WorldWideScience
 
 
1

Nutritional Biomarkers in Children and Adolescents with Beta-Thalassemia-Major: An Egyptian Center Experience  

Science.gov (United States)

Background and Aim. Trace elements and vitamins play a vital role in human body to perform its function properly. Thalassemic patients are at risk of micronutrient deficiency. This study estimated levels of vitamins A, C, E, B12, folic acid, total homocysteine (tHcy), and methylmalonic acid (MMA) along with trace elements, zinc, copper, and selenium in Beta-thalassemia-major patients. Methods. This study included 108 patients with Beta-thalassemia-major and 60 age and sex matched healthy children. Serum levels of vitamin A, E, C, tHcy, and MMA were estimated by high pressure liquid chromatography while serum levels of folic acid and B12 were estimated by thin layer chromatography. Serum zinc, copper, and selenium were determined by atomic absorption spectrometry. Results. There was a significant decrease of vitamins A, C, E, and B12 and trace elements zinc, copper, and selenium in thalassemic patients as compared to controls. tHcy and MMA were significantly elevated in patients. No significant correlations were found between the serum levels of the studied vitamins and trace elements as regards age, frequency of transfusion, duration of transfusion, and serum ferritin. Conclusion. The level of various nutritional biomarkers (vitamins A, C, E, and B12 and trace elements zinc, copper, selenium) was reduced in chronically transfused Egyptian thalassemic patient. These patients should have periodic nutritional evaluation and supplementation. Multicenter studies are highly recommended.

Sherief, Laila M.; Abd El-Salam, Sanaa M.; Kamal, Naglaa M.; El safy, Osama; Azab, Seham F.; Morsy, Hemat M.; Gharieb, Amal F.

2014-01-01

2

Hematuria in Patients With Beta-Thalassemia Major  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Introduction. Our information about renal involvement in beta-thalassemia major is limited. Recently, few studies have reported proteinuria, hypercalcuria, phosphaturia, and oversecretion of tubular damage markers; however, hematuria has not yet been meticulously studied in these patients. We investigated hematuria in patients with beta-thalassemia major.Materials and Methods. Urinalysis was performed in 500 patients with beta-thalassemia major under a regular blood transfusion prog...

Mohammad Hossein Fallahzadeh; Mohammad Kazem Fallahzadeh; Mehdi Shahriari; Shervin Rastegar; Ali Derakhshan; Mohammad Amin Fallahzadeh

2010-01-01

3

Malocclusion in subjects with beta-thalassemia major  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Introduction: Beta-thalassemia major is a hemolytic anemia. If these patients are not treated, bone marrow hyperplasia will happen. Hematopoiesis in the jaw results in mandibular and/or maxillary enlargement. To our knowledge, there are few studies about frequency of malocclusion in these patients. Therefore, this study was designed to investigate the frequency of malocclusion in beta-thalassemia patients and compare it to healthy control group. Materials and Methods: This research was a cross sectional study. Seventy beta-thalassemia patients and 70 healthy controls (age and sex matched were examined for malocclusion using Angle classification, WHO malocclusion classification, determination of overjet and overbite. If crossbite, spacing, openbite, crowding and mouth breathing were observed in clinical examination they were recorded. Statistical analysis was done using Chi-square and Variants analysis. Results: Beta-thalassemia patients showed class II malocclusion (angle classification and grade 2 (WHO classification more than healthy control group. There were significant differences in angle & WHO malocclusion classification between two groups (P<0.05. Increased overjet and mouth breathing were seen in patients more than healthy control group. There were significant differences in overjet and mouth breathing between two groups (P<0.05. There was a positive correlation between WHO malocclusion classification and serum ferritin levels, but not between angle malocclusion classification, overjet and serum ferritin levels. Conclusion: Beta-thalassemia major is associated with increased malocclusion and these anomalies will occur if the patients are not treated early. Patients with malocclusion should be visited and followed up by a dentist for dental problems. Fortunately, as a result of new treatments these patients live longer than before. Therefore, it is important to pay attention to their functional and esthetical problems.

F. Shahsevari

2007-08-01

4

Hypoparathyroidism in Adult Patients with Beta-Thalassemia Major  

Science.gov (United States)

Objective: To evaluate the prevalence of hypoparathyroidism in adult transfusion-dependent patients with beta-thalassemia major in a teaching referral hospital in Oman. Methods: All adult (>13 years) patients with beta-thalassemia major seen at Royal Hospital in Oman between 2004 and 2006 were studied. Demographic, pharmaceutical, clinical and biochemical data were collected for all the subjects. Analyses were performed using both descriptive and univariate statistics. Results: A total of 31 patients were included into the study with an overall mean age of 19±3 years ranging from 14 to 30 years. Just over half of the subjects were males (n=16; 52%). All the patients were on hypertransfusion and combined chelation therapy with desferrioxamine 40–60 mg/kg 5 days per week and deferiprone 75 mg/kg/day. Three of the patients had low levels of parathyroid hormone (<1.6 pmol/l). A further three patients had normal levels of parathyroid hormone (1.6 – 9.3 pmol/l) in the presence of low serum calcium levels (<2.1 mmol/l). These patients (with normal hypoparathyroid hormone levels, but lower calcium levels) were also defined to have hypoparathyroidism bringing the total prevalence of hypoparathyroidism in this cohort of adult patients with Beta-thalassemia major to 19% (6 out of 31). The patients with hypoparathyroidism had statistically significantly lower levels of parathyroid hormone (2.7 versus 5.3 pmol/l; p=0.031) and serum calcium (1.7 versus 2.3 pmol/l; p=0.004) compared to those without hypoparathyroidism. Conclusion: The prevalence of hypoparathyroidism in adult beta-thalassemia major patients at this referral center was significantly higher (19%) than those reported elsewhere (2.5 and 10.7%).

Sleem, Gihan Ali A M; Al-Zakwani, Ibrahim S; Almuslahi, Muhanna

2007-01-01

5

Hematuria in Patients With Beta-Thalassemia Major  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction. Our information about renal involvement in beta-thalassemia major is limited. Recently, few studies have reported proteinuria, hypercalcuria, phosphaturia, and oversecretion of tubular damage markers; however, hematuria has not yet been meticulously studied in these patients. We investigated hematuria in patients with beta-thalassemia major.Materials and Methods. Urinalysis was performed in 500 patients with beta-thalassemia major under a regular blood transfusion program. In those with hematuria (at least 3 to 5 erythrocytes per high-power field a second urinalysis was done at the next transfusion time.Results. The patients ranged in age from 6 months to 32 years. The male-female ratio was 1.05:1. Hematuria was detected in 55 (10.6%, including 9.8% of those younger than 20 years and 20.0% of those older than 20 years. Hematuria was persistent in 79.2% of the second urinalyses. Sixty-four percent of the patients with hematuria were females. A blood transfusion program had been started during the first year of life in 81% percent of the patients with hematuria. Sterile pyuria was detected in 4% and proteinuria in 16% of the patients with hematuria, while these figures in patients without hematuria were 2.1% (P = .56 and 1.4% (P = .002, respectively.Conclusions. We found that in patients with beta-thalassemia major, the risk of hematuria rises with age. Moreover, proteinuria seems to be more common in those with hematuria. Further studies are needed to ascertain the importance of these findings.

Mohammad Hossein Fallahzadeh

2010-04-01

6

Assessment of Hypothyroidism in Children with Beta-Thalassemia Major in North Eastern Iran  

Digital Repository Infrastructure Vision for European Research (DRIVER)

AbstractBackground Hypothyroidism usually appears in the second decade of life and is thought to be associated with iron overload in patients with thalassemia major. This study aimed to evaluate thyroid dysfunctions in patients with beta-thalassemia major.Materials and MethodsThis research is a descriptive – cross sectional study, carried out in 2009 to assess thyroid function in 100 patients with beta thalassemia major at the ages between 2-18 years. The study was carried out retrospectiv...

2012-01-01

7

Economic burden of beta-thalassemia/Hb E and beta-thalassemia major in Thai children  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Hemoglobin E beta-thalassemia (?-thalassemia/Hb E has a variable severity, and the cost of treatment has not been well studied. The aim of this study was to analyze the societal cost of caring for children with ?-thalassemias in Thailand. The study was designed as a prevalence-based cost-of-illness analysis in a societal perspective. Medical records from three public hospitals of children aged 2-18 years with ?-thalassemia/Hb E and homozygous ?-thalassemia were reviewed for direct medical cost determination. For direct non-medical cost and indirect cost, a family member was interviewed. Findings It was found that 201 patients with ?-thalassemia/Hb E (91% and homozygous ?-thalassemia (9% were recruited for this study. Ninety-two (46% were severe thalassemia and 109 (54% were mild to moderate severity. The annual average cost of treatment was US$950; 59% was direct medical cost, 17% direct non-medical cost, and 24% indirect cost. The costs were differentiated by some potential predictors. Significant predictor variables were: hospital, health insurance scheme, blood transfusion pattern, and iron chelation drug use. Conclusions The average annual cost per patient was calculated, and the cost model was estimated. These would be applied for national planning, economic evaluation of treatment and prevention interventions, and budget impact analysis.

Riewpaiboon Arthorn

2010-01-01

8

Evaluation of Mental Health and Related Factors Among Patients with Beta-Thalassemia Major in South East of Iran  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective: Beta-thalassemia major (?-TM) is a chronic, genetic and hematological disorder. Children and teenagers with chronic physical illnesses exemplified by thalassemia are vulnerable to emotional and behavioral problems. The aim of this study was to evaluate mental health and its related factors among young patients with beta-thalassemia major. Methods: In this cross-sectional observational descriptive-analytic study, we studied 164 patients suffering from Beta-thalassemia major wit...

Majid Naderi; Mohammad Reza Hormozi; Morteza Ashrafi; Abolfazl Emamdadi

2012-01-01

9

Evaluation of pulmonary function in beta-thalassemia major patients  

International Nuclear Information System (INIS)

Objective: To describe and quantify the functional change of the lung in patients with beta-thalassemia major (TM) and determine the correlation between pulmonary function test (PFT) results with hemoglobin, ferritin and age changes. Methodology: Pulmonary function tests were performed on 60 transfusion-dependent patients with TM, ranging in age from 10 to 45 years. Percent-predicted values for forced expiratory volume in one second (FEV1), and forced expiratory flows (FEF) 25-75% were significantly reduced, whereas forced expiratory vital capacity (FVC) and FEV1/FVC were closed to normal limits, indicating a restrictive disease. All factors including; FVC, FEV1, and FEV1/FVC, FEF 25-75% were negatively correlated with age and ferritin levels. In contrast, all factors including; FVC, FEV1, and FEV1/FVC, FEF 25-75% were positively correlated with hemoglobin (Hb). We performed linear regression analysis to study the simultaneous influence of the presence of age, ferritin, and Hb on obstructive PFT indexes. Results: Pulmonary function test results were normal in only 32 (53.3%) of 60 patients and the rest 28 cases (46.7%) showed abnormal pulmonary function. FEV1 and FEF 25% - 75% have significant negative correlation with age (r = - 0.64 p(r) = 0.003 and r = - 0.58 p(r) = 0.02 respectively), also have significant positive correlation with Hb (r = 0.31 p(r) = 0.015 and r = 0.33 p(r) = 0.01 respectively), and only FEF 25% - 75% has significant negative correlation with ferritin (r -0.26 p(r) = 0.04). Conclusion: The present study has shown that restrictive disease and reduced lung diffusing capacity are the predominant abnormalities of pulmonary function patients with TM. The low hemoglobin concentration and a fall in the diffusing capacity of the alveola - capillary membrane, together with the dependence of the reduced pulmonary diffusing capacity on age and serum ferritin levels, as well as of the entity of restrictive disease on age, suggests that pulmonary dysfunctions in patients with TM are due mainly to lung fibrosis and/or interstitial edema related to iron overload. (author)

2010-01-01

10

Major Causes of Hospital Admission in Beta Thalassemia Major Patients in Southern Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Beta thalassemia major is a prevalent hereditary disease in Mediterranean region especially Iran. Early blood transfusion is necessary for most of the patients and frequent transfusion can cause various medical problems for the patients. The aim of this study was to find major causes of hospital admission in beta thalassemia major patients to reach the accurate preventive and therapeutic plans for these patients.Methods: Four hundred twenty six patients were admitted to the Nemazee Hospital (the main University referral Hospital Center affiliated to Shiraz University of Medical Sciences in Fars Province, southern Iran during 3 years period (January 2007 to January 2010. A questionnaire was filled containing age, gender, hemoglobin level, frequency of blood transfusions, deferoxamine injection, cause of hospital admission and hospital course.Findings: The mean age of patients was 11.28 years. The mean serum ferritin level was 1820±749 ?g/lit. Two hundred fifty five (59.75% patients were male and 171 (40.25% patients were female. The top five most prevalent causes of hospital admission were splenectomy (21.8%, infections (19.9%, congestive heart failure (19.0%, diabetes mellitus (13.4%, and Liver biopsy (11.5%. (P=0.0002Conclusion: Results of this study revealed that infections and complications due to iron overload are major causes of hospital admission in beta thalassemia major patients.

Mehran Karimi

2011-12-01

11

Major Causes of Hospital Admission in Beta Thalassemia Major Patients in Southern Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Beta thalassemia major is a prevalent hereditary disease in Mediterranean region especially Iran. Early blood transfusion is necessary for most of the patients and frequent transfusion can cause various medical problems for the patients. The aim of this study was to find major causes of hospital admission in beta thalassemia major patients to reach the accurate preventive and therapeutic plans for these patients.Methods: Four hundred twenty six patients were admitted to the Nemazee Hospital (the main University referral Hospital Center affiliated to Shiraz University of Medical Sciences in Fars Province, southern Iran during 3 years period (January 2007 to January 2010. A questionnaire was filled containing age, gender, hemoglobin level, frequency of blood transfusions, deferoxamine injection, cause of hospital admission and hospital course.Findings: The mean age of patients was 11.28 years. The mean serum ferritin level was 1820±749 µg/lit. Two hundred fifty five (59.75% patients were male and 171 (40.25% patients were female. The top five most prevalent causes of hospital admission were splenectomy (21.8%, infections (19.9%, congestive heart failure (19.0%, diabetes mellitus (13.4%, and Liver biopsy (11.5%. (P=0.0002.Conclusion: Results of this study revealed that infections and complications due to iron overload are major causes of hospital admission in beta thalassemia major patients.

Jacob Hoseini

2011-12-01

12

Beta Thalassemia Major in a Developing Country: Epidemiological, Clinical and Evolutionary Aspects  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Beta-thalassemia major (TM) remains to be one of the major health problems particularly in developing countries. Tunisia is a part of the Mediterranean countries mostly affected by this disease which is highly concentrated in small towns in families with low-income earners. The main objectives of this study are to provide a description of the demographic, clinical features and transfusion-related complications in patients with TM living in Tunisia. A standardized questionnaire was sent to cli...

2013-01-01

13

Side effects of Deferasirox Iron Chelation in Patients with Beta Thalassemia Major or Intermedia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objectives: Chelating agents remain the mainstay in reducing the iron burden and extending patient survival in homozygous beta-thalassemia but adverse and toxic effects may increase with the institution and long term use of this essential therapy. This study aimed to estimate the incidence of deferasirox (DFX) side effects in patients with thalassemia major or intermedia.Methods: A retrospective study of 72 patients (mean age: 20.3±0.9 yrs; 36 male, 36 female) with thalassemia major or inter...

Murtadha Al-Khabori; Sunil Bhandari; Mohammed Al-Huneini; Khalil Al-Farsi; Vinodh Panjwani; Shahina Daar

2013-01-01

14

Psychological Aspects in Young Adults with Beta-Thalassemia Major, control group  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background and purpose: Beta-thalassemia major (TM), a chronic, genetically determined hematological disorder, has received little investigation on the psychological aspects of the disease and the psychosocial adjustment of patients with this anemia. In the present study, the aim was to explore the nature of psychopathology according to age, sex, school performance, severity and complications of the disease in TM patients compared with demographically matched healthy persons.Materials and Met...

2007-01-01

15

Assessment of Thyroid Function in Children Aged 1-13 Years with Beta-Thalassemia Major  

Directory of Open Access Journals (Sweden)

Full Text Available Objective:Hypothyroidism usually appears in the second decade of life and is thought to be associated with iron overload in patients with thalassemia major. This study aimed to evaluate thyroid dysfunctions in patients with beta-thalassemia major and to see if they appear in the earlier period of life. Methods:Thyroid function and iron load status were evaluated in 90 children with a mean age of 7.17±3.78 years with beta-thalassemia major by measuring serum free thyroxin (FT4, serum free triiodothyronine (FT3, total thyroxin (T3, serum total triiodothyronine (T4, thyroid-stimulating hormone (TSH and ferritin levels from serum of patients admitted to the Pediatric Department, Faculty of Medicine University of Dicle between March 2005 and July 2009. A control group formed from an age-sex matched healthy children with a mean age of 6.98±3.66 years was also included. A standard thyrotropin releasing hormone test was applied to 3 patients who had high TSH levels and were classified as subclinical primer hypothyroidism. The study was designed according to the Declaration of Helsinki and informed consent was obtained from the parents of all participants. Findings:All thyroid parameters in patients were in the normal ranges compared with the controls except three of them which had high TSH levels. Serum ferritin level (2703±1649 ng/mL in patients was significantly higher than in controls (81.5±15.5 ng/mL. Conclusion:The work implies that hypothyroidism could be even seen in the first decade of life in patients with beta-thalassemia major in spite of improved hematological cares.

Nurcan Beyaz?t

2011-03-01

16

Assessment of Thyroid Function in Children Aged 1-13 Years with Beta-Thalassemia Major  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Hypothyroidism usually appears in the second decade of life and is thought to be associated with iron overload in patients with thalassemia major. This study aimed to evaluate thyroid dysfunctions in patients with beta-thalassemia major and to see if they appear in the earlier period of life.Methods: Thyroid function and iron load status were evaluated in 90 children with a mean age of 7.17±3.78 years with beta-thalassemia major by measuring serum free thyroxin (FT4, serum free triiodothyronine (FT3, total thyroxin (T3, serum total triiodothyronine (T4, thyroid-stimulating hormone (TSH and ferritin levels from serum of patients admitted to the Pediatric Department, Faculty of Medicine University of Dicle between March 2005 and July 2009. A control group formed from an age-sex matched healthy children with a mean age of 6.98±3.66 years was also included. A standard thyrotropin releasing hormone test was applied to 3 patients who had high TSH levels and were classified as subclinical primer hypothyroidism. The study was designed according to the Declaration of Helsinki and informed consent was obtained from the parents of all participants.Findings: All thyroid parameters in patients were in the normal ranges compared with the controls except three of them which had high TSH levels. Serum ferritin level (2703±1649 ng/mL in patients was significantly higher than in controls (81.5±15.5 ng/mL.Conclusion: The work implies that hypothyroidism could be even seen in the first decade of life in patients with beta-thalassemia major in spite of improved hematological cares.

Ayfer Gozu Pirinccioglu

2011-03-01

17

Ambulatory Blood Pressure Monitoring for Children With Beta–Thalassemia Major: a Preliminary Report  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction. Heart disease is one of the most common reasons of death in beta-thalassemia major. A few studies have been done in children about blood pressure changes. The aim of this study was to assess hemodynamic changes by ambulatory blood pressure monitoring (ABPM. Materials and Methods. In this cross-sectional study, 30 patients with beta-thalassemia major aged 5 to 18 years old were evaluated with 24-hour ABPM. The exclusion criteria were an ejection Fraction less than 50% and a glomerular filtration rate less than 90 mL/min/1.73 m2. Hypertension was defined as a mean blood pressure index of 1 and greater with or without load blood pressure greater than 25%. Dipper status was defined as a 10% decrease in nighttime versus daytime mean arterial blood pressure. Results. High blood pressure was detected in 16.7% of the patients. The whole-day ABPM showed hypertension in 6.7% of the children. During daytime measurements, systolic hypertension was seen in 3.3% (load 3.7% and diastolic in 6.7% (load 3.3%. These figures for nighttime evaluation were 6.7% (load 3.3% and 10.3% (load 6.9%, respectively. Nondipper status was detected in 56.7% of the children. There was no significant correlation between abnormal blood pressure and age, sex, body mass index, hemoglobin, number or rates of blood transfusion, or serum ferritin level. Conclusions. The ABPM may be a useful instrument for early detection of hemodynamic changes in children with beta-thalassemia major.

Morteza Tabatabaie

2013-07-01

18

Peripheral Blood Stem Cell Transplantation in Patients with Beta-Thalassemia Major  

Digital Repository Infrastructure Vision for European Research (DRIVER)

From 1996 to 2002, fifty three patients with major beta-thalassemia received allogeneic peripheral blood stem cell trans¬plantation (PBSCT). Median age was 6 years .Twenty two were class I, 17 class II and 14 class III. All of the donors were HLA-identical. Conditioning regimen for class I and II patients consisted of Cyclophosphamide (CY) 50 mg/kg/day for 4 days + Busulfan (Bu) 3.5 mg/kg for 4 days, while class III patients received 4 mg/kg/day Busulfan for 4 days and 40mg/kg/day Cycloph...

2004-01-01

19

Frequency of Celiac Disease in Children with Beta Thalassemia major  

Science.gov (United States)

Background We aimed to investigate the frequency of celiac disease in children with ?-thalassemia major (B-TM) in Shiraz, southern Iran. Materials and Methods In this study, the prevalence of celiac disease in children with B-TM was evaluated. Children with B-TM were screened for celiac disease by ant-tissue transglutaminase (anti-tTG) IgA antibody, IgA level and anti-tTG IgG. A total of 1500 school healthy children in Shiraz with age/sex matched were selected as control group. Results A total of 215 B-TM patients with mean age of 12.7 ± 4.4 years, were included into the study (52.1% was male). None of the patients were positive for anti-tTG IgA. Eight cases were IgA deficient in whom anti-tTG IgG was investigated but none of them were positive for anti-tTG IgG. The finding in control group has a seroprevalence of 2% and biopsy proven disease of 0.6%. Conclusion Many patients with thalassemia major have multiple non specific symptom that are not justifiable with underlying disease and might be due to atypical celiac disease. We didn't find any case of celiac disease among more than 200 children with ?-thalassemia major in Shiraz, southern Iran. So it seems reasonable to screen only those who have features, even not classical, of celiac disease.

Honar, N; Kamali, S; Karimi, M

2014-01-01

20

Frequency of hepatitis B and hepatitis C in multi - transfused beta thalassemia major patients  

International Nuclear Information System (INIS)

To determine the frequency of hepatitis B and C virus infection among children with beta thalassemia major registered at Military Hospital Rawalpindi. Children attending Thalassemia Centre Military Hospital Rawalpindi for regular blood transfusion were registered. They belonged to different ethnic groups and came from different parts of the country. Their demographic data was recorded, detailed history taken and physical examination was carried out. Their serum samples were tested for hepatitis B surface antigen and anti HCV antibody assay with third generation commercial ELISA method. During the study; 141 patients of beta thalassemia major were screened. Out of them 50 patients (35.5% ,95% confidence interval 27.8-43.5)w ere found hepatitis C virus antibody positive and 1 patient (0.7 %) hepatitis B surface antigen positive. One patient (0.7%) had both hepatitis B and C virus infection. Mean age of hepatitis C infected patients was 10.4+3.85y ears (range 2-16 years). Mean age of uninfected patients was 6.1 + 3.59 years. (p value 0.000) In addition, the results indicate that higher prevalence of anti-HCV was significantly associated with longer duration of transfusion (p value <0.003). In spite of the fact that screened blood is used for transfusions, still a large number of patients have been found infected with hepatitis C. Therefore more accurate techniques are required for screening of blood to prevent transfusion associated transmission. (author)

2010-06-01

 
 
 
 
21

Hypoparathyroidism and intracerebral calcification in patients with beta-thalassemia major  

International Nuclear Information System (INIS)

Background: Hypoparathyroidism is one of the most important endocrine complications of thalassemia major. This study was conducted to evaluate the prevalence of intracerebral calcifications in patients with thalassemia with and without hypoparathyroidism. Methods: 47 beta-thalassemia patients with hypoparathyroidism underwent a brain CT scan to investigate the presence and extent of intracerebral calcification. 30 age- and sex-matched beta-thalassemic patients with normal parathyroid function who had undergone brain CT for headache, or some other minor neurologic problems were also enrolled in the study serving as controls. The amount of intracerebral calcification, hematologic parameters, and some clinical findings were compared between both groups. Results: Intracerebral calcification was present in 54.2% of beta-thalassemia patients with hypoparathyroidism. The most frequent sites of calcification were basal ganglia, and frontoparietal areas of the brain. Thalami, internal capsule, cerebellum and posterior fossa were other less frequently calcified regions of the brain. In contrast, there was no evidence of intracerebral calcifications in the 30 thalassemic patients with normal parathyroid function. There was not a statistically significant difference between serum ferritin concentrations in thalassemia patient with hypoparathyroidism and those with normal parathyroid function (2781 vs. 2178, P > 0.05). Conclusion: Intracranial calcification is a common finding in thalassemia patients with hypoparathyroidism, it can be extensive and involves most regions of the brain.

2009-06-01

22

EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR  

Directory of Open Access Journals (Sweden)

Full Text Available Peripheral blood T lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years and compared with 14 age-arid sex-matched healthy controls. Three monoclonal antibodies (anti-CD3, anti CD-f, unti-CDS were simultaneously applied for detection of Th (CD3-, CD4^, Tsk (CD3+, CD8+ and Th/Ts ratio by flow-cytometry respectively. The results of this study showed a slight increase in the number of Tlymphocytes, T 004^, TCDS+, and CD4'*/CDS* ratio; but this increase was not statistically significant (P>0.05. No primary defect in Tcell subsets was detected and it was suggested that continuous regulation of iron balance is an important factor in decreasing immunological disturbance.

A. Danesh

1999-07-01

23

The effect of repeated transfusions on immunoglobulins levels and complement components in Beta Thalassemia major patients  

Directory of Open Access Journals (Sweden)

Full Text Available Beta Thalassemia major patients receive repeated transfusions in order to compensate anemia and use desferal to remove iron overload. Comparing immunoglobulins and complement components in the serum of these patients with normal range shows a significant increase (P<0.001 in IgG, IgA and IgM and a decrease in C3c and C4. The regression analysis confirms a relation between the numbers of transfusions and the mentioned immunological factors that means increasing the number of transfusions, increases immunoglobulins and decreases the complement. Also, this evaluation shows that use of washed RBC and regular in take of desferal will prevent excessive increase of immunoglobulins or decrease of complement

Mehrabani K

1996-06-01

24

Peripheral Blood Stem Cell Transplantation in Patients with Beta-Thalassemia Major  

Directory of Open Access Journals (Sweden)

Full Text Available From 1996 to 2002, fifty three patients with major beta-thalassemia received allogeneic peripheral blood stem cell trans¬plantation (PBSCT. Median age was 6 years .Twenty two were class I, 17 class II and 14 class III. All of the donors were HLA-identical. Conditioning regimen for class I and II patients consisted of Cyclophosphamide (CY 50 mg/kg/day for 4 days + Busulfan (Bu 3.5 mg/kg for 4 days, while class III patients received 4 mg/kg/day Busulfan for 4 days and 40mg/kg/day Cyclophosphomide for 4 days. G-CSF (Neopogen 5µ/kg IV was given to donors. Graft Versus Host Disease (GVHD prophylaxis regimen consisted of Cyclosporin-A (CsA 3 mg/kg/day plus Methotrexate (MTX 10 mg/m2 on day+1 and 6 mg/m2 on days +3 and +6. The median time for neutrophil and platelet engraftment was day +16 and day +23 post transplantation, respectively. Chronic GVHD (cGVHD was observed in 30 patients (56%. Ten patients (18.8% died. Forty patients are well and transfusion independent. Median time of follow-up was 23 months. Recurrences have been seen at 3 pts, one patient 21 months, the other one 6 months and the last one 8 months after transplantation, who received Donor Lymphocyte infusion (DLI. Event free survival was 72% and overall survival was 80%. In conclusion, we suggest that PBSCT can be considered a safe and effective treatment for children with Beta-thalassemia major and cGVHD is tolerable and manageable in these patients.

Ghavamzadeh A

2004-08-01

25

Frequency of Sensory Neural Hearing Loss in Major Beta-Thalassemias in Southern Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Objective:The thalassemias are among the most common genetic disorders worldwide, occurring more frequently in the Mediterranean region. The aim of this study was to determined frequency of sensory-neural hearing loss in major ß- thalassemias transfusion dependent patients in south of Iran. Methods:A cross sectional study on 308 cases of major beta-thalassemia patients referring to Thalassemia Center of Shiraz University of Medical Sciences between 2006-2007 years. The diagnosis of ß- thalassemia major was based on clinical history, complete blood count and hemoglobine electrophoresis. Clinical data such as serum ferritin level, deferoxamine (DFO dose, mean daily doses of DFO (mg/kg and audiometric variables was recorded. Findings:Out of 308 cases, 283 (96.5% had normal hearing and 10 (3.5% sensorineural hearing loss. There was no statically significant difference between two groups regarding mean age, weight, age at the first blood transfusion, age at the first DFO infusion. Conclusion:We found the lowest incidence of sensorineural hearing loss in a large population of patients suffered from major thalassemia who received DFO. We show that DFO is not ototoxic at a low dose. When considering all related literature, as a whole there has been much critical misrepresentation about DFO ototoxicity.

Seyed-Taghi Heydari

2010-09-01

26

Molecular basis of transfusion dependent beta-thalassemia major patients in Sabah.  

Science.gov (United States)

Beta-thalassemia is one of the most prevalent inherited diseases and a public health problem in Malaysia. Malaysia is geographically divided into West and East Malaysia. In Sabah, a state in East Malaysia, there are over 1000 estimated cases of ?-thalassemia major patients. Accurate population frequency data of the molecular basis of ?-thalassemia major are needed for planning its control in the high-risk population of Sabah. Characterization of ?-globin gene defects was done in 252 transfusion dependent ?-thalassemia patients incorporating few PCR techniques. The study demonstrates that ?-thalassemia mutations inherited are ethnically dependent. It is important to note that 86.9% of transfusion-dependent ?-thalassemia major patients in Sabah were of the indigenous population and homozygous for a single mutation. The Filipino ?(0)-deletion was a unique mutation found in the indigenous population of Sabah. Mutations common in West Malaysia were found in 11 (4.3%) patients. Four rare mutations (Hb Monroe, CD 8/9, CD 123/124/125 and IVS I-2) were also found. This study is informative on the population genetics of ?-thalassemia major in Sabah. PMID:24369358

Teh, Lai Kuan; George, Elizabeth; Lai, Mei I; Tan, Jin Ai Mary Anne; Wong, Lily; Ismail, Patimah

2014-03-01

27

Frequency of Sensory Neural Hearing Loss in Major Beta-Thalassemias in Southern Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Objective:The thalassemias are among the most common genetic disorders worldwide, occurring more frequently in the Mediterranean region. The aim of this study was to determined frequency of sensory-neural hearing loss in major ß- thalassemias transfusion dependent patients in south of Iran.Methods:A cross sectional study on 308 cases of major beta-thalassemia patients referring to Thalassemia Center of Shiraz University of Medical Sciences between 2006-2007 years. The diagnosis of ß- thalassemia major was based on clinical history, complete blood count and hemoglobine electrophoresis. Clinical data such as serum ferritin level, deferoxamine (DFO dose, mean daily doses of DFO (mg/kg and audiometric variables was recorded.Findings:Out of 308 cases, 283 (96.5% had normal hearing and 10 (3.5% sensorineural hearing loss. There was no statically significant difference between two groups regarding mean age, weight, age at the first blood transfusion, age at the first DFO infusion.Conclusion:We found the lowest incidence of sensorineural hearing loss in a large population of patients suffered from major thalassemia who received DFO. We show that DFO is not ototoxic at a low dose. When considering all related literature, as a whole there has been much critical misrepresentation about DFO ototoxicity.

Abolhassan Faramarzi

2010-09-01

28

Psychological Aspects in Young Adults with Beta-Thalassemia Major, control group  

Directory of Open Access Journals (Sweden)

Full Text Available Background and purpose: Beta-thalassemia major (TM, a chronic, genetically determined hematological disorder, has received little investigation on the psychological aspects of the disease and the psychosocial adjustment of patients with this anemia. In the present study, the aim was to explore the nature of psychopathology according to age, sex, school performance, severity and complications of the disease in TM patients compared with demographically matched healthy persons.Materials and Methods: A controlled anterograde cohort study was conducted at the Thalassemia Unit of Boo-Ali Hospital from June 2003 to November 2005 in Sari, Iran. Psychological aspects were evaluated by the Persian version of symptoms checklist-90-revised questionnaire. Information on relevant demographic characteristics, school performance, severity and complications of the disease was collected by one of the investigators who had created the questionnaire.Results: 125 persons with TM completed the questionnaires and were compared with 125 controls and 250 totally. The mean age of the participants was 18.51± 2.0 years and with a range of 15-25 years. 132 (52.8% were female with equal family status, social and economic status. Patients group reported a significantly lower level of marital status (P<0.01, education level (P<0.0001, school performance (P<0.0001. TM patients were found to have significantly more psychiatric disorders than the control subjects with GSI: 1.16 ± 0.47 vs. 1.01 ± 0.6; (P<0.03, PSD: 54.99 ± 12.59 vs. 46.42 ± 18.76 (P<0.0001, and PSDI 2.02±1.02 vs 2.45 ± 2.22 (P<0.05. We recorded significant changes in the mean scores of somatization (P<0.0001, interpersonal sensitivity (P<0.0001, depression (P<0.003, anxiety (P<0.05 and psychoticism (P<0.03 in the TM patients as compared to the control subjects.Conclusion: These findings show that beta-thalassemia major patients are at risk for psychiatric symptomatology and need appropriate psychiatric consultation.

S. H. Hosseini, M.D.

2007-09-01

29

Abdominal Ultrasonographic Findings in Beta Thalassemia Major Patients in North of Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Objective: High prevalence of tha-lassemia in the North of Iran is a major challenge of medical practitioners in this area. To investigate the prevalence of abdominal ultrasound findings in these patients, the present study was conducted. Materials and Methods: Two hundred patients (92 girls and 108 boys, all suffering from Beta thalas-semia major with a mean age of 14.5 years (ranging from 5 to 34 years were included in the study. Ab-dominal ultrasound examination was performed by two radiologists between 2001 and 2005 to detect sonographic findings in these patients. Results: Hepatomegaly was presented in 75% of these patients and splenomegaly was detected in 46% of them while 45% of cases had undergone splenec-tomy. Total incidence of gall bladder stone formation was 14% (15.5% in females and 11.9% in males and it had a direct correlation with the patients’ age. Lymphadenopathy of portohepatic and celiac area was detected in 138 (68% patients. In 4 patients ul-trasound revealed portal vein thrombosis whereas in the other 4 cases, splenic extramedullary hematopoi-esis was detected. Conclusion: This study revealed that a remarkable portion of patients had developed these complica-tions. Authors suggest ultrasound to be a part of rou-tine examinations in beta thalassemia major patients who receive multiple transfusions.

R. Abdi

2007-05-01

30

Evaluation of Mental Health and Related Factors Among Patients with Beta-Thalassemia Major in South East of Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Beta-thalassemia major (?-TM is a chronic, genetic and hematological disorder. Children and teenagers with chronic physical illnesses exemplified by thalassemia are vulnerable to emotional and behavioral problems. The aim of this study was to evaluate mental health and its related factors among young patients with beta-thalassemia major. Methods: In this cross-sectional observational descriptive-analytic study, we studied 164 patients suffering from Beta-thalassemia major with age range of 15-24 years who referred for treatment to Ali Ebn-e Abitaleb (AS University Hospital in Zahedan, a city in South East of Iran, during 2009- 2010. The demographic data and pattern of mental health were collected by standard general health questionnaire (GHQ-28.Data was analyzed using statistical software SPSS (version 17.0; Student t test and Chi-square (?2 were used. Results: In this study, 96 (58.5% patients were male; the mean age of all patients was 18.78 ±2.28. Based on data analysis, 83 patients (50.8% suspected to have psychiatric disorders (58.8% of girls, 44.8% of boys. In addition, frequency of somatic symptoms, depression disorder, anxiety disorder and social dysfunction in all patients were 7.3%, 11.6%, 8.5% and 4.3% respectively. In illiterate patients, 70.4% suspected to have psychiatric disorder. Except for somatic disorder, other mental disorders were more frequent in girls. No significant association was found between mental state and gender, marital and literacy status and occupation. Conclusion : In this study, due to high prevalence of psychological disorders in young patients with Beta-thalassemia major, especially in girls, we suggest implementing further educational psychological programs to decrease the frequency of disorders. Moreover, conducting more quantitative and comprehensive researches is suggested to evaluate specific effective factors in psycho-social health.

Morteza Ashrafi

2012-04-01

31

Renal functions in pediatric patients with beta-thalassemia major: relation to chelation therapy: original prospective study  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background In ?-thalassemia, profound anemia and severe hemosiderosis cause functional and physiological abnormalities in various organ systems. In recent years, there have been few published studies mainly in adult demonstrating renal involvement in ?-thalassemia. This prospective study was aimed to investigate renal involvement in pediatric patients with transfusion dependant beta-thalassemia major (TD-?TM), using both conventional and early markers of glomerula...

2010-01-01

32

The pancreas in {beta}-thalassemia major: MR imaging features and correlation with iron stores and glucose disturbunces  

Energy Technology Data Exchange (ETDEWEB)

The study aims at describing the MR features of pancreas in beta-thalassemia major, investigating the relations between MR findings and glucose disturbances and between hepatic and pancreatic siderosis. Signal intensity ratios of the pancreas and liver to right paraspinous muscle (P/M, L/M) were retrospectively assessed on abdominal MR imaging studies of 31 transfusion-dependent patients with beta-thalassemia major undergoing quantification of hepatic siderosis and 10 healthy controls, using T1- (120/4/90), intermediate in and out of phase - (120/2.7, 4/20), and T2*-(120/15/20) weighted GRE sequences. Using the signal drop of the liver and pancreas on opposed phase images, we recorded serum ferritin and results of oral glucose tolerance test (OGTT). Decreased L/M and P/M on at least the T2* sequence were noticed in 31/31 and 30/31 patients, respectively, but no correlation between P/M and L/M was found. Patients with pathologic OGTT displayed a higher degree of hepatic siderosis (p < 0.04) and signal drop of pancreas on opposed phase imaging (p < 0.025), implying fatty replacement of pancreas. P/M was neither correlated with glucose disturbances nor serum ferritin. Iron deposition in the pancreas cannot be predicted by the degree of hepatic siderosis in beta-thalassemia major. Fatty replacement of the pancreas is common and may be associated with glucose disturbances. (orig.)

Papakonstantinou, Olympia [University Hospital of Heraklion, Medical School of Crete, Department of Radiology, Heraklion, Crete (Greece); Attikon Hospital, 2nd Department of Radiology, Athens (Greece); Ladis, Vasilios; Kostaridou, Stavroula; Berdousi, Helen; Kattamis, Christos [Thalassemia Unit, University of Athens, ' ' Aghia Sophia' ' Children' s Hospital, Athens (Greece); Maris, Thomas; Gourtsoyiannis, Nicholas [University Hospital of Heraklion, Medical School of Crete, Department of Radiology, Heraklion, Crete (Greece)

2007-06-15

33

Attitude toward prenatal diagnosis for beta-thalassemia major and medical abortion in Southern Iran.  

Science.gov (United States)

The aim of this study was to evaluate the degree of acceptability of prenatal diagnosis and voluntary termination of pregnancy in case of a fetus affected with beta-thalassemia major (beta-TM) in patients and their parents in Southern Iran. We interviewed 510 parents who had beta-TM children and 254 patients. A questionnaire was used to record information regarding sex, age, parents' and patients' knowledge about prenatal diagnosis, and their decision regarding abortion of an affected fetus. Of 764 participants, 565 (73.9%) knew a little about prenatal diagnosis and 198 (25.9%) had no knowledge at all, while 711 (93%) were in favor of prenatal diagnosis and 53 (6.9%) were not. Specifically, 663 subjects (86.7%) were in favor of early termination of pregnancy in case of an affected fetus, while (13.2%) were not. Compliance with prenatal diagnosis was high, and the main reason for declining was its cost. No particular correlations were found between the size of the household, the education or the economic level, and the request for early termination of pregnancy of an affected fetus. The decision not to have a medical abortion correlated with religious beliefs only. PMID:20113288

Karimi, Mehran; Johari, Sheyda; Cohan, Nader

2010-01-01

34

Seroprovalence of herpes simplex1, 2 IgG antibodies in patients with beta thalassemia in a major tertiary care hospital located in Yazd, Iran  

Science.gov (United States)

Background Patients with beta thalassemia suffer from increased susceptibility to infections and putridity plays a major role in the patient's morbidity and mortality. The risk of transfusion-transmitted viral infection is well known in these patients. However, there is dearth of information about the seroprevalence of herpes simplex virus (HSV) infection in patients with beta thalassemia in literature. This study analyzes the prevalence of anti-HSV1, 2 IgG antibodies in patients with beta thalassemia in a major tertiary care hospital located in Yazd,Iran. Material and methods In this case control study, we undertook a serological study of HSV1,2 IgG antibodies among 45 patients with beta thalassemia and 45 healthy individuals as control group by ELISA method. A p.value <0.05 was considered statistically significant. Statistical analyses were performed using SPSS.20. Results The prevalence of HSV 1,2 IgG antibodies were estimated 88.8% among patients with beta thalassemia and 77.7% in control group. Regarding p.value=0.64, it showed no significant difference in these two groups. Conclusion Although infectious diseases still represent a major challenge in patients with beta thalassemia, HSV past infection rate was not increased in these patients in our study. More studies are required to clarify this matter.

Atefi, A; Binesh, F; Hashemi, A; Atefi, A; Aminorroaya, MM

2014-01-01

35

The Prevalence of Adrenal, Parathyroid and Cardiac Dysfunction in Patients with Beta Thalassemia Major  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background: Adrenal and parathyroid insufficiency are uncommon in patients with transfusion dependent Beta Thalassemia (?-TM). Further, myocardial echocardiographic abnormalities are recognized but with a variable outcomes Aim: The aim is to determine the prevalence of adrenal and parathyroid insufficiency in patient with transfusion dependent ?-TM.

2013-01-01

36

Side effects of Deferasirox Iron Chelation in Patients with Beta Thalassemia Major or Intermedia  

Directory of Open Access Journals (Sweden)

Full Text Available Objectives: Chelating agents remain the mainstay in reducing the iron burden and extending patient survival in homozygous beta-thalassemia but adverse and toxic effects may increase with the institution and long term use of this essential therapy. This study aimed to estimate the incidence of deferasirox (DFX side effects in patients with thalassemia major or intermedia.Methods: A retrospective study of 72 patients (mean age: 20.3±0.9 yrs; 36 male, 36 female with thalassemia major or intermedia treated at Sultan Qaboos University Hospital, Oman, was performed to assess the incidence of side effects related to deferasirox over a mean of 16.7 month follow-up period.Results: Six patients experienced rashes and 6 had gastro-intestinal upset. DFX was discontinued in 18 patients for the following reasons: persistent progressive rise(s in serum creatinine (7 patients; 40% mean serum creatinine rise from baseline, feeling unwell (2, severe diarrhea (1, pregnancy (1, death unrelated to chelator (2 and rise in serum transaminases (2. Three patients were reverted to desferoxamine and deferiprone combination therapy as DFX was no longer biochemically effective after 18 months of therapy. There was no correlation between baseline serum ferritin and serum creatinine or a rise in serum creatinine. Cardiac MRI T2* did not change with DFX therapy. However, there was an improvement in liver MRI T2* (p=0.013.Conclusion: Renal side effects related to deferasirox appear to be higher than those reported in published clinical trials. Further larger studies are required to confirm these findings.

Murtadha Al-Khabori

2013-03-01

37

A Study of Leptin Serum Concentrations in Patients with Major Beta-Thalassemia  

Directory of Open Access Journals (Sweden)

Full Text Available AbstractBackground The aim of this study was to evaluate leptin serum levels in patients with major beta thalassemia which was also associated with their ferritin serum levels. Materials and MethodsThis case-control study was performed on 90 children -6 months to 16 years old, in Zabol, Amir- al- Momenin Hospital. Patients were divided in two groups and were matched in age and sex. All Children were examined and those eligible children who had not known heart disease, iron deficiency anemia, kidney disease, diabetes, fever and systemic diseases were enrolled after taking the informed consent of their parents. After collecting the samples, leptin and ferritin levels of the serum were measured in two groups by ELISA method. Then, the data was analyzed by the related statistical tests and SPSS 20 software.ResultsThe mean of the serum levels of leptin and ferritin showed a significant difference in the case and control groups (P-value<0.05. An inverse statistical correlation was found for the serum levels of leptin and ferritin among the studied groups (P-value<0.05. Levels of leptin in the case group showed a significant gender difference (P-value<0.05, while based on BMI and age, no significant difference was observed for the serum levels of leptin in the case group.ConclusionBased on the results of this study, major thalassemia reduces serum levels of leptin regardless of age and body mass. The study also found an inverse statistical correlation between serum levels of leptin and ferritin among the studied people.

Shahramian I MD

2013-06-01

38

Hydroxyurea in the treatment of major beta-thalassemia and importance of genetic screening.  

Science.gov (United States)

Efforts have been undertaken to find an alternative approach to packed red cell transfusion (PRCT) in major beta-thalassemia. Augmentation of fetal hemoglobin (HbF) by hydroxyurea (HU) has been reported to be less effective in this condition as compared to sickle cell anemia due to molecular heterogeneity of the former disease. HU efficacy and its relation to Xmn1 polymorphism and IVSII-1 mutation was evaluated in major beta-thalassemics. Forty-five patients, M/F ratio 0.8, aged 6-33 years, received oral HU, 20 mg/kg per day, 4 days per week and daily1 mg folic acid. Thirty-six patients were PRCT dependent (group A) and nine independent (group B). The aim was to stabilize or increase pre-PRCT Hb over 10.0+/-0.5 g/dl and to reduce the need or cease the PRCT in group A and to increase Hb level and curb the ineffective erythropoesis, e.g., splenomegaly, facial bone deformity, in group B. HU was administered for at least 6 months (mean: 9 months) and discontinued in case of response failure. Screening for Xmn1 polymorphism and IVSII-1 mutation was carried out in most patients. In group A, 25 patients have become PRCT independent for a period of 2.5-7.3 years (mean: 4 years). The mean Hb, pre-HU 10.0 and post-HU 10.7 g/dl (range: 8.8-13.7 g/dl), mean serum ferritin pre- and post-HU was1877 and 525 ng/ml. The PRCT requirement was reduced in one patient, and ten patients did not respond. In group B HU has been given over 3.3 years (range: 2.8-4.8 years), Hb increased from 9.3 to 10.4/dl, and there was no tangible progression of ineffective erythropoesis. Responders in both groups expressed more comfort with this regimen. Xmn1 and IVSII-1 (homo- and/or heterozygosis) are relevant markers in most responding patients. Molecular determination of genetic markers in early childhood will help to identify candidates for pharmacological HbF switching by HU. PMID:14722738

Alebouyeh, M; Moussavi, F; Haddad-Deylami, H; Vossough, P

2004-07-01

39

Growth hormone (GH) deficiency in patients with beta-thalassemia major and the efficacy of recombinant GH treatment.  

Science.gov (United States)

Patients with beta-thalassemia major still suffer growth retardation. After excluding patients with cortisol deficiency, hypothyroidism, hypogonadism, delayed puberty, malnutrition, severe congestive heart failure, and severely impaired liver function, 29 patients were enrolled in this study. Fifteen (52%) patients exhibited growth retardation and underwent two growth hormone (GH) provocation tests. Eight (53%) of the 15 patients had GH deficiency and were subsequently treated with subcutaneous recombinant human GH (Genotropin, Pharmacia Corporation, Sweden). Growth velocity increased from the pretreatment rate of 3.1+/-0.4 cm/year to 7.1+/-1.6 cm/yr (p<0.001) after 1 year and to 6.8+/-1.3 cm/year (p<0.001) after 2 years. Patients with growth retardation had lower insulin like growth factor-1 (p=0.001) and insulin like growth factor binding protein-3 (p=0.003) levels than those without growth retardation. In patients with beta-thalassemia major, growth retardation is a common complication and GH deficiency plays an important role. Thalassemic patients with GH deficiency can safely increase their growth velocity with recombinant human GH for 2 years; however, the effect on final height still needs to be determined. PMID:12898188

Wu, K H; Tsai, F J; Peng, C T

2003-10-01

40

The Prevalence of Adrenal, Parathyroid and Cardiac Dysfunction in Patients with Beta Thalassemia Major  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Adrenal and parathyroid insufficiency are uncommon in patients with transfusion dependent Beta Thalassemia (?-TM. Further, myocardial echocardiographic abnormalities are recognized but with a variable outcomes Aim: The aim is to determine the prevalence of adrenal and parathyroid insufficiency in patient with transfusion dependent ?-TM. And to assess left ventricle systolic and diastolic function using Pulsed Doppler (PD and Tissue Doppler (DT echocardiogram. Methods:The study was conducted on patients with ?-TM (n = 99, age 15.92 ± 8.92 years and compared with an age-matched controls (n = 98 age 15.79 ± 8.94 years. In all participants echocardiographic indices of M mode and PD and TD were performed. Blood samples were withdrawn for measuring the serum cortisol, parathyroid and Ferritin. Correlation between the level of cortisol and ferritin level was evaluated. Results: Patients with ?-TM compared with controls, had significantly thicker LV septal wall index of 0.65 ± 0.26 vs 0.44 ± 0.2190, p 0.001 and LV posterior wall of 0.65 ± 0.235 vs 0.43 ± 0.214, p   ± 5.5 vs 5.0  ± 5.6, p = 0.23. Furthermore patients with ?-TM had higher E/A ratio (1.54 ± 0.18 vs 1.23 ± 0.17, p 0.01 and shorter deceleration time (DT (170.53 ± 13.3 vs 210.50 ± 19.20 m sec, p 0.01. The ratio of transmitral E wave velocity to the tissue Doppler E wave at the basal septal mitral annulus (E/Em was significantly higher in ?-TM group (19.68 ± 2.81 vs 13.86 ± 1.41, p 0.05. The tissue Doppler systolic wave (Sm velocity and the early diastolic wave (Em were significantly lower in ?-TM group compared with controls with Sm, of 4.82 ± 1.2 vs 6.22 ± 2.1 cm/sec, p 0.05 and (Em of 3.51 ± 2.7 vs 4.12 ± 2.5 cm/sec p 0.05, respectively. The tricuspid valve velocity was significantly higher in ?-TM patients compared with controls (2.85 ± 0.56 vs 1.743 ± 0.47 m/sec, respectively, p 0.01. The prevalence of adrenal insufficiency in patients with ?-TM was 16%, hypoparathyroidism of 4.5% weak negative correlation between serum level of cortisol and the serum Ferritin. Conclusion: Patients with ?-thalassemia major had a high prevalence of subclinical adrenal insufficiency of 16%, hypoparathyroidism of 4.5% with weak negative correlation between the low level of cortisol ?160 nmol/L and high serum ferritin. Echocardiographic Pulsed Doppler showed a restrictive LV diastolic pattern suggestive of advanced diastolic dysfunction but preserved left ventricle systolic function.

Najat E. Mahdi

2013-07-01

 
 
 
 
41

Associates of poor physical and mental health-related quality of life in beta thalassemia-major/intermedia  

Directory of Open Access Journals (Sweden)

Full Text Available

  • BACKGROUND: Using two logistic regression models, we determined the associates of poor physical and mental health related quality of life (HRQoL among beta thalassemia patients.
  • METHODS: In this cross-sectional study which was conducted during 2006 and 2007 in outpatient adult thalassemia clinic, Blood Transfusion Organization, Tehran, Iran, Short Form 36 (SF-36 was used for measuring HRQoL in 179 patients with beta thalassemia (major/intermedia. We determined scores higher than third quartiles of obtained PCS and MCS scores as the cutoff points of good HRQoL. Poor HRQoL was defined scores lower than first quartiles of obtained PCS and MCS scores. Two distinct logistic regression models were used to derive associated variables including demographic, clinical, and psychological factors.
  • RESULTS: The regression models suggested that poor physical HRQoL was positively associated with somatic comorbidities (OR = 1.472, CI = 1.021-2.197, p = 0.048 and depression score (OR = 8.568, CI = 2.325-31.573, p = 0.001. The variables that were associated with poor mental HRQoL were anxiety score (OR = 9.409, CI = 1.022-89.194, p = 0.049 and depression score (OR = 20.813, CI = 4.320-100.266, p < 0.001.
  • CONCLUSIONS: Depression is associated with both poor physical and mental HRQoL among patients with major/intermedia beta thalassemia, however somatic comorbidities and anxiety are associated with poor physical and mental HRQoL, respectively.
  • KEYWORDS: Thalassemia, Health Related Quality of Life, Anxiety, Depression, Somatic Comorbidities.

Azita AzarKeyvan

2009-11-01

42

Prevalence and Intensity of Depression in Mothers of Children with Beta-Thalassemia Major In Talghani Hospital of Gorgan, Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Thalassemia is a chronic disease that it leads to psychological and social problems for parents. Mothers are at markedly increased risk of suffering from psychological distress and depression because they usually take on a considerable part of extra care that their children need.This study was designed to determine prevalence and intensity of depression in mothers with a thalassemic child. Material and Methods: In this cross – sectional study, 65 mothers of children with thalassemia major (case group and 65 mothers of children without thalassemia major (control group were assessed using the Beck Depression Inventory (BDI. Data were analyzed by using SPSS (v 16.0 for windows. Results: Prevalence of depression was significantly higher in case group than that in control group (84.6%vs. 56.9%, p <0.05. Moderate depression had a highest prevalence in the both groups (33.4% in case group and 30.8% in control group. Prevalence of severe depression in case group was markedly higher than that in control group (29.2% vs. 3.1% p<0.05. There was a significant difference between intensity of depression in mothers of case group that had another child with beta-thalassemia major (p<0.05. Conclusion: Mothers of children with thalassemia major are vulnerable to depression. They need psychosocial support to promote their health.

Nargesbeygom Mirbehbahani

2014-01-01

43

Phase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in pediatric patients with beta-thalassemia major  

Digital Repository Infrastructure Vision for European Research (DRIVER)

BACKGROUND AND OBJECTIVES: Deferasirox (ICL670) is a novel once-daily oral iron chelator developed for the treatment of chronic iron overload from blood transfusions. This study evaluated the safety and tolerability of deferasirox in pediatric patients with transfusion-dependent beta-thalassemia major. Efficacy and pharmacokinetic assessments were secondary objectives. DESIGN AND METHODS: Forty patients equally stratified into two age groups--children (2 to <12 years) and adolescents (12-17 y...

Piga, Antonio Giulio

2006-01-01

44

Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients: A Review of the Literature  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Beta thalassemia major is an inherited disease resulting from reduction or total lack of beta globin chains. Patients with this disease need repeated blood transfusion for survival. This may cause oxidative stress and tissue injury due to iron overload, altered antioxidant enzymes, and other essential trace element levels. The aim of this review is to scrutinize the relationship between oxidative stress and serum trace elements, degree of damage caused by oxidative stress, and the role of ant...

Shazia, Q.; Mohammad, Z. H.; Taibur Rahman; Hossain Uddin Shekhar

2012-01-01

45

French multicenter 22-year experience in stem cell transplantation for beta-thalassemia major: lessons and future directions.  

Science.gov (United States)

Although hematopoietic stem cell transplantation (HSCT) offers curative potential for beta-thalassemia major (beta-TM), it is associated with a variable but significant incidence of graft rejection. We studied the French national experience for improvement over time and the potential benefit of antithymocyte globulin (ATG). Between December 1985 and December 2007, 108 patients with beta-TM underwent HSCT in 21 different French transplantation centers. The majority of patients received a matched sibling transplant (n = 96) and a busulfan- and cyclophosphamide-based conditioning regimen (n = 95), also with ATG in 57 cases. Ninety-five of the 108 patients survived, with a median follow-up of 12 years. Probabilities of 15-year survival and thalassemia-free survival after first HSCT were 86.8% and 69.4%, respectively. Graft failure occurred in 24 patients, 11 of whom underwent a second HSCT. The use of ATG was associated with a decrease in rejection rate from 35% to 10%. Thalassemia-free survival improved significantly with time, reaching 83% in the 54 patients undergoing HSCT after 1994 (median time of HSCT). In view of the increased risk of graft rejection after matched sibling HSCT, current French national guidelines recommend, for all children at risk for beta-TM, the systematic addition of ATG to the myeloablative conditioning regimen and special attention to optimize transfusion and chelation therapy in the pretransplantation period. PMID:22892550

Galambrun, Claire; Pondarré, Corinne; Bertrand, Yves; Loundou, Anderson; Bordigoni, Pierre; Frange, Pierre; Lutz, Patrick; Mialou, Valérie; Rubie, Hervé; Socié, Gérard; Schneider, Pascale; Bernaudin, Françoise; Paillard, Catherine; Michel, Gérard; Badens, Catherine; Thuret, Isabelle

2013-01-01

46

Beta-thalassemia  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world and 1 in 10,000 people in the European Union. Three main forms have been described: thalassemia major, thalassemia intermedia and thalassemia minor. Individuals with thalassemia major usually present within the first two years of life with severe anemia, requiring regular red blood cell (RBC transfusions. Findings in untreated or poorly transfused individuals with thalassemia major, as seen in some developing countries, are growth retardation, pallor, jaundice, poor musculature, hepatosplenomegaly, leg ulcers, development of masses from extramedullary hematopoiesis, and skeletal changes that result from expansion of the bone marrow. Regular transfusion therapy leads to iron overload-related complications including endocrine complication (growth retardation, failure of sexual maturation, diabetes mellitus, and insufficiency of the parathyroid, thyroid, pituitary, and less commonly, adrenal glands, dilated myocardiopathy, liver fibrosis and cirrhosis. Patients with thalassemia intermedia present later in life with moderate anemia and do not require regular transfusions. Main clinical features in these patients are hypertrophy of erythroid marrow with medullary and extramedullary hematopoiesis and its complications (osteoporosis, masses of erythropoietic tissue that primarily affect the spleen, liver, lymph nodes, chest and spine, and bone deformities and typical facial changes, gallstones, painful leg ulcers and increased predisposition to thrombosis. Thalassemia minor is clinically asymptomatic but some subjects may have moderate anemia. Beta-thalassemias are caused by point mutations or, more rarely, deletions in the beta globin gene on chromosome 11, leading to reduced (beta+ or absent (beta0 synthesis of the beta chains of hemoglobin (Hb. Transmission is autosomal recessive; however, dominant mutations have also been reported. Diagnosis of thalassemia is based on hematologic and molecular genetic testing. Differential diagnosis is usually straightforward but may include genetic sideroblastic anemias, congenital dyserythropoietic anemias, and other conditions with high levels of HbF (such as juvenile myelomonocytic leukemia and aplastic anemia. Genetic counseling is recommended and prenatal diagnosis may be offered. Treatment of thalassemia major includes regular RBC transfusions, iron chelation and management of secondary complications of iron overload. In some circumstances, spleen removal may be required. Bone marrow transplantation remains the only definitive cure currently available. Individuals with thalassemia intermedia may require splenectomy, folic acid supplementation, treatment of extramedullary erythropoietic masses and leg ulcers, prevention and therapy of thromboembolic events. Prognosis for individuals with beta-thalassemia has improved substantially in the last 20 years following recent medical advances in transfusion, iron chelation and bone marrow transplantation therapy. However, cardiac disease remains the main cause of death in patients with iron overload.

Origa Raffaella

2010-05-01

47

Associates of poor physical and mental health-related quality of life in beta thalassemia-major/intermedia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

  • BACKGROUND: Using two logistic regression models, we determined the associates of poor physical and mental health related quality of life (HRQoL) among beta thalassemia patients.
  • METHODS

    Azita AzarKeyvan; Bashir HajiBeigi; Maryam Moghani Lankarani; Mahshid Namdari; Shervin Assaric

    2009-01-01

48

Correlation of Echocardiography and MRI T2* in Beta- Thalassemia Major  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Introduction:Transfusional therapy can lead to iron deposition and damage to the heart, liver and endocrine organs in thalassemia major patients. Cardiomyopathy is one of the major complications of ?-thalassemic patients, resulting from iron overload. It is one of the major causes of morbidity and mortality in these patients. It has been shown that there is no correlation between serum ferritin and liver and heart iron deposition. Endocardial biopsy for iron deposition is the most accura...

Maryam Barzan; Mehrnoosh Kowsarian; Rozita Jalalian; Shahram akhlaghpoor; Mehdi Taremi

2009-01-01

49

Correlation of Echocardiography and MRI T2* in Beta- Thalassemia Major  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction:Transfusional therapy can lead to iron deposition and damage to the heart, liver and endocrine organs in thalassemia major patients. Cardiomyopathy is one of the major complications of ?-thalassemic patients, resulting from iron overload. It is one of the major causes of morbidity and mortality in these patients. It has been shown that there is no correlation between serum ferritin and liver and heart iron deposition. Endocardial biopsy for iron deposition is the most accurate test in this regard, which is invasive. Iron shortens MRI parameters T1, T2 and T2* in the involved organs, which creates a potential mechanism for iron quantification. MRI T2* has especially been shown to have an inverse correlation with iron overload in the myocardium. Values less than 20 ms show significant iron deposition. Recently echocardiographic measures have been introduced to estimate the iron status of the myocardium. As diastolic dysfunction may precede systolic dysfunction, echocardiographic indices of diastolic function may be compared with myocardial MRI T2*."nMaterials and Methods: In this study, 35 major thalassemic patients from thalassemia research center at Bou Ali Sina hospital, Sari were enrolled. They have been under transfusion for a mean time of 15 years. Informed consent was filled and echocardiography and MRI T2* has been performed for all patients. The result for each test and the correlation of both procedures are shown in correlation with cardiac performance.

Maryam Barzan

2009-01-01

50

Comparative Evaluation of Renal Findings in Beta-Thalassemia Major and Intermedia  

Directory of Open Access Journals (Sweden)

Full Text Available Thalassemia is a systematic disease in which the renal involvement has not yet been scrupulously studied. In a cross-sectional study, the renal findings of 50 cases of thalassemia intermedia (group 1 were compared to 58 patients with thalassemia major (group 2. Blood urea nitrogen, serum creatinine, uric acid, calcium, phosphorus, urinalysis, and ultrasonographical findings were evaluated. Mean age was 18 ± 3.0 in group 1 and 17 ± 3.5 years in group 2. The mean of serum ferritin levels was 871 ± 81.8 ng/ml in group 1 vs. 3503 ± 201 ng/ml in thalassemia major (p < 0.05. Ninety-two percent of the patients in group 1 were on hydroxyurea at the time of evaluation. Serum uric acid was significantly higher in group 1 than group 2 patients (5.74 ± 2.95 vs. 4.12 ± 0.9 mg/dl, p < 0.05. Microscopic hematuria (red blood cell in high power field of urine microscopy > 5 was observed among 19 children (17.6%; 17 of them were in group 1. In contrast, children with thalassemia major had significantly higher serum creatinine (0.89 ± 0.18 vs. 0.59 ± 0.37 mg/dl, p < 0.05 and blood urea nitrogen values (12.14 ± 5.58 vs. 13.85 ± 3.54 mg/dl, p < 0.05. We conclude that significant renal involvement is not a frequent complication in children and young adults suffering from thalassemia. Hyperuricemia and microscopic hematuria are more common in thalassemia intermedia than thalassemia major. Microscopic hematuria in thalassemia intermedia might be related to either hypercalciuria or hyperuricosuria.

Ali Derakhshan

2008-01-01

51

Renal functions in pediatric patients with beta-thalassemia major: relation to chelation therapy: original prospective study  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background In ?-thalassemia, profound anemia and severe hemosiderosis cause functional and physiological abnormalities in various organ systems. In recent years, there have been few published studies mainly in adult demonstrating renal involvement in ?-thalassemia. This prospective study was aimed to investigate renal involvement in pediatric patients with transfusion dependant beta-thalassemia major (TD-?TM, using both conventional and early markers of glomerular and tubular dysfunctions, and to correlate findings to oxidative stress and iron chelation therapy. Methods Sixty-nine TD-?TM patients (aged 1-16 years and 15 healthy controls (aged 3-14 years were enrolled in this study. Based on receiving chelation therapy (deferoxamine, DFO, patients were divided into two groups: group [I] with chelation (n = 34 and group [II] without chelation (n = 35. Levels of creatinine (Cr, calcium (Ca, inorganic phosphorus (PO4, uric acid (UA and albumin were measured by spectrophotometer. Serum (S levels of cystatin-C (SCysC and total antioxidant capacity (STAC and urinary (U levels of ?2-microglobulin (U?2MG were measured by immunosorbent assay (ELISA. Urinary N-acetyl-beta-D-glucosaminidase (UNAG activity and malondialdehyde (UMDA were measured by chemical methods. Estimated glomerular filtration rate (eGFR was determined from serum creatinine. Results In patient with and without chelation, glomerular [elevated SCysC, SCr, Ualbumin/Cr and diminished eGFR]; and tubular dysfunctions [elevated SUA, SPO4, UNAG/Cr, U?2MG/Cr] and oxidative stress marker disturbances [diminished STAC and elevated UMDA/Cr] were reported than controls. In patients with chelation, SCysC was significantly higher while, STAC was significantly lower than those without chelation. In all patients, SCysC showed significant positive correlation with SCr and negative correlation with eGFR; STAC showed significant positive correlation with eGFR and negative correlation with SCysC, SCr, UNAG/Cr; UMDA/Cr showed significant positive correlation with Ualbumin/Cr, U?2MG/Cr, UNAG/Cr. Conclusions Our data confirm high frequency of glomerular and tubular dysfunctions in TD-?TM pediatric patients which could be attributed to oxidative stress and DFO therapy.

ElMelegy Nagla T

2010-05-01

52

Cross-talk between available guidelines for the management of patients with beta-thalassemia major.  

Science.gov (United States)

Efforts to optimize the management of patients with ?-thalassemia major (TM) continue to expand. Evidence from biomedical research evaluating safe and careful processing measures of blood products, the efficacy and safety of oral iron chelators, and noninvasive techniques for the assessment of iron overload are translated into better patient outcomes. The construction of TM management guidelines facilitated the incorporation of such evidence into practice. However, as several aspects of the management of TM remain controversial or governed by resource availability, a concern regarding potential variations in recommendations made by the different guidelines becomes rational, especially for physicians treating TM patients outside countries where the guidelines were constructed. In this work, we overview currently available guidelines for the management of TM and explore apparent similarities and differences between them. The evaluated guidelines included the Thalassaemia International Federation, US, Canadian, UK, Italian and Australian guidelines. We noted a general consensus for most aspects of management, although some guidelines provided more comprehensive and contemporary recommendations than others. We did not identify differences warranting concern, although minor differences in iron overload assessment strategy and more notable variations in the recommendations for iron chelation therapy were observed. PMID:23485589

Musallam, Khaled M; Angastiniotis, Michael; Eleftheriou, Androulla; Porter, John B

2013-01-01

53

The Correlation between Troponin and Ferritin Serum Levels in the Patients with Major Beta-Thalassemia  

Science.gov (United States)

Background Thalassemia is a hereditary hemoglobinopathy whose most common complication is cardiac involvement which ends up in these patients’ death. Since troponin is a sensitive and specific marker for the detection of microinfarct, we studied the relationship between troponin and ferritin serum levels for early diagnosis of cardiac involvement in these patients. Materials and Methods This case-control study was performed on 80 patients, including 40 patients with major thalassemia and normal echocardiography and 40 healthy volunteers ranging from 6 months to 16 years old. All the children were examined and the eligible children who were not infected with known heart disease, iron deficiency anemia, kidney disease, diabetes, fever, and systemic diseases were enrolled into the study after obtaining written informed consents from their parents. At 8:00 A.M. before breakfast, 5cc blood was drawn from these children. After collecting the samples, ferritin and troponin serum levels were evaluated using ELISA and electro- kymonolonsense methods, respectively. The gathered data were analyzed through the SPSS statistical software (v. 20) and T-test. Besides, P value<0.05 was considered as statistically significant. Results The study results revealed a significant difference between the two groups regarding the mean of the serum levels of troponin (P=0.045) and ferritin (P=0.001). In this study, no significant correlation was observed between serum troponin and ferritin levels and age and BMI in the two groups. Also, no significant relationship was found between serum troponin level and sex (P=0.264). Conclusions In microinfarct, troponin increases independent of ferritin; therefore, it can be used for early detection of cardiac involvement in thalassemia patients to determine the sub-clinical effects.

Shahramian, Iraj; Razzaghian, Motahhare; Ramazani, Abbas Ali; Ahmadi, Ghasem Ali; Noori, Noor Mohammad; Rezaee, Ali Reza

2013-01-01

54

Co-existence of Phenylketonuria (PKU and beta-Thalassemia Major in a 16 Years Old Girl: A Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available While thalassemia major (TM used to be a prevalent genetic disease in the past, however, (PKU is quite rare in spite of consanquiness marriage rate of about 40% in the region. Preventive efforts for TM started >20 years ago but neonatal screening for PKU started since 2007. This is the first report of co-existence of thalassemia and PKU in Middle East and in consideration of the prevalence of each genes, this chance association is a very unusual event. We report a case of having PKU and TM

Hossein Karami

2012-07-01

55

Co-existence of Phenylketonuria (PKU) and beta-Thalassemia Major in a 16 Years Old Girl: A Case Report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

While thalassemia major (TM) used to be a prevalent genetic disease in the past, however, (PKU) is quite rare in spite of consanquiness marriage rate of about 40% in the region. Preventive efforts for TM started >20 years ago but neonatal screening for PKU started since 2007. This is the first report of co-existence of thalassemia and PKU in Middle East and in consideration of the prevalence of each genes, this chance association is a very unusual event. We report a case of having PKU and TM

2012-01-01

56

Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Thalassemia is a hereditary anemia resulting from defect in hemoglobin production. Beta thalassemia is due to impaired production of beta globin chains, leading to a relative excess of alpha globin chains. The term beta thalassemia minor is used to describe heterozygotes, who carry one normal beta globin allele and one beta thalassemic allele. The vast majority of these patients are asymptomatic. However, a variety of renal tubular abnormalities including hypercalciuria, hypo-magnesemia with ...

Prabahar Murugesan; Jain Manish; Chandrasekaran Venkatraman; Indhumathi Elayaperumal; Soundararajan Periasamy

2008-01-01

57

Vitamin E in beta-thalassemia.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In homozygous beta-thalassemia low serum level of alpha-tocopherol have been found. The administration of high doses of the vitamin increased the serum level, decreased lipid peroxidation and, in some case, prolonged red blood cell survival; no significant change in transfusion requirement was obtained. Only few data are available about the vitamin E in heterozygous beta-thalassemia. We have studied 131 patients aged 1 to 72 years with thalassemic trait and 218 age-matched controls. Serum lev...

Ghigo, Dario Antonio

1982-01-01

58

The spectrum of beta-thalassemia mutations in Taiwan: identification of a novel frameshift mutation.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Seventy-four beta-thalassemia genes from 37 unrelated beta-thalassemia-major patients were systematically characterized by using PCR, dot-blot hybridization, and direct sequencing of amplified genomic DNA. We found that six mutations--namely, II-654, 41/42, -28, 17 beta, -29, and 27/28--were prevalent, accounting, respectively, for 45.9%, 28.4%, 10.8%, 10.8%, 1.4%, and 2.7% of studied patients. The 27/28 mutation has at codon 27-28 a cytosine insertion which has never been reported before. Th...

Lin, L. I.; Lin, K. S.; Lin, K. H.; Chang, H. C.

1991-01-01

59

Intracranial Extramedullary Hematopoiesis in Beta-Thalassemia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Extramedullary hematopoiesis (EMH) represents tumor-like proliferation of hemopoietic tissue which complicates chronic hemoglobinopathy. Intracranial EMH is an extremely rare occurrence. Magnetic resonance imaging (MRI) offers a precise diagnosis. It is essential to distinguish EMH from other extradural central nervous system tumors, because treatment and prognosis are totally different. Herein, we report the imaging findings of beta-thalassemia in a 13-year-old boy complaining of weakness of...

Karki, Bivek; Xu, Yi-kai; Tamrakar, Karuna; Wu, Yuan-kui

2012-01-01

60

Intracranial Extramedullary Hematopoiesis in Beta-Thalassemia  

Energy Technology Data Exchange (ETDEWEB)

Extramedullary hematopoiesis (EMH) represents tumor-like proliferation of hemopoietic tissue which complicates chronic hemoglobinopathy. Intracranial EMH is an extremely rare occurrence. Magnetic resonance imaging (MRI) offers a precise diagnosis. It is essential to distinguish EMH from other extradural central nervous system tumors, because treatment and prognosis are totally different. Herein, we report the imaging findings of beta-thalassemia in a 13-year-old boy complaining of weakness of left side of the body and gait disturbance; CT and MRI revealed an extradural mass in the right temporoparietal region.

Karki, Bivek; Xu, Yi Kai; Wu, Yuan Kui [Nan fang Hospital, Southern Medical University, Guangzhou (China); Tamrakar, Karuna [Zhujiang Hospital, Southern Medical University, Guangzhou (China)

2012-03-15

 
 
 
 
61

Intracranial Extramedullary Hematopoiesis in Beta-Thalassemia  

International Nuclear Information System (INIS)

Extramedullary hematopoiesis (EMH) represents tumor-like proliferation of hemopoietic tissue which complicates chronic hemoglobinopathy. Intracranial EMH is an extremely rare occurrence. Magnetic resonance imaging (MRI) offers a precise diagnosis. It is essential to distinguish EMH from other extradural central nervous system tumors, because treatment and prognosis are totally different. Herein, we report the imaging findings of beta-thalassemia in a 13-year-old boy complaining of weakness of left side of the body and gait disturbance; CT and MRI revealed an extradural mass in the right temporoparietal region.

2012-03-01

62

Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor  

Directory of Open Access Journals (Sweden)

Full Text Available Thalassemia is a hereditary anemia resulting from defect in hemoglobin production. Beta thalassemia is due to impaired production of beta globin chains, leading to a relative excess of alpha globin chains. The term beta thalassemia minor is used to describe heterozygotes, who carry one normal beta globin allele and one beta thalassemic allele. The vast majority of these patients are asymptomatic. However, a variety of renal tubular abnormalities including hypercalciuria, hypo-magnesemia with renal magnesium wasting, decreased tubular absorption of phosphorus, hypo-uricemia with renal uric acid wasting, renal glycosuria and tubular proteinuria have been described even in patients with beta thalassemia minor. We here in report a 24-year old female patient who was found to have thalassemia minor and nephrocalcinosis with evidence of renal tubular dysfunction. Investigations revealed normal renal function, hypercalciuria, reduced tubular reabsorption of phos-phorus, hypomagnesemia and renal magnesium wasting. Screening for aminoaciduria was found to be negative. An acid loading test revealed normal urinary acidification. Ultrasonogram of the abdomen revealed nephrocalcinosis and splenomegaly. Detailed work up for anemia showed normal white cell and platelet count while peripheral smear showed microcytic hypochromic anemia with few target cells. Hemoglobin electrophoresis revealed hemoglobin A of 92%, hemoglobin A2 of 6.2% and hemo-globin F of 1.8% consistent with beta thalassemia minor. Her parental screening was normal. A diag-nosis of beta thalassemia minor with renal tubular dysfunction was made and the patient was started on thiazide diuretics to reduce hypercalciuria and advised regular follow-up.

Prabahar Murugesan

2008-01-01

63

EXERCISE STRESS ECHOCARDIOGRAPHY WITH TISSUE DOPPLER IMAGING (TDI) DETECTS EARLY SYSTOLIC DYSFUNCTION IN BETA-THALASSEMIA MAJOR PATIENTS WITHOUT CARDIAC IRON OVERLOAD  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Iron Overload Cardiomyopathy (IOC) is still the main cause of death in thalassemia major (TM) patients. Unfortunately, Conventional Echocardiography fails to predict early cardiac dysfunction. As Tissue Doppler Imaging (TDI) may demonstrate regional myocardial dysfunction, we wondered if exercise may reveal abnormalities at TDI which are not evident at rest. To try to evaluate left and right myocardial performances at rest and after maximal exercise by both conventional and TDI param...

2012-01-01

64

EXERCISE STRESS ECHOCARDIOGRAPHY WITH TISSUE DOPPLER IMAGING (TDI DETECTS EARLY SYSTOLIC DYSFUNCTION IN BETA-THALASSEMIA MAJOR PATIENTS WITHOUT CARDIAC IRON OVERLOAD  

Directory of Open Access Journals (Sweden)

Full Text Available

Iron Overload Cardiomyopathy (IOC is still the main cause of death in thalassemia major (TM patients. Unfortunately, Conventional Echocardiography fails to predict early cardiac dysfunction. As Tissue Doppler Imaging (TDI may demonstrate regional myocardial dysfunction, we wondered if exercise may reveal abnormalities at TDI which are not evident at rest. To try to evaluate left and right myocardial performances at rest and after maximal exercise by both conventional and TDI parameters, 46 beta-TM adult patients and 39 control subjects were enrolled. All patients had a liver iron quantification by Superconducting Quantum Interference Device (SQUID and also a cardiac iron assessment by MRI (T2*: 38 TM patients had no evidence of cardiac iron overload. Whereas TM patients did not shown diastolic dysfunction and all of them presented a good global response to exercise, TDI detected a reduced increase of the S’ waves of left ventricle basal segment during exercise. This finding seems to have some weak but interesting relations with iron overload markers. In conclusion, in our study, exercise stress TDI-echocardiography was able to demonstrate subtle systolic abnormalities that were missed by Conventional Echocardiography. Further studies are required to determine the meaning and the clinical impact of these results.

Umberto Barbero

2012-01-01

65

Investigation of RBC Indices and HbA2 Levels in Parents of Beta-Thalassemia Patients: Impacts on Premarital Genetic Counseling  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective: This study was designed to investigate RBC indices and HbA2 levels in parents of major beta-thalassemia patients to detect possible silent beta- thalassemia carriers and examine its potential impact on the premarital genetic counseling.Materials and Methods: This cross sectional study was performed at Children Medical Center from 2004 to 2006. After genetic counseling and getting informed consent, peripheral blood sampling was carried out on 185 carrier parents of regularly blood t...

Mina Izadyar; Jila Dastan; Tayebeh Sabokbar; Solmaz Shoraka; Azadeh Shojaei; Habib Nasiri; Saeed Reza Ghaffari

2007-01-01

66

The levels of nitric oxide in beta-thalassemia minor  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVE: The aim of this study was to investigate the relationship between NO (nitric oxide and beta-thalassemia minor. METHODS: A total of 60 patients with beta-thalassemia minor (30 M, 30 F were included in the study. The control group consisted of 60 healthy subjects (30 M, 30 F. Plasma nitrite/nitrate levels were measured using the Griess reaction method and analyzed by spectrophotometry at 545 nm.RESULTS: Plasma direct nitrite, total nitrite and nitrate levels were 7.561±6.19, 42.548±7.37 and 34.84±6.24 in beta-thalassemia minor patients versus 36.9±19.8, 85.9±35.3 and 48.61±17.35 Ìmol/dl in controls, respectively. Plasma direct nitrite, total nitrite and nitrate levels were significantly lower in beta-thalassemia minor patients compared with the control group (p<0.001. CONCLUSION: These findings confirm that plasma NO levels in beta-thalassemia minor patients are decreased at the time of diagnosis. This may be helpful in assessing the prognosis and follow-up evaluation of patients with beta-thalassemia minor.

Yalç?n Ba?aran

2008-12-01

67

Quality of life among Iranian patients with beta-thalassemia major using the SF-36 questionnaire / Qualidade de vida em pacientes iranianos com beta-talassemia maior usando o questionario SF-36  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO E OBJETIVO Pacientes com beta-talassemia maior (?-TM) vivenciam problemas físicos, psicológicos e sociais que levam à diminuição da qualidade de vida (QV). O objetivo foi determinar a QV relacionada à saúde e seus determinantes em pacientes com ?-TM, utilizando questionário SF-36 [...] (Short Form-36). TIPO DE ESTUDO E LOCAL Estudo transversal no Centro de Hematologia e Pesquisa em Universidade de Ciências Médicas de Shiraz, no sul do Irã. MÉTODOS Foram selecionados aleatoriamente 101 pacientes com ?-TM. Após registro demográfico e características da doença, eles foram convidados a preencher o questionário SF-36. A correlação entre fatores clínicos e demográficos com escore de QV foi avaliada. RESULTADOS Havia 44 homens e 57 mulheres, com idade média de 19,52 ± 4,3 (variação 12-38) anos. Em duas escalas, dor (P = 0,041) e aspectos emocionais (P = 0,009), as mulheres apresentaram escores significativamente menores aos dos homens. Menor renda, baixa adesão à terapia quelante de ferro e presença de comorbidades foram correlacionadas com escores SF-36 significativamente menores. Esses fatores foram também considerados determinantes de piores escores de SF-36 em análise multivariada. CONCLUSÕES Mostramos que a presença de complicações da doença, a baixa adesão ao tratamento da terapia quelante de ferro e o baixo status econômico são preditores de pior QV em pacientes com ?-TM. Prevenção e manejo adequado das complicações relacionadas com a doença, aumento do conhecimento dos pacientes sobre a importância do gerenciamento de comorbidades e ter maior adesão ao tratamento quelante de ferro, considerando também o apoio psicossocial e financeiro, poderiam ser úteis para melhor lidar com esse estado de doença crônica. Abstract in english CONTEXT AND OBJECTIVE Patients with beta-thalassemia major (?-TM) experience physical, psychological and social problems that lead to decreased quality of life (QoL). The aim here was to measure health-related QoL and its determinants among patients with ?-TM, using the Short Form-36 (SF- [...] 36) questionnaire. DESIGN AND SETTING Cross-sectional study at the Hematology Research Center of Shiraz University of Medical Sciences, in southern Iran. METHODS One hundred and one patients with ?-TM were randomly selected. After the participants' demographics and disease characteristics had been recorded, they were asked to fill out the SF-36 questionnaire. The correlations of clinical and demographic factors with the QoL score were evaluated. RESULTS There were 44 men and 57 women of mean age 19.52 ± 4.3 years (range 12-38). On two scales, pain (P = 0.041) and emotional role (P = 0.009), the women showed significantly lower scores than the men. Lower income, poor compliance with iron-chelating therapy and presence of comorbidities were significantly correlated with lower SF-36 scores. These factors were also found to be determinants of worse SF-36 scores in multivariate analysis. CONCLUSIONS We showed that the presence of disease complications, poor compliance with iron-chelating therapy and poor economic status were predictors of worse QoL among patients with ?-TM. Prevention and proper management of disease-related complications, increased knowledge among patients regarding the importance of managing comorbidities and greater compliance with iron-chelating therapy, along with psychosocial and financial support, could help these patients to cope better with this chronic disease state.

Sezaneh, Haghpanah; Shiva, Nasirabadi; Fariborz, Ghaffarpasand; Rahmatollah, Karami; Mojtaba, Mahmoodi; Shirin, Parand; Mehran, Karimi.

68

A killer revealed: 10-year experience with beta-thalassemia intermedia.  

Science.gov (United States)

Objectives Patients with beta-thalassemia intermedia tend to present later in life with milder anemia than beta-thalassemia major patients. The incidence of mortality and its causes in this patient population remains unknown. We aim to reveal the incidence and most common causes of death in this population. Methods and results We reviewed the charts of all of the beta-thalassemia intermedia patients who had been followed at the Chronic Care Center in Hazmieh, Lebanon during a 10-year period. A total of 18 patients out of 127 had died during the follow-up period giving a cumulative 10-year mortality incidence of 14%. The most common causes of cardiac deaths were due to renal and cardiac causes. Discussion Most causes of death have been linked to the high levels of iron coupled with anemia present in this patient population. Many of deaths could be prevented by adequate treatment. Conclusion Larger studies with more comprehensive data capture on risk factors of mortality in this patient population are called for. PMID:24074485

Matta, Bassem N; Musallam, Khaled M; Maakaron, Joseph E; Koussa, Suzanne; Taher, Ali T

2014-06-01

69

Prevalence of hepatosplenomegaly in beta thalassemia minor subjects in Iran  

Energy Technology Data Exchange (ETDEWEB)

Introduction: Thalassemia is the most common hereditary blood disorder in the world. Iran is located on the thalassemic belt and there is a high prevalence of the hepatosplenomegaly in beta thalassemia minor patients which is reported to be very variable. The goal of this research was to study the frequency of these signs in the cases with beta thalassemia minor patients in Iran. Materials and methods: Two hundred and fifty-nine cases that referred to center for pre-marriage tests were divided into two groups according to their MCV, MCH, and HbA2 (beta thalassemia minor cases and control groups). Liver and spleen sizes were determined by ultrasonographic method and the two groups were compared with each other. Results: Average spleen volumes in case and control groups were 163.48 {+-} 133.97 and 126.29 {+-} 53.98 mm{sup 3}, respectively. Average spleen lengths in case and control groups were 10.71 {+-} 1.52 and 10.60 {+-} 5.4 cm, respectively. Conclusion: In the regions with high frequency of beta thalassemia, in case of finding large spleen size in the ultrasonography, a probable harmless differential diagnosis will be beta thalassemia minor that is not indicative of any serious disease. Volumetric measurement of spleen is more reliable for detection of splenomegaly in these patients.

Karimi, Mehran [Hemostasis and Thrombosis Unit, Hematology Research Center, school of Medicine, Shiraz University of medical sciences, Shiraz (Iran, Islamic Republic of)], E-mail: Karimim@sums.ac.ir; Bagheri, Mohammad Hadi [Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of); Tahmtan, Mehdi [Hemostasis and Thrombosis Unit, Hematology Research Center, school of Medicine, Shiraz University of medical sciences, Shiraz (Iran, Islamic Republic of); Shakibafard, Alireza [Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of); Rashid, Murtaza [Hemostasis and Thrombosis Unit, Hematology Research Center, school of Medicine, Shiraz University of medical sciences, Shiraz (Iran, Islamic Republic of)

2009-01-15

70

Hemoglobin E-beta thalassemia: factors affecting phenotype.  

Science.gov (United States)

The phenotype of E-beta-thalassemia is affected by several genetic factors. The aim of this study was to analyze severity of E-beta-thalassemia and correlate with HbE, HbF, E/F ratios, beta-mutation and Xmn I polymorphism. Thirty cases of E-beta-thalassemia (23 with childhood onset) were studied. HbE levels were quantitated by HPLC. Xmn1 polymorphism and beta-mutations were studied by PCR-RFLP and ARMS respectively. Commonest features were pallor (100%), splenomegaly (74%), and hepatomegaly (65%), 43% (10/23) were on regular transfusions at diagnosis. One case presented with paraplegia. Patients heterozygous for Xmn I polymorphism (+/-) had later onset (>3 yrs) compared to homozygous (-/-) absence (0.5-2.8 yrs). Most (69.6%) showed beta-mutation IVS 1-5 (G-->C). Negative correlation was found between age of onset and HbE. Thus, presentation is similar to previously reported Thai cases. Heterozygosity of Xmn I polymorphism also delays disease onset. Early diagnosis facilitates appropriate management and prenatal diagnosis. PMID:15876597

Panigrahi, I; Agarwal, S; Gupta, T; Singhal, P; Pradhan, M

2005-04-01

71

Prenatal diagnosis of beta-thalassemia among Indians using denaturing gradient gel electrophoresis.  

Science.gov (United States)

We have offered first trimester prenatal diagnosis to 55 couples at risk for beta-thalassemia, originating from various parts of India, using polymerase chain reaction and denaturing gradient gel electrophoresis. Apart from the six common mutations, codon 30 (CAG-->CAA), Cap site +1 (A-->C), as well as three uncharacterized mutations were seen among the parents. In the majority of cases, the diagnosis was possible by scanning only one fragment (B) where most of the Indian mutations are situated. In 18 out of 55 cases, framework analysis could also have been used to offer prenatal diagnosis without characterizing the beta-thalassemia mutations. In the two cases where the mutations were uncharacterized, prenatal diagnosis was done only on the basis of the anomalous denaturing gradient gel electrophoresis patterns seen in the parents and in previously affected children. This is the first attempt of prenatal analysis using denaturing gradient gel electrophoresis in the extremely diverse Indian population where the profile of mutations has not yet been fully elucidated. PMID:9322077

Gorakshakar, A C; Lulla, C P; Nadkarni, A H; Pawar, A R; Desai, S N; Colah, R B; Mohanty, D

1997-09-01

72

The liver in patients with [beta]-thalassemia major. Determination of iron concentration with Magnetic Resonance Imaging. Il fegato dei pazienti affetti da [beta]-talassemia major. Determinazione della concentrazione di ferro con Risonanza Magnetica  

Energy Technology Data Exchange (ETDEWEB)

The paper investigates the clinical usefulness of liver MRI in a large multicenter study because the control of iron concentration (LIC) is crucial in thalassemia major (TM) prognosis and conflicting results have been reported in small and heterogeneous groups of patients using MRI, the only very common non-invasive procedure. One hundred and eight consecutive TM patients, selected according to a specific protocol, were included in the study. This study shows that LIC can be calculated as a function of SIR. A validation study is necessary before introducing this prediction rule in clinical practice.

Midiri, M. (Bari, Policlinico Univ. (Italy). Ist. di Radiologia); Gallo, C.; Finazzo, M. (Palermo, Policlinico Univ. ' P. Giaccone' (Italy). Ist. di Radiologia ' Pietro Cignolini' )

73

Investigation of RBC Indices and HbA2 Levels in Parents of Beta-Thalassemia Patients: Impacts on Premarital Genetic Counseling  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: This study was designed to investigate RBC indices and HbA2 levels in parents of major beta-thalassemia patients to detect possible silent beta- thalassemia carriers and examine its potential impact on the premarital genetic counseling.Materials and Methods: This cross sectional study was performed at Children Medical Center from 2004 to 2006. After genetic counseling and getting informed consent, peripheral blood sampling was carried out on 185 carrier parents of regularly blood transfused thalassemia children. Then RBC indices and HbA2 concentration were measured. Samples with MCV and MCH higher than and/or HbA2 lower than cut off values were rechecked. Results: In one case, MCV and MCH indices were within the limits defined for non beta- thalassemia carriers. Furthermore, four other cases were found to have decreased values of MCV and MCH but normal HbA2 levels."nConclusion: About 3% of beta-thalassemia carriers in our country may potentially be missed using current screening methods. Further studies are required to assess the need for presenting a new threshold for thalassemia carrier screening. Defining the causative mutations using molecular methods would pave the way for establishing a protocol for a premarital screening program in conditions when one of couples is a confirmed carrier.

Mina Izadyar

2007-06-01

74

The molecular basis of normal HbA2 (type 2) beta-thalassemia in Greece.  

Science.gov (United States)

Heterozygotes for beta-thalassemia usually have raised levels of HbA2, but in Greece about 5% of beta-thalassemia carriers are observed to have normal or borderline levels. It is postulated that such cases have mild beta+ thalassemia mutations or coinheritance of delta-thalassemia. We selected 18 heterozygotes with the hematological phenotype of normal HbA2 (type 2) beta thalassemia who were negative for the delta beta Corfu mutation, and screened them for previously defined Mediterranean beta-thalassemia and delta-thalassemia mutations. The coinheritance of beta and delta-thalassemia was demonstrated in four cases with the following genotypes: in cis beta+ IVSII -n745/delta+ 27, beta 0NS39/delta 059(-A), beta+ IVSI-n110/delta 059(-A) and in trans beta+ IVSI-n6 and delta+ 27. A further nine heterozygotes had mild beta(+)-thalassemia mutations (eight with the beta+ IVSI-n6 mutation, one with the beta+ polyA (A-->G) mutation). In four heterozygotes with severe beta-thalassemia chromosomes (2 beta+ IVSI-n110, 1 beta 0 FSC-6, 1 beta 0 IVSI-n1) no known delta-thalassemia mutations were observed. One case had a delta beta deletion chromosome. These results indicate that the hematological phenotype of normal HbA2 (type 2) beta-thalassemia in Greece is genetically heterogeneous; it is mainly associated with the delta beta Corfu mutation or coinheritance of beta and delta thalassemia mutations or with very mild beta(+)-thalassemia mutations, mainly beta+ IVSI-n6. In the rare cases with severe beta-thalassemia mutations, the normal levels of HbA2 may be due to coinheritance of as yet undefined delta thalassemia mutations. PMID:8034555

Tzetis, M; Traeger-Synodinos, J; Kanavakis, E; Metaxotou-Mavromati, A; Kattamis, C

1994-01-01

75

[Beta-thalassemia and glucose-6-phosphate dehydrogenase deficiency].  

Science.gov (United States)

Twenty subjects--patients with anemia and their close relatives representing 7 families, were tested for thalassemia. Heterozygotic beta-thalassemia was detected in 17 cases. The national composition of this patient population was as follows: 7 Pathans (Afghanistan), 1 family; 2 Armenians (Georgia), mother and son; 2 Tajiks, sibs; 2 patients of mixed Russian-Ukrainian-Polish-Azerbaijan origin, mother and son; 1 Russian-Arab child and his Arab father (Syria); 1 Uzbek woman and 1 Russian child. The mean content of Hb in the blood for patients with heterozygotic beta-thalassemia is 110 +/- 3.8 g/liter, that of HbA2 fraction 4.8 +/- 0.26% and of HbF fraction 2.6 +/- 0.39%. Clinical manifestations of the disease varied, being more grave in children than in adults. In an Armenian family from Batumi thalassemia minor was diagnosed in the mother and son, whereas in the father and other son a periodic disease was revealed. In a family of 7 members from Afghanistan thalassemia minor was found in 4 representing the paternal line, minimal thalassemia was suspected in 3, and a deficiency of glucose-6-phosphate dehydrogenase in red blood cells was revealed in 5: in the mother and 4 children. No increase of methemoglobin level was revealed in either of the examinees. PMID:9044721

Troitskaia, O V; Ermil'chenko, G V; Levitskaia, S V; Varzieva, L K

1996-01-01

76

Molecular characterization of beta-thalassemia in Pakistan.  

Science.gov (United States)

Beta-thalassemia is one of the most common inherited hemoglobin disorders in Pakistan. The carrier frequency is estimated to be 5.4%. To determine the spectrum of beta-globin gene defects causing beta-thalassemia, we have analyzed a representative sample of 602 alleles from six ethnic groups in Pakistan; 99.2% alleles were characterized, while 0.8% remained unidentified. The spectrum of mutations is heterogeneous and we have found 19 different mutations in all ethnic groups. The four most common mutations, IVS-I-5 (G-->C) (37.7%), codons 8/9 (+G) (21.1%), the 619 bp deletion (12.4%), and IVS-I-1 (G-->T) (9.5%), account for 80.7% of the alleles. There are differences between the ethnic groups and also between provinces. In the four provinces of Pakistan, the IVS-I-5 (G-->C) mutation is more prevalent in Sindh and Balochistan, bordering India in the south and Iran in the southwest, while the codons 8/9 (+G) mutation is more common in the Punjab and the North West Frontier Province, bordering India in the northeast and Afghanistan, respectively. The 619 bp deletion is high (46%) in Gujratis and Memons residing in the Province of Sindh, neighboring the Indian Gujrat. PMID:9730364

Khan, S N; Riazuddin, S

1998-07-01

77

Diffuse Hepatic Calcifications in a Transfusion-Dependent Patient with Beta-Thalassemia: A Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Hepatic calcification is usually associated with infectious, vascular, or neoplastic processes in the liver. We report the first case of beta-thalassemia major with isolated diffuse hepatic calcification in a 23 year old woman, who had been transfusion-dependent since the age of 6 months. She was referred to our center with a chief complaint of abdominal pain. Computed tomography scan of the abdomen revealed diffuse hepatic calcification in the right, left, and caudate lobes of the liver. Her medical history disclosed hypoparathyroidism as well as chronic hepatitis C virus infection, which was successfully treated but led to early micronodular cirrhosis on liver biopsy. Other studies done to search for the cause of hepatic calcification failed to reveal any abnormalities. We suspect that hypoparathyroidism caused liver calcification, and should be, therefore, considered in the differential diagnosis of hepatic calcification if other causative factors have been ruled out.

Forough Saki

2013-09-01

78

Distribution of Hepatitis C Virus Genotypes Amongst the Beta-thalassemia Patients in North of Iran  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Beta-thalassemia patients have high prevalence for HCV infection. In developing countries, HCV antibody is reported to be high in this group of patients. This study carried out to determine the distribution of HCV genotypes amongst the beta-thalassemia patients in North of Iran. The present study has been carried out between February and March 2010 amongst a group of 245 beta-thalassemia patients (125 male and 120 female) referred to the hospitals Mazandaran and Guilan provinces for a blood t...

Masood Ghane; Mina Eghbali; Hamid Reza Nejad; Kivan Saeb; Maryam Farahani

2012-01-01

79

The Xmn1 polymorphic site 5' to the (G)gamma gene and its correlation to the (G)gamma:(A)gamma ratio, age at first blood transfusion and clinical features in beta-thalassemia patients from Western Iran.  

Science.gov (United States)

beta-Thalassemia is the most common single gene disorder in Iran and more than 25,000 affected individuals have been reported. It has been reported that in patients with beta-thalassemia in the presence of Xmn1 polymorphic site the level of Hb F and (G)gamma: (A)gamma ratio is increased. The prevalence of Xmn1 polymorphic site, (G)gamma: (A)gamma ratio and Hb F in 197 beta-thalassemia major patients from the Kermanshah Province of Iran were studied. The Xmn1 polymorphic site was determined by PCR-RFLP procedure. The levels of (G)gamma and (A)gamma chains were detected by HPLC. The percent of Hb F was determined using electrophoresis method. In beta-thalassemia major patients the frequency of presence Xmn1 was 0.39. The mean of (G)gamma: (A)gamma ratio was found to be 2.5. In the present study it was found that in the presence of Xmn1 polymorphic site (G)gamma percent and (G)gamma: (A)gamma ratio were significantly increased (P = 0.01) and the clinical features such as splenomegaly and bone marrow expansion were significantly improved (P = 0.01). We found that in the presence of Xmn1 polymorphic site on both chromosomes (+/+) the level of Hb F tended to be increased compared to the absence of Xmn1 (-/-). The present investigation has studied the frequency of Xmn1 polymorphic site in beta-thalassemia major patients from Western Iran and has revealed that the presence of this polymorphic site caused a positive influence on Hb F production and the (G)gamma percent which could improve the clinical symptoms of beta-thalassemia patients. PMID:19444645

Nemati, Hooshang; Rahimi, Zohreh; Bahrami, Gholamreza

2010-01-01

80

Adipocytokine concentrations in children with different types of beta-thalassemia.  

Science.gov (United States)

Abstract Background. Beta-thalassemia is an inherited blood disorder. It results from the impaired production of ?-globin chains, leading to a relative excess of alpha-globin chains. Clinical severity separates this disease into three main subtypes: ?- thalassemia major, ?-thalassemia intermedia and ?-thalassemia minor, the former two being clinically more significant. Inflammatory processes may play an important role in some of the complications of thalassemia. Adipose tissue is one of the most important endocrine and secretory organs that release adipocytokines like adiponectin, resistin and visfatin. Aim. The aim of our study was to analyze adipocytokine concentrations (adiponectin, resistin and visfatin) in different types of ?-thalassemia patients and determine any possible correlations with disease severity. Methods. We recruited 29 patients who were transfusion-dependent ?-thalassemia-major patients, 17 patients with ?-thalassemia intermedia, 30 ?-thalassemia minor patients. The control group consisted of 30 healthy children. Anthropometric measurements, complete blood count, biochemical parameters, serum concentrations of adiponectin, resistin, visfatin were performed for all subjects. Results. Resistin and visfatin concentrations were significantly higher in ?-thalassemia minor patients than in controls. Adiponectin, resistin and visfatin concentrations were significantly higher in both ?-thalassemia intermedia and major patients than in controls. The concentrations of adiponectin, resistin and visfatin were significantly higher in both ?-thalassemia intermedia and major patients than in ?-thalassemia minor patients. There was no significant difference between ?-thalassemia intermedia and ?-thalassemia major patients for adipocytokines concentrations. Conclusion. We speculate that these adipocytokines may play a role in the development of complications in ?-thalassaemia. PMID:24564631

Enli, Ya?ar; Balci, Yasemin I; Gönen, Cafer; Uzun, Ebru; Polat, Aziz

2014-06-01

 
 
 
 
81

Characterization of a spontaneous mutation to a beta-thalassemia allele.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We have studied a nuclear family containing a single child with severe beta-thalassemia intermedia, a Greek-Cypriot mother with hematological findings of beta-thalassemia trait, and a Polish father who is hematologically normal. Since both the child and her father were heterozygous for a DNA polymorphism within the beta-globin gene, it was possible to clone and sequence the beta-globin gene identical by descent from both the child and her father. A nonsense mutation in codon 121 (GAA----TAA) ...

1986-01-01

82

THE Hb S/beta+ -thalassemia phenotype demonstrates that the IVS-I (-2) (A>C) mutation is a mild beta-thalassemia allele.  

Science.gov (United States)

We report a family in which two siblings are compound heterozygotes for Hb S [beta6(A3)GluVal] and a rare beta-globin mutation [IVS-I (-2) (A>C)]. Both patients had significant levels of Hb A, indicating that the IVS-I (-2) mutation is a relatively mild beta(+)-thalassemia (beta(+)-thal) allele. This mutation, in compound heterozygosity with Hb S, does not necessarily lead to a mild clinical course. PMID:18473247

Schmugge, Markus; Waye, John S; Basran, Raveen K; Zurbriggen, Karin; Frischknecht, Hannes

2008-01-01

83

Beta globin gene cluster haplotypes of the beta thalassemia mutations observed in the Denizli province of Turkey  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Our aim was to identify the beta globin gene cluster haplotypes for the beta thalassemia mutations in Turkey on a regional level. Beta thalassemia mutations included in this study were IVS-I-110 (G>A, FSC 8/9 (+G, IVS-II-1 (G>A, IVS-I-5 (G>C, IVS-I-1 (G>A, IVS-I-6 (T>C, and FSC 8 (-AA. Methods: We studied 22 unrelated patients with ?-thalassemia major and 72 unrelated healthy subjects from our Department’s DNA bank. Haplotype analysis was done by polymerase chain reaction (PCR-based restriction enzyme digestion for the beta globin gene cluster of the following polymorphic restriction sites: Hinc II 5’ to ?, Hind III 5’ to G?, Hind III in the IVS-II 5’ to A?, Hinc II in pseudo ?, Hinc II 3’ to pseudo ?, Ava II in ?, and Hinf I 3’ to ?. Associated haplotypes for the normal control samples (72 individuals, 144 chromosomes were determined by Arlequin 3.1 software with unknown gametic phase.Results: According to the results obtained, the most frequent beta globin gene cluster haplotypes in the normal population were (+----++, (+----+-, (-+-++++, and (+-----+, with frequencies of 28.6%, 17.2%, 9.8%, and 8.3%, respectively. IVS-I-110 mutation was linked with the haplotypes (+----++ and (+-----+. Observed haplotypes were (+----++ for FSC 8/9 (+G, (-+-+++- for IVS-II-1 (G>A, (-+-++-+ and -+-++++ for IVS-I-5 (G>C, (+----+- and +------ for IVS-I-1 (G>A, (-++---+ for IVS-I-6 (T>C, and (+-----+ for FSC 8 (-AA.Conclusion: Our region shows the Mediterranean character for the beta thalassemia mutations. According to the obtained results, IVS-I-110 (G>A mutation linked with haplotype VII (+-----+, IVS-I-5 (G>C mutation with haplotype IV (-+-++-+, and codon 8/9 (+G with haplotype I (+----++ were shown for the first time in the Turkish population. The linkage of haplotype (+------ with the IVS-I-1 (G>A mutation is reported for the first time in the published literature. In the Denizli province of Turkey, beta globin gene cluster haplotypes of the normal population are strongly associated with the haplotypes of I (+----++, V (+----+- and IX (-+-++++, respectively.

Anzel Bahad?r

2009-09-01

84

Fusobacterium nucleatum prosthetic hip infection in an adult with sickle cell-beta thalassemia.  

Science.gov (United States)

Fusobacterium nucleatum is an anaerobic Gram-negative bacillus commensal to the human oropharynx and gastrointestinal tract which causes an array of human infection, yet it has never been associated with infection of prosthetic joints. We report the first case of prosthetic hip infection caused by F. nucleatum in a man with sickle cell-beta thalassemia. PMID:22002730

Verma, K; McNabb, P C; Kurtz, W; Green, J; Trabue, C H

2012-06-01

85

Distribution of Hepatitis C Virus Genotypes Amongst the Beta-thalassemia Patients in North of Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Beta-thalassemia patients have high prevalence for HCV infection. In developing countries, HCV antibody is reported to be high in this group of patients. This study carried out to determine the distribution of HCV genotypes amongst the beta-thalassemia patients in North of Iran. The present study has been carried out between February and March 2010 amongst a group of 245 beta-thalassemia patients (125 male and 120 female referred to the hospitals Mazandaran and Guilan provinces for a blood transfusion. Qualitative analysis of these samples using ELISA and PCR. The PCR positive samples were subjected to genotyping by RFLP method. Of total 245 beta-thalassemia patients who were the subjects of this study, 28 of these patients were diagnosed through PCR test to have RNA virus. For this reason, the prevalence of this illness in this study group was estimated as 11.42%. By using the RFLP technique, the above genotyping were identified and the prevalence of three genotypes, including 3a, 1a and 1b were proved. The genotype 3a was most prevalent. Out of 28 positive samples, 18 (64.3% samples had this genotype. After that, genotype 1a with 9 positive occurrences (32.1% and genotype 1b with only 1 positive occurrence (3.6% were most prevalent. This study demonstrated that the main reason the beta-thalassemia patients became infected with the genotype of the virus was due to receiving infected blood that entered into Iran during the past two decades.

Maryam Farahani

2012-01-01

86

A SINGLE NUCLEOTIDE POLYMORPHISM IN THE HBBP1 GENE IN THE HUMAN beta-GLOBIN LOCUS IS ASSOCIATED WITH A MILD beta-THALASSEMIA DISEASE PHENOTYPE  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The rs2071348 (g.5264146A>C) polymorphism on the HBB pseudogene, namely HBBP1, previously emerged as a variant significantly associated with a milder disease phenotype in Asian beta(0)-thalassemia/hemoglobin (Hb) E (beta(0)-thal/Hb E [beta 26(B8)Glu -> Lys, GAG>AAG]) patients. In this study, we aimed to explore the possible association of rs2071348 with beta-thalassemia (beta-thal) disease severity in a group of beta-thal major (beta-TM) patients (severe phenotype) and beta-thal intermedia (b...

2012-01-01

87

Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Iron deficiency and heterozygous beta-thalassemia are important causes of hypochromic-microcytic anemia. Two laboratory parameters are suggested for the differentiation of such anemia. High-fluorescence reticulocyte counts and soluble transferrin receptor levels were determined in iron-deficiency anemia patients (n = 49) and heterozygous beta-thalassemia patients (n = 43). There was no significant difference in high-fluorescence reticulocyte and soluble transferrin receptor values between the...

2003-01-01

88

Effect of pregnancy on differentiation of minor Beta-Thalassemia from iron deficiency  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Differential diagnosis of Iron-deficiency anemia and Beta-Thalassemia, two common causes of anemia, affects the treatment in pregnant women. To help the diagnosis, we have tried to asses the pure effect of gestation on diagnostic criteria, eliminating iron and folate deficiency. In a prospective study, 46 thalassemic women were given Ferrous Sulphate tablets and Folate. Some indices, CBC and HbA2 were measured before and after treatment during pregnancy. The haemoglobin and HbA2 decreased and...

Ghanei M

1997-01-01

89

What is beta-thalassemia?, 2D animationSite: DNA Interactive (www.dnai.org)  

Science.gov (United States)

The HBB gene encodes an important blood protein called beta globin. A person with beta-thalassemia carries a mutation in both copies of the HBB gene, completely halting production of the beta globin protein. Without beta globin, the important oxygen-carrying protein, hemoglobin, can not be made. Although oxygen can be carried by a less efficient form of hemoglobin, most of the affected red blood cells die.

2008-10-06

90

What causes beta-thalassemia?, 2D animationSite: DNA Interactive (www.dnai.org)  

Science.gov (United States)

The HBB gene encodes an important blood protein called beta globin. A person with beta-thalassemia carries a mutation in both copies of the HBB gene, completely halting production of the beta globin protein. Without beta globin, the important oxygen-carrying protein, hemoglobin, can not be made. Although oxygen can be carried by a less efficient form of hemoglobin, most of the affected red blood cells die.

2008-10-06

91

Prevention of homozygous beta-thalassemia by carrier screening and prenatal diagnosis in Sardinia.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We report here results of a 3-year pilot voluntary screening program coupled with prenatal diagnosis directed to the prospective prevention of homozygous beta-thalassemia (beta-thal) in Sardinia. The screening program took two approaches: outreach community testing and hospital testing on request after a period of sensibilization. The outreach testing was very effective as, taking into account the already known number of couples at risk with an affected proband (20), 74% of the couple at risk...

1981-01-01

92

Identification of the multiple beta-thalassemia mutations by denaturing gradient gel electrophoresis.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We used denaturing gradient gel electrophoresis to detect the beta-thalassemia mutations in the Chinese population. By amplifying the beta-globin gene in four separate fragments and electrophoresing the amplified DNA in two gels, we were able to distinguish all the 12 known mutations on the basis of the mobility of the homoduplexes and heteroduplexes. We conclude that denaturing gradient gel electrophoresis offers a nonradioactive means of detecting multiple mutations in genetic disorders.

Cai, S. P.; Kan, Y. W.

1990-01-01

93

A significant beta-thalassemia heterogeneity in the United Arab Emirates.  

Science.gov (United States)

The Dubai Thalassemia Center has identified 35 different beta-thalassemia mutations in 570 chromosomes from the United Arab Emirates population using gene amplification, hybridization with specific labeled oligonucleotide probes, sequencing of amplified DNA, restriction enzymes, and amplification refractory mutation system techniques. This large number of mutations which represent 21% of the total beta-mutations discovered worldwide reflects the heterogenous nature of the population living in the United Arab Emirates (1). We found that 50% of our beta-thalassemia patients have a concomitant alpha-thalassemia; namely the -alpha 3.7 kb deletion. Co-inheritance of alpha-thalassemia especially in the form of two alpha-globin gene deletions have an ameliorating effect on the phenotype presentation of our beta-thalassemia. Nine patients (one homozygote and eight compound heterozygotes) were identified with Hb Monroe (IVS-I,-1 (G-->C)), a thalassemic hemoglobin characterized by an Arg-->Thr substitution in codon 30 of the beta-globin gene. In addition, one of the patients was a compound heterozygote for Hb Tacoma [IVS-I, +1 (G-->C)]; a point mutation affecting the third nucleotide of codon 30 (G-->C) causing an Arg-->Ser replacement. PMID:9140720

el-Kalla, S; Mathews, A R

1997-05-01

94

Rare association between two genetic conditions: turner syndrome and beta thalassemia minor  

Directory of Open Access Journals (Sweden)

Full Text Available Rare disorders are defined as diseases, including those of genetic origin, which are life-threatening or chronically debilitating, which are of such low prevalence that special combined efforts are needed to address them. We present a case with a rare association between two genetic conditions: Turner phenotype and beta thalassemia minor. Turner syndrome is a chromosomal disorder that is characterized by the absence of all or part of a second sex chromosome in some or all cells. This condition occurs in 1 in 2,500 to 3,000 girls. The physical features include webbing of the neck, short stature, delayed growth of the skeleton, broad chest, cardivascular abnormalities and gonadal dysgenesis. Women with this disorder are usually infertile due to ovarian failure. The clinical diagnosis was confirmed by the cytogenetic and by FISH analysis, which revealed the presence of only one X chromosome. Treatment may include human growth hormone and estrogen replacement therapy. On the other hand, thalassemias are genetic conditions that result from imbalance in the normal coordinated synthesis of the globin subunits that make up the hemoglobin tetramer, leading to decreased and defective production of hemoglobin. Beta thalassemia syndromes are hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains. Beta thalassemia is inherited in an autosomal recessive manner. Thalassemia minor usually presents as an asymptomatic mild microcytic anemia, but our case also had splenomegaly and required splenectomy.

Dorina STOICANESCU

2009-11-01

95

Beta-thalassemia- institution based analysis of ethnic and geographic distribution, effect of consanguinity and safety of chorionic villus sampling as a diagnostic, tool for pre-natal diagnosis in selected patients  

International Nuclear Information System (INIS)

To study the ethnic and geographic distribution of Beta-thalassemia amongst the patients included and to study the effect of consanguinity in promoting this disease. Also, to establish the safety of CVS when used as a pre-natal diagnostic tool in aiding the early diagnosis of Beta-thalassemia in selected patients. Study Design: Descriptive Study. Place and Duration of Study: PNS Shifa Karachi, from Jan 2008 to Dec 2008. Patients and Methods: A total of 223 women out of 240 that were referred from all over Sindh to PNS Shifa Hospital Karachi for susceptible gene mutations participated in the study. The standard procedure that was used in this study was trans-abdominal aspiration of chorionic villi through suction needle. The samples were then sent for further analysis to the Pathology Department at PNS Shifa Hospital Karachi. Results: In our study population Beta-thalassemia was most prevalent in Sindhi 107 (48%) followed by Punjabi 46 (21%), 27 (12%) Pathan, and 43 (19%) Balochi. Out of 223 women, 95 were of thalassemia trait, while 85 were of thalassemia major. Fifty five percent of thalassemia trait and 56% of thalassemia major fetus parents were first cousins. The rate of pregnancy loss after performing CVS was 2.0% with no complications reported. Conclusion: It is concluded that highest percentage of thalassemia is in first cousins and sindhi origin families are mostly affected. However CVS is a safe and effective tool for prenatal diagnosis and subsequent counselling in selected couples. (author)

2011-06-01

96

The validity of pallor as a clinical sign of anemia in cases with beta-thalassemia.  

Science.gov (United States)

Pallor is deemed useful in the evaluation of patients suspected of anemia, although its perceived presence or absence may be misleading in cases with increased pigmentation with iron, melanin, or bilirubin. The purpose of this study was to determine the validity of pallor in the detection of anemia in children with beta-thalassemia as an iron overload model. Patients with beta-thalassemia A aged 2 to 32 years who were admitted to the Hematology Unit, Department of Pediatrics, Ihsan Do?ramaci Children's Hospital, Ankara, Turkey were assessed for the presence of pallor in three anatomic sites (palm, conjunctiva, buccal mucosa) by a trained pediatrician. Overall, 105 observations were done. The mean age of the patients was 14.7 +/- 6.5 years. The mean hemoglobin (Hb) value was 10.0 +/- 1.2 g/dl (range: 5.4-12.6 g/dl). The sensitivities of palmar, buccal and conjunctival pallor for identifying thalassemic children with anemia were 93.2, 80.7 and 90.9%, respectively. Cases with Hb values less than 11 g/dl could be easily detected by conjunctival pallor, independent of serum ferritin levels. However, there were significant associations between the presence of palmar or buccal pallor and the presence of anemia in children with serum ferritin levels lower than 2500 microg/L. Palmar pallor alone had the highest sensitivity and lowest specificity to detect anemia in cases with beta-thalassemia. Conjunctival pallor was more useful than buccal and palmar pallor in cases with high ferritin levels. Further studies are necessary to detect the validity of pallor in different underlying diseases with anemia. PMID:18246743

Yalçin, S Songül; Unal, Selma; Gümrük, Fatma; Yurdakök, Kadriye

2007-01-01

97

Effect of pregnancy on differentiation of minor Beta-Thalassemia from iron deficiency  

Directory of Open Access Journals (Sweden)

Full Text Available Differential diagnosis of Iron-deficiency anemia and Beta-Thalassemia, two common causes of anemia, affects the treatment in pregnant women. To help the diagnosis, we have tried to asses the pure effect of gestation on diagnostic criteria, eliminating iron and folate deficiency. In a prospective study, 46 thalassemic women were given Ferrous Sulphate tablets and Folate. Some indices, CBC and HbA2 were measured before and after treatment during pregnancy. The haemoglobin and HbA2 decreased and MCV increased, all with significant P value. We concluded that HbA2, independent of iron, will decrease during pregnancy and MCV will increase

Ghanei M

1997-07-01

98

A beta-thalassemia lesion abolishes the same Mst II site as the sickle mutation.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Digestion of DNA from a patient with homozygous beta zero thalassemia from Calabria, Italy with the restriction endonuclease Mst II produced a pattern similar to the one obtained with sickle cell trait DNA in that the Mst II site at the beta 6 position on one chromosome was abolished. We cloned the DNA from this beta-thalassemia chromosome and performed sequence analysis. The deletion of a single nucleotide (A) at the GAG codon of the beta 6 position results in a frame shift and early beta-gl...

Chang, J. C.; Alberti, A.; Kan, Y. W.

1983-01-01

99

Characterization of beta-thalassemia mutations in patients from the state of Rio Grande do Norte, Brazil  

Digital Repository Infrastructure Vision for European Research (DRIVER)

35 unrelated individuals were studied for characterization as either heterozygous or homozygous for beta-thalassemia. Molecular analysis was done by PCR/RFLP to detect the mutations most commonly associated with beta-thalassemia (?0IVS-I-1, ?+IVS-I-6, and ?039). In the patients who showed none of these mutations, the beta-globin genes were sequenced. Of the 31 heterozygous patients, 13 (41.9%) had the ?+IVS-I-6 mutation, 15 (48.4%) the ?0IVS-I-1 mutation, 2 (6.5%) the ?+IVS-I-110 mutati...

2011-01-01

100

Characterization of beta-thalassemia mutations in patients from the state of Rio Grande do Norte, Brazil  

Digital Repository Infrastructure Vision for European Research (DRIVER)

35 unrelated individuals were studied for characterization as either heterozygous or homozygous for beta-thalassemia. Molecular analysis was done by PCR/RFLP to detect the mutations most commonly associated with beta-thalassemia (?0IVS-I-1, ?+IVS-I-6, and ?039). In the patients who showed none of these mutations, the beta-globin genes were sequenced. Of the 31 heterozygous patients, 13 (41.9%) had the ?+IVS-I-6 mutation, 15 (48.4%) the ?0IVS-I-1 mutation, 2 (6.5%) the...

2011-01-01

 
 
 
 
101

A comprehensive molecular characterization of beta thalassemia in a highly heterogeneous population.  

Science.gov (United States)

In Iran, the prevalence of beta-thalassemia trait is approximately 4-8% in most areas, and in Mazandaran province 10% of the population are carriers. Twenty four beta-globin gene mutations were identified in 1635 persons with beta-thalassemia trait using reverse dot blot and restriction fragment length polymorphism analysis. The predominant mutations included IVSII-1 (G-A) (61%), codon 30 (G-C) (7.5%), codon 22 (-7bp) (6.2%), codon 8 (-AA) (5.4%) and IVSI-5 (G-C) (3.6%). These mutations were in different haplotypes, with IVSII-1 being the most heterogeneous. Other less frequent mutations included IVS-II-745 (C-G), codon 44 (-C), codon 39 (C-T), codon 5 (-CT), IVS I-110 (G-A), IVSI-130 (G-C), Fr8/9 (+G), IVSI-1 (G-A), and IVSI (-25bp). All rare mutations except IVSI-130 were encountered in a unique haplotype. The diversity of these mutations reflects the historical admixture of genes in the region. The high prevalence of IVSII-1 (G-A) compared to other parts of the country and the world suggests a founder effect. Our data provide a basis for genetic counseling and prenatal diagnosis. PMID:21493114

Akhavan-Niaki, Haleh; Derakhshandeh-Peykar, Poupak; Banihashemi, Ali; Mostafazadeh, Amrollah; Asghari, Beheshteh; Ahmadifard, Mohammad-Reza; Azizi, Mandana; Youssefi, Ali; Elmi, Maryam Mitra

2011-06-15

102

Pregnancy and beta-thalassemia: an Italian multicenter experience  

Digital Repository Infrastructure Vision for European Research (DRIVER)

BACKGROUND: Recent advances in the management of thalassemia have significantly improved life expectancy and quality of life of patients with this hemoglobinopathy, with a consequent increase in their reproductive potential and desire to have children. DESIGN AND METHODS: We describe the methods of conception and delivery, as well as the course and outcome of pregnancy including transfusions, iron overload and chelation in 46 women with thalassemia major (58 pregnancies) and in 11 women with ...

Piga, Antonio Giulio

2010-01-01

103

Arterial ischemic stroke in a child with beta-thalassemia trait and methylentetrahydrofolate reductase mutation.  

Science.gov (United States)

Genetic and acquired disorders that foster a procoagulable state represent risk factors for stroke in childhood. Although an increased incidence of thromboembolic complications has been reported in patients with thalassemia, severe cerebral thromboembolism has rarely been observed in patients with beta-thalassemia minor. This article describes a case study of a 1-year-old boy who presented with left-sided hemiparesis, seizures, microcytic anemia, and recent infection with reactive thrombocytosis. Ischemic infarction in the territory of the right middle cerebral artery was confirmed by magnetic resonance imaging and magnetic resonance angiography. Genetic tests showed that the patient was heterozygous for the beta(degrees) -thalassemia IVS-I-1 mutation and homozygous for the methylentetrahydrofolate reductase C677T mutation. Based on these findings, it was concluded that the synergistic effects of multiple, genetic, and acquired prothrombotic risk factors brought about the hypercoagulable state that resulted in overt stroke in a thalassemic patient in early childhood. PMID:17621484

Brankovic-Sreckovic, Vesna; Milic Rasic, Vedrana; Djordjevic, Valentina; Kuzmanovic, Milos; Pavlovic, Sonja

2007-02-01

104

Regional and ethnic distribution of beta thalassemia mutations and effect of consanguinity in patients referred for prenatal diagnosis  

International Nuclear Information System (INIS)

To determine the regional and ethnic distribution of beta thalassemia mutation and the effect of consanguinity in patients referred for prenatal diagnosis of beta b-thalassemia and to target the high risk population for screening. A total of 499 couples were referred to Gentec Lab., Lahore, from all over Pakistan for prenatal diagnosis of b-thalassemia. After counseling, chorionic villus sampling was done between 10-16 weeks of gestation. DNA analysis was done by Amplification Refractory Mutation System (ARMS) for type of mutation in the Armed Forces Institute of Pathology, Rawalpindi. Ethnicity, race and consanguineous relationship of parents was determined.b-thalassemia was prevalent in Punjabis (60.7%) followed by Saraikees (25.5%). Castewise it was most frequent in Rajputs followed by Jatts, Arain, Sheikhs and Pathans. 56.7% of the couples were first cousins and 19.8% were relatives. The commonest mutations were Frameshift 8-9 (Fr8-9) 33.5%, Intervening Sequence 1-5 (IVS 1-5) 17.2%, Fr4142 - 8%, IVS 1-1 - 5.2%, Deletion 619 (Del 619) 4.2% and Codon 5 (Cd 5) - 4.2%. In samples sent for analysis, 53.1% turned out to be carriers (trait), 25.3% were diseased (thalassemia major) and 21.6% were normal. P-value of all results was less than 0.001. In this series, the highest frequency was found in Punjabi Rajputs. The commonest mutation was Fr 8-9. Most parents were first cousins. Premarital thalassemia carrier testing can effectively reduce the disease. (author)

2007-03-01

105

The effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

BACKGROUND: Thalassemia is the most common hereditary disease in the world. Thalassemic erythrocytes are exposed to higher oxidative stress and lipid peroxidation. The aim of this study was to investigate the effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients.
METHODS: A prospective double-blind, placebo-controlled study of the effect of beta-carotene and vitamin E on lipi...

Soleiman Mahjoub; Ahmad Tamaddoni; Maseoud Zanjanchi Nikoo; Ali Akbar Moghadamnia

2007-01-01

106

Characterization of beta-thalassemia mutations in patients from the state of Rio Grande do Norte, Brazil  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english 35 unrelated individuals were studied for characterization as either heterozygous or homozygous for beta-thalassemia. Molecular analysis was done by PCR/RFLP to detect the mutations most commonly associated with beta-thalassemia (?0IVS-I-1, ?+IVS-I-6, and ?039). In the patients who showed none of th [...] ese mutations, the beta-globin genes were sequenced. Of the 31 heterozygous patients, 13 (41.9%) had the ?+IVS-I-6 mutation, 15 (48.4%) the ?0IVS-I-1 mutation, 2 (6.5%) the ?+IVS-I-110 mutation and 1 (3.2%) the ?+IVS-I-5 mutation. IVS-I-6 was detected in the four homozygotes. The mutation in codon 39, often found in previous studies in Brazil, was not detected in the present case. This is the first study aiming at identifying mutations that determine beta-thalassemia in the state of Rio Grande do Norte.

Zama Messala Luna da, Silveira; Maria das Vitórias, Barbosa; Thales Allyrio Araújo de Medeiros, Fernandes; Elza Miyuki, Kimura; Fernando Ferreira, Costa; Maria de Fátima, Sonati; Ivanise Marina Moretti, Rebecchi; Tereza Maria Dantas de, Medeiros.

107

Characterization of beta-thalassemia mutations in patients from the state of Rio Grande do Norte, Brazil  

Directory of Open Access Journals (Sweden)

Full Text Available 35 unrelated individuals were studied for characterization as either heterozygous or homozygous for beta-thalassemia. Molecular analysis was done by PCR/RFLP to detect the mutations most commonly associated with beta-thalassemia (?0IVS-I-1, ?+IVS-I-6, and ?039. In the patients who showed none of these mutations, the beta-globin genes were sequenced. Of the 31 heterozygous patients, 13 (41.9% had the ?+IVS-I-6 mutation, 15 (48.4% the ?0IVS-I-1 mutation, 2 (6.5% the ?+IVS-I-110 mutation and 1 (3.2% the ?+IVS-I-5 mutation. IVS-I-6 was detected in the four homozygotes. The mutation in codon 39, often found in previous studies in Brazil, was not detected in the present case. This is the first study aiming at identifying mutations that determine beta-thalassemia in the state of Rio Grande do Norte.

Zama Messala Luna da Silveira

2011-01-01

108

Characterization of beta-thalassemia mutations in patients from the state of Rio Grande do Norte, Brazil.  

Science.gov (United States)

35 unrelated individuals were studied for characterization as either heterozygous or homozygous for beta-thalassemia. Molecular analysis was done by PCR/RFLP to detect the mutations most commonly associated with beta-thalassemia (?(0)IVS-I-1, ?(+)IVS-I-6, and ?(0)39). In the patients who showed none of these mutations, the beta-globin genes were sequenced. Of the 31 heterozygous patients, 13 (41.9%) had the ?(+)IVS-I-6 mutation, 15 (48.4%) the ?(0)IVS-I-1 mutation, 2 (6.5%) the ?(+)IVS-I-110 mutation and 1 (3.2%) the ?(+)IVS-I-5 mutation. IVS-I-6 was detected in the four homozygotes. The mutation in codon 39, often found in previous studies in Brazil, was not detected in the present case. This is the first study aiming at identifying mutations that determine beta-thalassemia in the state of Rio Grande do Norte. PMID:21931514

da Silveira, Zama Messala Luna; das Vitórias Barbosa, Maria; de Medeiros Fernandes, Thales Allyrio Araújo; Kimura, Elza Miyuki; Costa, Fernando Ferreira; de Fátima Sonati, Maria; Rebecchi, Ivanise Marina Moretti; de Medeiros, Tereza Maria Dantas

2011-07-01

109

Compliance and satisfaction with deferasirox (Exjade(®)) compared with deferoxamine in patients with transfusion-dependent beta-thalassemia.  

Science.gov (United States)

Objective The current standard option for iron chelation therapy (ICT) in transfusion-dependent patients with beta-thalassemia is deferoxamine (DFO). We aimed to compare the compliance with DFO vs. deferasirox (Exjade(®)), a novel oral iron chelator, in patients with transfusion-dependent beta-thalassemia. Methods In this cross-sectional study, 220 patients from Southern Iran who were receiving DFO or Exjade(®) for the last 2 years were investigated in 2012. Satisfaction, compliance, convenience, and life disturbances of the patients with ICT were evaluated. Assessments were performed at four different occasions during 1 year. Results According to the results, 114 patients received treatment with DFO and 106 patients were treated with Exjade(®). In comparison with the patients who were treated with DFO, those receiving Exjade(®) reported a significantly higher rate of compliance and convenience (P  0.05). In the DFO group, 44.9% of the patients reported irritation and pain at the injection site. Conclusions Considering higher rate of compliance and convenience with Exjade(®) and the comparable efficacy of these two modalities of ICT documented in previous studies, Exjade(®) can be used as a preferable choice of ICT in iron-overload patients with beta-thalassemia. PMID:24074344

Haghpanah, Sezaneh; Zarei, Tahereh; Zahedi, Zohreh; Karimi, Mehran

2014-06-01

110

Coexisting iron deficiency anemia and Beta thalassemia trait: effect of iron therapy on red cell parameters and hemoglobin subtypes.  

Science.gov (United States)

Background. Coexistence of iron deficiency anemia (IDA) and beta thalassemia trait (BTT) has been the topic of few studies. However, no study from our country was found evaluating the effect of iron therapy in patients with concomitant IDA and BTT. Methods. Over a period of two years, 30 patients with concomitant IDA and BTT were included. All the patients had a complete blood count, serum iron studies, and thalassemia screening using BIORADTM hemoglobin testing system. The patients received oral iron therapy in appropriate dosages for a period of twenty weeks, after which all the investigations were repeated. Appropriate statistical methods were applied for comparison of pre- and posttherapy data. Results. All except two patients were adults with a marked female preponderance. Oral iron therapy led to statistically significant improvement in hemoglobin, red cell indices (P anemia in patients with beta thalassemia trait, which can potentially confound the diagnosis of the latter. Hence, iron deficiency should be identified and rectified in patients with suspicion of beta thalassemia trait. PMID:25006473

Verma, Sarika; Gupta, Ruchika; Kudesia, Madhur; Mathur, Alka; Krishan, Gopal; Singh, Sompal

2014-01-01

111

Multiple transfused thalassemia major: Ocular manifestations in a hospital-based population  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Purpose: To study the ocular manifestations in multiple transfused beta-thalassemia major patients and assess the ocular side-effects of iron chelating agents. Materials and Methods: In this prospective observational study, 45 multiple transfused beta-thalassemia major children between six months and 21 years of age were enrolled and assigned groups according to the treatment regimens suggested. Group A received only blood transfusions, Group B blood transfusions with subcuta...

2010-01-01

112

Thalassemia major: A report of two cases with severe skeletal involvement  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Beta thalassemia major is rare in Serbia. Previously incurable, affected patients now live to adulthood with regular blood transfusions. The improvement in supportive treatment over recent decades has given rise to many more patients suffering from the associated metabolic complications of anemia and iron overload, such as osteopenia and other skeletal changes. We present two patients with severe beta thalassemia major from early childhood, who encountered pathological long-bone fractures dur...

Leši? A.; Bogdanovi? A.; Su?i? V.; Suvajdži?-Vukovi? N.; Atkinson H.D.E.; Bumbaširevi? M.

2010-01-01

113

beta-Thalassemia mutations in the Iranian Kurdish population of Kurdistan and West Azerbaijan provinces.  

Science.gov (United States)

The aim of this study was to investigate the prevalence and spectrum of beta-thalassemia (beta-thal) mutations in the population of Sunni Muslim Kurds in western Iran and to set up a prenatal diagnostic laboratory. Sixty unrelated Kurdish beta-thal patients identified in hematology clinics from different cities were studied. The mutations in 120 chromosomes were studied by polymerase chain reaction-amplification refractory mutation system and direct sequencing methods. We found fifteen beta-thal mutations, and IVS-II-1 (G>A) was the most frequent, comprising 35% of all mutations. Other common mutations were frameshift codons 8/9 (+G) 15.7%, IVS-I-1 (G>A) 8%, FSC 5 (-CT) 6.7%, FSC 8 (-AA) 6.7%, and IVS-I-110 (G>A) 6%. This is the first comprehensive study in this region and could provide a reference for prenatal testing and genetic counseling in this population. PMID:19373586

Haghi, Mehdi; Khorshidi, Shohre; Hosseinpour Feizi, Mohammad Ali; Pouladi, Nasser; Hosseinpour Feizi, Abbas A

2009-01-01

114

Peripheral Blood stem cell transplantation in children with Beta-thalassemia major  

International Nuclear Information System (INIS)

Objective: To share the preliminary data on stem cell transplantation in Pakistan. Results: Engraftment was achieved in all patients except one who required a second dose of bone marrow graft on day +21. Median time to achieve absolute neutrophil count of > 0.5 x 10/sup 9/ /l was 9.0 days (range 8 - 31 days) and platelet count of > 20 x 10/sup 9/ /l was 14 days (12 - 35 days). Acute GVHD was seen in 3 patients, one patient had grade IV gut GVHD; another patient had grade III gut GVHD while third patient had grade II skin GVHD. Median hospital stay was 29 days. Six patients were well and transfusion independent 3 to 36 months post transplant. One episode of primary graft failure required a second dose of bone marrow harvest. Another episode of graft rejection received two doses of donor lymphocytes infusion. There were 4 deaths due to grade IV gut GVHD because of uncontrolled systemic Candida infection and one due to hepatic veno-occlusive (VOD) disease. Conclusion: Allogeneic peripheral blood stem cell transplantation can be safely and economically carried out in Pakistan. Although there had been 4 deaths during 36 months follow-up, with increasing understanding and experience the outcome is expected to improve. (author)

2003-04-01

115

A new valid formula in differentiating iron deficiency Anemia from beta-thalassemia trait  

International Nuclear Information System (INIS)

Objective: To compare the validity of a new index (Hb X RDW X 100/ (RBC)/sup 2/ X MCHC) with twelve discriminating functions (DFs) to differentiate iron deficiency anemia (IDA) and beta-thalassemia trait (beta-TT). Methodology: A total of 823 patients (317 IDA and 506 beta-TT) aged 15 to 35 year old were enrolled in this study. The diagnostic sensitivity, specificity and other validity parameters were calculated to assess the diagnostic reliability of the novel index [Keikhaei index (KI)] vis-a-vis the other published DFs [Mentzer Index (MI), Green and King Index (G and KI), red cell distribution width index (RDWI), England and Fraser Index (E and FI), Bessman and Feinstein index (B and FI), Telmissani et al index (TI), Srivastava and Bevington index (S and BI), Shine and Lal index (S and LI), Ricerca et al index (RI), Ehsani et al index (EI), Sirdah et al index (SI), and Red Blood Cell Count(RBC)] were calculated in all patients. Results: All thirteen DFs did not have the sensitivity and specificity of 100%. The KI, RDWI, Gand KI and E and FI showed the most sensitivity and specificity for both IDA and TT; moreover, the lowest reliable indices belonged to B and FI, SandLI and RI. Conclusion: According to Youden's index (YI), DFs in the order of highest to lowest were KI > G and KI > RDWI > E and FI > RBC> M I> EI > TI > SI > S and BI > RI> SandLI >B and FI. (author)

2010-01-01

116

Frequency of Beta-globin gene mutations in beta-thalassemia patients from east of Mazandaran  

Directory of Open Access Journals (Sweden)

Full Text Available (Received 6 Aug, 2008; Accepted 3 Dec, 2008 Abstract Background and purpose: Beta-thalassemia is the most common inherited disorder in the world, especially in Iran. According to Iranian thalassemia society registry, 18616 thalassemia patients now living in Iran, which Mazandaran and Fars provinces have the most patients. Previous reports have shown that the frequency of b-thalassemia carriers is more than 10% in Mazandaran province. Although b-thalassemia is very heterogenous in the molecular level, but in each population, 5 to 10 mutations are more common. In this research common mutation in eastern area of Mazadaran province was investigated. Materials and methods: 5 to 10 ml peripheral blood samples were collected from volunteer patients who were referred to Boali Sina Hospital in Sari. DNA was extracted from blood, then 20 different mutations were screened and detected using two different methods, ARMS-PCR and Reverse-Dot Blot in Thalassemia Research Center in Sari and Amir Kola Thalassemia Center. Results: From 240 chromosomes investigated in 120 b-thalassemia patients in total, 96.25% mutations were identified. 13 different mutations were identified from 231 chromosomes. Among different mutations investigated, IVSII-1G>A was detected as the most common with frequency of 68/3%, which was homozygous in 64 individuals (53/3% and compound heterozygous with other mutations in 34 individuals (28/3% respectively. Mutations C8(-AA, codon22(G>A/ FSC 22/23/24(-7bp, codon 30(G>A, and IVSII-1G>A were identified in 83% of chromosomes which were studied (200 chromosomes from 240. Conclusion: Mutation IVSII-1G>A is the most common mutation in northern provinces (Gilan, mazandaran, Golestan in recent study. Also, comparison of these results with the similar finding from other provinces showed that the distributions of mutations in the northern area are different with northwest, south or southeast of the country.

Mohammad Bagher Hashemi Soteh

2008-01-01

117

Comparison of red cell distribution width and a red cell discriminant function incorporating volume dispersion for distinguishing iron deficiency from beta thalassemia trait in patients with microcytosis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The red cell distribution width (RDW), and another red cell discriminant function incorporating RDW (MCV² x RDW/Hgb x 100) were determined in a group of 30 patients with iron deficiency anemia, 30 patients with beta thalassemia trait, and 30 normal subjects. Both RDW and (MCV² x RDW/Hgb x 100) mean values were significantly higher in iron deficiency anemia than in beta thalassemia trait (p<0.001). Taking RDW equal or above 21.0 percent among microcytic anemia patients, we identified correct...

Carmen Silvia Passos Lima; Aparecida Ribeiro de Carvalho Reis; Helena Zerlotti Wolf Grotto; Sara Teresinha Ollala Saad; Fernando Ferreira Costa

1996-01-01

118

Takayasu's arteritis presenting with temporary loss of vision in a 23-year-old woman with beta thalassemia trait: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Introduction The simultaneous presence of Takayasu's arteritis and beta thalassemia trait is a rare combination. To the best of our knowledge, this is the first case report on Takayasu's arteritis and beta thalassemia presenting together. Case presentation This is a case report of a 23-year-old Asian woman of Pakistani descent who presented with a headache, blurred vision and dizziness. Conclusion The correct diagnosis of our patient was based on clinical suspicion, appropriate imaging studies, and deliberation of the differential diagnosis. The management of our patient depended on the correct diagnosis of both the diseases.

Shabbir Fahad A

2011-09-01

119

Sequence-specific modification of a beta-thalassemia locus by small DNA fragments in human erythroid progenitor cells.  

Science.gov (United States)

Gene therapy has been proposed as a definitive cure of beta-thalassemia. We applied a gene targeting approach, based on the introduction of small DNA fragments (SDF) into erythroid progenitor cells, to specifically modify the beta-globin gene sequence at codon 39. The strategy was first tested in normal individuals by delivering mutant SDF that were able to produce the beta-39 (C->T) mutation. Secondly, wild-type SDF were electroporated into target cells of beta-3i9/beta-39 b-thalassemic patients to correct the endogenous mutation. In both cases, gene modification was assayed by allele-specific polymerase chain reaction of DNA and mRNA, by restriction fragment length polymorphism analysis and by direct sequencing. PMID:17229648

Colosimo, Alessia; Guida, Valentina; Antonucci, Ivana; Bonfini, Tiziana; Stuppia, Liborio; Dallapiccola, Bruno

2007-01-01

120

Perfil de beta talassemia heterozigota obtido a partir de análise data mining em banco de dados / The profile of beta thalassemia obtained by data mining analysis in a database  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese [...] Abstract in english Variations in the phenotypic expression of heterozygous beta thalassemia reflect the formation of different populations. To better understand the profile of heterozygous beta-thalassemia of the Brazilian population, we aimed at establishing parameters to direct the diagnosis of carriers and calculat [...] e the frequency from information stored in an electronic database. Using a Data Mining tool, we evaluated information on 10,960 blood samples deposited in a relational database. Over the years, improved diagnostic technology has facilitated the elucidation of suspected beta thalassemia heterozygote cases with an average frequency of 3.5% of referred cases. We also found that the Brazilian beta thalassemia trait has classic increases of Hb A2 and Hb F (60%), mainly caused by mutations in beta zero thalassemia, especially in the southeast of the country.

Ana L. B., Domingos; Lucas A., Granzotto; Edis, Belini Junior; Thiago Y. K., Oliveira; Ana C. B., Domingos; Claudia R., Bonini-Domingos.

 
 
 
 
121

Twenty-year outcome analysis of genetic screening programs for Tay-Sachs and beta-thalassemia disease carriers in high schools.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Programs for education, screening, and counseling of senior-high-school students, in populations at high risk for Tay-Sachs and beta-thalassemia diseases, have existed for >20 years in Montreal. Four process and outcome variables are reported here: (i) voluntary participation rates in the high-school cohort; (ii) uptake rates for the screening test; (iii) origin of carrier couples seeking the prenatal diagnosis option in the programs; and (iv) change in incidence of the two diseases. Between ...

1996-01-01

122

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Deferasirox (ICL670) is a once-daily oral iron chelator developed for the treatment of chronic iron overload from blood transfusions. A comparative phase 3 trial was conducted to demonstrate the efficacy of deferasirox in regularly transfused patients with beta-thalassemia aged 2 years or older. Patients were randomized and received treatment with deferasirox (n = 296) or deferoxamine (n = 290), with dosing of each according to baseline liver iron concentration (LIC). The primary endpoint was...

Piga, Antonio Giulio

2006-01-01

123

Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background: The prevalence of microcytosis in donors and Iron Deficiency Anemia (IDA) and Beta-Thalassemia trait (BTT) in microcytic and non-microcytic donors has not been studied in India. The present study aims at finding the same. Materials and Methods: Initially 925 donor samples were evaluated on cell-counter. Of these, 50 were found to be microcytic. These were subjected to Ferritin and HbA2 determination. Subsequently, an additional 51, age-and-sex matched non-microcyt...

2009-01-01

124

Molecular genetic testing of beta-thalassemia patients of Indian origin and a novel 8-bp deletion mutation at codons 36/37/38/39.  

Science.gov (United States)

Hemoglobinopathies are the most commonly inherited genetic disorders in India. Certain communities in India have a high predisposition to beta-thalassemia. To offer prenatal diagnosis and to prevent the birth of an affected child, mutation testing in clinically diagnosed beta-thalassemia patients/carriers is a prerequisite. Over a period of 4 years, we have conducted DNA analysis in 385 carriers for 15 beta-thalassemia mutations, HbD, HbE, and HbS. Using reverse dot blot (RDB) and amplification refractory mutation system (ARMS), we have been able to identify mutations in 381 of 385 thalassemia chromosomes. The study included the analysis of five common mutations found in Asian Indians, namely IVS1-5 (G-C), 619-bp deletion, IVS1-1 (G-T), and the frameshifts at CD8/9(+G) and CD41/42(-CTTT). The occurrence of these five mutations was seen in 299 (91.2%) carriers referred to us, the percentage of mutations varying between 4.0 and 68.9%. We also found Cd16 (-C) in 2.1%, CD30 (G-C) in 1.5%, and CD 15(G-A) in 0.6%; these are considered common mutations in the Indian population, as well. The beta-thalassemia anomaly in 4 (0.6%) carriers remained uncharacterized by RDB and ARMS analysis. During delineation of the mutations in uncharacterized carriers by single-stranded conformational polymorphism (SSCP) and sequencing analysis, we have also been able to identify two unusual mutations, one involving an initiation codon and the second involving a novel 8-bp deletion, in Indian families of Uttar Pradesh origin. PMID:12885342

Gupta, Anju; Hattori, Yukio; Gupta, Usha R; Sarwai, Swati; Nigam, Nitu; Singhal, Pragya; Agarwal, Sarita

2003-01-01

125

Associations of red blood corpuscle mean volume and hematocrit with severity of beta-globin gene mutations in beta-thalassemia carriers  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Aim: Thalassemia, a heterogeneous disease, is one of the most common single-gene diseases worldwide. The aim of this study was to find associations between hematological indices and severity of beta-globin gene mutations in beta-thalassemia carriers. Materials and Methods: In this cross-sectional study, 30 beta-goblin gene mutations (b+ and b? in 1206 unrelated beta-thalassemia carriers were investigated. In addition, their hematological indices, including CBC and electrophoresis results, were determined.  The association between genetic findings and hematological parameters (mean corpuscular volume (MCV and mean hematocrit corpuscular hematocrit (MCH were determined using the SPSS software, the statistical test being the t-test.  Results: The results indicated that b+-thalassemia carriers had higher MCV and MCH means than b?-thalassemia carriers. These findings would certainly have practical implications in public health. Conclusion: The results show a significant correlation between two hematological indices and certain types of mutations in beta-thalassemia carriers.

M A Ehsani

2011-04-01

126

The influence of the BCL11A polymorphism on the phenotype of patients with beta thalassemia could be affected by the beta globin locus control region and/or the Xmn1-HBG2 genotypic background.  

Science.gov (United States)

To study the influence of the ? globin locus control region (LCR) genotypic background on the phenotype modifying role of BCL11A polymorphisms, 100 cases of thalassemia, 48 homozygous for the A allele and 52 homozygous for the G allele at the 5'HS4-LCR palindromic polymorphic site were genotyped for two BCL11A single nucleotide polymorphisms (rs11886868 and rs766432) in the intronic region of this gene. The effect of these polymorphisms on HbF variation was also examined in 122 normal individuals. The 5'HS4-LCR had the most significant role in determining the phenotype of these thalassemia patients. BCL11A polymorphisms showed a significant role in determining the phenotype of patients homozygous for the G allele at 5'HS4-LCR. However, the majority of patients homozygous for the A allele at 5'HS4-LCR, showed a severe phenotype, regardless of the BCL11A genotype. These results, without undermining the strength of BCL11A as a silencer of the ? globin gene, suggest that the LCR background, by governing the state of BCL11A binding to this region, plays a more significant role in determining the thalassemia phenotype than the level of BCL11A protein expression, that might be influenced by single nucleotide polymorphisms in intronic regions of the BCL11A gene. Functional studies to confirm the interactions between BCL11A and LCR could be useful in designing pharmacogenetic strategies for the treatment of beta thalassemia major. PMID:23541515

Neishabury, Maryam; Zamani, Fahimeh; Keyhani, Elahe; Azarkeivan, Azita; Abedini, Seyedeh Sedigheh; Eslami, Masumeh Sadat; Kakroodi, Setareh Talebi; Vesiehsari, Mahjoobeh Jafari; Najmabadi, Hossein

2013-08-01

127

Twenty-year outcome analysis of genetic screening programs for Tay-Sachs and beta-thalassemia disease carriers in high schools.  

Science.gov (United States)

Programs for education, screening, and counseling of senior-high-school students, in populations at high risk for Tay-Sachs and beta-thalassemia diseases, have existed for >20 years in Montreal. Four process and outcome variables are reported here: (i) voluntary participation rates in the high-school cohort; (ii) uptake rates for the screening test; (iii) origin of carrier couples seeking the prenatal diagnosis option in the programs; and (iv) change in incidence of the two diseases. Between 1972 and 1992, we screened 14,844 Ashkenazi-Jewish students, identified 521 HexA-deficient carriers (frequency 1:28), reached 89% of the demographic cohort in the educational component of the program, and achieved 67% voluntary participation in the subsequent screening phase. The corresponding data for the beta-thalassemia program are 25,274 students (mainly of Mediterranean origin) representing 67% of the cohort with 61% voluntary participation in the screening phase (693 carriers; frequency 1:36). From demographic data, we deduce that virtually all the carriers identified in the high-school screening program remembered their status, had their partner tested if they did not already know they were a carrier couple, and took up the options for reproductive counseling/prenatal diagnosis. In Montreal, the current origin of all couples using prenatal diagnosis for Tay-Sachs and beta-thalassemia diseases is the corresponding genetic screening/testing program, whereas, at the beginning of the programs, it was always because there was a history of an affected person in the family. Incidence of the two diseases has fallen by 90%-95% over 20 years; the rare new cases are born (with two exceptions) outside the target communities or to nonscreened couples. PMID:8808593

Mitchell, J J; Capua, A; Clow, C; Scriver, C R

1996-10-01

128

Combinations of beta chain abnormal hemoglobins with each other or with beta-thalassemia determinants with known mutations: influence on phenotype.  

Science.gov (United States)

Hematological and hemoglobin (Hb) data are presented for numerous patients with compound heterozygosities for different beta chain variants and for a beta chain variant with different beta-thalassemia (beta-thal) alleles. Considerable variations, which result from the type of beta chain variant and beta-thal mutation, can be noted. The comparison again emphasizes the importance of determining the diagnoses at the molecular level to aid the physician in the management of patients with different combinations of abnormalities. Simplification and commercialization of modern technology may make the introduction of this approach in some clinical chemistry laboratories possible. PMID:9342003

Huisman, T H

1997-10-01

129

Beta Thalassemia (For Parents)  

Science.gov (United States)

... thalassemia, he or she will take a blood sample for testing. Blood tests can reveal red blood cells that are pale, varied in shape and size, or smaller than normal. They also can detect low red blood cell counts and cells with an ...

130

High-throughput beta-thalassemia carrier screening by allele-specific Q-primer real-time polymerase chain reaction.  

Science.gov (United States)

Based on a novel Q-primer real-time polymerase chain reaction (PCR) system, we designed allele-specific Q-primers for the detection of three beta-thalassemia mutations [Cd41/42(-TCTT), IVSI nt5 (G>C), and IVSII nt654 (C>T)] that have a high carrier frequency in Southeast Asia. With clear distinction between heterozygote and wild-type, DeltaC(t) (threshold cycle) values were defined. The results of evaluating 139 blinded samples by our system match perfectly with those obtained by the conventional reverse dot blot (RDB) method. With a 384-well plate that included replicates in the same analysis, our throughput reached 190 reactions per run with a turnaround time as short as 130 min, and the cost of consumables was as low as $1 (US) for each test. PMID:20433808

Liu, Xiaokun; Law, Hai Yang; Tan, Yuen Ming; Hong, Yan

2010-09-01

131

beta-thalassaemia major hos børn og unge i Danmark  

DEFF Research Database (Denmark)

INTRODUCTION: Beta-thalassemia major occurs with increasing frequency among Danish children as a result of immigration. The aim of the study was to estimate the occurrence of beta-thalassemia major in Denmark, analyse the treatment and organ functions, and identify areas for an improved treatment strategy. MATERIAL AND METHODS: During 1998-99 all Danish pediatric departments were contacted for identification of children aged 0-18 years with beta-thalassemia major. Blood transfusions and chelation therapy were registered, and for Eastern Denmark clinical, endocrine, cardiac, and serologic parameters were performed. RESULTS: Twenty-six children had beta-thalassemia major. Out of these, 20 received blood transfusions, and 17 patients were chelated. Eight patients were not chelated owing to previous bone marrow transplantation, treatment with hydroxyurea or ferritin < 2000 micrograms/l and young age. One patient had died. The body height was between 1.5 and -5.4 SDS (median -1.7) and the sitting height was -0.6to -5.6 SDS (median -2.3). The bone age was delayed 1-5 years (median -2.5) in six out of ten examined patients, and puberty delayed in four out of five. A dilated left ventricle was documented in one out of eight patients examined. All patients were HIV and hepatitis C negative. For 75% of the children, the parents were related. DISCUSSION: Children and adolescents with beta-thalassemia major in Denmark experience major heterogenicity with regard to treatment and late effects. An earlier and more effective iron chelation therapy together with improved patient support may reduce growth disturbances and endocrine and cardiac late effects.

Jung, Anne; Main, Katharina Maria

2002-01-01

132

Total Antioxidant Status in Patients with Major ?-Thalassemia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective:Beta-thalassemia major is an autosomal recessive disease causing severe and hemolytic anemia, which begins about 2-6 months after birth. Iron overload, which arises from recurrent transfusion and ineffective erythropoiesis, can enhance oxidative stress in thalassemic patients. The aim of this study was to evaluate the serum total antioxidant capacity of patients with ß-Thalassemia major. Methods:Sixty six Iranian patients with ?-thalassemia major and 66 age-gender matched...

Fatemeh Bazvand; Sedigheh Shams; Mahtab Borji Esfahani; Lili Koochakzadeh; Maryam Monajemzadeh; Mohammad-Taghi Haghi Ashtiani; Nima Rezaei

2011-01-01

133

Egyptian gas for sale  

International Nuclear Information System (INIS)

Israel, Jordan, Palestine, the Lebanon, Turkey and Italy all have at least one factor in common: they're potential customers for Egyptian gas. Once under-used, this major resource is now set to become a valuable export commodity by the turn of the century. (author)

1995-07-01

134

Laboratory assessment of iron status and reticulocyte parameters in differential diagnosis of iron deficiency anemia and heterozygous beta-thalassemia Avaliação laboratorial do estado do ferro e parâmetros reticulocitários no diagnóstico diferencial da anemia ferropriva e beta-talassemia heterozigótica  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Introduction:The soluble form of transferrin receptor (sTfR) has been pointed as a useful parameter to assess the iron status and erythropoiesis activity. Immature reticulocytes present high concentration of membrane transferrin receptor. We tested the correlation between sTfR and reticulocyte parameters in iron deficiency anemia (IDA) and heterozygous beta-thalassemia (hetero beta-thal) patients. Laboratory parameters related to iron status and reticulocytes were studied in order to establis...

Lima, Gise?lia A. F. M.; Grotto, Helena Z. W.

2002-01-01

135

Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening  

Directory of Open Access Journals (Sweden)

Full Text Available Background: The prevalence of microcytosis in donors and Iron Deficiency Anemia (IDA and Beta-Thalassemia trait (BTT in microcytic and non-microcytic donors has not been studied in India. The present study aims at finding the same. Materials and Methods: Initially 925 donor samples were evaluated on cell-counter. Of these, 50 were found to be microcytic. These were subjected to Ferritin and HbA2 determination. Subsequently, an additional 51, age-and-sex matched non-microcytic donor samples were selected to serve as controls. These were subjected to the same tests. Results: The prevalence of microcytosis was 5.4% (50/925. Among the microcytic donors, 52% were IDA, 36% BTT, 8% both, and 4% none. In case of non-microcytic donors 29.4% were IDA, 3.9% BTT, and 66.7% none. Conclusions: The study revealed a high prevalence of IDA and BTT in blood donors and a higher probability of finding these in the microcytic samples. This prompted authors to suggest an algorithm for screening of blood donors for IDA and BTT. The algorithm recommends doing an hemogram on all donor samples, routinely. Ferritin could be done only in microcytic samples. At levels lower than15 ng/ml, it is diagnosed as IDA, and therefore, HPLC is performed only for non-IDA samples with Ferritin levels higher than 15 ng/ml. By employing this algorithm, a substantial number of IDA and BTT could be diagnosed while keeping the number of Ferritin tests small and the number of HPLC tests even smaller and thus making it cost efficient.

Tiwari Aseem

2009-01-01

136

Hematologic phenotype of the mutations IVS1-n6 (T-->C), IVS1-n110 (G-->A), and CD39 (C-->T) in carriers of beta-thalassemia in Greece.  

Science.gov (United States)

The hematologic phenotype was characterized in heterozygotes for three of the most common beta-thalassemia mutations in the Greek population. The study included 17 carriers of beta++ IVS1-n6 (T-->C), 21 carriers of beta+ IVS1-n110 (G-->A), and 17 carriers of beta 0 CD39 (C-->T). The 55 beta-thalassemia heterozygotes were selected from among parents of patients on regular transfusion regimens, and the beta-thalassemia mutation was identified by means of the polymerase chain reaction to amplify the appropriate region of the beta-globin gene and then by allele-specific oligonucleotide hybridization. The assessment of hematologic phenotype included complete blood count and quantitation of hemoglobin HbA2 and HbF and of the globin chain biosynthesis ratio. Comparison and statistical analysis of the hematologic parameters for the three mutations demonstrated no consistent correlation among the three mutations relative to Hb levels, hematocrit, and red cell indices, although heterozygotes for the IVS1-n6 mutation produce red blood cells with slightly higher mean corpuscular volume; significantly lower values of HbA2 (mean, 3.81% +/- 0.62% with four values less than 3.60%) in IVS1-n6 heterozygotes compared with IVS1-n110 heterozygotes (mean, 4.69% +/- 0.48%) and CD39 heterozygotes (mean, 4.75% +/- 0.50%, P n110 heterozygotes (mean, 1.17% +/- 0.75%, P < 0.01). With respect to the HbA2 levels, the findings are in agreement with previous studies in Mediterranean populations; the slightly higher levels of HbF in CD39 heterozygotes appear to be reported for the first time. PMID:7530030

Stefanis, L; Kanavakis, E; Traeger-Synodinos, J; Tzetis, M; Metaxotou-Mavromati, A; Kattamis, C

1994-01-01

137

Identification of IVS-I (-1) (G > C) or Hb Monroe as a report on the beta-globin gene with a beta-thalassemia minor phenotype in south of Iran.  

Science.gov (United States)

We described the first report of IVS-I (-1), codon 30 (G > C) or Hb Monroe in five individuals from four unrelated families in Khuzestan Province. Polymerase chain reaction (PCR) followed by sequencing of the beta-globin gene confirmed the presence of Hb Monroe in the heterozygous form which causes beta-thalassemia due to missplicing in the course of mRNA processing. This mutation has been described in individuals originated from Arabic and Behbahani origins, Ahvaz City, south of Iran. The knowledge of the beta-globin variants present in the Iranian population is essential for the molecular diagnosis and prevention of hemoglobinopathies. PMID:23981164

Hamid, Mohammad; Shariati, Gholamreza; Saberi, Alihossein; Kaikhaei, Bijan; Galehdari, Hamid; Mohammadi-Anaei, Marziye

2013-09-01

138

The pancreas in ?-thalassemia major: MR imaging features and correlation with iron stores and glucose disturbunces  

International Nuclear Information System (INIS)

The study aims at describing the MR features of pancreas in beta-thalassemia major, investigating the relations between MR findings and glucose disturbances and between hepatic and pancreatic siderosis. Signal intensity ratios of the pancreas and liver to right paraspinous muscle (P/M, L/M) were retrospectively assessed on abdominal MR imaging studies of 31 transfusion-dependent patients with beta-thalassemia major undergoing quantification of hepatic siderosis and 10 healthy controls, using T1- (120/4/90), intermediate in and out of phase - (120/2.7, 4/20), and T2*-(120/15/20) weighted GRE sequences. Using the signal drop of the liver and pancreas on opposed phase images, we recorded serum ferritin and results of oral glucose tolerance test (OGTT). Decreased L/M and P/M on at least the T2* sequence were noticed in 31/31 and 30/31 patients, respectively, but no correlation between P/M and L/M was found. Patients with pathologic OGTT displayed a higher degree of hepatic siderosis (p < 0.04) and signal drop of pancreas on opposed phase imaging (p < 0.025), implying fatty replacement of pancreas. P/M was neither correlated with glucose disturbances nor serum ferritin. Iron deposition in the pancreas cannot be predicted by the degree of hepatic siderosis in beta-thalassemia major. Fatty replacement of the pancreas is common and may be associated with glucose disturbances. (orig.)

2007-06-01

139

Percutaneous excretion of iron and ferritin (through Al-hijamah) as a novel treatment for iron overload in beta-thalassemia major, hemochromatosis and sideroblastic anemia.  

Science.gov (United States)

Iron overload is a big challenge when treating thalassemia (TM), hemochromatosis and sideroblastic anemia. It persists even after cure of TM with bone marrow transplantation. Iron overload results from increased iron absorption and repeated blood transfusions causing increased iron in plasma and interstitial fluids. Iron deposition in tissues e.g. heart, liver, endocrine glands and others leads to tissue damage and organ dysfunction. Iron chelation therapy and phlebotomy for iron overload have treatment difficulties, side effects and contraindications. As mean iron level in skin of TM patients increases by more than 200%, percutaneous iron excretion may be beneficial. Wet cupping therapy (WCT) is a simple, safe and economic treatment. WCT is a familiar treatment modality in some European countries and in Chinese hospitals in treating different diseases. WCT was reported to clear both blood plasma and interstitial spaces from causative pathological substances (CPS). Standard WCT method is Al-hijamah (cupping, puncturing and cupping, CPC) method of WCT that was reported to clear blood and interstitial fluids better than the traditional WCT (puncturing and cupping method, PC method of WCT). In other word, traditional WCT may be described as scarification and suction method (double S technique), while Al-hijamah may be described as suction, scarification and suction method (triple S technique). Al-hijamah is a more comprehensive treatment modality that includes all steps and therapeutic benefits of traditional dry cupping therapy and WCT altogether according to the evidence-based Taibah mechanism (Taibah theory). During the first cupping step of Al-hijamah, a fluid mixture is collected inside skin uplifting due to the effect of negative pressure inside sucking cups. This fluid mixture contains collected interstitial fluids with CPS (iron, ferritin and hemolyzed RBCs in thalassemia), filtered fluids (from blood capillaries) with iron and hemolyzed blood cells (hemolyzed RBCs, WBCs and platelets). That fluid mixture does not contain intact blood cells (having diameters in microns) that are too big to pass through pores of skin capillaries (6-12nm in diameter) and cannot be filtered. Puncturing skin upliftings and applying second cupping step excrete collected fluids. Skin scarifications (shartat mihjam in Arabic) should be small, superficial (0.1mm in depth), short (1-2mm in length), multiple, evenly distributed and confined to skin upliftings. Sucking pressure inside cups (-150 to -420mmHg) applied to skin is transmitted to around skin capillaries to be added to capillary hydrostatic pressure (-33mmHg at arterial end of capillaries and -13mmHg at venous end of capillaries) against capillary osmotic pressure (+20mmHg). This creates a pressure gradient and a traction force across skin and capillaries and increases filtration at arterial end of capillaries at net pressure of -163 to -433mmHg and at venous end of capillaries at net pressure of -143 to -413mmHg resulting in clearance of blood from CPS (iron, ferritin and hemolyzed blood cells). Net filtration pressure at renal glomeruli is 10mmHg i.e. Al-hijamah exerts a more pressure-dependent filtration than renal glomeruli. Al-hijamah may benefit patients through inducing negative iron balance. Interestingly, Al-hijamah was reported to decrease serum ferritin significantly (by about 22%) in healthy subjects while excessive traditional WCT was reported to cause iron deficiency anemia. Al-hijamah is a highly recommended treatment in prophetic medicine. In conclusion, Al-hijamah may be a promising adjuvant treatment for iron overload in TM, hemochromatosis and sideroblastic anemia. PMID:24857772

El Sayed, Salah Mohamed; Abou-Taleb, Ashraf; Mahmoud, Hany Salah; Baghdadi, Hussam; Maria, Reham A; Ahmed, Nagwa Sayed; Nabo, Manal Mohamed Helmy

2014-08-01

140

On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Trials of iron chelator regimens have increased the treatment options for cardiac siderosis in beta-thalassemia major (TM) patients. Treatment effects with improved left ventricular (LV) ejection fraction (EF) have been observed in patients without overt heart failure, but it is unclear whether these changes are clinically meaningful. Methods This retrospective study of a UK database of TM patients modelled the change in EF between serial sca...

2011-01-01

 
 
 
 
141

Combined Therapy with Deferiprone and Desferrioxamine as Compared to Desferasirox on Ventricular Function in Thalassemia Major Patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

AbstractBackgroundMyocardial iron overload is the leading cause of death in patients with beta-thalassemia major.Combined therapy with deferiprone(DFP) and desferrioxamine (DFO)were suggested to be more effective than deferasirox(DFX) for removing heart iron. Deferasirox has recently been made available but its long-term efficacy on cardiac function has not yet been established. Our study aimed to compare the effectiveness of deferiproneanddesferrioxaminewith deferasiroxon ventricular functio...

2012-01-01

142

"Evaluation Of compliance To Iron Chelation Therapy With Defe-Roxamine In Patients With Major Thalassemia In Iran In 2004 "  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background and Aim: With the introduction of long term subcutaneous administration of Deferoxamine there has been a decline in the morbidity and mortality of transfusion-dependent beta thalassemia patients. But parenteral iron chelation therapy is still a burden and a major reason for unsatisfactory compliance and places an additional psychological burden on the patients. There are some factors contributing to low compliance in these patients. To evaluate compliance to Deferoxamine and barrie...

Izadyar, M.; Jafarieh, L. Sedighipourand H.

2006-01-01

143

Egyptian contraception.  

Science.gov (United States)

Dr. Margaret Jackson recently visited Yugoslavia and Egypt on behalf of the IPPF. She supplies the following notes for the Bulletin on her impressions of the contraceptive programme in Egypt: Dr. Mazhar was appointed about a year ago to organize and coordinate the Government family planning programme in Egypt. Because of the urgency of getting the programme under way, and in order to run the service as economically as possible, Dr Mazhar decided to use the existing health centres. Fortunately these are widely distributed throughout the habitable part of Egypt, concentrated mainly in the most thickly populated areas. Although these centres are not always adequate for use in the programme they are gradually being improved. Of the newer methods, oral contraceptives were the first to be used extensively in Egypt; they are well accepted by many women. IUDs have been successfully fitted by some Egyptian doctors for a number of years (e.g. by the late Dr. M.K.A. Razzak, and more recently by Dr M.I. Ragab), but this method has not been used on a large scale. Now the Government plan to include IUDs in the family planning programme; and Dr Mazhar is determined to keep the fitting of these devices in the hands of the gynaecologists. It has been decreed that all those holding gynaecological qualifications shall spend a given number of hours a week in government service helping with the IUD programme. Whether this will work smoothly is still uncertain, but the idea is fundamentally sound. PMID:12332034

1967-01-01

144

Total Antioxidant Status in Patients with Major ? -Thalassemia  

Directory of Open Access Journals (Sweden)

Full Text Available Objective:Beta-thalassemia major is an autosomal recessive disease causing severe and hemolytic anemia, which begins about 2-6 months after birth. Iron overload, which arises from recurrent transfusion and ineffective erythropoiesis, can enhance oxidative stress in thalassemic patients. The aim of this study wasto evaluate theserum total antioxidant capacity of patients with ß-Thalassemia major.Methods:Sixty six Iranian patients with ?-thalassemia major and 66 age-gender matched controls were evaluated for serum total antioxidant status (TAS, uric acid (UA, bilirubin and albumin. In addition, serum ferritin and transaminases were recorded in these subjects.Findings: Significant increases of TAS, UA, and bilirubin were observed in the patient group, compared with the control group (P< 0.01. Mean TAS and bilirubin in male patients was higher than in females (P=0.005 and P=0.008, respectively. There was also direct correlation between TAS and albumin (P< 0.001, bilirubin (P< 0.001 and UA (P=0.002.Conclusion: Endogenous antioxidants such as ferritin, UA and bilirubin can result in increased level of TAS in the patients with Beta-thalassemia major. Compensatory excess of TAS to oxidative stress could also be the reason for difference between our findings and previous studies.

Fatemeh Bazvand

2011-06-01

145

Total Antioxidant Status in Patients with Major ?-Thalassemia  

Directory of Open Access Journals (Sweden)

Full Text Available Objective:Beta-thalassemia major is an autosomal recessive disease causing severe and hemolytic anemia, which begins about 2-6 months after birth. Iron overload, which arises from recurrent transfusion and ineffective erythropoiesis, can enhance oxidative stress in thalassemic patients. The aim of this study was to evaluate the serum total antioxidant capacity of patients with ß-Thalassemia major. Methods:Sixty six Iranian patients with ?-thalassemia major and 66 age-gender matched controls were evaluated for serum total antioxidant status (TAS, uric acid (UA, bilirubin and albumin. In addition, serum ferritin and transaminases were recorded in these subjects. Findings: Significant increases of TAS, UA, and bilirubin were observed in the patient group, compared with the control group (P<0.01. Mean TAS and bilirubin in male patients was higher than in females (P=0.005 and P=0.008, respectively. There was also direct correlation between TAS and albumin (P<0.001, bilirubin (P<0.001 and UA (P=0.002. Conclusion: Endogenous antioxidants such as ferritin, UA and bilirubin can result in increased level of TAS in the patients with Beta-thalassemia major. Compensatory excess of TAS to oxidative stress could also be the reason for difference between our findings and previous studies.

Lili Koochakzadeh

2011-06-01

146

Ancient Egyptian herbal wines  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Chemical analyses of ancient organics absorbed into pottery jars from the beginning of advanced ancient Egyptian culture, ca. 3150 B.C., and continuing for millennia have revealed that a range of natural products—specifically, herbs and tree resins—were dispensed by grape wine. These findings provide chemical evidence for ancient Egyptian organic medicinal remedies, previously only ambiguously documented in medical papyri dating back to ca. 1850 B.C. They illustrate how humans around the ...

Mcgovern, Patrick E.; Mirzoian, Armen; Hall, Gretchen R.

2009-01-01

147

Multiple transfused thalassemia major: Ocular manifestations in a hospital-based population  

Directory of Open Access Journals (Sweden)

Full Text Available Purpose: To study the ocular manifestations in multiple transfused beta-thalassemia major patients and assess the ocular side-effects of iron chelating agents. Materials and Methods: In this prospective observational study, 45 multiple transfused beta-thalassemia major children between six months and 21 years of age were enrolled and assigned groups according to the treatment regimens suggested. Group A received only blood transfusions, Group B blood transfusions with subcutaneous desferrioxamine, Group C blood transfusions with desferrioxamine and oral deferriprone and Group D blood transfusions with deferriprone. Ocular status at the time of enrolment was documented. Subjects were observed quarterly for one year for changes in ocular status arising due to the disease process and due to iron chelation therapy. Children with hemoglobinopathies other than beta-thalassemia major, congenital ocular anomalies and anemia due to other causes were excluded. Results: Ocular involvement was observed in 58% of patients. Lenticular opacities were the most common ocular finding (44%, followed by decreased visual acuity (33%. An increased occurrence of ocular changes was observed with increase of serum ferritin and serum iron levels as well as with higher number of blood transfusions received. Desferrioxamine seemed to have a protective influence on retinal pigment epithelium (RPE mottling. Occurrence of lenticular opacities and RPE degeneration correlated positively with use of desferrioxamine and deferriprone respectively. Follow-up of patients for one year did not reveal any change in ocular status. Conclusion: Regular ocular examinations can aid in preventing, delaying or ameliorating the ocular complications of thalassemia.

Taneja Rashi

2010-01-01

148

Ancient Egyptian herbal wines  

Science.gov (United States)

Chemical analyses of ancient organics absorbed into pottery jars from the beginning of advanced ancient Egyptian culture, ca. 3150 B.C., and continuing for millennia have revealed that a range of natural products—specifically, herbs and tree resins—were dispensed by grape wine. These findings provide chemical evidence for ancient Egyptian organic medicinal remedies, previously only ambiguously documented in medical papyri dating back to ca. 1850 B.C. They illustrate how humans around the world, probably for millions of years, have exploited their natural environments for effective plant remedies, whose active compounds have recently begun to be isolated by modern analytical techniques.

McGovern, Patrick E.; Mirzoian, Armen; Hall, Gretchen R.

2009-01-01

149

Egyptian Clover (Trifolium alexandrinum L.) Breeding in Egypt: A Review  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Berseem or Egyptian clover is a winter annual legume of major importance to Egyptian agriculture as a principle source of forage and for conserving soil fertility under intensive cropping. In this review, the published work by authors on breeding Egyptian clover (Trifolium alexandrinum L.) for productivity in Egypt has been summarized since 1980. The variability of the genotypes, genotypic and phenotypic correlation, Path coefficient, the breeding strategies, pollination and seed setti...

Bakheit, Bahy R.

2013-01-01

150

An Egyptian surveying instrument  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Recently, the author (A.C. Sparavigna) proposed that an item found in the Kha's tomb and kept at the Egyptian Museum of Torino is a protractor, able to measure angles. Here the author shows that it is suitable for surveying the stair angle of buildings

Sparavigna, Amelia Carolina

2011-01-01

151

Egyptian Sea Cave  

Science.gov (United States)

This brief article describes an archaeological expedition to the Red Sea coast area of Egypt in 2004. Kathryn Bard, an associate professor of archaeology at Boston University, along with her team, discovered the well-preserved cedar timbers of an ancient Egyptian seafaring vessel near the entrance to a large man-made cave. Limestone tablets with…

Journal of College Science Teaching, 2005

2005-01-01

152

Mosaic segmental uniparental isodisomy and progressive clonal selection: a common mechanism of late onset ?-thalassemia major.  

Science.gov (United States)

Genomic DNA of 3 patients, born as healthy carriers and developing a late-onset severe transfusion-dependent beta-thalassemia major was studied by high-density genome wide SNP array analysis. A mosaic loss of heterozygosity for almost the entire 11p was found, not attributable to deletions but involving mosaicism for segmental paternal isodisomy of 11p. Mitotic recombination leading to mosaic segmental uniparental isodisomy on chromosome 11p in multiple tissues has been described as a molecular disease mechanism for a subset of sporadic Beckwith-Wiedemann syndrome cases. A similar mechanism also seems to be involved in causing late-onset disease in carriers of recessive mutations in other genes located in 11p, such as late-onset beta-thalassemia major and sickle cell disease. We suggest that the loss of maternally imprinted IGF-2 and H19 genes may account for the selective advantage of hematopoietic cells containing this segmental paternal isodisomy of 11p carrying the ?-thalassemia mutation. PMID:22983591

Harteveld, Cornelis L; Refaldi, Chiara; Giambona, Antonino; Ruivenkamp, Claudia A L; Hoffer, Mariëtte J V; Pijpe, Jeroen; De Knijff, Peter; Borgna-Pignatti, Caterina; Maggio, Aurelio; Cappellini, Maria D; Giordano, Piero C

2013-05-01

153

Fascinating Egyptian Mummies  

Science.gov (United States)

Turn up those speakers, and listen to the sounds of eerie, blowing winds in the desert and some woeful Egyptian music. This website starts off by using a multimedia approach to lure visitors into the Mus'e de la civilisation's Fascinating Egyptian Mummies online and museum exhibit. The music follows visitors once they choose the link "Head Into The Tomb". A bouncing yellow arrow all but insists visitors choose the link to "Mummification Process Exhibition". Once the arrow is clicked, visitors hear some menacing Egyptian music and are asked if they want to "Play" a game that tests their skill at determining the steps in the mummification process, or they can choose to skip the game to go directly to the exhibition. The information dispensed here includes the observation that the mummification process took 70 days to complete, and information on some famous mummies is given as well. The next game is about determining which organ goes in which Canopic jar. It's not as easy as it sounds. The final game concerns the weighing of the heart, which visitors can choose to undergo only if they dare.

154

Association between serum ferritin level, cardiac and hepatic T2-star MRI in patients with major ?-thalassemia  

Science.gov (United States)

Background Frequent blood transfusion is often associated with iron overload. Proper use of iron chelators to treat iron overload requires an accurate measurement of iron levels. Magnetic resonance T2-star (T2* MRI) can measure iron level in the heart and liver. Our goal was to see whether an association exists between serum ferritin level and T2* MRI in patients with major beta thalassemia. Materials and Methods Sixty patients with a diagnosis of major beta thalassemia were enrolled in the study. They were older than five years old and needed regular transfusion. Cardiac and hepatic T2*MRI and mean serum ferritin levels were measured within 3 months. Results No significant correlation was observed between serum ferritin level and cardiac T2*MRI (p=0.361, r=-0.120).However, a significant correlation was observed between serum ferritin and liver T2*MRI (p=0.021, r=-0.297). Conclusion Our results showed an association between hepatic T2*MRI and serum ferritin level.

Eghbali, A; Taherahmadi, H; Shahbazi, M; Bagheri, B; Ebrahimi, L

2014-01-01

155

Senenmut: An Ancient Egyptian Astronomer  

CERN Multimedia

The celestial phenomenon have always been a source of wonder and interest to people, even as long ago as the ancient Egyptians. While the ancient Egyptians did not know all the things about astronomy that we do now, they had a good understanding of the some celestial phenomenon. The achievements in astronomy of ancient Egyptians are relatively well known, but we know very little about the people who made these achievements. The goal of this paper is to bring some light on the life of Senenmut, the chief architect and astronomer during the reign of Queen Hatshepsut.

Novakovic, Bojan

2008-01-01

156

Marcadores eletrocardiográficos para detecção precoce de doença cardíaca em pacientes com talassemia beta maior Electrocardiographic markers for the early detection of cardiac disease in patients with beta-thalassemia major  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJETIVO: Analisar comparativamente a dispersão da onda P (DOP) em pacientes com talassemia beta maior (?-TM) e indivíduos saudáveis (controles) para a detecção precoce do risco de arritmias. MÉTODOS: Oitenta e uma crianças com ?-TM, com idades entre 4 e 19 anos, e 74 crianças saudáveis (grupo controle) foram submetidas a exame eletrocardiográfico e ecocardiograma transtorácico de rotina para avaliação cardíaca. A DOP foi calculada como a diferença entre as durações...

2010-01-01

157

The Egyptian Adventure  

Science.gov (United States)

This project is an integrated study for 8-9 year olds encompassing reading, geography, history, math, and science. The literature groups are reading the following fictional books: Ms. Frizzle\\'s Adventures Ancient Egypt by Cole and Degen, Tut, Tut by Jon Scieska, A to Z Mystery - Mummy Mystery by Ron Roy, and Jigsaw Jones - The Case of the Missing Mummy by James Preller. Various non-fiction resources are also being used by the students: Eyewitness Books - Secret of the Mummies, Mummies, Tombs, and Treasure by Lila Perl, and Mummies by C. Wilcox. These essential questions were created by third grade students: How did the rule of pharoahs begin? Who were important pharoahs? What are some facts about pyramids? Ancient Egypt (British Museum) Ancient Egypt Egypt What were the religious beliefs of the ancient Egyptians? Ancient Egypt (British Museum) Ancient Egypt Egypt What are some facts about the Nile River? Why the ...

Lai, Ms.

2007-02-08

158

What Causes Thalassemias?  

Science.gov (United States)

... beta thalassemia trait or beta thalassemia minor. It causes mild anemia. If both genes are altered, you'll have ... Cooley's anemia). The intermedia form of the disorder causes moderate anemia. The major form causes severe anemia. Example of ...

159

The Marskhod Egyptian Drill Project  

Science.gov (United States)

We describe a possible participation of Egypt in a future Mars rover Mission. It was suggested that Egypt participate through involvement in the design, building and testing of a drill to obtain sub-surface samples. The Space Research Institute of the Russian Academy of Sciences (IKI), formally invited the Egyptian Ministry of Scientific Research to study the concept for potential use on the Russian Mars 2001 Mission. As one of the objectives of the Marskhod mission was the analysis of sub-surface samples, a drilling mechanism in the payload would be essential. The Egyptian expertise in drill development is associated with the archaeological exploration of the Pyramids. A sophisticated drilling system perforated limestone to a depth of 2 m without the use of lubricants or cooling fluids that might have contaminated the Pit's environment. This experience could have been applied to a drill development Mars 2001 mission, which was unfortunately canceled due to economic problems.

Shaltout, M. A. M.

160

Transnational NGOs and Egyptian Authoritarianism  

DEFF Research Database (Denmark)

Among the countries of the â??Arab springâ? in the Middle East and North Africa only Egypt claims both a popular revolution and a coup. With a civic revolt in 2011 Egyptians mobilized resources to overthrow an authoritarian ruler. Two years later with a military coup the public fragmented into antagonistic factions: (i) those continuously insisting â??shariyahâ?, the legality of the original revolution of the 25th January 2011; and (ii) proponents of the â??inqilabâ?, the army takeover of July 3rd 2013. This paper explores the role of transnational NGOs (TNGOs)1 in this unresolved political stalemate. With nationwide mass protests in January 2011 Egyptians demanded â??rahilâ?, the departure of Hosni Mubarak, the countryâ??s long term autocratic ruler. Protesters called for â??Eishâ? bread (Life) â??karamaâ? dignity and â??huriyaâ? freedom for all. These euphoric public eruptions marked the culmination of long term entrenched civic engagement. Over the years Egyptian activists established grassroots critical social movements and organizations to directly and indirectly challenge the military regime.

Farah, Abdulkadir Osman

2014-01-01

 
 
 
 
161

The Future of SMEs in Egyptian Economy  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Small and Medium Enterprises (SMEs) in Egypt represent the greatest share of the productive units of the Egyptian economy, the current national policy directions address ways and means of developing the capacities of SMEs. This paper reviews the role of The Developmental Role of SMEs in Egyptian Economy.

2007-01-01

162

Mineralogy, geochemistry and radioactivity of some Egyptian phosphorite deposits  

International Nuclear Information System (INIS)

Mineralogical, geochemical, and radiogeological studies of forty-nine phosphorite samples from three main mining areas in Egypt, Abu Tartur (Western Desert), Sibaiya (Nile Valley), and Safaga (Red Sea) have been carried out. X-ray diffraction studies of these Egyptian phosphorites show that carbonate-fluorapatite (francolite) is the major phosphorite mineral in these deposits, with partial substitution of Mg and Na for Ca, and (CO_3) for (PO_4). Other minerals identified using the x-ray diffraction and scanning electron microscope include calcite, dolomite, pyrite, quartz, gypsum, feldspars, micas and clay (smectite). The uranium content and U/P_2O_5 ratio show low values in Abu Tartur phosphorite deposits relative to the Red Sea and Nile Valley deposits. Autoradiographic studies of the Egyptian phosphorites showed that the radioactivity is unequally distributed among its constituents. The opaque pellets are the most radioactive and the bone fragments are the least radioactive. Geochemically, four distinct groups of minerals were identified in the Egyptian phosphorites according to the degree of correlation between the major apatite components and the trace elements. These mineral groups are apatite, clays, heavy minerals and leached group. The results showed that the phosphorites of Nile Valley are relatively rich in Co and Zn whereas the Red Sea phosphorites are relatively rich in Pb and U. The Western Desert phosphorites are much richer in Ti as compared to the other two areas. Relative to the world phosphorites, the Egyptian phosphorites are geochemically enriched in Co, Mn, and Ni and impoverished in Sr, Cr, U, Zn, Cu, Ti, and V

1981-01-01

163

Study on effectiveness of transfusion program in thalassemia major patients receiving multiple blood transfusions at a transfusion centre in Western India  

Directory of Open Access Journals (Sweden)

Full Text Available Background : Children suffering from beta-thalassemia major require repeated blood transfusions which may be associated with dangers like iron overload and contraction of infections such as HIV, HCV, and HBsAg which ultimately curtail their life span. On the other hand, inadequate transfusions lead to severe anemia and general fatigue and debility. Materials and Methods: Data were obtained from 142 beta-thalassemia major patients aged 3 years or more receiving regular blood transfusions at a transfusion centre in Western India from 1 April 2009 to 30 June 2009. The clinical data and laboratory results were subsequently analyzed. Results: Of the 142 patients, 76 (53.5% were undertransfused (mean Hb <10 gm%. 96 (67% of the patients were taking some form of chelation therapy but out of them only 2 (2% were adequately chelated (S. ferritin <1000 ng/ml. 5 (3.5% of the patients were known diabetics on insulin therapy. 103 (72% of the patients were retarded in terms of growth. The prevalence of transfusion-transmitted infections (TTIs such as HCV, HIV, and HBsAg was respectively 45%, 2%, and 2%, with the prevalence of HCV being significantly more than the general population. The HCV prevalence showed positive correlation with the age of the patients and with the total no of blood transfusions received. As many as 15% (6 out of 40 children who were born on or after 2002 were HCV positive despite the blood they received being subjected to screening for HCV. Conclusions: The study suggests the need to step up the transfusions to achieve hemoglobin goal of 10 gm% (as per the moderate transfusion regimen and also to institute urgent and effective chelation measures with the aim of keeping serum ferritin levels below 1000 ng/ml to avoid the systemic effects of iron overload. In addition, strict monitoring of the children for endocrinopathy and other systemic effects of iron overload should be done. Rigid implementation of quality control measures for the ELISA kits used to detect HCV in donor blood needs to be done urgently. Alternately, more sensitive and specific measures (like NAT testing should be employed for detection of HCV. In the absence of a definitive cure accessible and available to all patients, strict implementation of the above suggested measures will go a long way in improving the quality (and quantity of life in patients of beta-thalassemia major.

Shah Neeraj

2010-01-01

164

Egyptian and foreign cigarettes Pt. 1  

International Nuclear Information System (INIS)

NAA was employed to determine the concentration of 27 elements in an Egyptian cigarette filter before and after smoking. The filter of three foreign cigarette brands were also analyzed and compared to the Egyptian brand. The elements determined are Al, As, Ba, Br, Ce, Cl, Co, Cr, Cs, Eu, Fe, Hf, K, La, Mg, Mn, Na, Ni, Rb, Sb, Sc, Se, Sr, Th, Ti, V and Zn. It was observed that the concentration of the measured elements in the Egyptian brand were within the concentration range of foreign brands, and that the concentration of As, Br, Cl, K, Na and Se in the filters increased after smoking regardless the brands examined. (author)

1985-08-01

165

Effect of hepatic iron concentration and viral factors in chronic hepatitis C-infected patients with thalassemia major, treated with interferon and ribavirin  

Directory of Open Access Journals (Sweden)

Full Text Available Maryam Jafroodi, Ramin Asadi, Abtin Heydarzadeh, Sepiedeh BesharatiDepartment of Hematology, Gulian University of Medical Sciences, Rasht, Guilan, IranBackground: Beta thalassemia major patients are vulnerable to transfusion-transmitted infection, especially hepatitis C virus (HCV, and iron overload. These comorbidities lead to cirrhosis and hepatocellular carcinoma in these patients. In order to prevent these complications, treatment of HCV infection and regular iron chelating seems to be necessary. The aim of this study was to evaluate the effect of hepatic iron concentration (HIC and viral factors on the sustained virological response (SVR in chronic HCV-infected patients, with beta thalassemia major being treated with interferon and ribavirin.Materials and methods: We enrolled 30 patients with thalassemia major and chronic HCV who were referred to the Hematology Clinic of Guilan University of Medical Sciences, between December 2002 and April 2006. HIC was measured by atomic absorption spectroscopy before treatment. The viral factors (viral load, genotype and HIC were compared between those who achieved a SVR and nonresponders.Results: Mean age of the 30 thalassemic patients, was 22.56 ± 4.28 years (14–30 years. Most patients were male (56.7%. Genotype 1a was seen in 24 (80% cases. SVR was achieved in 15 patients (50%. There were no significant correlations between HIC (P = 1.00, viral load (P = 0.414, HCV genotype (P = 0.068, and SVR. No difference was observed in viral load (P = 0.669 and HIC (P = 0.654 between responders and nonresponders.Conclusion: HIC, HCV viral load, and HCV genotype were not correlated with virological response, and it seems that there is no need to postpone antiviral treatment for more vigorous iron chelating therapy.Keywords: hepatitis C virus, hepatic iron concentration, combination therapy, thalassemia major, interferon alfa, ribavirin

Jafroodi M

2011-07-01

166

Biodiesel, the Egyptian experience  

Energy Technology Data Exchange (ETDEWEB)

Biodiesel has recently become more attractive because of its environmental benefits and the fact that it is produced from renewable resources. In recent years, research has been directed to explore plant-based oil and fats as sources for biodiesel fuels. Under Egypt's land and water supply availabilities only non- edible plants such as Jatropha, which can be grown on a large scale on noncropped marginal land and wasteland, can be considered for biodiesel production. Jatropha biodiesel fuel could be an economical alternative blending stock for diesel fuel in Egypt. Cars could be run with Jatropha biodiesel fuel without any change in motor design. The major problem associated with the use of 100 % vegetable biodiesel fuels is caused by the high fuel viscosity, besides their high pour points. (orig.)

Heikal, E.K.; Abdou, I.K. (Egyptian Petroleum Research Inst., Cairo (Egypt)), E-mail: S_a_khali@yahoo.com

2009-07-01

167

Egyptian blue — Cuprorivaite a window to ancient Egyptian technology  

Science.gov (United States)

Egyptian Blue, a multicomponent synthetic blue pigment has been recorded in ancient Egypt since the Fourth Dynasty of the Old Kingdom (2600 2480 B.C.). The pigment consisting of cuprorivaite (CaCuSi4O10) with variable amounts of wollastonite (CaSiO3), Cu-rich glass and cuprite (Cu3O) or tenorite (CuO) was prepared by melting the copper-rich ingredient with lime and desert sand. Low melting temperatures (below 742 °C) were achieved by addition of flux-like plant ashes. The high quality of the pigments collected from monuments of the Fifth Dynasty (2480 2320 B.C.) may indicate that the first manufacture was in early dynastic or perhaps predynastic eras. During the reign of Thutmosis III (18th Dynasty, 1490 1436 B.C.) probably bronze filings were first applied as starting material, thus indicating a technological innovation. This new method was employed till the Roman times.

Jaksch, H.; Seipel, W.; Weiner, K. L.; Goresy, A. El

1983-11-01

168

Salinity Tolerance in Egyptian Spring Wheat Genotypes  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The study on the evaluation of salt tolerance of Egyptian wheat genotypes compared with the standard salt tolerance genotype of wheat Kharchia based on physiological and agronomic traits is not only important for Egyptian farmers to develop different strategies to increase wheat salt tolerance by agricultural practices, but it also suggests that breeders should consider to include the physiological and agronomic traits such as more tillers, high leaf number, great leaf area, low Na+ and Cl- c...

El-hendawy, Salah El-sayed

2005-01-01

169

Distribution of Iodine in Egyptian Marine Algae ????? ????? ?? ??????? ??????? ???????  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Thirty-two species of Egyptian marine algae of Chlorophycophyta, Phaeophycophyta and Rhodophycophyta collected ffroor mth tehire cMoendteitnetr roafn ioedainn e(1. 7 spp.) and R'ed (15 spp.) Seash as beena nalyzed Distribution of iodine in Egyptian marine algae showed noticeable local differences. The highest values were obtained in the species collected from the Mediterranean Sea. Iodine contents of the investigated species exhibited significant differences according to the species and showe...

1995-01-01

170

Radiological assessment of the Egyptian Mediterranean coast  

International Nuclear Information System (INIS)

On the basis of extensive sampling, gamma spectrometry, laboratory analyses, data evaluation and comparison with the reference data, the following assessment has been carried out. The radiological assessment has been done for a wide scale study area (about 1100 km) from El- Salloum in the west of the Mediterranean coast of Egypt to El-Arish in the east. The environmental radiological assessment steps are based on the criteria previously mentioned. The sources of radioactivity possibly reach the Egyptian Mediterranean coast can be summarized as: primordial and radiogenic radionuclides (e.g. 40K, 238U and 232Th series), cosmic rays and cosmogenic radionuclides (e.g. 7Be), fertilizers (e.g. superphosphate), black sand (transported by Nile River), fallout (either from nuclear testing or Chernobyl), seawater currents (transported either natural or man-made), Suez Canal (subject to receive a radioactive releasing and effluents from either nuclear power ships or submarines passes through the canal), biological migration and sedimentary longshore movement (e.g. Anguilla anguilla), atmospheric radioactivity (e.g. 222Rn and its daughters), domestic and medical sewage (minor source, short half-life), depleted uranium dust (possibly), satellite and aircraft accident (accidentally) and rarely loss of industrial radioactive source (incidentally). El-Salloum, Rashid and El-Gamil have been considered as concentrated basins for the majority of the radioisotopes. This suggestion was due to the special topographical features of these three stations, which make the accumulation of the radioactive isotopes possible. Calculations of outdoor absorbed dose rate for human population at all stations under investigation from 238U, 232Th and 40K were carried out. The calculated absorbed dose rate has been distinguished the coast into normal areas and Rashid black sand area as high background area. The range of calculated dose was 8.39-38.5 ?Gy/h. Good agreement was observed with NCRP absorbed dose rates 26 (17-40) nGy/h. Calculations of gamma absorbed dose rate in Rashid black sand area collected in July 1998 recorded as 0.72 ?Gy/h. This value was considered as relatively high dose rate and it is remarkable of the high background radiation area at Rashid. Comparing with the reported gamma radiation dose rates in the others high background radiation areas, it was in agreement with Ramsar in Iran (0.7-50 ?Gy/h) and relatively lower than 1-2 ?Gy/h at Guarapari, Meaipe and Cumuruxatiba in Brazil. Annual intake radiation dose was achieved by estimation of the human intake of radioactivity due to fish consumption considering the Egyptian values. Using the mathematical calculation of annual dose per Bq, the total dose to a person, daily fed with 0.0136 kg fish, in one year was 10.3 ?Sv/y, which is mainly from 40K. Annual intake radiation dose was achieved by estimation of the human intake of radioactivity due to fish consumption considering the Egyptian values. Using the mathematical calculation of annual dose per Bq, the total dose to a person, daily fed with 0.0136 kg fish, in one year was 10.3 ?Sv/y, which is mainly from 40K. The only man-made radionuclide detected in the Egyptian Mediterranean coast is 137Cs with average value 0.37 Bq/kg. This average value shows high agreement with the other referenced values in the world. The main source of 137Cs is atmospheric fallout either from nuclear testing or Chernobyl. The marine transport from western Mediterranean could be considered as another source. Surface seawater salinity showed a positive correlation with the concentrations of 40K in surface seawater (r = 0.64). A mathematical model has been deduced to estimate the range of natural 40K in the surface seawater. Assessment of radioactivity bioaccumulators was made among different biota collected from the Egyptian Mediterranean coast. It revealed that, Patella spp., Anguilla spp. and Mytilus spp. were the best marine organisms for having the capability to accumulate 40K. Also, Patella spp., Ang uilla spp. and the intermediate leave of Posidonia s

2004-10-25

171

Radiological assessment of the Egyptian Mediterranean Coast  

International Nuclear Information System (INIS)

On the basis of extensive sampling, gamma spectrometry, laboratory analyses, data evaluation and comparison with the reference data, the following assessment has been carried out. The radiological assessment has been done for a wide scale study area (about 1100 km) from El-Salloum in the west of the Mediterranean coast of Egypt to El-Arish in the east. The environmental radiological assessment steps are based on the criteria previously mentioned. The sources of radioactivity possibly reach the Egyptian Mediterranean coast can be summarized as: primordial and radiogenic radionuclides (e.g. 40K, 23'8U and 232Th series), cosmic rays and cosmogenic radionuclides (e.g. 7Be), fertilizers (e.g. superphosphate), black sand (transported by the Nile River), fallout (either from nuclear testing or Chernobyl), seawater currents (transported either natural or man-made), Suez Canal (subject to receive a radioactive releasing and effluents from either nuclear power ships or submarines passing through the Canal), biological migration and sedimentary longshore movement (e.g. Anguilla anguilla), atmospheric radioactivity (e.g. 222Rn and its daughters), domestic and medical sewage (minor source, short half-life), depleted uranium dust (possibly), satellite and aircraft accident (accidental) and rarely loss of industrial radioactive source (incidentally). El-Salloum, Rashid and El-Gamil have been considered as concentrated basins for the majority of the radioisotopes. This suggestion was due to the special topographical features of these three stations, which make the accumulation of the radioactive isotopes possible. Calculations of outdoor absorbed dose rate for human population at all stations under investigation from 238U, 232Th and 40K were carried out. The calculated absorbed dose rate has been distinguished the coast into normal areas and Rashid black sand area as high background area. The range of calculated dose was 8.39-38.5 nGy/h. Good agreement was observed with NCRP absorbed dose rates 26 (17-40) nGy/h. Calculations of gamma absorbed dose rate in Rashid black sand area collected in July 1998 recorded as 0.72 ?Gy/h. This value was considered as relatively high dose rate and it is remarkable of the high background radiation area at Rashid. Comparing with the reported gamma radiation dose rates in the others high background radiation areas, it was in agreement with Ramsar in Iran (0.7-50 ?Gy/h) and relatively lower than 1-2 ?Gy/h at Guarapari, Meaipe and Cumuruxatiba in Brazil. Annual intake radiation dose was achieved by estimation of the human intake of radioactivity due to fish consumption considering the Egyptian values. Using the mathematical calculation of annual dose per Bq, the total dose to a person, daily fed with 0.0136 kg fish, in one year was 10.3 ?Sv/y, which is mainly from 40K. The only man-made radionuclide detected in the Egyptian Mediterranean coast is 137Cs with an average value 0.37 Bq/kg. This average value shows high agreement with the other referenced values in the world. The main source of 137Cs is atmospheric fallout either from nuclear testing or Chernobyl. The marine transport from western Mediterranean could be considered as another source. Surface seawater salinity showed a positive correlation with the concentrations of 40K in surface seawater (r = 0.64). A mathematical model has been deduced to estimate the range of natural 40K in surface seawater. Assessment of radioactivity bioaccumulators was made among different biota collected from the Egyptian Mediterranean coast. It revealed that, Patella spp., Anguilla spp. and Mytilus spp were the best marine organisms for the capability to accumulate 40K. Also, Patella spp., Anguilla spp. and the intermediate leaves of Posidonia spp. were found as good accumulators of both 214Pb and 214Bi. Anguilla spp. and Mytilus were found to be good accumulators of 228Ac

2006-02-01

172

Egyptian and foreign cigarettes Pt. 2  

International Nuclear Information System (INIS)

The concentration of 27 elements was measured using neutron activation analysis in a cigarette brand commercially manufactured in Egypt and in three foreign brands available on the Egyptian market. The cigarette components examined were tobacco, wrapping paper and ash. All results are expressed in absolute values per cigarette. The concentration of Al, As, Ba, Br, Cl, Cs, Eu, Fe, Mn, Na, Ni, Rb, Sb, Sc, Sr, Th, Ti and V in the Egyptian cigarette were above the range determined for the foreign brands examined; however, Ce, Co, Cr, Hf, K, La, Mg, Se and Zn were within that range. Except for K, Mn, Ni and Ti, the above conclusions were the same for elements determined in the ash. The wrapping paper used for the Egyptian cigarette contains the lowest quantity of Cl and Mn. (author)

1986-01-01

173

Some endocrinal aspects of pancreas in beta thalassemia  

International Nuclear Information System (INIS)

The study was carried out to evaluate endocrinal aspects of the pancreas in thalassemia children, ages 5 - 10 years maintained under either regular or irregular iron chelation therapy. A matched control on healthy children, was included for comparison. As regards laboratory findings, fasting and post prandial blood sugar was significantly elevated in thalassemia children than the control and serum insulin was significantly lower in the irregular iron chelation group than both in the regular one and in the control group. Most cases of diabetic thalassemia children clinically and biochemically were of irregular iron chelation and with older age. They were frequently higher transfused. There is significant rise of serum ferritin in diabetic group than in diabetic thalassemia children. In conclusion, pancreatic dysfunction can be detected in thalassemia children, but regular iron chelation can reduce its occurrence. 10 tabs

1995-10-01

174

COAGULOPATHY IN BETA-THALASSEMIA: CURRENT UNDERSTANDING AND FUTURE PERSPECTIVES  

Directory of Open Access Journals (Sweden)

Full Text Available

As the life expectancy of ?-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.

Alessia Marcon

2009-06-01

175

NAA of Egyptian iron ore samples  

International Nuclear Information System (INIS)

Iron ore samples of known weights, one from Umm Nar and three from Wadi Kareim of the eastern desert of Egypt were wrapped in known weight envelops of aluminum foils of the type used in cooking. In order to estimate the background contribution of the aluminum foil to the iron sample, an empty aluminum envelope of known weight was added to the collection. A set of pure iron, cobalt, zirconium and tungsten standards, for measuring reactor parameters fanda, in addition to a bare and a cadmium covered thin gold foils, for confirming thermal and epithermal neutron flux measurements, were added to the collection, f is the thermal to epithermal neutron flux ratio, a is the deviation of the power of the reciprocal of the neutron energy E of the epithermal neutron spectrum from the ideal 1/E law. The whole collection were co-irradiated for 32.66 hours in a can 75A00 in the irradiation box 110 at the core periphery of the second Egyptian research reactor ETRR-2 at 16 MW. The thermal and epithermal neutron fluxes were found to be 3.8143 E + 13 and 9.4815 E + 11 neutrons /cm2.s, respectively. The epithermal neutron spectrum was found to be proportional to 1/E0948. The gamma-ray spectrum of each sample was measured several times for periods between 3600 and 5000 sec. during eight weeks post irradiation. Iron was the major element (about 30%) of the ore samples. Traces of scandium, chromium, cobalt, zinc, Lanthanum, cerium, neodymium, samarium, ytterbium, lutetium hafnium, gold and thorium were found in some of the ore samples. FORTRAN computer programs were written for applying the ko standardization method in the elemental analysis. The activation by epithermal neutrons was taken into consideration in addition to that by thermal neutrons. Corrections for the spectrometer dead time as well as the decay during the measurement periods were also performed

2001-02-17

176

Determinants of Egyptian Agricultural Exports: A Gravity Model Approach  

Directory of Open Access Journals (Sweden)

Full Text Available In this paper, a gravity model approach was employed to analyze the main factors influencing Egypt’s agricultural exports to its major trading partners for the period 1994 to 2008. Our findings are that a one percent increase in Egypt’s GDP results in roughly a 5.42 percent increase in Egypt’s agricultural export flows. In contrast, the increase in Egypt’s GDP per capita causes exports to decrease, which is attributed to the fact that an increase in economic growth, besides the increasing population, raises the demand per capita for all normal goods. Hence, domestic growth per se leads to reduced exports. The exchange volatility has a significant positive coefficient, indicating that depreciation in Egyptian Pound against the currencies of its partners stimulates agricultural exports. Transportation costs, proxied by distance, are found to have a negative influence on agricultural exports. These results are important for trade policy formulation to promote Egyptian agricultural exports to the world market.

Xuexi Huo

2010-11-01

177

Islam in Egyptian Education: Grades K-12  

Science.gov (United States)

This article explores the important role that the religion of Islam plays in the education of Egyptian children. The scrutiny under which the Islamic world finds itself in the after-math of September 11, 2001 has resulted in calls for educational reform, not only from the outside world, but also from the Muslim world itself. The author has a…

Neill, Charlotte M.

2006-01-01

178

Clinical anatomy as practiced by ancient Egyptians.  

Science.gov (United States)

Egypt is famously known for its Nile and pyramids, yet not many people know that Egypt made possible the origin of the anatomical sciences. Several ancient papyri guide us through the Egyptians' exploration of the human body and how they applied anatomical knowledge to clinical medicine to the best of their knowledge. It is through records, such as the Edwin Smith, Ebers, and Kahun papyri and other literature detailing the work of the Egyptian embalmers, physicians, and Greek anatomists, that we are able to take a glimpse into the evolution of the anatomical sciences from 3000 B.C. to 250 B.C. It is through the Egyptian embalmer that we were able to learn of some of the first interactions with human organs and their detailed observation. The Egyptian physician's knowledge, being transcribed into the Ebers and Edwin Smith papyri, enabled future physicians to seek reference to common ailments for diagnosing and treating a variety of conditions ranging from head injuries to procedures, such as trans-sphenoidal surgery. In Alexandria, Herophilus, and Erasistratus made substantial contributions to the anatomical sciences by beginning the practice of human dissection. For instance, Herophilus described the anatomy of the heart valves along with Erasistratus who demonstrated how blood was prevented from flowing retrograde under normal conditions. Hence, from various records, we are able to unravel how Egypt paved the road for study of the anatomical sciences. PMID:21509810

Loukas, Marios; Hanna, Michael; Alsaiegh, Nada; Shoja, Mohammadali M; Tubbs, R Shane

2011-05-01

179

Wealth distribution in an ancient Egyptian society  

CERN Multimedia

Modern excavations yielded a distribution of the house areas in the ancient Egyptian city Akhetaten, which was populated for a short period during the 14th century BC. Assuming that the house area is a measure of the wealth of its inhabitants allows us to make a comparison of the wealth distributions in ancient and modern societies.

Abul-Magd, A Y

2002-01-01

180

The impact of vascular risk factors multiplicity on severity of carotid atherosclerosis—A retrospective analysis of 1969 Egyptian subjects  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background and Purpose: Carotid atherosclerosis has been recognized as a major cause of stroke. The cur-rent study aimed to describe the effect of multiplicity rather than the type of vascular risk factors on severity of carotid atherosclerosis among a large sample of Egyptian population. M...

2013-01-01

 
 
 
 
181

Impaired renal tubular function in pediatric patients with ?-thalassemia major  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: ?-thalassemia major due to ineffective erythrocyte life span leads to severe anemiarequiring regular transfusion, which it can lead to major organs damage. Renal damage can beattributed to chronic anemia, iron over load and or defferoxamin toxicity. The object of this study wasto analyze renal tubular and glomerular function in pediatric patients with beta-thalassemia major.Materials and Methods: 39 patients with ? -thalassemia major whose mean ages were 11.8 yr and22 sex and age matched healthy children as control group were studied. Blood rine samplesand uwereobtained for measuring biochemical markers. Urinary N-Acetyl-?.D.glucosaminidase (NAG andurine NAG to creatine ratio (U Cr /NAGratio were measuredResults: No significant differences were found between serum BUN, creatinine, and also creatinineclearance between both groups. Also there were no significant differences in urine osmolality betweenpatients and controls. Urine NAG was significantly higher in thalassemic patients than control group(p< 0.000. There was positive relation between urinary NAG and duration of illness(r = 0314,p<0.01. There was no significant relationship between urinary NAG and serum ferritin. Finally, nosignificant difference was found in GFR of both groups.Conclusion: Our study showed renal tubular function is impaired in in patients with ?-thalassemiamajor as indicated with increased urinary NAG. Further, we have found a positive relationshipbetween urinary NAG and duration of disease. Thus, in spite of normal GFR and other biochemicalmarker such as BUN and creatinine, increased urinary NAG may be as an early marker of renaldisease in patients with ?-thalassemia majo.

Mojgan Mazaheri

2009-02-01

182

Conservation of a Rare Painted Ancient Egyptian Textile Object from the Egyptian Museum in Cairo  

Directory of Open Access Journals (Sweden)

Full Text Available This study describes conservation of a painted ancientEgyptian textile object from the collection of Osiris clothsin the Egyptian Museum in Cairo, Egypt. An evaluation ofthe reactivation consolidation technique to reinforcementof ancient Egyptian painted textiles was performed.Various investigation methods were carried out to identifythe fibres, paints, and other materials, which are part ofthe selected object. The condition of the object was alsoinvestigated. Newly prepared painted linen textile sampleswere artificially deteriorated to be used for evaluation ofthe suggested reactivation consolidation technique. Theaged textile samples were treated with three selectedadhesives in three different concentrations and the sampleswere evaluated. The results show that the tested consolidationtechnique is suitable to reinforce deterioratedlinen textiles. The evaluated consolidation technique issimple, effective and can be applied using simple tools thatare common to many conservation labs.

Yasin Zidan

2008-01-01

183

The entheomycological origin of Egyptian crowns and the esoteric underpinnings of Egyptian religion.  

Science.gov (United States)

In this paper, I theorize that the Egyptian White and Triple Crowns were originally primordia of the entheogenic Psilocybe (Stropharia) cubensis, which an Egyptian tale known as Cheops and the Magicians allegorically explained grew on barley, and that Osiris was the God of spiritual rebirth because he personified this and other entheogenic mushrooms. I go on to theorize that the plant known commonly as the Eye of Horus, which the Egyptians included in cakes and ales designed to spiritually rebirth the living and the dead, was an entheogenic mushroom cap entirely analogous, if not identical, to Soma. Finally, I explain why so many scholars failed to discern these identities and relationships for so long. PMID:16199133

Berlant, Stephen R

2005-11-14

184

The thermoluminescence (TL) of Egyptian Blue  

International Nuclear Information System (INIS)

Egyptian Blue is a synthesized crystalline pictorial pigment with formula CaCuSi4O10. It has been used in Egypt and Mesopotamia from the 3rd millenium B.C. A preliminary experiment on a recently synthesized sample showed that this pigment is thermoluminescent after ? irradiation (90Sr). As the signal intensity grows linearly with the administered dose within the temperature range commonly used in TL dating, we have been looking for this phenomenon from archaeological pigments. It was encountered with two samples found in excavation. From its intensity and stability we concluded that Egyptian Blue can be dated using TL. This first and positive result encouraged us to extend the method to other types of mineral pigments synthesized by early man, and to suggest that it may be used for direct dating of ancient murals. (author)

1988-01-01

185

Bone Densitometric Analysis in Egyptian Hemodialysis Patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

End-stage renal failure (ESRF) is the ultimate consequence of chronic renal failure, and in such cases dialysis is generally required. Almost all dialysed patients have abnormal bone histology and lower values of glomerular filtration rate have been associated with lower bone mineral density (BMD) at all sites. The objective of the present study was to investigate the effect of hemodialysis (HD) on body-composition (BC), specially segmental and total BMD in Egyptian ESRF patients. Forty ESRF ...

Mohamed, Ehab I.; Khalil, Eman S. D.

2008-01-01

186

Egyptian plant species as new ozone indicators  

Energy Technology Data Exchange (ETDEWEB)

Of more than 30 species of plants from Egypt screened for sensitivity to ozone, four were found to be suitable for use as bioindicators. - The aim of this study was to test and select one or more highly sensitive, specific and environmentally successful Egyptian bioindicator plants for ozone (O{sub 3}). For that purpose more than 30 Egyptian species and cultivars were subjected to extensive screening studies under controlled environmental and pollutant exposure conditions to mimic the Egyptian environmental conditions and O{sub 3} levels in urban and rural sites. Four plant species were found to be more sensitive to O{sub 3} than the universally used O{sub 3}-bioindicator, tobacco Bel W3, under the Egyptian environmental conditions used. These plant species, jute (Corchorus olitorius c.v. local), clover (Trifolium alexandrinum L. c.v. Masry), garden rocket (Eruca sativa c.v. local) and alfalfa (Medicago sativa L. c.v. local), ranked in order of decreasing sensitivity, exhibited typical O{sub 3} injury symptoms faster and at lower O{sub 3} concentrations than Bel W3. Three variables were tested in search of a reliable tool for the diagnosis and prediction of O{sub 3} response prior to the appearance of visible foliar symptoms: pigment degradation, stomatal conductance (g{sub s}) and net photosynthetic CO{sub 2} assimilation (P{sub net}). Pigment degradation was found to be unreliable in predicting species sensitivity to O{sub 3}. Evidence supporting stomatal conductance involvement in O{sub 3} tolerance was found only in tolerant species. A good correlation was found between g{sub s}, restriction of O{sub 3} and CO{sub 2} influx into the mesophyll tissues, and P{sub net}. Changes in P{sub net} seemed to depend largely on fluctuations in g{sub s}.

Madkour, S.A.; Laurence, J.A

2002-12-01

187

SURGICAL PROCEDURES DURING ANCIENT EGYPTIAN MUMMIFICATION  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The authors attempted to replicate Egyptian mummification with a human cadaver. In a previous paper, the authors reported their findings on the use of natron in ancient mummification. This paper discusses the surgical procedures used in evisceration during mummificationLos autores intentaron replicar el sistema de momificación egipcia en un cadáver humano actual y en un trabajo anterior, los autores publicaron sus resultados sobre el uso de natron en la momificación antigua. Este infor...

Bob Brier; Wade, Ronald S.

2001-01-01

188

Antibacterial activity of selected Egyptian ethnomedicinal plants  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Aims: Medicinal plants have recently received the attention of the antimicrobial activity of plants and their metabolites due to the challenge of growing incidences of drug-resistant pathogens. The aims of this study were to determine the antibacterial activities of plant extracts used as ethnomedicinal in Egypt. Methodology and Results: Investigations were carried out to assess the antibacterial efficiency of 11 plant extracts used as ethnopharmacological among Egyptian native people against...

2013-01-01

189

Elemental analysis of two Egyptian iron ores and produced industrial iron samples by neutron activation analysis  

International Nuclear Information System (INIS)

Elemental analysis of two iron ores and initial industrial iron production prepared by the Egyptian Iron and Steel Company of Helwan near Cairo were performed by the instrumental neutron activation analysis technique. Five samples of each type were irradiated for 48 h in a thermal neutron flux of 4x1012 n/cm2 s in the first Egyptian research reactor ET-RR-1. Also, the Pneumatic Irradiation Rabbit System (PIRS), attached to the reactor ET-RR-1 in Inshass, was used to measure short-life elements. The ?-ray spectra were obtained with a hyper pure germanium detection system. The concentration percentage values of major, minor and trace elements are presented. Implications of the elemental concentration values obtained are presented

2001-03-01

190

A new look at old bread: ancient Egyptian baking  

Directory of Open Access Journals (Sweden)

Full Text Available Despite abundant archaeological, pictorial and textual evidence of ancient Egyptian life and death, we have little detailed information about the staple diet of most of the population. Now experimental work by a postdoctoral Wellcome Research Fellow in Bioarchaeology at the Institute is revealing how the ancient Egyptians made their daily bread.

Delwen Samuel

1999-11-01

191

A new look at old bread: ancient Egyptian baking  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Despite abundant archaeological, pictorial and textual evidence of ancient Egyptian life and death, we have little detailed information about the staple diet of most of the population. Now experimental work by a postdoctoral Wellcome Research Fellow in Bioarchaeology at the Institute is revealing how the ancient Egyptians made their daily bread.

Delwen Samuel

1999-01-01

192

Infrared absorption spectra of Egyptian Serpentine Rock  

International Nuclear Information System (INIS)

Infrared absorption spectra of natural egyptian serpentine rock were recorded in the frequency range 200-4000 cm-1, and through the temperature range 200-1000 degree C for 2 hours. The chemical bonds within the lattice structure of serpentine are interpenetrated quantitatively. From the intensities and frequencies shift op the characteristic infrared bands spectra, through heat treatment, we can detect the first endothermic reaction due to the loss of hydroxyl bonds up to 700 degree C, and recrystallization for forsterite refractory at 800 degree C, with the characteristics infrared bands at 506-521 cm-1 of Si-O bending vibrations, at 880-888 cm-1 of Si O-Al vibrations, and at 1000-1075 cm-1 of Si-O stretching vibrations. The infrared bands at 350-398 cm-1 (Si-O bend), and 400-448 cm-1 (Si-O-Mg) are sensitive to follow the phase transformation through heat treatment. Where Egyptian serpentine rock of chemical composition Mg_6(Si_4 O_10) (OH_8), or Mg_3(Si_2 O_5)(OH_4) or 3 Mg O.2 Si O_2.2 H_2 O magnesium hydrositicate, trioctahedral 1:1 family layer lattice silicate still with its lattice structure till 700 degree C. endothermic reaction due to the deformation of hydroxyl bonds, and then formation of forsterite of chemical composition 2 Mg O.Si O_2 from 800 degree C, and the infrared absorption spectra of egyptian serpentine detect a minor quantities of A1_2 O_3 and this phase of tine is Antigorite Mg_3(Si_2 O_5)(OH)_4 trioctahedral 1:1 family and high purest related to its standard. Most of the intensities of the characteristics infrared bands spectra are decreased as temperature increases up to 1000 degree C. 2 figs.,2 tabs

1994-03-01

193

German-Egyptian seminar on environmental research  

International Nuclear Information System (INIS)

Industrial development and scientific advancement have opened new frontiers of interest and challenges. Anthropogenic activities are increasingly upsetting the natural environmental balance and are at the same time shifting from local impact to global importance. Science is confronted with the challenge to answer the question of what are the consequences of anthropogenic changes to the environment and to help politics formulate countermeasures for the sake of a sustainable future. Protect results achieved within the Egyptian-German cooperation were presented to the scientific community and to the interested public and discussions on future lines of actions took place. (orig./KW)

1994-03-21

194

Genetic Mutation in Thrombophilic Egyptian Patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Factor V Leiden and the prevalence of PAI-1 promoter 4G/5G polymorphism were examined in 48 Egyptian patients who presented with deep venous thrombosis. They were investigated for the presence of APCR, where positive cases were further subjected to DNA analysis by PCR for detection of factor V Leiden mutation. PAI-1 polymorphism was also studied in patients and 40 healthy individuals matching in age and sex as controls by PCR-RFLP to demonstrate the influence of 4G/5G dimorphism of the PAI-1 ...

Nehal Salah Hasan; Hesham Gamal El Din; Mona Abd El Kader Awad; Hesham Abou Aisha

2006-01-01

195

SURGICAL PROCEDURES DURING ANCIENT EGYPTIAN MUMMIFICATION  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: English Abstract in spanish Los autores intentaron replicar el sistema de momificación egipcia en un cadáver humano actual y en un trabajo anterior, los autores publicaron sus resultados sobre el uso de natron en la momificación antigua. Este informe presenta los procedimientos quirúrgicos utilizados durante el proceso de momi [...] ficación Abstract in english The authors attempted to replicate Egyptian mummification with a human cadaver. In a previous paper, the authors reported their findings on the use of natron in ancient mummification. This paper discusses the surgical procedures used in evisceration during mummification [...

Brier, Bob; Wade, Ronald S..

196

SURGICAL PROCEDURES DURING ANCIENT EGYPTIAN MUMMIFICATION  

Directory of Open Access Journals (Sweden)

Full Text Available The authors attempted to replicate Egyptian mummification with a human cadaver. In a previous paper, the authors reported their findings on the use of natron in ancient mummification. This paper discusses the surgical procedures used in evisceration during mummificationLos autores intentaron replicar el sistema de momificación egipcia en un cadáver humano actual y en un trabajo anterior, los autores publicaron sus resultados sobre el uso de natron en la momificación antigua. Este informe presenta los procedimientos quirúrgicos utilizados durante el proceso de momificación

Bob Brier

2001-01-01

197

The Objectives of the Egyptian Space Programme  

Science.gov (United States)

: The aim of the Egyptsat series is to build on the experience gained from these missions to extend Egypt's space effort into scientific research and to expand its role in educational, agricultural and other development fields. The Egyptian Space Programme envisages that Egypt will be able to join the space age through the gradual establishment of the facilities needed for the manufacture of small research and remote sensing satellites, by acquiring appropriate technological knowledge and capabilities, and by building up the necessary infrastructure to enable the country to design and manufacture its own small satellites. Included in this overall vision would be the capacity to utilize space technologies And applications to serve the national development plans and contribute to the development of scientific and technological research in Egypt, as well as to the establishment of a scientific and research base for advanced industries in Egypt. To hasten the achievement of some or all of these objectives, it will be necessary to: • Transfer advanced space technologies in communication, computers, programs, optics, sensors, new materials, command and control, and energy into the domain of the Egyptian scientific community. • Utilize space technologies and apply these to the country's development plans. • Acquire national capabilities in space technology disciplines. Establish scientific and industrial base in advanced technology fields. • Enhance our human resource capabilities for space sciences fields. • Promote cooperation between the country's research and industrial centres in order to bring about successful project within the national space programme.

Shaltout, Mosalam

198

Antibacterial activity of selected Egyptian ethnomedicinal plants  

Directory of Open Access Journals (Sweden)

Full Text Available Aims: Medicinal plants have recently received the attention of the antimicrobial activity of plants and their metabolites due to the challenge of growing incidences of drug-resistant pathogens. The aims of this study were to determine the antibacterial activities of plant extracts used as ethnomedicinal in Egypt. Methodology and Results: Investigations were carried out to assess the antibacterial efficiency of 11 plant extracts used as ethnopharmacological among Egyptian native people against infectious diseases. Crude methanol, ethanol,chloroform, hexane, acetone and aqueous extract of plants were tested for antibacterial activity in vitro against ten bacterial isolates using the disc diffusion method test. Discs were impregnated with 2 mg/mL of different solvent extracts. Among all the crude extracts, the methanol extract showed the highest activity than other extracts. P. harmala and S. officinalis exhibited highest antibacterial activity against gram positive and negative bacteria while the remainingplants extracts showed less activity. All the plant extracts showed no significant effect against the Bordetella bronchisepta ATCC 4617 except the extracts of M. fragrans and L. sativum. E. coli is the most sensitive microorganism tested, with the lowest MIC value (0.5 mg/mL in the presence of the plant extract of P. harmala and S. officinalis.Conclusion, significance and impact of study: Results obtained herein, may suggest that the ethnomedicinal Egyptian plants possess antimicrobial activity and therefore, they can be used in biotechnological fields as natural preservative ingredients in food and/or pharmaceutical industry.

Mashait, M.

2013-01-01

199

Nutritive Value of Irradiated Egyptian Truffles  

International Nuclear Information System (INIS)

In this study, the nutritive value of truffles was evaluated as protein efficiency ratio (C-PER) compared with casein C-PER. of white truffle was higher than brown truffle and therefore had a better nutritional quality over the brown truffle. Egyptian truffle could be considered as a good source of protein with good essential amino acids content and high nutritive value. It was found that white and brown truffles (Al-Kamah) grow in the north westarn coast of the Egyptian desert, white truffle was identified as Tirmania nivea while brown truffle was identified as Terfezia boudieri. Rats were fed on normal diet as (basal diet) for two weeks, then they were fed on the same diet with 10% of casein (control diet), replaced by 20% of irradiated and non irradiated white and brown truffle dried samples as a protein source. The nutritive value parameters were measured at the end of the experiment, gains in body weight, daily food intake, feed conversion ratio, protein efficiency ratio were measured, biological value, the biological effect on liver kideny function serum glucose. LDL and HDL-cholesterol were investigated too

2005-01-01

200

Physicochemical and radiological studies on some egyptian aquatic areas  

International Nuclear Information System (INIS)

For the purpose of estimating the radiological health and safety to the Egyptian population arises from the natural background involved with coastal areas, it is necessary to make a comprehensive study to investigate the natural radionuclides activities in this environmental ecology. The locations of such areas were chosen from those in which people spend some time (e.g. the Mediterranean and Red Sea beaches, Suez Canal in addition to the River Nile Ismailia Canal and Quaroun Lake). Water and soil samples were brought from these locations and subjected to intensive physical, chemical analysis and radiological investigations. The densities of the collected soil samples were found to fall in the region of clay densities (2.30 - 2.70 g/cm 3 ). The particle size distribution analysis, of these soil samples showed values ranging from 128 ? m to 1303 ? according to sample site. The collected samples are mainly silicates with variable amounts of the major cations; Ca"++, Mg"++, Na"+, K"+ with some other trace elements. For the radiological investigations 238"U, 226"Ra, 232"Th and 40"K activity concentrations were resolved by spectroscopy technique. The majority of samples examined in this work showed variable activities of the naturally occurring radionuclides with fairly low levels compared with literature values reported in other countries. The analysis and discussions of the obtained data are thoroughly performed with the use of equations to estimate the radiation doses

2005-04-01

 
 
 
 
201

Genetic drift evolution under vaccination pressure among H5N1 Egyptian isolates  

Directory of Open Access Journals (Sweden)

Full Text Available Background The highly pathogenic H5N1 is a major avian pathogen that intensively affects the poultry industry in Egypt even in spite of the adoption of vaccination strategy. Antigenic drift is among the strategies the influenza virus uses to escape the immune system that might develop due to the pressure of extensive vaccination. H5N1 mutates in an intensified manner and is considered a potential candidate for the possible next pandemic with all the catastrophic consequences such an eventuality will entail. Methods H5N1 was isolated from the pooled organ samples of four different affected flocks in specific pathogen free embryonated chicken eggs (SPF-ECE. A reverse transcriptase polymerase chain reaction (RT-PCR was performed to the haemagglutingin and neuraminidase. Sequencing of the full length haemagglutingin was performed. Sequence analyses of the isolated strains were performed and compared to all available H5N1 from Egyptian human and avian strains in the flu database. Changes in the different amino acid that may be related to virus virulence, receptor affinity and epitope configuration were assigned and matched with all available Egyptian strains in the flu database. Results One out of the four strains was found to be related to the B2 Egyptian lineage, 2 were related to A1 lineage and the 4th was related to A2 lineage. Comparing data obtained from the current study by other available Egyptian H5N1 sequences remarkably demonstrates that amino acid changes in the immune escape variants are remarkably restricted to a limited number of locations on the HA molecule during antigenic drift. Molecular diversity in the HA gene, in relevance to different epitopes, were not found to follow a regular trend, suggesting abrupt cumulative sequence mutations. However a number of amino acids were found to be subjected to high mutation pressure. Conclusion The current data provides a comprehensive view of HA gene evolution among H5N1 subtype viruses in Egypt. Egyptian H5N1-AIVs are constantly undergoing genetic changes and reveal a complex pattern of drifts. These findings raise the concerns about the value of using influenza vaccines in correlation with the development of antigenic drift in influenza epidemics.

Afifi Manal A

2011-06-01

202

Coronary artery ectasia in Egyptian patients with coronary artery disease.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We conducted a retrospective study of 45 Egyptian patients with coronary artery ectasia who underwent coronary bypass grafting at our institution between 1980 and 1995. We examined the anatomic distribution and type of coronary ectasia and its association with coronary risk factors in these patients, and evaluated the severity of their coronary artery disease. We compared these findings with those from a group of 230 Egyptian patients who did not have coronary ectasia. These patients also und...

Waly, H. M.; Elayda, M. A.; Lee, V. V.; El-said, G.; Reul, G. J.; Hall, R. J.

1997-01-01

203

Egyptian Activism against Female Genital Cutting as Catachrestic Claiming  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This paper deals with questions of the politics of location in knowledge and norm production within the context of Egyptian feminist activism for abandoning female genital cutting practices. It seeks to determine underlying schemes of international campaigning discourse and analyzes how these predicate and complicate Egyptian postcolonial activism. It draws on a broad literature study in addition to fieldwork in Cairo consisting of in-depth interviews with activists and policy makers. My f...

An Van Raemdonck

2013-01-01

204

Characterization of Egyptian coal from Sinai using Moessbauer spectroscopy  

International Nuclear Information System (INIS)

The presence of iron bearing minerals in coal makes the Moessbauer Spectroscopy (MS) extremely useful for characterization of coals from different localities. In this paper the MS has been applied to characterize Egyptian coal from Sinai (Maghara). The chemical analysis of this coal is given. The MS results showed that pyritic sulphur (pyrite and marcasite) is the only bearing mineral in Egyptian coal. A review is given for the iron bearing minerals in coals from different countries measured by MS. (author)

1983-01-01

205

Comparative assessment of deferiprone and deferasirox in thalassemia major patients in the first two decades-single centre experience.  

Science.gov (United States)

Iron overload is mainly responsible for the morbidity and mortality in patients with beta thalassemia major (TM). Our aim was to compare treatment outcomes with oral iron chelators, deferiprone (DFP), and deferasirox (DFX) in the first two decades on therapy. Seventy patients with TM (mean age ± SD, 7.9 ± 4.2; range 1.5-17 years) attending the pediatric day care unit for regular transfusional support were enrolled in this cross-sectional cohort study. The patients were treated either with DFP at the dose of 75-100 mg/kg/d in three divided doses after food or DFX at the dose of 25-40 mg/kg/d as single dose before food. Mean serum ferritin (±SD) was lower in patients below 10 years (n = 44) at 1283 (±600) ng/mL when compared with patients ?10 years (n = 19) at 1546 (±589) ng/mL. There was no significant difference in mean serum ferritin (±SD) level in patients receiving DFP (1360 ± 589) versus DFX (1260 ± 641) in this cohort, P > 0.05. 67% of the patients had Vitamin D deficiency (<50 umol/L). Our results show comparable efficacy of DFP and DFX with regards to iron chelation as estimated by serial serum ferritin levels; however, MRI T2* values were higher in the DFP-treated patients compared to DFX treatment. PMID:23363369

Zachariah, Mathew; Tony, Surekha; Bashir, Wafa; Al Rawas, Abdulhakim; Wali, Yasser; Pathare, Anil

2013-03-01

206

Upgrading the Egyptian Scanning Land mine Detectors  

International Nuclear Information System (INIS)

This article presents and discusses the upgrading processes which were performed to increase the detection capability of the Egyptian Scanning Land mine Detectors, ESCALAD system. The upgrading processes include different designs which were made to mount the detectors tray. These arrangements aim to overcome the effect of the soil surface roughness and stand off distance on the scanning capability. Also a more stable and reliable PCI data acquisition board with fast Digital I/O up to 125 M/s was used. Moreover, data acquisition software which uses different algorithms for background subtraction and 2D-image filtration was build and developed. The software was build using Qt-cross-platform application and other Linux based packages. Examples of images constructed from experimental measurements using the upgraded and modified software are given and discussed. The obtained displayed images show more developed improvements and reliability.

2013-07-01

207

Examination of an Egyptian mummy - stereolithography applied  

International Nuclear Information System (INIS)

This paper describes the techniques of three dimensional imaging and stereolithography based on serial CAT-scans applied to the examination of the skull of an Egyptian mummy. Both the three dimensional image and the polymeric cast of the mummy skull presented finer details. It was confirmed that the subject was a male, approximately 30 - 35 years old. Fracturing of the ethmoid bone, e=sequelae to the removal of the brain, was observed in both types of presentations. Apart from this and signs of parodontitis, no pathology was observed. Stereolithography is a most powerful, non-destructive approach to the study of mummies. It might solve some of the problems of reburials, and further be of value in forensic medicine and paleo-ontology. (authors)

1994-05-03

208

Egypt between the Superpowers: Continuity or Change in Egyptian Foreign Policy under Mubarak.  

Science.gov (United States)

This thesis deals with Egyptian foreign policy under President Mohamed Hosni Mubarak. The emphasis is on Egypt's orientation between superpowers, and the dilemma of continuity or change. The Egyptian leadership's perception of their country's internationa...

M. Y. Amer

1984-01-01

209

Stock Accumulation, Export Demand, and Appropriate Export Prices for Egyptian Extra Long Staple Cotton.  

Science.gov (United States)

The recent rapid accumulation of unsold Egyptian cotton stocks is becoming a serious problem. The paper explores the possibility of alleviating the stock problem by increasing exports. Accordingly, three export demand functions for Egyptian extra-long sta...

D. G. Heckerman H. A. Khedr H. Kheir El-Din

1982-01-01

210

Enhancement of the folate content in Egyptian pita bread  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Egypt has a high incidence of neural tube defects related to folate deficiency. One major food source for folate is pita (baladi bread, which is consumed daily. Bioprocessing (e.g. germination has been reported to increase the folate content in cereals. The aim was to produce pita bread with increased folate content using germinated wheat flour (GWF.Methods: Prior to milling the effects of germination and drying conditions on folate content in wheat grains were studied. Pita bread was baked from wheat flour substituted with different levels of GWF. The folate content in dough and bread and rheological properties of dough were determined.Results: Germination of wheat grains resulted in, depending on temperature, 3- to 4-fold higher folate content with a maximum of 61 µg/100 g DM (dry matter. The folate content in both flour and bread increased 1.5 to 4-fold depending on the level of flour replacement with GWF. Pita bread baked with 50% sieved GWF was acceptable with respect to colour and layer separation, and had a folate content of 50 µg/100 g DM compared with 30 µg/100 g DM in conventional pita bread (0% GWF.Conclusion: Using 50% GWF, pita bread with increased folate content, acceptable for the Egyptian consumer, was produced. Consumption of this bread would increase the average daily folate intake by 75 µg.

Cornelia M. Witthöft

2012-04-01

211

Language Maintenance and Transmission: The Case of Egyptian Arabic in Durham, UK  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This sociolinguistic micro-level study examines experiences of five Egyptian families, living in Durham, UK, who are trying to transmit Egyptian Arabic to their children. Answers to the following questions are sought: first, how these language-minority families describe barriers to and supports for passing on Egyptian Arabic to their children? Second, what language decisions they make in order to fulfill their roles? Third, how such decisions are linked to their identity as Egyptians...

Yasser Ahmed Gomaa

2011-01-01

212

Connecting Philosophy of Ancient Egyptians to Modern Thinking  

Directory of Open Access Journals (Sweden)

Full Text Available Problem statement: Associating any knowledge from ancient Egyptians to modern civilization and thinking was important and had its own value. The process of understanding knowledge related to ancient Egyptians is actually based on the nature of philosophical thought. Approach: In the discussion of ancient Egypt philosophy, it is important to look at it from the perspectives of the four branches of philosophy; metaphysics, epistemology, axiology and logic. Metaphysics has two elements, which are ontology and cosmology. Arguments in ontology explain why most activities of people from the ancient Egypt involved agriculture and how they perceived their lives in the midst of this activity, this includes the concept of human creator; treatment to man and woman; and Egyptians? Gods and Goddesses. In addition, cosmology analyses the universe; everything inside and out of it, as well as what makes them stay and move. Results: Whereas, epistemology refers to how ancient Egyptians appreciated the existence of knowledge among them by considering the sources, types, categories and importance of particular knowledge that was gained in different ways. Besides, the aspects of axiology are also discussed here, especially in the ancient Egypt?s hieroglyphics. This writing discusses the level of aesthetical value posed by all these Egyptians, even at the time of about 3000 B.C. They could discuss to form pictographic as their written language. This activity lasted for thousands of years. Conclusion: Last but not the least, logic is another aspect that can be used in the discussion across metaphysics, epistemology and also axiology, for instance, the thinking of the philosophy behind Egyptians life. This writing relates the philosophy of ancient Egypt with the life of the modern world, not only in Egypt, but also in another part of the world, which exist from the impact of the philosophy of ancient Egypt. Modern views of Egyptians? thinking are often vastly based on what their people had and thought of in the ancient days.

Aminuddin Hassan

2012-01-01

213

A Comprehensive Study of Egyptian Arabic. Volume Four. Lexicon Part I: Egyptian Arabic-English; Part II: English-Egyptian Arabic (A Preliminary Edition).  

Science.gov (United States)

This is the last of four instructional volumes designed for the intermediate-advanced student of Egyptian Arabic. The course deals with the language, culture, customs, and traditions of Egypt. The present volume constitutes a vocabulary, with word lists divided into 34 categories. High frequency vocabulary items are emphasized. (JB)

Abdel-Massih, Ernest T.; And Others

214

CHEMICAL DETERIORATION OF EGYPTIAN LIMESTONE AFFECTED BY SALINE WATER  

Directory of Open Access Journals (Sweden)

Full Text Available Salt forms are aggressive deterioration problems, which occur on all stone surfaces, mortars and renderings through saline solutions transferred to the stone pores. Deterioration of Egyptian limestone is primarily due to water-soluble salts. The formation of these salts on calcareous stone is the most important chemical reaction involving saline water to cause stone degradation. The study explains the different deterioration phenomena and alteration mechanisms that lead to the formation of salt crusts on archaeological limestone surfaces. A simulation laboratory conditions has been created to correspond to the aggressive deterioration environments dominating in most archaeological sites in Egypt. Different scientific instruments such as EDX attached with SEM, XRD, AAS, and ISE have been used to study and evaluate the chemical and mineralogical components of salt crusts and to assess the major ions accumulated within the stone pores. The results show that there are aggressive forms of salt affecting the weathered samples; especially those subjected to Na2SO4 followed by samples exposed to 1:1 NaCl and Na2SO4. The high level of Cl- and SO4-- concentrations found on the decayed stone surfaces gives an accurate evidence of salt migration. The degradation phenomena resulted from salty decay actions has occurred directly through complex mechanisms depending on certain specific factors. These factors such as mineralogical composition of stones, major deterioration factors responsible for the natural variety in stone reactivity and adsorption of some salty ions as Cl- and SO4--. Thereafter production of gypsum, halite and other species of salty crusts, in addition to the dominated environmental conditions.

Mohammed EL-GOHARY

2011-03-01

215

Uranium potentialities in the Egyptian phosphate  

International Nuclear Information System (INIS)

The phosphate deposits of Egypt are of Upper Cretaceous age and are known to occur in three main provinces: The Red Sea Coast, Nile valley and Abu Tartour plateau near El Kharga Oasis, western desert. During the last several years 600,000 tons of phosphate rock were produced annually. Half of this amount are commercially processed for fertilizer and phosphate chemicals while the rest are exported. Confirmed reserves are estimated to be 30 million tons, 75 million tons and 700 million tons at the Red Sea Region, Nile valley, and Abu Tartour plateau respectively. This can show the importance of the phosphate rocks as a potential source of uranium. Uranium analyses previously reported and presented obtained for about 3000 samples in the different studied areas. In general it is within the range of 12 to 185g uranium/ton ore. Uranium seldom if ever forms its own minerals within the rock but it is caught up in the framework of the phosphate minerals. In fact the uranium is found to be completely in the tetravalent state at Abu Tartour phosphorites. On the other hand the estimated tetravalent uranium is 70 and 80% for the Nile Valley and The Red Sea Coast phosphates respectively. Moreover, post depositional enrichment of uranium in the Red Sea phosphate was less than that of the Nile Valley and greater than that of Abu Tartour phosphate. The uranium potentialities in the Egyptian phosphates could be estimated as 80,000 tons uranium

1988-03-06

216

Modular categories, integrality and Egyptian fractions  

CERN Document Server

It is a well-known result of Etingof, Nikshych and Ostrik that there are finitely many inequivalent integral modular categories of any fixed rank $n$. This follows from a double-exponential bound on the maximal denominator in an Egyptian fraction representation of $1$. A na\\"ive computer search approach to the classification of rank $n$ integral modular categories using this bound quickly overwhelms the computer's memory (for $n\\geq 7$). We use a modified strategy: find general conditions on modular categories that imply integrality and study the classification problem in these limited settings. The first such condition is that the order of the twist matrix is $2,3,4$ or $6$ and we obtain a fairly complete description of these classes of modular categories. The second condition is that the unit object is the only simple non-self-dual object, which is equivalent to odd-dimensionality. In this case we obtain a (linear) improvement on the bounds and employ number-theoretic techniques to obtain a classification f...

Bruillard, Paul

2010-01-01

217

Social media in the 2011 Egyptian uprising.  

Science.gov (United States)

This paper uses Gallup poll data to assess two narratives that have crystallized around the 2011 Egyptian uprising: (1) New electronic communications media constituted an important and independent cause of the protests in so far as they enhanced the capacity of demonstrators to extend protest networks, express outrage, organize events, and warn comrades of real-time threats. (2) Net of other factors, new electronic communications media played a relatively minor role in the uprising because they are low-cost, low-risk means of involvement that attract many sympathetic onlookers who are not prepared to engage in high-risk activism. Examining the independent effects of a host of factors associated with high-risk movement activism, the paper concludes that using some new electronic communications media was associated with being a demonstrator. However, grievances, structural availability, and network connections were more important than was the use of new electronic communications media in distinguishing demonstrators from sympathetic onlookers. Thus, although both narratives have some validity, they must both be qualified. PMID:24798232

Brym, Robert; Godbout, Melissa; Hoffbauer, Andreas; Menard, Gabe; Zhang, Tony Huiquan

2014-06-01

218

Estimation of human body built in Egyptians.  

Science.gov (United States)

Identification of an unknown body and prediction of growth from specific body measurements are very important tasks in the fields of physical anthropology and forensic medicine. Height and weight are two factors among others required to establish individuality of an unidentified body. In the present work, an attempt has been made to calculate the stature and weight from percutaneous tibial length and bimalleolar breadth. The study was carried out on 1000 living Egyptian individuals comprising 500 males and 500 females; their age was between 19 and 21 years. A significant positive correlation between stature and tibial length in both sexes was recorded. The coefficient of determination showed that 56% of variation in stature was due to tibial length and bimalleolar breadth in males, while in females the coefficient of determination was 23%. On the other hand, the coefficient of determination for weight showed that 11% of variability in weight was due to tibial length and bimalleolar breadth in males, while in females it was 5%. Linear regression analysis was done for all variables in all cases. The regression equation formulae are helpful in the estimation of stature and weight of the deceased from tibial length and bimalleolar breadth when leg or foot is the only portion available for autopsy examination. PMID:16081233

El-Meligy, Manal M S; Abdel-Hady, Randa H; Abdel-Maaboud, Ragaa M; Mohamed, Zaghloul T

2006-05-25

219

Early Hepatic Complication in First Year after Bone Marrow Transplantation in Major Beta Thalassemic Patients  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Bone marrow transplantation is a good therapeutic modality for beta thalassemia. Liver complications are one of the major causes of morbidity and mortality following BMT. Determination of the factors of liver injury leads to earlier diagnosis after BMT and improves prognosis. Method: We studied 113 major Beta thalassemic patients who have been transplanted from 1990- 2000 in bone marrow transplantation center of Shariati Hospital. 62 were male and 51 were female. 27 pa¬tients were class one, 56 were class two and 30 were class three. The median age of each class were 6.5, 6.3 and 8.7. Conditioning regimen consisted of busulfan (3.5-4mg/Kg and cyclophophamide (40-50mg/Kg.For GVHD prophylaxis we gave cyclosporine ± metothoroxate. Grade of liver fibrosis de¬fined by biopsy in all patients before BMT. All patients and their donors tested for HBSAg, HBSAb, HCVAb, CMVAb with RIA method. We assessed causes of liver dysfunction before and after trans¬plantation and effect of high ferritin level on liver function."nResults: Hepatic dysfunction in first year after transplantation was seen in 86 (76% patients. Causes of liver dysfunction were consisted of 53.1% GVHD, 15.93% cyclosporine hepatotoxicity, 7.07% condi¬tioning regimen hepatotoxicity and VOD. In all three classes hepatic GVHD, cyclosporine toxicity, death and normal liver function post BMT had significant relation with hepatic dysfunction before BMT (P=0.001. In patients with ferritin level more than 1000, there were significant hepatotoxicity with conditioning regimen (P=0.001. 17 (15.04% of patients have been died. Discussion: According to our study hepatic GVHD (%53.1 is the most common cause of hepatic dys¬function in all three classes.

Iravani M

2005-07-01

220

Association of factor V Leiden mutation with deep vein thrombosis among Egyptian cases  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Deep vein thrombosis (DVT is a blood clot in a major vein, usually in the legs and/or pelvis. If part of the thrombus breaks off, it becomes an embolism, which can travel through the heart and block the arteries to the lungs. Factor V Leiden (FVL is a common genetic risk factor for hereditary hypercoagulability disorder in several populations. The present study investigates the association of FVL mutation with DVT among Egyptian cases. Patients & methods: The study included 44 cases (16 males and 28 females with an age range of 20 to 80 years in addition to 211 healthy unrelated controls of matched age and sex. A multiplex allele-specific PCR amplification was conducted for assignment of FVL gene mutation (G1691A. Results: Cases having the mutant allele A (AA and AG genotypes were significantly higher than controls (38.6% vs. 18.5%; P < 0.05, OR= 2.78 and CI 95%, 1.380­5.589. Conclusion: These results concluded that FVL mutation has a high frequency and positive association with the occurrence of deep vein thrombosis among Egyptian cases

Sherif H. Abdeen, **Rizk El-Baz, *Wessam El-Gazar, **Ahmad Settin

2010-06-01

 
 
 
 
221

Egyptian mothers learn to treat diarrhoeal diseases.  

Science.gov (United States)

Public health planners in Egypt have launched a campaign to teach mothers how to save the lives of their children by treating diarrhea with oral rehydration therapy. Timely replacement of body fluids and salts can prevent the death of diarrhea victims. Egypt needs an estimated 5 million packets of salt and sugar annually to save the children. Each packet costs less than 10 cents. The prescribed drink comprises 3.5 gm of sodium chloride (table salt), 2.5 gm of bicarbonate (baking soda), 1.5 gm of potassium chloride, 20 gm of glucose or 40 gm of sucrose dissolved in a liter of drinking water. Its suitability for widescale applications has been established in a pilot project carried out in Egypt in 1977 with help from 2 UN organizations. The study concluded that the lifesaving treatment is within the technical skills of every mother, given guidance by a nurse. Packets of the mixture are currently produced industrially by a state owned concern distributed throughout the country under the trade name Rehydran. They are also produced in many regions by local doctors and the pharmacies of primary health care units, but it takes considerably more than the production and distribution of the mixture to save the lives of the children. As diarrhea and malnutrition are closely linked, nutrition education is an important aspect of the Egyptian campaign. Mothers are being taught a whole range of essential skills at demonstrations by medical workers. The public education program is supported by the mass communication media. The training and reorientation of health workers is being conducted simultaneously to absorb them in the widening campaign. The longterm intention of the campaign is to precede communal action toward eliminating the conditions contributing to illness. Cairo alone plans to triple its safe drinking water supplies within a year and a heated debate is now taking place over proposals for rebuilding the city's aged sewage disposal system. PMID:12339315

1982-01-01

222

Diagnostic Value of Fructosamine and Glycosylated Hemoglobin in Estimating Blood Glucose Level in Diabetic Patients with Thalassemia Major  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Objective: Diabetes mellitus is one of complications that thalassemia major patients face with. Hence, blood glucose monitoring is of vital importance to these patients. Because of high level of fetal hemoglobin in these patients, the measurement of hemoglobin A1c is not reliable and should be displaced by fructosamine test. Material and Methods: The current descriptive study was carried out on 33 beta-thalassemia major patients afflicted with diabetes mellitus (21 female and 12 male cases. Blood glucose level, fructosamine, hemoglobin A1c, serum ferritin and fetal hemoglobin were measured. Results: Blood glucose levels are 204±103 mg/dL and 221±101 mg/dL (p=0.63; fetal hemoglobin levels are 9%±7% and 13%±9% (p=0.22; serum ferritin levels are 1744±1534 ng/mL and 3253±1773 ng/mL (p=0.96 in female and male patients, respectively. The level of fructosamine (42±124 mmol/L and glycosylated hemoglobin (8.9%±1.8% are correlated significantly (r=0.69, p<0.01. Both Hemoglobin A1c (r=0.75, p<0.01 and fructosamine (r=0.54, p<0/01 show a significant correlation with blood glucose level. Conclusion: In diabetic thalassemia major patients with frequent blood transfusion, the level of fructosamine and glycosylated hemoglobin are related significantly, therefore; they can be used alternatively. Keywords: Thalassemia major; Fructosamine; Hemoglobin A1c; Diabetes Mellitus

Kosaryan, M. (MD

2013-01-01

223

Overview of the Egyptian Radiation Monitoring Network and Radioactivity Levels of the Egyptian Territories  

International Nuclear Information System (INIS)

The Chernobyl accident in 1986 arose much concern throughout the world regarding the detection of contamination, control of contaminated food, related legislation and environmental monitoring. In Egypt, the environmental radioactivity monitoring program involves the establishment of a radiation monitoring network stations for continuous monitoring of ambient gamma radiation levels in the air, water, aerosols, dust particles and conventional gas pollutants. The network consists of 42 field stations for gamma monitoring of air, 14stations for beta aerosols and 15 stations for conventional pollutants. soil samples adjacent to the stations distributed all over the Egyptian territories have been collected and analyzed by gamma spectrometry. The natural radionuclides K40, U-238 series Th-232 series and the global fallout Cs-137 are found in all the collected samples. The absorbed dose rates are calculated and presented

2001-03-01

224

Geographic information system for the Egyptian electrical network  

Energy Technology Data Exchange (ETDEWEB)

This presentation describes the project to provide a geographic information system for the Egyptian electrical network and its benefits and results. The topics of the presentation include international financial and developmental assistance in the project, planning, initial mapping tasks and plans for expansion, and benefits of the mapping and facilities management system.

Abu-Alam, Y.

1994-12-01

225

Cultural Considerations for Evaluation Consulting in the Egyptian Context.  

Science.gov (United States)

Reflecting on his experiences as an evaluation consultant at the Suez Canal University Faculty of Medicine in Egypt the author discusses: (1) implications of the Egyptian political context; (2) adapting to the host culture; and (3) maintaining distance from one's own culture. Personal qualities to complement the recommended naturalistic methods…

Seefeldt, Michael F.

1985-01-01

226

Economic Indicators of Efficiency of the Egyptian Cotton Spinning Industry.  

Science.gov (United States)

Egyptian long-staple cotton which is exported at a relatively high price and is used by importing countries to spin a fine yarn, has been increasingly used domestically to spin coarse and medium yarns which are then used domestically or exported. The pape...

H. Khedr H. Kheir El-Din E. Monke

1982-01-01

227

Application of Moessbauer spectroscopy to study archaeological Egyptian pottery  

International Nuclear Information System (INIS)

Moessbauer spectra have been used as ''fingerprints'' in obtaining information an ancient Egyptian pottery and in fine art. An empirical relation has been found that connects the natural radiation dose with the intensity ratio of the two non-magnetic central peaks. It was suggested that this relation be used for dating ancient pottery. 8 refs, 13 figs, 2 tabs

1988-01-01

228

A Comprehensive Study of Egyptian Arabic. Volume Three: A Reference Grammar of Egyptian Arabic (A Preliminary Edition).  

Science.gov (United States)

This is the third of four instructional volumes designed for the intermediate-advanced student of Egyptian Arabic. The course deals with the language, culture, customs, and traditions of Egypt. The present volume constitutes a reference grammar, arranged alphabetically by grammatical and linguistic terms. A bibliography is appended. (JB)

Abdel-Massih, Ernest T.; And Others

229

Combined Therapy with Deferiprone and Desferrioxamine as Compared to Desferasirox on Ventricular Function in Thalassemia Major Patients  

Directory of Open Access Journals (Sweden)

Full Text Available AbstractBackgroundMyocardial iron overload is the leading cause of death in patients with beta-thalassemia major.Combined therapy with deferiprone(DFP and desferrioxamine (DFOwere suggested to be more effective than deferasirox(DFX for removing heart iron. Deferasirox has recently been made available but its long-term efficacy on cardiac function has not yet been established. Our study aimed to compare the effectiveness of deferiproneanddesferrioxaminewith deferasiroxon ventricular function in thalassemia major patients.Materials and MethodsIn this clinical trialstudy,72thalassemia major (TM patients were randomised to receive either deferipronecombined with desferrioxamineanddeferasirox ,and thencardiac function were evaluated. Data were analysed for left ventricular ejection fractions(LVEFat baselinebyechocardiograpy, following 12 months of treatment.Results72 TM patientswere enrolled in this study lasting 12 months,36 TMwere placed on DFP/DFO (DFP,50–86 mg/kg body weight; DFO, 24–52 mg/kg body weigh,36received DFX(range 18–40 mg/kg body weight.In 36 patients receiving combined therapy, left ventricular ejection fractionincreased from 59.3+/-5.7% to 63.7+/-5.1% (p=0.001 over 12 months [baseline LVEF values 56-61%]. deferasirox showed no change in LVEF (p = 0.93.We found improvement of left ventricular ejection fractionsin the deferiprone combined with desferrioxamine versus the deferasirox group (P = 0.008.ConclusionThe patients treated with combined therapy with deferiprone and desferrioxamineshowed better systolic ventricular function compared to the patients treated with deferasirox.The patients treated with combined therapy with deferiprone and desferrioxamine showed better systolic ventricular function compared to the patients treated with deferasirox.

Sartipzade NH

2012-09-01

230

Striking presence of Egyptian blue identified in a painting by Giovanni Battista Benvenuto from 1524.  

Science.gov (United States)

Egyptian blue has been identified in a painting from 1524 by the Italian artist Ortolano Ferrarese (Giovanni Battista Benvenuto). Egyptian blue is the oldest known synthetic pigment, invented by the Egyptians in the fourth dynasty (2613-2494?BC) of the Old Kingdom and extensively used throughout Antiquity. From about 1000?A.D., it disappeared from the historical record and was only reinvented in the late nineteenth and early twentieth century. The discovery of Egyptian blue in Ortolano Ferrarese's painting from 1524 shows that Egyptian blue was in fact available in the period from which it is normally considered not to exist. The identification of Egyptian blue is based on optical microscopy supported by energy-dispersive spectroscopy and visual light photon-induced spectroscopy, and finally confirmed by Raman microspectroscopy. PMID:21678119

Bredal-Jørgensen, Jørn; Sanyova, Jana; Rask, Vibeke; Sargent, Maria Louise; Therkildsen, Rikke Hoberg

2011-09-01

231

Histological patterns of idiopathic steroid resistant nephrotic syndrome in Egyptian children: A single centre study  

Science.gov (United States)

Background Background: Idiopathic steroid resistant nephrotic syndrome (ISRNS) represents about 10-20% of children with nephrotic syndrome with variable outcome. Objectives To determine the histological patterns of ISRNS in Egyptian children and the histological details of the commonest types which might be the reason for the steroid resistance. Patients and Methods The study included 53 cases with ISRNS. Their renal biopsies were retrieved from the archive of Electron microscopy unit and pathology department, Ain Shams University Specialized Hospital (ASUSH) in the duration from 2005-2011. The biopsies were examined histologically, with immunohistochemistry, and by electron microscopy. Results They were 36 males (67.9%) and 17 females (32.1%), the age at diagnosis ranged from 1.5- 16 years with a mean of 6.71 years. Lower limb oedema was the commonest presentation (100%), haematuria was revealed in (17%) of cases. Histological examination showed three major patterns; Focal segmental glomerulosclerosis (FSGS) in 30.2%, minimal change glomerulopathy (MCG) in 24.5% and IgA nephropathy in 13.2 %. Mesangial hypercellularity was very common among MCG patients (85.3% ±6.7). Tubulointerstitial inflammation and fibrosis were common among cases with IgA nephropathy (40.4% ±11, 53.7% ±8 respectively). Conclusions ISRNS in Egyptian children could be attributed mainly to three major diseases (FSGS, MCG and IgA nephropathy). Mesangial hypercellularity and severe tubulointerstitial disease might be the major causes for steroid resistance in MCG and IgA nephropathy respectively. Renal biopsy with electron microscopy examination should be done for all children with nephrotic syndrome at first time of presentation for proper assignment of treatment protocol.

Ibrahim Seif, Elham; Abdel-Salam Ibrahim, Eman; Galal Elhefnawy, Nadia; Ibrahim Salman, Manal

2013-01-01

232

Physical fitness status of Egyptian children aged 9-18 years.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Male (n = 399) and female (n = 311) Egyptian school children, aged 9-18 yrs, had their fitness evaluated using the 6-item AAHPER test. Comparisons of the 50th percentiles of the AAHPER norms with the median scores for the Egyptian sample revealed that the latter were substantially below average fitness levels. Egyptian boys performed significantly better than girls on all comparable test items, even when the effects of age, height, and weight were held constant by covariance. Eight weeks of t...

Elnashar, A. M.; Mayhew, J. L.

1984-01-01

233

The implementation of world class manufacturing techniques in Egyptian manufacturing firms: An empirical study  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Purpose - The purposes of this paper are to illustrate how the world class manufacturing (WCM) techniques which could be described as outperforming the industry's global best practices have been implemented in the Egyptian manufacturing firms, to identify the critical driving and resisting forces toward WCM techniques implementation in Egyptian manufacturing firms, and to provide guidelines for the successful implementation of WCM by Egyptian manufacturers. Design/methodology/approach - The d...

Salaheldin, S. I.; Eid, R.

2007-01-01

234

The "Challengers":The driving forces behind the youth's demand for change in the Egyptian Uprising  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This study reflects on what were the most important motivational factors for the Egyptian youth to participate in the 25th of January 2011 revolution. By applying a conceptual framework from social movement theory, it attempts to explain what paved the way for the Egyptian youth's participation in the 18 days of protest in Tahrir Square. The analysis is based on qualitative interviews conducted with Egyptian youth who participated in the revolution, as well as on interviews with area speciali...

Mohn, Giti Carli

2012-01-01

235

The "Challengers": The driving forces behind the youth's demand for change in the Egyptian Uprising  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This study reflects on what were the most important motivational factors for the Egyptian youth to participate in the 25th of January 2011 revolution. By applying a conceptual framework from social movement theory, it attempts to explain what paved the way for the Egyptian youth's participation in the 18 days of protest in Tahrir Square. The analysis is based on qualitative interviews conducted with Egyptian youth who participated in the revolution, as well as on interviews with area speciali...

Mohn, Giti Carli

2012-01-01

236

Discrimination Capacity of RAPD, ISSR and SSR Markers and of their Effectiveness in Establishing Genetic Relationship and Diversity among Egyptian and Saudi Wheat Cultivars  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Problem statement: Yield crop cultivars and landraces are valuable sources of genetic variations that the knowledge and implication of these variations are critical in the plant breeding programs. our major objective of this study is investigating the discriminating capacity of RAPD, ISSR and SSR markers and of their effectiveness in establishing genetic relationship and diversity among Egyptian and Saudi wheat cultivars. Approach: Eleven wheat cultivars and landraces collected ...

2012-01-01

237

"Evaluation Of compliance To Iron Chelation Therapy With Defe-Roxamine In Patients With Major Thalassemia In Iran In 2004 "  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Aim: With the introduction of long term subcutaneous administration of Deferoxamine there has been a decline in the morbidity and mortality of transfusion-dependent beta thalassemia patients. But parenteral iron chelation therapy is still a burden and a major reason for unsatisfactory compliance and places an additional psychological burden on the patients. There are some factors contributing to low compliance in these patients. To evaluate compliance to Deferoxamine and barriers of non adherence and assessment the prevalence of depression and it’s association with compliance. Materials and Methods: 205 patients with major thalassemia in children medical center older than 6 years old were included. They were classified in 3 groups by compliance index (CI: No. of days of treatment per one month/No. of treatment days prescribed by physician. CI>75 % was considered good ,CI< 50-75%: moderate,CI<50%:weak and 3d group the patients without compliance. For assessment of depression: Beck Depression questionnaires were given to the patients older than 18 years old and Children Depression Inventories (CDI“kovacs” were given to the rest Results: Of 205 patients (110 females (54% and 95 males (46%, 13.3% were non compliant, 14% had poor compliance, 62.7% had good compliance. Females were more compliant than males (P=0.034. Compliance improved in older age groups meaningfully (P=0.037. There was negative association between compliance and serum ferritin level (P=0.02. 22% of children and 12% of Adults had severe depression according to the questionnaires. There was no association between compliance and depression. The most prevalent problem rgarding Desferal injection was local reactions in injection site (83%. Conclusion: As oral chelation therapies are not used routinely, more investigations regarding the noncompliance must be considered; and this method of chelation therapy must be encouraged. Compliance is a multifactorial problem, so the solution to which requires close interaction between the patient, the family and community.

M. Izadyar

2006-06-01

238

Practice and awareness of health risk behaviour among Egyptian university students.  

Science.gov (United States)

Health risk behaviour contributes markedly to today's major killers. A descriptive cross-sectional study was conducted to assess current awareness and practice of health risk behaviour among Egyptian university students. Only 121 students (18%) were practising risky behaviour. Tobacco use, alcohol and drugs use and risky sexual behaviour were positively correlated. Multiple regression analysis revealed that the main determinants of risky behaviour were being a male, of older age, having a high allowance and having no attention to danger. About 30% of students lacked adequate knowledge on AIDS. Most of those who had sexual relationships did not use contraceptives or any method of protection from sexually transmitted infection. Main sources of knowledge were the media (38%) then peers (30%). PMID:16201711

Refaat, A

2004-01-01

239

Egyptian imprints on Geto-Dacian magical medicine.  

Science.gov (United States)

Several characteristics of Egyptian culture and civilization could be identified in prehistoric and ancient historic Geto-Dacian territories, belonging to modern Romania (Fig. 1). From early times, magic, religion and philosophy have been part of pre-scientific medicine. Therefore these aspects are to be tackled when speaking of medicine in mythological or legendary ages. Progress of ancient Geto-Dacian medicine was principally ascribed to the interface of local civilizations with ancient Egypt, Greece and Rome. Such connections were well documented and understood in historic times and were mainly based on texts of renowned Greek and Roman historians. Egyptian impact upon Dacia, -the ancient name of today's Romania-, was often explained in terms of indirect Greek- or Roman-mediated influences.The Greek and then the Roman colonies on the Black sea shore, together with later Roman colonies in Dacia Felix, founded in the heart of Transylvania, enabled access for Romania to Mediterranean cultures, including that of Egypt. PMID:21657103

Baran, Dana

2010-12-01

240

Education in Egypt and Egyptian response to eclipses  

Science.gov (United States)

Astronomy and space science educations started in Egypt at the university level since 1939 at Department of Astronomy and Meteorology, Cairo University. Undergraduate and graduate education in Egypt will be discussed in this work. About 15 students yearly obtain their PhD degrees in Astronomy from the Egyptian universities. Seven International groups under my supervision have done the total solar Eclipse observations that took place on 29 March 2006, in El-Saloum (Egypt). The results of observations and photos will be discussed. Egyptian-French group have done the total solar eclipse observations that took place on 25 February 1952 in Khartoum by using Worthington Camera. The research groups of Astrophysics in Cairo University and Helwan observatory are interested in the fields of solar physics, binary stars, celestial mechanics, interstellar matter and galaxies. Most of the researches have been published in national scientific journals, and some of them were published in International Journals.

Hady, A.

2006-08-01

 
 
 
 
241

Ancient Egyptian chronology and the astronomical orientation of pyramids  

Science.gov (United States)

The ancient Egyptian pyramids at Giza have never been accurately dated, although we know that they were built approximately around the middle of the third millennium BC. The chronologies of this period have been reconstructed from surviving lists of kings and the lengths of their reigns, but the lists are rare, seldom complete and contain known inconsistencies and errors. As a result, the existing chronologies for that period (the Old Kingdom) can be considered accurate only to about +/-100 years, a figure that radiocarbon dating cannot at present improve. Here I use trends in the orientation of Old Kingdom pyramids to demonstrate that the Egyptians aligned them to north by using the simultaneous transit of two circumpolar stars. Modelling the precession of these stars yields a date for the start of construction of the Great Pyramid that is accurate to +/-5 yr, thereby providing an anchor for the Old Kingdom chronologies.

Spence, Kate

2000-11-01

242

Electrical properties and mineralogical investigation of Egyptian iron ore deposits  

International Nuclear Information System (INIS)

Electrical properties and X-ray diffraction of 20 hematite sandstone samples of the most economically interesting Egyptian iron ore deposits have been investigated. Samples were collected from two different areas in Egypt (Aswan and Bahariya). Complex impedance measurements in the frequency range from 10 Hz to 100 kHz were performed at room temperature (?20 deg. C). The observed dielectric behavior was characterized by Maxwell-Wagner interfacial polarization at low frequencies and bulk polarization at relatively higher frequencies. The frequency dependence on conductivity shows a classical relaxation behavior followed Jonscher's universal law. The measured electrical properties vary strongly with the frequency and sample composition. The difference in the electrical properties may be attributed to the fluctuations in the concentration of the sample constituents and to the degree of heterogeneity of the grains. The XRD-patterns of Egyptian iron ore deposits prove that the main phases are hematite and quartz

2009-03-15

243

Determination of some radioactive and trace elements in egyptian foodstuffs  

International Nuclear Information System (INIS)

This work has been carried out to investigate the levels of radioactivity and the concentration of some trace elements in different samples of foodstuffs, which were collected from eight selective Egyptian governorates (Cairo, Alexandria, Elgharbia ,El Arish, Port Said, Ismaillia, Assuit and Aswan). These samples were chosen to represent nearly most foodstuffs of egyptian according to their habits (Cereals, meat, vegetables, fruits and dairy products). Gross alpha, beta and gamma radiation levels had been determined using low background alpha/beta/gamma counting system with 3phoswish detector. Certain trace elements representing the essential elements of the body such as Zn, Cu and K and a toxic element such as Pb were determined using inductivity coupled plasma - Atomic emission spectroscopy (ICP - AES) in case of Zn, Cu and Pb while flame photometry was used in case of K

1998-01-01

244

Chemical analysis of Yemeni archaeological cheramics and the Egyptian enigma  

International Nuclear Information System (INIS)

Archaeological reconnaissance in Yemen produced samples of mediaeval Islamic ceramics in a 100 km2 region. The ceramics dated from 700 A.d. to 1750 A.D. and initial research indicated that they were all locally made products. 12 types of ceramics were selected for sampling on the basis of stylistic decoration. Six laboratory samples of each type were subjected to neutron activation analysis for the short-lived isotope producing elements using the SLOWPOKE reactor at the University of Toronto. A comparison with Egyptian pottery was carried out. The statistical analysis conducted on the Yemeni and Egyptian pottery produced discrete differences in their elemental composition which the archaeologist and the chemical scientist might not otherwise recognise. It is concluded that artifacts must be analyzed with due respect given to the archeological context, the elemental chemistry, and sound statistical procedures. (author)

1987-03-01

245

Does Facebook Matter in Egyptian Graduate Environment? A Marketing Perspective  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The current study is exploratory, and it aims at uncovering the potential role of Facebook in Egyptian university environment. The research based on 127 questionnaires. It was found that; 42% of the respondents use Facebook for educational purpose; around 85% use Facebook to be in touch with their teachers; more than 75% use Facebook to contact the faculty administration; more than 70% of students are convinced that they have added value when using Facebook in the educational context...

Ahmad Yahia Ebeid

2012-01-01

246

Nile Crossings: Hospitality and Revenge in Egyptian Rural Narratives  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This essay looks at acts of hospitality and revenge as constituent elements of a broad social code in rural Egyptian narratives. By looking at five stories in particular, I argue that hospitality and revenge work in complementarity, and that they often trespass and blur each other’s social and literary borders, creating ambiguity and complexity in the stories. The traditional rules that govern hospitality are at times challenged or inverted by hostile intentions, and revenge may be exacted ...

Granara, William E.

2010-01-01

247

Molecular Genetic Study of Egyptian Patients with Macular Corneal Dystrophy  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Aim: To identify the underlying genetic defect in Egyptian patients with macular corneal dystrophy (MCD). Methods: A clinical and molecular genetic study was performed on eleven patients from six families with MCD. Clinical diagnosis was confirmed by slit lamp biomicroscopy and histopathological examination of corneal buttons following keratoplasty. The coding region of the carbohydrate sulfotransferase (CHST6) gene was amplified by polymerase chain reactio...

2010-01-01

248

Quantitative analysis of ancient Egyptian pigments by external PIXE  

Science.gov (United States)

Pigments painted on Egyptian excavations in the 18th Dynasty were analyzed successfully by external PIXE with the aid of the X-ray diffraction. A white pigment was composed of Mg 3Ca(CO 3) 4; red: ?Fe 2O 3, ?FeO·OH and AsS; pink: mixtures of white and red pigments; yellow: ?FeO·OH and As 2S 3; and blue: CaO·CuO·4SiO 2.

Uda, M.; Tsunokami, T.; Murai, R.; Maeda, K.; Harigai, I.; Nakayama, Y.; Yoshimura, S.; Kikuchi, T.; Sakurai, K.; Sasa, Y.

1993-04-01

249

Quantitative analysis of ancient Egyptian pigments by external PIXE  

International Nuclear Information System (INIS)

Pigments painted on Egyptian excavations in the 18th Dynasty were analyzed successfully by external PIXE with the aid of the X-ray diffraction. A white pigment was composed on Mg3Ca(CO3)4; red: ?Fe2O3, ?FeO.OH and AsS; pink: Mixtures of white and red pigments; yellow: ?FeO.OH and As2S3; and blue: CaO.CuO.4SiO2. (orig.)

1993-04-01

250

Peanut sensitization in a group of allergic Egyptian children  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background There are no published data on peanut sensitization in Egypt and the problem of peanut allergy seems underestimated. We sought to screen for peanut sensitization in a group of atopic Egyptian children in relation to their phenotypic manifestations. Methods We consecutively enrolled 100 allergic children; 2-10 years old (mean 6.5 yr). The study measurements included clinical evaluation for site of allergy, possible precipitating factors, consu...

Hossny Elham; Gad Ghada; Shehab Abeer; El-Haddad Amgad

2011-01-01

251

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The schistosomal parasite plays a critical role in the development of malignant lesions in different organs. The pathogenesis of cancer is currently under intense investigation to identify reliable prognostic indices for disease detection. The objective of this paper is to evaluate certain biochemical parameters as diagnostic tools to efficiently differentiate between colonic carcinoma and colonic carcinoma associated with schistosomal infection among Egyptian patients. The parameters under i...

Manal Abdel Aziz Hamed; Samia Abdel Aziz Ahmed; Hussein Moustafa Khaled

2011-01-01

252

Facial reconstruction of a wrapped Egyptian mummy using MDCT  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVE: Facial reconstruction of mummies and corpses in general is important in anthropological, medical, and forensic studies. The purpose of our study was to evaluate the role of MDCT examination for 3D facial reconstruction and report the results of multidisciplinary work performed by radiologists, anthropologists, and forensic police in reconstructing the possible physiognomy of an ancient Egyptian mummy. MATERIALS AND METHODS: Three-dimensional MDCT data were obtained from a well-pres...

Gandini, Giovanni; Boano, Rosa

2004-01-01

253

Sesame seed sensitization in a group of atopic Egyptian children.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background: There are no published data on the prevalence of sesame allergy/sensitization in Egypt. Objective: In this pilot study, we thought to estimate the frequency of sesame seed sensitization in a group of atopic Egyptian infants and children. Methods: We consecutively enrolled 90 patients with physician diagnosed allergic disease. The study measurements included clinical evaluation for the site and duration of allergy, history suggestive of sesame seed allergy, and family history of al...

2013-01-01

254

Biodiversity of Bacterial Ecosystems in Traditional Egyptian Domiati Cheese?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Bacterial biodiversity occurring in traditional Egyptian soft Domiati cheese was studied by PCR-temporal temperature gel electrophoresis (TTGE) and PCR-denaturing gradient gel electrophoresis (DGGE). Bands were identified using a reference species database (J.-C. Ogier et al., Appl. Environ. Microbiol. 70:5628-5643, 2004); de novo bands having nonidentified migration patterns were identified by DNA sequencing. Results reveal a novel bacterial profile and extensive bacterial biodiversity in Do...

El-baradei, Gaber; Delacroix-buchet, Agne?s; Ogier, Jean-claude

2007-01-01

255

Determinants of Work Relation Perception: Organizational Culture in Egyptian Workplaces  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This study aimed at investigating different types of organizational cultures common in Egyptian workplaces andhow they might be influenced by the type of ownership (governmental, public, or private), the region in whichthe organization exists (Cairo, North Egypt, or South Egypt), and the organization size (large vs. small).Organizational cultures were divided, according to the Competing Values Model proposed Cameron and Quinn(1999/2006), into four types: Market, Hierar...

Mohamed Taha Mohamed

2013-01-01

256

What kind of Arabic and why? Language in Egyptian blogs  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This article strives to set in motion comprehensive research on the ways in which Arabic is evolving in Arabic blogs and computer mediated communication (CMC). By combining media studies, sociolinguistics and literature it examines code choice, content and mode of representation in five top ranked Egyptian blogs. We distinguish between MSA, ECA and mixed varieties and establish that all three codes may be employed. We argue that bloggers make deliberate choices regarding code, and that code-s...

Ramsay, Gail

2013-01-01

257

Sociodemographic factors responsible for blindness in diabetic Egyptian patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Khaled Gamal Ibraheem Abueleinen1, Hany El-Mekawey1, Yasser Sayed Saif2, Amr Khafagy1, Hoda Ibrahim Rizk3, Eman M Eltahlawy41Department of Ophthalmology, Cairo University, Cairo, Egypt; 2Department of Ophthalmology, Beni-Suef University, Beni-Suef, Egypt; 3Department of Public Health, Cairo University, Cairo, Egypt; 4Public Health and Community Medicine National Research Center, Cairo, EgyptPurpose: To evaluate factors behind the delay in diagnosis and treatment among Egyptian patients who pr...

2011-01-01

258

Egyptian Red Sea petroleum geology and regional geophysical evaluation  

Energy Technology Data Exchange (ETDEWEB)

The World Bank-executed Red Sea/Gulf of Aden Regional Hydrocarbon Study Project was organized to synthesize data on the Red Sea and Gulf of Aden basins. The primary objectives were to encourage increased hydrocarbon exploration techniques basin wide, and to train national geoscientists in exploration techniques. The study was carried out be task forces for each participating country, working in Cairo under the supervision of World Bank technical personnel. In addition, biostratigraphic, paleoenvironmental, and lithostratigraphic analyses by Robertson Group and geochemical studies and BEICIP were carried out on well cuttings and core samples. The study of the Egyptian Red Sea was based on public-domain exploration data, published information, and data released by operating companies. This included reports, sections, and wireline logs from 13 well, samples from ten wells for biostratigraphic analysis, and samples from eight wells for geochemical analysis. Interpretation was carried out on 4,350 line-km of seismic data selected from a grid of 19,000 line-km of data. Four horizons were identified on a regional basis, including the sea floor, top, and near base of middle to upper Miocene evaporites, and approximate acoustic basement. The results show that the Egyptian Red Sea is similar to the better known, productive Gulf of Suez in many respects, including overall tectonic evolution and structural style, present geothermal gradients, and Miocene to Holocene stratigraphic sequence. Based in part on this similarity, the Egyptian Red Sea appears to contain the necessary elements for an attractive petroleum potential.

Ahmed, Y.H.; Shalaan, A.A.; Zaki, H.A. (Egyptian General Petroleum Corp., Cairo (Egypt))

1991-08-01

259

Sex identification from fingertip features in Egyptian population.  

Science.gov (United States)

Identification of an individual plays a vital part of any medico-legal investigation. Fingerprints are considered to be one of the most reliable methods of identification. The present study was conducted on 752 healthy adult Egyptian subjects (380 males and 372 females) with age ranged from 20 to 30 years. Consents were obtained from all participants and their 10 digits were photographed to determine the sexual dimorphism by some fingertip features (ridge count, square area, finger breadth and finally ridge density) in Egyptians. Statistical analysis was made using a multivariate logistic regression variation analyses. Results showed that females tend to have statistically significant shorter (narrower) finger breadth (right: male > 9.54 ? female, left: male > 9.38 ? female), smaller square area (right: male ? 16.1 > female, left: male > 15.1 ? female), more ridge count (right: female > 21.0 ? male, left: female > 21.2 ? male), and higher ridge density (right: female >1.35 ? male, left: female > 1.5 ? male) when compared with males. The ridge density of the left hand was the most single accurate parameter in correct sex determination. The best classification accuracy of 82% was generated upon combining ridge count, square area and ridge density. It was concluded that fingertip features of Egyptians can be used by medico-legal experts for accurate sex identification. PMID:23217375

Eshak, Ghada Attia; Zaher, Jaklin Fekri; Hasan, Eman Ismail; El-Azeem Ewis, Ashraf Abd

2013-01-01

260

Mutational spectrum of Xeroderma pigmentosum group A in Egyptian patients.  

Science.gov (United States)

Xeroderma pigmentosum (XP) is a rare autosomal recessive hereditary disease characterized by hyperphotosensitivity, DNA repair defects and a predisposition to skin cancers. The most frequently occurring type worldwide is the XP group A (XPA). There is a close relationship between the clinical features that ranged from severe to mild form and the mutational site in XPA gene. The aim of this study is to carry out the mutational analysis in Egyptian patients with XP-A. This study was carried out on four unrelated Egyptian XP-A families. Clinical features were examined and direct sequencing of the coding region of XPA gene was performed in patients and their parents. Direct sequencing of the whole coding region of the XPA gene revealed the identification of two homozygous nonsense mutations: (c.553C >T; p.(Gln185)) and (c.331G>T; p.(Glu111)), which create premature, stop codon and a homodeletion (c.374delC: p.Thr125Ilefs 15) that leads to frameshift and premature translation termination. We report the identification of one novel XPA gene mutation and two known mutations in four unrelated Egyptian families with Xermoderma pigmentosum. All explored patients presented severe neurological abnormalities and have mutations located in the DNA binding domain. This report gives insight on the mutation spectrum of XP-A in Egypt. This would provide a valuable tool for early diagnosis of this severe disease. PMID:24135642

Amr, Khalda; Messaoud, Olfa; El Darouti, Mohamad; Abdelhak, Sonia; El-Kamah, Ghada

2014-01-01

 
 
 
 
261

Effect of zinc supplementation on serum antibody titers to heat shock protein 27 in patients with thalassemia major.  

Science.gov (United States)

Objective This current study was conducted to determine the effect of zinc supplementation on antibody titers to heat shock protein 27 (anti-HSP27) in patients with beta-thalassemia major (?-TM). Methods This was a double-blinded placebo-controlled clinical trial conducted at Dr Sheikh Hospital (Mashhad, Iran) from 2011 to 2012. Sixty-four patients (41 females and 23 males), aged between 8 and 18 years with transfusion-dependent ?-TM were randomly allocated to two age- and sex-matched groups. The zinc (case) group received 30 mg of daily zinc sulfate supplementation and the placebo (control) group received same shape and color placebo over 9 months period of the trial. Serum anti-HSP27 titers were measured at the third and ninth months of the trial, using an in-house enzyme-linked immune-absorbent assay. Result There was a significant difference in anti-HSP27 titers, between the groups after 9 months. The baseline value of anti-HSP27 was 0.44 ± 0.15 in zinc group and were significantly decreased to 0.40 ± 0.18 after 9 months on treatment, while the baseline value of anti-HSP27 were significantly increased from 0.43 ± 0.17 to 0.44 ± 0.18 in the placebo group (P = 0.01). Conclusion Serum anti-HSP27 titers were significantly reduced in patients with ?-TM treated with zinc supplements compared to a group treated with a placebo. It suggests that the potential antioxidant and anti-inflammatory effects of zinc supplements may account for a reduction in anti-HSP27 titers in patients with ?-TM. PMID:23683800

Ghahramanlu, Elham; Banihashem, Abdollah; Mirhossini, Naghme-Zahra; Hosseini, Golkoo; Mostafavi-Toroghi, Hesam; Tavallaie, Shima; Meshkat, Mojtaba; Ghayour-Mobarhan, Majid; Ferns, Gordon

2014-03-01

262

On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Trials of iron chelator regimens have increased the treatment options for cardiac siderosis in beta-thalassemia major (TM patients. Treatment effects with improved left ventricular (LV ejection fraction (EF have been observed in patients without overt heart failure, but it is unclear whether these changes are clinically meaningful. Methods This retrospective study of a UK database of TM patients modelled the change in EF between serial scans measured by cardiovascular magnetic resonance (CMR to the relative risk (RR of future development of heart failure over 1 year. Patients were divided into 2 strata by baseline LVEF of 56-62% (below normal for TM and 63-70% (lower half of the normal range for TM. Results A total of 315 patients with 754 CMR scans were analyzed. A 1% absolute increase in EF from baseline was associated with a statistically significant reduction in the risk of future development of heart failure for both the lower EF stratum (EF 56-62%, RR 0.818, p Conclusion These data show that during treatment with iron chelators for cardiac siderosis, small increases in LVEF in TM patients are associated with a significantly reduced risk of the development of heart failure. Thus the iron chelator induced improvements in LVEF of 2.6% to 3.1% that have been observed in randomized controlled trials, are associated with risk reductions of 25.5% to 46.4% for the development of heart failure over 12 months, which is clinically meaningful. In cardiac iron overload, heart mitochondrial dysfunction and its relief by iron chelation may underlie the changes in LV function.

Carpenter JP

2011-09-01

263

The Problem of the Pyramid or Egyptian Mathematics from a Postmodern Perspective  

Science.gov (United States)

We consider Egyptian mathematics from a postmodern perspective, by which we mean suspending judgement as to strict correctness in order to appreciate the genuine mathematical insights which they did have in the context in which they were working. In particular we show that the skill which the Egyptians possessed of obtaining the general case from…

Shutler, Paul M. E.

2009-01-01

264

The impact on the Netherlands of the Egyptian greenhouse vegetable chain  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This report forms part of a broader analysis of the competitiveness of Dutch tomatoes, cucumbers and peppers on the European market. It describes elements of Porter's competitiveness analysis for the Egyptian horticultural sector. Within this framework, it presents an analysis of the domestic demand, the supply, the structure and strategy of firms, the network and the Egyptian government. It concludes with a SWOT analysis.

Wijnands, J. H. M.

2004-01-01

265

Higher Education and Some Upper Egyptian Women's Negotiation of Self-Autonomy at Work and Home  

Science.gov (United States)

This research aims to compare the effect of higher education on some Upper Egyptian women's practice of self autonomy at both work and home. The most important revelation this research makes is the fact that although no one can deny the importance and significance of higher education to Upper Egyptian women, yet it failed to challenge the…

El-Halawany, Hanan Salah El-Deen

2009-01-01

266

Interferon therapy shifts natural killer subsets among egyptian patients with chronic hepatitis C  

Directory of Open Access Journals (Sweden)

Full Text Available Natural killer cells can be divided into five subpopulations based on the relative expression of CD16 and CD56 markers. The majority of natural killer cells are CD56dim, which are considered to be the main cytotoxic effectors. A minority of the natural killer cells are CD56bright, and function as an important source of immune-regulatory cytokines. Shifts of these subsets have been reported in patients with chronic hepatitis C virus infection. We sought to investigate the shift of natural killer subsets among Egyptian patients with chronic HCV and to analyze the influence of interferon therapy on this shift. We applied a flow cytometric analysis of peripheral blood natural killer subsets for 12 interferon-untreated and 12 interferon-treated patients with chronic HCV, in comparison to 10 control subjects. Among interferon-untreated patients, there was a significant reduction of CD56-16+ (immature natural killer cells. Among interferon-treated patients, the absolute count of natural killer cells was reduced, with expansion of the CD56bright subset and reduction of the CD56dim16+ subset. Natural killer subset counts were not significantly correlated to HCV viral load and were not significantly different among interferon responders and non-responders. In conclusion, HCV infection in Egyptian patients has been observed to be statistically and significantly associated with reduction of the CD56-16+NK subset, while a statistically significant expansion of CD56bright and reduction of CD56dim16+ subsets were observed after interferon therapy. Further studies are required to delineate the molecular basis of interferon-induced shift of natural killer subsets among patients with HCV.

Amal Fathy

2010-08-01

267

BENCHMARKING THE EGYPTIAN MEDICAL TOURISM SECTOR AGAINST INTERNATIONAL BEST PRACTICES: AN EXPLORATORY STUDY  

Directory of Open Access Journals (Sweden)

Full Text Available This paper argues that any compatible strategy for the development of medical tourism at a developing nation should be based primarily on a comprehensive benchmarking study. It has employed the benchmarking phase of a national project for the development of an Egyptian medical tourism strategy to showcase significance of such benchmarking implications. The benchmarking phase of the Egyptian project has used two main data sets to reach reliable findings: a series of best practice destinations claimed to be key players leading the future of the medical tourism sector worldwide and an extensive survey of the Egyptian medical tourism sector. Arguably, the benchmarking process was crucial for the development of the strategy to measure performance of Egypt’s medical tourism sector against international best practices, to identify gaps in the Egyptian medical tourism sector and to address main areas required to develop ‘service value chain’ for the Egyptian medical tourism sector.

Eman M. Helmy

2011-09-01

268

The impact of vascular risk factors multiplicity on severity of carotid atherosclerosis—A retrospective analysis of 1969 Egyptian subjects  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Purpose: Carotid atherosclerosis has been recognized as a major cause of stroke. The cur-rent study aimed to describe the effect of multiplicity rather than the type of vascular risk factors on severity of carotid atherosclerosis among a large sample of Egyptian population. Methods: We analyzed the data of 1969 Egyptian subjects, who proved to have extra cranial carotid atherosclerotic disease by duplex scanning at the vascular laboratories of Cairo Uni-versity Hospitals. Demographic, clinical data and causes of referral were recorded and correlated with ultrasound findings. Atherosclerotic indices, namely IMT, plaque number and percentage of stenosis were used for evaluation of severity of carotid atherosclerosis. Furthermore, subjects were classified according to multiplicity of major atherosclerotic risk factors and multivariate regression analysis was performed to detect independent predictors of significant carotid disease. Results: Out of 1969 subjects with proved signs of extracranial carotid atherosclerosis by duplex ultrasonographic scan, 225 (11.4% showed hemody-namic significant stenosis (?50%. Multiplicity of risk factors beyond the age of 50 years was the strongest predictor of significant stenosis. Conclusion: Age more than 50 years and multiplicity rather than the type of risk factors were the strongest predictors of significant carotid atherosclerotic disease (CAD.

Essam Baligh

2013-08-01

269

Egypt: A Simulation of Ancient Egyptian Civilization.  

Science.gov (United States)

This simulation allows students to travel north through the six divisions of the Nile River, with each major phase of the simulation called a "cataract". Students earn travel points as they sail the Nile from its source in Central Africa through the Sixth Cataract, all the way to the First Cataract, and then on to the delta where it flows into the…

Sargent, Marcia; Malcolm, Vivian

270

Credibility of measurement of fructosamine and hemoglobin A1C in estimating blood glucose level of diabetic patients with thalassemia major  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Aim: Patients with thalassemia major are classified in high risk group for diabetes mellitus, and therefore monitoring blood glucose level has a vital importance in these people. As high fetal hemoglobin level in thalassemia patients interferes with measurement of glycosylated hemoglobin (hemoglobin A1C, fructosamine evaluation as an alternative approach is suggested.Materials and Methods: This descriptive study was carried out on 33 diabetes mellitus patients with beta-thalassemia (21 female and 12 male cases. The following biochemical measurements were done: blood glucose level through biochemical glucose oxidation method, fructosamine by colorimetry, hemoglobin A1c by immunoturbidimetry, serum ferritin by chemiluminescence and fetal hemoglobin by HPLC methods. Using SPSS software v18.0, statistical analysis was done and correlation between fructosamine and hemoglobin A1c (Pearson’s correlation and linear regression were investigated. p<0.05 was considered as statistically significant.Results: In female and male patients, blood glucose levels were 204±103 mg/dL and 224±101 mg/dL (p=0.63, fetal hemoglobin were 9%±7% and 13%±9% (p=0.22; serum ferritin levels were 1744±1534 ng/mL and 3253±1773 ng/mL (p=0.96, respectively. Mean serum fructosamine level was 442±124 mmol/L and glycosylated hemoglobin amount was 8.9%±1.8%. These two parameters showed significant correlation (r=0.69, p<0.01. Blood glucose level with hemoglobin A1c (r=0.75, p<0.01 and fructosamine (r=0.54, p<0/01 showed a significant correlation.Conclusion: In diabetic patients with thalassemia major who have frequent blood transfusion, evaluation of serum fructosamine and glycosylated hemoglobin levels are both reliable approaches for estimating blood glucose levels and the two methods can be used alternatively.

Mehrnoush Kosaryan

2012-11-01

271

An EPR study on ancient and newly synthesised Egyptian blue.  

Science.gov (United States)

Two sets of ancient Roman Egyptian blue (EB) samples and one set of EB samples synthesised in our lab, were analysed by EPR spectroscopy, a technique not commonly used in this field. The spectroscopic parameters obtained were used to attempt the discrimination of the provenance and of the manufacturing techniques of the investigated samples. The results obtained show that EPR technique could be very useful for this purpose. Furthermore, the similarity of the obtained parameters between the ancient and new samples testify the successful attempt to reproduce the EB according to the chemical knowledge. PMID:18970397

Orsega, Emilio F; Agnoli, F; Mazzocchin, G A

2006-01-15

272

Biochemical key to eight species of adult Egyptian mosquitoes.  

Science.gov (United States)

1. An electrophoretic key is described, based on enzyme relative mobility, to distinguish eight species of Egyptian mosquito adults. 2. Using horizontal starch gel electrophoresis, five different enzyme assays unambiguously separated Culex pipiens L., Cx antennatus (Becker), Cx pusillus Macquart, Aedes caspius (Pallas), Culiseta longiareolata (Macquart), Uranotaenia unguiculata Edwards, Anopheles multicolor Cambouliu and An.pharoensis Theobald. 3. Diagnostic loci between species were: Ak-2, G6pd, alpha-Gpd, Gpi and 6-Pgd; the probability of correct diagnosis in each case was at least 0.989. PMID:1685104

Farid, H A; Gad, A M; Salem, A M; Kashef, A H

1991-04-01

273

Political Unrest Costs Egyptian Tourism Dearly: An Ethnographical Study  

Directory of Open Access Journals (Sweden)

Full Text Available This study uses ethnographical research methodology to observe the negative impact of political unrest on the tourism industry and overall economy of Egypt during the nation’s revolution. In the paper, a number of proactive strategies are suggested to insulate Egypt from future acts of violence. Emphasis on the implementation of a destination management system is also recommended to enhance overall knowledge and efficiency in the Egyptian tourism sector and to help alleviate negative turns in the market caused by regional unrest and political instability.

Mohamed Ahmed Nassar

2012-09-01

274

Intestinal Cryptosporidium sp. infection in the Egyptian tortoise, Testudo kleinmanni.  

Science.gov (United States)

An adult Egyptian tortoise (Testudo kleinmanni) presented with clinical signs of enteritis and died 5 weeks after initiation of antibiotic therapy. Histological examination of the small intestine revealed heavy infection with Cryptosporidium sp.; over 80% of epithelial cells harboured the pathogen. No Cryptosporidium developmental stages were present in the stomach or the lungs. The intestinal lamina propria and mucosa were infiltrated by heterophils, lymphocytes and macrophages. The present study constitutes the first report of Cryptosporidium sp. infection in T. kleinmanni, and the first histological documentation of intestinal cryptosporidiosis in Chelonia. PMID:9925268

Graczyk, T K; Cranfield, M R; Mann, J; Strandberg, J D

1998-12-01

275

Tolerance, Quality and Storability of Gamma-Irradiated Egyptian Rice  

International Nuclear Information System (INIS)

The effect of gamma irradiation on some organoleptic and physico-chemical properties and the storability of Egyptian rice was investigated. Radiation up to 50 krad was chosen as an adequate dose causing non-significant changes in eating and cooking qualities. The effect of irradiation on degradation of starch and protein molecules is demonstrated on the basis of studies on the viscosity and solubility of rice paste. Irradiation at relatively low dose levels up to 50 krad did not affect the chemical and nutritional qualities of rice regarding amino acids and B vitamins. It was also found that irradiation maintains better storability of rice under ambient temperature. (author)

1978-04-01

276

Tolerance, quality and storability of gamma-irradiated Egyptian rice  

International Nuclear Information System (INIS)

The effect of gamma irradiation on some organoleptic and physico-chemical properties and the storability of Egyptian rice was investigated. Radiation up to 50krad was chosen as an adequate dose causing non-significant changes in eating and cooking qualities. The effect of irradiation on degradation of starch and protein molecules is demonstrated on the basis of studies on the viscosity and solubility of rice paste. Irradiation at relatively low dose levels up to 50krad did not affect the chemical and nutritional qualities of rice regarding amino acids and B vitamins. It was also found that irradiation maintains better storability of rice under ambient temperature. (author)

1977-11-25

277

Gamma dose measurements indoor and outdoor of some egyptian buildings  

International Nuclear Information System (INIS)

Some physical parameters affecting the basic dosimetric properties of carbonized aluminum oxide were studied such as Response, Dose recovery, reproducibility, linearity and lower limit of detection. Indoor and Outdoor gamma radiation dose rates were measured inside and outside some Egyptian buildings using Al2 O3-C environmental thermo luminescence dosimeters for 70 days. For these purpose twenty dosimeters of TLD chips were positioned indoor and ten dosimeters were positioned outdoor inside a thin black polythene 30 cm long pipe at one meter above ground as a reference height

2005-04-01

278

Language Maintenance and Transmission: The Case of Egyptian Arabic in Durham, UK  

Directory of Open Access Journals (Sweden)

Full Text Available This sociolinguistic micro-level study examines experiences of five Egyptian families, living in Durham, UK, who are trying to transmit Egyptian Arabic to their children. Answers to the following questions are sought: first, how these language-minority families describe barriers to and supports for passing on Egyptian Arabic to their children? Second, what language decisions they make in order to fulfill their roles? Third, how such decisions are linked to their identity as Egyptians living in an English-dominant country? Finally, what are the factors that helps their children to preserve Egyptian Arabic? The findings, based on data collected through in-depth, semi-structured interviews and participant observation, show that the participants regard Egyptian Arabic as a cultural core value  that is linked with other core values such as religion and identity. Consequently, a number of language-related decisions have been made and implemented to ensure the improvement of their children's Egyptian Arabic spoken proficiency level.

Yasser Ahmed Gomaa

2011-03-01

279

Mitochondrial Mutation In Egyptian Patients With Type 2 Diabetes Mellitus  

Directory of Open Access Journals (Sweden)

Full Text Available Mitochondrial gene mutation plays a role in the development of diabetes mellitus. An A to G substitution at base pair 3243 in the mitochondrial tRNAleu(UUR gene (mt3243 is commonly associated with maternally inherited diabetes and deafness and other diseases. The aim of this study is to detect A to G substitution at base pair 3243 in mitochondrial RNAleu(UUR in the plasma of patients with type 2 diabetes mellitus, and to evaluate insulin sensitivity in all cases. This study, included 41 patients (Group I, 31 cases with type 2 diabetes mellitus and maternal history of diabetes mellitus-and Group II, 10 cases with type 2 diabetes mellitus, bilateral SNHL, maternal history of diabetes mellitus with or without SNHL. Other10 healthy control group was included. Patients and controls were subjected to full medical history and clinical examination. Serum measurements for liver and kidney function tests, fasting and postprandial blood glucose as well as C-peptide levels, in addition to lipid profile were collected. Audiological evaluation for all patients with SNHL was also done. Genetic investigation, for mDNA analysis, done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP, to determine the mutation in the mitochondrial gene at position 3243. Results of the study showed that glycemic indices (FPG, 2hPPG and HbA1c, liver enzymes and blood urea were significantly higher among patient group compared to control group (P<0.05. There was no significant difference for values of creatinine and uric acid between cases and controls. Lipid profile was significantly higher among patient group compared to controls (P<0.05, except for HDL-C which was higher in controls however, it did not reach statistical significance. C-peptide values were not significantly different between studied groups. Age at onset of diabetes was relatively earlier in group II than group I. mDNA was present in all plasma samples of patients and controls. mDNA 3243 mutation was detected in the plasma of three patients with diabetes and SNHL with a rate of 7.3% of all diabetic patients and 30% of diabetic patients associated with deafness. The presence of mDNA mutation allowed 294 bp product to be cleaved into 180 and 114 bp fragments and were seen as two bands. In CoclusioN: The A 3243 G mutation is present in Egyptian population and is considered as a cause of maternally inherited diabetes and deafness at a rate of 7.3% of all diabetic subjects and a rate of 30% of diabetics associated with deafness. mDNA mutation is present and detectable in plasma. Maternally inherited diabetes and deafness differs pathophysiologically from the more common forms of type 2 diabetes in that, insulin resistance does not seem to be a major factor.

Fawzi O,A*; Hassan Z,A*; Abdel Kawy S,I**; Al-Diwany O,I**; Adel

2006-06-01

280

Evaluation of the level of knowledge of Egyptian women of breast cancer and its risk factors. A cross sectional study.  

Science.gov (United States)

Breast cancer is considered the leading cause of cancer death among females in economically developing countries. Prevalence of breast carcinoma is high in Egypt and the cases of breast cancer constitute 29% of cancer cases treated at the national cancer institute. This study aimed at exploring the level of knowledge of Egyptian females of breast cancer and its risk factors. An interview questionnaire with 22 questions about breast cancer was developed. This questionnaire was previously published as a part of the German multicentre DACH study). A total of 600 female subjects that attended primary health care centres were enrolled in our study. The majority were located in Cairo with the mean age of 40.5 +/- 11.0. Most of our studied sample (94%) has heard about breast cancer as a disease. TV and radio were the main sources of knowledge about the disease (60%). The level of knowledge about breast cancer was limited in 80% of the subjects. Younger age subjects had a higher level of knowledge about breast cancer compared to older subjects with no significant difference statistically. The grade of knowledge about breast cancer was higher among highly educated subjects compared to less educated subjects with significant difference statistically. The highest known risk factors of breast cancer were exposure to X ray (79.5%), hormonal therapy (75.7%) and previous breast cancer disease (70.8%). This study clearly illustrates the need for a health education program directed to Egyptian females to improve the knowledge of breast cancer. PMID:23469587

Allam, M F; Abd Elaziz, K M

2012-12-01

 
 
 
 
281

Evidence of Increased Hemolysis after Open Heart Surgery in Patients Heterozygous for Beta-Thalassemia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

To investigate hemolysis after open heart surgery in patients with and without the ?-thalassemia trait, we prospectively studied 85 patients who underwent open heart surgery for various pathologic conditions. Hemoglobin electrophoresis showed that 20 of these patients had the ?-thalassemia trait, whereas the other 65 were normal. To compare the degree of postoperative hemolysis in both groups, we evaluated the serum bilirubin, lactic dehydrogenase, haptoglobin, and plasma hemoglobin levels ...

1988-01-01

282

Health related quality of life in Middle Eastern children with beta-thalassemia  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Thalassemia is a common disorder worldwide with a predominant incidence in Mediterranean countries, North Africa, the Middle East, India, Central Asia, and Southeast Asia. Whilst substantial progress has been made towards the improvement of Health related quality of life (HRQoL in western countries, scarce evidence-based data exists on HRQol of thalassemia children and adolescents living in developing countries. Methods We studied 60 thalassemia children from Middle Eastern countries with a median age of 10?years (range 5 to 17?years. HRQoL was assessed with the Pediatric Quality of Life Inventory (PedsQL 4.0. The Questionnaire was completed at baseline by all patients and their parents. The agreement between child-self and parent-proxy HRQoL reports and the relationship between HRQoL profiles and socio-demographic and clinical factors were investigated. Results The scores of parents were generally lower than those of their children for Emotional Functioning (mean 75 vs 85; p?=?0.002, Psychosocial Health Summary (mean 70.3 vs 79.1; p?=?0.015 and the Total Summary Score (mean 74.3 vs 77.7 p?=?0.047. HRQoL was not associated with ferritin levels, hepatomegaly or frequency of transfusions or iron chelation therapy. Multivariate analysis showed that a delayed start of iron chelation had a negative impact on total PedsQL scores of both children (p?=?0.046 and their parents (p?=?0.007. Conclusions The PedsQL 4.0 is a useful tool for the measurement of HRQoL in pediatric thalassemia patients. This study shows that delayed start of iron chelation has a negative impact on children’s HRQoL.

Caocci Giovanni

2012-06-01

283

the characterization of exon-1 mutation(s) of beta globin gene in beta thalassemia  

International Nuclear Information System (INIS)

?-thalassemia constitutes one of the most serious health problems worldwide, it is the most common chronic hemolytic anemia in egypt. the aim of this work is to study the mutations of exon-1 of ?-globin gene in ?-thalassaemic children in sharkia governorate. the present study was included 25 healthy children and 50 patients diagnosed as ?-thalassemia. this work showed that the thalassaemic patients had significantly decrease in Hb conc . than the control group (p 2 showed a significant increase as compared with the control group

2004-01-01

284

Macrophages support pathological erythropoiesis in Polycythemia Vera and Beta-Thalassemia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Regulation of erythropoiesis is achieved by integration of distinct signals. Among these, macrophages are emerging as erythropoietin-complementary regulators of erythroid development, particularly under stress conditions. We investigated the contribution of macrophages for physiological and pathological conditions of enhanced erythropoiesis. We utilized mouse models of induced anemia, Polycythemia vera and ?-thalassemia in which macrophages were chemically depleted. Our data indicate that ma...

Ramos, Pedro; Casu, Carla; Gardenghi, Sara; Breda, Laura; Crielaard, Bart J.; Guy, Ella; Marongiu, Maria Franca; Gupta, Ritama; Levine, Ross L.; Abdel-wahab, Omar; Ebert, Benjamin L.; Rooijen, Nico; Ghaffari, Saghi; Grady, Robert W.; Giardina, Patricia J.

2013-01-01

285

Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia  

Directory of Open Access Journals (Sweden)

Full Text Available Lorenzo Capretto1, Stefania Mazzitelli2, Eleonora Brognara2, Ilaria Lampronti2, Dario Carugo1, Martyn Hill1, Xunli Zhang1, Roberto Gambari2, Claudio Nastruzzi31Engineering Sciences, University of Southampton, Southampton, UK; 2Department of Biochemistry and Molecular Biology, 3Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, ItalyAbstract: This report shows that the DNA-binding drug, mithramycin, can be efficiently encapsulated in polymeric micelles (PM-MTH, based on Pluronic® block copolymers, by a new microfluidic approach. The effect of different production parameters has been investigated for their effect on PM-MTH characteristics. The compared analysis of PM-MTH produced by microfluidic and conventional bulk mixing procedures revealed that microfluidics provides a useful platform for the production of PM-MTH with improved controllability, reproducibility, smaller size, and polydispersity. Finally, an investigation of the effects of PM-MTH, produced by microfluidic and conventional bulk mixing procedures, on the erythroid differentiation of both human erythroleukemia and human erythroid precursor cells is reported. It is demonstrated that PM-MTH exhibited a slightly lower toxicity and more pronounced differentiative activity when compared to the free drug. In addition, PM-MTH were able to upregulate preferentially ?-globin messenger ribonucleic acid production and to increase fetal hemoglobin (HbF accumulation, the percentage of HbF-containing cells, and their HbF content without stimulating ?-globin gene expression, which is responsible for the clinical symptoms of ß-thalassemia. These results represent an important first step toward a potential clinical application, since an increase in HbF could alleviate the symptoms underlying ß-thalassemia and sickle cell anemia. In conclusion, this report suggests that PM-MTH produced by microfluidic approach warrants further evaluation as a potential therapeutic protocol for ß-thalassemia.Keywords: microfluidics, lab-on-a-chip, design of experiments, erythroid differentiation, human erythroid precursor cells

Capretto L

2012-01-01

286

??????: Leishmania major  

Full Text Available Protozoa Trypanosomatidae Leishmania major Leishmania (Leishmania ) major (synonym) NCBI 5664 Leishmania shmania major (scientific name) NCBI 5664 Leishmania tropica major (synonym) NCBI 5664

287

??????: Flectobacillus major  

Full Text Available Bacteria Flexibacteraceae Flectobacillus major Flectobacillus major (species (AL)) DSMZ 776283 M icrocyclus major Gromov 1963 (authority) NCBI 103 Flectobacillus major (scientific name) NCBI 103 Flectobacillus ma

288

Chemical composition of water hyacinth (Eichhronia Crassipes) a comparison indication of heavy metal pollution in egyptian water bodies. Vol. 4  

International Nuclear Information System (INIS)

Water hyacinth is tested as an indicator for pollution in egyptian fresh surface waters. Chemical composition of water hyacinth as affected area of collection (water bodies) was studied and the suitability of this plant as a biological indicator for water pollution is discussed. Water hyacinth samples were collected three times per year for two years (1991-1993). Sample sites include one location in the river nile (at Helwan area), one site in Ismaillia canal, (at Mostrod industrial area), and one site in Abo-Zabal drain (at Abo-Zabal city). The concentration of 19 major major and trace elements in plant samples were determined by prompt gamma-ray neutron activation analysis. Results indicated that plant parts as well as location have a significant effect on elements content. Water hyacinth roots showed high affinity for accumulation of trace elements. 5 tabs

1996-03-01

289

Environmental education in an Egyptian university: The role of teacher educators  

Science.gov (United States)

Drawing on a holistic critical paradigm of ecological sustainability, this study examined the role of teacher educators in environmental education in the Faculty of Education of one Egyptian university. The study sought to critically and collaboratively explore with a sample of six teacher educators their answers, perceptions and perspectives in relation to their knowledge and understanding of environmental problems in local/global contexts and their meanings of curriculum and pedagogical practices for fostering environmental education in their teacher education programs. The participants generally demonstrated a considerable amount of knowledge of the environmental realities and problems facing Egypt encompassing air, water and solid waste sectors. Their views concurred with national and official studies identifying these issues as the most pressing environmental problems in the country. The exploration of the institutional, social and cultural causes and developmental and/or global causes of environmental problems in Egypt led us to articulate different themes relating environmental crisis in Egypt to different issues. These issues included poverty, education, religion and development. One of the major findings of the study was the participants' view that development was the major contributor to the environmental crisis in Egypt. They all stressed that, in its pursuit of economic growth, the government did not pay due attention to the environmental costs. Sharing perspectives from a critical paradigm of ecological sustainability, the participants felt that the government needed to clearly address the economic and ecological dimensions of development. In addition, a few participants affirmed that development is the thread that ties all the different factors together bringing into the conversations other dimensions of development like the social, values, and political dimensions. Addressing the future dimension of development, all of them expressed the need for a development model that takes into consideration ecological as well as human well-being concerns. The study also presented an overview of the participants' own definitions for environmental education based on their beliefs and emerging from their practices. It also explored the content and pedagogy of environmental education within the Faculty as well as the participants' own practices and reports on the action research phase of the study. The participants agreed that the environment needs to be viewed holistically that includes human beings in relation to each other as well as to other beings and their surroundings. While they all praised the role of educators, they also acknowledged the force of substantive challenges for promoting a critical paradigm of environmental education within the faculty as well as in the whole education system and Egyptian society in general. A major finding of the study was that the situation of environmental education in Egyptian universities need closer and immediate attention, and much work remains to transform education and adopt a framework that would integrate environmental education into the core of the educational programs of the faculty. (Abstract shortened by UMI.)

Goueli, Solafa

290

Androgen receptor-CAG repeats in infertile Egyptian men.  

Science.gov (United States)

This study aimed to assess the androgen receptor (AR) codon amino acids glutamine (CAG) repeats in 185 Egyptian men divided into fertile controls (n = 30), oligoasthenoteratozoospermic (OAT) men (n = 35), nonobstructive azoospermic (NOA) men (n = 120; 18 successful testicular sperm extraction (TESE) and 102 unsuccessful TESE cases). They were subjected to history taking, genital examination, semen analysis, testicular biopsies for NOA cases, serum hormones and CAG repeats by PCR. The mean AR-CAG repeats showed significant difference between NOA group compared with fertile controls or OAT groups. Nonsignificant difference was elicited between OAT group and fertile controls. In NOA cases, CAG repeats demonstrated nonsignificant difference between unsuccessful and successful TESE. AR-CAG repeats elicited significant negative correlation with sperm count, significant positive correlation with sperm normal forms percentage and nonsignificant correlations with sperm motility per cent, tested serum hormones or testicular volume. It is concluded that AR-CAG repeats in Egyptian infertile men are in the range of other international or regional studies. AR-CAG repeats have demonstrated nonsignificant difference regarding TESE outcome in NOA cases. PMID:21714804

Mostafa, T; El-Shahid, L H; El Azeem, A A; Shaker, O; Gomaa, H; Abd El Hamid, H M

2012-06-01

291

Determination of Wax Content in Egyptian Crude Oils  

Directory of Open Access Journals (Sweden)

Full Text Available Wax precipitation is one of the most important flow assurance problems. Unfortunately, experimental data are very scarce to confirm existing models for prediction of such production impairment and other hazardous risk; while its curative approaches and production losses add to colossal economic sabotage to the petroleum industry. The present work deals with studying the determination of wax in Egyptian crude oil by gravimetric determination precipitation with lowering temperature of the crude oil .The crude oil studied was from Egyptian western desert (waxy paraffinic crude. Waxes may precipitate due to a temperature decrease because their solubility is so low that a solid phase can appear. The experiments investigated the effect of initial weight of the crude, the time of cooling, and the temperature on the amount of wax produced. The highest amount of wax was produced with 150gm of the crude oil, at temperature of 0oC and this was done within two hours of the time of experiment. Finally the effect of using solvent on the amount wax content was also studied and it was found that the ratio (3:1 of solvent mixture increases achievement of the maximum amount of wax produced.

Prof.Dr.Ramadan Abu El-Ella

2014-02-01

292

Antidiabetic effects of a standardized Egyptian rice bran extract.  

Science.gov (United States)

An extract was prepared from Egyptian stabilized rice bran and standardized to contain 2% ?-oryzanol in addition to its content of other bioactives, notably tocotrienol and policosanol. The standardized extract was found to have a concentration-dependent effect on insulin release in vitro, which, however, is not mediated by ?-tocotrienol in rice bran (detected by HPLC) as could have been expected. Policosanol and ?-oryzanol have insulinotropic effects. The in vitro data of rice bran directly translate into in vivo data of rats by using a glucose tolerance test (increase in plasma insulin). Tocotrienols are well known for their apoptotic effect on tumor cells; nevertheless, an attempt was made to study glucose uptake in HEP-G2 cells, which needs to induce an insulin-resistant state by TNF-?. The Egyptian rice bran extract has an antidiabetic effect. ?-Oryzanol, which is a possible precursor of the insulinotropic compound ferulic acid, is a candidate for this effect. Therefore, it is reasonable to assume that the prevalence of diabetes or at least a prediabetic (type 2) situation can be ameliorated by the investigated rice bran extract. The potential usefulness of the extract as a nutraceutical is currently undergoing more thorough investigations. PMID:22566008

Kaup, Rebecca M; Khayyal, Mohamed T; Verspohl, Eugen J

2013-02-01

293

Chemical Evaluation of Irradiated Egyptian Truffles  

International Nuclear Information System (INIS)

The main objective of this study is to investigate and evaluate the chemical compositions of irradiated and non-irradiated truffles (Al-Kamah)as a natural product for human nutrition with concentrated high value protein supplementation. White and brown truffles grow in Egypt and White truffle is identified as Tirmania nivea and brown truffle is identified as Terfezia budiari. Field survey for four truffle seasons including the best habit for production in Sidi Barani and Salum. Chemical composition of fresh and stored truffles indicated some differences between the two studied species. It was found that the white truffle had higher contents of carbohydrate and fat (45.5% and 7.2%), thenbrown truffle (47.5% and 7.5%)respectively, while the browntruffle had the higher contents of proteins, fiber and ash (23.8%, 8%, and 14%) than the white (22.8, 7.5 and 8% resp.). Cysteine was the highest amino acid in white truffle, while isoleucine was the highest one in brown truffle. The major fatty acids appeared in white and brown truffles were linoleic (46 and 28.3%) and Oleic (37.5 and 6209%) of total fatty acids. B-sitosterol was the major sterol in white truffle while stigmasterol in brown truffle (3.4% and 42.6%). The phytochemical screening revealed that numerous compounds are present as saponins, alkaloids, nitrogen bases,sterols, triterpenes and glycosides. The effect of irradiation (2 K Gy) was limited on bio-component. On the other hand, the biochemical components were investigated in irradiated truffle as a method for preservation. Some changes were observed during storage for 2 months. These chages affect the nutrition value of truffle

2005-01-01

294

Planning closure safety assessment for the Egyptian near surface disposal facility  

International Nuclear Information System (INIS)

The development of a repository is a significant national effort requiring several decades to complete, as well as a substantial amount of skilled human, economical and technical resources. Planning and implementation of different disposal activities proceed in a stepwise manner, guided by decision points. Granting license is considered one of the major decision points that require the presentation of a safety case to evaluate the acceptability of the repository practice. The Egyptian regulation requiring the conduction of safety assessment studies as an essential requirement in license application for construction, operation, and closure of a near surface disposal. Closure of a disposal facility is the last major operational step in completing the disposal system. It requires the consideration of a combination of scientific, engineering, regulatory, and socio-economic factors that are integrated and optimized to select cost-effective alternatives acceptable to all interested parties. In this work, a general framework will be established to conduct a safety assessment methodology for closure of near surface disposal. (author)

2005-10-03

295

Prevalence of thyroid dysfunction in Egyptian chronic hepatitis C patients treated with Pegylated interferon and Ribavirin  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Hepatitis C is a major cause of liver-related morbidity and mortality and represents a major public health problem in Egypt and worldwide. INF therapy is the most popular treatment for HCV. INF has many side effects most of them still under study. The development of thyroid dysfunction during IFN and Ribavirin combination therapy has been reported. Aim: The aim of this study is to assess the Prevalence of thyroid dysfunction in Egyptian chronic hepatitis C patient treated with pegylated interferon and Ribavirin Materials & Methods: The study was conducted in cooperation between Internal Medicine Department, Faculty of Medicine, Cairo University and Internal Medicine Department, out patients' clinic of National Hepatology and Tropical Medicine Research Institute (NHTMRI in the period from January 2009 to June 2010. The current study included 200 patients who fulfilled the predesigned inclusion criteria. TSH was done pre treatment, every 3 months during treatment and 3 months following termination of treatment also were done for all cases. Also, FT3 and FT4 were done if there is abnormal TSH. Results: The prevalence of thyroid dysfunction in chronic hepatitis C patients treated with pegylated INF and Ribavirin reaching 19% in this study.

Sherif M. Naguib1, Ahmed M.Hashem1, Radi Hammad2,Mohamad A.Hassanein3,Niveen

2011-04-01

296

Purification of rare earth oxides from a concentrate obtained during the processing of Egyptian monazite  

International Nuclear Information System (INIS)

Full text: The possibility of purification of the rare earth concentrate produced of Egyptian monazite processing was investigated. The precipitation of hydroxides and oxalates gave rare earth oxide mixtures with a rare earth content about 99.0%

1998-10-25

297

Frequency of Autogeny in Wild-Caught Egyptian Phlebotomus Papatasi (Scopoli) (Diptera:Psychodidae).  

Science.gov (United States)

The high autogenous percentage of Egyptian Phlebotomus (P.) papatasi suggests an ability to maintain the population without a blood source. The unpublished studies have established that autogenous generations produce few eggs and fewer F1 to F6 progeny th...

K. M. El Kammah

1972-01-01

298

Detection and partial characterization of herpesviruses from Egyptian tortoises (Testudo kleinmanni) imported into Italy from Libya.  

Science.gov (United States)

A group of approximately 370 Egyptian tortoises (Testudo kleinmanni) and 36 spur-thighed tortoises (Testudo graeca) were illegally imported into Italy from Libya. Within 6 mo of their entry into Italy, all but 40 of the Egyptian tortoises had died with signs of severe stomatitis. Herpesviruses were detected from the tongues of seven Egyptian tortoises by polymerase chain reaction (PCR) and virus isolation. Sequencing of a portion of the UL39 homologue of the herpesviruses from three different tortoises demonstrated that the viruses were identical to one another and identical to a herpesvirus isolated from a Hermann's tortoise (Testudo hermanni) in Germany. This is the first description of the detection of a herpesvirus from diseased Egyptian tortoises. That these animals were imported into Europe from Libya provides circumstantial evidence for the presence of herpesviruses among tortoises in northern Africa. PMID:19368266

Marschang, Rachel E; Papp, Tibor; Ferretti, Luigi; Hochscheid, Sandra; Bentivegna, Flegra

2009-03-01

299

The future of the independent Egyptian music in the digital era  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This thesis is investigating the impact of the digital era with its technological advanced components and revolutionized information platforms on shaping the future of the independent Egyptian music. The author investigated this impact through conducting fifteen semi structured qualitative interviews between the 15th of December 2012 to 25th of January 2013 with the relevant Independent Egyptian Music stakeholders who gave the researcher a better insight of what is the optimal business model(...

Maraghah, Mohammad

2013-01-01

300

Effect of Different Dietary Levels of Egyptian Clover on Broiler Performance  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This study was planned to investigate the optimum level of Egyptian clover, as a supplementary protein source in broiler ration. Five experimental rations having 0, 2, 4, 6, & 8 percent sun-cured Egyptian clover were fed to 250 broiler chicks. A pre-experimental period of 5 days was followed by 35 days of experimental period. Average weight gain, feed consumption, feed efficiency, dressing percentage, cost of feed per unit weight gain and mortality were used as criteria of response. The mean ...

Muhammad Arif; Mushtaq Ahmed; Fazli Raziq Durrani

2000-01-01

 
 
 
 
301

Isolation and Characterization of Highly Potent Mosquitocidal Bacilli from Egyptian Environment  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A number of 359 Bacilli isolates were obtained from soil samples collected from different Egyptian governorates. Five Egyptian isolates identified as Lysinibacillus sphaericus yielded highly potent mosquitocidal toxicity. These isolates (Ls 9B24, Ls 3B3, Ls 2LB10, Ls 4N9 and Ls 4LB19) were obtained from soils of Alexandria, Kafr El- Sheikh, New valley and El- Gharbeya governorates respectively. The values of LC50 and LC90 of these isolates showed that the most act...

Foda, Mohamed S.; Amin, Magdi A.; El-tayeb, Osama M.; Gawdat, Noha A.; El-bendary, Magda A.

2013-01-01

302

Cultivation and subgroup determination of human rotaviruses from Egyptian infants and young children.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Primary African green monkey kidney cells were more sensitive than primary cynomolgus monkey kidney and MA104 cells for supporting the growth of human rotaviruses detected in diarrheal stools of Egyptian infants and young children. In attempts to characterize these Egyptian rotaviruses, only 31% of the strains tested in the form of fecal suspensions were identified as subgroup 1 or 2. After one passage in African green monkey kidney cells, 80% of the strains were identified as subgroup 1 or 2...

1984-01-01

303

Prune belly syndrome in an Egyptian infant with Down syndrome: A case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Introduction Prune belly syndrome is a rare congenital anomaly of uncertain aetiology almost exclusive to males. The association between prune belly syndrome and Down syndrome is very rare. Case presentation A 4-month-old Egyptian boy was admitted to our institute for management of acute bronchiolitis. He was born at full term by normal vaginal delivery. His mother, a 42-year-Egyptian villager with six other children, had no antenatal or prenatal care. ...

2008-01-01

304

The impact of organizational characteristics on AMT adoption: A study of Egyptian manufacturers  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Purpose - This research seeks to empirically explore and examine the impact of organizational characteristics, i.e. firm size, type of production system, organizational design and type of ownership, on advanced manufacturing technology (AMTs) adoption in the Egyptian industrial sector; and to identify the similarities and dissimilarities of the nature of AMT adoption in Egypt compared to different contexts. Design/methodology/approach - The analysis was based on a survey of 200 Egyptian manuf...

Salaheldin, S. I.

2007-01-01

305

Comparative Study between Yemini and Egyptian types of honey by means of antibacterial activity  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Six samples of Yemeni and Egyptian types of bee honey were chemically analyzed using different chemical standard methods. Yemeni honey types were Dhaba, Samer and Merbeiy while Egyptian types were Citrus, Cotton and Clover. The antibacterial activity of these types of honey was examined using the original samples as well as the samples after heating at 50 and 100 ° C for 30 minutes against pathogenic bacteria. The tested bacteria were Proteus sp, Shigella sp, E. coli, Listeria monocytogenes ...

El-Fadaly; Abdilla, F. S.; El-badrawy, E. E. Y.

1999-01-01

306

Nitrogenase Activity of Pseudomonas corrugata Isolated from Egyptian Lettuce  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In the present study an isolate capable of root colonization of Egyptian Lettuce was isolated from the roots after selective enrichment. The isolated strain was identified as Pseudomonas corrugata by using Biochemical and Biolog identification system. The isolate has been found to be positive for nitrogenase activity. This root-colonized bacterium has not been previously isolated from Egyptian Lettuce and could be used as a bio-fertilizer.

Abada, Emad A.

2006-01-01

307

Rise of the Israelo-Egyptian cooperation for energy. Essor de la cooperation energetique Israelo-Egyptienne  

Energy Technology Data Exchange (ETDEWEB)

Cooperation between Israel and Egyptian Arab Republic relative to the petroleum trade spreads out. The most important project is about a joint venture to build in three years a petroleum refinery able to treat 100 000 barrels by day of egyptian heavy crude oil and light petroleum coming from Golf countries. This refinery would be in the area of Ameriya. An other Israelo-Egyptian project of refinery at Port-Said is under negotiations. Israel signed an Egyptian natural gas purchasing contract and then an agreement to build a gas pipeline to convey this natural gas.

Blin, L.

1994-03-16

308

Longitudinal Study on Liver Functions in Patients with Thalassemia Major before and after Deferasirox (DFX) Therapy  

Science.gov (United States)

By performing regular blood transfusion and iron chelation therapy, most patients with beta thalassemia major (BTM) now survive beyond the third decade of life. Liver disease is becoming an important cause of morbidity and mortality in these patients. Chronic hepatitis and/or severe iron overload are both important causes of liver pathology. Iron chelation with desferrioxamine (DFO) reduces excessive body iron, but its efficacy is limited by poor compliance and dose related toxicity. The recent use of Deferasirox ( DFX ), an oral single dose therapy, has improved the compliance to chelation. Aims To study the long-term liver functions in BMT patients, seronegative for liver infections before versus after DFX treatment in relation to ferritin level. Methods Only BTM patients with hepatitis negative screening (checked every year) and on treatment with DFO for at least five years and with DFX for four years were enrolled. Liver function tests including serum bilirubin, alanine transferase (ALT), aspartate transferase (AST), albumin, insulin-like growth factor – I (IGF-I) and serum ferritin concentrations were followed every six months in 40 patients with BTM. Results DFX treatment (20 mg/kg/day) significantly decreased serum ferritin level in patients with BTM; this was associated with a significant decrease in serum ALT, AST, ALP and increase in IGF-I concentrations. Albumin concentrations did not change after DFX treatment. ALT and AST levels were correlated significantly with serum ferritin concentrations ( r = 0.45 and 0.33 respectively, p < 0.05). IGF-I concentrations were correlated significantly with serum ALT (r= 0.26, p = 0.05) but not with AST, ALP, bilirubin or albumin levels. The negative correlation between serum ferritin concentrations and ALT suggests that the impairment of hepatic function negatively affect IGF-I synthesis in these patients due to iron toxicity, even in the absence of hepatitis. Conclusions Some impairment of liver function can occur in hepatitis negative thalassemic patients with iron overload. The use of DFX was associated with mild but significant reduction of ALT, AST and ALP and increase in IGF-I levels. The negative correlation between IGF-I and ALT concentrations suggest that preventing hepatic dysfunction may improve the growth potential in these patients.

Soliman, Ashraf; Yassin, Mohamed; Al Yafei, Fawzia; Al-Naimi, Lolwa; Almarri, Noora; Sabt, Aml; De Sanctis, Vincenzo

2014-01-01

309

Synchrotron radiation analysis on ancient Egyptian vitreous materials  

International Nuclear Information System (INIS)

Ancient Egyptian vitreous materials, namely faience and glass, share the same elemental composition. But they appear to have originated separately. Faience objects appear as early as the Predynastic period, and glass was introduced from Mesopotamia during the New Kingdom. These faience and glass objects were not of daily use, rather they were regarded as religious symbols or luxury status goods. Most of the products were coloured blue, but we see an increased use of other colours during the New Kingdom (c.1550-1069BC). This tendency corresponds to the period of both territorial and political expansion of Egypt. A non-destructive SR-XRF experiment at SPring-8 was conducted last winter, aiming to determine the regional trait of elemental composition by examining the pattern and ratio of rare earth elements. As a result, we could observe some distinctive rare earth elements that may indicate regional variation. (author)

2000-07-12

310

Characterization of Gamma-Irradiated Egyptian Wheat Flour  

International Nuclear Information System (INIS)

Physical, rheological and baking properties of bread Shamy, prepared from gamma-irradiated Egyptian wheat flour up to 25 KGy as one of common types of bread in Egypt, were studied and the acceptability of bread was evaluated by sensory tests. All amylo-, farino-, and extensograph characteristics and also sample ph showed significant decrease as irradiation dose increased. Such results could be explained in terms of loss of unique elastic and cohesive properties of wheat gluten and starch damage upon increment of radiation dose. The improvement in properties of bread, baked from flour irradiated up to 7.5 KGy, could be explained on the basis of a simulation in gas production during dough fermentation due to increase in starch degradation products. However, bread, prepared from wheat samples irradiated above 7.5 KGy, exhibited significantly lower values of acceptance because of physico-chemical changes in both starch and gluten

2007-04-22

311

LAMQS analysis applied to ancient Egyptian bronze coins  

International Nuclear Information System (INIS)

Some Egyptian bronze coins, dated VI-VII sec A.D. are analyzed through different physical techniques in order to compare their composition and morphology and to identify their origin and the type of manufacture. The investigations have been performed by using micro-invasive analysis, such as Laser Ablation and Mass Quadrupole Spectrometry (LAMQS), X-ray Fluorescence (XRF), Laser Induced Breakdown Spectroscopy (LIBS), Electronic (SEM) and Optical Microscopy, Surface Profile Analysis (SPA) and density measurements. Results indicate that the coins have a similar bulk composition but significant differences have been evidenced due to different constituents of the patina, bulk alloy composition, isotopic ratios, density and surface morphology. The results are in agreement with the archaeological expectations, indicating that the coins have been produced in two different Egypt sites: Alexandria and Antinoupolis. A group of fake coins produced in Alexandria in the same historical period is also identified.

2010-05-15

312

Fallout Radioactivity in Some Egyptian Lakes Bottom Sediments  

International Nuclear Information System (INIS)

As a part of the Egyptian environmental radioactivity monitoring program, the fallout radioactivity levels in Qarun, Bardawill and Ed ku lakes bottom sediments have been measured. The specific activities of "1"3"7Cs were measured using gamma ray spectrometer based on Hyper pure germanium detector. The specific activities of plutonium isotopes("2"3"8Pu, "2"3"9"+"2"4"0Pu and "2"4"1Pu) were measured using alpha spectrometry based on surface battier detectors and liquid scintillation spectrometry after radiochemical separation. The activity ratios "2"3"9"+"2"4"0Pu/"1"3"7Cs, "2"3"9"+"2"4"0Pu/"2"4"1Pu, and "2"3"8Pu/ "2"3"9"+"2"4"0Pu were calculated. The results seemed to confirm that fallout radioactivity is mainly due to nuclear weapons testing fallout

1998-12-12

313

Does Facebook Matter in Egyptian Graduate Environment? A Marketing Perspective  

Directory of Open Access Journals (Sweden)

Full Text Available The current study is exploratory, and it aims at uncovering the potential role of Facebook in Egyptian university environment. The research based on 127 questionnaires. It was found that; 42% of the respondents use Facebook for educational purpose; around 85% use Facebook to be in touch with their teachers; more than 75% use Facebook to contact the faculty administration; more than 70% of students are convinced that they have added value when using Facebook in the educational context. These results would support the notion of using Facebook as an untraditional, cheap, interactive means to enhance the quality of the educational service that provided by the college (producer and received by the student (customer. Implications were presented and suggestion for further studies was highlighted.

Ahmad Yahia Ebeid

2012-05-01

314

HOW EGYPTIAN CONTRACTING COMPANIES TRANSLATE PROJECTS' QUALITY TO PROJECTS' PERFORMANCE  

Directory of Open Access Journals (Sweden)

Full Text Available A model for continuous quality improvement for Egyptian contracting projects’ (CQIM is developed through the extensive reviewing of the Total Quality Management (TQM, Continuous Quality Improvement (CQIliterature, preceding researches, consensus opinions of managers and experts of the construction industry and the quality management system (ISO 9000. This model comprises of 13 main factors divided into 9 CQI constructs and 4 Indices, the Indices are broken down to 46 practical measures, while the CQI constructs are further divided into 58 sub-factors consisting of 231 practical requirements, all targeting the evaluation and improvement of the overall project performance (OPP . This model assists its users to assess their points of weaknesses and strengths, by setting-up a road map for improvement, utilizing a guided framework. This model is used as a benchmarking tool to achieve the goal of this research “Projects' Continuous Quality Improvement”.

Said SHAWKY HOZIEN

2011-07-01

315

Genetic Variation Among Egyptian Cultivars of Vicia faba L.  

Directory of Open Access Journals (Sweden)

Full Text Available Nine Egyptian cultivars of Vicia faba were analyzed using electrophoretic and quantitative data from seed albumins and globulins and 100 seeds weight to measure genetic variation among faba bean cultivars in Egypt. Wide genetic variation was indicated for all the traits studied. The elctrophoregrams showed identity profile for each cutivar supporting the validity of electrophoresis of seed protein components in cultivar identification and assessing genetic variation in Vicia faba and other out-breeding plants at the infra-specific level. Negative correlation was indicated between seed globulins and both seed albumins and seed weight. Princpal component analysis and cluster analyses indicated higher role of seed albumins over seed globulins in genetic variation within Vicia faba in Egypt.

Abd El-Zaher M.A. Mustafa

2007-01-01

316

Studies on natural radioactivity of some egyptian building materials  

International Nuclear Information System (INIS)

Using high-resolution y-rays spectrometry, the natural radioactivity of 14 samples of natural and o manufactured Egyptian building materials have been investigated. The samples were collected from local market and construction sites. From the measured gamma-ray spectra, specific activities were determined. The radium equivalent activity in each sample was estimated. Radiological evaluations of these materials indicate that all materials meet the external gamma-ray dose limitation. Calculation of concentration indices by assuming a Markkanen room model is constructed from these materials, to find the excess gamma-ray dose taken over that received from the outdoors. The Austrian Standard ONORM S 5200 is used in testing the building materials

2004-02-24

317

Underuse of controller medications in Egyptian asthmatic children  

Directory of Open Access Journals (Sweden)

Full Text Available Background: International guidelines recommend daily use of controller medications for children with persistent asthma. Several studies from different regions of the world have reported low asthma control among children. Objectives: To assess the frequency of underuse of controller medications in Egyptian children and to clarify the causes and predictors for this underuse. Methods: This observational cross-sectional study was held over a 12-month-period in Zagazig University Hospitals, including 460 children with persistent asthma. All studied patients were submitted to careful history taking, proper medical examination and subsequent sharing, with their parents, in filling a previously designated Arabic asthma interview format concerning the disease course, medications, parents' beliefs about asthma, and causes of underuse. Results: Of 460 children who have persistent asthma, 84.4% were underusers of controller therapy, with 63.5% reporting no controller use at all and 21.3% reporting improper use. More than half of the studied patients received their medications in emergency department (52.8%, and follow up with a general practitioner (52.2% with less attendance to our outpatient asthma clinic (15.2%. The most important causes of underuse are non-prescription of controller drugs by managing physician (45% and financial cost (28%. Furthermore, predictors of this underuse include false beliefs about asthma (OR = 56.2; 95% CI: 13.5-232, P<0.05, negative family history of atopy (OR = 2.4; 95% CI: 1.10-5.18, P<0.05, younger age of the patients (P< 0.05, and general practitioner as the treating physician (OR = 3.5; 95% CI: 1.99-6.16, P<0.05. Conclusion: There is high frequency of underuse of controller medications among Egyptian asthmatic children. Non-prescription of controller medications by managing physician and financial cost remain the most important direct causes of underuse.

Osama Amer

2013-01-01

318

Physical Deterioration of Egyptian Limestone Affected by Saline Water  

Directory of Open Access Journals (Sweden)

Full Text Available This study is the second in a series of experiments that describe the chemical, physical and thermal properties of archaeological limestone affected by salt and saline water in Egypt. This research aims to study the aggressive physical effects of different types of salts dominated in saline water and their different mechanisms on the acceleration of weathering processes that affect Egyptian limestone. It presents a multidisciplinary approach to characterize, at both micro/macro scales, the behavior of a limestone widely used as a construction material in most of Egyptian monuments when interacting with some types of salt solutions of various concentrations. A systematic optical, morphological, physical and mechanical analysis of the fresh and weathered stone samples were used to evaluate different characteristics through using scientific some techniques such as optical microscope (OP and scanning electron microscope (SEM. In addition to the using of some special computer programs that were used to define different physical and mechanical properties such as weight changes, bulk density, total porosity, water uptake, water content, thermal dilatation and abrasion resistant. The results proved that all investigated samples were gradually affected by the types of salinity paths and salt concentrations. These results will serve as a database for the future comparison of long term behavior of stones before and after the planned conservation of the entire area. So, it is pertinent to device some scientific methods and interventions to reduce all factors of salt effects and removing their harmful aspects from historic fabric of the archaeological buildings through some scientific recommendations

Mohammed EL-GOHARY

2013-12-01

319

Angiographic characteristics of central serous chorioretinopathy in an Egyptian population  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To describe and analyze the demographic characteristics and to determine the angiographic features of acute central serous chorioretinopathy(CSCR in an Egyptian population. METHODS: A series of consecutive patients presenting with acute idiopathic CSCR to Mansoura Ophthalmology Center Mansoura University who underwent fluorescein angiography (FA within a 3-year-period (between January 1, 2007 and December 31, 2009 was retrospectively studied. Patient demographics and angiographic features were studied. Results were compared to those of other Western and Asian populations. RESULTS: Fluorescein angiograms of 86 patients were analyzed. 91% were males. The age range of patients was 24 - 49 years, with a mean age of (38±6 years. The right eye was the presenting eye in 47% of patients. Eighty-seven percent of eyes showed delayed choroidal filling. Thirty-five percent of patients had more than one point of leakage. The macula was the most common site of fluorescein leakage seen in 79% of patients. Peripheral leakage was seen in 14% of patients while peripapillary leakage was seen in 12% of patients. The inkblot leakage pattern was found in 53% of patients. The presenting eye had RPE atrophic changes in 84% of cases. The other eye was assessed in 44 patients (51%. Fifty-five percent of them had signs of RPE atrophic changes. CONCLUSION: In the Egyptian population, CSCR is seen at younger age with higher male-to-female ratio and more frequent smokestack leaks than other populations. Despite younger age group, this series of patient showed higher frequency of bilateral and multifocal disease compared to other studies. Roles of psychological stress and choroidal ischemia in pathogenesis of CSCR need further evaluation.

Maha M Shahin

2013-06-01

320

Compensating Differentials and the Value of Job Security: Evidence from the Egyptian Public Sector  

Directory of Open Access Journals (Sweden)

Full Text Available This paper considers the determinants of male and female pay in the public and private sectors by estimating a joint model of sector allocation and wage determination using cross-sectional data from the Egyptian 1987 and 1997 labour force surveys. A model of compensating wage differentials is defined and estimated, in order to quantify the value of arguably the three most important non-pecuniary aspects of public sector employment: job security, fringe benefits (especially comprehensive retirement pensions and lower effort and shorter hours which allow workers to supplement income through obtaining a second job. Estimates of the public-private differentials, correcting for differences in characteristics and selectivity, indicate a public sector disadvantage for males and a small advantage for females in 1987. Relative public sector wages improved for both males and females in 1997, and when adjustments for non-wage benefits are included, public sector premia are observed in all segments of the public sector for both males and females. The results highlight the importance of job security as the major factor determining the persistence of queues for public sector jobs in Egypt.

Mona Said

2011-12-01

 
 
 
 
321

Impact of climate change on possible scenarios for Egyptian agriculture in the future  

Energy Technology Data Exchange (ETDEWEB)

If no timely measures are taken to adapt Egyptian agriculture to possible climate warming, the effects may be negative and serious. Egypt appears to be particularly vulnerable to climate change because of its dependence on the Nile River as the primary water source, its large traditional agricultural base, and its long coastline, already undergoing both intensifying development and erosion. A simulation study characterized potential yield and water use efficiency decreases on two reference crops in the main agricultural regions with possible future climatic variation, even when the beneficial effects of increased CO{sub 2} were taken into account. On-farm adaptation techniques which imply no additional cost to the agricultural system, did not compensate for the yield losses with the warmer climate or improve the crop water-use efficiency. Economic adjustments such as the improvement of the overall water-use efficiency of the agricultural system, soil drainage and conservation, land management, and crop alternatives are essential. If appropriate measures are taken, negative effects of climate change in agricultural production and other major resource sectors (water and land) may be lessened. 3 figs., 6 tabs., 20 refs.

El-Shaer, H.M. [Cairo University, Cairo (Egypt); Rosenzweig, C. [Columbia University and NASA-Goddard Institute for Space Studies, New York (United States); Iglesias, A. [Internacional de Ingenieria y Estudios Tecnicos INTECSA, Madrid (Spain); Eid, M.H. [Soils and Water Resources Institute, Ministry of Agriculture, Cairo (Egypt); Hillel, D. [University of Massachusetts, Boston (United States)

1997-06-01

322

Effect of irradiation and storage on biogenic amine contents in ripened Egyptian smoked cooked sausage  

International Nuclear Information System (INIS)

The effects of ?-irradiation upon the biogenic amine inventory in Egyptian smoked cooked sausages were investigated for the first time during storage for up to 90 days at 4 ° C. Typical contents of biogenic amines in non-irradiated sausages ranged between 125.50 and 596.18 mg/kgDW; irradiation with 4 and 6 kGy decreased said total contents to 105.20-94.82 and 104.98-26.44 mg/kgDW respectively, by the end of storage. Putrescine and cadaverine were the major amines in non-irradiated samples - where it accounted for 33% and 29% respectively, of the total by 90 days; however, tyramine dominated in irradiated samples with 2, 4 and 6 kGy, where it accounted for 44, 52 and 42%. On the other hand, the histamine content in non-irradiated sausage by 90 days of storage (i.e. 109.12 mg/kgDW) clearly exceeded the maximum allowable of 50 mg/kg, unlike happened in their irradiated counterparts. Therefore, the dramatic reduction observed in the histamine levels suggests use of this preservation technique for that traditional meat food. (author)

2013-01-01

323

Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients  

Science.gov (United States)

AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients. METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon ? (PEG-IFN?) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFN?2a (70.6%) while 29.4% received PEG-IFN?2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P = 0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P = 0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P = 0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P = 0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P = 0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients.

Ahmed, Walaa H; Furusyo, Norihiro; Zaky, Saad; Sharaf Eldin, Abeer; Aboalam, Hany; Ogawa, Eiichi; Murata, Masayuki; Hayashi, Jun

2013-01-01

324

Coptic loanwords of Egyptian Arabic in comparison with the parallel case of Romance loanwords in Andalusi Arabic, with the true Egyptian etymon of Al-Andalus  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The aim of this article is to compare the results of Bishai’s survey of Coptic loanwords in 1964 with the cases in which the standard Egyptian Arabic dictionary, Hinds and Badawi, attributes some terms to a Coptic origin. A new proposal with the true etymon of Al-Andalus is also provided.

Corriente, Federico

2008-01-01

325

The Realization of the Speech Act of Refusal in Egyptian Arabic by American Learners of Arabic as a Foreign Language  

Science.gov (United States)

This study investigated how the speech act of refusal is realized in Egyptian Arabic by intermediate and advanced American learners of Arabic as a foreign language. It also compared the performance of the learners to that of native speakers of Egyptian Arabic and native speakers of American English. The study aimed to investigate the relationship…

Morkus, Nader

2009-01-01

326

Susceptibility of Saudi Bulinus truncatus to infection with Egyptian Schistosoma haematobium with observations on protein electrophoretic pattern of the snails.  

Science.gov (United States)

A laboratory-based susceptibility study was carried out on snails Bulinus truncatus collected from highland Abha, Asser, Saudi Arabia to Egyptian Schistosoma haematobium to investigate the potential role of Saudi B. truncatus in the transmission of Egyptian S. haematobium and to know the possibility that the parasite might be able to spread into Saudi Arabia. The results revealed that, compared to Egyptian snails, survival of snails at day 25 post-exposure was significantly higher in Saudi B. truncatus ones. The infection rate was higher in Saudi snails as compared to Egyptian ones. The incubation period was shorter in Saudi snails but the duration of cercarial shedding was longer in the Egyptian than in the Saudi snails. The production of S. haematobium cercariae per snail was higher in Egyptian snails than in Saudi ones. These results suggest that Saudi B. truncatus can play a role in the transmission of Egyptian S. haematobium in Saudi Arabia and therefore this parasite might be able to spread into the Kingdom. In addition, electrophoretic analysis of tissue soluble proteins was done to determine the effects of the parasite on both the Egyptian and Saudi snails. The electrophoretic analysis revealed the occasional presence or absence of certain bands in infected snails in comparison with non-infected one. PMID:19329256

Mostafa, Osama M S; Bin Dajem, Saad M; Abu El Einin, Hanaa M

2009-05-12

327

Return Anomalies “Disposition Effect and Momentum”: Evidence from the Egyptian Stock Market  

Directory of Open Access Journals (Sweden)

Full Text Available Purpose: The persistence of momentum in stock returns across both developed and emerging markets and the challenges that it poses against the Efficient Market Hypothesis created a need to explain its existence. Grinblatt and Han (2005 formulated a model to explain momentum using a well documented behavioral bias which is the Disposition effect. The focus of this paper is to analyze whether disposition effect drives momentum in the Egyptian stock market as one of the growing emerging markets that faces a considerable lack in behavioral studies. Design/methodology/approach: The study is quantitative in nature studying whether disposition effect drives momentum using a sample of 48 companies through the time period 2004–2010. The relation between disposition effect and momentum will be analyzed empirically using Fama Macbeth cross-sectional regression. Findings: Results show that there is no momentum in stock returns in the Egyptian stock market. In addition they show that disposition effect does not drive momentum in the Egyptian stock market as there is no significant relation between expected return and capital gain overhang. The results reveal useful insights about the Egyptian stock market that can be of beneficial use for both practitioners and academics. Research limitations/implications: Limited number of active companies in the Egyptian stock market as well as the limited available historical data poses some restrictions in the implementation of Fama Macbeth regression and the calculation of reference price. In addition analyzing the profitability of momentum strategies across different market states may be required to provide complete picture about momentum in the market. Practical implications: Relative strength strategies do not earn abnormal return in the Egyptian stock market, so practitioners are not advised to follow such strategies. In addition more advanced market mechanisms should be applied in the Egyptian stock market to improve its efficiency as well as increase the speed of information dissemination in the prices. Originality/value: Detailed analysis of literature review reveals a significant gap in academic studies about the Egyptian stock market. This paper aims to fill this gap by analyzing whether there is momentum in stock returns and whether disposition effect drives momentum in the Egyptian stock market that differs from other markets where Grinblatt and Han (2005 has been previously applied and hence this provides an out of sample test of the model.

Ahmed M. Sakr

2014-01-01

328

Interleukin-12B gene polymorphism frequencies in Egyptians and sex-related susceptibility to hepatitis C infection.  

Science.gov (United States)

Hepatitis C virus (HCV) infection is a major health problem worldwide. Egypt is the country with the highest HCV infection epidemic in the world. Interleukin (IL)-12 is a cytokine that has been shown to have a potent role as an antiviral cytokine. IL-12 is a heterodimer of the polypeptides p35 and p40. IL-12 B, the gene encoding IL-12 p40, is polymorphic, and a functional single-nucleotide polymorphism (SNP) of the 3'-untranslated region at position rs3212227 was associated with apparent resistance to HCV. The genotype distribution of this polymorphism differs by race. This study is sought to identify the genotype distribution of the IL-12 SNP rs3212227 polymorphism in Egyptians and to assess its role in susceptibility to chronic HCV infection alone or in a sex-dependent way. The study included 238 subjects: 100 healthy controls and 138 patients with HCV infection. The IL-12 SNP rs3212227 was genotyped by the polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Results showed a genotype frequency of 46%, 39%, and 15% for AA, AC, and CC IL-12 genotypes, respectively. No significant result (P=0.5) was shown in the differential distribution of the IL-12 SNP genotypes between controls and patients with HCV infection. Nonetheless, this difference in the IL-12 genotype distribution was significant (0.005) when it was stratified according to sex; moreover, the C allele distribution in men and women differed with a statistically high significance (P=0.0001) in controls versus HCV patients. In conclusion, the IL-12 SNP rs3212227 polymorphism confers a susceptibility to HCV infection in a sex-dependent way in Egyptians. PMID:23600862

Youssef, Samar Samir; Abd El Aal, Asmaa Mostafa; Nasr, Amal Soliman; el Zanaty, Taher; Seif, Sameh Mohamed

2013-08-01

329

Phenolics, Selenium, Vitamin C, Amino Acids and Pungency Levels and Antioxidant Activities of Two Egyptian Onion Varieties  

Directory of Open Access Journals (Sweden)

Full Text Available Selenium, vitamin C, pungency, amino acids, phenolics content and antioxidant activities of two Egyptian onion varieties, namely white (Giza-6 and red (Beheri onions have been studied. Data analysis showed that the red variety presents higher values for selenium, vitamin C and sulphur-containing amino acids. Concerning pungency, white onion can be classified as intermediate pungency (8.24 ?mol of Pyruvic acid/100 g fresh wt. and red as pungent (11.37 ?mol of pyruvic acid/100 g fresh wt.. The phenolic acids, flavonols, anthocyanins and total phenolics content in red variety (81.59, 70.38, 7.56 and 187.17 mg/100 g fresh wt., respectively were higher than for white variety (72.47, 32.49, 4.90 and 131.65 mg/100 g fresh wt., respectively. Consequently, antioxidant activity was higher for the red variety. Correlation analysis indicates that phenolic compounds beside other factors including Se and sulphur-containing amino acid contents play the major role in the antioxidant activity of onion bulbs. The antioxidant capacity of freeze dried powder from both onion varieties was also tested in sunflower oil-in-water emulsions and hydroperoxide formation was monitored during storage at 40°C. In accordance with differences in Se, sulphur-containing amino acid and phenolics content, Egyptian red onions had better antioxidant activity, while white onions was only effective in the early stages of the oxidation process. These data indicates that red variety has higher potential health benefits related to the presence of antioxidant compounds.

Y.A. Elhassaneen

2009-01-01

330

Characterization of ?-cypermethrin exposure in Egyptian agricultural workers.  

Science.gov (United States)

Pyrethroids are neurotoxic insecticides that exert their effects by prolonging the open time of sodium channels, which increases the duration of neuronal excitation. ?-cypermethrin (?CM) is derived from the 8-stereoisomers that together make up the pyrethroid cypermethrin, which is one of the most common pyrethroids being used in agriculture throughout the world. The objective of this study was to characterize the occupational exposure to ?CM in a cohort of Egyptian agriculture workers (n=37) before, during and after 6-10 consecutive days of application of ?CM to cotton fields. Daily spot urine specimens were collected and analyzed by GC-MS NCI for the ?CM metabolites 3-phenoxybenzoic acid (3-PBA) and cis-3-(2',2'-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis-DCCA). Prior to ?CM application, median urinary levels of 3-PBA (4.59nmol/g creatinine) were greater than cis-DCCA (0.33nmole/g creatinine) demonstrating low background exposures to pyrethroids. During the application period for ?CM, median urinary levels of both biomarkers increased (13.44nmol 3-PBA/g creatinine and 7.76nmol cis-DCCA/g creatinine) and ranged from 2.3-93.96nmol 3-PBA/g creatinine and 0.09-90.94nmol cis-DCCA/g creatinine, demonstrating that workers had a wide range of exposures to ?CM. The data also demonstrate that pesticide applicators had greater exposures to ?CM than workers who play a supporting role in the seasonal application of pesticides on the cotton crop. Urinary cis-DCCA and 3-PBA concentrations were elevated at 7-11 days after the cessation of ?CM application, compared to baseline levels. This study is the first to use these biomarkers to quantify occupational exposures specifically to ?CM. This urinary biomarker data will be useful for estimating daily internal dose, comparing exposures across job categories within the Egyptian pesticide application teams, and for modeling human exposures to ?CM. PMID:24269189

Singleton, Steven T; Lein, Pamela J; Farahat, Fayssal M; Farahat, Taghreed; Bonner, Matthew R; Knaak, James B; Olson, James R

2014-01-01

331

Morphology of the lingual papillae in the Egyptian rousette bat (Rousettus aegyptiacus).  

Science.gov (United States)

The dorsal lingual surface of the Egyptian rousette bat was examined by scanning electron microscopy. Filiform, fungiform and vallate papillae were observed. The filiform papillae were distributed over the entire dorsal surface of the tongue. The filiform papillae notably differed in morphology by their location on the tongue and could be classified into 5 types: 1) scalelike, 2) small crown-like, 3) giant trifid, 4) large crown-like, 5) conical papillae. The fungiform papillae were present rounded bodies on the anterior 2/3 of the tongue. The Egyptian rousette bat showed the a triangular arrangement of the three vallate papillae, with the apex of the triangle directed posteriorly. These findings indicate that the tongue of the Egyptian rousette bat is similar to that of the large flying fox. PMID:23429050

Emura, Shoichi; Okumura, Toshihiko; Chen, Huayue

2012-01-01

332

Effect of breeding conditions on thyroid and sex hormones of pregnant and lactating Egyptian buffaloes  

International Nuclear Information System (INIS)

The present investigation was planned in order to clarify the effect of breeding conditions on the thyroid and sex hormones of Egyptian female buffaloes during gestation. Parturition and lactation. Serum levels of triiodothyronine (T3), thyroxine (T4), estradiol and progesterone were studied in two groups of buffaloes, aging 5-7 years.Starting from the 5th month of gestation till the 9th week of lactation. The first group was maintained on standard farm conditions and the second on ordinary traditional village conditions. The data revealed that the way of breeding has no effect on thyroid and sex hormones and no differences were observed. Accordingly, pregnancy and lactation were not affected. These results indicate that the Egyptian buffaloes have high adaptability towards the surrounding conditions so, its worthy to breed such beneficial animals without any additional effort or expenses. These factors should be considered for improving the Egyptian economy

2001-01-01

333

Verification of annual growth rings in Egyptian trees by C-14 method  

Energy Technology Data Exchange (ETDEWEB)

Annual growth rings in trees were thought to be due to sharp seasonal variations in the precipitation rates during the year. Accordingly temperature zone trees such as Egyptian trees were supposed to be away from this phenomenon. The temperature zones which are meant here are those of no sharp seasonal variations in the precipitation rates. The present study applied carbon-14 dating to prove that the growth rings in some Egyptian trees are annual. The method was based on the tropospheric measurements of C-14 during the period 1954-1981. C-14 exhibited a sharp peak resulting from the ever greater series of nuclear tests during 1963-1965. The presence of this peak for Egyptian trees proved that they form annual growth rings. (orig.).

Belacy, N.; Abou El-Nour, F. (Atomic Energy Establishment, Cairo (Egypt). Nuclear Chemistry Dept.); Jacoby, G.C. (Columbia Univ., Palisades, NY (USA). Lamont-Doherty Geological Observatory)

1990-01-01

334

Verification of annual growth rings in Egyptian trees by C-14 method  

International Nuclear Information System (INIS)

Annual growth rings in trees were thought to be due to sharp seasonal variations in the precipitation rates during the year. Accordingly temperature zone trees such as Egyptian trees were supposed to be away from this phenomenon. The temperature zones which are meant here are those of no sharp seasonal variations in the precipitation rates. The present study applied carbon-14 dating to prove that the growth rings in some Egyptian trees are annual. The method was based on the tropospheric measurements of C-14 during the period 1954-1981. C-14 exhibited a sharp peak resulting from the ever greater series of nuclear tests during 1963-1965. The presence of this peak for Egyptian trees proved that they form annual growth rings. (orig.)

1990-01-01

335

Blindness and Visual Impairment among Egyptian Glaucoma Patients  

Science.gov (United States)

Purpose. Glaucoma is the second commonest cause of blindness worldwide. Visual fields and intraocular pressures are optimum outcomes to be assessed in developed countries. Visual acuity as an outcome is the key player when assessing blindness in developing countries. The aim of this study is to assess visual impairment and blindness in glaucoma patients and to identify the bulk they represent in comparison to nonglaucoma patients in the same practice setting. Methods. Patients attending outpatient clinics of Cairo University Hospitals were enrolled in this cross-sectional study. Clinical data collected for these patients included their demographic data, best obtained visual acuity, and whether or not they have had an established diagnosis of glaucoma. Results were compared at 95% confidence intervals. Results. 988 eyes of 494 patients were included for this study. Their mean visual acuity was 6/24 (±3 Snellen lines). Legal blindness was found in 5% and 4% of glaucoma and nonglaucoma groups, respectively. There were high odds for finding eyes with total blindness due to glaucoma. That was statistically significant (P < 0.05). Conclusions. A large proportion of glaucoma patients suffered from blindness in at least one eye. Interventional strategies are recommended regarding visual disability among Egyptian glaucoma patients.

Eldaly, M. A.; Salama, M. M.; Abu Eleinen, K. G.; Ghalwash, D.; Youssef, M.; El-Shiaty, A. F.

2014-01-01

336

Distribution of Fungi in the Sandy Soil of Egyptian Beaches  

Directory of Open Access Journals (Sweden)

Full Text Available The mycobiota of the sandy soil of Egyptian beaches was investigated in thirty six sand samples collected from nine different localities in Egypt. The filamentous fungi were identified and assigned to thirty one genera and fifty one species. Greater populations as well as a wider spectrum range of fungal genera and species were obtained in sandy soil of Alexandria beach while Balteem beach was the poorest one. The total count of the genus or species did not always follow the number of cases of isolation. Most of the genera detected belonged to the Deuteromycotina with fewer proportions belonging to the Ascomycotina and Zygomycotina. The genera of highest incidence and their respective numbers of species were: Penicillium (35.72%, 6 spp. and Aspergillus (30.28%, 16 spp.. The species which showed the highest incidence in all cases was P. chrysogenum, followed by P. citrinum, A. flavus, Chaetomium murorum and Trichoderma viride. Several other genera and species were detected at quite low occurrence.

Fatma F. Migahed

2003-01-01

337

Fish sensitization in a group of allergic Egyptian children  

Directory of Open Access Journals (Sweden)

Full Text Available Background: There are no published data on fish allergy in Egypt. Objective: We sought to screen for the frequency of fish sensitization in a group of atopic Egyptian infants and children in relation to their demographic and phenotypic data. Methods: We consecutively enrolled 87 allergic children; 1-15 years old (median 5.0 yr. The study measurements included clinical evaluation for the site and duration of allergy, possible precipitating factors, and family history of allergy as well as skin prick testing with a commercial fish extract, and serum fish specific and total IgE estimation. Results: Twelve subjects (13.8% were sensitized to fish as evidenced by positive skin prick test (SPT results; five (41.7% of them gave a history suggestive of fish allergy compared to two (2.7% of the non-sensitized children (p=0.00. The SPT results did not vary significantly with age, gender, family history of atopy, or serum total or fish specific IgE (SpIgE. Conclusion: Fish sensitization does not seem to be rare in atopic children in Egypt. It can be associated with any clinical form of allergy and the causal relationship needs meticulous evaluation. Wider scale population-based studies are needed to assess the prevalence of fish allergy and its clinical correlates in our country.

Elham Hossny

2013-01-01

338

Nuclear safety requirements for operation licensing of Egyptian research reactors  

International Nuclear Information System (INIS)

From the view of responsibility for health and nuclear safety, this work creates a framework for the application of nuclear regulatory rules to ensure safe operation for the sake of obtaining or maintaining operation licensing for nuclear research reactors. It has been performed according to the recommendations of the IAEA for research reactor safety regulations which clearly states that the scope of the application should include all research reactors being designed, constructed, commissioned, operated, modified or decommissioned. From that concept, the present work establishes a model structure and a computer logic program for a regulatory licensing system (RLS code). It applies both the regulatory inspection and enforcement regulatory rules on the different licensing process stages. The present established RLS code is then applied to the Egyptian Research Reactors, namely; the first ET-RR-1, which was constructed and still operating since 1961, and the second MPR research reactor (ET-RR-2) which is now in the preliminary operation stage. The results showed that for the ET-RR-1 reactor, all operational activities, including maintenance, in-service inspection, renewal, modification and experiments should meet the appropriate regulatory compliance action program. Also, the results showed that for the new MPR research reactor (ET-RR-2), all commissioning and operational stages should also meet the regulatory inspection and enforcement action program of the operational licensing safety requirements. (author)

2000-06-01

339

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients  

Directory of Open Access Journals (Sweden)

Full Text Available The schistosomal parasite plays a critical role in the development of malignant lesions in different organs. The pathogenesis of cancer is currently under intense investigation to identify reliable prognostic indices for disease detection. The objective of this paper is to evaluate certain biochemical parameters as diagnostic tools to efficiently differentiate between colonic carcinoma and colonic carcinoma associated with schistosomal infection among Egyptian patients. The parameters under investigation are interleukin 2 (IL-2, tumour necrosis factor alpha (TNF-?, carcinoembryonic antigen (CEA levels, tissue telomerase, pyruvate kinase (PK, glucose-6-phosphate dehydrogenase (G-6-PD and lactate dehydrogenase (LDH enzyme activities. The results revealed a significant elevation in the level of the tumour markers IL-2, TNF-? and CEA as well as the activities of LDH, telomerase and G-6-PD among non-bilharzial and bilharzial colonic cancer groups, with a more potent effect in bilharzial infection-associated colonic cancer. A significant inhibition in PK activity was recorded in the same manner as compared to normal tissues. The efficacy of this biomarker was also evaluated through detecting sensitivity, specificity, negative and positive predictive values. In conclusion, schistosomal colonic carcinoma patients displayed more drastic changes in all parameters under investigation. The combination of the selected parameters succeeded in serving as biomarkers to differentiate between the two malignant types.

Manal Abdel Aziz Hamed

2011-05-01

340

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The schistosomal parasite plays a critical role in the development of malignant lesions in different organs. The pathogenesis of cancer is currently under intense investigation to identify reliable prognostic indices for disease detection. The objective of this paper is to evaluate certain biochemic [...] al parameters as diagnostic tools to efficiently differentiate between colonic carcinoma and colonic carcinoma associated with schistosomal infection among Egyptian patients. The parameters under investigation are interleukin 2 (IL-2), tumour necrosis factor alpha (TNF-?), carcinoembryonic antigen (CEA) levels, tissue telomerase, pyruvate kinase (PK), glucose-6-phosphate dehydrogenase (G-6-PD) and lactate dehydrogenase (LDH) enzyme activities. The results revealed a significant elevation in the level of the tumour markers IL-2, TNF-? and CEA as well as the activities of LDH, telomerase and G-6-PD among non-bilharzial and bilharzial colonic cancer groups, with a more potent effect in bilharzial infection-associated colonic cancer. A significant inhibition in PK activity was recorded in the same manner as compared to normal tissues. The efficacy of this biomarker was also evaluated through detecting sensitivity, specificity, negative and positive predictive values. In conclusion, schistosomal colonic carcinoma patients displayed more drastic changes in all parameters under investigation. The combination of the selected parameters succeeded in serving as biomarkers to differentiate between the two malignant types.

Hamed, Manal Abdel Aziz; Ahmed, Samia Abdel Aziz; Khaled, Hussein Moustafa.

 
 
 
 
341

Behaviour of uranium during processing of Egyptian monazite  

International Nuclear Information System (INIS)

The present work deals with the study of the behaviour of uranium during alkaline processing of Egyptian monazite, followed by selective separation of thorium and uranium from lanthanides by leaching of the hydroxide cake with ammonium carbonate solutions. This method is based on the dissolution of thorium and uranium hydroxides in ammonium carbonate solutions in the form of soluble ammonium thorium and uranyl carbonate complexes, while the lanthanides hydroxides form sparingly soluble double carbonates. The obtained carbonate solutions, containing carbonate complexes of thorium and uranium are decomposed with steam in steel autoclaves. Uranium is completely recovered with thorium (99.7%) by alkaline processing of monazite concentrate in ball mill autoclaves at 1500C during 2.5 hours. The selective carbonate autoclave processing of hydroxide cake with ammonium carbonate-bicarbonate solutions show that high recovery of uranium (94.7%) with complete recovery of thorium (99.4%) and their separation from lanthanides are attained at 70-80oC, pressure 5-10 atm during 1h. The decomposition of carbonate complexes of thorium and uranium is favourably carried out in autoclaves at 120oC and steam pressure 2 atm during 10 min. Uranium is nearly completely recovered (98.4%) with thorium (99.8%) in the thorium concentrate produced. Meanwhile, the recovery of lanthanides is low and does not exceed 1.1%. The produced thorium concentrate contains 67.8% Th and 4.6% U. (author)

2000-09-09

342

Radiological responses of different types of Egyptian Mediterranean coastal sediments  

International Nuclear Information System (INIS)

The aim of this study was to identify gamma self-absorption correction factors for different types of Egyptian Mediterranean coastal sediments. Self-absorption corrections based on direct transmission through different thicknesses of the most dominant sediment species have been tested against point sources with gamma-ray energies of 241Am, 137Cs and 60Co with 2% uncertainties. Black sand samples from the Rashid branch of the Nile River quantitatively absorbed the low energy of 241Am through a thickness of 5 cm. In decreasing order of gamma energy self-absorption of 241Am, the samples under investigation ranked black sand, Matrouh sand, Sidi Gaber sand, shells, Salloum sand, and clay. Empirical self-absorption correction formulas were also deduced. Chemical analyses such as pH, CaCO3, total dissolved solids, Ca2+, Mg2+, CO32-, HCO3- and total Fe2+ have been carried out for the sediments. The relationships between self absorption corrections and the other chemical parameters of the sediments were also examined.

2010-08-01

343

Radiological responses of different types of Egyptian Mediterranean coastal sediments  

Energy Technology Data Exchange (ETDEWEB)

The aim of this study was to identify gamma self-absorption correction factors for different types of Egyptian Mediterranean coastal sediments. Self-absorption corrections based on direct transmission through different thicknesses of the most dominant sediment species have been tested against point sources with gamma-ray energies of {sup 241}Am, {sup 137}Cs and {sup 60}Co with 2% uncertainties. Black sand samples from the Rashid branch of the Nile River quantitatively absorbed the low energy of {sup 241}Am through a thickness of 5 cm. In decreasing order of gamma energy self-absorption of {sup 241}Am, the samples under investigation ranked black sand, Matrouh sand, Sidi Gaber sand, shells, Salloum sand, and clay. Empirical self-absorption correction formulas were also deduced. Chemical analyses such as pH, CaCO{sub 3}, total dissolved solids, Ca{sup 2+}, Mg{sup 2+}, CO{sub 3}{sup 2-}, HCO{sub 3}{sup -} and total Fe{sup 2+} have been carried out for the sediments. The relationships between self absorption corrections and the other chemical parameters of the sediments were also examined.

El-Gamal, A., E-mail: ayman_elgamal@yahoo.co [Department of Oceanography, Coastal Research Institute, National Water Research Center, 15 Elpharaana St., Elshallalat, Postal code 21514, Alexandria (Egypt); Rashad, M. [Land and Water Technologies Department, Arid Land Cultivation and Development Research Institute, Mubarak City for Scientific Research, Burg El-Arab, Alexandria (Egypt); Ghatass, Z. [Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria (Egypt)

2010-08-15

344

Gonadotropins studies in female egyptian subjects under different physiological conditions  

International Nuclear Information System (INIS)

This study is concerned with the role of the hypothalamic hypophyseal regulatory hormonal mechanisms in the control of gonadal secretions in a selected normal egyptian female subjects with varying ages under different physiological conditions. The study allowed precise definition of the modulator influence of a number of key factors triggering appropriate alteration in circulating serum levels of FSH and LH determined by IRMA technique in pre-pubertal female children (9-11), post-pubertal adolescents females (13-16). Adult married females (27-33) and post-menopausal (58-63). The levels of FSH and LH were increased markedly with age but children less than 11 years old had only nocturnal increase in levels of FSH (p.O.I) and LH(P< 0.001). post-pubertal aged girls had significant nocturnal elevation only of LH levels (P< 0.001), adult married females did not exhibit significant difference in gonadotropin concentrations. whereas significant elevation in FSH and LH levels (P<0.001) in post-menopausal females were observed

2002-01-01

345

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients.  

Science.gov (United States)

The schistosomal parasite plays a critical role in the development of malignant lesions in different organs. The pathogenesis of cancer is currently under intense investigation to identify reliable prognostic indices for disease detection. The objective of this paper is to evaluate certain biochemical parameters as diagnostic tools to efficiently differentiate between colonic carcinoma and colonic carcinoma associated with schistosomal infection among Egyptian patients. The parameters under investigation are interleukin 2 (IL-2), tumour necrosis factor alpha (TNF-?), carcinoembryonic antigen (CEA) levels, tissue telomerase, pyruvate kinase (PK), glucose-6-phosphate dehydrogenase (G-6-PD) and lactate dehydrogenase (LDH) enzyme activities. The results revealed a significant elevation in the level of the tumour markers IL-2, TNF-? and CEA as well as the activities of LDH, telomerase and G-6-PD among non-bilharzial and bilharzial colonic cancer groups, with a more potent effect in bilharzial infection-associated colonic cancer. A significant inhibition in PK activity was recorded in the same manner as compared to normal tissues. The efficacy of this biomarker was also evaluated through detecting sensitivity, specificity, negative and positive predictive values. In conclusion, schistosomal colonic carcinoma patients displayed more drastic changes in all parameters under investigation. The combination of the selected parameters succeeded in serving as biomarkers to differentiate between the two malignant types. PMID:21655820

Hamed, Manal Abdel Aziz; Ahmed, Samia Abdel Aziz; Khaled, Hussein Moustafa

2011-05-01

346

Geostrophic current patterns off the Egyptian Mediterranean coast  

Directory of Open Access Journals (Sweden)

Full Text Available Using objectively analysed hydrographic data,currents have been calculated off the Egyptian Mediterraneancoast at the surface and at 30, 50, 75, 100, 200 and 300 mdepths for the four seasons.    The surface circulation is dominated by an anticyclonic circulationoff Salum Bay in winter, spring and summer. In nearshore areas,the current flows eastwards at the shallower levels but westwardsat the deeper levels.    Off the Nile Delta, the current is almost eastward with a highervelocity in summer and autumn, while in spring it is very weak.Off the area between Port Said and Rafah, there is a clear cycloniccirculation appearing in all seasons except winter. At 50 and75 m depth, the velocity of the circulation is weak. At 100 m depth,the circulation that appeared between Matruh and Alamen in summer decreasesin area and magnitude at the former depths.    At 200 and 300 m in winter, the current velocity is quite low. Inspring the current flows southwards off the area between Rafahand Port Said. In summer, the current off the area between PortSaid and Rafah is quite strong and flows to the south. The situationin autumn is quite similar to that in summer, except in the easternarea, where the current is a westward one.

Mohamed Salama Kamel

2010-06-01

347

Count like an egyptian a hands-on introduction to ancient mathematics  

CERN Document Server

The mathematics of ancient Egypt was fundamentally different from our math today. Contrary to what people might think, it wasn't a primitive forerunner of modern mathematics. In fact, it can't be understood using our current computational methods. Count Like an Egyptian provides a fun, hands-on introduction to the intuitive and often-surprising art of ancient Egyptian math. David Reimer guides you step-by-step through addition, subtraction, multiplication, and more. He even shows you how fractions and decimals may have been calculated-they technically didn't exist in the land of the pharaohs.

Reimer, David

2014-01-01

348

The Relationship between Employee Perceptions of Equity and Job Satisfaction in the Egyptian Private Universities  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of this study was to investigate the relationships between employee perception of equity and job satisfaction in the Egyptian private universities. Data were gathered using a face-to-face survey of 80 teaching staff members at three Egyptian universities. Findings revealed positive relationships between perceptions of equity, where a "motivator" was the outcome in the comparison, and job satisfaction. The study also revealed that there was no relationship between perceptions of equity and job satisfaction where a "hygiene factor" was the outcome in the comparison. This study is exploratory and findings are not conclusive. Its implications and limitations are discussed.

Mohamed Hossam El-Din KHALIFA

2010-05-01

349

Whole-body three-dimensional multidetector CT of 13 Egyptian human mummies.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVE: The purpose of this article is to assess the role of multidetector CT and three-dimensional (3D) reconstructions in noninvasive studies of Egyptian mummies. MATERIALS AND METHODS: We studied 13 mummies from the Egyptian Museum in Torino, Italy, dating from Dynasty III to Dynasty IV (2650-2450 B.C.) and from the Ptolemaic period (332-30 B.C.) to the Roman period (30 B.C.-A.D. 395), using a multidetector CT unit with a single volumetric acquisition of the whole body, including lower ...

Gandini, Giovanni; Boano, Rosa

2003-01-01

350

Egyptian And International Automotive Diesel. Fuels: Specifications Meeting Challenges To Refining Industry  

International Nuclear Information System (INIS)

This paper presents a brief summary and comparison of Egyptian automotive diesel fuel to the international one. Recent legislation all over the world, requiring further reduction in sulfur, aromatics, T90 and T95 and increasing cetane value of the transportation diesel fuels, presents numerous technical and economic challenges to the refiners. While refiners grapple with these challenges, they will also face pressure from the increased demand of transportation diesel fuel and tighter capital restrictions. Overcome of these challenges makes a fair competition. A comparison of the Egyptian automotive diesel fuel and the international one will be a guide to locally and globally facing these challenges

2004-12-27

351

Biochemical and physiological changes in Egyptian Nile fish subjected to varying levels of gamma irradiation  

International Nuclear Information System (INIS)

Radiation is nowadays to be considered as a new parameter in the ecology of water masses. Aquatic organisms, perhaps more than any other group of organisms, are directly exposed to radiation hazard and may be subjected to continuous low-level exposure from bottom material and from internal sources accumulated within their own bodies, originating partly from radionuclides released from nuclear facilities into the aquatic environment. In recent years, a large number of papers have been published on the uptake, concentration and release of radioactive material by aquatic organisms. However, radiation experiments on fish, a major source of food for human consumption, are still very rare and mostly restricted to studies on the effect of irradiation on eggs and larvae. Since the study of the radiation effect on living aquatic organisms, particularly fish, is important in connection with the problems of preserving water resources for the benefit of mankind, the work presented here has been done to ascertain the effect of varying dose-levels of gamma irradiation on two common Egyptian Nile fish species, the catfish Clarias lazera and the Tilapia nilotica. Investigations carried out on Clarias lazera involved blood and muscle analyses as well as growth rate measurements. The results obtained showed impaired haematological levels, changes in weight of muscle proteins and, chiefly, retardation in growth rate. Investigations carried out on Tilapia nilotica revealed changes in the activity of certain digestive enzyme systems, glucose level in blood and concentration of the glycogen store in liver and muscles. In discussing the results obtained the authors have taken the relevant literature into consideration. (author)

1975-06-30

352

The Restoration and Conservation of Egyptian Alabaster Vessels from the Early ERA in Atfiyah Museum Store - Helwan - Egypt  

Science.gov (United States)

Egypt is considered one of the most countries which contain a lot of cultural heritage; the Ancient Egyptian used a lot of stones for his life like: limestone, sandstone, granite and Egyptian Alabaster. The Egyptian Alabaster is used for his daily and eternal life, he made a lot of funerary furniture from this stone like: vessels, statues, Architectural elements in the temples, tombs and canopic jars to preserve his viscera from decomposition like: stomach, liver … etc in the mummification process. Egyptian Alabaster is a sedimentary rock especially chemical- origin sedimentary rocks, it deposits inside caves and around springs which consists of calcium carbonates (CaCO3), they are very fragile "hardness = 3 in Mohs hardness scale". The Egyptian Alabaster vessels expose to a lot of deterioration factors in the burial and exposure environment after excavation. The study case vessels are made of Egyptian alabaster stone and belong to the early era (First and second Egyptian dynasties) in Atfiyah museum store, these vessels exposed to a lot of deterioration factors in the burial and exposure environment like: soil pressure, air temperature variety, relative humidity and salts. The vessels are conserved at the restoration laboratory in Atfiyah museum store by a lot of restoration and conservation processes like: cleaning - consolidation - assembling process for the separated parts and completion for the lost parts.

Radi Abdel Kader, R.; Sayed Mohamed, S.

2013-07-01

353

Determinants of Work Relation Perception: Organizational Culture in Egyptian Workplaces  

Directory of Open Access Journals (Sweden)

Full Text Available This study aimed at investigating different types of organizational cultures common in Egyptian workplaces andhow they might be influenced by the type of ownership (governmental, public, or private, the region in whichthe organization exists (Cairo, North Egypt, or South Egypt, and the organization size (large vs. small.Organizational cultures were divided, according to the Competing Values Model proposed Cameron and Quinn(1999/2006, into four types: Market, Hierarchy, Adhocracy, and Clan cultures. Organizational cultures wereevaluated by developing an Arabic/Egyptian standardized version of the Organizational Climate Measure (OCMprepared originally by Patterson and his colleagues (Patterson et al. 2005. OCM was based on the CompetingValues Model and was designed to assess the four basic dimensions of the model, and it went further to definespecific components (which ranged from 2 to 6 for every dimension, with 4 to 6 items for each component. Inthe OCM, the Clan culture was renamed Human Relations culture, which includes 6 dimensions, and Hierarchyculture became Internal Process culture and included 2 components. Similarly, Adhocracy culture was renamedOpen System culture with 3 components, and Market culture was renamed Rational Goal culture with 6components. A sample of 158 employees working in different professions participated in the study. Their agesranged between 19 to 62 years old and their mean age was 34.94 years (SD = 10.61. 82 (52% were males ad 76(48% were females. A 3X3X2 MANOVA of the data was conducted. Results indicated that privateorganizations got higher scores on Human Relations, Open System, and Rational Goal cultures thangovernmental organizations (but not necessarily the public ones. On the other hand, organizations in NorthEgypt and Cairo got higher scores than their counterparts in South Egypt in Human Relations (integration andtraining, Open System (innovation and most components of Rational Goal culture. However, South Egyptorganizations showed higher level of Internal Process (familiarization and tradition than the organizations inCairo and North Egypt. As for Organization size, it has in general a limited effect on organizational culture butlarge organizations showed significantly higher level of Internal Process (familiarization and Rational Goal(efficiency cultures than small ones, which showed higher level of Open System (innovation culture. Thepatterns of interactions showed that public organizations in the north can have higher level of Open Systemculture (innovation than their private and governmental counterparts. Also, Human Relations culture (especiallytraining can be important in small, family-owned organizations in South and North Egypt in comparison toCairo. Moreover, although private organizations tend to give employees more independence and responsibility,the large ones tend to be more restrictive and formal than public and governmental ones, especially in Cairo(where they usually have their central headquarters. Counter to the common belief, Rational Goal culture (workquality and pressure to work were higher in governmental organizations in South Egypt than private and publicones because of the limited resources available to the private section in this region.

Mohamed Taha Mohamed

2013-11-01

354

Cytokine Gene Polymorphisms in Egyptian Cases with Brain Tumors  

International Nuclear Information System (INIS)

Background: Cytokines are proposed to play important roles in brain tumor biology as well as neuro degeneration or impaired neuronal function. Objectives: This work aimed to check the association of polymorphisms of cytokine genes in Egyptian cases with brain tumors. Methods: This work included 45 cases affected by brain tumors diagnosed as 24 benign and 21 malignant. Their median age was 45 years, and they were 20 males and 25 females. These cases were taken randomly from the Neurosurgery Department of Mansoura University Hospital, Egypt. Case genotypes were compared to 98 healthy unrelated controls from the same locality. DNA was amplified using PCR utilizing sequence specific primers (SSP) for detection of polymorphisms related to TNF-a-308 (G/A), IL-10-1082 (G/A), IL-6-174 (G/C) and IL-1Ra (VNTR) genes. Results: Cases affected with benign brain tumors showed a significant higher frequency of IL-10-1082 A/A [odds ratio (OR=8.0), p<0.001] and IL-6-174 C/C (OR=6.3, p=0.002) homozygous genotypes as compared to controls. Malignant cases, on the other hand, showed significantly higher frequency of IL-6-174 C/C (OR =4.8, p=0.002) homozygous genotype and TNF-a-308 A/A (OR=4.9, p<0.001) homozygous genotype when compared to controls. In the meantime, all cases showed no significant difference regarding the distribution of IL-1Ra VNTR genotype polymorphism compared to controls. Conclusions: Cytokine gene polymorphisms showed a pattern of association with brain tumors which may have potential impact on family counseling and disease management.

2009-06-01

355

A NEW SMALL POTATO PLANTER FOR EGYPTIAN AGRICULTURE  

Directory of Open Access Journals (Sweden)

Full Text Available Reducing the tuber period for potato plants by planting previously grown sprouts is a new technique. Applying this new agricultural methodology requires modification of the potato planter. The theoretical analysis was carried out to obtain information that can help avoid tuber damage during feeding and until it exits the feeding system. Starting from these considerations, a new potato planter with a spoon-based feeding system was designed and built. The tests conducted verified that the new system performed well when dividing tuber pieces into rows: considering the best growth spacing for potatoes is 20÷30 cm, the new system has a 68% distribution versus the 50,62 % of the old one. The tubers’ spacing in rows are evaluated based on tuber voids and tuber doubles. The results show that there is no difference between the two systems’ configurations, while a general consideration about our machine is that it is better at managing small tuber pieces. The void ratios are largely valid within the range of 0.4 up to 0.8 m/s of planted speeds; moreover, the results revealed that the tuber doubles decrease by increasing planting speed and vice versa with tuber voids. The quality of the potatoes planted is evaluated using the Shatter Index (SI %, which shows how the new configuration is more delicate with the tuber pieces (1.5 % against 17.5 % at 10 rpm or 46 % against 94 % at rpm 20. The new configuration could be an interesting improvement for potato quality and Egyptian potato production.

Amer Eissa Ayman

2011-09-01

356

Sociodemographic factors responsible for blindness in diabetic Egyptian patients  

Directory of Open Access Journals (Sweden)

Full Text Available Khaled Gamal Ibraheem Abueleinen1, Hany El-Mekawey1, Yasser Sayed Saif2, Amr Khafagy1, Hoda Ibrahim Rizk3, Eman M Eltahlawy41Department of Ophthalmology, Cairo University, Cairo, Egypt; 2Department of Ophthalmology, Beni-Suef University, Beni-Suef, Egypt; 3Department of Public Health, Cairo University, Cairo, Egypt; 4Public Health and Community Medicine National Research Center, Cairo, EgyptPurpose: To evaluate factors behind the delay in diagnosis and treatment among Egyptian patients who present with complicated diabetic retinopathy.Methods: Observational cross-sectional study of diabetic patients with advanced diabetic retinopathy. Patients were asked to answer a questionnaire to assess the impact of several sociodemographic factors.Results: A total of 397 patients agreed to take the questionnaire. Diabetic vitreous hemorrhage was the most common ocular complication and was found in 359 patients (90.4%. A total of 158 (39.8% patients knew that diabetes mellitus can be sight threatening, while 240 (60.2% were not aware until they developed sight threatening complication. A total of 179 patients (45.1% had early retirement because of visual loss related to diabetes mellitus. Multivariate logistic regression has shown that education, internist, contact with other patients, and media were respectively significant in predicting the awareness of patients about the sight-threatening effect of diabetic retinopathy.Conclusion: Patient education regarding diabetes and diabetic eye disease is essential for early detection and compliance with treatment. Illiteracy has a significant impact on development of sight-threatening diabetic complications. The internist is the first line of prophylaxis. Media has to participate more in patient education.Keywords: blindness, education, laser photocoagulation, macular edema, vitreous hemorrhage

Abueleinen KGI

2011-11-01

357

Thyroid Disorders Associated with Alopecia Areata in Egyptian Patients  

Science.gov (United States)

Context: Alopecia areata (AA) is a common form of localized, non-scarring hair loss. The etiopathogenesis of the disease is still unclear, but the role of autoimmunity is strongly suggested. AA is commonly associated with various autoimmune disorders; the most frequent among them is autoimmune thyroid disorders. Aim: To determine whether AA is associated with thyroid autoimmunity or thyroid function abnormalities in Egyptian patients. Materials and Methods: Fifty subjects with AA (37 males and 13 females) without clinical evidence of thyroid disorders were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital, Menoufiya Governorate, Egypt, during the period from June 2009 to February 2010. They were divided into 3 groups according to severity of AA. Fifty age and sex-matched healthy volunteers (35 males and 15 females) were selected as a control group. Every case and control were subjected to history taking, complete general and dermatological examination. Venous blood samples were taken from cases and controls after taking their consents for measurement of thyroid stimulating hormone (TSH), free T3, freeT4 and detection of Anti-thyroglobulin Antibody (Tg-Ab) and Anti-thyroid Peroxidase Antibody (TPO-Ab). Results: Subclinical hypothyroidism was detected in 16% of cases. There were statistically significant differences between cases and controls regarding levels of TSH, free T3 and free T4. There were significant differences between cases and controls regarding the presence of Tg-Ab and TPO-Ab. Conclusions: Every patient with AA should be screened for thyroid functions and presence of thyroid autoantibodies even in absence of clinical manifestations suggestive of thyroid affection.

Bakry, Ola A; Basha, Mohamed A; El Shafiee, Maather K; Shehata, Wafaa A

2014-01-01

358

Atypical mycobacterial cutaneous infections in Egyptians: a clinicopathological study.  

Science.gov (United States)

Atypical mycobacteria comprise an uncommon heterogenous non-tuberculous group of acid-fast bacteria that rarely involve skin. The pattern of atypical mycobacterial cutaneous infections (AMCI) has not been previously studied in Egypt. The aim of this study was to describe the clinical characteristics, pathological features and species profile of AMCI among Egyptian patients. A retrospective study included 46 cases, diagnosed with AMCI during the period 2002 to 2012. The study included 34 males (73.9%) and 12 females (26.9%). The average age of patients was 39 years while the average duration of lesions was 15 months. The lesions were mostly located on the extremities (91.3%) and there was predominance of single (65.2%) and nodular (41.4%) lesions. History of trauma was confirmed in 91.3%. Histologically, the granulomas were mostly superficial (67.4%) with predominance of nodular suppurative pattern (84.8%). Other significant histological findings included epidermal hypertrophy (100%), presence of large-sized multinucleated giant cells (87%) and intrafollicular neutrophilic abscesses (84.8%). The diagnosis was proved by direct smear in 6.5%, skin biopsy in 10.9%, tissue culture in 47.8% and polymerase chain reaction (PCR) in 34.8%. Isolated species included Mycobacterium marinum (84.8%), Mycobacterium fortuitum (10.9%) and Mycobacterium kansasii (4.3%). Although the results of this study recommend that the diagnosis of AMCI is based mainly on culture and PCR, other clinicopathological features such as history of trauma, acral location of the lesion and suppurative granulomatous reaction with intrafollicular abscesses could be helpful clues in suspecting AMCI. PMID:24533920

El-Khalawany, Mohamed A

2014-04-01

359

Grammatical Features of Egyptian and Palestinian Arabic Heritage Speakers' Oral Production  

Science.gov (United States)

This study presents an investigation of oral narratives collected from heritage Egyptian and Palestinian Arabic speakers living in the United States. The focus is on a number of syntactic and morphological features in their production, such as word order, use of null subjects, selection of prepositions, agreement, and possession. The degree of…

Albirini, Abdulkafi; Benmamoun, Elabbas; Saadah, Eman

2011-01-01

360

Egyptian Social Studies Teachers' Responses To The Barth/Shermis Social Studies Preference Scale.  

Science.gov (United States)

Examines the interpretation of social studies found in 96 Egyptian teachers-in-training using the Barth/Shermis Social Studies Preference Scale. Results showed the subjects had not developed a meaning for social studies as conceptualized in the United States. Implications of this finding are discussed. (TRS)

Barth, James L.

1985-01-01

 
 
 
 
361

The exceptional near-infrared luminescence properties of cuprorivaite (Egyptian blue).  

Science.gov (United States)

Cuprorivaite (CaCuSi(4)O(10), also known as Egyptian blue) exhibits an exceptionally high emission quantum efficiency in the near-infrared region (lambda(max) = 910 nm, Phi(EM) = 10.5%) and a long excited state lifetime (107 mus); these properties make it appealing for several applications in the fields of biomedical analysis, telecommunications and lasers. PMID:19503881

Accorsi, Gianluca; Verri, Giovanni; Bolognesi, Margherita; Armaroli, Nicola; Clementi, Catia; Miliani, Costanza; Romani, Aldo

2009-06-21

362

On the research activities in reactor and neutron physics using the first egyptian research reactor  

International Nuclear Information System (INIS)

A review on the most important research activities in reactor and neutron physics using the first Egyptian Research Reactor (ET-RR-1) is given. An out look on: neutron cross-sections, neutron flux, neutron capture gamma-ray spectroscopy, neutron activation analysis, neutron diffraction and radiation shielding experiments, is presented

2000-11-01

363

First record of Percnon gibbesi (H. Milne Edwards, 1853) (Crustacea: Decapoda: Percnidae) from Egyptian waters  

Digital Repository Infrastructure Vision for European Research (DRIVER)

On July 2010, the invasive crab Percnon gibbesi was photographed and captured along the coast of Alexandria (Egypt, Eastern Mediterranean Sea). This represents the first observation of this species in Egyptian waters and the easternmost record for the southern rim of the Mediterranean.

Azzurro, Ernesto; Milazzo, Marco; Maynou, Francesc; Abello?, Pere; Temraz, Tarek

2011-01-01

364

Elemental concentrations in bones from an ancient Egyptian mummy and from a recent man  

International Nuclear Information System (INIS)

Differences in elemental concentrations in bones taken from an ancient Egyptian mummy and a contemporary man were investigated by using proton induced x-ray emission (PIXE) in combination with Rutherford backscattering (RBS). Remarkable differences were noticed in the Fe/Ca and Pb/Ca relative concentrations, which were consistently higher in the contemporary man. 5 refs., 2 figs., 2 tabs

1986-06-09

365

Elemental concentrations in bones from an ancient Egyptian mummy and from a recent man  

Energy Technology Data Exchange (ETDEWEB)

Differences in elemental concentrations in bones taken from an ancient Egyptian mummy and a contemporary man were investigated by using proton induced x-ray emission (PIXE) in combination with Rutherford backscattering (RBS). Remarkable differences were noticed in the Fe/Ca and Pb/Ca relative concentrations, which were consistently higher in the contemporary man. 5 refs., 2 figs., 2 tabs.

Cholewa, M.; Kwiatek, W.M.; Jones, K.W.; Schidlovsky, G.; Paschoa, A.S.; Miller, S.C.; Pecotte, J.

1986-06-01

366

Web Usage Mining Analysis of Federated Search Tools for Egyptian Scholars  

Science.gov (United States)

Purpose: This paper aims to examine the behaviour of the Egyptian scholars while accessing electronic resources through two federated search tools. The main purpose of this article is to provide guidance for federated search tool technicians and support teams about user issues, including the need for training. Design/methodology/approach: Log…

Mohamed, Khaled A.; Hassan, Ahmed

2008-01-01

367

Egyptian Court Overrules American University in Cairo's Limits on Religious Garb  

Science.gov (United States)

An Egyptian court ruled this month that the American University in Cairo could not bar a woman who wears the traditional niqab headdress from entering its library--the latest episode in the struggle between religion and secularism on Egypt's university campuses. The American University has outlawed the niqab--which covers the entire head except…

Krieger, Zvika

2007-01-01

368

Moessbauer, X-ray and derivatographic studies on Egyptian Nile clay  

International Nuclear Information System (INIS)

The constituents of the clay minerals in eighteen Nile clay and two desert (calcareous) samples, were investigated. The physicochemical transformations induced in the iron containing phases were followed by heat treatment. A conclusion was reached about the behaviour of the ferrous and ferric ions at various temperatures. This behaviour is applied to characterize the archaeological Ancient Egyptian pottery. (orig.)

1988-02-01

369

Cats of the Pharaohs: Genetic Comparison of Egyptian Cat Mummies to their Feline Contemporaries.  

Science.gov (United States)

The ancient Egyptians mummified an abundance of cats during the Late Period (664 - 332 BC). The overlapping morphology and sizes of developing wildcats and domestic cats confounds the identity of mummified cat species. Genetic analyses should support mummy identification and was conducted on two long bones and a mandible of three cats that were mummified by the ancient Egyptians. The mummy DNA was extracted in a dedicated ancient DNA laboratory at the University of California - Davis, then directly sequencing between 246 and 402 bp of the mtDNA control region from each bone. When compared to a dataset of wildcats (Felis silvestris silvestris, F. s. tristrami, and F. chaus) as well as a previously published worldwide dataset of modern domestic cat samples, including Egypt, the DNA evidence suggests the three mummies represent common contemporary domestic cat mitotypes prevalent in modern Egypt and the Middle East. Divergence estimates date the origin of the mummies' mitotypes to between two and 7.5 thousand years prior to their mummification, likely prior to or during Egyptian Predyanstic and Early Dynastic Periods. These data are the first genetic evidence supporting that the ancient Egyptians used domesticated cats, F. s. catus, for votive mummies, and likely implies cats were domesticated prior to extensive mummification of cats. PMID:22923880

Kurushima, Jennifer D; Ikram, Salima; Knudsen, Joan; Bleiberg, Edward; Grahn, Robert A; Lyons, Leslie A

2012-10-01

370

A synthetic radiological study of brain treatment in ancient Egyptian mummies.  

Science.gov (United States)

Variability in brain treatment, as a part of the Egyptian mummification process, is poorly appreciated in the literature, as variability in the details of excerebration have not been addressed comprehensively nor with respect to social, geographic, and temporal variation. The description of Egyptian mummification commonly used in the popular and academic literature is derived largely from accounts by Herodotus and Diodorus Siculus. However, this normative description does not acknowledge the existence of a wide range of mummification techniques practiced and so stifles the study of geographic and chronological changes in the practice and their causes. Therefore, the goal of this study is to use the classical description as a hypothesis for empirical testing, using published literature and primary radiographic data, with a specific focus on the practice of excerebration. Three primary treatments of the brain in mummification, and their variation over time and across social strata, are discussed in relation to their treatment in the literature, their radiological indicators, and their technical considerations. In order to examine Egyptian mummy excerebration, this study makes use of two samples: (1) a literature-based sample of 125 mummies, and (2) a sample of 6 mummies examined directly using computed tomography. In spite of an apparent high degree of variability, the literature continues to focus on modern and classical stereotypes rather than the rich variability in the Egyptian mummification tradition. Detailed, large-scale examination of this and other mummification traditions, and their meanings, is required to further our understanding of this important early complex society. PMID:21481868

Wade, Andrew D; Nelson, Andrew J; Garvin, Greg J

2011-08-01

371

Genetic drift. The ancient Egyptian dwarfs of the pyramids: the high official and the female worker.  

Science.gov (United States)

The existence of dwarfism is amply documented in ancient Egypt due to the rich biological and artistic legacies. In previous articles published in this journal, I discussed the roles of people with skeletal dysplasia in ancient Egyptian civilization. In this article I, along with my Egyptian and American colleagues, describe two skeletons of dwarfs that date to 2700-2184 BCE and were unearthed from a funerary complex near the Great Pyramids in Giza. The first skeleton belongs to a high official, Per-ni-ankh-w, who died between 45 and 50 years of age. His statue is on display in the Egyptian Museum of Cairo. The second skeleton belongs to a pregnant female worker found with a fetus in situ. Her estimated age at death was 25-30 years. She most likely died during childbirth due to a small pelvic outlet as supported by her narrow sacrum. The fetal bones appear normal. Radiological examination of both skeletons confirmed the clinical diagnosis of achondroplasia. Ancient Egyptians concerned themselves with the search for spiritual fulfillment through the tradition of moral teachings. Amenemope, a wise man who lived during the reign of Amenhotep III (1391-1354 BCE), advocated respect toward individuals with disabilities: Do not jeer at a blind man nor tease a dwarf, Neither interfere with the condition of a cripple. Do not taunt a man who is in the hand of God, Nor scowl at him if he errs. In summary, artistic, biological, and written resources indicate that dwarfs were well integrated in ancient Egyptian society. PMID:21674771

Kozma, Chahira; Sarry El Din, Azza Mohamed; El Shafy El Banna, Rokia Abd; El Samie Kandeel, Wafaa Abd; Lachman, Ralph

2011-08-01

372

Phenolic content of some selected Lamiaceous Egyptian medicinal plants: antioxidant potential and ecological friend mosquito-larvicldal.  

Science.gov (United States)

Phenol compounds are naturally occurring biologically active compounds existing in all plants had received major medical concern so development in research focused on their extraction, identification and quantification have occurred over the last 25 years; they constitute an important source of antioxidants and were used to help human body to reduce oxidative damage. Mosquitos-borne diseases constitute one of the major health problems worldwide. Control strategies involving pinpointing natural ecological friend, cheap and safe mosquitocides, mainly larvicides to stop their life cycle. Quantitative estimation of total phenol, flavonoids, phenylethanoid and iridoid contents of sixteen selected Lamiaceous Egyptian plants for screening of their antioxidant and mosquito larvicidal effects was carried out. The results showed that the most suitable medicinal plants used as antioxidants were Lavendula dentata L., Thymus capitatus L. and Thymus bovei Benth., which contain adequate mixture of total phenol, flavonoid and phenylethanoid contents, with distinct larvicidal effect in a descending order was T. capitatus L., T. bovei Benth. and L. dentata L. by their adequate mixture of total phenol, flavonoid, iridoid and phenylethanoid glycoside content. PMID:24961008

Abdel-Hady, Nevein M; El-Hela, Atef A; Morsy, Tosson A

2014-04-01

373

On the astronomical orientation of the IV dynasty Egyptian pyramids and the dating of the second Giza pyramid  

CERN Document Server

The data on the astronomical orientation of the IV dynasty Egyptian pyramids are re-analyzed and it is shown that such data suggest an inverse chronology between the `first` and the `second` Giza pyramid.

Magli, G

2003-01-01

374

Isolation and identification of microorganisms and antibacterial activity of Laban Zeer, an Egyptian traditional fermented milk product  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Laban Zeer is a traditional Egyptian fermented milk product. The microorganisms of Laban Zeer were isolated and identified to species level, as well as the antibacterial activity of Laban Zeer was also studied against pathogenic bacteria. Total viable microorganisms, inclu...

2013-01-01

375

Predictors of postpartum depression in a sample of Egyptian women  

Directory of Open Access Journals (Sweden)

Full Text Available El-Sayed Saleh,1 Wafaa El-Bahei,1 Mohamed Adel El-Hadidy,1 Abdelhady Zayed21Psychiatric Department, 2Gynecological and Obstetric Department, Mansoura Faculty of Medicine, Mansura University, Mansoura, EgyptIntroduction: Postpartum depression (PPD represents a considerable health problem affecting women and their families. The aims of this study were to: (a compare female patients with PPD to normal controls with regard to some biopsychosocial variables, (b correlate between the severity of PPD and some clinical and biological variables, and (c to predict some risk factors for PPD.Method: Sixty female patients with PPD were compared with 60 healthy postpartum females (control group. Patient and controls were subjected to: (1 a complete psychiatric and obstetric examination, (2 psychometric studies using the Edinburgh Postnatal Depression Scale, Fahmy and El-Sherbini's Social Classification Scale for Egyptian socioeconomic classification and Horowitz et al's Impact of Event Scale, (3 quantities of thyroid hormone (T3, cortisol hormone, and estrogen were assessed.Results: There were high statistical differences between PPD females and controls as regard psychosocial stressors, level of (estradiol, thyroxin [T3], and cortisol, marital status, residence, parity, method of delivery, complicated puerperium, positive history of premenstrual tension syndrome and baby variables (eg, unwelcomed, with a negative attitude of parents toward the baby, underweight, female, artificially feeding, unhealthy baby. While there were moderate statistical differences in attitude toward spouse and social support and mild statistical difference in socioeconomic status between them. Severity of depression is positively highly correlated with onset of depression, psychosocial stress, levels of T3 and cortisol. However, severity of depression is negatively high when correlated with socioeconomic status. Stepwise linear regression indicated that PPD was significantly predicted by social support, socioeconomic status, feeding of baby, and prior psychiatric problems.Conclusion: Many factors may lead to development of PPD. These factors include some psychosocial, socioeconomic, obstetric, and hormonal variables. Early detection of these factors could help in prediction of the development of PPD.Keywords: mood, hormone, delivery, socioeconomic

Saleh ES

2012-12-01

376

Intra-familial physical violence among Mexican and Egyptian youth Violência física intra-familiar entre jovens mexicanos e egípcios  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVE: To determine the prevalence of experiencing intra-familial violence among Mexican and Egyptian youth and to describe its associated risk factors. METHODS: Data from questionnaires applied to 12,862 Mexican and 5,662 Egyptian youth, aged 10 to 19, who attended public schools were analyzed. Biviarate and logistic regression analysis were used to determine the relationship between socio-demographics, the experience of intra-familial violence and violence perpetration. RESULTS: The pre...

Leonor Rivera-Rivera; Betania Allen; Thrasher, James F.; Ruben Chavez; Cielo Fernandez-Ortega; Osman Galal; Lazcano-ponce, Eduardo C.

2005-01-01

377

Evaluation of hemoglobinopathy screening results of a six year period in Turkey '  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Objectives: Hemoglobinopathies are autosomal recessive inherited diseases more commonly seen in Mediterranean countries. Hereditary blood diseases including B-thalassemia and sickle cell anemia are important health problems. In our study we aimed to analyze the results of the premarital hemoglobinopathy screening test for a 6 years period in Hatay region. Material and Methods: The study sample comprised the couples attending to the Mother and Child Health Care Center in Hatay for premarital hemoglobinopathy screening from 2004 to 2009. Hemoglobin chain analyses of 87.830 couples were evaluated. RESULTS: 175.660 people were screened at total. The prevalence of beta thalassemia trait, sickle cell anemia trait, sickle cell anemia, beta thalassemia major, beta-thalassemia intermedia, alpha-thalassemia, alpha-thalassemia trait was found as 13.921 (7,9%, 6.074 (3,4%, 631 (0.35%, 132 (0.07%, 118 (0.06%, 9 (0.005%, 150 (0.08% respectively. 72 newborns with beta-thalassemia were diagnosed as a result of the marriage of the carrier couples in 6 years. Conclusions: Hatay is a high risk region for beta-thalassemia and sickle cell anemia trait. In countries with high prevalence of hemoglobinopathies, a premarital screening program and counseling is needed to decrease the prevalence.

Seçil Gunher Ar?ca

2012-02-01

378

Metabolism and excretion of leptophos and its phenol in S and R larvae of the Egyptian cotton leafworm.  

Science.gov (United States)

The metabolism and excretion of leptophos, 0-(4-bromo-2,5 dichlorophenyl) 0-methyl phenylphosphonothioate, and its phenol, 4-bromo-2,5-dichlorophenol, were examined in susceptible (S) and leptophos resistant (R) strains of the Egyptian cotton leafworm Spodoptera littoralis (Boisd.). Leptophos injected into the larvae is converted in vivo into at least five chloroform-soluble and two water-soluble products. Minor qualitative differences were observed between S and R larvae. Quantitatively, the disappearance of leptophos was faster in R (t1/2 = 2.5 hr) than in S (t1/2 = 21.5 hr) larvae. A small amount of leptophos oxon (2 to 7%) was detected in S larvae, but none in R larvae. The major degradation product was the free phenol and its amount was relatively higher in R (17 to 22%) than in S (5 to 5%) larvae. After 24 hr, 25% of the injected leptophos was excreted unchanged by R larvae, whereas less amount (15%) was excreted by S larvae. However, the amount of excreted phenol, in free form, by S and R larvae was almost equal (5 to 8%). Following injection of the phenol derivative, its disappearance was faster in S (t1/2 = 36 min) than in R (t1/2 = 72 min) larvae, whereas phenol excretion, 24 hr after injection, was significantly higher by R (37%) than by S (9%) larvae. PMID:6178375

Riskallah, M R; Esaac, E G

1982-01-01

379

Patterns of ovarian and oestrous activity and induction of cyclic activity during the post-partum period in Egyptian buffaloes  

International Nuclear Information System (INIS)

This report covers three studies. In the first study, ovarian and oestrous activity were monitored in 47 buffaloes for 90 days following parturition. Failure to resume ovarian cyclicity after calving was found to be the main reason for the delay in conception. High incidence of ovulatory anoestrus (64%) constitutes also a major problem in Egyptian buffaloes. In the second study, buffaloes with inactive ovaries were treated at 90 days post-partum with either GnRH or progesterone, given either intravaginally (PRID) or orally (CAP). Both GnRH and PRID were effective in inducing ovulation but GnRH administration was followed by a high incidence of silent ovulation. Within the 35 days following treatment, about 50% of the PRID treated animals got in calf vs. 44 and 22% for GnRH and CAP treated animals, respectively. In the third study, buffaloes were treated with either 6 or 12?g GnRH at either 7 or 15 days post-partum. GnRH treatment resulted in significant reductions in the intervals from calving to first ovulation, first detected oestrus and time to first rise in serum progesterone concentration (> 1 ng/mL). (author). 26 refs, 5 figs, 4 tabs

1987-03-23

380

The Prevalence of Vitamin D Deficiency in Ancient Egyptian Population from Baharia Oasis, the Greco Roman Period  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Vitamin D deficiency is considered to be the most common nutritional deficiency and also one of the most common undiagnosed medical conditions in the world. Vitamin D is naturally present only in minor amounts in most foods; the great majority is synthesized by the action of ultraviolet light on chemical precursors in the skin. The manifestation of vitamin D deficiency in sub adults is referred to as rickets, and in adults, osteomalacia . Rickets and osteomalacia are the sub adult and adult expressions of a disease in which the underlying problem is a failure to mineralize bone protein (osteoid. The most common cause of this disease is a physiological deficiency in vitamin D. The associated problems include deformed bones. Material and Methods: This study aimed to investigate the skeletal remains of ancient Egyptians from Baharia Oasis population for lesions indicative of vitamin D deficiency (rickets and osteomalacia. The material consisted of 1075 commingled bones (38 sub adults and1037 adults. They were recovered from Baharia oasis. Results: The results showed that, there was no evidence of rickets in sub adult group. The prevalence of osteomalacia in adult Baharia populations was 7.4% ; all were adult males. This result could indicate that this population was subjected to sunlight all over the year and their diet was rich of calcium and phosphorus. Conclusion: These few cases that were found may be due to mechanical stress during wine and textile production.

Rokia Abd ElShafy Soliman El-Banna*, , Azza Mohamed Sarry El-Din*, Fatma Ahmed Eid**, Walaa Yousef Mohamed Ali

2014-04-01

 
 
 
 
381

General description and production lines of the Egyptian fuel manufacturing pilot plant  

International Nuclear Information System (INIS)

The Egyptian Fuel Manufacturing Pilot Plant, FMPP, is a new facility, producing an MTR-type fuel elements required for the Egyptian Second Research Reactor, ETRR-2, as well as other plates or elements for an external clients with the same type and enrichment percent or lower, (LEU). General description is presented. The production lines in FMPP, which begin from uranium hexaflouride (UF6, 19.7±0.2 % U235 by wt), aluminum powder, and nuclear grade 6061 aluminium alloy in sheets, bars, and rods with the different heat treatments and dimensions as a raw materials, are processed through a series of the manufacturing, inspection, and quality control plan to produce the final specified MTR-type fuel elements. All these processes and the product control in each step are presented. The specifications of the final product are presented. (author)

1999-10-26

382

Characterization of pigments and colors used in ancient Egyptian boat models  

Energy Technology Data Exchange (ETDEWEB)

The analyses of pigments originating from well dated ancient boat models found in Egyptian graves were used for characterization and for dating tasks of unknown objects. A nearly destruction free sampling technique using cotton buds was applied for sampling these valuable artifacts for a subsequent Total Reflection X-Ray Fluorescence Spectrometry (TXRF) analysis. Two relevant collections of Egyptian object of art were at our disposal, one of the Agyptisches Museum Berlin and the second of the British Museum London. Three groups of colors were studied, they originate from white, red and blue/green paints, respectively. The results of the analyses performed on micro-amounts of paints (< 1 {mu}g) show that some artifacts were misclassified and belong to other epochs. Some others were retouched with modern colors. In general, it can be stated that results obtained by Total Reflection X-Ray Fluorescence Spectrometry may dissipate some uncertainties when applying classical archaeological dating methods.

Huehnerfuss, Katja [Archaeologisches Institut, Universitaet Hamburg, Johnsallee 35, 20148 Hamburg (Germany); Bohlen, Alex von [ISAS - Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, 44139 Dortmund (Germany)]. E-mail: vonbohlen@isas.de; Kurth, Dieter [Archaeologisches Institut, Universitaet Hamburg, Johnsallee 35, 20148 Hamburg (Germany)

2006-11-15

383

Characterization of pigments and colors used in ancient Egyptian boat models  

Science.gov (United States)

The analyses of pigments originating from well dated ancient boat models found in Egyptian graves were used for characterization and for dating tasks of unknown objects. A nearly destruction free sampling technique using cotton buds was applied for sampling these valuable artifacts for a subsequent Total Reflection X-Ray Fluorescence Spectrometry (TXRF) analysis. Two relevant collections of Egyptian object of art were at our disposal, one of the Ägyptisches Museum Berlin and the second of the British Museum London. Three groups of colors were studied, they originate from white, red and blue/green paints, respectively. The results of the analyses performed on micro-amounts of paints (< 1 ?g) show that some artifacts were misclassified and belong to other epochs. Some others were retouched with modern colors. In general, it can be stated that results obtained by Total Reflection X-Ray Fluorescence Spectrometry may dissipate some uncertainties when applying classical archaeological dating methods.

Hühnerfu?, Katja; von Bohlen, Alex; Kurth, Dieter

2006-11-01

384

Behaviour of some acid-base indicators in some Egyptian aquatic environments  

International Nuclear Information System (INIS)

The dissociation constants of some selected acid-base indicators (methyl red, bromothymol blue, bromo cresol green) were evaluated in some Egyptian aquatic environments. The studied regions included marine (seven sites along the Egyptian Mediterranean coast from Abu-Qir east of Alexandria to the region of 21 km west of Alexandria), lakes (Mariut, Edku, and Burullus) and the drainage system around Alexandria (El-Kalaa, El-Umum, Barsiek and El-Khairy Drains and El-Noubaria Draining canal). Two samples were collected from the fishing ponds El-Nozha Hydrodrome and El-Mex. Some physical and chemical characteristics of the aquatic systems were determined and discussed. The behavior of the indicators is correlated with their structure and the status of the environment. (Author)

2004-01-01

385

Characterization of pigments and colors used in ancient Egyptian boat models  

International Nuclear Information System (INIS)

The analyses of pigments originating from well dated ancient boat models found in Egyptian graves were used for characterization and for dating tasks of unknown objects. A nearly destruction free sampling technique using cotton buds was applied for sampling these valuable artifacts for a subsequent Total Reflection X-Ray Fluorescence Spectrometry (TXRF) analysis. Two relevant collections of Egyptian object of art were at our disposal, one of the Agyptisches Museum Berlin and the second of the British Museum London. Three groups of colors were studied, they originate from white, red and blue/green paints, respectively. The results of the analyses performed on micro-amounts of paints (< 1 ?g) show that some artifacts were misclassified and belong to other epochs. Some others were retouched with modern colors. In general, it can be stated that results obtained by Total Reflection X-Ray Fluorescence Spectrometry may dissipate some uncertainties when applying classical archaeological dating methods

2006-11-01

386

Cardiac and Liver T2* Measurement in 2000 Thalassemia Patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

"nIntroduction: Although several studies have been published for the evaluation of  myocardial and hepatic iron loads and serum ferritin levels in beta - thalassemia major patients, most of them are reported in small series. The purpose of this study is to evaluate these parameters in a larger group of patients. "nMaterial and Methods: One thousand and five hundred and eighty eight beta thalassemia major patients with the mean age of 23.5 (SD=9.4) years were enrolled in this st...

Shahram Akhlaghpoor; Mohammadreza Alinaghizadeh; Mansoor Fatehi; Abbas Arjmand Shabestari; Amir Hossein Jafari; Afshan Shirkavand

2009-01-01

387

A rapid instrumental neutron activation method for multielement content of some Egyptian phosphate minerals  

International Nuclear Information System (INIS)

An instrumental neutron activation analysis technique has been applied to some Egyptian phosphate minerals. The following 24 elements have been quantitatively determined. Sc, Cr, Fe, Co, As, Sr, Zr, Nb, Ag, Sn, Te, Ba, La, Ce, Nd, Eu, Tb, Ho, Yb, Lu, Hf, Ta, Ir and U. The observed distribution and abundance of some of the above elements could help in the proper evaluation of conditions of deposition and origin of their phosphate minerals

1979-01-01

388

Prevalence of occult hepatitis C in egyptian patients with non alcoholic fatty liver disease  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This study aim is to assess the prevalence of occult HCV infection among Egyptian patients with non alcoholic fatty liver disease (NAFLD) with elevated AST and ALT, and to correlate presence of occult HCV with severity of liver disease. Patients and Methods: After informed consent 27 patients with elevateed liver enzymes diagnosed as NAFLD were examined for demographic, clinical, laboratory data and Ultrasonography. Liver biopsy was done and tested for HCV RNA in tissue. Genotyping using RFLP...

Yasmin Saad; Soheir Zakaria; Iman Ramzy; Maissa El Raziky; Olfat Shaker; Wafaa elakel; Mohamed Said; Mona Noseir; Mai El-Daly; Mohamed Abdel Hamid; Gamal Esmat

2011-01-01

389

Visual function of Egyptian children with low vision and the demographic determinants  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Aims: To determine whether the LV Prasad-Functional Vision Questionnaire (LVP-FVQ) could be used to assess self-reported visual function and quality of visual life in Egyptian school aged children. Materials and Methods: The LVP-FVQ was used to assess the quality of visual function in school-age children. All subjects were students at the time of assessment. Subjects underwent a visual function assessment that included distance and near visual acuity, contrast sensitivity, color vision and vi...

2010-01-01

390

Effect of selected natural dyes in reduction on colour changes of Egyptian linen textiles by fungi.  

Science.gov (United States)

Linen is the most historical Egyptian textile fibre liable to fungal deterioration. Fungal deterioration of dyed linen textiles may appear as undesirable different stains. In order to success in removing of fungal stains from biodeteriorated historical Egyptian dyed linen textiles, it is necessary to understand the nature and causes of these stains, hence their subsequent removal. So this paper aims to investigate the effect of fungi on dyed linen textiles. In this study linen textile samples were experimentally dyed by two different dyes, blue one as an example to vat dye and yellow one as an example to direct dye. This work is done on two of the most important dyes (Turmeric and indigo), which were popular in most of historical periods in Egypt. Dyed linen samples were experimentally biodegraded by thirty different fungal strains isolated previously from historical Egyptian linen samples. The produced change in colours of the biodeteriorated samples was detected visually. Also, the change in reflection spectra and colour differences produced to dyed linen textiles after fungal deterioration, were assessed and evaluated by using spectrophotometer. This study reported that most of tested fungi contribute to discoloration of all tested dyed linen samples. These results indicate that most of stains on historical Egyptian dyed linen textiles, may be fungal stains. The results confirm that undyed linen textiles more liable to fungal biodeterioration than dyed ones. Also the results show that yellow dyed linen textiles are more susceptible to fungal deterioration than blue dyed linen textiles. The obtained results show that Alternaria tenuissima, Chaetomium globosum, Chaetomium sp., Penicillium raistrickii, P. soppi, P. asperum, P. citrinum, Aspergillus carbonarius, A. fischeri, A. nidulans, A. terreus and A. niger, had showed the maximum colour changes of the deteriorated yellow dyed linen samples. The results also show that Alternaria tenuissima, Chaetomium sp., Penicillium asperum, P. citrinum, Aspergillus nidulans and A. spinulosus, had shown the maximum colour changes of the deteriorated blue dyed linen samples. PMID:17867537

Abdel-Kareem, Omar

2007-07-01

391

Compensating Differentials and the Value of Job Security: Evidence from the Egyptian Public Sector  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This paper considers the determinants of male and female pay in the public and private sectors by estimating a joint model of sector allocation and wage determination using cross-sectional data from the Egyptian 1987 and 1997 labour force surveys. A model of compensating wage differentials is defined and estimated, in order to quantify the value of arguably the three most important non-pecuniary aspects of public sector employment: job security, fringe benefits (especially comprehens...

Mona Said

2011-01-01

392

Oxalate Content of Egyptian Grown Fruits and Vegetables and Daily Common Herbs  

Directory of Open Access Journals (Sweden)

Full Text Available Egyptian dieticians typically rely on foreign databases to find out oxalate content of food due to unavailability of local databases. The soil, fertilizers, climate and cultivars are often very different. Therefore, the purpose of this study is to establish a local database of oxalate content in Egyptian grown fruits and vegetables and selected daily common herbs. The current study analysed the total and the soluble oxalate in 37 Egyptian grown fruits, vegetables and 9 commonly used herbs. Two methods were used for screening the Egyptian foods for oxalate concentration; the first method was AOAC 1999 and the second was enzymatic method. Total oxalate varied greatly among the vegetables examined, ranging from 4 to 917 mg/100 g F.W. Total oxalate of analysed fruits ranged from 9 to 50 mg/100 g F.W. There is a strong correlation found between the two methods used. Vegetables were classified into 4 categories; low oxalate concentration containing less than 10 mg of oxalic acid /100 g F.W., such as cabbage, courgette, cucumbers, garlic, spring onions and turnip. Moderate oxalate concentration vegetables containing 10-25 mg/100 g F.W., such as aubergine, field bean, corn, peppers and watercress. High oxalate concentration vegetables containing 26-99 mg/100g F.W., such as ful, green beans, celery, mallow, okra and sweet potatoes. Very high oxalate concentration containing 100-900 mg/100g F.W. such as Swiss chard, molokhia, purslane and vine leaves (fresh. Extensive amounts of total oxalate (201-4014 mg/100 g D.W. were found in daily common herbs such as caraway seed, green cardamom, cinnamon, coriander seeds, cumin, curry powder, ginger and turmeric powder.

Aly R. Abdel-Moemin

2014-03-01

393

The Egyptian Dialect as an Expression of Linguistic Change in Arab Countries  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In this article I am going to present the ways in which the Egyptian dialect renders social norms which are illustrated by the examples of expressions regarding human-to- human interaction. This provides an outline of the existent system of values with special emphasis laid upon the values of collectivism and individualism (perceived in the categories of cross-cultural psychology). Within the framework of collectivism the expressions are shaped in the field of tribal and family life owing to ...

Machut-mendecka, Ewa

2011-01-01

394

Body image disturbance and surgical decision making in egyptian post menopausal breast cancer patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background In most developing countries, as in Egypt; postmenopausal breast cancer cases are offered a radical form of surgery relying on their unawareness of the subsequent body image disturbance. This study aimed at evaluating the effect of breast cancer surgical choice; Breast Conservative Therapy (BCT) versus Modified Radical Mastectomy (MRM); on body image perception among Egyptian postmenopausal cases. Methods One hundred postmenopausal women with...

2009-01-01

395

3-D reconstruction of an ancient Egyptian mummy using X-ray computer tomography.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Computer tomography has been used to image and reconstruct in 3-D an Egyptian mummy from the collection of the British Museum. This study of Tjentmutengebtiu, a priestess from the 22nd dynasty (945-715 BC) revealed invaluable information of a scientific, Egyptological and palaeopathological nature without mutilation and destruction of the painted cartonnage case or linen wrappings. Precise details on the removal of the brain through the nasal cavity and the viscera from the abdominal cavity w...

Baldock, C.; Hughes, S. W.; Whittaker, D. K.; Taylor, J.; Davis, R.; Spencer, A. J.; Tonge, K.; Sofat, A.

1994-01-01

396

Genetic Variation Among Egyptian Cultivars of Vicia faba L.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Nine Egyptian cultivars of Vicia faba were analyzed using electrophoretic and quantitative data from seed albumins and globulins and 100 seeds weight to measure genetic variation among faba bean cultivars in Egypt. Wide genetic variation was indicated for all the traits studied. The elctrophoregrams showed identity profile for each cutivar supporting the validity of electrophoresis of seed protein components in cultivar identification and assessing genetic variation in Vicia faba

2007-01-01

397

Multiplex PCR for Detection of Diarrheagenic Escherichia coli in Egyptian Children  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Diarrheal diseases continue to be one of the most common causes of morbidity and mortality among young children in developing countries. The objectives of this study were to evaluate the multiplex PCR as a rapid diagnostic tool for simultaneous detection of 3 categories of diarrheagenic E. coli (ETEC, EPEC, EHEC) in one PCR reaction using 6 virulent genes; to determine the prevalence of these 3 categories among Egyptian children with and without diarrhea and get an idea about their ant...

El Metwally, Hala A. R.; Ibrahim, Hoda A. H.; El-athamna, Marwa N.; Amer, Maysa A.

2007-01-01

398

Changes in composition of colostrum of Egyptian buffaloes and Holstein cows  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Changes in colostrum composition of Egyptian buffaloes and Holstein cows collected at calving, 6, 12, 24, 48, 72, 96, 120 h and after 14 days of parturition were studied. Total solids, total protein, whey proteins, fat, lactose and ash contents were determined. Macro- and micro-elements, IgG, IgM, IGF-1, lactoferrin and vitamins (A and E) were also estimated. Results At calving, the total protein and whey proteins concentration did not differ...

Abd El -Fattah Alaa M; Hr, Abd Rabo Fawzia; EL-Dieb Samia M; El-Kashef Hany A

2012-01-01

399

Preparation of precipitated barium sulphate from Egyptian barytes ore and its application in paints  

International Nuclear Information System (INIS)

Precipitated barium sulphate (Blank fixe) was prepared and evaluated as an extender pigment, making use of the naturally occurring Egyptian barytes ore. X-ray diffraction patterns, transmission electron microscope, thermal gravimetric analysis, color measurements, specific gravity, oil absorption, bulking value, bleed resistance, hydrogen ion concentration, permanence for light and heat and chemical resistance were different methods used for characterization and evaluation of the prepared pigment. Medium oil alkyd resin, melamine-alkyd and epoxy resin were used as different binding media for the application and testing of the prepared pigments as an extender- in some paint formulations, this was done in comparison with a commercial imported blank fixe sample and the Egyptian barytes ore that it was prepared from. It was found that; a white bright fine powder of precipitated barium sulfate could be successfully prepared from the locally abundant Egyptian barytes ore. It has a suitable properties as an extender pigment. Paints pigmented with blank fixe offered favourable rheological and protective properties exceeding that of the imported commercial sample and the ore that was prepared from

2005-11-27

400

A Critical Discourse Analysis of Discursive (De- Legitimation Construction of Egyptian Revolution in Persian Media  

Directory of Open Access Journals (Sweden)

Full Text Available This article seeks to explore discursive strategies applied in Fars News to represent the event of Egyptian revolution as a positive/legitimized action and Hosni Mubarak’s regime as the negative/delegitimized other. Van Leeuwen's (2008 model of legitimation is used to show how Fars News applies the legitimation discursive construction, including four main categories of ''authorization'', ''evaluation'', ''rationalization'', and ''mythopoesis'' to legitimize Egyptian revolution.  This article also tries to see how this news agency tries to delegitimize Mubarak’s regime by using such discursive strategies. The researchers aim to reveal how Fars News network is using language in order to legitimize or delegitimize a single event. Also, the research will argue how using certain discursive strategies of language can affect people’s mind in a way that might be in line with the policies and guidelines of a specific news agency. The study shows that Fars News put more focus on legitimizing Egyptian revolution than delegitimizing Hosni Mubarak's regime, and for the purpose of persuading its audiences to take the revolution as a good event and Mubarak as the evil since it has mostly utilized ''authorization" as the most influential legitimating category. And among the subcategories of legitimation, Fars News has made use of "personal authority" more frequently. 

Bahador Sadeghi

2013-09-01

 
 
 
 
401

Prune belly syndrome in an Egyptian infant with Down syndrome: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Introduction Prune belly syndrome is a rare congenital anomaly of uncertain aetiology almost exclusive to males. The association between prune belly syndrome and Down syndrome is very rare. Case presentation A 4-month-old Egyptian boy was admitted to our institute for management of acute bronchiolitis. He was born at full term by normal vaginal delivery. His mother, a 42-year-Egyptian villager with six other children, had no antenatal or prenatal care. On examination, the boy was found to be hypotonic. In addition to features of Down syndrome, karyotyping confirmed the diagnosis of trisomy 21. Ultrasound examination of the abdomen showed bilateral gross hydronephrosis with megaureter. Micturating cystourethro