented by subsequent analysis and simulation studies. Distinction is made between guidelines pertaining to external network topology, analog measurements, data exchange, and implementation procedures. A philosophy and approach for constructing and testing external models is also presented.

Energy Technology Data Exchange (ETDEWEB)

A novel non-invasive approach to the on-line identification of BWR two-phase flow regimes is investigated. The proposed approach receives neutron radiography images of coolant flow recordings as its input and performs feature extraction on each image via simple and directly computable statistical operators. The extracted features are subsequently used as inputs to an ensemble of self-organizing maps whose outputs demonstrate swift and accurate classification of each image into its corresponding flow regime. The novelty of the approach lies in the use of the self-organizing map which generates the different classes by itself, according to feature similarity of the corresponding images; this contrasts traditional artificial neural networks where the user has to define both the number of distinct classes as well as to supply separate training vectors for each class.

British Library Electronic Table of Contents (United Kingdom)

A multiphase origin of the Cu-Co ores in the western part of the Lufilian fold-and-thrust belt in Central Africa is proposed based on literature, satellite image interpretations and petrographic and fluid inclusion analyses on samples from the stratiform mineralization of Kamoto and Musonoi (DR Congo). The various mineral occurrences in the Katanga Copperbelt can be classified in distinct categories: stratiform, supergene enrichment and vein-type. The stratiform mineralization form the largest group and can be found mainly in Lower Roan (R-2) rocks, which can be identified as ridges on satellite imagery. Ore deposits outside the R-2 occur along lineaments and result often from supergene enrichment.The main phase of the stratiform mineralization in the Katanga Copperbelt occurred during dia...

British Library Electronic Table of Contents (United Kingdom)

Spondylarthritides (SpA) and inflammatory bowel disease (IBD) are idiopathic, chronic inflammatory disorders. Although they are very distinct and well-defined entities, there is clinical and genetic evidence supporting some degree of overlap between the pathogenesis of the two. Subclinical gut inflammation is present in up to two thirds of all SpA patients and can evolve into IBD. This subclinical gut inflammation has been shown to be strongly associated with joint inflammation, providing a clue for a common pathophysiologic background. Despite extensive research progress in the field over the past few years, many questions remain unanswered. In this paper, we focus on the clinical, genetic, and pathophysiologic overlap of SpA and IBD. Furthermore, we discuss some of the targets that may i...

British Library Electronic Table of Contents (United Kingdom)

Complex I (NADH:ubiquinone oxidoreductase) is the largest enzyme of the mitochondrial respiratory chain. Compared to its bacterial counterpart which encompasses 14-17 subunits, mitochondrial complex I has almost tripled its subunit composition during evolution of eukaryotes, by recruitment of so-called accessory subunits, part of them being specific to distinct evolutionary lineages. The increasing availability of numerous broadly sampled eukaryotic genomes now enables the reconstruction of the evolutionary history of this large protein complex. Here, a combination of profile-based sequence comparisons and basic structural properties analyses at the protein level enabled to pinpoint homology relationships between complex I subunits from fungi, mammals or green plants, previously identified...

British Library Electronic Table of Contents (United Kingdom)

This paper opens with a critical analysis of a paradox in contemporary educational research in and about Confucian Heritage Culture (CHC): the assumption that national boundaries coincide with those of a distinct and homogeneous culture, which consistently renders a rather homogenous set of educational phenomena, and collides against a more widely accepted discourse - culture transcends geographical frontiers and is ever evolving in character. It is claimed that this paradox is due to the fact that a thin conception of CHC competes neck-and-neck with a thick conception of it. This paper also addresses the possibility of an ad hoc education research methodology in and about CHC and its compliance issues regarding the mainstream Western research dynamics and philosophy of science. Confucian ...

British Library Electronic Table of Contents (United Kingdom)

Ichnogenera belonging to cleft-foot and wedge-foot bivalves can in most cases be distinguished. This paper addresses the taxonomy of locomotion traces made by wedge-foot bivalves. Ichnogenera Ptychoplasma Fenton and Fenton and Oravaichnium Plicka and Uhrova are reviewed together with related ichnotaxa. Both are interpreted as the locomotion traces of non-cleft, wedge-foot bivalves. Both are usually preserved as hypichnial ridges that include a distinctive bioprint of amygdaloid segments. Ptychoplasma is dominated by amygdaloid segments whereas Oravaichnium is wall-like with only sporadic amygdaloid segments. Ichnospecies of Ptychoplasma are distinguished on the basis of their continuity: P. excelsum Fenton and Fenton (the type) is a relatively continuous trace fossil consisting largely of ...

Energy Technology Data Exchange (ETDEWEB)

During helium beam fuelling experiments in JET, distinctive anisotropic features have been observed in the velocity distribution function describing both fast and thermal alpha particle populations. During the initial fuelling phase the central helium ion temperature observed perpendicular to the magnetic field is higher than the central electron temperature, while the central helium ion temperature observed parallel to the magnetic field is lower than or equal to the central electron temperature. In order to verify temperature measurements of both perpendicular and parallel lines of sight, other independent methods of deducing the ion temperature are investigated: deuterium ion temperature, deuterium density, comparison with neutron rates and profiles (influence of a possible metastable population of helium). 6 refs., 7 figs.

International Nuclear Information System (INIS)

The authors determined migration timing and abundance of juvenile spring chinook salmon Oncorhynchus tshawytscha and juvenile steelhead/rainbow trout O. mykiss from three populations in the Grande Ronde River basin. Based on migration timing and abundance, two distinct life-history strategies of juvenile spring chinook and O.mykiss could be distinguished. An early migrant group left upper rearing areas from July through January with a peak in the fall. A late migrant group descended from upper rearing areas from February through June with a peak in the spring.

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Two grades of WC-10wt.%Co cemented carbide with or without addition of Cr3C2/VC grain growth inhibitor during liquid phase sintering were produced with the goal to investigate their reciprocating sliding friction and wear behaviour against WC-6wt.%Co cemented carbide under unlubricated conditions. The tribological characteristics were obtained on a Plint TE77 tribometer using distinctive normal contact loads. The generated wear tracks were analyzed by scanning electron microscopy and quantified topographically using surface scanning equipment. The post-mortem obtained wear volumes were compared to the online assessed wear. Correlations between wear volume, wear rate and coefficient of friction on the one hand and sliding distance and microstructural properties on the other hand were determ...

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In this work, a highly-sensitive polymeric membrane ion selective electrode for determination of tetracycline was constructed by using molecularly imprinted polymer (MIP) particles as quasi-ionophore. The water-compatible MIP particles targeting tetracycline were synthesized with tetracycline as a template molecule, methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, 2,2?-azobisisobutyronitrile as an initiator and lanthanum ion as a mediator. Benefited from the distinctive performance of the quasi-ionophore and the optimized composition of the membrane and the inner filling solution, the lower detection limit of the electrode was decreased to about 1 ? 10?8 mol/l. It exhibited a good electrode slope 59.8 mV/decade near the theoretical Nernstian one, ...

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Abstract In this brief report, we have described the fine-needle aspiration cytology (FNAC) of a hepatosplenic T-cell lymphoma (HSTCL) in a 60-year-old female patient. The patient complained of fever and heaviness of left upper abdomen. Ultrasound-guided FNAC of the spleen showed immature lymphoid cells, and a diagnosis of primary non-Hodgkin lymphoma of spleen was offered. Subsequently, the patient underwent splenectomy and wedge biopsy of liver that confirmed the cytological diagnosis. The lymphoma cells were positive for CD3 immunostain. Primary hepatosplenic T-cell lymphoma is a rare entity and may often pose diagnostic problems on FNAC. Diagn. Cytopathol. 2010. 2010 Wiley-Liss, Inc.

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Summary The objective of this study was to quantify the genetic diversity among breeds under evaluation for tropical adaptability traits that affect the performance of beef cattle at the USDA/ARS SubTropical Agricultural Research Station (STARS) near Brooksville, FL, USA. Twenty-six microsatellite loci were used to estimate parameters of genetic diversity among the breeds American Brahman, Angus, Senepol and Romosinuano; the latter was comprised of two distinct bloodlines (Costa Rican and Venezuelan). Genotypes of 47 animals from each of these STARS herds were analysed for genetic diversity and genetic distance. Using two methods, the greatest genetic distance was detected between the Costa Rican line of Romosinuano and the Senepol. Gene diversity ranged between 0.64 (Costa Rican line of R...

Science.gov (United States)

Human embryonic stem (ES) cells can undergo spontaneously differentiation in standard culture conditions, demonstrating that the undifferentiated state is relatively unstable. The heterogeneous expression of SSEA3 observed within human ES colonies, provides a means to examine undifferentiated stem cell substates. Through functional testing of single cells we have shown that undifferentiated ES cells can be segregated into functionally discrete subpopulations on the basis of SSEA3 expression: SSEA3(High), SSEA(Low) and SSEA3(Negative). Human ES subpopulations were found to be interconvertible, but they possess distinct properties when challenged to differentiate along the neural lineage. These data suggest that ES cells with pluripotent/self-renewal capacities can exhibit different responses to induction of differentiation. PMID:21763622

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Abstract The benthic marine worm Xenoturbella is frequently contaminated with molluscan DNA, which had earlier caused confusion resulting in a suggested bivalve relationship. In order to find the source of the contaminant, we have used molluscan sequences derived from Xenoturbella and compared them to barcodes obtained from several individuals of the nonmicroscopic molluscs sharing the same environment as Xenoturbella. Using cytochrome oxidase 1, we found the contaminating sequences to be 98% similar to the bivalve Ennucula tenuis. Using the highly variable D1-D2 region of the large ribosomal subunit in Xenoturbella, we found three distinct species of contaminating molluscs, one of which is 99% similar to the bivalve Abra nitida, one of the most abundant bivalves in the Gullmarsfjord where...

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Five arylethylenes with 1-naphthyl, 2-naphthyl, and phenyl groups in 1,2-positions have been studied for singlet-mediated charge-transfer interactions with several amines and paraquat dication. 1-Phenyl-2-(2-naphthyl)ethylene and 1,2-di(2-naphthyl)ethylene exhibit distinct dependence of exciplex emission maxima and lifetimes, and fluorescence quenching constants, on excitation and/or monitoring wavelengths; this is in conformity with the existence of ground-state rotamers for these systems, wtih distinguishable absorption-emission spectra and fluorescence lifetimes. The fluorescence quenching by aromatic amines and paraquat dication occurs with rate constants in the limit of diffusion control and is accompanied by the formation of radical ions in polar solvents (acetonitrile). The transient spectra and kinetics associated with the radical ions, observed by 337.1- and 355-nm laser flash photolysis, are also reported. 10 figures, 4 tables.

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In this paper we demonstrate the electrodeposition of nickel, a common ferromagnetic material, in various magnetically desirable shapes including nanowires, nanoparticles and highly faceted shells. In order to obtain three dimensional mesostructures, the electrochemical deposition of nickel was performed on highly oriented pyrolytic graphite (HOPG) under different electrolyte composition and deposition potential conditions. Under potentiostatic deposition at one distinct potential negative with respect to the reversible potential of nickel, three stages of nucleation and growth take place leading to a complex morphology of deposits. However, dual-pulse potential deposition and electrodeposition in low pH solutions causing hydrogen evolution, lead to nickel deposits in the form of nanowires...

International Nuclear Information System (INIS)

The effects of intradot electron-electron interaction on the photon-assisted Andreev tunneling of a superconductor/carbon-nanotube/superconductor system are studied by using nonequilibrium Green's function technique. The inverse supercurrent reflecting the #pi#-junction transition emerges in the spin-split energy-levels regime polarized by the Coulomb interaction. For the positive tunneling case, the supercurrent reaches its maximum when the spin-degenerate energy-levels are nearest to the Fermi surface. Conversely, for the negative tunneling case, the supercurrent reaches its maximum when two split energy-levels are symmetric with respect of the Fermi surface. The sign and the amplitude of the Andreev tunneling depend distinctly on the energy-level spacing tuned by photon-assisted tunneling. In order to fully understand the transport characteristics, the current-carrying density of states are investigated, which clearly shows the enhancement, suppression or even ...

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The European sea bass Dicentrarchus labrax is a marine teleost important in Mediterranean aquaculture. The development of the entire digestive tract of D. labrax, including the pharynx, was investigated from early embryonic development to day 5 post hatching (dph), when the mouth opens. The digestive tract is initialized at stage 12 somites independently from two distinct infoldings of the endodermal sheet. In the pharyngeal region, the anterior infolding forms the pharynx and the first gill slits at stage 25 somites. The other three gill arches and slits are formed between 1 and 5 dph. Posteriorly, in the gut tube region, a posterior infolding forms the foregut, midgut and hindgut. The anus opens before hatching, at stage 28 somites. Associated organs (liver, pancreas and gall bladder) ar...

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Human pluripotent stem cells hold promising potential in many therapeutics applications including regenerative medicine and drug discovery. Over the past three decades, embryonic stem cell research has illustrated that embryonic stem cells possess two important and distinct properties: the ability to continuously self-renew and the ability to differentiate into all specialized cell types. In this article, we will discuss the continuing evolution of human pluripotent stem cell culture by examining requirements needed for the maintenance of self-renewal in vitro. We will also elaborate on the future direction of the field toward generating a robust and completely defined culture system, which has brought forth collaborations amongst biologists and engineers. As human pluripotent stem cell re...

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Baxter (Australas J Philos 79:449?464, 2001) proposes an ingenious solution to the problem of instantiation based on his theory of cross-count identity. His idea is that where a particular instantiates a universal it shares an aspect with that universal. Both the particular and the universal are numerically identical with the shared aspect in different counts. Although Baxter does not say exactly what a count is, it appears that he takes ways of counting as mysterious primitives against which different numerical identities are defined. In contrast, I defend the idea?suggested, though not quite endorsed, by Baxter himself?that counts are independent dimensions of numerical identity. Different ways of counting are explained by the existence of these different sorts of identity (i.e., counts)...

International Nuclear Information System (INIS)

Dust particles in a plasma are charged negatively and are subject to various types of forces, including a drag force by plasma particles and a force due to the collective nature of a plasma. Dust particles are found in a sheath in laboratories balanced by the gravitational force and the electric force, while dust particles in space are ubiquitous, including planetary magnetospheres and interstellar space. Because of the novel nature of a complex system involving plasma particles and dust particles in a collective way, the dusty plasma is often called a complex plasma. The complex plasma is characterized by two distinctly different scales in time and in space. The plasma with electrons, ions and neutrals is characterized by the collective motion with a fast time scale and a short wavelength, while the dust particles move in a slow time scale and a long spatial scale. Some fundamental aspects of a complex plasma are reviewed and possible applications are discussed. ...

Energy Technology Data Exchange (ETDEWEB)

Data are presented to support the hypothesis that the initial step in the morphologic transformation of irradiated rodent (BALB/3T3) cells is a frequent cellular event involving a large fraction of the irradiated population. This process appears to involve DNA damage, but not to represent a targeted mutation in specific structural gene(s). Morphologic transformation and immortalization appear to be distinct steps in the overall process of transformation. In contradistinction to rodent cells, immortalization is a very rare event in human diploid cells which is induced at extremely low frequencies. The hypothesis is presented that immortality develops among clones of cells bearing stable chromosomal rearrangements which emerge during the proliferation of a population of radiation damaged cells.

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Bothriochloa ischaemum L. and Lespedeza davurica (Laxm.) Schindl. are two co-dominant species of great importance in reducing soil and water loss and maintaining the distinctive natural scenery of the semiarid Loess Plateau of China. Our aim was to determine the growth and interspecific competition between these species under water stress to facilitate the prediction of community succession and guide the selection of appropriate methods of conservation and use in the area. A pot experiment was designed to investigate the effects of water stress and competition on biomass production and allocation, relative competitive ability and water use efficiency of the two species. Bothriochloa ischaemum (a C4 perennial herbaceous grass) was planted in the same pot with L. davurica (a C3 perennial leg...

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How does one assure that both quality and creativity are obtained in basic research environments QA theoreticians have attempted to develop workable definitions of quality, but in more reflective moments, these definitions often fail to capture the deeper essence of the idea of quality.'' This paper asserts that creativity (as a product of the human mind) is a concrete interface between perfunctory definitions of quality (conformance to specifications) and more philosophical speculations about the nature of quality- related ultimates'' like elegance or beauty. In addition, we describe the distinction between creative ideas and creative acts and highlight one of the major inhibitors of creativity, fear. Finally we show that highly creative people often have an irreverent attitude toward boundaries and established authority, and discuss how one can allow for this when designing a QA program in a basic research environment.

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Gamma-aminobutyric acid type A receptor-associated protein (GABARAP) belongs to a family of small ubiquitin-like adaptor proteins implicated in intracellular vesicle trafficking and autophagy. We have used diffusion-ordered nuclear magnetic resonance spectroscopy to study the temperature and concentration dependence of the diffusion properties of GABARAP. Our data suggest the presence of distinct conformational states and provide support for self-association of GABARAP molecules. Assuming a monomer-dimer equilibrium, a temperature-dependent dissociation constant could be derived. Based on a temperature series of {sup 1}H{sup 15}N heteronuclear single quantum coherence nuclear magnetic resonance spectra, we propose residues potentially involved in GABARAP self-interaction. The possible biological significance of these observations is discussed with respect to alternative scenarios of oligomerization.

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The paper describes, for the Hausa farmers of Gidan Jatau in northern Nigeria, the distinct ways in which they see and understand (a) their close and distant environment and (b) their bodies' anatomy and physiology. These ways result in 'another geography' - of both space and being - which, however, may no longer now have the resonance it had in the early 1970s when the author lived in Gidan Jatau for two years as a guest. At that time, the spiritual dimensions of daily life were deemed important to the health and prosperity of each person and to the farmstead as a whole. The argument is made that the urban-centred literature on the bori possession-cult neglects the ordinary, anonymous spirits of house and field. Any serious archaeology of the landscape will need insights into this 'altern...

Science.gov (United States)

We developed an intersection model to integrate parameters estimated from three distinct data sets that resulted from the Exxon Valdez oil spill: (1) the distribution, amount, and movements of spilled oil; (2) the distribution and abundance of sea otters along the Kenai Peninsula; and (3) the estimates of site-specific sea otter mortality relative to oil exposure from otters captured for rehabilitation and from collected carcasses. In this chapter, we describe the data sets and provide examples of how they can be used in the model to generate acute loss estimates. We also examine the assumptions required for the model and provide suggestions for improving and applying the model.

International Nuclear Information System (INIS)

At Cazzaso (Friuli) in northeast Italy, radon ("2"2"2Rn) activity concentration in soil gas in a borehole at a depth of 80 cm has been monitored continuously (at a frequency of once an hour) since May 2004, using a Barasol probe (Algade, France). In addition, environmental parameters (air and soil temperature, barometric pressure) have been recorded. The results have been evaluated and the relationship between radon levels and seismic activity is discussed. Correlation between radon concentration and barometric pressure has been observed. Preliminary results have shown a distinct radon anomaly prior to some earthquakes. (authors)

Science.gov (United States)

Applying an underfeed system, the underfeed circulating spouted bed was designed as a desulfurization reactor. The main objective of the technology is to improve the mixing effect and distribution uniformity of solid particles, and therefore to advance the desulfurization efficiency and calcium utility. In this article, a series of experimental studies were conducted to investigate the fluidization behavior of the solid-gas two-phase flow in the riser. The results show that the technology can distinctly improve the distribution of gas velocity and particle flux on sections compared with the facefeed style. Analysis of pressure fluctuation signals indicates that the operation parameters have significant influence on the flow field in the reaction bed. The existence of injecting flow near the underfeed nozzle has an evident effect on strengthening the particle mixing.

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This paper addresses the influence of CHC on how the insider/outsider distinction is drawn and what consequences follow for the conduct of research. The paper outlines the methodological complexities faced by us whilst conducting our respective research projects in Hong Kong. In the studies reported in this paper we, the researchers, were insiders at one level as both of us have a degree of familiarity with Hong Kong being residents of the city. We were also insiders on a professional level in the contexts under study. However being ethnically non-Chinese positioned us as outsiders. Additionally, our Western-trained research selves accepted certain normative paradigms, whilst our own personal ethno-centricities tended to question these self-same paradigms. In sum, the research context for ...

UK PubMed Central (United Kingdom)

The realization that there existed a G-protein coupled signal transduction mechanism developed gradually and was initially the result of an ill fated quest for uncovering the mechanism of action...Full Text Available

UK PubMed Central (United Kingdom)

AbstractWe combined atomistic molecular-dynamics simulations with quantum-mechanical calculations to investigate the sequence dependence of the stretching behavior of duplex DNA. Our...Full Text Available

UK PubMed Central (United Kingdom)

In all mammals, tissue inflammation leads to pain and behavioral sensitization to thermal and mechanical stimuli called hyperalgesia. We studied pain mechanisms in the African naked mole-rat, an unusual...Full Text Available

International Nuclear Information System (INIS)

Using a new approach to quaternion mechanics based on De Broglie waves, it is shown that such a theory describes tachyons and that the quantum theory of tachyons should be a quaternionic one. (U.K.).

International Nuclear Information System (INIS)

The guide describes a method acceptable to the NRC staff for complying with the Commission's regulations with regard to quality assurance requirements for installation, inspection, and testing of mechanical equipment and systems for water-cooled and high-temperature gas-cooled nuclear power plants.

UK PubMed Central (United Kingdom)

Ion-channels can be activated (gated) by a variety of stimuli including chemicals, voltage, mechanical force or temperature. Whereas molecular mechanisms of ion-channel gating by chemicals and...Full Text Available

UK PubMed Central (United Kingdom)

Most mechanical forces acting on the skeleton are generated either through impact with the ground (i.e., gravitational loading) or through muscle contractions (i.e., muscle loading). If one...Full Text Available

Science.gov (United States)

Investigation of memory effects in air at 0.7 mbar pressure in the presence of vacuum electrical breakdown mechanism has been performed in this paper. The memory effect has been followed using the time delay method.

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In this work, coals of various ranks were dissolved in an acid melange. With the use of IR spectroscopy, it was found that the mechanism of coal dissolution consists in the grafting of polar groups to the peripheral benzene rings of graphite-like systems.

UK PubMed Central (United Kingdom)

DNA interstrand cross-links (ICLs) are critical cytotoxic lesions produced by cancer chemotherapeutic agents such as the nitrogen mustards and platinum drugs; however, the exact mechanism of ICL-induced...Full Text Available

UK PubMed Central (United Kingdom)

Catch is a mechanical state occurring in some invertebrate smooth muscles characterized by high force maintenance and resistance to stretch during extremely slow relaxation. During catch, intracellular...Full Text Available

UK PubMed Central (United Kingdom)

1. The mechanical power spent to accelerate the limbs relative to the trunk in level walking and running, Ẇ_int, has been measured at various `constant' speeds (3-33...Full Text Available

Science.gov (United States)

This dissertation presents the development of the novel mechanical testing technique of in situ nanoindentation in a transmission electron microscope (TEM). This technique makes it possible to simultaneously observe and quantify the mechanical behavior of nano-scale volumes of solids.

UK PubMed Central (United Kingdom)

Methylation of the arginine residues of histones by methyltransferases has important consequences for chromatin structure and gene regulation; however, the molecular mechanism(s) of methyltransferase...Full Text Available

UK PubMed Central (United Kingdom)

The mechanism by which mechanical force regulates the kinetics of a chemical reaction is unknown. Here, we use single-molecule force–clamp spectroscopy and protein engineering to study the effect...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNeuropathic pain (NP) is partially mediated by neuroinflammatory mechanisms, and also modulates local neurogenic inflammation. Dietary lipids, in particular the total amount...Full Text Available

UK PubMed Central (United Kingdom)

Mechanism-based inhibition of cytochrome P450 (CYP) 3A4 is characterized by NADPH-, time-, and concentration-dependent enzyme inactivation, occurring when some drugs are converted by CYPs to reactive...Full Text Available

Science.gov (United States)

Understanding the detailed mechanics of these systems and their place in the general picture of binary star evolution are the dual objectives of this ...

CERN Document Server

we report an ultrafast synchrotron x-ray phase contrast imaging study of the primary breakup mechanism of a coaxial air-assisted water jet. We demonstrate that there exist great similarities in the phenomenology of primary breakup with that of the secondary breakup. Especially, a membrane-mediated breakup mechanism dominates the breakup process for a wide range of air speeds. This finding reveals the intrinsic connections of these two breakup regimes and has deep implications on the unified theoretical approach in treating the breakup mechanism of high speed liquid jet.

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1974. 19 p. United States Anon. American Society of Mechanical Engineers.;

International Nuclear Information System (INIS)

... carbon 14 cholera gels labelling membranes molecules proteins receptors

Energy Technology Data Exchange (ETDEWEB)

High-T/sub c/ superconductivity is due to the action of two mechanisms: (1) plasmon mechanism, i.e., exchange of two-dimensional (2-D) plasmons and (2) strong electron--phonon coupling. The low dimensionality and the small value of the carrier concentration make the plasmon mechanism favorable. The small value of the coherence length leads to a unique opportunity to observe a multigap structure. The proximity effect can be used in order to increase T/sub c/ of A-15 compounds.

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... 31 5.4 FACTORIAL DESIGN STATISTICAL ANALYSIS..... ... resistance. o Factorial design statistical analysis gave the ...

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The crack growth behavior and fracture toughness of two laminated metal composites (6090/SiC/25p laminated with 5182 and ultrahigh-carbon steel laminated with brass) have been studied in both ``crack arrester`` and ``crack divider`` orientations. The mechanisms of crack growth were analyzed and extrinsic toughening mechanisms were found to contribute significantly to the toughness. The influence of laminate architecture (layer thickness and component volume function), component material properties and residual stress on these mechanisms and the resulting crack growth resistance are discussed.

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... hydrostatic pressures up to 700 MPa. The effect of pressure on the ultimate compressive strength is shown. The effect of size on ...

International Science & Technology Center (ISTC)

Research on Diffusion Zinc Cladding of Structural Steels, as Well as Their Mechanical and Corrosion Properties to Replace Their Cyanic Cadmium Plating

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... Descriptors : *Combustible cartridge cases, *Polymers, *Test equipment, *Patents, Combustion chambers, Breech mechanisms, Gas generating ...

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FEP polyethylene mechanical properties affected by UV. " Siloxane-modified materials resist AO. " Nonsilicone polymers attacked by AO ...

Science.gov (United States)

Some aspects of molecular mechanisms common to radiation and chemical carcinogenesis are discussed, particularly the DNA damage done by these agents. Emphasis is placed on epidemiological considerations and on dose-response models used in risk assessment to extrapolate from experimental data obtained at high doses to the effects from long-term, low-level exposures. 3 references, 6 figures. (ACR)

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Papers are presented under the session headings: research in mechanical fragmentation; rock characterization, remote sensing and interface detection; monitoring, data transmission and communications; tunnel boring machines; minewide monitoring and expert systems for ground control; machine guidance; shaft and raise boring; automation of drilling equipment; machine automation and control; new developments in mechanical miners; materials handling; innovative mining systems; general minewide monitoring and expert systems; ground support; human factors; and extraterrestrial mining.

International Nuclear Information System (INIS)

Purpose: To improve the reliability of control rod drive mechanisms for use in BWR type reactors by preventing erroneous insertion of control rods caused by the increase in the coolant pressure. Constitution: A pressure-releaf valve mechanism is provided which opens its valve when a detected difference between the pressure of the coolants flowing through coolant pipeways and the reactor pressure exceeds a predetermined pressure difference. If the coolant pressure increases abnormally, coolants in the coolant pipeway are released to lower the pressure. (Aizawa, K.).

CERN Document Server

We propose a scheme able to generate stationary continuous variable entanglement between an optical and a microwave cavity mode by means of their common interaction with a micro-mechanical resonator. We show that when both cavities are intensely driven one can generate bipartite entanglement between any pair of the tripartite system, and that, due to entanglement sharing, optical-microwave entanglement is efficiently generated at the expense of microwave-mechanical and opto-mechanical entanglement.

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We propose an extension of Gaussian mixture models in the statistical-mechanical point of view. The conventional Gaussian mixture models are formulated to divide all points in given data to some kinds of classes. We introduce some quantum states constructed by superposing conventional classes in linear combinations. Our extension can provide a new algorithm in classifications of data by means of linear response formulas in the statistical mechanics.

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Study of glacial geology, stream drainage, bedrock topography, and subsurface structure maps in Isabella, Midland, Arenac, Gladwin, Clare, Ogemaw, Iosco, Mecosta, and Montcalm counties in Michigan revealed distinct correlations between patterns and types of glacial deposits and subsurface structures. Anticlinal structures associated with the Mt. Pleasant, North Buckeye, and South Buckeye, Hamilton, Deep River, Clayton, Logan, Six Lakes, and West Branch oil and gas fields occur along areas where northeast-trending glacial moraines and truncated, attenuated, or deviated. Furthermore, these anticlinal structures are associated with lacustrine sands and gravels and glacial outwash deposits nearly surrounded by glacial tills or lacustrine sands and clays. All of the anticlinal structures are associated with bedrock topography highs and alignment of streams parallel to the trends of the structures. Comparison of images of subsurface structure and surface elevation data ...

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We summarize the results of point-contact Andreev-reflection (PCAR) spectroscopy in MgB{sub 2} doped by chemical substitutions, either magnetic (Mn) or non-magnetic (Al,C), obtained by us and by other groups in the last four years. Despite the variety of samples used (crystals and polycrystals of various origin) and some minor differences in the experimental techniques, these measurements have directly provided a complete and consistent picture of the effects of chemical substitutions on the gaps of MgB{sub 2} shedding light on other relevant parameters (scattering rates, DOSs) affected by doping. In Al-doped crystals and polycrystals, the gap amplitudes {delta}{sub {sigma}} and {delta}{sub {pi}} - obtained through a two-band Blonder-Tinkham-Klapwijk (BTK) fit of the Andreev-reflection conductance curves - decrease on increasing the Al content x (i.e. on decreasing the critical temperature of the contacts T{sub c}{sup A}), but remain clearly distinct with no ...

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Neutron time-of flight spectra were measured from 90 MeV protons and 140 MeV alpha-particle bombardment of Al, Ni, Zr, and Bi at laboratory angles between 20/sup 0/ and 130/sup 0/. The proton induced neutron spectra reveal three distinct energy regions; a low energy evaporation region, a high-energy region dominated by quasi-free scattering processes and an intermediate-energy region dominated by multi-step, pre-equilibrium processes. In the latter two regions, the spectra show strong angular dependence. The alpha-induced neutron spectra show these same distinct energy regions plus an exponential fall-off above the beam energy per nucleon. The high-energy portions of the forward-angle neutron and proton cross sections are in ratios consistent with the assumption that single nucleon-nucleon scattering dominates. For heavy-mass targets, the low-energy evaporation regions show neutron yields larger than proton yields. The proton-to-neutron ratios ...

International Nuclear Information System (INIS)

We measured neutron time-of-flight spectra from 90 MeV protons and 140 MeV alpha particles bombarding thin targets of Al, Ni, Zr, and Bi at laboratory angles between 20_0 and 135_0. The low-energy (5 to 45 MeV) portions of the spectra were measured with 5 cm diameter by 5 cm deep NE-213 counters at 1 m flight paths with n-#betta# pulse-shape discrimination. The high-energy (35 to 150 MeV) portions of the spectra were measured with 12.7 cm diameter by 10.2 cm deep NE-102 counters at flight paths of 2.0 to 5.0 m. The proton-induced measured neutron spectra reveal three distinct energy regions: a low-energy evaporation region, a high-energy region dominated by the quasifree scattering process, and an intermediate-energy region dominated by multistep, preequilibrium processes. In the latter two regions, the spectra show strong angular dependence. The alpha-particle induced neutron spectra show these same distinct energy regions plus an exponential ...

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Screening of a human placenta lambdagt11 library has led to the isolation of the cDNA for the human ..beta../sub 1/-adrenergic receptor (..beta../sub 1/AR). Used as the probe was the human genomic clone termed G-21. This clone, which contains an intronless gene for a putative receptor, was previously isolated by virtue of its cross hybridization with the human ..beta../sub 2/-adrenergic receptor (..beta../sub 2/AR). The 2.4-kilobase cDNA for the human ..beta../sub 1/AR encodes a protein of 477 amino acid residues that is 69% homologous with the avian ..beta..AR but only 54% homologous with the human ..beta../sub 2/AR. This suggests that the avian gene encoding ..beta..AR and the human gene encoding ..beta../sub 1/AR evolved from a common ancestral gene. RNA blot analysis indicates a message of 2.5 kilobases in rat tissues, with a pattern of tissue distribution consistent with ..beta../sub 1/AR binding. This pattern is quite distinct from the pattern obtained when ...

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In this investigation natural gas has been used as an alternative fuel in diesel engines. Experiments have been performed to study the performance of the dual fuel engine with different diesel quantities as pilot injection. It was suggested in this research that combustion in the dual fuel engine occurred in four stages: the delay period, the slow stage of combustion, the rapid stage of combustion and the fourth stage of combustion. Because of the slower flame speed of natural gas and also because of the prolonged delay period, the combustion of the gas-air continued well into the expansion stroke. These resulted in lower efficiency and higher brake specific fuel consumption, and also higher exhaust gas temperature and higher carbon monoxide in the exhaust when the engine ran on dual fuel. The carbon dioxide and black smoke in the exhaust decreased as the gas was introduced in the engine. The ratio of alternative to diesel fuel was varied at the same load also at different load ...

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This paper presents a stochastic model and estimation procedure for analyzing the failure process of a repairable system. We consider repairable systems whose successive interfailure times reveal a significant dependence while showing an insignificant trend. Neither the renewal process nor the non-homogeneous Poisson process are adequate for modeling such failure processes. Especially when the interfailure times show a cyclic pattern, we may consider a switching of the regimes (states) governing the lifetime distribution of the system. We propose a Markov switching model describing the failure process for such a case. The model postulates that a finite number of states governs the distinct lifetime distributions, and the state makes transitions according to a discrete-time Markov chain. Each of the distinct lifetime distributions represents a failure type that may change after successive repairs. Our model generalizes the mixture model by ...

Science.gov (United States)

This paper discusses the mechanisms of gas breakdown at low values of pressure and inter-electrode gap, i.e. in the vicinity of the Paschen minimum. In this area of pressure and inter-electrode gap values, breakdown occurs either through gas or vacuum mechanisms, and also the so called anomalous Paschen effect appears. Electrical breakdown of electropositive, electronegative and noble gases has been investigated theoretically, experimentally and numerically. Based on the results obtained, regions in which particular breakdown mechanisms appear have been demarcated. Special attention has been devoted to the anomalous Paschen effect as well as to the avalanche vacuum breakdown mechanism.

British Library Electronic Table of Contents (United Kingdom)

Transmission Control Protocol (TCP) provides mechanisms for reliable data communications. Although it works well in wired networks, it fails to offer satisfactory performance in lossy and wireless environments. And in the multi-hop wireless infrastructure, packet delivery suffers high cumulative loss rate if traveling over multiple wireless hops. The Selective acknowledgment (SACK) is one header option that might be used to combat segment corruptions in air channels. In this paper, an alternative set of flow control mechanisms is proposed to handle high packet loss rate in a wireless medium. Using a measurement-based mechanism, sustainable segment delivery is achievable through a novel size-reduction method. Multiple segment retransmission mechanisms are introduced to reduce successive tim...

British Library Electronic Table of Contents (United Kingdom)

A detailed chemical kinetic reaction mechanism is developed for primary reference fuel mixtures of n-hexadecane and 2,2,4,4,6,8,8-heptamethyl nonane for diesel cetane ratings. The mechanisms are constructed using existing rules for reaction pathways and rate expressions developed previously for the primary reference fuels for gasoline octane ratings, n-heptane and iso-octane. These reaction mechanisms are validated by comparisons between computed and experimental results for shock tube ignition and for oxidation under jet-stirred reactor conditions. The combined kinetic reaction mechanism contains the submechanisms for the primary reference fuels for diesel cetane ratings and submechanisms for the primary reference fuels for gasoline octane ratings, all in one integrated large kinetic reac...