Quantitative structure activity relationship (QSAR) analysis of the correlations between initial brain uptake and structure parameters, for example lipophilicity F_r, molar refractivity MR and electronic parameters #sigma#_1 of the "9"9Tc"m-N_2S_2 complexes have been studied with multiple regression analysis method. The main structural factors which affect the initial brain uptake of this kind of brain imaging agents have been discussed. The results may give some theoretical information for designing new brain imaging agents
There are many factors that can influence glucose uptake by contracting skeletal muscle during exercise and although one may be intramuscular glycogen content, this relationship is at present not fully...Full Text Available
Ozone is the most important regional-scale air pollutant causing risks for vegetation and human health in many parts of the world. Ozone impacts on yield and quality of crops and pastures depend on precursor emissions, atmospheric transport and leaf uptake and on the plant?s biochemical defence capacity, all of which are influenced by changing climatic conditions, increasing atmospheric CO2 and altered emission patterns. In this article, recent findings about ozone effects under current conditions and trends in regional ozone levels and in climatic factorsaffecting the plant?s sensitivity to ozone are reviewed in order to assess implications of these developments for future regional ozone risks. Based on pessimistic IPCC emission scenarios for many cropland regions elevated mean ozone lev...
This report describes experimental results for the selective removal of strontium and cesium from simulated waste solutions using monosodium titanate (MST) and crystalline silicotitanate (CST)-laden filter cartridges. Four types of ion exchange cartridge media (CST and MST designed by both 3M and POROX{reg_sign}) were evaluated. In these proof-of-principle tests effective uptake of both Sr-85 and Cs-137 was observed. However, the experiments were not performed long enough to determine the saturation levels or breakthrough curve for each filter cartridge. POREX{reg_sign} MST cartridges, which by design were based on co-sintering of the active titanates with polyethylene particles, seem to perform as well as the 3M-designed MST cartridges (impregnated filter membrane design) in the uptake of strontium. At low salt simulant conditions (0.29 M Na{sup +}), the instantaneous decontamination factor (D{sub F}) for Sr-85 with the ...
BackgroundAdipose tissue lipid storage and processing capacity can be a key factor for obesity-related metabolic disorders such as insulin resistance and diabetes. Lipid uptake is...Full Text Available
BackgroundDespite concerns that facilitating informed choice would decrease diabetes screening uptake, 'informed choice' invitations that increased knowledge did not affect attendance...Full Text Available
Sodium-dependent high-affinity choline uptake was measured in various regions of the brains of rats irradiated for 45 min with either pulsed or continuous-wave low-level microwaves (2,450 MHz; power density, 1 mW/cm2; average whole-body specific absorption rate, 0.6 W/kg). Pulsed microwave irradiation (2-microseconds pulses, 500 pulses/s) decreased choline uptake in the hippocampus and frontal cortex but had no significant effect on the hypothalamus, striatum, and inferior colliculus. Pretreatment with a narcotic antagonist (naloxone or naltrexone; 1 mg/kg i.p.) blocked the effect of pulsed microwaves on hippocampal choline uptake but did not significantly alter the effect on the frontal cortex. Irradiation with continuous-wave microwaves did not significantly affect choline uptake in the hippocampus, striatum, and hypothalamus but decreased the uptake in the ...
This paper describes an investigation of electrodeposited Zn-14% Ni and aluminium-based SermeTel 1140/962 coatings as possible replacements for cadmium. Slow strain rate tests were performed to measure the extent of direct hydrogen embrittlement of a high strength steel substrate as a result of the coating process and of hydrogen re-embrittlement caused by coating corrosion. The level of re-embrittlement was shown to depend on both the electrochemical potential of the coating and its barrier properties. Zn-14% Ni coatings caused the most re-embrittlement as they had the most active potential and contained through-thickness defects which left the steel exposed to hydrogen uptake. The microstructure of the high strength steel was also shown to be an important factoraffecting the extent of embrittlement. AerMet 100 steel was more resistant than 300M steel and this was attributed to the presence of reverted austenite ...
Objectives1) To establish a protocol for transfection of immortalised type I cells with SiRNA and its effect on cell viability; 2) To optimise silencing of genes involved in endocystosis using SiRNA and confirm successful transfection with western blotting; 3) To investigate the effect of gene silencing on uptake of flourescently-labelled latex nanoparticles.DescriptionTo investigate the mechanisms of particle uptake.
The purpose of this article is to critically review the available evidence pertaining to occupational, environmental, and individual factors that can affect the development of occupational asthma (OA)....Full Text Available
Various factorsaffecting the aggregation of Actinomyces naeslundii strain 12104 were studied. When the pH of glucose-supplemented growth medium fell below 5.5, the cells aggregated and formed microbial...Full Text Available
Knowledge of factorsaffecting variation in birth weight is especially important given the relationship of birth weight to neonatal and adult health. The present study utilises two large contemporary...Full Text Available
The responses of ramets of hybrid poplar (Populus spp.) (HP) clones NE388 and NE359, and seedlings of red maple (Acer rubrum, L.) to ambient ozone (O_3) were studied during May-September of 2000 and 2001 under natural forest conditions and differing natural sunlight exposures (sun, partial shade and full shade). Ambient O_3 concentrations at the study site reached hourly peaks of 109 and 98 ppb in 2000 and 2001, respectively. Monthly 12-h average O_3 concentrations ranged from 32.3 to 52.9 ppb. Weekly 12-h average photosynthetically active radiation (PAR) within the sun, partial shade and full shade plots ranged from 200 to 750, 50 to 180, and 25 to 75 #mu#mol m"-"2 s"-"1, respectively. Ambient O_3 exposure induced visible foliar symptoms on HP NE388 and NE359 in both growing seasons, with more severe injury observed on NE388 than on NE359. Slight foliar symptoms were observed on red maple seedlings during the 2001growing season. Percentage of total leaf area ...
ObjectivesTo assess the distribution and risk factors of depleted uranium uptake in military personnel who had taken part in the invasion of Iraq in 2003.MethodsSector...Full Text Available
Selected samples of waste microbial biomass originating from various industrial fermentation processes and biological treatment plants have been screened for biosorbent properties in conjunction with uranium and thorium in aqueous solutions. Biosorption isotherms have been used for the evaluation of biosorptive uptake capacity of the biomass which was also compared to an activated carbon and the ion exchange resin currently used in uranium production processes. Determined uranium and thorium biosorption isotherms were independent of the initial U or Th solution concentration. Solution pH affected the exhibited uptake. 24 refs.
The effects of orthovanadate on the uptake of sucrose by Ricinus cotyledons and on sucrose-coupled proton influx were measured in order to gain insight into the relationship to the plasma membrane proton pump. Vanadate had no effect on short-term sucrose uptake. In long-term experiments (> 30 min) sucrose uptake was progressively inhibited, but only at high external sucrose concentrations. Vanadate did not affect proton efflux pumping in the absence of sucrose and neither did it change the initial rate of sucrose-coupled proton influx. However, it enhanced the maximal level of sucrose-induced alkalization of the medium at all sucrose concentrations tested. This is interpreted as an inhibiting effect of vanadate on the proton pump that recycles protons during sucrose-proton cotransport. The sensitivity towards vanadate indicates that this proton pump is an ATPase. A second proton-translocating system, ...
Radium is known to be taken up by aquatic animals, and tends to accumulate in bone, shell and exoskeleton. The most common approach to estimating the uptake of a radionuclide by aquatic animals for use in health and environmental risk assessments is the concentration factor method. The concentration factor method relates the concentration of a contaminant in an organism to the concentration in the surrounding water. Site specific data are not usually available, and generic, default values are often used in risk assessment studies. This paper describes the concentration factor method, summarizes some of the variables which may influence the concentration factor for radium, reviews reported concentration factors measured in marine environments and presents concentration factors derived from data collected in a study in coastal Louisiana. The ...
Radium is known to be taken up by aquatic animals, and tends to accumulate in bone, shell and exoskeleton. The most common approach to estimating the uptake of a radionuclide by aquatic animals for use in health and environmental risk assessments is the concentration factor method. The concentration factor method relates the concentration of a contaminant in an organism to the concentration in the surrounding water. Site specific data are not usually available, and generic, default values are often used in risk assessment studies. This paper describes the concentration factor method, summarizes some of the variables which may influence the concentration factor for radium, reviews reported concentration factors measured in marine environments and presents concentration factors derived from data collected in a study in coastal Louisiana. The ...
Before large-scale anthropogenetic emissions the environmental factors have been rather stable for thousands of years, varying yearly, seasonally and daily in rather regular manners around some mean values. In this century the emissions of CO{sub 2}, sulphur and nitrogen from society to atmosphere are changing both atmospheric and soil environment at rates not experienced before. The fluxes to soil affect the contents of plant available nutrients and solubility of toxic compounds in the forest soil. Additionally, the chemical state of soil environment is coupled to tree growth, litter production and nutrient uptake as well as to the activity of biological organisms in soil, which decompose litter and release nutrients from it. Trees have developed effective regulation systems to cope with the environment during the evolution. The resulting acclimations improve the functioning of the trees if the environmental ...
Crystalline silicotitanate inorganic ion exchanger, with a sitinakite structure is candidate material for remediation of aqueous nuclear waste streams. The syntheses of crystalline silicotitanate (CST) and Nb-substituted crystalline silcotitanate (Nb-CST) were carried out under hydrothermal conditions and the products were characterized using techniques viz., XRD, SEM/EDS, DTA/TGA, surface area respectively. Batch experiments were carried out to study the kinetics of uptake of 137Cs and 90Sr, to estimate the decontamination factor (DF) values and distribution coefficients (K d) for the above synthesized CST and Nb-CST samples from actual radioactive waste solutions. The DF values for uptake of Cs and Sr by Nb-CST after 24?h of equilibration was 355 and 136 whereas for CST it was found to b...
Bisaminoethanethiol (BAT) ligands with various gem-dimethyl and amide groups were prepared, and the corresponding neutral Tc-99m complexes were prepared and evaluated for their relative stabilities by ligand-exchange reactions. It was demonstrated that technetium complexes containing gem-dimethyl substituents have higher lipophilicities, whereas those with an amide group possess greater stability, which enhances ligand-exchange reaction. The most interesting observation was that the brain uptake in rats is not determined only by lipophilicity. Apparently, Tc-99m complexes with an amide functional group display lower brain uptakes in rats compared to those without an amide group. The brain uptake was strongly influenced by substituents on the BAT ligand. These factors are critically important and should be taken into consideration when designing Tc-99m-labeled agents for CNS receptor imaging.
The clinical use of "1"8F-fluorodeoxyglucose (FDG) positron emission tomography in monitoring anticancer treatment is expanding. At the same time a number of radiotracers aiming to image different aspects of tumour biology such as proliferation and apoptosis are being developed. However, the factors determining changes of radiotracer uptake parameters in response to treatment are not well understood. In many cases, cellularity may be the primary determinant of changes of FDG uptake and may confound the interpretation of metabolic changes. Early imaging assessments have in some cases showed transient increases of uptake parameters, commonly termed 'flares', which are likely to be unaffected by cellularity and directly reflect pharmacodynamics at a cellular level. In this review a number of settings where molecular imaging 'flares' have been described are discussed. Such changes may often be clinically ...
Biosorption of heavy metals by various biological materials has been studied extensively in the last decade due to its potential particularly in wastewater treatment. The presence of a large number of metals in industrial metal-bearing solutions makes it necessary to investigate their effect on the final metal uptake by individual biosorbent materials. Nonliving biomass of Sargassum, a brown marine alga, is capable of binding more than 10% of its dry weight in toxic cadmium ions. Although ubiquitous iron interferes with Cd uptake, only approximately 4.5% of it is sequestered (biomass dry weight). Biosorption of both metals at pH 4.5 could be described by Langmuir-type isotherms with b, the affinity-related coefficient (Cd: b = 0.015; Fe: b = 0.027). The interference of Fe with Cd uptake, and vice versa, was assessed by deriving three-dimensional equilibrium two-metal sorption isotherm surfaces, smoothed and cut to reveal ...
Nutrient elements contained in litter fall flux, that of uptake flux and turnover rate had generally tended to increase with the increase in the Warmth Index, while the amount of nutrient in the A[sub 0] horizon and nutrient use efficiency did not. However, it is suggested that topographic and climatic aridity, and the amount of available and exchangeable phosphorus, calcium and magnesium greatly affect the nutrient dynamics in a each forest ecosystem as the Warmth Index increases. (J.P.N.).
BACKGROUNDThe reproductive health of children born of infertile couples may be affected by infertility treatment or factors associated with infertility. We examined sexual maturation...Full Text Available
Jan 22, 2011 ... Abstract: Land use changes and deforestation in tropical rainforests are among the major factorsaffecting the overall function of the global ...
... 2. Help women become accepted by providing job-related training, creating flexible work groups with good climates, and encourage supervisors to ...
... content of the environment) are significant factorsaffecting the useful service life of adhesive bonded plastic composite sandwich panels at 650 F ...
There is conflicting evidence about the effect of parental consanguinity on fetal growth. Previous studies have not always allowed for other factors that are known to affect birth weight, in particular,...Full Text Available
Interactions beween a high latitude, continental shelf, spring phytoplankton bloom and water column physics and chemistry were studied using /sup 15/N measured rates of nitrogen uptake. Peak bloom conditions commenced when the mixed layer shallowed and minimized respirational losses. Integrative light-mixing growth models were accurate during early bloom stages. An advection-diffusion model associated peak bloom nitrate uptake with pycnocline mixing rates of 2.1 m d/sup -1/ in an 18 m mixed layer. Maximum nitrogen specific uptake rates (hr/sup -1/), unlike those of carbon, coincided with peak bloom conditions. Although species compositions among peak bloom periods were similar, particulate C/N ratios were not. Apparently, both intercellular factors and prevailing mixing conditions influence specific uptake rates and cell composition. A large proportion of new (nitrate) to total ...
Opinions on factorsaffecting public power systems are presented. Social, economic, and political factors are discussed in terms of their impact on public power. Competition with investor-owned utilities is the primary focus of the paper. Privatization and regulations are other issues discussed.
BackgroundThe link between maternal factors and birth outcomes is well established. Substantial changes in society and medical care over time have influenced women's reproductive...Full Text Available
{sup 14}C-Sugar uptake and incorporation into starch by slices of developing maize (Zea mays L.) endosperm were examined and compared with sugar uptake by maize endosperm-derived suspension cultures. Rates of sucrose, fructose, and D- and L-glucose uptake by slices were similar, whereas uptake rates for these sugars differed greatly in suspension cultures. Concentration dependence of sucrose, fructose, and D-glucose uptake was biphasic (consisting of linear plus saturable components) with suspension cultures but linear with slices. These and other differences suggest that endosperm slices are freely permeable to sugars. After diffusion into the slices, sugars were metabolized and incorporated into starch. Starch synthesis, but not sugar accumulation, was greatly reduced by 2.5 millimolar p-chloromercuribenzenesulfonic acid and 0.1 millimolar carbonyl cyanide m-chlorophenylhydrazone. ...
Phlorizin is a competitive inhibitor of Na/sup +//glucose symport in animal cells and of H/sup +//3-O-methylglucose (3-O-MeG) symport in liverworts. The effects of this compound on the uptake of (U-/sup 14/C) sucrose and of (/sup 14/C) 3-O-MeG by broadbean (Vicia faba L.) leaf discs were studied. Leaf discs without lower epidermis were preincubated in the dark for 30 min (fresh discs) or for 12 h (aged discs) on a medium buffered at pH 5.0 containing mannitol as an osmoticum. They were then incubated for 30 min in the light on a similar solution added with 1 mM (/sup 14/C) sucrose or (/sup 14/C) 3-O-MeG and 5 mM phlorizin. Phlorizin inhibited uptake of 3-O-MeG by 37 and 50% respectively in fresh and aged discs. Sucrose uptake was more sensitive to the inhibitor than 3-O-MeG uptake and was also more inhibited in aged than in fresh discs (76% inhibition vs 54%). Kinetic studies showed that the inhibition ...
The uptake of sup(99m)Tc-methylenediphosphonate (MDP) in different parts of rat femur was simulated using a local three-space model for tracer transfer. The model consisted of bone blood, bone ECF-space and space for tracer deposition. The measured sup(99m)Tc-MDP concentration in the systemic blood and the local bone blood flow measured by /sup 131/I-macroaggregated albumin microspheres were used as input parameters. The measured blood flow values were 6.3, 3.1 and 15.3 ml/100 g/min for proximal, middle and distal femur, respectively. the model parameters that gave the best fit to measured sup(99m)Tc-MDP uptake curves in computer simulation showed that bone blood flow, volume of ECF-space, permeability surface area product and accretion constant from ECF-space to space for tracer deposition were highest in distal and lowest in middle femur. The values corresponded to peak extraction fractions of 0.38, 0.62, and 0.31 for proximal, middle and ...
The uptake of sup(99m)Tc-methylenediphosphonate (MDP) in different parts of rat femur was simulated using a local three-space model for tracer transfer. The model consisted of bone blood, bone ECF-space and space for tracer deposition. The measured sup(99m)Tc-MDP concentration in the systemic blood and the local bone blood flow measured by "1"3"1I-macroaggregated albumin microspheres were used as input parameters. The measured blood flow values were 6.3, 3.1 and 15.3 ml/100 g/min for proximal, middle and distal femur, respectively. the model parameters that gave the best fit to measured sup(99m)Tc-MDP uptake curves in computer simulation showed that bone blood flow, volume of ECF-space, permeability surface area product and accretion constant from ECF-space to space for tracer deposition were highest in distal and lowest in middle femur. The values corresponded to peak extraction fractions of 0.38, 0.62, and 0.31 for proximal, middle and distal ...
Autophagy is a regulated catabolic process triggered in cells deprived of nutrients or growth factors that govern nutrient uptake. Here we report that autophagy is induced by cetuximab, a therapeutic...Full Text Available
Objectives: To minimize movement artifacts during tracer imaging studies, the animals are generally sedated. Although many reports describe the effect of barbiturates on brain function, less is published about the general impact on the extracerebral metabolism and tracer biodistribution. This report describes the influence of pentobarbital on tumor uptake of ["1"2"3I]-2-iodo-L-phenylalanine (["1"2"3I]-2I-L-PA) using dissection and nuclear imaging. Methods: R1M tumor-bearing athymic mice were divided into two populations: untreated and pentobarbital-treated. Each group was subjected to dynamic and static planar imaging and organ dissection after ["1"2"3I]-2I-L-PA injection. Two-compartment blood modeling was performed. Analysis of variance (ANOVA), t test and clustered boxplot analyses were used to compare the results between the treatment groups and between the data acquisition methods. Results: Two-compartment blood modeling demonstrated that pentobarbital ...
L-[3-"1"8F]-#alpha#-methyltyrosine ("1"8F-FMT) is an amino-acid tracer for positron-emission tomography (PET). We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with "1"8F-FMT and 2-["1"8F]-fluoro-2-deoxy-D-glucose ("1"8F-FDG) uptake in patients with non-small cell lung cancer (NSCLC). Thirty-seven NSCLC patients were enrolled in this study, and two PET studies with "1"8F-FMT and "1"8F-FDG were performed. Uptake of PET tracers was evaluated with standardized uptake value. Vascular endothelial growth factor (VEGF), CD31, CD34, L-type amino acid transporter 1 (LAT1) and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical staining, and correlated with the clinicopathologic variables and the uptake of PET tracers. The median VEGF rate was 45% (range, 10-78%). High expression was seen in 30 patients (81%, 30/37). VEGF ...
This report summarises nearly 20 biosphere reports and gives a synthesis of the work performed within the SR-Site Biosphere project, i.e. the biosphere part of SR-Site. SR-Site Biosphere provides the main project with dose conversion factors (LDFs), given a unit release rate, for calculation of human doses under different release scenarios, and assesses if a potential release from the repository would have detrimental effects on the environment. The intention of this report is to give sufficient details for an overview of methods, results and major conclusions, with references to the biosphere reports where methods, data and results are presented and discussed in detail. The philosophy of the biosphere assessment was to make estimations of the radiological risk for humans and the environment as realistic as possible, based on the knowledge of present-day conditions at Forsmark and the past and expected future development of the site. This was achieved by using the ...
Based on the X-ray crystallographic data of Tc-complexes for brain imaging agents, geometry optimizations in vacuo of TcO-BAT, TcO-MAMA, TcO-L, L-ECD, TcN-BAT and TcN-L, L-ECD complexes are performed with Hartree-Fock method and LANL 2 DZ basis set of G98W program. Then solvation free energy for each Tc-complex mentioned above in water is calculated by polarizable continuum method (PCM) including models of CPCM and IEFPCM. The results show that solvation free energy of Tc-complex is not only an indicator of lipophilicity but also one of the important factors that influence the brain uptake
Dietary supplements of about 5 g/kg of a number of amino acids increased tissue lead concentrations in newly weaned rats but decreased them in older rats. The retention of both oral and intraperitoneal lead was affected. The uptake of "2"0"3Pb by tissues was reduced when methionine was given in the diet over a period of 5 weeks or when it or ethionine was given by mouth 24 h before the activity was measured. In the liver the fraction of the total activity found in the nuclei and mitochondria was increased by methionine, but in the kidney only the fraction found in nuclei was increased.
Bisaminoethanethiol (BAT) ligands with various gem-dimethyl and amide groups were prepared, and the corresponding neutral Tc-99m complexes were prepared and evaluated for their relative stabilities by ligand-exchange reactions. It was demonstrated that technetium complexes containing gem-dimethyl substituents have higher lipophilicities, whereas those with an amide group possess greater stability, which enhances ligand-exchange reaction. The most interesting observation was that the brain uptake in rats is not determined only by lipophilicity. Apparently, Tc-99m complexes with an amide functional group display lower brain uptakes in rats compared to those without an amide group. The brain uptake was strongly influenced by substituents on the BAT ligand. These factors are critically important and should be taken into consideration when designing Tc-99m-labeled agents for CNS receptor imaging.
In closed systems, the O2 compensation point (?O) was previously defined as the upper limit of O2 level, at a given CO2 level, above which plants cannot have positive carbon balance and survive. Studies with 18O2 measure the actual O2 uptake by photorespiration due to the dual function of Rubisco, the enzyme that fixes CO2 and takes O2 as an alternative substrate. One-step modelling of CO2 and O2 uptakes allows calculating a plant specificity factor (Sp) as the sum of the biochemical specificity of Rubisco and a biophysical specificity, function of the resistance to CO2 transfer from the atmosphere to Rubisco. The crossing points (Cx, Ox) are defined as CO2 and O2 concentrations for which O2 and CO2 uptakes are equal. It is observed that: (1) under the preindustrial atmosphere, photorespir...
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurobehavioral disorder affecting 5% to 10% of children. Although considered to be a highly familial disorder, ADHD heritability estimates of 60% to 80% highlight the considerable role that environmental factors may still play in disorder susceptibility. Proposed ADHD environmental risk factors include prenatal substance exposures, heavy metal and chemical exposures, nutritional factors, and lifestyle/psychosocial factors. This paper reviews the literature published in 2010 investigating the association between environmental risk factors and ADHD or related symptomatology. Sources of risk factor exposure and the proposed mechanism by which each exposure is linked to ADHD-related neurobehavioral changes are also reported. Metho...
Looking at all the indeterminate factors as a whole and regarding activity durations as independent random variables, the traditional stochastic network planning models ignore the inevitable relationship and dependence among activity durations when more than one activity is possibly affected by the same indeterminate factors. On this basis of analysis of indeterminate effect factors of durations, the effect factors-based stochastic network planning (EFBSNP) model is proposed, which emphasizes on the effects of not only logistic and organizational relationships, but also the dependent relationships, due to indeterminate factors among activity durations on the project period. By virtue of indeterminate factor analysis the model extracts and describes the quantitatively indeterminate effect f...
Ecosystems worldwide are experiencing unprecedented nitrogen enrichment through fertilization and pollution. While longterm ecological consequences are difficult to predict, it seems that plants and animals adapted to nitrogen-limited environments are at particular risk from these changes. This report summarizes the limited body of literature which addresses this important topic. From a herbivoreAes perspective, fertilization increases the nutritional quality of host plant tissues. In some cases fertilization has lead to decreased production of defensive compounds. How this affects populations of insects is unclear because fertilization affects not only herbivores but their natural enemies. This report outlines how fertilization affects tree processes such as growth, photosynthesis, and production of defensive compounds. The many factors that affect insect repsonse to fertilization ...
The protozoan parasite Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical infection that affects millions of people in the Americas. Current chemotherapy...Full Text Available
Ophthalmologic abnormalities have been described in patients with dementia, but the extent to which poor vision and treatment for visual disorders affect cognitive decline is not well defined. Linked...Full Text Available
The challenge to our profession today is to improve the quality of oral health while overcoming both extrinsic and intrinsic factors which may adversely affect our progress toward this goal. The combined...Full Text Available
From view on Organization Behavior theory, the concept, development and affectingfactors of safety culture are introduced. The focuses are on the establishment, development and management practice for safety culture at Daya Bay NPP. A strong safety culture, also demonstrated, has contributed greatly to improving performance at Daya Bay
The purpose of this prospective cohort study was to identify factors that place a dairy cow with uncomplicated milk fever (MF) at significant risk of becoming an alert downer cow (ADC) and to verify...Full Text Available
Factorsaffecting the membrane filtration of food suspensions were studied for 58 foods and 13 membrane filters. Lot number within a brand, pore size (0.45 or 0.8 micrometer), and time elapsed before...Full Text Available
On agar plates, daughter cells of Escherichia coli mutually slide and align side-by-side in parallel during the first round of binary fission. This phenomenon has been previously attributed...Full Text Available
The report discusses the capabilities of equipment vendors to supply and install the quantity of flue gas desulfurization systems required to meet alternative standards for coal-fired steam generators. It analyzes limiting factorsaffecting supply capabilities (such as the availa...
Certain structural and environmental factors other than technical combination of resources and firm size are hypothesized to affect medical practice output. Four groups of variables related to physician...Full Text Available
ObjectiveThe purpose of this study is to identify the factorsaffecting the failure of trials (<50% pain reduction in pain for trial period) to improve success rate of spinal...Full Text Available
Objective:This study examined the role of cognitive factors—such as expectancies regarding the consequences of not drinking and perceptions of peer drinking—in...Full Text Available
The influence of reconstituting a murine monoclonal IgG_1 antibody kit with pertechnetate Tc99m on antibody distribution in the liver, spleen and sternal bone marrow of patients was examined. The "9"9"mTc-labelled antibody used is directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen (CEA) and has been successfully applied for imaging tissue inflammation and bone marrow scanning. Radioactivity uptake was determined in the liver, spleen, bone marrow and a precordial background region in a consecutive series of 25 patients, examined with an antibody preparation, routinely radiolabelled according to the manufacturer's recommendations and in 14 patients, in whom the antibody was reconstituted with special care, avoiding bubble formation and dropping of buffer into the antibody-containing vial. Gentle compared with routine antibody reconstitution caused a highly significant reduction of the antibody uptake in the ...
BackgroundType 2 Diabetes mellitus (T2DM) affects persons of all ages, while also placing heavy economic burdens on national economies and healthcare systems. The study aims to investigate...Full Text Available
The uptake of "2"3"8U and "2"3"2Th in different parts of some selected plants used in traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia area) has been studied using two different types of solid state nuclear track detectors (SSNTDs) LR-115 type II and CR-39. Plant uptake of radionuclides is one of many vectors for introduction of contaminants into the human food chain. Thus, it is critical to understand soil-plant relationships that control nuclide bioavailability. Soil concentrations of uranium ranged from 6.10 to 11.62 ppm, with a mean of 7.90 ppm. Soil concentrations of thorium ranged from 2.70 to 4.80 ppm, with a mean of 3.41 ppm. Mean uranium specific activities were 8.38 Bq kg"-"1 in root tissue, 5 Bq kg"-"1 in stem tissue and 6.02 Bq kg"-"1 in leaf tissue. Mean thorium specific activities were 2.53 Bq kg"-"1 in root tissue, 1.64 Bq kg"-"1 in stem tissue and 1.96 Bq kg"-"1 in leaf tissue. The transfer ...
We have previously reported that FSH stimulates flux of 45Ca2+ into cultured Sertoli cells from immature rats via voltage-sensitive and voltage-independent calcium channels. In the present study, we show that this effect of FSH does not require cholera toxin (CT)- or pertussis toxin (PT)-sensitive guanine nucleotide binding (G) protein or activation of adenylate cyclase (AC). Significant stimulation of 45Ca2+ influx was observed within 1 min, and maximal response (3.2-fold over basal levels) was achieved within 2 min after exposure to FSH. FSH-stimulated elevations in cellular cAMP paralleled increases in 45Ca2+ uptake, suggesting a possible coupling of AC activation to 45Ca2+ influx. (Bu)2cAMP, however, was not able to enhance 45Ca2+ uptake over basal levels at a final concentration of 1000 microM, although a concentration-related increase in androstenedione conversion to estradiol was evident. Exposure of Sertoli cells to CT (10 ng/ml) ...
BackgroundComplaints of arm, neck and/or shoulders (CANS) affects millions of computer office workers. However its prevalence and associated risk factors in developing countries...Full Text Available
A variety of stress situations may affect the activity and survival of plant-beneficial pseudomonads added to soil to control root diseases. This study focused on the roles of the sigma factor AlgU...Full Text Available
This paper presents case studies of economic feasibility of solar photovoltaic systems using the software AVES-F (Analysis of Economic Feasibility of Photovoltaic Systems), developed by the authors, considering cases of stand-alone and grid-connected systems. The software takes into account several factors that can influence the economic feasibility of these kind of systems, like load to be supplied, distance to the grid, the use regime of the system, applied subsidies and others. The main goal of this paper is to analyze some of these factors and to observe how they can affect the economics of PV systems for electricity generation. (authors)
Under changing redox conditions some plants create plaques at their root surface, which may affect the mobility and uptake of As and heavy metals but it is unknown to what extent this also holds true for willows in contaminated floodplain soils. Therefore, willow roots were sampled from a phytoremediation trial in the contaminated floodplain of the river Elbe (Germany), cryofixed, freeze-dried, and cross sections were mapped for the distribution of As, Ca, Cu, Fe, K, Mn, Ni, S and Zn by synchrotron based X-ray fluorescence spectroscopy. The elements Ca, Cu, Ni, S and Zn were concentrated in the aerenchymatic tissue, and not associated with Fe and Mn. Mixed Fe-Mn plaques covered the surface of the willow roots and As was accumulated in these plaques. The observed association pattern between...
Abstract Objectives- Cyclodextrins are useful solubilizing excipients that have gained currency in the formulator's armamentarium based on their ability to temporarily camouflage undesirable physicochemical properties. In this context cyclodextrins can increase oral bioavailability, stabilize compounds to chemical and enzymatic degradation and can affect permeability through biological membranes under certain circumstances. This latter property is examined herein as a function of the published literature as well as work completed in our laboratories. Key findings- Cyclodextrins can increase the uptake of drugs through biological barriers if the limiting barrier component is the unstirred water layer (UWL) that exists between the membrane and bulk water. This means that cyclodextrins are mo...
To examine the hormonal regulation of the ATP-dependent Ca{sup 2+} pump in the kidneys, the ATP-dependent Ca{sup 2+} uptake by the basolateral membrane vesicles in the renal cortex was measured using radioactive calcium ({sup 45}Ca{sup 2+}) in rats with vitamin D deficiency or rats undergoing thyroparathyroidectomy. The V{sub max} of the Ca{sup 2+} pump activity was increased not only by administering calcitriol, but also by normalizing the serum calcium level in vitamin D-deficient rats. PTH suppressed the Ca{sup 2+} pump activity in normocalcemic vitamin D-deficient rats. Thyroparathyroidectomy did not affect the Ca{sup 2+} pump activity in the kidneys of normal rats. It was concluded that the ATP-dependent Ca{sup 2+} pump activity was depressed by secondary hyperparathyroidism in vitamin D-deficient rats. (author).
To examine the hormonal regulation of the ATP-dependent Ca"2"+ pump in the kidneys, the ATP-dependent Ca"2"+ uptake by the basolateral membrane vesicles in the renal cortex was measured using radioactive calcium ("4"5Ca"2"+) in rats with vitamin D deficiency or rats undergoing thyroparathyroidectomy. The V_m_a_x of the Ca"2"+ pump activity was increased not only by administering calcitriol, but also by normalizing the serum calcium level in vitamin D-deficient rats. PTH suppressed the Ca"2"+ pump activity in normocalcemic vitamin D-deficient rats. Thyroparathyroidectomy did not affect the Ca"2"+ pump activity in the kidneys of normal rats. It was concluded that the ATP-dependent Ca"2"+ pump activity was depressed by secondary hyperparathyroidism in vitamin D-deficient rats. (author).
The U.S. Department of Energy's (DOE) Savannah River Site (SRS) is decommissioning many of its excess facilities through removal of the facility structures leaving only the concrete-slab foundations in place. Site-specific, risk-based derived concentration guideline levels (DCGLs) for radionuclides have been determined for a future industrial worker potentially exposed to residual contamination on these concrete slabs as described in Jannik. These risk-based DCGLs were estimated for an exposure area of 100 m2. During deactivation and decommissioning (D and D) operations at SRS, the need for area factors for larger and smaller contaminated areas arose. This paper compares the area factors determined for an industrial worker exposed to a concrete slab end-state for several radionuclides of concern at SRS with 1) the illustrative area factors provided in MARSSIM, 2) the area correction factors provided in ...
The purpose of organization and management development activities in the commercial nuclear power industry is to foster high levels of power plant performance and safety through improved human performance. The NRC has been working to develop assessment tools to assay the effects of organizational factors on plant safety. The utility industry has been working on initiatives targeting individual accountability, the improvement of plant performance and the elimination of the items identified through the NRC assessment process. Organization and management activities do not focus on industry organizational charts, but on the personnel processes and dimensions (factors) that affect safety and economic performance. As individual terms these activities are often combined and referred to as organizational factors. As an area of study, organizational factors has become more prominent as the ...
The trace element selenium (Se) is required in the production of enzymes that protect mammalian cells from oxidative damage due to the byproducts of aerobic respiration. Its deficiency in livestock results in the nutritional muscular dystrophy called white muscle disease. This especially affects juveniles in the preweaning period. Symptoms have also been reported in wild herbivores on low-Se forage, and their appearance may be episodic, suggesting temporal variations in Se uptake by plants. Here, we report variations in selenium concentrations in Carex spp. sedges used as forage by bighorn sheep (Ovis canadensis) on summer range in the Wyoming, Wind River Mountains, and correlate those variations with soil conditions that affect the bioavailability of selenium. Variations in available Se are explained based upon the known oxidation/reduction chemistry of the element. It is concluded that water-saturated, alpine soils ...
Platinum complexes play an important role in the development of anticancer drugs. Their cytotoxicity can be influenced by the nature of the leaving ligands, due to the hydrolysis reaction that occurs prior to the binding of the platinum complex to DNA. Also, non-leaving groups such as lipophilic diamines may affect cellular uptake. In this work, we describe the synthesis of platinum(II) complexes having oxalato and long chain aliphatic N-alkyl ethylenediamines as ligands. The products were characterized by elemental analyses, infrared spectroscopy and {sup 1}H, {sup 13}C and {sup 195}Pt NMR spectroscopy. Biological activity was assessed against tumor cell lines (A{sub 549}, B16-F1, B16-F10, MDA-MB-231) and non-tumor cell lines (BHK-21 and CHO). The length of the carbon chain affects the cytotoxicity and the oxalato complexes were less cytotoxic than the respective chloride-containing analogues. (author)
The visual impact of wind turbines is one of the main factorsaffecting public acceptance of wind parks. This paper evaluates the visual impact of a wind park in Chania, Crete, using the Spanish method of evaluation. The outcomes are combined with the psychometric testing of the residents by the use of questionnaires and with the values of the Spanish method about various scenarios concerning the size of the wind park (double, half, one wind turbine). The results of the study prove that the quantification of the potential visual impact could minimize this, apparently, main reason that affects public acceptance. (author)
Typhoons Aere (2004) and Matsa (2005) caused high nephelometric turbidity in the Shihmen reservoir in northern Taiwan, jeopardizing the operation of the reservoir for several days, and ultimately impacting the living conditions and economy of the downstream residents. The torrential rains caused landslides and debris flows in upland areas, and flowed into riverbeds, likely contributing significantly to the suspended sediment yields in the reservoir. This investigation elucidates how upland landslides affect sediment attributes in the reservoir basin. Study methods including field observations, spatial analysis in GIS and aerial photo interpretation are adopted to trace the sediment sources and contributing factors to the landslide. Torrential rains induced landslides and debris-flows uplan...
The hypothesis that intracellular Ca/sup 2 +/ is an essential component of the intracellular mechanism of insulin action in the adipocyte was evaluated. Cells were loaded with the Ca/sup 2 +/ chelator quin-2, by preincubating them with quin-2 AM, the tetrakis(acetoxymethyl) ester of quin-2. Quin-2 loading inhibited insulin-stimulated glucose transport without affecting basal activity. The ability of insulin to stimulate glucose uptake in quin-2-loaded cells could be partially restored by preincubating cells with buffer supplemented with 1.2 mM CaCl/sub 2/ and the Ca/sup 2 +/ ionophore A23187. These conditions had no effect on basal activity and omission of CaCl/sub 2/ from the buffer prevented the restoration of insulin-stimulated glucose uptake by A23187. Quin-2 loading also inhibited insulin-stimulated glucose oxidation and the ability of insulin to inhibit cAMP-stimulated lipolysis without affecting ...
The hypothesis that intracellular Ca"2"+ is an essential component of the intracellular mechanism of insulin action in the adipocyte was evaluated. Cells were loaded with the Ca"2"+ chelator quin-2, by preincubating them with quin-2 AM, the tetrakis(acetoxymethyl) ester of quin-2. Quin-2 loading inhibited insulin-stimulated glucose transport without affecting basal activity. The ability of insulin to stimulate glucose uptake in quin-2-loaded cells could be partially restored by preincubating cells with buffer supplemented with 1.2 mM CaCl_2 and the Ca"2"+ ionophore A23187. These conditions had no effect on basal activity and omission of CaCl_2 from the buffer prevented the restoration of insulin-stimulated glucose uptake by A23187. Quin-2 loading also inhibited insulin-stimulated glucose oxidation and the ability of insulin to inhibit cAMP-stimulated lipolysis without affecting their basal activities. ...
Despite the proven utility of the Universal Soil Loss Equation (USLE) to predict soil rainfall erosion, it has limited precision in predicting soil loss in some soil series. Also, runoff is a factor in rainfall erosion and some models, such as the modified USLE (USLE-M), include runoff in predicting soil erosion. The soil erodibility factor is an essential component in both models and this may be affected by application of soil conditioners, such as polyacrylamide (PAM). The objectives of this study were to determine the effects of different rates of PAM (0, 1, 2, 4, and 6kgha-1) applied with sprinkler irrigation water, followed by two sprinkler irrigations with no PAM, on the erodibility of a loam soil under a rainfall simulator in a laboratory. The range of erodibility factor Ku obtained...
The purpose of this research is to clarify how psychological factors' impact on public acceptance of nuclear energy varies with where they live and their degree of knowledge. For this purpose, we carried out questionnaire survey about nuclear energy at three urban areas and two nuclear power plant siting areas. After collecting data, we applied factor analysis to the data, and found four factors which construct cognitive structure of nuclear energy. Using multiple regression analysis, we evaluated the impact of the four factors on two issues: the decision for or against nuclear policy and the reaction to nuclear power plant siting, and compared changes of the impact by where respondents live and their degree of knowledge. Consequently, we found that the impact of all four factors on the two issues varies with where respondents live. We also found that the impact of respondents' ...
The purpose of this research is to clarify how psychological factor's impact on public acceptance of nuclear energy varies with people's degree of knowledge. For this purpose, we carried out questionnaire survey about nuclear energy at Suginami ward, Tokyo. After collecting data, we applied factor analysis to the data, and found 4 factors: Trust in the Authorities, Superiority of Nuclear Power Generation, Benefit for Nuclear Power Plants' Siting Areas, and Risk Perception about Nuclear Technology. In addition, using multiple regression analysis, we evaluated the impact of the 4 factors on 2 issues: the decision for or against nuclear policy and the reaction to nuclear power plant siting. Consequently, we found the change of impact of all 4 factors on the 2 issues. Especially, the impact of the 4 factors to the reaction to nuclear power ...
The purpose of this research is to clarify how psychological factor's impact on public acceptance of nuclear energy varies with people's degree of knowledge. For this purpose, we carried out questionnaire survey about nuclear energy at Suginami ward, Tokyo. After collecting data, we applied factor analysis to the data, and found 4 factors: Trust in the Authorities, Superiority of Nuclear Power Generation, Benefit for Nuclear Power Plants' Siting Areas, and Risk Perception about Nuclear Technology. In addition, using multiple regression analysis, we evaluated the impact of the 4 factors on 2 issues: the decision for or against nuclear policy and the reaction to nuclear power plant siting. Consequently, we found the change of impact of all 4 factors on the 2 issues. Especially, the impact of the 4 factors to the reaction to nuclear power plant siting was ...
The major bottleneck for popularization and utilization of the conventional mechanical valve pulse combustors is the self-priming mode of gas supply. An aerodynamic valve (as against mechanical valve) self-excited pulse combustor of the Helmholtz-type with continuous supply of gas and air was designed and a mathematical model was established in this paper. The theoretical model employed well-stirred reactor model and a single step Arrhenius chemistry, and took those factors which might affect the combustion stability into account. The factors include the variation of the mass rate of the reactants affected by the pressure in the combustion chamber, the convective and radiation heat loss in the combustion chamber, and the heat transfer and wall friction in the tailpipe. The effect of wall t...
Data were collected on 154 adoptive families with gay/lesbian and straight adoptive parents (154 parent respondents and 210 adolescent respondents). This study was principally interested in factorsaffecting adolescent attachment including parent sexual orientation, adolescent and parent life satisfaction, and parent level of relationship satisfaction with their adopted child as well as other key parent, child and adoption characteristics. The results suggest that higher level of adopted adolescent attachment to parents is not related to adoptive parent sexual orientation. Adolescent attachment to parents is related to adolescent life satisfaction; parent level of relationship satisfaction with their adopted child, number of placements prior to adoption, and adolescent's current age. Adole...
Transfer factors of "2"1"0Po from soil to parsley and mint have been determined. Artificial polonium isotope ("2"0"8Po) was used as a tracer to determine transfer factor of Po from soil to plant in pot experiments. Two plant growing systems were used for this study namely, an outdoor system and a sheltered system by a polyethylene tent. "2"0"8Po and "2"1"0Po were determined in soil and different parts of the studied plants (stem and leaf), using alpha spectroscopy. The results have shown that there was a clear uptake of "2"0"8Po by roots to leaves and stems of both plants. Higher values of transfer factors using the "2"1"0Po activity concentrations than the "2"0"8Po activity concentration were observed. Transfer factors of "2"1"0Po from soil to parsley varied between 20 x 10"-"2 and 50 x 10"-"2 and 22 x 10"-"3 and 67 x 10"-"3 in mint, while "2"0"8Po transfer ...
The health of professional bus drivers is a critical factor in their driving performance; any impairment may lead to undesired consequences. In an attempt to develop and prioritize health and wellness programs, this study investigates the factors significantly affecting the health conditions of professional bus drivers, as well as the strength of these factors. This study uses self-rated health as the examination measurement. This simple assessment is an inclusive measure of health status for judging health trajectory, and is highly associated with changes in functional ability, including perceived control over driving. This study evaluates driver responses of self-rated health with ordered response models that consider factors such as the driver reported health problems, physical and psychological conditions, demographic factors, driving experience, and working ...
Both soil and plant samples of nine different plant species grown in soils from southeastern China contaminated with uranium mine tailings were analyzed for the plant uptake and translocation of "2"3"8U, "2"2"6Ra and "2"3"2Th. Substantial differences were observed in the soil-plant transfer factor (TF) among these radionuclides and plant species. Lupine (Lupinus albus) exhibited the highest uptake of "2"3"8U (TF value of 3.7x10"-"2), while Chinese mustard (Brassica chinensis) had the least (0.5x10"-"2). However, in the case of "2"2"6Ra and "2"3"2Th, the highest TFs were observed for white clover (Trifolium pratense) (3.4x10"-"2) and ryegrass (Lolium perenne) (2.1x10"-"3), respectively. "2"3"2Th in the tailings/soil mixture was less available for plant uptake than "2"2"6Ra or "2"3"8U, and this was especially evident for Chinese mustard and corn (Zea mays). The root/shoot (R/S) ratios obtained for ...
Sucrose uptake by discs of mature sugar beet root tissue incubated in [14C]-sucrose exhibited nonsaturating kinetics over the concentration range of 1 to 500 millimolar. Uptake was inhibited...Full Text Available
The uptake of nitrite into intact pea chloroplasts was observed and its relationship with internal nitrite reduction was assessed. Net nitrite uptake exhibited saturation kinetics and an alkaline pH...Full Text Available
Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system...Full Text Available
We studied two-photon exchange for elastic electron-proton scattering at low Q{sup 2}. Compact approximate formulas for the amplitudes were obtained. Numerical calculations were done for Q{sup 2}{<=}0.1 GeV{sup 2} with several realistic form factor parametrizations, yielding similar results. They indicate that the corrections to the magnetic form factor can visibly affect the cross-section and proton radii. For low-Q{sup 2} electron-neutron scattering two-photon exchange corrections were shown to be negligibly small00.
A new empirical expression is presented for the T/sub c/ of A-15 compounds, T/sub c/ = 210 2R/sub A/-d/sub 0//R/sub B/..sqrt..M/sub A/ x R/sup 3//sub A/g-barZ-bary/sub B//RB/R/sup 3//sub B/n-baray/sub A//R/sub A/, from which the effects of some structural factors on T/sub c/ for high-T/sub c/ superconductors are obvious.
The main objective of this paper is to identify conditions which affect public concern (either increase or decrease) and political acceptance for developing and implementing programmes for geologic disposal of long-lived radioactive waste. It also looks how citizens and relevant actors can be associated in the decision making process in such a way that their input is enriching the outcome towards a more socially robust and sustainable solution. Finally, it aims at learning from the interaction how to optimise risk management addressing needs and expectations of the public and of other relevant stakeholders. In order to meet these objectives, factors of relevance for societal acceptance conditions are identified, described and analysed. Subsequently these factors are looked for in the real world of nuclear waste management through cases in several countries. The analysis is conducted for six stages of a repository programme ...
... Accession Number : AD0749455. Title : Uptake and Retention of Adenine Moiety by Stored Human Red Blood Cells. Descriptive Note : Interim rept.,. ...
Describes general trends in the quality of rural education: equivalent rural and urban performance on national standardized tests and high school graduation rates but continuing rural deficits in college attendance and teacher qualifications. Discusses the below-average performance of southern rural schools, factorsaffecting rural students' college attendance, and the influence of changing labor markets. (SV)
Presented are some preliminary studies made in preparation for the design of a solar powered loop for desalination by humidification - dehumidification process. The studies concentrated on the evaluation of different parameters affecting the performance of the combination of different components in such a loop in the hope of outlining the most decisive factors for the choice or design of solar collectors or heat source. The results presented relate to the performance of two of the most important components in a loop of such purpose, that is: the humidifying and the dehumidifying columns or stacks. 4 refs.
A near-field microscope which operates in the rf/microwave frequency range is described. In this microscope, a scanning tunneling microscope (STM)-like tip rather than an aperture is used as a point-like evanescent field emitter. A spatial resolution of {approximately}5 {mu}m ({approximately}{lambda}/100000) is achieved in the current version. The design of the microscope as well as the principal factors which affect its performance are discussed. {copyright} {ital 1996 American Institute of Physics.}
Addresses factorsaffecting rural education in Tasmania (Australia), including population trends, financial support, student enrollment, socioeconomic status of rural residents, and geographic isolation. Issues that need to be addressed include the status of small schools in Tasmania, costs associated with transporting students, staffing, low student retention, and limited availability of special services. (LP)
The degradation of chlorinated solvents by reduction at the surface of zero-valent metals and bimetallic systems has emerged as an important approach to the in-situ remediation of ground water. Reduction by iron metal was studied in batch and column systems to develop a mechanistic understanding of the reaction chemistry and to determine the factors that affect dechlorination rate and long term performance in field applications.
Friction opposes tooth motion whenever sliding mechanics is employed. Understanding what friction is and how to manage it is of paramount importance to the successful practitioner. In this article, the coefficients of friction are summarized between different arch wire-bracket couples as a function of material, geometric, and external parameters. From this vantage point, friction can then be evaluated within the context of other factors that affect sliding-binding and notching. PMID:9573878
The ductility of extruded heavy-section Ti-base--Mo--V--Fe--Al alloy was studied. Metallographic evidence for the large effect of grain size on ductility is presented. Fracture was found to occur in large-grain material after less deformation than in smaller grain size specimens.
This paper reviews the main studies on entrepreneurship conducted during the past two decades that are relevant for the understanding of various macroeconomic issues. I organize the discussion by distinguishing three groups of contributions. The first group includes studies whose main purpose is to understand the factors that affect the decision to become an entrepreneur. The second group includes studies that look at the aggregate and distributional implications of entrepreneurship for savings and investment. The third group deals with issues of economic development and growth.
...food waste recycling schemes; (3) Six in-depth site visits to authorities operating collection schemes in order to capture information on scheme design, operational issues and factorsaffecting public engagement. The case study areas were: Bexley, Cambridge, Fenland, Hackney, Taunton Deane and Weymouth & Portland;...
Cystic fibrosis (CF) is a monogenic disease characterized by a high variability of disease severity and outcome that points to the role of environmental factors and modulating genes that shape the course...Full Text Available
the medium to long freezing range alloys of aluminum such as A356, A357, A206, 319 for example are known to exhibit dispersed porosity, which is recognized as a factoraffecting ductility, fracture toughness, and fatigue resistance of light alloy castings. The local thermal environment, for example, temperature gradient and freezing from velocity, affect the mode of solidification which, along with alloy composition, heat treatment, oxide film occlusion, hydrogen content, and the extent to which the alloy contracts on solidification, combine to exert strong effects on the porosity formation in such alloys. In addition to such factors, the availability of liquid metal and its ability to flow through the partially solidified casting, which will be affect by the pressure in the liquid metal, must also be considered. The supply of molten metal will thus be controlled by the volume of ...
The aim of this paper is to present and evaluate control strategies for adjustment and preservation of air quality, thermal and visual comfort for buildings' occupants while, simultaneously, energy consumption reduction is achieved. Fuzzy PID, fuzzy PD and adaptive fuzzy PD control methods are applied. The inputs to any controller are: the PMV index affecting thermal comfort, the CO{sub 2} concentration affecting indoor air quality and the illuminance level affecting visual comfort. The adaptive fuzzy PD controller adapts the inputs and outputs scaling factors and is based on a second order reference model. More specifically, the scaling factors are modified according to a sigmoid type function, in such a way that the measured variable to be as closer as possible to the reference model. The adaptive fuzzy PD controller is compared to a non-adaptive fuzzy PD and to an ON-OFF ...
Summaries are presented for those research contracts which expired between December 31, 1960 and December 31, 1981. Topics covered include: factors controlling distribution of fission products in biosphere, non-destructive methods of evaluating the U/sup 235/ and Pu content of irradiated fuel elements, studies of contamination in local marine resources, tracer studies of anemia, non-destructive analysis of irradiated fuel elements using a flux integrating monitor, mechanism of proteolysis of I/sup 131/-labeled fibrinogen, radiosensitivity of spermatogonia of Drosophila melel elements by gamma scanning, uptake and loss of radioactive material by marine bacteria, factors which influence the movement of radioactive strontium from soils to plants, biological concentration of fission products in mollusks from water, decay scheme of Tl/sup 210/, calcium balance in metabolic bone disease, development of ...
The purpose of this study was to prepare recombinant human epidermal growth factor (rhEGF) collagen sponges for topical applications and investigate the effects of different types of crosslinked collagen sponges as platforms for the controlled release of rhEGF. The microstructure and the drug release rates of collagen sponges were modified through treatment with different types (glutaraldehyde (GTA), genipin and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)), different concentrations of crosslinking agents and various preparation conditions. A controlled release profile was observed for the crosslinked collagen sponges as compared to the non-crosslinked ones. The results indicated that the GTA crosslinked sponges have the most potent controlling effect. As the amount of GTA increased, a greater rigidity of the collagen sponge structure combined with a lower hydrophilicity was observed, leading to a decreased drug release rate and an increased water ...
This paper addresses the major issues beginning teachers face in their first postings to rural areas in Australia. The issues go beyond pedagogy. Beginning teachers need to understand social factorsaffecting rural communities so they can link lessons to the realities experienced by students. Geographic isolation affects the provision of education in terms of time taken to travel, cost, terrain, and technology. Rural communities have groups that are socially isolated from each other and from the staff in schools. In order to teach effectively, teachers need to be aware of the social context of the community in which they live and work. Teachers in rural areas suffer from professional isolation and often confront teaching situations for which they have had little formal preparation. Communities in remote places often move quickly to adopt technological means to overcome their isolation. Teachers in rural areas need to ...
Abstract in english The main objective of the research presented here is to relate anatomical features of wood species that affect the interactions between polymeric phases and performance of wood plastic composites (WPC). These interactions are related to the probable interlocking volume and surface area for stress transfer in a WPC. Composites were produced from different wood species and analyzed using SEM (scanning electron microscopy). Results showed that wood species with high interfac (more) ial areas may increase mechanical interlocking, reflected in the viscous constant of the Maxwell model. A complicating factor is that the relation of cell wall thickness-lumen diameter and the interconnectivity between wood cells in a wood, affect the potential for cell collapse. When wood cells collapse, the penetration of the thermoplastic into the wood structure is almost always ceased. The collapse of wood cells during ...
BackgroundThe interactions between torus and several factors such as age, gender, and dental status have not been studied comprehensively. The purpose of this study was to determine the effect of gender on the mandibular cortical index (MCI) and to investigate a possible association between torus mandibularis (TM) and MCI.MethodsThe study consisted of 189 consecutive patients referred to Department of Oral Diagnosis and Radiology of Hacettepe University within 30 workdays. Patients who did not have systemic disorders affecting bone density were included; and the age, gender, dental status and existing TM of the patients were recorded. Morphology of the mandibular inferior cortex was determined according to Klemitti's classification on panoramic radiographs.ResultsMCI was affected by age and gender (P 0.05).ConclusionIn the study population, MCI was affected by age and gender. As age increased, ...
New interest by Australians in the state of rural education requires new understanding of factorsaffecting rural education and its related issues. Educational programs have not been flexible enough to cope with rural diversity, a key element in the milieu. Standards such as "equality of opportunity" and "uniformity" have been misapplied to rural Australian education, which is made distinctive by the inter-relatedness of many factors. Three dimensions of isolation are discussed: (1) types of isolation (geographic, cultural, social, and professional isolation); (2) ways of coping with isolation (understanding isolation, developing a sense of community, developing awareness of options, training the isolated, application, and technology); and (3) conditions affecting educational changes in isolated communities (social and political climate, pedagogy, finance, and incentives for change). All these concerns ...
A fermentation waste, Corynebacterium glutamicum, was successfully employed as a biosorbent for Reactive Black 5 (RB5) from aqueous solution. This paper initially studied the effect of pretreatment on the biosorption capacity of C. glutamicum toward RB5, using several chemical agents, such as HCl, H{sub 2}SO{sub 4}, HNO{sub 3}, NaOH, Na{sub 2}CO{sub 3}, CaCl{sub 2} and NaCl. Among these reagents, 0.1 M HNO{sub 3} gave the maximum enhancement of the RB5 uptake, exhibiting 195 mg/g at pH 1 with an initial RB5 concentration of 500 mg/l. The solution pH and temperature were found to affect the biosorption capacity, and the biosorption isotherms derived at different pHs and temperatures revealed that a low pH (pH 1) and high temperature (35 deg. C) favored biosorption. The biosorption isotherm was well represented using three-parameter models (Redlich-Peterson and Sips) compared to two-parameter models (Langmuir and Freundlich models). As a result, ...
Statements about the dynamic processes of uptake, transport, and deposition of Ca and Mg in norway spruce and Scots pine are made in this paper. Concerning the storage of these elements it is shown that there are great differences in their functional importance in cell metabolism. There is evidence that the role of Mg in enzyme and protein metabolism is of far greater significance for the understanding of Mg-deficiency symptoms than its function as the central atom of the chlorophyll complexes. In regard to the transport and especially to the incorporation of Ca into the needles differences between species were evident, expressing the special status of pine among the gymnosperms. With increasing needle age an accumulation of Ca-oxalate crystals, which are physiologically inert, could be proved for the studied conifers. This was interpreted as a 'detoxication' from surplus Ca to hold constant the level of the physiologically active fraction. Accordingly, the low ...
Norepinephrine stimulates the growth of a range of bacterial species in nutritionally poor SAPI minimal salts medium containing 30% serum. Addition of size-fractionated serum components to SAPI medium indicated that transferrin was required for norepinephrine stimulation of growth of Escherichia coli. Since bacteriostasis by serum is primarily due to the iron-withholding capacity of transferrin, we considered the possibility that norepinephrine can overcome this effect by supplying transferrin-bound iron for growth. Incubation with concentrations of norepinephrine that stimulated bacterial growth in serum-SAPI medium resulted in loss of bound iron from iron-saturated transferrin, as indicated by the appearance of monoferric and apo- isoforms upon electrophoresis in denaturing gels. Norepinephrine also caused the loss of iron from lactoferrin. The pharmacologically inactive metabolite norepinephrine 3-O-sulfate, by contrast, did not result in iron loss from transferrin or lactoferrin ...
One set of hypotheses offered to explain the decline of red spruce (Picea rubens Sarg.) in eastern North America focuses on the effect of acidic deposition on soil chemistry changes that may affect nutrient availability and root function. Long-term soils data suggests that soil acidification has occurred in some spruce stands over the past 50 yr, with plant uptake and cation leaching both contributing to the loss of cations. Studies of tree ring chemistry also have indicated changes in Ca/Al and Mg/Al ratios in red spruce wood, suggesting increases in the ionic strength of soil solution. Irrigation studies using strong acid inputs have demonstrated accelerated displacement of base cations from upper horizons. Spruce-fir (Abies spp.) nutrient budgets indicate that current net Ca and Mg leaching loss rates are of the same order of magnitude as losses to whole tree harvest removals, spread out over a 50-yr rotation. For most cations, red spruce ...
Tree growth is mainly regulated by nitrogen (N) availability. Many plants exhibit enhanced growth and increased biomass or net primary productivity when exposed to higher atmospheric levels of carbon dioxide (CO_2), as N metabolism is regulated by signals that are derived from CO_2 metabolism. This study estimated N use by trees of 3 poplar species exposed for 3 years to free air CO_2 enrichment (FACE) in order to determine if CO_2 treatment affected the future N availability of the plantation. N uptake of fine roots and litter was measured throughout the first crop rotation. Results were then related to previously published variations in soil N content during the same period. Retranslocation from green leaves was studied, as well as processes determining N mobilization and immobilization. The study showed that elevated CO_2 concentrations significantly increased N-use efficiency, and decreased N concentrations in most plant tissues. However, ...
This project analyzes Nordic trends in the development and industrial uptake of green nanotechno-logy in construction. The project applies an evolutionary economic perspective in analyzing the innovation dynamics and firm strategies in the window value chains in three Nordic countries, Denmark, Finland and Sweden. Hence the project investigates two pervasive parallel market trends: The emergence of the green market and the emergence of nanotechnology. The analysis investigates how a traditional economic sector such as the construction sector reacts to such major trends. Conclusions are multiple, but among the most important are: Eco-innovation has become the perhaps most important driver for innovation in the construction sector. Search into eco-innovative business opportunities is intense among all companies along the three analyzed Nordic window chains. While we generally find a low uptake of nanotechnology in the construction sector in the ...
Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This leads to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate "1"6"6Ho-Hydroxyapatite ("1"6"6 Ho-HA) as potential radiopharmaceutical for the symptomatic treatment of chronic and acute arthritis. Materials and Methods: Holmiun-166 was produced by irradiation of Ho_2O_3 at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthesized. Its labelling and quality controls follows the internationally accepted procedures. An antigen's arthritis was induced to eight New Zealand rabbits with the "1"6"6 Ho-HA radiochemical being administered thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon ...
The K0.5 for intracellular sodium of the two forms of (Na ,K )-ATPase which exist in rat adipocytes has been determined by incubating the cells in the absence of potassium in buffers of varying sodium concentration; these conditions shut off the Na pump and allow sodium to equilibrate into the cell. The activity of (Na ,K )-ATPase was then monitored with YWRb /K pumping which was initiated by adding isotope and KCl to 5 mM, followed by a 3-min uptake period. Atomic absorption and SSNa tracer equilibration were used to determine the actual intracellular (Na ) under the different conditions. The K0.5 values thus obtained were 17 mM for alpha and 52 mM for alpha(+). Insulin treatment of rat adipocytes had no effect on the intracellular (Na+) nor on the Vmax of YWRb /K pumping, but did produce a shift in the sodium ion K0.5 values to 14 mM for alpha and 33 mM for alpha(+). This change in affinity can explain the selective stimulation of alpha(+) by insulin under normal ...
The present article describes a novel synthesis route for nano-sized goethite ({alpha}-FeOOH) using hydrazine sulphate as an additive. The X-ray diffraction (XRD) peaks of synthesized powder matched well with those of {alpha}-FeOOH. Transmission electron microscopy (TEM) showed the particles of irregular shape in the range of 1-10 nm. Batch adsorption experiments for fluoride uptake were performed to study the influence of various experimental parameters such as contact time (10 min to 7 h), initial fluoride concentration (10-150 mg L{sup -1}), pH (2-11.6) and the presence of competing anions. The time data fitted well to pseudo-second-order kinetic model. The fluoride removal passed through broad maxima in pH ranges of 6-8. High adsorption capacity of 59 mg g{sup -1} goethite was obtained. The isothermic data fitted well to Freundlich model. The presence of other ions namely chloride and sulphate adversely affected fluoride removal. Fluoride ...
The kinetics of "1"8F-fluorodeoxyglucose ("1"8F-FDG) in the monkey brain were monitored, and comparisons were made between the conscious state and when under ketamine and pentobarbital anesthesia. Rhesus monkeys were intravenously injected with "1"8F-FDG and followed by 60 min of PET scanning. In the conscious state, the "1"8F-FDG concentration reached a plateau 5 min after intravenous injection. Under ketamine anesthesia, the "1"8F-FDG concentration gradually increased with time in all monitored regions. At 60 min after injection, the concentration in the striatum was about 3.2 times greater than that in the conscious state, and about 4.5 times greater in the cerebral cortex. Under pentobarbital anesthesia, the "1"8F-FDG concentration in the occipital cortex was slightly lower. These findings demonstrate that "1"8F-FDG concentration in the monkey brain is significantly affected by anesthesia. The results also imply the existence of a short-term regulation ...
Benthic invertebrates can uptake metals through diffusion of free ion solutes, or ingestion of sediment-bound forms. This study investigated the efficacy of the metal chelating resin SIR 300TM in adsorbing porewater metals and isolating pathways of metal exposure. A field experiment (Botany Bay, Sydney, Australia) and a laboratory toxicity test each manipulated the availability of porewater metals within contaminated and uncontaminated sediments. It was predicted that within contaminated sediments, the resin would adsorb porewater metals and reduce toxicity to invertebrates, but in uncontaminated sediments, the resin would not significantly affect these variables. Whereas in the laboratory, the resin produced the predicted results, in the field the resin increased porewater metal concentrations of contaminated sediments for at least 34 days and decreased abundances of four macroinvertebrate groups, and richness in all sediments. These ...
This publication identifies conditions which affect (either increase or decrease) public concern for and political acceptance of the development and implementation of programmes for geological disposal of long lived radioactive waste. It also looks at how interested citizens can be associated in the decision making process in such a way that their input enriches the outcome of a more socially robust and sustainable solution. The publication also considers how to optimize risk management, addressing the needs and expectations of the public and of other relevant stakeholders. Factors of relevance for societal acceptance conditions are identified for the different stages of a repository programme and implementation process, from policy development to the realization of the repository itself. Further, they are described and analysed through case studies from several countries, illustrating the added value of broadening the technical dimension with ...
In recent years, cobia has become an emerging farmed species in Asia due to its quick growth and high economic value. This study collects biological and economic data affecting the economic performance of cobia farming in three countries, namely Taiwan, China, and Vietnam. The data are collected by questionnaire sampling and analyzed by multivariate statistical analysis in order to compare the key factorsaffecting the production and economy of cobia farming in these three countries. The results show that Taiwan, China, and Vietnam have significant differences in input intensities and profitability. China has the highest input intensity (3372.42?TWD/m3), as its high stocking density increases feed input. Taiwan has the highest unit input cost (103.44?TWD/kg), as the high quality of the pro...
The penetrance of Lebers hereditary optic neuropathy (LHON) in families with primary mitochondrial DNA (mtDNA) mutations is very complex. Matrilineal and nuclear genetic background, as well as environmental factors, have been reported to be involved in different affected pedigrees. Here we describe two large Chinese families that show a striking difference in the penetrance of LHON, in which 53.3% and 15.0% of members were affected (Pin vivo mitochondrial oxidative metabolism as described in a previous study. Evolutionary analysis failed to indicate any putatively pathogenic mutation that cosegregated with G11778A in these two pedigrees. Our results suggest that the variable penetrance of LHON in the two Chinese families is independent of both their mtDNA haplotype background and a seconda...
This paper analyzes the diffusion of mobile telecommunications services in Vietnam and examines how telecommunications regulation and potential substitute/complement services affect the growth of the number of mobile telephone subscribers. Using a logistic diffusion model, it is found that fixed telephone services are a complement while data services have a negative relation to mobile telephone services in Vietnam. As for regulation, the policy of introducing competition has been found to be the most effective in influencing the adoption of mobile services. Another important result is that the estimated potential market is roughly 76% of the total population. The findings suggest that suitable regulation that guarantees competition in the mobile telecommunications market in a developing co...
Some models anticipate that liberalized agricultural trade will lead to increased crop diversity, while other models make the opposite claim. These positions were explored in southwestern British Columbia, Canada where, between 1992 and 1998, government subsidies and other measures designed to protect horticultural farmers were lifted, exposing these farmers to foreign competition. Public hearings on the future of agriculture provided an opportunity to tap the knowledge and experience of people affected by this transition. Analysis of transcripts from these hearings, which was confirmed by industry data, shows that trade liberalization has led to the loss of the local fruit and vegetable processing industry. Stakeholders saw the loss as a major factoraffecting the choice of crops grown lo...
This is the first volume of a two-volume report. Volume 2 will be published at a later date. This report presents the results of a research project conducted by Brookhaven National Laboratory for the United States Nuclear Regulatory Commission, Office of Nuclear Regulatory Research. The purpose of the project was to develop a general methodology to be use in the assessment of the organizational factors which affect performance reliability (safety) in a nuclear power plant. The research described in this report includes the development of the Nuclear Organization and Management Analysis Concept (GNOMIC). This concept characterizes the organizational factors that impact safety performance in a nuclear power plant and identifies some methods for systematically measuring and analyzing the influence of these factors on safety performance. This report is divided into two parts; Part 1 presents an overview of ...
With using artificial neural networks (ANNs), an analytical study related to the heated length effect on critical heat flux (CHF) has been carried out to make an improvement of the CHF prediction accuracy based on local condition correlations or table. It has been carried out to suggest a feasible criterion of the threshold length-to-diameter (L/D) value in which heated length could affect CHF. And within the criterion, a L/D correction factor has been developed through conventional regression. In order to validate the developed L/D correction factor, CHF experiments for various heated lengths have been carried out under low and intermediate pressure conditions. The developed threshold L/D correlation provides a new feasible criterion of L/D threshold value. The developed correction factor gives a reasonable accuracy for the original database, showing the error of -2.18% for average and 27.75% for RMS, ...
Metal nanoparticles have many potential technological applications. Biological routes to the synthesis of these particles have been proposed including production by vascular plants, known as phytoextraction. While many studies have looked at metal uptake by plants, particularly with regard to phytoremediation and hyperaccumulation, few have distinguished between metal deposition and metal salt accumulation. This work describes the uptake of AgNO{sub 3}, Na{sub 3}Ag(S{sub 2}O{sub 3}){sub 2}, and Ag(NH{sub 3}){sub 2}NO{sub 3} solutions by hydroponically grown Brassica juncea and the quantitative measurement of the conversion of these salts to silver metal nanoparticles. Using X-ray absorption near edge spectroscopy (XANES) to determine the metal speciation within the plants, combined with atomic absorption spectroscopy (AAS) for total Ag, the quantity of reduction of Ag{sup I} to Ag{sup 0} is reported. Transmission electron microscopy (TEM) ...
Streptococcus pneumoniae colonizes the mucosal surface of the human upper respiratory tract. A colonization event is gradually cleared through phagocytosis by monocytes/macrophages that are recruited to the airway lumen. Here, we sought to define the bacterial and host factors that promote monocyte/macrophage influx and S. pneumoniae clearance using intranasal bacterial challenge in mice. We found that the recruitment of monocytes/macrophages required their expression of the chemokine receptor CCR2 and correlated with expression of the CCR2 ligand CCL2. Production of CCL2 and monocyte/macrophage recruitment were deficient in mice lacking digestion of peptidoglycan by lysozyme (LysM) and cytosolic sensing of the products of digestion by Nod2. Ex vivo macrophages produced CCL2 following bacterial uptake, digestion by LysM, and sensing of peptidoglycan by Nod2. Sensing of digested peptidoglycan by Nod2 also required the pore-forming toxin ...
The influence of sediment dwelling macroinvertebrates on fate and bioavailability of contaminants in freshwater systems was determined using the burrowing mayfly, Hexagenia limbata, as a representative benthic organism. Two series of experiments were conducted: the first to determine the effect of mayflies on movement of contaminants into sediment and organisms, and the second to examine the effect of mayflies on release of contaminants from sediments to the water column and their subsequent accumulation in fish. Concentrations of "1"4C labelled DDT, hexachlorobenzene (HCB), and dihexylphthalate (DHP) in water were 0.11 +/- 0.01, 0.062 +/- 0.005 and 0.006 +/- 0.007 ppb, respectively. Total mass of DHP in the burrow wall was about equal to mass on the surface, indicating that mayflies were capable of doubling the amount of DHP sorbed per unit surface area of sediment. Adsorption of contaminants from water pumped through mayfly burrows increased depth of penetration and mass of DDT, DHP, ...
Tilapia Nilotica were exposed to "1"4 C- carbofuran (125 MUg/1) and "1"4 C - lindane (80 MUg/1) for 96 h. Uptake period followed by 8 days depuration period. The bioconcentration factor (BCF) for carbofuran reached 32.4 at 12 h and 82 for lindane at 48 h. The amount of "1"4 C-activity found in fish treated with "1"4 C - carbofuran after the uptake period showed the following descending order: viscera > remaining parts > gills > muscles. In case of "1"4 C - lindane treated fish the recovered amount followed the order; remaining parts> viscera > gills muscles. During the depuration period, carbofuran residues taken up by fish were eliminated in 2 phases, an initial rapid phase followed by a slower gradual one. However, the rate of elimination in case of lindane was much slower especially during the first 2 days. At the end of the depuration period (8 days), the muscles (edible portion) contained 10% and 58% of ...
Background: Accountability demands are increasingly pushing school leaders to explore more data and do more sophisticated analyses. Data-driven decision making (DDDM) has become an emerging field of practice for school leadership and a central focus of education policy and practice. Purpose: This study examined principals' DDDM practices and identified the factors influencing DDDM using the theoretical frame of information use environments. Participants: Participants were 183 public high school principals in a Midwestern state. Research Design: The research design was cross-sectional survey research. Data Collection and Analysis: Survey instruments were developed and administered to principals. Structural equation modeling was conducted to determine what factors significantly affect principals' DDDM practices in different leadership dimensions. Findings: Principals used data more frequently in instructional and organization ...
Purpose - The purpose of this paper is to investigate the factors that affect the adoption of cloud computing by firms belonging to the high-tech industry. The eight factors examined in this study are relative advantage, complexity, compatibility, top management support, firm size, technology readiness, competitive pressure, and trading partner pressure. Design/methodology/approach - A questionnaire-based survey was used to collect data from 111 firms belonging to the high-tech industry in Taiwan. Relevant hypotheses were derived and tested by logistic regression analysis. Findings - The findings revealed that relative advantage, top management support, firm size, competitive pressure, and trading partner pressure characteristics have a significant effect on the adoption of cloud computing...
This article identifies the imperatives behind the need to move away from teaching based on the transmission of a lot of facts to teaching that enables students to become lifelong learners. It reminds us that the over-riding goal is an education process that maximizes the ability of teachers to teach well and of students to learn effectively. It argues that the necessary reform process can only be successful if the three components of an education programme--the curriculum, teaching strategies and assessment--are reformed simultaneously to ensure that each is designed to produce more effective teaching and learning. It points to the literature that tells us what we know about factorsaffecting student behaviour and, in particular, notes the crucial factor of student perception of the requirement of the assessment regime. It recommends that Biggs' model of constructive alignment is used as the organizing principle ...
Effect of different factors on survival of patients with Ewing sarcoma (20 people), primary bone reticulosarcoma (43) and myeloma (10) of pelvic bones, has been studied. Independently of the method of treatment, the rate of 3-year survival from reticulosarcoma start constituted (31.5+-7.1)%, Ewing sarcoma - (33.0+-10.8)%, myeloma - (36.0+-15.9)%. Index of 5-year survival in case of reticulosarcoma constituted (20.9+-6.4)%, Ewing sarcoma - (23.6+-11.0)%, myeloma - (36.0+-15.9)%. Improvement of delayed results after prophylactic therapy courses is pointed out. Degree of pelvic bone affection is of a very important prognostic value.
Purpose - Mobile phones have provided an opportunity for banking institutions to introduce new services to the public. The latest service, which is now available in Malaysian banking institutions, is the mobile phone credit card. The purpose of this paper is to provide a preliminary investigation of the factors that determine whether Malaysia's bank customers will use the new mobile phone credit card technology. Design/methodology/approach - This paper extends the applicability of the technology acceptance model (TAM) to mobile phone credit cards and includes "perceived credibility (PC)", the "amount of information about mobile phone credit cards (AIMCs)" and "perceived expressiveness (PE)", in addition to "perceived usefulness (PU)" and "perceived ease of use (PEOU)". Findings - The resul...
This paper reports that there are four combustion technologies upon which U.S. electric utilities are expected to rely for the majority of their future power generating needs. These technologies are pulverized coal- fired combustion (PC); coal-fired fluidized bed combustion (AFBC); coal gasification, combined cycle systems (CGCC); and natural gas-fired combined cycle systems (NGCC). The engineering and economic parameters which affect the choice of a technology include capital costs, operating and maintenance costs, fuel costs, construction schedule, process risk, environmental and site impacts, fuel efficiency and flexibility, plant availability, capacity factors, timing of startup, and the importance of utility economic and financial factors.
ALLEYNE G., HANCOCK C. & HUGHES P. (2011) Chronic and non-communicable diseases: a critical challenge for nurses globally. International Nursing Review58, 328-331 Background:- Chronic and non-communicable diseases (NCDs) are a growing and enormous challenge that faces countries across the world. Low- and middle-income countries are disproportionately affected. Contributory factors:- Three risk factors - tobacco use, poor diet (including excessive alcohol intake) and lack of physical activity - contribute to four major chronic diseases - cardiovascular, chronic obstructive pulmonary disease, diabetes and some cancers, which are responsible for over 50% of deaths worldwide. Potential solutions:- International governmental and non-governmental agencies are becoming increasingly concerned and ...
The study was conducted during 2000 to determine the role of various chemical plant factors viz., total minerals, nitrogen, fat contents, carbohydrate, macro an micro nutrients in the leaves of five genotypes of sugarcane i.e., BF-162, SPSG-26, L-118, CP-43/33 and CP-72/2086 by correlating the infestation of top borer, Scirpophaga Nivella F. at tillering stage. None of the genotype was found completely resistant to the pest. CP-43/33 and BF-162 proved susceptible and resistant varieties, respectively. Total mineral, manganese and copper contents did not show significant correlation with the pest infestation, whereas nitrogen, potassium, calcium, magnesium and ferrous contents played a positive and significant role. Phosphorous, carbohydrates, fats and zinc contents played a significant and negative effect on the pest infestation at tillering stage. (author)
The power?time curves of mice splenic lymphocytes growth at 37??C affected by ginsenoside Rh2 were determined by microcalorimetry using a 3114/3236 TAM air bioactivity monitor with ampoule mode. Then, the minimal inhibitory concentration (MIC) of Rh2 on splenic lymphocytes growth was determined by serial dilution method. From factor analysis (FA) on six quantitative thermokinetic parameters from the power?time curves, the activity of Rh2 on splenic lymphocytes could be quickly evaluated by analyzing the changes in the two main parameters: growth rate constant k, and maximum heat-output power, P m. The results showed that Rh2 had strong inhibitory activity on splenic lymphocytes growth, and this inhibitory activity was strengthened with increasing concentration of Rh2 in the concentration r...
Calibration-Free Laser-Induced Breakdown Spectroscopy (CF-LIBS) has been proposed several years ago as an approach for quantitative analysis of Laser-Induced Breakdown Spectroscopy spectra. Recently developed refinement of the spectral processing method is described in the present work. Accurate quantitative results have been demonstrated for several metallic alloys. However, the degree of accuracy that can be achieved with Calibration-Free Laser-Induced Breakdown Spectroscopy analysis of generic samples still needs to be thoroughly investigated. The authors have undertaken a systematic study of errors and biasing factorsaffecting the calculation in the Calibration-Free Laser-Induced Breakdown Spectroscopy spectra processing. These factors may be classified in three main groups: 1) experi...
Salamanders regenerate their appendages after amputation and nerves are required for this process. Experiments were designed to test the idea that one way nerves could affect blastema cell proliferation is by influencing the metabolism of extracellular matrix (ECM) components and to identify neurotrophic factors which promote blastema cell mitosis. Temporal and spatial differences of glycosaminoglycans (GAGs) synthesis is innervated and denervated limbs were examined. Hyaluronic acid (HA) was found to be the major GAG produced during the proliferative period and chondroitin sulfate during differentiation. Denervation reduced synthesis of both these components by half. Dorsal root ganglia and fibroblast growth factor (FGF), a brain-derived mitogen, similarly doubled GAG synthesis in cultured blastemas, the FGF-effect being primarily on HA production. Histochemical and autoradiographical results confirmed the biochemical ...
Cardiac contractile function is dependent on the integrity and function of the sarcolemmal membrane. Swimming exercise training is known to increase cardiac contractile performance. The purpose of the present study was to examine whether a swimming exercise program would alter sarcolemmal enzyme activity, ion flux, and composition in rat hearts. After approximately 11 wk of exercise training, cardiac myosin and actomyosin Ca2+-adenosinetriphosphatase (ATPase) activity was significantly higher in exercised rat hearts than in sedentary control rat hearts. Glycogen content was increased in plantaris and gastrocnemius muscles from exercised animals as was succinic dehydrogenase activity in gastrocnemius muscle of exercised rats in comparison to sedentary rat preparations. Sarcolemmal vesicles were isolated from hearts of exercise-trained and control rats. Sarcolemmal Na+-K+-ATPase and K+-p-nitrophenylphosphatase activities, Na+-Ca2+ exchange, and passive Ca2+ binding did not differ between ...
A brief overview is given of the geological characteristics of each region of the state as they relate to potential geothermal development. Those exploration methods which can lead to the siting of a deep exploration well are described. Requirements and techniques needed for drilling deeper higher temperature exploration and production wells are presented. Electrical generation, direct utilization, and indirect utilization are reviewed. Economic factors of direct use projects are presented. A general guide to the regulatory framework affecting geothermal energy development is provided. The general steps necessary to gain access to explore, develop, distribute, and use geothermal resources are outlined. (MHR)
The thermal degradation and crystallisation behaviours of polyamide12/isotactic polypropylene (PA12/PP) blends were studied. Effects of blend ratio and compatibiliser concentration on the thermal degradation properties of the blends were analysed. The activation energy for degradation in compatibilised and uncompatibilised blends computed using Horowitz-Metzger equation was reported. The blend ratio as well as the presence of compatibiliser has significant effect on the thermal stability of the blends. Phase morphology was found to be one of the decisive factors that affected the thermal stability of both uncompatibilised and compatibilised blends. Melting and crystallisation behaviours of the blends in the presence and absence of compatibiliser were evaluated. It was observed that blendin...
Extensive investigations and detailed analysis of the failure reason of 9DVN002ZV fan in Daya Bay Nuclear Power Station showed that the fan destroy was caused by the failure of non-drive end bear. The direct cause of this bearing' failure was its improper assembly caused by improper maintenance procedure, and the root cause was too small internal radial clearance after mounting. The factoraffecting bearing internal radial clearance, the relationship between clearance and operating life time and fan failure process were discussed. (authors)
This study was initiated to provide empirical data and analyses on the dam passage timing, travel rate, survival, and life history variation of fall Chinook salmon that are produced in the Clearwater River. The area of interest for this study focuses on the lower four miles of the Clearwater River and its confluence with the Snake River because this is an area where many fish delay their seaward migration. The goal of the project is to increase our understanding of the environmental and biological factors that affect juvenile life history of fall Chinook salmon in the Clearwater River. The following summaries are provided for each of the individual chapters in this report.
Indoor radon is a potential health hazard for the general public, especially in buildings with poor ventilation. A variety of dosemeters have been developed and used in surveys of radon concentration measurements. In this article the passive dosemeters which are based on solid state nuclear track detectors are reviewed. The principle of passive dosimetry and the factorsaffecting their performance are discussed. The characteristics of SSNTD materials in relation to their behaviour under different environmental conditions are tabulated and discussed. Results of radon surveys from selected studies are also presented. (Author).
A detailed examination of the aging processes that may take place in solid-dielectric extruded-type high voltage transmission cables under dry conditions is presented. Particular emphasis is placed on the aging process as affected by the separate and simultaneous action of four main aging factors, namely the electrical, mechanical and thermal stresses, and the physical and chemical environment. A number of pertinent aging models are considered and their validity and applicability to accelerated aging tests on solid-type transmission cables are discussed.
This paper presents a survey on public preferences in SE England for the use of wind, biomass and nuclear power in electricity generation. Using a labelled CE the perceived importance (value) to the public of distance and the energy options' impacts on biodiversity, emissions, land occupation and household cost was explored. Results suggest that impacts, technology name, demographic characteristics, attitudes towards the environment, knowledge and experience with the technologies were significant choice determinants. Considering the current debate about the development of nuclear power and biomass in UK and worldwide, this survey provides an insight into the factorsaffecting public acceptability
The various factors that affect the open-circuit voltage ([ital V][sub oc]) of a two-terminal GaInP[sub 2]/GaAs tandem cell are examined. These include a) an anomalous problem associated with the GaAs bottom cell and b) back surface passivation of the thin GaInP[sub 2] top cell. Solutions to these problems are presented and yield tandem [ital V][sub oc]s close to the practical theoretical limits.
The sensitivity of the primary circuit material was examined at the Mochovce and Dukovany NPPs. No significant sensitivity of the base material or the weld metal to the initiation of corrosion cracking was observed. Thermal aging was found to accelerate significantly the corrosion fatigue kinetics in the material of the heat affected zone. The threshold values of the double amplitudes of the stress intensity factor were below 8 MPa/m"2 for the materials examined, with a cycle asymmetry coefficient of 0.65. The tests revealed no appreciable sensitivity to general corrosion, pitting, or intergranular corrosion. (J.B.). 7 tabs., 26 figs., 11 refs.
The purpose of the chapter is to explain briefly the various considerations that enter into determining the general layout or arrangement of typical hydroelectric powerplants, pumping plants, and pumped-storage plants. Some of the important factors that affect or determine the location, type, and layout of the plant and the selection of the major items of equipment included in the installation are outlined in this chapter. The first consideration in the design of a powerplant, pumping plant, or pumped-storage plant is that it adequately perform its function and be structurally safe. The structure is also designed to give a pleasing architectural appearance.
Computer simulations of agricultural finance and management may be helpful to students preparing for agricultural careers. Simulations would provide problem definition and problem solving in realistic interactions with complex and ambiguous situations similar to those encountered in farming. The paper describes a major financial problem for farmers, explores the implications of that problem for students, and outlines a computer-based simulation model which would give students experience in dealing with the problem. Data sources for simulations, potentials of interactive exercises among students, and advantages of using real data with existing ambiguities are described. The board game "AGRICULTURE" is discussed as a prototype for simulation. (LFL)
We study uncertainties surrounding competition on business networks and board games. We investigate these uncertainties using concepts of fuzzy logic and game theory. We investigate how the payoff of the players is affected by a number of factors. These include the level of connectivity or number of links, the number of competitors, possible constraints on the networks and on the boards, as well as choice of strategy adopted by competitors. We introduce one fuzzy player in the game. This player uses fuzzy rules to make strategic decisions. We introduce learning to train and analyze how the fuzzy player adapts over time during the game.
A brief overview is given of the geological characteristics of each region of the state as they relate to potential geothermal development. Those exploration methods which can lead to the siting of a deep exploration well are described. Requirements and techniques needed for drilling deeper higher temperature exploration and production wells are presented. Electrical generation, direct utilization, and indirect utilization are reviewed. Economic factors of direct use projects are presented. A general guide to the regulatory framework affecting geothermal energy development is provided. The general steps necessary to gain access to explore, develop, distribute, and use geothermal resources are outlined. (MHR)
A large acceptance, high stopping power Bragg curve spectrometer has been developed for use in coincidence experiments with heavy ions. The electron collection fields are radial and position information is obtained from a resistive anode. The detector is 60 cm deep and operates at pressures of up to 2.5 atm of P-10 gas. It is mated to a scattering chamber which allows it to be moved out of plane during coincidence measurements. Factorsaffecting the performance of the detector are discussed, and results obtained with the detector are presented. (orig.).
A large acceptance, high stopping power Bragg curve spectrometer has been developed for use in coincidence experiments with heavy ions. The electron collection fields are radial and position information is obtained from a resistive anode. The detector is 60 cm deep and operates at pressures of up to 2.5 atm of P-10 gas. It is mated to a scattering chamber which allows it to be moved out of plane during coincidence measurements. Factorsaffecting the performance of the detector are discussed, and results obtained with the detector are presented. (orig.).
There is increasing pressure to operate laboratory facilities in environmentally and financially sustainable ways. A key factor in achieving this goal is careful consideration of how energy is used by the buildings' ventilation system, both for conditioning air supplied to the laboratories and the energy used moving air through the building. Traditionally, laboratory energy use is treated as an engineering concern within the scope of the building's overall design and operation. However, this approach limits the involvement of key stakeholders in many important decisions and can lead to unexpected safety concerns for the laboratory's users. We believe that a broad view of the parties affected by a laboratory building's operations is necessary to avoid having the various stakeholders working...
The global spread of HIV and AIDS has presented a major threat to development, affecting the health of the poor and many aspects of social and economic development. The greatest impact of the epidemic has been felt in sub-Saharan Africa, and Zambia ranks among the worst hit countries. The Free Basic Education Policy in Zambia upholds the right of all children to a universal basic education. This study explored staff and student perceptions of the impact of the epidemic on access to, and the quality of, basic education for AIDS-affected children, orphans and other vulnerable children (OVCs) in the Copperbelt Province of Zambia, where the HIV/AIDS prevalence rate ranges from 34 to 40%, and life expectancy has dropped to 33 years. Data were collected from education personnel in six districts of the Copperbelt with the highest prevalence of HIV and AIDS and from staff and students in six schools. The data indicated a range of ...
Secondary ischemic necrosis of femoral head due to loss of blood supply following to femoral neck fracture is well known. The regional distribution of bone-seeking radiopharmaceuricals in the skeleton can depend on a number of factors, but bone blood flow is a major physiological determinant of regional skeletal uptake of Tc-99m polyphosphate and bone imaging may thus be used for the evaluation of vascularity of the femoral head. The authors made a comparative study of scintigraphic findings and operative findings of 28 cases of femoral neck fracture treated at Kyung Hee University Hospital from April 1980 to May 1984. The results were as follows: 1. In 16 cases of proven avascular necorsis of femoral head, scintigraphy showed absent or decreased activity in 14 cases (87.5%), while radiography showed increased density in 10 cases (62.5%). 2. In 12 cases of proven vital femoral head, scintigraphy showed increased activity in 9 cases (75%) and ...
The adsorption capacity of radionuclides onto suspended sediment was experimented on each of the coastal seawater sampled around the Kori and the Wolsung nuclear power plant. During the experiment the quantity and size fraction of suspended sediment were adjusted and the seawater and sediment chemistry is approximated to the expected field condition. Because the sorption capacity depends on the specific minerals, ocean chemistry and radionuclide involved, it is necessary to analyze sediment mineralogy. Clay mineral is dominant in seabed mineral and suspended sediment as the result of x-ray diffraction. Radionuclide sorbed to silty-clay mineral can be rather transported to ocean than scavenged to seabed because of low quantity and fine grained suspended sediment in the coast around the Kori and the Wolsung. The result of adsorption examinations shows that {sup 139}Ce and {sup 51}Cr and {sup 110m}Ag are strongly sorbed to suspended particle, while {sup 137}Cs is less sorbed and {sup ...
The adsorption capacity of radionuclides onto suspended sediment was experimented on each of the coastal seawater sampled around the Kori and the Wolsung nuclear power plant. During the experiment the quantity and size fraction of suspended sediment were adjusted and the seawater and sediment chemistry is approximated to the expected field condition. Because the sorption capacity depends on the specific minerals, ocean chemistry and radionuclide involved, it is necessary to analyze sediment mineralogy. Clay mineral is dominant in seabed mineral and suspended sediment as the result of x-ray diffraction. Radionuclide sorbed to silty-clay mineral can be rather transported to ocean than scavenged to seabed because of low quantity and fine grained suspended sediment in the coast around the Kori and the Wolsung. The result of adsorption examinations shows that "1"3"9Ce and "5"1Cr and "1"1"0"mAg are strongly sorbed to suspended particle, while "1"3"7Cs is less sorbed and "6"0Co ...
Biomimetic vesicle media which can selectivity extract and concentrate heavy metals (e.g., Pb{sup 2+}) from dilute solutions of 5 ppm and less have been prepared. At a concentration of only 1% 2/v, these non-covalently assembled, unilamellar, surfactant vesicles provide approximately 1,000m{sup 2} of exposed membrane surface area per liter of suspension which gives rise to very rapid rates of metal ion extraction. To facilitate the selective transport of heavy metal ions through the ion impermeable vesicle wall, the vesicles are doped with lipophilic ionophores, both natural and synthetic. In addition, the metal chelating agent, nitrolotriacetate, is encapsulated in the aqueous vesicle core to provide the driving force for metal ion uptake and concentration. Concentration factors in excess of 1000 fold have been observed. Metal-sorbing surfactant vesicles measuring approximately 100 nm in diameter are stable and have been tested in a ...
To evaluate the success rates, long-term patency rates and factorsaffecting the patency rates of percutaneous transluminal angioplasty(PTA) and thrombolysis in the management of insufficient access during hemodialysis. Between January 1991 and March 1995, 37 insufficient shunts(23 native fistulae and 14 graft fistulae) were treated in 31 patients. PTA was performed in 24 shunts, and thrombolysis in 13;in seven of these latter, thrombolysois was followed by PTA. The success and long-term patency rates of PTA and thrombolysis were evaluated. Shunts were subdivided according to a patient's age, type and age of the shunt, and number and length of the stenosis, and the degree of residual stenosis and in each subgroup, patency rates was compared. The overall success rate of PTA and thrombolysis for insufficient hemodialytic access was 78.4%(29/37). The success rates of PTA and thrombolysis were 91.7%(22/24) and 53.8%(7/13), respectively. ...
Paraquat poisoning in mammals results in a characteristic lung lesion manifested principally as progressive pulmonary fibrosis. Paraquat is actively concentrated into the lung but the site of uptake remains undefined. A method is described for the autoradiographic localization of paraquat in rats. Preliminary evidence for the site of uptake implicates the bronchiol. (author).
1. The uptake and esterification to trigylceride of oleic acid in micellar form was studied in rat intestine in vitro. Sacs of the upper half of the everted intestine taken from bile...Full Text Available
The effect of A1-adenosine receptor antagonism via 8-cyclopentyl-1,3-dipropyl-xanthine (CPDPX) on the stimulation of skeletal muscle glucose uptake by...Full Text Available
In this study we use the multiple indicator dilution technique to outline the kinetic mechanisms underlying the uptake of rubidium, a cation which, in the steady state, is concentrated by hepatic parenchymal...Full Text Available
1 An in vitro technique is described for measuring the uptake of 86Rb by human erythrocytes. 2 Fifteen patients were treated with digoxin for atrial fibrillation and other fast arrhythmias. 3 86Rb uptake...Full Text Available
Based on in vitro rat and human hepatocyte uptake studies showing inhibition of warfarin uptake in the presence of the non-specific organic anion transporting polypeptide (OATP)...Full Text Available
Many plants are known to reduce the toxic effects of high soil boron (B) by reducing uptake of B, but no mechanism for limiting uptake has previously been identified. The B-tolerant cultivar of barley...Full Text Available
Electrostatic nature of plant plasma membrane (PM) plays significant roles in the ion uptake and toxicity. Electrical potential at the PM exterior surface (ψ0o) influences...Full Text Available
The interaction of long-chain fatty acids with cells is important for their uptake and metabolism, as well as their involvement in signalling processes. The majority of long-chain fatty acids circulating...Full Text Available
The measurement of thyroidal uptake of radioiodine using a gamma camera and computer is described. In 12 children there was good agreement with simultaneous measurements using a probe, while in a further 14 patients the uptake values were consistent with the clinical diagnosis. The technique should be especially useful for infants and small children.
Bone radiotracer uptake in renal osteodystrophy was investigated in 35 dialysis patients by correlating the results of quantitative bone scintigraphy with those of biochemical and bone morphometric studies. There were highly significant correlations (P < 0.001) between the total skeletal activity and the biochemical (iPTH and alkaline phosphatase), and histologic parameters of hyperparathyroidism. These clinical results strongly suggest that increased bone turnover i.e. hyperparathyroidism, rather than osteomalacia is the major cause of increased skeletal uptake in renal osteodystrophy.
Hydrogen uptake and embrittlement of tantalum by electrolytically produced hydrogen is investigated on samples of varying composition and type of pretreatment. Of decisive influence on the uptake of hydrogen are the oxide layers present on the tantalum surface. By contact with platinum group metals as alloying constituents, surface coatings or anodic protection, a protection of tantalum can be obtained depending on the experimental conditions.
Hydrogen uptake and embrittlement of tantalum by electrolytically produced hydrogen is investigated on samples of varying composition and type of pretreatment. Of decisive influence on the uptake of hydrogen are the oxide layers present on the tantalum surface. By contact with platinum group metals as alloying constituents, surface coatings or anodic protection, a protection of tantalum can be obtained depending on the experimental conditions. (orig.).
This study reports on the physical-chemical behaviour of swelling di-octahedral clays (smectites) and their interaction with aqueous solutions and bacteria (Shewanella putrefaciens). Experimental results are presented for compacted clays, hydrated under confined volume conditions, using a new type of reaction-cell (the 'wet-cell' of Warr and Hoffman, 2004) that was designed for in situ X-ray diffraction (XRD) measurement. For comparison, dispersed clay systems were studied using standard batch solutions subjected to varying degrees of agitation. The combination of time-dependent in situ XRD measurements with gravimetric measurements and calculated diffraction patterns using the CALCMIX software (Plancon and Drits, 1999) allowed to successful quantification of the dynamics of water uptake and storage. This analytical procedure combined with published water vapour adsorption data enabled determination of the abundance of structured water layers, ...
We describe a model of damage in rf cavities and show how this damage can limit cavity operation. We first present a review of mechanisms that may or may not affect the ultimate fields that can be obtained in rf cavities, assuming that mechanical stress explains the triggers of rf breakdown events. We present a method of quantifying the surface damage caused by breakdown events in terms of the spectrum of field enhancement factors, Beta, for asperities on the surface. We then model an equilibrium that can develop between damage and conditioning effects, and show how this equilibrium can determine cavity performance and show experimental evidence for this mechanism. We define three functions that quantify damage, and explain how the parameters that determine this performance can be factored out and measured. We then show how this model can quantitatively explain the dependence of cavity performance on material, frequency, ...
We report on the spectral cross-calibration results of the Konus-Wind, the Suzaku/WAM, and the Swift/BAT instruments using simultaneously observed gamma-ray bursts (GRBs). This is the first attempt to use simultaneously observed GRBs as a spectral calibration source to understand systematic problems among the instruments. Based on these joint spectral fits, we find that 1) although a constant factor (a normalization factor) agrees within 20% among the instruments, the BAT constant factor shows a systematically smaller value by 10-20% compared to that of Konus-Wind, 2) there is a systematic trend that the low-energy photon index becomes steeper by 0.1-0.2 and Epeak becomes systematically higher by 10-20% when including the BAT data in the joint fits, and 3) the high-energy photon index agrees within 0.2 among the instruments. Our results show that cross-calibration based on joint spectral analysis is an important step to ...
Attacks by herbivorous insects reduce biomass production in willow plantations. The long-term goal of our research is to develop sustainable plant protection against these insect pests. Two lines of research are pursued. The first concentrates on identifying factors involved in the regulation of leaf-eating beetles. These insects vary in density among plantations, sometimes reaching outbreak levels resulting in complete defoliation. Mortality factors of eggs and larvae in plantations with low and high beetle densities have been investigated. The importance of plant resistance has also been investigated. The second line of research considers the mechanisms behind an earlier demonstrated resistance in certain willow clones against a gall midge. By using molecular techniques we have searched for markers of resistance. Promising results have been found concerning so called PR proteins; in particular chitinase seems to be present in high activities ...
Pyrolysis of Greek fir wood samples in a fluidized bed reactor was studied. The experimental conditions selected control the yield of gaseous, liquid and solid products. The factors examined were: pyrolysis temperature, mean particle size, pressure, residence time of volatiles, lignin content of biomass and moisture content. The experiments were performed on the basis of a 12-run Plackett-Burman fractional factorial design. Statistical analysis of the data showed that the pyrolysis temperature is the main factoraffecting the distribution of the yields of liquids, their phenolic fraction and gases in the range of experimental conditions tested. Empirical expressions were obtained from linear regression giving the yields of liquids, phenols and gases in terms of temperature. The maximum predicted yields were 56 and 12 wt.% on a moisture-free basis at 520 C and 545 C for liquids and phenols, respectively. The yield of gases ...
The deactivation rate of a resid hydrotreating catalyst is determined by a complex set of factors involving both chemical and physical changes in the catalyst structure. The various chemical changes that are associated with resid conversion involve thermal and catalytic steps of relatively large molecular weight species with the overall rates significantly affected by mass transfer limitations. The deposition of coke and the variation in the effective promoter level by the accumulation of metals deposited from the resid are the principal factors governing deactivation. The relative importance of mass transfer restrictions on activity and catalyst deactivation can be observed in studies where the average pore diameter of the catalyst has been varied. Several models have been proposed to characterize the deactivation of resid hydroprocessing catalysts. In this paper, the authors discuss some accelerated aging tests with a ...
To evaluate the predictive factors for treatment response and prognostic factorsaffecting survival outcomes after concurrent chemoradiotherapy (CCRT) for patients with anal squamous cell carcinoma. Medical records of forty two patients with histologically confirmed analsquamous cell carcinoma, who had complete CCRT between 1993 and 2008, were reviewed retrospectively. Median age was 61.5 years (39-89 years), and median radiotherapy (RT) dose was 50.4 Gy (30.0-64.0 Gy). A total of 36 patients had equal to or less than T2 stage (85.7%). Fourteen patients (33.3%) showed regional nodal metastasis, 36 patients (85.7%) were treated with 5-fluorouracil (5-FU) plus mitomycin, and the remaining patients were treated by 5-FU plus cisplatinum. The median follow--up time was 62 months (2-202 months).The 5-year overall survival, locoregional relapse-free survival, disease-free survival, and colostomy-free survival rates were 86.0%, ...
When exposure-calibrated ionization chambers are used to calibrate megavoltage X-ray and electron beam therapy machines, the calibration factor can be divided into a chamber-dependent and a chamber-independent component. Until recently, only the chamber-independent part, which has been derived theoretically, has been used; the chamber-dependent component has been ignored. Recent experimental and theoretical considerations, however, have indicated that the dependent component must be taken into account and can affect the calibration by as much as 4%. The calibration can change due to (i) the thickness of the chamber wall, (ii) the chamber wall composition, i.e. whether the chamber is constructed of air-equivalent material, or tissue- or water-equivalent material, and (iii) the size of the chamber changing the displacement factor. Theoretical and experimental evidence indicates that the third factor ...
A preliminary investigation was conducted on ion specific membranes. This investigation concentrated on testing candidate organic compounds for transporting cesium ions through a membrane composed of the organic compound supported on a substrate. Solid PVC membranes were initially tried, but were found to be too slow. Thereafter, only liquid membranes were tested. These were faster and cesium concentration factors up to 2.96 were achieved in a single membrane cell. A cell with two membranes achieved a cesium concentration factor of 4.19. Cesium precipitation with sodium tetraphenyl borate in high sodium concentrations was explored. No interference from sodium was found until the sodium nitrite concentration reached 4.5 moles. Concurrently, cesium concentrations as high as 5.4 g/L were precipitated. Potassium tetraphenyl borate is being investigated for use in exchange columns for the removal of cesium from solutions. Initial investigations show ...
A preliminary investigation was conducted on ion specific membranes. This investigation concentrated on testing candidate organic compounds for transporting cesium ions through a membrane composed of the organic compound supported on a substrate. Solid PVC membranes were initially tried, but were found to be too slow. Thereafter, only liquid membranes were tested. These were faster and cesium concentration factors up to 2.96 were achieved in a single membrane cell. A cell with two membranes achieved a cesium concentration factor of 4.19. Cesium precipitation with sodium tetraphenyl borate in high sodium concentrations was explored. No interference from sodium was found until the sodium nitrite concentration reached 4.5 moles. Concurrently, cesium concentrations as high as 5.4 g/L were precipitated. Potassium tetraphenyl borate is being investigated for use in exchange columns for the removal of cesium from solutions. Initial investigations show ...
The penetrance of Leber's hereditary optic neuropathy (LHON) in families with primary mitochondrial DNA (mtDNA) mutations is very complex. Matrilineal and nuclear genetic background, as well as environmental factors, have been reported to be involved in different affected pedigrees. Here we describe two large Chinese families that show a striking difference in the penetrance of LHON, in which 53.3% and 15.0% of members were affected (P < 0.02), respectively. Analysis of the complete mtDNA genome of the two families revealed the presence of the primary mutation G11778A and several other variants suggesting the same haplogroup status G2a. The family with higher penetrance contained a previously described secondary mutation G13708A, which presents a polymorphism in normal Chinese samples and does not affect in vivo mitochondrial oxidative metabolism as described in a previous study. ...
The penetrance of Leber's hereditary optic neuropathy (LHON) in families with primary mitochondrial DNA (mtDNA) mutations is very complex. Matrilineal and nuclear genetic background, as well as environmental factors, have been reported to be involved in different affected pedigrees. Here we describe two large Chinese families that show a striking difference in the penetrance of LHON, in which 53.3% and 15.0% of members were affected (P < 0.02), respectively. Analysis of the complete mtDNA genome of the two families revealed the presence of the primary mutation G11778A and several other variants suggesting the same haplogroup status G2a. The family with higher penetrance contained a previously described secondary mutation G13708A, which presents a polymorphism in normal Chinese samples and does not affect in vivo mitochondrial oxidative metabolism as described in a previous study. Evolutionary ...
Quantitative ecological risk assessment (ERA) is a means whereby the risk posed by a toxicant in any system can be evaluated by comparing the distribution of its measured or modelled concentrations (water quality data (WQD)) with available information on the range of concentrations that are known to adversely affect biota within that, or similar, habitats (dose-response data (DRD)). Initially, the WQD are compared with regulatory criteria (e.g. ANZECC and ARMCANZ, 2000). If they fail this test, then, on the assumption that both data sets comprise subsets of the entire range of concentrations, probability density functions are derived assuming a standard distribution form a typically log-normal. In this paper, AQUARISK has been used to estimate the risk posed by copper in effluent from the Rum Jungle mine site, pre- and post-remediation, and the proportion of taxa likely to be affected in the East Branch (EB) of the Finniss River downstream of ...
In previous research, we found that sodium-dependent high-affinity choline uptake in the hippocampus and frontal cortex of the rat was lowered after acute (45 min) exposure to low-level 2450-MHz pulsed microwaves (power density 1 mW/cm2; average whole body specific absorption rate, 0.6 W/kg; 2 mu sec pulses, 500 pps). In the present experiment, we investigated developments of tolerance and classical conditioning to these effects of microwaves. Rats were exposed to microwaves in cylindrical waveguides in 10 daily sessions (45 min per session). In an 11th session, we subjected the rats to either microwave (study of tolerance) or sham exposure (study of conditioned effect) for 45 min, and immediately measured choline uptake in the hippocampus and frontal cortex. We found that tolerance, a decrease in response to microwaves, developed to the effect of microwaves on choline uptake in the hippocampus, but not in the frontal ...
Radioimmunotherapy (RIT) is a new treatment option for patients with non-Hodgkin lymphoma (NHL). Response to RIT currently remains difficult to predict using conventional prognostic factors and could be refined using functional imaging. The goal of this work is to evaluate the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting response to Yttrium 90-labeled monoclonal antibodies for patients with NHL. Thirty-five patients with NHL who had undergone 18F-FDG PET prior to RIT with either 90Y-ibritumomab tiuxetan (group A; n=17) or 90Y-epratuzumab tetraxetan (group B; n=18) were included in this retrospective study. Four functional criteria were determined for each tumour lesion in a given patient: maximum and mean standard uptake values (SUVmax and SUVmean), functional lesion volume (LVol) and total lesion glycolysis (TLG, product of the volume and the SUVmean). For each patient, we determined highest SUVmax and ...
The rapid growth in the use of in vitro methods for nanoparticle toxicity assessment has proceeded with limited consideration of the unique kinetics of these materials in solution. Particles in general and nanoparticles specifically, diffuse, settle and agglomerate in cell culture media as a function of several systemic and particle factors: media density and viscosity, particle size, shape and density. Cellular dose then is also a function of these factors as they determine the rate of transport of nanoparticles to cells in culture. Here we develop and apply the principles of particokinetics and dosimetry in vitro and outline an approach for simulation of nanoparticle particokinetics in cell culture systems. We illustrate that where equal mass concentrations (?g/ml) imply equal doses for dissimilar materials, the corresponding particle number or surface area concentration doses differ by orders of magnitude. When rates of diffusional and ...
Although the public generally hold positive attitudes towards wind energy, proposals for the construction of new wind farms are often met with strong resistance. In New Zealand, where the government has recently introduced ambitious policy targets for renewable energy generation, negative perceptions of wind farms are increasingly evident and have the potential to prevent the achievement of these targets. This research sets out to examine what influences social resistance to wind farms in New Zealand. Drawing from public submissions on three wind farm proposals, a framework developed by Devine-Wright [Devine-Wright, P., 2005a. Beyond NIMBYism: towards an integrated Framework for Understanding Public Perceptions of Wind Energy. Wind Energy 8, 125-139.] was used as the basis for identification of factorsaffecting public perceptions of wind farms. The research found firstly that there was no apparent relationship between the proximity of ...
Although the public generally hold positive attitudes towards wind energy, proposals for the construction of new wind farms are often met with strong resistance. In New Zealand, where the government has recently introduced ambitious policy targets for renewable energy generation, negative perceptions of wind farms are increasingly evident and have the potential to prevent the achievement of these targets. This research sets out to examine what influences social resistance to wind farms in New Zealand. Drawing from public submissions on three wind farm proposals, a framework developed by Devine-Wright [Devine-Wright, P., 2005a. Beyond NIMBYism: towards an integrated Framework for Understanding Public Perceptions of Wind Energy. Wind Energy 8, 125-139.] was used as the basis for identification of factorsaffecting public perceptions of wind farms. The research found firstly that there was no apparent relationship between the proximity of ...
Background: Recent studies have developed a murine model of IgE-mediated food allergy based on oral coadministration of antigen and cholera toxin (CT) to establish a maximal response for studying immunopathogenic mechanisms and immunotherapeutic strategies. However, for studying subtle immunomodulating factors or factors effective during response initiation, this maximal response-based model is less suitable due to a lack of sensitivity. Therefore, in attempts to identify essential parameters to fine-tune the immune response towards a submaximal level, potentially more sensitive, we were interested in characterizing the individual effects of the parameters in the CT-based model: CT dose, antigen type and dose, and number of immunizations. Methods: BALB/c mice were orally sensitized weekly for 3 or 7 weeks with graded doses of CT and various food antigens (soy-trypsin inhibitor, ovalbumin or ovomucoid). Antigen-specific lgG1, IgG2a, IgA and IgE ...
Water repellency en the microstructure super-hydrophobic cured surface is important for research and industrial purposes. This microstructure film can be cured on polyethylene terephthalate PET surface by electron beam (EB) at different irradiation doses 10-100 kGy. The microstructure formulation composed from hydrophobic acrylate oligomer (EB 244) and monomer (SR 440). The irradiation induced cross linking of the prepared microstructure was proved by FTIR spectroscopy and the adhesion force by abrasion test. Some factorsaffecting the adhesion force of the prepared microstructure film such as oligomer/monomer composition ratio and the thickness of the microstructure cured film were studied. The contact angles (8) were measured on cured surfaces before and after adding the super hydrophobic nanoparticles (Zonyl 9361). The super-hydrophobic cured surface showed the self-cleaning property. The volume of water droplet affected ...
Critical power at boiling transition is an important factor in a boiling water reactor (BWR) fuel bundle design. Boiling transition under high quality accounts for dryout as the result of the complete disappearance of film flow on a fuel rod. This liquid film vanishing process can be calculated by the liquid film model, which takes into account the evaporation due to heat from the rod surface, liquid film entrainment by steam flow, and liquid droplet deposition. It is known that spacers affect liquid film entrainment and liquid droplet deposition, so the detailed study of spacer effects on hydrodynamic characteristics is necessary for critical power prediction based on the film flow model. Many studies have been conducted to examine spacer effects on liquid film flow. However, most of them are restricted to simple test sections such as a rectangular conduit. There are a few reports on fuel bundle geometry; however the bundle studied was only a ...
Neutrino emission drives neutron star cooling for the first several hundreds of years after its birth. Given the low energy ($\\sim$ keV) nature of this process, one expects very few nonstandard particle physics contributions which could affect this rate. Requiring that any new physics contributions involve light degrees of freedom, one of the likely candidates which can affect the cooling process would be a nonzero magnetic moment for the neutrino. To illustrate, we compute the emission rate for neutrino pair bremsstrahlung in neutron-neutron scattering through photon-neutrino magnetic moment coupling. We also present analogous differential rates for neutrino scattering off nucleons and electrons that determine neutrino opacities in supernovae. Employing current upper bounds from collider experiments on the tau magnetic moment, we find that the neutrino emission rate can exceed the rate through neutral current electroweak interaction by a ...
High surface ozone concentration is increasingly being recognized as a factor that negatively affects crop yields in Asia. However, little progress has been made in developing ozone-tolerant genotypes of rice-Asias major staple crop. This study aimed to identify possible tolerance mechanisms by characterizing two quantitative trait loci (QTLs) that were previously shown to influence visible leaf symptoms under ozone exposure (120 nl l-1, 7 h d-1, 13 d). Two chromosome segment substitution lines (SL15 and SL41) that carried introgressions of the QTLs OzT3 and OzT9, respectively, were exposed to ozone at 120 nl l-1 along with their parent Nipponbare. In accordance with the expected QTL effect, SL15 showed stronger visible symptoms of ozone damage than Nipponbare, whereas SL41 had fewer sympt...
This technology development plan is designed to provide a clear understanding of the research and development direction necessary for the qualification of nuclear grade graphite for use within the Next Generation Nuclear Plant (NGNP) reactor. The NGNP will be a helium gas cooled Very High Temperature Reactor (VHTR) with a large graphite core. Graphite physically contains the fuel and comprises the majority of the core volume. Considerable effort will be required to ensure that the graphite performance is not compromised during operation. Based upon the perceived requirements the major data needs are outlined and justified from the perspective of reactor design, reatcor performance, or the reactor safety case. The path forward for technology development can then be easily determined for each data need. How the data will be obtained and the inter-relationships between the experimental and modeling activities will define the technology development for graphite R&D. Finally, the ...
This report describes an investigation of the factorsaffecting disintegration time in the mouth (DTM) of rapidly disintegrating tablets. The relation between DTM and stationary time of upper punch displacement (STP) was examined using a tableting process analyzer (TabAll). Results indicated that the bulk density of mixed excipient powder used for tablet preparation affects both DTM and STP. As the value of bulk density increased, STP became longer and DTM shorter. The results of a combination of granules and powder with or without a drug showed liner relation between apparent volume (reciprocal of bulk density) and DTM (r(2)=0.7332). For a DTM less than 60 s, a formulation with a bulk density greater 0.5 g/mL should be chosen with a compression force of 5 kN. The hardness of tablets could be greater than 3 kg if at least one high-compressibility excipient was used in the formulation. PMID:18804156
This study compares the spatial characteristics of industrial R&D networks to those of public research R&D networks (i.e. universities and research organisations). The objective is to measure the impact of geographical separation effects on the constitution of cross-region R&D collaborations for both types of collaboration. We use data on joint research projects funded by the 5th European Framework Programme (FP) to proxy cross-region collaborative activities. The study area is composed of 255 NUTS-2 regions that cover the EU-25 member states (excluding Malta and Cyprus) as well as Norway and Switzerland. We adopt spatial interaction models to analyse how the variation of cross-region industry and public research networks is affected by geography. The results of the spatial analysis provide evidence that geographical factors significantly affect patterns of industrial R&D collaboration, while in the public ...
This report describes the result of work completed during February, 1982 to October 1983. The aim of the work was to develop a low NO(x) emission range top burner. Discussed is the development of a flame insert modification to an existing burner which reduces NO(x) emission by 45 percent and NO2 emission by 25 percent. This relatively simple burner add-on device appears to be an economically viable low NO(x) burner. It was developed in cooperation with a major range manufacturer. The levels of NO(x) (NO2) reduction achieved should significantly reduce the impact of a gas range to indoor quality. The report also discusses the results of a literature search that preceeded the burner development. The search helped to direct the burner development by reviewing the state-of-the-art of low NO(x) burner design and covered factors which affect the indoor impact of range emissions such as air infiltration and ventilation trends, air quality standards, ...
This document describes the contents of a digital climatological data set that may be used by raster or vector geographic information systems (GISs). The primary focus of the data set is the quantification of the occurrence of synoptic storms and other climatological factors that affect coastlines. However, recent demands for new and/or improved climatologies of storm events as well as an increase in the availability of source data have made it useful to extend the domain of most of the data variables to that of regional and/or global coverage. The expansion of the data makes the data set applicable in several areas of climatic research. The data set contains eight data groups. Spatial coverage of data varies by data group. All data groups except one are referred to 1{degree} {times} 1{degree} or 5{degree} {times} 5{degree} grid cells of latitude and longitude. (Data group (3) is referenced by state.) 19 refs., 12 figs., 26 tabs.
We recently found that injection of 2 mCi of yttrium 90 (90Y; approximately 23,000 rads) into normal canine knees stimulated glycosaminoglycan (GAG) synthesis by femoral condylar cartilage. The present investigation was conducted to determine whether radiation affects cartilage metabolism directly. Rates of GAG synthesis and degradation in normal canine articular cartilage were studied following irradiation. Cultured synovium from the same knees was treated similarly, to determine the effects of irradiation on hyaluronic acid synthesis. Twenty-four hours after exposure to 1,000 rads, 10,000 rads, or 50,000 rads, 35S-GAG synthesis by the cartilage was 93%, 69%, and 37%, respectively, of that in control, nonirradiated cartilage. The effect was not rapidly reversible: 120 hours after exposure to 50,000 rads, GAG synthesis remained at only 28% of the control level. Autoradiography showed marked suppression of 35S uptake by chondrocytes after ...
This paper describes the results of a model intercomparision exercise for predicting tritium transport through foodchains. Modellers were asked to assume that farmland was exposed for one hour to an average concentration in air of 10{sup 4} MBq tritium m{sup -3}. They were given the initial soil moisture content and 30 days of hourly averaged historical weather and asked to predict HTO and OBT concentrations in foods at selected times up to 30 days later when crops were assumed to be harvested. Two fumigations were postulated, one at 10.00 h (i.e., in day-light), and the other at 24.00 h (i.e., in darkness).Predicted environmental media concentrations after the daytime exposure agreed within an order of magnitude in most cases. Important sources of differences were variations in choices of numerical values for transport parameters. The different depths of soil layers used in the models appeared to make important contributions to differences in predictions for the given scenario. ...
The importance of indigenous soil Mn level on plant Mn uptake from metal salt or sewage sludge amended soils was investigated. Twelve soil materials, six surface and six subsurface, were amended with either varying rates of a composite of Cd, Cu, Ni, and Zn sulfate salts, equivalent to the total of these metals present in a digested sewage sludge (Washington, DC) at rates of 0 to 896 dry metric tons/ha or with the sludge itself, at 224 dry metric tons/ha. Corn (Zea mays L.) was grown in the greenhouse for 30 days, 1 year after amendment application. Two pH levels of about 5.5 and 6.5 were maintained during the experiment on the metal salt amended soil materials. Plant tissue Mn levels increased with the application of Cd, Cu, Ni, and Zn (in combination) as metal salts or as sewage sludge over the range of soil materials used. The amount of increase with a given increase in applied metals was greater for the unlimed than for the limed metal salt treatments. Elevated ...
The beneficial effect of compost application to the sandy soil on dry matter production of shoots and fruits as well as its effect on l5N-uptake and nitrogen utilization percent of cucumber plant (Cucumis sativus L.) were studied under field conditions. Two types of natural compost (i.e. sugar cane bagasse (SC) and beet compost (BC)) with three levels (2, 4, 6 ton/fed) in addition to check treatment for each kind of compost (sheep manure with rate of 20 in/fed) combined with three rates of nitrogen fertilizer rates (50, 75, 100% from the recommended rate, i.e. 75 kg /fed) were used. The bagasse compost in both seasons gave a significantly higher response than the beet compost. There was a greet reduction in cucumber dry weight, N yield, Ndff%, FN yield and N utilization % of shoots and fruits as the level of compost application decreased. However, cucumber plants grown on high compost application level (6 ton/fed) were similar in their responses to plants grown on ...
Organic materials released from energy-related activities could affect human health and the environment. To better assess possible impacts, we developed a model to predict the fate of spills or discharges of pollutants into flowing or static bodies of fresh water. A computer code, Aquatic Pathways Model (APM), was written to implement the model. The computer programs use compartmental analysis to simulate aquatic ecosystems. The APM estimates the concentrations of chemicals in fish tissue, water and sediment, and is therefore useful for assessing exposure to humans through aquatic pathways. The APM will consider any aquatic pathway for which the user has transport data. Additionally, APM will estimate transport rates from physical and chemical properties of chemicals between several key compartments. The major pathways considered are biodegradation, fish and sediment uptake, photolysis, and evaporation. The model has been implemented with ...
Chinese brake fern (Pteris vittata L.), an arsenic (As) hyperaccumulator, has shown the potential to remediate As-contaminated soils. This study investigated the effects of soil amendments on the leachability of As from soils and As uptake by Chinese brake fern. The ferns were grown for 12 weeks in a chromated-copper-arsenate (CCA) contaminated soil or in As spiked contaminated (ASC) soil. Soils were treated with phosphate rock, municipal solid waste, or biosolid compost. Phosphate amendments significantly enhanced plant As uptake from the two tested soils with frond As concentrations increasing up to 265% relative to the control. After 12 weeks, plants grown in phosphate-amended soil removed >8% of soil As. Replacement of As by P from the soil binding sites was responsible for the enhanced mobility of As and subsequent increased plant uptake. Compost additions facilitated As uptake from the CCA ...
The purpose of this investigation was to simulate a machining front from an abrasive waterjet and its movements in a ceramic material. Wear factorsaffecting the abrasive waterjet nozzle were also to be established. Therefore, a low inclination angle (9[degree]) was used between the nozzle and test sample, simulating a moving machine front. A standard nozzle with an inner diameter of 0.76 mm was used in the test, and it was placed close to the samples. The outer diameter of the abrasive nozzle was 9.5 mm. The high wear rate from abrasive waterjets makes it possible to machine hard ceramics-including dense alumina, titanium boride, silicon nitride, and composites-at high machining speeds.
There are many factorsaffecting diffusion bonding in order to obtain high quality joining. Therefore, in the beginning, we constructed diffusion bonding model based on void growth mechanism to predict bonding pressures and times. In addition, in order to compare theoretical values with experimental values, diffusion bonding tests were carried out by using commercial AZ31 magnesium alloy sheets with different grain sizes, 16 and 130 {mu}m. The present AZ31 alloys were successfully diffusion bonded at several conditions, and the bonding strength was more than 0.8 of each parent materials. The experimental bonding conditions in high quality joining, times and pressures, were good agreed with prediction analysis. (orig.)
Water?rock interaction is one of the prime factorsaffecting the fluoride contents of surface and groundwater. If fluoride concentration of drinking water has been neglected, excess fluoride can cause serious dental and medical problems on human health, which is well known at Golcuk-Isparta region. In the research area, Egirdir lake, Golcuk lake and surrounding springs have been utilized as drinking water sources. Golcuk lake water and surrounding groundwaters have high fluoride content (1.4?4.6?mg/l), which is above the WHO standards. Fluoride is predominantly supplied by dissolution of fluoride within the fluormicas of volcanics during the circulation of water. Fluoride concentrations of waters have shown variations for dry and rainy seasons depending on the degree of interaction between...
The factorsaffecting the rate of silica leaching in alkaline aqueous media from surface silanized, nanoporous, amorphous, silica gels and from silanized silica gels that have been modified with polyamines to form the previously reported silica polyamine composites (SPCs), BP-1 and BP-2 have been investigated. Silanization with alkyl trichlorosilanes slows the rate of silica leaching relative to the unmodified silica gels. The use of bulkier aryl silanes somewhat decreases the silica leaching under the same conditions. Interestingly, after modification of the silanized silica with poly(allylamine) (PAA) to make BP-1, the leaching increases, but subsequent modification of the SPC with chloroacetic acid to make BP-2, quenches this increase. A mechanism explaining these results is discussed. ...
In the world of pipeline maintenance, there are pigs and there are intelligent pigs. Intelligent pigs, when launched into a pipeline, carry instrumentation onboard which enables them to gather and record information about problems such as denting, corrosion, and cracking. More basic pigs, on the other hand, look after the routine internal maintenance chores such as cleaning and swabbing, or else perform operational duties such as batching different types of product along the line. The harsh environment in which pigs often operate is described. Aside from the mechanical shocks they undergo when passing welds, bends, and other fittings, they may have to contend with hostile conditions such as hydrogen sulfide environments. High pressure is another factor to consider. In crude oil lines, significant paraffin deposits also can cause problems if they affect the sensors ability to maintain good contact with the pipe wall. In spite of these ...
Abstract Lyme disease is a perfect model of the complex relationship between host, vector, and the vector-borne bacteria. Both dogs and horses in Romania are exposed to infection. The aim of the present study was to assess the seroreactivity against Borrelia burgdorferi sensu lato in dogs and horses from different regions of Romania. 276 samples from dogs and 260 samples from horses located in different regions of Romania were analyzed by ELISA and IFA, respectively. The effect of several factors potentially affecting seroreactivity (location, age, gender, occupation, and vector exposition risk) was evaluated using Fisher's exact test (R 2.12.0). The overall prevalence of anti-Borrelia antibodies was 6.52% (18/276) in dogs, with a significantly higher positivity (46.15%, 6/13, p=0.0005) re...
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Abstract The overstory of the jarrah forest is dominated by Jarrah (Eucalyptus marginata) with a smaller proportion of Marri (Corymbia calophylla). There are also several smaller tree species in the areas where Alcoa mines. Alcoa's restoration aims to restore all these species at densities similar to the unmined forest. This paper describes the establishment, survival, and growth of these trees with particular focus on Jarrah. Factorsaffecting the growth and form of Jarrah are also discussed. Establishment of Jarrah from seed in restored sites is variable (mean 10%), and once established, survival is high over two summer droughts (96%) and still high (mean 83%) after about a decade regardless of the presence of the Jarrah dieback disease Phytophthora cinnamomi. High establishment densitie...
A large body of evidence indicates clear relationships between number and space processing in healthy and brain-damaged adults, as well as in children. The present paper addressed this issue regarding atypical math development. Adults with a diagnosis of dyscalculia (DYS) during childhood were compared to adults with average or high abilities in mathematics across two bisection tasks. Participants were presented with Arabic number triplets and had to judge either the number magnitude or the spatial location of the middle number relative to the two outer numbers. For the numerical judgment, adults with DYS were slower than both groups of control peers. They were also more strongly affected by the factors related to number magnitude such as the range of the triplets or the distance between t...
Environmental radon monitoring activities at the DOE Fernald Environmental Management Project (FEMP) have been conducted extensively since the early 1980`s. Monitoring has been conducted at ambient concentration levels (< 1 pCi/L Rn-222), inside buildings, and at significantly elevated levels (hundreds of thousands pCi/L Rn-222) within the K-65 silo that store concentrated radium bearing wastes. The purpose of this paper/presentation is to present and discuss some of the difficulties encountered/solutions (e.g. reliability, detection limits, affects of environmental factors, data transfer, etc.) that have been discovered while taking measurements using both alpha track-etch passive integrating detectors and alpha scintillation real-time detectors. A short summary and conclusion section is provided following each topic presented.
Abstract Tumor necrosis factor (TNF)- is a pro-inflammatory cytokine associated with psoriasis pathogenesis. Anti-TNF- therapies are effective in psoriasis. A significant weight gain has been reported in patients treated with anti-TNF- agents. The aim of the present study was to evaluate the body composition changes in psoriatic patients receiving anti-TNF- therapies according with disease phenotype. Forty patients affected with psoriasis were followed up for 24 weeks and divided into two groups: psoriasis vulgaris (PsO) and psoriatic arthritis (PsA). Anthropometric, blood biochemical, body composition parameters, resting metabolic rate, and disease activity indexes were measured at baseline and at week 24. After 24 weeks of anti-TNF- administration, the disease activity indexes and concen...
Improved radionuclide generator include a substantially insoluble salt of a radioactive parent which may be directly packed in column for subsequent elution of the daughter radionuclide. An improved 188Re generator was prepared by reacting a radioactive tungsten (188W) as parent radionuclide incorporated with aluminum chloride to obtain an insoluble radioactive aluminum tungstate matrix. The investigated matrix was characterized on the basis of the chemical composition, IR, thermal analysis and mechanical stabilities. The factorsaffecting the elution performance were studied such as influence of pH, molar ratio and drying temperature. From the obtained data, the molar ratio W:Al was 1.5:1 at pH?=?4, the matrix dried at 105??C for 2 h. Chromatographic and multichannel analysis has been cur...
A brief discussion on the effects of moisture on the quality of metallurgical coke was presented. Factorsaffecting the moisture content of coke were discussed. The adsorption of moisture by coke at 20/sup 0/C and 120-130/sup 0/C and the desorption of moisture from coke at 200/sup 0/C were investigated with respect to dynamics. It was concluded that the moisture content of coke should not be used as a rejection index, but should be used for computations by the user. Also, it was determined that work should continue to achieve a coke moisture range of 4-6%. The desorption of moisture from coke is an order of magnitude greater at 200/sup 0/C than at 20/sup 0/C, and increases with temperature.
A novel composite charged mosaic membrane (CCMM) was prepared via interfacial polymerization (IP) of polyamine [poly(epichlorohydrin amine)] and trimesoyl chloride (TMC) on the polyethersulfone (PES) support. Fourier transform infrared spectroscopy (FT-IR), environmental scanning electron microscopy (ESEM), atomic force microscopy (AFM) and water contact angle analysis were applied to characterize the resulted CCMM. The FT-IR spectrum indicates that TMC reacts sufficiently with polyamine. ESEM and AFM pictures show that the IP process produces a dense selective layer on the support membrane. The water contact angle of the CCMM is smaller than that of the substrate membrane because of the cross-linked hydrophilic polyamine network. Several factorsaffecting the IP reaction and the performan...
We present an innovative approach to estimating residential irrigation water demand for a large metropolitan area using GIS data, weather station data, and a water budget modeling approach commonly used by plant scientists and landscape management professionals. An important question addressed by our study is how a growing urban forest affects the overall irrigation water demand of a semiarid metropolitan area. To estimate the amount of water required by residential landscaping, we consider water demand to be a function of the areal extent of residential landscaping (i.e. tree/shrub or turf grass), the water-loss rate for different landscaping types, the efficiency with which the landscape is irrigated, and local climatic factors (i.e. reference evapotranspiration and precipitation). We es...
Objectives Vietnamese patients? views on healthcare are changing as surgical interventions become more commonplace, but their views on perioperative care have remained largely unstudied during this period of rapid change. This study assesses Vietnamese patients? impression of anesthesia safety and postoperative pain in relation to clinical outcomes with the aim of improving patient-centered perioperative care. Methods The study cohort consisted of 180 hospitalized patients who were followed for 24?h following abdominal surgery. The assessments of these patients on the use of anesthesia and postoperative pain were measured by means of a 5-point Likert scale survey. Perioperative events were recorded on standardized forms by medical staff. The relationship between relevant factorsaffecting ...
A central composite design was employed to optimize the extraction of pectin with citric acid. The independent variables were citric acid concentration (0.086-2.91% w/v) and extraction time (17-102min). The combined effect of these variables on the degree of esterification was investigated. Results have shown that the generated regression models adequately explained the data variation and significantly represented the actual relationship between the independent variables and the responses. Besides that, the citric acid concentration was the most important factor to affect the degree of esterification, as it exerted a significant influence on the dependent variable. Lower citric acid concentration increased the pectin degree of esterification. The surface response showed the relationships b...
Some factorsaffecting the accuracy of magnitude calibration of palaeoearthquakes are discussed. The general problem is illustrated by two case studies. First, the 2003 strong earthquake in the Altai region (Russia-Mongolia border), which has generated co-seismic surface faulting is considered. An analysis is conducted to determine how accurately its magnitude could be defined after 2000 years based on surface faulting parameters, retrieved when future palaeoearthquake studies are launched. This example demonstrates that accurate evaluation of magnitude is possible if specific regional seismotectonic features are taken into account and surface faulting parameters are measured over a dense grid. Next, the Muya earthquake that occurred in the Baikal seismic region in 1957 is studied with res...
In this study, Nylon 66/Polyester (Ny 66/PET) hybrid cord design and production was investigated to obtain new cord with better performance than conventional cord. The factorsaffecting cord properties and cord production process were examined. Taguchi design of experiment method was implemented in order to minimize the required number of experiments. Different sets of 4 reference cords conventionally used in tyre industry were prepared and resorcinol-formaldehyde-latex (RFL) treated in order to make a comparison of performance. Mechanical and thermal properties of hybrid cords were measured and compared with the values of reference cords. It was found that the twist level of high modulus PET component in the hybrid cords should be the same or above of the nylon in order to obtain maximum ...
ObjectivesTo determine the reaction rate of slag during curing and factorsaffecting reactivity.~%~~%~To measure the rates of chloride ingress into concrete and the extent of chloride binding.~%~~%~To determine conditions for pitting corrosion and the nature of corrosion products.~%~~%~To characterise the reactions in slag-calcium alumina cement hydration and the nature of the products.~%~DescriptionBlast-furnace slag has latent hydraulic properties, giving considerable potential for commercial use in addition to its widespread use as a partial replacement for Portland cement, notably in alkali-activated slag (AAS) and slag-calcium alumina cement (CAC) concretes. Use of AAS concretes is already well-established in China and the former USSR, but their further application is hindered by lack of research into setting, hydration and durability, Slag/CAC blends are new materials whose chemistr ...
This paper aims to provide a comprehensive review of the various models or simulations for predicting drug release from bulk-degrading systems. A brief description of bulk degradation processes and factorsaffecting the degradation rate, and consequently the release kinetics, is presented first. Next, several important classical models, often used as the basis for subsequent model development, are discussed. Both mathematical models and Monte-Carlo based simulations have been developed for controlled release from bulk-degrading systems. The mathematical models can be further subdivided into two categories. First, the diffusion-based models whose transport mechanism is mainly governed by diffusion, but with degradation-dependent diffusion coefficients. These are generally simpler and easier...
Since the fluoroscopic image during nasoenteral tube placements is used for guidance and not for diagnosis, a lower contrast image with increased quantum mottle can be easily tolerated. The three methods to reduce the radiation dose rate investigated consisted of removing camera from the image intensifier output phosphor, and setting the fluoroscopic mA to the minimum value so that the kVp could be maximized. Fluoroscopic frozen video frames of a clinical tube insertion comparing the images with and without the dose-saving techniques are presented. Measurements of the radiation dose rates using a Plexiglas phantom show that the dose for patient and staff during fluoroscopic-guided nasoenteral tube placements can be reduced by over a factor of 10 without significantly adversely affecting the actual placement procedure. (author).
To quantify the opportunities for natural gas and identify technological advances needed to capture such opportunities, the mineral-wool industry was analyzed with respect to the principal companies, their capabilities, and markets. The mineral-wool industry is stable with a slightly declining market. Of its market segments, only commercial acoustic insulation (which is currently dominant) is likely to be affected by growth in the next ten years. The principal process is based on treatment of blast-furnace slags in a cupola furnace using coke as the fuel and reducing agent. Expanded use of gas, as a substitute for coke, would eliminate environmental problems and expand the latitude of suitable raw materials. The study provides insights into the mineral-wool industry and identifies factors that may constitute bases for future usage of natural gas.
AISI 316L stainless steel was welded by the electron beam (EB) and laser techniques. Microstructural characteristics, hardness profile, creep rupture properties and creep damage of the welds were investigated. Fully austenitic microstructure was obtained in the two welds. The solidification structure of the welds consisted of the cellular and equiaxed dendrites. The creep rupture lives of the two welds were almost the same, and they were reduced by a factor of about two compared to the base metal. Moreover, the rupture elongation of the welds was lower than that of the base metal. Creep damage was observed in the ``parting`` region of the welds and in the heat-affected zone (HAZ), respectively. Final creep fracture occurred in the ``parting`` region of the welds. (orig.).
AISI 316L stainless steel was welded by the electron beam (EB) and laser techniques. Microstructural characteristics, hardness profile, creep rupture properties and creep damage of the welds were investigated. Fully austenitic microstructure was obtained in the two welds. The solidification structure of the welds consisted of the cellular and equiaxed dendrites. The creep rupture lives of the two welds were almost the same, and they were reduced by a factor of about two compared to the base metal. Moreover, the rupture elongation of the welds was lower than that of the base metal. Creep damage was observed in the ''parting'' region of the welds and in the heat-affected zone (HAZ), respectively. Final creep fracture occurred in the ''parting'' region of the welds. (orig.).
Tensile and flexural properties of single-gated (SG) and double-gated (DG) injection moulded blend of polybutylene terephthalate (PBT) and polycarbonate (PC) and its composites containing 15, 20 and 30?wt.% short glass fibres were investigated. In the DG mouldings, a weldline was formed by direct impingement of two opposing melt fronts (i.e. cold weld). It was found that tensile modulus was not affected by the weldline but flexural modulus decreased in the presence of weldline. For both specimen types, modulus increased linearly with volume fraction of fibres (? f), according to the rule-of-mixtures for moduli. The weldline integrity (WIF) factor for flexural modulus decreased linearly with increasing ? f. Results showed that tensile and flexural strengths for SG mouldings increase with in...
MRI diagnosis for malignant tumors are made possible by direct comparison to the results obtained by the brain and it seems possible to differentiate malignant tumors from other benign lesions. Cystic lesions, and mycotic sinusitis sometimes resemble malignant tumors in MR Image. In the present report, we investigated the relationships between the biochemical contents of cystic lesions and NMR-parameters to clarify why some inflammatory lesions appeared similar to malignant tumors in MRI. The variation of relaxation time depends upon the amount of protein in the cystic contents and the amount of glucose affects the relaxation time. We conclude that NMR-parameters are useful for the differential diagnosis of malignant tumors, cystic lesions and mycositic sinusitis by using the multiple variation analysis.
Methods for improving the sensitivity of scintillation cells for radon concentration measurements were studied with emphasis on improving light collection efficiency. This allows the length and hence the volume of the cell to be increased. Variables studied were choice of scintillator material, its method of application and thickness, length of cell, cell material, type and configuration of reflectors, choice of photomultipliers, and factorsaffecting background. Response from various areas of the cell surface was studied with an alpha source and with radon filling. Coating the window with phosphor was found to be counter-productive. The optimum results obtained were with the inside of the cell (other than the window) covered with a thick layer of ZnS(Ag), or with a thick layer of reflective material coated with a thin layer of phosphor. With it, a 10 cm diameter plexiglass cell can be extended to at least 50 cm length without difficulty from ...
Methods for improving the sensitivity of scintillation cells for radon concentration measurements were studied with emphasis on improving light collection efficiency. This allows the length and hence the volume of the cell to be increased. Variables studied were choice of scintillator material, its method of application and thickness, length of cell, cell material, type and configuration of reflectors, choice of photomultipliers, and factorsaffecting background. Response from various areas of the cell surface was studied with an alphy source and with radon filling. Coating the window with phosphor was found to be counter-productive. The optimum results obtained were with the inside of the cell (other than the window) covered with a thick layer of ZnS(Ag), or with a thick layer of reflective material coated with a thin layer of phosphor. With it, a 10 cm diameter plexiglass cell can be extended to at least 50 cm length without difficulty from ...
Plant secondary chemistry is determined by both genetic and environmental factors, and while large intraspecific variation in secondary chemistry has been reported frequently, the levels of genetic variation of many secondary metabolites in forest trees in the context of potential resistance against pests have been rarely investigated. We examined the effect of tree genotype and environment/site on the variation in defensive secondary chemistry of lodgepole pine, Pinus contorta var. latifolia, against the fungus, Grosmannia clavigera (formerly known as Ophiostoma clavigerum), associated with the mountain pine beetle, Dendroctonus ponderosae. Terpenoids were analyzed in phloem samples from 887, 20-yr-old trees originating from 45 half-sibling families planted at two sites. Samples were coll...
The Sulige gas field and the Yulin gas field are located in the north of the Ordos Basin. Reservoir pressure in the Sulige area is subnormal, whereas reservoirs in the Yulin area have normal hydrostatic pressure. This paper provides an explanation of this difference. The characteristics of reservoir sediment and formation water chemistry in the gas reservoirs of these two areas were analyzed. The results showed that both reservoirs have good sealing ability. Data of numerical simulation showed that tectonic uplift resulted in a great reduction in formation pressure in the northern Ordos Basin during the late Cretaceous period, and the decrease was greater in the Yulin gas field than in the Sulige gas field. However, because the total hydrocarbon-generating intensity of the Sulige area (<24...
Isopropyl chloroacetate has been synthesized by esterification of chloroacetic acid and isopropanol, using lanthanum dodecyl sulfate (LDDS) as the catalyst. Various factors that affected the esterification have been investigated, such as reaction time, different water-carrying agent and the amount of catalyst. Under the condition of 1.2/1 molar ratio of isopropanol to chloroacetic acid, 1.0% catalyst (molar percent of chloroacetic acid), 2.5 h reaction time, 5 mL cyclohexane as water-carrying agent and reflux temperature, the esterification conversion of isopropyl chloroacetate reaches 98.3%. The catalytic activity of LDDS is almost equal to that of a Bronsted acid. LDDS, as one kind of water-tolerant Lewis acid, is an excellent catalyst compared to the traditional Lewis acid. (author)
A linear diffusion model serves as the basis for determination of an effective radon diffusion coefficient in concrete. The coefficient was needed to later allow quantitative prediction of radon accumulation within and behind concrete walls after application of an impervious radon barrier. A resolution of certain discrepancies noted in the literature in the use of an effective diffusion coefficient to model diffusion of a radioactive gas through a porous medium is suggested. An outline of factors expected to affect the concrete physical structure and the effective diffusion coefficient of radon through it is also presented. Finally, a field method for evaluating effective radon diffusion coefficients in concrete is proposed and results of measurements performed on a concrete foundation wall are compared with similar published values of gas diffusion coefficients in concrete. (author).
We investigated the magnet field dependence of the X-ray pulse height and the critical current of a Ti/Au bilayer TES micro-calorimeter. The pulse height was strongly affected by the magnetic field intensity applied perpendicularly to the TES surface. We found that the critical current at zero temperature, I c0, decreased by a factor of two by applying a magnet field of ?10??T. Our data are consistent with a TES sensitivity proportional to (I/I c0)?2/3, as predicted by the Ginzburg-Landau theory. This fact implies that the shape of the R?T curve of the TES is partly determined by the critical current of the superconductor. In order to make our TES microcalorimeters less sensitive to the external magnetic field, we fabricated devices equipped with on-chip magnetic shielding. One device has ...
Purpose: The DBA/2J mice have been used as an animal model for human pigmentary glaucoma. However, these mice develop various degrees of disease symptoms at different ages, making it difficult to detect pathological changes of retinal degeneration at glaucoma onset. The purpose of this study is to develop a non-invasive assay to identify individual mice that develop visual deficits. Materials and Methods: We apply two behavioral tests, a swimming test of visual discrimination and a test of optomotor response, to identify glaucomatous DBA/2J mice. We then examine whether the elevation of intraocular pressure (IOP), the common risk factor for glaucoma, affects visual performances of the DBA/2J mice. We further compare the retinal ganglion cell death, one of the signature glaucoma symptoms, i...
A full analysis is shown in this paper for the cost of kWh generated from photovoltaic station located in Kuwait. By using a 21 years weather data for Kuwait, the yearly generated energy was found by proposing the PV station capacity with known panels tilt angle. The cost of kWh generated from PV station was compared with the kWh generated from conventional units in the country. A sensitivity analysis was done to some factors, capital cost per installed PV peak watt, discount rate, and operating peak hours, which affect the cost of kWh production from both PV and conventional units. If the PV station is proposed to be installed in Kuwait, the capital cost per PV installed peak watt must be less than today`s prices. (author)
An overview of climatic factors and impact relative to river ice engineering and science is presented. An explanation of the fundamentals of climatic change is followed by a review of direct and indirect climatic influences that govern river ice breakup and related trends. Known responses of river ice to climatic change and potential future changes to ice breakup processes are described along with the probable ecological and socio-economic consequences of these changes. Changes in engineering approaches to accommodate the present ice regime and predicted changes in climatic variables that affect river ice processes and reduce the vulnerability of infrastructure and ecosystems to climatic change are examined. Future research on the links between river ice and stream ecology is suggested to identify ecological concerns that may result from changes in river ice regimes induced by climatic change. 60 refs., 3 figs.
New technologies are needed to reduce the current high rate of well abandonment. Improved sweep efficiency, reservoir conformance, and permeability modification can have a significant impact on oil recovery processes. Microorganisms can be used to selectively plug high-permeability zones to improve sweep efficiency and impart conformance control. Studies of a promising microbial system for polymer production were conducted to evaluate reservoir conditions in which this system would be effective. Factors which can affect microbial growth and polymer production include salinity, pH, temperature, divalent ions, presence of residual oil, and rock matrix. Flask tests and coreflooding experiments were conducted to optimize and evaluate the effectiveness of this system. Nuclear magnetic resonance imaging (NMRI) was used to visualize microbial polymer production in porous media. Changes in fluid distribution within the pore system of the core were ...
The emittances of hydrogen and deuterium negative ion beams produced by volume ion sources have been measured in a transverse plane normal to the beam trajectory. The extraction voltage was varied from 10 to 40 kV, and the transverse magnetic field in the Penning discharges was varied from 0.1 to 0.2 T. Measurements were made on beams with current densities up to 60 mA/cm/sup 2/ at Oak Ridge National Laboratory with an emittance scanner originally developed at Los Alamos National Laboratory. The beam profile at the scanner can be used to improve the accuracy of the emittance measurements. Other factorsaffecting emittance measurements are discussed. This analysis may be applicable to other ion sources. 6 figs.
In the Mediterranean arc, vines for wine production are mainly grown without the support of irrigation. Under such conditions, site variables affecting the extent and seasonal timing of water deficits are the dominant environmental constraints for grape production. Moreover, water availability and vine water status are the factors most comprehensively determining fruit composition and, thus, wine quality. Therefore, monitoring the extent of water stress in vines might be a valuable tool for the optimisation of grape yield and quality. The objective of this study was to evaluate the feasibility of using the reflectance based Water Index (WI) to estimate vine water status at the leaf and canopy levels. The study was conducted on Vitis vinifera cv. Chardonnay potted plants submitted to contra...
This paper presents an application of the state of the art and new trends for risk management of safety-related control and monitoring systems, currently applied in the industry. These techniques not only enable to manage safety and reliability issues but they also help in the control of quality and economic factorsaffected by the availability and maintenance of the system. The method includes an unambiguous definition of the system in terms of functions and a systematic analysis of hazardous situations, undesired events and possible malfunctions. It also includes the identification and quantification of the risk associated to the system. The required risk reduction is specified in terms of safety integrity levels. The safety integrity level results in requirements, preventive measures, possible improvements and recommendations to assure the satisfactory management of the risk.
The effects of reservoir layering and gravity segregation on nonisothermal injection and falloff tests are investigated. Results show that layering does not affect injection or falloff data if all the layers are permeable and accept fluids from the wellbore. In such cases, the average permeability, skin factor, and distance to the thermal front can be calculated using the techniques developed for homogeneous reservoirs. Special considerations have to be taken for cases where several layers are impermeable or are permeable but do not accept fluids of the well face. In the first case (impermeable layers), knowledge of the total thickness of the permeable layers is required for the existing techniques to be applied successfully. In the second case, the existing techniques cannot be applied, but characteristic responses from injection and falloff test are seen; therefore, this case can be identified easily. 13 refs., 8 figs.
Corrosion is said to be the most dominant factor which affects the physical life of ships and offshore structures. In order to secure the structural safety of ships and offshore structures, it is necessary to take measures to corrosion based on the prediction of condition of progressive corrosion. But such prediction is difficult because the behavior of corrosion`s progress is probabilistic. In this paper, probabilistic model, which could evaluate the degradation of coatings and the successive corrosion of steel members, was proposed in order to explain the tendency of the actual corrosion conditions of existing ships. Then, statistical inferences on the proposed model were made by applying the actual data on plate thickness measurements of Bulk Carriers` Cargo Hold. And validity of the proposed model was verified.
The large number of forms and types of pump equipment in common use have different purposes and varying application requirements. This text has been prepared to bring together necessary information for those who are required to select and apply pumps in systems for all kinds of fluids and purposes. It is not a design manual. It limits the discussion of design to those factors which are necessary for an understanding of pump operation. The book contains not only descriptive information of many types of designs, but also the effect of design variation on use, economy, and reliability. Systems, an integral part of application, are discussed, so that the user of such equipment may properly select and install machines to reliably and economically satisfy his requirements. Reading of appropriate sections of the text will indicate possible problems to be avoided, and economics to be gained. The engineering design of pumps is a science; their proper application is an art. ...
The use of electricity is indispensable to modern life. As Macao Special Administrative Region becomes a gaming and tourism center in Asia, modeling the consumption of electricity is critical to Macao's economic development. The purposes of this paper are to conduct an extensive literature review on modeling of electricity consumption, and to identify key climatic, demographic, economic and/or industrial factors that may affect the electricity consumption of a country/city. It was identified that the five factors, namely temperature, population, the number of tourists, hotel room occupancy and days per month, could be used to characterize Macao's monthly electricity consumption. Three selected approaches including multiple regression, artificial neural network (ANN) and wavelet ANN were used to derive mathematical models of the electricity consumption. The accuracy of these models was assessed by using the ...
Hoogenstraaten's heating rate method has generally been considered as a reliable method for determining thermoluminescence trapping parameters of first order glow peaks. However, experience has shown that in some cases the deviation between the heating rate method and glow curve fitting method can be quite significant (considering only the linear part of the heating rate plot, of course). In this study it is shown that one of the main reasons for this deviation can be a systematic increase of a temperature lag between the measured and real temperature of the sample with increasing heating rate. It appears that this systematic increase of the temperature lag affects the method in the range of low heating rates (linear part of the heating rates plots) more than has been previously realised. The effect of the temperature lag on Hoogenstraaten's heating rate method is a decrease in activation energy and frequency factor and is more important for ...
Hoogenstraaten's heating rate method has generally been considered as a reliable method for determining thermoluminescence trapping parameters of first order glow peaks. However, experience has shown that in some cases the deviation between the heating rate method and glow curve fitting method can be quite significant (considering only the linear part of the heating rate plot, of course). In this study it is shown that one of the main reasons for this deviation can be a systematic increase of a temperature lag between the measured and real temperature of the sample with increasing heating rate. It appears that this systematic increase of the temperature lag affects the method in the range of low heating rates (linear part of the heating rates plots) more than has been previously realised. The effect of the temperature lag on Hoogenstraaten's heating rate method is a decrease in activation energy and frequency factor and is ...
Polycyclic aromatic hydrocarbons (PAH`s) are ubiquitous hydrophobic organic pollutants in the marine environment. Many of the PAM`s are classified as possible carcinogens or mutagens, therefore they are of considerable concern to human and environmental health. The highest concentrations are found in coastal regions due to anthropogenic activities including oil spills, tanker operations, incomplete fossil fuel combustion and runoff. The sources and distribution of PAM`s in sediments are fairly well known, while the fate and transport of PAH`s in the marine environment are less known. Desorption is an important factor influencing the fate and transport of hydrophobic molecules at the seawater/sediment interface. The desorption of PAH`s from contaminated marine sediments to the water column/pore water affects the availability of the pollutant to biota. The sorption of PAH`s is determined in part by the organic carbon content of the sediments. The ...
Persons with a thermolabile form of the enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) have reduced enzyme activity and increased plasma homocysteine which can be lowered by supplemental folic acid. Thermolability of the enzyme has recently been shown to be caused by a common mutation (677C{sup {r_arrow}}T) in the MTHFR gene. We studied 41 fibroblast cultures from NTD-affected fetuses and compared their genotypes with those of 109 blood specimens from individuals in the general population. 677C{sup {r_arrow}}T homozygosity was associated with a 7.2 fold increased risk for NTDs (95% confidence interval: 1.8-30.3; p value: 0.001). These preliminary data suggest that the 677C{sup {r_arrow}}T polymorphism of the MTHFR gene is a risk factor for spina bifida and anencephaly that may provide a partial biologic explanation for why folic acid prevents these types of NTD. 13 refs., 1 fig., 1 tab.
The mechanisms involved in amino acid and sugar uptake by developing maize kernels were investigated. In the pedicel region of maize kernel, the site of nutrient unloading from phloem terminals, amino acids are accumulated in considerable amounts and undergo significant interconversion. A wide spectrum of enzymatic activities involved in the metabolism of amino acids is observed in these tissues. Subsequently, amino acids are taken up by the endosperm tissue in processes which require energy and the presence of carrier proteins. Conversely, no evidence was found that energy and carriers are involved in sugar uptake. This process of sugar uptake is not inhibited by metabolic inhibitors and shows nonsaturable kinetics, but the uptake is pH-dependent. L-glucose is taken up at a significantly reduced rate in comparison to D-glucose uptake. Based on analysis of radioactivity distribution ...
Bone scintigraphy was performed in 16 men with newly diagnosed prostatic carcinoma before orchiectomy as well as 2 weeks and 2 months after operation. The uptake in the lower thoracic and lumbar vertebrae was registered up to 240 min after injection of /sup 99m/Tc-MDP and was then calculated for each patient and vertebra. The relative standard deviation in measured uptake due to measuring technique was estimated to be +-7%. In eight patients, who had normal bone scintigraphies before orchiectomy, there were no changes in the uptake values after operation. The remaining eight patients had widespread metastatic involvement prior to treatment, six of these patients showed a so-called 'flare phenomenon' in the abnormal vertebrae which means an initial increase in uptake after operation followed by a decreased uptake in response to therapy. One patient had a ...
Bone scintigraphy was performed in 16 men with newly diagnosed prostatic carcinoma before orchiectomy as well as 2 weeks and 2 months after operation. The uptake in the lower thoracic and lumbar vertebrae was registered up to 240 min after injection of "9"9"mTc-MDP and was then calculated for each patient and vertebra. The relative standard deviation in measured uptake due to measuring technique was estimated to be #+-#7%. In eight patients, who had normal bone scintigraphies before orchiectomy, there were no changes in the uptake values after operation. The remaining eight patients had widespread metastatic involvement prior to treatment, six of these patients showed a so-called 'flare phenomenon' in the abnormal vertebrae which means an initial increase in uptake after operation followed by a decreased uptake in response to therapy. One patient had a continuously increased ...
Guard cells rely on import for their supply with reduced carbon. The authors tested by silicone oil centrifugation the ability of guard cell protoplasts to accumulated ({sup 14}C)-sucrose. Uptake rates were corrected after measurement of {sup 14}C-sorbitol and {sup 3}H{sub 2}O spaces. Sucrose uptake followed biphasic kinetics, with a high-affinity component below 1 mM external sucrose (apparent K{sub m} 0.8 mM at 25C) and a low-affinity nonsaturable component above. Uptake depended on pH (optimum at pH 5.0). Variations in the concentrations of external KCl, CCCP, and valinomycin indicated that about one-half of the sucrose uptake rate could be related to an electrochemical gradient across the plasmalemma. Total uptake rates measured at 5 mM external sucrose seem to be sufficient to replenish emptied plastids with starch within a few hours.
Sixteen patients with PAGET's disease of bone underwent quantitative bone scintigraphy with "9"9"mTc-MDP before and after a long-term treatment with carbocalcitonin, a synthetic analogue of eel calcitonin. The radionuclide study consisted in the blood pool and bone uptake measurement and in the bone avidity calculation (bone uptake - blood pool ratio). In our patients, a significant decrease in bone uptake and bone avidity was found, whereas the blood pool remained statistically unchanged. This behaviour could be accounted for the shift of the compact bone to a lamellar pattern. (orig.).
Sixteen patients with PAGET's disease of bone underwent quantitative bone scintigraphy with /sup 99m/Tc-MDP before and after a long-term treatment with carbocalcitonin, a synthetic analogue of eel calcitonin. The radionuclide study consisted in the blood pool and bone uptake measurement and in the bone avidity calculation (bone uptake - blood pool ratio). In our patients, a significant decrease in bone uptake and bone avidity was found, whereas the blood pool remained statistically unchanged. This behaviour could be accounted for the shift of the compact bone to a lamellar pattern.
Gallium imaging is increasingly being used for the early detection of complications in patients with AIDS. A 26-year-old homosexual man who was HIV antibody positive underwent gallium imaging for investigation of possible Pneumocystis carinii pneumonia. Widespread cutaneous focal uptake was seen, which was subsequently shown to be due to mycobacterium avium-intracellulare (MAI) septicemia. This case demonstrates the importance of whole body imaging rather than imaging target areas only, the utility of gallium imaging in aiding the early detection of clinically unsuspected disease, and shows a new pattern of gallium uptake in disseminated MAI infection.
Measurements of the retention of /sup 47/Ca and of /sup 203/Pb were made following their administration by intravenous injection. Translocation to bone was measured by ..gamma.. counting the feet of subjects. Uptake by bone of /sup 203/Pb was comparatively slow and extrapolation to the whole skeleton indicated that 20% of the dose has been taken up within 20 days. By time, a similar fraction of the dose has been excreted in urine. Uptake by bone of /sup 47/Ca was about 1.5-2 times the amount excreted in urine. Both the uptake by bone, and its excretion in urine, were more rapid than that of /sup 203/Pb due to the greater attachment of the latter to red blood cells. However, the plasma clearance rate for Pb, like that of Sr, was greater than that of Ca.
Inactive cells of Rhizopus arrhizus have been documented to exhibit a high thorium biosorptive uptake (170 mg/g) from aqueous solutions. The mechanism of thorium sequestering by this biomass type was investigated following the same method as for the uranium biosorption emchanism. The thorium sequestering mechanism appeared somewhat different from that of uranium. Experimental evidence is presented which indicates that, at optimum biosorption pH (4), thorium coordinates with the nitroge of the chitin cell wall network and, in addition, more thorium is adsorbed by the external section of the fungal cell wall. At pH 2 the overall thorium uptake is reduced. The kinetic study of thorium biosorption revealed a very rapid rate of uptake. Unlike uranium at optimum solution pH, Fe/sup 2 +/ and Zn/sup 2 +/ did not interfere significantly with the thorium biosorptive uptake capacity of R. arrhizus.
In an effort to develop octahedral metal complexes as chemotherapeutic and diagnostic agents targeted to DNA, it is critical to optimize the properties of their cellular uptake. Appending d-octaarginine...Full Text Available
Femoral head replacement was performed for femoral neck fracture or femoral head necrosis on 36 hips of 34 patients on whom Tc-99m MDP scintigraphy was done for analysis of radioisotope uptake around the prosthesis. In the cases with satisfactory clinical course after replacement surgery the uptake was high in the area between the prosthesis and the trochanter, in the area of the stem tip of the prosthesis and in the acetabular area. The high uptake decreased gradually and reached a normal level by 8 months after surgery. The cases with no decrease of high uptake by 8 months after surgery were considered to have had an eventful postoperative course associated with some complication such as infection, fracture, loosening etc. Tc-99m MDP scintigraphy was useful for early detection of complications and to evaluate progress of the operated patients. (author)
Forty-five patients with recent cervical hip fractures were included in a prospective, clinical, radiographic and sequential scintimetric study. Striking changes in radionuclide uptake over the entire hip region on the fracture side were found during the first 5 postoperative months. Fractures that healed without complications showed the highest relative femoral head uptake at 1 week and a peak value at 6 weeks, followed by a gradual decline at the subsequent examinations. Fractures with complications (redisplacement, nonunion, or late segmental collapse) showed a lower initial uptake and a more gradual increase and only a slight tendency towards increased uptake after 3 months. The accuracy in predicting nonunion with scintimetric examination alone is high both at 1 and at 6 weeks, and the accuracy is almost equally high with combined scintimetric, radiographic, and clinical assessment 3-5 months ...
Field studies among diverse biomes demonstrate that nitrogen concentration (% N) at leaf- and canopy-scales is strongly related to carbon uptake and cycling ...
Arbuscular mycorrhizal (AM) fungi are mutualistic symbionts living in the roots of 80% of land plant species, and developing extensive, below-ground extraradical hyphae fundamental for the uptake of...Full Text Available
Environmental arsenic is a world-wide health issue, making it imperative for us to understand mechanisms of metalloid uptake and detoxification. The predominant intracellular form is the highly mephitic...Full Text Available
As part of the Wisconsin road weather safety initiative, the objective of this study is to assess the effects of rainfall on the severity of single-vehicle crashes on Wisconsin interstate highways utilizing polychotomous response models. Weather-related factors considered in this study include estimated rainfall intensity for 15 min prior to a crash occurrence, water film depth, temperature, wind speed/direction, stopping sight distance and deficiency of car-following distance at the crash moment. For locations with unknown weather information, data were interpolated using the inverse squared distance method. Non-weather factors such as road geometrics, traffic conditions, collision types, vehicle types, and driver and temporal attributes were also considered. Two types of polychotomous response models were compared: ordinal logistic and sequential logistic regressions. The sequential logistic regression was tested with forward and backward ...
Context: The Balanced Budget Act (BBA) of 1997 allowed some rural hospitals meeting certain requirements to convert to Critical Access Hospitals (CAHs) and changed their Medicare reimbursement from prospective to cost-based. Some subsequent CAH-related laws reduced restrictions and increased payments, and the number of CAHs grew rapidly. Purpose: To examine factors related to hospitals' decisions to convert and time to CAH conversion. Methods: Eighty-nine rural hospitals in Iowa were characterized and observed from 1998 to 2005. Cox proportional hazards models were used to identify the determinants of time to CAH conversion. Findings: T-test and one-covariate Cox regression indicated that, in 1998, Iowa rural hospitals with more staffed beds, discharges, and acute inpatient days, higher operating margin, lower skilled swing bed days relative to acute days, and located in relatively high density counties were more likely to convert later or not convert before 2006. ...
The core bypass flow in a prismatic very high temperature reactor (VHTR) is an important design consideration and can have considerable impact on the condition of reactor core internals including fuels. The interstitial gaps are an inherent presence in the reactor core because of tolerances in manufacturing the blocks and the inexact nature of their installation. Furthermore, the geometry of the graphite blocks changes over the lifetime of the reactor because of thermal expansion and irradiation damage. The occurrence of hot spots in the core and lower plenum and hot streaking in the lower plenum (regions of very hot gas flow) are affected by bypass flow. In the present study, three-dimensional computational fluid dynamic (CFD) calculations of a typical prismatic VHTR are conducted to better understand bypass flow phenomena and establish an evaluation method for the reactor core using the commercial CFD code FLUENT. Parametric calculations changing several ...
The core bypass flow in a prismatic very high temperature gas-cooled reactor (VHTR) is one of the important design considerations which impacts considerably on the integrity of reactor core internals including operating fuels. The interstitial gaps are an inherent presence in the reactor core because of tolerances in manufacturing the blocks and the inexact nature of their installation. Furthermore, the geometry of the graphite blocks changes over the lifetime of the reactor because of thermal expansion and irradiation damage. The occurrence of hot spots in the core and lower plenum and hot streaking in the lower plenum (regions of very hot gas flow) will be affected by the bypass flow. In the present study, three-dimensional computational fluid dynamic (CFD) calculations of a typical prismatic VHTR are conducted to understand better the bypass flow phenomenon and establish the evaluation method in the reactor core using commercial CFD code FLUENT. Parametric ...
The grafted human glioblastoma cell CB109 was used as a model for intralesional therapy with 131I-labelled hyaluronectin glycoprotein (131I-HN). 131I-HN bound specifically to in situ hyaluronic acid (HA), a main component of the extracellular matrix which is involved in tumour invasion. Labelling experimental conditions were determined and, finally, 25 {mu}Ci/{mu}gHN, 1 {mu}g chloramine-T/{mu}gHN and a 60-s stirring period provided a 131I-HN preparation with an optimal affinity for HA (64% compared to unlabelled HN). Following intratumoral injection, 131I-HN was retained with a limited diffusion outside the tumour. On day 4 the radioactivity concentrated in the tumour was still 25 times greater than that in the liver, spleen and kidneys combined. For therapeutic assays, 65 {mu}Ci 131I-HN was injected into the tumour, resulting in a delivery of 6.8 Gy over a 7-day period. Controls received unlabelled HN, heat-inactivated HN, a mixture of inactivated HN plus free 131I or no treatment ...
The authors have found that heat-inactivated serum (57/sup 0/C for 1 hour) from normal chickens reduces the proliferation of mitogen-stimulated chicken and murine splenocytes as well as some transformed mammalian lymphoblastoid cell lines. Greater than a 50% reduction in /sup 3/H-thymidine incorporation was observed when concanavalin A (Con A)-activated chicken splenocytes that were cultured in the presence of 10% autologous or heterologous serum were compared to mitogen-stimulated cells cultured in the absence of serum. Normal chicken serum (10%) also caused greater than 95% suppression of /sup 3/H-thymidine incorporation by bovine (EBL-1 and BL-3) and gibbon ape (MLA 144) transformed lymphoblastoid cell lines. The only cell line tested that was not inhibited by chicken serum was an IL-2-dependent, murine cell line. Chicken serum also inhibited both /sup 3/H-thymidine incorporation and IL-2 synthesis by Con A-activated murine splenocytes. Suppression was caused by actions other than ...
This analysis is one of 10 reports that support the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN) biosphere model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes in detail the conceptual model as well as the mathematical model and its input parameters. This report documents development of input parameters for the biosphere model that are related to atmospheric mass loading and supports the use of the model to develop biosphere dose conversion factors (BDCFs). The biosphere model is one of a series of process models supporting the total system performance assessment (TSPA) for a Yucca Mountain repository. Inhalation Exposure Input Parameters for the Biosphere Model is one of five reports that develop input parameters for the biosphere model. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1-1. This figure shows the interrelationships among the ...
This study is a contribution to the growing body of work on the influence of changes in the composition of an acrylic bone cement on various properties of the curing and cured material. The focus is on one commercially-available acrylic bone cement brand, Surgical Simplex P, and three variants of it and a series of properties, namely, setting time, maximum exotherm temperature, activation energy and frequency factor for the polymerization reaction, diffusion coefficient for the uptake of phosphate buffered saline, at 37 degrees C, ultimate compressive strength (UCS), plane-strain fracture toughness, fatigue life (under fully-reversed tension-compression stress), hardness (H) and elastic modulus (both determined using quasi-static nanoindentation), and the variation of the storage and loss moduli with frequency of the applied force in a dynamic nanoindentation test. It was found that (a) a 68% reduction in the volume of the activator, N,N ...
Nuclear testing at and around the Nevada Test Site (NTS) resulted in widespread contamination from transuranic and other radionuclides, as well as from other toxic inorganic and organic contaminants. The type of contamination, including spatial distribution and type of radionuclides present, depends on the type of testing performed. Remediation of the contaminated areas is currently under way. The optimum in situ or ex situ remediation technology depends on the degree of interaction between the particular radionuclide, or contaminant in general, and the soil matrix, among other factors. The objective of this project was to evaluate the sorption affinity of NTS soils for common non-transuranic radionuclides. The sorption of cobalt (Co) on soils from two different areas of the NTS, namely the Little Feller and Cabriolet event sites, was studied. Experiments were conducted as a function of pH, solid concentration, total Co concentration, ionic strength, and particle ...
Hyperosmotic stress is known to significantly enhance net uptake of inorganic ions into plant cells. Direct evidence for cell turgor recovery via such a mechanism, however, is still lacking. In the...Full Text Available
1. Ro 15-8081 (Hoffmann-La Roche, Basle, Switzerland) is a novel mixed 5-HT/noradrenaline uptake inhibitor producing potent antinociceptive effects in animal pain models. 2. In healthy man, two models...Full Text Available
A study was undertaken to examine the uptake, distribution, and interaction of five activation products (Co-57, Be-7, Cs-134, Rb-83, and Mn-54) within the biotic and abiotic components surrounding the waste treatment lagoons of the Los Alamos Meson Physic...
Under certain growth conditions, the human colon adenocarcinoma cell line HT-29 exhibits intestinal enterocyte-like properties. The differentiated cells possess a brush border with the enzyme markers (aminopeptidase and sucrase) normally associated with the intestine. To aid in the characterization of the transport properties of these cells, the uptake of a non-metabolizable amino acid analog, "1"4C-#alpha#-methylaminoisobutyric acid (MeAIB) as examined in the HT-29-Al subclone which possesses a brush border. The cells exhibited a time-dependent uptake of MeAIB which was concentrative and sodium-dependent. The pH optimum for uptake was about 7.8. Uptake was inhibited by low temperature, 1 mM ouabain, or 0.5 mM dinitrophenol. A 1 hr-preincubation of the cells in an isotonic KCl solution resulted in a decreased uptake rate, suggesting that a negative membrane potential is important ...
1 Measurements of the binding of 12-alpha-[3H]-digoxin to the membranes of intact erythrocytes, erythrocytic 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells...Full Text Available
The authors present a case in which primary Ewing's sarcoma of the right petrous pyramid in a 9-year-old girl showed no uptake on a /sup 99m/Tc-pertechnetate nuclide angiogram. Intense uptake was present on a /sup 99m/Tc-polyphosphate bone scan, but a static brain scan was only minimally abnormal. The diagnosis and treatment of Ewing's sarcoma are reviewed.
Agrostis capillaris (Agrostis) and Calluna vulgaris (Calluna), two species with differing phenologies and widespread presence in upland areas of Britain where high Chernobyl fallout occurred, were grown in pot culture with varying concentrations of potassium in the rooting medium. Tissue content of potassium increased with increasing supply in both species. Roots, excised from these plants, were placed in a solution of "1"3"7Cs-labelled caesium chloride for 15 min to determine uptake potential. There were clear negative relationships between the rate of uptake of "1"3"7Cs by both species and (a) the concentration of potassium supplied and (b) plant issue potassium concentrations. With Agrotis, there was an approximately ten-fold difference in "1"3"7Cs uptake between potassium-deficient and optimum plants; with Calluna, it was approximately eight-fold. These results demonstrate the suppression of "1"3"7Cs ...
In a prior study, we demonstrated that certain disposable coils are contaminated with zinc and release substantial quantities of Zn during hemodialysis, producing high post-dialysis plasma Zn concentrations. The present investigation was designed to monitor plasma and dialysis fluid Zn and copper throughout dialysis and to estimate patient Zn and Cu uptake. Venous plasma, arterial plasma and coil chamber fluid were sampled periodically throughout dialysis; trace metal concentrations were determined by flame atomic absorption spectrophotometry. Release of considerable quantities of Zn from the coils into the dialysis fluid, with uptake into the patient's plasma, was found. Approximately one-half of the plasma Zn uptake occurred in the first 45 minutes. Coils from different lots released significantly different quantities of Zn. Patient uptake of Zn ranged from 3.2 mg-23.0 mg, with a mean of 15.0 ...
A new hydroxyiminoamide ligand, 1-(2-nitroimidazole-1-yl)-propanhydroxyiminoamide (N2IPA) was synthesized. The biodistribution of {sup 99m}Tc-N2IPA in mice bearing S180 tumor demonstrated that the complex showed a selective accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increased with time. At 4 hours after injection, the uptake ratios of tumor to muscle, blood, liver, heart, and lung reached 8.4, 1.5, 0.6, 2.9, and 2.3, respectively. Moreover, the tumor-to-liver uptake ratio steadily increased to 0.9 at 8 hours and 2.3 at 24 hours. The complex showed little uptake and quick clearance in blood, lung and other organs. Compared with other proposed hypoxia-imaging agents, this novel agent has advantages of higher tumor-to-muscle and tumor-to-blood uptake ratios and easier synthesis.
Skeletal radiotracer (sup(99m)Tc-HEDP) uptake was quantitated with and without the aid of a computer in 30 chronic dialysis patients with histologic evidence of renal osteodystrophy. Before scintigraphy, elevated soft-tissue activity due to the absence of renal radiotracer excretion was reduced by hemodialysis. The results were compared with those of a normal group and with the results of the biochemical and the bone morphometric studies of these patients. In all patients the radiotracer uptake was elevated, often markedly. In several patients with minimal histologic bone disease, however, soft-tissue activity could not be normalized by hemodialysis although its influence on the quantitative data could be further reduced (but not excluded) by computer evaluation of skeletal radiotracer uptake. Since the latter technique clearly distinguished the majority of the patients from the normals, it appears that computerized ...
Skeletal radiotracer (sup(99m)Tc-HEDP) uptake was quantitated with and without the aid of a computer in 30 chronic dialysis patients with histologic evidence of renal osteodystrophy. Before scintigraphy, elevated soft-tissue activity due to the absence of renal radiotracer excretion was reduced by hemodialysis. The results were compared with those of a normal group and with the results of the biochemical and the bone morphometric studies of these patients. In all patients the radiotracer uptake was elevated, often markedly. In several patients with minimal histologic bone disease, however, soft-tissue activity could not be normalized by hemodialysis although its influence on the quantitative data could be further reduced (but not excluded) by computer evaluation of skeletal radiotracer uptake. Since the latter technique clearly distinguished the majority of the patients from the normals, it appears that computerized ...
Characteristics of sugar uptake by immature maize embryos were determined in vitro utilizing a /sup 14/C-sugar solution incubation method. Hexose uptake rates were greater than those for sucrose, however, all showed biphasic kinetics. Glucose and fructose saturable components were evidence at <50 mM and sucrose at <5 mM. Chemical inhibitors (CCCP, DNP, NaCN, and PCMBS) and low temperature reduced sugar uptake. Sucrose influx was pH dependent while glucose was not. Embryos maintained a high sucrose to hexose ratio throughout development. At 25 days after pollination sucrose levels exceeded 200 mM while hexose levels remained below 5 mM. Glucose was rapidly converted to sucrose upon transport into the embryo. These circumstantial data indicate that sugar uptake by immature maize embryos is metabolically dependent and carrier mediated. Furthermore, sucrose transport appears to occur against its ...
Sodium-dependent high-affinity choline uptake was measured in the striatum, frontal cortex, hippocampus, and hypothalamus of rats after acute exposure (45 min) to pulsed (2 microseconds, 500 pps) or continuous-wave 2,450-MHz microwaves in cylindrical waveguides or miniature anechoic chambers. In all exposure conditions, the average whole-body specific absorption rate was at 0.6 W/kg. Decrease in choline uptake was observed in the frontal cortex after microwave exposure in all of the above irradiation conditions. Regardless of the exposure system used, hippocampal choline uptake was decreased after exposure to pulsed but not continuous-wave microwaves. Striatal choline uptake was decreased after exposure to either pulsed or continuous-wave microwaves in the miniature anechoic chamber. No significant change in hypothalamic choline uptake was observed under any of the exposure ...
Failure of multiple components due to a common cause represents one of the most important issues in evaluation of system reliability or unavailability. The frequency of such events has relatively low expectancy, when compared to random failures, which affect individual components. However, in many cases the consequence is a direct loss of safety system or mitigative safety function. For this reason, the modeling of a common cause failure (CCF) and its presentation in fault tree structure is of the uttermost importance in probabilistic safety analyses (PSA). Amongst the different techniques available to reduce the impact of common cause failures, the most important operations related technique, is that of staggered testing. In the TAPP 3,4 Level-1 PSA it was found that the contribution of Common Cause Failures to the Core Damage Frequency (CDF) was significant. The Common Cause Failures were modeled using the Alpha Factor Model. This model is ...
Pentaerythritol tetranitrate (PETN) is a relatively sensitive explosive used in many electroexplosive devices as well as in medicine. Of primary interest to LLNL is its use in items such as exploding bridgewire (EBW) detonators and exploding bridge foil initiators (EFI). In these devices the crystalline powder is pressed into a granular, low-density compact that can be initiated by an exploding wire or foil. The long-term stability of this pressed compact is of interest to weapon stockpile lifetime prediction studies. Key points about potential aging mechanisms can be summarized as follows: (1) There are a number of factors that can contribute to PETN instability. These include particle size, polymorphic phase transitions, crystal structure, impurities, moisture, occlusions, chemical incompatibility and biological (microorganism) action. of these factors the most important for long-term aging of high surface area powders used in detonators ...
Male rats were injected intravenously for 15 min with physiological saline (as control) (0.05 #mu#g/kg/min) or norepinephrine (NE) (0.1 #mu#g/kg/min) followed by 740 kBq of MIBG. Rats were injected for more 30 min (early stage group) and for more 4 hr (late stage group) with physiological saline or NE. Five MBq of "9"9"mTc-tetrofosmin (TF) was administered instead of MIBG in another group. The heart was isolated and uptake of MIBG or TF of right ventricle, apex, and left ventricle (divided into 8 parts) was measured. In control group, MIBG uptake of apex was significantly lower than that of lateral wall in both early and late groups. In NE group, MIBG uptake showed a tendency to decrease in both early and late groups. Compared with control group, the uptake of anterior wall in late group decreased significantly at NE 0.1 #mu#/kg/min. The TF uptake in control group was not different ...
Cultured 3T3-L1 cells have been used as a model system to investigate the mechanism of fatty acid uptake by adipose tissue. Using a 1:1 molar ratio of /sup 14/C-oleate and defatted bovine serum albumin (BSA), fatty acid (FA) uptake was quantitated at 4/sup 0/ and 37/sup 0/ as cell associated radioactivity. The profile of FA uptake in preadipocytes and adipocytes was biphasic; an initial rapid phase (1-20s) followed by a second slower phase (60-480s). At 37/sup 0/ the initial rate of FA accumulation in preadipocytes was identical to that in adipocytes, whereas the rate of accumulation during the second phase increased 7-fold (100 ..mu..M total FA) as a consequence of adipose conversion. When uptake measurements were made at 4/sup 0/ in adipocytes, the initial rate was identical to that at 37/sup 0/, however the rate of second phase decreased 5-fold. Incubation of /sup 14/C-BSA and nonradiolabeled FA with ...
Differentiated thyroid cancer (DTC) has variable degree of F-18 FDG avidity. The purpose of this study was to evaluate the relationship between F-18 FDG uptake and pathological or immunohistochemical features of DTC. DTC patients who underwent both pre-operative F-18 FDG PET/CT scan and surgery were included in the study. Maximum standardized uptake values (SUVmax) of primary tumor were calculated. If the primary tumor showed no perceptibly increased F-18 FDG uptake, region of interest was drawn based on finding of CT portion of the PET/CT images. Pathological and immunohistochemical markers such as presence of lymph node (LN) metastasis and underlying thyroiditis, tumor size, Ki-67 labeling index, expressions of EGFR, COX-2, and Galectin-3 were evaluated. Total of 106 patients was included (102 papillary carcinomas, 4 follicular carcinomas). The mean SUVmax of the large tumors (above 1 cm) was significantly higher than the ...
Visual experiments based on the smoke wire way were carried out on a small model of Straight-blade Vertical Axis Wind Turbine (SB-VAWT) to invest the relationship between the static flow field characteristics and the rotor azimuth angle. The test rotor had 3 blades with NACA0018 aerofoil. The rotor diameter and blade chord were 0.3m and 0.07m, respectively. Visual photos of the static flow path lines in and around the rotor were obtained at every 5 degrees of the azimuth angle. Further, numerical computations of the static flow filed were also carried out for comparison with the same situation as the visual tests and the static torques at different azimuth angles were calculated. According to the results of visual tests and computations, the dependence of the starting performance on the azimuth angle was discussed. The solidity is an important factoraffecting the starting performance of the SB-VAWT.
It needs accurate estimation of radiation level for verifying machinery and cable in Nuclear Power Plant. Therefore, in this study, we used ESR(Electron Spin Resonance) system for estimate dose of Alanine dosimeter. Alanine/ESR dosimetry, already known as a dosimetric method in medical and industrial field, was applied to estimate dose quantity at cable locations within a nuclear power plant as a part of equipment qualification program. Alanine/ESR dosimetry of absorbed dose range is 1 - 100 KGy. The alanine dosimeter is not significantly affected by temperature and fading is limited to 1% per year. The alanine dosimeters were fixed on the targeted cable or nearest position to measure dose quantity to get accurate value. Alanine dosimeters were scanned by commercially used two different ESR systems, e-scan and EMX series for alanine dosimeters. To estimate more accurate dose, two environmental correction factors, irradiation temperature and ...
(abridged) The accretion disk in AGN is expected to produce strong outflows, in particular a UV-line driven wind. Despite providing a good fit to the data, current spectral models of the X-ray spectrum of AGN observed through an accretion disk wind are ad-hoc in their treatment of the properties of the wind material. In order to address these limitations we adopt a numerical computation method that links a series of radiative transfer calculations, incorporating the effect of a global velocity field in a self-consistent manner (XSCORT). We present a series of example spectra from the XSCORT code that allow us to examine the shape of AGN X-ray spectra seen through a wind, for a range of velocity and density distributions, total column densities and initial ionization parameters. These detailed spectral models clearly show considerable complexity and structure that is strongly affected by all these factors. The presence of sharp features in the ...
There is currently considerable interest in identifying and quantifying the effects of welding procedure parameters and steel composition factors on the risk of cracking in pipeline girth welds that may be experienced during winter construction. Although low ambient temperatures, that may be experienced during winter construction, are generally assumed to increase the risk of cracking there has been little work to quantify the effects and to suggest how welding procedures should be modified for winter conditions. The present work was undertaken to calculate the effects of changes in welding parameters on the thermal cycle and the diffusion of hydrogen for a typical pipeline girth weld. A simple analytical method and the finite element method (FEM) were used. Both methods gave similar results but the simple method was very sensitive to the value of heat transfer coefficient. The results showed that the relation between the hydrogen diffusion parameter (tau) and ...
The properties of the highest velocity ejecta of normal Type Ia supernovae (SNe Ia) are studied via models of very early optical spectra of 6 SNe. At epochs earlier than 1 week before maximum, SNe with a rapidly evolving Si II 6355 line velocity (HVG) have a larger photospheric velocity than SNe with a slowly evolving Si II 6355 line velocity (LVG). Since the two groups have comparable luminosities, the temperature at the photosphere is higher in LVG SNe. This explains the different overall spectral appearance of HVG and LVG SNe. However, the variation of the Ca II and Si II absorptions at the highest velocities (v >~ 20,000 km/s) suggests that additional factors, such as asphericity or different abundances in the progenitor white dwarf, affect the outermost layers. The C II 6578 line is marginally detected in 3 LVG SNe, suggesting that LVG undergo less intense burning. The carbon mass fraction is small, only less than 0.01 near the ...
This paper examines the correlation between mechanical properties and the density, phase, and hydrogen content of deposited alumina layers, and compares them to those of sapphire and amorphous alumina synthesized through ion-beam irradiation of sapphire. Alumina films were deposited using electron beam evaporation of aluminum and co-bombardment with O{sub 2}{sup +} ions (30-230 eV) from an electron cyclotron resonance (ECR) plasma. The H content and phase were controlled by varying the deposition temperature and the ion energy. Sapphire was amorphized at 84 K by irradiation with Al and O ions (in stoichiometric ratio) to a defect level of 4 dpa in order to form an amorphous layer 370 nm thick. Nanoindentation was performed to determine the elastic modulus, yield strength and hardness of all materials. Sapphire and amorphized sapphire have a higher density and exhibit superior mechanical properties in comparison to the deposited alumina films. Density was determined to be the primary ...
High energy radiation was studied as a means for destroying hazardous organic chemical wastes. Tests were conducted at bench scale with a {sup 60}Co source, and at full scale (387 l/min) with a 1.5 MV electron beam source. Bench scale tests for both benzene and phenol included 32 permutations of water quality factors. For some water qualities, as much as 99.99% of benzene or 90% of phenol were removed by 775 krads of {sup 60}Co irradiation. Full scale testing for destruction of benzene in a simulated waste-water mix showed loss of 97% of benzene following an 800 krad dose and 88% following a 500 krad dose. At these loss rates, approximately 5 Mrad of electron beam irradiation is required to reduce concentrations from 100 g/l to drinking water quality (5 {mu}g/l). Since many waste streams are also inhabited by bacterial populations which may affect filtering operations, the effect of irradiation on those populations was also studied. {sup 60}Co ...
Terrestrial planets form in a series of dynamical steps from the solid component of circumstellar disks. First, km-sized planetesimals form likely via a combination of sticky collisions, turbulent concentration of solids, and gravitational collapse from micron-sized dust grains in the thin disk midplane. Second, planetesimals coalesce to form Moon- to Mars-sized protoplanets, also called "planetary embryos". Finally, full-sized terrestrial planets accrete from protoplanets and planetesimals. This final stage of accretion lasts about 10-100 Myr and is strongly affected by gravitational perturbations from any gas giant planets, which are constrained to form more quickly, during the 1-10 Myr lifetime of the gaseous component of the disk. It is during this final stage that the bulk compositions and volatile (e.g., water) contents of terrestrial planets are set, depending on their feeding zones and the amount of radial mixing that occurs. The main ...
Single-crystal neutron diffraction has been used to observe the interactions between deuterated ethanol (CD3CD2OH) and lysozyme in triclinic crystals of hen egg white lysozyme soaked in 25% (v/v) ethanol solutions. A total of 6047 observed reflections to a resolution of 2 A were used, and 13 possible ethanol sites were identified. The three highest occupied sites are close to locations for bromoethanol found in an earlier study by Yonath et al. [Yonath, A., Podjarny, A., Honig, B., Traub, W., Sielecki, A., Herzberg, O., and Moult, J. (1978) Biophys. Struct. Mech. 4, 27-36]. Structure refinements including a model for the flat solvent lead to a final crystallographic agreement factor of 0.097. Comparison with earlier neutron studies on triclinic lysozyme showed that neither the molecular structure nor the thermal motions were affected significantly by the ethanol. A detailed analysis of the ethanol-lysozyme contacts showed 61% of these to be ...
The transfer kinetics of the negatively charged glycosphingolipid II"3-N-acetylneuraminosyl-gangliotetraosylceramide (GM_1) were investigated by monitoring tritiated GM_1 movement between donor and acceptor vesicles. After appropriate incubation times at 45 "0C, donor and acceptor vesicles were separated by molecular sieve chromatography. Donors were small unilamellar vesicles produced by sonication, whereas acceptors were large unilamellar vesicles produced by either fusion or ethanol injection. Initial GM_1 transfer to acceptors followed first-order kinetics with a half-time of about 40 h assuming that GM_1 is present in equal mole fractions in the exterior and interior surfaces of the donor vesicle bilayer and that no glycolipid flip-flop occurs. GM_1 net transfer was calculated relative to that of ["1"4C]cholesteryl oleate, which served as a nontransferable marker in the donor vesicles. Factorsaffecting the GM_1 interbilayer transfer rate ...
This paper describes the graphical simulation of a traffic environment. The environment includes streets leading to an intersection, the intersection, vehicle traffic, and signal lights in the intersection controlled by different methods. The simulation allows for the study of parameters affecting traffic environments and the study of different control strategies for traffic signal lights, including conventional, fuzzy, and adaptive control methods. Realistic traffic environments are simulated including a cross intersection, with one or more lanes of traffic in each direction, with and without turn lanes. Vehicle traffic patterns are a mixture of cars going straight and making right or left turns. The free velocities of vehicles follow a normal distribution with a mean of the ``posted`` speed limit. Actual velocities depend on such factors as the proximity and velocity of surrounding traffic, approaches to intersections, and human response ...
In this paper the authors describe the ways poststructuralist discourses assisted us to reading and reflection on data collected as part of a traditional survey-style research study. The study--generated in response to widespread concern about falling male enrolment rates at the authors' regional university--focused upon factorsaffecting rural male school-leavers' decisions about postschool destinations, and upon these students' attitudes to higher education. In the paper that follows, the authors contest the dominant discourses that are frequently drawn on to explain differences in male and female higher education enrolment trends. They then focus upon the features of two of the more dominant stories that students told to explain this 'difference': stories about 'real men', and stories about the value of the 'practical' over the 'theoretical'. In addition, they present another story that draws upon girls' views of higher education. Together, ...
This conference was attended by decision makers throughout the supply chain in the natural gas industry who face the continuing challenges of changes in market mechanisms, pricing options, and transmission alternatives. It provided an opportunity to review issues affecting producers, shippers, marketers, and end-users in an environment of tight energy markets and high, inelastic demand. The constraints on adequate energy supplies are influenced by economic factors, current and future resources, materials, equipment, skilled labour, technology and financial capital. The 8 sessions of the conference dealt with the tight North American gas supply; the slow development of new supplies; resource access issues, including politics and supply security; the geopolitics of natural gas; impacts of high prices on the North American economy; energy industry impacts of high natural gas prices; domestic politics and high natural gas prices; and, radical ...
One of the most important factorsaffecting the postharvest life and quality of horticultural crops is temperature. Quality loss after harvest occurs as a result of physiological and biological processes, the rates of which are influenced primarily by product temperature. As the maintenance of market quality is of vital importance to the success of the horticultural industry, it is necessary not only to cool the product but to cool it as quickly as possible after harvest. The process of precooling is the removal of field heat which arrest the deteriorative and senescence processes so as to maintain a high level of quality that ensures customer satisfaction. This paper provides a critical review to portray precooling as an intricate part of temperature management and to highlight the importance of its utilisation for extending the shelf life and maintaining the quality of horticultural products with emphasis on cut flowers. Various different ...
The preparation of wood-plastic combinations (WPC) using combined methods for curing intermediate products and final products is described. In the first step, impregnated wood was irradiated using doses of 1 to 10 kGy in the presence of chemical initiators of polymerization. Thereafter, curing of this partly cured impregnating mixture was accomplished in the wood at elevated temperatures with the aid of chemical initiators of polymerization. Impregnation mixtures based on unsaturated polyester resins and methyl methacrylate, and the wood species European Beech (Fagus silvatica) and Black Alder (Alnus glutinosa) were used. The results indicate that this method of preparing WPC allows substantially lower radiation doses to be used, i.e., doses in the range of 1 to 2.5 kGy. These doses gelatinate the impregnation mixture in the wood so that the subsequent curing by chemical polymerization initiators proceeds without the impregnation mixture flowing out of the wood, and without forming ...
The preparation of wood-plastic combinations (WPC) using combined methods for curing intermediate products and final products is described. In the first step, impregnated wood was irradiated using doses of 1 to 10 kGy in the presence of chemical initiators of polymerization. Thereafter, curing of this partly cured impregnating mixture was accomplished in the wood at elevated temperatures with the aid of chemical initiators of polymerization. Impregnation mixtures based on unsaturated polyester resins and methyl methacrylate, and the wood species European Beech (Fagus silvatica) and Black Alder (Alnus glutinosa) were used. The results indicate that this method of preparing WPC allows substantially lower radiation doses to be used, i.e., doses in the range of 1 to 2.5 kGy. These doses gelatinate the impregnation mixture in the wood so that the subsequent curing by chemical polymerization initiators proceeds without the impregnation mixture flowing out of the wood, and without forming ...
A book has been written to introduce the physical aspects of the radiotherapy electron beam by presenting a summary of the developments in this field. The first chapter is a brief introduction to the technology of medical accelerators with emphasis on the electron beam production facilities. Chapter 2 describes the interaction processes at the atomic level once the electron beam enters the medium. Chapter 3 is concerned with the various properties of the electron beam purely from the clinical point of view. The electron beam algorithms and models for distribution calculations are covered in Chapter 4 with inclusion of age diffusion and multiple scattering approaches. The factorsaffecting the beam distribution in a patient, with inhomogeneities, surface irregularities, backscattering etc. are discussed in Chapter 5. The last two chapters are devoted to electron beam dosimetry including various dosimetric methods, specification and measurement ...
Recent changes in the US liability regime for oil pollution damage have intensified a policy debate about environmental liability limits. Economic theory suggests that some type of limit may be needed under certain conditions, and that such a limit should be set so that the marginal social benefit and cost are equal. However, it is unclear how a liability limit may be determined specifically for tanker shipping in US waters. We first examine conditions under which corner solutions (no liability or unlimited liability) are desirable. We then formulate a model to determine a socially optimal liability limit for oil pollution damage in US waters when a non-zero, finite liability limit is desirable. The model captures the tradeoff between less expensive energy supply and more stringent protection of the marine environment. Numerical simulations illustrate the properties of the model and major factorsaffecting the public policy decision regarding a ...
Projected scenarios for the proposed Yucca Mountain repository include significant periods of time when high relative humidity atmospheres will be present, thus the reaction processes of interest will include those known to occur under these conditions. The ideal natural analog for the proposed Yucca Mountain repository would consist of natural borosilicate glasses exposed to expected repository conditions for thousands of years; however, the prospects for identifying such an analog are remote, but an important caveat for using natural analog studies is to relate the reaction processes in the analog to those in the system of interest, rather than a strict comparison of the glass compositions. In lieu of this, identifying natural glasses that have reacted via reaction processes expected in the repository is the most attractive option. The goal of this study is to quantify molecular water diffusion in the natural analogs obsidian and tektites. Results from this study can be used in ...
Nowadays, the floating production, storage, and offloading (FPSO) units are used to marginal oil fields and deep seas, because of mobility and reduced lead time from discovery to first production. One of the methods for offloading is to moor a tanker alongside the FPSO unit. In this case motion response of the system becomes highly complex, and will be affected by many factors such as hydrodynamic interaction and mechanical connections between the vessels. In this study, a quite general method is developed which has taken into account the hydrodynamic interaction as well as the effects of connectors and mooring lines, in motion response analysis of a multi-body floating system. For this purpose, 3-D source distribution method is applied for hydrodynamic analysis, and linear stiffness matrices are introduced to represent the effect of connectors and mooring lines on the motion equations. The method has been used for motion analysis of a ...
Among in uterus exposed A-bomb survivors, fetal week is the most important factor to clarify the effects of A-bomb radiation on developmental process of the fetal brain. The study population of in utero exposed A-bomb survivors has first been established in 1953 in Hiroshima and in 1955 in Nagasaki. According to the estimated DS86 uterus absorption doses, fetal absorption doses obtained from the uterus doses, and intelligence quotient. Various studies on brain damage, including microcephaly, have been undertaken among in uterus exposed A-bomb survivors. Brain development has been shown to be affected during the fetal weeks 8-15 and 16-25. A review of the literature has revealed that 80% of the children with mental retardation and 15 of 18 cases of microcephaly (83%) were exposed in utero during the fetal week 8-15. Among children exposed at the fetal weeks 8-15 and 16-25, average learning was significantly decreased. The incidence of spasm was ...
Swirling flow in a direct injection diesel engine was measured by a laser doppler velocimeter. Piston cavity diameter and top clearance volume were changed as factorsaffecting swirling flow to study the distribution of swirling flow speed. When using the same intake port and changing the opening ratio of piston cavity, the distribution of swirling flow speed was different by the cavity during intake process but these agree just after opening intake valve and then become again different by cavity. When increasing top clearance and decreasing compression ratio, the axial symmetry of flow during commpression process increases. When changing piston cavity, and also when changing intake port, the mean swirling ratio in inside and outside areas of combustion chamber has common tendency to increase and decrease respectively. The mean swirling flow in the combustion chamber may be capable to be predicted by devising a model which can describe this ...
Swirling speed in a direct injection diesel engine was measured by a laser doppler velocimeter. Intake port geometry and engine speed were changed as factorsaffecting the swirling flow to study the distribution of swirling flow speed. The distribution of swirling flow speed changes complicatedly owing to axial nonsymmetry during intake process but becomes simple shape of axial symmetry during compression process after closing intake valve. But if this is assumed as the rigid swirl shape, the difference due to each intake port cannot be expressed but also large error may be possible to appear close to the cylinder wall. The distribution of swirling flow speed during compression process changes similarly, nearly proportinal to engine speed. But the similarity is higher at the middle period in compression process than at the end period in compression period. Axial distribution of local swirling ratio during compression process is nearly uniform. ...
In this paper we present results of our investigation into the relationship between urban microclimate and the local density of tree cover as measured in Sacramento, California. These results were obtained through analysis of data collected in a two-month long monitoring program with automatic weather stations installed at 15 residential locations throughout the city. Measured wind speeds showed a highly negative correlation with respect to tree cover. Daily peak air temperatures showed significant variation often differing from site to site by 2 to 4{degrees}C ({approx}3.5 to 7{degrees}F). A complex interaction between several competing factors is discussed leading to the conclusion that additional tree cover may actually increase urban air temperatures on synoptically cool days. It is suggested that this does not have a significant adverse affect in terms of overall summer urban cooling load. This is supported by an integrated analysis of the ...
With regard to a fracture system in the Hijiori hot dry rock artificial reservoir, an attempt was made on an interpretation which integrates different data. Major factors that characterize development and performance of an artificial reservoir are composed of a fracture system in rocks, which acts as circulating water paths, a heat exchange face and a reservoir space. The system relates not only with crack density distribution, but also with cracks activated by water pressure fracturing, cracks generating acoustic emission (AE), and cracks working as major flow paths, all of which are characterized by having respective behaviors and roles. Characteristics are shown on AE cluster distribution, crack distribution, production zone and estimated stress fields. Mutual relationship among these elements was discussed based on the Coulomb`s theory. The most important paths are characterized by distribution of slippery cracks. Directions and appearance frequencies of the ...
Fitness, (biometric measurements, reproduction) and behaviour that are ecologically relevant biomarkers in assessing the quality of estuarine sediments were studied by comparing the responses of the polychaete worm Nereis diversicolor - a key species in estuaries - along a pollution gradient. Intersite differences were shown for all the measured parameters: size-weight relationships, energy reserves as glycogen and lipids, sexual maturation patterns, total number of oocytes per female, total and relative fecundity, burrowing behaviour. The physiological and behavioural status of N. diversicolor was consistently disturbed in the larger, most contaminated estuaries (Loire and Seine, Fr.) compared to reference sites (Bay of Bourgneuf, Goyen estuary, Fr.). Many classes of potentially toxic chemicals present in these estuaries most likely contribute to these impairments but food availability may act as a confounding factor, interfering with the potential impact of ...
A micro-mechanistic understanding of bone fracture that encompasses how cracks interact with the underlying microstructure and defines their local failure mode is lacking, despite extensive research on the response of bone to a variety of factors like aging, loading, and/or disease. Micro-mechanical models for fracture incorporating such local failure criteria have been widely developed for metallic and ceramic materials systems; however, few such deliberations have been undertaken for the fracture of bone. In fact, although the fracture event in mineralized tissues such as bone is commonly believed to be locally strain controlled, until recently there has been little experimental evidence to support this widely held belief. In the present study, a series of in vitro experiments involving a double-notch bend test geometry are performed in order to shed further light on the nature of the local cracking events that precede catastrophic fracture in bone and to define ...
Most designers are not schooled in the area of human-interaction psychology and therefore tend to rely on the traditional ergonomic aspects of human factors when designing complex human-interactive workstations. Unfortunately, by ignoring the importance of the integration of the user interface at the psychophysiological level, the result can be ineffective use of a system leading to an inherently error- and failure-prone system. Therefore, to minimize failures in a human-interactive system, it is essential that designers understand how each user`s processing characteristics affect how the user gathers and processes information. By understanding the significant processing characteristics of the user, designers can implement practical and effective visual displays (or any other type of system) that are more desirable to all users. The material presented in this paper is based on a general study that involved users` perspective views of how visual ...
This study was performed to assess the possibility that patient age may independently affect improvements in health-related quality of life following percutaneous coronary intervention. One hundred five patients undergoing elective percutaneous coronary intervention at a single tertiary referral center between January 10, 2001 and January 6, 2002 were enrolled and prospectively evaluated. Health-related quality of life was assessed before and 1 year following percutaneous coronary intervention using Short Form-12 and the Seattle Angina Questionnaire. For the purpose of analysis, patients were divided according to age (younger than 60, 60-70, and older than 70 years). One hundred patients (95%) completed both questionnaires. Baseline characteristics among the age groups were similar in terms of gender, cardiac risk factors, and procedural details. All health-related quality-of-life indices demonstrated improvements with at least four variables ...
Brittleness and poor low-temperature thermal conductivity of A-15 compounds remain the major obstacles preventing the effective use of these superconductors in large-scale engineering applications. In order to circumvent these difficulties, a new type of ductile superconducting filamentary alloy has been developed recently by a simple metallurgical process which consists of melting the constituent elements and subsequent cold working and appropriate heat treatment. These superconducting materials are essentially Cu-base alloys containing a few percent of A-15 phase such as Nb_3Sn or V_3Ga which is in the form of fine filaments embedded in the Cu matrix. The emphasis of this work is on the formation of the A-15 phase in the Cu-base alloys and its correlation with superconducting properties such as transition temperature and critical current density. The formation of Nb_3Sn, Nb_3Al, V_3Si, and V_3Ga will serve as examples to illustrate the importance of some features in the phase ...
The current--density profile of a focused ion beam (FIB) has a central peak accompanied by broader ``wings`` that, while unimportant in lithographic applications, can lead to unwanted effects during an implantation operation. The origin of the wings, and hence the best way to minimize them, is not clear and needs further study. We have measured the line profiles of several of the ions available in our FIB machine as a function of a number of variables, under ultrahigh vacuum (UHV) conditions. No effects are observed from changes in emission current or deliberate defocusing of the objective lens. There are some changes with beam aperture and/or current, but the biggest differences seem to be associated with a change of source type and hence, possibly, with a change in the source/extractor configuration or in the alloy and the emission process. The wing amplitudes are appreciably lower than many previously observed, and their profiles, at least for the lighter ions studied (Be{sup ++}, ...
The current--density profile of a focused ion beam (FIB) has a central peak accompanied by broader ''wings'' that, while unimportant in lithographic applications, can lead to unwanted effects during an implantation operation. The origin of the wings, and hence the best way to minimize them, is not clear and needs further study. We have measured the line profiles of several of the ions available in our FIB machine as a function of a number of variables, under ultrahigh vacuum (UHV) conditions. No effects are observed from changes in emission current or deliberate defocusing of the objective lens. There are some changes with beam aperture and/or current, but the biggest differences seem to be associated with a change of source type and hence, possibly, with a change in the source/extractor configuration or in the alloy and the emission process. The wing amplitudes are appreciably lower than many previously observed, and their profiles, at least for the lighter ions studied (Be"+"+, Be"+, ...
Effects of ethanol in vitro on membrane vesicles were evaluated by monitoring "3"6Cl"- influx. Different assay parameters were tested to determine increased or decreased action of ethanol on GABA-activated chloride channels. The ability of 30 mM ethanol to augment "3"6Cl"- flux was seen at 0 degree C, in the absence of GABA, and at 34 degree C in the presence of GABA, using two different assay procedures. Picrotoxin blocked the direct effects of ethanol suggesting GABA_a involvement. Endogenous GABA in the medium surrounding the microsacs was assayed at different temperatures both in the presence and absence of GABA and ethanol. The direct effect of ethanol did not appear to involve the action of endogenous GABA. In addition to temperature effects on the assay, time of membrane storage also influenced ethanol action. Microsacs stored on ice for 2 hours or more lost their ability to respond to ethanol but not to GABA, pentobarbital or flunitrazepam. When these drugs were tested on ...
An experimental rig was set up to study the performance of a thermal storage unit using stearic acid as the heat storage medium. The unit mainly consists of an electrical heating rod and an outer tube, and the space between is an annulus that is filled with stearic acid. The thermal performance of the unit is measured, and the heat transfer characteristics of the melting processes of stearic acid are studied under different heat flux conditions to determine the influence of heat flux on the melting processes. A new type of fin is designed and fixed to the electrical heating rod to enhance the thermal response of the stearic acid. The experimental results show that the fin can improve the heat transfer of the melting process of the thermal storage unit greatly. The equivalent thermal conductivity of the PCM can be augmented by a factor up to 3. The analysis of the experimental results shows that the enhancement mechanism of the fin is attributed to its ability to ...
An experimental rig was set up to study the performance of a thermal storage unit using stearic acid as the heat storage medium. The unit mainly consists of an electrical heating rod and an outer tube, and the space between is an annulus that is filled with stearic acid. The thermal performance of the unit is measured, and the heat transfer characteristics of the melting processes of stearic acid are studied under different heat flux conditions to determine the influence of heat flux on the melting processes. A new type of fin is designed and fixed to the electrical heating rod to enhance the thermal response of the stearic acid. The experimental results show that the fin can improve the heat transfer of the melting process of the thermal storage unit greatly. The equivalent thermal conductivity of the PCM can be augmented by a factor up to 3. The analysis of the experimental results shows that the enhancement mechanism of the fin is attributed to its ability to ...
One of the energy-saving devices used on gas cooking appliances to eliminate the standing pilot is a spark ignition system. For safety, an ignition system must start promptly and be active whenever flowing gas is not ignited. To minimize noise and nuisance shock hazard, ignition must occur quickly and the sparking must be stopped as soon as ignition occurs and remain off as long as the flame is present. To accomplish both of these requirements, ignition systems have been devised which use the electrical current rectification property of a flame to sense it. These systems spark whenever the gas valve is on and a flame is not present. The factorsaffecting the performance of a spark ignition system are numerous, complex, and transient. All of these properties make quantification of performance difficult. A system is described which can evaluate the overall performance of ignition systems over significant periods of time and varieties of operating ...
Containing an epidemic at its origin is the most desirable mitigation. Epidemics have often originated in rural areas, with rural communities among the first affected. Disease dynamics in rural regions have received limited attention, and results of general studies cannot be directly applied since population densities and human mobility factors are very different in rural regions from those in cities. We create a network model of a rural community in Kansas, USA, by collecting data on the contact patterns and computing rates of contact among a sampled population. We model the impact of different mitigation strategies detecting closely connected groups of people and frequently visited locations. Within those groups and locations, we compare the effectiveness of random and targeted vaccinations using a Susceptible-Exposed-Infected-Recovered compartmental model on the contact network. Our simulations show that the targeted vaccinations of only 10% ...
In the development of high performance heat transfer surface on a compact heat exchanger, it was clarified that how reattachment point heat transfer and fluid flow are affected by channel width, at the same time, an evaluation of heat transfer performance and an investigation of optimum channel width were carried out. The channel system used in the experiment is as follows; (1) blow-off type with rectangular section channel, (2) span length of 200 mm, (3) wave length (pitch) of 80 mm, and (4) channel length of 12.5 wave length. The channel Reynolds number was set at about 10/sup 4/ which is relatively higher than the current studies. The results of the experiment were summarized as follows. (1) The channel width H has relevance to the phase difference between the fluid flow in cone portion of main stream and wave shape, the flow patterns are divided roughly into three types. These boundaries exist at P/H 3.0 and 1.5 (P: pitch, H: width). (2) The reattachment point ...
To evaluate the effectiveness of percutaneous transluminal angioplasty(PTA) and to determine the factorsaffecting the long-term patency rate in the management of insufficient hemodialytic arteriovenous fistula(AVF). Forty-nine cases of insufficient hemodialytic AVF were treated in 44 patients(native AVF:20, graft AVF:29, M:17, F:27, Age:22-70 years). In 28 thrombus patients, thrombolysis was performed with urokinase, and was followed by PTA. The initial success rate and complications of PTA were evaluated. According to the site and length of the stenosis, type and age of the AVF, the presence or abscence of thrombus, a history of diabetic mellitus, the patient's age, and the duration of renal failure, patency rates were compared within each subgroup using the Kaplan-Meier logrank test. The initial success rate of PTA for insufficient hemodialytic AVF was 88%(43/49), the patency rate of PTA was 67% at 6 months, and 50% at 12 months. ...
Economic analysis was performed at KAERI with the assistance of US DOE to compare single reactor fuel cycle costs for a once-through option and a thermal recycle option to operate 1 GWe of a PWR plant for its lifetime. A reference fuel cycle cost was first calculated for each option with best estimated reference input data. Then a sensitivity analysis was performed changing each single value of such fuel cycle component costs as yellow cake price, enrichment charges, spent fuel storage cost, reprocessing cost, spent fuel disposal cost and reprocessing waste disposal cost. Savings due to thermal recycle in requirements of uranium, conversion, and enrichment were examined using formulas suggested by US DOE, while MOX fabrication penalty was accounted for. As a result of the reference fuel cycle cost analysis, it is calculated that the thermal recycle option is marginally more economical than the once-through option. The major factorsaffecting ...
As a three-year joint university-industry effort, development of a generalized boiling transition analysis method has been started in 2002 aiming at enhanced capabilities of subchannel analysis for a wide variety of BWR-type fuel bundle geometry from ordinary BWR to tight lattice fuel bundles. For this purpose, five dominant factorsaffecting boiling transition phenomena have been identified on which our efforts of experimentation and numerical analyses are focused. In this report, as the first-year achievement, we will describe a master plan of the development and contents for experimental approaches to construct thermal-hydraulic databases. The databases will be utilized for the developments of constitutive equations to describe the basic characteristics of the elementary processes. The planned experiments are divided into two groups. One is air-water experiments at atmospheric pressure, and the other is steam-water experiments up to 1 MPa. ...
As a three-year joint university-industry effort, development of a generalized boiling transition analysis method has been started in 2002 aiming at enhanced capabilities of subchannel analysis for a wide variety of BWR-type fuel bundle geometry from ordinary BWR to tight lattice fuel bundles. For this purpose, five dominant factorsaffecting boiling transition phenomena have been identified on which our efforts of experimentation and numerical analyses are focused. In this report, as the first-year achievement, we will describe a master plan of the development and contents for experimental approaches to construct thermal-hydraulic databases. The databases will be utilized for the developments of constitutive equations to describe the basic characteristics of the elementary processes. The planned experiments are divided into two groups. One is air-water experiments at atmospheric pressure, and the other is steam-water experiments up to 1 MPa. ...
The interrelations between the factors causing the main effects on the primary circuit coolant flow rate distribution in the horizontal steam generator pipes in reactor facilities with the WWER type reactors under the modes with natural circulation are discussed. The criterion showing the presence or absence of coolant circulation reversal in bottom rows of the steam generator pipes is obtained. It is shown that large hydraulic non-uniformity in steam generator pipes operating in parallel under coolant natural circulation leads to decreasing the heat transfer surface efficiency under reactor facility emergency cooling, restricts its servicing capabilities. The circulation reverse in steam generator pipes under coolant natural circulation mode can give unfavourable effect on separate structural elements of the steam generators and as a result it can cause additional temperature strains in metal. The conclusion on provisions for improving the conditions for coolant ...
The piston bowl design is one of the most important factors that affect the air-fuel mixing and the subsequent combustion and pollutant formation processes in a direct-injection diesel engine. The bowl geometry and dimensions, such as the pip region, bowl lip area, and toroidal radius, are all known to have an effect on the in-cylinder mixing and combustion process. In order to understand better the effect of re-entrant geometry, three piston bowls with different toroidal radii and lip shapes were investigated using computational fluid dynamics engine modelling. KIVA3V with improved submodels was used to model the in-cylinder flows and combustion process, and it was validated on a high-speed direct-injection engine with a second-generation common-rail fuel injection system. The engine's performance, in-cylinder flow, and combustion, and emission characteristics were analysed at maximum power and maximum torque conditions and at ...
Radon exposure assessment in case-control studies on radon and lung cancer is generally based on contemporary radon concentration measurements, which can be affected by significant changes in the building structures or in living habits. Another method to estimate the radon exposure of the subjects is the recently developed retrospective dosimetry technique based on the {sup 210}Po surface activity from glass objects. In order to compare the results obtained by the two methods, a study has been carried out in a sample of 26 dwellings in Rome, with radon concentration values ranging from 28 to 623 Bq m{sup -3}. Retrospective detectors based on CR-39 and LR 115 were exposed on 50 glass objects in bedrooms and living rooms. The correlation factor between the two sets of data, after removing six extreme values, is 0.67, which is similar to results obtained in other validation studies of similar sample size. The correlation increases to 0.83 if the ...
Elevated nuclear factor kappa B (NF-@kB) activity and interleukin-6 (IL-6) secretion participates in the pathology of several age and inflammatory-related diseases, including age-related macular degeneration (AMD), in which retinal pigment epithelial cells are the key target. Recent findings reveal that heat shock protein 70 (Hsp70) may affect regulation of NF-@kB. In the current study, effects of Hsp70 expression on NF-@kB RelA/p65 activity were evaluated in human retinal pigment epithelial cells (ARPE-19) by using celastrol, a novel anti-inflammatory compound. Anti-inflammatory properties of celastrol were determined by measuring expression levels of IL-6 and endogenous NF-@kB levels during lipopolysaccharide (LPS) exposure by using enzyme-linked immunosorbent assays (ELISA). Cell viabil...
This study was undertaken to collect emissions performance data for Canadian and comparable American refineries. The objective was to examine parameters that affect refinery air emissions performance and develop methods or correlations to normalize emissions performance. Another objective was to correlate and compare the performance of Canadian refineries to comparable American refineries. For the purpose of this study, benchmarking involved the determination of levels of emission performance that are being achieved for generic groups of facilities. A total of 20 facilities were included in the benchmarking analysis, and 74 American refinery emission correlations were developed. The recommended benchmarks, and the application of those correlations for comparison between Canadian and American refinery performance, were discussed. The benchmarks were: sulfur oxides, nitrogen oxides, carbon monoxide, particulate, volatile organic compounds, ammonia and benzene. For ...
Changes in the physical and chemical processes during the ignition delay period of a gas-fueled diesel engine (dual-fuel engine) due to the increased admission of the gaseous fuels and diluents are examined. The extension to the chemical aspects of the ignition delay with the added gaseous fuels and the diluents into the cylinder charge is evaluated using detailed reaction kinetics for the oxidation of dual-fuel mixtures at an adiabatic constant volume process while employing n-heptane as a representative of the main components of the diesel fuel. In the examination of the physical aspects of the delay period, the relative contributions of changes in charge temperature, pressure, physical properties, pre-ignition energy release, heat transfer, and the residual gas effects due to the admission of the gaseous fuels are discussed and evaluated. It is shown that the introduction of gaseous fuels and diluents into the diesel engine can substantially affect both the ...
A simple one-step method to fabricate hierarchically porous TiO2/Pd composite hollow spheres without any template was developed by using solvothermal treatment. Pd nanoparticles (2-5 nm) were well dispersed in the mesopores of the TiO2 hollow spheres via in-situ reduction. In our experiment, polyvinylpyrrolidone played an important role in the synthetic process as the reducing agent and the connective material between TiO2 and Pd nanoparticles. HF species generated from solvothermal reaction leaded to the formation of TiO2 hollow spheres and Ostwald ripening was another main factor that affected the size and structure of the hollow spheres. The as-prepared TiO2/Pd composite hollow spheres exhibited high electrocatalytic activity towards the reduction of H2O2. The sensitivity was about 226.72 ?A mM-1 cm-2 with a detection limit of 3.81 ?M at a signal-to-noise ratio of 3. These results made the hierarchically porous TiO2/Pd composite a promising ...
Political leaders in numerous nations argue for an upper limit of the global average surface temperature of 2 K above the pre-industrial level, in order to attempt to avoid the most serious impacts of climate change. This paper analyzes what this limit implies in terms of radiative forcing, emissions pathways and abatement costs, for a range of assumptions on rate of ocean heat uptake and climate sensitivity. The primary aim is to analyze the importance of ocean heat uptake for radiative forcing pathways that temporarily overshoot the long-run stabilization forcing, yet keep the temperature increase at or below the 2 K limit. In order to generate such pathways, an integrated climate-economy model, MiMiC, is used, in which the emissions pathways generated represent the least-cost solution o...
Lead is a heavy metal which is widely used in paint industry, pigments, dyes, electrical components and electronics, plastic chemicals and in various other things. Since some of the lead salts are soluble in water, lead presents a potential threat to aquatic organisms. Studies dealing with invertebrates include those on mortality, growth and lead uptake in Lymnaea palustris and bioaccumulation of heavy metals in oysters and mussels. Little information exists regarding the effect of lead on the fresh water crustaceans. Hence the present investigation has been undertaken to study the uptake and loss of lead on exposure to subtoxic levels or organic and inorganic lead.
The deuterium uptake behavior of Zr-2.5Nb pressure tubes in Wolsung Unit 1 was analyzed in terms of longitudinal location, operation time, and coolant temperature. The results were compared with those obtained from Canadian CANDU reactors. The amount of deuterium uptake was higher at the outlet part than at the inlet part and was also higher when subjected to a longer operation time and a higher coolant temperature. The hydrogen uptake of Zr-2.5Nb in a hydrogen gas atmosphere was dependent on the microstructure of the alloy. The aged Zr-2.5Nb consisting of {alpha}-Zr and {beta}-Zr phases. The hydrogen in the alloy decreased the rate of oxidation. This could be explained in terms of the cathodic controlled reaction of Zr-2.5Nb oxidation. (author)
Effects of 2450-MHz circularly polarized microwave irradiation on central nervous system functions were studied. Pulsed (microsecond, 500 pps) microwaves decreased high-affinity sodium-dependent choline uptake in the hippocampus and frontal cortex of the rat. The effect on hippocampal choline uptake was blocked by pretreatment with narcotic antagonists. Continuous-wave microwaves of the same power density decreased choline uptake in the frontal cortex only. Furthermore, it was found that the effects of pulsed microwaves on central cholinergic activity are classically conditionable to cues in the exposure environment. The hypothesis that some of the neurological effects of pulsed microwave irradiation are caused by its effect on the auditory system was investigated. Effects of pink noise and pulsed microwaves were compared.
The C isotopic composition of CH4 emissions are strongly influenced by the pathway of CH4 formation. Contrary to data from other freshwater systems, soil gas and surface flux measurements made in the tropical rain forests of Puerto Rico strongly suggest that CH4 produced in these environments was derived from CO2 reduction, rather than from acetate consumption. This study explored the effects of bacterial competition for acetate, pH, and soil structure on the pathways of CH4 formation in tropical rain forest soils. Our goal was to test two principal hypotheses: (1) ferric iron-reducing bacteria out-competed methanogens for acetate, resulting in greater CO2 reduction rather than aceticlastic methanogenesis, and (2) the low pH of tropical rain forest soils favors CO2 reduction rather than aceticlastic methanogenesis. In addition, this study also investigated the effect of destroying soil aggregate structure on the pathways and rates of CH4 production. Ferric iron-reducing bacteria ...
Seafloor mapping and morphometric analysis of landslide scars can provide useful insights for marine geo-hazard assessment, as demonstrated by several studies performed on different geological settings. The availability of high-resolution multibeam bathymetry and long-range side scan sonar data on the submarine portions of Stromboli Volcano allow us to map and characterize the main mass-wasting features that affect, on the whole, about the 90% of its submarine extension. In particular, two main kinds of tsunamigenic landslides have been recognized and analyzed. Large-scale sector collapses (Fig. 1) are catastrophic events that mobilize 1-2 cubic kilometers of material, generating huge tsunami waves that may affect Stromboli and propagate in surrounding areas; related hazard is not very high, as they show recurrence periods of some (or more) thousand years. Conversely, medium-scale landslides are more hazardous, as they occur at higher frequency ...
Microbial dechlorination of polychlorinated biphenyls (PCBs) often stops although a significant number of removable chlorines remain. To determine the reason for the cessation, we investigated the limitation of organic carbon, PCB bioavailability, and inhibition by metabolic products. Enrichment with carbon sources did not induce additional chlorination, indicating the plateau was not due to depletion of organic carbon. The bioavailability was not limiting, since a subcritical micelle concentration of the surfactant, which enhanced desorption without inhibiting dechlorinating microorganisms, failed to lower the plateau. Neither was it due to accumulation of metabolites, since no additional dechlorination was detected when plateau sediments were incubated with fresh medium. Similarly, dechlorination was not inhibited in freshly spiked sediment slurries. Dechlorination ended up at the same level with nearly identical congener profiles, regardless of treatment. These results indicate that ...
Resistance to thyroid hormone (RTH) is an autosomal dominant disease caused by mutations in the human thyroid receptor beta gene on chromosome 3. Individuals with RTH have an increased incidence of attention deficit hyperactivity disorder (ADHD). The purpose of this study was to search for developmental brain malformations associated with RTH. Forty-three subjects (20 affected males [AM], 23 affected females [AF]) with resistance to thyroid hormone and 32 unaffected first degree relatives (18 unaffected males [UM], 14 unaffected females [UF]) underwent MRI brain scans with a volumetric acquisition that provided 90 contiguous 2 mm thick sagittal images. Films of six contiguous images beginning at a standard sagittal position lateral to the insula were analyzed by an investigator who was blind with respect to subject characteristics. The presence of extra or missing gyri in the parietal bank of the Sylvian fissure (multimodal association cortex) ...
Existing test procedures for measuring and rating thermal performance require the determination of the angular response of collectors in order to account for nonnormal incident beam irradiance. Angular response measurements for four different types of collectors, each type tested by three different laboratories, are presented and analyzed. Substantial differences, both within and between laboratories, are reported for the same type collectors. An analysis of the measurement procedure shows that experimentally determined angular response parameters are subject to relatively large uncertainties. The problem results to a large extent from measuring collector efficiencies at non-normal incident angles where measurement uncertainty is of the same order of magnitude as the efficiency reduction attributable to these off-normal angles. Other factors which can affect angular response measurements and the method of correlating results are also discussed. ...
This paper describes considerations given on factorsaffecting radon concentrations, and the radon concentration measurements in hot springs distributed in the northern part of Kumamoto Prefecture. As a result of analyzing radon concentration attenuation in the vertically upward direction using a diffusion equation, it was revealed that radon carrier gas velocities affect strongly the radon concentration, and the [sup 220]Rn source is limited to a very shallow bed below the ground surface. An inclined face was prepared against the [sup 222]Rn decay constant distribution using an inclined face analyzing method. The [sup 222]Rn concentration direction based on this inclined face harmonized approximately well with the hot spring distribution direction. Base rocks that well up hot springs were inferred to be granite from the concentration distribution and pH of chemical components in each hot spring. As a result of surveying ...
A necessary condition for crevice corrosion is that a crevice former create a sufficiently tight, restricted geometry on the metal surface to support the development of critical crevice chemistry. Crevice corrosion is affected by the crevice geometry (tightness) and the properties of the crevice former. The objective of this study is to determine the effect of the crevice former material on the evolution of localized corrosion-damage. A standard crevice corrosion test method is modified by (a) the use of ceramic, metal or polymer materials as the crevice former and (b) the variation of size and shape of the crevice. This study focuses on the post initiation stage of crevice corrosion and addresses factors that may limit the initiation of localized corrosion and also slow or stop the continued propagation of corrosion. Controlled crevice corrosion tests are performed under aggressive, accelerated conditions on Ni-Cr-Mo alloy C-22 and other ...
No prospective studies have evaluated the effects of correction of iron deficiency anemia on insulin resistance in non-diabetic premenopausal women with iron deficiency anemia. All patients were treated with oral iron preparations. Insulin resistance was calculated with the Homeostasis Model Assessment formula. All patients were dichotomized by the median for age and BMI to assess how the relationship between iron deficiency anemia and insulin resistance was affected by the age and BMI. Although the fasting glucose levels did not change meaningfully, statistically significant decreases were found in fasting insulin levels following anemia treatment both in the younger age (<40 years) (P=0.40) women and in the low BMI (27 kg/m) (P=0.22) subgroups but not in the older age (>= 40 years) and the high BMI (>-27Kg/m) subgroups. Post-treatment fasting insulin levels were positively correlated both with BMI (r=0.386, P=0.004) and post-treatment hemoglobin levels. ...
According to the California Earthquake Authority, only about 12% of current California residences are covered by any form of earthquake insurance, down from about 30% in 1996 following the 1994, M6.7 Northridge earthquake. Part of the reason for this decreasing rate of insurance uptake is the high deductible, either 10% or 15% of the value of the structure, and the relatively high cost of the premiums, as much as thousands of dollars per year. The earthquake insurance industry is composed of the CEA, a public-private partnership; modeling companies that produce damage and loss models similar to the FEMA HAZUS model; and financial companies such as the insurance, reinsurance, and investment banking companies in New York, London, the Cayman Islands, Zurich, Dubai, Singapore, and elsewhere. In setting earthquake insurance rates, financial companies rely on models like HAZUS, that calculate on risk and exposure. In California, the process begins with an official ...
BackgroundThe use of measurement tools is an essential part of good evidence-based practice; however, physiotherapists (PTs) are not always confident when selecting, administering,...Full Text Available
The use of municipal sewage sludge as a fertilizer in agriculture is a convenient method of disposal. However, sludge is often contaminated with toxic organic compounds such as dioxins, polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs), with implications for soil fertility and quality of crops for human and animal consumption. These compounds can be assimilated by intact plants or in-vitro cell-Culture systems. The amount of uptake depends on the plant species and on the physico-chemical conditions that influence, for example, molecular configuration; uptake rates are higher with low-molecular-weight and polar compounds. The xenobiotic can be converted to polar conjugates and hydroxylated metabolites that may also be toxic. In some cases, large amounts of the compound and/or its metabolic products are incorporated into non-extractable residues. The bound residues, especially those associated with carbohydrate ...
Uptake of the lipophilic cation triphenylmethylphosphonium into mesophyll protoplasts of oat (Avena sativa L. cv. “Garry”) approaches equilibrium at 3 to 4 hours. The...Full Text Available
Subcellular-fractionation techniques were used to characterize the endocytic pathway followed by ricin in rat liver in vivo and tentatively identify the site(s) at which the ricin interchain disulphide...Full Text Available
The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial cells (McCoy cells) was evaluated by a fluorometric assay. At...Full Text Available
The transport of arginine into isolated barley (Hordeum vulgare L.) mesophyll vacuoles was investigated. In the absence of ATP, arginine uptake was saturable with a Km...Full Text Available
The synovial and bone uptake of tracer in the knees of patients with rheumatoid arthritis (RA) was quantified using {sup 99}Tc{sup m}-hexamethyl propylene amine oxime-labelled leucocytes and {sup 99}Tc{sup m}-methylene diphosphonate (MDP), respectively. Significant neutrophil migration and MDP uptake occurred in the knees of patients with RA irrespective of the disease duration. In all but one patient neutrophil migration was reduced after intra-articular steroid injection. The change in MDP uptake after steroid injection was variable. There was a significant correlation between the percentage reduction in neutrophil migration and pain score, while the latter correlated poorly with the change in MDP uptake. The quantification of the neutrophil component of the inflammatory process is a sensitive index for monitoring RA activity and response to pharmacological interventions, while quantitative bone ...
The synovial and bone uptake of tracer in the knees of patients with rheumatoid arthritis (RA) was quantified using "9"9Tc"m-hexamethyl propylene amine oxime-labelled leucocytes and "9"9Tc"m-methylene diphosphonate (MDP), respectively. Significant neutrophil migration and MDP uptake occurred in the knees of patients with RA irrespective of the disease duration. In all but one patient neutrophil migration was reduced after intra-articular steroid injection. The change in MDP uptake after steroid injection was variable. There was a significant correlation between the percentage reduction in neutrophil migration and pain score, while the latter correlated poorly with the change in MDP uptake. The quantification of the neutrophil component of the inflammatory process is a sensitive index for monitoring RA activity and response to pharmacological interventions, while quantitative bone scintigraphy should not ...
1. Sacs 20 cm long were obtained from the upper half of the small intestine of bile fistula rats (bile duct cannulated 48 hours previously). The sacs were everted, filled with oxygenated phosphate...Full Text Available
The productivity of higher plants is, in part, dependent on transport of photosynthate from source to sink (in sugarcane, stalk) and upon its assimilation in cells of the sink tissue. In sugarcane, sucrose has been reported to undergo hydrolysis in the apoplast before uptake into the storage parenchyma, whereas recently, sucrose was reported to be taken up intact. This work was based on lack of randomization of ({sup 14}C)fructosyl sucrose accumulated after feeding tissue slices with this sugar. In this report, we present evidence from slices of stalk tissue that sucrose is taken up intact via a carrier-mediated, energy-dependent process. The evidence includes: (1) uptake of fluorosucrose, an analog of sucrose not subject to hydrolysis by invertase; (2) little or no randomization of ({sup 14}C) fructosyl sucrose taken up; (3) the presence of a saturable as well as a linear component of sucrose uptake; and (4) inhibition of ...
Amino acid transport in membrane vesicles of Bacillus stearothermophilus was studied. A relatively high concentration of sodium ions is needed for uptake of L-alanine (Kt = 1.0 mM) and L-leucine (Kt...Full Text Available
BackgroundSilica nanoparticles (SiNPs) are being formulated for cellular imaging and for nonviral gene delivery in the central nervous system (CNS), but it is unclear what potential...Full Text Available
The radioactivity in tobacco leaves collected from 15 different regions of Greece and before cigarette production was studied in order to find out any association between the root uptake of radionuclides...Full Text Available
French ... Orig. Title Scintigraphie osseuse quantifiee chez l'enfant et l'adolescent - repartition selon l'age des taux de fixation de diverses pieces osseuses normales.
Plantago media L. and Plantago maritima L. differ in their strategy toward salt stress, a major difference being the uptake and distribution of ions. Patch clamp techniques...Full Text Available
Peeled Avena sativa coleoptile sections have been used to study the control of solute uptake under conditions where the uptake is not limited by the cuticular barrier. In the presence of 2% sucrose, auxin enhances the rate at which the total osmotic solutes increase, but this appears to be a response to the increased growth rate, inasmuch as the auxin effect is eliminated when growth is inhibited osmotically. When sections are incubated in sucrose or in 10 millimolar NaCl, the osmotic concentration increases until a plateau is reached after 8 to 24 hours. Auxin has no effect on the initial rate of increase in osmotic concentration. This difference in steady-state osmotic concentration is, in part, a response to auxin itself, as it persists when auxin-induced growth is inhibited osmotically. The upper limit for osmotic concentration does not appear to be determined by the turgor pressure, inasmuch as a combination of sucrose and NaCl gave a ...
In this work we investigate the limits of uptake of metallic silver by two common metallophytes, Brassica juncea (BJ) and Medicago sativa (MS) and assess the form and distribution of the metal once sequestered by the plants. BJ accumulated up to 12.4 wt.% silver when exposed to an aqueous substrate containing 1,000 ppm AgNO{sub 3} for 72 h, however silver uptake was largely independent of exposure time and substrate silver concentration. MS accumulated up to 13.6 wt.% silver when exposed to an aqueous substrate containing 10,000 ppm AgNO{sub 3} for 24 h. In contrast to BJ there was a general trend for MS showing an increase in metal uptake with a corresponding increase in the substrate metal concentration and exposure time. In both cases the silver was stored as discrete nanoparticles, with a mean size of {approx}50 nm. According to the hyperaccumulation definition of Brooks et al. (Brooks RR, Chambers MF, Nicks LJ, ...
D-galactose, a monosaccharide rapidly phosphorylated within liver cells, is irreversibly removed from the portal circulation. We have studied the kinetic relations between the hepatic cell entry process...Full Text Available
Citrate transport via CitS of Klebsiella pneumoniae has been shown to depend on the presence of Na+. This transport system has been expressed in Escherichia coli, and uptake of citrate in E. coli membrane...Full Text Available
Sources of manganese are identified. Uptake and distribution of manganese in plants and man are discussed, and the role of manganese in metabolism is described. The epidemiology of manganese toxicity is outlined, permissible air concentrations are listed, and the symptoms of manganese toxicity and deficiency are described. 555 references, 32 tables.
The mechanism of metabolic energy production by malolactic fermentation in Lactococcus lactis has been investigated. In the presence of L-malate, a proton motive force composed of a membrane potential...Full Text Available
A classical velocity centrifugation technique was used to study the in vitro uptake of the new ketolide ABT-773 by human polymorphonuclear neutrophils (PMNs) and a myelomonoblastic cell line, PLB-985,...Full Text Available
The influence of insulin on unidirectional flux of glucose across the blood-brain barrier and on net uptake of glucose by the brain was investigated in seven fasting patients. The unidirectional extraction,...Full Text Available
In vivo effects of toxaphene on calcium pump activity in rat brain synaptosomes was studied. Male Sprague-Dawley rats were dosed with toxaphene at 0,25,50, and 100 mg/kg/day for 3 days and sacrificed 24 h after last dose. Ca/sup 2 +/-ATPase activity and /sup 45/Ca uptake were determined in brain P/sub 2/ fraction. Toxaphene inhibited both Ca/sup 2 +/-ATPase activity and /sup 45/Ca/sup 2 +/ uptake and the inhibition was dose dependent. Both substrate and Ca/sup 2 +/ activation kinetics of Ca/sup 2 +/-ATPase indicated non-competitive type of inhibition as evidenced by decreased catalytic velocity but not enzyme-substrate affinity. The inhibited Ca/sup 2 +/-ATPase activity and Ca/sup 2 +/ uptake were restored to normal level by exogenously added calmodulin which increased both velocity and affinity. The inhibition of Ca/sup 2 +/-ATPase activity and Ca/sup 2 +/ uptake and restoration by calmodulin suggests ...
In vivo effects of toxaphene on calcium pump activity in rat brain synaptosomes was studied. Male Sprague-Dawley rats were dosed with toxaphene at 0,25,50, and 100 mg/kg/day for 3 days and sacrificed 24 h after last dose. Ca"2"+-ATPase activity and "4"5Ca uptake were determined in brain P_2 fraction. Toxaphene inhibited both Ca"2"+-ATPase activity and "4"5Ca"2"+ uptake and the inhibition was dose dependent. Both substrate and Ca"2"+ activation kinetics of Ca"2"+-ATPase indicated non-competitive type of inhibition as evidenced by decreased catalytic velocity but not enzyme-substrate affinity. The inhibited Ca"2"+-ATPase activity and Ca"2"+ uptake were restored to normal level by exogenously added calmodulin which increased both velocity and affinity. The inhibition of Ca"2"+-ATPase activity and Ca"2"+ uptake and restoration by calmodulin suggests that toxaphene may impair active calcium transport ...
Francisella tularensis is a highly infectious bacterium causing the zoonotic disease tularaemia. During its infectious cycle, F. tularensis is not only exposed to the...Full Text Available
Mitochondria must uptake some phospholipids from the endoplasmic reticulum (ER) for the biogenesis of their membranes. They convert one of these lipids, phosphatidylserine, to phosphatidylethanolamine,...Full Text Available
Francisella tularensis requires iron (Fe) for growth, but the biologic sources of Fe for this organism are largely unknown. We found that Francisella sp. growing in...Full Text Available
Enhanced nutrient cycling basically involves close interaction between inorganic and organic sources of nutrients. Contrasting scenarios of nutrient cycling are found under intensive cropping production systems in most industrialized countries and traditional production systems predominant in many developing countries, where there is a net mining of soil nutrients due to crop harvest removal and erosion. Therefore, to enhance nutrient management in marginal tropical soils it is necessary to maximize the efficiency of nutrient uptake from various inorganic and organic sources with minimal environmental impact. It is postulated that one of the main approaches will be the identification and/or selection of plant genotypes for enhanced nutrient acquisition, in particular at low levels of soil available nutrients. In this context, use of various isotope techniques in examining root activity/distribution pattern and plant nutrient uptake is examined. ...
Growth of the malolactic bacterium Leuconostoc oenos was improved with respect to both the specific growth rate and the biomass yield during the fermentation of glucose-malate mixtures as compared with...Full Text Available
Data reveal that sodium pentobarbital anesthesia does not depress glucose uptake of neutrophils stimulated by the addition of live E. coli. E. coli viability was reduced equally in blood obtained before and after sodium pentobarbital anesthesia. Pre- and ...
The effects of temperature on rates of cellulose synthesis, respiration, and long-term glucose uptake were investigated using cultured cotton ovules (Gossypium hirsutum L. cv Acala...Full Text Available
The hepatic uptake rate for certain albumin-bound drugs and metabolites correlates poorly with their equilibrium unbound concentration in the plasma, suggesting that binding equilibrium may not always...Full Text Available
The fabrication and complete evaluation are described of a dihydropyridine in equilibrium pyridinium salt type redox system for the delivery of radioiodinated agents to the brain. The pivotal intermediate, N-succinimidyl (1-methylpyridinium iodide)-3-carboxylate was prepared by condensation of nicotinic acid and N-hydroxysuccinimide in the presence of dicyclohexylcarbodimide, followed by quaternization of III with methyl iodide. Tissue distribution studies of "1"2"5I-labeled 4-iodoaniline and the redox agents were performed in rats. ["1"2"5I]Iodoaniline initially showed moderate (0.58% dose/gm) brain uptake with subsequent release of the radioactivity from the brain. ["1"2"5I]Iodoaniline, when coupled to a dihydropyridine carrier showed higher uptake and retention in the brain. The ["1"2"5I]iodophenylethyl analogue showed uptake and retention in the brain to be very similar. Apparently the lipophilic agents cross the ...
BACKGROUND. In recognition of the emotional problems which frequently underlie somatic complaints, practices increasingly offer counselling as part of their services to patients. In an inner city practice,...Full Text Available
Competent Haemophilus cells recognize and preferentially take up Haemophilus DNA during genetic transformation. This preferential uptake is correlated with the presence on incoming DNA of an 11-base-pair...Full Text Available
Carbohydrate/citrate cometabolism in Lactococcus lactis results in the formation of the flavor compound acetoin. Resting cells of strain IL1403(pFL3) rapidly consumed citrate while...Full Text Available
Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ influx pathway involved in control of multiple cellular and physiological processes including cell proliferation. Recent evidence...Full Text Available
Background and AimsPlants from the family Lemnaceae are widely used in ecological engineering projects to purify wastewater and eutrophic water bodies. However, the biology of nutrient...Full Text Available
Amino acid transport was studied in membranes of the peptidolytic, thermophilic, anaerobic bacterium Clostridium fervidus. Uptake of the negatively charged amino acid L-glutamate, the neutral amino...Full Text Available
Ewing's sarcoma classically presents as a hot spot on bone scan as a result of increased vascularity of the tumor and new bone formation. Purpose We report and analyze an uncommon pattern of a 'cold' lesion in Ewing's sarcoma on bone scan and its pathophysiologic significance. Case report A 15-year-old boy complaining of thigh pain. CT scan evoked Ewing's sarcoma or osteitis. MRI evoked chronic osteitis. Scintigraphy showed a fairly intense and heterogeneous uptake on the femoral lesion and no abnormal uptake elsewhere. Biopsy showed none pathologic pattern. Three months later, a second biopsy concluded to Ewing's sarcoma. Bone scan showed a larger lesion with peripheral intense uptake centered by enlarged 'cold' area in the left femoral diaphysis and no evident bone metastasis. The patient underwent chemotherapy and surgery. Three months later, bone scan showed extensive skeletal metastasis. Conclusion Ewing's sarcoma ...
China operates 10 nuclear power reactors and has 5 more under construction. A large extension of nuclear power is expected by 2020. Nuclear generated electricity accounts for 2% of the total electric power generation. The Chinese policy is to have spent fuel reprocessed in China. So, final disposal include vitrified waste and some CANDU spent fuel for direct disposal. There is a legal framework in place in China to manage HLW. The China Atomic Energy Authority (CAEA) has the responsibility for setting policy on HLW disposal and implementing the disposal programme, while the National Nuclear Safety Administration (NNSA) and the State Environment Protection Agency (SEPA) are the regulatory bodies, which are responsible for licensing and reviewing of environment impact assessment report. The China National Nuclear Corporation (CNNC) is considered to be the actual implementer, conducting the major activities for HLW management. In the 1980's, China started generic research and development ...
The paper describes uptake of gaseous lodine-131 on silver impregnated organic resin, Amberlite IR-120, available at the Secondary Steam Generator (S.S.G.) Opening at T.A.P.S. in comparison with activated charcoal. The experiments are conducted in dry and wet conditions by soaking the impregnated resin and activated charcoal in distilled water for wet condition. The paper also describes the iodine sampler specially designed and fabricated for these experiments.
In this paper uptake of tritium by market foods from tritiated water vapor in the air is investigated using cereals and beans purchased in Deep River, Canada. The concentrations of tissue free water tritium (TFWT) and organically bound tritium (OBT) range from 12 to 79% and from 10 to 38% respectively, of that estimated for atmospheric water vapor of the sampling month. The specific activity ratios of OBT to TFWT were constant for cereals, but variable for beans. The elevated OBT was shown to be the result of isotopic exchange of labile hydrogen by the fact that washing the foods with tritium free-water reduced their tritium contents to levels characteristic of their production sites.
Six kinds of diamino-dithiol compounds are labelled with "9"9Tc"m by ligands exchange reaction. Their ligands exchange percentage is over 95%. The biodistribution of one of these compounds in mice shows 0.88% brain uptake after two minutes and 0.28% after 15 minutes respectively. Although the brain uptake is lower for this compound, it has longer retention in brain. So, the experiment results are valuable to the design of new brain imaging agent in the future.
Four /sup 125/I labeled mono- and diamines were prepared and evaluated as potential brain-imaging agents. The diamines are analogues of the previously reported /sup 75/Se labeled diamines, which show high brain uptake and retention. All of the radioiodinated amines display high initial brain uptake in rats after intravenous injection (1.7-2.4% dose/organ). The xylylenediamines show prolonged brain retention (t1/2 approximately 18 h), which is desirable for brain imaging. In contrast, the benzylamine is rapidly cleared from brain tissue (t1/2 approximately 15 min).
Posttraumatic tibia valga is a well-recognized complication following fracture of the upper tibial metaphysis in young children. We present a case of a child who developed a valgus deformity following fracture of the proximal tibia and fibula in which quantitative bone scintigraphy at 5 months after injury demonstrated increased uptake at the proximal tibial growth plate with proportionally greater uptake on the medial side. This finding suggests that the valgus deformity in this patient was due to a relative increase in vascularity and consequent overgrowth of the medial portion of the proximal tibial physis.
Posttraumatic tibia valga is a well-recognized complication following fracture of the upper tibial metaphysis in young children. We present a case of a child who developed a valgus deformity following fracture of the proximal tibia and fibula in which quantitative bone scintigraphy at 5 months after injury demonstrated increased uptake at the proximal tibial growth plate with proportionally greater uptake on the medial side. This finding suggests that the valgus deformity in this patient was due to a relative increase in vascularity and consequent overgrowth of the medial portion of the proximal tibial physis.
Thirty-two patients with AIDS related complex (ARC) or acquired immunodeficiency syndrome (AIDS) underwent /sup 67/Ga scans as part of their evaluation. Three patterns of /sup 67/Ga biodistribution were found: lymph node uptake alone; diffuse pulmonary uptake; normal scan. Gallium-67 scans were useful in identifying clinically occult Pneumocystis carinii pneumonia in seven of 15 patients with ARC who were asymptomatic and had normal chest radiographs. Gallium scans are a useful ancillary procedure in the evaluation of patients with ARC or AIDS.
An in vitro system for studying Pu uptake by, and removal from, macrophages was developed to provide data for the actinide therapy program. We have shown that "2"3"9PuO_2 particle uptake in vitro resembles the process in vivo with respect to the intracellular localization of phagocytized particles. At the end of 7 days of culture of Pu-loaded cells, 54% of the cells were viable even though 71% of the cells in the culture initially contained enough "2"3"9PuO_2 to deliver more than 53 intracellular #alpha#-disintegrations.
The goals of this paper are to describe the fabrication and complete evaluation of a dihydropyridine <- -> pyridinium salt type redox system for the delivery of radioiodinated agents to the brain. Tissue distribution studies of "1"2"5I-labeled 4-iodoaniline and the redox agents were performed in rats. ["1"2"5I]Iodoaniline initially showed moderate brain uptake with subsequent release of the radioactivity from the brain. ["1"2"5I]Iodoaniline, however, when coupled to a dihydropyridine carrier showed significantly higher uptake and retention in the brain. (author).
B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin B2 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for GC risk were calculated ...
Textured silicon nitride (Si_3N_4) has been intensively studied over the past 15 years because of its use for achieving its superthermal and mechanical properties. In this review we present the fundamental aspects of the processing and anisotropic properties of textured Si_3N_4, with emphasis on the anisotropic and abnormal grain growth of #beta#-Si_3N_4, texture structure and texture analysis, processing methods and anisotropic properties. On the basis of the texturing mechanisms, the processing methods described in this article have been classified into two types: hot-working (HW) and templated grain growth (TGG). The HW method includes the hot-pressing, hot-forging and sinter-forging techniques, and the TGG method includes the cold-pressing, extrusion, tape-casting and strong magnetic field alignment techniques for #beta#-Si_3N_4 seed crystals. Each processing technique is thoroughly discussed in terms of theoretical models and experimental data, including the texturing mechanisms ...
The 177 underground storage tanks at the DOE's Hanford Site contain an estimated 180 million tons of high-level radioactive wastes. It is desirable to remove and concentrate the highly radioactive fraction of the tank wastes for vitrification. Resorcinol-formaldehyde (R-F) resin, an organic ion-exchange resin with high selectivity and capacity for the cesium ion, which is a candidate ion-exchange material for use in remediation of tank wastes. The report includes information on the structure/function analysis of R-F resin and the synthetic factors that affect performance of the resin. CS-100, a commercially available phenol-formaldehyde (P-F) resin, and currently the baseline ion-exchanger for removal of cesium ion at Hanford, is compared with the R-F resin. The primary structural unit of the R-F resin was determined to consist of a 1,2,3,4-tetrasubstituted resorcinol ring unit while CS-100, was composed mainly of a 1,2,4-trisubstituted ring. ...
The Ho-Chunk Nation is interested in documenting water-quality conditions in streams adjacent to their Reservation lands in Wisconsin and developing management plans to protect these water resources. The Nation uses these waterways for recreation and as a source for food, and therefore, is dedicated to maintaining and restoring their quality. Ho-Chunk lands encompass more than 10,000 acres ranging primarily over 17 counties in Wisconsin. The study areas for this report include streams adjacent to Ho-Chunk Nation residential lands: Potch-Hah-Chee, Sandpillow, Mission, Bluewing, Chakh Hah Chee, Winnebago Heights, Indian Heights, and Ho-Chunk Village. These residential areas, or housing sites, are located along or near the Middle Branch Embarrass, Black, Lemonweir, and Wisconsin Rivers or their tributaries. Water-quality data were compiled and summarized, and basin maps showing land cover and previous sampling sites are presented. Qualitative assessments of factors ...
Nuclear Act of Korea requires the manifest of low and intermediate level radioactive waste generated from nuclear power plants and other nuclear facilities prior to deliver to a disposal sites. Individual history records of the radioactive waste should be described the information about the activity of nuclides in the drum, total activity, weight, the type of waste. So a fully automated nuclide analysis assay system(non-destructive) of a radwaste drum was developed. For the nuclides that could not be analysed directly by MCA, the activities of the representative {gamma}-emitters(Cs-137, Co-60) contained in the drum were measured by using that system. Then the scaling factors were used to calculate the activities of {alpha} - and {beta}-emitters. This assay system divided a drum into 8 segments, a segment into 8 sectors to minimize analysis error, and used several methods(transmission ratio, differential peak absorption, mean density correction), with a individual ...
Purpose: Reconstruction of organ doses of selected organs and tissues from radiographic settings and exposure data collected during chest X-ray examinations of children of various age groups performed in Dr. von Hauner's Kinderspital (children's hospital of the University of Munich, DvHK) between 1976 and 2007. Materials and Method: The dosimetric data of all X-ray examinations performed since 1976 at DvHK were stored electronically in a database. After 30 years of data collection, the database now includes 305 107 radiological examinations (radiographs and fluoroscopies), especially 119 150 chest radiographs of all age groups. Reconstruction of organ doses in 40 organs and tissues in X-ray examinations of the chest was performed based on the conversion factor concept. Results: The radiation exposure of organs in projection radiography is determined by the exact site of the organs relative to the edges of the X-ray field and the beam direction of ...
Full text: The general population is daily exposed to chronic, low doses of ionizing radiation (IR) from both natural and artificial sources. The biological consequences of acute, high dose IR exposure can be readily determined; however, the nature and significance of low dose, low dose-rate IR effects are still the subject of debate. Confounding the issue, are the phenomena collectively referred to as the Radiation-induced Bystander Effect (RIBE). The RIBE describes a collection of in vitro observations that suggest the presence of a soluble, transmissible factor(s) released from irradiated cells that can induce a biological response in un-irradiated cells. The induction, nature and magnitude of the RIBE varies between cell culture systems, radiation sources and end-points measured. Efforts to confirm the presence of the RIBE in vivo have been confined to in vivo-like culture systems and limited work with tumour and bone-marrow transplantation models. Validation ...
The Creating Wetlands in the Oil Sands Reclamation workshop was held to solicit expert views from leading authorities in a number of disciplines related to the creation and study of wetlands, as well as to investigate challenges in the creation of wetlands in reclaimed oil sands landscapes. This document provided a detailed transcript of each presentation and all discussions that followed. The workshop was divided into 5 sessions: (1) wetlands background information; (2) groundwater conditions and boreal wetlands; (3) creating wetland types; (4) wildlife in boreal wetlands and traditional environmental knowledge; and (5) treatment wetlands. An expert panel overview provided presentations on post-mining restoration of boreal landscapes in oil sands regions; the creation of fens, marshes and shallow water wetlands at oil sands sites and the restoration of damaged peatlands. A outline of the physical scale of the oil sands mining disturbances was provided during the first session, as well ...
The potential application of radioisotopes are not discussed in this review of trypanosome pathogenesis in cattle. Initially, structural changes in the lymphoid system are characterized by marked proliferation and germinal centre formation, whereas in long-standing infections the lymphoid organs become depleted. These changes appear associated with immunodepression. Anaemia dominates the clinical disease syndrome in bovine trypanosomiasis. It develops with the onset of parasitaemia and is largely haemolytic, resulting from increased red blood cell destruction by phagocytosis. Several factors may be involved in this process including haemolysins produced by the trypanosome, immunological mechanisms, fever, disseminated intravascular coagulation and an expanded and active mononuclear phagocytic system. During this phase of the disease, cattle respond well to chemotherapy. However, in later phases of the disease, when trypanosomes cannot be detected, the anaemia ...
We examined the effect of the trophic protein, nerve growth factor (NGF), on cultures of fetal rat neostriatum and basal forebrain-medial septal area (BF-MS) to define its role in brain development. Treatment of cultures with NGF resulted in an increase in the specific activity of the cholinergic enzyme choline acetyltransferase (CAT) in both brain areas. CAT was immunocytochemically localized to neurons. In the BF-MS, NGF treatment elicited a marked increase in staining intensity and an apparent increase in the number of CAT-positive neurons. Moreover, treatment of BF-MS cultures with NGF increased the activity of acetylcholinesterase, suggesting that the cholinergic neuron as a whole was affected. To begin defining mechanisms of action of NGF in the BF-MS, we detected NGF receptors by two independent methods. Receptors were localized to two different cellular populations: neuron-like cells, and non-neuron-like cells. Dissociation studies with ...
The first part of a systematic investigation is presented of surface treatments affecting the fatigue behavior of smooth and notched quenched and tempered (Q and T) specimens made of a B-Mn SS2131 ({approx}AISI 15B21H) steel. In this part, the effects of plasma nitriding (nitriding temperature=480 C, time=24 h) on the fatigue strength and notch sensitivity were investigated. Constant stress amplitude plane reversed bending fatigue tests (R=-1) at 47 Hz were conducted using cylindrical plasma nitriding (PN) and Q and T steel specimens with K{sub t}=1.05 and 1.7. The compound layer was found to consists of {epsilon}-phase and {gamma}`-phase. S-N curves show that plasma nitriding improves the fatigue limit by 53 and 115% of Q and T smooth and notched specimens, respectively. The fatigue strength of smooth specimens is improved through the whole fatigue life but only for long fatigue lives for notched specimens. Plasma nitriding reverses the low notch sensitivity (at ...
The set of activities performed by SENTECH, Inc. addressed the specific recommendations provided to the Department of Energy (DOE) by its advisors, including the Hydrogen Technical Advisory Panel and the review panel members of the DOE Annual Hydrogen Program Review. SENTECH`s efforts were conducted under five tasks: Task 1: Technology and Process Analysis; Task 2: Hydrogen Information Development and Transfer; Task 3: Educational Products; Task 4: Systems Analysis; and Task 5: Life Cycle Costs. SENTECH activities were executed in two broad areas--analysis and technology transfer. The analytical tasks undertaken in FY97 were focused on two types of analysis--systems analysis and technical/economic assessments. These analytical activities benefit DOE by providing data that allow it to define the strategic goals of the hydrogen R and D program. By collecting analysis of the energy efficiency, environmental externality, and economic competitiveness factors of hydrogen ...
As low temperature cryocoolers become more frequently used to cool superconducting magnets, it becomes increasingly apparent that the connection between the cooler and the magnet has an effect on the design and performance of the magnet. In general, the use of small coolers can be considered in two different temperature ranges; (1) from 3.8 to 4.8 K for magnet fabricated with LTS conductor and (2) from 18 to 35 K for magnets fabricated using HTS conductor. In general, both temperature ranges call for the use of a two-stage cooler. The best method for connecting a cooler to the magnet depends on a number of factors. The factors include: (1) whether the cooler must be used to cool down the magnet from room temperature, (2) whether the magnet must have one or more reservoirs of liquid cryogen to keep the magnet cold during a loss of cooling, and (3) constraints on the distance from the cooler cold heads and the magnet and its shield. Two methods ...
Mutations in transcription factors hepatocyte nuclear factors (HNF)-1#alpha# and HNF-1#beta# cause maturity-onset diabetes of the young (MODY) types 3 and 5, respectively. HNF-1#alpha# and HNF-1#beta# mutations are well studied in some tissues, but the mechanism by which HNF-1#alpha# and HNF-1#beta# mutations affect sucrase-isomaltase (SI) transcription in the small intestine is unclear. We studied the effects of 13 HNF-1#alpha# mutants and 2 HNF-1#beta# mutants on human SI gene transcription, which were identified in subjects with MODY3 and MODY5, respectively. Transactivation activity of 11 HNF-1#alpha# and 2 HNF-1#beta# mutants was significantly lower than that of wild (wt)-HNF-1#alpha# and wt-HNF-1#beta#. Furthermore, in co-expression studies with mutant (mu)-HNF-1#alpha#/ wt-HNF-1#beta# and wt-HNF-1#alpha#/mu-HNF-1#beta#, the combination of mu-HNF-1#alpha# (P379fsdelCT and T539fsdelC)/wt-HNF-1#beta# impaired SI ...
Increased use of wetlands for habitat and water quality improvement emphasize the need for further study of abiotic-biotic interactions in these systems. This research examined contaminant assimilation within the water column of two newly created Colorado prairie wetlands (RMA3 and RMA4). To examine the influence of abiotic factors (e.g., alkalinity, suspended solids), ten chronic toxicity tests were performed from December 1991 through November 1993. In the first set of tests, Ceriodaphnia dubia were exposed to water from the two wetlands which was spiked with various concentrations of zinc. These tests suggested that water from RMA4 had higher contaminant assimilative capacity than water from RMA3. Preliminary analysis suggested suspended solids, pH, conductivity, and temperature were important factorsaffecting neonate production by C. dubia when exposed to zinc-spiked wetland water. To test the importance of suspended ...
Executive summary 1. Few studies have to date explained consumer attitudes and purchase decisions with regard to genetically engineered food products. However, the increased marketing of genetically engineered food products and the considerable concern that consumers seem to express with regard to the technology call for the development of a theoretical basis for research into these issues. 2. The aim of the paper is to present three models which we have developed to explain consumer attitudes, buying behaviour and attitude change with regard to genetically engineered food products. All three models build on established consumer behaviour theory and on existing and comparable research in the field. 3. Consumer attitudes toward genetic engineering in food products are explained in an attitude model that builds on Fishbein's multiattribute attitude model. The model deviates from Fishbein's model in a number of ways: there is an explicit distinction between perceived benefits and risks ...
Reinjection of spent geothermal brine is a common means of disposing of geothermal effluents and maintaining reservoir pressures. Contrary to the predictions of two-fluid models (two-viscosity) of nonisothermal injection, an increase of injectivity, with continued injection, is often observed. Injectivity enhancement and thermally-affected pressure transients are particularly apparent in short-term injection tests at the Los Azufres Geothermal Field, Mexico. During an injection test, it is not uncommon to observe that after an initial pressure increase, the pressure decreases with time. As this typically occurs far below the pressure at which hydraulic fracturing is expected, some other mechanism for increasing the near-bore permeability must explain the observed behavior. This paper focuses on calculating the magnitude of the near-bore permeability changes observed in several nonisothermal injection tests conducted at the Los Azufres Geothermal Field. In order to ...
The five thermal-hydraulic concepts chosen for conceptual study of advanced PWR systems have been studied as follows: (1) Critical Heat Flux in passive PWR Conditions: review of previous works (various of correlations, analysis of parametric trends) on CHF, assessment and improvement of CHF prediction models for round tubes, development of the prediction model on bundle CHF with considering the correction factor calculated from the tube data base, design and construction of the intermediate-pressure CHF experimental loop, extension of CHF data base by performing the experiments at low-flow, and low-quality conditions (2) Passive Cooling Concepts for Concrete Containment Systems: Selection of the external condenser by comparing and reviewing between passive cooling concepts for concrete containment system concepts, survey and review of previous studies (theoretical mechanism of condensation heat transfer and effect of non-condensable gases) on the condensation ...
MnO2 in pyrolusite can react with SO2 in flue gas and obtain by-product MnSO4 x H2O. A pilot scale jet bubbling reactor was applied in this work. Different factorsaffecting both SO2 absorption efficiency and Mn2+ extraction rate have been investigated, these factors include temperature of inlet gas flue, ration of liquid/solid mass flow rate (L/S), pyrolusite grade, and SO2 concentration in the inlet flue gas. In the meantime, the procedure of purification of absorption liquid was also discussed. Experiment results indicated that the increase of temperature from 30 to 70 K caused the increase of SO2 absorption efficiency from 81.4% to 91.2%. And when SO2 concentration in the inlet flue gas increased from 500 to 3000 ppm, SO2 absorption efficiency and Mn2+ extraction rate decreased from 98.1% to 82.2% and from 82.8% to 61.7%, respectively. The content of MnO2 in pyrolusite had a neglectable effect on SO2 absorption ...
Calibration-Free Laser-Induced Breakdown Spectroscopy (CF-LIBS) has been proposed several years ago as an approach for quantitative analysis of Laser-Induced Breakdown Spectroscopy spectra. Recently developed refinement of the spectral processing method is described in the present work. Accurate quantitative results have been demonstrated for several metallic alloys. However, the degree of accuracy that can be achieved with Calibration-Free Laser-Induced Breakdown Spectroscopy analysis of generic samples still needs to be thoroughly investigated. The authors have undertaken a systematic study of errors and biasing factorsaffecting the calculation in the Calibration-Free Laser-Induced Breakdown Spectroscopy spectra processing. These factors may be classified in three main groups: 1) experimental aberrations (intensity fluctuations and inaccuracy in the correction for spectral efficiency of a detection system), 2) inaccuracy ...
Calibration-Free Laser-Induced Breakdown Spectroscopy (CF-LIBS) has been proposed several years ago as an approach for quantitative analysis of Laser-Induced Breakdown Spectroscopy spectra. Recently developed refinement of the spectral processing method is described in the present work. Accurate quantitative results have been demonstrated for several metallic alloys. However, the degree of accuracy that can be achieved with Calibration-Free Laser-Induced Breakdown Spectroscopy analysis of generic samples still needs to be thoroughly investigated. The authors have undertaken a systematic study of errors and biasing factorsaffecting the calculation in the Calibration-Free Laser-Induced Breakdown Spectroscopy spectra processing. These factors may be classified in three main groups: 1) experimental aberrations (intensity fluctuations and inaccuracy in the correction for spectral efficiency of a detection system), 2) inaccuracy ...
As both computer and mobile phone reach nearly ubiquity in the U.S. market, the slow uptake of mobile video, in contrast to the thriving usage of PC-based video, warrants a deeper understanding of user-oriented factors contributing to the two diffusion paths. Unlike the majority of existing diffusion research practices, the dissertation examines the differences between mobile and PC video diffusion patterns through the lenses of user-oriented influences in the user-technology relationship. Built upon the established adoption user group classification, the research is informed by the Uses and Gratification theory, the Social Technical theory, and the Technical Affordance perspective. These synergistic theoretical arguments share the recognition of the role of user in the dynamic, usually socially intertwined user-technology interactions. The key research questions that the dissertation sets out to answer include: Does the importance of ...
Surgical resection is the only curative treatment strategy for intrahepatic cholangiocarcinoma (CC). Therefore, accurate staging is essential for appropriate management of patients with CC. We assessed the usefulness of 2-["1"8F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) in the staging of CC. We undertook a retrospective review of FDG PET images in 21 patients (10 female, 11 male; mean age 57 years) diagnosed with CC. Ten patients had hilar CC and 11, peripheral CC. Patients underwent abdominal magnetic resonance imaging (MRI) (n=20) and computed tomography (CT) (n=12) for the evaluation of primary tumours, and chest radiography and whole-body bone scintigraphy for work-up of distant metastases. For semi-quantitative analysis, the maximum voxel standardised uptake value (SUV_m_a_x) was obtained from the primary tumour. All peripheral CCs showed intensely increased FDG uptake, and some demonstrated ring-shaped ...
The present investigation was aimed to assess the usefulness of biliary agents scintigraphy in the diagnosis of hepatocellular carcinoma (HCC) and to ascertain the relationship between the uptake of these agents and the degree of HCC differentiation. Forty-four patients with this hepatic cancer were included in the study. Liver scans were performed 20 min and 3 hr after the administration of 99mTc diisopropyliminodiacetic acid (DISIDA). DISIDA scintigraphy could not be assessed in six cases. In 16 (42%) out of the remaining 38 patients, the tumor exhibited equal or greater radioactivity uptake than the surrounding liver. In six out of these 16 patients, tumor uptake was apparent in the early and delayed hepatic scans, while in the other ten subjects radioactivity uptake by the HCC could only be detected in the 3-hr delayed scans. In the remaining 22 patients, HCC appeared as a cold area. Tumor location ...
Radioactive phosphorus (P-32) was injected to the chicken in the purpose of determination of the uptake and distribution, as related to sex and hour differences of the various organs of the body. 2..mu..Ci of P-32 were injected to each chicken and the distribution of P-32 was observed at 1 hr, 6 hrs, 12 hrs, 24 hrs and 48 hrs after injection. In this experiment 34 heads of chicken were used (30 chicken for P-32, 4 chicken for control group) and the results obtained as follows: 1. The uptake of P-32 per gram of various organ in g. mm, femur (1 hr), liver, femur, tibia (24 hrs) and tibia (48 hrs) exhibited higher in the male than the female. 2. The uptake of P-32 per gram of various organ in heart, kidney, ovary (1 hr), kidney, brain (24 hrs) and kidney (48 hrs) exhibited higher in the female than the male. 3. The uptake ratio of brain, spleen, g. mm and tibia were increased gradually by the 12 hrs after ...
Biosorption of cadmium (Cd), cobalt (Co), copper (Cu), nickel (Ni), lead (Pb), and zinc (Zn) by six fractions of particle sizes, ranging from 0.063 to 1.4 mm of dry marine algal biomass of Sargassum fluitans and Ascophyllum nodosum, is examined. Equilibrium metal uptake by larger particles was higher than that by smaller particles in the order of Pb > Cd > Cu > Co > Zn > Ni for both biomass types, with S. fluitans sorbing slightly more than A. nodosum. Uptakes of metals ranged from the highest, q{sub max} = 369 mg Pb/g (particle size 0.84-1.00 mm), to the low Zn and Ni uptakes, q{sub max} = 77 mg/g (size 0.84-1.00 mm) for S. fluitans. A. nodosum adsorbed metals in the range from q{sub max} = 287 mg Pg/g (particle size 0.84-1.00 mm) to q{sub max} = 73 mg Zn/g (particle size 0.84-1.00mm). Harder stipe fractions of S. fluitans demonstrated generally higher metal uptakes than the softer ...
The mechanism of cobalt uptake was investigated using cells of the giant alga Chara corallina in which it is possible to resolve separately uptake by the cell wall and actual influx across the cell membrane. The absorption of {sup 60}Co by Chara cells appeared to saturate within 2 h. but this was mainly due to rapid uptake into the cell wall which accounted for 87-92% of the total activity. Even after prolonged desorption most of the cell-associated {sup 60}Co was found on the cell wall. The intracellular distribution of absorbed {sup 60}Co was investigated by fractionating the cell into cytoplasm and vacuole. It was shown that {sup 60}Co influx to the vacuole occurs simultaneously with influx to the cytoplasm. The transported species appears to be Co{sup 2+} rather than the less charged Co(OH){sup +} or Co(O){sub 2}. {sup 60}Co influx is pH dependent (optimum pH 7-9), and is sensitive to some other divalent metals. Influx ...
The mechanism of cobalt uptake was investigated using cells of the giant alga Chara corallina in which it is possible to resolve separately uptake by the cell wall and actual influx across the cell membrane. The absorption of "6"0Co by Chara cells appeared to saturate within 2 h. but this was mainly due to rapid uptake into the cell wall which accounted for 87-92% of the total activity. Even after prolonged desorption most of the cell-associated "6"0Co was found on the cell wall. The intracellular distribution of absorbed "6"0Co was investigated by fractionating the cell into cytoplasm and vacuole. It was shown that "6"0Co influx to the vacuole occurs simultaneously with influx to the cytoplasm. The transported species appears to be Co"2"+ rather than the less charged Co(OH)"+ or Co(O)_2. "6"0Co influx is pH dependent (optimum pH 7-9), and is sensitive to some other divalent metals. Influx from solutions containing 1 #mu#M ...
Lipiodol CT is a important modality for the diagnosis of hepatocellular carcinoma and compared is usually performed at 2-3 week after Lipiodol injection. Therefore, we assessed and the diagnostic value and merits of immediate CT after chemoembolization from there of 2-3 week delayed Lipiodol CT. Thirty three cases of chemoembolization which were performed both immediate CT after chemoembolization and 2-3 week delayed Lipiodol CT were reviewed retrospectively. They were divided into four grades according to pattern of lipiodol uptake by three radiologists. The diagnostic value of immediate Lipiodol CT was compared to delayed Lipiodol CT. Grade 0 was two cases(3.0%) and Grade 1 was seven cases(21.2%). In the cases of Grade 2(23/33, 69.7%), tumor uptake could be dishing wished from parenchymal uptake of Lipiodol by its density and pattern, Tumor uptake showed dense and homogeneous pattern, but parenchymal ...
Previous work showed that the segl mutant of barley (Hordeum vulgare o Betzes) did not differ from normal Betzes in plant growth, photosynthesis, or fertility, but it produced only shrunken seeds regardless of pollen source. To determine whether defects in sucrose uptake or starch synthesis resulted in the shrunken condition, developing grains of Betzes and segl were cultured in (/sup 14/C)sucrose solutions after slicing transversely to expose the endosperm cavity and free space. In both young grains (before genotypes differed in dry weight) and older grains (17 days after anthesis, when segl grains were smaller than Betzes), sucrose uptake and starch synthesis were similar in both genotypes on a dry weight basis. To determine if sucrose was hydrolyzed during uptake, spikes of Betzes and segl were allowed to take up (fructose-U-/sup 14/C)sucrose 14 days after anthesis and the radioactivity of endosperm sugars was examined ...
Dust detection and control in real time, represent one of the most challenging problem in all those environments where fine and ultrafine airborne particulate solids products are present. The presence of such products can be linked to several factors, often directly related and influenced by the working-production actions performed. Independently from the causes generating dust, airborne contaminants are an occupational problem of increasing interest as they are related to a wide number of diseases. In particular, airborne dusts are well known to be associated with several classical occupational lung diseases, such as the pneumoconiosis, especially at high levels of exposure. Nowadays there is also an increasing interest in other dust related diseases, from the most serious as cancer and asthma, to those related with allergies or irritation and other illnesses, also occurring at lower levels of exposure. Among the different critical factors ...
The integrity of the RPV head and reactor internals was assessed by means of fluid-structural analyses using a coupled method to evaluate the water hammer phenomenon arising from high burnup fuel failure under RIA conditions. The fluid viscosity effect on the water column burst as well as the complex three-dimensional flow paths caused by a core shroud and standpipes were considered in this study. The three analysis scenarios were designed to investigate the above mentioned influential factors separately. In the first scenario, a two-dimensional axisymmetric reactor vessel model without any reactor internals was modeled to assess the influence of the fluid dynamics in the NSC RIA regulatory evaluation. This model has an actual RPV geometry and can be simply separated from other influential factors in order to concentrate only on investigation of the fluid viscosity effect. In the second scenario, a two-dimensional axisymmetric reactor vessel ...
The United States Department of Energy (U.S. DOE) has recently implemented a series of strategic initiatives to address long-term radiological surveillance needs at former U.S. nuclear test sites in the Marshall Islands. The plan is to engage local atoll communities in developing shared responsibilities for implementing radiation protection monitoring programs for resettled and resettling populations in the northern Marshall Islands. Using the pooled resources of the U.S. DOE and local atoll governments, individual radiological surveillance programs have been developed in whole body counting and plutonium urinalysis in order to accurately assess radiation doses resulting from the ingestion and uptake of fallout radionuclides contained in locally grown foods. Permanent whole body counting facilities have been established at three separate locations in the Marshall Islands including Rongelap Atoll (Figure 1). These facilities are operated and maintained by ...
A summary of the effects presented here is given in the table. The designation "factor present" implies that there is knowledge (from human or animal studies, or both) of a specific factor(s) present...Full Text Available
The language used by chronic benign pain patients to characterize their pain complaint was analyzed to determine the best predictor of psychiatric disturbance. Using the 78 adjectives provided by the McGill Pain Questionnaire, the number of affective descriptors used was the best predictor of psychiatric disturbance. Addition of sensory descriptors either to augment the total number of descriptors used (magnitude) or as a pattern of sensory greater than affective or sensory less than affective failed to increase predictive strength. PMID:6877847
Dysregulation of the alternative pathway of complement activation, caused by mutations or polymorphisms in the genes encoding factor H, membrane co-factor protein, factor I or factor B, is associated...Full Text Available
In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two...Full Text Available
Human Factor VIII/von Willebrand factor, purified by calcium citrate-cellulose chromatography and 4% agarose gel filtration was subjected to sodium dodecyl sulfate gel electrophoresis on gels containing...Full Text Available
The purpose of this paper is to investigate the influence of diabetic myocardial damage (suspected myocardial damage; SMD) diagnosed by [sup 201]Tl-SPECT and diabetic cardiac autonomic neuropathy (AN) on myocardial MIBG uptake in patients with NIDDM. Eighty-seven diabetic patients divided into four subgroups: 23 with SMD (+) AN (+); 19 with SMD (+) AN (-); 27 with SMD (-) AN (+); 18 with SMD (-) AN (-), and 10 controls were studied. Both planar and SPECT images were taken at 30 minutes (early) and 3 hours (delayed) after [sup 123]I-MIBG injection. The heart to mediastinum uptake ratio (H/M) and washout ratio of [sup 123]I-MIBG (WR) were obtained from both planar images. Similarly, the difference between the [sup 201]Tl image and the [sup 123]I-MIBG image in the total uptake score (TUS) was taken as the difference in the total uptake score ([Delta]TUS) representing cardiac sympathetic denervation without ...
A selected series of 24 patients with displaced medial femoral neck fracture, treated with closed reduction and osteosynthesis with cancellous bone screws (ASIF), were investigated. During an observation period of 6 to 26 months, serial hip joint scintigraphies were performed and compared with serial X-ray examinations. At the first scintigraphic examination performed on average 5-6 weeks after the fracture, two separate investigators found a decreased amount of activity or no activity in the femoral head of 10 and 8 patients, respectively. At the second scintigraphic examination performed on average 11.1 weeks after the fracture both investigators found no activity or a decreased amount of activity in 8 patients. This figure declined to 7 during the following period, because one patient with decreased activity was recorded as having normal activity 15 months after the fracture. These 7 patients all developed radiological signs of femoral head collapse on average 16.3 months after the ...
In this study we have compared brain uptake and blood clearance of /sup 99/Tcsup(m)-N-ethylpiperi-dinediamino dithiol (/sup 99/Tcsup(m)-NEP DADT), its 4-methylated derivative (/sup 99/Tcsup(m)-Me-NEP-DADT) and /sup 99/Tcsup(m)-hexamethyl-propylene-amine-oxime (/sup 99/Tcsup(m)-HMPAO) with that of N-isopropyl(/sup 123/I)iodoamphetamine (/sup 123/IAMP) in two dogs. Single photon emission tomography (SPECT) was employed to measure brain accumulation and retention of the four radiopharmaceuticals. Cerebral uptake of the /sup 99/Tcsup(m) complexes was lower than that of /sup 123/IAMP. There was considerable extracerebral activity in the dog's head, especially in the olfactory and snout regions. Because of slow blood clearance, /sup 99/Tcsup(m)-HMPAO showed high uptake in these regions. Brain uptake of /sup 99/Tcsup(m)-HMPAO reached a plateau 5 to 10 min after intravenous injection and remained ...
Most antibodies to factor VIII have recently been shown to react with discrete regions of the factor VIII light chain (within the C2 domain) and/or the factor VIII heavy chain (within the amino-terminal...Full Text Available
The R and D activities of the institute focused on two major projects, ``Molecular and cellular environmental toxicology``, and ``Biophysics of multi-cellular systems``. For assessment of health risks emanating from the uptake of heavy metal compounds, work performed under the first mentioned project studies the formation of allergy-inducing metabolic products from membrane lipids, and the effects of related cellular signaling processes. These studies are accompanied by an approach to quantify and classify the toxicity of environmental organometallic compounds. Another major task is research into the pathogenesis of lung disease induced by dusts, gases, and gas-dust mixtures and the liberation of inflammatory agents by immunological cell reactions (alveolar macrophages). Atomic force microscopy is the tool used to visualize the related dynamic changes in bronchial cells. Studies for detection of the localisation and structure of the Fe-Mo ...
Two experiments used the McGill Pain Questionnaire (MPQ) to examine the affective dimension of pain in patients whose pain was secondary to malignancy. In experiment I, segregating groups of cancer patients on the basis of extreme scores (high versus low) on the MPQ failed to produce segregation on independent measures of affect and infirmity. This outcome contrasts with earlier work with chronic benign pain patients. Experiment II compared cancer pain patients matched with benign pain patients on intensity of pain report on the affective dimension of the MPQ. Cancer pain patients reported a reliably higher affective loading to their pain. These data suggest that cancer pain patients employ different criteria than benign pain patients in selecting affective pain descriptors. Possible explanations for this difference are discussed. PMID:7070825
Two most important causes of portal hypertension are cirrhosis of liver and non-cirrhotic portal fibrosis (NCPF). The purpose of this study was to assess the scintigraphic appearances of "9"9"mTc sulfur colloid liver scan in differentiating liver cirrhosis from NCPF. Materials and Methods: Retrospective analysis records of 146 patients (91 male and 55 female) with diffuse hepatocellular disease was done for liver size, liver uptake, spleen size, spleen uptake, colloid shift to bone marrow and lungs. Results: Cirrhotic livers showed patchy and lower uptake than NCPF (59% vs. 20%, P-value 0.041). Spleen size was significantly increased in NCPF compared to cirrhosis (100% vs. 67%, P-value 0.0137). Significant colloid shift to bone marrow was noted in cirrhosis (84% vs. 7%, P-value<0.0001). Conclusion: "9"9"mTc sulfur colloid liver scan is a non-invasive procedure having a useful adjunctive role in clinical differentiation ...
Quantitative assessment of bone scintigraphy was performed in fifty-six patients with hip joint disease including femoral neck fracture, aseptic necrosis of the femoral head, traumatic dislocation of the hip, Perthes disease, and transient synovitis of the hip. In the static study, bone scintigraphy was obtained 3 hours after injection of sup(99m)Tc-MDP by gamma camera equipped with a computer and uptake ratios were calculated. In the dynamic study, bone scintigraphy was performed in one, 3 and 5 hours after injection of radionuclide. Femoral head uptake ratio was markedly decreased in osteonecrosis following femoral neck fracture and characteristically increased in aseptic necrosis of the femoral head but prolonged retention of sup(99m)Tc-MDP could be observed. Uptake ratios of epiphysis were decreased in Perthes disease but normal in transient synovitis of the hip. Static and dynamic study of bone scintigraphy may be ...
A 2-year follow-up regarding healing complications, such as redisplacement, nonunion, and segmental collapse of the femoral head, was performed in 306 patients operated on for femoral neck fracture and examined with /sup 99m/Technetium-MDP scintimetry within 2 weeks postoperatively. Scintimetric evaluation was performed by selecting regions of interest over the femoral head on the fracture side and the intact side and by comparing the uptake. A femoral head ratio fractured/intact side thus was obtained. Of 199 patients with an intact femoral head uptake (ratio less than or equal to 1.0), 181 showed no signs of healing complications at 2 years, whereas 18 had developed healing complications. Of 107 cases with a deficient femoral-head uptake (ratio < 1.0), 96 had developed healing complications within 2 years from the operation, while 11 cases had no signs of radiographic complications. We conclude that /sup 99m/Tc-MDP ...
A 2-year follow-up regarding healing complications, such as redisplacement, nonunion, and segmental collapse of the femoral head, was performed in 306 patients operated on for femoral neck fracture and examined with "9"9"mTechnetium-MDP scintimetry within 2 weeks postoperatively. Scintimetric evaluation was performed by selecting regions of interest over the femoral head on the fracture side and the intact side and by comparing the uptake. A femoral head ratio fractured/intact side thus was obtained. Of 199 patients with an intact femoral head uptake (ratio #<=# 1.0), 181 showed no signs of healing complications at 2 years, whereas 18 had developed healing complications. Of 107 cases with a deficient femoral-head uptake (ratio < 1.0), 96 had developed healing complications within 2 years from the operation, while 11 cases had no signs of radiographic complications. We conclude that "9"9"mTc-MDP scintimetry performed ...
The interest in radioiodinated diamines stems from their similarity to /sup 125/I-HIPDM and to the 1-dialkvlamino-acyl-4-phenylpiperazines that the authors have previously examined as potential brain imaging agents. In this study they converted the 1-(dialkylaminoacyl)-4-phenylpiperazines to their corresponding 1-(dialkylaminoacyl) analogs via reduction with diborane in THF. Radioiodination at the no-carrier-added level with Na/sup 125/I and chloramine-T gave the final compounds, after chromatographic separation, in 30-50% yields. The tissue distributions were determined in rats at 0.25, and 4 hrs after an i.v. injection of the radiochemical. The results indicated that all of the agents were readily extracted by the brain (1.5-2.5% ID) with brain to blood ratios >20. The structure-distribution relationships for this series were, however, decidedly different from the aminoacyl compounds in that morpholino-derivatives had better uptake and retention than the ...
The interest in radioiodinated diamines stems from their similarity to /sup 125/I-HIPDM and to the 1-dialkvlamino-acyl-4-phenylpiperazines that the authors have previously examined as potential brain imaging agents. In this study they converted the 1-(dialkylaminoacyl)-4-phenylpiperazines to their corresponding 1-(dialkylaminoacyl) analogs via reduction with diborane in THF. Radioiodination at the no-carrier-added level with Na/sup 125/I and chloramine-T gave the final compounds, after chromatographic separation, in 30-50% yields. The tissue distributions were determined in rats at 0.25, and 4 hrs after an i.v. injection of the radiochemical. The results indicated that all of the agents were readily extracted by the brain (1.5-2.5% ID) with brain to blood ratios >20. The structure-distribution relationships for this series were, however, decidedly different from the aminoacyl compounds in that morpholino-derivatives had better uptake and retention than the ...
In developing new Tc-99m brain perfusion imaging agents for SPECT, a series of BAT (bis-aminoethanethiol) derivatives was prepared. These N/sub 2/S/sub 2/ ligands formed stable and neutral complexes with reduced Tc-99m, either by Sn(II)-PPi or sodium borohydride reduction. The purity of the Tc-99m complexes was >95% (HPLC reverse-phase column, acetonitrile: pH 7.0 buffer, 85:15). The biodistribution in rats was evaluated using I-125 iodoantipyrine (IAP), a free diffusible tracer, as the internal reference. Compounds with a free hydroxyl group (I and IV) showed lower brain uptake, inspite of high P.C.; this may be related to in vivo instability of the complexes. High initial brain uptake was observed for three compounds (II, III and V), however, only compound V (P.C.=384) showed significant brain retention. Planar imaging with compound V in a monkey demonstrated that the compound localized in brain and the retention time was T/sub 1/2/=35 ...
In developing new Tc-99m brain perfusion imaging agents for SPECT, a series of BAT (bis-aminoethanethiol) derivatives was prepared. These N/sub 2/S/sub 2/ ligands formed stable and neutral complexes with reduced Tc-99m, either by Sn(II)-PPi or sodium borohydride reduction. The purity of the Tc-99m complexes was >95% (HPLC reverse-phase column, acetonitrile: pH 7.0 buffer, 85:15). The biodistribution in rats was evaluated using I-125 iodoantipyrine (IAP), a free diffusible tracer, as the internal reference. Compounds with a free hydroxyl group (I and IV) showed lower brain uptake, inspite of high P.C.; this may be related to in vivo instability of the complexes. High initial brain uptake was observed for three compounds (II, III and V), however, only compound V (P.C.=384) showed significant brain retention. Planar imaging with compound V in a monkey demonstrated that the compound localized in brain and the retention time was T/sub 1/2/=35 ...
Cell-penetrating peptides (CPPs) are useful tools for the delivery of hydrophilic bioactive molecules, such as peptides, proteins, and oligonucleotides, across the cell membrane. To realize the delivery of therapeutic macromolecules by CPPs, the CPPs are required to show resistance to protease and no cytotoxicity. In order to produce potent non-toxic and protease-resistant CPPs with high cellular uptake, we designed an amphipathic helix peptide using ?-aminoisobutyric acid (Aib, U) and named it MAP(Aib). In the MAP(Aib) molecule, five Aib residues are aligned on the hydrophobic face of the helix and five lysine (K) residues are aligned on the hydrophilic face. MAP(Aib) showed potent resistance to trypsin and pronase compared with MAP, an amphipathic helix peptide formed by usual amino acids. Fluorescein-labeled MAP(Aib) efficiently traversed the A549 cell membrane, diffusing into the cytoplasm and slightly into the nucleus without exerting any cytotoxicity. In ...
The CASTOC project addresses environmentally assisted cracking (EAC) phenomena in low alloy steels used for pressure boundary components in both Western type boiling water reactors (BWR) and Russian type pressurised water reactors (VVER). It comprises the four work packages (WP): inter-laboratory comparison test (WP1); EAC behaviour under static load (WP2), EAC behaviour under cyclic load and load transients (WP3); evaluation of the results with regard to their relevance for components in practice (WP4). The use of sophisticated test facilities and measurement techniques for the on-line detection of crack advances have provided a more detailed understanding of the mechanisms of environmentally assisted cracking and provided quantitative data of crack growth rates as a function of loading events and time, respectively. The effect of several major parameters controlling EAC was investigated with particular emphasis on the transferability of the results to components in service. The ...
This thesis describes the analysis of the semileptonic decay D{sup 0} {yields} {bar K}{sup 0} {pi}{sup -} {mu}{sup +}{nu} using FOCUS data. FOCUS is a fixed target experiment at Fermilab that studies the physics of the charm quark. Particles containing charm are produced by photon-gluon fusion from the collision of a photon beam on a BeO target. The experiment is characterized by excellent vertex resolution and particle identification. The spectrometer consists of three systems for track reconstruction (two silicon systems and one multiwire proportional chamber system) and two magnets of opposite polarity. The polarity of the magnet is such that the events of e{sup +}e{sup -} pairs produced in the target (which constitutes the main background) travel through a central opening in the detectors without interactions. Particle momentum is measured from the deflection angle in the magnets. Three multicell Cerenkov counters are used for charged particle identification (for e, {pi}, K, and ...