A multi-centre evaluation of the test strip analyser, Rapimat, was performed by four laboratories following the ECCLS 2nd draft guidelines for the evaluation of analysers in clinical chemistry. Using the Rapignost urine test strip with the test fields for bilirubin, urobilinogen, acetoacetate, ascorbic acid, glucose, protein, nitrite, pH and haemoglobin, the Rapimat was found to be analytically reliable in comparison with other, in most cases quantitative procedures. During the observation period of about 6 months no breakdown occurred in any laboratory. Interferences and sensitivity as discussed for the bilirubin and urobilinogen test field are more related to the test strip than to the instrument. Several improvements for further developments are suggested. This multi-centrestudy has shown that the ECCLS protocol is applicable to analytical procedures leading to discrete results. PMID:4056663
IntroductionFlow diversion is a new approach to the endovascular treatment of intracranial aneurysms which uses a high density mesh stent to induce sac thrombosis. These devices...Full Text Available
BackgroundMeropenem is a carbapenem that has an excellent activity against many gram-positive and gram-negative aerobic, facultative, and anaerobic bacteria. The major objective...Full Text Available
Abstract Background: This study involves a multicentre surveillance of tigecycline and tetracycline activity against Gram-negative and Gram-positive bacteria from primary care centres (PCCs), general hospital wards (GHWs) and intensive care units (ICUs) in Denmark (n == 9), Finland (n == 10), Norway (n == 7) and Sweden (n == 19). Methods: The hospitals were each asked to test 30 consecutive Gram-positive and 30 Gram-negative clinical isolates. Supportive information accompanying each isolate included the study centre, ward level (PCC, GHW, or ICU), patient identification and source of the isolate. Minimum inhibitory concentrations (MICs) for tetracycline and tigecycline were determined with the Etest. Results: The isolates collected comprised 1610 Gram-negative and 1767 Gram-positive clini...
Major depressive disorder and alcohol dependence are common and serious mental illnesses. There is a great interest in discovering useful treatments for both mood symptoms and alcohol abuse in those patients with depressive disorders and comorbid alcohol dependence. The primary purpose of this study was to evaluate the effectiveness and tolerability of mirtazapine for the treatment of patients with alcohol dependence comorbid with a depressive disorder in an open label, naturalistic multicentre treatment setting. The 17-item Hamilton Depression Rating Scale (HDRS), the Hamilton Anxiety Rating Scale (HARS) and the Clinical Global Impression-Severity (CGI-S) scale were measured at baseline and at weeks 4 and 8 for the assessment of treatment effectiveness. Alcohol craving was measured using ...
Summary Background:- Cholinesterase inhibitors form the mainstay of treatment for persons with mild-to-moderate Alzheimer-s disease (AD). The rivastigmine patch may increase compliance and the proportion of patients maintaining an efficacious dose compared with oral cholinesterase inhibitors. Objective:- To investigate the proportion of patients who reached and maintained the target rivastigmine patch dose compared with the target rivastigmine capsule dose reported in clinical trials. Methods:- This was a multicentre, 24-week, open-label study in persons with probable AD and a Mini-Mental State Examination (MMSE) score of --10 and --26. The primary outcome was the proportion of patients (ITT population) treated with 9.5-mg/24-h rivastigmine patch for at least 8-weeks at week 24. Secondary ...
After baseline studies, 21 patients with osteoporosis were treated with human parathyroid hormone fragment (PTH 1-34) given as once-daily subcutaneous injections for 6-24 months. The dose used did not...Full Text Available
The epithermal cross section shielding methods used in the lattice physics code EPRI-CELL (E-C) have been extensively studied to determine its major approximations and to examine the sensitivity of computed results to these approximations. The study has resulted in several improvements in the original methodology. These include: treatment of the external moderator source with intermediate resonance (IR) theory, development of a new Dancoff factor expression to account for clad interactions, development of a new method for treating resonance interference, and application of a generalized least squares method to compute best-estimate values for the Bell factor and group-dependent IR parameters. The modified E-C code with its new ENDF/B-V cross section library is tested for several numerical benchmark problems. Integral parameters computed by EC are compared with those obtained with ...
Erosion-corrosion (E-C) of 3003 aluminum (Al) alloy in ethylene glycol-water solutions were studied by weight-loss and electrochemical measurements as well as surface characterization through an impingement jet system. Al alloy E-C is dominated by erosion components, i.e., pure erosion and corrosion-enhanced erosion, which account for 92-97% of the total E-C rate under the various conditions in this work. Contribution from corrosion components, including pure corrosion and erosion-enhanced corrosion, is slight. With the increase of fluid flow velocity and sand concentration, the total E-C rate increases. Compared with the significant increase of the rates of erosion components, the increase of the rate of corrosion component is negligible. Upon fluid flow, passivity of Al alloy that develo...
Background: The outcome of acute myocardial infarction (AMI) complicated with cardiogenic shock is poor. The aim of this study was to analyse, whether upfront abciximab administration could improve the outcomes of cardiogenic shock. Methods: This multicentre open trial randomized 80 patients with AMI complicated by cardiogenic shock expected to undergo primary PCI into group A (routine upfront-pre-procedural-abciximab bolus followed by 12-h abciximab infusion) and group B (standard therapy). The study primary objective was 30-day combined outcome (death/reinfarction/stroke/new severe renal failure). Results: PCI was technically successful in 90% (A) versus 87.5% (B) patients. Abciximab was used in 100% (A) versus 35% (B). The primary endpoint occurred in 17 group A patients (42.5%) and 11 ...
Transplantation has emerged as the therapy of choice for many patients with end organ failure. One of the major goals is to tailor immunosuppressive therapy to the individual needs of every patient to balance the risk for rejection and over-immunosuppression. This will require diagnostic tools that can detect harmful processes in the allograft early, and that can be measured repeatedly. This review will consider recent advances in our understanding of the molecular nature of these processes and how this information is being utilized to design novel diagnostic assays to non-invasively monitor allografts. Highlighted is the need for large-scale prospective multi-centrestudies to validate assays that show early promise in single centre studies.
The aim of the paper is brief description of the present state and main results of investigations on the direct energy conversion (EC). The following EC development directions are considered: thermoelectric EC, thermionic EC, thermophotovolt EC, magnetohydrodynamic-dynamic EC, nuclear-optical EC, plasma-chemical EC and electrochemical EC (hydrogen power engineering
A multicentre evaluation of the urine test strip analyser Super Aution-4220 was carried out in six laboratories. The analytical performance of the instrument with regard to imprecision, linearity, detection limit, drift, carry-over and method comparison was studied. Using the Aution stick 8 test strip the pH, glucose, protein, ketones, bilirubin, blood, urobilinogen and leukocyte esterase were analysed. Specific gravity measurements were performed by refractive index method. Within-run and between-run imprecision determined at three levels of analyte were good. No carry-over was observed. Obtained results were linear through all the described analytical range. No significant drift was detected. Method comparison with some quantitative methods was performed and showed a good correlation with most of the analytes. The study of interferences showed minor interferences by common therapeutic drugs with the measurement of some ...
As part of the study of cytokinin metabolic pathways, an enzyme, adenosine phosphorylase (EC 2.4.2.-), which catalyzed the ribosylation of N6-(Δ2-isopentenyl)adenine,...Full Text Available
The thermal stability of wood polymer composites made with extractive-free wood from four different wood species was studied. Hot water (HW) extractives, ethanol/cyclohexane (E/C) extractives and both types of extractives were eliminated from A. cyclops, E. grandis, P. radiata and Q. alba. Composites of LLDPE and 10 wt% of wood were prepared, using poly vinyl alcohol-co-ethylene (EVOH) as a compatibilizer. The thermal degradation behavior of the composites was characterized with thermogravimetric analysis (TGA). The obtained results showed that in all cases, the degradation temperatures shifted to higher values after removal of the extractives. The removal of E/C extractives was less effective in its improvement of the thermal stability than the removal of HW extractives. The largest improvement on the thermal stability of WPCs was achieved when both types of extractives (E/C and HW) were removed.
BackgroundIn order to evaluate the safety of acupuncture in China objectively, we investigated the adverse events associated with acupuncture based on three multicentre randomized...Full Text Available
Objectives: Evaluate the effect of diet, physical exercise, and a daily oral intake of a soy isoflavones extract (Fisiogen) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daidzein and 3.2mg of glicitein) on leptin and other adipokines plasma levels in healthy obese postmenopausal women. Methods: A multicentric randomized longitudinal prospective cohort study was conducted in a sample of 87 healthy obese postmenopausal women. Patients were randomly assigned to a 1200kcal diet and exercise group (control group) or a group of 1200kcal diet, exercise, and daily oral intake of daily oral intake of a soy isoflavones extract (Fisiogen) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daid...
Following the Chernobyl accident of April 1986, there has been a continual increase in the numbers of reported cases of childhood thyroid carcinoma. An EC-supported consortium to study the pathology and molecular biology of the thyroid cancers is being coordinated from the University of Cambridge. This paper reports the findings of this study so far, together with its recommendations for further studies. (author).
Polyacrylonitrile (PAN)-based polymer electrolytes have obtained considerable attention due to their fascinating characteristics such as appreciable ionic conductivity at ambient temperatures and mechanical stability. This study is based on the system PAN-ethylene carbonate (EC)-propylene carbonate (PC)-lithium trifluoromethanesulfonate (LiCF3SO3). The composition 15 mol% PAN-42 mol% EC-36 mol% PC-7 mol% LiCF3SO3 has shown a maximum room temperature conductivity of 1.2 x 10(-3) stop S cm(-1) stop. Also, it was possible to make a thin, transparent film out of that composition. Cells of the form, Li/PAN-EC-PC-LiCF3SO3/polypyrrole (PPy)-alkylsulfonate (AS) were investigated using cyclic voltammetry and continuous charge-discharge tests. When cycled at low scan rates, a higher capacity could be obtained and well-defined peaks were present. The appearance of peaks elucidates the fact that redox reactions ...
Six commercial insecticides viz., decis 25EC (deltamethrin), thiodan 35EC (endosulfan), curacron 500EC (profenophos), somialfa 110EC (esfenvalerate), denitol 30EC (fenpropathrin) and advantage 20EC (carbosulfan) were tested with recommended doses against first instar larvae of cotton bollworm, Helicoverpa armigera (Hub.) to determine their degree of toxicity under controlled laboratory conditions. Leaf dip method was applied for these tests. Insect mortality was assessed after 24, 48 and 72 hours of insecticide application. Results showed that curacron 500EC gave significantly high mortality of 100 % after 24 hours of application followed by thiodan 35EC, somialfa 110EC and advantage 20EC causing 93, 80 and 72 % mortality, respectively. Whereas, denitol 30EC ...
ResumeObjectif determiner dans une etude randomisee l'impact d'un enregistrement continu du glucose sous-cutane pendant 48 heures sur le controle glycemique trois mois plus tard chez des patients presentant un diabete de type 1 (DT1) ou de type 2 (DT2). Methodes Quarante-huit patients avec un mauvais equilibre glycemique (HbA1c : 8-10,5 %) ont beneficie d'un enregistrement continu du glucose sous-cutane pendant 48 heures avec le systeme GlucoDay (A. Menarini Diagnostics) et ont ete randomises en deux groupes : ajustement de traitement en fonction de l'autosurveillance glycemique capillaire (groupe ASG) ou du profil d'enregistrement continu du glucose sous-cutane (groupe CGM). Le dosage d'HbA1c et le port du GlucoDay ont ete renouveles trois mois plus tard. Resultats Trente-quatre patients ...
Rationale Receptor occupancy study has been performed to evaluate pharmacokinetic profiles in new antipsychotic drug development. While these findings highlight the value of positron emission tomography (PET) for dose-finding study, what is unclear is if it is necessary to conduct these studies in patients with schizophrenia or whether studies in healthy volunteers are adequate. Objectives To determine if it is necessary to conduct dopamine receptor occupancy studies in patients with schizophrenia or whether studies in healthy volunteers are adequate for dose-finding study, we compared the concentration?occupancy relationship in terms of EC50 between patients and healthy volunteers. Methods Ten healthy volunteers and eight patients with schizophrenia participated in the study. We measured ...
The aim of this study was to evaluate cucurbitacins (Cucs) liver protective activity in vitro and conduct QSAR studies against lipophilicity and ab initio descriptors. Nine Cucs were isolated from Cucurbitaceae plants and eight prepared by C2-alkylation or C16-acylation. Ten Cucs demonstrated protective activity on human hepatocyte-derived HepG2 cells exposed to CCl4 (EC50=2.4-45.3mM) with good margin to toxicity (T/A). All Cucs exhibited anti-proliferative effect on serum-activated rat stellate cells, HSC-T6 (EC50=0.02-4.12mM) with high T/A. While silybin is nontoxic, its protection is lower compared to Cuc D (3), iso-D (4), I (5), B (11), E (12), I-Me (6), L-Me (7), and E-Me (13) on both cell lines. Strong correlations were found for lipophilicity with both protection and toxicity on Hep...
Most breast cancers are multicentric in origin. They drain into two primary lymphatic depots—the axilla and internal mammary chain of nodes. The incidence of metastasis to the internal mammary...Full Text Available
The walleye dermal sarcoma is a mesenchymal tumor which seasonally affects up to 27% of adult walleye fish (Stizostedion vitreum). It arises multicentrically in the dermis, in which its development...Full Text Available
Quality research, requiring large numbers of participants, in the intensive care unit (ICU) population requires multicentre collaboration. Although logistically challenging, this methodology reduces...Full Text Available
Cerebral blood flow (CBF) and cerebrovascular reserve capacity (CRC) were measured by stable xenon computerized tomography (Xe-CT) and acetazolamide test in 15 patients with cerebrovascular disease before and after extracranial-intracranial (EC-IC) bypass surgery for minor stroke, reversible ischemic neurological deficit or transient ischemic attack. All had angiographically shown occlusive lesions of the major arterial trunk. In the present series, global analysis showed that the bypass did not increase the resting rCBF, but did increase the rCRC. We divided the patients into four groups according to the preoperative resting rCBF and rCRC. All 3 patients with normal resting rCBF and reduced rCRC showed postoperative improvement of rCRC. Of 6 patients with reduced CBF and reduced CRC, three had postoperative increase in resting CBF and four had increased CRC. One of two patients with reduced CBF and normal CRC showed only an increase in CRC. We propose that reduced ...
Evidence from twin, adoption, and family studies suggests that there is strong aggregation of suicidal behaviors in some families. By comparison, the role of social modeling through peers has yet to be convincingly established. This paper uses data from four large studies (the WHO/EURO MulticentreStudy on Suicidal Behaviour, the WHO/SUPRE-MISS, the CASE study, and the Queensland Suicide Register) to compare the effects of exposure to fatal and nonfatal suicidal behavior in family members and nonfamilial associates on the subsequent suicidal behavior of male and female respondents of different ages. Across all studies, we found that prior suicidal behaviors among respondents' social groups were more important predictors of suicidal behavior in the respondents themselves than previous research had indicated. Community-based suicide attempters in the WHO ...
The energy level schemes of /sup 192/Os and /sup 192/Pt have been established on the basis of ..gamma..-..gamma.. coincidence studies using a dual parameter data collection system. Ge(Li) detectors were employed to study the gamma spectra produced in the E.C. and ..beta../sup -/ decays of /sup 192/Ir to /sup 192/Os and /sup 192/Pt, respectively. Thirteen new transitions and three new levels at 1146.95, 1237.35 and 1913.76 keV are suggested. Relative intensities from singles measurements, branching ratios, ..cap alpha..(K) and log ft values were calculated and multipolarities, spins and parities deduced. Comparisons are made with predictions of the Interacting Boson Model calculated on the basis of an O(6) to SU(3) transition.
The energy level schemes of "1"9"2Os and "1"9"2Pt have been established on the basis of #gamma#-#gamma# coincidence studies using a dual parameter data collection system. Ge(Li) detectors were employed to study the gamma spectra produced in the E.C. and #beta#"- decays of "1"9"2Ir to "1"9"2Os and "1"9"2Pt, respectively. Thirteen new transitions and three new levels at 1,146.95, 1,237.35 and 1,913.76 keV are suggested. Relative intensities from singles measurements, branching ratios, #alpha#(K) and log ft values were calculated and multipolarities, spins and parities deduced. Comparisons are made with predictions of the Interacting Boson Model calculated on the basis of an O(6) to SU(3) transition. (orig.).
E-cadherins belong to a family of membrane-bound, cellular adhesion proteins. Their adhesive properties mainly involve the two N-terminal extracellular domains (EC1 and EC2). The junctions between these...Full Text Available
Energy use patterns and utilisation efficiencies in 40 factories producing palm kernel oil (PKO) in southwestern part of Nigeria were studied. The factories were stratified into small, medium and large scale categories based on the mode of operations and production capacities. Questionnaires were administered on the factories to obtain historical data on petrol, diesel and electricity consumption and PKO production outputs for seven years (1998-2004). Energy use efficiency indicators employed include: energy intensity (EI), energy cost per unit product (EC/P), energy ratio (ER), food energy ratio (FER) and percentage oil yield by weight. Results of the study indicated that averagely, 0.58, 0.53 and 0.74GJ/103l of PKO were needed in the small, medium and large PKO factories, respectively. T...
Previous studies indicate that the hatching success of brine shrimp (Artemia franciscana) cysts is surprisingly sensitive to ambient metal concentrations. These studies estimated median effective concentrations (EC50s) of 7, 5, and 28??g l?1 for Cd, Cu, and Zn, suggesting that the hatching end point for A. franciscana is the most sensitive tested to date for Cd and Zn in saline environments and comparable in sensitivity with the most sensitive tested to date for Cu. Furthermore, these data suggest that brine shrimp are at significant risk from Cu and Zn in Great Salt Lake (GSL), UT, where ambient concentrations as high as 10 and 14??g l?1, respectively, have been measured. Given that brine shrimp appear to be successfully reproducing in GSL, we hypothesized that these toxicity values were ...
...htm Waste Framework Directive 75/442/EEC (amended by Directive 91/156/EEC) and Waste Management Planning http://ec.europa.eu/environment/waste/plans/index.htm Selected EC commissioned/supported projects including LCA IPP Pilot Product exercise on mobile phones and on tropical garden furniture http://ec.europa.eu/environment/ipp/pilot.htm \\
The extent measurement error on CT colonography influences polyp categorisation according to established management guidelines is studied using twenty-eight observers of varying experience to classify polyps seen at CT colonography as either 'medium' (maximal diameter 6-9 mm) or 'large' (maximal diameter 10 mm or larger). Comparison was then made with the reference diameter obtained in each patient via colonoscopy. The Bland-Altman method was used to assess agreement between observer measurements and colonoscopy, and differences in measurement and categorisation was assessed using Kruskal-Wallis and Chi-squared test statistics respectively. Observer measurements on average underestimated the diameter of polyps when compared to the reference value, by approximately 2-3 mm, irrespective of observer experience. Ninety-five percent limits of agreement were relatively wide for all observer groups, and had sufficient span to encompass ...
The present study was carried out to exploit the feasibility of using polymeric nanosponges as an alternative carrier for targeting econazole nitrate (EN) to the skin through topical hydrogel formulation. Nanosponges prepared by emulsion solvent diffusion method were evaluated for various physicochemical parameters and in vitro drug release. The nanosponges of EN were discrete free flowing nanosized particles with perforated orange peel like morphology as visualized by SEM. The nanosponge formulated using PVA:EC (3:2) displayed highest in vitro release after 12 ?h in phosphate buffer (pH 6.8) that fitted matrix model. Selected nanosponge was formulated as Carbopol 934 NF hydrogel using varying concentrations of permeation enhancers propylene glycol and N-methyl-2-pyrrolidone. The EN nanosp...
We previously reported that puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) is required for vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis and for endothelial differentiation from embryonic stem (ES) cells via the aminopeptidase activity of PILSAP. In this study, we searched for molecules that function during angiogenesis with PILSAP. We performed proteome analysis of nuclear extracts from embryoid bodies (EBs) made from ES cells transfected with mutant PILSAP lacking aminopeptidase activity and mock EBs. We identified pigpen, a 67-kDa nuclear coiled body component protein. Immunoprecipitation and western blotting demonstrated the binding of PILSAP and pigpen in endothelial cells (ECs), and this interaction was enhanc...
This study explores the use of photosensitizers and reactive oxygen species (ROS) to limit growth of cyanobacteria. We chose 12 phthalocyanines, tetraphenol porphyrine, and methylene blue as compounds producing singlet oxygen. Hydrogen peroxide was chosen as another source of ROS. These compounds were tested using algal toxicity tests in microplates on three cultures of green algae (Pseudokirchneriella subcapitata, Scenedesmus quadricauda, and Chlorella kessleri) and on three cultures of cyanobacteria (Synechococcus nidulans, Microcystis incerta, and Anabaena sp.). Results indicate that photosensitizers and singlet oxygen could be highly toxic for some selected phytoplankton species. Green alga Scenedesmus quadricauda was highly sensitive (EC50 = 0.07 mg/L) to compounds producing singlet o...
The energy level schemes of {sup 152}Gd and {sup 152}Sm have been established on the basis of single gamma-spectra, and gamma-gamma coincidence measurements. Ge(Li) detectors were used to study the gamma spectra produced in the EC/beta{sup +} and beta{sup -} decays of {sup 152}Eu to {sup 152}Sm and {sup 152}Gd, respectively. Thirteen new transitions are reported and data from eleven coincidence gates enabled five new levels to be suggested. Relative intensities and log ft values were calculated and spin/parities deduced. Comparisons are made with new predictions of the Interacting Boson Model. (orig.).
The energy level schemes of "1"5"2Gd and "1"5"2Sm have been established on the basis of single #gamma#-spectra, and #gamma#-#gamma# coincidence measurements. Ge(Li) detectors were used to study the gamma spectra produced in the EC/#beta#"+ and #beta#"- decays of "1"5"2Eu to "1"5"2Sm and "1"5"2Gd, respectively. Thirteen new transitions are reported and data from eleven coincidence gates enabled five new levels to be suggested. Relative intensities and log ft values were calculated and spin/parities deduced. Comparisons are made with new predictions of the Interacting Boson Model. (orig.).
Green crab (Scylla serrata) alkaline phosphatase (EC 3.1.3.1) is a metalloenzyme, which catalyzes the nonspecific hydrolysis of phosphate monoesters. The kinetics of inhibition of the enzyme by sodium (2, 2'-bipyridine) oxodiperoxovanadate, pV(bipy), has been studied. The time course of the hydrolysis of p-nitrophenyl-phosphate catalyzed by the enzyme in the presence of different pV(bipy) concentrations showed that at each pV(bipy) concentration, the rate decreased with increasing time until a straight line was approached, the straight line slopes are the same for all concentrations. The results suggest that the inhibition of the enzyme by pV(bipy) is a slow, reversible reaction with fractional remaining activity. The microscopic rate constants are determined for the reaction of inhibitor with the enzyme. PMID:10691182
Withania somnifera (L.) Dunal (Family, Solanaceae), commonly known as Ashwagandha is one of the most valuable medicinal plants synthesizing large number of pharmacologically active secondary metabolites known as withanolides. Though the plant has been well characterized in terms of phytochemical profiles as well as pharmaceutical activities, not much is known about the genes responsible for biosynthesis of these compounds. In this study, we have characterized a gene encoding farnesyl diphosphate synthase (FPPS; EC 2.5.1.10), a key enzyme in the pathway of biosynthesis of isoprenoids, from W. somnifera. The full-length cDNA of Withania somnifera FPPS (WsFPPS) of 1,253?bps encodes a polypeptide of 343 amino acids. The amino acid sequence homology and phylogenetic analysis suggest that WsFPPS...
Radioiodinated carbohydrates such as 2-deoxy-2-iodo-D-glucose and 3-deoxy-3-iodo-D-glucose undergo facile chemical or in vivo deiodination which precludes their use as radiotracers of glucose metabolism in tissues. To overcome the problems resulting from in vivo deiodination, we explored the concept of stabilizing radioiodide on a model carbohydrate, (E)-C-3-iodovinyl-D-allose (10) as an iodovinyl moiety. This agent did not exhibit brain specificity but showed low in vivo deiodination which demonstrated for the first time that radioiodide can be stabilized on a carbohydrate. The goal of this study was to develop a deoxy-branched carbohydrate with radioiodide stabilized as a vinyliodide with the objective of achieving high brain uptake. 10 refs., 1 fig., 1 tab.
Radioiodinated carbohydrates such as 2-deoxy-2-iodo-D-glucose and 3-deoxy-3-iodo-D-glucose undergo facile chemical or in vivo deiodination which precludes their use as radiotracers of glucose metabolism in tissues. To overcome the problems resulting from in vivo deiodination, we explored the concept of stabilizing radioiodide on a model carbohydrate, (E)-C-3-iodovinyl-D-allose as an iodovinyl moiety. This agent did not exhibit brain specificity but showed low in vivo deiodination which demonstrated for the first time that radioiodide can be stabilized on a carbohydrate. The goal of this study was to develop a deoxy-branched carbohydrate with radioiodide stabilized as a vinyliodide with the objective of achieving high brain uptake. (author).
The influence of applied potential on the erosion-corrosion (E-C) behavior of AISI321 stainless steel in 10% H{sub 2}SO{sub 4}+15% corundum sand (60 mesh) acidic slurry was investigated using a modified slurry pot apparatus. The surface morphologies of E-C specimens at various applied potentials were observed by scanning electron microscopy. The results showed that cathodic protection could significantly decrease E-C rate, and the cathodic protection efficiency could be 73.6%. The influence of applied anodic potentials on the E-C behaviors could be classified as the following three types: A. The E-C rate increased sharply in region I (a little more positive than free-corrosion potential); B. The E-C rate decreased significantly in region II (stable passive region), and the anodic protection efficiency could be 64.5%; C. The E-C rate ...
Full text: The maturation of chicken forebrain is protracted and occurs well after synapse formation providing a good model for studying mechanisms of brain maturation. Using microslices from immature (10 day) and adult chicken forebrain prepared after decapitation, we have examined functional properties of NMDA and AMPA receptors by measuring agonist-induced uptake of "4"5Ca"2"+ . The rate and extent of NMDA induced "4"5Ca"2"+ accumulation decreased during maturation with no change in EC_5_0. The rate and extent of the AMPA induced response also decreased with a 60-fold increase in EC_5_0. However, the total NMDA receptor content did not change as indicated by 3 H-MK801 binding and NR1 immunoreactivity in P2 fractions. Similarly, there was no change in the B_m_a_x of "3H-AMPA, though there was a two-fold increase in K_D, and little or no change in the immunoreactivity in GluR1, 2, 2/3 or 4. These results suggest that it is ...
Background: Some former retrospective studies have suggested that patients with Ewing's sarcoma might have a very high risk for developing secondary sarcomas if treated with radiotherapy. We have evaluated the risk of second malignancies (SM) in patients treated in the German Cooperative Ewing's Sarcoma Studies CESS 81 and CESS 86. Materials and methods: From January 1981 through June 1991, a total number of 674 patients was registered in the two multicentric Ewing's sarcoma trials CESS 81 (1981 through 1985) and CESS 86 (1986 through June 1991). The systemic treatment consisted in both studies of a four-drug-chemotherapy (VACA= vincristine, actinomycin D, cyclophosphamide and adriamycin; or VAIA= vincristine, actinomycin D, ifosfamide and adriamycin) and a total number of four courses, each lasting nine weeks, was recommended by the protocol. Local therapy was either complete surgery or surgery plus ...
Two strains of Rhizobium: Rhizobium Tropici and Mesorhizobium Ciceri nodulating respectively common bean and chickpea were treated by gamma irradiation (60Co) source. Radiosensibility analysis showed that 800 Gy was the biggest dose supported by these two strains. We isolated gamma irradiated resistant strain in order to select mutant of them which can supported salt stress and phosphorus deficiency. Salinity analysis showed that Mesorhizobium Ciceri 835 strain, can tolerate up to 18g/l (273 mM NaCl) of salt, whereas, their irradiation mutants tolerate salinity up to 33g/l (564mM. NaCl) Rhizobium Tropici CIAT899 can survive at 20g/l (342 mM) either for control strain or mutants. Analysis of phosphorus deficiency showed that either Rhizobium Tropici CIAT899, or Mesorhizobium Ciceri 835 can survive in medium without phosphore. Our results permit us to screen mutants tolerant to these stresses wide spread in Mediterranean soil. In this study, we choose two mutants ...
The aim of this work was to compare the electrochemical behaviors and safety performance of graphite and the lithium titanate spinel Li1.33Ti1.67O4 with half-cells versus Li metal. Their electrochemical properties in 1 M LiPF6/EC + DEC (1:1 w/w) or 1 M LiPF6/PC + DEC (1:1 w/w) at room and elevated temperatures (30 and 60 deg C) have been studied using galvanostatic cycling. At 30 deg C graphite has higher reversible capacity than Li1.33Ti1.67O4 when using the LiPF6/EC + DEC as electrolyte. At 60 deg C graphite declines in cell capacity yet Li1.33Ti1.67O4 remains almost unchanged. In a propylene carbonate (PC) containing electrolyte, graphite electrode exfoliates and loses its mechanical integrity while Li1.33Ti1.67O4 electrode is very stable. An accelerating rate calorimeter (ARC) and microcalorimeter have been used to compare the thermal stability of lithiated lithium titanate spinel and graphite. Results show that ...
In order to test the sensitivity of the sperm cell of the mud crab Scylla serrata to heavy metals, the toxic effects of Ag+, Cd2+, Cu2+, and Zn2+ on the acrosome reaction (AR) were studied by artificially inducing the AR of sperm exposed to heavy metals, counting the AR rates by light microscopy, and observing structural changes in sperm by transmission electron microscopy. The AR in S. serrata occurs at two stages. The first stage (ARI) is the eversion of the subacrosomal material. The second stage (ARII) is the ejection of the acrosomal filament. The results showed the EC50 values of the AR based on (ARI + ARII)% for Ag+, Cd2+, Cu2+, and Zn2+ were 10.02, 2.14, 13.69, and 2.21 microg/L, and the EC50 values based on ARII % of Ag+, Cd2+, Cu2+, and Zn2+ were 1.96, 0.20, 1.46, and 0.34 microg/L. The order of toxicity is Cd2+ > Zn2+ > Cu2+ > Ag+ based on the percentage of reacted sperm at the second stage. Sperm cells ...
Diffusion in the extracellular space (ECS) of the brain is constrained by the volume fraction and the tortuosity and a modified diffusion equation represents the transport behavior of many molecules...Full Text Available
The bifunctional rat liver enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (ATP:D-fructose-6-phosphate 2-phosphotransferase/D-fructose-2,6-bisphosphate 2-phosphohydrolase, EC 2.7.1.105/EC...Full Text Available
Recent research has shown that biologically inspired approaches to materials synthesis and self-assembly, hold promise of unprecedented atomic level control of structure and interfaces. In particular, the use of organic molecules to control the production of inorganic technological materials has the potential for controlling grain structure to enhance material strength; controlling facet expression for enhanced catalytic activity; and controlling the shape of nanostructured materials to optimize optical, electrical and magnetic properties. In this work, we use organic molecules to modify silver crystal shapes towards understanding the metal-organic interactions that lead to nanoparticle shape control. Using in situ electrochemical AFM (EC-AFM) as an in situ probe, we study the influence of a cationic surfactant cetyltrimethylamminobromide (CTAB) on Ag growth during electrochemical deposition on Ag(100). The results show that the organic ...
The local density functional theory is used to study the electrical levels and thermal stabilities of complexes of interstitial boron with O and C and a boron dimer with H. The energy levels of these defects are compared with those found from deep level transient capacitance spectroscopy experiments on irradiated p-Si containing B. The levels observed at E_c-0.23, E_v+0.29, and E_v+0.51 eV are assigned to B_iO_i, B_iC_s, and B_iB_sH_i respectively. B_iC_s is passivated by one H atom. Evidence for the existence of B_iC_s has implications for mechanisms involved in the suppression of transient-enhanced diffusion of boron in ion-implanted Si by C.
Partially purified UDPgalactosyltransferase (EC 2.4.1.22) from bovine milk has been used to synthesize millimolar amounts of compounds such as Gal#beta#(1#->#4)Glc, Gal#beta#(1#->#4)GlcNAc-#beta#-hexanolamine, and Gal#beta#(1#->#4)-GlcNAc#beta#(1#->#4)GlcNAc. The same method has been used to prepare similar compounds containing "1"3C-enriched galactopyranosyl moieties. Gal#beta#(1#->#4)GlcNAc-#beta#-hexanolamine was also synthesized in a solid-phase system in which the GlcNAc-#beta#-hexanolamine glycoside was covalently linked to agarose beads. At pH 7.0 and at 1 to 5 mM Mn"2"+"+ the yields of the galactosyl saccharides are greater than 90% by using 10% excess of UDPGal donor. The use of a 90% enriched [1-"1"3C]galactosyl residue allowed the determination of the most abundant conformer about the galactopyranosyl-glycoside linkage by analysis of the carbon-carbon coupling constants from Cl to Gal to the C3', C4', and C5' of GlcNAc or Glc. 3 figures, 1 ...
This project was conducted to evaluate novel approaches for removing radioactive strontium (Sr) and cesium (Cs) from the tank wastes. The bulk of the Sr removal research conducted as part of this project investigated adsorption of Sr onto a novel adsorbent known as iron-oxide-coated sand. The second major focus of the work was on the removal of cesium. Since the chemistries of strontium and cesium have little commonality, different materials (namely, cesium scavengers known as hexacyanoferrates, HCFs) were employed in these tests. This study bridged several scientific areas and yielded valuable knowledge for implementing new technological processes. The applicability of the results extends beyond the highly specialized application niches investigated experimentally to other issues of potential interest for EMSP programs (e.g., separation of chromium from a variety of wastes using IOCS, separation of Cs from neutral and acidic wastes with ...
Basic properties and battery performances of the novel high temperature stable lithium salt (Li{sub 2}B{sub 12}F{sub 12}, Dilithium Dodecafluorododecaborate; Li{sub 2}DFB) were studied using a Mn-based cathode and anode composed of a hard carbon and graphite mixture. The effect of co-solvents (mainly linear carbonate in electrolyte formulation of PC/EC/co-solvent (5/30/65 vol% mixture)) on conductivity, viscosity, charge-discharge capacities, rate performance, temperature performance, cycle life and storage life at 60 C was investigated. Conductivity of Li{sub 2}DFB electrolyte increased with reducing its viscosity by changing co-solvent and increasing the volume of the higher dielectric solvent. Li{sub 2}DFB electrolytes showed comparable discharge capacity and columbic efficiency against LiPF{sub 6} electrolyte. Li{sub 2}DFB electrolytes improved the storage life and cycle life of a Mn-based cell at 60 C. (author)
Purpose: During recent years, more intensified systemic and local treatment regimens have increased the 5-year survival figures in localized Ewing's sarcoma to more than 60%. There is, however, concern about the risk of second malignancies (SM) in long-term survivors. We have analyzed the second malignancies in patients treated in the German Ewing's Sarcoma Studies CESS 81 and CESS 86. Materials and Methods: From January 1981 through June 1991, 674 patients were registered in the two sequential multicentric Ewing's sarcoma trials CESS 81 (recruitment period 1981-1985) and CESS 86 (1986-1991). The systemic treatment in both studies consisted of a four-drug-regimen (VACA = vincristine, actinomycin D, cyclophosphamide, and adriamycin; or VAIA = vincristine, actinomycin D, ifosfamide, and adriamycin) and a total number of four courses, each lasting nine weeks, was recommended by the protocol. Local therapy in curative patients ...
Early recognition of recurrence and work-up of clinically indeterminate lesions may be impaired after reconstruction with silicone implants due to superimposition of the implant or to scarring. This study was undertaken to evaluate the use of contrast-enhanced MRI in patients with silicone implant after breast cancer. Contrast-enhanded MRI was offered to 169 patients. Comparative two- to three-view mammography was also performed in 169 patients, as well as comparative sonography in 144 patients. Conventional imaging and clinical examination detected only 8/13 recurrences, whereas 12/13 were detected by MRI. One recurrence had been visible as a strongly enhancing 2-mm dot in a previous examination (2 years before), but was not called. It was therefore counted as false negative. In addition, multicentricity was detected by MRI alone in two of three cases. MRI correctly diagnosed scar tissue in all cases with indeterminate findings. However, due ...
The chloroplast and cytoplasmic isoenzymes of phosphoglycerate kinase (PGK) (EC. 2.7.2.3) from Hordeum vulgare leaves have been separated and purified for the first time to apparent...Full Text Available
MicroRNAs (miRs) can regulate many cellular functions, but their roles in regulating responses of vascular endothelial cells (ECs) to mechanical stimuli remain unexplored. We hypothesize that the physiological...Full Text Available
Incidence of esophageal cancer (EC) is rising more rapidly in the Western world than that of any other cancer. Despite advances in therapy, more than 50% of patients have incurable disease at the time...Full Text Available
An antiserum was raised in a rabbit against highly purified human liver dihydropteridine reductase (EC 1.6.99.7). Dihydropteridine reductase from human liver, in human cultured fibroblasts and in continuous...Full Text Available
Lithium hexa-fluoro-phosphate LiPF{sub 6} is recommended for the replacement of the toxic LiAsF{sub 6} and the explosive perchlorates (like LiClO{sub 4}) in rechargeable lithium electrochemical generators. The aim of this work is to develop a new method of synthesis of this salt and to check its stability with respect to carbonated solvents: ethylene carbonate (EC), propylene carbonate (PC) and dimethyl-carbonate (DMC) in already optimized EC/DMC and PC/DMC binary mixtures. Two methods using HPF{sub 6} are proposed: the first one uses the direct neutralization of this commercial acid by LiOH in aqueous, alcoholic or acetonitrile environment, while in the second one LiPF{sub 6} is obtained from pyridinium hexa-fluoro-phosphate synthesized from HPF{sub 6} using a new and simple protocol. (J.S.) 24 refs.
The structural properties of brain extracellular space (ECS) are summarised by the tortuosity (λ) and the volume fraction (α). To determine if these two parameters were independent,...Full Text Available
... Optimisation of reactive dye removal by sequential electrocoagulation-flocculation... The removal of Reactive Black 5 dye in an aqueous solution by electrocoagulation (EC) as well... »Read more By M. Mohsen Nourouzi, T. G. Chuah, Thomas S....
The distribution of α-galactosidase (α-d-galactoside galactohydrolase [EC 3.2.1.22]) in Cucurbita pepo has been determined in an attempt to assess its involvement...Full Text Available
Malate synthase (EC 4.1.3.2), an enzyme unique to the glyoxylate cycle, was purified to homogeneity from cotyledons of 72-hours, darkgrown cotton (Gossypium hirsutum L.) seedlings....Full Text Available
Three areas have been investigated: coal liquefaction with supercritical fluids, liquefaction by extraction with high boiling liquid solvents, and the production of resins from coal-derived hydrocarbons. The processes are described.
Tyrosinase or polyphenol oxidase (EC 1.14.18.1) is the key enzyme in melanin biosynthesis and in the enzymatic browning of fruits and vegetables. The role of tyrosinase in the secondary metabolism of...Full Text Available
Acetolactate synthase (EC 4.1.3.18) activity was examined in maize (Zea mays L.) endosperm and embryos as a function of kernel development. When assayed using unpurified homogenates,...Full Text Available
BackgroundThe Emergency Care Summary (ECS) was introduced in 2006 to allow aspects of the general practitioner (GP; family doctor, equivalent to primary care physician) medical record...Full Text Available
BackgroundXMRV (xenotropic murine leukemia virus-related virus) is the first known example of an exogenous gammaretrovirus that can infect humans. A limited number of reports suggest that XMRV is intrinsically resistant to many of the antiretroviral drugs used to treat HIV-1 infection, but is sensitive to a small subset of these inhibitors. In the present study, we used a novel marker transfer assay to directly compare the antiviral drug sensitivities of XMRV and HIV-1 under identical conditions in the same host cell type.ResultsWe extend the findings of previous studies by showing that, in addition to AZT and tenofovir, XMRV and HIV-1 are equally sensitive to AZddA (3'-azido-2',3'-dideoxyadenosine), AZddG (3'-azido-2',3'-dideoxyguanosine) and adefovir. These results indicate that specific 3'-azido or acyclic nucleoside analog inhibitors of HIV-1 reverse transcriptase (RT) also block XMRV infection with comparable efficacy in vitro. Our data ...
Introduction: Development of agonist positron emission tomography (PET) radioligands for the 5-HT neurotransmitter system is an important target to enable the understanding of human 5-HT function in vivo. ["1"1C]CUMI-101, proposed as the first 5-HT_1_A receptor agonist PET ligand, has been reported to behave as a potent 5-HT_1_A agonist in a cellular system stably expressing human recombinant 5-HT_1_A receptors. In this study, we investigate the agonist properties of CUMI-101 in rat brain tissue. Methods: ["3"5S]-GTP#gamma#S binding studies were used to determine receptor function in HEK (human embryonic kidney) 293 cells transfected with human recombinant 5-HT_1_A receptors and in rat cortex and rat hippocampal tissue, following administration of CUMI-101 and standard 5-HT1A antagonists (5-HT, 5-CT and 8-OH-DPAT). Results: CUMI-101 behaved as an agonist at human recombinant 5-HT_1_A receptors (pEC_5_0 9.2). However, ...
Energy use patterns and utilisation efficiencies in 40 factories producing palm kernel oil (PKO) in southwestern part of Nigeria were studied. The factories were stratified into small, medium and large scale categories based on the mode of operations and production capacities. Questionnaires were administered on the factories to obtain historical data on petrol, diesel and electricity consumption and PKO production outputs for seven years (1998-2004). Energy use efficiency indicators employed include: energy intensity (EI), energy cost per unit product (EC/P), energy ratio (ER), food energy ratio (FER) and percentage oil yield by weight. Results of the study indicated that averagely, 0.58, 0.53 and 0.74 GJ/10{sup 3} l of PKO were needed in the small, medium and large PKO factories, respectively. The average food energy ratios in the small, medium and large mills are 2.48, 2.53 and 2.14, respectively. The corresponding ...
A theoretical analysis of formation and symmetry transformations is presented for Wigner molecules with N = 2,..., 20 electrons confined in quantum dots at high magnetic fields. Using the unrestricted Hartree-Fock method with the multicentre Gaussian basis, we have found that Wigner molecules with N {>=} 6 abruptly change their shape and symmetry with an associated jump in the first derivative of the ground-state energy, i.e. they undergo phase transitions. In particular, the phases of the Wigner molecules obtained just after emerging from the maximum-density droplet (MDD) phase possess a different symmetry from that formed at a high magnetic field. We show that the properties of the electron-electron interaction energy demonstrate very well both the breakdown of the MDD and the quasi-classical character of the Wigner molecule in the high magnetic field. Possible mechanisms of the MDD decay are discussed.
The main aim of any food irradiation treatment is to guarantee the best safe quality of the products, reducing the spreading risk ("cross-contamination") for several food-associated diseases. Actually, over 40 countries provide clearances for the treatment of about 45 different types of foodstuffs. EU has to homogenise the situation within the associated States. With the European directive 1999/2/EC Italy, as other EU countries, already has brought into force their regulations to comply. The current Italian regulation on irradiation treatment of foodstuffs is referred since 1996 as follows: a) potatoes, onions and garlic; b) spices, herbs and condiments microbial. The new (April 2001) Italian law allows the possibility to ask for special permission of treatment for other foodstuff which is possible to treat in other E.U. countries. Large majority of foods are submitted to irradiation treatment after they have been packaged. In Dutch cases the ...
Ferroelectric Pb_0_._9_8_2_-_zLa_0_._0_1_2#DELTA#_0_._0_0_6Ba_z(Zr_0_._5_5Ti_0_._4_5)O_3 (PLZT; z = 0-6 mol%) ceramic compositions were fabricated by a mixed-oxide method. X-ray diffraction studies of sintered ceramics indicate the coexistence of rhombohedral and tetragonal phases in the 5 mol% Ba-doped PLZT composition. Grain growth is inhibited with increasing Ba concentration in the PLZT system as evidenced by scanning electron micrographs. Dielectric constant and dielectric loss as a function of temperature suggest that #epsilon#_r_t and tan #delta# are increased up to compositions containing 4 and 5 mol% Ba, respectively. The dielectric maximum (#epsilon#_T_c) decreased to 4 mol% Ba and gradually increased to 6 mol% Ba, whereas, with increasing Ba concentration in the PLZT system, the Curie temperature (T_C) decreased from the composition with no Ba to that with 6 mol% Ba. Relaxor behavior as a function of temperature and frequency was ...
The electrochemical intercalation of non-solvated lithium in different graphited materials has been performed in LiClO{sub 4}-ethylene carbonate (EC) medium. The irreversible capacity observed during the first output is mainly due to the formation of a passivation layer made of electrolyte reduction products. These products have been characterized for different electrode reduction potentials using transmission electron microscopy (image, diffraction) and electron energy loss spectroscopy (EELS). EC reduction on the electrode surface in presence of LiClO{sub 4} leads to the formation of Li{sub 2}CO{sub 3} for potentials close to 0.8 V vs Li{sup +}/Li. For lower potentials, the electrolyte reduction reaction goes on with the formation of different lithium alkyl-carbonates. In LiClO{sub 4}-propylene carbonate (PC) medium, the interface phenomena are different. The reduction of a graphite electrode is characterized by the exfoliation phenomenon ...
The spent fuel management concept of direct ultimate disposal is compatible in its fundamental features with the law of the European Community. This applies to a national law prohibiting spent fuel reprocessing and the handling of plutonium in Germany, imposing restrictions on exporting spent fuel assemblies and importing plutonium and reprocessing remnants, and on power plant operators to employ reprocessing services abroad. Also, a nuclear power phase-out decided by the German government would in principle not mean a breach of the EURATOM treaty. (orig./HP) [Deutsch] Als Alternative zur geltenden Rechtslage werden im Deutschen Rundestag Aenderungen vorgeschlagen, die das Entsorgungskonzept der direkten Endlagerung - d.h. ein Verbot der Wiederaufarbeitung von Brennelementen aus deutschen Kernkraftwerken auch im europaeischen Ausland - vorschreiben und einen ``Ausstieg`` aus der Kernenergienutzung anordnen. Vor dem Hintergrund einer Analyse der tatsaechlichen Situation untersucht die ...
Candoxin (PDB #1JGK), a three-finger neurotoxin from Bungarus candidus venom, inhibits post-synaptic neuromuscular and neuronal alpha7nACh-receptors, and induces delayed cell-death throughout the glial population. When applied to cultured human glial cell lines, candoxin (CDX) induced cell death in a concentration (EC(50) approximately 1muM) and time dependent manner. Results of TUNEL-histochemistry further confirm CDX-induced brain (hippocampus, frontal cortex, and temporal regions) damage when administered intracerebroventricularly (i.c.v) in adult mice. In this study, we explored differential gene expression profiles following exposure of human glial (Hs 683) cell lines to CDX at various time intervals using Affymetrix-GeneChips. By means of MAS and GeneSpring analyses, 105 genes whose expression was significantly (P<0.01) altered by at least 3-fold were selected. Results of the genome analysis reveal that the potential role of CDX at ...
Partially purified UDPgalactosyltransferase (EC 2.4.1.22) from bovine milk has been used to synthesize millimolar amounts of compounds such as Gal..beta..(1..-->..4)Glc, Gal..beta..(1..-->..4)GlcNAc-..beta..-hexanolamine, and Gal..beta..(1..-->..4)-GlcNAc..beta..(1..-->..4)GlcNAc. The same method has been used to prepare similar compounds containing /sup 13/C-enriched galactopyranosyl moieties. Gal..beta..(1..-->..4)GlcNAc-..beta..-hexanolamine was also synthesized in a solid-phase system in which the GlcNAc-..beta..-hexanolamine glycoside was covalently linked to agarose beads. At pH 7.0 and at 1 to 5 mM Mn/sup 2 + +/ the yields of the galactosyl saccharides are greater than 90% by using 10% excess of UDPGal donor. The use of a 90% enriched (1-/sup 13/C)galactosyl residue allowed the determination of the most abundant conformer about the galactopyranosyl-glycoside linkage by analysis of the carbon-carbon coupling constants from Cl to Gal to the ...
The disposal of municipal solid waste in an environmentally sound manner is a major problem worldwide. The composting of the organic fraction of refuse transforms it into soil amendment that can be recycled on agricultural lands. In order to promote the use of compost among farmers, agronomic investigations have to evaluate the impact of its use on soil properties and plant growth. In a greenhouse experiment, a sample of locally produced compost was applied to a sandy clay soil at rates equivalent to 0, 25, 50, 100, and 200 t/ha with supplemental addition of NH_4 NO_3 at levels equivalent to 0, 25, 50 and 100 Kg N/ha. Barley (Hordium vulgare L.) and corn (Zea mays L. indentata) were grown as indicator crops and soil properties were determined over a period of 150 days. Plant growth was affected by N starvation until the compost was stabilized in the soil. Nitrogen starvation persisted for a longer period with increasing applications of compost. Supplemental addition of N hastened the ...
This paper describes total phenolics content and antioxidant activity in the ethanolic extract of leaves, bark and roots of five medicinal plants: Terminalia brasiliensis Camb., Terminalia fagifolia Mart. and Zucc., Copernicia cerifera (Miller) H.E. Moore, Cenostigma macrophyllum Tul. var. acuminata Teles Freire and Qualea grandiflora Mart. The total phenolics content of the plant extracts, determined by the Folin-Ciocalteu method, varied from 250.0 {+-}8,2 to 763,63 {+-}13.03 mg of gallic acid equivalent/g dry EtOH extract. The antioxidant activity of extracts was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay system. Extract of bark from T. brasiliensis, the most active, with an EC{sub 50} value of 27.59 {+-} 0.82 {mu}g/mL, was comparable to rutin (EC{sub 50} = 27.80 {+-} 1.38) and gallic acid (EC{sub 50} = 24.27 {+-} 0.31), used as positive controls. The relationship between total phenolic content and ...
Based on an multivariate statistical evaluation of binary and metric data relating to the soil cover of the European Community five regionally representative reference soils (EURO-Soils) have been identified for chemicals testing in the EC. The soil material sampled at representative localities in Italy, Greece, Great Britain, France and Germany was treated and prepared according to OECD Test Guideline 106 and analysed in detail. The homogenised specimens were subject to an EC-wide ring test to evaluate the feasibility of the modified guideline and to validate the physical-chemical amenability of the reference soils for sorption tests. The results proved the validity of the soils selected for assessing the potential behaviour of new chemicals in soil on the basis of a comparative evaluation of the individual test results obtained. In the light of this parametric assessment potential test soils were subsequently identified in the individual ...
Biofuels may contribute to both rural economic development and climate change mitigation and adaptation. The Gota Verde Project in Yoro, Honduras, attempts to demonstrate the technical and economic feasibility of small-scale biofuel production for local use by implementing a distinctive approach to feedstock production that encourages small farm sizes, mixed cropping of biofuel feedstock from Jatropha and food crops, particularly corn and beans, grown side by side on the same farmland and the total involvement of small rural farmers. But is the project sustainable? Using EC-Assess, the Earth Charter ethics-based assessment tool, to assess the sustainability of this project, the author found that in some assessment categories the actions surpassed the intended objectives, showing that the project was achieving certain Earth Charter goals without specifically stating its intention to address them. (Contains 3 images, 3 figures and 2 notes.)
In 2009, following approval of the European Marine Strategy Framework Directive (MSFD, 2008/56/EC), the European Commission (EC) created task groups to develop guidance for eleven quality descriptors that form the basis for evaluating ecosystem function. The objective was to provide European countries with practical guidelines for implementing the MSFD, and to produce a Commission Decision that encapsulated key points of the work in a legal framework. This paper presents a review of work carried out by the eutrophication task group, and reports our main findings to the scientific community. On the basis of an operational, management-oriented definition, we discuss the main methodologies that could be used for coastal and marine eutrophication assessment. Emphasis is placed on integrated ap...
It is well known that a protective film is formed on the graphite negative electrode in ethylene carbonate (EC) electrolyte solution. This film is lithium-ion conductive and protects the decomposition of the electrolyte solution. In the present paper, the electrode/electrolyte interfaces in lithium-ion rechargeable batteries were characterized by three-dimensional complex impedance plots, whose axes are real, imaginary parts and time. The film resistance R {sub sei} and charge transfer resistance R {sub ct} were determined for negative electrodes in EC/ethyl methyl carbonate (EMC) electrolyte solution, and the formation mechanisms of the interfacial film were discussed. Furthermore, the contributions of vinylene carbonate and ethylene sulfite, which are added into the electrolyte solution for the film formation, were investigated.
It is well known that a protective film is formed on the graphite negative electrode in ethylene carbonate (EC) electrolyte solution. This film is lithium-ion conductive and protects the decomposition of the electrolyte solution. In the present paper, the electrode/electrolyte interfaces in lithium-ion rechargeable batteries were characterized by three-dimensional complex impedance plots, whose axes are real, imaginary parts and time. The film resistance R _s_e_i and charge transfer resistance R _c_t were determined for negative electrodes in EC/ethyl methyl carbonate (EMC) electrolyte solution, and the formation mechanisms of the interfacial film were discussed. Furthermore, the contributions of vinylene carbonate and ethylene sulfite, which are added into the electrolyte solution for the film formation, were investigated.
In view of the persisting and understandable fear of parents with regard to radioactivity in the food of their babies as a consequence of the Chernobyl reactor accident, the Commission on Nutrition of the Deutsche Gesellschaft fuer Kinderheilkunde (German Society of Pediatrics) and the Strahlenschutzkommission have published a statement. According to this statement, the maximum permissible level of radioactivity in commercial baby food has been fixed by the EC to be 370 Bq/kg. The dietetic food industry itself has fixed a maximum for its products which is only a tenth of the radioactivity level permitted by the EC directive. The milk powders for infants tested since the reactor accident contained no measurable radioactivity or only very low amounts of Cs 134 or Cs 137, correspondung to a maximum of 25 Bq/kg in the product. Late damage to health is not to be expected. (orig./ECB).
The core-shell luminol-doped SiO2 nanoparticles were synthesized and immobilized on the surface of chitosan film coating graphite electrode by the self-assembled technique. Then, a novel electrogenerated chemiluminescence (ECL) sensor for pyrogallol was developed based on its ECL enhancing effect for the core-shell luminol-doped silica nanoparticles. The ECL analytical performances and the sensing mechanism of this ECL sensor for pyrogallol were investigated in detail. The corresponding results showed that: compared with the conventional ECL reaction procedures by luminol ECL reaction system, the electrochemical (EC) reaction of pyrogallol and its subsequent chemiluminescence (CL) reaction occurred in the different spatial region whilst offering a high efficiency to couple the EC with the ...
The Plant Life Assessment Network (PLAN) is a Brite Euram Type II Thematic Network, initiated by the European Commission to facilitate structured co-operation between all cost shared action projects already funded by the Commission which fall under this common technical theme. The projects involved address a multiplicity of problems associated with plant life assessment and are drawn from Brite-Euram, Standards, Measurement and Testing, Nuclear Fission Safety and Esprit EC programmes. The main aim of the Network is to initiate, maintain and monitor a fruitful co-operation process between completed, ongoing and future EC R and D projects, thereby promoting improved cross fertilization and enhanced industrial exploitation of R and D results. As the project is in its infancy, this presentation covers the background to the initiative in some detail. In particular two key aspects are highlighted, namely, the requirement of the ...
A two-step purification protocol was used in an attempt to separate the constitutive NAD(P)H-nitrate reductase [NAD(P)H-NR, pH 6.5; EC 1.6.6.2] activity from the nitric oxide and nitrogen dioxide (NO(x))...Full Text Available
An Ottawa-based company, ECS-Power Systems Inc., has successfully completed a series of tests on an innovative device called a hydrodynamic port (HDP), which makes it possible to automatically initiate and maintain emergency cooling of a nuclear reactor core by natural processes, without relying in any way on human intervention, instrumentation, electric power, valves or moving parts of any kind.
Several cDNA clones encoding Δ1-pyrroline-5-carboxylate reductase (P5CR, l-proline:NAD[P]+ 5-oxidoreductase, EC 1.5.1.2), which catalyzes the terminal step in...Full Text Available
The nucleotide sequence of the 5'-terminal oligonucleotides produced by pancreatic RNase digestion of bacteriophage T3 RNA polymerase (EC 2.7.7.6) transcripts of T3 DNA has been determined. The sequence...Full Text Available
A full-length complementary DNA clone encoding tryptophan decarboxylase (TDC; EC 4.1.1.28) from Catharanthus roseus (De Luca V, Marineau C, Brisson N [1989] Proc Natl Acad Sci USA 86:...Full Text Available
Acyl-CoA:diacylglycerol acyltransferase (EC 2.3.1.20) is a membrane protein present mainly in the endoplasmic reticulum. It catalyzes the final and committed step in the biosynthesis of triacylglycerol,...Full Text Available
Developments made under this program will play a key role in underpinning the technology for producing EC devices. It is anticipated that the work begun during this period will continue to improve materials properties, and drive yields up and costs down, increase durability and make manufacture simpler and more cost effective. It is hoped that this will contribute to a successful and profitable industry, which will help reduce energy consumption and improve comfort for building occupants worldwide. The first major task involved improvements to the materials used in the process. The improvements made as a result of the work done during this project have contributed to the enhanced performance, including dynamic range, uniformity and electrical characteristics. Another major objective of the project was to develop technology to improve yield, reduce cost, and facilitate manufacturing of EC products. Improvements directly attributable to the work ...
DescriptionAs part of a wider effort to develop new approaches to evaluating and quantifying the benefits of chemicals regulation, this project will review the effectiveness of existing information provision tools (such as classification and labelling for hazardous properties) in terms of affecting user behaviour. As some EC legislation relating to regulation of chemicals has been in place for some time, an assumption is made that the information provided by it is leading to an improvement in the way chem [continued...
The creation of a methodology about the Ecobalance of the main plastic materials manufactured in Europe is very helpful for many questions relating with these matters. This methodology is necessary for the EC and most of its members. It is important that these analysis have available, precise and up-to-date information. In order that these dates are well-known, the european industry of plastics recognised and started an ambitious project two years ago and now we can see the first results.
A 3.0-Å resolution electron density map of lobster glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) was computed. The essentially single isomorphous replacement map was very substantially...Full Text Available
Human serum dopamine-β-hydroxylase (3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase, EC 1.14.17.1) has been measured in a normal adult population by both enzymatic assay and by...Full Text Available
Summary Background Treatment of localised renal cell carcinoma consists of partial or radical nephrectomy. A substantial proportion of patients are at risk for recurrence because no effective adjuvant therapy exists. We investigated the use of an autologous, tumour-derived heat-shock protein (glycoprotein 96)-peptide complex (HSPPC-96; vitespen) as adjuvant treatment in patients at high risk of recurrence after resection of locally advanced renal cell carcinoma. Methods In this open-label trial, patients were randomly assigned to receive either vitespen (n=409) or observation alone (n=409) after nephrectomy. Randomisation was done in a one to one ratio by a computer-generated pseudo-random number generator, with a block size of four, and was stratified by performance score, lymph node stat...
The levels of General Transcription Factor (TF) IIA were examined during mammalian brain development and in rat embryo fibroblasts and transformed cell lines. The large TFIIA subunit paralogues ab and t are largely produced in unsynchronized cell lines, yet only TFIIA ab is observed in a number of differentiated tissue extracts. Steady-state protein levels of the TFIIA t, ab, and g subunits were significantly reduced when human embryonal (ec) and hepatic carcinoma cell lines were stimulated to differentiate with either all-trans-retinoic acid (ATRA) or sodium butyrate. ATRA-treated NT2-ec cells required replating to induce a neuronal phenotype and loss of detectable TFIIA t and g proteins. High levels of TFIIA t, ab, and g and Sp factors were identified in extracts from human fetal and rat...
Escherichia coli spheroplast protein y (EcSpy) is a small periplasmic protein that is homologous with CpxP, an inhibitor of the extracytoplasmic stress response. Stress conditions such as spheroplast formation induce the expression of Spy via the Cpx or the Bae two-component systems in E. coli, though the function of Spy is unknown. Here, we report the crystal structure of EcSpy, which reveals a long kinked hairpin-like structure of four ?-helices that form an antiparallel dimer. The dimer contains a curved oval shape with a highly positively charged concave surface that may function as a ligand binding site. Sequence analysis reveals that Spy is highly conserved over the Enterobacteriaceae family. Notably, three conserved regions that contain identical residues and two LTxxQ motifs are placed at the horizontal end of the dimer structure, stabilizing the overall fold. CpxP also contains the conserved sequence motifs and has a predicted ...
Germination inhibition of the marine macrophyte Phyllospora comosa was utilized as a sub-lethal end-point to assess and compare the effects of four oil dispersants and dispersed diesel fuel and crude oil combinations. Inhibition of germination by the water-soluble fraction of diesel fuel increased following the addition of each of the dispersants; the nominal 48-h EC{sub 50} concentration of diesel fuel declined from 6800 to approximately 400 {mu}l 1{sup -1} nominal for each dispersed combination. This contrasted with crude oil, where the addition of two dispersants resulted in an enhanced germination rate and an increase in nominal EC{sub 50} concentrations from 130 {mu}l 1{sup -1} for the undispersed crude to 4000 and 2500 {mu}l 1{sup -1}. The results indicate that, while germination inhibition of P. comosa may be enhanced by the chemical dispersal of oil response varies with type of both oil and oil dispersant. (author)
The author discusses the implementation in Germany of the EC Directive on Environmental Impact Statements in the light of the legal tradition and concepts of law in Germany, especially in the context of the nuclear licensing procedure. His analysis reveals some legal provisions and legal concepts in existing German law that will have to be ``sacrificed`` in order to do justice to the European Union, as in the formation of the body of EC law governing environmental issues, the Anglo-Saxon approach to regulatory law has been the prevailing line of orientation (the EU ecological audit being an example). On the whole, however, the implementation of the EU Directive will not lead to substantial changes beyond procedural modifications. (HP) [Deutsch] Der Autor diskutiert die Umsetzung der EG-Richtlinien in deutsche Rechtstraditionen und -vorstellungen, besonders beim atomrechtlichen Genehmigungsverfahren. Dabei seien Abstriche an deutsche ...
For an assessment of the future US spallation neutron source (SNS) target performance, radiation induced hardening and microstructural evolution were investigated as a function of ion dose for EC316LN stainless steel. Irradiation was carried out using 3.5 MeV Fe{sup +}, 360 keV He{sup +}, and 180 keV H{sup +} simultaneous ion-beams at 200 deg. C to simulate the damage, He and H production in the SNS target vessel wall. At low dose (< 1 dpa), the predominant defects were black dots whose number density saturated rapidly within a few dpa. This was followed by the evolution of interstitial loops whose number density saturated below 15 dpa. Although He-bubbles were not visible, severely scalloped loops suggested that the implanted He/H atoms existed in the form of small clusters. Comparison with reported neutron irradiation data showed that hardening and ductility loss occurred mostly in the black dot regime (< 1 dpa), but that good ductility (>20% ...
For an assessment of the future US spallation neutron source (SNS) target performance, radiation induced hardening and microstructural evolution were investigated as a function of ion dose for EC316LN stainless steel. Irradiation was carried out using 3.5 MeV Fe"+, 360 keV He"+, and 180 keV H"+ simultaneous ion-beams at 200 deg. C to simulate the damage, He and H production in the SNS target vessel wall. At low dose (< 1 dpa), the predominant defects were black dots whose number density saturated rapidly within a few dpa. This was followed by the evolution of interstitial loops whose number density saturated below 15 dpa. Although He-bubbles were not visible, severely scalloped loops suggested that the implanted He/H atoms existed in the form of small clusters. Comparison with reported neutron irradiation data showed that hardening and ductility loss occurred mostly in the black dot regime (< 1 dpa), but that good ductility (>20% elongation) was maintained ...
The KLL Auger electron spectrum of "8"8Sr generated in the EC-decay of "8"8Y has been analyzed at the instrumental resolution of 11 eV using a combined electrostatic spectrometer. Energies and relative intensities of the all nine transitions were determined and compared with theoretical predictions. Our value of 12067.3(12) eV measured for the absolute energy of the dominant KL_2L_3("1D_2) transition was found to be higher by 7.4 eV (i.e., more than 3#sigma#) than that one obtained in a measurement with external excitation. The discrepancy indicates substantial influence of the 'atomic structure effect' on absolute transition energies in our experiment. Very good agreement of the measured 0.14(3) and predicted 0.12 values for the KL_1L_2("3P_0/"1P_1) Auger transition intensity ratio clearly proved the predicted strong influence of the relativistic effects on the KL_1L_2("3P_0) transition rate even at Z = 38.
The impact of a mixture of oxytetracycline, chlortetracycline, tetracycline and doxycycline on Myriophyllum sibiricum and Lemna gibba was investigated using fifteen 12,000-L microcosms (k = 5, n = 3). Significant concentration-response relationships were only found for M. sibiricum, where dry mass was 69, 47, 30, and 7% of controls at respective treatment concentrations of 0.080, 0.218, 0.668, and 2.289 {mu}mol/L. Somatic endpoints were strongly and negatively correlated with percent light transmission, except plant length, which was positively correlated. Treated microcosms experienced a reduction in the percent of surface irradiance penetrating the water column as high as 99.8% at a depth of 70 cm, relative to controls. Position relative to the water column was likely responsible for the differential effects observed between floating (L. gibba) and submerged (M. sibiricum) species of macrophytes. A hazard quotient assessment of the lowest EC{sub 10} value ...
The Joint Work Session of the ITER CDA (Conceptual Design Activities) by four parties, (eg. Japan, USA, USSR and EC), which has continued during 3 years from May 1988 to December 1990 was completed successfully. During the CDA, overall diagnostic systems for the next generation machine was performed for the first time and the principal tasks of Diagnostic research and development (R and D) are identified. In this paper, radiation hardening problems, which should be solved for the period 1991 through 1996 of the ITER EDA (Engineering Design Activities), are described. (author).
The removal of Reactive Black 5 dye in an aqueous solution by electrocoagulation (EC) as well as addition of flocculant was investigated. The effect of operational parameters, i.e. current density, treatment time, solution conductivity and polymer dosage, was investigated. Two models, namely the artificial neural network (ANN) and the response surface method (RSM), were used to model the effect of independent variables on percentage of dye removal. The findings of this work showed that current density, treatment time and dosage of polymer had the most significant effect on percentage of dye removal (p0.8). PMID:21411950
Intensities of {gamma}-transitions emerging from the EC decay of {sup 203}Pb were measured precisely. The obtained relative {gamma}-intensities are 100%(279.2keV), 4.14+-0.08%(401.3keV) and 0.932+-0.022%(680.5keV). The 279.2 and 680.5keV level feeding {beta}-branching ratios were deduced to be 95.3+-0.1 and 4.7+-0.1% respectively. {sup 203}Pb is suggested for calibration purposes. (author).
The purpose of this work is to characterize the role of the financial institutions in achieving sustainable development meaning a process of development which leaves at least the same amount of capital, natural and man-made, to future generations as current generations have access to. This makes it clear that sustainable development is about capital allocation and thus should be at the core of financial markets activity. On a more practical level the different ways banks affect environment are analyzed: as investors - supplying the investments with environmental perspective; as lenders - developing new financial products to encourage sustainable development; as valuers - estimating risks and opportunities in project-financing; as powerful stake holders - as shareholders and lenders they can exercise considerable influence over companies; - as polluters - while not dirty industries, financial institutions do consume natural resources. By the study of these ...
Background and purpose: We evaluate the feasibility of concomitant and adjuvant docetaxel combined with three-dimensional conformal radiotherapy (3D-CRT) and androgen deprivation in high-risk prostate carcinomas. Methods: Fifty men with high-risk localized prostate cancer (16), locally advanced (28) or very high-risk prostate cancer (6) were included. Seventy Gy were delivered on prostate and seminal vesicles in 35 fractions, concurrently with weekly docetaxel (20 mg/m"2). Three weeks after the completion of 3D-CRT, docetaxel was given for 3 cycles (60 mg/m"2), every 3 weeks. Patients had to receive LHRH agonist during 3 years. Results: The intent to treat analysis shows that four patients out of 15 stopped prematurely the chemotherapy due to grade 3-4 acute toxicity. In the per protocol analysis, 46 patients completed a full-dose chemoradiation regimen representing 413 cycles: five patients experienced a grade 3 toxicity, and 15 patients experienced a grade 2 toxicity. With a median ...
Experiments were conducted in controlled growth chambers to evaluate how increase in CO{sub 2} concentration affected sucrose metabolizing enzymes, especially sucrose phosphate synthase (SPS; EC 2.4.1.14) and sucrose synthase (SS; EC 2.4.1.13), as well as carbon metabolism and partitioning in a tropical epiphytic orchid species (Oncidium goldiana). Response of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco; EC 4.1.1.39) to elevated CO{sub 2} was determined along with dry mass production, photosynthesis rate, chlorophyll content, total nitrogen and total soluble protein content. After 60 days of growth, there was a 80% and 150% increase in dry mass production in plants grown at 750 and 1100 {mu} l{sup -}1 CO{sub 2}, respectively, compared with those grown at ambient CO{sub 2} (about 370 {mu} l{sup -}1). A similar increase in photosynthesis rate was detected throughout the growth period when measured under growth ...
Iron deficiency (ID) is associated with increased levels of norepinephrine (NE) in plasma and urine. They investigated the effect of 5-7 days exposure to three different environmental temperatures (10/sup 0/C, 24/sup 0/C, 30/sup 0/C) on urinary catecholamine levels to test the hypothesis that increased thermogenic activity is causal to this increased excretion in iron deficiency. Catecholamines were analyzed from acidified urine by HPLC-EC. The mean Hb in ID animals was 3.1 +/- .5 versus controls of 12.8 +/- 9. These data demonstrate that contrary to previous reports NE excretion is not normalized at a thermoneutral temperature and suggests a basic abnormality in peripheral SNS activity and NE metabolism in iron deficiency that is independent of environmental drive from thermogenesis.
The primary UK legislation relating to the use of radioactive materials are the Radioactive Substances Act 1993 (RSA, 1993) and the Ionising Radiations Regulations 1999 (IRR, 1999). These implement the European Union's Basic Safety Standards Directive (EUBSS) (EC, 1996). The Radioactive Substances Act 1993 (RSA93) regulates the accumulation, storage and disposal of radioactive waste, principally to control potential doses to members of the public. The Ionising Radiations Regulations 1999 (IRR, 1999) deal primarily with regulating the doses that people receive at work. Both of these pieces of legislation apply to the use of materials containing naturally occurring radionuclides. Historically UK regulations relating to radioactive materials have covered both artificial and natural radionuclides
The type III secretion system among Gram-negative bacteria is known to deliver effectors into host cell to interfere with host cellular processes. The type III secretion system in Yersina, Pseudomonas and Enterohemorrhagic Escherichia coli have been well documented to be involved in the bacterial pathogenicity. The existence of type III secretion system has been demonstrated in neuropathogenic E. coli K1 strains. Here, it is observed that the deletion mutant of type III secretion system in E. coli strain EC10 exhibited defects in the invasion and intracellular survival in Acanthamoeba castellanii (a keratitis isolate) compared to its parent strain. Next, it was determined whether type III secretion system plays a role in E. coli K1 survival inside Acanthamoeba during the encystment process...
This paper describes the simulation of the operating environment of the New York Power Pool (NYPP) within the Dispatcher Training Simulator facility at the New York State Electric and Gas Corporation (NYSEG). The NYSEG control center uses real-time data received from the NYPP control center to control its internal generation. In addition, the NYSEG dispatchers work very closely with the NYPP dispatchers. The exact emulation of the Generation Control functions of the NYPP EMS, and the associated data exchange with the NYSEG ECS, contribute greatly to the high degree of realism achieved in the NYSEG DTS facility. The accuracy of the power system simulation in the DTS has been validated against actual power system disturbances recorded at NYSEG.
Bismuth radioisotopes, produced by 50-MeV proton bombardment of a lead target in a cyclotron, are separated from the lead target material by ion-exchange chromatography on a column containing 5.0 ml of Chelex 100. After a decay period of 24 hr, the /sup 203/Pb formed in situ is eluted from the column and then separated from /sup 200/Tl and /sup 201/Tl on a second ion-exchange column containing 0.5 ml of Chelex 100. Separations are sharp and carrier-free /sup 203/Pb is obtained.
The incorporation of additives designed to sacrificially react on the surface of cathode materials of lithium ion batteries has been investigated. Addition of low concentrations of inorganic additives including lithium bisoxalatoborate (LiBOB), lithium difluorooxalatoborate (LiBF{sub 2}(C{sub 2}O{sub 4})), and tetramethoxy titanium (TMTi) to 1 M LiPF{sub 6} in 1:1:1 EC/DEC/DMC improves the capacity retention of Li/Li{sub 1.17}Mn{sub 0.58}Ni{sub 0.25}O{sub 2} cells cycled to 4.9 V vs. Li. Surface analysis of the cathode materials (XPS and IR) suggests that structure of the cathode surface film is modified by the presence of the additives resulting in a decrease in detrimental electrolyte oxidation reactions on the cathode surface. (author)
The function of selenium in an organism is mediated mostly by selenoproteins including glutathione peroxidase. Glutathione peroxidase is a potent anti-oxidative enzyme, scavenging a variety of peroxides. The green alga Scenedesmus quadricauda was used to investigate the relationship between the toxicity of selenium and the glutathione peroxidase activity. Selenium resistant strains SeIV and SeVI were synchronized and grown in high concentrations of Se (selenite or selenate). As a measure of selenium toxicity the EC50 values were determined. During growth of the untreated wild type, glutathione peroxidase activity increased slightly and then declined gradually until the end of the cell cycle. A similar pattern was observed in untreated resistant strains and when resistant strains were grown...
Certain fluorocarbons, such as difluorodichloromethane (FC 12), depress the cardiovascular system by diminution of all the transmembrane ionic conductances in cardiac tissues. Does FC 12 also inhibit active transport and thus enzymatic activity and cellular energy. We measured phosphocreatine (PC), adenosine triphosphate (ATP) and cyclic adenosine monophosphate (AMPc) in rat hearts. Rats were randomly divided into 4 groups; 2 control groups: one breathing a mixture of oxygen (21%) and nitrogen (79%) (group C) and the other breathing the same mixture but simultaneously perfused with 1 microgram/kg/min. epinephrine (groupe E-C); 2 trial groups T and E-T where nitrogen was replaced by FC 12. The maximal FC 12 concentration of 720 micrograms/ml in arterial blood produced no significant difference in the concentrations of these three metabolites compared with controls.
We determined the chromosomal localization and structure of the gene encoding human type II inosine 5{prime}-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205), an enzyme associated with cellular proliferation, malignant transformation, and differentiation. Using polymerase chain reaction (PCR) primers specific for type II IMPDH, we screened a panel of human-Chinese hamster cell somatic hybrids and a separate deletion panel of chromosome 3 hybrids and localized the gene to 3p21.1{yields}p24.2. Two overlapping yeast artificial chromosome clones containing the full gene for type II IMPDH were isolated and a physical map of 117 kb of human genomic DNA in this region of chromosome 3 was constructed. The gene for type II IMPDH was localized and oriented on this map and found to span no more than 12.5 kb.
Determination of the radiocarbon (14C) content of airborne particulate matter yields insight into the proportion of the carbonaceous material derived from fossil and contemporary carbon sources. Daily samples of PM2.5 were collected by high-volume sampler at an urban background site in Birmingham, UK, and the fraction of 14C in both the total carbon, and in the organic and elemental carbon fractions, determined by two-stage combustion to CO2, graphitisation and quantification by accelerator mass spectrometry. OC and EC content was also determined by Sunset Analyzer. The mean fraction contemporary TC in the PM2.5 samples was 0.50 (range 0.27-0.66, n=26). There was no seasonality to the data, but there was a positive trend between fraction contemporary TC and magnitude of SOC/TC ratio and fo...
Soya- and oats-lipoxygenase (E.C. 1.13.1.13) are incubated by "1"4C-marked linoleic acid. The volatile aldehydes arising thereby are isolated. The activity of the components separated by gaschromatography is written down by a printing indicator and the impulses/min are registered and printed out by a ratemeter. Thus the aldehydes which are produced by the enzymatic oxydation with lipoxygenase from the molecule of the linoleic acid can be determined. The composition of the mixture of aldehydes is calculated in mol-% from the measured impulses for peak. A possible origin of pathway is indicated for the main reaction products hexanal (soyalipoxygenase) and non-trans-2-enal (oats-lipoxygenase). (orig.).
A new microbial transglutaminase (MTGase or MTG, EC 2.3.2.13) from a Streptomyces sp. strain isolated from Brazilian soil samples was characterized in crude and purified forms. The aim of this work is to provide relevant information about a new transglutaminase and to compare its characteristics with the well-known commercial transglutaminase from Ajinomoto Co. Inc. (Activa? TG-BP). The enzyme from Streptomyces sp., in both crude and pure forms, exhibited optimal activity in the 6.0?6.5 pH range and at 35?40?C. The results for the commercial enzyme were the same. A second maximum of activity was observed at pH?10.0 with both the crude Streptomyces sp. enzyme and the commercial enzyme. This interesting fact has not been reported in the literature previously. The fact that this second maximu...
According to the calculations, intensity of the KL_1L_2("3P_0) Auger transition should drastically increase with increasing atomic number Z due to the relativistic effects. However, this behavior was experimentally proved only for very few elements. A lack of enough precise experimental data in the atomic number region Z<45 does not enable one to distinguish between relativistic and non-relativistic approaches in this region. Thus for Z=38 the KL_1L_2("3P_0/"1P_1) intensity ratio was determined with relative uncertainty of 63 % in the only measurement with external excitation. Here we present results of our investigation of the KLL Auger electron spectrum of "8"8Sr generated in the EC decay of "8"8Y (T_1_/_2= 106.6 d). Electron spectra were measured with the 11 eV instrumental resolution using a combined electrostatic spectrometer. The present value of the KL_2L_3("1D_2) absolute transition energy in Sr is higher by 7.4 eV (i.e. more than 3#sigma#) then that ...
Two methods, a traditional emulsion technique and a high voltage electrostatically modified encapsulation system, were used to fabricate degradable chitosan/beta -tricalcium phosphate (beta-TCP) microspheres. The two distinct kinds of microspheres both exhibited good sphericity and the beta-TCP was trapped well inside the chitosan gel. The microspheres prepared by high voltage electrostatic system exhibited a rougher outer surface and narrower size distribution. These microspheres were then used as an added constituent to commercially available PMMA bone cement. Four modified cement composites that were prepared with different composition ratios of the two kinds of chitosan/beta-TCP microspheres that were made from emulsion technique (C1P1 and C2P1) and from a process by a high voltage electrostatic system (EC1P1 and EC2P1) were compared with the PMMA cement (Pure P). The characteristics of these materials indicate that with the addition of ...
This guide is one of the actions following from the recommendations of the Thermie B project that aimed to support the development of a new European Integrated Clean Coal (CCT) Program concept (STR - 1121 - 96), November 1998. The concept aimed to enhance the market deployment of EU CCTs. This guide is prepared for EU industry to help them finding support for their CCT exports to the target markets. The guide will include easy accessible information on the most relevant EC-programs and is intended as a practical tool for EU CCT industry, to assist them in identifying and selecting the export support and programs best able to support their specific export assistance. The guide is a manual (signpost) through the 'jungle of assistance' and therefore does not include extensive information on application procedures, since this kind of information can be easily obtained, once the relevant program is identified. Also information will be presented on EU ...
Abstract in english Extracts of nine species of plants traditionally used in Colombia for the treatment of a variety of diseases were tested in vitro for their potential antitumor (cytotoxicity) and antiherpetic activity. MTT (Tetrazolium blue) and Neutral Red colorimetric assays were used to evaluate the reduction of viability of cell cultures in presence and absence of the extracts. MTT was also used to evaluate the effects of the extracts on the lytic activity of herpes simplex virus type (more) 2 (HSV-2). The 50% cytotoxic concentration (CC50) and the 50% inhibitory concentration of the viral effect (EC50) for each extract were calculated by linear regression analysis. Extracts from Annona muricata, A. cherimolia and Rollinia membranacea, known for their cytotoxicity were used as positive controls. Likewise, acyclovir and heparin were used as positive controls of antiherpetic activity. Methanolic extract from Annona sp. on HEp-2 cells presented a CC50 value at ...
The University of Groningen (RUG) has developed an expert system on cleaning of biomass producer gas. This work was carried out in close co-operation with the Biomass Technology Group B.V. (BTG) in Enschede, The Netherlands within the framework of the EC supported JOR3-CT95-0084 project. The expert system was developed as a tool for the designer-engineer of downstream gas cleaning equipment and consists of an information package and a flowsheet package. The packages are integrated in a client/server system. The flowsheeting package of the expert system has been designed for the evaluation of different gas cleaning methods. The system contains a number of possible gas cleaning devices such as: cyclone, fabric filter, ceramic filter, venturi scrubber and catalytic cracker. The user can select up to five cleaning steps in an arbitrary order for his specific gas cleaning problem. After specification of the required design parameters, the system calculates the main ...
The authors introduce the single electron (Cooper-pair) tunneling junctions using c-axis Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+d} (Bi-2212) superconducting single crystal whiskers. Focused-ion-beam (FIB) etching patterned the Bi-2212 whiskers. The fabricated small stacked junctions have in-plane area S smaller than <1 {micro}m{sup 2}. The junctions showed the current-voltage (I-V) characteristics with the periodic structure of current peaks. The stacking layered structure of Bi-2212 works as multi-junctions array which decrease the effective capacitance, C{sub {Sigma}} = C{sub 0}/N, where C{sub 0} is the capacitance of junction and N is the layer number of elementary junctions. The period of current peaks of I-V curves corresponds to the charging energy of the single Cooper pair, 2Ec (=e{sup 2}/C{sub {Sigma}}).
The meeting was arranged into the following sessions: introductory; advanced ceramics and ceramic composites; ceramic and metal matrix composites; electronic materials and devices; acoustoelasticity, stress, and texture; composites-porosity, strength, and UT propagation; process modeling and monitoring; thermal wave physics; material properties, composites, surfaces, and interfaces; acoustic emission; ferromagnetic materials; new sensors; NDE reliability assessment; elastic wave scattering and propagation; image analysis, data storage, and signal processing; UT transducers; weldments and bonded materials; eddy current models; unified life cycle engineering; x rays, CT, and NMR; eddy current probes and instruments; acoustic microscopy imaging, and reconstruction; signal processing, measurement techniques, and systems; NDE applications of artificial intelligence; crack behavior influenced by history; inversion procedures for UT and EC; process control and material ...
Nuclear energy related research in Switzerland is concentrated at PSI`s Nuclear Energy and Safety Research Department (NES). The total effort invested in nuclear energy research in 1998 amounted to about 195 py/a and 4.5 millions CHF of investment and maintenance costs. Approximately half of the salary, investment and maintenance costs are externally funded, primarily by the Swiss Utilities, the national co-operative for the disposal of nuclear waste (NAGRA), the Federal Office of Energy (BFE) through the nuclear safety inspectorate (HSK) and the Federal Office for Science and Education (BBW) in connection with the EC Framework Programmes; an increasing part of external funding is coming from domestic and foreign industry (nuclear component and fuel suppliers). The activities of the department are concentrated on three main domains of: Safety and related problems of operating plants; safety features of future reactor and fuel cycles; waste management. 4 % of the ...
64Cu (T1/2=12.7h, ?- decay: 40%, ?+ decay: 19%, E.C. decay: 41%) is one of the most useful radioisotope in the nuclear medicine due to its multiple decay mode and the intermediate half-life. Several nuclear reaction, i.e., 64Ni(p,n)64Cu, 68Zn(p,?n)64Cu and 64Ni(d,2n)64Cu have been investigated for production. The highest could be obtained with proton irradiation on the enriched 64Ni target. For mass and routine production, the 64Ni target fabrication using electroplating, the reliable chemical separation of 64Cu from the irradiated 64Ni target and the effective recovery process for the recycling of very expensive enriched material ($20,000/g) and so forth are absolutely necessary to be established. In this work, we report our mass production method of 64Cu with 64Ni and Cyclone-30 accelerator
The effect of chronic administration of phenobarbital on the binding of phorbol-12,13-dibutyrate (({sup 3}H)PDBu), an activator of protein kinase C (PKC), was examined in rat liver microsomes. A significant increase in the number of binding sites was observed in microsomes of Fisher 344 rats. However, no change appeared in liver cytosol binding of PDBu. Consequently, a translocation process of PKC is unlikely. The increase in ({sup 3}H)PDBu binding in liver microsomes is significant 24 h. after one injection of phenobarbital and reaches its maximum in 2 days. In other strains of rats (ACI and lean Zucker), significant differences were found in the increase of ({sup 3}H)PDBu binding in microsomes. Fisher 344 were the most sensitive, lean Zucker rats, the least sensitive. Those results parallel the pentoxy-resorufin O demethylase activity in the microsomes of the same animals. EC{sub 50} values for inhibition of ({sup 3}H)PDBu binding by pentobarbital were determined ...
Steam Generator (SG) tubes in PWR plant are periodically inspected using eddy current testing (ECT) method. In Japan, bobbin coil type dual function probe is used for full length inspection, but the detectability for circumferential crack is very poor, and to improve detectability for circumferential crack and supplement regular ECT, various kinds of multi segment eddy current probes and multi transducer ultrasonic testing (UT) method have been developed. ECT probes are constructed of multiple surfaceriding special winding differential type coils and UT probe consists of 16 transducers which are spaced equally around the probe circumference for 360deg wall coverage. Both of those EC and UT probes are designed effective to detect circumferential crack. On the other hand, various kinds of laboratory induced circumferential cracks have been made and destroyed to prove the detectability of these probes. (author).
In most countries, residential electricity consumption typically ranges from 20% to 40% of total electricity consumption. This energy is used for heating, cooling, refrigeration and other end-uses. Significant energy savings are possible if new appliance purchases are for models with higher efficiency than that of existing models. There are several ways to ensure or encourage such an outcome, for example, appliance rebates, innovative procurement, and minimum efficiency standards. This paper focuses on the latter approach. At the present time, the US is the only country with comprehensive appliance energy efficiency standards. However, many other countries, such as Australia, Canada, the European Community (EC), Japan and Korea, are considering enacting standards. The greatest potential impact of minimum efficiency standards for appliances is in the developing countries (e.g., China and India), where saturations of household appliances are relatively low but ...
Liquid-liquid extractive separation of lithium isotopes was carried out in order to investigate the fluctuation of separation factors (a) as a function of salt concentrations in an aqueous phase. Two equations for separation factor (a_o_b_s) as a function of the concentration were introduced; one for the diluted region, and another for the concentrated region. In the former solution where hydrated lithium ions are predominant, 1n a_o_b_s = Ac + B, and in the latter where ion-pairs with anions are predominant, 1n a_o_b_s = Dc + E(c - F)"1"/"3 + G. Some guidelines are derived from the salt-specific constants A, B, D, E, F and G. The heavier isotopes are inclined to be in the more hydrated state in the diluted solution, while the lighter isotopes tend to be in a less hydrated state. In the concentrated solution, heavier isotopes are more likely to be in ion-pair form. Ionic association occurs from the lower concentration in the order of LiI < LiBr < LiCl. The ...
Low expression of osmotically responsive genes 2 (LOS2) encodes an enolase (2-phospho-D-glycerate hydrolase, EC 4.2.1.11) that converts 2-phospho-D-glycerate (PGA) to phosphoenolpyruvate (PEP) in the glycolytic pathway in Arabidopsis. Meanwhile, it is a transcriptional activator of cold-responsive gene, negatively controlling the expression of STZ/ZAT10, a zinc finger transcriptional repressor of cold-responsive gene from Arabidopsis. A novel LOS2 gene, designated PtrLOS2 (GenBank accession number GQ144341), was isolated from trifoliate orange [Poncirus trifoliata (L.) Raf.]. The PtrLOS2 cDNA is 1 662 bp in length with a 1 338 bp open reading frame (ORF), encoding a deduced 445 amino acid residue protein with a predicted molecular mass of 47.79 kDa and an isoelectric point of 5.54. The ded...
An electrolyte for high voltage lithium metal anode cells must simultaneously satisfy at least the following requirements; (i) high cycling efficiency on the lithium metal anode; (ii) higher oxidation potential than the charging voltage, and (iii) high specific conductivity. We have examined various electrolytes for lithium metal anode cells using a high voltage cathode, LiMn{sub 1.9}Co{sub 0.1}O{sub 4}. Of the electrolytes resistant to high voltage that we used, a system containing 60 to 90 vol.% of dimethyl carbonate (DMC) mixed with ethylene carbonate (EC) and 1.0 M lithium hexafluorophosphate (LiPF{sub 6}) provided the best cycling efficiency on a lithium metal anode, as well as a high specific conductivity around 10 mS cm{sup -1} at 20 C. (orig.)
Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) is the first enzyme in the biosynthetic pathway of the branched-chain amino acids. It catalyzes the conversion of two molecules of pyruvate into 2-acetolactate or one molecule of pyruvate and one molecule of 2-ketobutyrate into 2-aceto-2-hydroxybutyrate. AHAS requires the cofactors thiamine diphosphate (ThDP), Mg{sup 2+} and FAD for activity. The herbicides that target this enzyme are effective in protecting a broad range of crops from weed species. However, resistance in the field is now a serious problem worldwide. To address this, two new sulfonylureas, monosulfuron and monosulfuron ester, have been developed as commercial herbicides in China. These molecules differ from the traditional sulfonylureas in that the heterocyclic ring attached to the nitrogen atom of the sulfonylurea bridge is monosubstituted rather than disubstituted. The structures of these compounds in complex with the catalytic subunit of Arabidopsis ...
Since 1992, the fruitful collaboration of the Russian and Western-European technical support organizations (TSOs) is being continued due to the support of the European Commission. There are two main areas of activities. The first one is more of methodological assistance and enhancing RF TSOs capabilities to support Rostekhnadzor decision making process. Experience and knowledge acquired in this area projects increase RF TSOs capabilities regarding a wide spectrum of safety related issues assessment, in particular safety analyses, reactor vessel embrittlement, application of 'leak before break' concept, severe accident and accident management, fire risk evaluation, etc. The second area is focused on licensing related assessments of EC financed on site assistance projects (modernisations). This area projects promote implementation in Russia a licensing process based on a technical dialogue between operator and regulator as well contributes to transfer of Western ...
The SPring-8 linac has been improved to realize stable top-up injection into the SPring-8 and the NewSUBARU storage rings. The beam energy instability of 0.02% rms in the long term was achieved by means of reducing RF variations, providing beam energy compensation, reinforcement of monitor systems and introduction of beam feedback controls: Variations in the RF power and phase have been reduced by improving the voltage regulation system for the klystron modulator, and by stabilizing the temperature drift of the atmosphere and cooling water in order to reduce the phase variation. A new synchronous oscillator synchronizes a beam trigger pulse and a 2856 MHz reference signal, reducing variation in the beam charge. A beam energy compression system (ECS) was installed to compensate for accidental energy variation and reduce the energy spread. Beam feedback controls compensate for residual long-term variations of beam trajectory and energy. (author)
Embryos of chicken (Gallus domesticus), domestic duck (Anas platyrhynchos), and common eider duck (Somateria mollissima) were exposed in ovo to PCBs and to polycyclic aromatic hydrocarbons. Two coplanar PCBs, 3,3{prime},4,4{prime}-tetrachlorobiphenyl (PCB {number_sign}77) and 3,3{prime},4,4{prime},5-pentachlorobiphenyl (PCB {number_sign}126), were considerably more lethal and potent as inducers of 7-ethoxyresorufin O-deethylase (EROD) in chicken embryos (Gallus domesticus) than in embryos of the other two species. In chicken embryos, these compounds caused edema and eye and beak deformities. An artificial mixture of 18 PAHs which all have been detected in environmental samples, was slightly more toxic to embryos of the domestic duck and the common eider duck than to chicken embryos. The most potent compound in the mixture was benzo(k)fluoranthene. When chicken embryo livers were exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vitro, EROD was induced by very low concentrations ...
Airbag pressure vessels for the north-American market mainly are made by forging and by the use of steel alloys. In Europe aluminum alloys are common and the manufacturing process is extrusion of circular blanks - made from cold rolled plates - in a form applying a 100 t press at room temperature. Then by heat treatment the strength/hardness of the material is properly adjusted and after that the pressure vessel parts have to be continuously inspected with an inspection and handling cycle time of 3 s. Inspection of the axis-symmetric parts is asked for surface breaking extrusion defects as well as for surface parallel delaminations in the bulk volume. Furthermore, the material strength is a quality characteristic that has to be nondestructively registered and documented. The inspection is performed by eddy current probes and an EMAT, of which the eddy current impedance measurements are used for surface breaking extrusion defect detection and sizing (single frequency technique with ...
Energy conservative building design has triggered greater interests in developing flexible and sophisticated air conditioning systems capable of achieving enhanced energy-savings potential without sacrificing the desired thermal comfort and indoor air quality (IAQ). This research work greatly aimed at achieving enhanced energy conservation, good thermal comfort and better IAQ for space conditioning with the application of combined variable refrigerant volume (VRV) and variable air volume (VAV) air conditioning (A/C) systems. Experimental investigation on the proposed combined air conditioning system with the application of intelligent fuzzy logic controller was performed for summer and winter climatic conditions to substantiate the energy-savings capability. The proposed system experimentally analyzed under fixed ventilation, demand controlled ventilation (DCV) and combined DCV and economizer cycle (EC) ventilation techniques effectively conserved 44% and 63% of ...
A number of test series to investigate passive safety systems for the next generation of Light Water Reactors have been performed in the PANDA multi-purpose facility at the Paul Scherrer Institut (PSI). The large scale thermal-hydraulic test facility allows to investigate LWR containment phenomena and system behaviour. PANDA was first used to examine the Passive Containment Cooling System (PCCS) for the Simplified Boiling Water Reactor (SBWR). In 1996 new test series were initiated; all related to projects of the EC Fourth Framework Programme on Nuclear Fission Safety. One of these projects (TEPSS) is focused on the European Simplified Boiling Water Reactor (ESBWR). The ESBWR containment features and PCCS long-term post LOCA response were investigated in PANDA. The PCCS start-up was demonstrated, the effect of nitrogen hidden somewhere in the drywell and released later in the transient was simulated and the effect of light gases (helium) on the PCCS performance was ...
One of the Eddy Current Testing issues in aeronautics is the inspection of fastened structures to detect flaws nearby rivets which can grow because of mechanical stress. EADS and the CEA LIST have started a collaborative work with the support of the Ile-de-France Region to develop a simulation tool of EC fastened structures testing, integrated to the CIVA platform, aimed at conceiving testing methods, optimizing and qualifying it. The volume integral method using the Green dyadics formalism has been chosen in order to get a fast resolution of Maxwell equations. A first milestone was to build a simulation model of multilayer structures testing, thanks to the use of the multilayer Green dyads. Because of the rivet volume, 60 times bigger than the one of a typical flaw, a large number of discretization cells are needed. Therefore an iterative method has been developed in order to numerically solve large calculation zones. Finally, the flaw response simulation mostly ...
Chemicals under the trade names Nalco 537-DA, Nalco 625, Nalco 7607, Nalco 5165, Ivamin, and technical monoethanolamine are used extensively in the oil refinery industry. Aquatic toxicity tests were conducted using zebra fish fry (Brachydanio rerio) and the unicellular algae Isochrysis galbana (a flagellate) and Chaetoceros gracilis (a diatom). Inhibition of cell division, chlorophyll content, and "1"4CO_2 uptake in the algae were sensitive end points. The effective concentrations (EC50s) of growth inhibition were 0.1 mg/L (Ivamin; I. galbana), 0.8 mg/L (Nalco 7607; I. galbana), 6 mg/L (Nalco 625; I. galbana), 10 mg/L (Nalco 5165; C. gracilis), and 15 mg/L (Nalco 537-DA; C. gracilis). The lethal concentrations (LC50s) (96 h) toward zebra fish fry was 1 mg/L for Nalco 7607, 6.5 mg/L for Nalco 537-DA, 7.1 mg/L for Nalco 625, and 20 mg/L for Ivamin 803. Monoethanolamine had an LC50 higher than 5,000 mg/L. Nalco 5165 was not tested on fish fry. The heartbeat frequency ...
Many of today's automated real-time testing systems for embedded systems were developed using expensive custom hardware and software. In this article they describe how to use commercially available off-the-shelf hardware and software to design and develop an automated real-time test systems for Embedded Programmable Logic Controller (PLC) Based Control Systems. The system development began with the implementation of the VALI/TEST Pro testing methodology as a means for structuring the testing. Using this methodology, they were able to decompose system requirement documents for a Personnel Safety System (PSS) into its high, intermediate and detail level requirements. next, the validation procedures for the PSS system were decomposed into testing units called builds, test runs and test cases. To measure the PSS system's test coverage three levels of system requirements were mapped to their respective unit level of test using a specially constructed validation matrix that ...
The aim of this work is to provide a comprehensive and consistent description of the complexity of laws regulating the field of biotechnology, mainly focusing on the definition of items to be patented, which is one of the most important and also controversial issues within the new 98/44/EC set of rules. As biotechnology is a specialist and multidisciplinary field, it has begun by giving a general description of the field, outlining the grounds for the new rules, and then thoroughly examined and evaluated previous national and international laws especially with regard to patenting. This was followed by an evaluation of what can be patented according to the new instructions by systematically assessing the section defining items to be patented in the field of biotechnology. It is used to be a matter of opinion whether biotechnological material was to be considered a discovery or an invention, the former being impatentable according to patenting laws. The new law pays ...
This report describes recent extensions to the energy-systems GMM (Global Multiregional MARKAL) model undertaken by the Energy Economics Group (EEG) of the Paul Scherrer Institute (PSI) in Switzerland (hereon referred to as PSI-EEG) in the context of the SAPIENTIA project sponsored by the European Commission (DG Research) and the Swiss National Centre for Competence in Research on Climate (NCCR-Climate). GMM is a multi-regional 'bottom-up' energy-systems optimization model that endogenizes technology learning. The model has been developed and is used at PSI-EEG. The main extensions undertaken here concern the incorporation of a clusters approach to technology learning, the introduction of an improved representation of the transportation sector with emphasis on the passenger sub-sector and the implementation of marginal abatement curves for CH4 and N2O, two main non-CO2 greenhouse gases. Also, a linear representation of the atmospheric concentration of CO2, CH4 and N2O has been ...
The basis of assessment for particulate exhaust emissions is the gravimetric analysis of the particle concentration of diluted exhaust gases at temperatures below 52 C. This is very time consuming and takes sufficient sensitivity at low particulate emission rates like downstream of particle filters. For this reason the C/S-method, based on the thermographic analysis of carbon and sulfur, has been developed as an alternative to the gravimetric anallysis. This method yields particle mass as well as the main particle compounds. Comparisons between both methods have been carried out for heavy duty and automobile diesel engines as well as road vehicles and large diesel engines. The tests were conducted with commercial diesel fuel and also with other fuels, such as heavy oils. It could be shown that the C/S-procedure yields the same results as the gravimetric procedure independent of engine, engine mode and kind of fuel. The analysis of all important particulate compounds - elemental carbon ...
The experimental effect investigation programme on Zircaloy-4/air oxidation was pursued and expanded to isothermal specimen exposure and the comparison of the oxidation between the atmospheres Ar/O{sub 2} and air. In close connection with the EC project OPSA, which is meanwhile terminated, the investigation concerned specimen exposure in a thermobalance to flowing atmospheres, namely dry Ar/O{sub 2} of composition 80/20 or synthetic air, respectively. As test parameters the linear heat-up rate was varied in the range 5 to 40 K/min and the ramp or holding temperature between 800 and 1500 C. Mass increase and reaction rate were continuously recorded or evaluated in temperature/time dependence. The oxide scale growth was found to be accompanied by colour changes, crack formation and spalling of layers, as well as by dimensional substrate growth, which are the reasons for the observed kinetic results. The microstructural investigation confirms nitrogen to be ...
The study design included an in vivo laboratory study. The objective of the study is to quantify the kinematics of the lumbar spinous processes in asymptomatic patients during un-restricted functional...Full Text Available
The biocompatibility and corrosion resistance of various materials for use as sacrificial anodes in in vivo hybrid fuel cells were studied. Aluminium, zinc, and magnesium alloy AZ31B were studied, and the results are discussed.
Objective: The aim of this study was to obtain an overview of the methodological quality of studies on the measurement properties of neck pain and disability questionnaires and to describe how well various aspects of the design and statistical analyses of studies on measurement properties are performed. Methods: A systematic review was performed of published studies on the measurement properties of neck pain and disability questionnaires. Two reviewers independently rated the quality of the studies using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. This checklist was developed in an international Delphi consensus study. Results: A total of 47 articles were included on the measurement properties of 8 different questionnaires. The meth...
I travelled to San Jose, Costa Rica on July 8, 1990 to evaluate all of the completed elements of the ongoing feasibility study for the San Lorenzo River hydroelectric project. The feasibility study is being supported by ORNL under the Renewable Energy Applications and Training Project. The project is being studied for implementation by CONELECTRICAS, a consortium of rural electric cooperatives and the study itself is being conducted by BEL Engineering, a Costa Rican consulting firm under contract to CONELECTRICAS, USAID/PIC and NRECA.
BackgroundMicroarray studies can supplement QTL studies by suggesting potential candidate genes in the QTL regions, which by themselves are too large to provide a limited selection...Full Text Available
Geographic information systems (GIS) are being used with increasing frequency in environmental epidemiology studies. Reported applications include locating the study population by geocoding addresses...Full Text Available
Toxicity and potential carcinogenicity studies of boric acid were investigated in mice to verify in a second rodent species that this was a noncarcinogenic chemical. Earlier chronic studies in rats...Full Text Available
Geometrical structures and energetic properties for different tautomers of adenine are calculated in this study, using multi-configurational wave functions. Both the ground and the lowest singlet excited state potential energy surfaces are studied. Four t...
Background and objectives: The Comprehensive Dialysis Study (CDS) aimed to understand factors contributing to physical, functional, and nutritional health status among patients starting dialysis.Design,...Full Text Available
BackgroundThere have been dramatic changes in the approach to screening for aneuploidy over the last 20 years. However, the approach to screening for other complications of pregnancy...Full Text Available
BackgroundThere is a lack of studies considering social disparity in oral health emanating from adolescents in low-income countries. This study aimed to assess socio-demographic...Full Text Available
Background and objectives: The objective of this study was to describe the prevalence of ocular fundus pathology in the Chronic Renal Insufficiency Cohort (CRIC) study, a multicenter, longitudinal study...Full Text Available
Study objectives:To verify the existence of a symptomatic form of restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and to identify possible associated risk factors.Design:Prospective,...Full Text Available
BackgroundDepression is a common illness, often treated in primary care. Many studies have reported undertreatment with antidepressants in primary care. Recently, some studies also...Full Text Available
AimsThe aims of the study were to study the effect of pre-operative treatment on the expression of tumour-related proteins and to correlate the expression of these...Full Text Available
OBJECTIVE. This study was conducted to determine whether an index for measuring quality of care for psychiatric emergencies is reliable and valid. DATA SOURCES/STUDY SETTING. The study used primary...Full Text Available
BackgroundGender differences in the prevalence and occupational consequences of musculoskeletal disorders (MSDs) are consistently found in epidemiological studies. The study investigated...Full Text Available
The authors studied noncancer mortality among phenoxyacid herbicide and chlorophenol production workers and sprayers included in an international study comprising 36 cohorts from 12 countries followed...Full Text Available
... see and electrophysiological study and catheter ablation with 3D mapping. During the procedure, doctors look at the ... perform a electrophysiology study with ablation, using our 3D mapping system. Keep in mind, that during the ...
The objectives of this study were to examine the association between dietary factors and underweight and overweight adult Vietnamese living in the rural areas of Vietnam. A cross-sectional study of...Full Text Available
The report gives background design data for a specific copper smelter. The data is sufficiently detailed to allow air pollution control system engineering studies to be conducted. These studies will be concerned primarily with lean SO2 streams that curren...
Experimental and imaging studies in monkeys have outlined various long association fiber bundles within the temporoparietal region. In the present study the trajectory of the middle longitudinal fascicle...Full Text Available
Studies of the associations between air pollution and hospital admissions and emergency room use are reviewed, including studies of air pollution episodes, time-series analyses, and cross-sectional...Full Text Available
Dimensional variability studies and published dimensional variability standards have been used by the foundry industry for years as an indicator of the casting process` ability to produce uniform parts. These studies are an extremely useful tool in the continuous ``dimensional dialogue`` between foundries and customers. The nature of these studies, and of the current tolerancing systems used by casting designers, leaves room for some misinterpretation and misuse of these study results. This paper contains two important discussions. The first part explains exactly what these studies represent. Following this is a brief explanation on dimensional and geometric tolerances and how they communicate dimensional requirements.
This paper gives a summary of a risk study assuming unprotected loss of flow (ULOF) in the SNR 300. This study was initiated in 1979/80 by the Karlsruhe Nuclear Research Center and performed in close cooperation with Science Applications Inc., Palo Alto, USA, and Interatom Company. Part of the results also was integrated in the 'Risk Related Analysis for the SNR 300' carried out by the Gesellschaft fuer Reactorsicherheit. The character of the study described here is similar to other risk studies like the Reactor Safety Study and the German Risk Study for Nuclear Power Plants. The objectives and the methodology of the analyses are described and its results are discussed. (orig./RW).
The focus of the Chernobyl Studies Project has now turned to the issue of health effects from the Chernobyl accident. Currently, we are involved in and making progress on the case-control and co-hort studies of thyroid diseases among Belarussian children. Dosimetric aspects are a fundamental part of these studies. We are working to implement similar studies in Ukraine. A major part of the effort of these projects is supporting these studies, both by providing methods and applications of dose reconstruction and by providing support and equipment for the medical teams.
A study of the electron beam dynamics in the linac is conducted for the FERMI free electron laser (FEL) founded for construction at the Sincrotrone Trieste.
A study of the electron beam dynamics in the linac is conducted for the FERMI free electron laser (FEL) founded for construction at the Sincrotrone Trieste
The stereocontrolled total synthesis of 4-hydroxydictyolactone (4), a member of the xenicane diterpene family of natural products, is described. These studies feature the development...Full Text Available
Several randomized studies have been completed in prostate cancer that show a benefit to immediate postoperative treatment in patients undergoing prostatectomy. In one of the studies, there was even...Full Text Available
Rationale and ObjectivesSample-size estimation is an important consideration when planning a receiver operating characteristic (ROC) study. The aim of this work was...Full Text Available
BackgroundSeveral studies have suggested an association between periodontal disease and prematurity but this finding has not been consistently observed.MethodsCase...Full Text Available
ObjectiveCOMBINE is the largest study of pharmacotherapy for alcoholism in the United States to date, designed to answer questions about the benefits of combining...Full Text Available
Lunar Geology is the study of the moons crust, rocks, strata, etc. Lunar Geology tends to cover two broad areas of study; Maria (and/or Basins) and Highlands. ...
FT-IR spectroscopic studies of major organic matter in carbonaceous chondrites using microscopic technique and comparison with terrestrial kerogen. ...
... elevated blood sugar levels, but not full-blown diabetes. What are the keys to preventing the disease? ... been well studied, in a study called The Diabetes Prevention Program, in several thousand people with this ...
Field studies among diverse biomes demonstrate that nitrogen concentration (% N) at leaf- and canopy-scales is strongly related to carbon uptake and cycling ...
A study of the effects of the action of phenoxybenzamine on bladder neck opening during micturition is reported. Twenty patients with symptoms of prostatism but minimal prostatic enlargement were studied....Full Text Available
Waste Technology and Innovation Study Final Report ...Waste Technology and Innovation Study Final Report 21/18569/150554 ...Survey of waste and resource recovery related technology and innovation, including products and product uses
The purpose of this study was to compare the clinical outcomes and wound complications in coccygectomy with or without subperiosteal resection. This retrospective study included 25 patients who underwent...Full Text Available
Studies were conducted in northern Bohemia to simultaneously evaluate personal exposures to air pollution in the form of respirable particles containing polycyclic aromatic hydrocarbons (PAHs) and biomarkers...Full Text Available
The research of the CELLO collaboration is reviewed. After a description of the CELLO detector tests of QCD and hadronic final states by determination of the strong coupling constant and studies of inclusive production of electrons and muons in multihadronic events in e"+e"- annihilation are described. Then studies of deep inelastic e#gamma# scattering with lepton pair production and the study of the structure function of the photon are briefly described. Finally studies on QED processes are described together with tau decays. (HSI).
This paper deals with dynamic study of co-generator system with derived dynamic models of generator, excitation system, and turbine/governor from field tests. Mainly this study concentrates on frequency control by under-frequency relay. We simulates dynamic study of co-generator system using EMTDC. (author). 4 refs., 13 figs., 4 tabs.
The transformation of two different types of glial cells has been studied using an in vivo-/in vitro model and a complete in vitro model. The purpose of the study and to define in vitro model systems is to study the the neoplastic transformation of pure populations of glial cells. Data are presented to demonstrate that the transformed cells are glial and tumorigenic. (ACR)
-Ecophysiological and floristic study of the lichen communities in .... Plasticity of the Lichen Catillaria corymbosa in Different Microhabitats of the ...
A survey was conducted to determine the sources of buildings energy conservation case studies and educational aids available in Canada. In total 785 consultants, educational institutions, building developers, manufacturers and government agencies were contacted. The results of this survey provide an indication of those agencies in Canada most actively involved with energy conservation in buildings, a listing of those agencies in Canada having case study information and/or educational aids materials available related to energy conservation in buildings, and a broad description of the subject area of the case studies and educational aids listed. The results of this study are intended to provide a source listing of energy conservation case studies and educational aids to the Buildings Energy Technology Transfer Program lead agencies and others conducting similar ...
Research conducted at Brookhaven National Laboratory under the Coastal Meteorology and Diffusion Research Program from 1972 to 1983 is summarized by the following study areas: Diffusion Studies, Boundary Layer Studies, Coastal Meteorology Studies, Air-Sea Interaction Studies, Coastal Transport and Diffusion Climatology, Seabreeze Modeling and Instrument Development, all supported by the US Department of Energy. Studies supported by the Nuclear Regulatory Commission, the National Science Foundation and the American Petroleum Institute are also described. A summary of a Workshop on Coastal Atmospheric Transport Processes, an account of studies in progress, recommendations for future research and a description of facilities and instrumentation available are also included. A list of all publications and presentations prepared as part of the ...
Objective: Results of reliability and agreement studies are intended to provide information about the amount of error inherent in any diagnosis, score, or measurement. The level of reliability and agreement among users of scales, instruments, or classifications is widely unknown. Therefore, there is a need for rigorously conducted interrater and intrarater reliability and agreement studies. Information about sample selection, study design, and statistical analysis is often incomplete. Because of inadequate reporting, interpretation and synthesis of study results are often difficult. Widely accepted criteria, standards, or guidelines for reporting reliability and agreement in the health care and medical field are lacking. The objective was to develop guidelines for reporting reliability and...
Experimental investigation data are systematized of free radical states and processes in irradiated proteins. The investigation is performed by the radiospectral methods. Results are discussed in detail of the study of free radicals electronic structure of amino acids, peptides and proteins formed by the action of ionizing radiation. The specificity is stressed of the study of monocrystalls of these compounds by the method of electronic paramagnetic resonance. The nature is also studied of primary centres formed under the effect of radiation on biologically important compounds and their subsequent reactions in solid and liquid solutions. Ion-radical states of different functional groups of the protein molecule are studied. Prospects of the study and the role of anion-radicals in biological processes are discusses.
Terror management theory (TMT) proposes that people who are reminded of their mortality should be motivated to defend their cultural worldview. Studies 1 and 2 examined whether the TMT worldview defence-buffering effect found in Western cultures could be generalized to Asians in Taiwan. No such effect was found in the present studies. This non-significant result was robust when either a stronger distraction task was used (study 1) or when a subliminal manipulation of mortality salience was utilized (study 2). A meta-analysis, including 24 TMT experiments in East Asia, was also conducted (study 3). The average effect size (d = 0.11, r = 0.055) of worldview defence among these experiments was not significantly different from zero. Study 4 found that mortality salience manipulation also did n...
Feasibility Study-II examined a high-performance Neutrino Factory providing 1 x 10{sup 20} neutrinos per year aimed at a long-baseline detector. The Study was sponsored jointly by BNL and the Neutrino Factory and Muon Collider Collaboration ration (MC) and is based on a 1 MW proton driver operating at 24 GeV, i.e., an upgraded version of the AGS accelerator. Compared with the earlier FNAL-sponsored study (Feasibility Study-I), there is a sixfold improvement in performance. Here we describe details of the implementation of Study-II concepts and discuss their efficacy. Alternative approaches that will be pursued in follow-on R and D activities are also described briefly.
In this book are found technical and scientific papers on the main works of the Direction of the Fuel Cycle (DCC) in France. The study fields are: the up-side of the nuclear fuel cycle with theoretical studies (plasma simulation) and technological developments and instrumentation (lasers diodes, carbides plasma projection, carbon 13 enrichment); the down-side nuclear fuel cycle with theoretical studies (ion Eu{sup 3+} complexation simulation, decay simulation, uranium and plutonium diffusion study, electrolyser operating simulation), scenario studies ( recycling, wastes management), experimental studies; dismantling and cleaning (soils cleaning, surface-active agent for decontamination, fault tree analysis); analysis with expert systems and mass spectrometry. (A.L.B.)
The objective of this study was to analyse one of the goals of the latest National Waste Plan of Finland: the relative reduction of hazardous waste (HW) generation by 15% over the period 1992 to 2005.Official statistics and a national database of the annual reports of HW generators were used as one basis for this study. A case study was focused on a selection of HW classes that were considered to be typical to the metal workshop industry. These HW classes were combined to form functional HW groups for the purpose of forming time series. Trends at the company level were studied by performing interviews and by studying the environmental permit documents of about 50 companies.The total amount of HW reported in Finland increased by 133% over the studied period. Meanwhile the GDP of Finland gre...
Bimaxillary protrusion is prevalent among Asians and anterior segmental osteotomies are commonly used for its surgical correction. The objective of this study was to evaluate the soft tissue changes resulting from anterior segmental osteotomies. The electronic databases PubMed, Scopus and ISI Web of knowledge were searched for potentially eligible studies using a set of predetermined keywords. Full texts meeting the inclusion criteria were retrieved and their references were manually searched for additional relevant articles. The study details and outcome data of these reports were extracted using spreadsheets for comparison. The methodological quality of each study was assessed. Eleven studies met the inclusion criteria. Lateral cephalometry was used in all studies. A reduction of the lab...
This report presents the data and results of a site specific case study comparing costs of an overhead line with an underground circuit traversing the same route. The costs used for the overhead line are actual numbers for a line scheduled to be built by a utility. The underground circuit costs were developed using the same criteria of line rating, contingencies, and location. Often cost comparisons between overhead and underground lines are made using figures taken from studies with widely varying assumptions. This project attempts to provide a comparison by studying the costs of overhead and underground lines following the same route and using the same design assumptions. Caution must be used, however, in extending the results of this study beyond its original intent. It is site-specific and may be representative of only one area of the country. 9 refs., 23 figs., 18 tabs.
The synapsin III gene, SYN3, which belongs to the family of synaptic vesicle-associated proteins, has been implicated in the modulation of neurotransmitter release and in synaptogenesis, suggesting a potential role in several neuropsychiatric diseases. The human SYN3 gene is located on chromosome 22q12-13, a candidate region implicated in previous linkage studies of schizophrenia. However, association studies of SYN3 and schizophrenia have produced inconsistent results. In this study, four SYN3 SNPs (rs133945 (-631 C>G), rs133946 (-196 G>A), rs9862 and rs1056484) were tested in three sets of totally 3759 samples that comprise 655 affected subjects and 626 controls in the Irish Case-Control Study of Schizophrenia (ICCSS), 1350 samples incorporating 273 pedigrees in the Irish Study of High D...
BackgroundIsoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease. In this study, we compared the transcriptional response...Full Text Available
BackgroundMost studies on children with chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) have been undertaken in tertiary care and little is known about their management...Full Text Available
The effects of consuming water with meals rather than drinking no beverage or various other beverages remains under-studied. This systematic review of English language studies compared the effects...Full Text Available
ObjectiveTo investigate the associations between intimate partner violence, rape and HIV among South African men.DesignCross-sectional study involving...Full Text Available
OBJECTIVESAlthough several studies suggest that slow gait speed is a predictor of falls, it may also be a protective mechanism to prevent falls. Further, fast walking...Full Text Available
AbstractIndividual informed consent is a key ethical obligation for clinical studies, but empirical studies show that key requirements are often not met. Common recommendations to strengthen...Full Text Available
A new type of radiation which occurs when particles are accelerated in the field of a longitudinal wave and in a transverse magnetic field is studied. The characteristics of such spontaneous radiation are obtained, and the influence of collective effects on the radiation is analyzed. The application of the findings to the theory of free electron lasers is discussed. 8 references.
1. The uptake and esterification to trigylceride of oleic acid in micellar form was studied in rat intestine in vitro. Sacs of the upper half of the everted intestine taken from bile...Full Text Available
A recent EPA-sponsored study of sediment and seafood contamination in Quincy Bay revealed elevated levels of several complex organic pollutants frequently of concern in human health assessments. A seafood...Full Text Available
BackgroundSome epidemiologic studies have suggested an association between electromagnetic field exposure induced by high voltage power lines and childhood leukemia, but null results...Full Text Available
Accurate engineering cost estimates are critical in developing bids for new work, and for effective resource allocation and project control. This study reports on design estimating methods found in the literature, and on the results of two empirical studies of how estimating techniques are used in professional practice and their accuracy. The study found great reliance on a classic {open_quotes}activity analysis{close_quotes} approach to estimating design resources, and significant hazards in commonly used parametric techniques. The study found that project managers expect their estimates to be accurate (with 80% confidence interval) of between -10% to +25%. The study also found that actual bids between engineering firms had a much greater range (-40% to +45%) than can be explained by accuracy. Perhaps most importantly the study found that none of the sampled ...
ObjectivesMild Cognitive Impairment (MCI) case-finding criteria have low specificity in general population studies. The present study retrospectively identifies cases...Full Text Available
BackgroundAn abdominal aortic aneurysm (AAA) that is identified when the abdomen is imaged for some other reason is known as an incidental AAA. No population-based studies have...Full Text Available
BackgroundIrritable bowel syndrome (IBS) and functional dyspepsia (FD) show considerable overlap and are both associated with psychiatric comorbidity. The present study aimed to...Full Text Available
In vivo plasminogen responses to various stimuli were studied. Plasminogen-125I was prepared and used first for metabolic studies of plasminogen in control dogs. The average results were:...Full Text Available
PURPOSE: Visual loss following panretinal photocoagulation was found in the Diabetic Retinopathy and the Early Treatment Diabetic Retinopathy Studies. This study was designed to test the hypothesis...Full Text Available
Ocular movements were studied electro-oculographically in 10 normal subjects and 10 patients with alternating strabismus. Fixation and pursuit movements and to a less extent the saccadic movements were...Full Text Available
Various hypotheses have been proposed to explain the molecule processes of sarcomere assembly, partially due to the lack of systematic genetic studies of sarcomeric genes in an in vivo...Full Text Available
A number of studies have examined the functional roles of individual muscles during normal walking, but few studies have examined which are the primary muscles that respond to changes in external...Full Text Available
A feasibility study to determine what materials and geometric systems would be required for fabrication of a camouflage system that would instantaneously cover a military vehicle in order to disrupt its characteristic shape or outline. The program involve...
In the information age, information utilities like libraries are as sensitive to the stresses of change as any other organization. This article is a case study of a small, specialized medical library...Full Text Available
This paper describes a new technique that can be used to study chloroplast volume regulation in vivo. Nuclear magnetic resonance spectroscopy was used to measure relative amounts of chloroplast water...Full Text Available
ObjectiveThis study was conducted to provide a nationwide analysis on barriers to cervical cancer screening in Korea.MethodsData used for this study...Full Text Available
Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity...Full Text Available
Available in vitro and animal studies have shown cancer protective effects of tea polyphenols. Recent study suggests a greater protective effect of green tea intake on breast cancer...Full Text Available
Eight of 100 normotensive children who had pyelonephritic scarring secondary to urinary infection and vesicoureteric reflux were found in an earlier study to have increased plasma renin activity (PRA)....Full Text Available
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. Employing strict significance thresholds when testing individual SNPs avoids false positives at...Full Text Available
The immunogenicity of allogeneic cultured human epidermal keratinocytes (cHEKs) has been studied in several models with contradictory results. We studied human T-cell activation in an in vitro...Full Text Available
Measurement of intrathylakoid aqueous volumes by electron spin resonance spectroscopy was used to study ionic permeability properties of thylakoid membranes isolated from Beta vulgaris...Full Text Available
Electron spin resonance (ESR) studies have been performed on spin-labeled model membranes aligned using the isopotential spin-dry ultracentrifugation (ISDU) method of Clark and Rothschild. This method...Full Text Available
This article presents a study identifying benefits and challenges of a novel hospital-to-hospital information technology (IT) outsourcing partnership (HHP). The partnership is an innovative response...Full Text Available
This study effort was required as a preliminary step prior to initiation of field measurements of atmospheric dispersion in coastal regions. The Nuclear Regulatory Commission (NRC) is in the process of planning an extensive field measurement program to generate data which will serve as improved data bases for licensing decisions, confirmation of regulations, standards, and guides, and for site characterizations. The study being reported here is an effort directed to obtaining as much information as is possible from existing studies that is relevant toward NRC's objectives. For this study, reports covering research and meteorological measurements conducted for industrial purposes, utility needs, military objectives, and academic studies were obtained and critically reviewed in light of NRC's current data needs. This report provides an interpretation of the extent of ...
Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully...Full Text Available
Because the results with cobalt-57-bleomycin (57Co-bleo) as a tumour-seeking agent in patients with pulmonary tumours were promising, a prospective study was carried out to test the sensitivity and...Full Text Available
In a combined clinical, radiological, and laboratory study of 77 patients throughout the leprosy spectrum, 10 patients had an enthesitis which has not been described previously as far as is known and...Full Text Available
The effect of potential risk factors for chronic lymphatic leukaemia was evaluated in a case-referent study encompassing 111 cases and 431 randomised referents, all alive. Information on exposure was...Full Text Available
A case-control study has been carried out to examine the occurrence of childhood cancer in relation to the proximity of overhead power lines to a child's home address at birth and to the calculated...Full Text Available
The effects of the time and temperature of alkaline pretreatment and the time and temperature of the carboxymethylation of peat in 2-propanol on the concentration of carboxymethyl groups and the solubility of the resulting products in water and an aqueous alkali solution were studied. The viscosity characteristics of the aqueous and aqueous alkaline solutions of peat carboxymethylation products were studied.
BackgroundSepsis or bacteraemia, however rare, is a significant cause of high mortality and serious complications in children. In previous studies skin disease or skin infections...Full Text Available
IntroductionTransfusion is a common treatment in pediatric intensive care units (PICUs). Studies in adults suggest that prolonged storage of red blood cell units is associated with...Full Text Available
Model systems to study the effects of chemicals of environmental concern on bacterial and parasitic diseases as well as the immunosurveillance and destruction of transplantable tumor cells were described...Full Text Available
The current study examined the reinforcing effects of choosing among alternatives in a four-part evaluation. In the first study, initial-link responses in a concurrent-chains arrangement resulted in...Full Text Available
The authors present differential scanning calorimetry (DSC) and in situ Moessbauer spectroscopy results for Metglas ribbons, to which different heat treatments were made. The Curie temperature of the amorphous phase is determined and the evolution of the magnetic field of this phase is studied as a function of temperature
Study of the conversion of chicken litter to biogas for the production of energy. There was an additional requirement that after extracting the energy from the chicken litter the nutrient value of the raw chicken litter had to be returned to the Ak-Chin Farms for use as fertilizer in a form and delivery method acceptable to the Farm.
The question of whether storage of red blood cells (RBCs) alters their capacity to deliver oxygen and affects patient outcomes remains in a state of clinical equipoise. Studies of the changes...Full Text Available
The existence and importance of an accelerated adjacent segment disc degeneration (ASD) after lumbar fusion have previously not been demonstrated by RCTs. The objectives of this study were, to determine...Full Text Available
AIM: To examine the determinants of maternal-neonatal transmission of hepatitis B virus (HBV).METHODS: A nested case-control study was conducted in Changsha, Hunan, People’s Republic...Full Text Available
OBJECTIVES--This case cohort study examines whether there is an association between exposure to electric and magnetic fields and suicide in a population of 21,744 male electrical utility workers from...Full Text Available
This study examines the longitudinal relationship between personal and sexual partner incarceration and subsequent HIV risk behaviors among drug-involved men and their primary female sexual...Full Text Available
BackgroundFew studies have yet addressed the effects of di(2-ethylhexyl) phthalate (DEHP) in house dust on human nasal mucosa.ObjectivesWe investigated...Full Text Available
Objectives:There is no study about correlation between vitamin D serum level and multiple sclerosis (MS) in Iran. So in this survey, we investigated the serum level of 25-hydroxy...Full Text Available