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Sample records for egyptian beta-thalassemia major

  1. Glutathione S-transferase gene polymorphism: Relation to cardiac iron overload in Egyptian patients with Beta Thalassemia Major.

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    Mokhtar, Galila M; Sherif, Eman M; Habeeb, Nevin M; Abdelmaksoud, Abeer A; El-Ghoroury, Eman A; Ibrahim, Ahmed S; Hamed, Enas M

    2016-01-01

    Objectives Estimating the prevalence of glutathione S-transferase gene polymorphism (GSTM1) null genotype among patients with beta thalassemia major (?-TM) in relation to myocardial status assessed by tissue Doppler and cardiac siderosis assessed by cardiac magnetic resonance imaging (MRI) T2*. Methods Hundred patients with ?-TM and 100 healthy controls were enrolled. Complete blood count (CBC), mean serum ferritin and GSTM1 genotyping, echocardiography, tissue Doppler, and cardiac MRI T2* were done. Results Serum ferritin ranged from 1200 to 8000 ng/ml, and mean T2* value was 27.10 ± 11.20 ms. Of patients, 68 (68%) had no cardiac siderosis, while 24 (24%) with mild to moderate, and 8 (8%) with sever cardiac siderosis. T2* values were not correlated with serum ferritin (r = -0.09, P = 0.50). GSTM1 null genotype was prevalent in 46% of patients and 40% of controls (P = 0.69). Patients with null genotype had significantly shorter T2* (P = 0.001), higher left ventricular end-diastolic diameter (P = 0.002), and shorter ejection time (P = 0.005) with no significant relation to serum ferritin (P = 0.122). GSTM1 null genotype was the only predictor for cardiac iron overload (P = 0.002). Discussion Serum ferritin concentrations have been shown to correlate poorly with all stages of cardiac dysfunction. Low cardiac MRI T2* values occur in patients with ?-TM despite good chelation therapy, suggesting a possible role of genetic factors in cardiac siderosis. Conclusion GSTM1 null genotype is significantly associated with cardiac iron overload independent of serum ferritin in Egyptian patients with ?-TM. PMID:26288192

  2. Gradient-echo magnetic resonance imaging study of pancreatic iron overload in young Egyptian beta-thalassemia major patients and effect of splenectomy

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    Matter Randa M

    2010-04-01

    Full Text Available Abstract Background Thalassemic patients suffer from diabetes mellitus secondary to hemosiderosis. Aims The study aimed to evaluate pancreatic iron overload by T2*-weighted Gradient-echo magnetic resonance imaging (MRI in young beta-thalassemia major patients and to correlate it with glucose disturbances, hepatic hemosiderosis, serum ferritin and splenectomy. Methods Forty thalassemic patients (20 non diabetic, 10 diabetic, and 10 with impaired glucose tolerance were recruited from Pediatric Hematology Clinic, in addition to 20 healthy controls. All patients underwent clinical assessment and laboratory investigations included complete blood count, liver function tests, serum ferritin and oral glucose tolerance test (OGTT. A T2*-weighted gradient-echo sequence MRI was performed with 1.5 T scanner and signal intensity ratio (SIR of the liver and the pancreas to noise were calculated. Results Significant reduction in signal intensity ratio (SIR of the liver and the pancreas was shown in thalassemic patients compared to controls (P Conclusions pancreatic siderosis can be detected by T2* gradient-echo MRI since childhood in thalassemic patients, and is more evident in patients with abnormal glucose tolerance. After splenectomy, iron deposition may be accelerated in the pancreas. Follow up of thalassemic patients using pancreatic MRI together with intensive chelation therapy may help to prevent the development of overt diabetes.

  3. Malocclusion in subjects with beta-thalassemia major

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    F. Shahsevari

    2007-08-01

    Full Text Available Introduction: Introduction: Beta-thalassemia major is a hemolytic anemia. If these patients are not treated, bone marrow hyperplasia will happen. Hematopoiesis in the jaw results in mandibular and/or maxillary enlargement. To our knowledge, there are few studies about frequency of malocclusion in these patients. Therefore, this study was designed to investigate the frequency of malocclusion in beta-thalassemia patients and compare it to healthy control group. Materials and Methods: This research was a cross sectional study. Seventy beta-thalassemia patients and 70 healthy controls (age and sex matched were examined for malocclusion using Angle classification, WHO malocclusion classification, determination of overjet and overbite. If crossbite, spacing, openbite, crowding and mouth breathing were observed in clinical examination they were recorded. Statistical analysis was done using Chi-square and Variants analysis. Results: Beta-thalassemia patients showed class II malocclusion (angle classification and grade 2 (WHO classification more than healthy control group. There were significant differences in angle & WHO malocclusion classification between two groups (P<0.05. Increased overjet and mouth breathing were seen in patients more than healthy control group. There were significant differences in overjet and mouth breathing between two groups (P<0.05. There was a positive correlation between WHO malocclusion classification and serum ferritin levels, but not between angle malocclusion classification, overjet and serum ferritin levels. Conclusion: Beta-thalassemia major is associated with increased malocclusion and these anomalies will occur if the patients are not treated early. Patients with malocclusion should be visited and followed up by a dentist for dental problems. Fortunately, as a result of new treatments these patients live longer than before. Therefore, it is important to pay attention to their functional and esthetical problems.

  4. Skeletal Changes in Patients with Beta –Thalassemia Major in Ahvaz

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    Mashaalah Khanehmasjedi

    2012-08-01

    Full Text Available Background and Objective: Thalassemia major has severe clinical symptoms with craniofacial defects that produce esthetic problems in patients. Orthodontic treatment and surgical reconstruction in these patients have had good esthetic results and therefore satisfying pschycosocial effects. Researches have shown an increase in the level of life quality corresponding to health improvement in thalassemic patients. More knowledge and information is necessary for better treatment of skeletal problems in thalassemia. Subjects and Methods: This descriptive and analytic study was performed on 48-beta thalassemia major patient and 48 normal samples. They were divided into two groups (24 persons based on their genders. Including criteria for samples were : being more than 15 years old, not being affected by special disorders, not having orthodontic and orthopedic treatment, having Cl I profile, normal facial height, Cl I molar relationship, normal overbite and over jet and the presence of all permanent teeth (except third molar. Cephalometric analysis was used for evaluation of cephalograms. The results were analyzed using descriptive statistical and paired sample T-test (P<0.005. Results: SNA angle did no significant increase, but SNB and ANB angles significantly decreased (P<0.005. The angle between SN-Occlusal plans, Frankfort - y-axis plans and basal plans showed increase, but the angle between Frankfort - facial plans (P<0.005 and the distance between pog-NB plan showed decrease (P<0.005. Conclusion: Beta thalassemia major induces Cl II malocclusion and long face growth pattern due to decrease in mandibular growth and decrease in posterior facial height. ?Please cite this paper as: Khanehmasjedi M, Bassir L Mombeyni M. Skeletal Changes in Patients with Beta - Talassemia Major in Ahvaz. JundishapurSci Med J. 2012;11(3:295-302

  5. Skeletal Changes in Patients with Beta –Thalassemia Major in Ahvaz

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    Mashaalah Khanehmasjedi

    2012-07-01

    Full Text Available Background and Objective: Thalassemia major has severe clinical symptoms with craniofacial defects that produce esthetic problems in patients. Orthodontic treatment and surgical reconstruction in these patients have had good esthetic results and therefore satisfying pschycosocial effects. Researches have shown an increase in the level of life quality corresponding to health improvement in thalassemic patients. More knowledge and information is necessary for better treatment of skeletal problems in thalassemia. Subjects and Methods: This descriptive and analytic study was performed on 48-beta thalassemia major patient and 48 normal samples. They were divided into two groups (24 persons based on their genders. Including criteria for samples were : being more than 15 years old, not being affected by special disorders, not having orthodontic and orthopedic treatment, having Cl I profile, normal facial height, Cl I molar relationship, normal overbite and over jet and the presence of all permanent teeth (except third molar. Cephalometric analysis was used for evaluation of cephalograms. The results were analyzed using descriptive statistical and paired sample T-test (P<0.005. Results: SNA angle did no significant increase, but SNB and ANB angles significantly decreased (P<0.005. The angle between SN-Occlusal plans, Frankfort - y-axis plans and basal plans showed increase, but the angle between Frankfort - facial plans (P<0.005 and the distance between pog-NB plan showed decrease (P<0.005.Conclusion: Beta thalassemia major induces Cl II malocclusion and long face growth pattern due to decrease in mandibular growth and decrease in posterior facial height.

  6. Evaluation of Mental Health and Related Factors among Patients with Beta-thalassemia Major in South East of Iran

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    Morteza Ashrafi; Mohammad Reza Hormozi; Majid Naderi; Abolfazl Emamdadi

    2012-01-01

    Objective: Beta-thalassemia major (?-TM) is a chronic, genetic and hematological disorder. Children and teenagers with chronic physical illnesses exemplified by thalassemia are vulnerable to emotional and behavioral problems. The aim of this study was to evaluate mental health and its related factors among young patients with beta-thalassemia major. Methods: In this cross-sectional observational descriptive-analytic study, we studied 164 patients suffering from Beta-thalassemia major wit...

  7. Serum Folate Levels in Major Beta Thalassemia Patients

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    Samin Alavi

    Full Text Available Objective: Beta major thalassemia is a variant of beta thalassemia syndrome which could be treated with bone marrow transplantation or if not available, regular blood transfusion. In the latter case, supportive therapy is the mainstay of treatment because of low folate intake or absorption. But the main cause of insufficient supportive therapy is the increasing need of bone marrow for ineffective erythropoiesis in the absence of regular blood transfusion. The purpose of regular blood transfusion in ? major thalassemia patients is to maintain the range of hemoglobin level between 9 and 11 gr/dl to stop insufficient erythropoiesis completely. Therefore, by regular blood transfusion, supportive therapy with folic acid would not be needed. The aim of this study is to determine serum folate level in regular transfused ? major thalassemia patients in Mofid Children's Hospital during 2006.Methods: This is a cross sectional descriptive–analytic study performed on 100 ? major thalassemia patients receiving regular blood transfusion and desferal. Post-storage leukodepleted blood is used for transfusion. Patients’ data is achieved from information data sheets. Serum folate level is determined with Electrochemiluminescence method in one of the most reliable laboratory centers. Normal serum folate level was 3-17.5 ng/ml in this laboratory with the sensitivity of 0.6 ng. Data analysis is performed with SPSS analysis software, and with chi squared, T-test and Spearman test.Findings: 56 (56% girls and 44 (44% boys entered this study with a median age of 156 (? 71.2 months and an age range of 14-288 months. Patients’ median hemoglobin level was 9.5 (?0.87 g/dl, with minimum of 7.5 and maximum of 11.9 g/dl. Mean MCV was 84.2 (?4.20 fl, with the range of 73.4 -95.3 fl. Serum folate level was in the range of 1-19 ng/ml and median of 9 (? 4.9 ng/ml. Serum folate was less than 3 ng/ml in 3% of evaluated patients. Hemoglobin level was equal or more than 9 g/dl in 73% of patients.Conclusion: It seems that if major ? thalassemia patients receive regular blood transfusion, their serum folate level would be in normal range and supplementation therapy with folate will not be necessary.

  8. Evaluation of pulmonary function in beta-thalassemia major patients

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    Objective: To describe and quantify the functional change of the lung in patients with beta-thalassemia major (TM) and determine the correlation between pulmonary function test (PFT) results with hemoglobin, ferritin and age changes. Methodology: Pulmonary function tests were performed on 60 transfusion-dependent patients with TM, ranging in age from 10 to 45 years. Percent-predicted values for forced expiratory volume in one second (FEV1), and forced expiratory flows (FEF) 25-75% were significantly reduced, whereas forced expiratory vital capacity (FVC) and FEV1/FVC were closed to normal limits, indicating a restrictive disease. All factors including; FVC, FEV1, and FEV1/FVC, FEF 25-75% were negatively correlated with age and ferritin levels. In contrast, all factors including; FVC, FEV1, and FEV1/FVC, FEF 25-75% were positively correlated with hemoglobin (Hb). We performed linear regression analysis to study the simultaneous influence of the presence of age, ferritin, and Hb on obstructive PFT indexes. Results: Pulmonary function test results were normal in only 32 (53.3%) of 60 patients and the rest 28 cases (46.7%) showed abnormal pulmonary function. FEV1 and FEF 25% - 75% have significant negative correlation with age (r = - 0.64 p(r) = 0.003 and r = - 0.58 p(r) = 0.02 respectively), also have significant positive correlation with Hb (r = 0.31 p(r) = 0.015 and r = 0.33 p(r) = 0.01 respectively), and only FEF 25% - 75% has significant negative correlation with ferritin (r -0.26 p(r) = 0.04). Conclusion: The present study has shown that restrictive disease and reduced lung diffusing capacity are the predominant abnormalities of pulmonary function patients with TM. The low hemoglobin concentration and a fall in the diffusing capacity of the alveola - capillary membrane, together with the dependence of the reduced pulmonary diffusing capacity on age and serum ferritin levels, as well as of the entity of restrictive disease on age, suggests that pulmonary dysfunctions in patients with TM are due mainly to lung fibrosis and/or interstitial edema related to iron overload. (author)

  9. Major Causes of Hospital Admission in Beta Thalassemia Major Patients in Southern Iran

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    Jacob Hoseini

    2011-12-01

    Full Text Available Objective: Beta thalassemia major is a prevalent hereditary disease in Mediterranean region especially Iran. Early blood transfusion is necessary for most of the patients and frequent transfusion can cause various medical problems for the patients. The aim of this study was to find major causes of hospital admission in beta thalassemia major patients to reach the accurate preventive and therapeutic plans for these patients.Methods: Four hundred twenty six patients were admitted to the Nemazee Hospital (the main University referral Hospital Center affiliated to Shiraz University of Medical Sciences in Fars Province, southern Iran during 3 years period (January 2007 to January 2010. A questionnaire was filled containing age, gender, hemoglobin level, frequency of blood transfusions, deferoxamine injection, cause of hospital admission and hospital course.Findings: The mean age of patients was 11.28 years. The mean serum ferritin level was 1820±749 µg/lit. Two hundred fifty five (59.75% patients were male and 171 (40.25% patients were female. The top five most prevalent causes of hospital admission were splenectomy (21.8%, infections (19.9%, congestive heart failure (19.0%, diabetes mellitus (13.4%, and Liver biopsy (11.5%. (P=0.0002.Conclusion: Results of this study revealed that infections and complications due to iron overload are major causes of hospital admission in beta thalassemia major patients.

  10. Major Causes of Hospital Admission in Beta Thalassemia Major Patients in Southern Iran

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    Mehran Karimi

    2011-12-01

    Full Text Available Objective: Beta thalassemia major is a prevalent hereditary disease in Mediterranean region especially Iran. Early blood transfusion is necessary for most of the patients and frequent transfusion can cause various medical problems for the patients. The aim of this study was to find major causes of hospital admission in beta thalassemia major patients to reach the accurate preventive and therapeutic plans for these patients.Methods: Four hundred twenty six patients were admitted to the Nemazee Hospital (the main University referral Hospital Center affiliated to Shiraz University of Medical Sciences in Fars Province, southern Iran during 3 years period (January 2007 to January 2010. A questionnaire was filled containing age, gender, hemoglobin level, frequency of blood transfusions, deferoxamine injection, cause of hospital admission and hospital course.Findings: The mean age of patients was 11.28 years. The mean serum ferritin level was 1820±749 ?g/lit. Two hundred fifty five (59.75% patients were male and 171 (40.25% patients were female. The top five most prevalent causes of hospital admission were splenectomy (21.8%, infections (19.9%, congestive heart failure (19.0%, diabetes mellitus (13.4%, and Liver biopsy (11.5%. (P=0.0002Conclusion: Results of this study revealed that infections and complications due to iron overload are major causes of hospital admission in beta thalassemia major patients.

  11. Quality of life among children with beta-thalassemia major treated in Western Saudi Arabia

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    Mohammed D. Ayoub; Radi, Suhaib A.; Abdulrahman M. Azab; Abdulrahman A. Abulaban; Abdulrahman H. Balkhoyor; Seif-eleslam W. Bedair; Soad K. Ajlaouni; Kari, Jameela A

    2013-01-01

    Objectives: To assess the quality of life among children and adolescents with thalassemia major. Methods: This cross-sectional study used the Pediatric Quality of Life Inventory (PedsQL). Children and adolescents with beta-thalassemia major who attended the Day Care Unit at King Abdulaziz University Hospital, Jeddah, Saudi Arabia from October 2012 to February 2013 were surveyed. The questions highlighted 4 health status scales, namely physical functioning (PF), emotional functioning (EF), sch...

  12. Side effects of Deferasirox Iron Chelation in Patients with Beta Thalassemia Major or Intermedia

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    Murtadha Al-Khabori; Sunil Bhandari; Mohammed Al-Huneini; Khalil Al-Farsi; Vinodh Panjwani; Shahina Daar

    2013-01-01

    Objectives: Chelating agents remain the mainstay in reducing the iron burden and extending patient survival in homozygous beta-thalassemia but adverse and toxic effects may increase with the institution and long term use of this essential therapy. This study aimed to estimate the incidence of deferasirox (DFX) side effects in patients with thalassemia major or intermedia.Methods: A retrospective study of 72 patients (mean age: 20.3±0.9 yrs; 36 male, 36 female) with thalassemia major or interm...

  13. [Beta thalassemia major and pregnancy during adolescence: report of two cases].

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    Trigo, Lucas Augusto Monteiro Castro; Surita, Fernanda Garanhani; Parpinelli, Mary Angela; Pereira, Belmiro Gonçalves; Fertrin, Kleber Yotsumoto; Costa, Maria Laura

    2015-06-01

    Beta thalassemia major is a rare hereditary blood disease in which impaired synthesis of beta globin chains causes severe anemia. Medical treatment consists of chronic blood transfusions and iron chelation. We describe two cases of adolescents with beta thalassemia major with unplanned pregnancies and late onset of prenatal care. One had worsening of anemia with increased transfusional requirement, fetal growth restriction, and placental senescence. The other was also diagnosed with hypothyroidism and low maternal weight, and was admitted twice during pregnancy due to dengue shock syndrome and influenza H1N1-associated respiratory infection. She also developed fetal growth restriction and underwent vaginal delivery at term complicated by uterine hypotonia. Both patients required blood transfusions after birth and chose medroxyprogesterone as a contraceptive method afterwards. This report highlights the importance of medical advice on contraceptive methods for these women and the role of a specialized prenatal follow-up in association with a hematologist. PMID:26200828

  14. Anxiety, depression and quality of life in patients with beta thalassemia major and their caregivers

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    Yengil, Erhan; Acipayam, Can; Kokacya, Mehmet Hanifi; Kurhan, Faruk; Oktay, Gonul; Ozer, Cahit

    2014-01-01

    Mental health and health related quality of life is commonly affected in patients with chronic problems and their caregivers. In the present study, it was aimed to assess depression and anxiety in patients with beta thalassemia major (BTM) and in their caregivers; and to evaluate effects of these disorders on quality of life. The study was carried out in a district Hereditary Hemoglobinopathy Center and included 88 patients with BTM and 63 of their caregivers. All subjects were assessed using...

  15. Hypoparathyroidism and Intracerebral Calcifications in Patients with Beta-Thalassemia Major

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    A. Nabavizadeh; M. Karimi; A. Rasekhi; Rasekh, M; R. Assadsangabi; Gh. Amirhakimi

    2008-01-01

    Background/Objective: Hypoparathyroidism is one of the most important endocrine complications of thalassemia major. This study was conducted to evaluate the prevalence of intracerebral calcifications in patients with thalassemia with and without hypoparathyroidism."nPatients and Methods: Forty-seven beta-thalassemia patients with hypoparathyroidism underwent a brain CT scan to investigate the presence and extent of intracerebral calcifications. Thirty age and sex-matched beta-thalassemic...

  16. A cross-sectional study of metabolic and endocrine complications in beta-thalassemia major

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    Iron overload is a major problem in patients with beta-thalassemia major, and it has many structural and metabolic consequences. The aim of this study was evaluation of endocrine disturbances in patients with beta-thalassemia major who were older than 10 years of age. In this cross-sectional study, investigator collected demographic data and medical histories, as well as menstrual history in females, from the medical records of 56 patients with beta-thalassemia major. Patients were examined to determine their pubertal status and the standard deviation score for height for evaluation of short stature. For evaluation of glucose tolerance, a fasting blood glucose and oral glucose tolerance tests were performed. Evidence for diabetes mellitus was based on American Diabetes Association and World Health Organization criteria. Serum levels of calcium, phosphorous, thyroid-stimulating hormone, free thyroxin, luteinizing hormone and follicular-stimulating hormone and estradiol in girls and testosterone in boys were measured. The mean and standard deviation for age in the 56 patients (36 males and 20 females) was 15.62+-4.44 years. Diabetes mellitus was present in 5 patients (8.9%), impaired fasting glucose was found in 16 patients (28.6%) and an impaired glucose tolerance test was found in 4 patients (7.1%). Short stature (standard deviation score <-2) was seen in 25 (70%) boys and 14 (73%) girls. Impaired puberty was found in 40 patients (71%). Hypocalcaemia and primary overt hyperthyroidism were present in 23 (41%) and 9 patients (16%), respectively. Only eight patients (14.3%) had no endocrine abnormalities. Despite therapy with deferoxamine to treat iron overload, the risk of secondary endocrine dysfunction remained high. Hypogonadism was one of the most frequent endocrine complications. Impaired glucose tolerance, short stature, hypocalcemia, subclinical and overt hypothyroidism are also frequent. (author)

  17. A cross-sectional study of metabolic and endocrine complications in beta-thalassemia major

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    Najafipour Farzad

    2008-01-01

    Full Text Available Background and Objectives: Iron overload is a major problem in patients with beta-thalassemia major, and it has many structural and metabolic consequences. The aim of this study was evaluation of endocrine disturbances in patients with beta-thalassemia major who were older than 10 years of age. Patients and Methods: In this cross-sectional study, investigators collected demographic data and medical histories, as well as menstrual history in females, from the medical records of 56 patients with beta-thalassemia major. Patients were examined to determine their pubertal status and the standard deviation score for height for evaluation of short stature. For evaluation of glucose tolerance, a fasting blood glucose and oral glucose tolerance test were performed. Evidence for diabetes mellitus was based on American Diabetes Association and World Health Organization criteria. Serum levels of calcium, phosphorous, thyroid-stimulating hormone, free thyroxin, luteinizing hormone and follicular-stimulating hormone, and estradiol in girls and testosterone in boys were measured. Results: The mean and standard deviation for age in the 56 patients (36 males and 20 females was 15.62±4.44 years. Diabetes mellitus was present in 5 patients (8.9%, impaired fasting glucose was found in 16 patients (28.6% and an impaired glucose tolerance test was found in 4 patients (7.1%. Short stature (standard deviation score Conclusion: Despite therapy with deferoxamine to treat iron overload, the risk of secondary endocrine dysfunction remained high. Hypogonadism was one of the most frequent endocrine complications. Impaired glucose tolerance, short stature, hypocalcemia, subclinical and overt hypothyroidism are also frequent.

  18. Ambulatory Blood Pressure Monitoring for Children With Beta–Thalassemia Major: a Preliminary Report

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    Morteza Tabatabaie

    2013-07-01

    Full Text Available Introduction. Heart disease is one of the most common reasons of death in beta-thalassemia major. A few studies have been done in children about blood pressure changes. The aim of this study was to assess hemodynamic changes by ambulatory blood pressure monitoring (ABPM. Materials and Methods. In this cross-sectional study, 30 patients with beta-thalassemia major aged 5 to 18 years old were evaluated with 24-hour ABPM. The exclusion criteria were an ejection Fraction less than 50% and a glomerular filtration rate less than 90 mL/min/1.73 m2. Hypertension was defined as a mean blood pressure index of 1 and greater with or without load blood pressure greater than 25%. Dipper status was defined as a 10% decrease in nighttime versus daytime mean arterial blood pressure. Results. High blood pressure was detected in 16.7% of the patients. The whole-day ABPM showed hypertension in 6.7% of the children. During daytime measurements, systolic hypertension was seen in 3.3% (load 3.7% and diastolic in 6.7% (load 3.3%. These figures for nighttime evaluation were 6.7% (load 3.3% and 10.3% (load 6.9%, respectively. Nondipper status was detected in 56.7% of the children. There was no significant correlation between abnormal blood pressure and age, sex, body mass index, hemoglobin, number or rates of blood transfusion, or serum ferritin level. Conclusions. The ABPM may be a useful instrument for early detection of hemodynamic changes in children with beta-thalassemia major.

  19. Zinc and Copper Status in Children with Beta-Thalassemia Major

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    Abolfazl Mahyar

    2010-09-01

    Full Text Available Objective:There are some reports in which a condition of zinc deficiency and its associated outcomes with a change in concentration of serum copper among the thalassemic patients has been highlighted. The aim of this prospective study was to determine the serum zinc and copper levels in children with beta-thalassemia major.Methods:In this cross sectional study all children under 12 years affected by beta thalassemia major (40 patients were evaluated for serum zinc and copper levels in Qazvin thalassemia center (Qazvin, Iran in 2007. Serum measurements for zinc and copper were performed by atomic absorption spectrophotometer.Findings:The mean concentrations of serum zinc and copper levels were 67.35?20.38 and 152.42?24.17 ?g/dl respectively. Twenty-six (65% of thalassemic patients had zinc concentration under 70 ?g/dl (hypozincemia. None of the thalassemic children had copper deficiency. No significant correlation between serum zinc level with age, weight, height, body mass index, duration of blood transfusion, desferrioxamine dose and ferritin level was observed in thalassemic patients (P=0.3.Conclusion:This study revealed that hypozincemia is common in thalassemic patients, but in contrast, there is no copper deficiency. Further evaluation in this regard is recommended.

  20. Assessment Hepatomegaly and liver Enzymes in 100 Patients with beta Thalassemia Major in Mashhad, Iran

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    kolagari SH

    2012-12-01

    Full Text Available AbstractBackgroundFrequent blood transfusion in patients with beta thalassemia major can lead to iron overloadespecially in liver. Chronic iron overload could cause cirrhosis of the liver. Transfusiontransmittedhepatitis B and C also could develop cirrhosis in individuals.Materials and MethodsThe present cross- sectional descriptive study is to assess hepatomegaly and liver enzymes in 100patients with beta thalassemia major, ages between 2-18 years old. The study was carried outretrospectively. One hundred medical records have chosen from 400 samples of thalassemiamajor patients, who are under a regular care of the department of sarvar clinic.ResultsOut of these patients, 55% were male and 45% female. The mean age of thalassemia patients was10.8 4.4 years. The mean and S. D of hemoglobin, ferritin, deferoxamine dosage was 8.5 ±1.5g/dl , 2183 ± 1528 ng , 30 ± 11.16 mg/kg, respectively. Forty six percent of them hadhepatomegaly. The mean and S. D of AST and ALT were 95± 70 IU/L and 70 ±35U/Lrespectively. Splenectomy was performed on 44% of patient.ConclusionHepatomegaly is one of the most common findings in the thalassemic patient that induced withhemosiderosis and hepatitis.

  1. Frequency of hepatitis B and hepatitis C in multi - transfused beta thalassemia major patients

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    To determine the frequency of hepatitis B and C virus infection among children with beta thalassemia major registered at Military Hospital Rawalpindi. Children attending Thalassemia Centre Military Hospital Rawalpindi for regular blood transfusion were registered. They belonged to different ethnic groups and came from different parts of the country. Their demographic data was recorded, detailed history taken and physical examination was carried out. Their serum samples were tested for hepatitis B surface antigen and anti HCV antibody assay with third generation commercial ELISA method. During the study; 141 patients of beta thalassemia major were screened. Out of them 50 patients (35.5% ,95% confidence interval 27.8-43.5)w ere found hepatitis C virus antibody positive and 1 patient (0.7 %) hepatitis B surface antigen positive. One patient (0.7%) had both hepatitis B and C virus infection. Mean age of hepatitis C infected patients was 10.4+3.85y ears (range 2-16 years). Mean age of uninfected patients was 6.1 + 3.59 years. (p value 0.000) In addition, the results indicate that higher prevalence of anti-HCV was significantly associated with longer duration of transfusion (p value <0.003). In spite of the fact that screened blood is used for transfusions, still a large number of patients have been found infected with hepatitis C. Therefore more accurate techniques are required for screening of blood to prevent transfusion associated transmission. (author)

  2. Hypoparathyroidism and intracerebral calcification in patients with beta-thalassemia major

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    Karimi, M. [Iran-Shiraz-Namazee Hospital, Namazee Square, Hematology Research Center, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of)], E-mail: karimim@sums.ac.ir; Rasekhi, A.R. [Iran-Shiraz-Namazee Hospital, Namazee Square, Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of)], E-mail: rasekhia@sums.ac.ir; Rasekh, M. [Iran-Shiraz-Namazee Hospital, Namazee Square, Department of Endocrinology and Metabolism, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of)], E-mail: Rasekhm@sums.ac.ir; Nabavizadeh, S.A. [Iran-Shiraz-Namazee Hospital, Namazee Square, Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of)], E-mail: nabavia@gmail.com; Assadsangabi, R. [Iran-Shiraz-Namazee Hospital, Namazee Square, Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of)], E-mail: assadsangabi@yahoo.com; Amirhakimi, G.H. [Iran-Shiraz-Namazee Hospital, Namazee Square, Department of Endocrinology and Metabolism, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of)], E-mail: amirhakimig@sums.ac.ir

    2009-06-15

    Background: Hypoparathyroidism is one of the most important endocrine complications of thalassemia major. This study was conducted to evaluate the prevalence of intracerebral calcifications in patients with thalassemia with and without hypoparathyroidism. Methods: 47 beta-thalassemia patients with hypoparathyroidism underwent a brain CT scan to investigate the presence and extent of intracerebral calcification. 30 age- and sex-matched beta-thalassemic patients with normal parathyroid function who had undergone brain CT for headache, or some other minor neurologic problems were also enrolled in the study serving as controls. The amount of intracerebral calcification, hematologic parameters, and some clinical findings were compared between both groups. Results: Intracerebral calcification was present in 54.2% of beta-thalassemia patients with hypoparathyroidism. The most frequent sites of calcification were basal ganglia, and frontoparietal areas of the brain. Thalami, internal capsule, cerebellum and posterior fossa were other less frequently calcified regions of the brain. In contrast, there was no evidence of intracerebral calcifications in the 30 thalassemic patients with normal parathyroid function. There was not a statistically significant difference between serum ferritin concentrations in thalassemia patient with hypoparathyroidism and those with normal parathyroid function (2781 vs. 2178, P > 0.05). Conclusion: Intracranial calcification is a common finding in thalassemia patients with hypoparathyroidism, it can be extensive and involves most regions of the brain.

  3. Hypoparathyroidism and intracerebral calcification in patients with beta-thalassemia major

    International Nuclear Information System (INIS)

    Background: Hypoparathyroidism is one of the most important endocrine complications of thalassemia major. This study was conducted to evaluate the prevalence of intracerebral calcifications in patients with thalassemia with and without hypoparathyroidism. Methods: 47 beta-thalassemia patients with hypoparathyroidism underwent a brain CT scan to investigate the presence and extent of intracerebral calcification. 30 age- and sex-matched beta-thalassemic patients with normal parathyroid function who had undergone brain CT for headache, or some other minor neurologic problems were also enrolled in the study serving as controls. The amount of intracerebral calcification, hematologic parameters, and some clinical findings were compared between both groups. Results: Intracerebral calcification was present in 54.2% of beta-thalassemia patients with hypoparathyroidism. The most frequent sites of calcification were basal ganglia, and frontoparietal areas of the brain. Thalami, internal capsule, cerebellum and posterior fossa were other less frequently calcified regions of the brain. In contrast, there was no evidence of intracerebral calcifications in the 30 thalassemic patients with normal parathyroid function. There was not a statistically significant difference between serum ferritin concentrations in thalassemia patient with hypoparathyroidism and those with normal parathyroid function (2781 vs. 2178, P > 0.05). Conclusion: Intracranial calcification is a common finding in thalassemia patients with hypoparathyroidism, it can be extensive and involves most regions of the brain.

  4. Anaesthetic management of beta thalassemia major with hypersplenism for splenectomy in pediatric age group: Report of four cases.

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    Jyothi, B; Sushma, K S; Syeda, Seham; Raza, Syed Owais

    2015-01-01

    Beta thalassemia is the most common cause of hemolytic anemia in India. Hereby we are reporting four cases of beta thalassemia major aged between 5 and 10 years posted for splenectomy over a period of 2 months. These patients were on repeated blood transfusions since the day of diagnosis, and two patients had a history of cardiac failure. In addition to emphasizing the anesthetic challenges, the purpose of reporting such cases is to raise the awareness of the disease and prevention of the same by aggressive screening and prenatal diagnosis. PMID:26417142

  5. Beta Thalassemia

    Science.gov (United States)

    ... iron overload which must be treated with chelation therapy to prevent early death from organ failure. In a somewhat milder form, the inheritance of two abnormal beta globin genes may cause beta thalassemia intermedia , in which the lack of beta globin ...

  6. Bone metabolism and mineral density in patients with beta-thalassemia major

    International Nuclear Information System (INIS)

    To evaluate bone metabolism in patients with beta-thalassemia major and to determine the factors associated with the development of osteoporosis. We studied 25 patients with thalassemia major with a mean age of 18.4 years (rang 5-31), age and gender matched 24 healthy controls who were attending the outpatient physical medicine and rehabilitation clinic of Akdeniz University Hospital between January 2004 and March 2004 in Turkey. Bone mineral density (BMD) of lumbar spine (L-1-L4) and proximal femur were determined using dual x-ray absorptiometry (DXA). Venous blood samples were obtained for determination of blood cell count and markers of bone formation and resorption. The BMD values, both at lumbar and femoral neck levels were significantly lower in patients compared to controls. Serum N-telopeptide level was slightly higher, whereas osteocalcin was slightly lower in patients, however, the values were not statistically significant. Plasma levels of insulin like growth factor-1 (IGF-I) and insulin like growth factor for binding protein-3 (IGFBP-3) were significantly lower in patients. Also, serum levels of estradiol and progesterone in females, luteinizing, hormone and follicle-stimulating hormone in both genders were significantly lower in patients. Serum levels of free testosterone and total testosterone were lower in patients, but not statistically significant. Patients also had significantly higher serum phosphorous levels and lower serum calcitonin levels compared to controls. The BMD is decreased in thalassemic patients. Growth retardation, growth hormone/IGF-I/IGFP-3 axis dysfunction, gonadal dysfunction and hypothalomo-pituitary-gonadal axis dysfunction may be responsible for the development of osteoporosis in the patients with beta-thalassemia major. (author)

  7. Peripheral Blood Stem Cell Transplantation in Patients with Beta-Thalassemia Major

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    Ghavamzadeh A

    2004-08-01

    Full Text Available From 1996 to 2002, fifty three patients with major beta-thalassemia received allogeneic peripheral blood stem cell trans¬plantation (PBSCT. Median age was 6 years .Twenty two were class I, 17 class II and 14 class III. All of the donors were HLA-identical. Conditioning regimen for class I and II patients consisted of Cyclophosphamide (CY 50 mg/kg/day for 4 days + Busulfan (Bu 3.5 mg/kg for 4 days, while class III patients received 4 mg/kg/day Busulfan for 4 days and 40mg/kg/day Cyclophosphomide for 4 days. G-CSF (Neopogen 5µ/kg IV was given to donors. Graft Versus Host Disease (GVHD prophylaxis regimen consisted of Cyclosporin-A (CsA 3 mg/kg/day plus Methotrexate (MTX 10 mg/m2 on day+1 and 6 mg/m2 on days +3 and +6. The median time for neutrophil and platelet engraftment was day +16 and day +23 post transplantation, respectively. Chronic GVHD (cGVHD was observed in 30 patients (56%. Ten patients (18.8% died. Forty patients are well and transfusion independent. Median time of follow-up was 23 months. Recurrences have been seen at 3 pts, one patient 21 months, the other one 6 months and the last one 8 months after transplantation, who received Donor Lymphocyte infusion (DLI. Event free survival was 72% and overall survival was 80%. In conclusion, we suggest that PBSCT can be considered a safe and effective treatment for children with Beta-thalassemia major and cGVHD is tolerable and manageable in these patients.

  8. Prospects and future of conservative management of beta thalassemia major in a developing country

    International Nuclear Information System (INIS)

    Objective: To assess the efficacy, prospects and future of conservative management of beta thalassemia major patients in a developing country. Design: Patients registered at IHBTS were studied over a period of three years. They consented to being managed on moderate transfusion regimen, aiming to maintain a pre-transfusion haemoglobin(Hgb) level of 9.0 plus minus 1.0 g per dL. We studied their transfusion requirements, status for transfusion transmitted infections (TTls), serum ferritin levels and complications developing as a result of iron overload. Subjects: Initially all registered patients were included in this study. Sporadic patients as well as dropouts occurring due to any reason, (patients concurrently seeking treatment at other centres as well, or complying poorly to advised chelation therapy) were excluded from the study. The data presented here conforms to a cohort of 60 regular patients who adhered best to our selection criteria. Main Outcome Measures: 1) The study highlights the deficiencies and problems of conservative management for beta thalassemia major. 2) The major impact of our study is the message that conservative management in a poor country, like ours, is a no-win situation. 3) There is an urgent need to immediately start a prevention programme. Results: In the younger patients, blood consumption even on the moderate transfusion regimen is 120ml/kg/year, however with ascending age the consumption increases to 240ml/kg/year. A substantive number of the patients are either Hep C (35%) or Hep B (1.7%) positive. There are no HIV positive patients. Serum ferritin levels vary widely and could not be controlled due to poor compliance to chelation. 50% of the patients developed one or other complications of iron overload. The cost of treatment depending on the quality of care, is tremendous and beyond the reach of the common man. Conclusions: Conservative management may be the best alternative and at times the only hope for patients in our country. However, in order to decrease the disease load, steps need to be taken to introduce preventive measures. (author)

  9. Psychological Aspects in Young Adults with Beta-Thalassemia Major, control group

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    S. H. Hosseini, M.D.

    2007-09-01

    Full Text Available Background and purpose: Beta-thalassemia major (TM, a chronic, genetically determined hematological disorder, has received little investigation on the psychological aspects of the disease and the psychosocial adjustment of patients with this anemia. In the present study, the aim was to explore the nature of psychopathology according to age, sex, school performance, severity and complications of the disease in TM patients compared with demographically matched healthy persons.Materials and Methods: A controlled anterograde cohort study was conducted at the Thalassemia Unit of Boo-Ali Hospital from June 2003 to November 2005 in Sari, Iran. Psychological aspects were evaluated by the Persian version of symptoms checklist-90-revised questionnaire. Information on relevant demographic characteristics, school performance, severity and complications of the disease was collected by one of the investigators who had created the questionnaire.Results: 125 persons with TM completed the questionnaires and were compared with 125 controls and 250 totally. The mean age of the participants was 18.51± 2.0 years and with a range of 15-25 years. 132 (52.8% were female with equal family status, social and economic status. Patients group reported a significantly lower level of marital status (P<0.01, education level (P<0.0001, school performance (P<0.0001. TM patients were found to have significantly more psychiatric disorders than the control subjects with GSI: 1.16 ± 0.47 vs. 1.01 ± 0.6; (P<0.03, PSD: 54.99 ± 12.59 vs. 46.42 ± 18.76 (P<0.0001, and PSDI 2.02±1.02 vs 2.45 ± 2.22 (P<0.05. We recorded significant changes in the mean scores of somatization (P<0.0001, interpersonal sensitivity (P<0.0001, depression (P<0.003, anxiety (P<0.05 and psychoticism (P<0.03 in the TM patients as compared to the control subjects.Conclusion: These findings show that beta-thalassemia major patients are at risk for psychiatric symptomatology and need appropriate psychiatric consultation.

  10. Frequency of Sensory Neural Hearing Loss in Major Beta-Thalassemias in Southern Iran

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    Seyed-Taghi Heydari

    2010-09-01

    Full Text Available Objective:The thalassemias are among the most common genetic disorders worldwide, occurring more frequently in the Mediterranean region. The aim of this study was to determined frequency of sensory-neural hearing loss in major ß- thalassemias transfusion dependent patients in south of Iran. Methods:A cross sectional study on 308 cases of major beta-thalassemia patients referring to Thalassemia Center of Shiraz University of Medical Sciences between 2006-2007 years. The diagnosis of ß- thalassemia major was based on clinical history, complete blood count and hemoglobine electrophoresis. Clinical data such as serum ferritin level, deferoxamine (DFO dose, mean daily doses of DFO (mg/kg and audiometric variables was recorded. Findings:Out of 308 cases, 283 (96.5% had normal hearing and 10 (3.5% sensorineural hearing loss. There was no statically significant difference between two groups regarding mean age, weight, age at the first blood transfusion, age at the first DFO infusion. Conclusion:We found the lowest incidence of sensorineural hearing loss in a large population of patients suffered from major thalassemia who received DFO. We show that DFO is not ototoxic at a low dose. When considering all related literature, as a whole there has been much critical misrepresentation about DFO ototoxicity.

  11. Frequency of Sensory Neural Hearing Loss in Major Beta-Thalassemias in Southern Iran

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    Abolhassan Faramarzi

    2010-09-01

    Full Text Available Objective:The thalassemias are among the most common genetic disorders worldwide, occurring more frequently in the Mediterranean region. The aim of this study was to determined frequency of sensory-neural hearing loss in major ß- thalassemias transfusion dependent patients in south of Iran.Methods:A cross sectional study on 308 cases of major beta-thalassemia patients referring to Thalassemia Center of Shiraz University of Medical Sciences between 2006-2007 years. The diagnosis of ß- thalassemia major was based on clinical history, complete blood count and hemoglobine electrophoresis. Clinical data such as serum ferritin level, deferoxamine (DFO dose, mean daily doses of DFO (mg/kg and audiometric variables was recorded.Findings:Out of 308 cases, 283 (96.5% had normal hearing and 10 (3.5% sensorineural hearing loss. There was no statically significant difference between two groups regarding mean age, weight, age at the first blood transfusion, age at the first DFO infusion.Conclusion:We found the lowest incidence of sensorineural hearing loss in a large population of patients suffered from major thalassemia who received DFO. We show that DFO is not ototoxic at a low dose. When considering all related literature, as a whole there has been much critical misrepresentation about DFO ototoxicity.

  12. Evaluation of Mental Health and Related Factors Among Patients with Beta-Thalassemia Major in South East of Iran

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    Morteza Ashrafi

    2012-04-01

    Full Text Available Objective: Beta-thalassemia major (?-TM is a chronic, genetic and hematological disorder. Children and teenagers with chronic physical illnesses exemplified by thalassemia are vulnerable to emotional and behavioral problems. The aim of this study was to evaluate mental health and its related factors among young patients with beta-thalassemia major. Methods: In this cross-sectional observational descriptive-analytic study, we studied 164 patients suffering from Beta-thalassemia major with age range of 15-24 years who referred for treatment to Ali Ebn-e Abitaleb (AS University Hospital in Zahedan, a city in South East of Iran, during 2009- 2010. The demographic data and pattern of mental health were collected by standard general health questionnaire (GHQ-28.Data was analyzed using statistical software SPSS (version 17.0; Student t test and Chi-square (?2 were used. Results: In this study, 96 (58.5% patients were male; the mean age of all patients was 18.78 ±2.28. Based on data analysis, 83 patients (50.8% suspected to have psychiatric disorders (58.8% of girls, 44.8% of boys. In addition, frequency of somatic symptoms, depression disorder, anxiety disorder and social dysfunction in all patients were 7.3%, 11.6%, 8.5% and 4.3% respectively. In illiterate patients, 70.4% suspected to have psychiatric disorder. Except for somatic disorder, other mental disorders were more frequent in girls. No significant association was found between mental state and gender, marital and literacy status and occupation. Conclusion : In this study, due to high prevalence of psychological disorders in young patients with Beta-thalassemia major, especially in girls, we suggest implementing further educational psychological programs to decrease the frequency of disorders. Moreover, conducting more quantitative and comprehensive researches is suggested to evaluate specific effective factors in psycho-social health.

  13. The pancreas in {beta}-thalassemia major: MR imaging features and correlation with iron stores and glucose disturbunces

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    Papakonstantinou, Olympia [University Hospital of Heraklion, Medical School of Crete, Department of Radiology, Heraklion, Crete (Greece); Attikon Hospital, 2nd Department of Radiology, Athens (Greece); Ladis, Vasilios; Kostaridou, Stavroula; Berdousi, Helen; Kattamis, Christos [Thalassemia Unit, University of Athens, ' ' Aghia Sophia' ' Children' s Hospital, Athens (Greece); Maris, Thomas; Gourtsoyiannis, Nicholas [University Hospital of Heraklion, Medical School of Crete, Department of Radiology, Heraklion, Crete (Greece)

    2007-06-15

    The study aims at describing the MR features of pancreas in beta-thalassemia major, investigating the relations between MR findings and glucose disturbances and between hepatic and pancreatic siderosis. Signal intensity ratios of the pancreas and liver to right paraspinous muscle (P/M, L/M) were retrospectively assessed on abdominal MR imaging studies of 31 transfusion-dependent patients with beta-thalassemia major undergoing quantification of hepatic siderosis and 10 healthy controls, using T1- (120/4/90), intermediate in and out of phase - (120/2.7, 4/20), and T2*-(120/15/20) weighted GRE sequences. Using the signal drop of the liver and pancreas on opposed phase images, we recorded serum ferritin and results of oral glucose tolerance test (OGTT). Decreased L/M and P/M on at least the T2* sequence were noticed in 31/31 and 30/31 patients, respectively, but no correlation between P/M and L/M was found. Patients with pathologic OGTT displayed a higher degree of hepatic siderosis (p < 0.04) and signal drop of pancreas on opposed phase imaging (p < 0.025), implying fatty replacement of pancreas. P/M was neither correlated with glucose disturbances nor serum ferritin. Iron deposition in the pancreas cannot be predicted by the degree of hepatic siderosis in beta-thalassemia major. Fatty replacement of the pancreas is common and may be associated with glucose disturbances. (orig.)

  14. The survival analysis of beta thalassemia major patients in South East of Iran

    International Nuclear Information System (INIS)

    The objective was to determine the survival of beta-thalassemia major patients with transfusion, and its related factors in Southeast of Iran. This cross-sectional study was performed in Zahedan, Iran in 2007. The sample included patients who were referred from all over the Zahedan Thalassemia Center from 1998 to 2006. The data were collected using the patient's records, which were recorded by the staff during transfusion. The data included demographic and medical information blood group, blood RH, the kind of transfused blood [KTB], annual number of transfusions [ANOT], accompanied disease [AD], Hemoglobin [Hb] and ferritin level. For data analysis, the Kaplan-Meyer method, and Long Rank test together with Cox Regression were used. Forty-six of 578 patients died and 99% survived for the first year. The ages survival proportions were 5 (97.9%), 10 (97%), 15 (92.1%), and 20 (81.2%) years. The survival time showed significant relationships with the ANOT p=0.0053, KTB p=0.003, Hb=0.002 and ferritin level p=0.0087, and AD p=0.00. Using regular transfusion, paying attention to screening of transfused blood, increasing the families knowledge on the disease to prevent the bearing of thalassemia fetus, are recommended; finally, the detection and treating of the AD, are of great importance to extend the lifetime of the patients. (author)

  15. Hypoparathyroidism and Intracerebral Calcifications in Patients with Beta-Thalassemia Major

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    A. Nabavizadeh

    2008-01-01

    Full Text Available Background/Objective: Hypoparathyroidism is one of the most important endocrine complications of thalassemia major. This study was conducted to evaluate the prevalence of intracerebral calcifications in patients with thalassemia with and without hypoparathyroidism."nPatients and Methods: Forty-seven beta-thalassemia patients with hypoparathyroidism underwent a brain CT scan to investigate the presence and extent of intracerebral calcifications. Thirty age and sex-matched beta-thalassemic patients with normal parathyroid function who had undergone brain CT for headache, or some other minor neurologic problems were also enrolled in the study as control group. The amount of intracerebral calcifications, hematologic parameters, and some clinical findings were com-pared between both groups."nResults: Intracerebral calcification was present in 54.2% of beta -thalassemai patients with hypoparathyroidism. The most frequent sites of calcification were basal ganglia, and frontoparietal areas of the brain. Thalami, internal capsule, cerebellum and posterior fossa were other less frequently calcified regions of the brain. Conversely intracerebral calcification was not seen in the 30 thalassemia patients with normal parathyroid function. There was not a statistically significant difference between serum ferritin concentrations in thalassemia patients with hy-poparathyroidism and those with normal parathyroid function (2781 vs. 2178, P>0.05."nConclusion: Intracranial calcification is a common finding in thalassemia patients with "nhypoparathyroidism. It can be extensive and involves most regions of the brain.

  16. Health Related Quality of Life, Depression, Anxiety and Stress in Patients with Beta-Thalassemia Major

    Science.gov (United States)

    Adib-Hajbaghery, M; Ahmadi, M; S, Poormansouri

    2015-01-01

    Background Awareness of factors associated with quality of life (QOL) in patients with beta-Thalassemia major (β-TM) is necessary to develop clinical programs in order to improve social support and QOL in β-TM patients. This study aimed to examine QoL, depression, anxiety, and stress in β-TM patients in Ahvaz, Iran. Materials and Methods A cross-sectional study was conducted on173 β-TM patients aged ≥12 years (12-18=55, ≥19=118). Subjects were selected using a census method. Data collection instrument consisted of three parts including: demographic questions, SF-36 questionnaire and depression, anxiety, and stress scale (DAS-21). Results The participants obtained a mean score of 64.38±18.20 for QOL, 6.4±5.1 for depression, 4.8±3.9 for anxiety, and 7.3±4.9 for stress. Significant relationship was found between QOL and employment (P=0.02) and education level (P<0.001). Patients in the age group of 12-18 years old had higher mean scores in the majority of QoL dimensions than those aged ≤19. The mean scores of depression, anxiety, and stress were higher in patients aged ≤19. No significant correlation was observed between QOL and depression, anxiety, stress scores, and other demographic variables. Moreover, a significant inverse correlation was found between QOL and depression (P<0.001,r= -0.62), anxiety (P<0.001,r= -0.55), and stress scores (P<0.001, r= -0.5) . Conclusion This study showed that β-TM patients experienced a considerable decrease both in their overall QoL and in its dimensions. A majority of the β-TM patients were also suffered from mild to severe depression, anxiety, and stress.

  17. Side effects of Deferasirox Iron Chelation in Patients with Beta Thalassemia Major or Intermedia

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    Murtadha Al-Khabori

    2013-03-01

    Full Text Available Objectives: Chelating agents remain the mainstay in reducing the iron burden and extending patient survival in homozygous beta-thalassemia but adverse and toxic effects may increase with the institution and long term use of this essential therapy. This study aimed to estimate the incidence of deferasirox (DFX side effects in patients with thalassemia major or intermedia.Methods: A retrospective study of 72 patients (mean age: 20.3±0.9 yrs; 36 male, 36 female with thalassemia major or intermedia treated at Sultan Qaboos University Hospital, Oman, was performed to assess the incidence of side effects related to deferasirox over a mean of 16.7 month follow-up period.Results: Six patients experienced rashes and 6 had gastro-intestinal upset. DFX was discontinued in 18 patients for the following reasons: persistent progressive rise(s in serum creatinine (7 patients; 40% mean serum creatinine rise from baseline, feeling unwell (2, severe diarrhea (1, pregnancy (1, death unrelated to chelator (2 and rise in serum transaminases (2. Three patients were reverted to desferoxamine and deferiprone combination therapy as DFX was no longer biochemically effective after 18 months of therapy. There was no correlation between baseline serum ferritin and serum creatinine or a rise in serum creatinine. Cardiac MRI T2* did not change with DFX therapy. However, there was an improvement in liver MRI T2* (p=0.013.Conclusion: Renal side effects related to deferasirox appear to be higher than those reported in published clinical trials. Further larger studies are required to confirm these findings.

  18. Survival Analysis and its Associated Factors of Beta Thalassemia Major in Hamadan Province

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    Reza Zamani

    2015-05-01

    Full Text Available Background: There currently is a lack of knowledge about the long-term survival of patients with beta thalassemia (BT, particularly in regions with low incidence of the disease. The aim of the present study was to determine the survival rate of the patients with BT major and the factors associated with the survival time. Methods: This retrospective cohort study was performed in Hamadan province, located in the west of Iran. The study included patients that referred to the provincial hospitals during 16 year period from 1997 to 2013. The follow up of each subject was calculated from the date of birth to the date of death. Demographic and clinical data were extracted from patients’ medical records using a checklist. Statistical analysis included the Kaplan-Meier method to analyze survivals, log-rank to compare curves between groups, and Cox regression for multivariate prognostic analysis. Results: A total of 133 patients with BT major were enrolled, 54.9% of whom were male and 66.2% were urban. The 10-, 20- and 30-year survival rate for all patients were 98.3%, 88.4% and 80.5%, respectively. Based on hazard ratio (HR, we found that accompanied diseases (P=0.01, blood type (P=0.03 and residency status (P=0.01 were significant predictors for the survival time of patients. Conclusion: The survival rate of BT patients has improved. Future researches such as prospective designs are required for the estimation of survival rate and to find other prognostic factors, which have reliable sources of data.

  19. Anxiety, depression and quality of life in patients with beta thalassemia major and their caregivers.

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    Yengil, Erhan; Acipayam, Can; Kokacya, Mehmet Hanifi; Kurhan, Faruk; Oktay, Gonul; Ozer, Cahit

    2014-01-01

    Mental health and health related quality of life is commonly affected in patients with chronic problems and their caregivers. In the present study, it was aimed to assess depression and anxiety in patients with beta thalassemia major (BTM) and in their caregivers; and to evaluate effects of these disorders on quality of life. The study was carried out in a district Hereditary Hemoglobinopathy Center and included 88 patients with BTM and 63 of their caregivers. All subjects were assessed using Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Short Form-36 (SF-36) by a trained psychiatry resident via face-to-face interview. The BDI scores were 17 or above in 20.5% of the patients with BTM and 28.6% of their caregivers (P = 0.248). Of the patients with BTM, there were mild anxiety symptoms in 19.3%, while moderate and severe anxiety symptoms in 14.8% and 4.5%, respectively. Anxiety levels were similar between the patients with BTM and their caregivers (P = 0.878). It was found that BDI and BAI scores were negatively correlated to scores of physical health and mental health components of SF-36 in patients with BTM and their caregivers. In linear regression analysis, it was seen that depression affected physical and mental health of the patients with BTM and their caregivers regardless from anxiety. BTM leads an increase in the frequency of depression and anxiety in both patients and their caregivers, and affects negatively physical and mental components of quality of life. PMID:25232402

  20. Plasma Zinc Level in Hepatitis C Patients With or Without Beta Thalassemia Major; Is There Any Difference?

    Science.gov (United States)

    Abbasinazari, Mohammad; Behnava, Bita; Panahi, Yunes; Hajhossein Talasaz, Azita; Salimi, Shima; Keshvari, Maryam; Mehrnoush, Leila; Karimi Elizee, Pegah; Gholami Fesharaki, Mohammad; Asgharinia, Mansour; Alavian, Seyed Moayed

    2013-01-01

    Background Zinc deficiency has been reported frequently in hepatitis C patients in the literature. Furthermore, a decrease in zinc level has been shown in beta thalassemia major as well. Iranians consume a large amount of phytate in their regimens which can bind with zinc and decrease its gastrointestinal absorption. Objectives This study was designed to determine plasma zinc level in an Iranian sample with the diagnosis of hepatitis C with or without concomitant beta thalassemia major. Patients and Methods Between April 2011 and April 2012, plasma zinc level was determined via atomic absorption method, in 130 hepatitis C patients with or without beta thalassemia major in a known referral center of hepatic diseases in Tehran, Iran. Results Mean ± standard deviation (SD) of plasma zinc levels was determined as 0.78 ± 0.22 mg/L. Also zinc level was 0.76 ± 0.19 mg/L and 0.80 ± 0.24 mg/L in thalassemic and non thalassemic patients, respectively. T-test analysis showed that there is no significant difference between these two groups regarding plasma zinc level (P = 0.235). Conclusions It is concluded that zinc level of studied patients is less than which is reported in normal Iranian population. Moreover, there is not a significant difference in plasma zinc levels between thalassemic and non thalassemic patients and it seems to be a common problem in both ones. Addition of zinc supplement may be recommended in both groups in order to optimize the nutritional support and probably improve the treatment response. PMID:24130600

  1. Beta-thalassemia

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    Origa Raffaella

    2010-05-01

    Full Text Available Abstract Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world and 1 in 10,000 people in the European Union. Three main forms have been described: thalassemia major, thalassemia intermedia and thalassemia minor. Individuals with thalassemia major usually present within the first two years of life with severe anemia, requiring regular red blood cell (RBC transfusions. Findings in untreated or poorly transfused individuals with thalassemia major, as seen in some developing countries, are growth retardation, pallor, jaundice, poor musculature, hepatosplenomegaly, leg ulcers, development of masses from extramedullary hematopoiesis, and skeletal changes that result from expansion of the bone marrow. Regular transfusion therapy leads to iron overload-related complications including endocrine complication (growth retardation, failure of sexual maturation, diabetes mellitus, and insufficiency of the parathyroid, thyroid, pituitary, and less commonly, adrenal glands, dilated myocardiopathy, liver fibrosis and cirrhosis. Patients with thalassemia intermedia present later in life with moderate anemia and do not require regular transfusions. Main clinical features in these patients are hypertrophy of erythroid marrow with medullary and extramedullary hematopoiesis and its complications (osteoporosis, masses of erythropoietic tissue that primarily affect the spleen, liver, lymph nodes, chest and spine, and bone deformities and typical facial changes, gallstones, painful leg ulcers and increased predisposition to thrombosis. Thalassemia minor is clinically asymptomatic but some subjects may have moderate anemia. Beta-thalassemias are caused by point mutations or, more rarely, deletions in the beta globin gene on chromosome 11, leading to reduced (beta+ or absent (beta0 synthesis of the beta chains of hemoglobin (Hb. Transmission is autosomal recessive; however, dominant mutations have also been reported. Diagnosis of thalassemia is based on hematologic and molecular genetic testing. Differential diagnosis is usually straightforward but may include genetic sideroblastic anemias, congenital dyserythropoietic anemias, and other conditions with high levels of HbF (such as juvenile myelomonocytic leukemia and aplastic anemia. Genetic counseling is recommended and prenatal diagnosis may be offered. Treatment of thalassemia major includes regular RBC transfusions, iron chelation and management of secondary complications of iron overload. In some circumstances, spleen removal may be required. Bone marrow transplantation remains the only definitive cure currently available. Individuals with thalassemia intermedia may require splenectomy, folic acid supplementation, treatment of extramedullary erythropoietic masses and leg ulcers, prevention and therapy of thromboembolic events. Prognosis for individuals with beta-thalassemia has improved substantially in the last 20 years following recent medical advances in transfusion, iron chelation and bone marrow transplantation therapy. However, cardiac disease remains the main cause of death in patients with iron overload.

  2. Beta-thalassemia, HB S-beta-thalassemia and sickle cell anemia among Tunisians.

    Science.gov (United States)

    Fattoum, S; Guemira, F; Oner, C; Oner, R; Li, H W; Kutlar, F; Huisman, T H

    1991-01-01

    We analyzed the mutations present in 19 patients with beta-thalassemia major, in 11 patients with Hb S-beta-thalassemia, and the beta S haplotypes of 34 patients with sickle cell anemia. The study included 84 relatives. Dot-blot analysis of amplified DNA with various specific oligonucleotide probes identified 11 different known beta-thalassemia mutations and frameshifts; a new frameshift at codons 25/26 (+T) was detected through sequencing of amplified DNA. The common beta-thalassemia mutations at codon 39 (C----T) and at IVS-I-110 (G----A) were also most prevalent among the Tunisian patients, while the milder T----C mutation at IVS-I-6 was not found. All mutations cause a beta 0-thalassemia or a severe beta + -thalassemia [T----A at -30; IVS-I-5 (G----A); IVS-I-110 (G----A)] which explains the need for regular blood transfusions in the thalassemia major and S-beta-thalassemia patients. Nearly all sickle cell anemia patients carried the beta S mutation on a chromosome with haplotype 19 (or Benin) and all had severe anemia with sickling complications. Identification of the beta S haplotype was through dot-blot analysis with oligonucleotide probes that detect mutations in the G gamma and A gamma promoter sequences, specific for this haplotype. PMID:1917531

  3. Beta Thalassemia (For Parents)

    Science.gov (United States)

    ... both parents are carriers of the beta thalassemia disorder, doctors can conduct tests on a fetus before birth. This is done through either: chorionic vilius sampling , which takes place ... could have a significant blood disorder (such as a form of sickle cell disease ...

  4. Major Beta-thalassemia: Protective or predisposing Factor for Cardiovascular Diseases

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    Mitra Kazemi Jahromi

    2011-01-01

    Full Text Available Introduction: Cardiac dysfunctions have been well known in patients with Major thalassemia. Some studies have focused on differences in blood pressure and heart rate between these patients and normal population, while this view has not been proven in other studies. Given the importance of hemodynamic factors in the health of these individuals, we intend to test the hypothesis as to whether or not hemodynamic factors of these patients differ from normal subjects.Methods: Patients were selected from among the thalassemic patients referred to a blood clinic of one of the third-level hospitals in Tehran. Finally, 50 patients and 50 normal subjects were studied in two groups. All subjects have been assessed using Holter monitoring. Mean average systolic blood pressure and heart rate of subjects were recorded for a period of 24 hours.In addition, demographic data on the subjects, and some laboratory tests (such as serum lipid profile and glucose levels of the patients were also determined and compared between the two groups.Results: 100 people were evaluated in two groups, including 50 patients with thalassemia major and 50 normal subjects, matched by age and gender. The mean age of the subjects was 16.3 ± 6.7 years; and there is no significant difference in mean age of both groups.23 female patients (46% were in the case group, and 21 female patients (42% were in the healthy group, the ratio for which there is no statistically significant difference between the two groups (P> 0. 05. The average level of serum glucose, lipid profiles, as well as none of the hemodynamic factors had no statistically significant difference in the two groups.Only the mean systolic blood pressure was significantly lower in male patients than among men without the disease. Discussion: Despite the lack of difference in blood pressure between the case group and others, it seems that gender could plays a protective role against cardiovascular diseases in men with thalassemia major.

  5. Post-transfusion hypertension, convulsion and intracranial haemorrhage in beta-thalassemia major

    International Nuclear Information System (INIS)

    The haematologic disorder b-thalassemia major is common in Pakistan. We describe a patient with undiagnosed thalassemia presenting with hypertension and convulsions and found to have cerebral haemorrhage on neuro-imaging. He had been transfused 2 weeks before this illness. Our experience is similar to a few case reports described in literature that were found to have cerebral haemorrhages post-mortem after a similar clinical presentation. All patients had a blood transfusion within 2 weeks prior to the presentation so association with transfusion has been proposed. We have reviewed the several mechanisms presented and discussed the findings. (author)

  6. ASSESSMENT OF THYROID FUNCTION IN CHILDREN WITH BETA - THALASSEMIA MAJOR AND ITS CORRELATION WITH SERUM FERRITIN AND TRANSFUSION INDEX

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    Ritu

    2014-01-01

    Full Text Available BACKGROUND : Beta - thalassemia syndromes are a group of hereditary blood disorders characterized by reduced or absent beta globin chain synthesis , resulting in transfusion dependent severe anemia , leading to iron overload , resulting in hypothyroidism as the most common endocrine problem. OBJECTIVE : There is lack of information about frequency of hypothyroidism in thalassemic patients in ce ntral part of India , so this was undertaken to determine the frequency of hypothyroidism in patients suffering from homozygous ß - thalassemia and to study its correlation with serum ferritin and transfusion index. METHOD : This descriptive study included 60 diagnosed thalassemia major patients aged 2 - 18 years. Demographic data as well as history of blood transfusion , from which transfusion index was estimated , was taken. Serum total T3 , T4 and TSH by sandwich ELISA method using Eliscan kit , serum ferritin lev el by sandwich ELISA method using Accu - bind kit were measured from fasting blood sample. Hypothyroidism was defined by a TSH level >6.4?IU/ml. RESULTS: Study of the thyroid panel among all 60 patients showed a mean TSH level of 4.65±2.41 ?IU/ml. Mean total T3 and total T4 levels were 1.35±0.48 ng/ml and 7.4±1.93 ?g/dl respectively. Mean serum ferritin level was 557.25±198.66 ng/dl. Hypothyroidism was detected in 14 (23.33% out of 60 ? thalassemia patients. Out of these , compensated hypothyroid (normal T3 a nd T4 with raised TSH was seen in 9 patients (15% and decompensated hypothyroid (Decrease T3 or T4 and Raised TSH was seen in 5 patients (8.33%. There was significant positive correlation of TSH levels with serum ferritin levels , age and transfusion in dex. However total T3 and total T4 did not show any correlation with serum ferritin levels , age or transfusion index. CONCLUSION : Hypothyroidism , are more common in second decade of life. Early recognition and hence prevention of these complications will d efinitely help to improve both the longevity & quality of life of these patients.

  7. Antioxidant status in beta thalassemia major: A single-center study

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    Faiza Waseem

    2011-01-01

    Full Text Available Background: Homozygous ? thalassemia may lead to a marked reduction or absence of normal ? chain production and accumulation of unpaired alpha-globin chains. A crucial component in the oxidant susceptibility of the thalassemic RBC is the release of heme and iron from the excessive, unpaired ?-globin chains. This release can initiate self-amplifying redox reactions, which deplete the cellular reduction potential (e.g., GSH, oxidize additional hemoglobin and accelerate RBC destruction. Furthermore, ?-thalassemia patients are under continuous blood transfusion, which, although life-saving, leads to an iron overload with a resultant increase in non-transferrin-bound iron that may cause greater tissue toxicity than iron in other forms. Iron-induced oxidative stress is known to be one of the most important factors determining cell injury in thalassemic patients. Therefore, we designed this study to obtain a comprehensive picture of the iron overload, antioxidant status and cell damage in ? thalassemia major patients undergoing regular blood transfusion. Materials and Methods: A total of 48 diagnosed patients of ? thalassemia major and 30 age- and sex-matched healthy subjects were included in the study. Estimation of hemoglobin, hematocrit, glutathione peroxidase (GPX, superoxide dismutase (SOD,vitamin E, serum ferritin, total and direct bilirubin, AST and ALT was carried out. Results: The levels of vitamin E, antioxidant enzymes GPX and SOD were significantly lowered in ? thalassemic patients as compared with the control group (P<0.001. Serum total and direct bilirubin, AST and ALT were significantly elevated in thalassemic subjects as compared with the control group, indicating liver cell damage. Conclusion: Thus, our findings indicate that thalassemics are in a state of enhanced oxidative stress and that the administration of selective antioxidants would represent a promising approach toward counteracting oxidative damage and its deleterious effects on the disease status.

  8. The Correlation between Troponin and Ferritin Serum Levels in the Patients with Major Beta-Thalassemia

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    Iraj Shahramian

    2013-06-01

    Full Text Available Background: Thalassemia is a hereditary hemoglobinopathy whose most common complication is cardiac involvement which ends up in these patients’ death. Since troponin is a sensitive and specific marker for the detection of microinfarct, we studied the relationship between troponin and ferritin serum levels for early diagnosis of cardiac involvement in these patients. Materials and Methods: This case-control study was performed on 80 patients, including 40 patients with major thalassemia and normal echocardiography and 40 healthy volunteers ranging from 6 months to 16 years old. All the children were examined and the eligible children who were not infected with known heart disease, iron deficiency anemia, kidney disease, diabetes, fever, and systemic diseases were enrolled into the study after obtaining written informed consents from their parents. At 8:00 A.M. before breakfast, 5cc blood was drawn from these children. After collecting the samples, ferritin and troponin serum levels were evaluated using ELISA and electro- kymonolonsense methods, respectively. The gathered data were analyzed through the SPSS statistical software (v. 20 and T-test. Besides, P value<0.05 was considered as statistically significant. Results: The study results revealed a significant difference between the two groups regarding the mean of the serum levels of troponin (P=0.045 and ferritin (P=0.001. In this study, no significant correlation was observed between serum troponin and ferritin levels and age and BMI in the two groups. Also, no significant relationship was found between serum troponin level and sex (P=0.264. Conclusions: In microinfarct, troponin increases independent of ferritin; therefore, it can be used for early detection of cardiac involvement in thalassemia patients to determine the sub-clinical effects.

  9. Application of Single Strand Conformational Polymorphism (PCR-SSCP) in Identification of Some Beta-Globin Gene Mutations in A Group of Egyptian Beta-Thalassemia Patients and Carriers

    International Nuclear Information System (INIS)

    The present study investigated whether the single-strand conformational polymorphism (SSCP) method could be employed to identify (rather than simply detect) four of the most common beta-globin gene mutations in the Egyptian population: IVS-I-110, IVS-I-6, the IVS-I-1, and Codon 39. Using DNA from 90 beta-thalassemia patients and carriers, by PCR the appropriate 238-bp region of the human beta-globin gene was amplified, the reaction products (Single-stranded DNA) were analyzed by none denaturing polyacrylamide gel electrophoresis, and the bands visualized by silver staining. Single-stranded DNA (ssDNA) fragments showed reproducible pattern of bands that were characteristic of the mutations present. With the use of control samples containing six of the 10 possible combinations of the four beta-globin gene mutations under study, we were able to predict the mutations present in 23 out of 90 (26.4%) of the patients studied. These predictions were confirmed independently by the amplification refractory mutation system (ARMS) method. It is concluded that this non-radioactive PCR-SSCP method can be used to reliably identify mutations in beta-thalassemia patients, provided that suitable controls are available. However, usefulness of this method for determining the genotype of beta-thalassaemic individuals is obviously limited by the great number of controls required. Moreover, the ability to detect mutations by SSCP is in general lower compared to other methods, ARMS, DGGE or DHPLC, which are reported to detect 49.5% to 73% of the mutations present. The SSCP method is nevertheless much easier to employ than other methods and is especially successful for beta-thalassemia carriers. This method would thus be particularly useful for an initial screening of target groups (prenatal diagnosis)

  10. Co-existence of Phenylketonuria (PKU) and beta-Thalassemia Major in a 16 Years Old Girl: A Case Report

    OpenAIRE

    Hossein Karami; Mehrnoush Kosaryan; Aili Aliasgharian; Ali Abbaskhanian; Rayka Sharifian; Mehrdad Taghipour

    2012-01-01

    While thalassemia major (TM) used to be a prevalent genetic disease in the past, however, (PKU) is quite rare in spite of consanquiness marriage rate of about 40% in the region. Preventive efforts for TM started >20 years ago but neonatal screening for PKU started since 2007. This is the first report of co-existence of thalassemia and PKU in Middle East and in consideration of the prevalence of each genes, this chance association is a very unusual event. We report a case of having PKU and TM

  11. Pentraxin-3 Levels in Beta Thalassemia Major and Minor Patients and Its Relationship With Antioxidant Capacity and Total Oxidant Stress.

    Science.gov (United States)

    Isik Balci, Yasemin; Nuray, Esin; Polat, Aziz; Enli, Yaşar; Ozgurler, Funda; Akin, Mehmet

    2016-01-01

    Thalassemia major (TM) results in hemolytic anemia, an increase in intestinal iron absorption, and occurrence of iron loading due to erythrocyte transfusion; the disease is characterized by oxidative damage in major organs. Oxidative stress leads to vascular endothelial damage and forms the basis for serious cardiovascular diseases. Pentraxin-3 (PTX-3) is one of the markers of vascular endothelial damage that increases in response to the oxidative stress, which can be used as an early diagnostic marker for inflammation. This study's purpose is to define the relation between PTX-3 and the vascular endothelial damage that increases with oxidative stress in thalassemia patients. Our study included 35 TM patients, 30 β-thalassemia minor patients, and 30 healthy children. As a result of our study, in TM patients, a positive relation was detected between the PTX-3 levels and the total oxidative stress, triglyceride, and very low-density lipoprotein values, whereas a negative relation was detected with the total antioxidant capacity and high-density lipoprotein values. This result shows that as oxidant stress increases, PTX-3 levels also increase; very low-density lipoprotein and triglyceride contribute to the endothelial damage occurring with oxidative stress. As a result, it was concluded that vascular endothelial damage in thalassemia patients can be evaluated through the serum PTX-3 level. PMID:26599985

  12. The pro-BNP Serum Level and Echocardiographic Tissue Doppler Abnormalities in Patients with Beta Thalassemia Major

    Science.gov (United States)

    Garadah, Taysir S.; Mahdi, Najat; Kassab, Salah; Shoroqi, Isa Al; Abu-Taleb, Ahmed; Jamsheer, Anwer

    2010-01-01

    Background Doppler echocardiographic studies of the left ventricle (LV) function in patients with ?-Thalassemia Major (?-TM) had shown different patterns of systolic and diastolic dysfunctions associated with abnormal serum brain natriuretic peptide (BNP). Aim This cross-sectional study was designed to study the LV systolic and diastolic functions and correlate that with serum level of N-terminal pro brain natriuretic hormone (NT- pro BNP) in patients with ?-TM using Pulsed Doppler (PD) and Tissue Doppler (TD) echocardiography. Methods The study was conducted on patients with ?-TM (n = 38, age 15.7 ± 8.9 years) and compared with an age-matched controls (n = 38, age 15.9 ± 8.9 years). In all participants, PD and TD echocardiography were performed and blood samples were withdrawn for measuring the serum level of NT-pro BNP, ferritin, and alanine transaminase. Results Patients with ?-TM compared with controls, have thicker LV septal wall index (0.65 ± 0.26 vs. 0.44 ± 0.21 cm, P < 0.001), posterior wall index (0.65 ± 0.23 vs. 0.43 ± 0.21 cm, P < 0.01), and larger LVEDD index (4.35 ± 0.69 vs.3.88 ± 0.153 mm, P < 0.001). In addition, ?-TM patients have higher transmitral E wave velocity (E) (70.818 ± 10.139 vs. 57.532 ± 10.139, p = 0.027) and E/A ratio (1.54 ± 0.17 vs. 1.23 ± 0.19, P < 0.01) and shorter deceleration time (DT) (160.13 ± 13.3 vs. 170.50 ± 19.20 m sec, P < 0.01). Furthermore, the ratio of transmitral E wave velocity to the tissue Doppler E wave at the basal septal mitral annulus (E/Em?) was significantly higher in ?-TM group (19.6 ± 2.81 vs. 13.868 ± 1.41, P < 0.05). The tissue doppler systolic wave (Sm) velocity and the early diastolic wave (Em) were significantly lower in ?-TM group compared to controls (Sm: 4.82 ± 1.2 vs. 6.22 ± 2.1 mm/sec, P < 0.05; Em: 3.51 ± 2.7 vs. 4.12 ± 2.5 mm/sec P < 0.05, respectively). The tricuspid valve velocity was significantly higher in ?-TM patients compared with controls (2.993 ± 0.569 vs. 1.93 ± 0.471 m/sec, respectively, P < 0.01). The mean serum NT pro-BNP in ?-TM was significantly higher compared with controls (37.6 ± 14.73 vs. 5.5 ± 5.4pg/ml, P < 0.05). The left ventricle ejection fraction (EF%) and fractional shortening (FS%) were not significantly different between both groups. Conclusion We conclude that patients with ?-TM had a significantly higher serum level of NT-pro BNP that is positively correlated with the E/Em ratio on tissue Doppler. Furthermore, we confirm our previous findings that patients with ?-TM exhibit LV diastolic pattern on echocardiogram suggestive of restrictive type with well preserved left ventricle systolic function. PMID:21234293

  13. [Beta-thalassemias: molecular, epidemiological, diagnostical and clinical aspects].

    Science.gov (United States)

    Joly, Philippe; Pondarre, Corinne; Badens, Catherine

    2014-01-01

    Beta-thalassemia is one of most common autosomal recessive disorders worldwide. In France, 5 to 10 new major or intermedia forms are diagnosed annually and the global prevalence is about 500 cases. Since 20 years and thanks to the generalization of iron chelator treatments, the life expectancy has dramatically increased. Nearly 90% of the ?-thalassemic alleles are point mutations easily identified by Sanger sequencing or dedicated methods. The remaining 10% are deletions detectable by MLPA or CGH Array. The alpha-globin genotype is also essential in the exploration of beta-thalassemia because an alpha-thalassemia improves the clinical state whereas an alpha triplication worsens it. The additional genotyping of a few HbF inducer polymorphisms allows to predict the age of the first transfusion, thanks to a recent dedicated algorithm, making beta-thalassemia one of the first potential application of predictive medicine. Gene therapy, pre-implantatory diagnosis and new drugs (Sotatercept®, hepcidin-like molecules) have also recently contributed to make beta-thalassemia a main scientific topic again. PMID:25486662

  14. [Osteoarthropathy in beta-thalassemia].

    Science.gov (United States)

    Musaev, S K; Iakovleva, G I; Nasonova, V A; Smirnov, A V; Abasov, E Sh; Efendieva, E G

    1991-01-01

    A total of 45 patients with beta-thalassemia and 30 patients with thalassemia intermedia underwent clinical and x-ray examinations. Electron microscopy was used to examine biopsy specimens of the synovial membrane from 6 patients with homozygous thalassemia intermedia. It has been revealed that damage to the osseous system and joints is of systemic nature and depends on the clinical form of the pathological process. Morphological methods have demonstrated abnormal metabolism of iron with its deposition in the tissues and impairment of the vessels of the microcirculatory bed. PMID:1887421

  15. Effects of the anti-receptor activator of nuclear factor kappa B ligand denusomab on beta thalassemia major-induced osteoporosis

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    Mohamed A Yassin

    2014-01-01

    Full Text Available Introduction: Osteoporosis represents the second most common cause of endocrinopathy in patients with beta thalassemia major (BTM. Some drugs proved effective to reduce vertebral and non-vertebral fracture risk. Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor kappa B ligand (RANKL, a member of the tumor necrosis factor receptor superfamily essential for osteoclastogenesis. The efficacy and safety of denosumab in BTM-induced osteoporosis has not been tested. Objective: To evaluate the efficacy and safety of anti-RANKL on the biochemical and radiological parameters of bone mineralization in patients with BTM-induced osteoporosis. Design: The study population was selected using the random sampling method from the patient?s database of our thalassemia clinic. Transfusion-dependent BTM patients above 18 years with no history of treatment with bisphosphonates were randomly selected. Bone mineral density (BMD of the lumbar spine (LS and right femoral neck (FN were measured by dual energy X-ray absorption (DEXA scan using a calibrated method. Independent factors likely to be associated with low bone mass were determined and included in the analysis to ascertain possible associations. Patients and Methods: We studied 30 patients with BTM-induced osteoporosis as per World Health Organization criteria (T Score of less than ? 1.0 being defined as osteopenic and a T Score of less than ? 2.5 being referred as osteoporotic. 19 males and 11 females aged between 18 and 32 years, with full pubertal development (Tanner?s stage 5 at the time of the study. Their mean serum ferritin concentration was 3557 ng ± 1488 ng/ml. Every patient underwent DEXA scan as a baseline and after 12 months of denosumab therapy. Biochemical evaluation including serum concentrations of creatinine, Na, K, calcium, phosphorus, parathormone, bone specific alkaline phosphatase and type 1 collagen carboxy telopetide (ICCT using enzyme-linked immunosorbent assay (Nordic Bioscience Diagnostics A/S was done at baseline, after a month and then every 3 months for 12 months after starting denosumab. 60 mg of denosumab was administered subcutaneously twice yearly for a year. The mean BMD T Scores at baseline were ?2.7 at the LS and ?2.1 at the FN. Results: Denosumab therapy for a year was associated with a significant increase in BMD of 9.2% (95% confidence interval [CI], 8.2-10.1 at the LS and 6.0% (95% CI, 5.2-6.7 at the FN. Denosumab treatment decreased serum ICCT levels by 56% at 1 month and normalized them in all patients at 1 year. Significant correlations were found between BMD T Score before and 1 year after denosumab in LS (r = 0.752, P < 0.001 and FN (r = 0.758 P < 0.001, respectively. The most common side effects were pain in the back and extremities (12% and nausea (10%. Asymptomatic hypocalcaemia occurred in two patients. Conclusion: Denosumab therapy for a year significantly increased BMD density at LS and FN of patients with BTM and was associated with a rapid and sustained reduction in ICCT levels. Further studies are required to confirm long-term effects of this therapy.

  16. Sustained improvements in myocardial T2* over 2 years in severely iron-overloaded patients with beta thalassemia major treated with deferasirox or deferoxamine.

    Science.gov (United States)

    Pennell, Dudley J; Porter, John B; Piga, Antonio; Lai, Yong-Rong; El-Beshlawy, Amal; Elalfy, Mohsen; Yesilipek, Akif; Kilinç, Yurdanur; Habr, Dany; Musallam, Khaled M; Shen, Junwu; Aydinok, Yesim

    2015-02-01

    Long-term controlled studies are needed to inform on the clinical benefit of chelation therapy for myocardial iron removal in transfusion-dependent beta thalassemia patients. In a 1-year nonrandomized extension to the CORDELIA study, data collected from patients with myocardial siderosis provided additional information on deferasirox or deferoxamine (DFO) efficacy and safety. Myocardial (m)T2* increased from baseline 11.6 to 15.9 ms in patients receiving deferasirox for 24 months (n = 74; geometric mean [Gmean ] ratio of month 24/baseline 1.38 [95% confidence interval 1.28, 1.49]) and from 10.8 to 14.2 ms in those receiving DFO (n = 29; Gmean ratio 1.33 [1.13, 1.55]; P = 0.93 between groups). Improved mT2* with deferasirox was evident across all subgroups evaluated irrespective of baseline myocardial (mT2* deferasirox or DFO. Liver iron concentration decreased from high baseline values of 30.6 ± 18.0 to 14.4 ± 16.6 mg Fe/g dw at month 24 in deferasirox patients and from 36.8 ± 15.6 to 11.0 ± 12.1 mg Fe/g dw in DFO patients. The long-term safety profile of deferasirox or DFO was consistent with previous reports; serious drug-related AEs were reported in 6.8% of deferasirox and 6.9% of DFO patients. Continued treatment of severely iron-overloaded beta thalassemia patients with deferasirox or DFO led to sustained improvements in myocardial iron irrespective of high or low baseline myocardial or liver iron burden, in parallel with substantial improvements in liver iron (Clinicaltrials.gov identifier: NCT00600938). PMID:25345697

  17. Plastic bronchitis in beta thalassemia minor

    OpenAIRE

    Yadav, Makaresh; Tirpude, Sneha; Joshi, Jyotsna M.

    2013-01-01

    Plastic bronchitis is a rare pulmonary disorder associated with various conditions like cystic fibrosis, asthma, pulmonary infection and characterized by formation and expectoration of cast which assumes the shape of the bronchial tree. We report a case of a 33-year-old woman with beta thalassemia minor who developed plastic bronchitis.

  18. Plastic bronchitis in beta thalassemia minor

    Directory of Open Access Journals (Sweden)

    Makaresh Yadav

    2013-01-01

    Full Text Available Plastic bronchitis is a rare pulmonary disorder associated with various conditions like cystic fibrosis, asthma, pulmonary infection and characterized by formation and expectoration of cast which assumes the shape of the bronchial tree. We report a case of a 33-year-old woman with beta thalassemia minor who developed plastic bronchitis.

  19. Plastic bronchitis in beta thalassemia minor

    Science.gov (United States)

    Yadav, Makaresh; Tirpude, Sneha; Joshi, Jyotsna M.

    2013-01-01

    Plastic bronchitis is a rare pulmonary disorder associated with various conditions like cystic fibrosis, asthma, pulmonary infection and characterized by formation and expectoration of cast which assumes the shape of the bronchial tree. We report a case of a 33-year-old woman with beta thalassemia minor who developed plastic bronchitis. PMID:24049256

  20. Hematology of a murine. beta. -thalassemia: a longitudinal study

    Energy Technology Data Exchange (ETDEWEB)

    Popp, R.A.; Popp, D.M.; Johnson, F.M.; Skow, L.C.; Lewis, S.E.

    1986-01-01

    Mice homozygous for a spontaneous mutation, in which the ..beta..-major globin gene is deleted, have clinical symptoms of ..beta..-thalassemia. These mice have a hypocellular, hypochromic, microcytic anemia that becomes more severe with increasing age. The defective red cell morphology, decreased osmotic fragility of erythrocytes and shortened red cell life span found in ..beta..-thalassemic mice are similar to those observed in human ..beta..-thalassemia. Synthesis of ..beta..-globin is depressed but not as much as might be expected because the expression of the..beta..-minor globin gene is enhanced to encode two to three times more globin than in normal mice. Splenomegaly, an enlarged pool of stem cells for erythropoiesis, and iron overloading occur in older mice. The fact that these mice remain moderately healthy makes them a very suitable animal model in which to develop and test alternative techniques of gene therapy that could be successfully applied to the treatment of human thalassemia. Homozygous ..beta..-thalassemic mice have large deposits of iron in their tissues, which might make these mice also useful for in vivo tests of the effectiveness and possible long-term side effects for newly developed iron chelators.

  1. Renal tubular dysfunction nephrocalcinosis in a patient with BetaThalassemia Minor

    International Nuclear Information System (INIS)

    Thalassemia is a hereditary anemia resulting from defect in hemoglobinproduction. Beta thalassemia is due to impaired production. Beta thalassemiais due to impaired production of beta globin chains, leading to a relativeexcess of alpha globin chains. The term beta thalassemia minor is used todescribe heterozygotes, who carry one normal beta globin and one betathalassemic allele. The vast majority of these patients are asymptomatic.However, a variety of renal tubular abnormalities including hypercaliuria,hypomagnesemia with renal magnesium wasting, decreased tubular absorption ofphosphorous, hypouricemia with renal uric acid wasting, renal glycosuria andtubular proteinuria have been described even in patients with betathalassemia minor. We here in report a 24-year old patient who was found tohave thalassemia minor and nephrocalcinosis with evidence of renal tubulardysfunction. Investigations revealed normal renal function, hypercalciuria,reduced tubular reabsorption of phosphorous, hypomagnesemia and renalmagnesium wasting. Screening for aminoaciduria was found to be negative. Anacid loading test revealed normal urinary acidification. Ultrasonogram of theabdomen revealed nephrocalcinosis and splenomegaly. Detailed work up foranemia showed normal white cell and platelet count while peripheral smearshowed microcytic hypochromic anemia with few target cells. Hemoglobinelectrophoresis revealed hemoglobin A of 92%, hemoglobin A2 of 6.2% andhemoglobin F of 1.8% consistent with beta thalassemia minor. Her parentalscreening was normal. A diagnosis of beta thalassemia minor with renaltubular dysfunction was made and the patient was started on thiazidediuretics to reduce hypercalciuria and advised regular follow-up. (author)

  2. EXERCISE STRESS ECHOCARDIOGRAPHY WITH TISSUE DOPPLER IMAGING (TDI) DETECTS EARLY SYSTOLIC DYSFUNCTION IN BETA-THALASSEMIA MAJOR PATIENTS WITHOUT CARDIAC IRON OVERLOAD

    OpenAIRE

    Umberto Barbero

    2012-01-01

    Iron Overload Cardiomyopathy (IOC) is still the main cause of death in thalassemia major (TM) patients. Unfortunately, Conventional Echocardiography fails to predict early cardiac dysfunction. As Tissue Doppler Imaging (TDI) may demonstrate regional myocardial dysfunction, we wondered if exercise may reveal abnormalities at TDI which are not evident at rest. To try to evaluate left and right myocardial performances at rest and after maximal exercise by both conventional and TDI param...

  3. Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor

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    Prabahar Murugesan

    2008-01-01

    Full Text Available Thalassemia is a hereditary anemia resulting from defect in hemoglobin production. Beta thalassemia is due to impaired production of beta globin chains, leading to a relative excess of alpha globin chains. The term beta thalassemia minor is used to describe heterozygotes, who carry one normal beta globin allele and one beta thalassemic allele. The vast majority of these patients are asymptomatic. However, a variety of renal tubular abnormalities including hypercalciuria, hypo-magnesemia with renal magnesium wasting, decreased tubular absorption of phosphorus, hypo-uricemia with renal uric acid wasting, renal glycosuria and tubular proteinuria have been described even in patients with beta thalassemia minor. We here in report a 24-year old female patient who was found to have thalassemia minor and nephrocalcinosis with evidence of renal tubular dysfunction. Investigations revealed normal renal function, hypercalciuria, reduced tubular reabsorption of phos-phorus, hypomagnesemia and renal magnesium wasting. Screening for aminoaciduria was found to be negative. An acid loading test revealed normal urinary acidification. Ultrasonogram of the abdomen revealed nephrocalcinosis and splenomegaly. Detailed work up for anemia showed normal white cell and platelet count while peripheral smear showed microcytic hypochromic anemia with few target cells. Hemoglobin electrophoresis revealed hemoglobin A of 92%, hemoglobin A2 of 6.2% and hemo-globin F of 1.8% consistent with beta thalassemia minor. Her parental screening was normal. A diag-nosis of beta thalassemia minor with renal tubular dysfunction was made and the patient was started on thiazide diuretics to reduce hypercalciuria and advised regular follow-up.

  4. Pancreatic functions in adolescents with beta thalassemia major could predict cardiac and hepatic iron loading: relation to T2-star (T2*) magnetic resonance imaging.

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    Mokhtar, Galila M; Ibrahim, Wafaa E; Elbarbary, Nancy S; Matter, Randa M; Ibrahim, Ahmed S; Sayed, Safa M

    2016-03-01

    The aim of this study is to assess the correlation between cardiac and hepatic T2* MRI findings with the endocrine and exocrine pancreatic functions in known patients with ?-thalassaemia major (?-TM). A total of 50 adolescent patients with ?-TM and 44 healthy controls were investigated via: serum amylase, lipase, triglyceride index, oral glucose tolerance test and T2* MRI, to assess iron content in the heart and liver. Diabetes was found in 20%, and 40% of patients had impaired fasting glucose (IFG). Cardiac T2* was less than 10?ms in 22% indicating heavy load with iron in cardiac tissues. There was a significant decrease in median serum amylase (63.5 vs 87.5?IU/L, p=0.003) and lipase (63 vs 90?IU/L, p=0.017) among patients in comparison with the control group. Patients with ?-TM and diabetes had lower serum amylase (32 vs 68?IU/L), lipase (28 vs 79?IU/L), cardiac and hepatic T2* MRI (7 vs 25.5?ms; 3 vs 6?ms, pamylase (r=0.791 and r=0.790) and lipase (r=0.784 and r=0.783; p<0.001 for all). The endocrine and exocrine pancreatic functions might become an equivalent predictor to cardiac and hepatic iron overload, especially in countries where MRI is not available or where it is expensive. The early occurrence of these abnormalities warrants more intensive chelation therapy. PMID:26912010

  5. Detection of glycemic abnormalities in adolescents with beta thalassemia using continuous glucose monitoring and oral glucose tolerance in adolescents and young adults with ?-thalassemia major: Pilot study

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    Ashraf T Soliman

    2013-01-01

    Full Text Available Background: Both insulin deficiency and resistance are reported in patients with ?-thalassemia major (BTM. The use of continuous blood glucose monitoring (CGM, among the different methods for early detection of glycemic abnormalities, has not been studied thoroughly in these adolescents. Materials and Methods: To assess the oralglucose tolerance (OGT and 72-h continuous glucose concentration by the continuous glucose monitoring system (CGMS and calculate homeostatic model assessment (HOMA, and the quantitative insulin sensitivity check index (QUICKI was conducted in 16 adolescents with BTM who were receiving regular blood transfusions every 2-4 weeks and iron-chelation therapy since early childhood. Results: Sixteen adolescents with BTM (age: 19.75 ± 3 years were investigated. Using OGTT, (25% had impaired fasting blood (plasma glucose concentration (BG (>5.6 mmol/L. 2-h after the glucose load, one of them had BG = 16.2 mmol/L (diabetic and two had impaired glucose tolerance (IGT (BG > 7.8 and 11.1 mmol/L and 9 with IGT (56%. HOMA and QUICKI revealed levels 0.33 (0.36 ± 0.03, respectively, ruling out significant insulin resistance in these adolescents. There was a significant negative correlation between the ?-cell function (B% on one hand and the fasting and the 2-h BG (r=?0.6, and ? 0.48, P < 0.01, respectively on the other hand. Neither fasting serum insulin nor c-peptide concentrations were correlated with fasting BG or ferritin levels. The average and maximum blood glucose levels during CGM were significantly correlated with the fasting BG (r = 0.68 and 0.39, respectively, with P < 0.01 and with the BG at 2-hour after oral glucose intake (r = 0.87 and 0.86 respectively, with P < 0.001. Ferritin concentrations were correlated with the fasting BG and the 2-h blood glucose levels in the OGTT (r = 0.52, and r = 0.43, respectively, P < 0.01 as well as with the average BG recorded by CGM (r = 0.75, P < 0.01. Conclusion: CGM has proven to be superior to OGTT for the diagnosis of glycemic abnormalities in adolescents with BTM. Defective ?-cell function rather than insulin resistance appeared to be the cause for these abnormalities.

  6. Pulmonary dysfunction in beta thalassemia

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    Neslihan Ozkul Saglam

    2015-01-01

    Full Text Available Objective: Lung involvement is one of known complications of thalassemia. The aim of our study was to determine predominant type of pulmonary dysfunction and its relationship to iron overload in ß thalassemia major patients, at the same time to investigate the presence of the bronchial hyperreactivity. Material and Methods: Twenty-seven patients, 15 (56 girls and 12 (44 boys, with ß thalassemia major who were followed up from pediatric hematology department were recruited in this study. The patients who were followed up at least for 2 years with ß thalasemia major, having repeated transfusion and chelation therapy, older than 6 years old and without history or signs of chronic lung disease have been included in this study. Pulmonary function test and metacholine bronchial provocation test have been carried out by the same team of technicians for all subjects. Results: The mean age of the patients were 11.3±3.81 years. The age of diagnosis was 1.82±2.1 years. Splenectomy was performed in 8 (29.6 patients. Pulmonary function tests were performed before transfusion and all parameters were normal in all of the patients. Transfusion duration, age, cummulative transfusion volume, ferritin levels, hemoglobin levels, presence of splenectomy and the presence of hepatomegaly were compared with pulmonary function tests. There was no significant relation between all these parameters and forced vital capacity (FVC, peak expiratory sow (PEF, forced expiratory volume in one second (FEV1, forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC and forced expiratory sow at 50 (FEF50 (p>0.05 except age which was correlated inversely with FVC (p=0.008. Forced vital capacity was also inversely correlated with weight and height of the patients (p=0.02, p=0.01. None of patients had bronchial hyperreactivity. Conclusion: Restrictive lung disease was the predominant abnormality in multi-transfused thalassemics found in our study. Our data suggest the need to include periodic lung function testing in follow up of all ß thalassemia patients. More studies are necessary to verify the reasons for these respiratory alterations.

  7. Oxidative stress and antioxidant status in beta-thalassemia heterozygotes

    Scientific Electronic Library Online (English)

    Luciana de Souza, Ondei; Isabeth da Fonseca, Estevao; Marina Ibelli Pereira, Rocha; Sandro, Percario; Doroteia Rossi Silva, Souza; Marcela Augusta de Souza, Pinhel; Claudia Regina, Bonini-Domingos.

    Full Text Available Background: Several studies have evaluated the oxidant and antioxidant status of thalassemia patients but most focused mainly on the severe and intermediate states of the disease. Moreover, the oxidative status has not been evaluated for the different beta-thalassemia mutations. Objective: To [...] evaluate lipid peroxidation and Trolox equivalent antioxidant capacity in relation to serum iron and ferritin in beta thalassemia resulting from two different mutations (CD39 and IVS-I-110) compared to individuals without beta-thalassemia. Methods: One hundred and thirty subjects were studied, including 49 who were heterozygous for beta-thalassemia and 81 controls. Blood samples were subjected to screening tests for hemoglobin. Allele-specific polymerase chain reaction was used to confirm mutations for beta-thalassemia, an analysis of thiobarbituric acid reactive species was used to determine lipid peroxidation, and Trolox equivalent antioxidant capacity evaluations were performed. The heterozygous beta-thalassemia group was also evaluated for serum iron and ferritin status. Results: Thiobarbituric acid reactive species (486.24 ± 119.64 ng/mL) and Trolox equivalent antioxidant capacity values (2.23 ± 0.11 mM/L) were higher in beta-thalassemia heterozygotes compared to controls (260.86 ± 92.40 ng/mL and 2.12 ± 0.10 mM/L, respectively; p-value

  8. Quality of life among Iranian patients with beta-thalassemia major using the SF-36 questionnaire / Qualidade de vida em pacientes iranianos com beta-talassemia maior usando o questionario SF-36

    Scientific Electronic Library Online (English)

    Sezaneh, Haghpanah; Shiva, Nasirabadi; Fariborz, Ghaffarpasand; Rahmatollah, Karami; Mojtaba, Mahmoodi; Shirin, Parand; Mehran, Karimi.

    Full Text Available CONTEXTO E OBJETIVO Pacientes com beta-talassemia maior (?-TM) vivenciam problemas físicos, psicológicos e sociais que levam à diminuição da qualidade de vida (QV). O objetivo foi determinar a QV relacionada à saúde e seus determinantes em pacientes com ?-TM, utilizando questionário SF-36 (Short Fo [...] rm-36). TIPO DE ESTUDO E LOCAL Estudo transversal no Centro de Hematologia e Pesquisa em Universidade de Ciências Médicas de Shiraz, no sul do Irã. MÉTODOS Foram selecionados aleatoriamente 101 pacientes com ?-TM. Após registro demográfico e características da doença, eles foram convidados a preencher o questionário SF-36. A correlação entre fatores clínicos e demográficos com escore de QV foi avaliada. RESULTADOS Havia 44 homens e 57 mulheres, com idade média de 19,52 ± 4,3 (variação 12-38) anos. Em duas escalas, dor (P = 0,041) e aspectos emocionais (P = 0,009), as mulheres apresentaram escores significativamente menores aos dos homens. Menor renda, baixa adesão à terapia quelante de ferro e presença de comorbidades foram correlacionadas com escores SF-36 significativamente menores. Esses fatores foram também considerados determinantes de piores escores de SF-36 em análise multivariada. CONCLUSÕES Mostramos que a presença de complicações da doença, a baixa adesão ao tratamento da terapia quelante de ferro e o baixo status econômico são preditores de pior QV em pacientes com ?-TM. Prevenção e manejo adequado das complicações relacionadas com a doença, aumento do conhecimento dos pacientes sobre a importância do gerenciamento de comorbidades e ter maior adesão ao tratamento quelante de ferro, considerando também o apoio psicossocial e financeiro, poderiam ser úteis para melhor lidar com esse estado de doença crônica. Abstract in english CONTEXT AND OBJECTIVE Patients with beta-thalassemia major (?-TM) experience physical, psychological and social problems that lead to decreased quality of life (QoL). The aim here was to measure health-related QoL and its determinants among patients with ?-TM, using the Short Form-36 (SF-36) questi [...] onnaire. DESIGN AND SETTING Cross-sectional study at the Hematology Research Center of Shiraz University of Medical Sciences, in southern Iran. METHODS One hundred and one patients with ?-TM were randomly selected. After the participants' demographics and disease characteristics had been recorded, they were asked to fill out the SF-36 questionnaire. The correlations of clinical and demographic factors with the QoL score were evaluated. RESULTS There were 44 men and 57 women of mean age 19.52 ± 4.3 years (range 12-38). On two scales, pain (P = 0.041) and emotional role (P = 0.009), the women showed significantly lower scores than the men. Lower income, poor compliance with iron-chelating therapy and presence of comorbidities were significantly correlated with lower SF-36 scores. These factors were also found to be determinants of worse SF-36 scores in multivariate analysis. CONCLUSIONS We showed that the presence of disease complications, poor compliance with iron-chelating therapy and poor economic status were predictors of worse QoL among patients with ?-TM. Prevention and proper management of disease-related complications, increased knowledge among patients regarding the importance of managing comorbidities and greater compliance with iron-chelating therapy, along with psychosocial and financial support, could help these patients to cope better with this chronic disease state.

  9. Premarital Screening of Beta Thalassemia Minor in north-east of Iran

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    Noori R MSc

    2013-03-01

    Full Text Available AbstractBackgroundBeta thalassemia is a preventable disease. Iran has about 20,000Patients who are homozygote for ?-thalassaemia and 3,750,000 carriers. The aim of this study was to determine the prevalence of beta thalassemia minor among men who underwent premarital screening in Quchana city in Khorasan Razavi region of IranMaterials and MethodsThis research is a descriptive cross-sectional study. From 2010 to 2011, all participants (1000 under marriage coming to health center of Quchan underwent routine mandatory tests. Participants were considered to have beta-thalassemia minor on the condition that hey had a mean corpuscular volume (MCV 3.5%. Venous blood was taken into an EDTA tube and the complete blood count and red blood cell indices were measured with a Coulter automated cellcounter. Electrophoresis was performed on cellulose acetate.ResultsMean and SD of hemoglobin, MCV and MCH were 16±2.9, 91±4 and 28.4±2, respectively. Hemoglobin A2 Higher than 3.5 percent was reported as 3.5%.The prevalence of beta-thassemia minor with high hemoglobin A2 and microcytic hypochromic anemia was 3.5% (P-value.ConclusionIn countries with high prevalence of hemoglobinopathies, a premarital screening program is helpful for identification and prevention of high-risk marriages. Detecting carrier couples with premarital screening program is an effective way of controlling thalassemia major.

  10. Survey of Hfe Gene C282Y Mutation in Turkish Beta-Thalassemia Patients and Healthy Population: A Preliminary Study

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    Ünal, Selma; Balta, Günay; Gümrük, Fatma

    2014-01-01

    Objective: This study was planned in order to determine the effect of C282Y mutation in development of secondary hemochromatosis in beta-thalassemia patients and to determine the prevalence and allele frequency of this mutation in a healthy control group. Materials and Methods: Eighty-seven children and young adults (46 males and 41 females; mean age: 15.6±6.1 years, range: 3-30 years) with beta-thalassemia major (BTM) and 13 beta-thalassemia intermedia (BTI) patients (6 males and 7 females; mean age: 19.6±3.5 years, range: 13-26 years) were included in the study. The control group comprised 100 healthy blood donors. Results: Neither heterozygous nor homozygous HFE gene C282Y mutation was detected in patients with BTM or BTI, or in control group. Conclusion: The C282Y mutation, which is supposed to be responsible for the majority of hereditary hemochromatosis, was not found to have a role in the development of hemochromatosis in beta-thalassemia patients and was not detected in a healthy Turkish population. However, research on larger cohorts of individuals is required in order to determine the exact prevalence of the HFE gene mutation in Turkish populations from diverse ethnic origins and whether it would have an impact on iron loading in thalassemic populations. PMID:25330520

  11. Survey of HFE Gene C282Y Mutation in Turkish Beta-Thalassemia Patients and Healthy Population: A Preliminary Study

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    Selma Ünal

    2014-09-01

    Full Text Available OBJECTIVE: This study was planned in order to determine the effect of C282Y mutation in development of secondary hemochromatosis in beta-thalassemia patients and to determine the prevalence and allele frequency of this mutation in a healthy control group. METHODS: Eighty-seven children and young adults (46 males and 41 females; mean age: 15.6±6.1 years, range: 3-30 years with beta-thalassemia major (BTM and 13 beta-thalassemia intermedia (BTI patients (6 males and 7 females; mean age: 19.6±3.5 years, range: 13-26 years were included in the study. The control group comprised 100 healthy blood donors. RESULTS: Neither heterozygous nor homozygous HFE gene C282Y mutation was detected in patients with BTM or BTI, or in control group. CONCLUSION: The C282Y mutation, which is supposed to be responsible for the majority of hereditary hemochromatosis, was not found to have a role in the development of hemochromatosis in beta-thalassemia patients and was not detected in a healthy Turkish population. However, research on larger cohorts of individuals is required in order to determine the exact prevalence of the HFE gene mutation in Turkish populations from diverse ethnic origins and whether it would have an impact on iron loading in thalassemic populations.

  12. Prevalence of hepatosplenomegaly in beta thalassemia minor subjects in Iran

    Energy Technology Data Exchange (ETDEWEB)

    Karimi, Mehran [Hemostasis and Thrombosis Unit, Hematology Research Center, school of Medicine, Shiraz University of medical sciences, Shiraz (Iran, Islamic Republic of)], E-mail: Karimim@sums.ac.ir; Bagheri, Mohammad Hadi [Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of); Tahmtan, Mehdi [Hemostasis and Thrombosis Unit, Hematology Research Center, school of Medicine, Shiraz University of medical sciences, Shiraz (Iran, Islamic Republic of); Shakibafard, Alireza [Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz (Iran, Islamic Republic of); Rashid, Murtaza [Hemostasis and Thrombosis Unit, Hematology Research Center, school of Medicine, Shiraz University of medical sciences, Shiraz (Iran, Islamic Republic of)

    2009-01-15

    Introduction: Thalassemia is the most common hereditary blood disorder in the world. Iran is located on the thalassemic belt and there is a high prevalence of the hepatosplenomegaly in beta thalassemia minor patients which is reported to be very variable. The goal of this research was to study the frequency of these signs in the cases with beta thalassemia minor patients in Iran. Materials and methods: Two hundred and fifty-nine cases that referred to center for pre-marriage tests were divided into two groups according to their MCV, MCH, and HbA2 (beta thalassemia minor cases and control groups). Liver and spleen sizes were determined by ultrasonographic method and the two groups were compared with each other. Results: Average spleen volumes in case and control groups were 163.48 {+-} 133.97 and 126.29 {+-} 53.98 mm{sup 3}, respectively. Average spleen lengths in case and control groups were 10.71 {+-} 1.52 and 10.60 {+-} 5.4 cm, respectively. Conclusion: In the regions with high frequency of beta thalassemia, in case of finding large spleen size in the ultrasonography, a probable harmless differential diagnosis will be beta thalassemia minor that is not indicative of any serious disease. Volumetric measurement of spleen is more reliable for detection of splenomegaly in these patients.

  13. A study of membrane protein defects and alpha hemoglobin chains of red blood cells in human beta thalassemia

    International Nuclear Information System (INIS)

    The soluble pool of alpha hemoglobin chains present in blood or bone marrow cells was measured with a new affinity method using a specific probe, beta A hemoglobin chain labeled with [3H]N-ethylmaleimide. This pool of soluble alpha chains was 0.067 ± 0.017% of hemoglobin in blood of normal adult, 0.11 ± 0.03% in heterozygous beta thalassemia and ranged from 0.26 to 1.30% in homozygous beta thalassemia intermedia. This elevated pool of soluble alpha chains observed in human beta thalassemia intermedia decreased 33-fold from a value of 10% of total hemoglobin in bone marrow cells to 0.3% in the most dense red blood cells. The amount of insoluble alpha chains was measured by using the polyacrylamide gel electrophoresis in urea and Triton X-100. In beta thalassemia intermedia the amount of insoluble alpha chains was correlated with the decreased spectrin content of red cell membrane and was associated with a decrease in ankyrin and with other abnormalities of the electrophoretic pattern of membrane proteins. The loss and topology of the reactive thiol groups of membrane proteins was determined by using [3H]N-ethylmaleimide added to membrane ghosts prior to urea and Triton X-100 electrophoresis. Spectrin and ankyrin were the major proteins with the most important decrease of thiol groups

  14. The effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients

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    Soleiman Mahjoub

    2007-12-01

    Full Text Available BACKGROUND: Thalassemia is the most common hereditary disease in the world. Thalassemic erythrocytes are exposed to higher oxidative stress and lipid peroxidation. The aim of this study was to investigate the effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients.
    METHODS: A prospective double-blind, placebo-controlled study of the effect of beta-carotene and vitamin E on lipid peroxidation in erythrocytes membranes was performed on 120 beta-thalassemia major patients in four groups. The patients were supplemented for 4 weeks as follows: group 1 with beta-carotene (13 mg/day, group 2 with vitamin E (550 mg/day, group 3 with beta-carotene plus vitamin E and group 4 with placebo. We prepared all capsules for 4 roups in the same shape and color. Measurements of serum beta-carotene and vitamin E were performed by high performance
    liquid chromatography. After preparation of ghost cells from blood specimens, malondialdehyde (MDA was determined as index of lipid peroxidation in erythrocytes membranes before and after treatment. RESULTS: The levels of serum beta-carotene and vitamin E were significantly lower and MDA concentrations in erythrocytes membranes were significantly higher in beta-thalassemia patients compared to controls (P<0.001. In groups that treated with vitamin supplements for 4-weeks, lipid peroxidation rates were significantly reduced after treatment (P<0.001, but in placebo group there was not significant difference (P>0.05.
    CONCLUSIONS: Our findings provide evidence that an oral treatment with beta-carotene and vitamin E can significantly reduce lipid peroxidation of erythrocytes membranes and could be useful in management of beta-thalassemia major patients. KEYWORDS: Beta-thalassemia major, beta-carotene, vitamin E, malondialdehyde, lipid peroxidation.

  15. Oxidative stress and antioxidant status in beta-thalassemia heterozygotes

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    Luciana de Souza Ondei

    2013-01-01

    Full Text Available Background: Several studies have evaluated the oxidant and antioxidant status of thalassemia patients but most focused mainly on the severe and intermediate states of the disease. Moreover, the oxidative status has not been evaluated for the different beta-thalassemia mutations. Objective: To evaluate lipid peroxidation and Trolox equivalent antioxidant capacity in relation to serum iron and ferritin in beta thalassemia resulting from two different mutations (CD39 and IVS-I-110 compared to individuals without beta-thalassemia. Methods: One hundred and thirty subjects were studied, including 49 who were heterozygous for beta-thalassemia and 81 controls. Blood samples were subjected to screening tests for hemoglobin. Allele-specific polymerase chain reaction was used to confirm mutations for beta-thalassemia, an analysis of thiobarbituric acid reactive species was used to determine lipid peroxidation, and Trolox equivalent antioxidant capacity evaluations were performed. The heterozygous beta-thalassemia group was also evaluated for serum iron and ferritin status. Results: Thiobarbituric acid reactive species (486.24 ± 119.64 ng/mL and Trolox equivalent antioxidant capacity values (2.23 ± 0.11 mM/L were higher in beta-thalassemia heterozygotes compared to controls (260.86 ± 92.40 ng/mL and 2.12 ± 0.10 mM/L, respectively; p-value < 0.01. Increased thiobarbituric acid reactive species values were observed in subjects with the CD39 mutation compared with those with the IVS-I-110 mutation (529.94 ± 115.60 ng/mL and 453.39 ± 121.10 ng/mL, respectively; p-value = 0.04. However, average Trolox equivalent antioxidant capacity values were similar for both mutations (2.20 ± 0.08 mM/L and 2.23 ± 0.12 mM/L, respectively; p-value = 0.39. There was no influence of serum iron and ferritin levels on thiobarbituric acid reactive species and Trolox equivalent antioxidant capacity values. Conclusion: This study shows an increase of oxidative stress and antioxidant capacity in beta-thalassemia heterozygotes, mainly in carriers of the CD39 mutation.

  16. A genetic score for the prediction of beta-thalassemia severity.

    Science.gov (United States)

    Danjou, Fabrice; Francavilla, Marcella; Anni, Franco; Satta, Stefania; Demartis, Franca-Rosa; Perseu, Lucia; Manca, Matteo; Sollaino, Maria Carla; Manunza, Laura; Mereu, Elisabetta; Marceddu, Giuseppe; Pissard, Serge; Joly, Philippe; Thuret, Isabelle; Origa, Raffaella; Borg, Joseph; Forni, Gian Luca; Piga, Antonio; Lai, Maria Eliana; Badens, Catherine; Moi, Paolo; Galanello, Renzo

    2015-04-01

    Clinical and hematologic characteristics of beta(?)-thalassemia are determined by several factors resulting in a wide spectrum of severity. Phenotype modulators are: HBB mutations, HBA defects and fetal hemoglobin production modulators (HBG2:g.-158C>T polymorphism, HBS1L-MYB intergenic region and the BCL11A). We characterized 54 genetic variants at these five loci robustly associated with the amelioration of beta-thalassemia phenotype, to build a predictive score of severity using a representative cohort of 890 ?-thalassemic patients. Using Cox proportional hazard analysis on a training set, we assessed the effect of these loci on the age at which patient started regular transfusions, built a Thalassemia Severity Score, and validated it on a testing set. Discriminatory power of the model was high (C-index=0.705; R(2)=0.343) and the validation conducted on the testing set confirmed its predictive accuracy with transfusion-free survival probability (P<0.001) and with transfusion dependency status (Area Under the Receiver Operating Characteristic Curve=0.774; P<0.001). Finally, an automatized on-line calculation of the score was made available at http://tss.unica.it. Besides the accurate assessment of genetic predictors effect, the present results could be helpful in the management of patients, both as a predictive score for screening and a standardized scale of severity to overcome the major-intermedia dichotomy and support clinical decisions. PMID:25480500

  17. Alpha hemoglobin stabilizing protein: Its causal relationship with the severity of beta thalassemia.

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    Sagar, Chandan S; Kumar, Rakesh; Sharma, Dharmesh C; Kishor, Purnima

    2015-08-01

    Thalassemia major is characterized by anemia, iron overload and cellular damage. The severity of symptoms correlates with the alpha/non-alpha globin imbalance and is proportional to the magnitude of alpha chain excess. Alpha hemoglobin stabilizing protein (AHSP), the erythroid specific alpha globin chaperone, stabilizes free alpha chains, and prevents the formation of reactive oxygen radicals. Though AHSP expression has been linked to the severity of beta thalassemia, its role as a probable genetic modifier of disease severity, has still not been unequivocally established. In the present study, the level of the chaperone has been seen to vary in regularly transfused beta thalassemia patients, being underexpressed in 64% of cases, upregulated in 16% and comparable to controls in 20% of the cases. This discrepancy may be attributed to the degree of DNA damage, % HbF, and the number of nucleated RBCs in the peripheral blood of these patients. Results reveal that a decrease in the free alpha chain pool, and hence the repertoire of unbound iron, due to elevated HbF and/or the presence of nucleated RBCs in the peripheral blood results in the upregulation of the AHSP gene. PMID:26142324

  18. Spinal cord compression due to extramedullary hematopoiesis in beta-thalassemia intermedia

    International Nuclear Information System (INIS)

    Background: Extramedullary hematopoiesis (EMH) occurs in many disorders, including thalassemias and other hemoglobinopathies, and commonly presents in the spleen and liver. We present a case of spinal cord compression in a patient with beta-thalassemia intermedia, and review the literature and available treatment options. Patient and Methods: A 35-year-old black female with beta-thalassemia intermedia presented with a 3-week history of back pain and lower extremity weakness. Neurologic examination was consistent with spinal cord compression, and gadolinium enhanced magnetic resonance imaging (MRI) confirmed this diagnosis. She was given intravenous steroids and radiotherapy was begun in 200 cGy fractions to a total dose of 2000 cGy. Results: At the completion of radiotherapy the patient was ambulatory with mild residual weakness. MRI scans 16 months later showed smaller, but persistent masses, and she remains asymptomatic 5 years from her diagnosis. Conclusion: Recognition of spinal cord EMH requires prompt physical examination and MRI for accurate diagnosis. EMH can be managed with radiation, surgery, transfusions, or a combination of these therapies. Radiation in conservative doses of (750-3500 cGy) is non-invasive, avoids the surgical risks of potentially severe hemorrhage and incomplete resection, and has a high complete remission rate in the majority of patients. Relapse rates are moderate (37.5%), but retreatment provides excellent chance for second remission

  19. X-ray scattering signatures of {beta}-thalassemia

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    Desouky, Omar S. [Radiation Physics Department, National Center for Radiation Research and Technology (NCRRT) (Egypt); Elshemey, Wael M. [Biophysics Department, Faculty of Science, Cairo University (Egypt)], E-mail: waelelshemey@yahoo.com; Selim, Nabila S. [Radiation Physics Department, National Center for Radiation Research and Technology (NCRRT) (Egypt)

    2009-08-11

    X-ray scattering from lyophilized proteins or protein-rich samples is characterized by the presence of two characteristic broad peaks at scattering angles equivalent to momentum transfer values of 0.27 and 0.6 nm{sup -1}, respectively. These peaks arise from the interference of coherently scattered photons. Once the conformation of a protein is changed, these two peaks reflect such change with considerable sensitivity. The present work examines the possibility of characterizing the most common cause of hemolytic anaemia in Egypt and many Mediterranean countries; {beta}-thalassemia, from its X-ray scattering profile. This disease emerges from a genetic defect causing reduced rate in the synthesis of one of the globin chains that make up hemoglobin. As a result, structurally abnormal hemoglobin molecules are formed. In order to detect such molecular disorder, hemoglobin samples of {beta}-thalassemia patients are collected, lyophilized and measured using a conventional X-ray diffractometer. Results show significant differences in the X-ray scattering profiles of most of the diseased samples compared to control. The shape of the first scattering peak at 0.27 nm{sup -1}, in addition to the relative intensity of the first to the second scattering peaks, provides the most reliable signs of abnormality in diseased samples. The results are interpreted and confirmed with the aid of Fourier Transform Infrared (FTIR) spectroscopy of normal and thalassemia samples.

  20. Diffuse Hepatic Calcifications in a Transfusion-Dependent Patient with Beta-Thalassemia: A Case Report

    Directory of Open Access Journals (Sweden)

    Forough Saki

    2013-09-01

    Full Text Available Hepatic calcification is usually associated with infectious, vascular, or neoplastic processes in the liver. We report the first case of beta-thalassemia major with isolated diffuse hepatic calcification in a 23 year old woman, who had been transfusion-dependent since the age of 6 months. She was referred to our center with a chief complaint of abdominal pain. Computed tomography scan of the abdomen revealed diffuse hepatic calcification in the right, left, and caudate lobes of the liver. Her medical history disclosed hypoparathyroidism as well as chronic hepatitis C virus infection, which was successfully treated but led to early micronodular cirrhosis on liver biopsy. Other studies done to search for the cause of hepatic calcification failed to reveal any abnormalities. We suspect that hypoparathyroidism caused liver calcification, and should be, therefore, considered in the differential diagnosis of hepatic calcification if other causative factors have been ruled out.

  1. Blood group genotyping facilitates transfusion of beta-thalassemia patients.

    Science.gov (United States)

    Castilho, Lilian; Rios, Maria; Pellegrino, Jordão; T O Saad, Sara; F Costa, Fernando

    2002-01-01

    We evaluated the usefulness of blood group genotyping as a supplement to hemagglutination to determine the red blood cell (RBC) antigen profile of polytransfused patients with beta-thalassemia. We selected 10 alloimmunized patients who were receiving antigen-matched RBCs based on phenotype, and had clinical evidence of delayed hemolytic transfusion reaction. DNA was prepared from blood samples and RH E/e, K1/K2, FY A/FY B, and JK A/JK B alleles were determined by PCR-RFLP. RH D/non-D was determined according to the PCR product size associated with the RHD gene sequence in intron 4 and exon 10/3'UTR. RH C/c was tested by multiplex PCR. The phenotypes and genotypes of nine of the 10 samples were discrepant. Five of the discrepancies occurred in the Rh system. One sample was phenotyped as Rhcc and genotyped as RH C/C, and two samples were phenotyped as RhCc and genotyped as RH C/C. Two other samples were phenotyped as RhEe and genotyped as RH e/e. Three samples had discrepancies in the Kidd system with phenotype Jk(a+b+) and were genotyped as homozygous for JK B. One sample had a discrepancy in the Duffy system: it was phenotyped as Fy(a+b-) and homozygous for FY B. Genotyping was very important in determining the true blood groups of many polytransfused patients with beta-thalassemia, and it assisted in the identification of suspected alloantibodies and the selection of antigen-negative RBCs for transfusion. PMID:12357449

  2. THERAPEUTIC VALUE OF COMBINED THERAPY WITH DEFERASIROX AND SILYMARIN ON IRON OVERLOAD IN CHILDREN WITH BETA THALASSEMIA

    Directory of Open Access Journals (Sweden)

    adel abd elhaleim hagag

    2013-11-01

    Full Text Available abstractBackground: Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia requiring life-long blood transfusion that cause iron overload. Silymarin plays a role as oral iron chelator and hepatoprotective agents in thalassemic patients.The aim of this work was to determine silymarin value as an iron chelator in thalassemic patients with iron overload.Patients and Methods: This study was conducted on 40 children with beta thalassemia major under follow-up at Hematology Unit, Pediatric Department, Tanta University Hospital having serum ferritin level more than 1000 ng/ml and was divided in two groups. Group IA: Received oral Deferasirox (Exjade and silymarin for 6 months. Group IB: Received oral Deferasirox (Exjade and placebo for 6 months and 20 healthy children serving as a control group in the period between April 2011 and August 2012 and was performed after approval from research ethical committee center in Tanta University Hospital and obtaining an informed written parental consent from all participants in this research. Results: Serum ferritin levels were markedly decreased in group IA cases compared with group IB (P= 0.001. Conclusion: From this study we concluded that, silymarin in combination with Exjade can be safely used in treatment of iron-loaded thalassemic patients as it showed good iron chelation with no sign of toxicity. Recommendations: Extensive multicenter studies in large number of patients with longer duration of follow up and more advanced methods of assessment of iron status is recommended to clarify the exact role of silymarin in reduction of iron over load in children with beta thalassemia.  

  3. THE DIAGNOSTIC VALUE OF PULSED WAVE TISSUE DOPPLER IMAGING IN ASYMPTOMATIC BETA- THALASSEMIA MAJOR CHILDREN AND YOUNG ADULTS ; RELATION TO CHEMICAL BIOMARKERS OF LEFT VENTRICULAR FUNCTION AND IRON OVERLOAD .

    Directory of Open Access Journals (Sweden)

    Seham Ragab

    2015-08-01

    Full Text Available Background: Cardiac iron toxicity is the leading cause of death among  ?-halassaemia major (TM  patients.  Once  heart failure becomes overt , it will be  difficult to reverse . Objectives: To investigate non overt cardiac dysfunctions  in TM patients using  pulsed wave Tissue Doppler  Imaging (TD I and its relation to the iron overload and brain natruritic peptide (BNP. Methods: Thorough  clinical , conventional echo and  pulsed  wave TDI  parameters were compared between  asymtomatic 25 ?-TM  patients  and 20 age and gender matched individuals. Serum ferritin and plasma BNP  levels were assayed by  ELISA .  Results: TM patients had significant higher mitral inflow early diastolic (E wave and  non significant other conventional echo  parameters. Pulsed wave TDI revealed systolic and diastolic dysfunctions in the form of significant higher  isovolumetric contraction time (ICT , ejection time ( E T and  isovolumetric relaxation time (IRT with significantly lower  mitral annulus  early diastolic velocity E` (12.07 ±2.06 vs 15.04±2.65 ,P= 0.003  in patients compared to  controls. Plasma BNP was higher in patients compared to the controls.  Plasma BNP and serum ferritin had significant correlation with each other and with pulsed wave conventional and TDI indices of systolic and diastolic functions.  Patients with E/E` ? 8 had  significant higher  serum ferritin  and plasma BNP levels compared to those with E/E` ratio < 8 without difference in Hb levels .Conclusion:  Pulsed wave TDI  is an  important diagnostic tool for latent cardiac dysfunction in iron loaded TM patients and is related to iron overload and BNP .    

  4. Marcadores eletrocardiográficos para detecção precoce de doença cardíaca em pacientes com talassemia beta maior / Electrocardiographic markers for the early detection of cardiac disease in patients with beta-thalassemia major

    Scientific Electronic Library Online (English)

    Kemal, Nisli; Yavuz, Taner; Oner, Naci; Salcioglu, Zafer; Karakas, Zeynep; Dindar, Aygun; Umrah, Aydogan; Rukiye, Eker; Turkan, Ertugrul.

    2010-04-01

    Full Text Available OBJETIVO: Analisar comparativamente a dispersão da onda P (DOP) em pacientes com talassemia beta maior (?-TM) e indivíduos saudáveis (controles) para a detecção precoce do risco de arritmias. MÉTODOS: Oitenta e uma crianças com ?-TM, com idades entre 4 e 19 anos, e 74 crianças saudáveis (grupo contr [...] ole) foram submetidas a exame eletrocardiográfico e ecocardiograma transtorácico de rotina para avaliação cardíaca. A DOP foi calculada como a diferença entre as durações máxima e mínima da onda P. RESULTADOS: Houve uma diferença estatisticamente significativa entre o grupo de estudo e o grupo controle no pico de velocidade do fluxo transmitral no início da diástole (E) e na razão E/fluxo transmitral tardio (A). A duração máxima da onda P e a DOP foram significativamente maiores nos pacientes com ?-TM do que nos indivíduos controles. CONCLUSÕES: O aumento da DOP em nossos pacientes com ?-TM pode estar relacionado à depressão na condução intra-atrial, devido à dilatação atrial, e ao aumento da atividade simpática. Estes pacientes devem ser acompanhados atentamente devido à possibilidade de ocorrência de arritmias com risco de vida. Abstract in english OBJECTIVE: To comparatively evaluate P-wave dispersion (PWD) in patients with ?-thalassemia major (TM) and healthy control subjects for the early prediction of arrhythmia risk. METHODS: Eighty-one children with ?-TM, aged 4-19 years, and 74 healthy children (control group) underwent routine electroc [...] ardiography and transthoracic echocardiography for cardiac evaluation. PWD was calculated as the difference between the maximum and the minimum P-wave duration. RESULTS: There was a statistically significant difference between study and control groups in peak early (E) mitral inflow velocity and E/late (A) velocity ratio. Maximum P-wave duration and PWD were found to be significantly higher in ?-TM patients than in control subjects. CONCLUSIONS: Increased PWD in our ?-TM patients might be related to depression of intra-atrial conduction due to atrial dilatation and increased sympathetic activity. These patients should be closely followed up for risk of life-threatening arrhythmias.

  5. Marcadores eletrocardiográficos para detecção precoce de doença cardíaca em pacientes com talassemia beta maior Electrocardiographic markers for the early detection of cardiac disease in patients with beta-thalassemia major

    Directory of Open Access Journals (Sweden)

    Kemal Nisli

    2010-04-01

    Full Text Available OBJETIVO: Analisar comparativamente a dispersão da onda P (DOP em pacientes com talassemia beta maior (?-TM e indivíduos saudáveis (controles para a detecção precoce do risco de arritmias. MÉTODOS: Oitenta e uma crianças com ?-TM, com idades entre 4 e 19 anos, e 74 crianças saudáveis (grupo controle foram submetidas a exame eletrocardiográfico e ecocardiograma transtorácico de rotina para avaliação cardíaca. A DOP foi calculada como a diferença entre as durações máxima e mínima da onda P. RESULTADOS: Houve uma diferença estatisticamente significativa entre o grupo de estudo e o grupo controle no pico de velocidade do fluxo transmitral no início da diástole (E e na razão E/fluxo transmitral tardio (A. A duração máxima da onda P e a DOP foram significativamente maiores nos pacientes com ?-TM do que nos indivíduos controles. CONCLUSÕES: O aumento da DOP em nossos pacientes com ?-TM pode estar relacionado à depressão na condução intra-atrial, devido à dilatação atrial, e ao aumento da atividade simpática. Estes pacientes devem ser acompanhados atentamente devido à possibilidade de ocorrência de arritmias com risco de vida.OBJECTIVE: To comparatively evaluate P-wave dispersion (PWD in patients with ?-thalassemia major (TM and healthy control subjects for the early prediction of arrhythmia risk. METHODS: Eighty-one children with ?-TM, aged 4-19 years, and 74 healthy children (control group underwent routine electrocardiography and transthoracic echocardiography for cardiac evaluation. PWD was calculated as the difference between the maximum and the minimum P-wave duration. RESULTS: There was a statistically significant difference between study and control groups in peak early (E mitral inflow velocity and E/late (A velocity ratio. Maximum P-wave duration and PWD were found to be significantly higher in ?-TM patients than in control subjects. CONCLUSIONS: Increased PWD in our ?-TM patients might be related to depression of intra-atrial conduction due to atrial dilatation and increased sympathetic activity. These patients should be closely followed up for risk of life-threatening arrhythmias.

  6. Genetic counseling for beta-thalassemia trait following health screening in a health maintenance organization: comparison of programmed and conventional counseling.

    OpenAIRE

    Fisher, L; Rowley, P T; Lipkin, M

    1981-01-01

    Providing adequate counseling of patients identified in genetic screening programs is a major responsibility and expense. Adults in a health maintenance organization, unselected for interest, were screened for beta-thalassemia trait as part of preventive health care. Counseling was provided by either a trained physician (conventional counseling) or by a videotape containing the same information followed by an opportunity to question a trained physician (programmed counseling). Immediately bef...

  7. Neurophysiologic and intellectual evaluation of beta-thalassemia patients.

    Science.gov (United States)

    Economou, Marina; Zafeiriou, Dimitrios I; Kontopoulos, Eleftherios; Gompakis, Nikos; Koussi, Aphroditi; Perifanis, Vasilios; Athanassiou-Metaxa, Miranda

    2006-01-01

    In order to detect involvement of the central and peripheral nervous system in beta-thalassemic patients, 32 children and young adults (mean age 14.5 +/- 6.4 years) participated in a systematic neurophysiologic and intellectual prospective study. All patients were in a regular transfusion program, receiving subcutaneous desferrioxamine chelation and maintaining a mean serum ferritin level of 2,101.56 +/- 986.32 ng/ml. Study patients underwent neurophysiologic evaluation consisting of brainstem auditory, visual and somatosensory evoked potential examination (BAEP, VEP, SEP) as well as motor and sensory nerve conduction velocity studies (MCV, SCV). Additionally, the verbal, performance and total IQ were assessed in patients under 16 years of age using the Weschler Intelligence Scale for Children (WISC-III). The incidence of abnormal BAEP, VEP, SEP and NCVs was 0, 3.12, 3.12 and 18.75%, respectively, findings comparative to or better than previously reported. On the contrary, the prevalence of abnormal total IQ score was considerably high (36.4%), not correlating, however, to any of the parameters assessed (age, sex, ferritin level, BAEP, VEP, SEP, NCV). Factors associated with chronic illness, rather than the disease per se, could play a potential role in the development of cognitive dysfunction in beta-thalassemia patients. PMID:15925466

  8. Valores de ferritina sérica em beta talassemia heterozigota / Serum ferritin levels in beta thalassemia carrier

    Scientific Electronic Library Online (English)

    Isabeth F., Estevão; Maria Cristina S., Souza; Antonio J., Manzato; Claudia R., Bonini-Domingos.

    Full Text Available [...] Abstract in english A low iron level, the commonest nutritional deficiency in the world, is a public health problem in developing countries. On the other hand, an excessive amount of iron is toxic, causing several organic dysfunctions, such as diabetes, cirrhosis, endocrinopathies and heart disease. Researchers have re [...] ported an association of iron overload with beta-thalassemia. The aim of this paper was to compare the serum ferritin levels of women with the beta-thalassemia trait. The results of serologic tests of 137 women of childbearing age were analyzed; 63 had the beta-thalassemia trait and 74 had Hb AA. In the beta-thalassemia carriers, the median ferritin value was 51.90 ng/mL and in the non-carriers 31.60 ng/mL (p = 0.0052). Levels of less than 20 and above 150 ng/mL were observed in 28% and 3% of the non-carriers and in 16% and 11% of the carriers, respectively. With these results it is possible to conclude that women in the reproductive age with the beta-thalassemia trait present higher ferritin levels in the northeastern region of São Paulo State. Further studies are necessary to clarify possible genetic and/or environment factors which interfere in iron absorption.

  9. [HbC/beta-thalassemia association. Eleven cases observed in Tunisia].

    Science.gov (United States)

    Fattoum, S; Guemira, F; Abdennebi, M; Ben Abdeladhim, A

    1993-01-01

    Eleven cases of simultaneous HbC hemoglobinopathy and beta-thalassemia were detected during a study of 11,200 subjects at high risk for inherited hemoglobin anomalies. In seven cases, main clinical manifestations were anemia and enlargement of the spleen, whereas the four other patients were apparently free of symptoms and were diagnosed during routine tests in family members of affected patients. Microcytosis and hypochromia were found in every case. Most of the patients were from the North-Western part of Tunisia. Blood transfusions were required in only one patient, who was an infant with HbC/beta + thalassemia. PMID:8442646

  10. beta-Thalassemia trait and hyperbilirubinemia in G-6-PD deficient newborn infants.

    Science.gov (United States)

    Meloni, T; Erre, S; Gallisai, D; Cutillo, S

    1980-08-01

    Hb A2 was determined in 50 subjects with erythrocyte G-6-PD deficiency who presented with hyperbilirubinemia in the neonatal period and in 100 non-hyperbilirubinemic G-6-PD deficient newborn infants, at the age of 12 months or more. Six subjects in the first group and 13 in the second were found to be carriers of the beta-thalassemia trait. Statistical analysis of the data did not show any significant difference between the two groups. It seems that the beta-thalassemia trait does not provide any protection against neonatal hyperbilirubinemia associated with G-6-PD deficiency. PMID:7439196

  11. Frequency of red cell allo- and autoimmunization in patients with transfusion-dependent beta thalassemia and affecting factors.

    Science.gov (United States)

    Koçyi?it, Cemil; Eliaç?k, Kay?; Kan?k, Ali; Atabay, Berna; Türker, Meral

    2014-01-01

    In this study, we aimed to determine the frequency of red cell allo- and autoimmunization and analyze the factors responsible for the development of antibodies in patients with transfusion-dependent thalassemia. This crosssectional study was conducted on 139 patients with thalassemia major and intermedia who received leukodepleted RBC transfusions on a regular basis. Patients with a positive antibody screen were further tested for antibody identification by a gel method. Red cell alloantibodies were found in 9 (6.4%) patients, and autoantibodies were found in 17 (12.2%) patients. The most common alloantibodies detected were those against Rh and Kell antigen systems. The alloantibody development rate was higher in thalassemia intermedia patients, in Rh(-) patients, in patients with an initial transfusion age >2 years and in patients with a transfusion interval >3 weeks (pcrossmatching with Kell and Rh subgroups may reduce alloimmunization in chronically transfused beta-thalassemia patients. PMID:26022583

  12. Prevalence of Beta-Thalassemia in premarital screening in Al-Hassa, Saudi Arabia

    International Nuclear Information System (INIS)

    The Al-Hassa area is one of the regions in Saudi Arabia where hemoglobinopathies are prevalent. The Saudi Ministry of Health designed a protocol for premarital testing after the royal decree in December 2003. The protocol was implemented in a February 2004 order. The aim of this study was to determine the prevalence of beta-thalassemia trait among subjects coming for premarital screening in the Al-Hassa area. From February 2004 to November 2004, healthy subjects coming to six marriages consultation centers in the Al-Hassa area underwent routine mandatory tests. Subjects were considered to have beta-thalassemia trait if they had a mean corpuscular volume (MCV), 80 fL and/or a mean corpuscular hemoglobin (MCH) 3.2%. Venous blood was taken into ETDA tube and the complete blood count and red blood cell indices were measured by a Coulter automated cell counter on the same day of hemoglobin collection. Electrophoresis was done on cellulose acetate. All Saudi participants (n=8918), including 4218 (47.3%) males and 4700 (52.7%) females were screened. The prevalence of beta-thalassemia trait with high hemoglobin A2 and microcytic hypochromic anemia was 3.4% (307/8918). In countries with a high prelevance of hemoglobinopathies, a premarital screening program is helpful for identification and prevention of high-risk marriages. With a 3.4% prevalence of beta-thalassemia trait in premarital couples, future comprehensive programs are needed to know the actual prevalence of beta-thalassemia in Al-Hassa. (author)

  13. Iron metabolism in heterozygotes for hemoglobin E (HbE), alpha-thalassemia1, or beta-thalassemia and in compound heterozygotes for HbE/ beta-thalassemia

    OpenAIRE

    Zimmermann, M. B.; Fucharoen, S; Winichagoon, P.; Sirankapracha, P.; Zeder, C.; Gowachirapant, S.; Judprasong, K.; Tanno, T.; Miller, J. L.; Hurrell, R F

    2008-01-01

    BACKGROUND: Despite large populations carrying traits for thalassemia in countries implementing universal iron fortification, there are few data on the absorption and utilization of iron in these persons. OBJECTIVE: We aimed to determine whether iron absorption or utilization (or both) in women heterozygous for beta-thalassemia, alpha-thalassemia 1, or hemoglobin E (HbE) differed from that in control subjects and compound HbE/beta-thalassemia heterozygotes. DESIGN: In Thai women (n = 103), re...

  14. Molecular basis of beta-thalassemia in the population of Tunisia.

    Science.gov (United States)

    Fattoum, Slaheddine; Messaoud, Taeib; Bibi, Amina

    2004-08-01

    The present study attempts to delineate the spectrum of beta-thalassemia (thal) mutations in Tunisia by studying a large population from different parts of the country. A total of 285 unrelated subjects, 190 of whom had beta-thal major, 72 with Hb S/beta-thal, one with Hb C/beta-thal, one with Hb O-Arab/beta-thal and 21 beta-thal carriers, were studied. The molecular defects were detected in 97.7% of the beta-thalassemic chromosomes (n=475). Nineteen different beta-thalassemic alleles were identified. Two mutations, namely codon 39 (C-->T) and IVS-I-110 (G-->A) accounted for 70.0% of the studied chromosomes, followed by IVS-I-1 (G-->A) (4.5%). Five other mutations, frameshift codon (FSC) 44 (-C), codon 30 (G-->C), IVS-I-2 (T-->G), IVS-II-745 (C-->G), and FSC 6 (-A), are not uncommon in this population, while the remaining 11 mutations, IVS-I-5 (G-->A), -30 (T-->A), codons 25/26 (+T), IVS-I-6 (T-->C), FSC 5 (-CT), IVS-II-848 (C-->A), FSC 8 (-AA), -87 (C-->G), IVS-I-5 (G-->C), IVS-II-1 (G-->A) and IVS-II-849 (A-->C) are quite rare; four of these have not been previously reported in the Tunisian population. Potential origin and spread of these mutations to Tunisia are also discussed. PMID:15481884

  15. [Association of Hbo Arab/beta-thalassemia discovered fortuitously in 2 brothers].

    Science.gov (United States)

    Mongalgi, M A; Debbabi, A; Guemira, F; Fattoum, S

    1992-04-01

    A four-year-old boy admitted for fever and a skin rash was diagnosed as having a rickettsial infection. Regenerative microcytic anemia and enlargement of the spleen were also found. Hemoglobin electrophoresis and a family study disclosed a combination of two heterozygous hemoglobinopathies, i.e., HbO Arab and beta-thalassemia. A male sibling had the same anomalies as the index patient and was free of symptoms. PMID:1616242

  16. Rare association between two genetic conditions: turner syndrome and beta thalassemia minor

    Directory of Open Access Journals (Sweden)

    Dorina STOICANESCU

    2009-11-01

    Full Text Available Rare disorders are defined as diseases, including those of genetic origin, which are life-threatening or chronically debilitating, which are of such low prevalence that special combined efforts are needed to address them. We present a case with a rare association between two genetic conditions: Turner phenotype and beta thalassemia minor. Turner syndrome is a chromosomal disorder that is characterized by the absence of all or part of a second sex chromosome in some or all cells. This condition occurs in 1 in 2,500 to 3,000 girls. The physical features include webbing of the neck, short stature, delayed growth of the skeleton, broad chest, cardivascular abnormalities and gonadal dysgenesis. Women with this disorder are usually infertile due to ovarian failure. The clinical diagnosis was confirmed by the cytogenetic and by FISH analysis, which revealed the presence of only one X chromosome. Treatment may include human growth hormone and estrogen replacement therapy. On the other hand, thalassemias are genetic conditions that result from imbalance in the normal coordinated synthesis of the globin subunits that make up the hemoglobin tetramer, leading to decreased and defective production of hemoglobin. Beta thalassemia syndromes are hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains. Beta thalassemia is inherited in an autosomal recessive manner. Thalassemia minor usually presents as an asymptomatic mild microcytic anemia, but our case also had splenomegaly and required splenectomy.

  17. Beta-thalassemia- institution based analysis of ethnic and geographic distribution, effect of consanguinity and safety of chorionic villus sampling as a diagnostic, tool for pre-natal diagnosis in selected patients

    International Nuclear Information System (INIS)

    To study the ethnic and geographic distribution of Beta-thalassemia amongst the patients included and to study the effect of consanguinity in promoting this disease. Also, to establish the safety of CVS when used as a pre-natal diagnostic tool in aiding the early diagnosis of Beta-thalassemia in selected patients. Study Design: Descriptive Study. Place and Duration of Study: PNS Shifa Karachi, from Jan 2008 to Dec 2008. Patients and Methods: A total of 223 women out of 240 that were referred from all over Sindh to PNS Shifa Hospital Karachi for susceptible gene mutations participated in the study. The standard procedure that was used in this study was trans-abdominal aspiration of chorionic villi through suction needle. The samples were then sent for further analysis to the Pathology Department at PNS Shifa Hospital Karachi. Results: In our study population Beta-thalassemia was most prevalent in Sindhi 107 (48%) followed by Punjabi 46 (21%), 27 (12%) Pathan, and 43 (19%) Balochi. Out of 223 women, 95 were of thalassemia trait, while 85 were of thalassemia major. Fifty five percent of thalassemia trait and 56% of thalassemia major fetus parents were first cousins. The rate of pregnancy loss after performing CVS was 2.0% with no complications reported. Conclusion: It is concluded that highest percentage of thalassemia is in first cousins and sindhi origin families are mostly affected. However CVS is a safe and effective tool for prenatal diagnosis and subsequent counselling in selected couples. (author)

  18. Haematological characterisation and molecular basis of asian Indian inversion deletions delta Beta thalassemia: a case report.

    Science.gov (United States)

    Khunger, Jitender Mohan; Gupta, Monika; Singh, Rekha; Kapoor, Rohit; Pandey, Hare Ram

    2014-09-01

    The hereditary persistence of fetal hemoglobin (HPFH) and delta beta thalassemia are heterogeneous disorders characterised by increased levels of fetal hemoglobin and high level of this Hb continues in adulthood. The distinction between these two conditions is not always possible with routine hematologic analysis and molecular characterisation of the defect is required. We encountered such a rare case of ? ? thalassemia in a 10-year-old male child who presented with features of thalassemia intermedia. Hemoglobin analysis showed 100% HbF while molecular analysis revealed Asian Indian inversion-deletion G?A?(? ?) zero thalassemia. PMID:25386442

  19. Homozygous delta-beta Thalassemia in a Child: a Rare Cause of Elevated Fetal Hemoglobin

    Directory of Open Access Journals (Sweden)

    Mittal SK MD

    2013-03-01

    Full Text Available AbstractBackgroundDelta beta (?? thalassemia is an unusual variant of thalassemia with elevated level of fetal hemoglobin (HbF. Homozygous patients of this disorder, unlike ?-thalassemia, show mild anemia. Only few cases of ??-thalassemia have been reported from India in the available indexed English literature.Case presentationA four-year old male child was evaluated for recent-onset jaundice. Hematological investigations showed mild anemia with microcytic hypochromic red cells. A comprehensive analysis of hemoglobin by high-performance liquid chromatography (HPLC showed complete absence of HbA and HbA2 with HbF constituting 100% of the hemoglobin. Hemoglobin analysis of both parents showed elevated level of HbF with normal HbA2. A final diagnosis of ??-thalassemia in the child with both parents being carriers was rendered. ConclusionDelta beta-thalassemia is an uncommon cause of markedly elevated fetal hemoglobin beyond fetal period. Clinical and haematological parameters should be evaluated to render an accurate diagnosis.

  20. [HbD Iran-beta-thalassemia association in a Tunisian family].

    Science.gov (United States)

    Guemira, F; Abbes, S; Ducrocq, R; Elion, J; Fattoum, S

    1992-06-01

    A nine-year-old boy from Béjà (North-Western Tunisia) was found to have both HbD Iran and beta-thalassemia. This patient presented with anemia and slight enlargement of the spleen and had a history of acute episodes of hemolysis. Structural studies on this hemoglobin variant used several miniaturized techniques, mainly carboxy-methyl-cellulose chromatography, reverse-phase high performance liquid chromatography and manual peptide sequencing using Chang's technique. The glutamic acid in position 22 on the beta chain was found to be replaced by a glutamine, establishing the diagnosis of HbD Iran. Concomitant presence of a thalassemia trait was suggested by the finding in the index patient of microcytosis, hypochromia and increased HbA2. The family study confirmed this patient's combined heterozygous anomalies, showing the D trait in the father and the beta thalassemia trait in the mother. The same combination was found in the index patient's sister who was, however, free of clinical symptoms. The explanation of this difference in clinical expression was provided by the ADN study which disclosed deletion of an alpha gene in the girl. The resulting alpha chain deficiency counterbalanced the beta chain deficiency. PMID:1497287

  1. Approaches to management of beta-thalassemia intermedia

    Directory of Open Access Journals (Sweden)

    Joseph E. Maakaron

    2013-03-01

    Full Text Available Thalassemia intermedia is a genetically diverse group of diseases that is the result of an imbalance in the production of the alpha and beta chains with ensuing chronic hemolysis, ineffective erythropoiesis, and iron overload.Resulting complications include bone changes, hypercoagulability, and end-organ damage due to iron overload. This decade has witnessed major breakthroughs in the management of thalassemia. In this article, we examine these novelties in therapy including iron chelation therapy, stem cell transplant, and gene therapy.Iron chelation therapy has been revolutionized with the advent of deferasirox, a once-daily oral iron chelator, that has been shown to be safe and efficacious.Gene therapy was also at the core of this revolution with the discovery of novel gene elements and viral vectors allowing for better control and improved outcomes.

  2. Survey of Hfe Gene C282Y Mutation in Turkish Beta-Thalassemia Patients and Healthy Population: A Preliminary Study

    OpenAIRE

    Ünal, Selma; Balta, Günay; Gümrük, Fatma

    2014-01-01

    Objective: This study was planned in order to determine the effect of C282Y mutation in development of secondary hemochromatosis in beta-thalassemia patients and to determine the prevalence and allele frequency of this mutation in a healthy control group.

  3. AB045. Molecular markers for disease severity in beta thalassemia/Hb E disease

    Science.gov (United States)

    Fucharoen, Suthat; Winichagoon, Pranee; Munkongdee, Thongperm; Sripichai, Orapan; Svasti, Saovaros

    2015-01-01

    Thalassemia is a hereditary disease affecting hemoglobin synthesis, characterized by microcytic hypochromic anemia. Homozygote or compound heterozygote patients usually manifested as thalassemia major which require regular treatment. There are five functional genes arranged in the order 5' ?-G?-A?-??-?-? 3' that are activated during development. Expression of the individual genes within the ?-globin cluster is controlled by the complex interactions between local regulatory sequence (promoter regions) within each gene and the ?-locus control region (?-LCR), located 6-18 kb upstream of the ?-globin gene. Beta thalassemia (?-thal) is a very heterogeneous disorder due to variations in inactivation mechanism of the ?-genes. Point mutations and small deletions or insertions in the nucleotide sequences are the main molecular defects responsible for most ?-thalassemia. In spite of seemingly identical genotypes, severity of ?-thal patients can vary greatly. This heterogeneity in the clinical severity may occur from the nature of ?-globin gene mutation, ?-thalassemia (?-thal) gene interaction and difference in the amount of Hb F production that is partly associated with a specific ?-globin haplotype. Co-inheritance of ?-thal may ameliorate the severity of ?-thal disease in those cases with mild ?-thal genotypes. However, many patients who are ?°/?+ thal or ?°-thal/Hb E do not have a detectable ?-thal haplotype but still have a mild clinical symptom suggests that there are other additional factors responsible for the mildness of the disease. Inheritance of a ?-thal chromosome with the Xmn I+ haplotype at the position -158 of the G?-globin gene was found to be associated with increased Hb F production and milder anemia in patients with thalassemia intermedia and Xmn I +/+ haplotype is necessary to produce a significant clinical effect. Homozygosity for the Xmn I + haplotype, +/+, was also found in the mild cases of ?-thal/Hb E. However, there is no severity difference among homozygous ?-thal patients with Xmn I +/+, ?/+ or ?/?. The GWAS study of the whole genome with more than 6000,000 SNPs of 1,100 ?-thal/Hb E patients with mild and severe diseases revealed SNPs in three independent genes that show significant association with the disease severity. The strongest SNPs associated with the disease severity located in three regions; the ?-globin gene cluster on chromosome 11, the HBS1L-MYB intergenic region on chromosome 6q23 and the BCL11A gene on chromosome 2p15. Further analysis of Hb F level showed that Hb F level was significantly higher in mild patients than moderate and severe patients (%Hb F; mild =42.6±11.5, moderate =35.7±11.1, severe =32.4±12.1; Plevel and frequency of Hb F-QTLs was studied in 520 cases. All individual SNPs on Hb F-QTLs are associated with Hb F (P value level. Our data indicated that several genetic loci act in concert to influence Hb F levels and disease severity of ?-thal/HbE patients. Understanding the genetic modifier in ?-thalassemia is important for the management of ?-thalassemia patients from PND to prognosis and decision for difficult treatment such as stem cell transplantation. Moreover, this may lead to future alternative treatment of ?-thalassemia patients as well.

  4. Peripheral expression of hepcidin gene in Egyptian ?-thalassemia major.

    Science.gov (United States)

    Aboul-Enein, Azza; El-Beshlawy, Amal; Hamdy, Mona; Shaheen, Iman; El-Saadany, Zainab; Samir, Ahmed; El-Samie, Hala Abd

    2015-06-15

    Iron overload is the major cause of morbidity and mortality in transfusion dependent ?-thalassemia major patients. There is a sophisticated balance of body iron metabolism of storage and transport which is regulated by several factors including the peptide hepcidin. Hepcidin is the main iron regulatory molecule; it is secreted mainly by the liver and other tissues including monocytes and lymphocytes. Expression of hepcidin in such cells is unclear and has been studied in few reports with controverted result. Peripheral expression of hepcidin was measured using quantitative real time PCR (qRT-PCR) in 50 ?-thalassemia major patients, in addition to 20 healthy volunteers as a control group. Hepcidin levels in ?-thalassemia major patients showed statistically significant decrease in comparison to the control group, and was correlated to cardiac iron stores (T2*). However, hepcidin level was not different among the patients according to the HCV status or whether splenectomized or not. In conclusion; peripheral expression of hepcidin, in iron overloaded ?-thalassemia major patients, is a reflection of hepatic expression. It can be used as a molecular predictor for the severity of cardiac iron overload and can be used as a future target for therapy in ?-thalassemia major patients. PMID:25816754

  5. A fast microelectronic array for screening and prenatal diagnosis of beta-thalassemia.

    Science.gov (United States)

    Foglieni, Barbara; Galbiati, Silvia; Ferrari, Maurizio; Cremonesi, Laura

    2008-01-01

    The electronic microchip is a recently developed technology for the fast and reliable detection of known single-nucleotide polymorphisms (SNPs) in the genome. The DNA fragment to be analyzed is directed electrophoretically into the chip, and then it is hybridized with fluorescent-tagged DNA probes specific for the mutant and wild-type sequences. The presence or absence of the mutation is detected by the fluorescence signal. Electronic stringency provides quality control for the hybridization process and ensures that any bound pairs of DNA are truly complementary; the microchip can be easily customized by the end user, allowing for assembly of specific probes onto the microchip to perform individualized analyses. Assays for 10 frequent mutations in the beta-globin gene causing beta-thalassemia and sickle cell anemia are presented that can be applied, in turn, to population screening or family study and prenatal diagnosis in single cases. PMID:18425480

  6. [The clinico-morphological characteristics of synovial membrane involvement in beta-thalassemia].

    Science.gov (United States)

    Nasonova, V A; Musaev, S K; Iakovleva, G I; Abasov, E Sh; Rustamov, R Sh

    1991-01-01

    Using data on optic and electron microscopy the authors give characteristics of lesions in the synovial membrane of the knee joints in 6 patients with an intermediary form of beta-thalassemia. Multiple reduplication of the basal membrane was noted in all the vessels, the width of the noncellular component of the vessels increased several times and its stratification was clearly seen. Deposits of iron oxide were revealed in biopsy samples of the synovial membrane of all the patients. Those deposits were in the form of microgranular intracellular inclusions in phagocytosing cells of the superficial stroma of villi but more often they were found in the cytoplasm of the vessel cells and pericytes. PMID:1812559

  7. Endocrine functioning in multitransfused prepubertal patients with homozygous beta-thalassemia.

    Science.gov (United States)

    Masala, A; Meloni, T; Gallisai, D; Alagna, S; Rovasio, P P; Rassu, S; Milia, A F

    1984-04-01

    Endocrine function was evaluated in 20 prepubertal patients with homozygous beta-thalassemia treated with frequent transfusions and long term iron chelation therapy. FSH, LH, PRL, and TSH secretion were evaluated by LRH and TRH testing and L-dopa and ACTH were used to assess GH and adrenocortical reserve. No statistically significant differences were found between FSH, LH, PRL, GH, and cortisol secretion in the patients and in normal subjects. There was a relatively high incidence (35%) of primary thyroid impairment since 1 patient had primary hypothyroidism and 6 others had evidence of subclinical hypothyroidism as manifested by increased TSH responses to TRH. However, no statistically significant correlations were found between either serum ferritin levels, total blood transfusions received, and thyroid function. PMID:6321534

  8. THE ROLE OF THE CAROTID DOPPLER EXAMINATION IN THE EVALUATION OF ATHEROSCLEROTIC CHANGES IN BETA THALASSEMIA PATIENTS

    Directory of Open Access Journals (Sweden)

    Gehan Lotfy Abdel Hakeem

    2015-02-01

    Full Text Available Iron over- load in patients with beta-thalassemia major lead to alterations in the arterial structures and in the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and fairly quick to perform and may identify children at increased risk of stroke who would otherwise be missed. Increased carotid artery intima media thickness (cIMT is a structural marker for early atherosclerosis and it correlates with the vascular risk factors and to the severity and extent of coronary artery disease. Objective: To evaluate the role of carotid Doppler examination and cIMT measurement as a predictive to atherosclerotic changes in  BTM children with iron overload.   Patients and Methods: Sixty two children with (BTM and 30 healthy normal controls of matched age and sex were included. Complete blood count, serum iron, ferritin, serum cholesterol and hemoglobin electrophoresis were performed as well as carotid Doppler ultrasonography to measure the (cIMT in both patients and controls. Results: By using carotid Doppler we found that cIMT of thalassemic patients was significantly increased compared to normal controls and there was significant positive correlation between CIMT and patient's age, weight, height, BMI, duration of illness, serum cholesterol, iron overload parameters as serum iron, serum ferritin, frequent blood transfusion, irregular use of iron chelating agents and in those who had splenectomy. Significant negative correlation was found between CIMT and hematocrit value but no significant correlation was found between CIMT and Hb level. Conclusion:  Carotid  Doppler is very useful method in measurement of cIMT that increased in thalassemic patients which  shows a strong relationship with features of iron overload. We recommend the routine use of Doppler measurement of cIMT in these patients to predict early atherosclerotic changes as well as in the follow-up to prevent progression of atherosclerosis. 

  9. Regional and ethnic distribution of beta thalassemia mutations and effect of consanguinity in patients referred for prenatal diagnosis

    International Nuclear Information System (INIS)

    To determine the regional and ethnic distribution of beta thalassemia mutation and the effect of consanguinity in patients referred for prenatal diagnosis of beta b-thalassemia and to target the high risk population for screening. A total of 499 couples were referred to Gentec Lab., Lahore, from all over Pakistan for prenatal diagnosis of b-thalassemia. After counseling, chorionic villus sampling was done between 10-16 weeks of gestation. DNA analysis was done by Amplification Refractory Mutation System (ARMS) for type of mutation in the Armed Forces Institute of Pathology, Rawalpindi. Ethnicity, race and consanguineous relationship of parents was determined.b-thalassemia was prevalent in Punjabis (60.7%) followed by Saraikees (25.5%). Castewise it was most frequent in Rajputs followed by Jatts, Arain, Sheikhs and Pathans. 56.7% of the couples were first cousins and 19.8% were relatives. The commonest mutations were Frameshift 8-9 (Fr8-9) 33.5%, Intervening Sequence 1-5 (IVS 1-5) 17.2%, Fr4142 - 8%, IVS 1-1 - 5.2%, Deletion 619 (Del 619) 4.2% and Codon 5 (Cd 5) - 4.2%. In samples sent for analysis, 53.1% turned out to be carriers (trait), 25.3% were diseased (thalassemia major) and 21.6% were normal. P-value of all results was less than 0.001. In this series, the highest frequency was found in Punjabi Rajputs. The commonest mutation was Fr 8-9. Most parents were first cousins. Premarital thalassemia carrier testing can effectively reduce the disease. (author)

  10. Egyptian wheat

    OpenAIRE

    Gowayed, Salah

    2009-01-01

    Wheat as the major cereal crop in Egypt is the core of the government's food security policy. But there are rapid losses of the genetic resources of the country as a result of ongoing modernization and development. Thus we compiled the largest possible number of Egyptian accessions preserved in the world gene banks. In the present study we collected nearly 1000 Egyptian wheat accessions. A part from the Triticum species of the Egyptian flora four species have been found, which were recorde...

  11. Screening and genetic counseling for beta-thalassemia trait in a population unselected for interest: comparison of three counseling methods.

    OpenAIRE

    Rowley, P T; Lipkin, M; Fisher, L

    1984-01-01

    We have assessed the effects of screening and genetic counseling for beta-thalassemia trait on knowledge, attitudes, and behavior in a prospective, controlled study of randomly selected adult members of a health maintenance organization. We report here that knowledge of manifestations and of inheritance of thalassemia, previously reported to be high immediately after counseling, were well maintained at 2 and 10 months following counseling. There was no detectable impairment of self-concept. M...

  12. Molecular comparison of delta beta-thalassemia and hereditary persistence of fetal hemoglobin DNAs: evidence of a regulatory area?

    Science.gov (United States)

    Ottolenghi, S; Giglioni, B; Taramelli, R; Comi, P; Mazza, U; Saglio, G; Camaschella, C; Izzo, P; Cao, A; Galanello, R; Gimferrer, E; Baiget, M; Gianni, A M

    1982-01-01

    The hematological phenotypes of several Mediterranean patients with delta beta-thalassemia and hereditary persistence of fetal hemoglobin have been characterized. Although clinical and hematological characteristics are essentially superimposable in all heterozygous delta beta-thalassemics, these patients show typical G gamma/A gamma ratios in their Hb F, ranging from approximately 0.07 in Sardinian to approximately 0.15 in Sicilian and approximately 0.35 in Spanish patients. A gamma Sardinian-(isoleucine-75 leads to threonine) is found in Spanish patients and accounts for all of the A gamma production in heterozygotes, indicating that persistent production of gamma chains occurs cis to the delta beta-thalassemia gene. The molecular heterogeneity of these conditions is demonstrated by restriction enzyme mapping of DNA; Sicilian and Calabrian patients show a deletion starting from the delta-globin intron and extending several kilobases 3' to the beta-globin gene; in Spanish patients the deletion starts approximately 2-3 kilobases 5' to the delta-globin gene and extends well beyond the beta-globin gene. Comparison of these deletions with previously described ones in Negro and in a new Southern Italian case of hereditary persistence of fetal hemoglobin suggests that the deletion of a region centered at a cluster of repetitive sequences approximately 3.5 kilobases 5' to the delta-globin gene may be critical for the persistent expression of high levels of gamma-globin in hereditary persistence of fetal hemoglobin compared to delta beta-thalassemia. The concept that the deletion or mutation of specific areas (rather than nonspecific changes brought about by large deletions in the globin cluster) is important in determining the persistent expression of gamma-globin genes is supported by the finding of a nondeletion type of delta beta-thalassemia in Sardinians. Images PMID:6179097

  13. Blood transfusion among thalassemia patients: A single Egyptian center experience

    Directory of Open Access Journals (Sweden)

    Lamis A Ragab

    2013-01-01

    Full Text Available Background: Although red cell transfusions are lifesavers for patients with thalassemia, they are responsible for a series of complications and expose the patients to a variety of risks. Material and Methods: This cross-sectional study included 464 Egyptian beta(? thalassemia major patients whose age ranged between 10 months and 31 years (mean 10.2 ± 6.6 years. All patients were subjected to thorough history taking with special emphasis on blood transfusions regarding rate of blood transfusion, type of received blood, and history of previous transfusion reactions in addition to type of chelation and compliance to iron chelation therapy and history of diabetes. Serum ferritin and pretransfusion hemoglobin assessment were done for all patients. Results: The mean pretransfusion hemoglobin level was 5.7 ± 1.16 g/dl. Allergic reactions were observed in 3.9% of the patients during the period of the study, while the history of previous allergic reaction was given by 72% of the patients. Deferiprone showed better compliance (58.6% than deferoxamine (26.3%. The prevalence of diabetes was 10.1% among the studied group. On comparing diabetics to nondiabetics, serum ferritin, transfusion intervals, and age were statistically higher among diabetics (P<0.001. Conclusion: Lower pretransfusion hemoglobin and high rate of prevalence of diabetes, in addition to better compliance to deferiprone than deferoxamine, were detected among the patients.

  14. Characterization of beta-thalassemia mutations in patients from the state of Rio Grande do Norte, Brazil

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    Zama Messala Luna da Silveira

    2011-01-01

    Full Text Available 35 unrelated individuals were studied for characterization as either heterozygous or homozygous for beta-thalassemia. Molecular analysis was done by PCR/RFLP to detect the mutations most commonly associated with beta-thalassemia (?0IVS-I-1, ?+IVS-I-6, and ?039. In the patients who showed none of these mutations, the beta-globin genes were sequenced. Of the 31 heterozygous patients, 13 (41.9% had the ?+IVS-I-6 mutation, 15 (48.4% the ?0IVS-I-1 mutation, 2 (6.5% the ?+IVS-I-110 mutation and 1 (3.2% the ?+IVS-I-5 mutation. IVS-I-6 was detected in the four homozygotes. The mutation in codon 39, often found in previous studies in Brazil, was not detected in the present case. This is the first study aiming at identifying mutations that determine beta-thalassemia in the state of Rio Grande do Norte.

  15. Characterization of beta-thalassemia mutations in patients from the state of Rio Grande do Norte, Brazil

    Scientific Electronic Library Online (English)

    Zama Messala Luna da, Silveira; Maria das Vitórias, Barbosa; Thales Allyrio Araújo de Medeiros, Fernandes; Elza Miyuki, Kimura; Fernando Ferreira, Costa; Maria de Fátima, Sonati; Ivanise Marina Moretti, Rebecchi; Tereza Maria Dantas de, Medeiros.

    Full Text Available 35 unrelated individuals were studied for characterization as either heterozygous or homozygous for beta-thalassemia. Molecular analysis was done by PCR/RFLP to detect the mutations most commonly associated with beta-thalassemia (?0IVS-I-1, ?+IVS-I-6, and ?039). In the patients who showed none of th [...] ese mutations, the beta-globin genes were sequenced. Of the 31 heterozygous patients, 13 (41.9%) had the ?+IVS-I-6 mutation, 15 (48.4%) the ?0IVS-I-1 mutation, 2 (6.5%) the ?+IVS-I-110 mutation and 1 (3.2%) the ?+IVS-I-5 mutation. IVS-I-6 was detected in the four homozygotes. The mutation in codon 39, often found in previous studies in Brazil, was not detected in the present case. This is the first study aiming at identifying mutations that determine beta-thalassemia in the state of Rio Grande do Norte.

  16. Prenatal diagnosis of sickle cell anemia and beta-thalassemia in southern Turkey.

    Science.gov (United States)

    Cürük, M Akif; Zeren, Filiz; Genç, Ahmet; Ozavci-Aygün, Sezen; Kilinç, Yurdanur; Aksoy, Kiymet

    2008-01-01

    Hemoglobinopathies are the most common genetic diseases in Turkey. The incidence of sickle cell trait is 10.0% and beta-thalassemia (beta-thal) trait is 3.7% in the Cukurova region of southern Turkey. Sickle cell anemia is prevalent in the Cukurova region, but beta-thal is seen all over the country. A prenatal diagnosis center was established in 1992 at Adana, Turkey, for the prevention of sickle cell anemia and beta-thal. Fifteen hundred and seventy-five fetuses were examined at the Cukurova University Hospital, Adana, Turkey. Three hundred and eighty-six fetuses were diagnosed as homozygous or compound heterozygous for sickle cell anemia and beta-thal. A total of 15 different beta-thal mutations were characterized in the parents. The incidence of the IVS-I-110 (G > A) mutation accounted for about 50.0% of the parents with beta-thal trait. Twenty-four different genotypes were observed in this study. A total of 286 fetuses were diagnosed with homozygous sickle cell disease, 57 fetuses were beta-thal homozygotes, 25 fetuses were compound heterozygotes with Hb S [beta6(A3)Glu-->Val, GAG > GTG], and 18 of the fetuses were double heterozygotes for beta-thal mutations. PMID:19065329

  17. Haplotypes linked to three rare beta-thalassemia mutations, originally reported in Tunisia.

    Science.gov (United States)

    Bibi, Amina; Messaoud, Taieb; Fattoum, Slaheddine

    2006-01-01

    The polymorphism of the beta-globin gene haplotypes and frameworks are useful in the determination of the unicentric and multicentric origin of a mutational event. In order to improve our knowledge of the chromosomal background of the beta-globin gene in three beta-thalassemia (thal) mutations originally reported in Tunisia, namely codons 25/26 (+T), codon 30 (G-->C) and IVS-I-2 (T-->G), we have investigated 13 unrelated individuals. There were five non transfusion-dependent patients homozygous for the IVS-I-2 (T-->G) mutation, five others were homozygous for the codon 30 (G-->C) mutation, one was a homozygote for the codons 25/26 (+T) insertion mutation and one patient was a compound heterozygote for the codon 39 (C-->T) and codon 25/26 (+T) mutations; the last patient had a betaS/codon 25/26 (+T) compound heterozygous genotype. Haplotype analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) based methods. The framework polymorphism was established by direct sequencing. beta-Globin gene analyses demonstrated that all IVS-I-2 (T-->G) cases were associated with haplotype IX; the codon 30 (G-->C) mutation was supported by haplotype I, while the codons 25/26 (+T) mutation was linked to haplotypes I and IX. PMID:16798642

  18. Metabolic and endocrinologic complications in beta-thalassemia major: a multicenter study in Tehran

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    Hashemi Reza

    2003-08-01

    Full Text Available Abstract Background The combination of transfusion and chelation therapy has dramatically extended the life expectancy of thalassemic patients. The main objective of this study is to determine the prevalence of prominent thalassemia complications. Methods Two hundred twenty patients entered the study. Physicians collected demographic and anthropometric data and the history of therapies as well as menstrual histories. Patients have been examined to determine their pubertal status. Serum levels of 25(OH D, calcium, phosphate, iPTH were measured. Thyroid function was assessed by T3, T4 and TSH. Zinc and copper in serum were determined by flame atomic absorption spectrophotometry. Bone mineral density (BMD measurements at lumbar and femoral regions have been done using dual x-ray absorptiometry. The dietary calcium, zinc and copper intakes were estimated by food-frequency questionnaires. Results Short stature was seen in 39.3% of our patients. Hypogonadism was seen in 22.9% of boys and 12.2% of girls. Hypoparathyroidism and primary hypothyroidism was present in 7.6% and 7.7% of the patients. About 13 % of patients had more than one endocrine complication with mean serum ferritin of 1678 ± 955 micrograms/lit. Prevalence of lumbar osteoporosis and osteopenia were 50.7% and 39.4%. Femoral osteoporosis and osteopenia were present in 10.8% and 36.9% of the patients. Lumbar BMD abnormalities were associated with duration of chelation therapy. Low serum zinc and copper was observed in 79.6% and 68% of the study population respectively. Serum zinc showed significant association with lumbar but not femoral BMD. In 37.2% of patients serum levels of 25(OH D below 23 nmol/l were detected. Conclusion High prevalence of complications among our thalassemics signifies the importance of more detailed studies along with therapeutic interventions.

  19. Peripheral Blood stem cell transplantation in children with Beta-thalassemia major

    International Nuclear Information System (INIS)

    Objective: To share the preliminary data on stem cell transplantation in Pakistan. Results: Engraftment was achieved in all patients except one who required a second dose of bone marrow graft on day +21. Median time to achieve absolute neutrophil count of > 0.5 x 10/sup 9/ /l was 9.0 days (range 8 - 31 days) and platelet count of > 20 x 10/sup 9/ /l was 14 days (12 - 35 days). Acute GVHD was seen in 3 patients, one patient had grade IV gut GVHD; another patient had grade III gut GVHD while third patient had grade II skin GVHD. Median hospital stay was 29 days. Six patients were well and transfusion independent 3 to 36 months post transplant. One episode of primary graft failure required a second dose of bone marrow harvest. Another episode of graft rejection received two doses of donor lymphocytes infusion. There were 4 deaths due to grade IV gut GVHD because of uncontrolled systemic Candida infection and one due to hepatic veno-occlusive (VOD) disease. Conclusion: Allogeneic peripheral blood stem cell transplantation can be safely and economically carried out in Pakistan. Although there had been 4 deaths during 36 months follow-up, with increasing understanding and experience the outcome is expected to improve. (author)

  20. A new valid formula in differentiating iron deficiency Anemia from beta-thalassemia trait

    International Nuclear Information System (INIS)

    Objective: To compare the validity of a new index (Hb X RDW X 100/ (RBC)/sup 2/ X MCHC) with twelve discriminating functions (DFs) to differentiate iron deficiency anemia (IDA) and beta-thalassemia trait (beta-TT). Methodology: A total of 823 patients (317 IDA and 506 beta-TT) aged 15 to 35 year old were enrolled in this study. The diagnostic sensitivity, specificity and other validity parameters were calculated to assess the diagnostic reliability of the novel index [Keikhaei index (KI)] vis-a-vis the other published DFs [Mentzer Index (MI), Green and King Index (G and KI), red cell distribution width index (RDWI), England and Fraser Index (E and FI), Bessman and Feinstein index (B and FI), Telmissani et al index (TI), Srivastava and Bevington index (S and BI), Shine and Lal index (S and LI), Ricerca et al index (RI), Ehsani et al index (EI), Sirdah et al index (SI), and Red Blood Cell Count(RBC)] were calculated in all patients. Results: All thirteen DFs did not have the sensitivity and specificity of 100%. The KI, RDWI, Gand KI and E and FI showed the most sensitivity and specificity for both IDA and TT; moreover, the lowest reliable indices belonged to B and FI, SandLI and RI. Conclusion: According to Youden's index (YI), DFs in the order of highest to lowest were KI > G and KI > RDWI > E and FI > RBC> M I> EI > TI > SI > S and BI > RI> SandLI >B and FI. (author)

  1. Better differential diagnosis of iron deficiency anemia from beta-thalassemia trait

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    Fakher Rahim

    2009-09-01

    Full Text Available Objective: Iron deficiency anemia (IDA and beta-thalassemia trait (ß-TT are the most common forms of microcytic anemia. This study was conducted to compare the validity of various discrimination indices in differentiating β-TT from IDA by calculating their sensitivity, specificity and Youden's index.Methods: Totally 323 subjects (173 children and 150 adults with microcytic anemia were involved in this study. We calculated 10 discrimination indices in all patients with IDA and β-TT. We divided the patients into two different groups as younger or older than 10 years. Results: None of the indices showed sensitivity and specificity of 100% in the patients older than 10 years, and in the patients younger than 10 years, only Shine & Lal index showed sensitivity close to 90% and specificity of 100%. The most accurate discriminative index for patients younger than 10 years was Shine & Lal and for those older than 10 years it was RDW index. According to Youden's index, Shine & Lal and RBC count showed the greatest diagnostic value in patients younger than 10 years and RDW and RBC count indices in those older than 10 years. Conclusion: None of the indices was completely sensitive and specific in differentiation between β-TT and IDA. Mean and median mean cell Hb density (MCHD were very close to normal values in both IDA and β-TT patients, but in the case of mean density of Hb/liter (MDHL, we found that the mean and median were significantly higher than normal values in β-TT and lower than normal values in IDA patients. In our study, Youden's index of RBC and Shine & Lal were the highest and most reliable indices in differentiating β-TT from IDA in the patients younger than 10 years. For patients older than 10 years, the most reliable discrimination indices were RBC and RDW.

  2. Glucose homeostasis in Egyptian children and adolescents with ?-Thalassemia major: Relationship to oxidative stress

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    Kotb Abbass Metwalley

    2014-01-01

    Full Text Available Background: Oxidative stress in children with ?-thalassemia may contribute to shortened life span of erythrocytes and endocrinal abnormalities. Aim: This study was aimed to evaluate glucose homeostasis in Egyptian children and adolescents with ?-thalassemia major and its relation to oxidative stress. Materials and Methods: Sixty children and adolescents with ?-thalassemia major were studied in comparison to 30 healthy age and sex-matched subjects. Detailed medical history, thorough clinical examination, and laboratory assessment of oral glucose tolerance test (OGTT, serum ferritin, alanine transferase (ALT, fasting insulin levels, plasma malondialdehyde (MDA as oxidant marker and serum total antioxidants capacity (TAC were performed. Patients were divided into two groups according to the presence of abnormal OGTT. Results: The prevalence of diabetes was 5% (3 of 60 and impaired glucose tolerance test (IGT was 8% (5 of 60. Fasting blood glucose, 2-hour post-load plasma glucose, serum ferritin, ALT, fasting insulin level, homeostatic model assessment for insulin resistance index (HOMA-IR and MDA levels were significantly elevated while TAC level was significantly decreased in thalassemic patients compared with healthy controls (P < 0.001 for each. The difference was more evident in patients with abnormal OGTT than those with normal oral glucose tolerance (P < 0.001 for each. We also observed that thalassemic patients not receiving or on irregular chelation therapy had significantly higher fasting, 2-h post-load plasma glucose, serum ferritin, ALT, fasting insulin, HOMA-IR, oxidative stress markers OSI and MDA levels and significantly lower TAC compared with either those on regular chelation or controls. HOMA-IR was positively correlated with age, serum ferritin, ALT, MDA, and negatively correlated with TAC. Conclusions: The development of abnormal glucose tolerance in Egyptian children and adolescents with ?--thalassemia is associated with alteration in oxidant-antioxidant status and increase in insulin resistance. Recommendation: 1- Glucose tolerance tests, HOMA-IR, and MDA should be an integral part of the long-term follow-up of children and adolescents with ?-thalassemia major. 2- Regular iron chelation and antioxidant therapy should be advised for thalassemic patients to improve glucose hemostasis.

  3. [The evolutionary effects of therapy on the skeletal lesions in beta-thalassemia].

    Science.gov (United States)

    Orzincolo, C; Castaldi, G; Bariani, L; Scutellari, P N

    1994-04-01

    Up to the mid-1960s, beta-thalassemia was treated with blood transfusions as frequent as needed to keep symptoms under control and to prevent transfusional hemosiderosis. In the following years, high transfusion regimens and iron chelation therapy with desferrioxamine were used. Because of these different treatment modalities, skeletal findings in thalassemia have markedly changed. In the past, thalassemic patients treated with a low transfusion regimen and without chelation therapy developed osteopenia--with widened medullary spaces, cortical thinning and trabecular atrophy--secondary to chronic expansion of red marrow, due to increased erythropoietin response to chronic anemic hypoxia. Typical radiographic patterns in the skull included widened diploic space, atrophic-especially outer--tables and, in some patients, the "hair-on-end" pattern. As for the face, obliteration of the paranasal sinuses and the typical "rodent facies" were observed. In the ribs, bulbous expansion of the posterior and anterior segments and the "rib within a rib" patterns were observed. As for the spine, coarse trabecular arrangement was seen. The "cobweb" pattern was seen in the pelvis and finally the lack of the normal concave outline was observed in the long bones. In the patients treated with high transfusion regimens and iron chelation therapy over the last 30 years, both skull anomalies and disfigurement are less frequent. The skull is almost normal, with the exception of osteopenia and thickened diploic space in the frontal bone only; the paranasal sinuses are usually not obliterated. The hands and rib are normal, just like long bones, pelvis, scapulae and vertebral bodies. Nevertheless, in some adequately treated patients new skeletal features have been recently observed in the long bones, which are similar to those occurring in rickets and/or scurvy, and in the vertebral bodies, resembling platyspondylia. These abnormal features might be caused by several factors--i.e., marrow expansion, transfusion regimens, direct/indirect effects of desferrioxamine, iron load, endocrine abnormalities, deficiency of some minerals and finally dysvitaminoses. Nevertheless, osteopenia remains the main negative factor of thalassemia. PMID:8190918

  4. [DNA diagnosis of beta-thalassemia. Study of restriction fragment length polymorphisms in families with affected children].

    Science.gov (United States)

    Solov'ev, G Ia; Luk'ianenko, A V; Tagiev, A F; Dadasheva, T S; Rustamov, R Sh

    1990-10-01

    A kit of DNA-probes directed at the cluster of human beta-globulin genes was used to study the incidence rate of 7 polymorphic restriction sites in beta-thalassemia patients and normal donors in the Azerbaijan SSR. Informative polymorphic sites Hind III were detected in GJ and AJ fetal globin genes, Hinc II in psi beta and Hinc III in 3' area of psi beta gene and Ava II in beta-globine gene differing in the incidence rate in the patients and donors. An analysis of haplotypes with respect to informative sites was made in two Azerbaijan families with an affected child. It has been found that the analysis with respect to one informative site is sufficient for prenatal diagnosis of the status of the following children. PMID:1706673

  5. Hemoglobina C em homozigose e interação com talassemia beta / Homozygous hemoglobin C and its interaction with beta thalassemia

    Scientific Electronic Library Online (English)

    Ivan L., Angulo; Sandra B. R., Picado.

    Full Text Available A hemoglobina C (Hb C) é originária do oeste da África e é detectada por migração lenta na eletroforese alcalina em acetato de celulose. Consiste na mutação do gene da globina beta no códon 6 (GAG-AAG), resultando na substituição do sexto aminoácido da cadeia beta da hemoglobina humana, o ácido glut [...] âmico, pelo aminoácido lisina. A cromatografia de alto desempenho (HPLC) separa completamente as frações C e A2, permitindo caracterizar a presença da interação com talassemia beta. Esta entidade (Hb CC, em homozigoze) é considerada benigna em relação à doença falciforme, já que a falcização não faz parte de sua fisiopatologia. A raridade do diagnóstico C homozigoto e C talassemia beta nos pacientes portadores de hemoglobinopatias nos alertou para a necessidade de se conhecer melhor e estudar aspectos clínicos e hematológicos dos casos dessa mutação em homozigose e na interação com a talassemia beta no ambulatório de anemias do Centro Regional de Hematologia e Hemoterapia de Ribeirão Preto, SP, Brasil. Abstract in english Hemoglobin C (Hb C) originated in the west of Africa and is detected by alkaline electrophoresis by slow migration in cellulose acetate. It consists of a mutation of the beta globin gene in codon 6 (GAG-AAG), resulting in a substitution of glutamic acid, the sixth amino acid of the beta string of th [...] e human hemoglobin, for lysine. High performance chromatography (HPLC) separates the C and A2 fractions completely, allowing the characterization of the presence of interactions with thalassemia beta. This entity (Hb CC) is considered benign in respect to sickle cell disease, as sickle cells are not part of its physiopathology. The rarity of the diagnosis of homozygous C and beta thalassemia in patients with hemoglobinopathies showed the necessity of studying clinical and hematologic aspects of the cases of this mutation in homozygosis carriers and the interaction with beta thalassemia in the anemias clinic of the Regional Blood Center in Ribeirao Preto, SP, Brazil.

  6. Perfil de beta talassemia heterozigota obtido a partir de análise data mining em banco de dados The profile of beta thalassemia obtained by data mining analysis in a database

    Directory of Open Access Journals (Sweden)

    Ana L. B. Domingos

    2010-02-01

    Full Text Available Variations in the phenotypic expression of heterozygous beta thalassemia reflect the formation of different populations. To better understand the profile of heterozygous beta-thalassemia of the Brazilian population, we aimed at establishing parameters to direct the diagnosis of carriers and calculate the frequency from information stored in an electronic database. Using a Data Mining tool, we evaluated information on 10,960 blood samples deposited in a relational database. Over the years, improved diagnostic technology has facilitated the elucidation of suspected beta thalassemia heterozygote cases with an average frequency of 3.5% of referred cases. We also found that the Brazilian beta thalassemia trait has classic increases of Hb A2 and Hb F (60%, mainly caused by mutations in beta zero thalassemia, especially in the southeast of the country.

  7. Comparative Effects of Three Iron Chelation Therapies on the Quality of Life of Greek Patients with Homozygous Transfusion-Dependent Beta-Thalassemia

    OpenAIRE

    Vasilis Goulas; Alexandra Kourakli-Symeonidis; Charalambos Camoutsis

    2012-01-01

    This prospective study assessed the quality of life of patients with homozygous transfusion-dependent beta-thalassemia in Greece receiving three different iron chelation treatments. Patients enrolled were receiving one of the following chelation therapies: deferoxamine (n = 21), deferasirox (n = 75), or deferoxamine in combination with deferiprone (n = 39). The three groups were compared in terms of their quality of life, satisfaction and adherence to treatment, control of their health, and s...

  8. Extraosseous radiotracer uptake on bone scan in beta-thalassemia: report of one case; Fixation extraosseuse du radiotraceur lors de la realisation d'une scintigraphie du squelette chez un patient atteint de beta-thalassemie: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Guezguez, M.; Nouira, M.; Sfar, R.; Chatti, K.; Ben Fradj, M.; Ben Ali, K.; Ajmi, S.; Essabbah, H. [CHU Sahloul, Service de Medecine Nucleaire, Sousse (Tunisia); Zrour, S. [EPS F. Bourguiba, Service de Rhumatologie, Monastir (Tunisia)

    2009-10-15

    Red blood cell transfusion, main therapeutic modality of beta-thalassemia, leads to iron overload which may perturb several metabolic ways. The aim of this paper is to illustrate the uptake abnormalities observed on bone scan of thalassaemic patients and to discuss mechanisms of extraosseous accumulation of the radiopharmaceutical in this pathology. We report a 16-year-old child suffering from beta-thalassemia major undergoing transfusion therapy. A bone scan was indicated to look for osseous infection. This study revealed a little skeletal uptake and abnormal liver, splenic and renal accumulation. A repeat bone scan, performed three weeks later showed a better skeletal uptake which enabled the discovery of focal abnormalities and made the diagnostic easier. The effect of iron overload on radiopharmaceuticals uptake in bone scan is known since 1975. Dissociation of {sup 99m}Tc from the carrier ligand due to the presence of iron excess seems the most plausible hypothesis. Free {sup 99m}Tc can be bound to other tissular substrates which can explain extraosseous uptake. The normally available pool for bone is reduced and then the skeletal uptake decreased. This report limits considerably the sensitivity of the bone scan. A well-led iron chelation and eventually the use of diuretic drug may guarantee a better quality of bone scan images. (authors)

  9. Factor V G1691A (Leiden is a major etiological factor in Egyptian Budd-Chiari syndrome patients

    Directory of Open Access Journals (Sweden)

    Tawhida Y. Abdel Ghaffar

    2011-12-01

    Full Text Available Objective: Budd-Chiari syndrome is a multifactorial disease in which several prothrombotic disorders may predispose patients to the development of thrombosis at this uncommon location (hepatic veins. The aim of this study was to determine the prevalence and characteristics of inherited thrombophilia in Egyptian Budd-Chiari syndrome patients.Materials and Methods: The study included 47 Budd-Chiari syndrome patients (20 children and 27 adults. Genotyping of Factor V G1691A (Leiden, prothrombin G20210A (PT, and methylenetetrahydrofolate reductase C677T were performed using real-time PCR and fluorescence melting curve detection analysis.Results: Factor V Leiden was observed in 29 patients (61.7%. It is the only factor that caused Budd-Chiari syndrome in 18 of the patients and in 5 of the patients with inferior vena cava involvement. Myeloproliferative disease was noted in 12 (25.5% patients, antiphospholipid syndrome in 5 (10.6%, and Behcet’s disease in 3 (6.4%. Interestingly, 3 of the children with Budd-Chiari syndrome had lipid storage disease.Conclusion: Factor V Leiden was a major etiological factor in Egyptian Budd-Chiari syndrome patients, which may have been related to the high frequency of this mutation in the study region. Factor V Leiden was also a strong thrombophilic factor and the leading cause of inferior vena cava thrombosis in these patients. Lipid storage disease should be included as a risk factor for Budd-Chiari syndrome.

  10. Assessment of the energy requirements and selected options facing major consumers within the Egyptian industrial and agricultural sectors. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-05-31

    The objectives of the energy assessment study of Egypt are to develop an understanding of the current status of the principal energy users in Egypt's industrial and agricultural sectors; to estimate the energy demand and efficiency for each selected subsector within these major sectors; to identify opportunities for fuel type changes, technology switches, or production pattern changes which might increase the efficiency with which Egypt's energy is used both now and in the future: and based on options identified, to forecast energy efficiencies for selected Egyptian subsectors for the years 1985 and 2000. Study results are presented for the iron and steel, aluminium, fertilizer, chemical, petrochemical, cement, and textile industries and automotive manufacturers. Study results for drainage, irrigation, and mechanization procedures in the agricultural sector and food processing sector are also presented. (MCW)

  11. The influence of the BCL11A polymorphism on the phenotype of patients with beta thalassemia could be affected by the beta globin locus control region and/or the Xmn1-HBG2 genotypic background.

    Science.gov (United States)

    Neishabury, Maryam; Zamani, Fahimeh; Keyhani, Elahe; Azarkeivan, Azita; Abedini, Seyedeh Sedigheh; Eslami, Masumeh Sadat; Kakroodi, Setareh Talebi; Vesiehsari, Mahjoobeh Jafari; Najmabadi, Hossein

    2013-08-01

    To study the influence of the ? globin locus control region (LCR) genotypic background on the phenotype modifying role of BCL11A polymorphisms, 100 cases of thalassemia, 48 homozygous for the A allele and 52 homozygous for the G allele at the 5'HS4-LCR palindromic polymorphic site were genotyped for two BCL11A single nucleotide polymorphisms (rs11886868 and rs766432) in the intronic region of this gene. The effect of these polymorphisms on HbF variation was also examined in 122 normal individuals. The 5'HS4-LCR had the most significant role in determining the phenotype of these thalassemia patients. BCL11A polymorphisms showed a significant role in determining the phenotype of patients homozygous for the G allele at 5'HS4-LCR. However, the majority of patients homozygous for the A allele at 5'HS4-LCR, showed a severe phenotype, regardless of the BCL11A genotype. These results, without undermining the strength of BCL11A as a silencer of the ? globin gene, suggest that the LCR background, by governing the state of BCL11A binding to this region, plays a more significant role in determining the thalassemia phenotype than the level of BCL11A protein expression, that might be influenced by single nucleotide polymorphisms in intronic regions of the BCL11A gene. Functional studies to confirm the interactions between BCL11A and LCR could be useful in designing pharmacogenetic strategies for the treatment of beta thalassemia major. PMID:23541515

  12. The molecular spectrum of beta-thalassemia and abnormal hemoglobins in the allochthonous and autochthonous dutch population.

    Science.gov (United States)

    Giordano, P C; Harteveld, C L; Heister, A J; Batelaan, D; van Delft, P; Plug, R; Losekoot, M; Bernini, L F

    1998-01-01

    The prevalence at birth of hemoglobin defects in the autochthonous North-European population is low. However, the long immigration and colonial history of the Netherlands has resulted in a group of about 1-2 million 'autochthonous' inhabitants, with Asian, South-European or African ancestors, in whom a moderate birth prevalence of globin gene mutations can be expected. Furthermore, at least 10% of the Dutch population consists of recent immigrants from different countries with high birth prevalence of hemoglobinopathies. Because of the endogamous partner choice, which is prevalent in this population, the risk for homozygous progeny remains elevated. At least 100,000 carriers of hemoglobinopathies of recent allochthonous origin are present in the Netherlands, and the number of homozygous children is rising. Prevention by prenatal diagnosis requires a suitable protocol and knowledge about the molecular defects present in the country. Therefore we have analyzed a large number of patients and carriers, both at the hematological and at the DNA level. Our survey revealed 47 different beta-thalassemia determinants, characterized on 223 independent chromosomes from individuals of different ethnic origins. As expected, the most prevalent mutations were largely represented. The cd39 (C-->T) mutation was found in 70% of the immigrants from Morocco, Sardinia and other Central-West-Mediterranean regions while the IVS-I-110 (G-->A) was prevalent in the East-Mediterranean populations. The IVS-I-5 (G-->C) mutation was found in 45% of the patients of Indonesian origin. We also registered 308 independent chromosomes with common structural defects (HbS, HbC, HbE, Hb Lepore, Hb Constant Spring and HbD Punjab) and 33 chromosomes with 19 different, less frequent, rare or very rare mutants. Seven structural mutants were described for the first time and published separately. Furthermore, 139 independent chromosomes with deletional and nondeletional alpha-thalassemia defects were characterized. PMID:15178968

  13. AB111. HBB: c. -78A>G/nt-28(A>G) associated with Cd 26(A-G) HbE, beta thalassemia variant causes thalassemia intermedia

    Science.gov (United States)

    Ly, Thi Thanh Ha; Ngo, Ngoc Diem; Ngo, Nhung Tuyet; Nguyen, Mai Thi Phuong; Nguyen, Huong Thi Mai; Duong, Truc Ba

    2015-01-01

    ?-thalassemia is the most common single gene disorder worldwide and in Vietnam. In the present study we report in members of a family from North Vietnam, the mother compound heterozygous thalassemia intermedia presenting mutation of hemoglobin HBB: c. -78A>G/nt-28(A>G) with Cd 26(A-G) HbE. The father, heterozygous for Cd71/72(+A), ?+ beta thalassemia. To our knowledge, this is the first report of -28(A>G) in trans with beta thalassemia variant Cd 26(A-G) HbE leading to beta thalassemia intermedia. Our data highlight the necessity of deep molecular characterization of subjects presenting normal HbA2 level associated with abnormal red cell indices. It’s necessary for accurate diagnosis and improved genetic counseling.

  14. Posttranscriptional defects in beta-globin messenger RNA metabolism in beta-thalassemia: abnormal accumulation of beta-messenger RNA precursor sequences.

    OpenAIRE

    Benz, E. J.; Scarpa, A L; Tonkonow, B L; Pearson, H A; Ritchey, A K

    1981-01-01

    The production of beta-globin messenger RNA (mRNA) in beta-thalassemic erythroblasts was studied during pulse-chase incubations with [3H]uridine. Globin [3H]mRNA was quantitated by molecular hybridization to recombinant DNA probes complementary to globin mRNA and mRNA precursor sequences. Each of six patients with beta +-thalassemia produced normal amounts of globin alpha and beta [3H]mRNA during a 20-min pulse incubation, but the beta/alpha [3H]mRNA ratio declined to steady-state levels duri...

  15. Growth pattern in children with beta-thalassemia major and its relation with serum ferritin, IGF1 and IGFBP3

    Directory of Open Access Journals (Sweden)

    Mona Ramadan Nasr

    2012-06-01

    Full Text Available Objectives: Growth impairment in children with Betathalassemiamajor (BTM has several possible etiologiesincluding excess iron overload and endocrinologic abnormalities.We aimed to assess growth in children withBTM and its relation with serum ferritin, thyroid hormones,IGF1 and IGFBP3.Materials and methods: Thirty-three children with BTMand 30 healthy children (control group matched in age,sex and height were subjected to full clinical history andexamination, including anthropometric measurements.Fasting blood samples from both groups were taken forcomplete blood counts, fasting blood sugar, liver functiontests, serum ferritin, thyroid profiles, IGF1 and IGFBP3.Bone ages for both groups were determined radiologically.Results: A total of 57.6% of BTM group had retardedlinear growth and 45.5% of them were with delayed puberty.There was statistical significant decrease in upper/lower segment (U/L ratio in the BTM group comparedto the control group (p=0.035. No apparent hypothyroidismwas found in the thalassemia group, but significantdecreases were found in both IGF1 and IGFBP3 levels ofthe thalassemia group compared with the control group(p=0.022 and p=0.037, respectively. There was a significantcorrelation between T4 and U/L ratio (p<0.05; IGF1was significantly correlated with height, duration of transfusionsand duration of chelation (p<0.05. No significantcorrelation was found between serum ferritin and othervariables of the patients.Conclusions: Growth retardation in children with BTM isevident despite regular transfusions and chelation therapy,especially in children with older age and the cause ismainly in growth hormone-IGF1 and IGFBP3 axis. J ClinExp Invest 2012; 3(2: 157-163

  16. Insulin-like growth factor-1 levels in children with Beta-thalassemia minor

    Directory of Open Access Journals (Sweden)

    Mehran Karimi

    2008-09-01

    Full Text Available Objective: Growth retardation in children with b-thalassemia major is multifactorial. Some etiologies described for this condition are hemochromatosis, disturbed growth hormone (GH / insulin growth factor-1 (IGF-1 axis, undernutrition and hypermetabolism. It has also been proven that growth retardation is present in b-thalassemia major children despite regular transfusion and chelation. Our aim was to evaluate the level of IGF-1 in b-thalassemia minor subjects and compare it with that in healthy children. Material and Methods: Fifty children aged 6 months to 15 years with b-thalassemia minor (32 males, 18 females and 50 age- and sex-matched normal healthy children were selected. Medical history was taken and complete physical examination was done in each case; IGF-1 level was checked in all cases. This study was done in Shiraz, southern Iran, during 2005.Results: IGF-1 levels were significantly lower in b-thalassemia minor children than normal children (P = 0.015. This result demonstrates that some etiologies of growth failure in b-thalassemia major other than those described to date can exist, which may be shared with b-thalassemia minor in feature or may be transformed by genes that are either expressed or not.Conclusion: We conclude that in addition to that observed in b-thalassemia major, IGF-1 level is also decreased in b-thalassemia minor, and these two may have similar etiologies.

  17. AB045. Molecular markers for disease severity in beta thalassemia/Hb E disease

    OpenAIRE

    Fucharoen, Suthat; Winichagoon, Pranee; Munkongdee, Thongperm; Sripichai, Orapan; Svasti, Saovaros

    2015-01-01

    Thalassemia is a hereditary disease affecting hemoglobin synthesis, characterized by microcytic hypochromic anemia. Homozygote or compound heterozygote patients usually manifested as thalassemia major which require regular treatment. There are five functional genes arranged in the order 5' ?-G?-A?-??-?-? 3' that are activated during development. Expression of the individual genes within the ?-globin cluster is controlled by the complex interactions between local regulatory sequence (promoter ...

  18. Hypogonadotropic hypogonadism in severe beta-thalassemia: effect of chelation and pulsatile gonadotropin-releasing hormone therapy.

    Science.gov (United States)

    Wang, C; Tso, S C; Todd, D

    1989-03-01

    We studied pituitary-gonadal function in 11 male and 5 female patients, aged 12-30 yr, with severe beta-thalassemia and chronic iron overload. All had normal basal serum cortisol, T4, and PRL concentrations and normal serum cortisol and GH responses to insulin-induced hypoglycemia and TSH responses to TRH. Of the 11 male patients (all over 17 yr of age), only 3 attained full pubertal development and 4 had subnormal serum LH and FSH responses to GnRH. As a group, their mean basal serum testosterone (T) level was low [11.7 +/- 4.9 (+/- SE) nmol/L; normal, 10-40 nmol/L], and 9 of the 11 male patients responded to hCG with a rise in serum T. Two of the 3 female patients over 17 yr of age were prepubertal with undetectable serum estradiol (E2) levels and absent serum LH and FSH responses to GnRH; the other female patient had regular menstrual cycles and normal serum E2 levels and LH and FSH responses to GnRH. Six of the prepubertal patients (4 males and 2 females, aged 17-30 yr) were studied serially for 3 yr after the start of chelation therapy. Despite a fall of median serum ferritin from 11,910 to 1,303 pmol/L, there was no progression of puberty, and their basal and GnRH-stimulated serum LH and FSH and serum T or E2 levels did not change. Three of these patients (1 male and 2 female) then received pulsatile sc GnRH therapy in addition to chelation therapy for 6 months with no improvement. We conclude that chronic iron overload in patients with severe thalassemia leads to variable degrees of hypogonadotropic hypogonadism, which do not respond to chelation therapy given late in the course of the disease. The hypogonadism in most patients was due to pituitary hyporesponsiveness to GnRH. PMID:2493034

  19. Xmni polymorphism and disease severity in patients with beta thalassemia from northern Pakistan

    International Nuclear Information System (INIS)

    Thalassemia is a heterogeneous disorder and several genetic factors influence the severity of thalassemia. An accurate and early diagnosis of a mild thalassemia genotype helps to avoid unnecessary transfusion and its complications. The aim of this study is to identify the association between XmnI polymorphism and disease severity in patients with ?-thalassemia from northern Pakistan. Methods: The cross sectional study was conducted at the Department of Haematology, Armed Forces Institute of Pathology (AFIP) Rawalpindi, from September 2006 to June 2009. A total of 90 subjects including 30 with thalassemia major, 30 with thalassemia intermedia and 30 normal individuals were studied. DNA from each subject was tested for 15 ?-thalassemia mutations and the presence of XmnI polymorphism using Amplification Refractory Mutation System and Restriction Fragment Length Polymorphism respectively. Results: One normal and one thalassemia major subject were found to be positive for homozygous and heterozygous XmnI polymorphism respectively. Among the thalassemia intermedia group, XmnI polymorphism was found in 12/30 patients, of whom 10 were homozygous and 2 were heterozygous for it. Conclusion: XmnI polymorphism is an important genotypic factor in Pakistani population for making a prospective diagnosis of thalassemia intermedia and predicting the severity of the disease. (author)

  20. The molecular basis of beta-thalassemia intermedia in southern China: genotypic heterogeneity and phenotypic diversity

    Directory of Open Access Journals (Sweden)

    Sun Manna

    2010-02-01

    Full Text Available Abstract Background The clinical syndrome of thalassemia intermedia (TI results from the ?-globin genotypes in combination with factors to produce fetal haemoglobin (HbF and/or co-inheritance of ?-thalassemia. However, very little is currently known of the molecular basis of Chinese TI patients. Methods We systematically analyzed and characterized ?-globin genotypes, ?-thalassemia determinants, and known primary genetic modifiers linked to the production of HbF and the aggravation of ?/? imbalance in 117 Chinese TI patients. Genotype-phenotype correlations were analyzed based on retrospective clinical observations. Results A total of 117 TI patients were divided into two major groups, namely heterozygous ?-thalassemia (n = 20 in which 14 were characterized as having a mild TI with the Hb levels of 68-95 g/L except for five co-inherited ???anti-3.7 triplication and one carried a dominant mutation; and ?-thalassemia homozygotes or compound heterozygotes for ?-thalassemia and other ?-globin defects in which the ?+-thalassemia mutation was the most common (49/97, hemoglobin E (HbE variants was second (27/97, and deletional hereditary persistence of fetal hemoglobin (HPFH or ??-thalassemia was third (11/97. Two novel mutations, Term CD+32(A?C and Cap+39(C?T, have been detected. Conclusions Chinese TI patients showed considerable heterogeneity, both phenotypically and genotypically. The clinical outcomes of our TI patients were mostly explained by the genotypes linked to the ?- and ?-globin gene cluster. However, for a group of 14 patients (13 ?0/?N and 1 ?+/?N with known heterozygous mutations of ?-thalassemia and three with homozygous ?-thalassemia (?0/?0, the existence of other causative genetic determinants is remaining to be molecularly defined.

  1. STUDY OF SERUM HAPTOGLOBIN LEVEL AND ITS RELATION TO ERYTHROPOIETIC ACTIVITY IN BETA THALASSEMIA CHILDREN .

    Directory of Open Access Journals (Sweden)

    Seham Ragab

    2015-02-01

    Full Text Available Background  :Serum haptoglobin (Hp is a reliable marker for hemolysis regardless the inflammatory state.  Objective: We investigated the possible relation between Hp depletion and hemolysis severity, hepatitis C virus (HCV infection and iron load in β-thalassemia children. Methods: Twenty  two β-thalassemia major (TM ,20 β-thalassemia  intermedia (TI children with 20 age and sex matched healthy controls were involved. Pre-transfusion hemoglobin level was considered . Serum ferritin , Hp  and transferrin receptor  levels (sTfR  (by ELISA , alanine aminotransferase (ALT and  aspartate aminotransferase (AST  (by colorimetric method were assayed. Markers of hepatitis C virus  (HCV  were done by PCR. Results:  The mean Hp levels among the studied groups were as follows; 8.02 ± 0.93 (mg/dl , 8.6 ±0.72 (mg/dl  and 122  ± 18.5(mg/dl   for TM ,TI and the controls respectively . Both patient groups had significantly lower Hp level compared to the controls (P<0.0001  with significant lower level in TM compared to TI  children ( P= 0.034  .Significant inverse correlations were  found between serum Hp and sTfR levels in thalassemia children combined and in each group (TM and TI as well as among HCV infected children. STfR   was the only significant independent predictor for  serum Hp level (t= -5.585 , P<0.0001 . Among  HCV infected patients , no significant correlation was found between serum Hp and serum transaminases  .Conclusion:  Serum Hp depletion in thalassemia had significant relation to disease severity and correlated   well with their erythropoietic activity, as assessed by the measurement of  sTfR without significant relation  HCV infection . Large sample  multicenter studies are  recommended.  

  2. Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults

    OpenAIRE

    Thein, SL; Menzel, S.; Peng, X.; Best, S; Jiang, J.; Close, J; Silver, N; Gerovasilli, A; Ping, C; Yamaguchi, M; Wahlberg, K; Ulug, P; Spector, TD; GARNER, C; Matsuda, F.

    2007-01-01

    Individual variation in fetal hemoglobin (HbF, alpha(2)gamma(2)) response underlies the remarkable diversity in phenotypic severity of sickle cell disease and beta thalassemia. HbF levels and HbF-associated quantitative traits (e.g., F cell levels) are highly heritable. We have previously mapped a major quantitative trait locus (QTL) controlling F cell levels in an extended Asian-Indian kindred with beta thalassemia to a 1.5-Mb interval on chromosome 6q23, but the causative gene(s) are not kn...

  3. Egyptian gas for sale

    Energy Technology Data Exchange (ETDEWEB)

    Buckman, D.

    1995-07-01

    Israel, Jordan, Palestine, the Lebanon, Turkey and Italy all have at least one factor in common: they`re potential customers for Egyptian gas. Once under-used, this major resource is now set to become a valuable export commodity by the turn of the century. (author)

  4. Integrative proteome and transcriptome analysis of extramedullary erythropoiesis and its reversal by transferrin treatment in a mouse model of beta-thalassemia.

    Science.gov (United States)

    Vallelian, Florence; Gelderman-Fuhrmann, Monique P; Schaer, Christian A; Puglia, Michele; Opitz, Lennart; Baek, Jin Hyen; Vostal, Jaroslav; Buehler, Paul W; Schaer, Dominik J

    2015-02-01

    Beta-thalassemia results from mutations of the ?-hemoglobin (Hbb) gene and reduced functional Hbb synthesis. Excess ?-Hb causes globin chain aggregation, oxidation, cytoskeletal damage, and increased red blood cell clearance. These events result in anemia, altered iron homeostasis, and expansion of extramedullary erythropoiesis. Serum transferrin (Tf) is suggested to be an important regulator of erythropoiesis in murine models of thalassemia. The present study was conducted to establish a quantitative proteomic and transcriptomic analysis of transferrin-modulated extramedullary erythropoiesis in the spleen of wild type and thalassemic Hbb(th3/+) mice. Our LC-MS/MS protein analysis and mRNA sequencing data provide quantitative expression estimates of 1590 proteins and 24,581 transcripts of the murine spleen and characterize key processes of erythropoiesis and RBC homeostasis such as the whole heme synthesis pathway as well as critical components of the red blood cell antioxidant systems and the proliferative cell cycling pathway. The data confirm that Tf treatment of nontransfused Hbb(th3/+) mice induces a systematic correction of these processes at a molecular level. Tf treatment of Hbb(th3/+) mice for 60 days leads to a complete molecular restoration of the normal murine spleen phenotype. These findings support further investigation of plasma-derived Tf as a treatment for thalassemia. PMID:25566950

  5. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia.

    Science.gov (United States)

    Cappellini, Maria Domenica; Cohen, Alan; Piga, Antonio; Bejaoui, Mohamed; Perrotta, Silverio; Agaoglu, Leyla; Aydinok, Yesim; Kattamis, Antonis; Kilinc, Yurdanur; Porter, John; Capra, Marcello; Galanello, Renzo; Fattoum, Slaheddine; Drelichman, Guillermo; Magnano, Carmelo; Verissimo, Monica; Athanassiou-Metaxa, Miranda; Giardina, Patricia; Kourakli-Symeonidis, Alexandra; Janka-Schaub, Gritta; Coates, Thomas; Vermylen, Christiane; Olivieri, Nancy; Thuret, Isabelle; Opitz, Herbert; Ressayre-Djaffer, Catherine; Marks, Peter; Alberti, Daniele

    2006-05-01

    Deferasirox (ICL670) is a once-daily oral iron chelator developed for the treatment of chronic iron overload from blood transfusions. A comparative phase 3 trial was conducted to demonstrate the efficacy of deferasirox in regularly transfused patients with beta-thalassemia aged 2 years or older. Patients were randomized and received treatment with deferasirox (n = 296) or deferoxamine (n = 290), with dosing of each according to baseline liver iron concentration (LIC). The primary endpoint was maintenance or reduction of LIC; secondary endpoints included safety and tolerability, change in serum ferritin level, and net body iron balance. In both arms, patients with LIC values of 7 mg Fe/g dry weight (dw) or higher had significant and similar dose-dependent reductions in LIC and serum ferritin, and effects on net body iron balance. However, the primary endpoint was not met in the overall population, possibly due to the fact that proportionally lower doses of deferasirox relative to deferoxamine were administered to patients with LIC values less than 7 mg Fe/g dw. The most common adverse events included rash, gastrointestinal disturbances, and mild nonprogressive increases in serum creatinine. No agranulocytosis, arthropathy, or growth failure was associated with deferasirox administration. Deferasirox is a promising once-daily oral therapy for the treatment of transfusional iron overload. PMID:16352812

  6. Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening

    Directory of Open Access Journals (Sweden)

    Tiwari Aseem

    2009-01-01

    Full Text Available Background: The prevalence of microcytosis in donors and Iron Deficiency Anemia (IDA and Beta-Thalassemia trait (BTT in microcytic and non-microcytic donors has not been studied in India. The present study aims at finding the same. Materials and Methods: Initially 925 donor samples were evaluated on cell-counter. Of these, 50 were found to be microcytic. These were subjected to Ferritin and HbA2 determination. Subsequently, an additional 51, age-and-sex matched non-microcytic donor samples were selected to serve as controls. These were subjected to the same tests. Results: The prevalence of microcytosis was 5.4% (50/925. Among the microcytic donors, 52% were IDA, 36% BTT, 8% both, and 4% none. In case of non-microcytic donors 29.4% were IDA, 3.9% BTT, and 66.7% none. Conclusions: The study revealed a high prevalence of IDA and BTT in blood donors and a higher probability of finding these in the microcytic samples. This prompted authors to suggest an algorithm for screening of blood donors for IDA and BTT. The algorithm recommends doing an hemogram on all donor samples, routinely. Ferritin could be done only in microcytic samples. At levels lower than15 ng/ml, it is diagnosed as IDA, and therefore, HPLC is performed only for non-IDA samples with Ferritin levels higher than 15 ng/ml. By employing this algorithm, a substantial number of IDA and BTT could be diagnosed while keeping the number of Ferritin tests small and the number of HPLC tests even smaller and thus making it cost efficient.

  7. Genotyping of Kell, Duffy, Kidd and RHD in patients with beta Thalassemia / Genotipagem dos sistemas Kell, Duffy, Kidd e RHD em pacientes com beta Talassemia

    Scientific Electronic Library Online (English)

    Lilian, Castilho; Maria, Rios; Jordão, Pellegrino Jr; Maria H. M., Carvalho; Fernando L., Alberto; Sara T. O., Saad; Fernando F., Costa.

    2000-08-01

    Full Text Available A determinação dos fenótipos Rh, Kell, Duffy e Kidd, associada ao ABO é utilizada para prevenir a aloimunização a antígenos eritrocitários e participam também no processo de identificação de anticorpos nos pacientes com beta talassemia. Todavia, a fenotipagem desses pacientes é trabalhosa e de difíc [...] il interpretação. Nesta situação, deve ser avaliada uma alternativa ao teste de hemaglutinação para determinar o padrão antigênico dos pacientes. Utilizamos para tal fim o método PCR-RFLP. Foram preparados DNAs de 50 pacientes com beta talassemia que haviam sido anteriormente fenotipados pela hamglutinação e testados para Kell, Kidd, Duffy/GATA mutação por PCR-RFLP. RHD/não-D foi analisado pelo tamanho do produto, do PCR associado à seqüência do gene RHD no intron 4 e exon 10/3' UTR. Os testes de genotipagem foram realizados sem o conhecimento dos resultados dos fenótipos. Para os RHD/não-D, 47 foram RhD+ e RHD+/RHCE+, e 3 foram RhD- e RHD-/RHCE+. Para o Kell, 48 kk foram K2K2 e 2 Kk foram K1K2. Para o Duffy, das 44 amostras que haviam sido normais, GATA box, 8 Fy(a+b-) foram FYA/FYA, 15 Fy(a+b-) foram FYB/FYB e 19 Fy(a+b+) foram FYA/FYB; das outras 4 amostras, 3 foram FYA/FYB e heterozigoto GATA mutação, e 1 Fy(a-b-) era FYB/FYB, homozigoto GATA mutação. Duas amostras fenotipadas como Fy(a+b-), que eram normais GATA, apresentavam as mutações 265T/298A e 2 amostras fenotipadas como Fy(a-b+) haviam sido genotipadas como FYA/FYB. Para o Kidd, 15 Jk(a+b-) foram JKA/JKA, 12 Jk(a-b+) foram JKB/JKB, e 20 Jk(a+b+) foram JKA/JKB. Três amostras fenotipadas como JK(a+b+) haviam sido genotipadas como JKB/JKB. A genotipagem é mais acurada que a fenotipagem para determinação de grupos sangüíneos em pacientes portadores de beta talassemia politransfundidos. A genotipagem nesses pacientes pode ser importante para selecionar hemácias antigenicamente negativas para transfusão de glóbulos vermelhos. Abstract in english Determination of Rh, Kell, Duffy and Kidd phenotypes in addition to ABO is used to prevent the alloimmunization to red blood cells (RBCs) antigens and as part of the antibody identification process in patients with beta Thalassemia. However, phenotyping in these patients can be time consuming and di [...] fficult to interpret. In these situations, it would be valuable to have an alternative to hemagglutination tests to determine the patient's antigen profile. We used PCR-RFLP to genotype such patients. DNA was prepared from 50 patients with beta Thalassemia who had been phenotyped by routine hemagglutination, and tested for Kell, Kidd, Duffy/GATA mutation by PCR-RFLP. RHD/non-D was analysed by PCR product size associated to RHD gene sequence in intron 4 and exon 10/3'UTR. The genotyping assays were performed without knowledge of phenotype results. For RHD/non-D, 47 were RhD+ and RHD+/RHCE+, and 3 were RhD- and RHD-/RHCE+. For Kell, 48 kk were K2K2 and 2 Kk were K1K2. For Duffy, of 44 samples that had normal GATA box, 8 Fy(a+b-) were FYA/FYA, 15 Fy(a+b+) were FYB/FYB, and 19 Fy(a+b+) were FYA/FYB; of the other 4 samples 3 were FYA/FYB and heterozygous GATA mutation, and 1 Fy(a-b-) was FYB/FYB, homozygous GATA mutation. Two samples phenotyped as Fy(a+b-) that had normal GATA , presented the 265T/298A mutations and two samples phenotyped as Fy(a-b+) were genotyped was FYA/FYB.. For Kidd , 15 Jk(a+b) were JKA/JKA, 12 Jk(a-b+) were JKB/JKB, and 20 Jk(a+b+) were JKA/JKB. Three samples phenotyped as JK(a+b+) were genotyped as JKB/JKB. Genotype is more accurate than phenotype for determination of blood groups in polytransfused patients with betaThalassemia. Genotyping in these patients can be helpful to select antigen-negative RBCs for transfusion.

  8. Detection of two rare beta-thalassemia alleles found in the Tunisian population: codon 47 (+A) and codons 106/107 (+G).

    Science.gov (United States)

    Bibi, Amina; Messaoud, Taieb; Beldjord, Cherif; Fattoum, Slaheddine

    2006-01-01

    We here present the first report of the detection of two rare beta0-thalassemia (thal) mutations in the Tunisian population: codon 47 (+A) and codons 106/107 (+G). To the best of our knowledge this is the second report of the codon 47 (+A) mutation, the first being identified in a Surinamese subject. The codons 106/107 (+G) mutation was first described in American Blacks, subsequently in Egyptians and Palestinians, and now in Tunisians. These mutations were detected by denaturing gradient gel electrophoresis (DGGE) screening followed by automated nucleotide sequencing. The former was found in two related beta-thal major patients in the homozygous state, while the latter was identified in a homozygous state in a transfusion-dependent beta-thal subject and in a sickle cell beta-thal patient. Both mutations are in linkage disequilibrium with haplotype V and sequence framework 2. Given the known wide spectrum of beta-thal alleles in the Tunisian population, the present report further confirms such heterogeneity. The knowledge of an updated spectrum of beta-thal alleles in Tunisia must allow the implementation of a more efficient screening strategy for genetic counseling and prenatal diagnosis. PMID:16987798

  9. Identification of low frequency anti-erythrocyte antibodies in chronically transfused patient with beta-thalassemia: a case report

    Directory of Open Access Journals (Sweden)

    Ana Rúbia Magalhães Ferreira

    2015-02-01

    Full Text Available The rate of erythrocyte alloimmunization in tranfusion-dependent patients can reach 50%, although the frequency of clinically relevant antibodies in transfused patients is not fully known, it is estimated that about 1% of patients are sensitized to each unit of transfused RBCs. The aim of this study is to report the case of  an 11-year-old girl with ?-thalassemia major, chronically transfused, which was detected in pre-transfusion protocol, the presence of two rare anti-erythrocyte antibodies: anti-Colton b (anti-Cob and anti-Lutheran 14 (anti-Lu14. To survey the clinical and laboratory patient history, research records filed in the archives of the university hospital in which the patient is monitored system was performed. The phenotyping erythrocyte in multitransfused patients is essential to decrease the risk of complications due to alloimmunization and estimate the availability of compatible blood. Thus, the report of this case may contribute to increase knowledge about of the real frequency of uncommon anti-erythrocyte antibodies in thalassemic patients.

  10. Polymorphic variations influencing fetal hemoglobin levels: association study in beta-thalassemia carriers and in normal individuals of Portuguese origin.

    Science.gov (United States)

    Pereira, Clara; Relvas, Luís; Bento, Celeste; Abade, Augusto; Ribeiro, M Letícia; Manco, Licínio

    2015-04-01

    Three major loci have been associated with HbF levels, including -158C/T (XmnI) at HBG2 promoter region, and several polymorphisms at BCL11A intron-2 and HBS1L-MYB (HMIP) intergenic region. Mutations in the KLF1 gene were recently associated with increased HbF levels. This study aims to evaluate whether genetic variability at these loci influences HbF levels in ?-thalassemia carriers and in normal individuals of Portuguese origin. Sixty five ?-thalassemia carriers, HbF levels ranging from 0.2% to 9.5%, and 60 individuals with normal hematological parameters, HbF levels ranging from 0.2% to 7.4%, were selected for this study. In ?-thal carriers linear regression models revealed a strong statistical significant association for HBG2 (XmnI) rs7482144 (?=0.455; P=5.858×10(-7)), and nominal significance for BCL11A rs766432 (?=0.215; P=0.029) and HMIP rs9399137 (?=0.209; P=0.011). In normal individuals, a case (HbF>2%; n=15) vs. control (HbFBCL11A SNPs rs11886868 (OR=4; P=0.001), rs766432 (OR=3.7; P=0.002) and rs7606173 (OR=0.36; P=0.032). KLF1 rs3817621 was not found associated with HbF levels. Our results suggest that in Portuguese ?-thal carriers the HBG2 XmnI polymorphism is strongly associated with HbF levels. In normal individuals, BCL11A polymorphisms, but not HMIP or HBG2 (XmnI) loci, are nominally associated with HbF expression. PMID:25842369

  11. Nonsense-mediated decay mechanism is a possible modifying factor of clinical outcome in nonsense cd39 beta thalassemia genotype

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    Maria Concetta Renda

    2012-11-01

    Full Text Available Nonsense-mediated mRNA decay (NMD is a surveillance system to prevent the synthesis of non-functional proteins. In ?-thalassemia, NMD may have a role in clinical outcome. An example of premature translation stop codons appearing for the first time is the ?-globin cd39 mutation; when homozygous, this results in a severe phenotype. The aim of this study was to determine whether the homozygous nonsense cd39 may have a milder phenotype in comparison with IVS1,nt110/cd39 genotype. Genotypes have been identified from a cohort of 568 patients affected by ?-thalassemia. These genotypes were compared with those found in 577 affected fetuses detected among 2292 prenatal diagnoses. The nine most common genotypes, each with an incidence rate of 1.5% or over, and together accounting for 80% of genotype frequencies, underwent statistical analysis. Genotype prevalence was calculated within the overall group. Results are expressed as proportions with 95% confidence intervals; P?0.05 was considered statistically significant. A binomial distribution was assumed for each group; z-tests were used to compare genotype frequencies observed in the patient group with frequencies in the affected fetus group. In the absence of selecting factors, prevalence of these two genotypes was compared between a cohort of 568 ?-thalassemia patients (PTS and 577 affected fetuses (FOET detected during the same period. IVS1,nt110/cd39 was significantly more prevalent in FOET than PTS (P<0.0001, while there was no significant difference in prevalence of cd39/cd39 in FOET compared with PTS (P=0.524. These results suggest a cd39 genotype NMD mechanism may be associated with improved clinical outcomes in thalassemia major. ?????mRNA ???NMD? ?????????????????????????????NMD?????????????????????????PTC??????cd39???????????????????????????IVS1,nt110/cd39???????????cd39???????????????568?????????????????2292??????????577?????????????????9?????????????????????????1.5%????????????80%????????????????????95%????????P?0.05??????????????????????Z??????????????????????????????? ???????????568??????????PTS???????????577?????????FOET????????????IVS1,nt110/cd39?FOET?????????PTS?P<0.0001????cd39/cd39 ?FOET?PTS?P=0.524????????????????????cd39???NMD????????????????????

  12. Community genetics and health approaches for bringing awareness in tribals for the prevention of beta-thalassemia in India

    Directory of Open Access Journals (Sweden)

    Ranbir S. Balgir

    2011-08-01

    Full Text Available Beta (β thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of β-globin chains. In the homozygous state, β-thalassemia (i.e., thalassemia major causes severe transfusion-dependent anemia. Inherited β-thalassemia syndromes cause high degree of hemolytic anemia, recurrent fever, clinical jaundice, frequent infections, bossing of cheek bones, growth retardation, splenomegaly, etc. and are responsible for high infant morbidity, mortality and fetal wastage in India. The victims include the infants, growing children, adolescent girls, pregnant women and a large chunk of ignorant people. In view of heavy genetic load, frequent requirement of blood transfusions, high cost of treatment and management, physical trauma, and mental and psychological harassment to the patients and their families, it has been realized that preventive community health and genetics approach is the most suitable for India. After carrier detection, prenatal diagnosis, and genetic couselling are the important options for couples at high risk for β-thalassemia. A prerequisite for successful prevention and intervention approach in India is the health education, bringing public awareness, sensitization, and community screening for the identification of heterozygotes or carriers in the concerned community. Some suggestions for the prevention of β-thalassemia in the vulnerable communities of India have been over emphasized for amelioration.β地中海贫血综合症是一簇遗传性异常,其特点是β球蛋白链接合处基因缺失。β地贫(或重型地贫)在纯和状态下导致严重的输液依赖型贫血症。遗传性的β地贫综合症引起严重的溶血性贫血、回归热、显性黄疸、常见感染、疼痛危象、颊骨浮肿、生长迟缓、脾肿大等症状,这导致在印度出现婴儿高发病率、死亡率和胎儿夭折。其受害人群包括婴儿、发育中的儿童、青春期女生、孕妇和大量无辜的人。由于该病症基因负荷重,通常需要对患者进行输血、高额治疗和护理,并对患者及其家人造成物理创伤、心理和生理困扰。印度人已认识到最适合治疗该症的方法是预防性社区卫生和基因学方法。载波检测后,β地贫高风险夫妇有必要进行产前诊断和遗传咨询。要在印度成功预防和干预该病症的蔓延,首先需要做的是:实施健康教育、提高公众意识、地贫敏感化、在相关社区进行杂合子或载波筛查以鉴定。为降低印度高发区的发病率,某些β地贫预防措施已被高度重视。

  13. Identification of novel microsatellite markers <1 Mb from the HBB gene and development of a single-tube pentadecaplex PCR panel of highly polymorphic markers for preimplantation genetic diagnosis of beta-thalassemia.

    Science.gov (United States)

    Chen, Min; Tan, Arnold S C; Cheah, Felicia S H; Saw, Eugene E L; Chong, Samuel S

    2015-12-01

    Beta (?)-thalassemia is one of the most common monogenic diseases worldwide. Affected pregnancies can be avoided through preimplantation genetic diagnosis (PGD), which commonly involves customized assays to detect the different combinations of ?-globin (HBB) gene mutations present in couples, in conjunction with linkage analysis of flanking microsatellite markers. Currently, the limited number of reported closely linked markers hampers their utility in indirect linkage-based PGD for this disorder. To increase the available markers closely flanking the HBB gene, an in silico search was performed to identify all markers within 1 Mb flanking the HBB gene. Fifteen markers with potentially high polymorphism information content (PIC) and heterozygosity values were selected and optimized into a single-tube pentadecaplex PCR panel. Allele frequencies and polymorphism and heterozygosity indices of each marker were assessed in five populations. A total of 238 alleles were observed from the 15 markers. PIC was >0.7 for all markers, with expected heterozygosity and observed heterozygosity values ranging from 0.74 to 0.90 and 0.72 to 0.88, respectively. Greater than 99% of individuals were heterozygous for at least seven markers, with at least two heterozygous markers on either side of the HBB gene. The pentadecaplex marker assay also performed reliably on single cells either directly or after whole genome amplification, thus validating its use in standalone linkage-based ?-thalassemia PGD or in conjunction with HBB mutation detection. PMID:26331357

  14. Egyptian Fractions Revisited

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    Olga KOSHELEVA

    2009-04-01

    Full Text Available It is well known that the ancient Egyptians represented each fraction as a sum of unit fractions - i.e., fractions with unit numerators; this is how they, e.g., divided loaves of bread. What is not clear is why they used this representation. In this paper, we propose a new explanation: crudely speaking, that the main idea behind the Egyptian fractions provides an optimal way of dividing the loaves. We also analyze the related properties of fractions.

  15. Interação entre Hb C [beta6(A3)Glu>Lys] e IVS II-654 (C>T) beta-talassemia no Brasil / Hb C [beta6(A3)Glu>Lys] and IVS II - 654 (C>T) beta thalassemia interaction in Brazil

    Scientific Electronic Library Online (English)

    Claudia R., Bonini-Domingos; Ana C., Bonini-Domingos; Ana R., Chinelato; Paula J. A., Zamaro; Patrícia H. O., Calderan.

    2003-06-01

    Full Text Available [...] Abstract in english Thalassemias are a heterogeneous group of inherited disorders characterized by a microcytic hypochromic anemia and an imbalance in the synthesis of the globin-chains. Hb C is the second most frequently variant of hemoglobin found in Brazil. The laboratory diagnosis of hemoglobinopathies, including t [...] halassemias, is growing in importance, particularly because of an increasing requirement for neonatal diagnosis of abnormal hemoglobins. Screening tests were carried out using alkaline and acid electrophoresis, globin-chain analysis by cellulose acetate in alkaline pH, isoelectric focusing and HPLC. The molecular characterization was made by PCR-ASO for Hb C and beta thalassemia mutants. Large-scale screening and discriminative methodologies must provide information about the hemoglobin polymorphisms in Brazilian population. HPLC is a powerful tool in these cases. Molecular characterization is important to genetic counseling and clinical management, in particular for the Brazilian population that have an intense racial admixture, with great variability of hemoglobins. In this paper an association between Hb C and beta thalassemia (IVS-II-654) in a black family from Brazil was described.

  16. JIT implementation in Egyptian manufacturing firms: some empirical evidence

    OpenAIRE

    Salaheldin, S.I.

    2005-01-01

    Abstract: Purpose – This study aims to delineate the major human modifications to be undertaken prior to just-in-time (JIT) implementation in Egyptian manufacturing firms; to discern the benefits obtained from JIT implementation; to identify the problems that Egyptian manufacturing companies typically encounter in implementing JIT philosophy; and to explore the relationship between human modification efforts to be undertaken prior to JIT implementation and JIT success. Design/methodology...

  17. Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper Egypt.

    Directory of Open Access Journals (Sweden)

    Fahim M Fahim

    2013-12-01

    Full Text Available The aim of this study is to assess the growth parameters, vitamin D, calcium, and phosphorous status in children with thalassemia major receiving packed red cells transfusion with chelation therapy.In a case control study, 100 patients with beta thalassemia major (aged from 4 to 15 years were compared with 100 sex- and age-matched children serves as a control group. Anthropometric measurement, Serum level of calcium, phosphorus and vitamin D (25 hydroxycholecalciferol were estimated for all patients & controls.49% of our patients had short stature. 47% were underweight. BMI of 43 (43% patients were low. The mean total serum calcium (6.6±1.2 mg/dl and 25-hydroxycholecalciferol (25-OH Vit D (10.4±4.6 mcg/dl levels were significantly lower in our patients than in controls (10.2±1.06 mg/dl and 40.2±12.3 mcg/dl, respectively; each P< 0.001.Children with beta thalassemia major have delayed growth and metabolic abnormalities that signify the importance of therapeutic interventions. The presence of these abnormalities may be due to iron overload and poor nutritional support.

  18. [Beta thalassemia: motivation for screening in Terni].

    Science.gov (United States)

    Fatati, G; Palazzesi, G P; Cassetti, M; Lorenzoni, L; Coaccioli, S; Puxeddu, A

    1984-11-10

    There are no definitive data on the frequency of beta-thalassaemia in the Province of Terni; a mass screening programme has not been carried out. Preliminary studies confirm that there is a strong incidence of beta-thalassaemia heterozygotes. A theory can be put forward for the presence of beta-thalassaemia trait, based on the notion of the multicentric genesis of the disorder: the malaria may have been the dominant selective factor. PMID:6514214

  19. Graves' disease mimicking beta-thalassemia trait.

    OpenAIRE

    Akasheh, M. S.

    1994-01-01

    A case of Graves' disease associated with splenomegaly, lymphadenopathy, microcytic hypochromic anaemia, and a raised haemoglobin A2 is presented. The haematological indices returned to normal after conventional treatment with anti-thyroid medication.

  20. Serum ferritin levels, socio-demographic factors and desferrioxamine therapy in multi-transfused thalassemia major patients at a government tertiary care hospital of Karachi, Pakistan

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    Rehman Anis

    2011-08-01

    Full Text Available Abstract Background Beta thalassemia is the most frequent genetic disorder of haemoglobin synthesis in Pakistan. Recurrent transfusions lead to iron-overload manifested by increased serum Ferritin levels, for which chelation therapy is required. Findings The study was conducted in the Pediatric Emergency unit of Civil Hospital Karachi after ethical approval by the Institutional Review Board of Dow University of Health Sciences. Seventy nine cases of beta thalassemia major were included after a written consent. The care takers were interviewed for the socio-demographic variables and the use of Desferrioxamine therapy, after which a blood sample was drawn to assess the serum Ferritin level. SPSS 15.0 was employed for data entry and analysis. Of the seventy-nine patients included in the study, 46 (58.2% were males while 33 (41.8% were females. The mean age was 10.8 (± 4.5 years with the dominant age group (46.2% being 10 to 14 years. In 62 (78.8% cases, the care taker education was below the tenth grade. The mean serum Ferritin level in our study were 4236.5 ng/ml and showed a directly proportional relationship with age. Desferrioxamine was used by patients in 46 (58.2% cases with monthly house hold income significant factor to the use of therapy. Conclusions The mean serum Ferritin levels are approximately ten times higher than the normal recommended levels for normal individuals, with two-fifths of the patients not receiving iron chelation therapy at all. Use of iron chelation therapy and titrating the dose according to the need can significantly lower the iron load reducing the risk of iron-overload related complications leading to a better quality of life and improving survival in Pakistani beta thalassemia major patients. Conflicts of Interest: None

  1. Autopsy of an Egyptian mummy (Nakht--ROM I)

    OpenAIRE

    1980-01-01

    Autopsy of a 3200-year-old Egyptian mummy by an international multidisciplinary team yielded much information about diseases of the ancient past. Major contributions were made by the disciplines of anatomy, dentistry, genetics, hematology, histology, microbiology, nuclear medicine, occupational medicine, orthopedic surgery, otolaryngology, pathology, pediatrics, plastic surgery, radiology and virology. Scientists from Toronto, Detroit, Philadelphia and Cardiff participated in the investigatio...

  2. Unexpected links between Egyptian and Babylonian mathematics

    CERN Document Server

    Friberg, Jöran

    2005-01-01

    Mesopotamian mathematics is known from a great number of cuneiform texts, most of them Old Babylonian, some Late Babylonian or pre-Old-Babylonian, and has been intensively studied during the last couple of decades. In contrast to this Egyptian mathematics is known from only a small number of papyrus texts, and the few books and papers that have been written about Egyptian mathematical papyri have mostly reiterated the same old presentations and interpretations of the texts. In this book, it is shown that the methods developed by the author for the close study of mathematical cuneiform texts can also be successfully applied to all kinds of Egyptian mathematical texts, hieratic, demotic, or Greek-Egyptian. At the same time, comparisons of a large number of individual Egyptian mathematical exercises with Babylonian parallels yield many new insights into the nature of Egyptian mathematics and show that Egyptian and Babylonian mathematics display greater similarities than expected.

  3. Effects of Blood Transfusion on Exercise Capacity in Thalassemia Major Patients

    Science.gov (United States)

    Benedetto, Daniela; Rao, Carmelo Massimo; Cefalù, Claudia; Aguglia, Demetrio Oreste; Cattadori, Gaia; D’Ascola, Domenico Giuseppe; Benedetto, Frank Antonio; Agostoni, Piergiuseppe; Sciomer, Susanna

    2015-01-01

    Anemia has an important role in exercise performance. However, the direct link between rapid changes of hemoglobin and exercise performance is still unknown.To find out more on this topic, we studied 18 beta-thalassemia major patients free of relevant cardiac dysfunction (age 33.5±7.2 years,males = 10). Patients performed a maximal cardiopulmolmonary exercise test (cycloergometer, personalized ramp protocol, breath-by-breath measurements of expired gases) before and the day after blood transfusion (500 cc of red cell concentrates). After blood transfusion, hemoglobin increased from 10.5±0.8 g/dL to 12.1±1.2 (p<0.001), peak VO2 from 1408 to 1546mL/min (p<0.05), and VO2 at anaerobic threshold from 965 to 1024mL/min (p<0.05). No major changes were observed as regards heart and respiratory rates either at peak exercise or at anaerobic threshold. Similarly, no relevant changes were observed in ventilation efficiency, as evaluated by the ventilation vs. carbon dioxide production relationship, or in O2 delivery to the periphery as analyzed by the VO2 vs. workload relationship. The relationship between hemoglobin and VO2 changes showed, for each g/dL of hemoglobin increase, a VO2 increase = 82.5 mL/min and 35 mL/min, at peak exercise and at anaerobic threshold, respectively. In beta-thalassemia major patients, an acute albeit partial anemia correction by blood transfusion determinates a relevant increase of exercise performance, observed both at peak exercise and at anaerobic threshold. PMID:26010540

  4. Effect of Hypertransfusion on Extramedullary Hematopoietic Compression Mass in Thalassemia Major: A Case Report

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    Mohammadreza Emamhadi

    2012-01-01

    Full Text Available Hereby we report a patient with thalassemia major having extradural cord compression at T3-T9 levels due to a mass of extramedullary hematopoiesis (EMH tissue, whose treatment was successful with hypertransfusion therapy alone. The patient was a 23-year-old man who had not received regular blood transfusion since two years before admission. He suffered from paraparesis with a history of progressive lower limb weakness for 2 months. MRI of the spinal cord demonstrated thoracic extramedullary hematopoietic mass causing spinal cord compression. The patient demonstrated a significant response to hypertransfusion and improvement in the neurologic status started a few days after treatment. Almost complete resolution of the mass was seen in spinal MRI one week after hypertransfusion. Hypertransfusion seems to be a useful method for treatment of spinal cord compression due to a hematopoietic mass. It may be used as the first line therapy.Keywords: Beta-Thalassemia,Hypertransfusion,Spinal Cord Compression

  5. Ottoman Perception of Egyptian Students

    Science.gov (United States)

    Yilmaz, Ali

    2015-01-01

    This research was carried out before the period described as "Arab Spring" in Egypt which is one of the highly effective countries of Middle East in political, economic and demographic structuring. The aim was to determine the Ottoman Turks image of Egyptian secondary school third grade students. Descriptive scanning model out of…

  6. Evaluation of Glucose Metabolism, Thyroid Function, Growth and Development Pattern and Calcium Status in Patients with Thalassemia Major

    Directory of Open Access Journals (Sweden)

    2008-01-01

    Full Text Available Thalassemia major is a genetic disorder. Blood transfusion is critical for survival in these patients. Over the course of the past two and three decade`s hypertransfusion therapy in these patients has increased significant improvement in life expectancy and quality of life. Unfortunately, this type of therapy increased the frequency of complication due to iron overloud. In the past endocrine abnormalities were very common in beta-thalassemia patients but it is more common now. The aim of this study was evaluation of prevalence of endocrine disturbances in patients with thalassemia major greater than 10 years old. Fifty six patients with thalassemia major greater than 10 years enrolled. Physicians collected demographic data and history of therapies as well as menstrual history in female. Patients have been examined to determine their pubertal status and SDS of height for evaluation of short stature. For evaluation of glucose tolerance, fasting blood glucose and oral glucose tolerance test were performed. Serum level of calcium, phosphorous, thyroid stimulating hormone, free thyroxin, luteinizing hormone and follicular stimulating hormone, estradiol in girls and testosterone in boys were measured. Fifty six patients with thalassemia major 10-27 years old were evaluated. In this study prevalence of diabetes mellitus, impaired fasting glucose and impaired glucose tolerance test were 8.9, 28.6 and 7.1%, respectively. Short stature (SDS= -2 was seen in 70 of boys and 73% of girls. Hypocalcaemia and primary overt hypothyroidism were present in 41 and 16%, respectively. 14.3% of our patients have not any endocrine abnormalities. Despite recent therapy with Desferal in the management of beta-thalassemia major, the risk of secondary endocrine dysfunction remains high. Hypogonadism is one of the most frequent endocrine complications. Endocrine evaluation in patients with thalassemia major must be carried out regularly especially in those patients over the age of 10 years in tabriz.

  7. Risk Factors for Coronary Artery Disease in Egyptian Women

    OpenAIRE

    Bahnasawy MH*; Habbak LZ*; Al-Ashry MA** and Al-Maie MM

    2013-01-01

    Introduction: Coronary artery disease (CAD) is a major public health problem both in developed and in developing countries. The disease is multifactorial and many predisposing risk factors are responsible for this disease. The present study was performed to determine the prevalence of CAD risk factors among Egyptian women at Damietta governorate. Patients and methods: The study was based on investigation of 113 randomly chosen women who had CAD. Demographic data, risk factors were determin...

  8. Study on effectiveness of transfusion program in thalassemia major patients receiving multiple blood transfusions at a transfusion centre in Western India

    Directory of Open Access Journals (Sweden)

    Shah Neeraj

    2010-01-01

    Full Text Available Background : Children suffering from beta-thalassemia major require repeated blood transfusions which may be associated with dangers like iron overload and contraction of infections such as HIV, HCV, and HBsAg which ultimately curtail their life span. On the other hand, inadequate transfusions lead to severe anemia and general fatigue and debility. Materials and Methods: Data were obtained from 142 beta-thalassemia major patients aged 3 years or more receiving regular blood transfusions at a transfusion centre in Western India from 1 April 2009 to 30 June 2009. The clinical data and laboratory results were subsequently analyzed. Results: Of the 142 patients, 76 (53.5% were undertransfused (mean Hb <10 gm%. 96 (67% of the patients were taking some form of chelation therapy but out of them only 2 (2% were adequately chelated (S. ferritin <1000 ng/ml. 5 (3.5% of the patients were known diabetics on insulin therapy. 103 (72% of the patients were retarded in terms of growth. The prevalence of transfusion-transmitted infections (TTIs such as HCV, HIV, and HBsAg was respectively 45%, 2%, and 2%, with the prevalence of HCV being significantly more than the general population. The HCV prevalence showed positive correlation with the age of the patients and with the total no of blood transfusions received. As many as 15% (6 out of 40 children who were born on or after 2002 were HCV positive despite the blood they received being subjected to screening for HCV. Conclusions: The study suggests the need to step up the transfusions to achieve hemoglobin goal of 10 gm% (as per the moderate transfusion regimen and also to institute urgent and effective chelation measures with the aim of keeping serum ferritin levels below 1000 ng/ml to avoid the systemic effects of iron overload. In addition, strict monitoring of the children for endocrinopathy and other systemic effects of iron overload should be done. Rigid implementation of quality control measures for the ELISA kits used to detect HCV in donor blood needs to be done urgently. Alternately, more sensitive and specific measures (like NAT testing should be employed for detection of HCV. In the absence of a definitive cure accessible and available to all patients, strict implementation of the above suggested measures will go a long way in improving the quality (and quantity of life in patients of beta-thalassemia major.

  9. Extraordinarily Egyptian Jewelry Fit for a Pharaoh.

    Science.gov (United States)

    Patterson, Berniece

    1999-01-01

    Presents an art lesson for sixth-grade students in which the students study the Egyptians' jewelry techniques and designs and create their own amulets. Provides background information on the importance of life after death to the Egyptians and how religion influenced the designing of their amulets. Describes the jewelry-making procedure. (CMK)

  10. Detection of a major gene for heterocellular hereditary persistence of fetal hemoglobin after accounting for genetic modifiers

    Energy Technology Data Exchange (ETDEWEB)

    Thein, S.L.; Weatherall, D.J. (Institute of Molecular Medicine, Oxford (United Kingdom)); Sampietro, M.; Rohde, K.; Rochette, J.; Lathrop, G.M.; Demenais, F.

    1994-02-01

    [open quotes]Heterocellular hereditary persistence of fetal hemoglobin[close quotes] (HPFH) is the term used to describe the genetically determined persistence of fetal hemoglobin (Hb F) production into adult life, in the absence of any related hematological disorder. Whereas some forms are caused by mutations in the [beta]-globin gene cluster on chromosome 11, others segregate independently. While the latter are of particular interest with respect to the regulation of globin gene switching, it has not been possible to determine their chromosomal location, mainly because their mode of inheritance is not clear, but also because several other factors are known to modify Hb F production. The authors have examined a large Asian Indian pedigree which includes individuals with heterocellular HPFH associated with [beta]-thalassemia and/or [alpha]-thalassemia. Segregation analysis was conducted on the HPFH trait FC, defined to be the percentage of Hb F-containing cells (F-cells), using the class D regressive model. The results provide evidence for the presence of a major gene, dominant or codominant, which controls the FC values with residual familial correlations. The major gene was detected when the effects of genetic modifiers, notably [beta]-thalassemia and the XmnI-[sup G][gamma] polymorphism, are accounted for in this analysis. Linkage with the [beta]-globin gene cluster is excluded. The transmission of the FC values in this pedigree is informative enough to allow detection of linkage with an appropriate marker(s). The analytical approach outlined in this study, using simple regression to allow for genetic modifiers and thus allowing the mode of inheritance of a trait to be dissected out, may be useful as a model for segregation and linkage analyses of other complex phenotypes. 39 refs., 4 figs., 6 tabs.

  11. Unrelated Umbilical Cord Blood Transplant for Children with ?-Thalassemia Major.

    Science.gov (United States)

    Shah, Sandip A; Shah, Kamlesh M; Patel, Kinnari A; Anand, Asha S; Talati, Shailesh S; Panchal, Harsha P; Patel, Apurva A; Parikh, Sonia K; Parekh, Bhavesh B; Shukla, Shilin N; Raut, Shreeniwas S

    2015-03-01

    Beta thalassemia major, one of the most prevalent hemoglobinopathy throughout the word, can be cured by allogenic stem cell transplantation (SCT) (Bone Marrow Transplant 36:971-975, 2005). Many patients, however, lack a suitably matched related sibling donor. Unrelated umbilical cord blood (UCB) can be used as an alternative stem cell source for these patients. This report describes SCT for nine children with beta-thalassemia major using partially HLA-matched unrelated UCB. Conditioning included oral busulfan 16 mg/kg (day -10 to -7), cyclophosphamide (Cy) 200 mg/kg (day -5 to -2), fludarabine 90 mg/kg (day -13 to -11), and antithymocyte globulin (rabbit) 7.5 mg/kg (day -3 to -1). The infused cell dose was 10.71 × 10(7)/kg total nucleated cells (TNC) (range 6.5-17 × 10(7)/kg TNC). The patients ranged in age from 1.5 to 7 years, in weight from 10.5 to 17 kg. A second transplant with two unrelated cord blood units was attempted in two patients who had primary graft failure. The retransplant recipients were preconditioned with i.v Cy 120 mg/kg (day -3 to -2). Five of the nine patients engrafted promptly with 50-100 % donor chimerism (56 %). They engrafted at a median of 17 days (range 12-19). One patient is transfusion free for 36 months; a second patient is transfusion free for 18 months and a third is transfusion free for 9 months. There was no transplant related mortality. Four of the nine children had autologous recovery without engraftment. Primary graft rejection is the major complication. Post transplant complications were mild hepatic veno-occlusive disease, acute GVHD grade II, and CMV interstitial pneumonia. The chronic GVHD was limited and could be controlled by Methylprednisolone combined with Mycophenolate. The lack of a marrow donor registry in India makes UCBT from related and unrelated donors a good alternative. Transplant should be delayed until the child is at least 18 months of age. The dose of UCB stem cells is the most important factor for engraftment. UCB has the advantages of rapid availability and low risk of severe GVHD despite donor-recipient HLA disparity (Transplant Proc 37:2667-2669, 2005). We demonstrate the feasibility of this procedure in the setting of a developing country. PMID:25548438

  12. Egyptian Agricultural Exports Competitiveness

    OpenAIRE

    Soliman, Ibrahim; Bassiony, Hala

    2012-01-01

    The study dealt with the competitiveness of Egypt’s agricultural exports for the major commodity groups: Meat and meat preparations, Dairy products and bird eggs, Cereals and cereals preparations, Vegetables and Fruits, Sugar, sugar preparations and honey, Feeding stuff of animals, Beverages, Tobacco, Oils and fats, and Textile fiber and their waste. The study has not restricted the estimated measure of the competitiveness to only the classical Revealed Comparative Advantage Index (RCA), ...

  13. Conservation of a Rare Painted Ancient Egyptian Textile Object from the Egyptian Museum in Cairo

    OpenAIRE

    Yasin Zidan; Omar Abdel-Kareem; Nadia Lokma; Hanaa Ahmed

    2008-01-01

    This study describes conservation of a painted ancientEgyptian textile object from the collection of Osiris clothsin the Egyptian Museum in Cairo, Egypt. An evaluation ofthe reactivation consolidation technique to reinforcementof ancient Egyptian painted textiles was performed.Various investigation methods were carried out to identifythe fibres, paints, and other materials, which are part ofthe selected object. The condition of the object was alsoinvestigated. Newly prepared painted linen tex...

  14. Egyptian and foreign cigarettes Pt. 1

    International Nuclear Information System (INIS)

    NAA was employed to determine the concentration of 27 elements in an Egyptian cigarette filter before and after smoking. The filter of three foreign cigarette brands were also analyzed and compared to the Egyptian brand. The elements determined are Al, As, Ba, Br, Ce, Cl, Co, Cr, Cs, Eu, Fe, Hf, K, La, Mg, Mn, Na, Ni, Rb, Sb, Sc, Se, Sr, Th, Ti, V and Zn. It was observed that the concentration of the measured elements in the Egyptian brand were within the concentration range of foreign brands, and that the concentration of As, Br, Cl, K, Na and Se in the filters increased after smoking regardless the brands examined. (author)

  15. Biodiesel, the Egyptian experience

    Energy Technology Data Exchange (ETDEWEB)

    Heikal, E.K.; Abdou, I.K. (Egyptian Petroleum Research Inst., Cairo (Egypt)), E-mail: S_a_khali@yahoo.com

    2009-07-01

    Biodiesel has recently become more attractive because of its environmental benefits and the fact that it is produced from renewable resources. In recent years, research has been directed to explore plant-based oil and fats as sources for biodiesel fuels. Under Egypt's land and water supply availabilities only non- edible plants such as Jatropha, which can be grown on a large scale on noncropped marginal land and wasteland, can be considered for biodiesel production. Jatropha biodiesel fuel could be an economical alternative blending stock for diesel fuel in Egypt. Cars could be run with Jatropha biodiesel fuel without any change in motor design. The major problem associated with the use of 100 % vegetable biodiesel fuels is caused by the high fuel viscosity, besides their high pour points. (orig.)

  16. The Future of SMEs in Egyptian Economy

    OpenAIRE

    Alasrag, Hussien

    2007-01-01

    Small and Medium Enterprises (SMEs) in Egypt represent the greatest share of the productive units of the Egyptian economy, the current national policy directions address ways and means of developing the capacities of SMEs. This paper reviews the role of The Developmental Role of SMEs in Egyptian Economy. IT attempts at identifying the broad parameters within which an integrated government policy towards SME development can be formulated. The paper identifies the financial and non-financial co...

  17. [Egyptian mummies as anthropological artifacts].

    Science.gov (United States)

    Bergamini, Giovanni

    2013-01-01

    Ancient human remains like Egyptian mummified bodies cannot be considered on a physical anthropological perspective only. So severe and invasive were the operations on the body, so various were the materials involved in the preservation techniques, so complicated was the embalming and wrapping procedure according to specific rituals, that the final result, the mummy, is to be considered a highly composite product. The human remains are a relevant part of it indeed, but a very wide set of information can be taken.also from the other components, relating to environment, resources, technology, religious beliefs, cultural and technical traditions, skills and arts at the time of the individual's life. That a plain anthropological approach could not be exhaustive on cataloguing such a kind of archaeological finds emerged during the sessions of the scientific board charged by the Italian ICCD of defining a data track for filing anthropological remains as a special kind of cultural heritage. PMID:25807707

  18. Radiological assessment of the Egyptian Mediterranean coast

    International Nuclear Information System (INIS)

    On the basis of extensive sampling, gamma spectrometry, laboratory analyses, data evaluation and comparison with the reference data, the following assessment has been carried out. The radiological assessment has been done for a wide scale study area (about 1100 km) from El- Salloum in the west of the Mediterranean coast of Egypt to El-Arish in the east. The environmental radiological assessment steps are based on the criteria previously mentioned. The sources of radioactivity possibly reach the Egyptian Mediterranean coast can be summarized as: primordial and radiogenic radionuclides (e.g. 40K, 238U and 232Th series), cosmic rays and cosmogenic radionuclides (e.g. 7Be), fertilizers (e.g. superphosphate), black sand (transported by Nile River), fallout (either from nuclear testing or Chernobyl), seawater currents (transported either natural or man-made), Suez Canal (subject to receive a radioactive releasing and effluents from either nuclear power ships or submarines passes through the canal), biological migration and sedimentary longshore movement (e.g. Anguilla anguilla), atmospheric radioactivity (e.g. 222Rn and its daughters), domestic and medical sewage (minor source, short half-life), depleted uranium dust (possibly), satellite and aircraft accident (accidentally) and rarely loss of industrial radioactive source (incidentally). El-Salloum, Rashid and El-Gamil have been considered as concentrated basins for the majority of the radioisotopes. This suggestion was due to the special topographical features of these three stations, which make the accumulation of the radioactive isotopes possible. Calculations of outdoor absorbed dose rate for human population at all stations under investigation from 238U, 232Th and 40K were carried out. The calculated absorbed dose rate has been distinguished the coast into normal areas and Rashid black sand area as high background area. The range of calculated dose was 8.39-38.5 ?Gy/h. Good agreement was observed with NCRP absorbed dose rates 26 (17-40) nGy/h. Calculations of gamma absorbed dose rate in Rashid black sand area collected in July 1998 recorded as 0.72 ?Gy/h. This value was considered as relatively high dose rate and it is remarkable of the high background radiation area at Rashid. Comparing with the reported gamma radiation dose rates in the others high background radiation areas, it was in agreement with Ramsar in Iran (0.7-50 ?Gy/h) and relatively lower than 1-2 ?Gy/h at Guarapari, Meaipe and Cumuruxatiba in Brazil. Annual intake radiation dose was achieved by estimation of the human intake of radioactivity due to fish consumption considering the Egyptian values. Using the mathematical calculation of annual dose per Bq, the total dose to a person, daily fed with 0.0136 kg fish, in one year was 10.3 ?Sv/y, which is mainly from 40K. Annual intake radiation dose was achieved by estimation of the human intake of radioactivity due to fish consumption considering the Egyptian values. Using the mathematical calculation of annual dose per Bq, the total dose to a person, daily fed with 0.0136 kg fish, in one year was 10.3 ?Sv/y, which is mainly from 40K. The only man-made radionuclide detected in the Egyptian Mediterranean coast is 137Cs with average value 0.37 Bq/kg. This average value shows high agreement with the other referenced values in the world. The main source of 137Cs is atmospheric fallout either from nuclear testing or Chernobyl. The marine transport from western Mediterranean could be considered as another source. Surface seawater salinity showed a positive correlation with the concentrations of 40K in surface seawater (r = 0.64). A mathematical model has been deduced to estimate the range of natural 40K in the surface seawater. Assessment of radioactivity bioaccumulators was made among different biota collected from the Egyptian Mediterranean coast. It revealed that, Patella spp., Anguilla spp. and Mytilus spp. were the best marine organisms for having the capability to accumulate 40K. Also, Patella spp., Ang uilla spp. and the intermediate leave of Posidonia s

  19. Some endocrinal aspects of pancreas in beta thalassemia

    International Nuclear Information System (INIS)

    The study was carried out to evaluate endocrinal aspects of the pancreas in thalassemia children, ages 5 - 10 years maintained under either regular or irregular iron chelation therapy. A matched control on healthy children, was included for comparison. As regards laboratory findings, fasting and post prandial blood sugar was significantly elevated in thalassemia children than the control and serum insulin was significantly lower in the irregular iron chelation group than both in the regular one and in the control group. Most cases of diabetic thalassemia children clinically and biochemically were of irregular iron chelation and with older age. They were frequently higher transfused. There is significant rise of serum ferritin in diabetic group than in diabetic thalassemia children. In conclusion, pancreatic dysfunction can be detected in thalassemia children, but regular iron chelation can reduce its occurrence. 10 tabs

  20. Radiological assessment of the Egyptian Mediterranean Coast

    International Nuclear Information System (INIS)

    On the basis of extensive sampling, gamma spectrometry, laboratory analyses, data evaluation and comparison with the reference data, the following assessment has been carried out. The radiological assessment has been done for a wide scale study area (about 1100 km) from El-Salloum in the west of the Mediterranean coast of Egypt to El-Arish in the east. The environmental radiological assessment steps are based on the criteria previously mentioned. The sources of radioactivity possibly reach the Egyptian Mediterranean coast can be summarized as: primordial and radiogenic radionuclides (e.g. 40K, 23'8U and 232Th series), cosmic rays and cosmogenic radionuclides (e.g. 7Be), fertilizers (e.g. superphosphate), black sand (transported by the Nile River), fallout (either from nuclear testing or Chernobyl), seawater currents (transported either natural or man-made), Suez Canal (subject to receive a radioactive releasing and effluents from either nuclear power ships or submarines passing through the Canal), biological migration and sedimentary longshore movement (e.g. Anguilla anguilla), atmospheric radioactivity (e.g. 222Rn and its daughters), domestic and medical sewage (minor source, short half-life), depleted uranium dust (possibly), satellite and aircraft accident (accidental) and rarely loss of industrial radioactive source (incidentally). El-Salloum, Rashid and El-Gamil have been considered as concentrated basins for the majority of the radioisotopes. This suggestion was due to the special topographical features of these three stations, which make the accumulation of the radioactive isotopes possible. Calculations of outdoor absorbed dose rate for human population at all stations under investigation from 238U, 232Th and 40K were carried out. The calculated absorbed dose rate has been distinguished the coast into normal areas and Rashid black sand area as high background area. The range of calculated dose was 8.39-38.5 nGy/h. Good agreement was observed with NCRP absorbed dose rates 26 (17-40) nGy/h. Calculations of gamma absorbed dose rate in Rashid black sand area collected in July 1998 recorded as 0.72 ?Gy/h. This value was considered as relatively high dose rate and it is remarkable of the high background radiation area at Rashid. Comparing with the reported gamma radiation dose rates in the others high background radiation areas, it was in agreement with Ramsar in Iran (0.7-50 ?Gy/h) and relatively lower than 1-2 ?Gy/h at Guarapari, Meaipe and Cumuruxatiba in Brazil. Annual intake radiation dose was achieved by estimation of the human intake of radioactivity due to fish consumption considering the Egyptian values. Using the mathematical calculation of annual dose per Bq, the total dose to a person, daily fed with 0.0136 kg fish, in one year was 10.3 ?Sv/y, which is mainly from 40K. The only man-made radionuclide detected in the Egyptian Mediterranean coast is 137Cs with an average value 0.37 Bq/kg. This average value shows high agreement with the other referenced values in the world. The main source of 137Cs is atmospheric fallout either from nuclear testing or Chernobyl. The marine transport from western Mediterranean could be considered as another source. Surface seawater salinity showed a positive correlation with the concentrations of 40K in surface seawater (r = 0.64). A mathematical model has been deduced to estimate the range of natural 40K in surface seawater. Assessment of radioactivity bioaccumulators was made among different biota collected from the Egyptian Mediterranean coast. It revealed that, Patella spp., Anguilla spp. and Mytilus spp were the best marine organisms for the capability to accumulate 40K. Also, Patella spp., Anguilla spp. and the intermediate leaves of Posidonia spp. were found as good accumulators of both 214Pb and 214Bi. Anguilla spp. and Mytilus were found to be good accumulators of 228Ac

  1. Expression of therapeutic misconception amongst Egyptians: a qualitative pilot study

    Directory of Open Access Journals (Sweden)

    Silverman Henry J

    2009-06-01

    Full Text Available Abstract Background Studies have shown that research participants fail to appreciate the difference between research and medical care, labeling such phenomenon as a "therapeutic misconception" (TM. Since research activity involving human participants is increasing in the Middle East, qualitative research investigating aspects of TM is warranted. Our objective was to assess for the existence of therapeutic misconception amongst Egyptians. Methods Study Tool: We developed a semi-structured interview guide to elicit the knowledge, attitudes, and perspectives of Egyptians regarding medical research. Setting: We recruited individuals from the outpatient settings (public and private at Ain Shams University in Cairo, Egypt. Analysis: Interviews were taped, transcribed, and translated. We analyzed the content of the transcribed text to identify the presence of a TM, defined in one of two ways: TM1 = inaccurate beliefs about how individualized care can be compromised by the procedures in the research and TM2 = inaccurate appraisal of benefit obtained from the research study. Results Our findings showed that a majority of participants (11/15 expressed inaccurate beliefs regarding the degree with which individualized care will be maintained in the research setting (TM1 and a smaller number of participants (5/15 manifested an unreasonable belief in the likelihood of benefits to be obtained from a research study (TM2. A total of 12 of the 15 participants were judged to have expressed a TM on either one of these bases. Conclusion The presence of TM is not uncommon amongst Egyptian individuals. We recommend further qualitative studies investigating aspects of TM involving a larger sample size distinguished by different types of illnesses and socio-economic variables, as well as those who have and have not participated in clinical research.

  2. Egyptian and foreign cigarettes Pt. 2

    International Nuclear Information System (INIS)

    The concentration of 27 elements was measured using neutron activation analysis in a cigarette brand commercially manufactured in Egypt and in three foreign brands available on the Egyptian market. The cigarette components examined were tobacco, wrapping paper and ash. All results are expressed in absolute values per cigarette. The concentration of Al, As, Ba, Br, Cl, Cs, Eu, Fe, Mn, Na, Ni, Rb, Sb, Sc, Sr, Th, Ti and V in the Egyptian cigarette were above the range determined for the foreign brands examined; however, Ce, Co, Cr, Hf, K, La, Mg, Se and Zn were within that range. Except for K, Mn, Ni and Ti, the above conclusions were the same for elements determined in the ash. The wrapping paper used for the Egyptian cigarette contains the lowest quantity of Cl and Mn. (author)

  3. Composition of Egyptian nerolì oil.

    Science.gov (United States)

    Bonaccorsi, Ivana; Sciarrone, Danilo; Schipilliti, Luisa; Trozzi, Alessandra; Fakhry, Hussein A; Dugo, Giovanni

    2011-07-01

    The bitter orange flower oil (or neroli) is an essential product, largely used in perfumery. Neroli is obtained by hydrodistillation or steam distillation, from the flowers of bitter orange (Citrus aurantium L.). Since a long time neroli production is limited and its cost on the market is considerably high. The annual production in Tunisia and Morocco is ca. 1500 Kg, representing more than 90% of the worldwide production. A small amount ofneroli is also produced in Egypt, Spain and Comorros (not exceeding 150 kg totally). Due to the high cost, the producers and the users have tried to obtain less expensive products, with odor characters close to that of neroli oil to be used as substitute and sometimes as adulterants of the genuine oil. In this study are investigated five samples of Egyptian neroli oils produced in 2008 and 2009, in the same industrial plant, declared genuine by the producer. For all the samples the composition was determined by GC/FID and by GC/MS-LRI; the samples were also analyzed by esGC to determine the enantiomeric distribution of twelve volatiles and by GC-C-IRMS for the determination of the delta13C(VPDB) values of some mono and sesquiterpene hydrocarbons, alcohols and esters. The analytical procedures allowed to quantitatively determining 86 components. In particular the variation of the composition seems to be dependent on the period of production. In fact, the amount of linalool decreases from March to April while linalyl acetate presents an opposite trend, increasing in the same period. The RSD determined for the delta13C(VPDB) are very small (max. 3.89%), ensuring the authenticity of all samples. The results are also discussed in function of the limits provided by the European Pharmacopoeia (EP) (2004), AFNOR (1995) and ISO (2002) regulations for genuine neroli oils. PMID:21834247

  4. ANTHROPOMETRIC STUDY OF NASAL INDEX OF EGYPTIANS

    Directory of Open Access Journals (Sweden)

    Abdelmonem Awad Hegazy

    2014-12-01

    Full Text Available Background: The nasal index determination is one of the most commonly used anthropometric parameters in classifying human races. There are few reports in medical literature concerning nasal index that specifically address particular Egyptian populations. The objective of this study was to determine the normal parameters of external nose (width, height and nasal index in Egyptians. Methods: The study was conducted randomly on healthy Egyptian subjects of both sexes. Nasal height and width were measured using vernier caliper. Then, nasal index was determined for each subject. The obtained data were subjected to statistical analysis. Results: A total of 290 subjects, 144 males and 146 females, aged 1 month– 65 years, were enrolled in the study. The study showed the existence of sexual dimorphism in nasal morphology, appearing after the age 20 years. The mean nasal index in the investigated adults was 68.01; in males and females was 71.46 and 64.56, respectively. Conclusions: The dominant nasal type in Egyptians was in-between mesorrhine "medium" and leptorrhine "narrow" nose. Forensic and anthropological research, as well as cosmetic and reconstructive surgery may benefit from age- and sex- based data of the study.

  5. Hair-offerings: an enigmatic Egyptian custom

    Directory of Open Access Journals (Sweden)

    G. J. Tassie

    1996-11-01

    Full Text Available The Egyptians did not record the reasons that lay behind the offering of hair. Using an holistic approach, which combines both ethnographic and ethnohistoric evidence, insights may be gained into the ancient remains of these rituals and practices.

  6. Islam in Egyptian Education: Grades K-12

    Science.gov (United States)

    Neill, Charlotte M.

    2006-01-01

    This article explores the important role that the religion of Islam plays in the education of Egyptian children. The scrutiny under which the Islamic world finds itself in the after-math of September 11, 2001 has resulted in calls for educational reform, not only from the outside world, but also from the Muslim world itself. The author has a…

  7. ICT BASED TELEMEDICINE FOR THE EGYPTIAN SOCIETY

    Directory of Open Access Journals (Sweden)

    Hafez A. Fouad

    2013-12-01

    Full Text Available The One of the most challenging problems that encounter the Egyptian society is the lack of significant health care in the rural areas. This problem leads to more severe problems that face the society; the patients from the different rural areas needs to travel to the Egyptian capital where the most experienced physicians are available. This will make overhead not only on the patient budget but on the country budget since the focus on the capital makes a severe traffic problem which threaten most of the economic sectors. The telemedicine is considered one of the most important solutions that could mitigate the accumulated problems of lack of experienced physicians in the Egyptian rural areas. The application of the telemedicine encounters several challenges in Egypt; the lack in the experience in dealing with the telemedicine in these areas and the problem of insufficient medical experts that could fulfil the gab. In this paper, a new ICT-based telemedicine system is proposed to serve the Egyptian society. The portal is already released and snapshots are included

  8. Laboratory assessment of iron status and reticulocyte parameters in differential diagnosis of iron deficiency anemia and heterozygous beta-thalassemia Avaliação laboratorial do estado do ferro e parâmetros reticulocitários no diagnóstico diferencial da anemia ferropriva e beta-talassemia heterozigótica

    Directory of Open Access Journals (Sweden)

    Gisélia A.F.M. de Lima

    2002-01-01

    Full Text Available Introduction:The soluble form of transferrin receptor (sTfR has been pointed as a useful parameter to assess the iron status and erythropoiesis activity. Immature reticulocytes present high concentration of membrane transferrin receptor. We tested the correlation between sTfR and reticulocyte parameters in iron deficiency anemia (IDA and heterozygous beta-thalassemia (hetero beta-thal patients. Laboratory parameters related to iron status and reticulocytes were studied in order to establish their clinical value to distinguish both anemias. Material and Methods: Reticulocyte measurements were obtained using a semi-automated analyzer and serum concentration of sTfR was determined by an immunoenzymatic technique. Forty-nine IDA and 43 hetero beta-thal patients were studied. Results: Reticulocyte count and sTfR values were significantly higher in IDA than in hetero beta-thal group, but the best parameter to distinguish both anemias was sTfR index, obtained by the ratio sTfR/ferritin level. Transport compartment was better evaluated by transferrin dosage than by transferrin iron binding capacity (TIBC determination. The association of serum iron with transferrin measurements (transferrin index improved the accuracy of the transferrin test. Discussion: The correlation between highly immature reticulocytes and sTfR level was observed only in IDA group, suggesting that cellular iron deprivation is the main responsible factor for up regulation of the sTfR synthesis in immature red blood cells. High sTfR values in hetero beta-thal patients reflect a degree of ineffective erythropoiesis in this hemoglobinopathy. Conclusion: We concluded that sTfR, ferritin and transferrin measurements are useful and precise parameters to discriminate IDA from hetero beta-thal patients.Introdução: A forma solúvel do receptor da transferrina (sTfR tem sido indicada como um parâmetro útil na avaliação do estado do ferro e da atividade eritropoiética. Reticulócitos imaturos apresentam alta concentração dos receptores de transferrina na sua membrana. Estudamos a correlação entre sTfR e parâmetros reticulocitários em pacientes com anemia ferropriva (AF e com beta-talassemia heterozigótica (beta-tal hetero. Os parâmetros laboratoriais relacionados ao estado do ferro e reticulócitos foram estudados a fim de se estabelecer a utilidade clínica dos mesmos na distinção entre os dois tipos de anemia. Material e métodos: As medidas reticulocitárias foram obtidas usando-se um analisador hematológico semi-automático, e as concentrações de sTfR foram determinadas por técnica imunoenzimática. Foram estudados 49 pacientes com AF e 43 com beta-tal hetero. Resultados: As contagens de reticulócitos e os valores de sTfR foram significativamente mais elevados na AF do que na beta-tal hetero, mas o melhor parâmetro para diferenciar as duas anemias foi o índice de sTfR, obtido pela razão sTfR/ferritina. O compartimento de transporte foi mais bem avaliado pela dosagem de transferrina do que pela capacidade de ligação do ferro à transferrina (TIBC. A associação do ferro sérico à medida de transferrina (índice de transferrina melhorou a acurácia do teste de transferrina. Discussão: A correlação entre reticulócitos imaturos e nível de sTfR foi observada apenas no grupo com AF, sugerindo que a falta de ferro intracelular seja o principal fator responsável pelo estímulo à síntese de sTfR nas células sangüíneas imaturas. Os valores elevados de sTfR nos pacientes com beta-tal hetero refletem um certo grau de eritropoiese ineficaz nessa hemoglobinopatia. Conclusão: Concluímos que as medidas de sTfR, ferritina e transferrina são parâmetros úteis e precisos para diferenciar AF de beta-tal hetero.

  9. Studies in lexicography of Ancient Egyptian buildings and their parts

    OpenAIRE

    Spencer, P A

    1981-01-01

    The aim of this study is to attempt to clarify the meanings of the various terms used by the ancient Egyptians to describe the architectural elements which constituted an Egyptian temple. It consists of discussions of a total of fifty-seven nouns which have, in the past, been translated by general terms such as 'shrine' 'hall' 'column' and 'wall'. Each of the terms is discussed individually, and the entries are arranged-according to the order of the Egyptian alphabet. Ea...

  10. Investigating the use of Egyptian blue in Roman Egyptian portraits and panels from Tebtunis, Egypt

    Science.gov (United States)

    Ganio, Monica; Salvant, Johanna; Williams, Jane; Lee, Lynn; Cossairt, Oliver; Walton, Marc

    2015-11-01

    The use of the pigment Egyptian blue is investigated on a corpus of fifteen mummy portraits and Roman-period paintings from Tebtunis, Egypt, housed in the Phoebe A. Hearst Museum of Anthropology at the University of California, Berkeley. Egyptian blue has a strong luminescence response in the near infrared that can be exploited to created wide-field images noninvasively showing the distribution of the pigment on a work of art. A growing body of publications in the last decade highlights the increasing use of this tool and its sensitive detection limits. However, the technique is not wavelength specific. Both excitation and emission occur in a broad range. Although Egyptian blue has a strong emission in the NIR, a myriad of other compounds may emit light in this spectral region when excited in the visible. The limited number of studies including complementary analysis to verify the presence of Egyptian blue does not allow its identification on the basis of NIR luminescence alone. Through the use of in situ X-ray fluorescence and X-ray diffraction, and scanning electron microscopy/energy-dispersive spectroscopy of cross sections, this paper confirms the identification of Egyptian blue by NIR luminescence in unexpected areas, i.e., those not blue in appearance.

  11. Evaluation of genetic bases and diversity of Egyptian wheat cultivars released during the last 50 years using coefficient of parentage

    Directory of Open Access Journals (Sweden)

    Bhoja R. Basnet

    2011-04-01

    Full Text Available Discerning the genetic diversity of any crop species provides insight into the strength of an applied breeding program and directs future breeding strategies aimed at long-term genetic gain and minimized genetic vulnerability. The number and abundance of ancestral parents present in the pedigree of crop cultivars can provide an average estimation of the depth of the genetic base of the overall crop improvement program. The objectives of this study were to estimate (1 the genetic similarity among 33 Egyptian wheat (Triticum aestivum L. cultivars and different eras of release (1947-2004 and productivity groups based on COP values, and (2 the relative genetic contribution and abundance of ancestral parents from different geographical origins to the total gene pool of Egyptian wheat cultivars. Broad genetic diversity was observed among 33 Egyptian cultivars with average COP value of 0.11 and large numbers of ancestral parents (155 landraces traced to 31 countries. The genetic base ranged from very low in pre 1960’s cultivars such as ‘Giza 139’ (with only 3 landraces in the background to very high in modern cultivars such as ‘Gemmeiza-7’ (with 73 landraces in the background. ‘Hindi-62’, ‘Red Fife’, ‘Hard Red Calcutta’ and ‘Akagomughi’ were the major ancestors with 6, 5, 4, and 4% of total genetic contribution to the Egyptian wheat gene pool, respectively. Egypt, United States of America, Kenya and Ukraine were the major source countries with 16, 11, 9 and 7% of total genetic contribution to this gene pool, respectively. Though Marquis-Thatcher germplasm from North America has the greatest influence on overall Egyptian cultivars, Mexican-based sources of dwarfing and high yield, derived from ancestors such as ‘Akagomughi’ and ‘Daruma’ and exploited by the International Maize and Wheat Improvement Center (CIMMYT, were very prominent in Egyptian cultivars post 1970’s.

  12. Essential Oil Constituents of Summer Savory Plants Propagated and Adapted under Egyptian Climate

    OpenAIRE

    KHALID A. KHALID

    2016-01-01

    The essential oils obtained by water distillation from aerial parts of summer savory (Satureja hortensis L.) yielded 1.2% v/w on a dry weight. Eight constituents representing 99.7% of the S. hortensis essential oils were identified. The major constituents of S. hortensis essential oils were ?-terpinene (46.4%), carvacrol (40.2%) and ?-thujene (8.8%). The obtained constituents from S. hortensis essential oil under egyptian conditions grouped into three classes which are Monoterpene Hydrocarbo...

  13. Placentation in the Egyptian slit-faced bat Nycteris thebaica (Chiroptera: Nycteridae)

    DEFF Research Database (Denmark)

    Enders, A C; Jones, C J P; Taylor, P J; Carter, A M

    2009-01-01

    Bats are a highly successful, widely distributed group, with considerable variation in placental structure. The Egyptian slit-faced bat Nycteris thebaica is a member of one of the few families with previously undescribed placentation. It was found that, although the interhemal type of the Nycteris placenta is endotheliochorial with a single layer of cytotrophoblast, the arborizing pattern of the maternal vessels and especially the extraordinary major placental artery differs from the placenta of...

  14. Environmental isotope studies of the Egyptian Nubian sandstone aquifer of the Eastern Sahara (palaeoclimatic indications)

    International Nuclear Information System (INIS)

    A study has been made of the environmental isotopes (deuterium, oxygen-18 and carbon-14) and the hydrochemistry of the Nubian sandstone aquifer in three Egyptian oases in the Eastern Sahara. The three oases form, with the El-Kufra basin, the major regional sandstone aquifer of the eastern Sahara. Because of the interconnection among the aquifer systems, there is no sharp distinction between the isotopic compositions of shallow and deep groundwater horizons

  15. Conservation of a Rare Painted Ancient Egyptian Textile Object from the Egyptian Museum in Cairo

    Directory of Open Access Journals (Sweden)

    Yasin Zidan

    2008-01-01

    Full Text Available This study describes conservation of a painted ancientEgyptian textile object from the collection of Osiris clothsin the Egyptian Museum in Cairo, Egypt. An evaluation ofthe reactivation consolidation technique to reinforcementof ancient Egyptian painted textiles was performed.Various investigation methods were carried out to identifythe fibres, paints, and other materials, which are part ofthe selected object. The condition of the object was alsoinvestigated. Newly prepared painted linen textile sampleswere artificially deteriorated to be used for evaluation ofthe suggested reactivation consolidation technique. Theaged textile samples were treated with three selectedadhesives in three different concentrations and the sampleswere evaluated. The results show that the tested consolidationtechnique is suitable to reinforce deterioratedlinen textiles. The evaluated consolidation technique issimple, effective and can be applied using simple tools thatare common to many conservation labs.

  16. Egyptian plant species as new ozone indicators

    International Nuclear Information System (INIS)

    Of more than 30 species of plants from Egypt screened for sensitivity to ozone, four were found to be suitable for use as bioindicators. - The aim of this study was to test and select one or more highly sensitive, specific and environmentally successful Egyptian bioindicator plants for ozone (O3). For that purpose more than 30 Egyptian species and cultivars were subjected to extensive screening studies under controlled environmental and pollutant exposure conditions to mimic the Egyptian environmental conditions and O3 levels in urban and rural sites. Four plant species were found to be more sensitive to O3 than the universally used O3-bioindicator, tobacco Bel W3, under the Egyptian environmental conditions used. These plant species, jute (Corchorus olitorius c.v. local), clover (Trifolium alexandrinum L. c.v. Masry), garden rocket (Eruca sativa c.v. local) and alfalfa (Medicago sativa L. c.v. local), ranked in order of decreasing sensitivity, exhibited typical O3 injury symptoms faster and at lower O3 concentrations than Bel W3. Three variables were tested in search of a reliable tool for the diagnosis and prediction of O3 response prior to the appearance of visible foliar symptoms: pigment degradation, stomatal conductance (gs) and net photosynthetic CO2 assimilation (Pnet). Pigment degradation was found to be unreliable in predicting species sensitivity to O3. Evidence supporting stomatal conductance involvement in O3 tolerance was found only in tolerant species. A good correlation was found between gs, restriction of O3 and CO2 influx into the mesophyll tissues, and Pnet. Changes in Pnet seemed to depend largely on fluctuations in gs

  17. Body composition in Egyptian Turner syndrome girls

    Directory of Open Access Journals (Sweden)

    Moushira Erfan Zaki

    2013-01-01

    Full Text Available Objective: This cross-sectional study was undertaken to construct the new body fat % curve and provide body composition reference data for adolescent girls with Turner syndrome (TS. They diagnosed cytogenetically by blood karyotyping and not treated with growth hormone (GH. Materials and Methods: The study included 70 TS girls from age 13 years to age 17 years. Body composition was measured by bioelectrical impedance. Smoothed centile charts were derived by using the least mean square (LMS method. Results: The new body fat curves reflect the increase of body fat mass (FM from age 13 years to age 17 years. Body FM % of Egyptian TS girls was lower when compared with age-matched American untreated TS girls. Conclusion: This study presents the new body fat curves and reference values of body composition for untreated Egyptian TS adolescent girls. The present charts can be used for direct assessment of body FM % for Egyptian TS girls and evaluation for cases on GH treatment or other growth promoting therapy.

  18. Cartoons and the Egyptian Transition: A Qualitative Analysis of Egyptian Newspapers

    Directory of Open Access Journals (Sweden)

    Sara S. Elmaghraby

    2014-07-01

    Full Text Available Since the Egyptian revolution of 25 January, cartoonists have depicted the transition taking place in this country in several ways. This study aims to analyze the cartoons drawn about this transition period in Egypt in seven different Egyptian newspapers. This is done through a qualitative analysis of 80 cartoons published between 28 June and 4 July 2013, as this period saw the ousting of elected president Mohamed Morsi by the military general Abdel Fattah Al-Sisi. The study observes the different depiction of various topics, actors and visual frames used by the seven newspapers during the analyzed period, in accordance with their particular viewpoint of the transition in Egypt.

  19. Serological study on parvovirus B19 infection in multitransfused thalassemia major patients and its transmission through donor units

    Directory of Open Access Journals (Sweden)

    Kishore Janak

    2011-01-01

    Full Text Available Background: Human parvovirus B19 (B19 virus is a newly recognized agent for transfusion transmitted diseases. Beta-thalassemia major patients receive a hypertransfusion regimen, hence, are prone to acquire B19 infection; moreover, B19 escapes viral inactivation methods and donor units are not tested for B19, but there are just a couple of studies globally and none from the Asian continent. Hence, a study was designed to find the frequency of B19 infection and its transmission in multitransfused thalassemia patients. Materials and Methods: Ninety multitransfused beta-thalassemia major (thalassemia patients, 32 controls (age, sex matched without any history of transfusion were enrolled. Besides the donor units were tested in B19 un-infected patients. B19 specific IgG and IgM antibodies in the sera were analyzed by ELISA (in-house, using B19 VPI and VP2 recombinant and purified antigens; additionally HBsAg and anti-HIV and anti-HCV antibodies were tested for coexisting infections. Results: Seventy-three (81% thalassemia patients tested positive for anti-B19 IgG antibodies as compared to seven (21% in the controls group (P < 0.01, while anti-B19 IgM antibodies were detected in 37 (41.1% compared to two (6.2% in the controls (P < 0.01. Mean age of the thalassemia patient was eight years (range 2 - 18 years and B19 infection was highest in the six-to-ten year range. Seropositivity increased with the number of transfusions. Two of the four HBsAg positive and five of the seven anti-HCV IgM antibody-positive patients also had anti-B19 IgM. After a six-month follow-up, four (25% of the 16 seronegative patients seroconverted and anti-B19 IgM antibodies were detected in their donor units. Conclusions: Most of multitransfused thalassemics were B19 seropositive or had anti-B19 IgM; in the remaining uninfected group, B19 got transmitted through infected / IgM-positive donor units.

  20. A new look at old bread: ancient Egyptian baking

    Directory of Open Access Journals (Sweden)

    Delwen Samuel

    1999-11-01

    Full Text Available Despite abundant archaeological, pictorial and textual evidence of ancient Egyptian life and death, we have little detailed information about the staple diet of most of the population. Now experimental work by a postdoctoral Wellcome Research Fellow in Bioarchaeology at the Institute is revealing how the ancient Egyptians made their daily bread.

  1. Elemental Analysis of Some Egyptian Ores and Industrial Iron Samples by Neutron Activation Analysis

    International Nuclear Information System (INIS)

    In this paper the neutron activation analysis technique was applied for elemental analysis of two iron ore samples as well as a sample of a first industrial iron product. The ore samples were collected from Baharia oasis and Aswan region, while the industrial product was submitted by the Egyptian iron and steel company of Helwan. The samples were prepared for investigation by thermal neutron activation using the irradiation facilities of the first Egyptian research reactor (ETRR-1) .The gamma-ray spectra were recorded by means of the hyper pure germanium detection system. The concentration percentage values of major, minor and trace elements are presented. The long and short lived isotopes were considered. A comparative study and a discussion on the elemental concentration values are given

  2. 78 FR 69324 - Revised Medical Criteria for Evaluating Hematological Disorders

    Science.gov (United States)

    2013-11-19

    ... beta thalassemia major. In proposed section 7.00C4, we define the term ``transfusion-dependent'' as it... beta-thalassemia major in North America, Blood, Jul(104(1), 34-39 (2004) (available at: http... hematocrit or hemoglobin at these levels does not necessarily correlate with an inability to do any...

  3. SOME IMPORTANT FACTORS AFFECTING EVOLUTION OF ACTIVITY BASED COSTING (ABC SYSTEM IN EGYPTIAN MANUFACTURING FIRMS

    Directory of Open Access Journals (Sweden)

    Karim MAMDOUH ABBAS

    2014-04-01

    Full Text Available The present investigation aims to determine the factors affecting evolution of Activity Based Costing (ABC system in Egyptian case. The study used the survey method to describe and analyze these factors in some Egyptian firms. The population of the study is Egyptian manufacturing firms. Accordingly, the number of received questionnaires was 392 (23 Egyptian manufacturing firms in the first half of 2013. Finally, the study stated some influencing factors for evolution this system (ABC in Egyptian manufacturing firms.

  4. Computer tomographic investigation of ancient Egyptian mummies

    Energy Technology Data Exchange (ETDEWEB)

    Huebner, K.H.; Pahl, W.M.

    1981-08-01

    Radiological and computer tomographic examinations of Egyptian mummies have been carried out at the Institute of Anthropology and Human Genetics from 1975 to 1978. These have demonstrated the value of CT in medical archaeology. It enables one to study the soft tissues, the skin (if bandaged), the muscles and any organs retained in situ for magical or religious reason. Measurements of attenuation values indicate the materials which were used for mummifying the skin and organs. Characteristic examples are described and the early results of these examinations are discussed.

  5. Documentation of BRUSII used on Egyptian data

    DEFF Research Database (Denmark)

    Klinge Jacobsen, Henrik

    1995-01-01

    The BRUSII model and its use on Egyptian data are documented in this report. A Master Plan for wind development in Egypt is a part of the project, Demonstration and Development of Technology and Planning in the Wind Energy Sector in Egypt. The Master Plan work is has been carried out in cooperation between New and Renewable Energy Authority (NREA) in Cairo and The System Analysis Department of Risø. In the work the BRUSII model has been used to analyze the perspectives for wind development in a ...

  6. SURGICAL PROCEDURES DURING ANCIENT EGYPTIAN MUMMIFICATION

    Scientific Electronic Library Online (English)

    Bob, Brier; Ronald S., Wade.

    2001-01-01

    Full Text Available Los autores intentaron replicar el sistema de momificación egipcia en un cadáver humano actual y en un trabajo anterior, los autores publicaron sus resultados sobre el uso de natron en la momificación antigua. Este informe presenta los procedimientos quirúrgicos utilizados durante el proceso de momi [...] ficación Abstract in english The authors attempted to replicate Egyptian mummification with a human cadaver. In a previous paper, the authors reported their findings on the use of natron in ancient mummification. This paper discusses the surgical procedures used in evisceration during mummification [...

  7. Rethinking Time Allocation of Egyptian Females

    OpenAIRE

    Hendy, Rana

    2010-01-01

    The present research explores for the first time to our best knowledge the extremely biased division of labor within Egyptian households. Time activities in respect of paid and unpaid work are an important aspect of this study. The classical dichotomy of "work in the market" versus "leisure" may serve as a good approximation of the role the male plays in the production activity of the household but does gross injustice to the female since it overlooks the whole time she spends, outside the ma...

  8. The Person in an Egyptian judicial Context

    OpenAIRE

    Dupret, Baudouin

    2003-01-01

    In Egyptian law, the notion of the person is formulated in statute law, used in case-law, and practiced in what is called "law in action". It is closely associated with the concept of legal capacity and incapacity. This article concentrates on legal practices related to the person as they emerge from actual legal interactions in judicial contexts. This will lead to propose a praxiological approach to the norm, the law, and the following of a rule. Such praxiological sociology allows to observ...

  9. Electrical properties of Egyptian natural graphite

    International Nuclear Information System (INIS)

    The electrical properties of Egyptian natural graphite flakes, obtained from the graphite schists of Wadi Bent, Eastern Desert, were measured. The flakes were ground and compressed into pellets. The standard four probe dc method was used to measure the temperature dependence of the electric resistivity from room temperature down to 12 K. The transverse and longitudinal magnetoresistance were measured in the low magnetic field range at temperatures 300 K, 77 K and 12 K. The transverse magnetoresistance data was used to estimate the average mobility, assuming a simple two-band model. (author). 20 refs, 4 figs, 1 tab

  10. German-Egyptian seminar on environmental research

    International Nuclear Information System (INIS)

    Industrial development and scientific advancement have opened new frontiers of interest and challenges. Anthropogenic activities are increasingly upsetting the natural environmental balance and are at the same time shifting from local impact to global importance. Science is confronted with the challenge to answer the question of what are the consequences of anthropogenic changes to the environment and to help politics formulate countermeasures for the sake of a sustainable future. Protect results achieved within the Egyptian-German cooperation were presented to the scientific community and to the interested public and discussions on future lines of actions took place. (orig./KW)

  11. SURGICAL PROCEDURES DURING ANCIENT EGYPTIAN MUMMIFICATION

    Directory of Open Access Journals (Sweden)

    Bob Brier

    2001-01-01

    Full Text Available The authors attempted to replicate Egyptian mummification with a human cadaver. In a previous paper, the authors reported their findings on the use of natron in ancient mummification. This paper discusses the surgical procedures used in evisceration during mummificationLos autores intentaron replicar el sistema de momificación egipcia en un cadáver humano actual y en un trabajo anterior, los autores publicaron sus resultados sobre el uso de natron en la momificación antigua. Este informe presenta los procedimientos quirúrgicos utilizados durante el proceso de momificación

  12. SPECTRUM OF BETA GLOBIN GENE MUTATIONS IN EGYPTIAN CHILDREN WITH ?- THALASSEMIA

    Directory of Open Access Journals (Sweden)

    MR El-Shanshory

    2014-08-01

    Full Text Available Background: The molecular defects resulting in ?-thalassemia phenotype, in the Egyptian population show a clear heterogenic mutations pattern. PCR based techniques, including direct DNA sequencing are effective on the molecular detection and characterization of these mutations. The molecular characterization of ?-thalassemia is absolutely necessary for carrier screening, for genetic counseling, and to offer prenatal diagnosis.The aim of the work: was to evaluate the different ?-globin gene mutations in one hundred Egyptian children with ?-thalassemia. Patients and Methods: One hundred of ?-thalassemic Egyptian children, covering most Egyptian Governorates. All patients were subjected to meticulous history taking, clinical examinations, complete blood count, complete blood count, hemoglobin electrophoresis, serum ferritin and direct fluorescent DNA sequencing of ?-globin gene to detect the frequency of different mutations in studied patients. Results: The most common mutations among patients were IVS I-110(G>A 48%, IVS I-6(T>C 40%, IVS I-1(G>A19%,IVS I-5(G>C10%, IVS II-848 (C>A 9%, IVS II-745(C>G 8%, IVS II-1(G>A 7%, codon"Cd"39(C> T 4%,-87(C>G 3% and the rare mutations were: Cd37 (G>A, Cd8 (-AA, Cd29(-G, Cd5 (-CT, Cd6(-A, Cd8/9(+G, Cd 106/107(+G, Cd27(C>T, IVS II-16(G> C, Cd 28 (-C, Cap+1(A>C, -88(C>A, all of these rare mutations were present in 1%. There was considerable variation in phenotypic severity among patients resulting from interaction of different ?° and ?+mutations, 79(79% patients were thalassemia major (TM and 21(21% were thassemia intermedia (TI, without genotype phenotype association. Conclusion: Direct DNA sequencing provides insights for the frequency of different mutations in ?- thalassemic patients including rare and /or unknown ones.

  13. Applications of external PIXE to ancient Egyptian artefacts

    International Nuclear Information System (INIS)

    The external Proton Induced X-Ray Emission (PIXE) facility at Royal Melbourne Institute of Technology has been used to analyse ancient Egyptian glass samples, an Egyptian wall paint fragment and soil pigments. A 0.35 mm diameter beam of 1.6 MeV protons, extracted from the vacuum through an 8 ?m gold coated Kapton foil was used. Analysis of the spectra was carried out with the analysis package PIXAN. The analysis of two Egyptian glass samples enabled the partial determination of the colouring transition metals and the manufacturing technique, indicating them to be consistent with 'New Kingdom' glasses

  14. studies on iron availability in Egyptian soils using tracer technique

    International Nuclear Information System (INIS)

    four experiments were conducted to study the available fe in some egyptian soils, representing alluvial,, calcareous, and sandy soils, including the following:1) estimation of soil available iron using different chemical methods as well as E-value and evaluated against biological method. 2) differentiation of iron as Fe2+ and Fe2+ in some selected egyptian soils by using the modified method (charlot,1966). 3) determination of total Fe in soil using neutron activation analysis. 4) the relative importance of Fe-diffusion in egyptian soils under different treatments

  15. Nutritive Value of Irradiated Egyptian Truffles

    International Nuclear Information System (INIS)

    In this study, the nutritive value of truffles was evaluated as protein efficiency ratio (C-PER) compared with casein C-PER. of white truffle was higher than brown truffle and therefore had a better nutritional quality over the brown truffle. Egyptian truffle could be considered as a good source of protein with good essential amino acids content and high nutritive value. It was found that white and brown truffles (Al-Kamah) grow in the north westarn coast of the Egyptian desert, white truffle was identified as Tirmania nivea while brown truffle was identified as Terfezia boudieri. Rats were fed on normal diet as (basal diet) for two weeks, then they were fed on the same diet with 10% of casein (control diet), replaced by 20% of irradiated and non irradiated white and brown truffle dried samples as a protein source. The nutritive value parameters were measured at the end of the experiment, gains in body weight, daily food intake, feed conversion ratio, protein efficiency ratio were measured, biological value, the biological effect on liver kideny function serum glucose. LDL and HDL-cholesterol were investigated too

  16. Physicochemical and radiological studies on some egyptian aquatic areas

    International Nuclear Information System (INIS)

    For the purpose of estimating the radiological health and safety to the Egyptian population arises from the natural background involved with coastal areas, it is necessary to make a comprehensive study to investigate the natural radionuclides activities in this environmental ecology. The locations of such areas were chosen from those in which people spend some time (e.g. the Mediterranean and Red Sea beaches, Suez Canal in addition to the River Nile Ismailia Canal and Quaroun Lake). Water and soil samples were brought from these locations and subjected to intensive physical, chemical analysis and radiological investigations. The densities of the collected soil samples were found to fall in the region of clay densities (2.30 - 2.70 g/cm 3 ). The particle size distribution analysis, of these soil samples showed values ranging from 128 Μ m to 1303 Μ according to sample site. The collected samples are mainly silicates with variable amounts of the major cations; Ca++, Mg++, Na+, K+ with some other trace elements. For the radiological investigations 238U, 226Ra, 232Th and 40K activity concentrations were resolved by spectroscopy technique. The majority of samples examined in this work showed variable activities of the naturally occurring radionuclides with fairly low levels compared with literature values reported in other countries. The analysis and discussions of the obtained data are thoroughly performed with the use of equations to estimate the radiation doses

  17. General fire protection guidelines for Egyptian nuclear installations

    International Nuclear Information System (INIS)

    The purpose of this paper is to establish the regulatory requirements that will provide and ensure fire protection of Egyptian nuclear installations. Two or more classes of occupancy are considered to occur in the same building or structure. Fire protection measures and systems were reviewed for four of the Egyptian nuclear installations. These are Egypt's first research reactor (ET-RR-1) building and systems, hot laboratories buildings and facilities, the building including the AECL type JS-6500 industrial cobalt-60 gamma irradiator ''Egypt's Mega Gamma I'' and Egypt's second research multi-purpose reactor (MPR). A brief review is given about fire incidents in Egypt, and descriptions of the only fire reported at one of the Egyptian nuclear installations over more than 35 years of operating these installations. The study outlines the various aspects of fire protection with a view to define the relevant highlights and scope of an Egyptian guidelines. (author)

  18. Studies of natural radioactivity of some Egyptian rock phosphates

    International Nuclear Information System (INIS)

    226Ra, 235U, 232Th and 40K activity concentrations (Bq/kg) in some Egyptian phosphate samples have been measured using HPGe gamma spectrometer. Also their radium equivalent activities were calculated and discussed. (author)

  19. Application of Moessbauer spectroscopy in investigating Egyptian archaeology

    International Nuclear Information System (INIS)

    This article summarizes the results of applications of the Moessbauer spectroscopy to investigate Ancient Egyptian pottery from the periods: Ancient Egyptian (3200-525 B.C.), Greek-Roman (320 B.C.-640 A.C.) and Early Islamic (800-1000 A.C.). Many objective informations deduced about: provinance, manufacturing techniques for different domestic purposes, civilization transfer between the Arab countries, methods of colouration and applying decorating glazes, and finally dating of ancient pottery. (orig.)

  20. Coronary artery ectasia in Egyptian patients with coronary artery disease.

    OpenAIRE

    Waly, H M; Elayda, M A; V.V. Lee; el-Said, G; Reul, G J; Hall, R. J

    1997-01-01

    We conducted a retrospective study of 45 Egyptian patients with coronary artery ectasia who underwent coronary bypass grafting at our institution between 1980 and 1995. We examined the anatomic distribution and type of coronary ectasia and its association with coronary risk factors in these patients, and evaluated the severity of their coronary artery disease. We compared these findings with those from a group of 230 Egyptian patients who did not have coronary ectasia. These patients also und...

  1. Molecular Characterization of Eimeria Species Naturally Infecting Egyptian Baldi Chickens

    Science.gov (United States)

    GADELHAQ, Sahar M; ARAFA, Waleed M; ABOELHADID, Shawky M

    2015-01-01

    Background: Coccidiosis is a serious protozoal disease of poultry. The identification of Eimeria species has important implications for diagnosis and control as well as for epidemiology. The molecular characterization of Eimeria species infecting Egyptian baladi chickens was investigated. Methods: Eimeria species oocysts were harvested from intestines of naturally infected Egyptian baldi chickens. The morphometry characterization of oocysts along with COCCIMORPH software was done. The DNA was extracted initially by freezing and thawing then the prepared samples was subjected to commercial DNA kits. The DNA products were analyzed through conventional polymerase chain reaction by using amplified region (SCAR) marker. Results: The PCR results confirmed the presence of 7 Eimeria species in the examined fecal samples of Egyptian baldi breed with their specific ampilicon sizes being E. acervulina (811bp), E. brunette (626bp), E. tenella (539bp), E. maxima (272bp), E. necatrix (200bp), E. mitis (327bp) and E. praecopx (354bp). A sequencing of the two most predominant species of Eimeria was done, on E. tenella and E. máxima. Analysis of the obtained sequences revealed high identities 99% between Egyptian isolates and the reference one. Similarly, E. maxima isolated from Egyptian baldi chickens showed 98% nucleotide identities with the reference strain. Only single nucleotide substitution was observed among the Egyptian E. tenella isolates (A181G) when compared to the reference one. The Egyptian isolates acquired 4 unique mutations (A68T, C164T, G190A and C227G) in compared with the reference sequence. Conclusion: This is the first time to identify the 7 species of Eimeria from Egyptian baladi chickens. PMID:25904950

  2. Molecular characterization of eimeria species naturally infecting egyptian baldi chickens.

    Directory of Open Access Journals (Sweden)

    Sahar M Gadelhaq

    2015-03-01

    Full Text Available Coccidiosis is a serious protozoal disease of poultry. The identification of Eimeria species has important implications for diagnosis and control as well as for epidemiology. The molecular characterization of Eimeria species infecting Egyptian baladi chickens was investigated.Eimeria species oocysts were harvested from intestines of naturally infected Egyptian baldi chickens. The morphometry characterization of oocysts along with COCCIMORPH software was done. The DNA was extracted initially by freezing and thawing then the prepared samples was subjected to commercial DNA kits. The DNA products were analyzed through conventional polymerase chain reaction by using amplified region (SCAR marker.The PCR results confirmed the presence of 7 Eimeria species in the examined fecal samples of Egyptian baldi breed with their specific ampilicon sizes being E. acervulina (811bp, E. brunette (626bp, E. tenella (539bp, E. maxima (272bp, E. necatrix (200bp, E. mitis (327bp and E. praecopx (354bp. A sequencing of the two most predominant species of Eimeria was done, on E. tenella and E. máxima. Analysis of the obtained sequences revealed high identities 99% between Egyptian isolates and the reference one. Similarly, E. maxima isolated from Egyptian baldi chickens showed 98% nucleotide identities with the reference strain. Only single nucleotide substitution was observed among the Egyptian E. tenella isolates (A181G when compared to the reference one. The Egyptian isolates acquired 4 unique mutations (A68T, C164T, G190A and C227G in compared with the reference sequence.This is the first time to identify the 7 species of Eimeria from Egyptian baladi chickens.

  3. Genetic drift evolution under vaccination pressure among H5N1 Egyptian isolates

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    Afifi Manal A

    2011-06-01

    Full Text Available Background The highly pathogenic H5N1 is a major avian pathogen that intensively affects the poultry industry in Egypt even in spite of the adoption of vaccination strategy. Antigenic drift is among the strategies the influenza virus uses to escape the immune system that might develop due to the pressure of extensive vaccination. H5N1 mutates in an intensified manner and is considered a potential candidate for the possible next pandemic with all the catastrophic consequences such an eventuality will entail. Methods H5N1 was isolated from the pooled organ samples of four different affected flocks in specific pathogen free embryonated chicken eggs (SPF-ECE. A reverse transcriptase polymerase chain reaction (RT-PCR was performed to the haemagglutingin and neuraminidase. Sequencing of the full length haemagglutingin was performed. Sequence analyses of the isolated strains were performed and compared to all available H5N1 from Egyptian human and avian strains in the flu database. Changes in the different amino acid that may be related to virus virulence, receptor affinity and epitope configuration were assigned and matched with all available Egyptian strains in the flu database. Results One out of the four strains was found to be related to the B2 Egyptian lineage, 2 were related to A1 lineage and the 4th was related to A2 lineage. Comparing data obtained from the current study by other available Egyptian H5N1 sequences remarkably demonstrates that amino acid changes in the immune escape variants are remarkably restricted to a limited number of locations on the HA molecule during antigenic drift. Molecular diversity in the HA gene, in relevance to different epitopes, were not found to follow a regular trend, suggesting abrupt cumulative sequence mutations. However a number of amino acids were found to be subjected to high mutation pressure. Conclusion The current data provides a comprehensive view of HA gene evolution among H5N1 subtype viruses in Egypt. Egyptian H5N1-AIVs are constantly undergoing genetic changes and reveal a complex pattern of drifts. These findings raise the concerns about the value of using influenza vaccines in correlation with the development of antigenic drift in influenza epidemics.

  4. Radiation levels in ancient Egyptian mummies

    Energy Technology Data Exchange (ETDEWEB)

    Hussein, M.I.; Hussein, A.Z.; Barakat, M.F. [Atomic Energy Authority, Cairo (Egypt). National Center for Nuclear Safety and Radiation Control; Nakhla, S.; Iskander, N. [Egyptian Antiquities Organization (Egypt)

    1994-07-01

    Radiation levels were studied in the mummies room and some galleries in the Egyptian museum as well as in the medical museum of the Faculty of Medicine, Cairo University. ``gamma`` and {beta} radiation levels show almost background values in direct contrast to some mummies in the closed mummies room and inside the glass cases used for protection. Radon decay products in the room atmosphere and inside the glass cases enclosing some mummies show slightly higher levels than the background which were attributed to inefficient ventilation. After reasonable ventilation during the work these levels approached the normal values. High resolution {gamma}-ray spectroscopy measurements for the aerosol samples on the filters have shown background values. The results indicated that the mummies do not contain any radioactivity content or any radioactive sources as was previously suggested. (Author).

  5. Did the ancient egyptians discover Algol?

    Science.gov (United States)

    Jetsu, L.; Porceddu, S.; Porceddu, S.; Lyytinen, J.; Kajatkari, P.; Markkanen, T.; Toivari-Viitala, J.

    2013-02-01

    Fabritius discovered the first variable star, Mira, in 1596. Holwarda determined the 11 months period of Mira in 1638. Montanari discovered the next variable star, Algol, in 1669. Its period, 2.867 days, was determined by Goodricke (178). Algol was associated with demon-like creatures, "Gorgon" in ancient Greek and "ghoul" in ancient Arab mythology. This indicates that its variability was discovered much before 1669 (Wilk 1996), but this mythological evidence is ambiguous (Davis 1975). For thousands of years, the Ancient Egyptian Scribes (AES) observed stars for timekeeping in a region, where there are nearly 300 clear nights a year. We discovered a significant periodicity of 2.850 days in their calendar for lucky and unlucky days dated to 1224 BC, "the Cairo Calendar". Several astrophysical and astronomical tests supported our conclusion that this was the period of Algol three millennia ago. The "ghoulish habits" of Algol could explain this 0.017 days period increase (Battersby 2012).

  6. Radon Progeny in Egyptian Underground Phosphate Mines

    International Nuclear Information System (INIS)

    In addition to the workers in uranium mines, the staff of other underground mines, such as workers in underground phosphate mines, can be exposed to 222Rn and its progeny. In this study the individual radon progeny concentrations were measured in three Egyptian underground phosphate mines to estimate the occupational exposure of the workers at those sites. A filter method was used to measure individual radon progeny concentrations (218Po, 214Pb and 214Po). The reported mean values of radon progeny concentrations exceed the action levels which are recommended by ICRP 65 (1993). Based on the measured individual radon progeny concentrations (218Po, 214Pb and 214Po) in these mines, the annual effective dose for the workers has been calculated using the lung dose model of ICRP 66 (1994). According to the obtained results, some countermeasures were recommended in this study to minimise these exposure levels. (author)

  7. Radon progeny in Egyptian underground phosphate mines.

    Science.gov (United States)

    el-Hady, M A; Mohammed, A; el-Hussein, A; Ali, A E; Ahmed, A A

    2001-01-01

    In addition to the workers in uranium mines, the staff of other underground mines, such as workers in underground phosphate mines, can be exposed to 222Rn and its progeny. In this study the individual radon progeny concentrations were measured in three Egyptian underground phosphate mines to estimate the occupational exposure of the workers at those sites. A filter method was used to measure individual radon progeny concentrations (218Po, 214Pb and 214Po). The reported mean values of radon progeny concentrations exceed the action levels which are recommended by ICRP 65 (1993). Based on the measured individual radon progeny concentrations (218Po, 214Pb and 214Po) in these mines, the annual effective dose for the workers has been calculated using the lung dose model of ICRP 66 (1994). According to the obtained results, some countermeasures were recommended in this study to minimise these exposure levels. PMID:11468809

  8. Higher Education Externalities in Egyptian Labor Markets

    Directory of Open Access Journals (Sweden)

    Hanan Nazier

    2013-03-01

    Full Text Available Augmenting a Mincerian earnings function with governorate level data, this paper estimated the external return to higher education for individuals in Egypt in 2010. The results suggested that these externalities are negative and exist only for female workers, while for males these externalities were again negative but statistically insignificant. A unit increase in governorate average higher education is associated with a 68% decrease in females’ hourly wage. This could be explained by the fact that education degrees are simply used as a device to signal higher ability without raising productivity. Another reason could be excess supply of higher education graduates in the Egyptian labor market. These results have been tested through a number of robustness checks. Results survived to the introduction of individual and governorate level variables; it is not due to imperfect substitutability across workers; it still holds when treating local human capital as endogenous variable and instrumented it.

  9. Examination of an Egyptian mummy - stereolithography applied

    International Nuclear Information System (INIS)

    This paper describes the techniques of three dimensional imaging and stereolithography based on serial CAT-scans applied to the examination of the skull of an Egyptian mummy. Both the three dimensional image and the polymeric cast of the mummy skull presented finer details. It was confirmed that the subject was a male, approximately 30 - 35 years old. Fracturing of the ethmoid bone, e=sequelae to the removal of the brain, was observed in both types of presentations. Apart from this and signs of parodontitis, no pathology was observed. Stereolithography is a most powerful, non-destructive approach to the study of mummies. It might solve some of the problems of reburials, and further be of value in forensic medicine and paleo-ontology. (authors)

  10. Upgrading the Egyptian Scanning Land mine Detectors

    International Nuclear Information System (INIS)

    This article presents and discusses the upgrading processes which were performed to increase the detection capability of the Egyptian Scanning Land mine Detectors, ESCALAD system. The upgrading processes include different designs which were made to mount the detectors tray. These arrangements aim to overcome the effect of the soil surface roughness and stand off distance on the scanning capability. Also a more stable and reliable PCI data acquisition board with fast Digital I/O up to 125 M/s was used. Moreover, data acquisition software which uses different algorithms for background subtraction and 2D-image filtration was build and developed. The software was build using Qt-cross-platform application and other Linux based packages. Examples of images constructed from experimental measurements using the upgraded and modified software are given and discussed. The obtained displayed images show more developed improvements and reliability.

  11. Attitude of Egyptian consumer towards irradiated food

    International Nuclear Information System (INIS)

    This study aims at the evaluation of the opinion and attitude of the consumer as to what extent they accept or refuse food preservation by radiation. Also detect the method that can attract the consumers to adopt the technique and ensure the success handling of irradiated in egyptian market. One thousand and twenty two poll sheets were collected. The questionnaire was supported with simplified information about the use of atomic energy and radiation for peaceful purpose. From the results, 62.43% of the total sample size accepted the radiation technology persons that were convinced with the advantage of using irradiated food reached 70.45% . As to keep on being applied of the technology 73.97% of the total sample size agreed persons said yes to irradiated food for consumption if it is made available in the market were 57.53%

  12. Zoonotic Chicken Toxoplasmosis in Some Egyptians Governorates

    Directory of Open Access Journals (Sweden)

    Ehab Kotb El-Mahllawy

    2012-01-01

    Full Text Available Toxoplasmosis is one of the most common diseases prevalent in the world, caused by a coccidian parasite Toxoplasma gondii which infects humans, animals and birds. Poultry consider reliable human source of food in addition it is considered an intermediate host in transmission of the disease to humans. Trails of isolation of local T. gondii chicken strain through bioassay of the suspected infected chicken tissues in mice was carried out and the isolated strain was confirmed as being T. gondii using Polymerase Chain Reaction (PCR. Seroprevalence of antibodies against T. gondii in chicken sera in six Egyptian governorates were conducted by enzyme linked immune-sorbent assay (ELISA using the isolated chicken strain antigen. Moreover, comparison between the prevalence rates in different regions of the Egyptian governorates were been estimated. Isolation of local T. gondii chicken strain was accomplished from chicken tissues and confirmed by PCR technique. The total prevalence rate was 68.8% comprised of 59.5, 82.3, 67.1, 62.2, 75 and 50% in El Sharkia, El Gharbia, Kafr El sheikh, Cairo, Quena and Sohag governorates, respectively. The prevalence rates were higher among Free Range (FR (69.5% than commercial farm Chickens (C (68.5%; while, the prevalence rate was less in Upper Egypt than Lower Egypt governorates and Cairo. This study is the first was used antigen from locally isolated T. gondii chicken strain for the diagnosis of chicken toxoplasmosis. The higher seroprevalence particularly in free range chickens (house-reared refers to the public health importance of chickens as source of zoonotic toxoplasmosis to human.

  13. Zoonotic chicken toxoplasmosis in some Egyptians governorates.

    Science.gov (United States)

    Barakat, Ashraf Mohamed; Salem, Lobna Mohamed Ali; El-Newishy, Adel M Abdel-Aziz; Shaapan, Raafat Mohamed; El-Mahllawy, Ehab Kotb

    2012-09-01

    Toxoplasmosis is one of the most common diseases prevalent in the world, caused by a coccidian parasite Toxoplasma gondii which infects humans, animals and birds. Poultry consider reliable human source of food in addition it is considered an intermediate host in transmission of the disease to humans. Trails of isolation of local T. gondii chicken strain through bioassay of the suspected infected chicken tissues in mice was carried out and the isolated strain was confirmed as being T. gondii using Polymerase Chain Reaction (PCR). Seroprevalence of antibodies against T. gondii in chicken sera in six Egyptian governorates were conducted by enzyme linked immune-sorbent assay (ELISA) using the isolated chicken strain antigen. Moreover, comparison between the prevalence rates in different regions of the Egyptian governorates were been estimated. Isolation of local T. gondii chicken strain was accomplished from chicken tissues and confirmed by PCR technique. The total prevalence rate was 68.8% comprised of 59.5, 82.3, 67.1, 62.2, 75 and 50% in El Sharkia, El Gharbia, Kafr El sheikh, Cairo, Quena and Sohag governorates, respectively. The prevalence rates were higher among Free Range (FR) (69.5%) than commercial farm Chickens (C) (68.5%); while, the prevalence rate was less in Upper Egypt than Lower Egypt governorates and Cairo. This study is the first was used antigen from locally isolated T. gondii chicken strain for the diagnosis of chicken toxoplasmosis. The higher seroprevalence particularly in free range chickens (house-reared) refers to the public health importance of chickens as source of zoonotic toxoplasmosis to human. PMID:24163965

  14. Enhancement of the folate content in Egyptian pita bread

    Directory of Open Access Journals (Sweden)

    Cornelia M. Witthöft

    2012-04-01

    Full Text Available Introduction: Egypt has a high incidence of neural tube defects related to folate deficiency. One major food source for folate is pita (baladi bread, which is consumed daily. Bioprocessing (e.g. germination has been reported to increase the folate content in cereals. The aim was to produce pita bread with increased folate content using germinated wheat flour (GWF.Methods: Prior to milling the effects of germination and drying conditions on folate content in wheat grains were studied. Pita bread was baked from wheat flour substituted with different levels of GWF. The folate content in dough and bread and rheological properties of dough were determined.Results: Germination of wheat grains resulted in, depending on temperature, 3- to 4-fold higher folate content with a maximum of 61 µg/100 g DM (dry matter. The folate content in both flour and bread increased 1.5 to 4-fold depending on the level of flour replacement with GWF. Pita bread baked with 50% sieved GWF was acceptable with respect to colour and layer separation, and had a folate content of 50 µg/100 g DM compared with 30 µg/100 g DM in conventional pita bread (0% GWF.Conclusion: Using 50% GWF, pita bread with increased folate content, acceptable for the Egyptian consumer, was produced. Consumption of this bread would increase the average daily folate intake by 75 µg.

  15. Biodiversity of Bacterial Ecosystems in Traditional Egyptian Domiati Cheese▿

    Science.gov (United States)

    El-Baradei, Gaber; Delacroix-Buchet, Agnès; Ogier, Jean-Claude

    2007-01-01

    Bacterial biodiversity occurring in traditional Egyptian soft Domiati cheese was studied by PCR-temporal temperature gel electrophoresis (TTGE) and PCR-denaturing gradient gel electrophoresis (DGGE). Bands were identified using a reference species database (J.-C. Ogier et al., Appl. Environ. Microbiol. 70:5628-5643, 2004); de novo bands having nonidentified migration patterns were identified by DNA sequencing. Results reveal a novel bacterial profile and extensive bacterial biodiversity in Domiati cheeses, as reflected by the numerous bands present in TTGE and DGGE patterns. The dominant lactic acid bacteria (LAB) identified were as follows: Leuconostoc mesenteroides, Lactococcus garvieae, Aerococcus viridans, Lactobacillus versmoldensis, Pediococcus inopinatus, and Lactococcus lactis. Frequent non-LAB species included numerous coagulase-negative staphylococci, Vibrio spp., Kocuria rhizophila, Kocuria kristinae, Kocuria halotolerans, Arthrobacter spp./Brachybacterium tyrofermentans. This is the first time that the majority of these species has been identified in Domiati cheese. Nearly all the dominant and frequent bacterial species are salt tolerant, and several correspond to known marine bacteria. As Domiati cheese contains 5.4 to 9.5% NaCl, we suggest that these bacteria are likely to have an important role in the ripening process. This first systematic study of the microbial composition of Domiati cheeses reveals great biodiversity and evokes a role for marine bacteria in determining cheese type. PMID:17189434

  16. Biodiversity of bacterial ecosystems in traditional Egyptian Domiati cheese.

    Science.gov (United States)

    El-Baradei, Gaber; Delacroix-Buchet, Agnès; Ogier, Jean-Claude

    2007-02-01

    Bacterial biodiversity occurring in traditional Egyptian soft Domiati cheese was studied by PCR-temporal temperature gel electrophoresis (TTGE) and PCR-denaturing gradient gel electrophoresis (DGGE). Bands were identified using a reference species database (J.-C. Ogier et al., Appl. Environ. Microbiol. 70:5628-5643, 2004); de novo bands having nonidentified migration patterns were identified by DNA sequencing. Results reveal a novel bacterial profile and extensive bacterial biodiversity in Domiati cheeses, as reflected by the numerous bands present in TTGE and DGGE patterns. The dominant lactic acid bacteria (LAB) identified were as follows: Leuconostoc mesenteroides, Lactococcus garvieae, Aerococcus viridans, Lactobacillus versmoldensis, Pediococcus inopinatus, and Lactococcus lactis. Frequent non-LAB species included numerous coagulase-negative staphylococci, Vibrio spp., Kocuria rhizophila, Kocuria kristinae, Kocuria halotolerans, Arthrobacter spp./Brachybacterium tyrofermentans. This is the first time that the majority of these species has been identified in Domiati cheese. Nearly all the dominant and frequent bacterial species are salt tolerant, and several correspond to known marine bacteria. As Domiati cheese contains 5.4 to 9.5% NaCl, we suggest that these bacteria are likely to have an important role in the ripening process. This first systematic study of the microbial composition of Domiati cheeses reveals great biodiversity and evokes a role for marine bacteria in determining cheese type. PMID:17189434

  17. ASPECTS OF OBSTACLES FOR APPLYING ACTIVITY BASED COSTING (ABC) SYSTEM IN EGYPTIAN FIRMS

    OpenAIRE

    Petru STEFEA; Karim MAMDOUH ABBAS; Osama WAGDI WADI

    2013-01-01

    The following investigation aims to determine the aspects of obstacles for applying Activity Based Costing (ABC) system in the Egyptian case and the significant differences among the effects of such obstacles . The Study used the survey method to describe and analyze the obstacles in some Egyptian firms. The population of the study is Egyptian manufacturing firms. This survey used the number of 392 questionnaires that were used throughout the total of 23 Egyptian manufacturing firms, during t...

  18. Connecting Philosophy of Ancient Egyptians to Modern Thinking

    Directory of Open Access Journals (Sweden)

    Aminuddin Hassan

    2012-01-01

    Full Text Available Problem statement: Associating any knowledge from ancient Egyptians to modern civilization and thinking was important and had its own value. The process of understanding knowledge related to ancient Egyptians is actually based on the nature of philosophical thought. Approach: In the discussion of ancient Egypt philosophy, it is important to look at it from the perspectives of the four branches of philosophy; metaphysics, epistemology, axiology and logic. Metaphysics has two elements, which are ontology and cosmology. Arguments in ontology explain why most activities of people from the ancient Egypt involved agriculture and how they perceived their lives in the midst of this activity, this includes the concept of human creator; treatment to man and woman; and Egyptians? Gods and Goddesses. In addition, cosmology analyses the universe; everything inside and out of it, as well as what makes them stay and move. Results: Whereas, epistemology refers to how ancient Egyptians appreciated the existence of knowledge among them by considering the sources, types, categories and importance of particular knowledge that was gained in different ways. Besides, the aspects of axiology are also discussed here, especially in the ancient Egypt?s hieroglyphics. This writing discusses the level of aesthetical value posed by all these Egyptians, even at the time of about 3000 B.C. They could discuss to form pictographic as their written language. This activity lasted for thousands of years. Conclusion: Last but not the least, logic is another aspect that can be used in the discussion across metaphysics, epistemology and also axiology, for instance, the thinking of the philosophy behind Egyptians life. This writing relates the philosophy of ancient Egypt with the life of the modern world, not only in Egypt, but also in another part of the world, which exist from the impact of the philosophy of ancient Egypt. Modern views of Egyptians? thinking are often vastly based on what their people had and thought of in the ancient days.

  19. A Comprehensive Study of Egyptian Arabic. Volume Four. Lexicon Part I: Egyptian Arabic-English; Part II: English-Egyptian Arabic (A Preliminary Edition).

    Science.gov (United States)

    Abdel-Massih, Ernest T.; And Others

    This is the last of four instructional volumes designed for the intermediate-advanced student of Egyptian Arabic. The course deals with the language, culture, customs, and traditions of Egypt. The present volume constitutes a vocabulary, with word lists divided into 34 categories. High frequency vocabulary items are emphasized. (JB)

  20. Social media in the 2011 Egyptian uprising.

    Science.gov (United States)

    Brym, Robert; Godbout, Melissa; Hoffbauer, Andreas; Menard, Gabe; Zhang, Tony Huiquan

    2014-06-01

    This paper uses Gallup poll data to assess two narratives that have crystallized around the 2011 Egyptian uprising: (1) New electronic communications media constituted an important and independent cause of the protests in so far as they enhanced the capacity of demonstrators to extend protest networks, express outrage, organize events, and warn comrades of real-time threats. (2) Net of other factors, new electronic communications media played a relatively minor role in the uprising because they are low-cost, low-risk means of involvement that attract many sympathetic onlookers who are not prepared to engage in high-risk activism. Examining the independent effects of a host of factors associated with high-risk movement activism, the paper concludes that using some new electronic communications media was associated with being a demonstrator. However, grievances, structural availability, and network connections were more important than was the use of new electronic communications media in distinguishing demonstrators from sympathetic onlookers. Thus, although both narratives have some validity, they must both be qualified. PMID:24798232

  1. The Egyptian legislation for safe transportation of radioactive materials

    International Nuclear Information System (INIS)

    According to the Egyptian legislation related the safe transport of radioactive materials, a licence is required for the transport, import and or export these materials. The licence is granted, upon a written application to NCNSRC-AEA. All the procedures and conditions for granting the NCNSRC-AEA licence to handle/ transport radioactive materials/wastes have been developed according to the international and Egyptian legislation. The procedures for transit of ships carrying radioactive materials in Suez Canal are also constructed. The NCNSRC-AEA experts are entitled to accept or to refuse the transit of ships carrying radioactive materials in the Suez Canal, in the Egyptian regional waters, in the sea harbours or in the exclusive economic zones of Egypt according to the national and international regulations. (author)

  2. Overview of the Egyptian Radiation Monitoring Network and Radioactivity Levels of the Egyptian Territories

    International Nuclear Information System (INIS)

    The Chernobyl accident in 1986 arose much concern throughout the world regarding the detection of contamination, control of contaminated food, related legislation and environmental monitoring. In Egypt, the environmental radioactivity monitoring program involves the establishment of a radiation monitoring network stations for continuous monitoring of ambient gamma radiation levels in the air, water, aerosols, dust particles and conventional gas pollutants. The network consists of 42 field stations for gamma monitoring of air, 14stations for beta aerosols and 15 stations for conventional pollutants. soil samples adjacent to the stations distributed all over the Egyptian territories have been collected and analyzed by gamma spectrometry. The natural radionuclides K40, U-238 series Th-232 series and the global fallout Cs-137 are found in all the collected samples. The absorbed dose rates are calculated and presented

  3. Pictorial Metaphor in Selected Egyptian Newspapers Cartoons during the 25th of January 2011 Egyptian Revolution.

    Directory of Open Access Journals (Sweden)

    Ghada Abdel Aziz Ashmawi

    2014-03-01

    Full Text Available Metaphor is persuasive in having cognitive, emotional and aesthetic effect. It has been argued that any visual representation can be considered a metaphor if it represents a metaphoric thought. Chartris-Black’s Critical Metaphor Analysis and Forceville’s model of pictorial metaphor are both used to analyze the data under investigation. Chateris-Black’s Critical Metaphor Analysis is used based on the idea that the use of metaphors helps in conveying the underlying ideologies of the writers. Moreover, Forceville’s model of pictorial metaphor aims at investigating various types of pictorial metaphor in different genres. The political cartoons investigated in this study are drawn from three independent newspapers: Al Dastour, Al Masry Al Youm and Al Youm AL Sabea during the 25th of January 2011 Egyptian Revolution. This study aims at exploring how metaphors are expressed in the visual mode, more specifically in newspapers cartoons, tracing the use of pictorial metaphor in selected independent newspapers cartoons during the eighteen days of the 25th of January 2011 Egyptian revolution, and finally, identifying the cartoonists’ underlying ideological motivations and their attitudes to the revolution, which ultimately direct the audience’s ideology. The results of this study suggest that Chateris-Black’s Critical Metaphor Analysis can be applied not only on the textual level, but also on the semiotic and pictorial ones. In addition, metaphors are frequently used in political cartoons to evoke strong emotive effect and reinforce ideologies to achieve persuasion. Keywords: Pictorial Metaphor, Critical Metaphor Analysis, political cartoon

  4. Pragmatics of the Evil Eye in Egyptian Arabic.

    Science.gov (United States)

    Mughazy, Mustafa A.

    A study examined the different strategies used by speakers of Egyptian Arabic to ward off the potential effects of the evil eye, specifically the responding strategies to compliments perceived as invocations of evil as it relates to the gender of the recipient of the compliment and the social context in which the compliment takes place. Social…

  5. Strategic Leadership and Its Application in Egyptian Universities

    Directory of Open Access Journals (Sweden)

    Hany R. Alalfy

    2014-11-01

    Full Text Available Today's universities operate in a climate of great change, along with increased responsibilities and accountability from Internal and external customers. This has resulted in calls for a new kind of leadership working to help the university to improve educational services and face more challenges, called strategic leadership, at the university level. Aim of study defining of Egyptian leadership universities pattern of modern leadership styles, named as Strategic leadership (concept, objectives, roles, requirements, and application obstacles. Relate to the suffering of the Egyptian universities of many problems that limit their efficiency and effectiveness. This led to the need to search for new approaches as strategic leadership for eliminate of these problems. The study used a descriptive approach for its suitability for the nature of the study. The study found multiple reasons for the application of strategic leadership style in Egyptian universities as a result of  the problems the leaderships of the Egyptian universities suffer from  which limits its efficiency and effectiveness. Study recommended starting applying this pattern quickly after all the positive results it achieved in many universities.   

  6. MORPHOMETRY OF GLENOID FOSSA IN ADULT EGYPTIAN SCAPULAE

    Directory of Open Access Journals (Sweden)

    Gamal Hamed El-Sayed Hassanein

    2015-06-01

    Full Text Available Background: Knowledge of normal variations in shape and size of the glenoid fossa are required to improve efficacy and minimize failure rates in shoulder arthroplasty, particularly those involving the glenoid component of shoulder joint. Studies concerning glenoid morphometry among Egyptian population are scarce. The objective of the present study was to determine morphological types and diameters of glenoid fossa in adult Egyptian scapulae . Material and methods: A total of 68 dry adult unpaired scapulae of unknown age and sex were randomly selected. The shape and diameters of glenoid fossa in each specimen were recorded and collected data were statistically analyzed. Results : Glenoid fossa revealed a superior - inferior diameter of 3.31 ± 0.39 and 2.87 ± 0.41 centimeters and an anterior - posterior diameter of 2.44 ± 0.44 and 2.21 ± 0.44 centimeters on the right and left sides respectively. The anterior margin of glenoid fossa presented a notch in 76.47% of studied scapulae, and accordingly the fossa was classified into three morphological types; pear-shaped (45.59%, inverted comma-shaped (30.88% and oval – shaped (23.53%. Conclusion : The documented findings about glenoid fossa in the present study would help to decide the proper size of glenoid component in shoulder arthroplasty among Egyptians. Moreover, approximately one third of Egyptians are liable to Bankart lesion.

  7. Muslim Egyptian and Lebanese Students' Conceptions of Biological Evolution

    Science.gov (United States)

    BouJaoude, Saouma; Wiles, Jason R.; Asghar, Anila; Alters, Brian

    2011-01-01

    In this study, we investigated distinctions among the diversity of religious traditions represented by Lebanese and Egyptian Muslim high school students regarding their understanding and acceptance of biological evolution and how they relate the science to their religious beliefs. We explored secondary students' conceptions of evolution among…

  8. Zinc status in some Egyptian soils using tracer technique

    International Nuclear Information System (INIS)

    Three experiments were conducted to study the available Zn in the egyptian soils these were, i) evaluation of different methods for estimating available Zn. II) a proposed method using tracer technique for estimation the labile pool of Zn. III) a study for the diffusion coefficient of Zn in soils as affected by chelating agents

  9. Cultural Considerations for Evaluation Consulting in the Egyptian Context.

    Science.gov (United States)

    Seefeldt, Michael F.

    1985-01-01

    Reflecting on his experiences as an evaluation consultant at the Suez Canal University Faculty of Medicine in Egypt the author discusses: (1) implications of the Egyptian political context; (2) adapting to the host culture; and (3) maintaining distance from one's own culture. Personal qualities to complement the recommended naturalistic methods…

  10. Relations between Nutrition and Cognitive Performance in Egyptian Toddlers.

    Science.gov (United States)

    Wachs, Theodore D.; And Others

    1993-01-01

    This study assessed whether specific nutritional variables added unique variance to the prediction of toddler development outcomes in an Egyptian village, using 153 toddlers. Results suggest that, for the 18- to 23-month age, specific nutritional predictors can be identified and that there is specificity of nutritional action. (SLD)

  11. The Case for (Social) Entrepreneurship Education in Egyptian Universities

    Science.gov (United States)

    Kirby, David A.; Ibrahim, Nagwa

    2011-01-01

    Purpose: The purpose of this paper is to explore awareness of social entrepreneurship amongst Egyptian students and to determine what is needed to create more graduate social entrepreneurs. Design/methodology/approach: The theoretical framework is Ajzen's Theory of Planned Behavior. Data collection is a questionnaire survey of 183 of the 2,000…

  12. New Terpenes from the Egyptian Soft Coral Sarcophyton ehrenbergi

    OpenAIRE

    Ahmed Elkhateeb; Ahmed A. El-Beih; Gamal-Eldeen, Amira M.; Alhammady, Montaser A.; Shinji Ohta; Paré, Paul W.; Hegazy, Mohamed-Elamir F.

    2014-01-01

    Chemical investigations of the Egyptian soft coral Sarcophyton ehrenbergi have led to the isolation of compounds 1–3 as well as the previously reported marine cembranoid diterpene sarcophine (4). Structures were elucidated by comprehensive NMR and HRMS experimentation. Isolated compounds were in vitro assayed for cytotoxic activity against human hepatocarcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines.

  13. Combined Therapy with Deferiprone and Desferrioxamine as Compared to Desferasirox on Ventricular Function in Thalassemia Major Patients

    Directory of Open Access Journals (Sweden)

    Sartipzade NH

    2012-09-01

    Full Text Available AbstractBackgroundMyocardial iron overload is the leading cause of death in patients with beta-thalassemia major.Combined therapy with deferiprone(DFP and desferrioxamine (DFOwere suggested to be more effective than deferasirox(DFX for removing heart iron. Deferasirox has recently been made available but its long-term efficacy on cardiac function has not yet been established. Our study aimed to compare the effectiveness of deferiproneanddesferrioxaminewith deferasiroxon ventricular function in thalassemia major patients.Materials and MethodsIn this clinical trialstudy,72thalassemia major (TM patients were randomised to receive either deferipronecombined with desferrioxamineanddeferasirox ,and thencardiac function were evaluated. Data were analysed for left ventricular ejection fractions(LVEFat baselinebyechocardiograpy, following 12 months of treatment.Results72 TM patientswere enrolled in this study lasting 12 months,36 TMwere placed on DFP/DFO (DFP,50–86 mg/kg body weight; DFO, 24–52 mg/kg body weigh,36received DFX(range 18–40 mg/kg body weight.In 36 patients receiving combined therapy, left ventricular ejection fractionincreased from 59.3+/-5.7% to 63.7+/-5.1% (p=0.001 over 12 months [baseline LVEF values 56-61%]. deferasirox showed no change in LVEF (p = 0.93.We found improvement of left ventricular ejection fractionsin the deferiprone combined with desferrioxamine versus the deferasirox group (P = 0.008.ConclusionThe patients treated with combined therapy with deferiprone and desferrioxamineshowed better systolic ventricular function compared to the patients treated with deferasirox.The patients treated with combined therapy with deferiprone and desferrioxamine showed better systolic ventricular function compared to the patients treated with deferasirox.

  14. Placentation in the Egyptian slit-faced bat Nycteris thebaica (Chiroptera: Nycteridae)

    DEFF Research Database (Denmark)

    Enders, A C; Jones, C J P; Taylor, P J; Carter, A M

    2009-01-01

    Bats are a highly successful, widely distributed group, with considerable variation in placental structure. The Egyptian slit-faced bat Nycteris thebaica is a member of one of the few families with previously undescribed placentation. It was found that, although the interhemal type of the Nycteris...... placenta is endotheliochorial with a single layer of cytotrophoblast, the arborizing pattern of the maternal vessels and especially the extraordinary major placental artery differs from the placenta of the emballonurid bats to which this family is considered to be most closely related. The major placental...... other bat species. The paraplacenta is extensive with abundant fetal vessels underlying cytotrophoblast and syncytial trophoblast layers, fronting on an endometrium that largely lacks uterine epithelial cells but has large decidual cells and is poorly vascularized. The placenta of Nycteris lacks a...

  15. A Comprehensive Study of Egyptian Arabic. Volume Three: A Reference Grammar of Egyptian Arabic (A Preliminary Edition).

    Science.gov (United States)

    Abdel-Massih, Ernest T.; And Others

    This is the third of four instructional volumes designed for the intermediate-advanced student of Egyptian Arabic. The course deals with the language, culture, customs, and traditions of Egypt. The present volume constitutes a reference grammar, arranged alphabetically by grammatical and linguistic terms. A bibliography is appended. (JB)

  16. Evaluation of the Mechanical Durability of the Egyptian Machine Readable Booklet Passport

    Directory of Open Access Journals (Sweden)

    Ahmed Mahmoud Yosri

    2013-12-01

    Full Text Available In 2008 the first Egyptian booklet Machine Readable Passport/ MRP has been issued and its security and informative standard quality levels were proved in a research published in 2011. Here the durability profiles of the Egyptian MRP have been evaluated. Seven mechanical durability tests were applied on the Egyptian MRP. Such tests are specified in the International Civil Aviation Organization / ICAO standard requirements documents. These seven very severe durability tests resulted in that the Egyptian MRP has achieved better & higher results than the values detected in ICAO-Doc N0232: Durability of Machine Readable Passports - Version: 3.2. Hence, this research had proved the complete conformance between the Egyptian MRP mechanical durability profiles to the international requirements. The Egyptian booklet MRP doesn’t need any obligatory modification concerning its mechanical durability profiles.

  17. Evaluation of the Mechanical Durability of the Egyptian Machine Readable Booklet Passport

    OpenAIRE

    Ahmed Mahmoud Yosri

    2013-01-01

    In 2008 the first Egyptian booklet Machine Readable Passport/ MRP has been issued and its security and informative standard quality levels were proved in a research published in 2011. Here the durability profiles of the Egyptian MRP have been evaluated. Seven mechanical durability tests were applied on the Egyptian MRP. Such tests are specified in the International Civil Aviation Organization / ICAO standard requirements documents. These seven very severe durability tests resulted in that th...

  18. The implementation of world class manufacturing techniques in Egyptian manufacturing firms: An empirical study

    OpenAIRE

    Salaheldin, S.I.; Eid, R

    2007-01-01

    Purpose - The purposes of this paper are to illustrate how the world class manufacturing (WCM) techniques which could be described as outperforming the industry's global best practices have been implemented in the Egyptian manufacturing firms, to identify the critical driving and resisting forces toward WCM techniques implementation in Egyptian manufacturing firms, and to provide guidelines for the successful implementation of WCM by Egyptian manufacturers. Design/methodology/approach - The d...

  19. An investigation into the ancient Egyptian cultural influences on the Yorubas of Nigeria

    OpenAIRE

    Jock M. Agai

    2013-01-01

    There are many cultural practices that connect ancient Egyptians to the Yorubas and the new interpretation of the Oduduwa legend suggests that the Yorubas have originated or are influenced mainly by the Egyptians. The attestation of Egypt as the main influencer of the Yoruba culture made Egypt significant in the study of the history of the Yoruba people. Some writers are beginning to think that the ancient Egyptians were responsible for introducing and spreading many cultures amongst the Yoru...

  20. Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

    OpenAIRE

    M. M. Ramadan; Ali, M.M.; Ghanem, K. Z.; El-Ghorabe, A. H.

    2015-01-01

    Inhibitors of tumor growth using extracts from aromatic plants are rapidly emerging as important new drug candidates for cancer therapy. The cytotoxicity and in vitro anticancer evaluation of the essential oils from thyme, juniper and clove has been assessed against five different human cancer cell lines (liver HepG2, breast MCF-7, prostate PC3, colon HCT116 and lung A549). A GC/MS analysis revealed that ?-pinene, thymol and eugenol are the major components of Egyptian juniper, thyme and clov...

  1. Essential Oil Constituents of Summer Savory Plants Propagated and Adapted under Egyptian Climate

    Directory of Open Access Journals (Sweden)

    Khalid A. Khalid

    2016-01-01

    Full Text Available The essential oils obtained by water distillation from aerial parts of summer savory (Satureja hortensis L. yielded 1.2% v/w on a dry weight. Eight constituents representing 99.7% of the S. hortensis essential oils were identified. The major constituents of S. hortensis essential oils were ?-terpinene (46.4%, carvacrol (40.2% and ?-thujene (8.8%. The obtained constituents from S. hortensis essential oil under egyptian conditions grouped into three classes which are Monoterpene Hydrocarbons (MH, Oxygenated Monoterpenes (OM and Sesquiterpene Hydrocarbons (SH. It is evident that the MH reached its highest concentrations (57.8% followed by OM (41.3% in essential oil compared with the minor chemical class (SH (0.6%.

  2. Evaluation of Diet Quality of Egyptian Children and Adolescents using Healthy Eating Index

    Directory of Open Access Journals (Sweden)

    Mervat A. Esmail ­ Wafaa M.A.Saleh ­Nebal A.R.Aboul Ella ­ Asmaa M. Abd

    2009-12-01

    Full Text Available Background: Healthful eating is essential for development and well-being. Some dietary patterns are associated with 4 of the 10 leading causes of death (coronary heart disease, certain types of cancer, stroke, and type 2 diabetes. Major improvements in the health of the public can, therefore, be made by improving people's dietary patterns. The U.S. department of Agriculture has developed an index, called the Healthy Eating Index (HEI that was updated in the year 2002. It is based on different aspects of a healthful diet; the Index is designed to provide a measure of overall dietary quality, and the compliance with specific Dietary Guidelines recommendations. The aim of our study is to use the healthy eating index to assess the diet quality of a representative sample of the Egyptian children and adolescents and to examine the association between body mass index and caloric intake of the studied sample. Materials & Methods: This study is a part of National Egyptian survey, Diet, Nutrition and Prevention of Chronic Non-communicable Diseases. The Healthy Eating Index was applied with slight modifications to measure how well the studied Egyptian students' diet conforms to recommended healthy eating pattern. The data were based on representative sample (2145 of children and adolescents (10 -18 years in 7 governorates from. One day of dietary intake data (24 hours recall was collected, during an in-person interview. The Healthy Eating Index measures how well the studied children and adolescents' diets conform to the American Dietary Guidelines recommendations and the Food Guide Pyramid applied in our country. Ten dietary components have been identified and the overall Index has a total possible score ranging from zero to 100. Results: Our results showed that the average Healthy Eating Index score was 59.1 out of a possible 100 and it ranged from 20 to 86, Only 0.5 percent of the students had Healthy Eating scores above 80; while 16.9 percent of them received scores below 50 and the majority (82.5 percent had scores on the Healthy Eating Index between 51 and 80. In an effort to provide a "rating" of the overall student's diet, a grading scale was developed, the majority of students had diets rated as "Needs Improvement", only 0.5 % received diets rated as "Good" and 16.9 % had diets rated as "Poor". Males achieved a slightly higher average Index than females (59.7 Vs 58.2. The average score for food groups is much lower than that for dietary guidelines (23.5 Vs 35.6 out of total score of 50 for each. There was a significant positive correlation of BMI with caloric intake for male adolescents while, for females the correlation was insignificant and negative. More than 80 percent of the sample achieved the recommendations of the American Dietary Guidelines for total fat and cholesterol. Less than two-thirds of the students met the recommendations for saturated fat, Almost 30 percent of the students had the maximum score for sodium. Only 1.0 percent of them received a score of 10 for fibers. Conclusion: the majority of Egyptian children and adolescent' eating patterns, as measured by the HEI, need improvement. The results of the Index are useful in targeting nutrition education and health promotion activities, as it is a single summary measure of diet quality that can be used to monitor changes in food consumption patterns over time. A Food Quality System based on nutrient density can be one tool that can facilitate more healthful food purchases and dietary patterns.

  3. The Egyptian Revolution: First Impressions from the Field

    Directory of Open Access Journals (Sweden)

    Mohammed A. Bamyeh

    2011-02-01

    Full Text Available Never has a revolution that seemed so lacking in prospects gathered momentum so quickly and so unexpectedly. The Egyptian Revolution, starting on January 25, lacked leadership and possessed little organization; its defining events, on Friday, January 28, occurred on a day when all communication technologies, including all internet and phones, were barred; it took place in a large country known for sedate political life, a very long legacy of authoritarian continuity, and an enviable repressive apparatus consisting of more than 2 million members. But on that day, the regime of Hosni Mubarak, entrenched for 30 years and seemingly eternal, the only regime that the vast majority of the protesters had ever known, evaporated in one day.Though the regime struggled for two more weeks, practically little government existed during that period. All ministries and government offices have been closed, and almost all police headquarters were burned down on January 28. Except for the army, all security personnel disappeared, and a week after the uprising, only a few police officers ventured out again. Popular committees have since taken over security in the neighborhoods. I saw patriotism expressed everywhere as collective pride in the realization that people who did not know each other could act together, intentionally and with a purpose. During the ensuing week and a half, millions converged on the streets almost everywhere in Egypt, and one could empirically see how noble ethics—community and solidarity, care for others, respect for the dignity of all, feeling of personal responsibility for everyone—emerge precisely out of the disappearance of government.Undoubtedly this revolution, which is continuing to unfold, will be the formative event in the lives of the millions of youth who spearheaded it in Egypt, and perhaps also the many more millions of youth who followed it throughout the Arab world. It is clear that it is providing a new generation with a grand spectacle of the type that had shaped the political consciousness of every generation before them in modern Arab history. All those common formative experiences of past generations were also grand national moments: whether catastrophic defeats or triumphs against colonial powers or allies.

  4. Egyptian Activism against Female Genital Cutting as Catachrestic Claiming

    Directory of Open Access Journals (Sweden)

    An Van Raemdonck

    2013-08-01

    Full Text Available This paper deals with questions of the politics of location in knowledge and norm production within the context of Egyptian feminist activism for abandoning female genital cutting practices. It seeks to determine underlying schemes of international campaigning discourse and analyzes how these predicate and complicate Egyptian postcolonial activism. It draws on a broad literature study in addition to fieldwork in Cairo consisting of in-depth interviews with activists and policy makers. My focus is on the national Task Force against FGM from 1994 until 1999 and its subsequent cooptation by the National Council of Childhood and Motherhood. I argue through the concept of catachresis that location matters in setting the terms of anti-FGC discourse and its relation to religion.

  5. Determination of Wax Content in Egyptian Crude Oils

    OpenAIRE

    Prof.Dr.Ramadan Abu El-Ella; Dr.Ehssan Nassef

    2014-01-01

    Wax precipitation is one of the most important flow assurance problems. Unfortunately, experimental data are very scarce to confirm existing models for prediction of such production impairment and other hazardous risk; while its curative approaches and production losses add to colossal economic sabotage to the petroleum industry. The present work deals with studying the determination of wax in Egyptian crude oil by gravimetric determination precipitation with lowering temperature of the crude...

  6. Incidence and characterization of bacillus cereus isolated From egyptian foods.

    OpenAIRE

    Saleh, Y. E. [???? ????? ????

    1993-01-01

    In this study, 178 strains of Bacillus cereus were isolated from different Egyptian foods. Isolation was performed, using MYP and PEMBA media and confirmed by staining and biochemical tests. B. cereus occurred in 98% of test minced meat, 60% of sausage, 48% of rice grains, 44% of Koshari or ice-cream and 36% of pasteurized milk samples. The characteristics of these B. cereus isolates in terms of biochemical reactions, antibiotic susceptibility, pathogenicity and toxigenicity were studied. ...

  7. Sesame seed sensitization in a group of atopic Egyptian children.

    OpenAIRE

    Samar Ahmad; Dina Soliman; Dalia El-Ghoneimy; Elham Hossny

    2013-01-01

    Background: There are no published data on the prevalence of sesame allergy/sensitization in Egypt. Objective: In this pilot study, we thought to estimate the frequency of sesame seed sensitization in a group of atopic Egyptian infants and children. Methods: We consecutively enrolled 90 patients with physician diagnosed allergic disease. The study measurements included clinical evaluation for the site and duration of allergy, history suggestive of sesame seed allergy, and family history of al...

  8. What kind of Arabic and why? Language in Egyptian blogs

    OpenAIRE

    Ramsay, Gail

    2013-01-01

    This article strives to set in motion comprehensive research on the ways in which Arabic is evolving in Arabic blogs and computer mediated communication (CMC). By combining media studies, sociolinguistics and literature it examines code choice, content and mode of representation in five top ranked Egyptian blogs. We distinguish between MSA, ECA and mixed varieties and establish that all three codes may be employed. We argue that bloggers make deliberate choices regarding code, and that code-s...

  9. Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C

    OpenAIRE

    Abdel-Rahman El-Zayadi; Rizk, Hanan H.; El-Mesallamy, Hala O.; Hamdy, Nadia M.

    2011-01-01

    Objective. Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation. The present study was conducted to evaluate blood apelin level changes among 73 chronic hepatitis C (CHC) Egyptian patients and if associated with body mass index (BMI), IR, and tumor necrosis factor-alpha...

  10. Does Facebook Matter in Egyptian Graduate Environment? A Marketing Perspective

    OpenAIRE

    Ahmad Yahia Ebeid

    2012-01-01

    The current study is exploratory, and it aims at uncovering the potential role of Facebook in Egyptian university environment. The research based on 127 questionnaires. It was found that; 42% of the respondents use Facebook for educational purpose; around 85% use Facebook to be in touch with their teachers; more than 75% use Facebook to contact the faculty administration; more than 70% of students are convinced that they have added value when using Facebook in the educational context. These r...

  11. The Egyptian Revolution: First Impressions from the Field

    OpenAIRE

    Mohammed A. Bamyeh

    2011-01-01

    Never has a revolution that seemed so lacking in prospects gathered momentum so quickly and so unexpectedly. The Egyptian Revolution, starting on January 25, lacked leadership and possessed little organization; its defining events, on Friday, January 28, occurred on a day when all communication technologies, including all internet and phones, were barred; it took place in a large country known for sedate political life, a very long legacy of authoritarian continuity, and an enviable repressiv...

  12. Biodiversity of Bacterial Ecosystems in Traditional Egyptian Domiati Cheese▿

    OpenAIRE

    El-Baradei, Gaber; Delacroix-Buchet, Agnès; Ogier, Jean-Claude

    2006-01-01

    Bacterial biodiversity occurring in traditional Egyptian soft Domiati cheese was studied by PCR-temporal temperature gel electrophoresis (TTGE) and PCR-denaturing gradient gel electrophoresis (DGGE). Bands were identified using a reference species database (J.-C. Ogier et al., Appl. Environ. Microbiol. 70:5628-5643, 2004); de novo bands having nonidentified migration patterns were identified by DNA sequencing. Results reveal a novel bacterial profile and extensive bacterial biodiversity in Do...

  13. Pollen Morphology of Egyptian Malvaceae: An Assessment of Taxonomic Value

    OpenAIRE

    NAGGAR, Salah M. EL

    2004-01-01

    The pollen morphological characteristics of 21 species of Egyptian Malvaceae belonging to 10 genera: Abelmoschus Medik., Hibiscus L., Gossypium L., Lagunaria L., Abutilon Mill., Sida L., Malva L., Lavatera L., Alcea L. and Malvaviscus Cav., were investigated by light and scanning electron microscopy. The pollens were examined and described in each genus. The results demonstrated that pollen morphological characteristics, principally pollen shape, size, aperture characters and exine sculpture ...

  14. Expression of therapeutic misconception amongst Egyptians: a qualitative pilot study

    OpenAIRE

    Silverman Henry J; Khalil Susan S; Wazaify Mayyada

    2009-01-01

    Abstract Background Studies have shown that research participants fail to appreciate the difference between research and medical care, labeling such phenomenon as a "therapeutic misconception" (TM). Since research activity involving human participants is increasing in the Middle East, qualitative research investigating aspects of TM is warranted. Our objective was to assess for the existence of therapeutic misconception amongst Egyptians. Methods Study Tool: We developed a semi-structured int...

  15. Determinants of Work Relation Perception: Organizational Culture in Egyptian Workplaces

    OpenAIRE

    Mohamed Taha Mohamed

    2013-01-01

    This study aimed at investigating different types of organizational cultures common in Egyptian workplaces andhow they might be influenced by the type of ownership (governmental, public, or private), the region in whichthe organization exists (Cairo, North Egypt, or South Egypt), and the organization size (large vs. small).Organizational cultures were divided, according to the Competing Values Model proposed Cameron and Quinn(1999/2006), into four types: Market, Hierarchy, Adhocracy, and Clan...

  16. Nile Crossings: Hospitality and Revenge in Egyptian Rural Narratives

    OpenAIRE

    Granara, William E.

    2010-01-01

    This essay looks at acts of hospitality and revenge as constituent elements of a broad social code in rural Egyptian narratives. By looking at five stories in particular, I argue that hospitality and revenge work in complementarity, and that they often trespass and blur each other’s social and literary borders, creating ambiguity and complexity in the stories. The traditional rules that govern hospitality are at times challenged or inverted by hostile intentions, and revenge may be exacted fo...

  17. Barriers to E-Commerce Adoption in Egyptian SMEs

    OpenAIRE

    Abdel Nasser H. Zaied

    2012-01-01

    E-commerce has been predicted to be a new driver of economic growth for developing countries. The SME sector plays a significant role in its contribution to the national economy in terms of the wealth created and the number of people employed. Small and Medium Enterprises (SMEs) in Egypt represent the greatest share of the productive units of the Egyptian economy and the current national policy directions address ways and means of developing the capacities of SMEs. Many factors could be resp...

  18. Physical Deterioration of Egyptian Limestone Affected by Saline Water

    OpenAIRE

    Mohammed EL-GOHARY

    2013-01-01

    This study is the second in a series of experiments that describe the chemical, physical and thermal properties of archaeological limestone affected by salt and saline water in Egypt. This research aims to study the aggressive physical effects of different types of salts dominated in saline water and their different mechanisms on the acceleration of weathering processes that affect Egyptian limestone. It presents a multidisciplinary approach to characterize, at both micro/macro scales, the be...

  19. Imported inputs and Egyptian exports: Exploring the links

    OpenAIRE

    Parra, María Dolores; Martínez-Zarzoso, Inmaculada

    2015-01-01

    This paper is the first to explore the links between exporting and importing activities of Egyptian firms using panel data over the period from 2003 to 2007. The main aim is twofold. Firstly, the authors report regression results indicating that firms that both export and import are the most productive, followed by importing-, exporting-only firms and nontraders. Secondly, the authors estimate the determinants of the extensive and intensive margins of exports and imports using dynamic panel-P...

  20. Electrophoretic Characterization and the Relationship Between Some Egyptian Cruciferae

    OpenAIRE

    E.A. Kamel; H. Z. Hassan; Ahmed, S M

    2003-01-01

    The present study was carried out on 17 Egyptian taxa of the Cruciferae representing 10 genera and 13 species collected from different localities. Polyacrylamide gel electrophoresis (SDS-PAGE) was employed to characterize those taxa. The data obtained were analyzed by the NTsys-pc program package using the UPGMA clustering method. The produced dendrogram from SDS-PAGE analysis showed a close affinity and the monophyllay among the species of t...

  1. On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure

    Directory of Open Access Journals (Sweden)

    Carpenter JP

    2011-09-01

    Full Text Available Abstract Background Trials of iron chelator regimens have increased the treatment options for cardiac siderosis in beta-thalassemia major (TM patients. Treatment effects with improved left ventricular (LV ejection fraction (EF have been observed in patients without overt heart failure, but it is unclear whether these changes are clinically meaningful. Methods This retrospective study of a UK database of TM patients modelled the change in EF between serial scans measured by cardiovascular magnetic resonance (CMR to the relative risk (RR of future development of heart failure over 1 year. Patients were divided into 2 strata by baseline LVEF of 56-62% (below normal for TM and 63-70% (lower half of the normal range for TM. Results A total of 315 patients with 754 CMR scans were analyzed. A 1% absolute increase in EF from baseline was associated with a statistically significant reduction in the risk of future development of heart failure for both the lower EF stratum (EF 56-62%, RR 0.818, p Conclusion These data show that during treatment with iron chelators for cardiac siderosis, small increases in LVEF in TM patients are associated with a significantly reduced risk of the development of heart failure. Thus the iron chelator induced improvements in LVEF of 2.6% to 3.1% that have been observed in randomized controlled trials, are associated with risk reductions of 25.5% to 46.4% for the development of heart failure over 12 months, which is clinically meaningful. In cardiac iron overload, heart mitochondrial dysfunction and its relief by iron chelation may underlie the changes in LV function.

  2. The Media and the Making of the 2011 Egyptian Revolution

    Directory of Open Access Journals (Sweden)

    Amr Osman

    2012-05-01

    Full Text Available While views may differ on the factors that made the 2011 Egyptian revolution possible, the role of mass media will remain undisputable. The Internet-based social networks caught the Mubarak regime by surprise, and the popular disillusionment with the ‘national’ media led the public to turn to private newspapers and satellite channels for keeping pace with the events. This paper examines the role of specific media during the 18 days of the 2011 Egyptian revolution – from 25 January to 11 February, 2011 – which we have divided into four parts. It discusses how these media contributed to the unfolding of events, conceptualized the protests and the demands of the public, and presented the actors that participated in or opposed the revolution. These points are addressed by discussing the content of the Facebook pages of the Sixth of April Movement and We Are All Khalid Said, as well as that of a private Egyptian newspaper, al-Shuruq, and the state-run newspaper al-Ahram.

  3. Did the ancient Egyptians migrate to ancient Nigeria?

    Directory of Open Access Journals (Sweden)

    Jock M. Agai

    2014-07-01

    Full Text Available Literatures concerning the history of West African peoples published from 1900 to 1970 debate the possible migrations of the Egyptians into West Africa. Writers like Samuel Johnson and Lucas Olumide believe that the ancient Egyptians penetrated through ancient Nigeria but Leo Frobenius and Geoffrey Parrinder frowned at this opinion. Using the works of these early 20th century writers of West African history together with a Yoruba legend which teaches about the origin of their earliest ancestor(s, this researcher investigates the theories that the ancient Egyptians had contact with the ancient Nigerians and particularly with the Yorubas. Intradisciplinary and/or interdisciplinary implications: There is an existing ideology amongst the Yorubas and other writers of Yoruba history that the original ancestors of the Yorubas originated in ancient Egypt hence there was migration between Egypt and Yorubaland. This researcher contends that even if there was migration between Egypt and Nigeria, such migration did not take place during the predynastic and dynastic period as speculated by some scholars. The subject is open for further research.

  4. Physical inactivity among Egyptian and Saudi medical students

    Directory of Open Access Journals (Sweden)

    Abdel-Hady El-Gilany

    2011-02-01

    Full Text Available Objectives: Medical students, the future doctors, were presumed to be knowledgeable about physical activity and would have future influence on their patients. This study aims to describe the pattern of physical activity, predictors of physical inactivity and perceived barriers to and benefits of physical activity among a sample of Egyptian and Saudi medical students. Methods: A cross-sectional comparative study was carried out on 319 Egyptian and 297 Saudi medical students. The long form of the international physical activity questionnaire (IPAQ was used to measure physical activity. Data was analyzed according to the guidelines for data processing and analysis of the IPAQ. Perceived barriers to and potential benefits of physical activity were reported. Results: Physical inactivity was significantly higher among Saudi than Egyptian medical students (41.1% versus 15.4%, respectively. Logistic regression analysis revealed that the independent predictors of physical inactivity were non-membership in sports clubs (OR =4.6 and use of private cars for transportation (OR=3.9. The most frequent barriers to physical activity are time limitation due to busy study schedule and lack of accessible and suitable sporting places. More than 70% of students perceived that physical activity promotes and maintains health. Conclusions: Because time and access are key barriers to medical student exercise, we believe that provision of free playgrounds in the college to practice sports during free times will promote physical activity in students. [TAF Prev Med Bull 2011; 10(1.000: 35-44

  5. The impact on the Netherlands of the Egyptian greenhouse vegetable chain

    OpenAIRE

    Wijnands, J.H.M.

    2004-01-01

    This report forms part of a broader analysis of the competitiveness of Dutch tomatoes, cucumbers and peppers on the European market. It describes elements of Porter's competitiveness analysis for the Egyptian horticultural sector. Within this framework, it presents an analysis of the domestic demand, the supply, the structure and strategy of firms, the network and the Egyptian government. It concludes with a SWOT analysis.

  6. The Acquisition of an Egyptian Phonological Variant by U.S. Students in Cairo

    Science.gov (United States)

    Raish, Michael

    2015-01-01

    This study investigated the acquisition of an Egyptian phonological variant by student participants in a study abroad program at The American University in Cairo. Participants completed pre- and post-study abroad Simulated Oral Proficiency Interviews (SOPIs). The SOPI data showed a move toward an Egyptian realization of the phonological variable…

  7. Molecular seasonal, age and gender distributions of Cryptosporidium in diarrhoeic Egyptians: distinct endemicity.

    Science.gov (United States)

    El-Badry, A A; Al-Antably, A S A; Hassan, M A; Hanafy, N A; Abu-Sarea, E Y

    2015-12-01

    Cryptosporidiosis is a worldwide gastrointestinal disease caused by the protozoan Cryptosporidium parasite. It has a broad range of seasonal and age-related prevalence. We aimed to study the molecular prevalence and seasonality of Cryptosporidium over a period of 1 year in a cohort of Egyptian diarrhoeic patients. Stool samples were collected from 865 diarrhoeic patients attending outpatient clinics of Cairo University hospitals, from all age groups over a 12-month period, examined microscopically for faecal Cryptosporidium oocysts by the acid-fast staining method and for copro-DNA detection using nested polymerase chain reaction (nPCR) assays. PCR-positive samples were characterised molecularly by nPCR-restriction fragment length polymorphism (RFLP) to determine Cryptosporidium genotypes. Cryptosporidium copro-DNA was detected in 19.5 % of the collected samples throughout the year, with a major peak in summer (August) and a small rise in spring (April). Infection was mainly C. hominis (95.8 %) followed by C. parvum (3.0 %), affecting all age groups, with predominance in the pre-school age group, and decrease with age. There were statistically significant associations between the detection of Cryptosporidium and season, diarrhoea, patient age and drinking water, while gender, contact with animals and presence of mucus in stool showed no association. Cryptosporidium in diarrhoeic Egyptians was of distinct endemicity, with the bi-model mostly influenced by population dynamics, with a clear high prevalence in pre-school children and predominating anthroponotic (C. hominis) transmission throughout the year. The obtained results highlight Cryptosporidium as a water contaminant and an important cause of health problems in Egypt, necessitating further studies of the risk factors. PMID:26440040

  8. Interferon therapy shifts natural killer subsets among egyptian patients with chronic hepatitis C

    Scientific Electronic Library Online (English)

    Amal, Fathy; Mohamed Mohy, Eldin; Lobna, Metwally; Mohamed, Eida; Marwa, Abdel-Rehim; Gamal, Esmat.

    2010-08-01

    Full Text Available Natural killer cells can be divided into five subpopulations based on the relative expression of CD16 and CD56 markers. The majority of natural killer cells are CD56dim, which are considered to be the main cytotoxic effectors. A minority of the natural killer cells are CD56bright, and function as an [...] important source of immune-regulatory cytokines. Shifts of these subsets have been reported in patients with chronic hepatitis C virus infection. We sought to investigate the shift of natural killer subsets among Egyptian patients with chronic HCV and to analyze the influence of interferon therapy on this shift. We applied a flow cytometric analysis of peripheral blood natural killer subsets for 12 interferon-untreated and 12 interferon-treated patients with chronic HCV, in comparison to 10 control subjects. Among interferon-untreated patients, there was a significant reduction of CD56-16+ (immature natural killer) cells. Among interferon-treated patients, the absolute count of natural killer cells was reduced, with expansion of the CD56bright subset and reduction of the CD56dim16+ subset. Natural killer subset counts were not significantly correlated to HCV viral load and were not significantly different among interferon responders and non-responders. In conclusion, HCV infection in Egyptian patients has been observed to be statistically and significantly associated with reduction of the CD56-16+NK subset, while a statistically significant expansion of CD56bright and reduction of CD56dim16+ subsets were observed after interferon therapy. Further studies are required to delineate the molecular basis of interferon-induced shift of natural killer subsets among patients with HCV.

  9. ASPECTS OF OBSTACLES FOR APPLYING ACTIVITY BASED COSTING (ABC SYSTEM IN EGYPTIAN FIRMS

    Directory of Open Access Journals (Sweden)

    Petru STEFEA

    2013-10-01

    Full Text Available The following investigation aims to determine the aspects of obstacles for applying Activity Based Costing (ABC system in the Egyptian case and the significant differences among the effects of such obstacles . The Study used the survey method to describe and analyze the obstacles in some Egyptian firms. The population of the study is Egyptian manufacturing firms. This survey used the number of 392 questionnaires that were used throughout the total of 23 Egyptian manufacturing firms, during the first half of 2013. Finally, the study found some influencing obstacles for applying this system (ABC and there were significant differences among the aspects of obstacles for applying ABC system in the Egyptian manufacturing firms.

  10. Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia

    Directory of Open Access Journals (Sweden)

    Capretto L

    2012-01-01

    Full Text Available Lorenzo Capretto1, Stefania Mazzitelli2, Eleonora Brognara2, Ilaria Lampronti2, Dario Carugo1, Martyn Hill1, Xunli Zhang1, Roberto Gambari2, Claudio Nastruzzi31Engineering Sciences, University of Southampton, Southampton, UK; 2Department of Biochemistry and Molecular Biology, 3Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, ItalyAbstract: This report shows that the DNA-binding drug, mithramycin, can be efficiently encapsulated in polymeric micelles (PM-MTH, based on Pluronic® block copolymers, by a new microfluidic approach. The effect of different production parameters has been investigated for their effect on PM-MTH characteristics. The compared analysis of PM-MTH produced by microfluidic and conventional bulk mixing procedures revealed that microfluidics provides a useful platform for the production of PM-MTH with improved controllability, reproducibility, smaller size, and polydispersity. Finally, an investigation of the effects of PM-MTH, produced by microfluidic and conventional bulk mixing procedures, on the erythroid differentiation of both human erythroleukemia and human erythroid precursor cells is reported. It is demonstrated that PM-MTH exhibited a slightly lower toxicity and more pronounced differentiative activity when compared to the free drug. In addition, PM-MTH were able to upregulate preferentially ?-globin messenger ribonucleic acid production and to increase fetal hemoglobin (HbF accumulation, the percentage of HbF-containing cells, and their HbF content without stimulating ?-globin gene expression, which is responsible for the clinical symptoms of ß-thalassemia. These results represent an important first step toward a potential clinical application, since an increase in HbF could alleviate the symptoms underlying ß-thalassemia and sickle cell anemia. In conclusion, this report suggests that PM-MTH produced by microfluidic approach warrants further evaluation as a potential therapeutic protocol for ß-thalassemia.Keywords: microfluidics, lab-on-a-chip, design of experiments, erythroid differentiation, human erythroid precursor cells

  11. Prevalence of renal tubular dysfunction in beta thalassemia minor in shiraz

    Directory of Open Access Journals (Sweden)

    Ali Moradi Nakhodcheri

    2012-02-01

    Full Text Available  Background & objective: ?-Thalassemia minor is an asymptomatic hereditary disease. The first study on the relation of renal tubular dysfunction and ?-thalassemia minor was performed in 2002 but those studies seem inadequate.The main goal of this study is through evaluation of renal tubular function in 100 patients with thalassemia minor. Materials & Methods: 100 patients with ?- thalassemia which confirmed by hemoglobin electrophoresis and CBC as well as RBC indices were studied.14 out of 100 cases exit because of Urinary Tract Infection, diabetes mellitus or hypertension.Complete chemistry profile was performed on serum and urine of all reminder 86 patients (46 female and 40 male. Patients classified into two groups: ?-thalassemia minor with anemia and without anemia. Another control group include 50 healthy individuals also considered.Then data analyzed by proper statistical methods. Results: 20 out of 86 reminder cases e.g. 24% showed at least one index of renal tubular dysfunction.58% of patients was been anemic and 42% non anemic. The most prominent tubular dysfunction was seen in a 29 years old lady with glucosuria and without anemia. conclusion: ?-Thalassemia minor is common in Iran specially in Fars province. This study revealed significant renal tubular dysfunction in patient with ?-thalassemia minor. So it is necessary to check out thalassemic patients for renal function tests periodically. Key words: ?-thalassemia, minor,renal tubular dysfunction

  12. Phenotypic expression of hemoglobin A2 in beta-thalassemia trait with iron deficiency.

    Science.gov (United States)

    Madan, N; Sikka, M; Sharma, S; Rusia, U

    1998-09-01

    Iron status was estimated in 463 heterozygous beta-thalassemics to delineate the effect of iron deficiency on the expression of hemoglobin A2 (HbA2) in these patients. One hundred and twenty-six (27.2%) patients with the trait were iron deficient. These iron-deficient patients had a significantly (p 3.5%) in all but one heterozygote investigated. Mean HbA2/cell was significantly (p < 0.05) lower in BTT patients with iron deficiency than in patients without iron deficiency. The presence of iron deficiency did not preclude the detection of BTT in this population. The effect of iron deficiency in BTT was apparent as a significant lowering of the Hb concentration and an increased prevalence of anemia. Iron therapy is warranted for BTT patients with iron-deficiency traits and would help to significantly raise their Hb concentration. The elevation of HbA2 was striking and could be used with reliability in making the diagnosis of BTT even in the presence of iron deficiency. PMID:9797076

  13. Prevalence of anti-HAV antibodies in multitransfused patients with beta-thalassemia

    Directory of Open Access Journals (Sweden)

    Dimitrios Siagris, Alexandra Kouraklis-Symeonidis, Irini Konstantinidou, Myrto Christofidou, Ioannis Starakis, Alexandra Lekkou, Christos Papadimitriou, Alexandros Blikas, Nicholas Zoumbos, Chryssoula Labropoulou-Karatza

    2008-03-01

    Full Text Available AIM: To detect the prevalence of anti-HAV IgG antibodies in adult multitransfused beta-thalassemic patients.METHODS: We studied 182 adult beta-thalassemic patients and 209 controls matched for age and sex from the same geographic area, at the same time. Anti-HAV IgG antibodies, viral markers of hepatitis B virus (HBV and hepatitis C virus (HCV infection were evaluated.RESULTS: Anti-HAV IgG antibodies were detected more frequently in thalassemic patients (133/182; 73.1% than in healthy controls (38/209; 18.2%, P < 0.0005. When we retrospectively evaluated the prevalence of anti-HAV IgG antibodies in 176/182 (96.7% thalassemic patients, whose medical history was available for the previous ten years, it was found that 83 (47.2% of them were continuously anti-HAV IgG positive, 16 (9.1% acquired anti-HAV IgG antibody during the previous ten years, 49 (27.8% presented anti-HAV positivity intermittently and 28 (15.9% were anti-HAV negative continuously.CONCLUSION: Multitransfused adult beta-thalassemic patients present higher frequency of anti-HAV IgG antibodies than normal population of the same geographic area. This difference is difficult to explain, but it can be attributed to the higher vulnerability of thalassemics to HAV infection and to passive transfer of anti-HAV antibodies by blood transfusions.

  14. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats.

    Science.gov (United States)

    El-Beshbishy, Hesham A; Singab, Abdel Nasser B; Sinkkonen, Jari; Pihlaja, Kalevi

    2006-05-01

    The 70% alcohol extract of the Egyptian Morus alba L. root bark was fractionated over cellulose CC eluted with water, 50% methanol and finally with 100% methanol to yield 3 fractions (MRBF-1, MRBF-2 and MRBF-3), respectively. In continuation of chromatographic purification of 70% alcohol extract fractions of the Egyptian M. alba L. root bark, 4 compounds namely: mulberroside A, 5,7,2'-trihydroxyflavanone-4'-O-beta-D-glucoside and albanols A and B were isolated from MRBF-2 for the first time from the Egyptian plant. Experimentally induced atherosclerosis was produced by feeding rats a diet enriched in coconut oil (25% by weight) and cholesterol (2% by weight) for 21 days. Then, hypercholesterolemic rats were orally administered (MRBF-1, MRBF-2 and MRBF-3 fractions) in a dose of 500 mg kg(-1) day(-1) for 15 successive days, in order to evaluate their expected hypocholesterolemic activity. Lipid profile parameters such as plasma total cholesterol, LDL-C, VLDL-C, LDL:HDL ratio and triglycerides, as well as plasma and liver lipid peroxides and glutathione-S-transferase enzyme levels, serum paraoxonase enzyme level, LDL oxidation, LDL aggregation and LDL retention, were measured. Plasma and liver glutathione-S-transferase enzyme levels were unaffected in all studied groups. The results revealed that the administration of (MRBF-2 and/or MRBF-3) fractions resulted in alleviation of atherosclerotic state. Administration of MRBF-3 significantly retained plasma and liver peroxides towards their normal levels, and also, produced significant increase in resistance towards major atherogenic modifications; namely LDL oxidation, LDL aggregation and LDL retention by 44%, 30%, and 33%, respectively. Thus, it can be concluded that the consumption of MRBF-2 and (MRBF-3, in some extent) fractions of M. alba L. root bark 70% alcohol extract may act as a potent hypocholesterolemic nutrient and powerful antioxidant via the inhibition of LDL atherogenic modifications and lipid peroxides formation in hypercholesterolemic rats. PMID:16313926

  15. Passive and active measurements of Egyptian monazite samples.

    Science.gov (United States)

    Sroor, A

    2003-02-01

    Five samples of Egyptian monazite from beach black sand at Abou Khashba near Rosetta, North Egypt were separated in the laboratories of the nuclear materials authority of Egypt. Neutron activation analysis has been used to determine the elemental content of monazite samples. Twelve elements Sc, Cr, Fe, Co, Zn, Cs, La, Eu, Sm, Hf, Pa and Np are observed and the concentrations of these elements have been calculated. Using passive measurements natural radioactivity has also been determined in Bq/kg for the investigated monazite samples. Th and U concentrations from both passive and active measurements are in agreement. Some of the observed elements have a high economic value. PMID:12573329

  16. Quantitative analysis of ancient Egyptian pigments by external PIXE

    Energy Technology Data Exchange (ETDEWEB)

    Uda, M. (Dept. of Materials Science and Engineering, Waseda Univ., Tokyo (Japan) Lab. for Materials Science and Technology, Waseda Univ., Tokyo (Japan)); Tsunokami, T.; Murai, R. (Dept. of Materials Science and Engineering, Waseda Univ., Tokyo (Japan)); Maeda, K. (Inst. of Physical and Chemical Research (RIKEN), Wako, Saitama (Japan)); Harigai, I.; Nakayama, Y.; Yoshimura, S. (Egyptian Culture Center, Waseda Univ., Tokyo (Japan)); Kikuchi, T. (Dept. of Archaeology, Waseda Univ., Tokyo (Japan)); Sakurai, K. (Section of Archaeology, Showa Women' s Univ., Tokyo (Japan)); Sasa, Y. (Lab. for Materials Science and Technology, Waseda Univ., Tokyo (Japan))

    1993-04-01

    Pigments painted on Egyptian excavations in the 18th Dynasty were analyzed successfully by external PIXE with the aid of the X-ray diffraction. A white pigment was composed on Mg[sub 3]Ca(CO[sub 3])[sub 4]; red: [alpha]Fe[sub 2]O[sub 3], [alpha]FeO.OH and AsS; pink: Mixtures of white and red pigments; yellow: [alpha]FeO.OH and As[sub 2]S[sub 3]; and blue: CaO.CuO.4SiO[sub 2]. (orig.).

  17. Gamma dose measurements indoor and outdoor of some egyptian buildings

    International Nuclear Information System (INIS)

    Some physical parameters affecting the basic dosimetric properties of carbonized aluminum oxide were studied such as Response, Dose recovery, reproducibility, linearity and lower limit of detection. Indoor and Outdoor gamma radiation dose rates were measured inside and outside some Egyptian buildings using Al2 O3-C environmental thermo luminescence dosimeters for 70 days. For these purpose twenty dosimeters of TLD chips were positioned indoor and ten dosimeters were positioned outdoor inside a thin black polythene 30 cm long pipe at one meter above ground as a reference height

  18. Tolerance, Quality and Storability of Gamma-Irradiated Egyptian Rice

    International Nuclear Information System (INIS)

    The effect of gamma irradiation on some organoleptic and physico-chemical properties and the storability of Egyptian rice was investigated. Radiation up to 50 krad was chosen as an adequate dose causing non-significant changes in eating and cooking qualities. The effect of irradiation on degradation of starch and protein molecules is demonstrated on the basis of studies on the viscosity and solubility of rice paste. Irradiation at relatively low dose levels up to 50 krad did not affect the chemical and nutritional qualities of rice regarding amino acids and B vitamins. It was also found that irradiation maintains better storability of rice under ambient temperature. (author)

  19. Breaking Up the Family: Divorce in Egyptian Law and Practice

    OpenAIRE

    Bernard-Maugiron, Nathalie; Dupret, Baudouin

    2008-01-01

    From the twentieth century onward, Egyptian law-makers strived to re-instate a balance between men and women in their access to breaking-off the marriage. The legislature started interfering in new fields to favor the adaptation of law to the evolution of society and to find solutions to social problems it was confronted with. The study of the explanatory notes of the laws discloses this very spirit. The outcome of those reforms is, however, mitigated. No doubt women's status in divorce has i...

  20. Mitochondrial Mutation In Egyptian Patients With Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Fawzi O,A*; Hassan Z,A*; Abdel Kawy S,I**; Al-Diwany O,I**; Adel

    2006-06-01

    Full Text Available Mitochondrial gene mutation plays a role in the development of diabetes mellitus. An A to G substitution at base pair 3243 in the mitochondrial tRNAleu(UUR gene (mt3243 is commonly associated with maternally inherited diabetes and deafness and other diseases. The aim of this study is to detect A to G substitution at base pair 3243 in mitochondrial RNAleu(UUR in the plasma of patients with type 2 diabetes mellitus, and to evaluate insulin sensitivity in all cases. This study, included 41 patients (Group I, 31 cases with type 2 diabetes mellitus and maternal history of diabetes mellitus-and Group II, 10 cases with type 2 diabetes mellitus, bilateral SNHL, maternal history of diabetes mellitus with or without SNHL. Other10 healthy control group was included. Patients and controls were subjected to full medical history and clinical examination. Serum measurements for liver and kidney function tests, fasting and postprandial blood glucose as well as C-peptide levels, in addition to lipid profile were collected. Audiological evaluation for all patients with SNHL was also done. Genetic investigation, for mDNA analysis, done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP, to determine the mutation in the mitochondrial gene at position 3243. Results of the study showed that glycemic indices (FPG, 2hPPG and HbA1c, liver enzymes and blood urea were significantly higher among patient group compared to control group (P<0.05. There was no significant difference for values of creatinine and uric acid between cases and controls. Lipid profile was significantly higher among patient group compared to controls (P<0.05, except for HDL-C which was higher in controls however, it did not reach statistical significance. C-peptide values were not significantly different between studied groups. Age at onset of diabetes was relatively earlier in group II than group I. mDNA was present in all plasma samples of patients and controls. mDNA 3243 mutation was detected in the plasma of three patients with diabetes and SNHL with a rate of 7.3% of all diabetic patients and 30% of diabetic patients associated with deafness. The presence of mDNA mutation allowed 294 bp product to be cleaved into 180 and 114 bp fragments and were seen as two bands. In CoclusioN: The A 3243 G mutation is present in Egyptian population and is considered as a cause of maternally inherited diabetes and deafness at a rate of 7.3% of all diabetic subjects and a rate of 30% of diabetics associated with deafness. mDNA mutation is present and detectable in plasma. Maternally inherited diabetes and deafness differs pathophysiologically from the more common forms of type 2 diabetes in that, insulin resistance does not seem to be a major factor.

  1. Legal Elements For Nuclear Security: Egyptian Nuclear Law As A Case Study

    International Nuclear Information System (INIS)

    This paper deals with the legal bases for nuclear security. First, It analysis the international legal framework for nuclear security. Second, it analysis the legal bases for the import-export control. The legal aspects related with illicit trafficking (IT) were also reviewed. Third, It deals with the Egyptian nuclear law no. 7 and its executive regulation. The Egyptian legal regime for nuclear security and the role of State System for Accounting and Control of Nuclear Materials (SSAC) in realizing the nuclear security were also discussed. The purpose of the paper is to evaluate the Egyptian legal framework for nuclear security.

  2. Designing an e-democracy framework to enhance the Egyptian e-government

    Directory of Open Access Journals (Sweden)

    M. El-Sayed Wahed

    2013-08-01

    Full Text Available E-democracy concept can enhance Egyptian participation in rule and it can move e-the Egyptian government to a new era. E-democracy concept can be applied in conjunction with database connection to transfer Egyptian e-government to transformation stage. This Paper concentrates mainly on designing an e-democracy framework using two case studies in e-government systems .As we will see system is web based application based .There are some figures that describe system architecture then each component well be explained. The framework technical aspects, analysis and objectives in establishing integrated e-government will be discussed. 

  3. X-ray analysis of pigments on ancient Egyptian monuments

    Energy Technology Data Exchange (ETDEWEB)

    Uda, M.; Sassa, S.; Yoshioka, T. [Waseda Univ., Department of Materials Science and Engineering, Tokyo (JP)] [and others

    1999-07-01

    Ancient pigments were analyzed using PIXE and XRD methods in the laboratory, which were painted on ancient Egyptian monuments. On the other hand, those on monuments remaining with entire shape were investigated using the hand-held type of an XRF spectrometer and an X-ray diffractometer in the field. For the laboratory experiment, several wall fragments of the Malqata palace in ancient Egypt (18th Dynasty, ca. 1390 B.C.) were investigated. In the field experiment, the block of Ramesses II (19th Dynasty, ca. 1270 B.C.), the Wooden Coffin of Neb-sny (18th Dynasty, ca. 1400 B.C.), the Funerary Stele of Amenemhat (11th Dynasty, ca. 2000 B.C.), and the painted walls of the Tomb of Userhat (18th Dynasty, ca. 1400 B.C.) were investigated. From white and blue colored parts, huntite and Egyptian blue were found, respectively, which are a very rare mineral and an artificial pigment prepared only in ancient Egypt, respectively. (author)

  4. Engineering properties of cement/lime-stabilized Egyptian soft clay

    Science.gov (United States)

    Mansour, M. A.; Samieh, A. M.; Matter, H. E.

    2015-09-01

    Soft clay formations are extensively located in many coastal areas around the world. The significant high compressibility and low shear strength of these formations impose challenging engineering problems. The deep cement/lime-mix-in-place method is one of the ground improvement techniques exhibiting successful use in stabilizing soft clay. Analysis and design of the deep mixing systems necessitate the identification of the additive content, the proportions of the lime to cement and the characteristics of the stabilized clay. This paper investigates experimentally the influence of adding lime and cement or cement alone, as stabilizing additives, on the engineering behavior of an Egyptian soft clay extracted from the north delta region. A series of laboratory tests were carried out considering, different additive contents of 8, 10, 12, and 14% of the dry weight, with different proportions of lime to cement of 50:50, 25:75 and 0:100. A series of unconfined compression strength tests were performed after different periods; one week, four weeks and 8 weeks, to assess the effect of curing period on the stabilized clay response. In addition, one dimensional consolidation tests were carried out to evaluate the compressibility properties of the stabilized clay. This study declared that the use of an additive content in the range of 12% and more is recommended to improve the characteristics of the considered Egyptian clay. It was pointed out that addition of lime and cement to soft clay significantly increases the strength characteristics and significantly reduces the compressibility characteristics of such clay.

  5. Determination of Wax Content in Egyptian Crude Oils

    Directory of Open Access Journals (Sweden)

    Prof.Dr.Ramadan Abu El-Ella

    2014-02-01

    Full Text Available Wax precipitation is one of the most important flow assurance problems. Unfortunately, experimental data are very scarce to confirm existing models for prediction of such production impairment and other hazardous risk; while its curative approaches and production losses add to colossal economic sabotage to the petroleum industry. The present work deals with studying the determination of wax in Egyptian crude oil by gravimetric determination precipitation with lowering temperature of the crude oil .The crude oil studied was from Egyptian western desert (waxy paraffinic crude. Waxes may precipitate due to a temperature decrease because their solubility is so low that a solid phase can appear. The experiments investigated the effect of initial weight of the crude, the time of cooling, and the temperature on the amount of wax produced. The highest amount of wax was produced with 150gm of the crude oil, at temperature of 0oC and this was done within two hours of the time of experiment. Finally the effect of using solvent on the amount wax content was also studied and it was found that the ratio (3:1 of solvent mixture increases achievement of the maximum amount of wax produced.

  6. X-ray analysis of pigments on ancient Egyptian monuments

    International Nuclear Information System (INIS)

    Ancient pigments were analyzed using PIXE and XRD methods in the laboratory, which were painted on ancient Egyptian monuments. On the other hand, those on monuments remaining with entire shape were investigated using the hand-held type of an XRF spectrometer and an X-ray diffractometer in the field. For the laboratory experiment, several wall fragments of the Malqata palace in ancient Egypt (18th Dynasty, ca. 1390 B.C.) were investigated. In the field experiment, the block of Ramesses II (19th Dynasty, ca. 1270 B.C.), the Wooden Coffin of Neb-sny (18th Dynasty, ca. 1400 B.C.), the Funerary Stele of Amenemhat (11th Dynasty, ca. 2000 B.C.), and the painted walls of the Tomb of Userhat (18th Dynasty, ca. 1400 B.C.) were investigated. From white and blue colored parts, huntite and Egyptian blue were found, respectively, which are a very rare mineral and an artificial pigment prepared only in ancient Egypt, respectively. (author)

  7. Chemical Evaluation of Irradiated Egyptian Truffles

    International Nuclear Information System (INIS)

    The main objective of this study is to investigate and evaluate the chemical compositions of irradiated and non-irradiated truffles (Al-Kamah)as a natural product for human nutrition with concentrated high value protein supplementation. White and brown truffles grow in Egypt and White truffle is identified as Tirmania nivea and brown truffle is identified as Terfezia budiari. Field survey for four truffle seasons including the best habit for production in Sidi Barani and Salum. Chemical composition of fresh and stored truffles indicated some differences between the two studied species. It was found that the white truffle had higher contents of carbohydrate and fat (45.5% and 7.2%), thenbrown truffle (47.5% and 7.5%)respectively, while the browntruffle had the higher contents of proteins, fiber and ash (23.8%, 8%, and 14%) than the white (22.8, 7.5 and 8% resp.). Cysteine was the highest amino acid in white truffle, while isoleucine was the highest one in brown truffle. The major fatty acids appeared in white and brown truffles were linoleic (46 and 28.3%) and Oleic (37.5 and 6209%) of total fatty acids. B-sitosterol was the major sterol in white truffle while stigmasterol in brown truffle (3.4% and 42.6%). The phytochemical screening revealed that numerous compounds are present as saponins, alkaloids, nitrogen bases,sterols, triterpenes and glycosides. The effect of irradiation (2 K Gy) was limited on bio-component. On the other hand, the biochemical components were investigated in irradiated truffle as a method for preservation. Some changes were observed during storage for 2 months. These chages affect the nutrition value of truffle

  8. Chemical composition of water hyacinth (Eichhronia Crassipes) a comparison indication of heavy metal pollution in egyptian water bodies. Vol. 4

    International Nuclear Information System (INIS)

    Water hyacinth is tested as an indicator for pollution in egyptian fresh surface waters. Chemical composition of water hyacinth as affected area of collection (water bodies) was studied and the suitability of this plant as a biological indicator for water pollution is discussed. Water hyacinth samples were collected three times per year for two years (1991-1993). Sample sites include one location in the river nile (at Helwan area), one site in Ismaillia canal, (at Mostrod industrial area), and one site in Abo-Zabal drain (at Abo-Zabal city). The concentration of 19 major major and trace elements in plant samples were determined by prompt gamma-ray neutron activation analysis. Results indicated that plant parts as well as location have a significant effect on elements content. Water hyacinth roots showed high affinity for accumulation of trace elements. 5 tabs

  9. Planning closure safety assessment for the Egyptian near surface disposal facility

    International Nuclear Information System (INIS)

    The development of a repository is a significant national effort requiring several decades to complete, as well as a substantial amount of skilled human, economical and technical resources. Planning and implementation of different disposal activities proceed in a stepwise manner, guided by decision points. Granting license is considered one of the major decision points that require the presentation of a safety case to evaluate the acceptability of the repository practice. The Egyptian regulation requiring the conduction of safety assessment studies as an essential requirement in license application for construction, operation, and closure of a near surface disposal. Closure of a disposal facility is the last major operational step in completing the disposal system. It requires the consideration of a combination of scientific, engineering, regulatory, and socio-economic factors that are integrated and optimized to select cost-effective alternatives acceptable to all interested parties. In this work, a general framework will be established to conduct a safety assessment methodology for closure of near surface disposal. (author)

  10. An investigation into the ancient Egyptian cultural influences on the Yorubas of Nigeria

    Directory of Open Access Journals (Sweden)

    Jock M. Agai

    2013-01-01

    Full Text Available There are many cultural practices that connect ancient Egyptians to the Yorubas and the new interpretation of the Oduduwa legend suggests that the Yorubas have originated or are influenced mainly by the Egyptians. The attestation of Egypt as the main influencer of the Yoruba culture made Egypt significant in the study of the history of the Yoruba people. Some writers are beginning to think that the ancient Egyptians were responsible for introducing and spreading many cultures amongst the Yorubas. As more Yorubas are tracing their origins and the origins of their culture to ancient Egypt, this research investigates whether the Egyptians were the originators and the main spreaders of the afterlife culture in Yorubaland.

  11. An investigation into the ancient Egyptian cultural influences on the Yorubas of Nigeria

    Scientific Electronic Library Online (English)

    Jock M., Agai.

    Full Text Available There are many cultural practices that connect ancient Egyptians to the Yorubas and the new interpretation of the Oduduwa legend suggests that the Yorubas have originated or are influenced mainly by the Egyptians. The attestation of Egypt as the main influencer of the Yoruba culture made Egypt signi [...] ficant in the study of the history of the Yoruba people. Some writers are beginning to think that the ancient Egyptians were responsible for introducing and spreading many cultures amongst the Yorubas. As more Yorubas are tracing their origins and the origins of their culture to ancient Egypt, this research investigates whether the Egyptians were the originators and the main spreaders of the afterlife culture in Yorubaland.

  12. An investigation into the ancient Egyptian cultural influences on the Yorubas of Nigeria

    Directory of Open Access Journals (Sweden)

    Jock M. Agai

    2013-07-01

    Full Text Available There are many cultural practices that connect ancient Egyptians to the Yorubas and the new interpretation of the Oduduwa legend suggests that the Yorubas have originated or are influenced mainly by the Egyptians. The attestation of Egypt as the main influencer of the Yoruba culture made Egypt significant in the study of the history of the Yoruba people. Some writers are beginning to think that the ancient Egyptians were responsible for introducing and spreading many cultures amongst the Yorubas. As more Yorubas are tracing their origins and the origins of their culture to ancient Egypt, this research investigates whether the Egyptians were the originators and the main spreaders of the afterlife culture in Yorubaland.

  13. Serum Asymmetric Dimethylarginine, and Adiponectin as Predictors of Atherosclerotic Risk among Obese Egyptian Children

    Directory of Open Access Journals (Sweden)

    Enas R. Abdel Hameed

    2014-06-01

    CONCLUSIONS: Our results revealed that ADMA, Adiponectin and lipid profile can be considered as predictive biomarkers in prediction and prevention of atherosclerotic risk in the future among overweight and obese Egyptian children.

  14. Major depression

    Science.gov (United States)

    Depression - major; Depression - clinical; Clinical depression; Unipolar depression; Major depressive disorder ... Doctors do not know the exact causes of depression. It is believed that chemical changes in the ...

  15. A bleaching earth from egyptian local deposits

    Directory of Open Access Journals (Sweden)

    El Kinawy, Omayma S.

    2001-10-01

    Full Text Available The present investigation deals with the bleaching of vegetable oils using activated clays collected from some deposits in Egypt as compared to Tonsil FF currently used by local oil industry. The comparison was made; not only on the basis of the decolourising power of the earth, but also on the basis of its effects on the oil acidity, formation of the oil peroxides and the decomposition rate of the formed peroxides to aldehydes and ketones during the bleaching process. The activation of the collected earth samples was made using 4N HCl, 6N HCl and 30 % H2SO4. The bleaching tests of the activated samples were performed using the major four oil types processed in Egypt being cottonseed, sunflower, soybean and palm oils. In addition to the laboratory-evaluation tests, the performance of the activated samples, which showed promise on the lab-scale have been also tested on an industrial scale. The industrial application has proved that the activated local earth's can be successfully used as bleaching earth of local oils. Thus it can be used as a substitute of the varieties currently imported and used by the local oil sector.La presente investigación trata de la decoloración de aceites vegetales usando tierras activadas obtenidas de yacimientos egipcios, comparándola con el Tonsil FF usado normalmente en la industria oleícola local. La comparación se realizó, no sólo sobre la base del poder decolorante de la tierra, sino también sobre la base de sus efectos en la acidez del aceite, la formación de peróxidos y la velocidad de descomposición de los peróxidos formados en aldehidos y cetonas durante el proceso de decoloración. La activación de las muestras de tierras recogidas se hizo utilizando ClH 4N, ClH 6N y H2SO4 30 %. Los tests de decoloración de las muestras activadas se llevaron a cabo usando los cuatro tipos mayoritarios de aceites procesados en Egipto: aceite de semilla de algodón, de girasol, de soja y de palma. Además de los tests a escala de laboratorio, la evaluación de las muestras activadas, se realizó a escala industrial. La aplicación industrial ha demostrado que las tierras locales activadas pueden ser utilizadas con éxito como tierras decolorantes de aceites locales. De este modo pueden usarse como sustitutos de las variedades mas frecuentemente importadas y usadas por el sector aceitero.

  16. The future of the independent Egyptian music in the digital era

    OpenAIRE

    Maraghah, Mohammad

    2013-01-01

    This thesis is investigating the impact of the digital era with its technological advanced components and revolutionized information platforms on shaping the future of the independent Egyptian music. The author investigated this impact through conducting fifteen semi structured qualitative interviews between the 15th of December 2012 to 25th of January 2013 with the relevant Independent Egyptian Music stakeholders who gave the researcher a better insight of what is the optimal business model(...

  17. Determinants of Exclusive Breastfeeding and Introduction of Complementary foods in Rural Egyptian Communities

    OpenAIRE

    Arwa Mohamed Hosney El Shafei; John Rene Labib

    2014-01-01

    Background: Determinants of breastfeeding (BF) exclusivity at a rural Egyptian setting are largely unknown. This cross-sectional study aimed to assess BF indicators, specifically exclusivity and the timely complementary feeding while assessing potential determinants that affect exclusivity of BF among a sample of mothers inhabiting Egyptian rural communities. Methods: A community based cross-sectional study was carried out over a period of four months with inclusion of 1000 eligible women hav...

  18. BENCHMARKING THE EGYPTIAN MEDICAL TOURISM SECTOR AGAINST INTERNATIONAL BEST PRACTICES: AN EXPLORATORY STUDY

    OpenAIRE

    Eman M. Helmy

    2011-01-01

    This paper argues that any compatible strategy for the development of medical tourism at a developing nation should be based primarily on a comprehensive benchmarking study. It has employed the benchmarking phase of a national project for the development of an Egyptian medical tourism strategy to showcase significance of such benchmarking implications. The benchmarking phase of the Egyptian project has used two main data sets to reach reliable findings: a series of best practice destinations ...

  19. Egyptian greenhouse cultivation at a higher level with Dutch Technology ; Annual Report 2013

    OpenAIRE

    Elings, A.; Helm, F.P.M., van der; Blok, C.; Meijer, R.J.M.; Lahiani, Y.; Janmaat, A; Zaki, M.; H. Hassan

    2014-01-01

    The project ‘Egyptian greenhouse cultivation at a higher level with Dutch technology’ is co-funded under the Top Sector Programme Horticulture and Starting Materials. The project wants to realizes through the use of Dutch technology a higher level of sustainability of Egyptian protected cultivation, especially in the areas of water and crop protection. Collaborating private partners are Koppert and HortiMaX in The Netherlands, and BioEgypt and AllGreen in Egypt. Wageningen UR Greenhouse Horti...

  20. Application of Neutron Activation Analysis Technique for Gold Estimation in South Area Egyptian Mines

    International Nuclear Information System (INIS)

    The study presents analytical results of gold concentrations of some Egyptian gold ores. Six samples collected from south eastern of Egyptian mines area have been analyzed using neutron activation analysis technique. The gamma-ray spectra obtained were measured by means of high resolution hyper-pure germanium detection system in conjunction with electronic and computerized multichannel analyzer. The results are compared with previous measurements obtained by another method

  1. Induction of neoplasms in the Egyptian toad Bufo regularis by gibberellin A3.

    Science.gov (United States)

    el-Mofty, M M; Sakr, S A

    1988-01-01

    Force feeding the Egyptian toads (Bufo regularis) with gibberellin A3 (10 ppm) twice a week for 5 months induced neoplasms in 8 out of 50 (16%) experimental animals. Primary tumours developed in the liver (hepatocellular carcinomas). Two secondary tumours in the kidneys and another 2 in the ovaries of toads developed due to metastases from the hepatocellular carcinomas. The results show that gibberellic acid (gibberellin A3) has a carcinogenic effect in the Egyptian toads. PMID:3340394

  2. The impact of organizational characteristics on AMT adoption: A study of Egyptian manufacturers

    OpenAIRE

    Salaheldin, S.I.

    2007-01-01

    Purpose - This research seeks to empirically explore and examine the impact of organizational characteristics, i.e. firm size, type of production system, organizational design and type of ownership, on advanced manufacturing technology (AMTs) adoption in the Egyptian industrial sector; and to identify the similarities and dissimilarities of the nature of AMT adoption in Egypt compared to different contexts. Design/methodology/approach - The analysis was based on a survey of 200 Egyptian manuf...

  3. Nitrogenase Activity of Pseudomonas corrugata Isolated from Egyptian Lettuce

    OpenAIRE

    Emad A. Abada

    2006-01-01

    In the present study an isolate capable of root colonization of Egyptian Lettuce was isolated from the roots after selective enrichment. The isolated strain was identified as Pseudomonas corrugata by using Biochemical and Biolog identification system. The isolate has been found to be positive for nitrogenase activity. This root-colonized bacterium has not been previously isolated from Egyptian Lettuce and could be used as a bio-fertilizer.

  4. The Radial Structure of Some Middle Egyptian Prepositions

    DEFF Research Database (Denmark)

    Nyord, Rune

    2010-01-01

    Prepositions are traditionally treated in dictionaries and grammars by giving a list of usages, often corresponding more or less to the way the preposition is translated in the language of the modern work. This paper suggests an alternative way of approaching prepositions, derived from cognitive linguistics where prepositions are regarded as categories centered on a salient prototype from which various peripheral members of the category are derived. This perspective has the advantage of presenting the meaning of each preposition as a unified category with a specific central meaning and various extensions, instead of merely listing a number of unrelated senses. It is argued that Middle Egyptian prepositions can fruitfully be studied in this framework, and the method is exemplified by examining the conceptual structure of the two frequent prepositions m and r.

  5. Studies on natural radioactivity of some egyptian building materials

    International Nuclear Information System (INIS)

    Using high-resolution y-rays spectrometry, the natural radioactivity of 14 samples of natural and o manufactured Egyptian building materials have been investigated. The samples were collected from local market and construction sites. From the measured gamma-ray spectra, specific activities were determined. The radium equivalent activity in each sample was estimated. Radiological evaluations of these materials indicate that all materials meet the external gamma-ray dose limitation. Calculation of concentration indices by assuming a Markkanen room model is constructed from these materials, to find the excess gamma-ray dose taken over that received from the outdoors. The Austrian Standard ONORM S 5200 is used in testing the building materials

  6. Characterization of Gamma-Irradiated Egyptian Wheat Flour

    International Nuclear Information System (INIS)

    Physical, rheological and baking properties of bread Shamy, prepared from gamma-irradiated Egyptian wheat flour up to 25 KGy as one of common types of bread in Egypt, were studied and the acceptability of bread was evaluated by sensory tests. All amylo-, farino-, and extensograph characteristics and also sample ph showed significant decrease as irradiation dose increased. Such results could be explained in terms of loss of unique elastic and cohesive properties of wheat gluten and starch damage upon increment of radiation dose. The improvement in properties of bread, baked from flour irradiated up to 7.5 KGy, could be explained on the basis of a simulation in gas production during dough fermentation due to increase in starch degradation products. However, bread, prepared from wheat samples irradiated above 7.5 KGy, exhibited significantly lower values of acceptance because of physico-chemical changes in both starch and gluten

  7. The Reasons social media contributed to 2011 Egyptian Revolution

    Directory of Open Access Journals (Sweden)

    Rabia Minatullah Sohail, Nadine Chebib

    2011-10-01

    Full Text Available In recent years, social media has become very significant for social networking. In the past, itsmain use was personal, but nowadays, its becoming part of all facets of our lives, social andpolitical. In the first quarter of 2011, the Middle East has witnessed many popular uprisings thathave yet to reach an end. While these uprisings have often been termed “FacebookRevolutions” or “Twitter Revolutions”, there are many ambiguities as to the extent to whichsocial media affected these movements. In this paper we discuss the role of social media andits impact on the 2011 Egyptian revolution. Though the reasons for the uprising were manifold,we will focus on how social media facilitated and accelerated the movement.

  8. Gall bladder sludge and stones in multitransfused Egyptian thalassaemic patients.

    Science.gov (United States)

    el-Nawawy, A; Kassem, A S; Eissa, M; Abdel-Fattah, M; Safwat, M

    2001-01-01

    One hundred Egyptian beta-thalassaemic patients on a long-term transfusion/chelation programme were evaluated for the prevalence of gall bladder sludge and stones and the associated risk factors. Fifty healthy individuals served as controls. Abdominal ultrasonography revealed that 14% of the thalassaemic patients had gall bladder sludge or stones (6% stones and 8% sludge). The thalassaemic patients with this complication were older, had a higher prevalence of gall bladder symptoms, higher levels of pretransfusion haemoglobin, larger amounts of transfused red cells, and more were regularly transfused. Multiple logistic regression analysis revealed that the presence that gall bladder symptoms and the amount of transfused red cells were the only significant predictors of the occurrence of gall bladder sludge or stones. PMID:15332759

  9. Dose Assessment of Natural Radioactivity in Ancient Egyptian Monuments

    International Nuclear Information System (INIS)

    Within an environmental radiation investigation of the ancient Egyptian monuments sites, 151 environmental samples were analyzed using ?-ray spectrometers based on HPGe detectors. The results show that the activity concentration values of the naturally occurring radionuclides; 238U (22'6Ra), 232Th, and 40K respectively, are within the world average ranges.Two models for calculation of absorbed dose rate due to gamma emission from radionuclides in the studied soil, limestone and adobe samples were evaluated. The first model was established based on constant value of sample density. The second model takes the density variation into consideration. Two sets of conversion factors were evaluated. A comparison between the results of calculation of the absorbed dose of the studied samples based on the model adopted by UNSCEAR and on our two models was carried out and discussed. (authors)

  10. HOW EGYPTIAN CONTRACTING COMPANIES TRANSLATE PROJECTS' QUALITY TO PROJECTS' PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Said SHAWKY HOZIEN

    2011-07-01

    Full Text Available A model for continuous quality improvement for Egyptian contracting projects’ (CQIM is developed through the extensive reviewing of the Total Quality Management (TQM, Continuous Quality Improvement (CQIliterature, preceding researches, consensus opinions of managers and experts of the construction industry and the quality management system (ISO 9000. This model comprises of 13 main factors divided into 9 CQI constructs and 4 Indices, the Indices are broken down to 46 practical measures, while the CQI constructs are further divided into 58 sub-factors consisting of 231 practical requirements, all targeting the evaluation and improvement of the overall project performance (OPP . This model assists its users to assess their points of weaknesses and strengths, by setting-up a road map for improvement, utilizing a guided framework. This model is used as a benchmarking tool to achieve the goal of this research “Projects' Continuous Quality Improvement”.

  11. Parasitic copepods from Egyptian Red Sea fishes: Bomolochidae Claus, 1875.

    Science.gov (United States)

    El-Rashidy, Hoda Hassan; Boxshall, Geoffrey Allan

    2016-02-01

    Two species of parasitic copepods from the genus Bomolochus von Nordmann, 1832 (Cyclopoida: Bomolochidae) are redescribed in detail, based on material collected from the gills of Red Sea fishes. Host material was caught at El-tor, near Sharm El-Sheikh, and in the Gulf of Suez, Egypt. Both sexes of Bomolochus bellones Burmeister, 1835 were collected from the gills of a needlefish Tylosurus choram (Rüppell) caught in the Gulf of Suez. This is a new host record. The female is well characterised so only the male is described. Adult females of Bomolochus minus Lin & Ho, 2005 were obtained from the branchial cavities and gills of mojarra Gerres oyena (Forsskål). This species was known only from its original description in Taiwan, and this report constitutes a new host record and a significant range extension. Both parasite species are new records for Egyptian Red Sea waters. PMID:26790683

  12. Environmental Monitoring of Toshki Region As a New Egyptian Community

    International Nuclear Information System (INIS)

    Some heavy metal pollutants namely Cd, Co, Cu, Fe, Mn, Ni, PI and Zn were measured in water, soil and some fruit plants; Citrus finensis, Orantte folia, Citrus aurantium and Vitis vinifera in Toshki region. These samples were collected in March 2005. The samples were treated according to the Standard Operation Procedures, digested and analyzed using an atomic absorption spectrophotometer. It was found that the mean concentrations of the mentioned elements in water samples are higher than those corresponding by environmental Law. While, the concentrations of those elements in soil samples are two folds higher than those found in plant samples. The results are related to those give by the Egyptian environmental Law No. 4/1994. In addition, natural radioactivity levels for 226Ra, 232Th, 40K and137Cs in soil were found to be lower than those corresponding for United Nations Scientific committee on the Effect of Atomic Radiation (UNSCEAR) values. The results are discussed and recommendations are suggested

  13. Electrophoretic Characterization and the Relationship Between Some Egyptian Cruciferae

    Directory of Open Access Journals (Sweden)

    E.A. Kamel

    2003-01-01

    Full Text Available The present study was carried out on 17 Egyptian taxa of the Cruciferae representing 10 genera and 13 species collected from different localities. Polyacrylamide gel electrophoresis (SDS-PAGE was employed to characterize those taxa. The data obtained were analyzed by the NTsys-pc program package using the UPGMA clustering method. The produced dendrogram from SDS-PAGE analysis showed a close affinity and the monophyllay among the species of the genera; Enarthrocarpus Labill., Farsetia Turra, Zilla Forssk. and the paraphyllaly within the species of the genus Brassica L.

  14. Underuse of controller medications in Egyptian asthmatic children

    Directory of Open Access Journals (Sweden)

    Osama Amer

    2013-01-01

    Full Text Available Background: International guidelines recommend daily use of controller medications for children with persistent asthma. Several studies from different regions of the world have reported low asthma control among children. Objectives: To assess the frequency of underuse of controller medications in Egyptian children and to clarify the causes and predictors for this underuse. Methods: This observational cross-sectional study was held over a 12-month-period in Zagazig University Hospitals, including 460 children with persistent asthma. All studied patients were submitted to careful history taking, proper medical examination and subsequent sharing, with their parents, in filling a previously designated Arabic asthma interview format concerning the disease course, medications, parents' beliefs about asthma, and causes of underuse. Results: Of 460 children who have persistent asthma, 84.4% were underusers of controller therapy, with 63.5% reporting no controller use at all and 21.3% reporting improper use. More than half of the studied patients received their medications in emergency department (52.8%, and follow up with a general practitioner (52.2% with less attendance to our outpatient asthma clinic (15.2%. The most important causes of underuse are non-prescription of controller drugs by managing physician (45% and financial cost (28%. Furthermore, predictors of this underuse include false beliefs about asthma (OR = 56.2; 95% CI: 13.5-232, P<0.05, negative family history of atopy (OR = 2.4; 95% CI: 1.10-5.18, P<0.05, younger age of the patients (P< 0.05, and general practitioner as the treating physician (OR = 3.5; 95% CI: 1.99-6.16, P<0.05. Conclusion: There is high frequency of underuse of controller medications among Egyptian asthmatic children. Non-prescription of controller medications by managing physician and financial cost remain the most important direct causes of underuse.

  15. Sesame seed sensitization in a group of atopic Egyptian children.

    Directory of Open Access Journals (Sweden)

    Samar Ahmad

    2013-10-01

    Full Text Available Background: There are no published data on the prevalence of sesame allergy/sensitization in Egypt. Objective: In this pilot study, we thought to estimate the frequency of sesame seed sensitization in a group of atopic Egyptian infants and children. Methods: We consecutively enrolled 90 patients with physician diagnosed allergic disease. The study measurements included clinical evaluation for the site and duration of allergy, history suggestive of sesame seed allergy, and family history of allergy, as well as skin prick testing (SPT using a commercial sesame extract, and serum sesame specific IgE (SpIgE estimation. Results: None of the studied patients reported symptoms suggestive of sesame seed allergy. Nevertheless, two children (2.2% showed positive SPT response to sesame (wheal diameter ≥ 3 mm above the negative control. Only one of them had a wheal diameter which exceeded that of the histamine control. The serum sesame SpIgE exceeded 0.35 IU/ml in all subjects [range = 0.35 - 3.0 IU/ml; median (IQR = 0.9 (0.6 IU/ml]. Serum sesame SpIgE was significantly increased in patients with history of recurrent urticaria (p=0.03. Conclusion: Sesame seed sensitization is not uncommon in atopic Egyptian children. It can be associated with any clinical form of allergy and the causal relationship needs meticulous evaluation. Wider scale population-based studies are needed to assess the prevalence of sesame allergy and its clinical correlates in our country

  16. A descriptive study of plasma cell dyscrasias in Egyptian population

    International Nuclear Information System (INIS)

    Background: Plasma cell dyscrasias (PCDs) refer to a spectrum of disorders characterized by the monoclonal proliferation of lymphoplasmacytic cells in the bone marrow and, sometimes, tissue deposition of monoclonal immunoglobulins or their components. These disorders include multiple myeloma (MM) and Waldenstrom’s macroglobulinemia, as well as rare conditions such as light-chain deposition disease (LCDD) and heavy-chain diseases (HCDs). The worldwide annual incidence of MM is estimated at 86,000, which is approximately 0.8% of all new cancer cases. Purpose: Our retrospective study aims to highlight the immunologic and epidemiological features of PCDs mainly MM in Egyptian patients and compare our results with those of other populations. Methods: Two hundred seventeen Egyptian patients with PCD were enrolled in the study. Serum, urine protein electrophoresis and immunofixation were used to demonstrate M protein. Results: One hundred thirty-eight patients (63.6%) had IgG monoclonal band, 38 patients (17.5%) had IgA, 12 patients (5.5%) had Waldenstrom’s macroglobulinemia (IgM monoclonal band) and 29 patients (13.4%) were light chain myeloma. One hundred fifty-one (70%) were Kappa chain positive and 66 patients (30%) were lumbda positive. Conventional cytogenetics was available for 40 patients; of them12 patients (30%) showed 13q-. Mean OS was 37.5 months (1-84 months). Survival analysis was statistically insignificant according to age, sex and ISS or type of treatment (P value >0.05). Conclusion: Long term follow up is required to further define the role of different therapeutic lines of treatment including ASCT in the various stages of PCD based on OS data.

  17. Physical Deterioration of Egyptian Limestone Affected by Saline Water

    Directory of Open Access Journals (Sweden)

    Mohammed EL-GOHARY

    2013-12-01

    Full Text Available This study is the second in a series of experiments that describe the chemical, physical and thermal properties of archaeological limestone affected by salt and saline water in Egypt. This research aims to study the aggressive physical effects of different types of salts dominated in saline water and their different mechanisms on the acceleration of weathering processes that affect Egyptian limestone. It presents a multidisciplinary approach to characterize, at both micro/macro scales, the behavior of a limestone widely used as a construction material in most of Egyptian monuments when interacting with some types of salt solutions of various concentrations. A systematic optical, morphological, physical and mechanical analysis of the fresh and weathered stone samples were used to evaluate different characteristics through using scientific some techniques such as optical microscope (OP and scanning electron microscope (SEM. In addition to the using of some special computer programs that were used to define different physical and mechanical properties such as weight changes, bulk density, total porosity, water uptake, water content, thermal dilatation and abrasion resistant. The results proved that all investigated samples were gradually affected by the types of salinity paths and salt concentrations. These results will serve as a database for the future comparison of long term behavior of stones before and after the planned conservation of the entire area. So, it is pertinent to device some scientific methods and interventions to reduce all factors of salt effects and removing their harmful aspects from historic fabric of the archaeological buildings through some scientific recommendations

  18. Plant Extract Control of the Fungi Associated with Different Egyptian Wheat Cultivars Grains

    Directory of Open Access Journals (Sweden)

    Mohamed Baka Zakaria Awad

    2014-07-01

    Full Text Available Grain samples of 14 Egyptian wheat cultivars were tested for seed-borne fungi. The deep freezing method was used. Five seed-borne fungi viz., Aspergillus flavus, A. niger, Curvularia lunata, Fusarium moniliforme and Penicillium chrysogenum were isolated from the wheat cultivars viz., Bani Suef 4, Bani Suef 5, Gemmiza 7, Gemmiza 9, Gemmiza 10, Giza 168, Misr 1, Misr 2, Sakha 93, Sakha 94, Shandaweel 1, Sids 1, Sids 2 and Sids 3. A. flavus, A. niger and F. moniliforme were the most prevalent fungal species. Their incidence ranged from 21.0-53.5%, 16.0-37.5%, and 12.0-31.0%, respectively. The antifungal potential of water extracts from aerial parts of five wild medicinal plants (Asclepias sinaica, Farsetia aegyptia, Hypericum sinaicum, Phagnalon sinaicum, and Salvia aegyptiaca were collected from the Sinai Peninsula, Egypt. The antifungal potential of water extracts from the aerial parts of these five plants were tested in the laboratory against the dominant fungi isolated from the wheat cultivars. All the aqueous plant extracts significantly (p ? 0.05 reduced the incidence of the tested seed-borne fungi. But the extract of Asclepias sinaica exhibited the most antifungal activity on tested fungi at all concentrations used when compared with other plant extracts. Maximum infested grain germination was observed in Giza 168 and minimum in Bani Suef 5. Treating grains with plant extract of A. sinaica (10% enhanced the percentage of grain germination of all cultivars in both laboratory and pot experiments. Maximum root and shoot length of seedlings was recorded in Bani Suef 4 during fungal infestation or treatment by plant extract. For one hour before sowing or storage, the aqueous extract of A. sinaica can be used to treat wheat grains, to reduce the fungal incidence. Aqueous extracts of the aerial parts of selected medicinal plants, particularly A. sinaica, are promising for protecting Egyptian wheat grain cultivars against major seed-borne fungi. The aqueous extracts are expected to improve crops.

  19. Determination of trace elements up to 300 PPM in some Egyptian mining samples by neutron activation analysis

    International Nuclear Information System (INIS)

    Six mining samples from south area of Egypt at Hemour, Um El-Garayat and El-Nile valley, were collected, prepared and irradiated at a thermal neutron flux of 4.3x1012 n / cm2.s. in the first Egyptian Research Reactor ( ET-RR-1 ) for 48 hours. A.HPGe detection system was used for the gamma-ray measurements emitted due to neutron activation. In addition to the major elements Na, Ca, Cr, Fe, Zn, As, Zr, Mo, Ba and Au appeared in the gamma-ray spectra obtained in these measurements, the following elements Sc, Co, Rb, Sb, La, Ce, Nd, Sm, Eu, Tb, Tm, Yb, Lu and Hf at trace level up to 300 ppm were identified. The concentration values of the trace elements were determined and compared with each other for the six investigated samples

  20. Effect of irradiation and storage on biogenic amine contents in ripened Egyptian smoked cooked sausage

    International Nuclear Information System (INIS)

    The effects of ?-irradiation upon the biogenic amine inventory in Egyptian smoked cooked sausages were investigated for the first time during storage for up to 90 days at 4 ° C. Typical contents of biogenic amines in non-irradiated sausages ranged between 125.50 and 596.18 mg/kgDW; irradiation with 4 and 6 kGy decreased said total contents to 105.20-94.82 and 104.98-26.44 mg/kgDW respectively, by the end of storage. Putrescine and cadaverine were the major amines in non-irradiated samples - where it accounted for 33% and 29% respectively, of the total by 90 days; however, tyramine dominated in irradiated samples with 2, 4 and 6 kGy, where it accounted for 44, 52 and 42%. On the other hand, the histamine content in non-irradiated sausage by 90 days of storage (i.e. 109.12 mg/kgDW) clearly exceeded the maximum allowable of 50 mg/kg, unlike happened in their irradiated counterparts. Therefore, the dramatic reduction observed in the histamine levels suggests use of this preservation technique for that traditional meat food. (author)

  1. Relevance of medieval, Egyptian and American dates to the study of climatic and radiocarbon variability

    International Nuclear Information System (INIS)

    Basic radiocarbon dating and dendrochronology have been combined to yield calibrated dates that are more accurate than conventional radiocarbon dates. This has been shown to be true for medieval and Egyptian dynastic dating. Because radiocarbon is a cosmogenically produced radioisotope, heliomagnetic and geomagnetic fields play a major role in its synthesis in the Earth's upper atmosphere. Inasmuch as a calibrated radiocarbon record exists for nearly 10 000 years, we now seem to possess in the short-time variations of the production rate a history of solar activity expressed via heliomagnetic fields carried by the solar wind. In turn, solar activity has a controlling effect on climate on Earth within modifications provided by the complex interactions of the atmosphere-Earth-ocean system. Both radiocarbon measurements and other empirical research methods agree on variations of climate during historically more recent periods on Earth. This leads to the suggestion that the radiocarbon calibration curve may be also a significant indicator or tracer for climatic changes for the Holocene or the Neolithic-Mesolithic. (author)

  2. Relevance of Medieval, Egyptian and American Dates to the Study of Climatic and Radiocarbon Variability

    Science.gov (United States)

    Berger, R.

    1990-04-01

    Basic radiocarbon dating and dendrochronology have been combined to yield calibrated dates that are more accurate than conventional radiocarbon dates. This has been shown to be true for medieval and Egyptian dynastic dating. Because radiocarbon is a cosmogenically produced radioisotope, heliomagnetic and geomagnetic fields play a major role in its synthesis in the Earth's upper atmosphere. Inasmuch as a calibrated radiocarbon record exists for nearly 10 000 years, we now seem to possess in the short-time variations of the production rate a history of solar activity expressed via heliomagnetic fields carried by the solar wind. In turn, solar activity has a controlling effect on climate on Earth within modifications provided by the complex interactions of the atmosphere-Earth-ocean system. Both radiocarbon measurements and other empirical research methods agree on variations of climate during historically more recent periods on Earth. This leads to the suggestion that the radiocarbon calibration curve may be also a significant indicator or tracer for climatic changes for the Holocene or the Neolithic-Mesolithic.

  3. Relevance of medieval, Egyptian and American dates to the study of climatic and radiocarbon variability

    Energy Technology Data Exchange (ETDEWEB)

    Berger, R. (California Univ., Los Angeles, CA (USA). Inst. of Geophysics and Planetary Physics)

    1990-04-24

    Basic radiocarbon dating and dendrochronology have been combined to yield calibrated dates that are more accurate than conventional radiocarbon dates. This has been shown to be true for medieval and Egyptian dynastic dating. Because radiocarbon is a cosmogenically produced radioisotope, heliomagnetic and geomagnetic fields play a major role in its synthesis in the Earth's upper atmosphere. Inasmuch as a calibrated radiocarbon record exists for nearly 10 000 years, we now seem to possess in the short-time variations of the production rate a history of solar activity expressed via heliomagnetic fields carried by the solar wind. In turn, solar activity has a controlling effect on climate on Earth within modifications provided by the complex interactions of the atmosphere-Earth-ocean system. Both radiocarbon measurements and other empirical research methods agree on variations of climate during historically more recent periods on Earth. This leads to the suggestion that the radiocarbon calibration curve may be also a significant indicator or tracer for climatic changes for the Holocene or the Neolithic-Mesolithic. (author).

  4. Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients

    Directory of Open Access Journals (Sweden)

    Walaa H Ahmed

    2013-01-01

    Full Text Available AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA polymorphism in Egyptian chronic hepatitis C virus (HCV patients. METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP of ITPA (rs1127354. SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon ? (PEG-IFN? as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV. The majority received PEG-IFN?2a (70.6% while 29.4% received PEG-IFN?2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2% had ITPA SNP CC genotype and 9 (8.8% had non-CC genotype (CA and AA. The percentage of hemoglobin (Hb decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P = 0.047 and 0.034, respectively. During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P = 0.024 and 0.038. Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P = 0.021. The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P = 0.044. Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P = 0.018, 0.009 and 0.026, respectively. CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients.

  5. MAJORITY MEASURES

    OpenAIRE

    Balinski, Michel; Laraki, Rida

    2015-01-01

    The validity of majority rule in an election with but two candidates—and of Condorcet consistency—is challenged. Axioms based on measures— paralleling those of K. O. May characterizing majority rule for two candidates that are based on comparisons—lead to another method. It is unique in agreeing with the majority rule when the electorate is “polarized” and meets R. A. Dahl’s requirement that an apathetic majority not defeat an intense minority. It accommodates any number of candidates and avo...

  6. Phenolics, Selenium, Vitamin C, Amino Acids and Pungency Levels and Antioxidant Activities of Two Egyptian Onion Varieties

    Directory of Open Access Journals (Sweden)

    Y.A. Elhassaneen

    2009-01-01

    Full Text Available Selenium, vitamin C, pungency, amino acids, phenolics content and antioxidant activities of two Egyptian onion varieties, namely white (Giza-6 and red (Beheri onions have been studied. Data analysis showed that the red variety presents higher values for selenium, vitamin C and sulphur-containing amino acids. Concerning pungency, white onion can be classified as intermediate pungency (8.24 ?mol of Pyruvic acid/100 g fresh wt. and red as pungent (11.37 ?mol of pyruvic acid/100 g fresh wt.. The phenolic acids, flavonols, anthocyanins and total phenolics content in red variety (81.59, 70.38, 7.56 and 187.17 mg/100 g fresh wt., respectively were higher than for white variety (72.47, 32.49, 4.90 and 131.65 mg/100 g fresh wt., respectively. Consequently, antioxidant activity was higher for the red variety. Correlation analysis indicates that phenolic compounds beside other factors including Se and sulphur-containing amino acid contents play the major role in the antioxidant activity of onion bulbs. The antioxidant capacity of freeze dried powder from both onion varieties was also tested in sunflower oil-in-water emulsions and hydroperoxide formation was monitored during storage at 40°C. In accordance with differences in Se, sulphur-containing amino acid and phenolics content, Egyptian red onions had better antioxidant activity, while white onions was only effective in the early stages of the oxidation process. These data indicates that red variety has higher potential health benefits related to the presence of antioxidant compounds.

  7. Clinico-pathological features of breast carcinoma in elderly Egyptian patients: A comparison with the non-elderly using population-based data

    International Nuclear Information System (INIS)

    Background: Breast cancer (BC) is a major worldwide health care problem that mostly afflicts the elderly population in the more developed countries. It is not known how common is breast cancer among elderly Egyptian patients and whether this differs from the disease in younger patients. Aims: To study the clinico-pathological features of BC in elderly Egyptian patients (>65 years of age) among the population of an Egyptian Governorate, Gharbiah, and to compare these features with those of younger patients ( < 65 years). Methods: This is a cross sectional study that compares elderly BC (EBC) and the non-elderly BC (NEBC) using the information from the Gharbiah Population-based Cancer registry (GPCR) during the years 1999-2007. Results: Out of 6078 BCs, 12% were EBCs and 88% were NEBCs. Between 1999 and 2007, the crude incidence rate (CIR, per 100,000 populations) of EBC increased from 47 to 71 and that of NEBC increased from 16 to 17. Compared to NEBC patients, EBC patients were more likely to have a positive family history and present with a distant disease and less likely to present with a localized disease. EBCs were more likely to have lung metastases and less likely to have liver metastases. Histology, grade, hormone and HER-2 receptor statuses were comparable in both groups Apart from hormonal therapies, the elderly were less likely to receive surgery, radiotherapy or chemotherapy. Conclusion: EBC patients in Egypt present with advanced disease and are less likely to receive surgery, radiotherapy or chemotherapy compared to NEBC patient

  8. Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

    Scientific Electronic Library Online (English)

    Manal Abdel Aziz, Hamed; Samia Abdel Aziz, Ahmed; Hussein Moustafa, Khaled.

    2011-05-01

    Full Text Available The schistosomal parasite plays a critical role in the development of malignant lesions in different organs. The pathogenesis of cancer is currently under intense investigation to identify reliable prognostic indices for disease detection. The objective of this paper is to evaluate certain biochemic [...] al parameters as diagnostic tools to efficiently differentiate between colonic carcinoma and colonic carcinoma associated with schistosomal infection among Egyptian patients. The parameters under investigation are interleukin 2 (IL-2), tumour necrosis factor alpha (TNF-?), carcinoembryonic antigen (CEA) levels, tissue telomerase, pyruvate kinase (PK), glucose-6-phosphate dehydrogenase (G-6-PD) and lactate dehydrogenase (LDH) enzyme activities. The results revealed a significant elevation in the level of the tumour markers IL-2, TNF-? and CEA as well as the activities of LDH, telomerase and G-6-PD among non-bilharzial and bilharzial colonic cancer groups, with a more potent effect in bilharzial infection-associated colonic cancer. A significant inhibition in PK activity was recorded in the same manner as compared to normal tissues. The efficacy of this biomarker was also evaluated through detecting sensitivity, specificity, negative and positive predictive values. In conclusion, schistosomal colonic carcinoma patients displayed more drastic changes in all parameters under investigation. The combination of the selected parameters succeeded in serving as biomarkers to differentiate between the two malignant types.

  9. Distribution of Fungi in the Sandy Soil of Egyptian Beaches

    Directory of Open Access Journals (Sweden)

    Fatma F. Migahed

    2003-01-01

    Full Text Available The mycobiota of the sandy soil of Egyptian beaches was investigated in thirty six sand samples collected from nine different localities in Egypt. The filamentous fungi were identified and assigned to thirty one genera and fifty one species. Greater populations as well as a wider spectrum range of fungal genera and species were obtained in sandy soil of Alexandria beach while Balteem beach was the poorest one. The total count of the genus or species did not always follow the number of cases of isolation. Most of the genera detected belonged to the Deuteromycotina with fewer proportions belonging to the Ascomycotina and Zygomycotina. The genera of highest incidence and their respective numbers of species were: Penicillium (35.72%, 6 spp. and Aspergillus (30.28%, 16 spp.. The species which showed the highest incidence in all cases was P. chrysogenum, followed by P. citrinum, A. flavus, Chaetomium murorum and Trichoderma viride. Several other genera and species were detected at quite low occurrence.

  10. Peanut sensitization in a group of allergic Egyptian children

    Directory of Open Access Journals (Sweden)

    Hossny Elham

    2011-05-01

    Full Text Available Abstract Background There are no published data on peanut sensitization in Egypt and the problem of peanut allergy seems underestimated. We sought to screen for peanut sensitization in a group of atopic Egyptian children in relation to their phenotypic manifestations. Methods We consecutively enrolled 100 allergic children; 2-10 years old (mean 6.5 yr. The study measurements included clinical evaluation for site of allergy, possible precipitating factors, consumption of peanuts (starting age and last consumption, duration of breast feeding, current treatment, and family history of allergy as well as skin prick testing with a commercial peanut extract, and serum peanut specific and total IgE estimation. Children who were found sensitized to peanuts were subjected to an open oral peanut challenge test taking all necessary precautions. Results Seven subjects (7% were sensitized and three out of six of them had positive oral challenge denoting allergy to peanuts. The sensitization rates did not vary significantly with gender, age, family history of allergy, breast feeding duration, clinical form of allergy, serum total IgE, or absolute eosinophil count. All peanut sensitive subjects had skin with or without respiratory allergy. Conclusions Peanut allergy does not seem to be rare in atopic children in Egypt. Skin prick and specific IgE testing are effective screening tools to determine candidates for peanut oral challenging. Wider scale multicenter population-based studies are needed to assess the prevalence of peanut allergy and its clinical correlates in our country.

  11. Synthesis of Cellulose Acetate Membrane from the Egyptian Rice Straws

    Directory of Open Access Journals (Sweden)

    Tamer I.M. Ragab

    2014-01-01

    Full Text Available In Egypt, approximately 4.5 million tons from 35 million tons of the annual production of recoverable cereal are disposed by burning and it creates a big problem. Isolation of cellulose with high yield and purity is a long-standing goal in cellulose development because of the complexity of cell wall structure of rice straw. Chemical composition of Egyptian rice straw was determined (moisture, ash, LMWC, wax and protein and total carbohydrates. Cellulose was extracted by different alkaline NaOH concentration till optimum conditions determined. A series of acetylated celluloses with various degrees of substitution were prepared by homogeneous acetylation of celluloses. The FT-IR, 1H NMR and 13C NMR were used to investigate the changes of chemical structures and physical characteristics. Three cellulosic membranes fabricated from cellulose acetate/polyethersulfone composite. The scanning electron microscope was measured and characterized by pore-free upper surface and a porous bottom surface. A water uptake ratio was measured at room temperature for three membranes of crude (M1, soluble acetone (M2 and soluble chloroform cellulose acetate (M3 as 708, 527 and 710% (w/w, respectively.

  12. Occupational radiation exposure in some Egyptian phosphate mines

    International Nuclear Information System (INIS)

    Radiation levels in some working phosphate mines in the Egyptian Eastern Desert have been investigated to estimate the occupational exposure to the workers in those sites. Such results may help in the preparation of the corrective actions as well as the improvement the safety measures if needed in those working mines. Beta and gamma levels as well as radon gas concentration and its decay products have been measured. Active techniques are employed to fulfill the objectives of measuring radon gas and its daughters. Some working conditions and environmental parameters such as the working time, type of available ventilation, temperature and humidity have been studied during the period of measurements. The maximum reported values for radon daughter concentration in units of working level are 1.28, in Safaga area south mine, 1.22 in Hamraween area B mine and 0.67 in El-Quser area Youns C mine. The maximum annual dose for the worker in all locations under investigation is about 100 mSv/y which is clearly much higher than the recommended international value. According to the above estimated values the question of ventilation economics in such mines is created. The classification of the miners in conventional mines as radiation workers should also be put into consideration. (author)

  13. Radiological responses of different types of Egyptian Mediterranean coastal sediments

    Energy Technology Data Exchange (ETDEWEB)

    El-Gamal, A., E-mail: ayman_elgamal@yahoo.co [Department of Oceanography, Coastal Research Institute, National Water Research Center, 15 Elpharaana St., Elshallalat, Postal code 21514, Alexandria (Egypt); Rashad, M. [Land and Water Technologies Department, Arid Land Cultivation and Development Research Institute, Mubarak City for Scientific Research, Burg El-Arab, Alexandria (Egypt); Ghatass, Z. [Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria (Egypt)

    2010-08-15

    The aim of this study was to identify gamma self-absorption correction factors for different types of Egyptian Mediterranean coastal sediments. Self-absorption corrections based on direct transmission through different thicknesses of the most dominant sediment species have been tested against point sources with gamma-ray energies of {sup 241}Am, {sup 137}Cs and {sup 60}Co with 2% uncertainties. Black sand samples from the Rashid branch of the Nile River quantitatively absorbed the low energy of {sup 241}Am through a thickness of 5 cm. In decreasing order of gamma energy self-absorption of {sup 241}Am, the samples under investigation ranked black sand, Matrouh sand, Sidi Gaber sand, shells, Salloum sand, and clay. Empirical self-absorption correction formulas were also deduced. Chemical analyses such as pH, CaCO{sub 3}, total dissolved solids, Ca{sup 2+}, Mg{sup 2+}, CO{sub 3}{sup 2-}, HCO{sub 3}{sup -} and total Fe{sup 2+} have been carried out for the sediments. The relationships between self absorption corrections and the other chemical parameters of the sediments were also examined.

  14. Gonadotropins studies in female egyptian subjects under different physiological conditions

    International Nuclear Information System (INIS)

    This study is concerned with the role of the hypothalamic hypophyseal regulatory hormonal mechanisms in the control of gonadal secretions in a selected normal egyptian female subjects with varying ages under different physiological conditions. The study allowed precise definition of the modulator influence of a number of key factors triggering appropriate alteration in circulating serum levels of FSH and LH determined by IRMA technique in pre-pubertal female children (9-11), post-pubertal adolescents females (13-16). Adult married females (27-33) and post-menopausal (58-63). The levels of FSH and LH were increased markedly with age but children less than 11 years old had only nocturnal increase in levels of FSH (p.O.I) and LH(P< 0.001). post-pubertal aged girls had significant nocturnal elevation only of LH levels (P< 0.001), adult married females did not exhibit significant difference in gonadotropin concentrations. whereas significant elevation in FSH and LH levels (P<0.001) in post-menopausal females were observed

  15. Effect of cholic acid on tumor in the Egyptian toad.

    Science.gov (United States)

    Sadek, I A

    1986-01-01

    Egyptian toads, Bufo regularis, were fed with cholic acid (sodium salt) 3 times/week for 12 weeks at different dose levels (2.5, 5, and 10 mg/toad). Results obtained showed only 1 case in both the 5 and 10 mg/toad doses that gave a tumor. Toads receiving N-methyl-N-nitrosourea (MNU) 1 mg/toad, 3 times/week for 12 weeks had 36% ileum tumors (18 toads out of 50, without mortality). On the other hand, a higher dose of MNU (5 mg/toad) caused 50% mortality in the experimental animals. Toads treated with MNU at a dose level of 1 mg/toad were subjected to CA at dose levels of 2.5, 5, 10 mg/toad. They showed a 48, 66 and 76% higher incidence of ileum tumors at the three different dose levels, respectively. It is concluded that cholic acid has a promoting effect on ileum tumor evoked by MNU in toads as in mammals. PMID:3725289

  16. Behaviour of uranium during processing of Egyptian monazite

    International Nuclear Information System (INIS)

    The present work deals with the study of the behaviour of uranium during alkaline processing of Egyptian monazite, followed by selective separation of thorium and uranium from lanthanides by leaching of the hydroxide cake with ammonium carbonate solutions. This method is based on the dissolution of thorium and uranium hydroxides in ammonium carbonate solutions in the form of soluble ammonium thorium and uranyl carbonate complexes, while the lanthanides hydroxides form sparingly soluble double carbonates. The obtained carbonate solutions, containing carbonate complexes of thorium and uranium are decomposed with steam in steel autoclaves. Uranium is completely recovered with thorium (99.7%) by alkaline processing of monazite concentrate in ball mill autoclaves at 1500C during 2.5 hours. The selective carbonate autoclave processing of hydroxide cake with ammonium carbonate-bicarbonate solutions show that high recovery of uranium (94.7%) with complete recovery of thorium (99.4%) and their separation from lanthanides are attained at 70-80oC, pressure 5-10 atm during 1h. The decomposition of carbonate complexes of thorium and uranium is favourably carried out in autoclaves at 120oC and steam pressure 2 atm during 10 min. Uranium is nearly completely recovered (98.4%) with thorium (99.8%) in the thorium concentrate produced. Meanwhile, the recovery of lanthanides is low and does not exceed 1.1%. The produced thorium concentrate contains 67.8% Th and 4.6% U. (author)

  17. Fast neutron fluxes distribution in Egyptian ilmenite concrete

    International Nuclear Information System (INIS)

    This work is concerned with the study of the distribution of fast neutron fluxes in a new type of heavy concrete made from Egyptian ilmenite ores. The neutron source used was a collimated beam of reactor neutrons emitted from one of the horizontal channels of the ET-RR-1 reactor. Measurements were carried-out using phosphorous activation detectors. Iso-flux curves were represented which give directly the shape and thickness required to attenuate the emitted fast neutron flux to a certain value. The relaxation lengths were also evaluated from the measured data for both disc monodirectional source and infinite plane monodirectional source. The obtained values were compared with that calculated using the derived values of relative number densities and microscopic removal cross-sections of the different constituents. The obtained data show that ilmenite concrete attenuates fast neutron flux more strongly than ordinary concrete. A semiemperical formula was derived to calculate the fast neutron flux at different thicknesses along the beam axis. Another semiemperical formula was also derived to calculate the fast neutron flux in ordinary concrete along the beam axis using the corresponding value in ilmenite concrete

  18. Barriers to E-Commerce Adoption in Egyptian SMEs

    Directory of Open Access Journals (Sweden)

    Abdel Nasser H. Zaied

    2012-07-01

    Full Text Available E-commerce has been predicted to be a new driver of economic growth for developing countries. The SME sector plays a significant role in its contribution to the national economy in terms of the wealth created and the number of people employed. Small and Medium Enterprises (SMEs in Egypt represent the greatest share of the productive units of the Egyptian economy and the current national policy directions address ways and means of developing the capacities of SMEs. Many factors could be responsible for the low usage of e-commerce among the SMEs in Egypt. In order to determine the factors that promote the adoption of e-commerce, SMEs adopters and non-adopters of e-commerce were asked to indicate the factors inhibiting the adoption of e-commerce. The results show that technical barriers are the most important barriers followed by legal and regulatory barriers, whereas lack of Internet security is the highest barrier that inhibit the implementation of e-commerce in SMEs in Egypt followed by limited use of Internet banking and web portals by SMEs. Also, findings implied that more efforts are needed to help and encourage SMEs in Egypt to speed up e-commerce adoption, particularly the more advanced applications.

  19. Major Links.

    Science.gov (United States)

    Henderson, Tona

    1995-01-01

    Provides electronic mail addresses for resources and discussion groups related to the following academic majors: art, biology, business, chemistry, computer science, economics, health sciences, history, literature, math, music, philosophy, political science, psychology, sociology, and theater. (AEF)

  20. Major Roads

    Data.gov (United States)

    Minnesota Department of Natural Resources — This data set contains roadway centerlines for major roads (interstates and trunk highways) found on the USGS 1:24,000 mapping series. These roadways are current...

  1. The Arab Spring and the Return Intention of Egyptians Living in Italy

    Directory of Open Access Journals (Sweden)

    Viviana Premazzi

    2013-12-01

    Full Text Available The widespread enthusiasm triggered by the Arab Spring affected both first- and second-generation Egyptians in Italy and led to different forms of action and socio-political participation. However, to what extent will this new enthusiasm transform into a real consideration of returning to Egypt is a largely unexplored topic. Relying on the main migration theories, we address the following research questions: which traditional theoretical arguments apply to the intention to return of first- and second-generation Egyptians in Italy? Do the changes in Egypt after the Arab Spring strengthen their intention to return? Presented data comes from qualitative interviews conducted between 2011–2013 with Egyptians in Turin and Rome. The results show that transnational ties strengthened by the Arab Spring support the idea of returning, although a definitive return will probably not occur for the first or for the second generation, but rather they will adopt a transnational way of living

  2. Effect of breeding conditions on thyroid and sex hormones of pregnant and lactating Egyptian buffaloes

    International Nuclear Information System (INIS)

    The present investigation was planned in order to clarify the effect of breeding conditions on the thyroid and sex hormones of Egyptian female buffaloes during gestation. Parturition and lactation. Serum levels of triiodothyronine (T3), thyroxine (T4), estradiol and progesterone were studied in two groups of buffaloes, aging 5-7 years.Starting from the 5th month of gestation till the 9th week of lactation. The first group was maintained on standard farm conditions and the second on ordinary traditional village conditions. The data revealed that the way of breeding has no effect on thyroid and sex hormones and no differences were observed. Accordingly, pregnancy and lactation were not affected. These results indicate that the Egyptian buffaloes have high adaptability towards the surrounding conditions so, its worthy to breed such beneficial animals without any additional effort or expenses. These factors should be considered for improving the Egyptian economy

  3. Verification of annual growth rings in Egyptian trees by C-14 method

    International Nuclear Information System (INIS)

    Annual growth rings in trees were thought to be due to sharp seasonal variations in the precipitation rates during the year. Accordingly temperature zone trees such as Egyptian trees were supposed to be away from this phenomenon. The temperature zones which are meant here are those of no sharp seasonal variations in the precipitation rates. The present study applied carbon-14 dating to prove that the growth rings in some Egyptian trees are annual. The method was based on the tropospheric measurements of C-14 during the period 1954-1981. C-14 exhibited a sharp peak resulting from the ever greater series of nuclear tests during 1963-1965. The presence of this peak for Egyptian trees proved that they form annual growth rings. (orig.)

  4. Dental affinities of the C-group inhabitants of Hierakonpolis, Egypt: Nubian, Egyptian, or both?

    Science.gov (United States)

    Irish, J D; Friedman, R

    2010-04-01

    By c. 2050 BC a small community of C-Group Nubians was present deep within Egyptian territory at the city of Hierakonpolis. Their descendants stayed for the next 400 years. Today, the site of Hierakonpolis, 113 km north of Aswan, is known for its Egyptian deposits; however, it also contains a C-Group cemetery, which documents the northernmost occurrence of this culture. Sixty skeletons were excavated. Tombs feature Nubian architecture and goods, including leather garments, although the use of Egyptian mortuary practices and artifacts increased through time. Dates range from the early 11th Dynasty into the Second Intermediate period. During this time the Egyptian empire occupied Lower Nubia, and their state ideology vilified Nubians. Yet, at least in death, the C-Group inhabitants of Hierakonpolis proudly displayed their cultural heritage. Beyond discerning the reason(s) for their presence at the site (e.g., mercenaries, leather-workers, entertainers?), the focus of this report is to estimate their biological affinity. Were they akin to other Nubians, Egyptians, or both? And, was increasing 'Egyptianization' evident in the mortuary ritual accompanied by concomitant genetic influence? To address these queries, up to 36 dental morphological traits in the recovered individuals were compared to those in 26 regional comparative samples. The most influential traits were identified and phenetic affinities were calculated using the mean measure of divergence and other multivariate analyses. Assuming phenetic similarity provides an estimate of genetic relatedness, these affinities suggest the individuals comprising the C-Group sample were, and remained Nubian during their tenure at Hierakonpolis. PMID:20185126

  5. LEU fuel element produced by the Egyptian fuel manufacturing pilot plant

    International Nuclear Information System (INIS)

    The Egyptian Fuel Manufacturing Pilot Plant, FMPP, is a Material Testing Reactor type (MTR) fuel element facility, for producing the specified fuel elements required for the Egyptian Second Research Reactor, ETRR-2. The plant uses uranium hexafluoride (UF6, 19.75% U235 by wt) as a raw material which is processed through a series of the manufacturing, inspection and test plan to produce the final specified fuel elements. Radiological safety aspects during design, construction, operation, and all reasonably accepted steps should be taken to prevent or reduce the chance of accidents occurrence. (author)

  6. Count like an egyptian a hands-on introduction to ancient mathematics

    CERN Document Server

    Reimer, David

    2014-01-01

    The mathematics of ancient Egypt was fundamentally different from our math today. Contrary to what people might think, it wasn't a primitive forerunner of modern mathematics. In fact, it can't be understood using our current computational methods. Count Like an Egyptian provides a fun, hands-on introduction to the intuitive and often-surprising art of ancient Egyptian math. David Reimer guides you step-by-step through addition, subtraction, multiplication, and more. He even shows you how fractions and decimals may have been calculated-they technically didn't exist in the land of the pharaohs.

  7. The Relationship between Employee Perceptions of Equity and Job Satisfaction in the Egyptian Private Universities

    Directory of Open Access Journals (Sweden)

    Mohamed Hossam El-Din KHALIFA

    2010-05-01

    Full Text Available The purpose of this study was to investigate the relationships between employee perception of equity and job satisfaction in the Egyptian private universities. Data were gathered using a face-to-face survey of 80 teaching staff members at three Egyptian universities. Findings revealed positive relationships between perceptions of equity, where a "motivator" was the outcome in the comparison, and job satisfaction. The study also revealed that there was no relationship between perceptions of equity and job satisfaction where a "hygiene factor" was the outcome in the comparison. This study is exploratory and findings are not conclusive. Its implications and limitations are discussed.

  8. Egyptian And International Automotive Diesel. Fuels: Specifications Meeting Challenges To Refining Industry

    International Nuclear Information System (INIS)

    This paper presents a brief summary and comparison of Egyptian automotive diesel fuel to the international one. Recent legislation all over the world, requiring further reduction in sulfur, aromatics, T90 and T95 and increasing cetane value of the transportation diesel fuels, presents numerous technical and economic challenges to the refiners. While refiners grapple with these challenges, they will also face pressure from the increased demand of transportation diesel fuel and tighter capital restrictions. Overcome of these challenges makes a fair competition. A comparison of the Egyptian automotive diesel fuel and the international one will be a guide to locally and globally facing these challenges

  9. Biochemical and physiological changes in Egyptian Nile fish subjected to varying levels of gamma irradiation

    International Nuclear Information System (INIS)

    Radiation is nowadays to be considered as a new parameter in the ecology of water masses. Aquatic organisms, perhaps more than any other group of organisms, are directly exposed to radiation hazard and may be subjected to continuous low-level exposure from bottom material and from internal sources accumulated within their own bodies, originating partly from radionuclides released from nuclear facilities into the aquatic environment. In recent years, a large number of papers have been published on the uptake, concentration and release of radioactive material by aquatic organisms. However, radiation experiments on fish, a major source of food for human consumption, are still very rare and mostly restricted to studies on the effect of irradiation on eggs and larvae. Since the study of the radiation effect on living aquatic organisms, particularly fish, is important in connection with the problems of preserving water resources for the benefit of mankind, the work presented here has been done to ascertain the effect of varying dose-levels of gamma irradiation on two common Egyptian Nile fish species, the catfish Clarias lazera and the Tilapia nilotica. Investigations carried out on Clarias lazera involved blood and muscle analyses as well as growth rate measurements. The results obtained showed impaired haematological levels, changes in weight of muscle proteins and, chiefly, retardation in growth rate. Investigations carried out on Tilapia nilotica revealed changes in the activity of certain digestive enzyme systems, glucose level in blood and concentration of the glycogen store in liver and muscles. In discussing the results obtained the authors have taken the relevant literature into consideration. (author)

  10. Indexing and Environmental Risk of Allergenic Protein Subunits of Egyptian Pollens

    Directory of Open Access Journals (Sweden)

    Abd El-Moneim M.R. AFIFY

    2014-06-01

    Full Text Available Four Egyptian pollen pellets: sunflower, clover, maize and broad beans, were evaluated for environmental risk of allergenic protein subunits, indexing amino acids, as well as nucleic acids contents. Protein fractions were subsequently extracted as albumin, globulin, urea and SDS-soluble proteins, by different methods. The results showed that albumin and globulin fractions represent the major constituents in different pollen pellets and amounted 33.24-40.3% and 32.57-37.22% respectively. SDS soluble protein showed minor amount. The electrophoretic separation of albumin and globulin extracts of sunflower pollen showed the presence of 8 protein subunits, which varied in their molecular weight between 4-67 KiloDalton (KDa; allergic protein subunits with MW 35 and 45 KDa were identified in all pollen pellets tested. Indexing and general analysis of the four pollen pellets showed that carbohydrates ranged from 28.12 (maize to 36.12 (sunflower, while total chlorophyll ranged from 5.85 (broad bean to 6.07 (maize mg/100 g fresh weight. It is also clear that the protein content of pollen pellets is above 40% and therefore they could be considered as a protein rich source. Broad bean pellets had the highest amount of protein content (48.31%. The lipid content ranged from 4.47 to 15.7%, according to pollen source. All pollen pellets contained relatively high quantities of RNA, which are nearly three times the equivalent of DNA content. Relative values of total free amino acids of four pollens were considerably low (below 20% and ranged from 2.93 ± 0.089 (sunflower to 15.99 ± 0.015 µmol/ mg fw.

  11. Prognostic Impact of Nucleophosmin 1 (NPM1 Gene Mutations in Egyptian Acute Myeloid Leukemia Patients

    Directory of Open Access Journals (Sweden)

    Magda Zidan

    2013-06-01

    Full Text Available OBJECTIVE: Somatic mutations of the nucleophosmin gene (NPM1, which alter the subcellular localization of the product, are the most frequent mutations in patients with acute myeloid leukemia. The aim of the study was to assess the prevalence and prognostic impact of NPM1 gene mutations in adult AML patients. METHODS: Polymerase chain reaction and single-strand conformation polymorphism (PCR-SSCP were used to screen 55 AML patients for mutations of NPM1 gene. RESULTS: NPM1 mutations were found in 12 (21.8% of 55 patients, significantly associated with higher total leukocytie count, marrow blast percentage (p=0.03 and p=0.02, respectively, and M5 subtype (p<0.001. Patients with NPM1 mutations had significantly higher complete remission rates (p=0.003 and a trend to lower rates of mortality, relapse and refractory disease (p=0.28, p=0.45 and p=0.08, respectively. Survival analysis showed significantly longer disease-free survival (mean 18.635±1.229 versus 11.041±1.250 months, p=0.044 and overall survival (mean 19.810±1.624 versus 12.063±1.244 months, p=0.041 in patients with NPM1 mutations compared with those without. Multivariate analyses confirmed NPM1 mutation as a significant independent predictor for disease-free survival (HR=0.066, p=0.001 and overall survival (HR=0.125, p=0.002. CONCLUSION: NPM1 mutation is a prognostic factor for a favorable outcome in Egyptian population. This finding is of major clinical importance since it strongly suggests that NPM1 mutations may allow one to divide the heterogeneous patient group of AML into prognostically different subgroups.

  12. The Restoration and Conservation of Egyptian Alabaster Vessels from the Early ERA in Atfiyah Museum Store - Helwan - Egypt

    Science.gov (United States)

    Radi Abdel Kader, R.; Sayed Mohamed, S.

    2013-07-01

    Egypt is considered one of the most countries which contain a lot of cultural heritage; the Ancient Egyptian used a lot of stones for his life like: limestone, sandstone, granite and Egyptian Alabaster. The Egyptian Alabaster is used for his daily and eternal life, he made a lot of funerary furniture from this stone like: vessels, statues, Architectural elements in the temples, tombs and canopic jars to preserve his viscera from decomposition like: stomach, liver … etc in the mummification process. Egyptian Alabaster is a sedimentary rock especially chemical- origin sedimentary rocks, it deposits inside caves and around springs which consists of calcium carbonates (CaCO3), they are very fragile "hardness = 3 in Mohs hardness scale". The Egyptian Alabaster vessels expose to a lot of deterioration factors in the burial and exposure environment after excavation. The study case vessels are made of Egyptian alabaster stone and belong to the early era (First and second Egyptian dynasties) in Atfiyah museum store, these vessels exposed to a lot of deterioration factors in the burial and exposure environment like: soil pressure, air temperature variety, relative humidity and salts. The vessels are conserved at the restoration laboratory in Atfiyah museum store by a lot of restoration and conservation processes like: cleaning - consolidation - assembling process for the separated parts and completion for the lost parts.

  13. Atypical mycobacterial cutaneous infections in Egyptians: a clinicopathological study.

    Science.gov (United States)

    El-Khalawany, Mohamed A

    2014-04-01

    Atypical mycobacteria comprise an uncommon heterogenous non-tuberculous group of acid-fast bacteria that rarely involve skin. The pattern of atypical mycobacterial cutaneous infections (AMCI) has not been previously studied in Egypt. The aim of this study was to describe the clinical characteristics, pathological features and species profile of AMCI among Egyptian patients. A retrospective study included 46 cases, diagnosed with AMCI during the period 2002 to 2012. The study included 34 males (73.9%) and 12 females (26.9%). The average age of patients was 39 years while the average duration of lesions was 15 months. The lesions were mostly located on the extremities (91.3%) and there was predominance of single (65.2%) and nodular (41.4%) lesions. History of trauma was confirmed in 91.3%. Histologically, the granulomas were mostly superficial (67.4%) with predominance of nodular suppurative pattern (84.8%). Other significant histological findings included epidermal hypertrophy (100%), presence of large-sized multinucleated giant cells (87%) and intrafollicular neutrophilic abscesses (84.8%). The diagnosis was proved by direct smear in 6.5%, skin biopsy in 10.9%, tissue culture in 47.8% and polymerase chain reaction (PCR) in 34.8%. Isolated species included Mycobacterium marinum (84.8%), Mycobacterium fortuitum (10.9%) and Mycobacterium kansasii (4.3%). Although the results of this study recommend that the diagnosis of AMCI is based mainly on culture and PCR, other clinicopathological features such as history of trauma, acral location of the lesion and suppurative granulomatous reaction with intrafollicular abscesses could be helpful clues in suspecting AMCI. PMID:24533920

  14. Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever

    Science.gov (United States)

    Salah, Samia; El-Masry, Sahar A; Sheba, Hala Fathy; El-Banna, Rokia A; Saad, Walaa

    2016-01-01

    Background: Familial Mediterranean fever (FMF) has episodic or subclinical inflammation that may lead to a decrease in bone mineral density (BMD). The objective of this study was to assess BMD in Egyptian children with FMF on genetic basis. Methods: A cross sectional study included 45 FMF patients and 25 control children of both sexes in the age range between 3-16 years old. The patients were reclassified into two groups, namely group I(A) with 23 cases using colchicine for 1 month or less, and group I(B) with 22 cases using colchicine for more than 6 months. For both the patients and control groups, MEFV mutations were defined using molecular genetics technique and BMD was measured by DXA at the proximal femur and lumbar spines. Results: Four frequent gene mutations were found in the patient group E148Q (35.6%), V726A (33.3%), M680I (28.9%), and M694V (2.2%). There were also four heterozygous gene mutations in 40% of the control children. Patients receiving colchicine treatment for less than 1 month had highly significant lower values of BMD at the femur and lumbar spines than the control children (P=0.007, P<0.001). Patients receiving colchicine treatment for more than 6 months had improved values of BMD at femur compared with the control, but there were still significant differences between them in lumbar spine (P=0.036). There were insignificant effect of gene mutation type on BMD and the risk of osteopenia among the patients. Conclusion: FMF had a significant effect on BMD. However, regular use of colchicine treatment improves this effect mainly at the femur. PMID:26722138

  15. Cytokine Gene Polymorphisms in Egyptian Cases with Brain Tumors

    International Nuclear Information System (INIS)

    Background: Cytokines are proposed to play important roles in brain tumor biology as well as neuro degeneration or impaired neuronal function. Objectives: This work aimed to check the association of polymorphisms of cytokine genes in Egyptian cases with brain tumors. Methods: This work included 45 cases affected by brain tumors diagnosed as 24 benign and 21 malignant. Their median age was 45 years, and they were 20 males and 25 females. These cases were taken randomly from the Neurosurgery Department of Mansoura University Hospital, Egypt. Case genotypes were compared to 98 healthy unrelated controls from the same locality. DNA was amplified using PCR utilizing sequence specific primers (SSP) for detection of polymorphisms related to TNF-a-308 (G/A), IL-10-1082 (G/A), IL-6-174 (G/C) and IL-1Ra (VNTR) genes. Results: Cases affected with benign brain tumors showed a significant higher frequency of IL-10-1082 A/A [odds ratio (OR=8.0), p<0.001] and IL-6-174 C/C (OR=6.3, p=0.002) homozygous genotypes as compared to controls. Malignant cases, on the other hand, showed significantly higher frequency of IL-6-174 C/C (OR =4.8, p=0.002) homozygous genotype and TNF-a-308 A/A (OR=4.9, p<0.001) homozygous genotype when compared to controls. In the meantime, all cases showed no significant difference regarding the distribution of IL-1Ra VNTR genotype polymorphism compared to controls. Conclusions: Cytokine gene polymorphisms showed a pattern of association with brain tumors which may have potential impact on family counseling and disease management.

  16. Structural Modification of Egyptian Kaolinite for Paper Coating

    International Nuclear Information System (INIS)

    The aim of this work is surface modification of Egyptian kaolinite for paper coating. Kaolinite < 2 fraction (KF) obtained using sedimentation and centrifuging techniques. Organo-kaolinite was prepared via inserting Urea (NH2 CO NH2) within the gallery of kaolinite using grinding technique for different times. Nano kaolinite was prepared from dispersion of organo-kaolinite in paper coating. The kaolinite (K), kaolinite /urea (KU) and kaolinite urea with binder (KU/Binder) were characterized using X-ray diffractometry (XRD), Infrared spectroscopy (IR) and Scanning Electron Microscopy (SEM). XRD studies revealed shifting of basal space of kaolinite from 0.714 to 1.11 nm upon grinding of kaolinite with urea for 5 h. On the other hand, the characteristic peak of kaolinite completely disappeared during dispersion of KU in paper coating suspension, which revealed the exfoliation of organo-kaolinite layers through the binder. Meanwhile, IR spectra show that NH-CO molecule exists in the intercalated kaolinite. The SEM images of KU revealed that kaolinite is intercalated U and fully exfoliation of KU achieved in KU/Binder and revealed by thin flakes with particle size ranged from 500 nm and 300 nm respectively. The modified kaolinite for paper coating increased the optical properties in terms of ISO brightness, opacity and gloss of the coated paper. There was a significant decrease in coated paper roughness compared to untreated kaolinite. Air permeance of the KF decreased in comparison with K sample, but increased sharply by intercalation of kaolinite (KU). Burst strength also started to increase with untreated kaolinite but decreased sharply with urea KU.

  17. Biological Assay of Toxoplasma gondii Egyptian Mutton Isolates

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    N.A. Hassanain

    2011-01-01

    Full Text Available Mutton signifies one of the most prevalent sources for human toxoplasmosis. However, sheep serological assays don't categorize the virulent strains initiating antibodies, so the biological bioassay of Egyptian mutton isolates with reference to their pathogenicity in both mice and kittens were done in this study for indicating to how extent their zoonotic bio-hazard. A total number of 280 of each sheep blood and tissue samples were collected during slaughtering at Cairo abattoir, Egypt. Sera assayed using Latex Agglutination Test (LAT and immunosorbant assay (ELISA and their corresponding mutton samples were microscopically examined after pepsin digestion for detection of Toxoplasma gondii infection. The sero-positive percent of the naturally infected sheep was 50.4 and 61.4 by LAT and ELISA, respectively, 47.9% of samples were confirmedly positive in both LAT and ELISA results. The microscopical examination revealed that only 28 out of 134 (20.9% of the confirmed sero-positive animals by both tests were found harboring T. gondii tissue cysts in their mutton samples, while high percentage of confirmed sero-positve animals (79.1% (106 out of 134 were biologically tissue cysts free mutton. Biological typing of the 28 T. gondii sheep isolates with reference to mice and kittens' bioassay indicated that 10.7, 50, 21.4 and 17.9% were type I, II, III and avirulent strains, respectively. The high T. gondii infection rate resulted in this study concludes that the feeding of under cooked mutton is a bad health habit as a source for human toxoplasmosis moreover; the T. gondii virulent strains obtained by mutton bioassay indicated that not all sero-positive sheep are connecting zoonotic bio-hazard through their mutton strains.

  18. A NEW SMALL POTATO PLANTER FOR EGYPTIAN AGRICULTURE

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    Ismail Z. Ebrahem

    2012-06-01

    Full Text Available Reducing the tuber period for potato plants by planting previously grown sprouts is a new technique. Applying this new agricultural methodology requires modification of the potato planter. The theoretical analysis was carried out to obtain information that can help avoid tuber damage during feeding and until it exits the feeding system. Starting from these considerations, a new potato planter with a spoon-based feeding system was designed and built. The tests conducted verified that the new system performed well when dividing tuber pieces into rows: considering the best growth spacing for potatoes is 20÷30 cm, the new system has a 68% distribution versus the 50,62 % of the old one. The tubers’ spacing in rows are evaluated based on tuber voids and tuber doubles. The results show that there is no difference between the two systems’ configurations, while a general consideration about our machine is that it is better at managing small tuber pieces. The void ratios are largely valid within the range of 0.4 up to 0.8 m/s of planted speeds; moreover, the results revealed that the tuber doubles decrease by increasing planting speed and vice versa with tuber voids. The quality of the potatoes planted is evaluated using the Shatter Index (SI %, which shows how the new configuration is more delicate with the tuber pieces (1.5 % against 17.5 % at 10 rpm or 46 % against 94 % at rpm 20. The new configuration could be an interesting improvement for potato quality and Egyptian potato production.

  19. Intestinal parasitic infection among Egyptian children with chronic liver diseases.

    Science.gov (United States)

    El-Shazly, Lerine Bahy El-Dine; El-Faramawy, Amel Abdel Magid; El-Sayed, Nagwa Mostafa; Ismail, Khadiga Ahmed; Fouad, Sally Mohammed

    2015-03-01

    Patients with chronic liver diseases (CLD) are often highly susceptible to parasitic infection due to a depressed immune system. The objective of this study was to detect the most commonly intestinal parasites found among Egyptian children with CLD. The present study was conducted on 50 children with CLD of different etiology (25 were having different intestinal symptoms, 25 without intestinal symptoms) and 50 non-CLD children with gastrointestinal complaints served as controls. All cases were subjected to stool examination and investigated by liver function tests. Also, anthropometric measurements were taken for all children including weight and height. It was found that the most commonly intestinal protozoa identified in the patients with CLD in order of frequency were: Entamoeba histolytica/Entamoeba dispar (16 %), Giardia lamblia (14 %), Blastocystis hominis (14 %), Cryptosporidium parvum (10 %), E. histolytica and G. lamblia (2 %), E. histolytica and B. hominis (2 %), G. lamblia and B. hominis (2 %), B. hominis and Entamoeba coli (2 %), Microsporidium (2 %) and no cases were found infected with Strongyloides stercoralis. As compared to the controls, the observed incidence of these organisms in CLD patients was significantly higher (p < 0.045) as regards stool examination by unstained techniques while, there was no significant difference between both groups as regards stool examination by stained techniques (p < 0.478). In addition, this study showed that the weight and height of studied patients were affected by parasitic infection while, there was no significant correlation between parasitic infection and liver function tests. In conclusion, chronic liver diseases affect the immunity of the patients as shown in significant increase in the incidence of intestinal parasites in cases compared to controls. PMID:25698851

  20. Thyroid disorders associated with alopecia areata in Egyptian patients

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    Ola A Bakry

    2014-01-01

    Full Text Available Context: Alopecia areata (AA is a common form of localized, non-scarring hair loss. The etiopathogenesis of the disease is still unclear, but the role of autoimmunity is strongly suggested. AA is commonly associated with various autoimmune disorders; the most frequent among them is autoimmune thyroid disorders. Aim: To determine whether AA is associated with thyroid autoimmunity or thyroid function abnormalities in Egyptian patients. Materials and Methods: Fifty subjects with AA (37 males and 13 females without clinical evidence of thyroid disorders were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital, Menoufiya Governorate, Egypt, during the period from June 2009 to February 2010. They were divided into 3 groups according to severity of AA. Fifty age and sex-matched healthy volunteers (35 males and 15 females were selected as a control group. Every case and control were subjected to history taking, complete general and dermatological examination. Venous blood samples were taken from cases and controls after taking their consents for measurement of thyroid stimulating hormone (TSH, free T3, freeT4 and detection of Anti-thyroglobulin Antibody (Tg-Ab and Anti-thyroid Peroxidase Antibody (TPO-Ab. Results: Subclinical hypothyroidism was detected in 16% of cases. There were statistically significant differences between cases and controls regarding levels of TSH, free T3 and free T4. There were significant differences between cases and controls regarding the presence of Tg-Ab and TPO-Ab. Conclusions: Every patient with AA should be screened for thyroid functions and presence of thyroid autoantibodies even in absence of clinical manifestations suggestive of thyroid affection.

  1. Grammatical Features of Egyptian and Palestinian Arabic Heritage Speakers' Oral Production

    Science.gov (United States)

    Albirini, Abdulkafi; Benmamoun, Elabbas; Saadah, Eman

    2011-01-01

    This study presents an investigation of oral narratives collected from heritage Egyptian and Palestinian Arabic speakers living in the United States. The focus is on a number of syntactic and morphological features in their production, such as word order, use of null subjects, selection of prepositions, agreement, and possession. The degree of…

  2. Cyber Uprising: Al-Jazeera TV Channel and the Egyptian Uprising

    Science.gov (United States)

    Rinnawi, Khalil

    2012-01-01

    This study will address the role of Arab transnational media in the Egyptian uprising. The main argument is that the emergence of the Arab satellite media in the region, such as al-Jazeera TV Channel and the Internet, has had a significant impact on the political and socio-cultural transformation in different Arab countries. It examines how the…

  3. Case Study of Professional Learning pan class="hlt">Community Characteristics in an Egyptian Private School

    Science.gov (United States)

    Kenoyer, Faith E.

    2012-01-01

    This case study of an Egyptian school sought to explore staff perceptions of which characteristics of a professional learning community, as posited by Hord (1997), were found in ABC School's culture. Educational staff (52 (100%)) completed the School Professional Staff as Learning Community Questionnaire (SPSLCQ) and 18 (35%) educational…

  4. Case Study of Professional Learning Community Characteristics in an Egyptian Private School

    Science.gov (United States)

    Kenoyer, Faith E.

    2012-01-01

    This case study of an Egyptian school sought to explore staff perceptions of which characteristics of a professional learning community, as posited by Hord (1997), were found in ABC School's culture. Educational staff (52 (100%)) completed the School Professional Staff as Learning Community Questionnaire (SPSLCQ) and 18 (35%) educational…

  5. Does Egyptian orange exports really have a market power in Saudi Arabia market?

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    Yasser S. A. Mazrou

    2015-07-01

    Full Text Available Egypt is one of the important orange exporters and Saudi Arabia also is an important import orange market. The Saudi orange market is a main market for Egypt which has a market share that exceeds half of Saudi orange market by 55.72%. This article aims to discover the degree of market power for Egyptian orange exports and other competitors in the Saudi market and if it is considered a measure of the relative mark- up by applying Residual Demand Elasticity approach. The results show that Egyptian orange exports has just a statistically signified market power by SUR and 3-SLS and has a negative sign, which may gain monopolistic profits by the relative mark-up over its marginal cost by about 63.7% without losing any of its market share. The source of Egyptian orange exports market power is due to: 1- product differentiation where Egypt exports navel orange most its export season compared with sweet orange which exported from other competitors. 2- Saudi Arabia Market demand characteristics which reflect on the consumers preference for Egyptian oranges.

  6. Web Usage Mining Analysis of Federated Search Tools for Egyptian Scholars

    Science.gov (United States)

    Mohamed, Khaled A.; Hassan, Ahmed

    2008-01-01

    Purpose: This paper aims to examine the behaviour of the Egyptian scholars while accessing electronic resources through two federated search tools. The main purpose of this article is to provide guidance for federated search tool technicians and support teams about user issues, including the need for training. Design/methodology/approach: Log…

  7. School-Based Management: An Approach to Decision-Making Quality in Egyptian General Secondary Schools

    Science.gov (United States)

    Elmelegy, Reda Ibrahim

    2015-01-01

    The current research aims at clarifying how school-based management (SBM) can contribute to achieve the decision-making quality in Egyptian general secondary schools and determine the requirements of quality decision-making. It depends on the descriptive method in order to acknowledge the basics of the SBM and its relationship with the quality of…

  8. Different Tools for the Assessment of Bone Mass among Egyptian Adults

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    Nayera E. Hassan

    2014-12-01

    CONCLUSION: DXA has been found to be more efficacious than QCT scan in the diagnosis of osteoporosis. DXA in femur is better than DXA-spine and QCT. Generally, DXA is the "gold standard" when assessing osteoporosis. Further studies are needed to modify the equation of OST and confirm its efficiency in Egyptians population.

  9. Traumatic injuries and imperialism: the effects of Egyptian colonial strategies at Tombos in upper Nubia.

    Science.gov (United States)

    Buzon, Michele R; Richman, Rebecca

    2007-06-01

    As circumstances of conquest change, leaders of empires must adapt their colonial strategies in order to be successful. One example of such modification in approach is the shift from Middle Kingdom to New Kingdom Egyptian colonial activities in Nubia. During the Middle Kingdom (2050-1650 BC) Egypt used aggressive military campaigns to subdue the strong Nubian polity at Kerma, resulting in the construction of fortresses and many victory stelae. In the subsequent New Kingdom period (1550-1050 BC) during which the Egyptian administration succeeded in occupying nearly all of Nubia, changes were necessary in conquest strategies. Diplomacy and cooperation may have replaced military action as mechanisms of control. This article investigates changes in imperial policy through the examination of traumatic injuries in human skeletal remains. Patterns of injuries in a sample from the site of Tombos, an Egyptian colonial cemetery in Nubia dating to the New Kingdom period, are compared with data on the patterns of injuries from Kerma, a cemetery dating to the Middle Kingdom period, published by Judd (2004). Analysis indicates a decrease in the level of traumatic injuries from Kerma to Tombos supporting the idea that through time the Egyptian administration modified their colonial strategy toward more nonviolent means. This article presents data on differences in the patterns of injury at Tombos and Kerma and explores possible explanations for this variation. PMID:17326101

  10. On the research activities in reactor and neutron physics using the first egyptian research reactor

    International Nuclear Information System (INIS)

    A review on the most important research activities in reactor and neutron physics using the first Egyptian Research Reactor (ET-RR-1) is given. An out look on: neutron cross-sections, neutron flux, neutron capture gamma-ray spectroscopy, neutron activation analysis, neutron diffraction and radiation shielding experiments, is presented

  11. Experimental Inoculation of Egyptian Rousette Bats (Rousettus aegyptiacus with Viruses of the Ebolavirus and Marburgvirus Genera

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    Megan E.B. Jones

    2015-06-01

    Full Text Available The Egyptian rousette bat (Rousettus aegyptiacus is a natural reservoir for marburgviruses and a consistent source of virus spillover to humans. Cumulative evidence suggests various bat species may also transmit ebolaviruses. We investigated the susceptibility of Egyptian rousettes to each of the five known ebolaviruses (Sudan, Ebola, Bundibugyo, Taï Forest, and Reston, and compared findings with Marburg virus. In a pilot study, groups of four juvenile bats were inoculated with one of the ebolaviruses or Marburg virus. In ebolavirus groups, viral RNA tissue distribution was limited, and no bat became viremic. Sudan viral RNA was slightly more widespread, spurring a second, 15-day Sudan virus serial euthanasia study. Low levels of Sudan viral RNA disseminated to multiple tissues at early time points, but there was no viremia or shedding. In contrast, Marburg virus RNA was widely disseminated, with viremia, oral and rectal shedding, and antigen in spleen and liver. This is the first experimental infection study comparing tissue tropism, viral shedding, and clinical and pathologic effects of six different filoviruses in the Egyptian rousette, a known marburgvirus reservoir. Our results suggest Egyptian rousettes are unlikely sources for ebolaviruses in nature, and support a possible single filovirus—single reservoir host relationship.

  12. Elemental concentrations in bones from an ancient Egyptian mummy and from a recent man

    International Nuclear Information System (INIS)

    Differences in elemental concentrations in bones taken from an ancient Egyptian mummy and a contemporary man were investigated by using proton induced x-ray emission (PIXE) in combination with Rutherford backscattering (RBS). Remarkable differences were noticed in the Fe/Ca and Pb/Ca relative concentrations, which were consistently higher in the contemporary man. 5 refs., 2 figs., 2 tabs

  13. Elemental concentrations in bones from an ancient Egyptian mummy and from a recent man

    Energy Technology Data Exchange (ETDEWEB)

    Cholewa, M.; Kwiatek, W.M.; Jones, K.W.; Schidlovsky, G.; Paschoa, A.S.; Miller, S.C.; Pecotte, J.

    1986-06-01

    Differences in elemental concentrations in bones taken from an ancient Egyptian mummy and a contemporary man were investigated by using proton induced x-ray emission (PIXE) in combination with Rutherford backscattering (RBS). Remarkable differences were noticed in the Fe/Ca and Pb/Ca relative concentrations, which were consistently higher in the contemporary man. 5 refs., 2 figs., 2 tabs.

  14. Exploring Egyptian EFL Students' Learning Styles and Satisfaction with Web-Based Materials

    Science.gov (United States)

    Aliweh, Ahmed Mahmoud

    2011-01-01

    Due to the increasing demand on the incorporation of web-based materials into Egyptian higher educational institutions, this study examined students' learning styles, satisfaction with online learning, and the relationships between these two variables and students' gender. The study was conducted on 51 EFL college students (24 males and 27…

  15. Analysis of Technical Specifications of the Egyptian and French Electronic Storybooks (e-Storybook)

    Science.gov (United States)

    Atta, Mohammed Mahmoud; Abd El Wahab, Shaimaa Mahmoud

    2015-01-01

    This research aims at analysing technical specifications in a sample of Egyptian and French electronic storybooks (e-storybooks), to identify similarities and differences in technical specifications of children's e-storybooks and create a verified analysis list to be used for evaluation of e-storybooks. For this purpose, 32 e-storybooks in CD…

  16. Cyber Uprising: Al-Jazeera TV Channel and the Egyptian Uprising

    Science.gov (United States)

    Rinnawi, Khalil

    2012-01-01

    This study will address the role of Arab transnational media in the Egyptian uprising. The main argument is that the emergence of the Arab satellite media in the region, such as al-Jazeera TV Channel and the Internet, has had a significant impact on the political and socio-cultural transformation in different Arab countries. It examines how the…

  17. Egyptian Court Overrules American University in Cairo's Limits on Religious Garb

    Science.gov (United States)

    Krieger, Zvika

    2007-01-01

    An Egyptian court ruled this month that the American University in Cairo could not bar a woman who wears the traditional niqab headdress from entering its library--the latest episode in the struggle between religion and secularism on Egypt's university campuses. The American University has outlawed the niqab--which covers the entire head except…

  18. More than a Facebook revolution: Social movements and social media in the Egyptian Arab Spring

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    Luis Fernando Barón

    2015-06-01

    Full Text Available Public opinion leaders and activists characterized the Egyptian “Arab Spring” of January 2011 as a “Facebook Revolution”. They highlight the intrinsic power of social media as an influencing factor for social change. Undeniably, social media played important roles in that revolution process. However, these roles cannot be disconnected from the socio-political contexts. This paper discusses the use of social media, particularly of Facebook, by the April 6th Youth Movement (A6YM, a decisive actor of the Egyptian protests. It is based on the analysis of two Egyptian newspapers and one American newspaper, between 2008 and 2011. We propose that a social media provided alternative mechanisms for political expression and organization, b social media contributed to the genesis and consolidation of the A6YM and to the establishment of youth political identities, and c the combination of “bits and streets” amplified not just the movement’s mobilization but the degree of opposition experienced by the Egyptian regime.

  19. Genetic drift. The ancient Egyptian dwarfs of the pyramids: the high official and the female worker.

    Science.gov (United States)

    Kozma, Chahira; Sarry El Din, Azza Mohamed; El Shafy El Banna, Rokia Abd; El Samie Kandeel, Wafaa Abd; Lachman, Ralph

    2011-08-01

    The existence of dwarfism is amply documented in ancient Egypt due to the rich biological and artistic legacies. In previous articles published in this journal, I discussed the roles of people with skeletal dysplasia in ancient Egyptian civilization. In this article I, along with my Egyptian and American colleagues, describe two skeletons of dwarfs that date to 2700-2184 BCE and were unearthed from a funerary complex near the Great Pyramids in Giza. The first skeleton belongs to a high official, Per-ni-ankh-w, who died between 45 and 50 years of age. His statue is on display in the Egyptian Museum of Cairo. The second skeleton belongs to a pregnant female worker found with a fetus in situ. Her estimated age at death was 25-30 years. She most likely died during childbirth due to a small pelvic outlet as supported by her narrow sacrum. The fetal bones appear normal. Radiological examination of both skeletons confirmed the clinical diagnosis of achondroplasia. Ancient Egyptians concerned themselves with the search for spiritual fulfillment through the tradition of moral teachings. Amenemope, a wise man who lived during the reign of Amenhotep III (1391-1354 BCE), advocated respect toward individuals with disabilities: Do not jeer at a blind man nor tease a dwarf, Neither interfere with the condition of a cripple. Do not taunt a man who is in the hand of God, Nor scowl at him if he errs. In summary, artistic, biological, and written resources indicate that dwarfs were well integrated in ancient Egyptian society. PMID:21674771

  20. Synthesis of calcium antimonate nano-crystals by the 18th dynasty Egyptian glassmakers

    Energy Technology Data Exchange (ETDEWEB)

    Lahlil, S.; Biron, I. [C2RMF, Centre de Recherche et de Restauration des Musees de France, Paris (France); Cotte, M. [C2RMF, Centre de Recherche et de Restauration des Musees de France, Paris (France); ESRF, European Synchrotron Radiation Facility, 6 rue Jules Horowitz, BP 220, Grenoble Cedex 9 (France); Susini, J. [ESRF, European Synchrotron Radiation Facility, 6 rue Jules Horowitz, BP 220, Grenoble Cedex 9 (France); Menguy, N. [Universites Paris 6 et 7, IMPMC, Institut de Mineralogie et de Physique des Milieux Condenses, Paris (France)

    2010-01-15

    During the 18th Egyptian dynasty (1570-1292 B.C.), opaque white, blue and turquoise glasses were opacified by calcium antimonate crystals dispersed in a vitreous matrix. The technological processes as well as the antimony sources used to manufacture these crystals remain unknown. Our results shed a new light on glassmaking history: contrary to what was thought, we demonstrate that Egyptian glassmakers did not use in situ crystallization but first synthesized calcium antimonate opacifiers, which do not exist in nature, and then added them to a glass. Furthermore, using transmission electron microscopy (TEM) for the first time in the study of Egyptian opaque glasses, we show that these opacifiers were nano-crystals. Prior to this research, such a process for glassmaking has not been suggested for any kind of ancient opaque glass production. Studying various preparation methods for calcium antimonate, we propose that Egyptian craftsmen could have produced Ca{sub 2}Sb{sub 2}O{sub 7} by using mixtures of Sb{sub 2}O{sub 3} or Sb{sub 2}O{sub 5} with calcium carbonates (atomic ratio Sb/Ca=1) heat treated between 1000 and 1100 C. We developed an original strategy focused on the investigation of the crystals and the vitreous matrices using an appropriate suite of high-sensitivity and high-resolution micro- and nano-analytical techniques (scanning electron microscopy (SEM), X-ray diffraction (XRD), TEM). Synchrotron-based micro X-ray absorption near edge spectroscopy ({mu}-XANES) proved to be very well suited to the selective measure of the antimony oxidation state in the vitreous matrix. This work is the starting point for a complete reassessment not only of ancient Egyptian glass studies but more generally of high-temperature technologies used throughout antiquity. (orig.)

  1. Evaluation of hemoglobinopathy screening results of a six year period in Turkey '

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    Seçil Gunher Ar?ca

    2012-02-01

    Full Text Available Background and Objectives: Hemoglobinopathies are autosomal recessive inherited diseases more commonly seen in Mediterranean countries. Hereditary blood diseases including B-thalassemia and sickle cell anemia are important health problems. In our study we aimed to analyze the results of the premarital hemoglobinopathy screening test for a 6 years period in Hatay region. Material and Methods: The study sample comprised the couples attending to the Mother and Child Health Care Center in Hatay for premarital hemoglobinopathy screening from 2004 to 2009. Hemoglobin chain analyses of 87.830 couples were evaluated. RESULTS: 175.660 people were screened at total. The prevalence of beta thalassemia trait, sickle cell anemia trait, sickle cell anemia, beta thalassemia major, beta-thalassemia intermedia, alpha-thalassemia, alpha-thalassemia trait was found as 13.921 (7,9%, 6.074 (3,4%, 631 (0.35%, 132 (0.07%, 118 (0.06%, 9 (0.005%, 150 (0.08% respectively. 72 newborns with beta-thalassemia were diagnosed as a result of the marriage of the carrier couples in 6 years. Conclusions: Hatay is a high risk region for beta-thalassemia and sickle cell anemia trait. In countries with high prevalence of hemoglobinopathies, a premarital screening program and counseling is needed to decrease the prevalence.

  2. Increasing the Working Capabilities of the Egyptian Scanning Landmine Detectors

    International Nuclear Information System (INIS)

    This work describes and discusses the developments which were performed to increase the potential uses of Egyptian Scanning Landmine Detectors, ESCALAD. The ESCALAD apply two nuclear techniques for allocation and identification of landmines buried in arid soil like landmine fields in Egypt. The first technique is based on measuring thermal neutrons backscattered from the soil and the second one is based on measuring gamma-rays emitted from elements of landmine interrogated by fast and thermal neutrons when the soil is irradiated by fast neutrons from Pu-α-Be sources. The developed systems with their associated detectors, neutron sources, measuring electronics and data analysis modules are mounted on an electrically driven trolley. The neutron backscattering NBS device detects landmines by the recognition of hydrogen density variation between explosive material, of a landmine and its surroundings, soil and other scattered objects. When a high energy neutron flux from Pu-α-Be sources penetrates the soil in which the landmine is buried, the neutrons undergo successive moderation processes until they come back with thermal energy. An array of two dimensional position sensitive thermal neutron detectors of 3He was used to monitor the backscattered thermal neutrons and for each neutron the position of hit along the tube with respect to the position on the ground is recorded. The elemental analysis technique is regarded as a complementary sensor of ESCALAD in which the gamma rays produced from fast/thermal neutrons interactions with the buried objects (i.e., a landmine) are measured. The measured response for gamma-rays is given as gamma ray spectrum. A mine is recognized through measuring the difference in the elemental composition, especially H, C, N and O. To increase the working capabilities of ESCALAD, different design mechanisms were developed for mount the detectors tray to overcome the effect of soil surface roughness and standoff distance on scanning capability. Also a more stable and reliable digital input/output computer board with high capacity was used. Moreover, more modified arrangements were applied for effective use of gamma detection sensor to have more efficient and rapid detection of mine constituent elements by fast and thermal neutron interrogation.

  3. Predictors of postpartum depression in a sample of Egyptian women

    Directory of Open Access Journals (Sweden)

    Saleh ES

    2012-12-01

    Full Text Available El-Sayed Saleh,1 Wafaa El-Bahei,1 Mohamed Adel El-Hadidy,1 Abdelhady Zayed21Psychiatric Department, 2Gynecological and Obstetric Department, Mansoura Faculty of Medicine, Mansura University, Mansoura, EgyptIntroduction: Postpartum depression (PPD represents a considerable health problem affecting women and their families. The aims of this study were to: (a compare female patients with PPD to normal controls with regard to some biopsychosocial variables, (b correlate between the severity of PPD and some clinical and biological variables, and (c to predict some risk factors for PPD.Method: Sixty female patients with PPD were compared with 60 healthy postpartum females (control group. Patient and controls were subjected to: (1 a complete psychiatric and obstetric examination, (2 psychometric studies using the Edinburgh Postnatal Depression Scale, Fahmy and El-Sherbini's Social Classification Scale for Egyptian socioeconomic classification and Horowitz et al's Impact of Event Scale, (3 quantities of thyroid hormone (T3, cortisol hormone, and estrogen were assessed.Results: There were high statistical differences between PPD females and controls as regard psychosocial stressors, level of (estradiol, thyroxin [T3], and cortisol, marital status, residence, parity, method of delivery, complicated puerperium, positive history of premenstrual tension syndrome and baby variables (eg, unwelcomed, with a negative attitude of parents toward the baby, underweight, female, artificially feeding, unhealthy baby. While there were moderate statistical differences in attitude toward spouse and social support and mild statistical difference in socioeconomic status between them. Severity of depression is positively highly correlated with onset of depression, psychosocial stress, levels of T3 and cortisol. However, severity of depression is negatively high when correlated with socioeconomic status. Stepwise linear regression indicated that PPD was significantly predicted by social support, socioeconomic status, feeding of baby, and prior psychiatric problems.Conclusion: Many factors may lead to development of PPD. These factors include some psychosocial, socioeconomic, obstetric, and hormonal variables. Early detection of these factors could help in prediction of the development of PPD.Keywords: mood, hormone, delivery, socioeconomic

  4. On the astronomical orientation of the IV dynasty Egyptian pyramids and the dating of the second Giza pyramid

    OpenAIRE

    Magli, Giulio

    2003-01-01

    The data on the astronomical orientation of the IV dynasty Egyptian pyramids are re-analyzed and it is shown that such data suggest an inverse chronology between the `first` and the `second` Giza pyramid.

  5. A suggested proposal to develop a knowledge-based economy in Egyptian universities in light of some international experience

    OpenAIRE

    Antar Mohammed Ahmed Abdel Aal

    2013-01-01

    The Problem of this study can be formulated in need management Egyptian universities to develop the knowledge economy, Thus the main objective of this study is to provide decision-makers in the Egyptian universities envision a proposal which would contribute to the development of knowledge-based economy. To achieve this objective descriptive approach was used.This study has many resulted in the light of these results put a number of recommendations:1. Transform the university into a center of...

  6. Co-inheritance of novel ATRX gene mutation and globin (? & ?) gene mutations in transfusion dependent beta-thalassemia patients.

    Science.gov (United States)

    Al-Nafie, Awatif N; Borgio, J Francis; AbdulAzeez, Sayed; Al-Suliman, Ahmed M; Qaw, Fuad S; Naserullah, Zaki A; Al-Jarrash, Sana; Al-Madan, Mohammed S; Al-Ali, Rudaynah A; AlKhalifah, Mohammed A; Al-Muhanna, Fahad; Steinberg, Martin H; Al-Ali, Amein K

    2015-06-01

    ?-Thalassemia X-linked mental retardation syndrome is a rare inherited intellectual disability disorder due to mutations in the ATRX gene. In our previous study of the prevalence of ?-thalassemia mutations in the Eastern Province of Saudi Arabia, we confirmed the widespread coinheritance of ?-thalassemia mutation. Some of these subjects have a family history of mental retardation, the cause of which is unknown. Therefore, we investigated the presence or absence of mutations in the ATRX gene in these patients. Three exons of the ATRX gene and their flanking regions were directly sequenced. Only four female transfusion dependent ?-thalassemia patients were found to be carriers of a novel mutation in the ATRX gene. Two of the ATRX gene mutations, c.623delA and c.848T>C were present in patients homozygous for IVS I-5(G?C) and homozygous for Cd39(C ? T) ?-thalassemia mutation, respectively. While the other two that were located in the intronic region (flanking regions), were present in patients homozygous for Cd39(C ? T) ?-thalassemia mutation. The two subjects with the mutations in the coding region had family members with mental retardation, which suggests that the novel frame shift mutation and the missense mutation at coding region of ATRX gene are involved in ATRX syndrome. PMID:25976463

  7. Chemical, Nutritional and Microbiological Evaluation of Some Egyptian Soft Cheeses

    Directory of Open Access Journals (Sweden)

    *Ghada, Z. A. A., 2*Alia, M. H., 3**Soha, Al-S., 4*Magdy, N. A., and 5*Mohammed, F. S

    2004-12-01

    Full Text Available Milk and dairy products is considered the most complete foodstuff that provide human either infants or adults with most of their vital needs. Milk and cheese have high nutritive value due to its high content of protein, fat, minerals especially calcium (Ca2+ & phosphorous, and vitamins. Two hundred samples produced and sold in Egypt during 2001-2003 were collected from allover the country. The cheese samples were subjected to microbiological and chemical analysis. Samples were microbiologically tested for total aerobic bacterial count (TABC, Colifrm, Escherichia coli (E. coli, Staphylococcus aureus, mould and yeast, salmonella and shigella, and listeria species. Protein, fat, carbohydrates, moisture, ash, lactose, Calcium (Ca, phosphorous (P and Ca/P were evaluated. The analysis showed that total aerobic bacterial count did not exceed 1.4X105±1.7X105 cells/gm, which is close to what allowed by the Standard Egyptian Guidelines (2001 and 47.5 % of the tested cheese are free from coliform bacteria and Escherichia coli. Ninety-eight and half percent, 97 %, 97 % and 91.5 % of the tested cheese (kareish, feta, thalaga, double cream respectively, either made in plant or home or farmers' cheese sample have zero Staphylococcus aureus count or mould and yeast; or salmonella and shigella, or listeria species respectively, i. e. free from them. Double cream cheese has the lowest protein content (7.79±0.78 gm% while kareish cheese has the highest protein content (19.99±1.32 gm%, but for fat content the opposite is true, double cream cheese have the highest fat content (24.56±1.78 gm% while kareish cheese have the lowest fat content (3.87±0.97 gm %. Feta cheese has high ash content while kareish cheese has the highest moisture content with the lowest ash content (68.97±1.86 & 1.81±0.47 gm% respectively. Lactose content varies widely from 1.50±0.26 (double cream cheese to 3.25±0.50 (feta cheese. Kareish cheese has higher content of calcium and phosphorous (641.1±49.21 mg%, 431.18±37.21 mg% respectively than the remaining types of cheese. Calcium & phosphorous content of kareish cheese is almost the double content of the double cream cheese. Feta cheese has higher Ca/P (1.65±0.19 while thalaga and double cream has lower Ca/P (1.34±0.13 & 1.37±0.20. Each 100 gm of soft cheese can provide children (1-8 y & adult (9-50 y from 39.78% & 24.48 % to128.22 % & 64.11% of their Ca Dietary Reference Intake and this from double cream cheese and kareish cheese respectively.

  8. The Impact of Diabetes on Serum Osteocalcin in Egyptian Children

    International Nuclear Information System (INIS)

    Diabetes may affect bone via bone structure, bone density, and biochemical markers of bone turnover. Lack of diagnosis and treatment of alterations of the bone tissue metabolism in type1diabetes (T1D) may lead to osteoporosis.T1D most often starts before achieving peak bone mass.Recent studies have revealed that, in T1D fracture risk is increased more than expected from the degree of decrease in bone mineral density (BMD).Osteocalcin (OC) is considered a useful biochemical marker of bone formation. As in T1D, there is absolute insulin deficiency but insulin sensitivity remains generally intact. Therefore, this study was conducted to evaluate the association between OC levels in relation the degree of residual β-cell function and other metabolic parameters in T1D In the present study, the impact of diabetes on serum OC in Egyptian children and adolescents was evaluated by comparing serum level of OC in T1D (30 subjects) and age-matched non-diabetic control (15 subjects). The present study showed that, patients with T1D had lower OC serum levels compared to the controls (7.67 ± 3.55, 21.82 ± 4.96 μg/ml respectively, p < 0.001) with a lower OC levels in diabetic females than in diabetic males (5.92 ± 3.12, 8.74 ± 2.84 μg/ml respectively, p < 0.001) and lower OC levels in pre-pubertal than pubertal diabetic patients in both genders with p < 0.05. Serum OC levels in T1D correlated with HbAIc (p < 0.001), BMI (p < 0.05), durations of T1D (p < 0.05) and total daily insulin dose (p < 0.05)and did not correlate with C-peptide levels . It may be concluded that serum OC levels in patients with T1D are regulated by a variety of developmental and metabolic pathways. Since OC levels correlated with exogenous insulin(daily insulin dose) and did not correlate with endogenous insulin (C-peptide levels), therefore, it is presumed that OC was regulated by insulin-mediated events, in presence of aggressive autoimmune destruction of pancreatic cell. These results proposed that the decrease in serum levels of OC can be considered one of the important causes of degraded bone metabolism in children and adolescents suffering from TID and OC levels related to metabolic control of diabetes. From this study, it could be concluded that patients with T1D have low levels of OC and may be exposed at adolescence to the risk of osteopenia. Thus, it is recommended that early efficient metabolic control and efficient treatment are important to prevent osteoporosis in later life. Researches in the future may be done to know if it is possible to give OC to diabetic children as supplemented treatment to prevent osteopenia later in life. Keywords diabetes, Serum osteocalin, Body mass index, HbIAc, C-peptide.

  9. THE GENIUS LOCI AT THE GREAT TEMPLE OF ABU SIMBEL: HERMENEUTIC READING IN THE ARCHITECTURAL LANGUAGE OF ANCIENT EGYPTIAN TEMPLES OF RAMSES II IN NUBIA

    Directory of Open Access Journals (Sweden)

    Nelly Ramzy

    2015-06-01

    Full Text Available Archaeologists have long wondered about the Temple of Abu Simbel: its location within the Nubian territory far from major Egyptian cities, and its unique design. Utilizing the hermeneutic process of understanding the whole from the parts and then situating the whole within a bigger whole (context, this study is a trial to arrive at a better interpretation of this monument. Drawing on the characteristic analysis of the temple's Genius Loci as developed by Norberg-Schulz, as well as on Heidegger's anticipatory fore-structures, the study goes on to show that both of the location and the unique structure of the temple were the outcome of political and conceptual aspects of the period, more than being a religious tradition. Reaching this conclusion, another goal had been achieved, where the validity of hermeneutic analyses as a useful tool for discovering new dimensions about historical monuments and archaeological sites had been attested.

  10. The Prevalence of Vitamin D Deficiency in Ancient Egyptian Population from Baharia Oasis, the Greco Roman Period

    Directory of Open Access Journals (Sweden)

    Rokia Abd ElShafy Soliman El-Banna*, , Azza Mohamed Sarry El-Din*, Fatma Ahmed Eid**, Walaa Yousef Mohamed Ali

    2014-04-01

    Full Text Available Background: Vitamin D deficiency is considered to be the most common nutritional deficiency and also one of the most common undiagnosed medical conditions in the world. Vitamin D is naturally present only in minor amounts in most foods; the great majority is synthesized by the action of ultraviolet light on chemical precursors in the skin. The manifestation of vitamin D deficiency in sub adults is referred to as rickets, and in adults, osteomalacia . Rickets and osteomalacia are the sub adult and adult expressions of a disease in which the underlying problem is a failure to mineralize bone protein (osteoid. The most common cause of this disease is a physiological deficiency in vitamin D. The associated problems include deformed bones. Material and Methods: This study aimed to investigate the skeletal remains of ancient Egyptians from Baharia Oasis population for lesions indicative of vitamin D deficiency (rickets and osteomalacia. The material consisted of 1075 commingled bones (38 sub adults and1037 adults. They were recovered from Baharia oasis. Results: The results showed that, there was no evidence of rickets in sub adult group. The prevalence of osteomalacia in adult Baharia populations was 7.4% ; all were adult males. This result could indicate that this population was subjected to sunlight all over the year and their diet was rich of calcium and phosphorus. Conclusion: These few cases that were found may be due to mechanical stress during wine and textile production.

  11. Biodegradation ability and catabolic genes of petroleum-degrading Sphingomonas koreensis strain ASU-06 isolated from Egyptian oily soil.

    Science.gov (United States)

    Hesham, Abd El-Latif; Mawad, Asmaa M M; Mostafa, Yasser M; Shoreit, Ahmed

    2014-01-01

    Polycyclic aromatic hydrocarbons (PAHs) are serious pollutants and health hazards. In this study, 15 PAHs-degrading bacteria were isolated from Egyptian oily soil. Among them, one Gram-negative strain (ASU-06) was selected and biodegradation ability and initial catabolic genes of petroleum compounds were investigated. Comparison of 16S rRNA gene sequence of strain ASU-06 to published sequences in GenBank database as well as phylogenetic analysis identified ASU-06 as Sphingomonas koreensis. Strain ASU-06 degraded 100, 99, 98, and 92.7% of 100?mg/L naphthalene, phenanthrene, anthracene, and pyrene within 15 days, respectively. When these PAHs present in a mixed form, the enhancement phenomenon appeared, particularly in the degradation of pyrene, whereas the degradation rate was 98.6% within the period. This is the first report showing the degradation of different PAHs by this species. PCR experiments with specific primers for catabolic genes alkB, alkB1, nahAc, C12O, and C23O suggested that ASU-06 might possess genes for aliphatic and PAHs degradation, while PAH-RHD?GP gene was not detected. Production of biosurfactants and increasing cell-surface hydrophobicity were investigated. GC/MS analysis of intermediate metabolites of studied PAHs concluded that this strain utilized these compounds via two main pathways, and phthalate was the major constant product that appeared in each day of the degradation period. PMID:25177681

  12. Patterns of ovarian and oestrous activity and induction of cyclic activity during the post-partum period in Egyptian buffaloes

    International Nuclear Information System (INIS)

    This report covers three studies. In the first study, ovarian and oestrous activity were monitored in 47 buffaloes for 90 days following parturition. Failure to resume ovarian cyclicity after calving was found to be the main reason for the delay in conception. High incidence of ovulatory anoestrus (64%) constitutes also a major problem in Egyptian buffaloes. In the second study, buffaloes with inactive ovaries were treated at 90 days post-partum with either GnRH or progesterone, given either intravaginally (PRID) or orally (CAP). Both GnRH and PRID were effective in inducing ovulation but GnRH administration was followed by a high incidence of silent ovulation. Within the 35 days following treatment, about 50% of the PRID treated animals got in calf vs. 44 and 22% for GnRH and CAP treated animals, respectively. In the third study, buffaloes were treated with either 6 or 12?g GnRH at either 7 or 15 days post-partum. GnRH treatment resulted in significant reductions in the intervals from calving to first ovulation, first detected oestrus and time to first rise in serum progesterone concentration (> 1 ng/mL). (author). 26 refs, 5 figs, 4 tabs

  13. Age distribution, polyps and rectal cancer in the Egyptian population-based cancer registry

    Directory of Open Access Journals (Sweden)

    Darlene Veruttipong

    2012-01-01

    Full Text Available AIM: To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS: The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007. All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted: age, residence, diagnosis date, grade, stage, topology, clinical characteristics, and histology variables. Egyptian census data for 1996 and 2006 were used to provide the general population’s statistics on age, sex, residence and other related demographic factors. In addition to age- and sex-specific incidence rate analyses, we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the province. We also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results (SEER data of the United States. RESULTS: Over the 9 year-period, 1364 colorectal cancer cases were included. The disease incidence under age 40 years was relatively high (1.3/105 while the incidence in the age groups 40 and over was very low (12.0/105, 19.4/105 and 21.2/105 in the age groups 40-59 years, 60-69 years and > 70 years, respectively. The vast majority of tumors (97.2% had no polyps and 37.2% of the patients presented with primary lesions in the rectum. Colorectal cancer was more common in patients from urban (55% than rural (45% areas. Regional differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this population. The registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 years. The results also shows significantly lower incidence of colorectal cancer in subjects over age 40 years compared to the same age group in the United States SEER. CONCLUSION: Low rate of polyps, low incidence in older subjects, and high rate of rectal cancer in Egypt. Future studies should explore clinical and molecular disease patterns.

  14. General description and production lines of the Egyptian fuel manufacturing pilot plant

    International Nuclear Information System (INIS)

    The Egyptian Fuel Manufacturing Pilot Plant, FMPP, is a new facility, producing an MTR-type fuel elements required for the Egyptian Second Research Reactor, ETRR-2, as well as other plates or elements for an external clients with the same type and enrichment percent or lower, (LEU). General description is presented. The production lines in FMPP, which begin from uranium hexaflouride (UF6, 19.7±0.2 % U235 by wt), aluminum powder, and nuclear grade 6061 aluminium alloy in sheets, bars, and rods with the different heat treatments and dimensions as a raw materials, are processed through a series of the manufacturing, inspection, and quality control plan to produce the final specified MTR-type fuel elements. All these processes and the product control in each step are presented. The specifications of the final product are presented. (author)

  15. An Empirical Comparison of Tree-Based Learning Algorithms: An Egyptian Rice Diseases Classification Case Study

    Directory of Open Access Journals (Sweden)

    Mohammed E. El-Telbany

    2016-01-01

    Full Text Available Applications of learning algorithms in knowledge discovery are promising and relevant area of research. The classification algorithms of data mining have been successfully applied in the recent years to predict Egyptian rice diseases. Various classification algorithms can be applied on such data to devise methods that can predict the occurrence of diseases. However, the accuracy of such techniques differ according to the learning and classification rule used. Identifying the best classification algorithm among all available is a challenging task. In this study, a comprehensive comparative analysis of a tree-based different classification algorithms and their performance has been evaluated by using Egyptian rice diseases data set. The experimental results demonstrate that the performance of each classifier and the results indicate that the decision tree gave the best results.

  16. Internal radiation dose in egyptian population from radio-contaminated foods after Chernobyl accident

    International Nuclear Information System (INIS)

    The average overall dose intake by the egyptian person, per Bq for food contaminated with 134 Cs and 137 Cs, was computed using a simple mathematical model. These calculations showed that this dose is; on the average; 0.04 ? Sv as internally absorbed dose due consumption of 1 Bq of 134 Cs + 1 Bq 137 Cs. Using the evaluated radiation levels in the imported foodstuff and the mathematically calculated annual dose per Bq, the total dose to a person, daily fed with egyptian traditional food items in one year,was computed and found to be 1.105 x 10-3 to 8.372 x 10-3 Sv with an average level of 4.7387 10-3 Sv

  17. Prevalence of bone marrow necrosis in Egyptian cancer patients referring to the National Cancer Institute

    International Nuclear Information System (INIS)

    Bone marrow necrosis; Egyptian cancer patients Abstract Background: Bone marrow necrosis is a relatively rare entity which has been associated with a poor prognosis. It is most commonly found in patients with neoplastic disorders and severe infections. Methods: study comprised examination of 5043 bone marrow biopsy specimens performed at the National Cancer Institute, Cairo University, over 7 years period (March 2004-March 2011). It included 5 years retrospective (2867 archived samples) and 2 years prospective (2176 samples). Results: Bone marrow necrosis was diagnosed in fifteen out of 5043 examined specimens with a percentage of 0.3% and ranged from mild to massive according to semiquantitative estimation. Prognosis of all patients was poor with survival not exceeding 6 months from the date of marrow necrosis diagnosis. Conclusion: In Egyptian patients, bone marrow necrosis in association with malignancy is a rare disorder which is accompanied by a poor outcome

  18. Behaviour of some acid-base indicators in some Egyptian aquatic environments

    International Nuclear Information System (INIS)

    The dissociation constants of some selected acid-base indicators (methyl red, bromothymol blue, bromo cresol green) were evaluated in some Egyptian aquatic environments. The studied regions included marine (seven sites along the Egyptian Mediterranean coast from Abu-Qir east of Alexandria to the region of 21 km west of Alexandria), lakes (Mariut, Edku, and Burullus) and the drainage system around Alexandria (El-Kalaa, El-Umum, Barsiek and El-Khairy Drains and El-Noubaria Draining canal). Two samples were collected from the fishing ponds El-Nozha Hydrodrome and El-Mex. Some physical and chemical characteristics of the aquatic systems were determined and discussed. The behavior of the indicators is correlated with their structure and the status of the environment. (Author)

  19. Compensating Differentials and the Value of Job Security: Evidence from the Egyptian Public Sector

    OpenAIRE

    Mona Said

    2011-01-01

    This paper considers the determinants of male and female pay in the public and private sectors by estimating a joint model of sector allocation and wage determination using cross-sectional data from the Egyptian 1987 and 1997 labour force surveys. A model of compensating wage differentials is defined and estimated, in order to quantify the value of arguably the three most important non-pecuniary aspects of public sector employment: job security, fringe benefits (especially comprehensive retir...

  20. Protozoa in a stressed area of the Egyptian Mediterranean coast of Damietta, Egypt

    OpenAIRE

    Mohamed Moussa Dorgham; Wael Salah El-Tohamy; Nagwa Elsayed Abdel Aziz; Ahmed El-Ghobashi

    2013-01-01

    The Damietta coast is part of the Egyptian Mediterranean coast off the Nile Delta and has recently been polluted as a result of intensive human activities.The environmental parameters and protozoan community in the area were studied biweekly from January to December 2007. The results of the environmentalparameters indicated low salinity, oxic and anoxic conditions, high nutrient levels and intensive phytoplankton growth. A total of 69 protozoan specieswere identified, belonging to Amoebozoa (...

  1. The Database of Egyptian Building Envelopes (DEBE): A database for building energy simulations

    OpenAIRE

    Attia, Shady; Wanas, O.

    2012-01-01

    This paper is a part of an ongoing research that aims to describe the influence of building constructions on energy consumption through a survey that is conducted in Cairo and its surrounding residential neighbourhoods. An inventory of the selected neighbourhoods envelope constructions and their characteristics is described in accordance with the new Egyptian energy standard for residential buildings. After thorough screening and classification, the constructions are digitalized and uploa...

  2. Men in the Picture: Representations of Men and Masculinities in Egyptian Cinema since 1952.

    OpenAIRE

    Van Eynde, Koen

    2015-01-01

    Research of men and masculinities in the Middle East and North Africa remains scarce, to say the least. Only occasionally and irregularly researchers pay attention to the topic, while gender studies in the region continues to focus on women. Nevertheless, the term gender incorporates more than just women. In practice, however, we find little information on Egyptian and Arab men and masculinities.This lack is partly explained by the interests of gender studies in this specific geographic regio...

  3. A rapid instrumental neutron activation method for multielement content of some Egyptian phosphate minerals

    International Nuclear Information System (INIS)

    An instrumental neutron activation analysis technique has been applied to some Egyptian phosphate minerals. The following 24 elements have been quantitatively determined. Sc, Cr, Fe, Co, As, Sr, Zr, Nb, Ag, Sn, Te, Ba, La, Ce, Nd, Eu, Tb, Ho, Yb, Lu, Hf, Ta, Ir and U. The observed distribution and abundance of some of the above elements could help in the proper evaluation of conditions of deposition and origin of their phosphate minerals

  4. First insights into the metagenome of Egyptian mummies using next-generation sequencing.

    Science.gov (United States)

    Khairat, Rabab; Ball, Markus; Chang, Chun-Chi Hsieh; Bianucci, Raffaella; Nerlich, Andreas G; Trautmann, Martin; Ismail, Somaia; Shanab, Gamila M L; Karim, Amr M; Gad, Yehia Z; Pusch, Carsten M

    2013-08-01

    We applied, for the first time, next-generation sequencing (NGS) technology on Egyptian mummies. Seven NGS datasets obtained from five randomly selected Third Intermediate to Graeco-Roman Egyptian mummies (806 BC-124AD) and two unearthed pre-contact Bolivian lowland skeletons were generated and characterised. The datasets were contrasted to three recently published NGS datasets obtained from cold-climate regions, i.e. the Saqqaq, the Denisova hominid and the Alpine Iceman. Analysis was done using one million reads of each newly generated or published dataset. Blastn and megablast results were analysed using MEGAN software. Distinct NGS results were replicated by specific and sensitive polymerase chain reaction (PCR) protocols in ancient DNA dedicated laboratories. Here, we provide unambiguous identification of authentic DNA in Egyptian mummies. The NGS datasets showed variable contents of endogenous DNA harboured in tissues. Three of five mummies displayed a human DNA proportion comparable to the human read count of the Saqqaq permafrost-preserved specimen. Furthermore, a metagenomic signature unique to mummies was displayed. By applying a "bacterial fingerprint", discrimination among mummies and other remains from warm areas outside Egypt was possible. Due to the absence of an adequate environment monitoring, a bacterial bloom was identified when analysing different biopsies from the same mummies taken after a lapse of time of 1.5 years. Plant kingdom representation in all mummy datasets was unique and could be partially associated with their use in embalming materials. Finally, NGS data showed the presence of Plasmodium falciparum and Toxoplasma gondii DNA sequences, indicating malaria and toxoplasmosis in these mummies. We demonstrate that endogenous ancient DNA can be extracted from mummies and serve as a proper template for the NGS technique, thus, opening new pathways of investigation for future genome sequencing of ancient Egyptian individuals. PMID:23553074

  5. University Industry (U-I) Relationship: Evidence from an Egyptian University

    OpenAIRE

    Mansour S. M. Lotayif

    2015-01-01

    The current study aims at identifying the causality relationships amongst (U-I) relationship’s variables i.e. demographics, communication, trust, satisfaction, functional conflict, afflictive commitment, expectation of continuity, willingness to invest, and collaboration. The experiences of 216 Egyptian internship’s companies were utilized to achieve these objectives. Throughout multivariate analytical technique (e.g. multiple regression), significant causality relationships have been support...

  6. Western media's influence on Egyptian adolescents' smoking behavior: the mediating role of positive beliefs about smoking.

    Science.gov (United States)

    Islam, Sondos M S; Johnson, Carl Anderson

    2007-01-01

    Western media has been implicated as an adolescent smoking risk factor in numerous Western studies, but little research has investigated that influence on adolescents from developing Arab countries. One such country is Egypt, which has the highest rate of smoking in the Arab world. An estimated 34% of Egyptians are daily smokers, 4% of whom are under the age 15 years and 0.6% of whom are under the age 10. The present study investigated the association between exposure and receptivity to Western media, positive beliefs about smoking, and Egyptian adolescents' smoking behavior. A school-based cross-sectional survey of 1,930 Egyptian adolescents in 7th, 9th, and 12th grades, from randomly selected schools in Alexandria, Egypt, was conducted in May 2003. Self-reported smoking behaviors, demographics, psychosocial factors, and exposure to Western and pro-tobacco media were assessed. Controlling for demographics, psychosocial smoking risk factors, and pro-tobacco media exposure, we found that Western media exposure was positively associated with ever-smoking across genders and 30-day smoking among adolescent males only. Positive beliefs about smoking partially mediated this association among ever-smokers and completely mediated it among 30-day male smokers. The results indicate that the influence of Western media on Egyptian adolescents' smoking behavior is at least partially mediated by its influence in increasing adolescents' positive beliefs about smoking and consequently their smoking behavior. Regulation of the glamorization of smoking behavior in Western media and correction of the erroneous perception of positive beliefs about smoking among adolescents is necessary to help curb the rising smoking epidemic in Egypt. PMID:17365737

  7. 'Urban ethnicity': culture and politics among Eritrean and Egyptian migrants in Milan

    OpenAIRE

    Ambroso, G. C.

    1987-01-01

    This thesis argues that 'ethnicity' can be seen as the interplay between culture and politics in a specific social context. It compares the ethnic identity and organization of two migrant groups, Eritreans and Egyptians, in Milan and their contrasting relationship with the 'host society'. It also assesses the theoretical significance of 'cultural strategy', 'social closure' and the 'social construction of race', evaluating their significance for the concept of 'ethnici...

  8. The Representation of Women in Street Songs: A Critical Discourse Analysis of Egyptian Mahraganat

    OpenAIRE

    Mai Samir El-Falaky

    2015-01-01

    The study investigates the representation of male and female gender identities in Egyptian street songs called Mahraganat. The study discusses the issue with reference to two common songs spreading among young commoners. Since the songs are written by writers who descend from low-standard social group, the analysis exhibits both cultural and societal notions related to how males and females are portrayed in such kind of music. This study attempts to describe how males describe their social gr...

  9. The Natural History of the Egyptian Fruit Bat, Rousettus aegyptiacus, in Turkey (Mammalia: Chiroptera)

    OpenAIRE

    ALBAYRAK, ?rfan; A?AN, Nursel; YORULMAZ, Tarkan

    2008-01-01

    Aspects of the ecology, karyology, and taxonomic status of the Egyptian fruit bat, Rousettus aegyptiacus, in the Mediterranean region of Turkey were investigated based on 41 specimens obtained between 1977 and 2003. Distribution, external and cranial morphometrics, pelage coloration, baculum morphology, karyology, colony size, roosting and feeding ecology, and conservation and management issues were recorded. The fruit bat in Turkey is represented by the nominate subspecies, R. a. aegyptiacus...

  10. Biochemical Diagnosis of Peroxisomal Disorders by GC/MS: Egyptian Patients with X-linked Adrenoleukodystrophy

    OpenAIRE

    Ekram Fateen *, Amr Gouda*, Mona Ibrahim

    2013-01-01

    Background: Peroxisomes are organelles responsible mainly for metabolism of lipids and peroxides. Lack of peroxisomes or dysfunction in any of their normal functions is the cellular basis for human peroxisomal disorders (PDs). Aim of the Work: diagnosis of peroxisomal disorders among a high risk group of Egyptian patients using gas chromatography mass spectrometry. Subjects and Methods: Forty six patients suspected to have peroxisomal disorders were included in this study. Their ages r...

  11. Residual Nitrite in Some Egyptian Meat Products and the Reduction Effect of Electron Beam Irradiation

    OpenAIRE

    Dalia A. Zahran; Gehan M.A. Kassem

    2011-01-01

    Nitrite, a curing agent of meat products, is a precursor of carcinogenic N-nitrosamines during processing of meat products or under human stomach conditions, as well as having its own toxicity. To investigate the residual nitrite level in meat products marketed in Egyptian markets, 160 samples of cured cooked (luncheon and frankfurter) and cured raw (oriental sausages and pastirma) meat products (40 sample each) were analyzed for residual nitrite by a spectrophotometric method. Samples were s...

  12. Determinants of AFM1 in breast milk in a selected group of Egyptian mothers

    OpenAIRE

    Polychronaki, Nektaria; Turner, Paul C; Mykkanen, Hannu; Gong, Yunyun; Amra, Hassan; Abdel-Wahhab, Mosaad Attia; El-Nezami, Hani

    2006-01-01

    Abstract In Egypt there is a paucity of biomarker data on aflatoxin exposure. In this study we assessed the level and frequency of breast milk AFM1 as a biomarker of maternal exposure. Breast milk samples were collected from a selected group of 388 Egyptian lactating mothers of children attending the New El-Qalyub Hospital, Qalyubiyah governorate, Egypt, during May-September 2003. Following aflatoxin extraction AFM1 levels were assessed by HPLC with fluorescence detection. Approxim...

  13. Differences in Molecular Pathologic Characteristics of PancreaticAdenocarcinoma between Egyptian andMoroccan Patients

    OpenAIRE

    Hoda Gad Omer; Mehdi Karkouri; Soliman, Amr S.; Sara Robinson; Joel F. Greenson

    2010-01-01

    Introduction:Pancreatic cancer has not been well studied, especially in developingcountries. Materials and Methods:We studied the variations in genetic mutations inpancreatic adenocarcinoma between Moroccan and Egyptian populations. Themolecular pathology of 30 tumors from a large hospital in Casablanca, Morocco wereexamined and compared with the findings of 44 tumors from the Gharbiah Governatein Egypt. K-ras mutations in codons12 and 13 in addition to p53 mutations in exons5-8 were evalu...

  14. The Lexical Knowledge and Avoidance of Phrasal Verbs: The Case of Egyptian Learners of English

    OpenAIRE

    Dina Abdel Salam El-Dakhs

    2016-01-01

    Recent studies in different parts of the world have highlighted that phrasal verbs constitute a learning difficulty for English language learners despite their confirmed significance and high productivity in English. Proposed explanations include cross-linguistic differences, the complex nature of phrasal verbs, low language proficiency and psychological factors. The present study examines this difficulty among an Arabic-speaking population of Egyptian undergraduates in a foreign language con...

  15. Near Eastern Neolithic Genetic Input in a Small Oasis of the Egyptian Western Desert.

    Czech Academy of Sciences Publication Activity Database

    Kujanová, Martina; Pereira, L.; Fernandes, V.; Pereira, J. B.; ?erný, Viktor

    2009-01-01

    Ro?. 140, ?. 2 (2009), s. 336-346. ISSN 0002-9483 R&D Projects: GA ?R GA206/08/1587 Institutional research plan: CEZ:AV0Z80020508 Keywords : Egyptian Western Desert * complete mtDNA sequences * T haplogroup * Neolithic Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 2.756, year: 2009 http://www3.interscience.wiley.com/journal/122377292/abstract?CRETRY=1&SRETRY=0

  16. Visual Function of Egyptian Children with Low Vision and the Demographic Determinants

    OpenAIRE

    El Byoumi Boshra; Mousa Ahmed

    2010-01-01

    Aims: To determine whether the LV Prasad-Functional Vision Questionnaire (LVP-FVQ) could be used to assess self-reported visual function and quality of visual life in Egyptian school aged children. Materials and Methods: The LVP-FVQ was used to assess the quality of visual function in school-age children. All subjects were students at the time of assessment. Subjects underwent a visual function assessment that included distance and near visual acuity, contrast sensitivity, color vision and vi...

  17. General performance and utilization plan of the Egyptian Second Research Reactor

    International Nuclear Information System (INIS)

    The Egyptian Second Research Reactor, ETRR-2, is a Multi-Purpose Reactor for material tests, radioisotopes production, neutron physics research, etc.. The reactor is an open pool type of 22 MWth light water cooled and moderated, with an average flux of 2x1014 n/cm2·s. Various experimental facilities are installed in the reactor to meet the requirements of the utilization group. Description of the reactor Performance and proposed utilization plan is presented. (author)

  18. The cost–benefit of biosecurity measures on infectious diseases in the Egyptian household poultry

    OpenAIRE

    Fasina, Folorunso Oludayo; Ali, A. M.; Yilma, J.M.; Thieme, O.; Ankers, P.

    2012-01-01

    Increased animal intensification presents with increasing risks of animal diseases. The Egyptian household poultry is peculiar in its management style and housing and this present with particular challenges of risk of infection to both the flock and humans. Biosecurity remains one of the most important means of reducing risks of infection in the household poultry, however not much information is available to support its feasibility at the household level of production. In this ...

  19. Improvement in detecting the carcinogenicity of bracken fern using an Egyptian toad.

    Science.gov (United States)

    El-Mofty, M M; Sadek, I A; Bayoumi, S

    1980-01-01

    Neoplasms developed in 18 of 98 toads, Bufo regularis, subjected to enforced feeding with bracken fern. They comprise 7 cases of adenocarcinoma in the ileum, 16 cases of hepatomas in the liver and 6 cases of neoplasms in the kidney due to metastases from the hepatomas. The results demonstrate that the Egyptian toad can be considered as an advantageous model for detecting the carcinogenicity of bracken fern, since the lesions occur faster than in other experimental animals. PMID:7432754

  20. Aromatase excess syndrome presenting with prepubertal gynecomastia in an Egyptian child with type 1 neurofibromatosis

    Directory of Open Access Journals (Sweden)

    Kotb Abbass Metwalley

    2013-01-01

    Full Text Available A romatase excess syndrome (AEXS is a rare autosomal dominant disorder characterized by prepubertal gynecomastia, it responds well to medical treatment. In the absence of prompt suspicion, it can expose the patient to the risk of unnecessary surgical intervention. Up to our best knowledge, the association between AEXS and neurofibromatosis type 1 (NF1 was not reported before. Here, we describe a AEXS presenting with prepubertal gynecomastia in an Egyptian child with NF1 that improved with aromatase inhibitors.

  1. Pharmacokinetics of Vancomycin in Oncology Egyptian Paediatrics: A Dosage Adjustment Trial

    OpenAIRE

    Mahmoud, M. A.; Ebid, A. H. I. M.; Shouman, Samia A.; Ebid, Emad N.

    2014-01-01

    The purpose of this study is to determine the pharmacokinetic parameters of vancomycin in Egyptian paediatric oncology patients and to evaluate the factors that influence the variability of the pharmacokinetic parameters in this population. Vancomycin serum concentration at steady state was determined in 51 paediatric cancer patients who were treated with vancomycin multiple intravenous infusions. Also individual vancomycin pharmacokinetic parameters were calculated assuming one compartment m...

  2. Characterization of Mycobacterium tuberculosis Complex DNAs from Egyptian Mummies by Spoligotyping

    OpenAIRE

    Zink, Albert R.; Sola, Christophe; Reischl, Udo; Grabner, Waltraud; Rastogi, Nalin; Wolf, Hans; Andreas G Nerlich

    2003-01-01

    Bone and soft tissue samples from 85 ancient Egyptian mummies were analyzed for the presence of ancient Mycobacterium tuberculosis complex DNA (aDNA) and further characterized by spoligotyping. The specimens were obtained from individuals from different tomb complexes in Thebes West, Upper Egypt, which were used for upper social class burials between the Middle Kingdom (since ca. 2050 BC) and the Late Period (until ca. 500 BC). A total of 25 samples provided a specific positive signal for the...

  3. EGYPTIAN LICENSE PLATE RECOGNITION USING ENHANCED STROKE WIDTH TRANSFORMATION AND FUZZY ARTMAP

    OpenAIRE

    Alaa Mohamed Youssef; Mohamed S. El-Mahallawy; Amr Badr

    2014-01-01

    License Plate Recognition (LPR) is the most important type of Intelligent Transportation System (ITS). LPR is used in many different types of ITS like electronic payment systems, toll station, parking fees, freeway and arterial management systems for traffic surveillance. Few years ago, Egyptians government changed the car license plate to include letters and numbers. So the needs for efficient LPR System for the new license plate are increased in different ITS fields. This study presents an ...

  4. Analysis of ancient Egyptian finds of metal artefacts by alpha-induced x-ray emission

    International Nuclear Information System (INIS)

    The application of the particle-induced X-ray fluorescence method for the determination of the quantitative composition of objects is described. This is a non-destructive method of analysis, is accurate and highly sensitive. The method is particularly attractive for the examination of valuable archeological finds. The results of the analyses of various Egyptian metal artefacts carried out with the method are presented and discussed

  5. The Role of Corporate Social Responsibility (CSR) in the Egyptian Banking Sector

    OpenAIRE

    Kamal, Mona

    2013-01-01

    Given the global recognition of Corporate Social Responsibility (CSR) of the financial institutions in developed countries and the lack of interest in the relevance of this concept in Egypt, it is essential to investigate the relation between Corporate Social Responsibility and Financial Performance (i.e. CSR-FP link) in the Egyptian banking sector. This paper explores, empirically, this association. The results imply a negative and statistically significant relationship between CSR-dimension...

  6. Characterization of Ancient Egyptian Wall Paintings, the Excavations of Cairo University at Saqqara

    OpenAIRE

    Hussein MAREY MAHMOUD; Nikolaos KANTIRANIS; Ali, Mona; John STRATIS

    2011-01-01

    The present study aims at characterizing some Egyptian wall paintings discovered during the excavations of Cairo University (since 1988 and recently in 2005) at Saqqara area in the south of Cairo. There, a number of tombs dating back to the 19th dynasty (c.1293–1185 BC) were discovered. The walls of these tombs are carved with bass and raised reliefs and painted with different colours. The characterization of the wall paintings was done by means of optical microscopy (OM), scanning electron ...

  7. The Effects of Job Crafting on Organizational Citizenship Behavior: Evidence from Egyptian Medical Centers

    OpenAIRE

    Amir Shusha

    2014-01-01

    This article examines the impact of job crafting on organizational citizenship behavior. On the basis of the literature of job crafting and organizational citizenship behavior, the study hypothesized that employees with a job crafting would be most likely to exercise organizational citizenship behavior. Data were collected among 396 nurses and their physician supervisors, who work in nine Egyptian Medical Centers. The results of multiple regression analyses offered a strong support for the pr...

  8. General performance and utilization plan of the Egyptian second research reactor

    International Nuclear Information System (INIS)

    The Egyptian Second Research Reactor, ETRR-2, is a multi purpose reactor for material tests, radioisotopes production, neutron physics research, etc.. The reactor is an open pool type of 22 MWth light water cooled and moderated, with an average flux of 2 X 1014 n/cm2.s. Various experimental facilities are installed in the reactor to meet the requirements of the utilization group. Description of the reactor performance and proposed utilization plan is presented. (author)

  9. Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomasis among Egyptian patients

    Directory of Open Access Journals (Sweden)

    Maghraby A.S*#, *Samia, A. Ahmed, **Ayman, M. Metwaly, and **Khalid, H

    2008-03-01

    Full Text Available Introduction: Schistosomiasis is considered as a widespread problem that affects Egyptians at different ages (WHO, 1993. It is well known that the high incidence of bladder carcinoma in schistosomal patients also represents a great risk to Egyptian society. Objective: This study represents a survey on the changes which took place in Alpha-Fetoprotein (AFP levels as a differential marker among Egyptian patients suffering from urinary bilharzial infection and bladder cancer. Methodology: A partial study was carried out on four patients post operative and followed up for sixty three days after chemotherapeutic treatment using immunoenzymatic mediated assay. Results: It was found that bladder cancer leads to obvious significant increase in AFP levels, while schistosomal infection causes a non significant decrease as compared to healthy control. Although the combination between schistosomal infection and cancer leads to a significant decrease in AFP level compared to non bilharzial cancer cases, there was no significant correlation with healthy cases. Conclusion: It should be pointed out that the somewhat constant level of AFP in the sera of all patients was due to chemotherapeutic treatment. Also, it can be noticed that there is a significant positive correlation with progress of cancer grades

  10. Epstein-Barr virus and breast cancer: Epidemiological and Molecular study on Egyptian and Iraqi women

    International Nuclear Information System (INIS)

    Background and purpose: The role of Epstein-Barr virus (EBV) in breast carcinogenesis is still controversial. Unraveling this relationship is potentially important for better understanding of breast cancer etiology, early detection and possibly prevention of breast cancer. The aim of the current study is to unravel the association between EBV and primary invasive breast cancer (PIBC) in two different Arab populations (Egyptian and Iraqi women). Patients and Methods: The study was done on paraffin-embedded tissues of 40 Egyptian and 50 Iraqi patients with PIBC in addition to 20 normal breast tissues as controls for each group. Both controls and neoplastic tissues were assessed for the expression of EBV genes and proteins (EBNA-1, LMP-1, and EBER) as well as CD21 marker by immunohistochemistry (IHC), in situ hybridization (ISH) and PCR techniques. Results: Our gold standard for EBV reactivity in breast cancer cases was positivity of both EBNA1 by PCR and EBER by in situ hybridization. EBV was detected in 18/40 (45%) and 14/50 (28%) of Egyptian and Iraqi women; respectively where p = 0.073, compared to 0/20 (0%) of their control groups (p < 0.05). Regarding the association between EBV positivity and tumor grade, there was not any statistical significant difference between EBV presence and tumor grade in both populations

  11. [Ebers Papyrus. The book of medical knowledge of the 16th century B.C. Egyptians].

    Science.gov (United States)

    Hallmann-Miko?ajczak, Aleksandra

    2004-01-01

    In 2nd century B.C. Clemens Alexanrinus was sure, that the Egyptians collected all their knowledge in 42 secret books. of which last six contained medical knowledge. Despite this and records of other ancient authors, for long time the opinion about the history of medicine was not changed. In traditional view the role of Hippocrates and the Greeks was emphasized. In 19th century egyptologist began finding Egyptian papyri, whose contents concerned medical matters. The first medical papyrus was published by Georg Ebers in 1875. The Ebers Papyrus is a scroll 20,23 meters in length and contains 108 columns of text. I is dated at the reign of Amenophis I (1536 B.C.). This papyrus was published and translated by different researches (the most valuable is German edition Grundriss de Medizin de alten ägypter, and based on this Paul Ghalioungui edition). In the opinion of Grundriss, chaotic arrangement of medical advices in papyrus suggest different originals from which they drew. The text of The Ebers Papyrus is ordered in series of prescriptions, which are grouped according to different diseases, illnesses and injuries. ALmost all of those groups have introduction by the formula: "Here begins.." used on 36 occasions. They are, however, often varied and disorganised. The owner of this papyrus was probably a physician - the text mentions about "physician secrets". Herodotus writes, that Egyptian physicians were specialized, which seems to be confirmed by The Ebers Papyrus. PMID:15586450

  12. Prune belly syndrome in an Egyptian infant with Down syndrome: A case report

    Directory of Open Access Journals (Sweden)

    Metwalley Kotb A

    2008-10-01

    Full Text Available Abstract Introduction Prune belly syndrome is a rare congenital anomaly of uncertain aetiology almost exclusive to males. The association between prune belly syndrome and Down syndrome is very rare. Case presentation A 4-month-old Egyptian boy was admitted to our institute for management of acute bronchiolitis. He was born at full term by normal vaginal delivery. His mother, a 42-year-Egyptian villager with six other children, had no antenatal or prenatal care. On examination, the boy was found to be hypotonic. In addition to features of Down syndrome, karyotyping confirmed the diagnosis of trisomy 21. Ultrasound examination of the abdomen showed bilateral gross hydronephrosis with megaureter. Micturating cystourethrography showed grade V vesicoureteric reflux bilaterally with no urethral obstruction. Serum creatinine concentration was 90 ?mol/litre, serum sodium was 132 mmol/litre and serum potassium was 5.9 mmol/litre. Conclusion We report an Egyptian infant with Down syndrome and prune belly syndrome. The incidence of this association is unknown. Routine antenatal ultrasonography will help in discovering renal anomalies which can be followed postnatally. Postnatal detection of prune belly syndrome necessitates full radiological investigation to detect any renal anomalies. Early diagnosis of this syndrome and determining its optimal treatment are very important in helping to avoid its fatal course.

  13. Characterization of Ancient Egyptian Wall Paintings, the Excavations of Cairo University at Saqqara

    Directory of Open Access Journals (Sweden)

    Hussein MAREY MAHMOUD

    2011-09-01

    Full Text Available The present study aims at characterizing some Egyptian wall paintings discovered during the excavations of Cairo University (since 1988 and recently in 2005 at Saqqara area in the south of Cairo. There, a number of tombs dating back to the 19th dynasty (c.1293–1185 BC were discovered. The walls of these tombs are carved with bass and raised reliefs and painted with different colours. The characterization of the wall paintings was done by means of optical microscopy (OM, scanning electron microscopy (backscattered electron mode, BSE equipped with an energy dispersive X-ray detector (EDS, micro XRF spectrometry (µ-XRF, and X-ray diffraction analysis (XRD. The analysis of the examined samples indicated that the blue pigment is Egyptian blue (Cuprorivaite, the green pigment is Egyptian green, the red pigment is red ochre, and the yellow pigment is a blended layer of yellow ochre and orpiment (As2S3. The results will help in providing an image concerning some painting materials used during the new Kingdom in ancient Egypt

  14. Application of DNA (RAPD and ultrastructure to detect the effect of cadmium stress in Egyptian clover and Sudan grass plantlets

    Directory of Open Access Journals (Sweden)

    Amina A. Aly

    2012-04-01

    Full Text Available BackgroundIn recent years, several plant species have been used as bioindicators to evaluate the toxicity of environmental contaminants on vegetal organisms. In this study, Egyptian clover and Sudan grass seedlings were grown in four cadmium (Cd concentration levels (0.0, 25, 50 and 100 µM in MS media to analyze growth responses, Cd accumulation in the shoots and roots of plantlets, proline contents, chlorophylls content and MDA levels of both plantlets. As well as RAPD analysis and leaves ultrastructure were detected.ResultsThe results showed that there was a significant decrease in root and shoot lengths, Chl a, Chl b, total Chl and carotenoids contents for both Egyptian clover and Sudan grass. However, there was a significant increase in Cd accumulation, proline and malondialdehyde (MDA levels. The genetic variation between Egyptian clover and Sudan grass were evaluated using random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR markers to establish specific DNA markers associated with Cd stress. The results of transimssion electron microscopy (TEM showed a clear disorder in the Cd treated Egyptian clover and Sudan grass seedlings.ConclusionIn conclusion, biochemical, molecular and ultrastructure changes in Egyptian clover and Sudan grass could be used as a useful biomarker assay for the detection of genotoxic effects of Cd stress on plants. However, it is necessary to be further confirmed and optimized in the future research.

  15. An Examination of Learning Style Preferences among Egyptian University Students

    Science.gov (United States)

    Sywelem, Mohamed; Dahawy, Bayoumi; Wang, Chih-husan

    2010-01-01

    The purpose of this research was to examine teacher students' learning style preferences and to examine the extent gender, seniority and academic major affect the students' preferences. (Contains 4 tables and 1 figure.)

  16. High salt and high pH tolerance of new isolated Rhizobium etli strains from Egyptian soils.

    Science.gov (United States)

    Shamseldin, Abdelaal; Werner, Dietrich

    2005-01-01

    Saline and alkaline soils are major problems contributing to the low productivity of common bean (Phaseolus vulgaris) in arid and semi-arid regions such as Egypt. Therefore our study was directed toward selecting strains more tolerant to these environmental stresses. Among seven Rhizobium etli strains isolated from Egyptian soils, we found a high degree of diversity. Strains EBRI 21 and EBRI 26 are highly tolerant to a salt concentration up to 4% NaCl. A positive correlation was found between the salt tolerance and the adaptation to alkaline pH (9). Strains EBRI 2 and EBRI 26 were adapted to elevated temperatures (42 degrees C). The minimum level of low pH for the majority of Rhizobium etli strains from Egypt was pH 4.7 while the Colombian strain Rhizobium tropici CIAT 899 survived well at pH 4. At 0.4% NaCl, the symbiotic efficiency of the salt-tolerant strain EBRI 26 was superior in cultivar Giza 6 compared with the salt-sensitive strain EBRI 2 (18.2 compared with 13.9 nM: C2H4 h(-1) mg(-1) nodule fresh weight). In the bean cultivar Saxa, nitrogen fixation was much more affected by high salt concentration (0.4% NaCl) than in the cultivar Giza 6 with both strains (3.9 and 3.8 nM: C2H4 h(-1) mg(-1) nodule fresh weight, respectively). In general, stress of alkalinity had a less detrimental effect on nodulation and N2 fixation than stress of salinity. PMID:15702257

  17. Pelagic coelenterates in the waters of the western part of the Egyptian Mediterranean Coast during summer and winter

    OpenAIRE

    Howaida Y. Zakaria

    2004-01-01

    During August 2000 and February 2001 two cruises were carried out along the Egyptian Mediterranean Coast on the Egyptian r/v "El-Yarmouk". The samples collected were used to study the ecology and distribution of hydromedusae and siphonophores during summer and winter. The density of hydromedusae was high in the inshore waters during summer (av. 71 org × 100 m-3), decreasing to 28 organisms per 100 m3 in the oceanic waters; in winter they were more abundant in the middle and offshore zo...

  18. A COMPARISON OF DUCK AND CHICKEN EGG YOLK FOR CRYOPRESERVATION OF EGYPTIAN BUFFALO BULL SPERMATOZOA

    Directory of Open Access Journals (Sweden)

    Ibrahim El-Shamaa

    2012-01-01

    Full Text Available Cryopreservation of domestic animal spermatozoa has been widely used for artificial insemination and egg yolk is oneof the most commonly used cryoprotectants during the freezing- thawing process. The aim of the present study was tocompare the effectiveness of different duck egg yolk (DEY concentrations (10, 15 and 20% DEY with chicken egg yolk (20% CHEY on the cryopreservation of Egyptian buffalo spermatozoa following dilution, equilibration and freezingthawing processes. For this purpose, one ejaculate of semen from each of three Egyptian buffalo bulls were collectedtwice each week for 4 weeks with artificial vagina (42ºC. Pooled ejaculates were divided into four parts and werediluted in Tric citric acid glycerol extender containing either 10 or 15 or 20% DEY or 20% CHEY at 37ºC. Extendedsemen was equilibrated for 4h at 5ºC and then was filled in 0.5 ml straws and frozen in liquid nitrogen. Thawing ofsemen was performed at 37ºC for 30s. Progressive sperm motility, live sperm % and plasma membrane integrity afterdifferent stages of cryopreservation were assayed. Values of these parameters of post-thaw semen quality were higherfor extender containing 15% DEY as compared with 20% CHEY (control extender, being 59.6% vs. 47.9%, 72.3% vs.55.0% and 80.7% vs. 69.1% for progressive motility, live sperm and plasma membrane integrity, respectively. Using apost-thawing semen containing 15% DEY yielded comparatively highest conception rate (65.8% followed by 20% DEY(59.3%, 20% CHEY (58.6% and 10% DEY (58.1%. In conclusion, DEY compared to chicken egg yolk in extenderimproves the frozen-thawed quality of Egyptian buffalo bull spermatozoa and fertility rate.

  19. IN VITRO GERMINATION AND CAULOGENESIS IN EGYPTIAN HUSK TOMATO (PHYSALIS PUPESCENS L.

    Directory of Open Access Journals (Sweden)

    Mona M. Yousry

    2014-03-01

    Full Text Available -The effects of chilling treatments and darkness durations on seed germination and seedling growth of Egyptian husk tomato (Physalis pubescens L."Balady" cv. was investigated. The experiment consisted of two parts; firstly the seeds of the tested cultivar were incubated for chilling in the refrigerator at 4°C for ( 0, 1, 2, 3, 4 and 5 days; second seeds were germinated in test tubes contained ten seeds and incubated in the darkness by covering them with aluminum foil each ,for 3, 6, 9 ,12, 15, 18, 21, 24, 27 and 30 days at 25 ±1°C ; then they exposed to light (16 hrs. for further 3-5 days. The obtained results indicated significant enhancement of germination percentage at 27days of darkness and 2 days at 4°C. The present study has demonstrated the advantages of chilling the seeds in darkness before subjected to light in order to reduce the long germination period of Egyptian husk tomato. Notably, as soon as the covered seeds were exposed to light, they have been germinated immediately. A protocol was developed for caulogenesis and regeneration for the Egyptian husk tomato Balady cv. Hypocotyl and leaf explants were used as a starting material for callus induction. Maximum caulogenesis from hypocotyls and leaf explants were obtained on MS medium supplemented with BAP (1.000 to 4.000 mg/l in combinations with NAA at 0.250 mg/l. For regeneration, the callus was transferred to MS hormone-freemedium for shooting. The neoformed shoots were rooted on MS medium augmented with NAA at (0.000, 0.125, 0.250, 0.500, 1.000 and 2.000mg/l and all responded were positive.

  20. Epidemiological aspects of Budd-Chiari in Egyptian patients: A single-center study

    Directory of Open Access Journals (Sweden)

    Mohammad Sakr

    2011-01-01

    Full Text Available AIM: To describe the socio-demographic features, etiology, and risk factors for Budd-Chiari syndrome (BCS in Egyptian patients. METHODS: Ninety-four Egyptian patients with confirmed primary Budd-Chiari syndrome were presented to the Budd-Chiari Study Group (BCSG and admitted to the Tropical Medicine Department of Ain Shams University Hospital (Cairo, Egypt. Complete clinical evaluation and laboratory investigations, including a thrombophilia workup and full radiological assessment, were performed to determine underlying disease etiologies. RESULTS: BCS was chronic in 79.8% of patients, acute or subacute in 19.1%, and fulminant in 1.1%. Factor V Leiden mutation (FVLM was the most common etiological cause of disease (53.1%, followed by mutation of the gene encoding methylene tetrahydrofolate reductase (MTHFR (51.6%. Current or recent hormonal treatment was documented in 15.5% of females, and BCS associated with pregnancy was present in 17.2% of females. Etiology could not be determined in 8.5% of patients. Males had significantly higher rates of MTHFR gene mutation and Behçet’s disease, and females had significantly higher rates of secondary antiphospholipid antibody syndrome. A highly significant positive relationship was evident between the presence of Behçet’s disease and inferior vena caval occlusion, either alone or combined with occlusion of the hepatic veins (P < 0.0001. CONCLUSION: FVLM is the most common disease etiology and MTHFR the second most common in Egyptian BCS patients. BCS etiology tends to vary with geographic region.

  1. Modeling the dependency of radon concentration levels inside ancient Egyptian tombs on the ambient temperature variations

    International Nuclear Information System (INIS)

    Radon concentration inside partially closed places like dwellings, caves and tombs, depends on many parameters. Some parameters are known quantitatively as radon exhalation rate for walls, decay constant, surface to volume ratio and outdoor concentration while other parameters as ventilation rate is in common known qualitatively due to useless of traditional methods (tracer gases) in many places as ancient Egyptian tombs. This work introduces a derived mathematical model to evaluate the sensitivity of radon concentration levels inside single sided opening places as ancient Egyptian tombs on the ambient temperature differences. The obtained formula for the natural ventilation rate depends on the indoor and outdoor temperature difference and the geometrical dimensions of the doorway. The effects of in and out flow mixing, air viscosity, streamline contraction, swirling flow and turbulence, were taken into consideration in terms of an empirical correction factor. According UNSCEAR reports, the exhalation rate Φ=Craλrn fρs(1-ε)L; Cra the effective radium content, λrn decay constant, f emanation fraction, ρs soil grain density, ε porosity and L diffusion length, these are approximately static parameters but the variability of ambient temperature introduces a source of energy of fluctuating strength to radon atoms in rocks which controls the flow rate and the ambient content of radon. Therefore, the change of outdoor and indoor temperature difference causes fluctuation of value and direction of volume flow rate in such places consequently causes the daily variation and on average the seasonal variation of radon concentration. Therefore according to the present model, the daily accurate expectation of radon concentrations inside ancient Egyptian tombs, require precise measurements of indoor and outdoor temperatures

  2. Breast cancer laterality among Egyptian patients and its association with treatments and survival

    International Nuclear Information System (INIS)

    Background and aim: Breast cancers (BCs) involve the left side (LS) more than the right side (RS). Among the Egyptians, neither BC laterality nor its association with demographic factors, tumor locations, treatments and outcomes were previously reported. Patients and methods: Laterality was analyzed among 5459 BCs from the Gharbiah population- based cancer registry covering > 5% of the Egyptian population. Cox proportional model was used to assess the independent effect of stage, ER, and laterality on overall survival (OS). Results: In Egypt, BCs involve LS more than RS with LS-to-RS ratio (LRR) of 1.16. LS predominance was evident among men and women and both younger (< 45 years) and older patients. HER2 over-expression and ductal cancers were significantly more in RSBCs while lobular cancers were significantly more in LSBCs. There were no significant differences in localization within the breast between LSBCs and RSBCs (p = 0.51). LS predominance was noticed across all subgroups except in patients with HER2 positive tumors (LRR = 0.63; p = 0.02). OS was significantly better in stage II and ER positive tumors than stage III and ER negative tumors. Despite OS of LSBCs being generally lower than RSBCs, this was not statistically significant. The significant impact of stage on OS was lost in LSBCs. ConclTusions: Among Egyptian patients, the left breast is at greater risk of cancer than the right one. Despite right-sided tumors seemed more aggressive, Left-sided ones tend to confer worse survival than right-sided tumors.

  3. Enhancement of the folate content in Egyptian pita bread

    OpenAIRE

    Cornelia M. Witthöft; Mohammed Hefni

    2012-01-01

    Introduction: Egypt has a high incidence of neural tube defects related to folate deficiency. One major food source for folate is pita (baladi) bread, which is consumed daily. Bioprocessing (e.g. germination) has been reported to increase the folate content in cereals. The aim was to produce pita bread with increased folate content using germinated wheat flour (GWF).Methods: Prior to milling the effects of germination and drying conditions on folate content in wheat grains were studied. Pita ...

  4. Perspectives of Egyptian Research Ethics Committees Regarding Their Effective Functioning

    OpenAIRE

    Matar, Amal; Silverman, Henry

    2013-01-01

    The recent increase in research in the Middle East has been associated with the establishment of research ethics committees (RECs). Our aim was to obtain perspectives of RECs regarding the challenges that impede their effective functioning. We conducted in-depth interviews using a semi-structured interview guide. We transcribed and analyzed the interviews to uncover major themes and subthemes. We identified the following themes: membership composition; training needs of members; availability ...

  5. Lead isotope systematics of some igneous rocks from the Egyptian Shield

    Science.gov (United States)

    Gillespie, J. G.; Dixon, T. H.

    1983-01-01

    Lead isotope data on whole-rock samples and two feldspar separates for a variety of Pan-African (late Precambrian) igneous rocks for the Egyptian Shield are presented. It is pointed out that the eastern desert of Egypt is a Late Precambrian shield characterized by the widespread occurrence of granitic plutons. The lead isotope ratios may be used to delineate boundaries between Late Precambrian oceanic and continental environments in northeastern Africa. The samples belong to three groups. These groups are related to a younger plutonic sequence of granites and adamellites, a plutonic group consisting of older tonalites to granodiorites, and the Dokhan volcanic suite.

  6. Size, Value and Turn-of-the-Year Effect in the Egyptian Stock Market

    OpenAIRE

    Mohamed A. Shaker; Khairy Elgiziry

    2014-01-01

    This paper is an attempt to investigate the relation of financial anomalies, namely size, book-to-market and turn-of-the-year and their relation with risk and average return in the Egyptian stock market from 2003 to 2007. The sample consists of 55 stocks listed on the EGX100 and split into six portfolios sorted on size and book-to-market ratio based on Fama-French (1992) technique. The results show evidence that there is negative relationship between size and average return, and between value...

  7. Exfoliation of Egyptian Blue and Han Blue, Two Alkali Earth Copper Silicate-based Pigments

    OpenAIRE

    Johnson-McDaniel, Darrah; Salguero, Tina T.

    2014-01-01

    In a visualized example of the ancient past connecting with modern times, we describe the preparation and exfoliation of CaCuSi4O10 and BaCuSi4O10, the colored components of the historic Egyptian blue and Han blue pigments. The bulk forms of these materials are synthesized by both melt flux and solid-state routes, which provide some control over the crystallite size of the product. The melt flux process is time intensive, but it produces relatively large crystals at lower reaction temperature...

  8. Transcultural use of narcotic water lilies in ancient Egyptian and Maya drug ritual.

    Science.gov (United States)

    Emboden, W A

    1981-01-01

    Comparisons are made between ancient ritual uses of the flowers of Nymphaea (Nymphaeaceae) in Maya and Egyptian civilizations. Recurrent motifs encountered in the art of both of these ancient civilizations suggests that the role fo the water lily was that of a narcotic (psychodysleptic) used to mediate ecstasis among a priestly caste. Relevant literature is reviewed as are chemical data. Elements in the complex belief systems of these two civilizations need to be reinterpreted in view of the use of two water lilies as ritual narcotics. The species implicated are Nymphaea caerulea Sav., in Egypt, and N. ampla DC., among the Maya. PMID:7007741

  9. Aliens in Egyptian Mediterranean waters. A check-list of Erythrean fish with new records

    Directory of Open Access Journals (Sweden)

    Y. HALIM

    2012-12-01

    Full Text Available The historical role of the Suez Canal as a pathway for migrations between the Red sea and the Mediterranean is recalled. A check-list of 42 immigrant Erythrean fish in Egyptian Mediterranean waters is given. The list comprises four new records. 17 of the immigrant species are commercially exploited, whereas 15 are known from single records. While the Erythrean fish as invasive species are beneficial to local fisheries, in our view, they do not have an important impact upon the ecosystem.

  10. 210Polonium source-sink concentrations in some Egyptian brands of cigarettes

    International Nuclear Information System (INIS)

    Samples of fine and popular brand cigarettes were collected from those available on the Egyptian market. 210Po concentrations were measured by alpha spectrometry using surface barrier detectors, following sample dissolution and the plating out of 210Po on stainless steel disks from diluted HCl solution. 208Po was used for chemical recovery calculations. The material balance (i.e. source-sink) for 210Po was determined. The ratio of 210Po recovery to the total amount was assessed. The health hazard arising due to 210Po is briefly discussed here. (orig.)

  11. Yellow, red and blue pigments from ancient Egyptian palace painted walls

    Energy Technology Data Exchange (ETDEWEB)

    Uda, M. E-mail: muda@mn.waseda.ac.jp; Sassa, S.; Yoshimura, S.; Kondo, J.; Nakamura, M.; Ban, Y.; Adachi, H

    2000-03-01

    Yellow, red and blue pigments from the painted walls of the Malqata palace, founded by Amenhotep III, 18th Dynasty, were analyzed using PIXE and X-ray diffraction (XRD). From most of the yellow, red and blue parts, goethite, hematite and Egyptian blue, respectively, were found on the basis of diffractometry results. From some yellow parts, As was detected together with Fe spectroscopically, suggesting the use of orpiment as a yellow pigment. The red pigment seems to be natural and not man-made. This assumption is deduced from the dehydration experiment of a synthesized goethite.

  12. Potassium body burdens in occupational users of egyptian nuclear research center

    International Nuclear Information System (INIS)

    A simple calibration procedure for inshas whole body counter for evaluating total potassium have been adopted. More than 120 egyptian employee in the nuclear research center (N. R. C.) were studied for their total body potassium (TBK). The potassium values were found to have an average of 2.85 gm k kg-1 body weight for males and 2.62 gm k kg-1 for females, which is higher than the recommended value given for reference man by ICRP. The TBK varied directly with body build index and is slightly dependent.7 figs., 1 tab

  13. The bidirectional relation between psychiatric disorders with selected cardiovascular and endocrinal diseases: an Egyptian perspective.

    Science.gov (United States)

    Okasha, Tarek; Radwan, Ash-Shayma

    2015-01-01

    Cardiovascular and endocrine diseases may act as burdens for individuals suffering from one of these medical illnesses, and whether through the ensuing psychological distress, or some biological mechanisms, these medical diseases can eventually lead to the development of psychiatric morbidities. Moreover, psychiatric morbidities negatively affect the prognosis of both cardiovascular and endocrine diseases. Despite transcultural differences, Egyptian patients with ischemic heart diseases (ISHD), heart failure (HF), diabetes mellitus (DM), or thyroid diseases (TD) endure the same psychological distress as their Western counterparts. Psychiatric assessment and evaluation should be regularly repeated among patients with cardiovascular and endocrinal diseases, and patients who are at risk should be closely followed up. PMID:25413635

  14. Hepatitis C and B Viruses Among Some High Risk Groups of Egyptian Children

    OpenAIRE

    Manal E. Kandil; Maha A. Rasheed; Nevine E. Saad

    2007-01-01

    The aim of this study was to detect seroprevalence of hepatitis C virus antibodies (anti-HCV), hepatitis B surface antigen (HBsAg) and antibody (anti-HBs) among some high risk groups of Egyptian children and its effect on liver functions. We clinically examined 100 children who were classified into 4 groups; group 1:34 children with Insulin Dependent Diabetes Mellitus (IDDM), group 2:31 children having Chronic Renal Failure (CRF) on regular hemodialysis, group 3:15 patients with Systemic Lupu...

  15. Aflatoxin production by Aspergillus Flavus on irradiated and non-irradiated stored egyptian bread

    International Nuclear Information System (INIS)

    Aflatoxins production by Aspergillus Flavus isolate on several types of egyptian bread samples through a period of 45 days at different temperatures reveled that there was detectable fungal growth but no aflatoxins were produced at 5±1 degree or 37 degree. At 25 degree or 30 degree aflatoxin were produced after 5-6 days on the different bread types. Gamma irradiation of kaiser bread, previously inoculated with Aspergillus Flavus, reduced the amount of aflatoxins produced on subsequent storage for 8 weeks at 26±1 degree. The 5 KGy dose eliminated fungal growth and aflatoxin production. 4 tab

  16. EFFECT OF LOW DENSITY LIPOPROTEINS IN EXTENDER ON FREEZABILITY AND FERTILITY OF EGYPTIAN BUFFALO BULL SEMEN

    OpenAIRE

    El-Seify; I. M.; Abd El-Razek; M.A.R.; Ibrahim ,; I S; El-Shamaa; M. E.; El-Sharawy; E.M.

    2012-01-01

    Semen from three Egyptian buffalo bulls was collected once weekly and ejaculates with more 75% progressive motility and more 85 % normal sperm morphology prior to cryopreservation were pooled in order to have sufficient semen for a replicate and to eliminate the bulls effect. Seven extenders were used: Tris 20 % egg yolk extender with 7 ml glycerol as a control (T1), and substitution of whole egg yolk with 4, 6, 8, 10, 12 and 15 % low density lipoprotein (LDL), T2 – T6, respectively. Semen wa...

  17. The Person in an Egyptian judicial Context : An Ethnomethodological Analysis of Courtroom Proceedings

    OpenAIRE

    Dupret, Baudouin

    2003-01-01

    In Egyptian law, the notion of the person is formulated in statute law, used in case-law, and practiced in what is called "law in action". It is closely associated with the concept of legal capacity and incapacity. This article concentrates on legal practices related to the person as they emerge from actual legal interactions in judicial contexts. This will lead to propose a praxiological approach to the norm, the law, and the following of a rule. Such praxiological sociology allows to observ...

  18. Studies on the s_dm.t=f verb form in Classical Egyptian

    OpenAIRE

    Zonhoven, Ludovicus Martinus Johannes,

    1997-01-01

    This study is devoted to some synchronic aspects of the sDm.t=f verb form, primarily its meaning and uses in Classical Egyptian. In the introduction some attention is paid to the history of the studies of the form and its origin, an aspect which will receive no further consideration. In accordance with present common opinion the sDm.t=f is here considered to belong to the suffix conjugation. Ch. I is primarily concerned with the active Dr sDm.t=f construction, but begins with a...

  19. Association between Macronutrients Intake, Visceral Obesity and Blood Pressure in a Sample of Obese Egyptian Women

    OpenAIRE

    Nayera E. Hassan; Salwa M. El Shebini; Nihad H. Ahmed; Mohamed Selim Mostafa

    2015-01-01

    AIM: Study the association between the total caloric intake, protein, lipid, and some classes of fatty acids of the diet, and their effects on blood pressure in a sample of Egyptian obese women with and without visceral obesity. METHODS: Five hundred forty-nine obese women were included in the study with mean age of 38.1 ± 11.56 years and mean Body mass index [BMI] of 36.17 ± 7.23. They enrolled in a program for losing weight. Visceral fat was determined using ultrasound. Blood pressure wa...

  20. Applying Co-Evolutionary Particle Swam Optimization to the Egyptian Board Game Seega

    OpenAIRE

    Abdelbar, Ashraf M.; Ragab, Sherif; Mitri, Sara

    2003-01-01

    Seega is an ancient Egyptian two-phase board game that, in certain aspects, is more dif?cult than chess. The two-player game is played on either a 5 × 5, 7 × 7, or 9 × 9 board. In the ?rst and more dif?cult phase of the game, players take turns placing one disk each on the board until the board contains only one empty cell. In the second phase players take turns moving disks of their color; a disk that becomes surrounded by disks of the opposite color is captured and removed from the board. W...

  1. Experimental Inoculation of Egyptian Fruit Bats (Rousettus aegyptiacus) with Ebola Virus

    OpenAIRE

    Janusz T. Paweska; Nadia Storm; Antoinette A. Grobbelaar; Wanda Markotter; Alan Kemp; Petrus Jansen van Vuren

    2016-01-01

    Colonized Egyptian fruit bats (Rousettus aegyptiacus), originating in South Africa, were inoculated subcutaneously with Ebola virus (EBOV). No overt signs of morbidity, mortality, or gross lesions were noted. Bats seroconverted by Day 10–16 post inoculation (p.i.), with the highest mean anti-EBOV IgG level on Day 28 p.i. EBOV RNA was detected in blood from one bat. In 16 other tissues tested, viral RNA distribution was limited and at very low levels. No seroconversion could be demonstrated in...

  2. Vitamin A and its inhibitory effect as tested on Egyptian toads.

    Science.gov (United States)

    Sadek, I A

    1981-01-01

    Neoplasms of the liver were induced in 18 cases out of 44 in the Egyptian toad, Bufo regularis, by injection with 20-methylcholanthrene. Dose level was 10 mg/50 g body weight once a week. However, the injection of the same dose level of this hydrocarbon together with vitamin A palmitate on the level of 20,000 IU/50 g body weight once a week was found to develop hepatomas in the liver in only 1 of 45 cases. Results of this study indicate that vitamin A palmitate inhibited the carcinogenic effect of 20-methylcholanthrene. PMID:7443172

  3. The induction of neoplastic lesions by aflatoxin-B1 in the Egyptian toad (Bufo regularis).

    Science.gov (United States)

    el-Mofty, M M; Sakr, S A

    1988-01-01

    The carcinogenic activity of aflatoxin-B1, the metabolic product of the mold Aspergillus flavus (a commonly occurring contaminant of groundnuts and other foodstuffs), was tested using the Egyptian toad (Bufo regularis). Injecting the toads with aflatoxin-B1 at a dose level of 0.01 mg/50 g body wt in 1 ml corn oil once a week for 15 weeks induced hepatocellular carcinomas in 19% of the experimental toads. Four toads developed tumors in the kidney due to metastases from the primary hepatocellular carcinomas. PMID:3127814

  4. Short-term studies of the effect of acrylamide on the testes of the Egyptian toad.

    Science.gov (United States)

    Sadek, I A

    1989-01-01

    The treatment of male Egyptian toads (Bufo regularis) with acrylamide (1 mg/toad twice a week for four weeks) was followed by atrophy of the testes, inhibition of spermatogenesis and necrosis of the seminiferous tubules with signs of vacuolation. Ultrastructurally, the Leydig cells of treated toads displayed varying degrees of vacuolation of the mitochondria, with a decrease in the number of ribosomes. The mechanism of the action of acrylamide in inhibiting spermatogenesis may be due to a decrease in the testosterone level, as borne out by vacuolation of the mitochondria and the decrease in the ribosomes in the Leydig cells of treated animals. PMID:2634605

  5. Induction of neoplasms in Egyptian toads Bufo regularis by oil of chenopodium.

    Science.gov (United States)

    el-Mofty, M M; Khudoley, V V; Sakr, S A; Ganem, N F

    1992-01-01

    Feeding the Egyptian toad Bufo regularis with oil of the chenopodium plant induced hepatocellular carcinomas in 23% of the animals, and metastases of the primary liver tumors appeared in the kidneys of 6 toads. The earliest evidence of tumors appeared after 3 months of treatment. The average latent period of tumor induction was 3.6 +/- 0.4 months. It is speculated that oil of chenopodium may be one of the constituents of Chenopodium ambrosoides which is responsible for tumor induction in the toads B. regularis. PMID:1495755

  6. Changes in composition of colostrum of Egyptian buffaloes and Holstein cows

    OpenAIRE

    Abd El -Fattah Alaa M; Abd Rabo Fawzia HR; EL-Dieb Samia M; El-Kashef Hany A

    2012-01-01

    Abstract Background Changes in colostrum composition of Egyptian buffaloes and Holstein cows collected at calving, 6, 12, 24, 48, 72, 96, 120 h and after 14 days of parturition were studied. Total solids, total protein, whey proteins, fat, lactose and ash contents were determined. Macro- and micro-elements, IgG, IgM, IGF-1, lactoferrin and vitamins (A and E) were also estimated. Results At calving, the total protein and whey proteins concentration did not differ between buffalo and cow colost...

  7. Terahertz, X-ray and neutron computed tomography of an Eighteenth Dynasty Egyptian sealed pottery

    Science.gov (United States)

    Abraham, E.; Bessou, M.; Ziéglé, A.; Hervé, M.-C.; Szentmiklósi, L.; Kasztovszky, Z. S.; Kis, Z.; Menu, M.

    2014-09-01

    An Eighteenth Dynasty Egyptian sealed pottery stored at the Museum of Aquitaine (Bordeaux, France) has been investigated using terahertz radiation, X-rays and neutrons. THz computed tomography revealed nondestructively the presence of content, whereas X-rays and neutrons analyzed more precisely the fabrication process and conservation of the pottery together with the nature of this content owing to higher spatial resolution and contrast. With neutron tomography, we determined the method used to seal the jar as well as the finer structure of the inner content. Neutron-induced prompt gamma spectroscopy was finally applied to measure the elemental composition of the content, which is supposed to consist of dried germinated seeds.

  8. Does Egyptian orange exports really have a market power in Saudi Arabia market?

    OpenAIRE

    Yasser S. A. Mazrou

    2015-01-01

    Egypt is one of the important orange exporters and Saudi Arabia also is an important import orange market. The Saudi orange market is a main market for Egypt which has a market share that exceeds half of Saudi orange market by 55.72%. This article aims to discover the degree of market power for Egyptian orange exports and other competitors in the Saudi market and if it is considered a measure of the relative mark- up by applying Residual Demand Elasticity approach. The results show that Egypt...

  9. Determinants of Egyptian Agricultural Exports: A Gravity Model Approach

    OpenAIRE

    Xuexi Huo; Assem Abu Hatab; Eirik Romstad

    2010-01-01

    In this paper, a gravity model approach was employed to analyze the main factors influencing Egypt’s agricultural exports to its major trading partners for the period 1994 to 2008. Our findings are that a one percent increase in Egypt’s GDP results in roughly a 5.42 percent increase in Egypt’s agricultural export flows. In contrast, the increase in Egypt’s GDP per capita causes exports to decrease, which is attributed to the fact that an increase in economic growth, besides the increasing pop...

  10. Non-destructive and in situ analysis of Egyptian wall paintings by X-ray diffraction and X-ray fluorescence portable systems

    International Nuclear Information System (INIS)

    The concurrence and complementarities of obtained images under various wavelengths and the elemental and structural analyses provided by XRF and XRD, using portable non-invasive systems, have allowed for obtaining accurate data about the employed pictorial technique in two Egyptian wall paintings dating from the New Kingdom. Thus, compounds such as Egyptian blue, Egyptian green, goethite, jarosite, hematite, calcite, anhydrite or huntite have been detected in the paintings. The performance of the measurements by the different techniques and its contribution to the knowledge of the materials are discussed. They notably give a clue on the origin of arsenic compounds, unexpectedly detected in some decors. (orig.)

  11. Non-destructive and in situ analysis of Egyptian wall paintings by X-ray diffraction and X-ray fluorescence portable systems

    Energy Technology Data Exchange (ETDEWEB)

    Pages-Camagna, S.; Laval, E.; Vigears, D.; Duran, A. [Palais du Louvre, Centre de Recherche et de Restauration des Musees de France, C2RMF CNRS UMR 171, Paris (France)

    2010-09-15

    The concurrence and complementarities of obtained images under various wavelengths and the elemental and structural analyses provided by XRF and XRD, using portable non-invasive systems, have allowed for obtaining accurate data about the employed pictorial technique in two Egyptian wall paintings dating from the New Kingdom. Thus, compounds such as Egyptian blue, Egyptian green, goethite, jarosite, hematite, calcite, anhydrite or huntite have been detected in the paintings. The performance of the measurements by the different techniques and its contribution to the knowledge of the materials are discussed. They notably give a clue on the origin of arsenic compounds, unexpectedly detected in some decors. (orig.)

  12. Radiation dose estimation of sand samples collected from different Egyptian beaches

    International Nuclear Information System (INIS)

    A high pure germanium detector-based gamma-ray spectroscopy low-background counting system was used to determine the levels of natural radioactivity from beach sand samples on the Egyptian coast along the Mediterranean and Red Seas. The activity concentrations of 226Ra, 232Th and 40K were found to lie in the range of 30±11 to 60±14 Bq kg-1 with a mean of 39±15 Bq kg-1, 12±3 to 30±14 Bq kg-1 with a mean of 21±13 Bq kg-1 and 392±22 to 413±22 Bq kg-1 with a mean of 402±23 Bq kg-1, respectively. Radiation hazard indices and annual effective doses were evaluated and compared with the international data. The results indicate that the values obtained fall below the internationally accepted maximum limits and do not pose any significant radiation hazard to individuals in the study area. From these results, a radiological baseline map of Egyptian beaches can be drawn and used as reference information to assess any future alterations in the radioactivity of beach sands due to any changes in the sea sediments. (authors)

  13. Schoolteachers' awareness about scholastic performance and nutritional status of Egyptian schoolchildren.

    Science.gov (United States)

    Galal, Osman M; Ismail, Ibrahim; Gohar, Azza S; Foster, Zoë

    2005-06-01

    Malnutrition disorders affect more than 30% of schoolchildren in Egypt. This problem appears to be largely attributable to poor dietary quality and micronutrient deficiencies, such as iron and vitamin A. Inadequate nutrition intake has important implications because malnutrition has been shown to negatively affect the cognitive development of primary schoolchildren. This study assesses the awareness of schoolteachers about the impact of malnutrition on the scholastic performance of primary schoolchildren living in Egypt. Two focus group discussions were conducted with Egyptian schoolteachers from the Quena and Kharbia Governorates. The study indicates that schoolteachers consider low body weight and thinness as the primary signs of malnutrition. They do not prioritize malnutrition as a factor for poor scholastic performance. They also suggest that unhealthful eating habits, especially a lack of breakfast, negatively affect children's interaction with schoolteachers and their ability to excel in their studies. Schoolteachers endorse a more reliable and nutritionally valuable school-feeding program as a way to increase the scholastic performance of their students. The teachers advocate developing integrated programs between the Ministry of Education, the Ministry of Health and Population, teachers, children, and parents that provide nutrition education. A lack of awareness among teachers about the relationship of nutrition and cognitive function can lead to the misdiagnosis or delayed management of malnourished and scholastically challenged schoolchildren. This paper suggests that proper school-feeding programs and nutrition education programs, which integrate government ministries, teachers, children and parents, should be developed to improve the physical and cognitive health status of Egyptian schoolchildren. PMID:16075578

  14. Egyptian mummies record increasing aridity in the Nile valley from 5500 to 1500 yr before present

    Science.gov (United States)

    Touzeau, Alexandra; Blichert-Toft, Janne; Amiot, Romain; Fourel, François; Martineau, François; Cockitt, Jenefer; Hall, Keith; Flandrois, Jean-Pierre; Lécuyer, Christophe

    2013-08-01

    Oxygen isotope compositions were measured in teeth (n=29) and bones (n=41) from Egyptian mummies of humans (n=48) in order to track the ?18O evolution of the Nile from 5500 to 1500 B.P. The combination of ?18O values of apatite carbonate and phosphate was used to filter the database for post mortem alteration of bioapatites, while 87Sr/86Sr ratios were used to detect potential allochthonous people buried in the various archeological sites located along the Nile. This approach led to only five apatite samples out of seventy to be discarded from the database. The remaining oxygen isotope compositions of both tooth and bone phosphates from ancient Egyptians were converted into the composition of ingested water ultimately originating from the Nile. It was found that ?18O of Nile waters increases progressively from -1.6 to +1.5 (‰ VSMOW) from the Predynastic (?5500 B.P.) through the Late Period (?2550 B.P.). This trend towards higher Nile ?18O values acquired in more recent times is coherent with a general drying trend in Northeast Africa, which was not limited to a drying spell at the end of the Nabtian Pluvial (ca. 12,000 B.P. -ca. 6000 B.P.), but extended far into the following millennia nearly to the beginning of the Common Era (1950 B.P.).

  15. Effects of ?2-adrenergic receptor polymorphisms on asthma severity and response to salbutamol in Egyptian children

    Directory of Open Access Journals (Sweden)

    Khaled Saalah

    2012-10-01

    Full Text Available Background: Several polymorphisms of the ?2-adrenergic receptor (ADRB2 gene have been identified. There is mounting evidence that these polymorphisms are associated with significant variability in response to bronchodilator therapy and thus in severity and duration of asthmatic symptoms. Objectives: to assess the frequency of ADRB2 polymorphisms at codon 16 in Egyptian asthmatic children and to study the association of these polymorphisms with asthma severity and response to inhaled salbutamol. Methods: This case-control study was conducted at pulmonology unit, Zagazig University children’s hospital during the period from December 2010 to December 2011. One hundred children (50 asthmatics and 50 controls were enrolled into the study. For all study population, detailed history taking, systematic physical examination, chest x-ray, pulmonary function testing and ADRB2 genotyping were performed. Results: There was a significant increase in frequencies of Arg/Gly and Gly/Gly genotypes among asthmatic children in comparison with healthy controls (OR = 7.9; CI: 0.94-67.4, P0.05. Regarding bronchodilator responsiveness, Gly/Gly and Arg/Gly genotypes were associated with reduced response, while Arg/Arg genotype was associated with favorable response to nebulized salbutamol. Conclusion: Polymorphisms of ADRB2 at codon 16 may be a determinant of asthma severity and response to salbutamol in Egyptian asthmatic children. Further studies are needed to demonstrate effects of other polymorphisms of ADRB2 gene on these outcomes.

  16. Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in chronic myeloid leukemia: an Egyptian study.

    Science.gov (United States)

    Khorshied, Mervat Mamdooh; Shaheen, Iman Abdel Mohsen; Abu Khalil, Reham E; Sheir, Rania Elsayed

    2014-01-01

    Methylenetetrahydrofolate reductase (MTHFR) gene plays a pivotal role in folate metabolism. Several genetic variations in MTHFR gene as MTHFR-C677T and MTHFR-A1298C result in decreased MTHFR activity, which could influence efficient DNA methylation and explain susceptibility to different cancers. The etiology of chronic myeloid leukemia (CML) is obscure and little is known about individual's susceptibility to CML. In order to assess the influence of these genetic polymorphisms on the susceptibility to CML and its effect on the course of the disease among Egyptians, we performed an age-gender-ethnic matched case-control study. The study included 97 CML patients and 130 healthy controls. Genotyping of MTHFR-C677T and -A1298C was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The results showed no statistical difference in the distribution of MTHFR-C677T and -A1298C polymorphic genotypes between CML patients and controls. The frequency of MTHFR 677-TT homozygous variant was significantly higher in patients with accelerated/blastic transformation phase when compared to those in the chronic phase of the disease. In conclusion, our study revealed that MTHFR-C677T and -A1298C polymorphisms could not be considered as genetic risk factors for CML in Egyptians. However, MTHFR 677-TT homozygous variant might be considered as a molecular predictor for disease progression. PMID:24338216

  17. Establishment of an absolute chronology for the 18th Egyptian Dynasty

    International Nuclear Information System (INIS)

    The establishment of an absolute chronology for Ancient Egypt is an ambition which has concentrated efforts of many scholars since the beginning of Egyptology. Thanks to historical and archaeological documents, a relative chronology of the kings has been built. Only some astrophysical points and synchronisms listed in texts (Greek and Egyptian sources) have given some ankle points which have led to some propositions of absolute chronology. At first, we will see how we can re-calculate some ankle points by using Sothic dating and modelling lunar dates with a Bayesian approach. Then, radiocarbon measurements have been done at Laboratoire de Mesure du Carbone 14 (CEA Saclay) on Egyptian short life materials like plants or twigs. These objects come from the Louvre Museum and are attributed to a particular reign and a precise period. With a Bayesian approach, these analyses have been combined with the known succession and length of the reign. Besides, Sothic and lunar dates have been incorporated as a prior in the model. It has led to propose an absolute chronology for the 18th dynasty. Finally, we will discuss the agreement between our results and archaeological evidence and will see if this chronology can highlight points where Egyptologists disagree. (author)

  18. Biochemical Markers Of Bone Turnover in Egyptian Women at Different Ages

    Directory of Open Access Journals (Sweden)

    Olfat A Khalil &Kholoud S Ramadan

    2011-07-01

    Full Text Available Osteoporosis is a metabolic bone disease characterized by bone remodeling .This study was done for the detection of some blood and urine markers in cases of osteoporosis among Egyptian women at different ages .The study included 100 women divided into three groups. The first group included 33 women their ages ranged between 35-45 years old, the second included 33 women their ages ranged between 45-55 years old and the third group included 34 women their ages were above 55 years old. Fore all subjects DEXA densitometry was performed. Serum calcium, phosphorous, alkaline phosphatase, Osteocalcin and urinary hydroxyproline, deoxypyridinoline and creatinine were estimated. Results: In osteopenic and osteoporotic women there was elevation in serum alkaline phosphatase and osteocalcin and in urinary pyridinoline and hydroxyproline, while there was decrease in serum calcium .Conclusion: The Egyptian women subjected to the study were suffering from osteopenia from the age of 35 years old or may be earlier Above the age of 55 (postmenopausal it was found that 50% of women were osteopenic and osteoporotic.

  19. EGYPTIAN LICENSE PLATE RECOGNITION USING ENHANCED STROKE WIDTH TRANSFORMATION AND FUZZY ARTMAP

    Directory of Open Access Journals (Sweden)

    Alaa Mohamed Youssef

    2014-01-01

    Full Text Available License Plate Recognition (LPR is the most important type of Intelligent Transportation System (ITS. LPR is used in many different types of ITS like electronic payment systems, toll station, parking fees, freeway and arterial management systems for traffic surveillance. Few years ago, Egyptians government changed the car license plate to include letters and numbers. So the needs for efficient LPR System for the new license plate are increased in different ITS fields. This study presents an enhanced LPR detection algorithm for the new Egyptian licenses plate. The detection enhancement is done using Stroke Width Transform algorithm to extract letters from candidate areas combined with Fuzzy ARTMAP classifier. Stroke Width Transform (SWT is a state of art algorithm developed by Microsoft Research Lab for detecting text in natural scene, it seeks to find the value of stroke width for each image pixel and demonstrate its use on the task of text detection in natural images. This study is focusing on detecting Arabic letters in the candidate license plate area using SWT image map instead of binary image map where not all Arabic letters have uniformly stroke width and some letters have a dot above and below it. The proposed model shows 26% detection accuracy enhancement than conventional LPR systems (Sobel Edge detection with binary image map using template matching technique.

  20. Egyptian Revolution of 2011 and the Power of Its Slogans: A Critical Discourse Analysis Study

    Directory of Open Access Journals (Sweden)

    Khaled Al Masaeed

    2013-12-01

    Full Text Available Egypt, the most populated country in the Arab world, erupted in mass protests in January 2011 against the oppressive rule of President Hosni Mubarak. Protesters all over Egypt in general and in Tahrir Square in Cairo wanted Mubarak to leave. Protesters used different dialects, languages, and modes to get their message across. After 18 days of angry protests and after losing the support of the military and the US, Mubarak finally understood the message and resigned on Feb. 11, ending almost 30 years of dictatorial rule. This article builds on studies in Critical Discourse Analysis (CDA and its implementation of interdisciplinarity to investigate the slogans?fixed expressions, usually chosen carefully by organizers and activists, which are often chanted by political groups and protestors at demonstrations that were used during the Egyptian revolution in late January and February 2011. Moreover, the article shows how CDA?through embracing text as a dialogue and site for interaction, social goods and social languages, interpersonal relations and discourse, multimodality, and intertextuality can help to produce theoretically sound interpretation that is appropriate for the analysis of how Egyptians used the power of language through these slogans to empower themselves, challenge their government, and overthrow the former president Hosni Mubarak.