falciparum malaria underscore: Topics by WorldWideScience.org

A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

BackgroundPregnant women are more susceptible to severe Plasmodium falciparum malaria, which can lead to poor maternal and fetal outcomes. Few data exist on the...Full Text Available

Phylogenomic analyses of malaria parasites and evolution of their exported proteins

Abs are central to malaria immunity, which is only acquired after years of exposure to Plasmodium falciparum (Pf). Despite the enormous worldwide burden of malaria,...Full Text Available

2010-04-13

Efficacy of drug prophylaxis.

BackgroundPlasmodium falciparum is the most malignant agent of human malaria. It belongs to the taxon Laverania, which includes other ape-infecting Plasmodium...Full Text Available

Contrasting Population Structures of the Genes Encoding Ten Leading Vaccine-Candidate Antigens of the Human Malaria Parasite, Plasmodium falciparum

With the spread of chloroquine resistant Plasmodium falciparum the control of malaria has become increasingly complex. In recent years, particular concern has arisen over how best to prevent malaria...Full Text Available

1989-01-01

The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design....Full Text Available

Molecular Mechanistic Insights into the Endothelial Receptor Mediated Cytoadherence of Plasmodium falciparum-Infected Erythrocytes

Naturally acquired immunity to Plasmodium falciparum malaria in malaria holoendemic areas is characterized by the gradual, age-related development of protection against high-density...Full Text Available

Accumulation of Plasmodium berghei-Infected Red Blood Cells in the Brain Is Crucial for the Development of Cerebral Malaria in Mice?

Cytoadherence or sequestration is essential for the pathogenesis of the most virulent human malaria species, Plasmodium falciparum (P. falciparum). Similar to leukocyte-endothelium...Full Text Available

The relationship between the Plasmodium falciparum parasite ratio in childhood and climate estimates of malaria transmission in Kenya

Cerebral malaria is the most severe complication of human infection with Plasmodium falciparum. It was shown that Plasmodium berghei ANKA-induced cerebral malaria was...Full Text Available

2010-09-01

The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in Tanzania

BackgroundPlasmodium falciparum morbid and fatal risks are considerably higher in areas supporting parasite prevalence ≥25%, when compared with low transmission...Full Text Available

Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens

BackgroundNaturally acquired immune responses against sexual stages of P. falciparum can reduce the transmission of malaria from humans to mosquitoes. These antigens...Full Text Available

Diagnosis of Plasmodium falciparum infection using a solid-phase radioimmunoassay for the detection of malaria antigens

Plasmodium falciparum, the causative agent of human malaria, invades host erythrocytes using several proteins on the surface of the invasive merozoite, which have been proposed...Full Text Available

2010-03-01

Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria

A serodiagnostic test has been developed for the detection of Plasmodium falciparum in infected blood. Using parasite antigens and infected red blood cells from in vitro...Full Text Available

1980-01-01

Blood Group A Antigen Is a Coreceptor in Plasmodium falciparum Rosetting

There is growing epidemiological and molecular evidence that ABO blood group affects host susceptibility to severe Plasmodium falciparum infection. The high frequency of common...Full Text Available

2008-02-15

Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial.

The malaria parasite Plasmodium falciparum utilizes molecules present on the surface of uninfected red blood cells (RBC) for rosette formation, and a dependency on ABO antigens has...Full Text Available

2000-05-01

Antibodies from malaria-exposed pregnant women recognize trypsin resistant epitopes on the surface of Plasmodium falciparum-infected erythrocytes selected for adhesion to chondroitin sulphate A

PMID:20417857

2010-04-24

DEFF Research Database (Denmark)

Udgivelsesdato: 2004-Sep-6

2004-01-01

Evaluation of the OptiMAL Test for Rapid Diagnosis of Plasmodium vivax and Plasmodium falciparum Malaria

Diagnostic comparison of malaria infection in peripheral blood, placental blood and placental biopsies in Cameroonian parturient women

The development of rapid and specific diagnostic tests to identify individuals infected with malaria is of paramount importance in efforts to control the severe public health impact of this disease....Full Text Available

1998-01-01

ABO blood group phenotypes influence parity specific immunity to Plasmodium falciparum malaria in Malawian women

BackgroundIn sub-Saharan Africa, Plasmodium falciparum malaria in pregnancy presents an enormous diagnostic challenge. The epidemiological and clinical relevance...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

BackgroundBlood group O has been significantly associated with increased placental malaria infection in primiparae and reduced risk of infection in multiparae in the Gambia, an area...Full Text Available

Summary Background There is a need for new artemisinin-based combination therapies that are convenient, effective, and safe. We compared the efficacy and safety of pyronaridine-artesunate with that of artemether-lumefantrine for treatment of uncomplicated P falciparum malaria. Methods This phase 3, parallel-group, double-blind, randomised, non-inferiority trial was undertaken in seven sites in Africa and three sites in southeast Asia. In a double-dummy design, patients aged 3-60 years with uncomplicated P falciparum malaria were randomly assigned in a 2:1 ratio to receive pyronaridine-artesunate once a day or artemether-lumefantrine twice a day, orally for 3 days, plus respective placebo. Randomisation was done by computer-generated randomisation sequence in blocks of nine by study centre....

2010-01-01

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Multiplicity of Plasmodium falciparum infection in asymptomatic children in Senegal: relation to transmission, age and erythrocyte variants

Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance

BackgroundIndividuals living in malaria endemic areas generally harbour multiple parasite strains. Multiplicity of infection (MOI) can be an indicator of immune status. However,...Full Text Available

Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial

BackgroundArtemisinin-based combination therapy, currently considered the therapy of choice for uncomplicated Plasmodium falciparum malaria in endemic countries,...Full Text Available

Deletion of the Plasmodium falciparum Merozoite Surface Protein 7 Gene Impairs Parasite Invasion of Erythrocytes?

BackgroundAn artemisinin-based combination therapy, artesunate (AS) plus sulphadoxine-pyrimethamine (SP), was compared to SP monotherapy to provide evidence of further treatment...Full Text Available

Comparative Transcriptional and Genomic Analysis of Plasmodium falciparum Field Isolates

Merozoite surface proteins have been implicated in the initial attachment to the host red blood cell membrane that begins the process of invasion, an important step in the life cycle of the malaria...Full Text Available

2008-12-01

An improved method for undertaking limiting dilution assays for in vitro cloning of Plasmodium falciparum parasites

Mechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted...Full Text Available

2009-10-01

Evaluation of the rapid diagnostic test SDFK40 (Pf-pLDH/pan-pLDH) for the diagnosis of malaria in a non-endemic setting

BackgroundObtaining single parasite clones is required for many techniques in malaria research. Cloning by limiting dilution using microscopy-based assessment for parasite growth...Full Text Available

An open randomized clinical trial in comparing two artesunate-based combination treatments on Plasmodium falciparum malaria in Nigerian children: artesunate/sulphamethoxypyrazine/pyrimethamine (fixed dose over 24 hours) versus artesunate/amodiaquine (fixed dose over 48 hours)

BackgroundThe present study evaluated the SD Bioline Malaria Ag 05FK40 (SDFK40), a three-band RDT detecting Plasmodium falciparum-specific parasite lactate dehydrogenase...Full Text Available

T Cell Responses to the RTS,S/AS01_E and RTS,S/AS02_D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children

BackgroundSeveral studies have demonstrated the efficacy of artemisinin-combination therapy (ACT) across malaria zones of the world. Fixed dose ACT with shorter courses and fewer...Full Text Available

Anti-plasmodial activity and toxicity of extracts of plants used in traditional malaria therapy in Meru and Kilifi Districts of Kenya

BackgroundThe Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

The methanol and aqueous extracts of 10 plant species (Acacia nilotica, Azadirachta indica, Carissa edulis, Fagaropsis angolensis, Harrissonia abyssinica, Myrica salicifolia, Neoboutonia macrocalyx, Strychnos heningsii, Withania somnifera and Zanthoxylum usambarensis) used to treat malaria in Meru and Kilifi Districts, Kenya, were tested for brine shrimp lethality and in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum (NF54 and ENT30). Of the plants tested, 40% of the methanol extracts were toxic to the brine shrimp (LD5050N. macrocalyx had the highest toxicity to brine shrimp nauplii (LD50 21.04+-1.8mg/ml). Methanol extracts of the rest of the plants exhibited mild or no brine shrimp toxicity (LD50>50mg/ml). The aqueo...

2006-01-01

Adult and child malaria mortality in India

Malaria vectors and transmission dynamics in coastal south-western Cameroon

SummaryBackgroundMalaria, a non-fatal disease if detected promptly and treated properly, still causes many deaths in malaria-endemic countries with...Full Text Available

2010-11-20

CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and...

BackgroundMalaria is a major public health problem in Cameroon. Unlike in the southern forested areas where the epidemiology of malaria has been better studied prior to the implementation...Full Text Available

A Rapid Murine Coma and Behavior Scale for Quantitative Assessment of Murine Cerebral Malaria

vaccination card during trial enrollment at the KEMRI/CDC site in Kenya. (Alan Rubin, KEMRI) KEMRI Clinical Officer Paul Ogai reviews a prospective participant's...

2011-09-24

Malaria transmission in two localities in north-western Argentina

BackgroundCerebral malaria (CM) is a neurological syndrome that includes coma and seizures following malaria parasite infection. The pathophysiology is not fully understood and cannot...Full Text Available

var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2

BackgroundMalaria is one of the most important tropical diseases that affects people globally. The influence of environmental conditions in the patterns of temporal distribution...Full Text Available

Sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine in Nigerian children.

BackgroundThe pathogenicity of Plasmodium falciparum is in part due to the ability of the parasitized red blood cell (pRBC) to adhere to intra-vascular host cell...Full Text Available

Signatures of extra dimensions at e{gamma} and {gamma}{gamma} colliders

The in vivo sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine was evaluated in children under 5 years of age in two areas of southern Nigeria in 1987. A modification...Full Text Available

1990-01-01

Sex and Death: The Effects of Innate Immune Factors on the Sexual Reproduction of Malaria Parasites

The authors study the processes {gamma}e {r{underscore}arrow} {gamma}e and {gamma}{gamma} {r{underscore}arrow} {gamma}{gamma}, in the context of the proposal for Weak Scale Quantum Gravity (WSQG) with large extra dimensions. With an ultraviolet cutoff M{sub S} {approximately} 1 TeV for the effective gravity theory, the cross sections obtained for these processes at the Next Linear Collider (NLC), with the e{gamma} an {gamma}{gamma} options, deviate from the predictions of the Standard Model significantly. The results suggest that, for typical proposed NLC energies and luminosities, the predictions of WSQG can be tested in the range 1 TeV {approx{underscore}lt} M{sub S} {approx{underscore}lt} 10 TeV, making e{gamma} an {gamma}{gamma} colliders important tools for probing WSQG.

2000-01-26

Relationship Between Exposure, Clinical Malaria, and Age in an Area of Changing Transmission Intensity

Malaria parasites must undergo a round of sexual reproduction in the blood meal of a mosquito vector to be transmitted between hosts. Developing a transmission-blocking intervention to prevent parasites...Full Text Available

2011-03-01

Prospects, achievements, challenges and opportunities for scaling-up malaria chemoprevention in pregnancy in Tanzania: the perspective of national level officers

The relationship between malaria transmission intensity and clinical disease is important for predicting the outcome of control measures that reduce transmission. Comparisons of hospital data...Full Text Available

2008-08-01

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Performance and usefulness of the Hexagon rapid diagnostic test in children with asymptomatic malaria living in the Mount Cameroon region

ObjectivesTo describe the prospects, achievements, challenges and opportunities for implementing intermittent preventive treatment for malaria in pregnancy (IPTp) in Tanzania in...Full Text Available

An Immune Basis for Malaria Protection by the Sickle Cell Trait

BackgroundRapid and correct diagnosis of malaria is considered an important strategy in the control of the disease. However, it remains to be determined how well these tests can...Full Text Available

A Research Agenda for Malaria Eradication: Drugs

BackgroundMalaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism...Full Text Available

2005-05-01

Genetic Applications in Avian Conservation

Antimalarial drugs will be essential tools at all stages of malaria elimination along the path towards eradication, including the early control or “attack” phase to drive down transmission...Full Text Available

2011-01-01

Intermittent preventive treatment of malaria during pregnancy: a qualitative study of knowledge, attitudes and practices of district health managers, antenatal care staff and pregnant women in Korogwe District, North-Eastern Tanzania

... structure along an elevational gradient in Hawaiian honeycreepers reveals contrasting evolutionary responses to avian malaria. BMC Evolutionary Biology 8: ... ...

The Challenge of Basic Education for All.

BackgroundIntermittent preventive treatment of malaria during pregnancy (IPTp) is a key intervention in the national strategy for malaria control in Tanzania. SP, the current drug...Full Text Available

Evidence of an inflammatory-like response in non-normally pigmented tissues of two scleractinian corals

Clarifies the concept of universal basic education. Highlights the need for performance criteria and ways to measure literacy attainment. Identifies issues related to improving primary education, seeing adult literacy as its necessary complement. Underscores the substantial resources required to achieve universal basic education. (CH)

1988-12-01

Electrochemical properties for the lithium ion conductive (100-x)(0.6Li{sub 2}S{center{underscore}dot}0.4SiS{sub 2}){center{underscore}dot}xLi{sub 4}SiO{sub 4} oxysulfide glasses

Increasing evidence of links between climate change, anthropogenic stress and coral disease underscores the importance of understanding the mechanisms by which reef-building corals resist infection...Full Text Available

2008-12-07

Ribose metabolism and nucleic acid synthesis in normal and glucose-6-phosphate dehydrogenase-deficient human erythrocytes infected with Plasmodium falciparum.

Thermal, electrical, and electrochemical properties were investigated for the (100-x)(0.6Li{sub 2}S{center{underscore}dot}0.4SiS{sub 2}){center{underscore}dot}xLi{sub 4}SiO{sub 4} oxysulfide glasses. The glass with x = 5 exhibited high electrical conductivity of about 10{sup {minus}3} S cm{sup {minus}1} at room temperature, high glass stability against crystallization, and good chemical stability in contact with Li metal. Cyclic voltammetry also suggested that this glass has a wide electrochemical window of more than 10 V. On the other hand, further addition of Li{sub 4}SiO{sub 4} up to 20 mol% lowered the conductivity, glass stability against crystallization, and electrochemical stability for the oxysulfide glasses.

1999-09-01

Decreased semen quality in a male infected with malaria.

The metabolism of pentose-phosphate was investigated in Plasmodium falciparum-infected normal and glucose-6-phosphate dehydrogenase (G6PD)-deficient human red blood cells in vitro. 5'-Phosphoribosyl-1-pyrophosphate...Full Text Available

1986-04-01

Contributions of Anopheles larval control to malaria suppression in tropical Africa: review of achievements and potential

A 33-year-old male of proven fertility suffered six attacks of malaria while resident in an African country. For this he received anti-malarial drugs. Semen analysis performed after the fourth attack, and repeated during the following 2 years after his return to Israel, revealed severe oligozoospermia, necrozoospermia and occasionally even azoospermia. Immunological examination of the patient revealed an inverse ratio of T-cell subsets and mast cell degranulation in response to palludrin. Twenty-five months after the last attack of malaria a significant improvement was found in semen quality and there was an increase in the ratio of T-helper to T-suppressor cytotoxic cells. These observations indicate that although malaria and its treatment may affect spermatogenesis, recovery may be expected eventually. PMID:3500921

1987-10-01

British Library Electronic Table of Contents (United Kingdom)

Abstract. Malaria vector control targeting the larval stages of mosquitoes was applied successfully against many species of Anopheles (Diptera: Culicidae) in malarious countries until the mid-20th Century. Since the introduction of DDT in the 1940s and the associated development of indoor residual spraying (IRS), which usually has a more powerful impact than larval control on vectorial capacity, the focus of malaria prevention programmes has shifted to the control of adult vectors. In the Afrotropical Region, where malaria is transmitted mainly by Anopheles funestus Giles and members of the Anopheles gambiae Giles complex, gaps in information on larval ecology and the ability of An. gambiae sensu lato to exploit a wide variety of larval habitats have discouraged efforts to develop and impl...

2007-01-01

Chemical and anti malaria study In vivo and In vitro of extracts of among barks of Maytenus rigid (Celastraceae)

Building the Perfect Parasite: Cell Division in Apicomplexa

Portuguese 2004 [1 p.] Brazil Estevam, Charles dos S. Andrade Neto,

Statistical properties of nucleotide clusters in DNA sequences*

Apicomplexans are pathogens responsible for malaria, toxoplasmosis, and crytposporidiosis in humans, and a wide range of livestock diseases. These unicellular eukaryotes are stealthy invaders, sheltering...Full Text Available

2007-06-01

Impact of Plasmodium falciparum infection on the frequency of moderate to severe anaemia in children below 10 years of age in Gabon

Using the complete genome of Plasmodium falciparum 3D7 which has 14 chromosomes as an example, we have examined the distribution functions for the amount of C or G and A or T consecutively...Full Text Available

2005-05-01

Socio-economic differences and health seeking behaviour for the diagnosis and treatment of malaria: a case study of four local government areas operating the Bamako initiative programme in south-east Nigeria

BackgroundImproving the understanding of childhood malarial anaemia may help in the design of appropriate management strategies.MethodsA...Full Text Available

A Randomized Trial Assessing the Safety and Immunogenicity of AS01 and AS02 Adjuvanted RTS,S Malaria Vaccine Candidates in Children in Gabon

BackgroundMalaria is one of the leading causes of mortality and morbidity in Nigeria. It is not known how user fees introduced under the Bamako Initiative (BI) system affect healthcare...Full Text Available

Using schoolchildren's reports of bed net use monitored by schoolteachers as a proxy of community coverage in malaria endemic areas of Uganda:

BackgroundThe malaria vaccine candidate antigen RTS,S includes parts of the pre-erythrocytic stage circumsporozoite protein fused to the Hepatitis B surface antigen. Two Adjuvant...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Summary Objective Community-based information on the delivery and use of health interventions is important to monitor the effectiveness of the Roll Back Malaria programme. However, community surveys to determine coverage for insecticide-treated bed nets are time-consuming and costly. We wanted to assess whether schoolchildren's reports of household ownership of a bed net and coverage among high-risk groups monitored by schoolteachers through a questionnaire could be used as a proxy of household ownership of bed net and coverage at community level, for routine monitoring of malaria control programmes. Method 3602 schoolchildren in 39 randomly selected schools and 2798 heads of households in 39 villages were interviewed about their use of either insecticide-treated or untreated bed nets. Res...

2007-01-01

Studies on the breeding habitats of the vector mosquito Anopheles baimai and its relationship to malaria incidence in Northeastern region of India

British Library Electronic Table of Contents (United Kingdom)

Entomological survey was conducted to know the breeding habitat preference of the forest breeder malaria vector Anopheles baimaii, known earlier as An. dirus species D in the northeastern region of India. Breeding potential of the vector in forest areas was found to be high in water stored in jungle pool (69.84%) followed by elephant footprints with clear water (39.13%) and with turbid water (26.19%), whereas in forest fringe areas, the vector breeding was more prominent in elephant footprints: 65.11% in clear water and 62.5% in turbid water. Although other habitats had shown only low breeding of the vector, all types of habitats were positively correlated with malaria occurrence. Cattle hoof marks (r?=?0.998) and elephant footprint (turbid; r?=?0.999) explained nearly the same amount of v...

2010-01-01

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Satellite imagery in the study and forecast of malaria

Reduction of anti-malarial consumption after rapid diagnostic tests implementation in Dar es Salaam: a before-after and cluster randomized controlled study

More than 30 years ago, human beings looked back from the Moon to see the magnificent spectacle of Earth-rise. The technology that put us into space has since been used to assess the damage...Full Text Available

2002-02-07

Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin

BackgroundPresumptive treatment of all febrile patients with anti-malarials leads to massive over-treatment. The aim was to assess the effect of implementing malaria rapid diagnostic...Full Text Available

Processing and microfiltration of mosquitoes for malaria antigen detection in a rapid dot immunobinding assay.

The pyrethroid knockdown resistance gene (kdr) has become widespread in Anopheles gambiae in West Africa. A trial to test the continuing efficacy of insecticide-treated...Full Text Available

2007-02-01

Prevalence of contraindications to mefloquine use among USA military personnel deployed to Afghanistan

Data on a technique for the detection of antigen from arthropod vectors in a dot immunobinding assay are presented. In this system, antigen present in the vector was first solubilized in sodium dodecyl...Full Text Available

1990-08-01

Measuring Urbanization Pattern and Extent for Malaria Research: A Review of Remote Sensing Approaches

BackgroundMefloquine has historically been considered safe and well-tolerated for long-term malaria chemoprophylaxis, but its prescribing requires careful attention to rule out contraindications...Full Text Available

Malaria knowledge and agricultural practices that promote mosquito breeding in two rural farming communities in Oyo State, Nigeria

Within the next 30 years, the proportion of urban dwellers will rise from under half to two thirds of the world’s population. Such a shift will entail massive public health consequences,...Full Text Available

2004-09-01

Larvicidal effects of a neem (Azadirachta indica) oil formulation on the malaria vector Anopheles gambiae

BackgroundAgricultural practices such as the use of irrigation during rice cultivation, the use of ponds for fish farming and the storage of water in tanks for livestock provide...Full Text Available

Landscape determinants and remote sensing of anopheline mosquito larval habitats in the western Kenya highlands

BackgroundLarviciding is a key strategy used in many vector control programmes around the world. Costs could be reduced if larvicides could be manufactured locally. The potential...Full Text Available

Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial

BackgroundIn the past two decades the east African highlands have experienced several major malaria epidemics. Currently there is a renewed interest in exploring the possibility...Full Text Available

Field application of a colorimetric method of assaying chloroquine and desethylchloroquine in urine

BackgroundHelminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections...Full Text Available

Effect of discriminative plant-sugar feeding on the survival and fecundity of Anopheles gambiae

In a study in western Kenya of malaria-infected adult women who had been treated with chloroquine, we compared the level of chloroquine and its principal metabolite, desethylchloroquine, in urine,...Full Text Available

1988-01-01

ABO blood group and the risk of placental malaria in sub-Saharan Africa

BackgroundA previous study showed for Anopheles gambiae s.s. a gradation of feeding preference on common plant species growing in a malaria holoendemic area in western...Full Text Available

Adult abundance, biting behavior and parity of Anopheles aquasalis, Curry 1932 in two malarious areas of Sucre State, Venezuela

BackgroundIn malarious areas of the world, a higher proportion of the population has blood group O than in non-malarious areas. This is probably due to a survival advantage conferred...Full Text Available

Scientific Electronic Library Online (English)

Abstract in english The principal vector of malaria in eastern Venezuela, Anopheles aquasalis, is exophagic and exophilic. Control using indoor insecticide house sprays has failed to lower the number of malaria cases. Therefore, studies were initiated in two villages of the eastern coastal state of Sucre to better understand this vector's biology and develop a more integrated control program. An. aquasalis was found to have a crepuscular biting behavior with a major peak at dusk and a minor (more) peak at dawn. Mosquitos were collected more outdoors than indoors. Forty-seven percent of the biting took place before people went to bed (22:30 hr) and 69% of the mosquitos biting during this time period bite outdoors. Outdoor biting could be the reason why indoor spraying alone did not lower malaria cases. Seasonal abundance was greater in the rainy season compared to the dry season. Seasonal parous rates were high (78.3%-100%) ...

1993-09-01

Targeted doctors, missing patients: Obstetric health services and sectarian conflict in Northern Pakistan

British Library Electronic Table of Contents (United Kingdom)

The spectre of exclusionary medical service provision, restricted clinic access and physician targeting in sectarian-divided Iraq underscores the crucial and timely need for qualitative research into the inter-relationship between conflict, identity and health. In response, this paper provides a critical ethnography of obstetric service provision and patient access during Shia-Sunni hostilities in Gilgit Town, capital of Pakistans Northern Areas (2005). I analyse how services were embedded in and constrained by sectarian affiliation in ways that detrimentally impacted Sunni women patients and hospital staff, resulting in profoundly diminished clinic access, reduced physician coverage and a higher observed incidence of maternal morbidity and mortality. The paper first situates obstetric med...

2010-01-01

Performance of high-temperature central receiver systems

Large robotized turning centers described

The development of central receiver technology for the production of electricity is reasonably well established. One possible direction for future research and development efforts funded by the Department of Energy is high-temperature, high-performance systems. In this paper, the performance of central receiver systems is investigated for a range of heliostat sizes, field configurations, plant sizes, and receiver temperatures. The maximum plant efficiency achievable in a central receiver system that uses simple cavity geometry is shown for a range of receiver temperatures. The impact of changes in heliostat size, field packing density, and canting and focusing strategies on system efficiency are investigated over a range of plant sizes. The results of the study underscore the importance of accommodating high absorber plane fluxes in order to efficiently produce working temperatures at or above 1200/sup 0/C.

1984-07-01

Cluster approach to quantum-chemical calculations of chemisorption and heterogeneous catalytic systems

The introduction of numerical control (NC) machine tools has made it possible to automate machining in series and small series production. The organization of automated production sections merged NC machine tools with automated transport systems. However, both the one and the other require the presence of an operative at the machine for low skilled operations. Industrial robots perform a number of auxiliary operations, such as equipment loading-unloading and control, changing cutting and auxiliary tools, controlling workpieces and parts, and cleaning of location surfaces. When used with a group of equipment they perform transfer operations between the machine tools. Industrial robots eliminate the need for workers to form auxiliary operations. This underscores the importance of developing robotized manufacturing centers providing for minimal human participation in production and creating conditions for two and three shift operation of equipment. Work carried out at ...

1985-09-01

Malaria and other vector-borne infection surveillance in the U.S. Department of Defense Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance program: review of 2009 accomplishments

The increasing use of quantum-chemical methods in catalysis has underscored the importance of developing and improving semiempirical approximations oriented toward calculations of the total energy and geometry, offering a means for examining intermolecular interactions. In this article a general approach is proposed, using weighting factors for certain regions of distances, i.e., introducing different parametrization into the various regions. A scheme designated MINDO/3-HB is presented as an extension of the MINDO/3 scheme to the region of hydrogen bonds and ..pi..-complexes of olefins with Broensted acid centers (BACs). Examples of cluster calculations are given for the adsorption of ammonia, pyridine, ethylene, and ethanol on the BACs of zeolites. In the example of the process of zeolite synthesis, the possibilities of the cluster approach are discussed for calculations related to the formation of catalysts.

1987-07-01

Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae.

Vector-borne infections (VBI) are defined as infectious diseases transmitted by the bite or mechanical transfer of arthropod vectors. They constitute a significant proportion of the global infectious...Full Text Available

Control of pyrethroid and DDT-resistant Anopheles gambiae by application of indoor residual spraying or mosquito nets treated with a long-lasting organophosphate insecticide, chlorpyrifos-methyl

The sequence and cytological location of five Anopheles gambiae glutathione S-transferase (GST) genes are described. Three of these genes, aggst1-8, aggst1-9 and aggst1-10, belong to the insect class...Full Text Available

2001-10-15

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A qualitative study of the feasibility and community perception on the effectiveness of artemether-lumefantrine use in the context of home management of malaria in south-west Nigeria

BackgroundScaling up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) with support from the Global Fund and President's Malaria Initiative is providing...Full Text Available

CASSCF and CASPT2 ab initio electronic structure calculations find singlet methylnitrene is an energy minimum

BackgroundIn Nigeria ACT use at the community level has not been evaluated and the use of antimalarial drugs (commonly chloroquine (CQ)) at home has been shown to be largely incorrect....Full Text Available

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

(12/11)CASSCF and (12/11)CASPT2 ab initio electronic structure calculations with both the cc-pVDZ and cc-pVTZ basis sets find that there is a barrier to the very exothermic hydrogen shift that converts singlet methylnitrene, CH{sub 3}N, to methyleneimine, H{sub 2}C{double{underscore}bond}NH. These two energy minima are connected by a transition structure of C{sub s} symmetry, which is computed to lie 3.8 kcal/mol above the reactant at the (12/11)CASPT2/cc-pVTZ//(12/11)CASSCF/cc-pVTZ level of theory. The (12/11)CASSCF/cc-pVTZ value for the lowest frequency vibration in the transition structure is 854 cm{sup {minus}1}, and CASPT2 calculations concur that this a{double{underscore}prime} vibration does indeed have a positive force constant. Thus, there is no evidence that this geometry is actually a mountain top, rather than a transition structure, on the global potential energy surface or that a C{sub 1} pathway of lower energy connects the ...

2000-02-16

British Library Electronic Table of Contents (United Kingdom)

Ethnobotanical and chemotaxonomical studies for antiparasitic activity of Colombian Annonaceae were carried out. In vitro antiprotozoal activity of 36 extracts obtained from six different species was determined against promastigotes of three Leishmania species, epimastigotes of Trypanosoma cruzi and both chloroquine sensitive (F32) and resistant (W2) Plasmodium falciparum. Cytotoxic activity was evaluated in U-937 cells. Active extracts were selected according their selectivity index (SI). Extracts from Annona muricata, Rollinia exsucca, Rollinia pittieri and Xylopia aromatica were active against Leishmania spp. and Trypanosoma cruzi showing IC50 values lower than 25mg/ml. Hexane extract from Rollinia pittieri leaves was the most selective against Trypanosoma cruzi and Leishmania spp. (IS=...

2007-01-01

Neuroinflammation and brain infections: Historical context and current perspectives

British Library Electronic Table of Contents (United Kingdom)

An overview of current concepts on neuroinflammation and on the dialogue between neurons and non-neuronal cells in three important infections of the central nervous systems (rabies, cerebral malaria, and human African trypanosomiasis or sleeping sickness) is here presented. Large numbers of cases affected by these diseases are currently reported. In the context of an issue dedicated to Camillo Golgi, historical notes on seminal discoveries on these diseases are also presented. Neuroinflammation is currently closely associated with pathogenetic mechanisms of chronic neurodegenerative diseases. Neuroinflammatory signaling in brain infections is instead relatively neglected in the neuroscience community, despite the fact that the above infections provide paradigmatic examples of alterations o...

2011-01-01

Automation in a material processing/storage facility

beta-Lactamases among extended-spectrum beta-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in The Netherlands

The Savannah River Site (SRS) is currently developing a new facility, the Actinide Packaging and Storage Facility (APSF), to process and store legacy materials from the United States nuclear stockpile. A variety of materials, with a variety of properties, packaging and handling/storage requirements, will be processed and stored at the facility. Since these materials are hazardous and radioactive, automation will be used to minimize worker exposure. Other benefits derived from automation of the facility include increased throughput capacity and enhanced security. The diversity of materials and packaging geometries to be handled poses challenges to the automation of facility processes. In addition, the nature of the materials to be processed underscores the need for safety, reliability and serviceability. The application of automation in this facility must, therefore, be accomplished in a rational and disciplined manner to satisfy the strict operational requirements ...

1997-05-01

DEFF Research Database (Denmark)

Objectives: The purpose of this work was to study the genetic determinants responsible for extended-spectrum beta-lactamase (ESBL) resistance of Salmonella isolated from Dutch poultry, poultry meat and hospitalized humans. Methods: Thirty-four ESBL-resistant Salmonella isolates from The Netherlands were tested towards 21 antimicrobial agents. PCR and sequencing were used to determine the underlying genetic determinants responsible for the ESBL phenotypes. The transferability of the ESBL phenotypes was tested by conjugation to a susceptible Salmonella enterica serovar Dublin and plasmid purification, restriction fragment length polymorphism (RFLP) and pulsed-field gel electrophoresis (PFGE) were employed to further characterize a subset of the isolates. Results: A great genetic diversity was seen among the isolates. The bla(TEM-52) gene was most predominant and was found among Salmonella enterica serovars Blockley, Thomson, London, Enteritidis phage type 14b, Paratyphi B, Virchow and ...

2005-01-01

Status of the advanced boiling water reactor and simplified boiling water reactor

Renal artery stenosis after radiotherapy for Ewing's sarcoma

This paper reports that the excess of U.S. electrical generating capacity which has existed for the past 15 years is coming to an end as we enter the 1990s. Environmental and energy security issues associated with fossil fuels are kindling renewed interest in the nuclear option. The importance of these issues are underscored by the National Energy Strategy (NES) which calls for actions which are designed to ensure that the nuclear power option is available to utilities. Utilities, utility associations, and nuclear suppliers, under the leadership of the Nuclear Power Oversight Committee (NPOC), have jointly developed a 14 point strategic plan aimed at establishing a predictable regulatory environment, standardized and pre-licensed Advanced Light Water Reactor (ALWR) nuclear plants, resolving the long-term waste management issue, and other enabling conditions. GE is participating in this national effort and GE's family of advanced nuclear power plants feature two new ...

1992-04-13

Powering future vehicles with the refuelable zinc/air battery

Background: the fact that therapeutic irradiation can induce significant stenosis in the arteries of the head, neck, and chest, as welt as in the aorta and the iliac arteries, is familiar in daily practice and well documented in the literature. By contrast, radiation-induced renal artery stenosis seems to be a less widely known complication. Patients and methods: the sudden onset of medically refractory arterial hypertension and coma in a 27-year-old man is reported, who had been treated at age 20 with chemotherapy and radiotherapy for Ewing's sarcoma in the lumbar region. This treatment had been performed at the hospital of Sion, Switzerland in 2001. Also, the relevant literature from 1965 to 2007 is reviewed to underscore various aspects of this problem and to demonstrate the clinical relevance of renal artery stenosis as a potential long-term sequela of radiotherapy. Conclusion: radiation-induced renal artery stenosis has only rarely been described in the ...

2008-09-01

Modulation of the intestinal response to ionizing radiation by anticoagulant and non-anticoagulant heparins.

A recent road test at LLNL underscored the zinc/air battery`s capacity to give electric vehicles some of the attractive features of gas-driven cars: a 400-km range between refueling, 10-minute refueling, and highway-safe acceleration. Developed at Lawrence Livermore National Laboratory, the battery weights only one-sixth as much as standard lead/acid batteries and occupies one-third the space, yet costs less per mile to operate. What`s more, because the battery is easily refuelable, it promises trouble-free, nearly 24-hour-a-day operation for numerous kinds of electric vehicles, from forklifts to delivery vans and possibly, one day, personal automobiles. The test of a Santa Barbara Municipal Transit bus with a hybrid of zinc/air and lead/acid batteries capped a short development period for the zinc/air battery. The test run indicated the zinc/air battery`s potential savings in vehicle weight from 5.7 to 4.0 metric tons, in battery weight from 2.0 to 0.3 metric ...

1995-10-01

Gel-based proteomics of liver cancer progression in rat.

Endothelial dysfunction is involved in radiation responses in many normal tissues, including intestine. Endothelium-directed interventions ameliorate intestinal radiation injury (radiation enteropathy) in animal models, and anecdotal reports also suggest a beneficial effect of heparin. This study assessed low molecular weight heparin as an intestinal radiation response modifier. Rats underwent localized small bowel irradiation. Groups of rats were treated with saline, nadroparin (3 mg/kg/d), or a non-anticoagulant heparin (SR80258, 3 mg/kg/d), from 3 days before to 2 weeks after irradiation. The intestinal radiation response was assessed 2 weeks and 6 weeks after irradiation using quantitative histology; morphometry, and cellular and molecular end-points. Compared to vehicle-treated controls, nadroparin significantly exacerbated structural radiation injury, neutrophil infiltration, and TGFbeta and collagen I immunoreactivity levels 2 weeks after irradiation. SR80258 was associated with ...

2005-11-01

GE's advanced nuclear reactor designs

A significant challenge in proteomics biomarker research is to identify the changes that are of highest diagnostic interest, among the many unspecific aberrations associated with disease burden and inflammation. In the present study liver tissue specimens (n=18) from six experimental stages were collected from the resistant hepatocyte (RH) rat model of liver cancer and analyzed by 2D DIGE. The study included triplicates of regenerating liver, control "sham-operated" liver, three distinct premalignant stages and hepatomas. Out of 81 identified proteins two-thirds were differentially abundant in rat hepatomas compared to control rat liver and, secondly, the majority of proteins were also changed in precursor stages. This underscores the importance of adequate control samples in explorative cancer biomarker research. We confirm several proteomic changes previously identified in human hepatocellular carcinoma (HCC) and we identify novel candidate proteomic aberrations ...

2011-06-06

Feasibility study for use of the natural convection shutdown heat removal test facility (NSTF) for VHTR water-cooled RCCS shutdown

The excess of US electrical generating capacity which has existed for the past 15 years is coming to an end as we enter the 1990s. Environmental and energy security issues associated with fossil fuels are kindling renewed interest in the nuclear option. The importance of these issues are underscored by the National Energy Strategy (NES) which calls for actions which open-quotes are designed to ensure that the nuclear power option is available to utilities.close quotes Utilities, utility associations, and nuclear suppliers, under the leadership of the Nuclear Power Oversight Committee (NPOC), have jointly developed a 14-point strategic plan aimed at establishing a predictable regulatory environment, standardized and pre-licensed Advanced Light Water Reactor (ALWR) nuclear plants, resolving the long-term waste management issue, and other open-quotes enabling conditions.close quotes GE is participating in this national effort and GE's family of advanced nuclear power ...

1993-07-01

Radionuclide Distribution Coefficients for Sediments Collected from Borehole 299-E17-21: Final Report for Subtask 1a

In summary, a scaling analysis of a water-cooled Reactor Cavity Cooling System (RCCS) system was performed based on generic information on the RCCS design of PBMR. The analysis demonstrates that the water-cooled RCCS can be simulated at the ANL NSTF facility at a prototypic scale in the lateral direction and about half scale in the vertical direction. Because, by necessity, the scaling is based on a number of approximations, and because no analytical information is available on the performance of a reference water-cooled RCCS, the scaling analysis presented here needs to be 'validated' by analysis of the steady state and transient performance of a reference water-cooled RCCS design. The analysis of the RCCS performance by CFD and system codes presents a number of challenges including: strong 3-D effects in the cavity and the RCCS tubes; simulation of turbulence in flows characterized by natural circulation, high Rayleigh numbers and low Reynolds numbers; validity of heat transfer ...

Antimalarial activity of selected Sudanese medicinal plants with emphasis to Maytenus senegalensis

Over 360 distribution coefficients (KJ for cesium, iodine, selenium, Strontium, technetium, and uranium were measured in fiscal year 1998 using 20 sediments collected fkom borehole 299-El 7-21 on the Hanford Site as part of the Immobilized Low-Activity Waste-Performance Assessment (ILAW-PA). Additionally, the pH and cation-exchange capacity (a measure of the total quantity of cations that a sediment can adsorb) of these sediment samples were measured. The sediment samples originated from the Hanford formation (informal name). Statistical analyses, using Student's t-test and correlation were conducted with the measured values. There were no significant differences between layers 1 and 2 for the selenium, strontium, technetium, and uranium & values (statistics could not be applied to evaluate layer 3 &values). Significant differences between the cesium and iodine&values for layem 1 and 2 were observed. However, these differences were modest and would likely not ...

1998-10-14

Contrasting Diffusion Patterns for PC and Mobile Videos: A User-Centric View of the Influencing Factors

The aim of the present study is to identify and characterize the antimalrial agents from traitional Sudanese medicinal plants. 49 plants parts representing 26 species from 15 families were extracted and screened for their in vitro antimalrial activity using P. falciparum strain 3D7 which is chloroquine sensitive and Dd2 strain which is chloroquine resistant and pyrimethamine sensitive.The plant species investigated exhibited diverse botanical families. They includes Annonaceae, Aristolochiaceae, Asteraceae, Balantiaceae, Caesalpiniceae, Celasteraceae, Cucurbitaceae, Fabaceae, Graminae, Meliaceae, Myrtaceae, Polygonaceae, Rubiaceae, Rutaceae, and simaroubaceae. The evaluation of these plants for their antimalarial activity and their effect on lymphocyte proliferation was carried out. 57 extracts were tested on the chloroquine sensitive strain (3D7). Where 34 extracts (59%) exhibited significant activity against 3D7 with IC_5_0 values #100 #mu# g/ml), where as ...