Science.gov (United States)

The ratio of the proton's electric to magnetic form factor, G{sub E}/G{sub M}, can be extracted in elastic electron-proton scattering by measuring cross sections, beam-target asymmetry, or recoil polarization. Separate determinations of G{sub E}/G{sub M} by cross sections and recoil polarization observables disagree for Q{sup 2}>1 (GeV/c){sup 2}. Measurement by a third technique might uncover an unknown systematic error in either of the previous measurements. The beam-target asymmetry has been measured for elastic electron-proton scattering at Q{sup 2} = 1.51 (GeV/c){sup 2} for target spin orientation aligned perpendicular to the beam momentum direction. This is the largest Q{sup 2} at which G{sub E}/G{sub M} has been determined by a beam-target asymmetry experiment. The result, {mu}G{sub E}/G{sub M}=0.884{+-}0.027{+-}0.029, is compared to previous world data.

International Nuclear Information System (INIS)

We present results of an investigation to study CP violation in the Higgs sector in tt-bar production at a #gamma##gamma#-collider, via the process #gamma##gamma# #-># #phi# #-># tt-bar where the #phi# is a scalar with indeterminate CP parity. The study is performed in a model independent way parametrising the CP violating couplings in terms of six form factors #left brace#R(S_#gamma#), T(S_#gamma#), R(P_#gamma#), T(P_#gamma#), S_t, P_t#right brace#. The CP violation is reflected in the polarisation asymmetry of the produced top quark. We use the angular distribution of the decay lepton from t/t-bar as a diagnostic of this polarisation asymmetry and hence of the CP mixing, after showing that the asymmetries in the angular distribution are independent of any CP violation in the tbW vertex. We construct combined asymmetries in the initial state lepton (photon) polarization and ...

UK PubMed Central (United Kingdom)

BackgroundThe mammalian FoxO transcription factors function to regulate diverse physiological processes. Emerging evidence that both BDNF and lithium suppress FoxO...Full Text Available

Science.gov (United States)

We have measured the transverse asymmetry A{sub T{sup '}} in the quasielastic {sup 3}He-vector(e-vector,e{sup '}) process with high precision at Q{sup 2} values from 0.1 to 0.6 (GeV/c){sup 2}. The neutron magnetic form factor G{sub M}{sup n} was extracted at Q{sup 2} values of 0.1 and 0.2 (GeV/c){sup 2} using a nonrelativistic Faddeev calculation which includes both final-state interactions (FSI) and meson-exchange currents (MEC). Theoretical uncertainties due to the FSI and MEC effects were constrained with a precision measurement of the spin-dependent asymmetry in the threshold region of {sup 3}He-vector(e-vector,e{sup '}). We also extracted the neutron magnetic form factor G{sub M}{sup n} at Q{sup 2} values of 0.3 to 0.6 (GeV/c){sup 2} based on plane wave impulse approximation calculations.

UK PubMed Central (United Kingdom)

The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site. Elk-1 is associated with...Full Text Available

International Nuclear Information System (INIS)

The sensitivity of the primary circuit material was examined at the Mochovce and Dukovany NPPs. No significant sensitivity of the base material or the weld metal to the initiation of corrosion cracking was observed. Thermal aging was found to accelerate significantly the corrosion fatigue kinetics in the material of the heat affected zone. The threshold values of the double amplitudes of the stress intensity factor were below 8 MPa/m"2 for the materials examined, with a cycle asymmetry coefficient of 0.65. The tests revealed no appreciable sensitivity to general corrosion, pitting, or intergranular corrosion. (J.B.). 7 tabs., 26 figs., 11 refs.

UK PubMed Central (United Kingdom)

Although acetylated α-tubulin is known to be a marker of stable microtubules in neurons, precise factors that regulate α-tubulin acetylation are, to date, largely unknown. Therefore,...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The polarization of extracted SATURNE II proton beam as a function of different ion source configurations was studied. Two distinct experiments were necessary for this purpose. In the first one, the left-right instrumental asymmetry of the beam polarimeter was determined using an unpolarized beam. In the second one this correction factor was applied to asymmetries measured with the beam from the polarized ion source in all polarization states. The measurements were carried out at the proton beam kinetic energy 0.80 GeV, where the pp-elastic scattering analyzing power is near its maximum. The results confirmed that the two so-called ``unpolarized states`` of the source were polarized to several percent, whereas the absolute values of the beam polarizations in the so-called ``polarized states`` were equal and opposite. It was observed that the hexapole lens of the ion source produced beam polarization in the absence of any ...

UK PubMed Central (United Kingdom)

Hypoxia inducible factor-1 (HIF-1) promotes tumor cell adaptation to microenvironmental stress. HIF-1 is up-regulated in irradiated tumors and serves as a promising target for radiosensitization....Full Text Available

UK PubMed Central (United Kingdom)

Cellular hypertrophy is regulated by coordinated pro- and antigrowth machineries. Foxo transcription factors initiate an atrophy-related gene program to counter hypertrophic growth. This study was designed...Full Text Available

UK PubMed Central (United Kingdom)

α₁-Fetoprotein transcription factor (FTF), also known as liver receptor homolog 1 (LRH-1) is highly expressed in liver and intestine, where it is implicated in the regulation...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Possible explanations are given for the observed asymmetry of the analyzing power in several (rho,..pi../sup -/) reactions.

British Library Electronic Table of Contents (United Kingdom)

Glucagon plays critical roles in regulating glucose homeostasis, mainly by counteracting the effects of insulin. Consequently, the dysregulated glucagon secretion that is evident in type 2 diabetes has significant implications in the pathophysiology of the disease. Glucagon secretion from pancreatic -cells has been suggested to be modulated by blood glucose, signals from the nervous system and endocrine components. In addition to these regulators, intraislet factors acting in a paracrine manner from neighbouring -cells are emerging as central modulator(s) of -cell biology. One of the most important of these paracrine factors, insulin, modulates glucagon secretion. Indeed, the -cell-specific insulin receptor knockout (IRKO) mouse manifests hypersecretion of glucagon in the postprandial stag...

International Nuclear Information System (INIS)

Redd1, a recently discovered stress-response gene, is regulated by hypoxia via hypoxia-inducible factor 1 (HIF-1) and by DNA damage via p53/p63; however, the signaling pathway by which its expression is induced by hypoxia has not been elucidated. We demonstrated that the up-regulation of Redd1 transcription by hypoxia and high cell density (HCD) depends on cooperation between Sp1 and HIF-1#alpha# downstream of the PI3K/Akt pathway.

Science.gov (United States)

... time, sucrase activity, a marker of intestinal epithelium (Matsushita, 1983) was observed in epithelial cells with CdxA ... PubMed, CSAIshii, Y., K. Fukuda, H. Saiga, S. Matsushita, and S. Yasugi. 1997. E...

UK PubMed Central (United Kingdom)

CBP and its paralog p300 are histone acetyl transferases that regulate gene expression by interacting with multiple transcription factors via specialized domains. The structure...Full Text Available

UK PubMed Central (United Kingdom)

The processes regulating telomere function have major impacts on fundamental issues in human cancer biology. First, active telomere maintenance is almost always required for full oncogenic transformation...Full Text Available

UK PubMed Central (United Kingdom)

A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for...Full Text Available

UK PubMed Central (United Kingdom)

Dissecting the genes involved in complex traits can be confounded by multiple factors, including extensive epistatic interactions among genes, the involvement of epigenetic regulators, and the variable...Full Text Available

UK PubMed Central (United Kingdom)

Skeletal formation is an essential and intricately regulated part of vertebrate development. Humans and mice deficient in Growth and Differentiation Factor 6 (Gdf6) have numerous...Full Text Available

UK PubMed Central (United Kingdom)

BACKGROUND: Mitochondrial changes have been described in muscle tissue in acquired hypothyroidism. Among the molecular mechanisms by which thyroid hormones regulate expression of nuclear genes encoding...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe transcription factor Pax6 is essential for the development of the central nervous system and it exerts its multiple functions by regulating the expression of downstream...Full Text Available

UK PubMed Central (United Kingdom)

Mechanisms regulating sexual differentiation of the zebra finch song system appear to include both genetic and hormonal factors. Sorting Nexin 2 (SNX2), which is involved in trafficking proteins...Full Text Available

UK PubMed Central (United Kingdom)

Psychopathic individuals are generally unresponsive to motivational and emotional cues that facilitate behavioral regulation. A putative mechanism for this deficiency is Gray’s (1971)...Full Text Available

UK PubMed Central (United Kingdom)

The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundObesity is one of the principal causative factors involved in the development of metabolic syndrome. AMP-activated protein kinase (AMPK) is an energy sensor that regulates...Full Text Available

UK PubMed Central (United Kingdom)

sFlt-1 (soluble Flt-1) potently inhibits angiogenesis by binding extracellularly to VEGF (vascular endothelial growth factor). In the present paper, we report that hypoxia down-regulates sFlt-1 expression...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Abstract Plant pathogenic bacteria of the genus Xanthomonas cause a variety of diseases in economically important monocotyledonous and dicotyledonous crop plants worldwide. Successful infection and bacterial multiplication in the host tissue often depend on the virulence factors secreted including adhesins, polysaccharides, LPS and degradative enzymes. One of the key pathogenicity factors is the type III secretion system, which injects effector proteins into the host cell cytosol to manipulate plant cellular processes such as basal defense to the benefit of the pathogen. The coordinated expression of bacterial virulence factors is orchestrated by quorum-sensing pathways, multiple two-component systems and transcriptional regulators such as Clp, Zur, FhrR, HrpX and HpaR. Furthermore, virule...

CERN Document Server

Light vector meson leptoproduction is analyzed on the basis of the generalized parton distributions. Our results on the cross section and spin effects are in good agrement with experiment at HERA, COMPASS and HERMES energies. Predictions for $A_{UT}$ asymmetry for various reactions are presented.

CERN Document Server

Utilizing form factors calculated within the light-cone sum rules, we have evaluated the decay branching ratios of $B_s\\to \\phi\\gamma$ and $B_s\\to \\phi \\ell^+\\ell^-$ in a single universal extra dimension model (UED), which is viewed as one of the alternative theories beyond the standard model (SM). For the decay $B_s \\to \\phi \\ell^+\\ell^-$, the dilepton invariant mass spectra, the forward-backward asymmetry, and double lepton polarization are also calculated. For each case, we compared the obtained results with predictions of the SM. In lower values of the compactification factor 1/R, the only parameter in this model, we see the considerable discrepancy between the UED and SM models. However, when 1/R increases, the results of UED tend to diminish and at $1/R = 1000 \\mathrm{GeV}$, two models have approximately the same predictions. Compared with data from CDF of $B_s \\to \\phi \\mu^+ \\mu^-$, the 1/R tends to ...

Energy Technology Data Exchange (ETDEWEB)

Using the Relativistic Mean Field Theory (RMF) it is shown that different proton fraction which is directly connected with the neutron excess and with the asymmetry of the system affects proto-neutron stars parameters and changes their composition. The obtained form of the equation of state allows to construct the mass-radius relations and shows that the increasing asymmetry creates more compact stars. The inclusion of {delta} meson together with nonlinear vector meson interaction terms and magnetic field make this effect even stronger.

UK PubMed Central (United Kingdom)

RIN proteins serve as guanine nucleotide exchange factors for Rab5a. They are characterized by the presence of a RIN homology domain and a C-terminal Vps9 domain. Currently three family members have...Full Text Available

UK PubMed Central (United Kingdom)

The expression status of the estrogen receptor alpha (ERα) and that of the epidermal growth factor receptor Her-2/neu frequently correlate inversely in breast cancers. While ERα-dependent...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Depth dose distributions for protons in the energy range from 2 to 600 MeV have been calculated by Monte Carlo and analytical methods. The dependence on energy of Maximum Dose Equivalent (MDE), quality factor and isotropic factor recommended for practical use are presented. The problems connected with regulation of maximum permissible proton fluxes are discussed. (author).

UK PubMed Central (United Kingdom)

Arf GTPases control vesicle formation from different intracellular membranes and are regulated by Arf guanine nucleotide exchange factors (GEFs). Outside of their conserved catalytic domains, known...Full Text Available

CERN Document Server

One of the most interesting discoveries of the X-ray Telescope and EUV Imaging Spectrometer (EIS) on board the Hinode solar observatory is the presence of persistent high temperature high speed outflows from the edges of active regions. Measurements by EIS indicate that the outflows reach velocities of 50 km/s with spectral line asymmetries approaching 200 km/s. It has been suggested that these outflows may lie on open field lines that connect to the heliosphere, and that they could potentially be a significant source of the slow speed solar wind. A direct link has been difficult to establish, however. In this letter, we use EIS measurements of spectral line intensities that are sensitive to changes in the relative abundance of Si and S as a result of the first ionization potential (FIP) effect, to measure the chemical composition in the outflow regions of AR 10978 over a period of 5 days in December 2007. We find that Si is always enhanced over S by a ...

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This document includes the following topics: Background; Data Collection; Scope/Applicability of the Proposed Regulation; Description of the Industry; Industry Subcategorization; Pollutants of Concern for the Centralized Waste Treatment Industry; Pollutants Selected for Regulation; Wastewater Treatment Technologies; Regulatory Options Considered and Selected for Basis of Regulation; Long-Term Averages, Variability Factors, and Limitations and Standards; Cost of Treatment Technologies; Pollutant Loading and Removal Estimates; Non-Water Quality Impacts; Implementation; Analytical Methods and Baseline Values; List of Definitions; List of Acronyms; Appendix A--Pollutant Groups; Appendix B--Listing of Characerization Data From Non-Hazardous Oils Facilities; Appendix C--Listing of Daily Influent and Effluent Measuements; Appendix D--Facility-Specific Compliance Costs; Appendix E--Attachements to Chapter 10; ...

British Library Electronic Table of Contents (United Kingdom)

Possible factors regulating phytoplankton variability in the Arabian (Persian) Gulf were analyzed on the basis of satellite observations and meteorological data (1997-2009), including remotely-sensed chlorophyll a concentration (CHL), sea surface temperature, wind, solar radiation, precipitation, and aerosols. Shallow waters of northwestern Gulf influenced by Shatt Al-Arab River discharge were more productive than open Gulf waters, although seasonal CHL patterns in this and other shallow regions looked unrealistic likely because the CHL signal was obscured by bottom reflection. Therefore our further analyses focused on the open Gulf waters, which show a subtropical seasonal CHL cycle with maximum in winter and minimum in spring-summer. This cycle, however, was decoupled from the seasonal e...

International Nuclear Information System (INIS)

Possible anomalous top-quark couplings induced by SU(2)xU(1) gauge-invariant dimension-6 effective operators were studied in the process of ttbar productions and decays at polarized #gamma##gamma# colliders. Two CP-violating asymmetries, a linear-polarization asymmetry and a circular-polarization asymmetry, were computed including both non-standard ttbar#gamma# and #gamma##gamma#H couplings. An optimal-observable analysis for the process #gamma##gamma##->#ttbar#->#l"#+-# was performed in order to estimate the precision for determination of all relevant non-standard couplings, including the anomalous tbW coupling.

British Library Electronic Table of Contents (United Kingdom)

A study of elliptical flow is carried out for different mass asymmetries of colliding nuclei using the reactions of Formula Not Shown ( Formula Not Shown ), Formula Not Shown ( Formula Not Shown ) and Formula Not Shown ( Formula Not Shown ). The present reactions are simulated at incident energies between 50 and 250 MeV/nucleon within the framework of isospin-dependent quantum molecular dynamics model. For the present analysis, total mass of colliding pairs is kept fixed and mass asymmetry is varied between 0.3 and 0.7. The elliptical flow shows a transition from in-plane to out-of-plane in the mid rapidity region with incident energy. The transition energy is found to increase with the mass asymmetry for light charged particles. A good agreement is obtained with experimental measurements.

Science.gov (United States)

Endoreduplication represents a cell cycle variant during which multiple rounds of DNA replication occur without subsequent chromosome separation and cytokinesis, resulting into a cellular increase of the DNA content. Although the DNA ploidy level of cells is controlled by external stimuli such as light, currently limited knowledge is available on how environmental signals regulate the endoreduplication cycle at the molecular level. Previously, we have demonstrated that the conversion from the mitotic cell cycle into an endoreduplication cycle is mediated by the atypical E2F transcription factor DEL1 that operates as a repressor of endocycle onset. Here, we identified DEL1 as a transcriptional target of the classical E2Fb and E2Fc transcription factors that antagonistically control DEL1 transcript levels through competition for a single E2F cis-acting binding site. Correspondingly with the reported opposite effect of light ...

UK PubMed Central (United Kingdom)

The biological actions of juvenile hormones are well studied; they regulate almost all aspects of an insect’s life. However, the molecular actions of these hormones are not well understood....Full Text Available

UK PubMed Central (United Kingdom)

Autophagy is a regulated catabolic process triggered in cells deprived of nutrients or growth factors that govern nutrient uptake. Here we report that autophagy is induced by cetuximab, a therapeutic...Full Text Available

UK PubMed Central (United Kingdom)

Sterol regulatory element-binding protein (SREBP)-1 is a key transcription factor for the regulation of lipogenic enzyme genes in the liver. Polyunsaturated fatty acids (PUFA) selectively suppress hepatic...Full Text Available

UK PubMed Central (United Kingdom)

Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, Nrp1 null embryos display vascular...Full Text Available

UK PubMed Central (United Kingdom)

The capacity of bones to adjust their mass and architecture to withstand the loads of everyday activity derives from the ability of their resident cells to respond appropriately to the strains engendered....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundEstrogen receptors alpha (ERα) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype...Full Text Available

UK PubMed Central (United Kingdom)

Metastatic disease is a primary cause of cancer-related death, and factors governing tumor cell metastasis have not been fully elucidated. Here, we address this question by using tumor cell lines derived...Full Text Available

UK PubMed Central (United Kingdom)

Angiotensin II (Ang II) is a key proapoptotic factor in fibrotic tissue diseases. However, the mechanism of Ang-II-induced cell death in endothelial cells has not been previously elucidated....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The first part of a systematic investigation is presented of surface treatments affecting the fatigue behavior of smooth and notched quenched and tempered (Q and T) specimens made of a B-Mn SS2131 ({approx}AISI 15B21H) steel. In this part, the effects of plasma nitriding (nitriding temperature=480 C, time=24 h) on the fatigue strength and notch sensitivity were investigated. Constant stress amplitude plane reversed bending fatigue tests (R=-1) at 47 Hz were conducted using cylindrical plasma nitriding (PN) and Q and T steel specimens with K{sub t}=1.05 and 1.7. The compound layer was found to consists of {epsilon}-phase and {gamma}`-phase. S-N curves show that plasma nitriding improves the fatigue limit by 53 and 115% of Q and T smooth and notched specimens, respectively. The fatigue strength of smooth specimens is improved through the whole fatigue life but only for long fatigue lives for notched specimens. Plasma nitriding reverses the low notch sensitivity (at short lives) and high ...

International Nuclear Information System (INIS)

Neuron-restrictive silencer factor (NRSF) binds its consensus element to repress the transcription of various genes. The dominant-negative form (dnNRSF) has a hypertrophic effect on cardiogenesis through an unidentified mechanism. We examined the involvement of transient receptor potential (TRP) channel proteins, using transgenic mice overexpressing dnNRSF (dnNRSF mice). Electrophoretic mobility-shift assays revealed an interaction between NRSF and a neuron-restrictive silencer element-like sequence in intron 4 of TRPC1 genomic DNA. According to RT-PCR and Western analyses, TRPC1 was up-regulated in dnNRSF mouse heart. Transient overexpression of TRPC1 in HEK 293T cells increased the activity of the nuclear factor in activated T cells (NFAT) promoter and stimulated store-operated Ca"2"+ channel (SOCC)-mediated Ca"2"+ entry. Transfection of TRPC1 into primary cardiomyocytes increased NFAT activity, indicating a major role ...

Science.gov (United States)

Vascular endothelial growth factor (VEGF) is a mitogen that is critically involved in vasculogenesis, angiogenesis, and hematopoiesis. However, what and how transcription factors participate in the regulation of vegf gene expression are not fully understood. Here we report the cloning and sequencing of the zebrafish vegf promoter which revealed that the promoter contains a number of bone morphogenetic protein (BMP)-activated Smad binding elements (SBE), implicating Smad1 and Smad5 in the regulation of BMP-induced expression of vegf. Electrophoretic mobility shift assays of adding recombinant Smad proteins to the SBE-containing DNA oligonucleotides that represent portions of zebrafish vegf promoter resulted in mobility shift of the oligonucleotides. These changes demonstrate potential interactions between Smad1/5 and the vegf promoter. Reporter activity assays using the wild-type or SBE-deleted vegf ...

Energy Technology Data Exchange (ETDEWEB)

When the transmission line is very long or the generator is operated at a power factor nearly equal to 1.0, the machine regulated by an automatic voltage regulator (AVR) cannot be operated stably due to poor dynamic stability. To overcome this difficulty, the so called power system stabilizer (PSS) is very useful, in that output power or rotor speed of the generator is used as a feedback signal. The primary obective of the PSS is to damp the swing of the generator as quickly as possible. A method is proposed for designing PSS which yields a given eigenvalue. In the second method, the use of a Heffron-Phillips model is discussed. Next, a detailed procedure for the proposed design method is presented. A generalized method of a PSS design based on Park's equation and matrix operation is proposed.

Energy Technology Data Exchange (ETDEWEB)

Possible anomalous top-quark couplings induced by SU(2)xU(1) gauge-invariant dimension-6 effective operators were studied in the process of ttbar productions and decays at polarized {gamma}{gamma} colliders. Two CP-violating asymmetries, a linear-polarization asymmetry and a circular-polarization asymmetry, were computed including both non-standard ttbar{gamma} and {gamma}{gamma}H couplings. An optimal-observable analysis for the process {gamma}{gamma}{yields}ttbar{yields}l{sup {+-}} was performed in order to estimate the precision for determination of all relevant non-standard couplings, including the anomalous tbW coupling.

British Library Electronic Table of Contents (United Kingdom)

Most active pharmaceutical ingredients (API) exhibit particle size distributions with some degrees of asymmetry deviating from log-normality. A new log-skew-normal (L-S-N) distribution model is proposed for a systematic comparison of the asymmetry effect on content uniformity. The new model originated from the S-N model used by Azzalini gives a close approximation to real API particle size distribution. Monte-Carlo method was employed to simulate the dosage potency distribution. A high risk of over potency is uncovered when either the dose is low or API particle size distribution is positively skewed. This is due to the formation of pseudo heavy tail in potency distribution that decays slower than exponentially. Nomographs of API particle size versus dosage strength were constructed with a...

Energy Technology Data Exchange (ETDEWEB)

The paper evaluates standardization of regulations on safety of electrical equipment for underground coal mines in the USSR. Factors increasing hazards of electrical failures of equipment in underground coal mines are analyzed: reduced lighting, increased humidity and dusts, damage caused by falling rocks or damage during haulage in underground workings, installation of electrical equipment in places easily accessible to untrained personnel. Standards on safety of electrical equipment for underground coal mining valid in the USSR are reviewed: the PIRNEh regulations on production of electrical equipment for coal mines developed by the VNIIVEh Institute, and the GOST national standards. International cooperation within the COMECON on safety of mining electrical equipment (the Interelectro Committee of the COMECON) is described. Certification of electrical equipment for coal mines is discussed on the example of electrical ...

British Library Electronic Table of Contents (United Kingdom)

CD44, a transmembrane receptor for hyaluronic acid, is implicated in various adhesion-dependent cellular processes, including cell migration, tumor cell metastasis and invasion. Recent studies demonstrated that CD44 expressed in cancer cells can be proteolytically cleaved at the ectodomain by membrane type 1-matrix metalloproteinase (MT1-MMP) to form soluble CD44 and that CD44 cleavage plays a critical role in cancer cell migration. Here, we show that transforming growth factor-b (TGF-b), a multifunctional cytokine involved in cell proliferation, differentiation, migration and pathological processes, induces MT1-MMP expression in MDA-MB-435s cells. TGF-b-induced MT1-MMP expression was blocked by the specific extracellular regulated kinase-1/2 (ERK1/2) inhibitor PD98059 and the specific pho...

Energy Technology Data Exchange (ETDEWEB)

Radiation protection programs for workers are based, in the United States, on a hierarchy of limitations stemming from Federal guidance approved by the President. This guidance, which consists of principles, policies, and numerical primary guides, is used by Federal agencies as the basis for developing and implementing their own regulatory standards. The primary guides are usually expressed in terms of limiting doses to workers. The protection of workers against taking radioactive materials into the body, however, is accomplished largely through the use of regulations based on derived guides expressed in terms of quantities or concentrations of radionuclides. The values of these derived guides are chosen so as to assure that workers in work environments that conform to them are unlikely to receive radiation doses that exceed the primary guides. The purpose of the present report is to set forth derived guides that are consistent with current Federal radiation ...

International Nuclear Information System (INIS)

This paper reports regulation of hypoxia inducible factor-1 ? (HIF-1 ?)in hepatoma cells by irradiation. Cobalt chloride (CoCl2), a chemical mimic agent for hypoxia research, was utilized to induce the stable expression of HIF-1 ? in HepG2 cells. The HepG2 cells were irradiated to different doses to observe the changes of HIF-1 ?. The level of intracellular reactive oxygen species (ROS) was assayed by fluorescent microscope and flow cytometry (FCM). The results showed that there were obvious changes in expression of HIF-1 ? after HepG2 cells exposed to radiation, and the changes were positively related with the irradiation dose from 1 Gy to 5 Gy. Moreover, contents of incellular ROS were negatively correlated with above levels of HIF-1 ? from 1 Gy to 3 Gy. The results indicate that irradiation may enhance hypoxic cells HIF-1 ?, and the reduction of intracellular ROS can contribute to the regulation of ionizing radiation on ...

Energy Technology Data Exchange (ETDEWEB)

A reliable source of specific criteria for recognizing a wetland, as defined for regulatory purposes would be valuable. In 1987 the Army Corps of Engineers developed a technical manual for identifying wetlands (1987 Wetlands Manual). An interagency manual (1989 Wetlands Manual) was later developed. This manual has been used to identify wetlands according to three evidentiary factors: vegetation, hydrology, and soil. This paper addresses the development of criteria to delineate wetlands, and describes some of the logic used by federal courts to uphold the limited constitutional use of the 1989 Wetlands Manual.

British Library Electronic Table of Contents (United Kingdom)

Purpose To study the activation and expression of vascular (aorta and small mesenteric arteries) potassium channels during septic shock with or without modulation of the NO pathway. Methods Septic shock was induced in rats by peritonitis. Selective inhibitors of vascular KATP (PNU-37883A) or BKCa [iberiotoxin (IbTX)] channels were used to demonstrate their involvement in vascular hyporeactivity. Vascular response to phenylephrine was measured on aorta and small mesenteric arteries mounted on a wire myograph. Vascular expression of potassium channels was studied by PCR and Western blot, in the presence or absence of 1400W, an inducible NO synthase (iNOS) inhibitor. Aortic activation of the transcriptional factor nuclear factor-kappaB (NF-?B) was assessed by electrophoretic mobility shift as...

British Library Electronic Table of Contents (United Kingdom)

The cAMP response element-binding protein (CREB) is a highly conserved transcription factor that integrates signaling through the cAMP-dependent protein kinase A (PKA) in many eukaryotes. PKA plays a critical role in Dictyostelium development but no CREB homologue has been identified in this system. Here we show that Dictyostelium utilizes a CREB-like protein, BzpF, to integrate PKA signaling during late development. bzpF^- mutants produce compromised spores, which are extremely unstable and germination defective. Previously, we have found that BzpF binds the canonical CRE motif in vitro. In this paper, we determined the DNA binding specificity of BzpF using protein binding microarray (PBM) and showed that the motif with the highest specificity is a CRE-like sequence. BzpF is necessary to ...

Science.gov (United States)

Background: Protein disulfide isomerase (PDI) controls platelet integrin function, tissue-factor (TF) activation, and concentrates at fibrin and thrombus formation sites of vascular injury. Objective: We investigated involvement of surface thiol isomerases and especially PDI, in thrombin-mediated thrombin amplification on human platelets. Methods/Results: Using a new developed thrombin-dependent platelet thrombin generation assay we observed that the feedback activation of thrombin generation on the platelet surface does not depend on TF, as anti-TF antibodies inhibiting TF-induced thrombin formation in platelet-depleted plasma had no effect compared to vehicle-treated controls. Feedback activation of thrombin generation in the presence of platelets was significantly diminished by membrane impermeant thiol blockers or by the thiol isomerase-inhibitors bacitracin and anti-PDI antibody RL90, respectively. Platelet thrombin formation depends on binding of coagulation ...

CERN Document Server

Recent studies have revealed a number of striking dependence patterns in high frequency stock price dynamics characterizing probabilistic interrelation between two consequent price increments x (push) and y (response) as described by the bivariate probability distribution P(x,y) [1,2,3,4]. There are two properties, the market mill asymmetries of P(x,y) and predictability due to nonzero z-shaped mean conditional response, that are of special importance. Main goal of the present paper is to put together a model reproducing both the z-shaped mean conditional response and the market mill asymmetry of P(x,y) with respect to the axis y=0. We develop a probabilistic model based on a multi-component ansatz for conditional distribution P(y|x) with push-dependent weights and means describing both properties. A relationship between the market mill asymmetry and predictability is discussed. A possible connection of the model to ...

Energy Technology Data Exchange (ETDEWEB)

Attacks by herbivorous insects reduce biomass production in willow plantations. The long-term goal of our research is to develop sustainable plant protection against these insect pests. Two lines of research are pursued. The first concentrates on identifying factors involved in the regulation of leaf-eating beetles. These insects vary in density among plantations, sometimes reaching outbreak levels resulting in complete defoliation. Mortality factors of eggs and larvae in plantations with low and high beetle densities have been investigated. The importance of plant resistance has also been investigated. The second line of research considers the mechanisms behind an earlier demonstrated resistance in certain willow clones against a gall midge. By using molecular techniques we have searched for markers of resistance. Promising results have been found concerning so called PR proteins; in particular chitinase seems to be ...

Energy Technology Data Exchange (ETDEWEB)

To study the regulation of adipose tissue lipoprotein lipase (LPL) in human adipocytes, omental adipose tissue was obtained from healthy subjects and digested in collagenase. The isolated adipocytes thus obtained were suspended in Medium 199 and cultured at 37 degrees C. Cell viability was demonstrated in adipocytes cultured for up to 72 h by constancy of cell number, cell size, trypan-blue exclusion, and specific /sup 125/I-insulin binding. In addition, chloroquine induced an increase in cell-associated /sup 125/I-insulin at 24, 48, and 72 h after preparation. Thus, isolated adipocytes retained their ability to bind, internalize, and degrade insulin. LPL was measured as activity secreted into the culture medium (CM), released from cells by heparin (HR), and extracted from cell digests. A broad range of heparin concentrations produced a prompt release of LPL from a rapidly replenishable pool of cellular activity. When cells were cultured in medium containing 10% ...

Science.gov (United States)

... (tb*it 06(M WfIio[td) Page 2. Asynchronous Digital Regulators Vernon Scott Ritchey, Ph.D. ... Page 3. ASYNCHRONOUS DIGITAL REGULATORS ...

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This report surveys the possibilities and restrictions of different construction materials for the purpose of the blades of a small stall regulated turbine. For example scaling up, material saving at decreasing of static or dynamic loads, comparisons of global costs based on prices per unit of weight, etc. For the mutual comparison of construction materials for turbine blades the starting point is a stall regulated horizontal axis turbine with a rotor diameter of 16 m and a tipvane speed of about 64 m/s. Short descriptions are given of the materials and of the applied production methods with the resulting blade geometry. The blade skins are dimensionized for storm loads after the optimalization of the blade geometry, needed for the design wind speed, is recorded. The resulting blade skins are mutually compared as for weight, mass inertia and bending stiffness. Also a comparison took place of the resulting reserve factors ...

International Nuclear Information System (INIS)

The predicted results of INDAC code were compared with measured "3H concentrations in air and pine-needle around the Wolsung site. The optimal sets of input data to INDAC were in addition selected by comparing the measured values with the predicted values of INDAC based on various conditions such as the release modes of effluents into the environment, the classification of wind classes, and the consideration of terrain. The predicted "3H concentrations in air and pine-needle were shown to have good agreement with measured values, although there are some limitations such as uncertainties in measured values, complex topology around the site, and the land-sea breeze effects. The assumption on the "3H behavior in vegetables or plants that the ratio of "3H concentration in plant water to "3H concentration in atmospheric water is 1/2 was shown to be conservative in terms of the audit calculation performed by the regulator. It was also found that data sets based on mixed ...

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Exogenous adenosine 5{prime}-triphosphate (ATP) mobilized intracellular calcium in human carcinoma A43l cells and in Swiss 3T3 and 3T6 mouse fibroblasts by increasing inositol trisphosphate similar to well down growth factors (platelet-derived growth factor (PDGF), epidermal growth factor (EGF), bradykinin (BK), serum). Calcium mobilization was examined by video imaging of fura-2 fluorescence is single cells, following the radioactive isotope {sup 45}Ca, and monitoring the decrease in fluorescence of cells loaded with chlortetracycline. Uridine 5{prime}-triphosphate, but not other nucleotides, mimicked ATP. Single-cell analysis revealed synchronous responses in 10 sec to ATP, BK or serum, while PDGF (3T3) and EGF (A431) produced slower signals with significant cell-to-cell variation. PDGF desensitized 3T3 cells to ATP and BK added 100 sec later but ATP or BK did not desensitized to PDGF. Homologous desensitization was seen ...

Science.gov (United States)

PMID:21765026

CERN Document Server

We present a phenomenological analysis of the recent Tevatron results on the $t \\bar t$ forward-backward asymmetry and invariant-mass spectrum assuming a new contribution from an s-channel gluon resonance with a mass in the range from 700 to 2500 GeV. In contrast to most of the previous works, this analysis shows that for masses below ~1 TeV resonant New Physics could accommodate the experimental data. In general, we find that axial-like couplings are preferred for light and top quark couplings, and that only top quark couples strongly to New Physics. We find that composite model scenarios arise naturally from only phenomenological analyses of the experimental results. We show that our results are compatible with recent LHC limits in dijet and $t \\bar t$ production, and find some tension for large resonance mass ~2.5 TeV. We indicate as best observables for discriminating a relatively light new gluon a better resolution in CDF forward-backward ...

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The weak interaction between neutrons and protons has never been resolved experimentally. In analogy with the strong NN interaction, the weak NN interaction at low energy can be parametrized in terms of a meson exchange model with parity violating meson-nucleon couplings. Unlike the measured proton-proton weak interaction, the neutron-proton weak interaction is sensitive to the weak pion-nucleon coupling constant H{sub {pi}}{sup 1}. This coupling, which is responsible for the longest-ranged part of the weak NN interaction and is therefore an essential part of any description of weak interactions in nuclei, remains undetermined despite many years of effort. A measurement of the gamma ray directional asymmetry A{sub {gamma}} in the capture of polarized neutrons by parahydrogen has been proposed at Los Alamos National Laboratory. The goal of this experiment is to determine A{sub {gamma}} with a relative standard uncertainty of <5x10{sup -9}, which is smaller ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Capillary permeability is a tightly regulated feature of microcirculation in all organ beds. In sepsis, this feature is fundamentally altered. We have previously reported elevated levels of angiopoietin-2 in patients with septic shock, and have investigated tumor necrosis factor (TNF)-related and weak inducer of apoptosis (TWEAK), which mediates both angiogenesis and inflammation, in those patients. Enzyme-linked immunoassay was used to measure serum TWEAK levels in 20 patients with septic shock, all of whom were treated by direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX), and in 20 non-septic controls. The TWEAK levels were higher in patients with septic shock (192.8--230.5-pg/mL) than in controls (84.1--28.7-pg/mL, P-=-0.043). Between 11 survivors and 1...

International Nuclear Information System (INIS)

In quantifying health risks arising from radiation exposure and synergistic effects promoted by radiation the dose-effect relationship must be used as a basis. Special problems arise in the extrapolation of experimental results or in the treatment of data in the region of low doses administered over long periods of time. For radiation protection purposes, especially manifestations of cancer and genetic effects are significant. The International Commission on Radiation Protection has published binding guiding values on the basis of which to assess the risk of cancer. The cancer risk and genetic risks are estimated for relevant dose ranges and compared with other factors of civilization. For the most important chemical pollutants emitted into the environment the possibilities of impacts arising from synergistic effects are discussed on the basis of the rules and regulations specified in German antipollution legislation. (orig.) 891 HP/orig. 892 ...

International Nuclear Information System (INIS)

To sophisticate the nuclear fuel recycling processes, the transfer percentages for Pd, Mo, Te, and Sb should be determined. Each element solution containing NaNO_3 or HNO_3 was fed consistently into the thin film evaporator regulated in vac and at 50 deg C. The analyte percentages in the inside of the lid, in the condenser, and in the distillate were 10"-"1%/m"2, 10"-"3%/m"2, and 10"-"3% (DF = 10"5), respectively. The Mo percentage in the condenser was lower by a factor of 10 than those of other elements investigated. The NO_3"- percentages were nearly constant despite increasing HNO_3 concentrations, however, the ratios decreased with increasing NaNO_3 concentrations. (author)

International Nuclear Information System (INIS)

Material degradation of pressure tubes, which are the most important components in CANDU fuel channel, can only be evaluated by removing and examining them(material surveillance). This study aimed at establishment of overall evaluation technology including the evaluation of the material degradation for the integrity of pressure tubes of Wolsung units. Material tests for pressure tubes were performed as follows; (1) Evaluation on life limiting factors of pressure tubes (2) Review on leak-before-break and integrity maintenance technology of pressure tubes (3) Survey on selection criteria for tubes to be inspected and on related regulations for material surveillance (4) Analysis of material surveillance test procedure (5) Basic examinations of Wolsung unit 1 pressure tube material(TEM, texture, chemical component etc) (6) Manufacture of test equipments and test (DHCV, hydriding, grip and tensile specimen etc). 23 figs, 6 tabs, 59 refs. (Author).

International Nuclear Information System (INIS)

After having discussed the peculiarities of children in X-ray diagnosis the application of the effective as well as the mean equivalent doses as to the determination of the radiation exposure in children is represented. In using computerized tomograms to determine position and extent of an organ the exposure by repeated X-raying was calculated referring to the entrance dose. Entrance dose measurements for all types of X-ray examination in hospitals and ascertainments of the frequency of radiograms in 20 X-ray departments were used to determine per capita and collective doses, resp., in several age groups. Alltogether, the per capita dose of children in the GDR amounts to 30% of that of adults. Conclusions were drawn as to taking measures to further reduction of radiation exposure: (1) Technical measures, such as positioning of patients, shielding of organs, quality assurance; (2) elaboration of regulations concerning the execution of X-raying in children and ...

British Library Electronic Table of Contents (United Kingdom)

First generation biofuels provide a number of ecosystem services (e.g., fuel, climate regulation) but they also compromise other ecosystem services (e.g., food, freshwater services) which are of paramount value to human wellbeing. However, this knowledge is fragmented and little is known about how the ecosystem services provided and/or compromised by biofuels link to human wellbeing. In fact, whether biofuels production and use can have a negative or positive impact on the environment and society depends on several interconnected factors. This paper provides a critical review of the drivers, impacts and tradeoffs of biofuel production and use. In particular, it rationalizes the evidence coming from diverse academic disciplines and puts it into perspective by employing the ecosystem service...

CERN Document Server

We make a comparison of the predicted effective weak mixing angle, the Z-on resonance asymmetries and the W-boson mass to the LEP and SLD data at their present status. We find that the predicted MSSM values for the effective weak mixing angle are in agreement with the LEP+SLD average value for a ``heavy'' SUSY breaking scale while we observe an agreement with SLD data in the case of a ``light'' SUSY breaking scale. The resulting values for the W-boson mass and for the electron left-right asymmetries are compatible with CDF,UA2,DO and LEP data respectively. Unexpectedly we find that the supersymmetric QCD contributions to the Z-observables tend to vanish everywhere in the M1/2-M0 plane. Furthermore, values of M1/2 which are greater than 500 GeV are favoured by the MSSM if one considers the current experimental value for the strong coupling.

International Nuclear Information System (INIS)

We study CP-violating phenomena in the production, mixing and decay of a coupled system of CP-violating neutral Higgs bosons at #gamma##gamma# colliders, assuming a Minimal Supersymmetric Standard Model (MSSM) Higgs sector in which CP violation is radiatively induced by phases in the soft supersymmetry-breaking gaugino masses and third-generation trilinear squark couplings. We discuss CP asymmetries in the production and decays of #mu#"+#mu#"-, #tau#"+#tau#"-, b-bar b and t-bar t pairs. We find large asymmetries when two (or all three) neutral Higgs bosons are nearly degenerate with mass differences comparable to their decay widths, as happens naturally in the CP-violating MSSM for values of tan#beta#-bar 5 (30) and large (small) charged Higgs-boson masses.

International Nuclear Information System (INIS)

The mass asymmetry of fragments from nuclear fission of heavy nuclei is reviewed. While mass asymmetry is a common and well-known phenomenon for low-energy fission of the lighter actinides, more recent experiments have demonstrated that, for the heaviest actinides, the mass distribution switches to a symmetric one. On the other hand, it has been discovered that, though for fissioning nuclei with mass numbers A< or #approx#225 the mass distribution is basically symmetric, an asymmetric component is clearly to be identified for nuclei down to the Pb-region. In the absence of a generally accepted dynamical theory of fission, the above experimental findings are discussed in terms of static energy considerations. Triggered from the outset by the structure of the potential energy surface at the saddlepoint, the energy balance at the scission point between the available energy (Q-value) of the reaction and the Coulomb and deformation energy of the ...

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The {rvec n} + p {yields} d + {gamma} experiment under construction at LANSCE studies the weak interaction between neutrons and protons. The experiments will measure the directional dependence of the parity-violating {gamma}-ray asymmetry, A{sub {gamma}}, in the polarized cold neutron capture by para-hydrogen. The goal is to measure A{sub {gamma}} with uncertainty of 0.5 x 10{sup -8}, 10% of its predicted value. A{sub {gamma}} primarily isolates the {Delta}I = 1 component of the hadronic weak interaction and thus will determine the long-range weak pion-nucleon coupling constant H{sub {pi}}{sup 1}. The experiment is carefully designed for the LANSCE pulsed spallation neutron source to achieve the proposed statistical precision and to control systematic errors. We discuss the experiment and its status.

Science.gov (United States)

Somatogenic hormones play an important role in regulation of receptors for prolactin (PRL) and estrogen. Plerocercoids of the tapeworm, S. mansonoides produce a factor which mimics some, but not all of the actions reported for GH. Intact female rats were subjected to a constant infusion of plerocercoid growth factor (PGF) via a subcutaneous infection for two weeks to determine if PGF influences receptors for PRL, GH or estradiol. The rate of weight gain in the PGF-treated rats was accelerated in spite of a marked reduction in serum GH. Partially-purified PGF specifically displaced [125I]hGH from rat liver receptors but microsomes prepared from rats treated with PGF specifically bound significantly less [125I]hGH than microsomes from control rats. The reduction in [125I]hGH binding was not due to occupancy or to a change in affinity but to a suppression in receptor concentration. Scatchard analysis of [3H]estradiol binding ...

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This paper examines the dynamic international political economic environment in which petroleum exploration and production companies must operate when considering investments in the economically transitional nations of the former Soviet Union or developing nations In this period of critical global changes low oil prices is only one factor with which petroleum companies Must be. concerned in their investment decisions Other factors include the transition from a bipolar world to a multipolar world of free trade zones. the general malaise of the international economy public and political recognition that nations and industries can no longer practice environmental {open_quotes}beggar-thy-neighbor{close_quotes} policies, and the rejection of aggregate national economic growth policies for sustainable economic development policies in both the Developed and developing world This paper focuses on actions which investing petroleum exploration and ...

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The Drosophila melanogaster tissue-specific transcription factor NTF-1 was originally identified in vitro as a protein that could bind to and activate transcription from the Dopa decarboxylase (Ddc) gene. A structure-function analysis of NTF-1 led to the identification of a discrete amino-terminal activation domain. Here, we report that an NTF-1 mutant lacking the activation domain acts as a trans-dominant inhibitor of NTF-1 activation in tissue culture cells by forming inactive heterodimers with the full-length protein. Ectopically expressing this dominant-negative protein or the full-length protein in developing Drosophila embryos leads to dire developmental consequences. Overexpressing the trans-dominant NTF-1 leads to lethality, while overexpressing full-length NTF-1 results in both lethality and morphogenetic defects. Our results suggest that both the activity and the regulation of NTF-1 are critical for viability and proper development of ...

Science.gov (United States)

The insulin signaling pathway, involving protein kinase B (PKB) and mitogen-activated protein kinase (MAPK), mediates the biological response to insulin and several growth factors and cytokines. To investigate the correlation between glucose transporter (Glut) biosynthesis and the insulin signaling pathway activated by novel compounds of Liriope platyphylla (LP9M80-H), alterations in Glut and key protein expression in the insulin signaling pathway were analyzed in the liver and brain of ICR mice treated with LP9M80-H. An in vitro assay showed that the highest level of insulin concentration was observed in the LP9M80-H-treated group, followed by the LP-H, LP-M, LP-E, and LP9M80-C-treated groups. Therefore, LP9M80-H was selected for use in studying the detailed mechanism of the insulin signaling pathway in animal systems. In an in vivo experiment, LP9M80-H induced a significant increase in glucose levels and a decrease of insulin concentration in the blood of mice, ...

International Nuclear Information System (INIS)

Up to now the retention of radioactive material for nuclear facilities has been based on the maximum individual dose. The maximum individual dose can locally be lowered considerably by higher dissolution. In general, the collective doses are not lowered by this. In order to set up regulations concerning collective doses, the new recommmendations of the ICRP are very welcome. However, the costs of detriment and the period to be considered have not yet been defined. Therefore there are no fixed methods for carrying out a cost-benefit analysis. Furthermore, for nuclear technology the costs and the effectiveness of the retention of radioactive material for non-realized facilities can only be quoted roughly, which makes a cost-benefit analysis more difficult. A cost-benefit analysis for the retention of radioactive material in nuclear power plants with LWRs and reprocessing plants of the PUREX process has been carried out with best estimate data. The results show that ...

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This report continues the studies of simplified methods, of magnetic diagnostics in application to TCA/BR tokamak. Here we study the accuracy of known formula for {beta}{sub 1} + l{sub 1}/2 determination from the poloidal magnetic field asymmetry. Errors of the diamagnetic measurements due to vibrations of the vacuum vessel are also considered. (author). 3 refs., 1 fig., 1 tab.

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Because every cell within the body has the same genetic information, a significant problem in biology is to understand how cells within a tissue express genes selectively. A sophisticated network of physical and biochemical signals converge in a highly orchestrated manner to bring about the exquisite regulation that governs gene expression in diverse tissues. Thus, the ultimate decision of a cell to proliferate, express tissue-specific genes, or apoptose must be a coordinated response to its adhesive, growth factor, and hormonal milieu. The unifying hypothesis examined in this overview is that the unit of function in higher organisms is neither the genome nor the cell alone but the complex, three-dimensional tissue. This is because there are bidirectional connections between the components of the cellular microenvironment (growth factors, hormones, and extracellular matrix) and the nucl2048 These connections are made via ...

UK PubMed Central (United Kingdom)

MicroRNAs (miRs) can regulate many cellular functions, but their roles in regulating responses of vascular endothelial cells (ECs) to mechanical stimuli remain unexplored. We hypothesize that the physiological...Full Text Available

UK PubMed Central (United Kingdom)

Hyaluronan (HA) is important for joint cavitation, lubrication, volume regulation and synovial fluid drainage but little is known about the regulation of joint HA synthesis/secretion in vivo....Full Text Available

UK PubMed Central (United Kingdom)

Cytokine regulation of synovial fluid (SF) lubricants, hyaluronan (HA), and proteoglycan 4 (PRG4) is important in health, injury, and disease of synovial joints, and may also provide powerful regulation...Full Text Available

UK PubMed Central (United Kingdom)

Histamine has been proposed to be an important regulator of energy intake and expenditure. The aim of this study was to evaluate histamine regulation of glucose and lipid metabolism and development...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundIt is often desirable to separate effects of different regulators on gene expression, or to identify effects of the same regulator across several systems. Here, we focus...Full Text Available

International Nuclear Information System (INIS)

In order to investigate the systematics of the loop expansion in high temperature gauge theories beyond the leading order hard thermal loop (HTL) approximation, we calculate the two-loop electron proper self-energy #SIGMA# in high temperature QED. The two-loop bubble diagram of #SIGMA# contains a linear infrared divergence. Even if regulated with a nonzero photon mass M of order of the Debye mass, this infrared sensitivity implies that the two-loop self-energy contributes terms to the fermion dispersion relation that are comparable to or even larger than the next-to-leading order (NLO) contributions of the one-loop #SIGMA#. Additional evidence for the necessity of a systematic restructuring of the loop expansion comes from the explicit gauge-parameter dependence of the fermion damping rate at both one and two loops. The leading terms in the high temperature expansion of the two-loop self-energy for all topologies arise from an explicit hard-soft ...

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ABSTRACT-Here we identify release of annexin A2 into the culture medium in response to low dose X-ray radiation exposure and establish functional linkages to an established paracrine factor-mediated anchorage-independent growth response. Using a standard bicameral coculture model, we observe that annexin A2 levels associated with non-irradiated neighboring cells seeded in the lower chamber (annexin A2 silenced [shRNA] JB6 cells) are increased upon coculture with irradiated (10-50 cGy) JB6 cells seeded in the upper chamber, relative to coculture with sham exposed JB6 cells seeded in the upper chamber, suggesting that annexin A2 released into the medium is capable of communicating in a paracrine fashion. Using a previously established coculture model, we observed that the paracrine factor-mediated anchorage-independent growth response to low dose X-ray radiation is markedly reduced when irradiated annexin A2 silenced (shRNA) JB6 cells are used, ...

International Nuclear Information System (INIS)

Hepatic injury and regeneration of the liver are associated with activation of hepatic stellate cells (HSC). Fibroblast growth factors (FGFs) and their receptors are important regulators of repair in various tissues. HSC express FGFR3IIIc as well as FGFGR4 and different spliced FGFR1IIIc and FGFR2IIIc isoforms which differ in the presence or absence of the acid box and of the first Ig-like domain. Expression of FGF9, known to be capable to activate the HSC FGFR2/3-isoforms, was increased in HSC in liver slice cultures after exposition to carbon tetrachloride, as an acute liver injury model. FGF9 significantly stimulated 3-H thymidine incorporation of hepatocytes, but failed to induce DNA synthesis in HSC despite the fact that FGF9 induced a sustained activation of extracellular signal-related kinases (ERK) 1/2. FGF9 induced an increased phosphorylation of Tyr436 of the fibroblast growth factor receptor substrate (FRS) 2, ...

UK PubMed Central (United Kingdom)

We report the identification and characterization of a new Drosophila clock-regulated gene, takeout (to). to is a member of a novel...Full Text Available

UK PubMed Central (United Kingdom)

The growth and development of rice (Oryzae sativa) seedlings was shown to be regulated epigenetically by a fungal endophyte. In contrast to un-inoculated (nonsymbiotic) plants, endophyte...Full Text Available

Science.gov (United States)

Federal regulators were set to vote on a plan to protect deep water corals and other sensitive fish habitats that will likely include a permanent ban on ...

UK PubMed Central (United Kingdom)

The regulation of the glutamate dehydrogenases was investigated in wild-type Neurospora crassa and two classes of mutants altered in the assimilation of inorganic nitrogen, as either...Full Text Available

UK PubMed Central (United Kingdom)

The pleiotropic actions of neuromodulators on pre- and postsynaptic targets present challenges to disentangling the mechanisms underlying regulation of synaptic transmission. Within the striatum,...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A closed economic system was assumed for the Veneto Region (Italy) in order to define an appropriate input-output model and assess the future economic and environmental impacts of proposed actions for energy source development and economic growth. Present and forecasted energy demands (to the year 2000) were determined by energy source, e.g., natural gas, coal, petroleum and hydropower for the different consuming sectors - agriculture, transportation, industry, etc. Forecasts were made of the air pollution expected as a result of different types of energy and technology inputs for each sector. These considered planned retrofits towards clean combustion systems. Costs were estimated for the implementation of proposed pollution abatement measures, as well as, for the effects of energy use related environmental damage and measures to restore the environment. Some of the factors taken into account were: the regional impacts of the Italian National Energy Plan; the ...

Science.gov (United States)

Myostatin is a member of the transforming growth factor-{beta} (TGF-{beta}) family and a strong negative regulator of muscle growth. Here, we present the crystal structure of myostatin in complex with the antagonist follistatin 288 (Fst288). We find that the prehelix region of myostatin very closely resembles that of TGF-{beta} class members and that this region alone can be swapped into activin A to confer signalling through the non-canonical type I receptor Alk5. Furthermore, the N-terminal domain of Fst288 undergoes conformational rearrangements to bind myostatin and likely acts as a site of specificity for the antagonist. In addition, a unique continuous electropositive surface is created when myostatin binds Fst288, which significantly increases the affinity for heparin. This translates into stronger interactions with the cell surface and enhanced myostatin degradation in the presence of either Fst288 or Fst315. Overall, we have identified ...

Science.gov (United States)

NFAT involvement in adipocyte physiological processes was examined by treatment with CsA and/or GSK3{beta} inhibitors (Li{sup +} or TZDZ-8), which prevent or increase NFAT nuclear translocation, respectively. CsA treatment reduced basal and TNF{alpha}-induced rates of lipolysis by 50%. Adipocytes preincubated with Li{sup +} or TZDZ-8 prior to CsA and/or TNF{alpha}, exhibited enhanced basal rates of lipolysis and complete inhibition of CsA-mediated decreased rates of lipolysis. CsA treatment dramatically reduced the mRNA levels of adipocyte-specific genes (aP2, HSL, PPAR{gamma}, ACS and Adn), compared with control or TNF{alpha}-treatment, whereas Li{sup +} pretreatment blocked the inhibitory effects of CsA, and mRNA levels of aP2, HSL, PPAR{gamma}, and ACS were found at or above control levels. NFAT nuclear localization, assessed by EMSA, confirmed that CsA or Li{sup +} treatments inhibited or increased NFAT nuclear translocation, respectively. These results show that NFAT proteins in ...

British Library Electronic Table of Contents (United Kingdom)

In closed systems, the O2 compensation point (?O) was previously defined as the upper limit of O2 level, at a given CO2 level, above which plants cannot have positive carbon balance and survive. Studies with 18O2 measure the actual O2 uptake by photorespiration due to the dual function of Rubisco, the enzyme that fixes CO2 and takes O2 as an alternative substrate. One-step modelling of CO2 and O2 uptakes allows calculating a plant specificity factor (Sp) as the sum of the biochemical specificity of Rubisco and a biophysical specificity, function of the resistance to CO2 transfer from the atmosphere to Rubisco. The crossing points (Cx, Ox) are defined as CO2 and O2 concentrations for which O2 and CO2 uptakes are equal. It is observed that: (1) under the preindustrial atmosphere, photorespir...

International Nuclear Information System (INIS)

The supply of electronic instrumentation and controlling (I and C) equipments in Daya Bay Nuclear Power Station depends on importation up to now, however, reliable supply of spare parts is presently threatened by many factors. Consequently, Daya Bay Nuclear Power Station tries to localize these equipments. According to a survey, China has possessed the ability to undertake the research, development and production of the I and C system in nuclear power independently. We propose that localization should firstly starts with the production of replacement board and parts for analogical I and C system, gradually leads to the substitution of system cabinet units, and finally realize the independent research, development and production of advanced digital main control system. A series of prominent problems of producing nuclear grade I and C equipments are focused on the designing, manufacturing, testing and reliability evaluation. In this paper, technical procedures, ...

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We report here a study of the mechanisms leading to loss of growth control in chicken embryo fibroblasts transformed by Rous sarcoma virus (RSV). We have been particularly concerned with the role of the src gene in this process, and have used RSV mutants temperature sensitive (ts) for transformation to investigate the nature of the growth regulatory lesion. The two principal findings were (1) the stationary phase of the cell cycle (G{sub 1}) in chick embryo fibroblasts seems to have two distinct regulatory compartments (using the terminology of Brooks et al. we refer to these as 'Q' and 'A' states). When rendered stationary at 41.5 C by serum deprivation, normal cells enter a Q state, but cells infected with the ts-mutant occupy an A state. (2) Whereas normal cells can occupy either state depending on culture conditions, the ts-infected cells, at 41.5 C, do not seem to enter Q even though a known src gene product, a kinase, is reported to be inactive ...

Energy Technology Data Exchange (ETDEWEB)

This paper reported on a study that evaluated the energy consumption of cotton gins used in Australia. The average electricity use is 52.3 kWh per bale. In practicality, the electricity consumption for different gins is correlated linearly with the bale numbers produced. The cost of electricity is therefore important in cotton ginning operations. The power factor in all the gins monitored in this study was greater than 0.85. The study showed that the use of gas dryers was highly influenced by the cotton moisture and regulated drying temperature. In general, electricity and gas consumption comprised 61 and 39 per cent of total energy use respectively. The study showed that 60.38 kg of carbon dioxide are emitted for ginning each bale of cotton. This paper described a newly developed method for monitoring the energy performance in cotton gins. Detailed monitoring and analysis carried out at 2 gin sites revealed that electricity consumption is not ...

International Nuclear Information System (INIS)

Exposure control at the operating Nuclear Power Station is a major concern. TAPS Unit-4 is the first Pressurized Heavy Water Reactor of 540 MWe electrical capacity. This unit was made critical on March 6, 2005. In-depth review of radiation safety was done to identify the impact of design modification on dose rates at various locations and on the equipment's. Problems encountered in controlling the dose rates in 220 MWe electrical are eliminated by appropriate design modifications. Due to higher capacity of the unit there are design changes in major systems such as reactor core, primer heat transport system, moderator system, reactor regulation and protection systems. Reactor operations and maintenance activities during shut down contributes to exposure of the employees. Based on the experience gained in the operation of 220 MWe, design modifications incorporated in TAPS unit-4 and dose rate measurements carried out at 90 % full power, through this paper attempt is ...

Science.gov (United States)

Regulation of transcription initiation by RNA polymerase II requires TFIID, a multisubunit complex composed of the TATA binding protein (TBP) and at least seven tightly associated factors (TAFs). Some TAFs act as direct targets or coactivators for promoter-specific activators while others serve as interfaces for TAF-TAF interactions. Here, we report the molecular cloning, expression and characterization of Drosophila dTAFII60 and its human homolog, hTAFII70. Recombinant TAFII60/70 binds weakly to TBP and tightly to the largest subunit of TFIID, TAFII250. In the presence of TAFII60/70, TBP and TAFII250, a stable ternary complex is formed. Both the human and Drosophila proteins directly interact with another TFIID subunit, dTAFII40. Our findings reveal that Drosophila TAFII60 and human TAFII70 share a high degree of structural similarity and that their interactions with other subunits of TFIID are conserved.Images

British Library Electronic Table of Contents (United Kingdom)

Background & AimsMolecular mechanisms underlying alcoholic liver disease (ALD) are still not fully understood. Activating transcription factor-4 (ATF4) is the master coordinator of the integrated stress response (ISR), an adaptive pathway triggered by multiple stressors. which can promote cell death and induce metabolic dysregulation if the stress is intense or prolonged. The aim of this study was to assess the effect of alcohol on the ISR signaling pathway in human liver cells and to define the role of cytochrome P450 2E1 (CYP2E1) in this response. MethodsPrimary cultured human hepatocytes and human HepG2 cells over-expressing CYP2E1 by adenoviral infection were exposed to ethanol (25-100mM) for 8-48h. ResultsEthanol treatment of both liver cells up-regulated ATF4 as well as the pro-survi...

Science.gov (United States)

Objectives: We have previously shown that chronic exposure to ambient fine particulate matter (less than 2.5 ?m in aerodynamic diameter, PM(2.5)) pollution in conjunction with high-fat diet induces insulin resistance through alterations in inflammatory pathways. In this study we evaluated the effects of PM(2.5) exposure over a substantive duration of a rodent's lifespan and focused on the impact of long-term exposure on adipose structure and function.Methods and Results: C57BL/6 mice were exposed to PM(2.5) or filtered air (FA) (6 hours/day, 5 days/week) for duration of 10 months in Columbus, OH. At the end of the exposure, PM(2.5)-exposed mice demonstrated insulin resistance (IR) and a decrease in glucose tolerance compared with the FA-exposed group. Although there were no significant differences in circulating cytokines between PM(2.5)- and FA-exposed groups, circulating adiponectin and leptin were significantly decreased in PM(2.5)-exposed group. PM(2.5) exposure also led to ...

CERN Document Server

Some extensions of the Standard Model often predict a Z'gauge boson which mediates flavor-changing neutral-current (FCNC) interaction between up and top quarks. These new physics models are phenomenologically attractive because they can explain the top quark forward-backward asymmetry $A^t_FB$ measured recently by the Tevatron collider. In addition, they will induce the top quark FCNC decays and the like-sign top pair production which can be explored at the LHC. In this work we focus on two such models (the left-right model and the $U(1)_X$ model) to investigate their correlated effects on $A^t_FB$, the FCNC decays $t -> u V (V=g,Z,\\gamma)$ and the like-sign top pair production at the LHC. We also pay special attention on the most recently measured $A^t_FB$ in the large invariant mass region. We find that under the current experimental constrains both models can alleviate the deviation of $A^t_FB$ and, meanwhile, enhance some FCNC decays and the like-sign pair ...

Energy Technology Data Exchange (ETDEWEB)

We measured ESR of phosphorous-doped silicon with a low concentration of P, n, at high magnetic fields and low temperatures to investigate the states of nuclear spin. A sample with n = 6.52 x 10{sup 16} /cm{sup 3} was studied at 2.85 T (80 GHz) from 30 K to 2.3 K by field-modulating cw-ESR for a fixed 0 dB power. As the temperature was lowered, the out-of-phase signal appeared around 18 K, reached at a maximum intensity at 13 K, and disappeared around 6 K. The out-of-phase signal is referred to the field modulation. The in-phase signal started to change from the derivative of absorption spectrum at high temperatures to absorption-like shape around 15 K and asymmetry of intensity for two peaks of hyperfine-separated signals increased as temperatures was lowered. Below 10 K, the saturation of the in-phase signal started to appear. We speculate that the asymmetry is caused by saturation effect and dynamic nuclear polarization of {sup 31}P nuclear ...

CERN Document Server

If high-redshift QSOs are ejected from the nuclei of low-redshift galaxies, as some have claimed, a large portion of their redshift must be intrinsic (non-Doppler). If these intrinsic components have preferred values, redshifts will tend to cluster around these preferred values and produce peaks in the redshift distribution. Doppler ejection and Hubble flow components will broaden each peak. Because ejection velocities are randomly directed and Hubble flow components are always positive, in this model all peaks are expected to show an asymmetry, extending further out in the red wing. If peaks are present showing this predicted asymmetry, it can lead directly to an estimate of quasar distances. Using two quasar samples, one with high redshifts and one with low, it is shown here that not only do all peaks in these two redshift distributions occur at previously predicted preferred values, they also all show the predicted extra extension in the red ...

CERN Document Server

Recently the D{\\O} Collaboration reported an observation of like-sign charge asymmetry (CA), which is about $3.2 \\sigma$ deviation from the standard model (SM) prediction. Inspired by the observation we investigate the scalar unparticle effects, under the color charge of $SU(3)_c$ symmetry, in the CP violation in neutral B meson oscillations as well as the dispersive and absorptive parts of $\\bar B_q\\leftrightarrow B_q$ transition, which can be related to the CA directly. In order to illustrate the peculiar properties of unparticle, our analysis is carried out in two scenarios for the right-handed section: (I) $\\lambda_R=\\lambda_L$ and $U_D^R=U_D^L$, where $\\lambda_{L,R}$ and $U_D^{L,R}$ are the couplings and flavor mixing matrix of left- and right-handed section, respectively; (II) $\\lambda_R >> \\lambda_L$ and $U_D^R$ is completely a free parameter. In scenario I we found that the wrong- and like-sign CA cannot be changed significantly for a SM-like ...

International Nuclear Information System (INIS)

It is shown that the Cherenkov radiation of tachyons (CRT) in general case cannot possess axial symmetry with respect to velocity v. This implies that tachyons must be vector particles. Electric dipole is used as a vector characterising the tachyon. Formulas describing the CRT spectrum are derived taking into account the asymmetry for charged tachyon and neutral tachyon dipole with arbitrary orientation with respect to v. It is shown that both types of CRT possess the same integral characteristics. A new integral of motion specific for tachyons is found. Negative results of all attempts to detect the CRT are explained.

Energy Technology Data Exchange (ETDEWEB)

Thomas Jefferson National Accelerator Facility experiment E01-012 measured the 3He spin structure functions and virtual photon asymmetries in the resonance region in the momentum transfer range 1.0 < Q2 < 4.0 (GeV/c)2. Our date, when compared with existing deep inelastic scattering data, can be used to test quark-hadron duality in g1 and A1 for 3He and the neutron. Preliminary results for A{sub 1}{sup {sup 3}He} are presented, as well as some details about the experiment.

Energy Technology Data Exchange (ETDEWEB)

The RSS collaboration has measured the spin structure functions of the proton and the deuteron at Jefferson Lab using the Hall C HMS spectrometer, a polarized electron beam and a polarized solid target. The asymmetries A and A were measured in the region of the nucleon resonances (0.82 GeV < W < 1.98 GeV) at an average four momentum transfer of Q2 = 1.3 GeV2. The extracted spin structure functions and their kinematic dependence will make a significant contribution in the study of higher-twist effects and polarized duality tests. A description of the experiment and the latest findings of the analysis will be presented.

International Nuclear Information System (INIS)

Two experiments are currently underway to measure the single-particle weak mixing matrix element for the 1064 KeV transition in "2"0"7Pb. One experiment measures the circular polarization of the 1064 KeV gamma ray emitted from an unpolarized source, while the other experiment measures the forward-backward asymmetry of gamma rays emitted from a polarized source. Analysis of the first set of polarized source data yields an upper limit of 46 eV for the single-particle weak mixing matrix element. copyright 1995 American Institute of Physics.

British Library Electronic Table of Contents (United Kingdom)

Resonant scattering of atoms with formation of the Feshbach resonance in the presence of a laser radiation coupling the levels of two bound atoms (a molecule) is considered. The laser field leads to a second resonance in scattering and broadening of resonances, which facilitates the possibility of experimental observation of asymmetry of the total scattering cross-section arising because of interference between resonant and potential scatterings. The effects associated with interference of the two channels of decay of a bound system of two atoms (a molecule) in the laser field are studied. An expression is obtained for the scattering length in collision of two cold atoms in the field of laser radiation.

British Library Electronic Table of Contents (United Kingdom)

Abstract The creation of chirality on Earth and the development of chiral life have been discussed in this highlight. Convincing evidence for the introduction of chirality on Earth is still fragmentary. We believe that by a combination of chiral crystallization and formation of helical polymers with preferred chiral conformational structure is the key to this question. This concept of macromolecular asymmetry has inspired ideas and resulted in possible rules for how chiral life as we know it, could have been introduced. These investigations needed the understanding of the requirements for chiral crystallization, for the stereochemistry of the initial formation of helical polymers, the measurements of optical activity of solids and their coordination with the fundamentals of chirality. Spac...

DEFF Research Database (Denmark)

Udgivelsesdato: 2002-May

DEFF Research Database (Denmark)

Udgivelsesdato: MAR

KoreaScience (Korea)

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KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

The naive time reversal odd (T-odd) parton distribution $h_{1}^{\\perp}$, the so-called Boer-Mulders function, for both $u$- and $d$-quarks is considered in the diquark spectator model. While other approaches give evidence that the signs of the Boer-Mulders function for both flavors $u$ and $d$ are the same and negative, previous caculations in the diquark-spectator model found $h_{1}^{\\perp(u)}$ and $h_{1}^{\\perp(d)}$ have differnet signs. The flavor dependence is of significance for the analysis of the azimuthal $\\cos(2\\phi)$ asymmetries in unpolarized SIDIS and DY-processes, as well as for the overall physical understanding of the distribution of transversely polarized quarks in unpolarized nucleons. We find substantial differences with previous work. In particular we obtain estimates of the zeroth, half and first moments of Boer-Mulders functions that are negative over the full range in Bjorken $x$ for both the up and down quarks. In conjunction with the ...

Science.gov (United States)

Hypercholesterolemia

Environmental Research Database

DescriptionFarm-level estimates of the financial impact of regulation are important indicators of the effect that a regulation have. Such estimates should be included in RIA, particularly within the Small Firms Impact Test. This farm-level analysis can be used in the RIA to inform judgements of the affordability of the regulation proposal. It will help to identify which farm types are likely to be financially had-hit from the regulation. Farm-level cost estimates for each regulation are also required t [continued...

International Nuclear Information System (INIS)

ADP-ribosylation factors (ARFs) are small guanine nucleotide-binding proteins that enhance the enzymatic activities of cholera toxin. Two ARF cDNAs, ARF1 and ARF3, were cloned from a human cerebellum library. Based on deduced amino acid sequences and patterns of hybridization of cDNA and oligonucleotide probes with mammalian brain poly(A)"+ RNA, human ARF1 is the homologue of bovine ARF1. Human ARF3, which differs from bovine ARF1 and bovine ARF2, appears to represent a newly identified third type of ARF. Hybridization patterns of human ARF cDNA and clone-specific oligonucleotides with poly(A)"+ RNA are consistent with the presence of at least two, and perhaps four, separate ARF messages in human brain. In vitro translation of ARF1, ARF2, and ARF3 produced proteins that behaved, by SDS/PAGE, similar to a purified soluble brain ARF. Deduced amino acid sequences of human ARF1 and ARF3 contain regions, similar to those in other G proteins, that are believed to be ...

International Nuclear Information System (INIS)

Mutations in transcription factors hepatocyte nuclear factors (HNF)-1#alpha# and HNF-1#beta# cause maturity-onset diabetes of the young (MODY) types 3 and 5, respectively. HNF-1#alpha# and HNF-1#beta# mutations are well studied in some tissues, but the mechanism by which HNF-1#alpha# and HNF-1#beta# mutations affect sucrase-isomaltase (SI) transcription in the small intestine is unclear. We studied the effects of 13 HNF-1#alpha# mutants and 2 HNF-1#beta# mutants on human SI gene transcription, which were identified in subjects with MODY3 and MODY5, respectively. Transactivation activity of 11 HNF-1#alpha# and 2 HNF-1#beta# mutants was significantly lower than that of wild (wt)-HNF-1#alpha# and wt-HNF-1#beta#. Furthermore, in co-expression studies with mutant (mu)-HNF-1#alpha#/ wt-HNF-1#beta# and wt-HNF-1#alpha#/mu-HNF-1#beta#, the combination of mu-HNF-1#alpha# (P379fsdelCT and T539fsdelC)/wt-HNF-1#beta# impaired SI transcription, but the ...

International Nuclear Information System (INIS)

1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) is an anti-inflammatory agent with a propenone moiety and chemically synthesized recently. In this study, we examined the chemopreventive effect of FPP-3 on 7,12-dimethylbenz[a]anthracene (DMBA)-induced genotoxicity in MCF-7 cells. FPP-3 reduced the formation of the DMBA-DNA adduct. DMBA-induced CYP1A1 and CYP1B1 gene expression and enzyme activity were inhibited by FPP-3. It inhibited DMBA-induced aryl hydrocarbon receptor (AhR) transactivation and DMBA-inducible nuclear localization of the AhR. Induction of detoxifying phase II genes by chemopreventive agents represents a coordinated protective response against oxidative stress and neoplastic effects of carcinogens. Transcription factor NF-E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase II detoxifying and antioxidant enzymes, such as glutathione S-transferase (GST) and NAD(P)H:quinone ...

Energy Technology Data Exchange (ETDEWEB)

The goal of this study is to estimate the relevance and Influence of the Existing Regulation and the RI-PBR to the institutionalization of the regulatory system. This study reviews the current regulatory system and the status of the RI-PBR implementation of the US NRC and Korea based upon SECY Papers, Risk Informed Regulation Implementation Plan (RIRIP) of the US NRC and other domestic studies. In order to investigate the perceptions, knowledge level, ground for the regulatory change, a survey was performed to Korean nuclear utilities, researchers and regulators on the perception on the RIR. The questionnaire was composed of 50 questions regarding personal details on work experience, level of education and specific field of work ; level of knowledge on the risk informed performance based regulation (RI-PBR); the perception of the current regulation, the effectiveness, level of ...

International Nuclear Information System (INIS)

... dose rates inhalation iodine 134 krypton 88 nuclear decay quality factor

Energy Technology Data Exchange (ETDEWEB)

The main pollutants from marine diesel engines are oxides of nitrogen (NOx), sulfur oxides (SOx) and particulates (soot). However, the proposed marine diesel engine emission regulations will primarily focus on the levels of NOx and SOx. In the future, once the proposed regulations are met, the limits and levels of other emissions will come under increasing scrutiny, such as particulates, hydrocarbons and carbon monoxide. Regardless of the type of pollutant, there are generally two classes of emission control: (1) techniques that reduce the amount of pollutant formed in the combustion process, or (2) prevent the pollutants from reaching the atmosphere. Unfortunately, some of these control techniques will not be able to meet the incoming regulations. Therefore, this paper identifies the diesel engine emissions of concern, the impending regulations, and the merits of current and future emission control ...

International Nuclear Information System (INIS)

This current world population has significantly added to the pressures placed upon our finite resources and our resulting ability to feed ourselves. In order to cope with current and future demands, the two established lines of action, that is, reduced population growth and expansion of agricultural production, must be supplemented with the parallel activity of reducing food losses during and after harvest. For developing countries in particular, enormous post-harvest losses result from spillage, contamination, pests and physiological deterioration during storage. Studies in these countries indicate that post-harvest losses are enormous and amount to tens of millions of tons per year valued at billions of dollars. Programs to reduce post-harvest losses, if applied properly, can result in realistic yield increases between 10 and 30%, which can be directly converted into increased consumption for humans. Post-harvest losses vary greatly and are a function of the crop variety, pest ...

UK PubMed Central (United Kingdom)

Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function. Acetylation of the Tm N-terminal...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNFκB signaling is of paramount importance in the regulation of apoptosis, proliferation, and inflammatory responses during human development and homeostasis, as...Full Text Available

UK PubMed Central (United Kingdom)

In many dinoflagellate species, the plastid genome has been proposed to exist as a limited number of single-gene minicircles, and many genes normally found in the plastid genome are nuclear-encoded....Full Text Available

UK PubMed Central (United Kingdom)

• Background and Aims Development and architecture of plant roots are regulated by phytohormones. Cytokinin (CK), synthesized in the root cap, promotes cytokinesis, vascular...Full Text Available

UK PubMed Central (United Kingdom)

We have used the two-electrode voltage clamp technique and the patch clamp technique to investigate the regulation of ROMK1 channels by protein-tyrosine phosphatase (PTP) and protein-tyrosine...Full Text Available

UK PubMed Central (United Kingdom)

The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1...Full Text Available

UK PubMed Central (United Kingdom)

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated...Full Text Available

UK PubMed Central (United Kingdom)

Hypothalamic systems which regulate appetite may be permanently modified during early development. We have previously reported hyperphagia and increased adiposity in the adult offspring of rodents fed...Full Text Available

UK PubMed Central (United Kingdom)

AMP-activated-protein-kinase (AMPK) is a key sensor and regulator of cellular and whole-body energy metabolism and plays a key role in regulation of lipid metabolism. Since lipid metabolism...Full Text Available

UK PubMed Central (United Kingdom)

The cytokine interleukin-7 (IL-7) has essential growth activities that maintain the homeostatic balance of the immune system. Little is known of the mechanism by which IL-7 signaling regulates metabolic...Full Text Available

UK PubMed Central (United Kingdom)

This paper describes a new technique that can be used to study chloroplast volume regulation in vivo. Nuclear magnetic resonance spectroscopy was used to measure relative amounts of chloroplast water...Full Text Available

UK PubMed Central (United Kingdom)

Keap1 regulates Nrf2 activity in response to xenobiotic and oxidative stresses. Nrf2 is an essential regulator of cytoprotective genes. Keap1-null mice are lethal by weaning age due...Full Text Available

UK PubMed Central (United Kingdom)

Silent information regulators are potent NAD⁺-dependent protein deacetylases, which have been shown to regulate gene silencing, muscle differentiation and DNA damage repair. Here,...Full Text Available

UK PubMed Central (United Kingdom)

Higher plants use photoperiodic cues to regulate many aspects of development, including the transition from vegetative to floral development. The EARLY FLOWERING3 (ELF3)...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThough long known to affect smooth muscle biology, recent studies indicate that phosphodiesterase 5 (PDE5) is also expressed in myocardium. Recognizing that the regulation...Full Text Available

International Nuclear Information System (INIS)

Fusion energy has been studied in many countries such as U.S., France, Japan, Korea etc. Because it would provide much more energy for a given weight of fuel than any technology currently in use, and the fuel itself (primarily deuterium) exists abundantly in the Earth's ocean. Nuclear fusion reactor uses tritium and deuterium as fuel while nuclear fission reactor uses uranium and plutonium as fuel. Besides, inherent design characteristics and driving condition of nuclear fusion reactor is different from those of nuclear fission reactor. Therefore, we cannot apply the regulation rules of nuclear fission reactor to nuclear fusion reactor without change and thus it is needed to development of the safety regulation concept which reflects the characteristics of nuclear fusion reactor. Safety regulation of nuclear fusion reactor employs deterministic approach until sufficient data are secured. However, ...

Science.gov (United States)

This design manual contains descriptions of design procedures and operating experience to date, including results obtained, for secondary flow pollution control devices. Two types of combined sewer overflow regulators are described: the swirl and the helical bend regulator/separa...

UK PubMed Central (United Kingdom)

Cytokinins are hormones that regulate cell division and development. As a result of a lack of specific mutants and biochemical tools, it has not been possible to study the consequences of cytokinin...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundInterest in lycopene metabolism and regulation is growing rapidly because accumulative studies have suggested an important role for lycopene in human health promotion....Full Text Available

UK PubMed Central (United Kingdom)

Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin trafficking and is...Full Text Available

UK PubMed Central (United Kingdom)

The mechanism by which enzyme IIIglc of the bacterial phosphotransferase system regulates the activity of crystalline glycerol kinase from Escherichia coli has been studied, and the inhibitory effects...Full Text Available

UK PubMed Central (United Kingdom)

AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism; its activity is regulated by a plethora of physiological conditions, exercises and many anti-diabetic drugs. Recent...Full Text Available

UK PubMed Central (United Kingdom)

The ventromedial hypothalamus (VMH) plays a central role in the regulation of the female reproductive behavior lordosis, a behavior dependent upon the sequential activation of receptors for the ovarian...Full Text Available

Science.gov (United States)

...2010-10-01 false Department of Energy Directives. 970.0470 Section...Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS ...Matters 970.0470 Department of Energy...

International Nuclear Information System (INIS)

The Regulation 761/2001 EMAS (Environmental Management and Audit Scheme), introduced by the 1836/93 Community regulation, is one of the tools activated by the European Union in order to apply the 5. and 6. Community Environmental Programme, in the field of firm-environment interactions at first (overcoming the old Command and Control logic), then by extending its applicability to ali Organisations. EMAS is a voluntary tool that enables Organisations to evaluate their own interaction with the Environment, to plan and check the yearly improvement of their environmental performance, providing the public documented relevant information. The report illustrates the procedure far applying this regulation, its implementation and new application trends in Italy and the advantages far firms.

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

British Library Electronic Table of Contents (United Kingdom)

Innate immune responses are regulated by microorganisms and cell death, as well as by a third class of stress signal from the nervous and endocrine systems. The innate immune system also feeds back, through the production of cytokines, to regulate the function of the central nervous system (CNS), and this has effects on behaviour. These signals provide an extrinsic regulatory circuit that links physiological, social and environmental conditions, as perceived by the CNS, with transcriptional 'decision-making' in leukocytes. CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases.

Science.gov (United States)

Sep 2, 2008 ... Abstract: This tutorial is intended to serve as a guide towards proper hazardous waste management. Knowing the regulations, different ...

Science.gov (United States)

... While the large tanks served to regulate the water temper- ature, the polypropylene aquaria served as independent experimental units. ...

Science.gov (United States)

... management. 5.3 Decreased Emissions Changes in engine emission regulations are driving engine technology development. A ...

Energy Technology Data Exchange (ETDEWEB)

In this study, for the institutionalization of risk informed and performance based regulation in Korea, the latest technical movements of overseas countries are examined and reviewed. And the issues that was found when license change petition using risk information was submitted in Korean regulatory body are reviewed. Based on these review, the applicable areas to domestic situation will be found and proposed. This study can contribute to setting up the proper direction for the institutionalization of risk informed and performance based regulation.

Energy Technology Data Exchange (ETDEWEB)

While hydropower industry finds great profit opportunities in increased effective production, the host municipals have anxiety for great environmental damages. Regulations of water reservoirs. Differences between highest and lowest planned water level are specified in regulations for water reservoirs. The background for these regulations are both esthetic and environmental. (AG)

Energy Technology Data Exchange (ETDEWEB)

At moderately low momentum transfer ($-t$ up to 1 GeV$^2$) the coupling to the vector meson production channels gives the dominant contribution to real Compton and deeply virtual Compton scattering (DVCS). Starting from a Regge Pole approach that successfully describes vector meson production, the singular part of the corresponding box diagrams (where the intermediate vector meson-baryon pair propagates on-shell) is evaluated without any further assumptions (unitarity). Such a treatment explains not only the unexpectedly large DVCS unpolarized cross section that has been recently measured at Jefferson Laboratory (JLab), but also all the beam spin and charge asymmetries that has been measured at JLab and Hermes, without explicit need of Generalized Parton Distributions (GPD). The issue of the relationship between the two approaches is addressed.

International Nuclear Information System (INIS)

The aim of this report was to assess the usefulness of cerebral blood flow (CBF) scanning utilising the SPECT technique in forensic medicine cases in the area of civil law cases. CBF SPECT scanning was performed in four patients utilising "9"9"mTc-ECD and a triple-head gammacamera. In the analysis both the asymmetry index and cerebellar normalisation were applied. Reference values were obtained by studying 30 healthy volunteers. In those cases CBF SPECT scanning played an important role in forensic argument. It influenced the sentence and the amount of financial compensation. CBF SPECT scanning may provide valuable information in forensic medicine argument in civil law cases, but only when taken together with psychometric tests and other neuroimaging methods (CT, MRI). The value of CBF SPECT scanning alone may be limited in judicial proceedings. (author)

Energy Technology Data Exchange (ETDEWEB)

Inclusive double spin asymmetries obtained by scattering polarized electrons off polarized protons and deuterons have been analyzed to address the issue of quark-hadron duality in the polarized spin structure functions g^p_1 and g^d_1. A polarized electron beam, solid polarized NH_3 and ND_3 targets and the CEBAF Large Acceptance Spectrometer (CLAS) in Hall B were used to collect the data. The resulting g^p_1 and g^d_1 were averaged over the nucleon resonance energy region (M < W < 2.00 GeV), and three lowest lying resonances individually for tests of global and local duality.

Energy Technology Data Exchange (ETDEWEB)

The paper presents cloud structure models for Jupiter's Great Red Spot, Equatorial and North Tropical Zones, North and South Temperate Zones, and North and South Polar Regions. The models are based on images of Jupiter in three methane bands and nearby continuum radiative transfer calculations include multiple scattering and absorption from three aerosol layers. The model results include the transition in the upper-cloud altitude to 3 km lower altitude from the tropical zones to temperate zones and polar regions, a N/S asymmetry in cloud thickness in the tropical and temperature zones, and the presence of aerosols up to about 0.3 bar in the Great Red Spot and Equatorial Zone. It is concluded that polarization data are sensitive to aerosols in and above the upper cloud layer but insensitive to deeper cloud structure.

Energy Technology Data Exchange (ETDEWEB)

The current status of rare B decays is reviewed based on recent observation of the penguin-diagram decay B {yields} K{sup *}{gamma} at CLEO. Rare B decays provide valuable information on the Standard Model parameters, and also could be a source of direct CP violation. It is emphasized that new physics beyond the Standard Model can appear in rare B decays, in some cases more drastically than in the CP Asymmetry of the B system. Inclusive measurement of the radiative transition b {yields} s{gamma} is promising. Hadronic penguin modes are very close to being observed at CLEO, and a discovery might be just around the corner. (author). 48 refs., 6 figs., 4 tabs.

International Nuclear Information System (INIS)

We show that the recently measured asymmetry in helicity-angle spectra of the #LAMBDA#-hyperons, produced in the reaction pp#->#K"+#LAMBDA#p reaction, and the energy dependence of the total pp#->#K"+#LAMBDA#p cross-section can be explained consistently by the same #LAMBDA#p final-state interaction. Assuming that there is no final-state interaction in the #SIGMA#"0 p channel, as suggested by the available data for the reaction pp#->#K"+#SIGMA#"0p, we can also reproduce the energy dependence of the #LAMBDA#/#SIGMA#"0 production ratio and, in particular, the rather large ratio observed near the reaction thresholds. The nominal ratio of the #LAMBDA# and #SIGMA#"0 production amplitudes squared, i.e. when disregarding the final-state interaction, turns out to be about 3, which is in line with hyperon production data from proton and nuclear targets available at high energies. (orig.)

CERN Document Server

We propose a simple mechanism that may explain the observed particle-antiparticle asymmetry in the Universe. In the Einstein-Cartan-Sciama-Kibble theory of gravity, the intrinsic spin of matter generates spacetime torsion. Classical Dirac fields in the presence of torsion obey the nonlinear Hehl-Datta equation which is asymmetric under a charge-conjugation transformation. Accordingly, at extremely high densities that existed in the very early Universe, fermions have higher effective masses than antifermions. As a result, a meson composed of a light quark and a heavy antiquark has a lower effective mass than its antiparticle. Neutral-meson oscillations in thermal equilibrium therefore favor the production of light quarks and heavy antiquarks, which may be related to baryogenesis.

International Nuclear Information System (INIS)

The human erythrocyte (RBC) Rh blood group system consists of a complex of distinct integral membrane polypeptides with physical properties common to the aminophospholipid transporter responsible for the transbilayer movement of phosphatidylserine (PS) in RBC. To assess the involvement of Rh polypeptides in PS translocation, the aminophospholipid translocase was labeled with a photoactivatable PS analogue, "1"2"5I-azido-PS, and with an inhibitor of PS transport, "1"2"5I-labeled 2-(2-pyridyldithio)ethylamine. The ability of monoclonal Rh antibodies to immunoprecipitate the labeled transporter was determined. Immunoprecipitated Rh polypeptides were found to be labeled with the aminophospholipid translocase markers, suggesting that Rh proteins are involved in the transbilayer movement of PS.

Energy Technology Data Exchange (ETDEWEB)

Heterobarrier blocking structure InGaAlP visible light laser diodes employing a thin active layer (0.04 {mu}m) and asymmetry coatings have been fabricated. The high light-output power operation with this heterobarrier blocking structure was investigated. The light-output power versus cw current curve was linear up to 43 mW and a maximum light output power of 51 mW was obtained. A high-power operation such as 20 mW was maintained at 40 {degree}C. Stable oscillation in the fundamental transverse mode was obtained up to 30 mW. These results show that this heterobarrier blocking structure supplies a sufficient current confinement effect even under a high-light output power operation.

British Library Electronic Table of Contents (United Kingdom)

We investigate quantum mechanical electron transport along the long axis of the DNA molecule using an effective tight-binding model. The overall contour plot of transmission, the current-voltage characteristics, and the differential conductance are examined for the variation of backbone onsite energy, the energy-dependent hopping strength, and the contact coupling between the leads and the DNA molecule. It is shown that as backbone asymmetry increases, the merging and collapse of the two mini-bands take place and an extra resonance peak in the transmission appears. In addition, we present the modulation of voltage threshold in the current-voltage curves and a double-peak structure in the differential conductance due to the disappearance of the merged mini-band. Finally, in the Coulomb bloc...

Energy Technology Data Exchange (ETDEWEB)

The effect of asymmetry tilt angle ion implantation on polysilicon thin-film transistors (TFTs) device characteristics are investigated. This asymmetric source/drain (S/D) TFTs structure exhibits low leakage current and suppressed kink effect due to the relief of higher electric field near the drain junction side. It is shown that the optimal implantation tilt angle is 30 deg. in our annealing condition. And the anomalous off-state current is more than two orders of magnitude lower than that of the conventional TFTs. By well controlled the LDD region, this structure can act as a conventional structure in the on-state and the turn-on current will not be degraded. Besides, the device under severe hot carrier bias stress shows better hot carrier endurance.

UK PubMed Central (United Kingdom)

A summary of the effects presented here is given in the table. The designation "factor present" implies that there is knowledge (from human or animal studies, or both) of a specific factor(s) present...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

C-type natriuretic peptide (CNP) is a member of the small family of natriuretic peptides that also includes atrial natriuretic peptide (ANP) and brain, or B-type natriuretic peptide (BNP). Unlike them, it performs its major functions in an autocrine or paracrine manner. Those functions, mediated through binding to the membrane guanylyl cyclase natriuretic peptide receptor B (NPR-B), or by signaling through the non-enzyme natriuretic peptide receptor C (NPR-C), include the regulation of endochondral ossification, reproduction, nervous system development, and the maintenance of cardiovascular health. To date, the regulation of CNP gene expression has not received the attention that has been paid to regulation of the ANP and BNP genes. CNP expression in vitro is regulated by TGF-b and recepto...

Science.gov (United States)

It has been proposed that the gastrointestinal tract environment containing high levels of neuroendocrine hormones is important for gut-derived Pseudomonas aeruginosa infections. In this study, we report that the hormone norepinephrine increases P. aeruginosa PA14 growth, virulence factor production, invasion of HCT-8 epithelial cells, and swimming motility in a concentration-dependent manner. Transcriptome analysis of P. aeruginosa exposed to 500 microM, but not 50 microM, norepinephrine for 7 h showed that genes involved in the regulation of the virulence determinants pyocyanin, elastase, and the Pseudomonas quinolone signal (PQS, 2-heptyl-3-hydroxy-4-quinolone) were upregulated. The production of rhamnolipids, which are also important in P. aeruginosa infections, was not significantly altered in suspension cultures upon exposure to 500 microM norepinephrine but decreased on semisolid surfaces. Swarming motility, a phenotype that is directly ...

Science.gov (United States)

Reproductive status influences cell proliferation and the survival of new cells in the dentate gyrus of adult laboratory-reared and wild female meadow voles; reproductively inactive (RI) females have more proliferating cells and more labeled cells that survive 5 weeks vs. 2 h than reproductively active (RA) females. However, the effect of season has only been studied in a wild sample of male meadow voles and factors such as age and experience that have been shown to influence neurogenesis in the dentate gyrus of adult mammals cannot be controlled in a wild sample. Therefore, we investigated whether reproductive status regulates neurogenesis (cell proliferation and/or the survival of new cells) in the dentate gyrus of laboratory-reared adult male meadow voles so that confounding variables could be controlled. Males were acclimated to a short- or a long-photoperiod to simulate the non-breeding or breeding season, respectively, and reproductive ...

Science.gov (United States)

The human olfactomedin 4 gene (OLFM4) encodes an olfactomedin-related glycoprotein. OLFM4 is normally expressed in a limited number of tissues, including the prostate, but its biological functions in prostate are largely unknown. In this study, we found that OLFM4 messenger RNA was reduced or undetectable in prostate cancer tissues and prostate cancer cell lines. To study the effects of OLFM4 on prostate cancer progression, we transfected PC-3 prostate cancer cells with OLFM4 to establish OLFM4-expressing PC-3 cell clones. The OLFM4-expressing PC-3 cell clones were found to have decreased proliferation and invasiveness compared with vector-transfected control PC-3 cells in vitro. In addition, nude mice injected with OLFM4-expressing PC-3 cells demonstrated reduced tumor growth and bone invasion and metastasis compared with mice injected with vector-transfected control cells. Mechanistic studies revealed that OLFM4 may exhibit its anticancer effects through ...

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Many factors such as poverty, ineffective institutions and environmental regulations may prevent developing countries from managing how natural resources are extracted to meet a strong market demand. Extraction for some resources has reached such proportions that evidence is measurable from space. We present recent evidence of the global demand for a single commodity and the ecosystem destruction resulting from commodity extraction, recorded by satellites for one of the most biodiverse areas of the world. We find that since 2003, recent mining deforestation in Madre de Dios, Peru is increasing nonlinearly alongside a constant annual rate of increase in international gold price (?18%/yr). We detect that the new pattern of mining deforestation (1915 ha/year, 2006-2009) is outpacing that of nearby settlement deforestation. We show that gold price is linked with exponential increases in Peruvian national mercury imports over time (R(2)?=?0.93, ...

Energy Technology Data Exchange (ETDEWEB)

This paper proposes a novel and efficient algorithm to obtain optimal generation dispatch reflecting the operator's intention in power system rescheduling. In optimal system operation, various objectives, such as economy, quality and transmission security, need to be achieved simultaneously. However, these objectives are often contradictory and in a trade-off relationship with respect to each other thus making it difficult to handle this class of problem by conventional approaches. In the proposed algorithm, optimal generation dispatch is formulated as a multi-objective optimization problem. A fuzzy coordination technique based on fuzzy set theory is used to obtain an optimal solution. Evaluation indices composed of fuel cost, transmission line overload and AFC regulation capacity margin are measured by the membership functions, and multi-objective optimization is solved by maximizing the composite performance index, namely, the fuzzy decision-making ...

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The kinetics of benzoate degradation by the anaerobic syntrophic bacterium, Syntrophus buswellii, was studied in coculture with Desulfovibrio strain G11. The threshold value for benzoate degradation was dependent on the acetate concentration with benzoate threshold values ranging from 2.4 [mu]M at 20 mM acetate to 30.0 [mu]M at 65 mM acetate. Increasing acetate concentrations also inhibited the rate of benzoate degradation with a apparent K[sub i] for acetate inhibition of 7.0 mM. Lower threshold values were obtained when nitrate rather than sulfate was the terminal electron acceptor. These data are consistent with a thermodynamic explanation for the threshold, and suggest that there is a minimum Gibbs free energy value required for the degradation of benzoate. An acetoacetyl-CoA thiolase has been isolated from Syntrophomonas wolfei; it is apparently a key enzyme controlling the synthesis of poly-B-hydroxyalkanoate from acetyl-CoA in this organism. Kinetic characterization of the ...