Apoptosis and Proliferation During DicWoroacetic Acid (DCA) Induced Hepatocellular Carcinogenesis in the F344 Male Rat Chlorine, introduced into public drinking \\\\'ater supplies for disinfection, can react with organic compounds in surface waters to form toxic by-prod...
To determine a rat strain appropriate for carcinogenicity testing of FYX-051, a xanthine oxidoreductase inhibitor, we performed a 4-week oral toxicity study by administering 0.3, 1 and 3 mg/kg, and 1, 3 and 10 mg/kg of FYX-051 to male Sprague-Dawley (SD) and Fischer (F344) rats, respectively. Histopathology revealed that the degree of FYX-051-induced nephropathy was 3-fold stronger in SD rats than in F344 rats. Our previous study demonstrated that the key factor of species differences in FYX-051-induced nephropathy is purine metabolism. This observation led us to examine the involvement of purine metabolism in differences among two strains of rats. However, purine metabolism was proven not to be implicated as an important factor. Subsequently, other factors responsible for the strain differences were examined. FYX-051-induced increases in plasma xanthine concentrations were higher in SD rats than in ...
To determine a rat strain appropriate for carcinogenicity testing of FYX-051, a xanthine oxidoreductase inhibitor, we performed a 4-week oral toxicity study by administering 0.3, 1 and 3?mg/kg, and 1, 3 and 10?mg/kg of FYX-051 to male Sprague-Dawley (SD) and Fischer (F344) rats, respectively. Histopathology revealed that the degree of FYX-051-induced nephropathy was 3-fold stronger in SD rats than in F344 rats. Our previous study demonstrated that the key factor of species differences in FYX-051-induced nephropathy is purine metabolism. This observation led us to examine the involvement of purine metabolism in differences among two strains of rats. However, purine metabolism was proven not to be implicated as an important factor. Subsequently, other factors responsible for the strain diffe...
Ultrafine particles of Co-P were synthesized by direct ball milling of Co and P powders and also investigated as a reversible hydrogen storage electrode material. The electrochemical results demonstrated that the reversible charge-discharge capacity of the Co-P electrode can reach more than 300mAh/g. In addition, the cycling ability and high rate capability of the Co-P electrode are excellent with only 5% capacity decay after 100 cycles at a high rate of 300mA/g. The temperature-programmed desorption measurements (TPD) of the Co-P electrode revealed that the charge and discharge reactions of the Co-P electrode proceeds predominantly through electrochemical hydrogen storage mechanism and the electrooxidation of cobalt contributes only a negligible part to the reversible electrochemical capacity. (author)
The effect of butylated hydroxytoluene (BHT) pretreatment (0.5% in the diet for 10 days) on the excretion, tissue distribution and DNA binding of orally administered (/sup 14/C)aflatoxin B1 (AFB1) was determined in male Fischer F344 rats. The amount of radioactivity excreted in the urine and feces by 24 hr was higher in BHT-treated rats than in controls. Treatment with BHT enhanced the excretion of water-soluble metabolites in the urine and in the large intestines plus feces at the earlier sampling times. The amount of radioactivity bound to hepatic nuclear DNA was six times less in the BHT-pretreated rats than in controls 6 hr after administration of the isotope. The half-lives of (/sup 14/C)DNA in the rat liver were 30 and 46 hr for control and BHT-pretreated rats, respectively. These results indicate that BHT pretreatment may protect the animal from the carcinogenic effects of AFB1 by enhancing the detoxification and excretion of the ...
The maintenance of a balance between cell gain and cell loss is essential for proper liver function. The exact role of aryl hydrocarbon receptor (AhR) in regulating cell proliferation and apoptosis of liver cells remains unclear, since ligand-dependent activation of AhR has been shown to induce cell cycle arrest, proliferation, differentiation or apoptosis, depending on the cellular model used. AhR can directly interact with retinoblastoma protein in hepatic cells, forming protein complexes that can efficiently block cell cycle progression by inducing G1 arrest, or to induce the expression of inhibitors of cyclin-dependent kinases, such as p271. On the other hand, it has been suggested that AhR could play a stimulatory role in cell proliferation, either directly or by mediating a release from contact inhibition. It is now generally accepted that progenitor cells exist in the liver, are activated in various liver diseases and can form a potential target cell population for both tumor ...
LEW anti-DA kidney and DA anti-LEW kidney sera were assayed using an indirect 125I anti-immunoglobulin-binding assay with kidney homogenate as target. This allowed the full spectrum of antibodies to...Full Text Available
The Convective and Orographically-induced Precipitation Study (COPS) has the aim to advance the quality of forecasts of orographically-induced precipitation in complex terrain. COPS is a Research and Development Project of the World Weather Research Program and considered to be one of the largest field campaigns on quantitative precipitation forecasting that has been performed so far. A network of state-of-the-art active and passive remote sensing systems was combined with in total 10 airborne platforms, Meteosat rapid scans and dense networks of standard meteorological instruments during the three months long field phase (June-August, 2007) in south-western Germany/eastern France to observe atmospheric variables in the three spatial dimensions and in time. By the University of Hohenheim, two novel ground-based mobile scanning lidar systems were deployed: a scanning rotational Raman lidar which provides combined measurements of the field of ...
Semiclassical analysis of heavy ion induced transfer reactions are discussed for the quasielastic region. Some unique aspects of these reactions are shown, the variety of features which can be understood semiclassically is demonstrated, and some open problems are indicated. 28 refs., 16 figs. (LEW)
The computer program CNHSPM is listed which predicts heat pump seasonal energy consumption (including defrost, cyclic degradation, and supplementary heat) using steady state rating point performance and binned weather data. (LEW)
Separate abstracts were prepared for 60 papers in this volume of conference proceedings. None other papers in the proceedings were previously abstracted for EDB. Also included in the proceedings but not indexed separately are six workshop summaries and a session introduction. (LEW)
Progress is briefly summarized for a large number of projects in the areas of research instruments, measurement and controls engineering, reactor systems, and maintenance management. (LEW)
Both increased cell proliferation and {open_quotes}altered{close_quotes}CYP gene expression are prominent phenomena associated with liver tumor promotion by nongenotoxic carcinogen treatment. BRDU-labeled parenchymal nuclei were observed primarily in the periportal area of groups of rats, independent of nongenotoxic carcinogen treatment. Treatment with each of the 5 nongenotoxic carcinogens resulted in profound alterations in CPY gene expression at both the transcriptional and translational levels. Expression of CYP1A1, 1A1/2, 3A1, 2B1/2, and 4A immunoproteins demonstrated nongenotoxic carcinogen-specific patterns in both magnitude and zonal distribution. In agreement with the CYP immunoprotein data, treatment with each of the five nongenotoxic carcinogens resulted in a unique composition of mRNAs of CYP2B1, 2B2, 2C6, 2C11, 3A1, 3A2, and 4A1, which were variably increased or decreased relative to the untreated control livers, depending on the treatment. Similarly, the rate and pattern ...
Metabolism of benzene is thought to be necessary to produce the toxic effects, including carcinogenicity, associated with benzene exposure. To extrapolate from the results of rodent studies to potential health risks in man, one must know how benzene metabolism is affected by species, dose, dose rate, and repeated versus single exposures. The purpose of our studies was to determine the effect of repeated inhalation exposures on the metabolism of [14C]benzene by rodents. Benzene metabolism was assessed by characterizing and quantitating urinary metabolites, and by quantitating 14C bound to hemoglobin and micronuclei induction. F344/N rats and B6C3F1 mice were exposed, nose-only, to 600 ppm benzene or to air (control) for 6 hr/day, 5 days/week for 3 weeks. On the last day, both benzene-pretreated and control animals were exposed to 600 ppm, 14C-labeled benzene for 6 hr. Individual benzene metabolites in urine collected for 24 hr after the exposure ...
Scyl1 is an evolutionarily conserved N-terminal protein kinase-like domain protein that plays a role in COP1-mediated retrograde protein trafficking in mammalian cells. Furthermore, loss of Scyl1 function...Full Text Available
... I don't think the 5 categories are exclusive nor do they represent the universe of ways people best receive love and affection. The author addresses this last point somewhat by saying there are many dialects within the 5 languages. Some might view that as a cop out. My strongest complaint is that the language of the book is dumb downed to reach the lowest grade of reader. Like ...
A project to demonstrate residential heating and cooling with a well-water source heat pump is documented. The system is schematically illustrated and described, and project experience is discussed. The system is capable of using source water as cool as 40/sup 0/F. Project expenses are accounted for. (LEW)
A detailed definitive cost estimate is given for an ethanol/gasohol storage and blending terminal serving a planned distillery at a Louisiana sugar factory. Included are an analysis of the accuracy of the estimate, labor rates efficiency, materials and labor escalation, as well as detailed calculations for each account of the project. (LEW)
Research performed at LAMPF during 1985 is reported in the areas of: nuclear and particle physics; atomic and molecular physics; materials science; radiation-effects studies; biomedical research and instrumentation; nuclear chemistry; radioisotope production; and physics theory. Also reported are the status of LAMPF-II, facility development work, and accelerator operations. (LEW)
A numerical calculation procedure applicable to cavity-type receiver configurations and flow conditions was developed. Flow visualization experiments were performed, and experimental measurements of quantities valuable for the development of the numerical calculation procedure were made. The investigation is focussed on a configuration which is strongly two-dimensional in the mean flow structure (but turbulent in a truly three-dimensional sense). (LEW)
An investigation of natural convection losses from cavity-type solar central receivers is described and results are given. The approach followed was that of a fundamental experimental study in a simple cavity subject to well controlled boundary conditions. The Laser Doppler Velocimeter proved to be a useful technique to measure the velocity profiles associated with natural convection. Visualization techniques provided an understanding of the general behavior of the flow, particularly in three dimensional experiments. Experiments on systems of high Rayleigh numbers are described. (LEW)
The properties of capacitors are reviewed in general, including dielectrics, induced polarization, and permanent polarization. Then capacitance characteristics are discussed and modelled. These include temperature range, voltage, equivalent series resistance, capacitive reactance, impedance, dissipation factor, humidity and frequency effects, storage temperature and time, and lifetime. Applications of energy storage capacitors are then discussed. (LEW)
A series of speeches is presented which cover political aspects of ocean energy, legislation, the status of the DOE Ocean Energy Program, the Maritime Administration OTEC Support Program. Six workshop reports are given covering ocean energy technology and systems concepts, power systems concepts, environmental developments, energy transfer and utilization, construction and test capabilities, and industry development. (LEW)
The complex aspects of high energy physics work are briefly described, and approaches to managing them are discussed. Management of software and data are covered. For managing complexity in experimental physics, the choice of building or buying processor systems is addressed and the issues of compatibility and standardization are discussed. (LEW)
The theory of neutron moderation and spectroscopy are briefly reviewed, and moderators that are useful for Bonner sphere spectrometers are discussed. The choice of the neutron detector for a Bonner sphere spectrometer is examined. Spectral deconvolution methods are briefly reviewed, including derivative, parametric, quadrature, and Monte Carlo methods. Calibration is then discussed. (LEW)
Results are reported in the areas of: chiral fermions and anomalies, superstring finiteness, superstring phenomenology, spin splittings in heavy quarkonia, low-energy limits of superstring, a supersymmetric electroweak model with a light squark, scalar quark bound states, fermionic tachyons and Poincare representations, relativistic dynamics of spin-one particles and deuteron-nucleus scattering, interactions involving higher spin massless particles, and classical action at a distance theories which contain a cutoff. (LEW)
It is reported that due to the large demand for electricity in Japanese homes and given the fact that the energy consumption rate of air conditioners to the total energy consumption rate in an average home exceeds 20%, an energy saving-type room air conditioner is essential, also for environmental reasons. Japanese customers ranked high running costs as a major drawback of conventional equipment. Toshiba started developing the first generation energy saving air conditioners in 1993. Improvements to the concept were made and the 1995 model offers a heating COP of 4.65 and a cooling COP of 4.3 at rated conditions, an improvement of more than 30% compared to the conventional model. Various component improvements have led to this high performance including the indoor fan design, a DC compressor motor and inverter using digital sampling, advanced (PMV) control technology, and compact heat exchangers. The latest feature is genetic algorithm control. ...
A schematic of the Bench cavity receiver system is given, and the primary objectives, schedule and research plan for each of four tests are discussed. The tests are: (1) cold flow testing to functionally check all valves and their response using high pressure nitrogen gas; (2) a hot checkout to simulate both steady state and transient flux inputs to the receiver which are expected at the French facility; (3) basic performance using solar energy at the French facility; and (4) ir radiant heat testing. (LEW)
Requirements are provided for NSLS beam line front ends and vacuum interlocks. Guidelines are provided for UHV beam line vacuum systems, including materials, vacuum hardware (pumps, valves, and flanges), acoustic delay lines and beam line fast valves, instrumentation, fabrication and testing, and the NSLS cleaning facility. Also discussed are the design review for experimenters' equipment that would be connected to the NSLS and acceptance tests for any beam line to be connected with the ring vacuum. Also appended are a description of the acoustic delay line as well as the NSLS vacuum standards and NSLS procedures. (LEW)
The work reported included workshop-style, hands-on training sessions to reach three hundred residents of the Detroit area. The training was for teaching low-cost weatherization applications; teaching/constructing/installing thermal shades; and teaching/constructing/installing vertical wall solar air panels. All activities under the grant are summarized, including number and type of workshops, number of participants trained, etc. The organizations which actively supported and contributed to the program are identified, and the program's efforts and accomplishments are evaluated. (LEW)
In order to match the output capacity of a geothermal heat pump system (GHPS) with the actual load requirement, research has been carried out in finding the influence of two systematic parameters, the water flow rate inside the condenser and the compressor input frequency on the GHPS operation. Experiments are done on a small-scale GHPS at the water flow rate ranging from 0.054 kg/s to 0.174 kg/s and the frequency from 30 Hz to 55 Hz. The analysis of the experimental data reveals the relationships among the compressor frequency, the water flow rate and other important parameters such as coefficient of performance (COP), heat capacity and compressor power input. The conclusions in the paper can serve as some guidance to the load adjustment of GHPS. (author)
In the green building of Shanghai Research Institute of Building Science, the evacuated tubular solar collectors with a total area of 150 m{sup 2} were installed to provide heating for the covered area of 460 m{sup 2}. The floor heating coil pipes were made of high-quality pure copper with the dimension of {phi} 12 x 0.7 mm. Under typical weather condition of Shanghai, the average heating capacity was 25.04 kW during the working hours from 9:00 to 17:00, which was sufficient to keep indoor thermal environment. The average electric COP of the floor heating system was 19.76 during the system operation. Compared with the widely used air-source heat pump heating systems with the electric COP of 3.5 in Shanghai, the solar-powered floor heating system shows great potential in energy conservation in winter. With respect to the whole heating period, the solar fraction was 56%. According to the performance analysis of the system with ambient parameters, ...
One of the main requirements to use Be as a candidate for plasma facing component in ITER is providing a reliable joint between Be and Cu-alloy heat sink structure. In this work authors present the results of recent activity on this way. To create Be/CuCrZr joints the unique fast e-beam brazing technology was developed in Russia. The numbers of Be/CuCrZr mock-ups were manufactured in Efremov Institute by fast e-beam brazing using Cu-Sn-In-Ni brazing alloy. These mock-ups were tested by Sandia Laboratory at the EBTS electron beam facility. The goals of the tests were to define the allowable dimensions of the armour tiles for the heat loads of more than 10 MW/m{sup 2}, to find the limit of bond strength for the Be/CuCrZr joint and response to heat loads and to estimate the life time of the brazed tiles by thermo-cyclic testing. The screening and thermal fatigue results are presented. With the aim to check the applicability of developed fast brazing process to DS-Cu alloy ...
Basic information on photovoltaic conversion technology is provided for those unfamiliar with the field. Various types of photovoltaic products and systems currently available off-the-shelf are described. These include products without batteries, battery chargers, power packages, home electric systems, and partial systems. Procedures are given for designing a photovoltaic system from scratch. A few custom photovoltaic systems are described, and a list is compiled of photovoltaic firms which can provide custom systems. Guidance is offered for deciding whether or not to use photovoltaic products. A variety of installations are described and their performance is appraised by the owners. Information is given on various financial incentives available from state and federal governments. Sources of additional information on photovoltaics are listed. A matrix is provided indicating the sources of various types of photovoltaic products. The addresses of suppliers are listed. ...
Stability and decomposition of PtSi, NiSi, and PdSi in contact with single crystal or amorphous Si is examined. PtSi, PdSi and NiSi are thermally stable both with Si, but are unstable in contact with metal film. It is shown that epitaxial Si layers can be obtained using both Pd and Al as metal film and layers can be electrically doped by the addition of a doping layer to the thin film structure prior to the heat treatment or by inclusion of Al atoms so that n/sup +/ and p/sup +/ conductivity can be achieved in the grown epilayer. The effects of impurities, substrate orientation on the growth kinetics are also discussed. (LEW)
Progress made during the first phase effort of the Solar-Thermal Full-System Experiment is summarized. This is one of a number of projects in the Solar-Thermal Subprogram involved with the development of solar central receiver hardware and systems for future use by utilities. The main emphasis is on systems that use Brayton-Cycle (gas turbine) equipment. The project summarized involves the planning and design of a complete Brayton-Cycle solar central receiver experimental system that would include all components of a commercial-size electric utility solar power plant. The objective of the overall project is to demonstrate the technical feasibility of a complete Brayton-Cycle, solar-fossil hybrid central receiver system. Major objectives of the Phase I effort summarized are to plan and design the experiment in detail and to organize a utility Test and Operating Group that would be directly involved in the development and operation of the experiment. (LEW)
Time contour expression of limited range phenomena on stack chart is examined for further improvement on the result of the ultimate interpretation in the seismic reflection survey. The policy is made clear from the beginning that local phenomena are to be discussed, and data prior CMP stacking is interpreted in detail. For this purpose, it is effective to make use of the time contour expression in the midpoint-offset plane simultaneously with the CMP and COP panels. For the review of data prior to CMP stacking, it is convenient to use the CMP (CDP) stacking chart in which the data is arranged methodically. In this chart, all the channels which are crude data prior to stacking are plotted on midpoint-offset coordinates, which plane is called the MOD (Midpoint Offset Domain) panel. Various panels can be chosen unrestrictedly, and their mutual relations can be easily grasped. When data points are given a time axis, they can be expressed in a time contour. Studies are ...
This paper presents an analysis of the applicability of alternative systems for electric vehicle (EV) heating and air conditioning (HVAC). The paper consists of two parts. The first part is a cooling and heating load calculation for electric vehicles. The second part is an evaluation of several systems that can provide the desired cooling and heating in EVs. These systems are ranked according to their overall weight The overall weight is calculated by adding the system weight and the weight of the battery necessary to provide energy for system operation. The system with the minimum overall weight is considered to be the best, because minimum vehicle weight decreases the energy required for propulsion, and therefore increases the vehicle range. Three systems are considered as the best choices for EV HVAC. These are, vapor compression, ice storage and adsorption systems. These systems are evaluated, including calculations of system weight, system volume, and COP. The ...
Geothermal energy resources are found in many countries. A reasonable and efficient utilization of these resources has been a worldwide concern. The application of geothermal heat pump systems (GHPS) can help increase the efficiency of using geothermal energy and reduce the thermal pollution to the earth surface. However, this is only possible with a proper working fluid. In this paper, a non-azeotropic working fluid (R290/R600a/R123) is presented for a GHPS where geothermal water at 40-45{sup o}C and heating network water at 70-80{sup o}C serve as the low and high temperature heat sources. Experimental results show that the coefficient of performance (COP) of a GHPS using the working fluid is above 3.5 with the condensation temperature above 80{sup o}C and the condensation pressure below 18 bar, while the temperature of the geothermal water is reduced from 40-46{sup o}C to 31-36{sup o}C. (author)
Geothermal energy resources are found in many countries. A reasonable and efficient utilization of these resources has been a worldwide concern. The application of geothermal heat pump systems (GHPS) can help increase the efficiency of using geothermal energy and reduce the thermal pollution to the earth surface. However, this is only possible with a proper working fluid. In this paper, a non-azeotropic working fluid (R290/R600a/R123) is presented for a GHPS where geothermal water at 40-45 deg. C and heating network water at 70-80 deg. C serve as the low and high temperature heat sources. Experimental results show that the coefficient of performance (COP) of a GHPS using the working fluid is above 3.5 with the condensation temperature above 80 deg. C and the condensation pressure below 18 bar, while the temperature of the geothermal water is reduced from 40-46 deg. C to 31-36 deg. C.
The merits of single stage absorption heat pumps coupled to simple distillation for effluent treatment are discussed. An experimental integrated absorption heat pump effluent purification system (IAHPEPS) was built and operated with water-lithium bromide as a working mixture. This unit has been used to raise the temperature and hence, the vapour pressure of the impure water contained in one vessel, to the point where pure water vapour will distil from impure effluent solution (tap water or brine) and condense in a second vessel used to collect pure water. Pure effluent production rates of between 0.5 and 4.3 kg h{sup -1} were obtained. The actual coefficient of performance (COP{sub A}) and the heat pump effectiveness varied from 1.1 to 1.4 and 0.58 to 0.72, respectively. The results from the small scale systems indicate the likely results from industrial scale units which could be operated with low quality heat such as waste heat, solar or geothermal resources. ...
Laser-assisted processing techniques for producing high-quality solar cell metallization patterns are being investigated, developed, and characterized. A literature search was carried out on the various state-of-the-art laser-assisted techniques for metal deposition, including laser chemical vapor deposition and laser photolysis of organometallics, as well as laser-enhanced electroplating. The results of the literature survey are briefly summarized. Experiments were carried out on laser-enhanced electroplating. Deposition of metals by laser-assisted pyrolysis of a variety of metallo-organic inks and metal-bearing polymer solutions spun as films onto silicon wafers was carried out. A detailed study of the various models of localized surface temperature rise in silicon due to laser heating has been carried out. Progress is reported in fabricating laser-metallized solar cells with improved efficiencies. Cells fabricated are characterized. A preliminary economic evaluation of laser-writing ...
The work reported is to evaluate two alternative resource recovery systems which would produce a fuel or an energy product (steam) for sale to an industrial plant. The first alternative is a refuse derived fuel (RDF) production facility which would process waste to produce fuel for sale to the plant. The RDF would be co-fired with coal in new boilers. The second alternative is a mass burn steam generation facility which would produce high pressure superheated steam for sale. The steam would be used by the plant to cogenerate electricity and for the process. Conceptual designs are developed for each alternative to form the basis of estimates of capital and operating costs and potential energy revenues. Operating requirements are developed for both alternatives. An assessment is made of the impact of both alternatives on the environment, and it is concluded that the impact of either alternative will be negligible. Order of magnitude estimates are made of capital and operating costs. The ...
At COP3 in 1997, an agreement was made to the innovative technical development/promotion by international cooperation, and the promotion of transfer of environmental technology to developing countries. Under the agreement, a feasibility study of international cooperation was made, and especially a study was conducted of the utilization/development of solar energy by the innovative solar thermochemical process. The main reason for global warming is emissions of a large amount of CO2 caused by the direct combustion of fossil fuels. Therefore, a CO2 recycle system taken up in the study enables a more substantial decline in CO2 emission (kg/kWh) per unit generation than the conventional thermal power system by composing solar methanol or solar dimethyl ether using fossil fuels including coal, water, CO2, etc. as raw materials and using solar energy as heat source, and by using this as fuel (solar fuel). CO2 can be reduced by 13% to 14% by substituting solar methanol or ...
Global environment problems have become more and more serious in recent years, and reduction of greenhouse gas emission based on Kyoto Protocol adopted at the 3rd conference of the parties of the United nations Framework Convention on Climate Change (COP3); securement of primary energy source and development of clean and renewable energy sources have been pressingly needed in consideration of the predicted depletion of fossil fuel in the future. In this study, we explore the use of a solidified biomass-derived fuel, having the maximum compressive strength of 100MPa and calorific value of 21MJ/kg, in iron-casting or iron-making processes as an alternative fuel to be mixed with coal coke. This study, carried out for internal observation using a quick-freeze technique, observed an actual working cupola furnace under the 20% alternative coal coke operation condition. After quick freeze of the cupola furnace, the solidified biomass fuel was found to inhabit near the ...
A parallel event to the eleventh Conference of Parties (COP) to the United Nations Framework Convention of Climate Change was held to demonstrate examples of adaptation from around the world in the areas of food security, water resources, coastal zones, and communities/infrastructure. Panels on each theme presented examples from developing countries, countries in economic transition, and developed countries. These 4 themes were chosen because both mitigation and adaptation are essential to meeting the challenge of climate change. The objective of the event was to improve the knowledge of Canada's vulnerabilities to climate change, identify ways to minimize the negative effects of future impacts, and explore opportunities that take advantage of any positive impacts. This third session focused on how coastal communities are adapting to climate change in such places as Quebec, the Caribbean, and small Island States. It also presented the example of how a ...
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