east cancer consortium: Topics by WorldWideScience.org

Management of young onset colorectal cancer: divergent practice in the East of England

Following the Chernobyl accident of April 1986, there has been a continual increase in the numbers of reported cases of childhood thyroid carcinoma. An EC-supported consortium to study the pathology and molecular biology of the thyroid cancers is being coordinated from the University of Cambridge. This paper reports the findings of this study so far, together with its recommendations for further studies. (author).

1997-12-01

2

British Library Electronic Table of Contents (United Kingdom)

Abstract Aim- According to the revised Bethesda Guidelines, colorectal cancer (CRC) occurring under age 50-years should be screened to exclude Lynch syndrome. However, in current practice in East Anglia, tumour screening is initiated only after genetics referral, reserved for those with a strong pedigree. This study aimed to determine how many patients with young-onset CRC undergo tumour screening in hospitals in East Anglia. Method- A retrospective case notes review over 5-years in four hospitals was undertaken to determine what proportion of those with young-onset CRC underwent referral for tumour screening and to assess local practices in terms of patient counselling and management. Results- One hundred and twenty-two patients were included. There was an average yearly caseload of 6-9 p...

2011-01-01

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A phase II trial of sorafenib in first-line metastatic urothelial cancer: a study of the PMH Phase II Consortium

British Library Electronic Table of Contents (United Kingdom)

Summary Background Sorafenib is an oral multikinase inhibitor that blocks cell proliferation via the ERK pathway and angiogenesis via the VEGF pathway. This phase II trial was conducted to determine the efficacy and tolerability of sorafenib for the treatment of patients with metastatic urothelial cancer (UC) who had not had prior chemotherapy for advanced disease. Patients and Methods Seventeen chemo-na?ve UC patients with adequate performance status and organ function were treated with sorafenib 400?mg twice daily on a continuous basis until progression or unacceptable toxicity. The primary endpoint was objective tumor response rate as measured by RECIST criteria. Secondary endpoints included rate of prolonged stable disease (>3?months), time to progression, median and 1?yr survival and ...

2011-01-01

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An integrated genome research network for studying the genetics of alcohol addiction

British Library Electronic Table of Contents (United Kingdom)

Abstract Alcohol drinking is highly prevalent in many cultures and contributes to the global burden of disease. In fact, it was shown that alcohol constitutes 3.2% of all worldwide deaths in the year 2006 and is linked to more than 60 diseases, including cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders, injuries and foetal alcohol syndrome. Alcoholism, which has been proven to have a high genetic load, is one potentially fatal consequence of chronic heavy alcohol consumption, and may be regarded as one of the most prevalent neuropsychiatric diseases afflicting our society today. The aim of the integrated genome research network -Genetics of Alcohol Addiction--which is a German inter-/trans-disciplinary life science consortium consisting of molecular biologists,...

2010-01-01

5

Surmounting the Unique Challenges in Health Disparities Education: A Multi-Institution Qualitative Study

BackgroundThe National Consortium for Multicultural Education for Health Professionals (Consortium) comprises educators representing 18 US medical schools, funded by the National...Full Text Available

2010-05-01

6

Interview With TV Asia

Terra Nova tow-out poised as next East Coast event

Countries and Regions A-Z List of Countries and Other Areas Africa (Sub-Sahara) East Asia and the Pacific Europe and Eurasia Near East (northern Africa, Middle East) South and...

2011-08-14

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SOVIET SPACE EXPLORATION AS VIEWED BY EAST ...

This spring, Newfoundland will send off a floating production, storage and offloading (FPSO) vessel to the offshore Terra Nova field. The Terra Nova will proceed southeast through Bull Arm, then northeast out of Trinity Bay, then heads southeast to the Jeanne d'Arc Basin on the Grand Banks. The Terra Nova is expected to produce 115,000 barrels of oil per day for six years, when it reaches full capacity. The consortium, headed by Petro-Canada as senior ownership partner and operator, built an environment protection program into every aspect of the project. Some of the features of the environment protection program include glory holes excavated on the ocean floor for the protection of production equipment from icebergs, to a flare stack on the platform, which has four legs to provide stability in rough seas. The FPSO was designed to withstand sea ice, icebergs, and severe winter storms. Flow lines are also protected, and in the event that a line is damaged, ...

2001-01-15

8

Radiation epidemiological analysis of late effects of population exposure at northern part of east ural radioactive trace

... Accession Number : AD0624575. Title : SOVIET SPACE EXPLORATION AS VIEWED BY EAST GERMAN SPECIALISTS,. ...

1965-11-15

9

Army Accessions Research Consortium, Shaping the Future ...

Population residing in the northern part of the Chelyabinsk oblast and the south eastern part of the Sverdlovsk oblast of Russia affected to accidental exposure since 1957. The territory (East Ural Radioactive Trace - EURT) was contaminated after explosion of container with highly radioactive wastes at the Mayak Production Association. Studies of health effects of exposure in the southern, head part of EURT are conducted in the Ural Research and Practical Center of Radiation Medicine (U.R.P.R.M.). In the 1990's U.R.P.C.R.M. formed a cohort of EURT within Chelyabinsk oblast (14,500 cases and 19,400 external controls). The cohort was followed in 1957-1987 and the results of the study are discussed by Crestinina et al. First results of study on exposure late health effects among rural population in the northern part of the EURT are presented in this paper. Firstly, or the period 1958-2000 a statistically significant increase in cancer ...

2006-07-01

10

The Obama Administration's Priorities in South and Central Asia

... implementation this might look like a new Developmental Counseling Form or Soldier Evaluation Report (SER) much like the OER/NCOER that will ...

2010-04-01

11

Machine condition monitoring

Countries and Regions A-Z List of Countries and Other Areas Africa (Sub-Sahara) East Asia and the Pacific Europe and Eurasia Near East (northern Africa, Middle East) South and...

2011-08-14

12

A consortium has been formed to undertake the design and development work necessary to establish a comprehensive machine condition monitoring (MCM) and diagnostic system for hydroelectric generating units. By working closely with participating utilities and interested manufacturers, the consortium is initiating the integration of existing and developing technologies into a comprehensive, modular, on- and off-line hydroelectric MCM system.

1995-12-31

13

Thyroid cancer incidence

Thyroid cancer in the Ukraine

Short communication.

1992-11-12

14

Creation of the BioBank, Early Detection and Discovery Biomarkers

Short communication.

1995-06-01

15

On Climatic Characteristics in the East Asian Seas by satellite data(NOAA, Topex/Poseidon)

Pancreatic Cancer; Head and Neck Cancer; Breast Cancer

2011-04-03

16

Impact of IODM and ENSO on the East Asian Monsoon: Simulations through NCAR Community Atmospheric Model

Full Text Available

2001-12-01

17

Cooperative research in coal liquefaction infratechnology and generic technology development: Final report, January 1, 1987 to April 30, 1988

Full Text Available

2005-12-01

18

Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium

The Consortium for Fossil Fuel Liquefaction Science (CFFLS) is a research consortium that includes five universities and a state energy laboratory. The membership is comprised of Auburn University, the University of Kentucky, the University of Pittsburgh, the University of Utah, West Virginia University, and the Kentucky Energy Cabinet Laboratory. The Consortium was formed in 1984 in response to the concern of the faculty and scientists at these institutions over the decline of coal liquefaction research in the United States, particularly long-range, basic research. Significant progress towards these goals was made in the current contract period. Major research accomplishments are presented on coal desulfurization, coprocessing, pyrolysis, enhanced reactivity, characterization, resource evaluation and database development. 108 refs., 90 figs., 38 tabs.

1988-05-10

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Progress of the BT-EdF-CEA project. The lithium polymer battery; Avancees du projet BT-EdF-CEA. Batterie lithium polymere

BackgroundThe occurrence of diabetes has greatly increased in low- and middle-income countries, particularly in Asia, as has the prevalence of overweight and obesity; in European-derived...Full Text Available

20

Midwest Superconductivity Consortium: 1994 Progress report

The lithium-polymer energy storage technology requires the production of thin films of huge surface. The BT-EdF-CEA consortium has studied the various manufacturing techniques of these films and their assembly. The process was chosen according to its productivity, low expensiveness, ecological impact and energy performances with capacities reaching 40 Ah. This paper explains: the objectives and specifications of the project, the advantage of the consortium and the role of the different partners, the results (coating, dry extrusion and battery element manufacturing techniques), and the electrochemical performances of the elements. (J.S.)

1996-12-31

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Radiation Therapy in Treating Patients With Prostate Cancer

The mission of the Midwest Superconductivity Consortium, MISCON, is to advance the science and understanding of high {Tc} superconductivity. During the past year, 27 projects produced over 123 talks and 139 publications. Group activities and interactions involved 2 MISCON group meetings (held in August and January); with the second MISCON Workshop held in August; 13 external speakers; 79 collaborations (with universities, industry, Federal laboratories, and foreign research centers); and 48 exchanges of samples and/or measurements. Research achievements this past year focused on understanding the effects of processing phenomena on structure-property interrelationships and the fundamental nature of transport properties in high-temperature superconductors.

1995-01-01

22

Thyroid cancer after Chernobyl; and reply

Prostate Cancer; Psychosocial Effects of Cancer and Its Treatment; Radiation Toxicity; Sexual Dysfunction and Infertility

2011-09-13

23

Surgical management of pancreatic cancer

Short communication.

1992-09-03

24

State Cancer Profiles Home Page

Full Text Available

2008-02-01

25

Childhood thyroid cancer in Belarus

Washington West Virginia Wisconsin Wyoming Cancer --- Choose a Cancer Site --- All Cancer Sites Bladder Brain & ONS Breast (Female) Breast (Female in situ) Cervix Childhood...

2011-10-15

26

Hazard Evaluation and Technical Assistance Report No. TA 76-100, ASARCO, East Helena, Montana.

Short communication.

1992-10-22

27

Does Water Hyacinth on East African Lakes Promote Cholera Outbreaks?

A Hazard Evaluation and Technical Assistance investigation was performed by NIOSH on February 1-4, 1977, at ASARCO, East Helena, Montana, a facility engaged in lead smelting. The survey was prompted by a request from the Regional OSHA Director in referenc...

1977-01-01

28

Cholera outbreaks continue to occur regularly in Africa. Cholera has been associated with proximity to lakes in East Africa, and Vibrio cholerae has been found experimentally to concentrate...Full Text Available

2010-08-05

29

Diastatomma bicolor

Bedload measurements, East Fork River, Wyoming

... east Nigeria) and has also been recorded from south west Cameroon. Only two records; that from Angola the locality ... east Nigeria) and has also been recorded from south-west Cameroon. It is inferred tha...

30

SNP diversity of Enterococcus faecalis and Enterococcus faecium in a South East Queensland waterway, Australia, and associated antibiotic resistance gene profiles.

A bedload trap in the riverbed provided direct quantitative measurement of debris-transport rate in the East Fork River, Wyoming, a basin of 466 km² drainage area. Traction load moves only...Full Text Available

1976-04-01

31

Petrographically deduced triassic climate for the Deep River Basin, eastern piedmont of North Carolina

PMID:21910889

2011-09-12

32

Recent Reviews in Carcinogenesis 1981.

A petrographic comparison of Triassic, fluvial sandstones from the Deep River Basin in the eastern piedmont of North Carolina with nearby Holocene stream sands (1) indicates that he Triassic climate was more arid than today's and (2) distinguishes an eastern, more plutonic terrane from a western, more metamorphic source terrane. The paleoclimatic interpretation is based on differences in framework composition between modern and ancient sands of the same grain size, derived from the same rock type, transported similar distances and deposited in similar settings. The Triassic sandstones contain more lithic-fragments but less quartz than otherwise equivalent, modern sand in the Deep River Basin. Feldspar content is more complex, controlled by both source-rock composition and climate. Sand from the more plutonic terrane contains more feldspar and plutonic lithic-fragments than sand from the more metamorphic terrane, which contains more quartz and metamorphic lithic-fragments. This ...

1985-01-01

33

Recent Reviews in Carcinogenesis is a service of the International Cancer Research Data Bank (ICRDB) Program of the National Cancer Institute, intended to facilitate and promote the exchange of information between cancer scientists. It contains abstracts ...

1982-01-01

34

Managing Cancer Pain

A case of Meigs syndrome mimicking metastatic breast carcinoma

Despite the existence of effective analgesic drugs, many cancer patients live and die with ineffective pain control. The control of cancer pain is largely achievable with the appropriate use of available...Full Text Available

1984-02-01

35

[A giant ulcer of the stomach with perforation into the liver simulating cancer].

BackgroundAdnexal masses are not uncommon in patients with breast cancer. Breast cancer and ovarian malignancies are known to be associated. In patients with breast cancer and co-existing...Full Text Available

36

The Differential Expression of Aqueous Soluble Proteins in Breast Normal and Cancerous Tissues in Relation to Stage and Grade of Patients

PMID:9163165

1996-01-01

37

Sampling the Spatial Patterns of Cancer: Optimized Biopsy Procedures for Estimating Prostate Cancer Volume and Gleason Score

Breast cancer is a leading cause of female deaths worldwide. In Malaysia, it is the most common form of female cancer while Infiltrating ductal carcinoma (IDC) is the most common form of breast cancer....Full Text Available

2010-01-01

38

Permanent Brachytherapy of Localized Prostate Cancer: Preliminary Results

Prostate biopsy is the current gold-standard procedure for prostate cancer diagnosis. Existing prostate biopsy procedures have been mostly focusing on detecting cancer presence. However, they...Full Text Available

2009-08-01

39

Monitoring of Tumor Promotion and Progression in a Mouse Model of Inflammation-Induced Colon Cancer with Magnetic Resonance Colonography1

Full Text Available

2011-06-01

40

Modulation of MnSOD in Cancer: Epidemiological and Experimental Evidences

Early detection of precancerous tissue has significantly improved survival of most cancers including colorectal cancer (CRC). Animal models designed to study the early stages of cancer are valuable...Full Text Available

2009-03-01

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Modulation of Benzene Metabolism by Exposure to Environment

Full Text Available

2010-06-01

42

Military workingn> dogs may be a sentinel for human cancer.

Lung Diseases; Cancer

2005-06-23

43

Current National Cancer Institute Center programs.

PMID:2348465

1990-06-20

44

Change of telomerase activity in rectal cancer with chemoradiation therapy.

PMID:5017351

1972-04-01

45

A Feasibility Study of Smoking Cessation Program in Radiation Oncology

Full Text Available

2000-04-01

46

Report of the results of the fiscal 1997 regional consortium R and D project. Regional consortium energy field / R and D mesoscopic organ control heat-resistant / wear-resistant metal group composite materials (first fiscal year); 1997 nendo chiiki consortium kenkyu kaihatsu jigyo. Chiiki consortium energy bun`ya / mesoscopic fukuso soshiki seigyo tainetsu taimamosei kinzokuki fukugo zairyo no kenkyu kaihatsu (daiichi nendo) seika hokokusho

Cancer and Tobacco Abuse

2007-10-29

47

British Retail Consortium - BRC Services

Out of the R and D of mesoscopic metal group composite materials, the paper described the fiscal 1997 results. In the in-situ method as a composite material making method, elucidated to some degree were chemical composition of Fe-C-Cr-V-Nb-Mo-W-Ni base multi-dimensional alloys, and wear resistance and oxidation resistance of MC type carbide dispersion multi-phase texture crystallizing as primary crystal and eutectic. In the composite material making with ceramic fiber and alloy by the pressure infiltration method, the paper clarified the texture formation mechanism in solidification/heat treatment by a combination of Al alloys and alumina long fiber, and the relation between fiber configuration and wear resistance. By MA and MG methods as the powder metallurgy composite material making method, a composed body of {alpha}-stainless steel of Fe-12%Cr composition and M23C6 of 40-90vol% are designed for alloy composition, and powder of amorphous or hyperfine texture was fabricated. By hot ...

1998-03-01

48

Battery Life Estimator Manual Linear Modeling and Simulation

... IN-STORE PROCUREMENT SERVICES - Energy (Electric/Gas) - Telecoms (Call/Lines/Switchboards/Mobiles) - Waste & waste compliance (Cleaning/Collection/Compliance) - Carrier bags (Plastic/Paper) - Stationery (Supplies) - Catering (Consumables/Equipment) - Insurance (Business/Legal/Personal) - Water (Rates/Coolers) - Personnel (Staff Uniforms/Recruitment/Training) - Security (Patrols/Surveillance Equipment) - Instore ...

49

(Feasibility study of the San Lorenzo River hydroelectric project)

The Battery Life Estimator (BLE) Manual has been prepared to assist developers in their efforts to estimate the calendar life of advanced batteries for automotive applications. Testing requirements and procedures are defined by the various manuals previously published under the United States Advanced Battery Consortium (USABC). The purpose of this manual is to describe and standardize a method for estimating calendar life based on statistical models and degradation data acquired from typical USABC battery testing.

2009-08-01

50

Regulation of Cancer-Causing Food Additives-Time for a ...

I travelled to San Jose, Costa Rica on July 8, 1990 to evaluate all of the completed elements of the ongoing feasibility study for the San Lorenzo River hydroelectric project. The feasibility study is being supported by ORNL under the Renewable Energy Applications and Training Project. The project is being studied for implementation by CONELECTRICAS, a consortium of rural electric cooperatives and the study itself is being conducted by BEL Engineering, a Costa Rican consulting firm under contract to CONELECTRICAS, USAID/PIC and NRECA.

1990-07-19

51

Radiation Therapy and Cisplatin With or Without Amifostine in Treating Patients With Stage IIIB or Stage IVA Cancer of the Cervix

... Accession Number : ADA145145. Title : Regulation of Cancer-Causing Food Additives-Time for a Change? Corporate Author ...

1981-12-11

52

The Financial War on Terrorism: Grading US Strategy for ...

Cervical Cancer; Radiation Toxicity

2011-09-09

53

Task Force Butler: A Case Study in the Employment of an Ad ...

... that operated in Pakistan, Dubai, and throughout the Middle East ... identifies 'funds' as one of eight major terrorist ... techniques, and procedures (TTP). ...

2006-04-15

54

Public Health Assessment - Bangor Naval Submarine Base and Bangor Ordnance Disposal (US Navy) - Silverdale, Kitsap ...

... east. The two most important offensives, Operation EPSOM (25 June to 1 July 1944) and Operation GOODWOOD (18 to ...

2007-12-14

55

Multiple-Purpose Project, Little Blue River Basis East Fork ...

Naval Submarine Base, Bangor (Bangor) is located on the Kitsap Peninsula along the east shore of Hood Canal in ... ...

56

... 146 27 1 Aug 83, outlet works excavation. Sewer pipe installation. ... No. 157. Outlet works excavation. Sewer pipe installation. ...

1990-09-01

57

Marines Pictures

Team 6 Regimental Combat Team 8 Retired Activities Office Safety Division School of Infantry - East School of Infantry - West Second Low Altitude Air Defense Battalion Security...

2011-09-24

58

Korea, South

JPRS Report, Near East & South Asia, Israel

Health Iran Iraq Landmines Middle East Muslim Outreach Narcotics Nonproliferation North Korea Pakistan Piracy Reconstruction and Stabilization Sudan Trafficking in Persons War...

2011-10-09

59

JPRS Report, East Asia: Southeast Asia.

... more so when that and he is leaving it with ... reminds me of the story about the sick man who ... fers based on industrial cooperation and the establish- ...

1991-09-11

60

... of the Philippines]-US Treaty of Friendship, Cooperation and Security is also causing some apprehen- sion among Taiwanese business sector, the ...

1991-11-20

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61

Health Concerns in Haiti

Asian Security Challenges-Planning in the Face of Strategic ...

Issues Democracy and Human Rights Economic Issues Energy Security Food Security Haiti Health Iran Iraq Landmines Middle East Muslim Outreach Narcotics Nonproliferation North Korea...

2011-08-28

62

Antithrombotic Prophylaxis in the Middle East

... times, in Iran (Persia), the Arabian Gulf region, East Africa, territories of the former Ottoman Empire, parts of Eastern Europe ...

1994-10-01

63

Thyroid cancer stem cells

Several factors have been proposed to explain the persistence of a high incidence of venous thromboembolism worldwide with its associated morbidity and mortality. Underutilization of anticoagulants...Full Text Available

64

British Library Electronic Table of Contents (United Kingdom)

Thyroid cancer is the most frequently diagnosed endocrine cancer and causes more deaths than all other endocrine cancers combined. Research findings support the concept that a subpopulation of thyroid cancer cells displays properties characteristic of stem cells. These putative cancer-forming entities drive tumorigenesis as a result of their dual ability to undergo self-renewal and to differentiate into various types of cancer cells; they also mediate metastasis and are resistant to the effects of chemotherapy and radiation therapy. This Review discusses the cellular origin of thyroid cancer and the properties of the thyroid cancer stem cell niche. The article critically evaluates the methods used to identify molecular markers expressed by thyroid-cancer-initiating cells and outlines prosp...

2011-01-01

65

The Complete Genome Sequence of Yersinia pseudotuberculosis IP31758, the Causative Agent of Far East Scarlet-Like Fever

Report on Invasive Disease and Meningitis due to Haemophilus influenzae and Streptococcus pneumonia from The Network for Surveillance of Pneumococcal diseases in the East African Region (netSPEAR)

The first reported Far East scarlet-like fever (FESLF) epidemic swept the Pacific coastal region of Russia in the late 1950s. Symptoms of the severe infection included erythematous skin rash and desquamation,...Full Text Available

2007-08-01

66

Radiological assessment report for the Lansdowne property, 105-107 East Stratford Avenue, Lansdowne, Pennsylvania, October-December 1984

Pneumococcal disease in young children has not been as well characterized in East Africa as it has been in industrialized countries. Although pneumococci are likely to cause substantial mortality...Full Text Available

2009-03-01

67

Bring money and natural gas; Part 5: The activities of Dutch companies in the East European natural gas market. Geld en gas meebrengen; Deel 5: Nederlandse bedrijven actief op de Oosteuropese gasmarkt

Areas with elevated levels of radioactivity were found throughout both residences, as well as on the surrounding property. Contamination was also found in the garage behind the 105 East structure. The 105 East residence had substantially more contamination than the 107 East residence, as was expected. The chimneys, particularly the rear chimney, from the 105 East residence had extensive contamination, indicating that contaminated materials may have been burned at the site. The high background radiation emanating from this residence made it difficult to establish the relatively lower levels of contamination in the 107 East residence. The property surrounding the 105 East residence was found to have substantial contamination scattered throughout, with the highest level occurring in the backyard. The soil surface contamination seemed to drop markedly (but not ...

1985-09-01

68

Financial resources for development. Capital markets in developing countries: a study on borrowing by developing countries in the emerging capital markets of the Middle East

The budding natural gas markets in East Europe attract a great deal of interest from natural gas industries in the Western countries. Dutch companies, institutions and the government, too, are active in this market. So far the results have not been spectacular. An analysis is made of the present situation and the Dutch approach

1993-09-01

69

Dynamics of the Intertropical Convergence Zone of the East Pacific.

Private transfers of capital from the Organization of Petroleum Exporting Countries (OPEC) to developing countries are intended to complement private transfers from the Organization of Economic Cooperation and Development (OECD) by tapping the emerging capital markets in the Middle East. Developing countries will be able to diversify their borrowing and gain additional financing. The long-term investment of oil-producing countries will benefit and the pressures on the banking institutions to recycle funds will lessen. Middle East capital markets include international loans and international bonds. The history of the Kuwaiti dinar (KD) bond market, with its advantages for both investors and borrowers, illustrates the successful development of a capital market. Financial intermediation needs to be improved, however, if the Middle East is to become efficient enough to compete with the Euromarkets. Efficiency will require ...

1980-10-01

70

Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation

The dynamical factors controlling the mean state and variability of the east Pacific intertropical convergence zone (ITCZ) and the associated cross-equatorial boundary layer flow are investigated using observations from the East Pacific Investigation of Climate (EPIC2001) project. The tropical east Pacific exhibits a southerly boundary layer flow that terminates in the ITCZ. This flow is induced by the strong meridional sea surface temperature (SST) gradient in the region. Away from the equator and from deep convection, it is reasonably well described on a day-to-day basis by an extended Ekman balance model. Variability in the strength and northward extent of this flow is caused by variations in free-tropospheric pressure gradients that either reinforce or oppose the pressure gradient associated with the SST gradient. These free-tropospheric gradients are caused by easterly waves, tropical cyclones, and the Madden Julian ...

2006-02-01

71

British Library Electronic Table of Contents (United Kingdom)

Colorectal cancer is the second most common cause of cancer death in the world and about half of the patients with colorectal cancer require adjuvant therapy after surgical resection. Therefore, the eradication of cancer cells via chemotherapy constitutes a viable approach to treating patients with colorectal cancer. In this study, the effects of bufalin isolated from a traditional Chinese medicine were evaluated and characterized in HT-29 and Caco-2 human colon cancer cells. Contrary to its well-documented apoptosis-promoting activity in other cancer cells, bufalin did not cause caspase-dependent cell death in colon cancer cells, as indicated by the absence of significant early apoptosis as well as poly(ADP-ribose) polymerase and caspase-3 cleavage. Instead, bufalin activated an autophagy...

2011-01-01

72

[Center on Student Testing, Evaluation, and Standards Setting.] Research and Development Mission. Final Performance Report.

Toward success of a market mobilization effort: the National Earth Comfort Program

A consortium of four institutions, based at Western Michigan University, was to plan a Research and Development Center on Student Testing, Evaluation, and Standards Setting. The four consortium sites are Boston College, the Dallas Independent School District, the University of Kansas, and Western Michigan University. This report is a final performance report for the planning grant made to Western Michigan University by the National Institute of Education. The first section provides a summary of the planning activities actually conducted under the grant. It includes a description of particular problems and successes, a list of participants and their affiliations, and an evaluation report for the planning project. The second section is a technical report on the Research and Development (R and D) mission for the Center. It updates the mission and strategy statement contained in the planning grant application and includes an agenda, with ...

1985-09-01

73

Planning logistics operations in the oil industry

Work of the Geothermal Heat Pump Consortium (GHPC), a joint program of the US Department of Energy, the US Environmental Protection Agency, the US electric utilities and industry was described. The consortium was established to improve energy efficiency and reduce CO{sub 2} emissions by moving ground source and groundwater source heat pumps from niche products to ten percent of the new and retrofit HVAC market in less than a decade. The GHPC program focuses on : (1) reducing first costs through technology innovation and innovative financing, (2) strengthening the infrastructure though education, training and work codes and regulations, and (3) building confidence in the technology through demonstrations of cost-effectiveness, low maintenance efforts and through marketing programs. Results of the first two years of operations were described. Results indicate that the objectives are being achieved, the number of installations is increasing and a ...

1997-11-01

74

ANL's electric vehicle battery activities for USABC. [US Advanced Battery Consortium (USABC)

In this paper we apply stochastic programming modelling and solution techniques to planning problems for a consortium of oil companies. A multiperiod supply, transformation and distribution scheduling problem - the Depot and Refinery Optimization Problem (DROP) - is formulated for strategic or tactical level planning of the consortium's activities. This deterministic model is used as a basis for implementing a stochastic programming formulation with uncertainty in the product demands and spot supply costs (DROPS), whose solution process utilizes the deterministic equivalent linear programming problem. We employ our STOCHGEN general purpose stochastic problem generator to 'recreate' the decision (scenario) tree for the unfolding future as this deterministic equivalent. To project random demands for oil products at different spatial locations into the future and to generate random fluctuations in their future prices/costs a stochastic input data ...

75

National Earth Comfort Program, Geothermal Heat Pump Market Mobilization and Technology Demonstration

The Electrochemical Technology Program at Argonne National Laboratory (ANL) provides advanced battery R D; technology transfer to industry; technical analyses, assessments, modeling, and databases; and independent testing and post-test analyses of advanced batteries. These capabilities and services are being offered to the US Advanced Battery Consortium (USABC) and Cooperative Research and Development Agreements (CRADA) are being negotiated for USABC-sponsored work at ANL. A small portion of DOE's cost share for USABC projects has been provided to ANL to continue R D and testing activities on key technologies that were previously supported directly by DOE. This report summarizes progress on these USABC projects during the period of April I through September 30, 1992. In this report, the objective, background, technical progress, and status are described for each task. The work is organized into the following task areas: 1.0 Lithium/Sulfide Batteries; 2.0 ...

1992-01-01

76

Innovation in Scholarly Communication Vision and Projects from High-Energy Physics

Late 1994, the Geothermal Heat Pump Consortium (GHPC) was launched as a non-profit collaborative effort between the United States Department of Energy, US electric utilities and the GeoExchange (geothermal heat pump) industry to make ''geothermal heat pumps'' a significant component of the HVAC industry and avoid 1.5 million metric tons of carbon equivalent per year. The goal was to create a self-sustainable GeoExchange market. This report offers a summary of some of the lessons learned and an overview of some of the programs major accomplishments.

2001-04-30

77

CERN Document Server

Having always been at the forefront of information management and open access, High-Energy Physics (HEP) proves to be an ideal test-bed for innovations in scholarly communication including new information and communication technologies. Three selected topics of scholarly communication in High-Energy Physics are presented here: A new open access business model, SCOAP3, a world-wide sponsoring consortium for peer-reviewed HEP literature; the design, development and deployment of an e-infrastructure for information management; and the emerging debate on long-term preservation, re-use and (open) access to HEP data.

2008-01-01

78

AAR in concrete of Asejire spillway (OYO state - Nigeria)

Treatment with LL-37 Peptide Enhances Antitumor Effects Induced by CpG Oligodeoxynucleotides Against Ovarian Cancer

The Asejire dam at Ibadan, Nigeria was constructed in the late sixties for the purpose of providing water for the city of Ibadan (presently about 4,5 million inhabitants). It is located on the Oshun river approximately fifteen miles from the city. In 1982 cracks were observed on the wing walls and although these continued to develop, no attempt was made at that time to investigate their causes and no repair was carried out. In 1989 the SGI ENGINEERING Group of Geneva, Switzerland was appointed as the consultant for the complete refurbishment of the Asejire water scheme. The consortium Degremont-Poat-Clemessy was awarded the contract for the project. The African Development Bank and the Nigerian Government have provided the loan to finance the project.

1995-12-31

79

Red and Processed Meat and Colorectal Cancer Incidence: Meta-Analysis of Prospective Studies

AbstractThere is an urgent need for innovative therapies against ovarian cancer, one of the leading causes of death from gynecological cancers in the United States. Immunotherapy employing...Full Text Available

2009-04-01

80

Quality-of-Life and Surgical Treatments for Rectal Cancer-a Longitudinal Analysis Using the California Cancer Registry

BackgroundThe evidence that red and processed meat influences colorectal carcinogenesis was judged convincing in the 2007 World Cancer Research Fund/American Institute of Cancer...Full Text Available

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81

Prognostic features and markers for testicular cancer management

BackgroundHeterogeneous results for research investigating health-related quality of life (HRQL) in patients undergoing sphincter-ablating procedures for rectal cancer...Full Text Available

2010-08-01

82

Preliminary Evaluation of Psychoeducational Support Interventions on Quality of Life in Rural Breast Cancer Survivors Post-Primary Treatment

Testicular neoplasm accounts for about 1% of all cancers in men. Over the last 40 years, the incidence of testicular cancer has increased in northern European male populations for unknown reasons. When...Full Text Available

2010-01-01

83

Oral cancer awareness amongst hospital nursing staff: a pilot study

While most cancer survivors are at risk for being lost in the transition from treatment to survivorship, rural breast cancer survivors face special challenges that might place them at particular...Full Text Available

2009-01-01

84

Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines

BackgroundOral cancer is as prevalent as cervical and testicular cancer in the United Kingdom. Nursing staff provide the oral health care for the patient population in hospital....Full Text Available

85

Minimally invasive surgery for rectal cancer: Are we there yet?

BackgroundThe zebrafish is recognized as a versatile cancer and drug screening model. However, it is not known whether the estrogen-responsive genes and signaling pathways that are...Full Text Available

86

Metagenes Associated with Survival in Non-Small Cell Lung Cancer

Laparoscopic colon surgery for select cancers is slowly evolving as the standard of care but minimally invasive approaches for rectal cancer have been viewed with significant skepticism. This procedure...Full Text Available

2011-02-21

87

Knowledge and Awareness about Cervical Cancer and Its Prevention amongst Interns and Nursing Staff in Tertiary Care Hospitals in Karachi, Pakistan

NSCLC (non-small cell lung cancer) comprises about 80% of all lung cancer cases worldwide. Surgery is most effective treatment for patients with early-stage disease. However, 30%–55% of these...Full Text Available

88

Immortalizing the Complexity of Cancer Metastasis Genetic Features of Lethal Metastatic Pancreatic Cancer Obtained from Rapid Autopsy

Background and ObjectiveCervical cancer is one of the leading causes of morbidity and mortality amongst the gynecological cancers worldwide, especially in developing countries. It...Full Text Available

89

High-Risk Populations Identified in Childhood Cancer Survivor Study Investigations: Implications for Risk-Based Surveillance

The virtual lack of well-characterized metastatic pancreatic cancer tissues for study has limited systematic studies of the metastatic process of this deadly disease. To address this important...Full Text Available

2005-05-01

90

Frequency of ocular metastases in patients dying of cancer in eye bank populations.

Childhood cancer survivors often experience complications related to cancer and its treatment that may adversely affect quality of life and increase the risk of premature death. The purpose of this...Full Text Available

2009-05-10

91

Fecal microRNAs as novel biomarkers for colon cancer screening

AIMS: To examine the frequency of intraocular metastases in patients who had died of cancer, in an eye bank and necropsy population sample. METHODS: The first group included 302 cancer cases received...Full Text Available

1996-02-01

92

Excessive Soft Tissue Reaction after Stereotactic Body Radiation Therapy in a Woman with Four Different Cancer Diagnoses

IntroductionColorectal cancer (CRC) is the second leading cause of cancer-related deaths, but currently available non-invasive screening programs have achieved only...Full Text Available

2010-07-01

93

Epidemiologic studies of electric and magnetic fields and cancer: strategies for extending knowledge.

Patients experiencing several cancers can be a challenge, as optimal treatment options for the different cancers might interfere with each other. In this case report, we present a woman diagnosed with...Full Text Available

94

Customizing systemic therapy in patients with advanced non-small cell lung cancer

Epidemiologic research concerning electric and magnetic fields in relation to cancer has focused on the potential etiologic roles of residential exposure on childhood cancer and occupational exposure...Full Text Available

1993-12-01

95

Current practices in spatial analysis of cancer data: data characteristics and data sources for geographic studies of cancer

Lung cancer is the leading cause of cancer deaths worldwide. Standard chemotherapy has been shown to improve quality of life and has a modest influence on overall survival. This modest improvement in...Full Text Available

2011-07-01

96

Colorectal Cancer Association of Canada consensus meeting: raising the standards of care for early-stage rectal cancer

The use of spatially referenced data in cancer studies is gaining in prominence, fueled by the development and availability of spatial analytic tools and the broadening recognition of the linkages between...Full Text Available

97

Change in HER-2/neu Status from Negative to Positive following Treatment in Breast Cancer: A Case Report

The purpose of the meeting reported here was to develop a set of national evidence-based standards for assessing and managing patients with potentially resectable rectal cancer. This report represents...Full Text Available

2009-12-01

98

Breast Cancer Stem-Like Cells Are Inhibited by a Non-Toxic Aryl Hydrocarbon Receptor Agonist

IntroductionApproximately 25–30% of breast cancers are assumed to be HER-2/neu positive. It is well known that HER-2/neu-positive cancers after treatment with trastuzumab...Full Text Available

99

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

BackgroundCancer stem cells (CSCs) have increased resistance to cancer chemotherapy. They can be enriched as drug-surviving CSCs (D-CSCs) by growth with chemotherapeutic drugs, and/or...Full Text Available

100

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer

Cancers are highly heterogeneous and contain many passenger and driver mutations. To functionally identify tumor suppressor genes relevant to human cancer, we compiled pools of short harpin...Full Text Available

2008-11-28

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101

Alcoholic Beverages and Prostate Cancer in a Prospective US Cohort Study

BackgroundGenomics has substantially changed our approach to cancer research. Gene expression profiling, for example, has been utilized to delineate subtypes of cancer, and facilitated...Full Text Available

102

Despite numerous investigations, the correlation between alcohol consumption and prostate cancer risk remains uncertain. This report investigated the association between alcohol use and prostate cancer...Full Text Available

2010-10-01

103

Acne, dairy and cancer

A DNA transposon-based approach to validate oncogenic mutations in the mouse

A potent link to dairy seems to exist for three hormone-responsive glands. Acne, breast cancer and prostate cancer have all been linked epidemiologically to dairy intake. Although mechanisms postulated...Full Text Available

2009-01-01

104

Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available

2008-12-16

105

The Tropical East Pacific as a Laboratory for Tropical Cyclones

... York, 7/15/2008) Cancers Adrenal Gland Cancer Laparoscopic Adrenalectomy (Shawnee Mission Medical Center, Shawnee Mission, KS, ... MN, 1/24/2007) Colorectal Cancer Advances in Laparoscopic Colorectal Surgery (Charles E. Schmidt College of Biomedical ...

106

Gas Storage Technology Consortium

The summertime tropical cyclogenesis rate per unit area in the eastern Pacific ocean is arguably higher than in any other location in the world. Many if not most of these cyclones form from African easterly waves which cross Central America into the Pacific. Of order 25% of these waves intensify into cyclones. A significant fraction of east Pacific tropical cyclones undergoes landfall on the Mexican coast. Those which do not, generally dissipate over cold ocean waters north of the east Pacific intertropical convergence zone, often not far from land. The layer of warm ocean water which supports the development of east Pacific cyclones is unusually shallow and is structured by anticyclonic vortices which form by various processes and propagate slowly to the west. These vortices locally deepen the oceanic mixed layer and support stronger convection than their surroundings, possibly promoting cyclogenesis and cyclone ...

2007-05-01

107

Gas Storage Technology Consortium

Gas storage is a critical element in the natural gas industry. Producers, transmission and distribution companies, marketers, and end users all benefit directly from the load balancing function of storage. The unbundling process has fundamentally changed the way storage is used and valued. As an unbundled service, the value of storage is being recovered at rates that reflect its value. Moreover, the marketplace has differentiated between various types of storage services and has increasingly rewarded flexibility, safety, and reliability. The size of the natural gas market has increased and is projected to continue to increase towards 30 trillion cubic feet over the next 10 to 15 years. Much of this increase is projected to come from electric generation, particularly peaking units. Gas storage, particularly the flexible services that are most suited to electric loads, is crucial in meeting the needs of these new markets. To address the gas storage needs of the natural gas industry, an ...

2007-06-30

108

Toward a theory of the initiation of cancer by ionizing radiation: the twin doublet pair model

The EMS Energy Institute at The Pennsylvania State University (Penn State) has managed the Gas Storage Technology Consortium (GSTC) since its inception in 2003. The GSTC infrastructure provided a means to accomplish industry-driven research and development designed to enhance the operational flexibility and deliverability of the nation's gas storage system, and provide a cost-effective, safe, and reliable supply of natural gas to meet domestic demand. The GSTC received base funding from the U.S. Department of Energy's (DOE) National Energy Technology Laboratory (NETL) Oil & Natural Gas Supply Program. The GSTC base funds were highly leveraged with industry funding for individual projects. Since its inception, the GSTC has engaged 67 members. The GSTC membership base was diverse, coming from 19 states, the District of Columbia, and Canada. The membership was comprised of natural gas storage field operators, service companies, industry ...

2010-09-30

109

The Challenges of Colorectal Cancer Survivorship

Models are proposed which explain the mechanism of action on a molecular level for the initiation of cancer by electrons or alpha particles. (ACR)

1980-01-01

110

Role of Positron Emission Mammography (PEM) Flex Solo II Positron Emission Tomography (PET) Scanner in Evaluating Neoadjuvant Chemotherapy Response in Patients With Breast Cancer

With advances in treatment, colorectal cancer is being transformed from a deadly disease to an illness that is increasingly curable. With this transformation has come increased interest in the...Full Text Available

2009-09-01

111

Role of Obesity in Prostate Cancer Development

Breast Cancer

2011-06-14

112

Reducing the Cancer Burden of Lifestyle Factors: Opportunities and Challenges of the Internet

... estrogen receptor status. Cancer Lett., 253, 291-300. 39. Xin,X ... and resistant mice. Brain Res.Bull., 52, 235-242. 40. Foster,BA ...

2011-04-01

113

Prognostic Indicators of Surgery for Esophageal Cancer: A 5 Year Experience

This paper focuses on the Internet as a tool for enhancing behavior and lifestyle changes to reduce the burden of cancer at a population level. The premise of this paper is that the Internet...Full Text Available

114

Localised breast cancers may have systemic influences on skin and hair

Background/Aim:To assess the prognostic indicators preoperatively presenting and influencing the mortality rate following esophagectomy for esophageal cancer.Full Text Available

2010-10-01

115

Laparoscopic surgery for rectal cancer: The state of the art

HypothesisBiomarkers, commonly expressed in breast cancer cells, may be correlated with their expression in breast skin of the same subjects.MethodsThe...Full Text Available

2007-02-01

116

Humoral BMP-2 is Sufficient for Inducing Breast Cancer Microcalcification

At present time, there is evidence from randomized controlled studies of the success of laparoscopic resection for the treatment of colon cancer with reported smaller incisions, lower morbidity rate...Full Text Available

2010-09-27

117

EFFECT OF ANATOMIC MOTION ON PROTON THERAPY DOSE DISTRIBUTIONS IN PROSTATE CANCER TREATMENT

Microcalcifications are an important diagnostic marker for breast cancer on mammograms, yet the mechanism of their formation is poorly understood. Indeed, there is presently no short-latency,...Full Text Available

2008-01-01

118

Dietary Lipids, Cells Adhesion and Breast Cancer Metastasis

PurposeTo determine the dosimetric impact of inter-fraction anatomical movements in prostate cancer patients receiving proton therapy.Full Text Available

2007-02-01

119

Diabetes and risk of incident colorectal cancer in a prospective cohort of women

... Accession Number : ADA396364. Title : Dietary Lipids, Cells Adhesion and Breast Cancer Metastasis. Descriptive Note : Annual rept. ...

2000-10-01

120

DNA Hypermethylation Patterns Detected in Serum as a Tool ...

ObjectiveTo determine whether accounting for the time dynamics of diabetes exposure will change the risk estimates for colorectal cancer.Full Text Available

2010-08-01

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121

Content analysis of cancer blog posts*

... Grant support: National Cancer Institute Center grant CA 16087 and National Cancer Institute grant CA091892, Department of Defense grant ...

2009-09-01

122

Cancer cells cause vascular endothelial cell (vEC) retraction via 12(S)HETE secretion; the possible role of cancer cell derived microparticle.

Objectives:The efficacy of user-defined subject tagging and software-generated subject tagging for describing and organizing cancer blog contents was explored.Methods:The...Full Text Available

2009-10-01

123

Cancer as a metabolic disease

PMID:17103063

2006-11-12

124

Cancer Patients' Self-Reported Attitudes About the Internet

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which...Full Text Available

125

CDC - Cancer - NPCR - Registry Plus(tm) Software Programs for...

Background Increasing numbers of cancer patients are using the Internet, but little is known about their attitudes toward online health care.Full Text Available

126

CDC - Cancer - NPCR - NPCR-EDITS Technical Support

Malignancies Breast Malignancies Bladder, Prostate, and Testicular Malignancies Uses of Cancer Registry Data Brain Tumor Reporting Training Materials Overview Presentation and...

2011-10-15

127

CDC - Cancer - NPCR - NPCR-EDITS Downloads

Malignancies Breast Malignancies Bladder, Prostate, and Testicular Malignancies Uses of Cancer Registry Data Brain Tumor Reporting Training Materials Overview Presentation and...

2011-10-15

128

Breast cancer in the elderly.

Malignancies Breast Malignancies Bladder, Prostate, and Testicular Malignancies Uses of Cancer Registry Data Brain Tumor Reporting Training Materials Overview Presentation and...

2011-10-15

129

Anxiety and Cancer Treatment: Response to Stressful Radiotherapy

Breast cancer in the elderly has attracted considerable interest in recent years for three main reasons. Firstly, information concerning the profile (clinical and biological) of the disease in the geriatric...Full Text Available

1995-11-01

130

Adaptive Radiation for Lung Cancer

Previous research with individuals undergoing surgery or diagnostic procedures provided a conceptual framework for analysis of radiation therapy, a common form of cancer treatment. The present...Full Text Available

1984-01-01

131

Adaptive Management of Liver Cancer Radiotherapy

The challenges of lung cancer radiotherapy are intra/inter-fraction tumor/organ anatomy/motion changes and the need to spare surrounding critical structures. Evolving radiotherapy technologies, such...Full Text Available

2011-01-01

132

Abnormal chromosome repair and risk of developing cancer.

Adaptive radiation therapy for liver cancer has the potential to reduce normal tissue complications and enable dose escalation, allowing the potential for tumor control in this challenging site....Full Text Available

2010-04-01

133

A Dose- and Time-Controllable Syngeneic Animal Model of Breast Cancer Microcalcification

Several scientists have proposed that DNA repair deficiencies and the induction of a mutator phenotype are responsible for the generation of multiple mutagenic alterations in cancer cells. I propose...Full Text Available

1993-10-01

134

The Global Health Initiative: The Next Phase of American Leadership

IntroductionThe development of novel diagnostic agents for the detection of breast cancer microcalcifications requires a reliable animal model. Based on previous...Full Text Available

2010-07-01

135

Temporal Correlations between Tick Abundance and Prevalence of Ticks Infected with Borrelia burgdorferi and Increasing Incidence of Lyme Disease

Issues Democracy and Human Rights Economic Issues Energy Security Food Security Haiti Health Iran Iraq Landmines Middle East Muslim Outreach Narcotics Nonproliferation North Korea...

2011-08-28

136

Review of the genus Hartemita Cameron, 1910 (Hymenoptera, Braconidae, Cardiochilinae), with the description of six new species from Vietnam

The abundance of host-seeking Ixodes scapularis nymphs, the principal vector for the Lyme disease agent, Borrelia burgdorferi, in Old Lyme, Lyme, and East Haddam, Connecticut,...Full Text Available

1998-05-01

137

Phylogenetic and Evolutionary Relationships among Yellow Fever Virus Isolates in Africa

AbstractThe Oriental and East Palaearctic genus Hartemita Cameron, 1910 (Braconidae: Cardiochilinae) is recorded...Full Text Available

138

Molecular DNA Systematic Analyses of East Asian Mammals: Sequence Variation of Cytochrome b Gene and Control Region of Mitochondrial DNA of Common Otter, Lutra lutra lutra L. (Mammalia, Carnivora) from Korea

Previous studies with a limited number of strains have indicated that there are two genotypes of yellow fever (YF) virus in Africa, one in west Africa and the other in east and central Africa. We have...Full Text Available

2001-08-01

139

Massive encapsulation of larval Anguillicoloides crassus in the intestinal wall of Japanese eels

Full Text Available

2004-09-01

140

Landscape determinants and remote sensing of anopheline mosquito larval habitats in the western Kenya highlands

BackgroundWithin the last 25 years, after the introduction of the swimbladder nematode Anguillicoloides crassus from East-Asia to Europe, a body of work has aggregated...Full Text Available

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141

Cytoprotective Activity of Glycyrrhizae radix Extract Against Arsenite-induced Cytotoxicity

BackgroundIn the past two decades the east African highlands have experienced several major malaria epidemics. Currently there is a renewed interest in exploring the possibility...Full Text Available

142

Clouded leopards, the secretive top-carnivore of South-East Asian rainforests: their distribution, status and conservation needs in Sabah, Malaysia

Licorice, Glycyrrhizae radix, is one of the herbal medicines in East Asia that has been commonly used for treating various diseases, including stomach disorders. This study investigated...Full Text Available

2008-06-01

143

An assessment of the effects on seabirds of a possible oil exploration at the shelf outside Central Norway out to 1"o East

BackgroundThe continued depletion of tropical rainforests and fragmentation of natural habitats has led to significant ecological changes which place most top carnivores under heavy...Full Text Available

144

Vocational rehabilitation services for patients with cancer: design of a feasibility study incorporating a pilot randomised controlled trial among women with breast cancer following surgery

This report gives the results of an assessment of the effects on seabirds of possible petroleum exploration at the shelf outside Central-Norway out to 1"o East. By combining oil spill simulations with the valued ecosystem components, i.e. seabirds, their distribution, and their vulnerability indexes, the relative index values for the direct effects of oil spills were calculated. For the purpose, the analysis system SIMPACT was used. On the basis of these results and other relevant considerations, recommendations for limiting a possible drilling activity are given. 85 refs., 49 figs., 9 tabs.

2002-09-01

145

Usefulness of High-B-value Diffusion - Weighted MR Imaging for the Pre-operative Detection of Rectal Cancers

BackgroundDue to improvements in cancer survival the number of people of working age living with cancer across Europe is likely to increase. UK governments have made commitments...Full Text Available

146

Road to Recovery from Prostate Cancer

Full Text Available

2009-12-01

147

... have the support of the hospital, from the CEO to administration, to the chief of urology that ...

148

Ovarian Cancer

Occult brain metastases in HER2-positive breast cancer patients: Frequency and response to radiotherapy

... opening the abdomen surgically. This surgery may be laparoscopic, using special scopes. It could also be an ...

149

No difference in antibody titers against xenotropic MLV related virus in prostate cancer cases and cancer-free controls

No abstract prepared.

2007-10-15

150

British Library Electronic Table of Contents (United Kingdom)

New ELISA assays were developed to measure immunoreactivity for XMRV. Antibody titers were measured in a cohort of prostate cancer cases and cancer free controls from the central United States. No statistically significant differences were observed in immunoreactivity between cases and controls for either the XMRV-env or the XMRV-gag antigen.

2011-01-01

151

Intrathecal Catheter and Subcutaneous Access Port Implantation in Pain Management for Terminal Cancer Patient - A case report -

Hypodiploidy, Ki-67 growth fraction and prognosis of surgically resected lung cancers.

Full Text Available

2007-12-01

152

High grade prostatic intraepithelial neoplasia in military workingn> dogs with and without prostate cancer.

One hundred and thirty-seven lung cancer patients (123 non-small-cell lung cancers (NSCLC), 10 small-cell lung cancers (SCLC) and four carcinoid tumours) who underwent surgery in an attempt at complete...Full Text Available

1996-09-01

153

G2 checkpoint siRNA screen in irradiated cancer cells: validation of candidate positive hits

PMID:9687991

1998-08-01

154

Norwegian Open Research Archives (NORA)

Full Text Available

155

DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis

DEFF Research Database (Denmark)

Udgivelsesdato: 2008-May

2008-01-01

156

Clinical Usefulness of Implanted Fiducial Markers for Hypofractionated Radiotherapy of Prostate Cancer

Clinical Experience of 3T Breast MRI in Detecting the Additional Lesions in Breast Cancer Patients

Full Text Available

2011-06-01

157

Capsaicin induced apoptosis and the enhanced anticancer effect of anticancer drugs in cancer cells

Full Text Available

2010-12-01

158

Assesment of guardian node in breast cancer

Full Text Available

2008-03-01

159

Antiproliferation Effects of Germinated-Korean Rough Rice Extract on Human Cancer Cells

2004 p. 32 Poland Jastrzebski, T. Klinika Chirurgii Onkologicznej, Akademia

160

Permian and Triassic geological history and tectonics of the Middle East

Full Text Available

2010-03-01

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161

Performance assessment for the disposal of low-level waste in the 200 east area burial grounds

The paleogeography postulated from the distribution of Permian and Triassic sedimentary rocks in the Middle East is shown and related to the paleostructure of the region. The Middle East region as defined here includes the Arabian Peninsula, Iran, Iraq, SE Turkey, Syria, Lebanon, Jordan, West Jordan, and the Sinai Peninsula. Within the limits of the area included in this study, a relatively stable pre-Late Triassic tectonic regime can be recognized and distinguished from a succession of diastrophic events of the Late Triassic epoch, which caused marked changes in the types and distribution of facies. Excluding NE Iran, the Middle East was stable from Late Cambrian to Middle Triassic times, as it formed a part of the Arabian Massif and much of the Middle East Platform, which is a broad shelf bordering the positive Afro-Arabian Massif to the NE and east. The sediments of this platform ...

1983-07-01

162

Human papillomavirus: science and technologies for the elimination of cervical cancer

A performance assessment analysis was completed for the 200 East Area Low-Level Burial Grounds (LLBG) to satisfy compliance requirements in DOE Order 5820.2A. In the analysis, scenarios of radionuclide release from the 200 East Area Low-Level waste facility was evaluated. The analysis focused on two primary scenarios leading to exposure. The first was inadvertent intrusion. In this scenario, it was assumed that institutional control of the site and knowledge of the disposal facility has been lost. Waste is subsequently exhumed and dose from exposure is received. The second scenario was groundwater contamination.In this scenario, radionuclides are leached from the waste by infiltrating precipitation and transported through the soil column to the underlying unconfined aquifer. The contaminated water is pumped from a well 100 m downstream and consumed,causing dose. Estimates of potential contamination of the surrounding environment were developed ...

1996-08-15

163

British Library Electronic Table of Contents (United Kingdom)

Introduction: Academic research has made a significant advancement in understanding the viral causes of cervical cancer and generating the technology for prevention, both at the primary and secondary levels. Human papillomaviruses (HPVs) have been recognized as the first necessary cause of cervical cancer, the second most common cancer in women worldwide. Areas covered: This paper reviews the epidemiological evidence of the causality of HPV in relation to cervical cancer, other genital tract cancers and some cancers of the oral cavity and oropharynx. The review also covers HPV DNA testing as a screening tool. DNA probes of high-risk HPV types in different formats have been fully validated as primary screening tests, as secondary triage tests and as a prognostic marker following treatment o...

2011-01-01

164

BUBL LINK: Skin cancer

Lithium/polymer batteries. Safety approach of the BT-EDF-CEA project; Accumulateurs lithium/polymere. Demarche securite du projet BT-EDF-CEA

...CanCom Dermatology Image Bank Dermatology Online Atlas Introduction to Skin Cancer Malignant Melanoma Skin Cancer (Not Melanoma) Comments: bubl@bubl.ac.... Covers anatomy, melanoma, infections, and dermatological disorders in AIDS. Author: University of Utah ...994 Resource type: document Malignant Melanoma This leaflet on malignant melanoma covers early detection, causes, clinical signs and symptoms, and provides ...9 Resource type: document Skin Cancer (Not Melanoma) Information on basal cell and squamous cell skin cancers. Author: ...

165

Bioconversion of chicken wastes to value-added products

The BT-EdF-CEA consortium for the development and the performance improvement of lithium/polymer batteries has carried out a safety analysis of the industrial risk and the risk for users linked with this new technology. The process chosen for the manufacturing of lithium/polymer batteries does not generate any particular risk of personnel or environmental contamination. Security tests have permitted to observe and analyze the behaviour of 4 Ah elements during thermal shocks, perforation and crushing, and during external short-circuit on 20 Ah elements. These tests demonstrate the great thermal stability and the excellent behaviour of batteries in the case of partial destruction. (J.S.) 2 refs.

1996-12-31

166

An overview of field-specific designs of microbial EOR

Increasing quantities of chicken waste concerns the poultry industry because of escalating disposal costs and the potential for environmental pollution. Biological conversion of these wastes to valuable products such as methane and/or chemical feed-stocks appears to be feasible. Biomethanation of chicken waste by a sewage sludge microbial consortium produced as much as 69 mol% methane in the gas phase. Acetic and propionic acids were the major acids produced during the bioconversion. Addition of chelating agents and other micro-nutrients enhanced methane production and shifted the ratios of intermediates accumulated. Preliminary data indicate that more than 60% of the chicken waste carbon was converted and that the nitrogen-rich residue may have potential as a soil additive. (author).

1991-01-01

167

Advances in feedstock recycling offer help with plastic waste

The selection and design of an MEOR process for application in a specific field involves geological, reservoir, and biological characterization. Microbially mediated oil recovery mechanisms (bigenic gas, biopolymers, and biosurfactants) are defined by the types of microorganisms used. The engineering and biological character of a given reservoir must be understood to correctly select a microbial system to enhance oil recovery. This paper discusses the methods used to evaluate three fields with distinct characteristics and production problems for the applicability of MEOR would not be applicable in two of the three fields considered. The development of a microbial oil recovery process for the third field appeared promising. Development of a bacterial consortium capable of producing the desired metabolites was initiated, and field isolates were characterized.

1995-12-31

168

Identification of prostate cancer antigens by automated high-throughput filter immunoscreening

An idea whose time has come takes center stage in London this week when BP Chemicals announces details of a consortium of chemical companies joining it in a new recycling project. In the project, which BP has been working on since 1989, waste plastic will be depolymerized to chemical feedstocks, via technology variously called feedstock or chemical recycling, polymer cracking, or tertiary recycling. BP's effort is one of the first to emerge from the research and pilot-plant stages that are committed to actual feedstock recycling of mixed polyolefins and other plastics. But it is only one of the many industry efforts under way to cope with the job of dealing with postconsumer plastics.

1993-10-04

169

British Library Electronic Table of Contents (United Kingdom)

There is a need for earlier and more accurate cancer diagnostics as well as new targets for cancer immunotherapy. To this end, it is important to identify sets of tumour antigens specific for different cancer forms. Several methods that identify potential tumour antigens in an arrayed and high-throughput format have been developed during the last years of SEREX (serological identification of antigens by recombinant expression cloning) related research. Such techniques may hold the potential to describe the complete immunogenic part of the cancer proteome, also called the cancer immunoproteome.We have developed a powerful platform for automated serological high-throughput filter screening of tumour cDNA libraries. The screening format of this method is 18,000 single cDNAs clones, which is s...

2008-01-01

170

Green Tea Extract (Epigallocatechin-3-Gallate) Reduces Efficacy of Radiotherapy on Prostate Cancer Cells

British Library Electronic Table of Contents (United Kingdom)

ObjectivesTo assess the influence of epigallocatechin-3-gallate (EGCG) on the efficacy of ionizing radiation on prostate cancer cells because of the increased use of dietary interventions, especially by patients with prostate cancer. Radiotherapy is used to treat localized prostate cancer. Some people consume green tea (EGCG) as a chemopreventive agent against prostate cancer. Green tea can act as an antioxidant and induce superoxide dismutase enzymes, which could scavenge the free oxygen radicals generated by radiotherapy. MethodsProstate cancer cell line DU145 cells were treated with EGCG or radiotherapy, or both. Cell death was assessed using trypan blue cell counting, and apoptosis was confirmed by assessing poly (adenosine phosphate ribose) polymerase cleavage. The antioxidant potenti...

2011-01-01

171

Epidemiological studies concerned with exposure to extremely low frequency electromagnetic fields and the risk of cancer

Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study

Extensive epidemiological studies have been carried out in recent years to examine the possible effects of exposure to extremely low frequency electromagnetic fields on the development of cancer. In some studies, both residential and occupational, a number of cancers, in particular leukaemia and brain cancer, have occurred at an increased incidence at higher levels of exposure. In general, however, no consistent and coherent pattern of results has been obtained and no clear evidence of a cancer risk has been demonstrated. A better understanding of any effect of electromagnetic fields on the development of cancer must await the results of more informative epidemiological studies and an improved understanding of the mechanisms by which these fields may interact with the body and their likely consequences. (author)

1997-12-01

172

British Library Electronic Table of Contents (United Kingdom)

Background Despite potentially relevant chemical differences between filtered and boiled coffee, this study is the first to investigate consumption in relation to the risk of incident cancer. Methods Subjects were from the V?sterbotten Intervention Project (64,603 participants, including 3,034 cases), with up to 15?years of follow-up. Hazard ratios (HR) were calculated by multivariate Cox regression. Results No associations were found for all cancer sites combined, or for prostate or colorectal cancer. For breast cancer, boiled coffee ?4 versus <1 occasions/day was associated with a reduced risk (HR?=?0.52, CI?=?0.30?0.88, p trend?=?0.247). An increased risk of premenopausal and a reduced risk of postmenopausal breast cancer were found for both total (HRpremenopausal?=?1.69, CI?=?0.96?2.98...

2010-01-01

173

Association of brain cancer with dental x-rays and occupation in Missouri

Palynostratigraphy and palaeoenvironment of the Middle Jurassic Sortehat Formation (Neill Klinter Group), Jameson Land, East Greenland

This investigation of a brain cancer cluster in Missouri used two approaches to investigate associations with potential risk factors. In a case-control study in a rural town, we interviewed surrogates of cases and controls about potential risk factors. We found a statistically significant positive association of brain cancer with reported exposure to dental x-rays. Occupation was not associated with the cluster in the rural town. In a standardized proportional mortality study for the state of Missouri, we calculated the observed and expected proportion of brain cancers by occupation and industry in Missouri decedents. We found that motor vehicle manufacturers, beauty shop workers, managers and administrators, elementary school teachers, and hairdressers and cosmetologists had significantly elevated proportions of brain cancer. Brain tumors are inconsistently associated with occupation in the literature. ...

1991-01-01

174

Measurement results of BHTV logging at the geothermal well. 1; Chinetsusei ni okeru BHTV kenso no sokutei kekka. 1

The grey-black mudstones of the Sonehat Formation form part of the Middle Jurassic fill of the Jameson Land Basin in East Greenland. The formation is exposed in the southernmost part of the north south-trending, Mesozoic rift system in East Greenland that was part of the epeiric seaway betaveen East Greenland and Norway. Sedimentological observations of the Sortehat Formation indicate deposition in an offshore marine setting that was typically low energy and periodically oxygen-deficient but was influenced by storm currents on occasion. Detailed palynological studies of the Sortehat Formation have resulted in the definition of theee palynological assemblage zones recognised at four localities, namely Enhjoerningen Dal and Pelion (north Jameson Land), the type section at Sortehat (central Jameson Land) and Albuen at Neill Klinter along Hurry Inlet (south-east Jameson Land). In stratigraphic order, these ...

2003-07-01

175

X-Ray Phase Imaging for Breast Cancer Detection

In association with excavation of the No. 135 steam producing well in the Onikubi geothermal power plant in Miyagi Prefecture, shapes of production zones and drilling-induced fracture (DIF) were acquired from the borehole televiewer (BHTV) data. The BHTV logging shoots sound waves onto well walls of wells filled with fluid and detects the reflection waves to investigate the state of the well walls. Vertical fracture with opening lengths from 2 to 3 m were found at depths of about 1232 m and 1312 m. Water run-off has occurred at a depth of about 1312 m during the excavation, to which these vertical fractures might have contributed possibly. In depths of about 1232 m and 1312 m, fractures inclining toward north-east direction and south-west direction are predominant. Some fractures in the depth of about 1333 m incline toward east-south-east direction and west-north-west direction. Fracture inclination azimuth in all of the present logging ...

1997-05-27

176

Whole-genome cancer analysis as an approach to deeper understanding of tumour biology

... Accession Number : ADA535309. Title : X-Ray Phase Imaging for Breast Cancer Detection. Descriptive Note : Annual rept. 1 Sep 2009-31 Aug 2010 ...

2010-09-01

177

Whipple Procedure for Pancreatic Cancer

Recent advances in DNA sequencing technology are providing unprecedented opportunities for comprehensive analysis of cancer genomes, exomes, transcriptomes, as well as epigenomic components. The integration...Full Text Available

2010-01-19

178

Voiding and Sexual Function after Autonomic-Nerve-Preserving Surgery for Rectal Cancer in Disease-Free Male Patients

... be able to watch the many intricate steps Dr. Richard Alexander must accomplish to remove the cancer. ... door to informed medical care. Now let's join Dr. Richard Alexander at the University of Maryland Medical ...

179

Variants in Inflammation Genes and the Risk of Biliary Tract Cancers and Stones: A Population-based Study in China

PurposeWe evaluated the effects of surgery for rectal cancer on postoperative voiding and sexual function over the course of time.Materials and MethodsData...Full Text Available

2010-12-01

180

Urinary symptoms and impact on quality of life in women after treatment for endometrial cancer

To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), including...Full Text Available

2008-08-01

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181

Tumor-derived extracellular mutations of PTPRT/PTP? are deficient in cell adhesion

The primary objective of our study is to describe urinary symptoms in women treated for endometrial cancer. We performed a cross-sectional survey of women who had undergone surgical treatment...Full Text Available

2009-02-01

182

Tumor-Endothelial Interaction Links the CD44⁺/CD24^- Phenotype with Poor Prognosis in Early-Stage Breast Cancer1

Receptor protein tyrosine phosphatase T (PTPRT/PTPρ) is frequently mutated in human cancers including colon, lung, gastric and skin cancers. More than half of the identified tumor-derived...Full Text Available

2008-07-01

183

Transposons for cancer gene discovery: Sleeping Beauty and beyond

Materials and MethodsThe genomic effects of tumor-endothelial interactions in cancer are not yet well characterized. To study this interaction in breast...Full Text Available

2009-10-01

184

Transposon-based screens for cancer gene discovery in mouse models

The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping...Full Text Available

2007-01-01

185

Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo

Significant emphasis has recently been placed on the characterization of the human cancer genome. This effort has been assisted by the development of new DNA sequencing technologies that allow...Full Text Available

2010-08-01

186

Therapy of Primary Breast Cancer

BackgroundThymoquinone (TQ) is a compound extracted from Black Caraway seeds of Nigella Sativa and is active against various cancers. Cisplatin (CDDP) is the most...Full Text Available

187

The workplace: Monitoring and prevention of occupational hazards. Volume 4

Most breast cancers are multicentric in origin. They drain into two primary lymphatic depots—the axilla and internal mammary chain of nodes. The incidence of metastasis to the internal mammary...Full Text Available

1970-04-01

188

The Perceived Care Needs of Breast Cancer Patients in Korea

This book examines the occupational health hazards imposed by neoplasms. Topics considered include: cancer as an occupational hazard; an overview; epidemiological evidence; and interaction of host and lifestyle factors with occupational chemicals in cancer causation.

1985-01-01

189

The Abandoned Radical Hysterectomy for Cervical Cancer: Clinical Predictors and Outcomes

By analyzing the data of 459 patients who completed the Supportive Care Needs Survey (SCNS), the prevalence, medical and non-medical predictors of unmet needs were investigated. Breast cancer patients...Full Text Available

2006-08-31

190

Targeting Prostate Cancer Cells In Vivo Using a Rapidly Internalizing Novel Human Single-Chain Antibody Fragment

Objective. Cervical cancer patients who had an abandoned radical hysterectomy were evaluated for preoperative clinical predictors, complication rates, and outcomes. Study...Full Text Available

2010-01-01

191

TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell Lines

Human antibodies targeting prostate cancer cell surface epitopes may be useful for imaging and therapy. The objective of this study was to evaluate the tumor targeting of an internalizing human...Full Text Available

2010-03-01

192

T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells

Recent studies suggest that TJ-41, a herbal drug, possesses chemotherapeutic effects. Accordingly, this study was undertaken to investigate the anticarcinogenic effects of TJ-41 on human breast cancer...Full Text Available

2009-01-01

193

Surveillance for the detection of early lung cancer in patients with bronchial dysplasia

Epidermal growth factor receptor (EGFR)-specific monoclonal antibodies predominantly inhibit colorectal cancer (CRC) growth by interfering with receptor signaling. Recent analyses have shown that patients...Full Text Available

2010-07-13

194

Sphincter preservation for distal rectal cancer - a goal worth achieving at all costs?

BackgroundThe natural history of bronchial preinvasive lesions and the risk of developing lung cancer in patients with these lesions are not clear. Previous studies have treated...Full Text Available

2007-01-01

195

Smoking cessation and lung cancer risk in an Asian population: Findings from the Singapore Chinese Health Study

To assess the merits of currently available treatment options in the management of patients with low rectal cancer, a review of the medical literature pertaining to the operative and non-operative management...Full Text Available

2011-02-21

196

Skin Cancer in Skin of Color

Background:Smoking cessation is an important strategy for reducing the harmful effects of tobacco, particularly in the prevention of lung cancer; however, prospective data on the...Full Text Available

2010-09-28

197

SirT1 brings stemness closer to cancer and aging

Skin cancers in skin of color often present atypically or with advanced stage in comparison to Caucasian patients. Health care providers must maintain a high index of suspicion when examining...Full Text Available

2009-01-01

198

Serum HER2 Level Measured by Dot Blot: A Valid and Inexpensive Assay for Monitoring Breast Cancer Progression

Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of...Full Text Available

199

Sequential Molecular and Cellular Events during Neoplastic Progression: A Mouse Syngeneic Ovarian Cancer Model1

Human epidermal growth factor receptor 2 (HER2) is one of the most important prognostic and predictive factors for breast cancer patients. Recently, serum HER2...Full Text Available

200

Second primary cancers of the breast: incidence and risk factors.

AbstractStudies performed to identify early events of ovarian cancer and to establish molecular markers to support early detection and development of chemopreventive regimens have been...Full Text Available

2005-10-01

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201

Romantic and Sexual Relationships, Body Image, and Fertility in Adolescent and Young Adult Testicular Cancer Survivors: A Review of the Literature

Between 1946 and 1976 over 9,000 women with breast cancer were seen within one year of diagnosis at the A. Maxwell Evans Clinic (AMEC) in Vancouver, British Columbia. By 1978, 275 had a subsequent diagnosis...Full Text Available

1984-01-01

202

Role of Estrogen Receptor-? in the Regulation of Claudin-6 Expression in Breast Cancer Cells

This review presents a summary of existing knowledge regarding the impact of testicular cancer along four broad domains, including romantic and sexual relationships, body image, and fertility....Full Text Available

2010-08-01

203

Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries

PurposeIn our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration-...Full Text Available

2011-03-01

204

Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

Objectives To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental,...Full Text Available

2005-07-09

205

Relevance of circulating nucleosomes and oncological biomarkers for predicting response to transarterial chemoembolization therapy in liver cancer patients

Background:Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear.Methods:We examined...Full Text Available

2010-03-30

206

Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer

BackgroundTransarterial chemoembolization (TACE) therapy is an effective locoregional treatment in hepatocellular cancer (HCC) patients. For early modification of therapy, markers...Full Text Available

207

Radical Resection After IORT-Containing Multimodality Treatment is the Most Important Determinant for Outcome in Patients Treated for Locally Recurrent Rectal Cancer

Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor...Full Text Available

208

Quality of life in patients with head and neck cancers.

BackgroundThe optimal treatment for locally recurrent rectal cancer (LRRC) is still a matter of debate. This study assessed the outcome of LRRC patients treated with multimodality...Full Text Available

2008-07-01

209

Quality of life in patients with esophageal stenting for the palliation of malignant dysphagia

OBJECTIVE: The aim was to assess the psychosocial effects on the quality of life (QOL) of adults with head and neck cancer (HNC) and any gender variations with predictive factors that may influence...Full Text Available

2006-05-01

210

Putative Biomarkers and Targets of Estrogen Receptor Negative Human Breast Cancer

Incidence of esophageal cancer (EC) is rising more rapidly in the Western world than that of any other cancer. Despite advances in therapy, more than 50% of patients have incurable disease at the time...Full Text Available

2011-01-14

211

Protocadherin-PC Promotes Androgen-Independent Prostate Cancer Cell Growth

Breast cancer is a progressive and potentially fatal disease that affects women of all ages. Like all progressive diseases, early and reliable diagnosis is the key for successful treatment and annihilation....Full Text Available

212

Proteomic patterns analysis with multivariate calculations as a promising tool for prompt differentiation of early stage lung tissue with cancer and unchanged tissue material

BACKGROUNDProtocadherin-PC (PCDH-PC) expression is upregulated in apoptosis-resistant sublines of the LNCaP human prostate cancer (CaP) cell line. Here, we assess...Full Text Available

2006-07-01

213

Proteome of human colon cancer stem cells: A comparative analysis

BackgroundLung cancer diagnosis in tissue material with commonly used histological techniques is sometimes inconvenient and in a number of cases leads to ambiguous conclusions. Frequently...Full Text Available

214

Protein expression based multimarker analysis of breast cancer samples

AIM: To isolate and identify the biological characteristics of human colon cancer stem cells (SW1116 cells) and further study their proteome.METHODS: SW1116 cells were isolated and cultured with...Full Text Available

2011-03-14

215

Prognostic Significance of Peritumoral Lymphatic Vessel Density and Vascular Endothelial Growth Factor Receptor 3 in Invasive Squamous Cell Cervical Cancer

BackgroundTissue microarray (TMA) data are commonly used to validate the prognostic accuracy of tumor markers. For example, breast cancer TMA data have led to the identification...Full Text Available

216

Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts

Cervical cancer is known to metastasize primarily by the lymphatic system. Dissemination through lymphatic vessels represents an early step in regional tumor progression, and the presence of lymphatic...Full Text Available

217

Phytoestrogens: epidemiology and a possible role in cancer protection.

BackgroundIdentification of urinary biomarkers for detection of bladder cancer recurrence would be beneficial to minimize the frequency of cystoscopy. Our objective was to determine...Full Text Available

218

Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

Because many diseases of the Western Hemisphere are hormone-dependent cancers, we have postulated that the Western diet, compared to a vegetarian or semivegetarian diet, may alter hormone production,...Full Text Available

1995-10-01

219

Pancreatic cancer: molecular pathogenesis and new therapeutic targets

During the past decade elevated phospholipase D (PLD) activity has been reported in virtually all cancers where it has been examined. PLD catalyzes the hydrolysis of phosphatidylcholine to generate...Full Text Available

2009-09-01

220

PLESIOTHERAPY FOR NON-MELANOMA SKIN CANCER: INNOVATING TO OVERCOME!

Patients with pancreatic cancer normally present with advanced disease that is lethal and notoriously difficult to treat. Survival has not improved dramatically, despite routine use of chemotherapy...Full Text Available

2009-07-01

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221

Ovarian cancer mouse models: a summary of current models and their limitations

Background:The non-surgical management of non-melanoma skin cancers is an area requiring clinical investigation. Radiotherapy has a role in treatment for a defined subset...Full Text Available

2010-10-01

222

Oligomycin-induced Bioenergetic Adaptation in Cancer Cells with Heterogeneous Bioenergetic Organization

Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different...Full Text Available

223

Nucleoside Drugs Induce Cellular Differentiation by Caspase-Dependent Degradation of Stem Cell Factors

Cancer cells constantly adapt to oxidative phosphorylation (OXPHOS) suppression resulting from hypoxia or mitochondria defects. Under the OXPHOS suppression, AMP-activated protein kinase (AMPK) regulates...Full Text Available

2010-04-23

224

Nuclear ? catenin as a potential prognostic and diagnostic marker in patients with colorectal cancer from Hong Kong

BackgroundStem cell characteristics are an important feature of human cancer cells and play a major role in the therapy resistance of tumours. Strategies to target cancer stem cells...Full Text Available

225

Nonbacterial thrombotic endocarditis associated with cancer of unknown origin complicated with thrombus in the left auricular appendage: case report

Aims: To study the expression of nuclear β catenin in patients with colorectal cancer, colorectal adenoma, and colorectal polyps to elucidate its role in carcinogenesis, and its...Full Text Available

2003-12-01

226

Neoadjuvant vs adjuvant pelvic radiotherapy for locally advanced rectal cancer: Which is superior?

A 63-year-old man was admitted to our hospital with a complaint of right lateroabdominal pain. He was diagnosed with metastatic colon cancer, and then developed multiple brain embolic infarctions 7...Full Text Available

227

Nanochemoprevention: Sustained Release of Bioactive Food Components for Cancer Prevention

The treatment of locally advanced rectal cancer including timing and dosage of radiotherapy, degree of sphincter preservation with neoadjuvant radiotherapy, and short and long term effects of radiotherapy...Full Text Available

2011-02-21

228

Morbidity using subcutaneous ports and efficacy of vancomycin flushing in cancer.

Chemoprevention, especially through the use of naturally occurring phytochemicals capable of impeding the process of carcinogenesis at one or more steps, is an ideal approach for cancer management....Full Text Available

2010-10-01

229

Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines

An evaluation of totally implanted venous access systems inserted in 163 consecutive children with cancer is reported. From 1988 to 1994, 180 subcutaneous ports were inserted in children more than 1...Full Text Available

1995-04-01

230

Massachusetts' approach to the prevention of heart disease, cancer, and stroke.

BackgroundCD26 (dipeptidyl peptidase IV, DPPIV) is a 110 kDa surface glycoprotein expressed in most normal tissues, and is a potential novel therapeutic target for selected cancers....Full Text Available

231

Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer

Heart disease, cancer, and cerebrovascular disease together cause more than two out of three deaths in the United States annually. These three diseases are largely a result of widespread risk factors...Full Text Available

1986-01-01

232

Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism

BackgroundThe proteomics approach termed proteome pattern analysis has been shown previously to have potential in the detection and classification of breast cancer. Here we aimed...Full Text Available

233

Long-term disease-free survival after surgical resection for multiple bone metastases from rectal cancer

BackgroundSome breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell...Full Text Available

234

Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats

Bone metastasis of primary colorectal cancer is uncommon. When it occurs, it is usually a late manifestation of disease and is indicative of poor prognosis. We describe a patient with multiple metachronous...Full Text Available

2011-08-10

235

Life after Breast Cancer: Dealing with Lymphoedema

BackgroundIn a previous study conducted at the Cesare Maltoni Cancer Research Center of the European Ramazzini Foundation (CMCRC/ERF), we demonstrated for the first time that aspartame...Full Text Available

2007-09-01

236

Lessons to be Learned from 25 Years of Research Investigating Psychosocial Interventions for Cancer Patients

Background:In recent years, breast cancer (BC) mortality rates have declined, reflecting advances in early detection. Prevention and management of treatment sequelae that could impair...Full Text Available

237

Lack of Osteoradionecrosis of the Mandible after IMRT for Head and Neck Cancer: Likely Contributions of both Dental Care and Improved Dose Distributions

Conducting rigorous psychosocial intervention research with cancer patients has many challenges including encouraging them to join studies, asking them to engage in interventions or be part...Full Text Available

2009-01-01

238

Initial Report of the Cancer PROMIS Supplement Sexual Function Committee: Review of Sexual Function Measures and Domains Used in Oncology

PurposeTo assess the prevalence and the dosimetric and clinical predictors of mandibular osteoradionecrosis (ORN) in patients with head and neck (HN) cancer who underwent...Full Text Available

2007-06-01

239

Incidence of cancer among Finnish airline cabin attendants, 1967-92.

ObjectiveThis report describes initial activities of the Cancer Patient-Reported Outcomes Measurement Information System (PROMIS) Sexual Function domain group (CaPS-SF),...Full Text Available

2009-03-15

240

Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice

OBJECTIVE--To assess whether occupational exposure among commercial airline cabin attendants are associated with risk of cancer. DESIGN--Record linkage study. SETTING--Finland. SUBJECTS-1577 female...Full Text Available

1995-09-09

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241

Improvement of a Dendritic Cell-Based Therapeutic Cancer Vaccine with Components of Toxoplasma gondii?

Hyperproliferation of the colonic epithelium, leading to expansion of colonic crypt progenitors, is a recognized risk factor for colorectal cancer. Overexpression of progastrin, a nonamidated and incompletely...Full Text Available

2009-09-01

242

Impact of intraoperative lung-protective interventions in patients undergoing lung cancer surgery

The use of dendritic cells (DCs) as a cellular adjuvant is a promising approach to the immunotherapy of cancer. It has previously been demonstrated that DCs pulsed ex vivo with Toxoplasma gondii...Full Text Available

2009-10-01

243

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

IntroductionIn lung cancer surgery, large tidal volume and elevated inspiratory pressure are known risk factors of acute lung (ALI). Mechanical ventilation with low tidal volume...Full Text Available

2009-01-01

244

Identification and Functional Relevance of de novo DNA Methylation in Cancerous B-Cell Populations

Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level. Metformin increases lifespan and prevents cancer...Full Text Available

245

Hormone Receptor Status in Breast Cancer and its Relation to Age and Other Prognostic Factors

Epigenetic remodeling is a hallmark of cancer, with the frequent acquisition of de novo DNA methylation in CpG islands. However, the functional relevance of de novo...Full Text Available

2010-03-01

246

Background:Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers.Patients...Full Text Available

247

Haplotype of N-Acetyltransferase 1 and 2 and Risk of Pancreatic Cancer

PurposeIntestinal stomas can pose significant challenges for long-term (≥ 5 years) rectal cancer (RC) survivors. Specifying common challenges and sociodemographic or clinical...Full Text Available

2009-10-01

248

Green tea polyphenols for prostate cancer chemoprevention: A translational perspective

We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight...Full Text Available

2007-11-01

249

Genetically-engineered mouse models for pancreatic cancer: Advances and current limitations

Every year nearly 200,000 men in the United States are diagnosed with prostate cancer (PCa), and another 29,000 men succumb to the disease. Within certain regions of the world population based...Full Text Available

2010-01-01

250

Genetic association between the COMT genotype and urinary levels of tea polyphenols and their metabolites among daily green tea drinkers

Recently, there has been significant progress in the development of genetically-engineered mouse (GEM) models. By introducing genetic alterations and/or signaling alterations of human pancreatic cancer...Full Text Available

2011-05-10

251

Functional Enhancers at the Gene-Poor 8q24 Cancer-Linked Locus

Available in vitro and animal studies have shown cancer protective effects of tea polyphenols. Recent study suggests a greater protective effect of green tea intake on breast cancer...Full Text Available

252

Follow-up of patients with curatively resected colorectal cancer: a practice guideline

Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their...Full Text Available

2009-08-01

253

First line targeted therapies in breast cancer: focus on bevacizumab

BackgroundA systematic review was conducted to evaluate the literature regarding the impact of follow-up on colorectal cancer patient survival and, in a second phase, recommendations...Full Text Available

254

Figuring Out Sex in a Reconfigured Body: Experiences of Female Colorectal Cancer Survivors with Ostomies

The heterogeneity of metastatic breast cancer mandates the need to select therapies taking into account tumor and patient characteristics. Chemotherapy is indicated in the palliative setting especially...Full Text Available

2007-03-01

255

Fatigue and Functional Impairment in Early-Stage Non-Small Cell Lung Cancer Survivors

Colorectal cancer (CRC) survivors with ostomies can face complex concerns regarding sexuality. We used an anthropological perspective to examine the experiences of 30 female CRC survivors with...Full Text Available

2009-12-01

256

Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma

ContextFatigue is the most common sequela among non-small cell lung cancer (NSCLC) survivors 1–6 years post-treatment and is associated with functional limitations.Full Text Available

2011-02-01

257

Evaluation of support groups for women with breast cancer: importance of the navigator role

BackgroundNon-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize....Full Text Available

258

Estimation of cancer incidence and mortality attributable to alcohol drinking in china

BackgroundAt least some forms of breast cancer are increasingly being viewed as a chronic illness, where an emphasis is placed on meeting the various ongoing needs of people living...Full Text Available

259

Epigenetic Therapies for Chemoresensitization of Epithelial Ovarian Cancer

BackgroundCancer constitutes a serious burden of disease worldwide and has become the second leading cause of death in China. Alcohol consumption is causally associated with the...Full Text Available

260

Epidemiological appraisal of studies of residential exposure to power frequency magnetic fields and adult cancers.

SummaryEpigenetic drugs have been shown to enhance gene expression and drug sensitivity in ovarian cancer cell lines and animal models. Based on promising pre-clinical studies,...Full Text Available

2010-02-01

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261

Enhancing return-to-work in cancer patients, development of an intervention and design of a randomised controlled trial

OBJECTIVES: To appraise epidemiological evidence of the purported association between residential exposure to power frequency magnetic fields and adult cancers. METHODS: Literature review and epidemiological...Full Text Available

1996-08-01

262

Endobronchial Stent Insertion to Manage Hemoptysis caused by Lung Cancer

BackgroundCompared to healthy controls, cancer patients have a higher risk of unemployment, which has negative social and economic impacts on the patients and on society at large....Full Text Available

263

Diverging trends in incidence and mortality of testicular cancer in Denmark, 1943-1982.

Hemoptysis in patients with lung cancer is not uncommon and sometimes have dangerous consequences. Hemoptysis has been managed with various treatment options other than surgery and medicine, such as...Full Text Available

2010-08-01

264

Differing prognosis of cervical cancer patients with high risk of treatment failure after radical hysterectomy warrants trial treatment modification

Between 1943 and 1982, 5,140 new cases of testicular cancer were diagnosed in Denmark. The age-standardized incidence rate more than doubled in the period. Striking variations is seen in the age-relationship...Full Text Available

1986-04-01

265

Diesel engine exhaust and lung cancer: an unproven association.

ObjectiveThe aim of this study was to ascertain whether all cervical cancer patients who received adjuvant concurrent chemoradiation (CCRT) for high risk of treatment failure after...Full Text Available

2009-03-01

266

Development and validation of a high performance liquid chromatography method for the simultaneous determination of aspirin and folic acid from nano-particulate systems

The risk of lung cancer associated with diesel exhaust has been calculated from 14 case-control or cohort studies. We evaluated the findings from these studies to determine whether there is sufficient...Full Text Available

1995-09-01

267

Cytotoxicity of Atriplex confertifolia

Attention has shifted from the treatment of colorectal cancer (CRC) to chemoprevention using aspirin and folic acid as agents capable of preventing the onset of colon cancer. However, no sensitive...Full Text Available

2010-09-01

268

Current status of therapy for breast cancer worldwide and in Japan

The search for cancer treatment continues to be a global effort. As part of this global effort, many natural products have been tested against cancer cell lines, mostly from tropically located plants....Full Text Available

2010-01-01

269

Current practices in the spatial analysis of cancer: flies in the ointment

The results of clinical trials conducted in Europe and North America have been incorporated into treatment strategies for breast cancer in Japan. Despite the use of similar treatment regimens, why has...Full Text Available

2011-02-10

270

Comprehensive Management of Upper Tract Urothelial Carcinoma

While many lessons have been learned from the spatial analysis of cancer, there are several caveats that apply to many, if not all such analyses. As "flies in the ointment", these can substantially...Full Text Available

271

Common mitochondrial polymorphisms as risk factor for endometrial cancer

Urothelial carcinoma of the upper urinary tract represents only 5% of all urothelial cancers. The 5-year cancer-specific survival in the United States is roughly 75% with grade and stage being the most...Full Text Available

2009-01-01

272

Common Familial Colorectal Cancer Linked to Chromosome 7q31: a genome-wide analysis

Endometrial carcinoma is the most commonly diagnosed gynaecological cancer in developed countries. Although the molecular genetics of this disease has been in the focus of many research laboratories...Full Text Available

273

Colonic polyps: inheritance, susceptibility, risk evaluation, and diagnostic management

Present investigations suggest that approximately 30% of colorectal cancer (CRC) cases arise on the basis of inherited factors. We hypothesize that the majority of inherited factors are moderately...Full Text Available

2008-11-01

274

Clinical Implications of Immunohistochemically Demonstrated Lymph Node Micrometastasis in Resectable Pancreatic Cancer

Colorectal cancer (CRC) is the third-ranked neoplasm in order of incidence and mortality, worldwide, and the second cause of cancer death in industrialized countries. One of the most important environmental...Full Text Available

275

Childhood cancer mortality and radon concentration in drinking water in North Carolina.

The purpose of this study was to determine the clinical significance of nodal micrometastasis detected by immunohistochemistry in patients that had undergone curative surgery for pancreatic cancer....Full Text Available

2011-07-01

276

Childhood cancer and overhead powerlines: a case-control study.

We explored the association between groundwater radon levels and childhood cancer mortality in North Carolina. Using data from two state-wide surveys of public drinking water supplies, counties were...Full Text Available

1991-04-01

277

Chemoprevention of Nonmelanoma Skin Cancer With Celecoxib: A Randomized, Double-Blind, Placebo-Controlled Trial

A case-control study has been carried out to examine the occurrence of childhood cancer in relation to the proximity of overhead power lines to a child's home address at birth and to the calculated...Full Text Available

1990-12-01

278

Catalyzing Social Support for Breast Cancer Patients

BackgroundPreclinical studies indicate that the enzyme cyclooxygenase 2 plays an important role in ultraviolet-induced skin cancers. We evaluated the efficacy and safety of celecoxib,...Full Text Available

2010-12-15

279

Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in 500 patients.

Social support is a critical, yet underutilized resource when undergoing cancer care. Underutilization occurs in two conditions: (a) when patients fail to seek out information, material assistance,...Full Text Available

2010-01-01

280

Cancer in young people in the north of England, 1968-85: analysis by census wards.

Carcinoma in situ in the contralateral testis was diagnosed in 27 of 500 patients (5.4%) with unilateral testicular germ cell cancer. Eight of the 27 patients received intensive chemotherapy for spread...Full Text Available

1986-11-29

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281

CDC - Annual Report to the Nation on the Status of Cancer, 1975...

OBJECTIVE--To determine whether the seeming excess of childhood leukaemia and lymphoma identified in Seascale, Cumbria, UK, remains unusual when put into a wider context. DESIGN--Analysis of cancer...Full Text Available

1993-04-01

282

Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women

tumors make up two-thirds of all adult brain tumors and one-third of childhood brain tumors. Cancer Among Men, 2003-2007 Incidence rates decreased for lung, colorectal,...

2011-10-15

283

Blood leukocyte DNA hypomethylation and gastric cancer risk in a high-risk Polish population

BackgroundTwo clinically relevant high-risk HPV (HR-HPV) types 16 and 18 are etiologically associated with the development of cervical carcinoma and are also reported to be present...Full Text Available

284

Blood Storage Duration and Biochemical Recurrence of Cancer After Radical Prostatectomy

Global hypomethylation has been shown to increase genome instability potentially leading to increased cancer risk. We determined whether global methylation in blood leukocyte DNA was associated...Full Text Available

2010-10-15

285

Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment

OBJECTIVE: To test the hypothesis that perioperative transfusion of allogeneic and autologous red blood cells (RBCs) stored for a prolonged period speeds biochemical recurrence of prostate cancer...Full Text Available

2011-02-01

286

Association between intratumoral lymphatic microvessel density (LMVD) and clinicopathologic features in endometrial cancer: a retrospective cohort study

BackgroundThis is a preliminary report of an ongoing prospective bimodality lung cancer surveillance trial for high‐risk patients. Bimodality surveillance incorporates autofluorescence...Full Text Available

2007-04-01

287

Assessment of nodal target definition and dosimetry using three different techniques: implications for re-defining the optimal pelvic field in endometrial cancer

BackgroundLymph node metastasis in endometrial cancer significantly decreases survival rate. Few data on the influence of intratumoral lymphatic microvessel density (LMVD) on survival...Full Text Available

288

An Analysis of Heavy Utilizers of Opioids for Chronic Non-Cancer Pain in the TROUP Study

Purposes1. To determine the optimal pelvic nodal clinical target volume for post-operative treatment of endometrial cancer. 2. To compare the DVH of different treatment planning...Full Text Available

289

Alcohol-folate interactions in women's oral cancer risk: A prospective cohort study

ContextWhile opioids are increasingly used for chronic non-cancer pain (CNCP), we know little about opioid dosing patterns among individuals with CNCP in usual care...Full Text Available

2010-08-01

290

Acute aortic thrombosis in patients receiving cisplatin-based chemotherapy

BackgroundThe aim of this cohort study was to quantify the effect of alcohol in the risk of oral cancer in different strata of folate intake, controlling for known...Full Text Available

2010-10-01

291

Activation of Cytotoxic and Regulatory Functions of NK Cells by Sindbis Viral Vectors

The increased risk of thrombosis in patients with active cancer has multiple causes. Acute thrombosis of the aorta is an exceedingly rare but potentially devastating complication in patients with cancer...Full Text Available

2011-04-01

292

A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer

Oncolytic viruses (OVs) represent a relatively novel anti-cancer modality. Like other new cancer treatments, effective OV therapy will likely require combination with conventional treatments. In order...Full Text Available

293

A decision-analytic approach to define poor prognosis patients: a case study for non-seminomatous germ cell cancer patients

IntroductionVarious multigene predictors of breast cancer clinical outcome have been commercialized, but proved to be prognostic only for hormone receptor (HR) subsets overexpressing...Full Text Available

2010-01-01

294

A church-based intervention to promote informed decision-making for prostate cancer screening among African-American men

BackgroundClassification systems may be useful to direct more aggressive treatment to cancer patients with a relatively poor prognosis. The definition of 'poor prognosis' often lacks...Full Text Available

295

A Multi-Method Process Evaluation for a Skin Cancer Prevention Diffusion Trial

ObjectivesThis feasibility study developed and pilot tested an intervention to: (1) increase knowledge about prostate cancer (CaP) screening; and (2) promote self-efficacy...Full Text Available

2010-03-01

296

This article describes process evaluation methods for the Pool Cool Diffusion Trial across four years. Pool Cool is a skin cancer prevention program that was...Full Text Available

2009-06-01

297

?H2AX and cancer

The Oak Ridge Y-12 Plant biological monitoring and abatement program for East Fork Poplar Creek

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer...Full Text Available

2008-12-01

298

Integrated model of the shallow and deep hydrothermal systems in the East Mesa area, Imperial Valley, California

In May 1985, a National Pollutant Discharge Elimination System permit was issued for the Oak Ridge Y-12 Plant, a nuclear weapons components production facility located in Oak Ridge, Tennessee, and operated by Martin Marietta Energy Systems, Inc., for the US Department of Energy. As a condition of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed to demonstrate that the effluent limitations established for the Oak Ridge Y-12 Plant protect the classified uses of the receiving stream (East Fork Poplar Creek), in particular, the growth and propagation of fish and aquatic life, as designated by the Tennessee Department of Health and Environment. A second purpose for the BMAP is to document the ecological effects resulting from implementation of a water pollution control program that will include construction of nine new wastewater treatment facilities over the next 4 years. Because of the complex nature of the effluent discharged to ...

1989-10-01

299

Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells

Geological, geophysical, thermal, petrophysical and hydrological data available for the East Mesa hydrothermal system that are pertinent to the construction of a computer model of the natural flow of heat and fluid mass within the system are assembled and correlated. A conceptual model of the full system is developed and a subregion selected for quantitative modeling. By invoking the Boussinesq approximation, valid for describing the natural flow of heat and mass in a liquid hydrothermal system, it is found practical to carry computer simulations far enough in time to ensure that steady-state conditions are obtained. Initial calculations for an axisymmetric model approximating the system demonstrate that the vertical formation permeability of the deep East Mesa system must be very low (k/sub v/ approx. 0.25 to 0.5 md). Since subsurface temperature and surface heat flow data exhibit major deviations from the axisymmetric approximation, ...

1982-01-01

300

Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells.

Full Text Available

2011-03-01

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301

The reirradiation of the cavum cancer. Experience of the oncology center Ibn-Rochd of Casablanca (C.O.I.R.); La reirradiation du cancer du cavum. Experience du centre d'oncologie Ibn-Rochd de Casablanca (COIR)

Full Text Available

2009-09-01

302

New mass screening project for lung cancer with mobile spiral computed tomography (CT) and computed radiography (CR) in Ehime district

The radiotherapy is the prime treatment for the cavum cancer. It is also useful to treat the tumor recurrences, in this case the reirradiation stays the only efficient therapy option to give a correct local control. The reirradiation, exclusive or in association with other therapies can contribute to the local control of cavum cancer recurrences with a survival rate at five years of 36 to 58%. (N.C.)

2006-11-15

303

Detection of Mitochondrial DNA Mutations in Mammary ...

To improve the detection rate of lung cancer, we have introduced low-dose CT and CR technique into a population-based annual mass screening. From December 1999, 3868 and 12618 individuals participated in this screening program with CT and with CR, respectively. Primary lung cancer was detected in 15 (0.39%) by CT and 8 (0.06%) by CR. This results show high detection rate of primary lung cancer as had been previously reported. (author)

2002-01-01

304

Synergistic epigenetic reactivation of estrogen receptor-? (ER?) by combined green tea polyphenol and histone deacetylase inhibitor in ER?-negative breast cancer cells

... Loss of Heterozygosity in Normal Breast Epithelial Tissue and Benign Breast Lesions in BRCA1/2 Carriers with Breast Cancer. ...

2004-09-01

305

Proton beam therapy for cancer in deep-seated organs

BackgroundThe status of estrogen receptor-α (ERα) is critical to the clinical prognosis and therapeutic approach in breast cancer. ERα-negative breast cancer...Full Text Available

306

Mammography: limits of a technique

Radiation therapy has shown definite technical improvement due to application of proton beam irradiation. Clinical results of proton beam therapy also suggested enlargement of indication ranges in radial treatment and decrease of post radiation damages of the treatment of cancers in deep-seated organs. Inprovement of result in cancer therapy could be expected by this treatment technique in the future.

1988-10-01

307

Long-term chemical carcinogenesis experiments for identifying potential human cancer hazards: collective database of the National Cancer Institute and National Toxicology Program (1976-1991).

Breast cancer represents today more than 30% of all cancers and is responsible for about 20% of deaths due to cancer. The potentialities of mammography have increased in recent years through improvements in equipment and methodologies. In this paper the conventional mammography using film and image intensifiers is compared with digital mammography. Digital mammography presents clear advantages in storage and handling of information. Also its higher sensitivity will lead to an earlier detection of anomalies and a decrease in the number of invasive exams and surgeries

2001-05-01

308

LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells

The carcinogenicity database used for this paper originated in the late 1960s by the National Cancer Institute (NCI) and since 1978 has been continued and made more comprehensive by the National Toxicology...Full Text Available

1991-12-01

309

Indian Academy of Sciences - Summer Fellowships 2005

BackgroundAs EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It...Full Text Available

310

Indian Academy of Sciences (India)

kodali, mr (iii b.tech.) anil neerukonda inst. of science and chandrashekaran ramachandra reddy shekhar c mande lang="en-gb">kandavelmani, reg. cancer cen., trivandrum panda panda lang="en-gb">dr anand imtech, chandigarh lang="en-gb">ravichandran, reg. cancer cen., trivandrum reg. cancer cen., trivandrum chandrasekar, dr (lecturer) psg college of arts & science, imtech, chandigarh ...

311

Molecular phylogeography of the microturbellarian Monocelis lineata (Platyhelminthes: Proseriata) in the North-East Atlantic

British Library Electronic Table of Contents (United Kingdom)

Monocelis lineata is a complex of cryptic species (three in the Mediterranean and one in the Atlantic) widespread in midlittoral habitats. Throughout the range, populations with or without an ocular pigmented shield are found. We investigated the genetic structure of the North-East Atlantic populations with the aim of shedding light on their phylogeography and reconstructing possible patterns of recolonization after the Wrmian glaciation. Fourteen samples were investigated using cytochrome c oxidase subunit I (COI) and 13 by inter-simple sequence repeats (ISSRs). COI did not exhibit a clear pattern of decreased genetic diversity along a latitudinal gradient. Populations from Ferrol (Spain), Doolin (Ireland), and Helsingr (Denmark) showed a higher genetic variability, whereas a reduction in...

2011-01-01

312

Is there a twenty year wave in the dirunal anisotropy of cosmic rays

Hydraulic Fracture Stimulation Treatments at East Mesa, Well 58-30; Geothermal Reservoir Well Stimulation Program; Experiment 3 and 4

We have analyzed data obtained with the Deep River neutron monitor and the underground vertical muon telescope at Embudo for the period 1965--79. Our data in conjunction with other published data show that for 1957--70 the diurnal anisotropy is unidirectional; with direction along 18 hour LT (east-west). During 1971--79, the diurnal anisotropy consists of two components. One is in east-west direction and the other is the radial component, with direction along 12 hour LT. The latter attains a maximum amplitude in 1976. We find no evidence for the existence of the twenty year wave in the diurnal anisotropy of cosmic rays. copyright American Geophysical Union 1988

1988-04-01

313

Environmental planning for geothermal energy resource exploration, development, and utilization

The tests reported were part of the DOE Geothermal Reservoir Well Stimulation Program. This East Mesa (Imperial Valley, CA) well was successfully stimulated with two fracture treatments, a dendritic fracture and a planar fracture. The natural flow production of the well increased 114 percent, to 197,900 lb/hr. These tests were among the few successful attempts of this program to increase flow from geothermal production wells. The general belief is that these tests worked OK primarily because the formation was sedimentary rock (similar to rock in most oil and gas wells that have been stimulated successfully. Similar tests in geothermal hard rock reservoirs did not work very well. (DJE 2005)

1982-02-01

314

Capturing the value of coastal ecosystem services for poverty alleviation in East and Southern Africa

The commercialization of geothermal energy resources consists of a sequence of exploration, development, and utilization activities. Each of these activities are beset by both generic and project specific technical, environmental, and institutional constraints which must be adequately resolved before geothermal operations can be conducted. This report presents a summary of selected environmental activities conducted during the early planning stages of geothermal resource commercialization. Three representative activities are elaborated upon. These include preliminary environmental planning for geothermal energy development in the Medicine Lake Highlands of California; potential alternatives for non-electric use of the geothermal resource at East Mesa in Imperial County, California; and site specific studies of the impacts from using East Mesa geothermal fluids to irrigate selected crops and indigenous climax vegetation.

1982-01-01

315

Environmental Research Database

ObjectivesCoastal ecosystems in developing countries supply a diverse range of services to local communities and national economies, including fish production, protection against floods and storms and support to tourism. Multiple drivers of change are influencing the status of the ecosystems, most of which are anthropogenic (Brown et al., 2006). Managing coastal ecosystems requires recognition of the diverse range of uses and users, and coordination between structures and processes, many of which are curr [continued...]DescriptionCommitment to the management of coastal ecosystems through addressing both ecological and social objectives already exists in East and Southern Africa (Glavovic 2006; Gustavson et al. 2009). More understanding, however, of the ecosystem services of priority to the poor and to poverty alleviation would strengthen the capacity of these initiatives to deliver on poverty alleviation and resource sustainability. The coastal regions of Tanzania, ...

2010-01-31

316

Approaching the ?Resistant:? Exploring East Asian International Students? Perceptions of Therapy and Help-Seeking Behavior Before and After They Arrived in the United States

British Library Electronic Table of Contents (United Kingdom)

In this study we investigated cultural, familial, and individual beliefs that influenced international students? perceptions of therapy and help-seeking behaviors. Included were changes in perception or behavior before and after the students came to the US, and factors that influenced help-seeking behaviors. Six international students from East Asian countries where English is a foreign language, including Taiwan, Mainland China, Japan, and South Korea, were interviewed. We used semi-structured interviews and participant observations for collecting data. The findings indicated changes after students came to the US. Further discussions focus on encouraging and discouraging factors relative to seeing therapists, and culturally sensitive interventions for family therapy clinicians.

2011-01-01

317

Air pollution in Berlin and its surroundings in 1989. Luftverschmutzung in Berlin und Umgebung im Jahr 1989

Selective changes of retroelement expression in human prostate cancer

The report presents details of the distributions of air pollution in the Berlin area and the developments of the past 20 years. Highly polluted areas are indicated in which air pollution reduction measures are particularly urgent. The report therefore intends not only to inform but also to point out the deficiencies of air pollution abatement measures, so that political consequences can be derived and measures can be taken. In all, data were recorded by 39 measuring stations in West Berlin, 16 in East Berlin, and 7 in Potsdam and Frankfurt/Oder. In most stations, sulphur dioxide and airborne dust were measured; 14 stations in West Berlin and one in East Berlin measured carbon monoxide and nitric oxides; 8 stations in West Berlin recorded ozone concentrations. (orig./KW).

1990-10-01

318

British Library Electronic Table of Contents (United Kingdom)

Retroelements constitute a large part of the human genome. These sequences are mostly silenced in normal cells, but genome-wide DNA hypomethylation in cancers might lead to their re-expression. Whether this re-expression really occurs in human cancers is largely unkown. We therefore investigated expression and DNA methylation of several classes of retroelements in human prostate cancer tissues and cell lines by quantitative reverse transcription-polymerase chain reaction and pyrosequencing, respectively. The most striking finding was strong and generalized increased expression of the HERV-K_22q11.23 provirus in cancers, including de novo expression of a spliced accessory Np9 transcript in some tumors. In parallel, DNA methylation in the long terminal repeat (LTR) decreased. Conversely, HER...

2011-01-01

319

Quality of life after surgery for rectal cancer with special reference to pelvic floor dysfunction

British Library Electronic Table of Contents (United Kingdom)

Abstract Aim- Conventional outcomes such as survival, tumour recurrence and complication rates after surgery for rectal cancer have been rigorously assessed, but the importance of maintaining quality of life (QOL) after surgery for rectal cancer has received less attention. The aim of the current study was to analyse QOL and the occurrence of pelvic dysfunction after the surgical treatment of rectal cancer. Method- Between May 2005 and May 2008, 150 patients with rectal cancer underwent abdominoperineal resection (APR) or anterior resection (AR). Seventy-four answered two preoperative questionnaires. At a follow up of 1-year, 65 were alive without sign of recurrence and answered the same questionnaires: (a) validated RAND 36-item health survey QOL questionnaire; and (b) self-administered d...

2011-01-01

320

Pain measurement: the affective dimensional measure of the McGill pain questionnaire with a cancer pain population.

Isoflavone content and apoptotic effect in HT-29 cancer cells of a soy germ extract

Two experiments used the McGill Pain Questionnaire (MPQ) to examine the affective dimension of pain in patients whose pain was secondary to malignancy. In experiment I, segregating groups of cancer patients on the basis of extreme scores (high versus low) on the MPQ failed to produce segregation on independent measures of affect and infirmity. This outcome contrasts with earlier work with chronic benign pain patients. Experiment II compared cancer pain patients matched with benign pain patients on intensity of pain report on the affective dimension of the MPQ. Cancer pain patients reported a reliably higher affective loading to their pain. These data suggest that cancer pain patients employ different criteria than benign pain patients in selecting affective pain descriptors. Possible explanations for this difference are discussed. PMID:7070825

1982-02-01

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321

British Library Electronic Table of Contents (United Kingdom)

Colon cancer is one of the leading causes of death and a major public health problem in western countries. We examined the isoflavone content of 70% ethanol extract of soy germ (SG) and its apoptotic effect in HT-29 colon cancer cells. Our results showed that the major isoflavones of the SG extract were daidzein and genistein, and it effectively induced apoptosis in HT-29 cancer cells. In addition, nuclear factor-kappa B (NF-kB) expression was reduced in cells treated with the SG extract, which reduced cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS) expression. These combined effects ultimately resulted in apoptosis via caspase-3 activation. In addition, daidzein and genistein, the major isoflavones of SG extract, also exerted the apoptotic effect against HT-29 cancer cells. Thes...

2012-01-01

322

Application of microvascular free osteocutaneous flaps in the management of post-radiation recurrent oral cancer

Some thoughts on stem cells and carcinogenesis. The thyroid gland

Fifty-nine patients underwent free flap osteocutaneous reconstruction that consisted of flaps of the dorsum of the foot in 26 patients and iliac crest flaps in 33 with a success rate of 92 percent and a mortality rate of 1.6 percent. These flaps, which require the expertise of microvascular surgeons, are time-consuming and complicate operating room and time management, but they represent a remarkable advance in reconstruction that can facilitate cosmetic and functional recovery of the patient. In particular, they promote healing in radiation-recurrent oral cancer and represent a definitive form of management for established radionecrosis of the mandible. The large volume of tissue available with iliac crest osteocutaneous grafts permits the management of patients with extensive cancer involving the skin, mucosa, and bone, but cancer control may still be disappointing and there is a need for improved adjuvant chemotherapy ...

1985-10-01

323

Efficacy of MR mammography (MRM) in providing preoperative locoregional information on breast cancer. Correlation between MRM and histological findings

The purpose of this review is to consider the hypothesis that cancer frequently originates from stem cells. Using the spleen transplantation assay where stem cells were transplanted in the spleen of mice lethally irradiated by ionizing radiation, the author undertook a study aimed at defining the risk of radiogenic cancer per susceptible cells with use of rat radiogenic mammary and thyroid cancers because of the high incidences of these cancers in a-bomb survivors. Measured were the number of cancer-susceptible cells initially present in the tissue, the number of such cells that survived at a given dose and the number of cancers that developed per surviving cell. Thyroid cell differentiation and proliferation in rats transplanted with thyroid cells were enhanced by thyroidectomy and low iodine diet. Further, the relationship between the low LET radiation dose ...

2000-07-01

324

Childhood cancer in the surroundings of German nuclear power plants: report of an ongoing epidemiological study; Krebs bei Kindern in der Umgebung von Kernkraftwerken: Bericht zu einer laufenden epidemiologischen Studie

The purpose of this study was to assess the efficacy of MRM in providing preoperative locoregional information on patients with breast cancer. MRI was performed on 62 female breast cancer patients. A 1.5 T MR-system was used to acquire fat-suppressed T{sub 1}WI, T{sub 2}WI and dynamic-contrast-enhanced images with an SPGR pulse sequence. The extent of the cancer measured with MRM was confirmed histologically in all patients. The size obtained from MRM correlated well with the size obtained histologically, including intraductal spread of cancer (R: 0.853). As for shape, the round/oval type evident from MRM correlated more accurately (R: 0.934) than the ill-defined type associated with a linear and/or clumped enhanced area (R:0.744). The difference between the size obtained from MRM and the size obtained histologically, including IDS, was less than 15 mm in the majority of patients (93.5%). MRM accurately ...

2002-07-01

325

Who is to blame for the climate changes; Hvem har skylden for klimaendringene

Epidemiological studies could not show an association between ionising radiation of nuclear power stations in routine operation and the incidence of childhood cancer, yet. The following report presents a case control study conducted by the German Childhood Cancer Registry since autumn 2003. All children in the study region, who were diagnosed with cancer between 1980 and 2003 at an age below five are included. In the first part of the study we investigate whether children with cancer (cases) lived closer to the respective nuclear power stations compared to random children without cancer (controls). In the second part, for a subgroup of cases and controls we conduct computer assisted telephone interviews regarding confounders possibly associated with the exposure of ionising radiation and childhood cancer. Results are expected by the end of 2006. (orig.)

2006-07-01

326

Waste minimization and pollution prevention in D&D operations at the Argonne National Laboratory-East site

The article surveys studies into the global warming which have found that the OECD countries are responsible for less than half of the total registered warming. Calculation and analysis methods for estimating the global contributions from the blocks of OECD, Africa/America/Middle East, Asia and former Soviet Union/Eastern Europe are presented. The results and some pollution abatement measures are discussed.

2003-07-01

327

Socio-economic differences and health seeking behaviour for the diagnosis and treatment of malaria: a case study of four local government areas operating the Bamako initiative programme in south-east Nigeria

Argonne National Laboratory (ANL) is implementing waste minimization and pollution prevention activities into its conduct of decontamination and decommissioning (D&D) projects. Many of these activities are rather straight forward and simple approaches, yet they are often overlooked and not implemented as often as they should or could be. Specific activities involving recycling and reuse of materials and structures, which have proven useful in lowering decommissioning and disposal costs on D&D projects at ANL are presented.

1996-07-01

328

Microwaves - the hidden danger. Mikrowellen - die verheimlichte Gefahr

BackgroundMalaria is one of the leading causes of mortality and morbidity in Nigeria. It is not known how user fees introduced under the Bamako Initiative (BI) system affect healthcare...Full Text Available

329

Methanol, MTBE suppliers will likely keep up with rising demand

Today, highly frequent radio waves are regarded as undangerous to man. Diseases seen at radar-technicians during the 2nd World War, however, indicated that microwaves applied in radar systems were hazardous to health. The Russian work medicine has been knowing microwave-caused hazards in industry since the beginning of the thirties. Therefore in some East-European countries there are terms of protection and severe norms of safety for the staying of persons in the radiation sphere of microwaves.

1987-01-01

330

Fracture characterizatioin of the Bandelier tuff in OU-1098 (TA-2 and TA-41)

A primary and basic question prevails in the methanol industry - What will be the global demand for methanol, for the expanded production of methyl tertiary butyl ether (MTBE), during the next few years This article attempts to answer the question by discussing the global market; supply and demand factors; the market in North America, Western Europe, Far East and Asia, South America, and other regions; and the uncertainties that remain.

1993-03-29

331

Forum: Science and Innovation for Sustainable Development

Rock fracture characterization documents a total of 1496 fractures in unit 2 of the Tshirege Member of the Bandelier Tuff along 6013 feet of Los Alamos Canyon`s north wall adjacent to Operational Unit 1098. Geologically termed joints, these fractures likely owe their primary origin to brittle failure during the cooling contraction of the tuff after its emplacement nearly 1 million years ago. Subsequent tectonic movement along the Pajarito Fault system has modified fracture strikes, dips, apertures, and linear density. From a background linear density of approximately 20 fractures per 100-foot interval along the canyon wall, fracture density increases to values in excess of 50 fractures per 100-foot interval in a zone at and immediately east of the Omega West reactor building TA-2-1. This increase in fracture density is coincident with the mapped trace of the Guaje Mountain Fault (GMFZ) that apparently bifurcates with a branch running through the canyon at Building ...

1996-10-01

332

Far East combined-cycle update

...Studies People Projects Opportunities Framework Critical Sectors Development Goals Geographic Region Geographic Scale Research Themes Printer-Friendly MSU Environmental Science and Policy Program Michigan State University East Lansing , Michigan Type: Program Education Level: Graduate Event Duration: Ongoing Philosophy of the doctoral specialization: In the ...

333

FY 1997 report on the survey of potential impacts of enlarging ASEAN on political and economic systems in South East Asia; 1997 nendo chosa hokokusho (ASEAN kakudai no Higashi Asia no seiji keizai chitsujo eno eikyo chosa)

Korea Electric Power Corporation (Kepco) of South Korea has awarded Asea Brown Boveri Switzerland, a member of the ABB Group, a contract to supply the main equipment for two gas-fired combined-cycle power stations. News of the contract followed an announcement last year that Kepco will build a series of gas-fired power stations in the early 1990s to supply electricity to new housing and commercial areas being built in the Seoul-Incheon connurbation. (author).

1991-03-01

334

Evaluation of SO2 Emission Control Technology Applicable to the East Helena Lead Smelter.

This report surveys potential impacts of ASEAN (Association of South East Asian Nations) on inter-ASEAN affairs and its external relations when ASEAN will enlarge its members to include all nations in South East Asia, and thus fully represent the region. For this purpose, the survey was conducted on Vietnam, Myanmar, Laos and Cambodia, which joined in 1995, from the viewpoint of their economic and political system, and their relations with other member countries. The nature of ASEAN has gradually transformed, in which all the countries in the region have increased and internal economic issues have been tackled. It has an aim to stimulate inter-ASEAN trade and induce foreign direct investment into ASEAN as a whole by reducing import duties on intra-ASEAN trade. Underlying in these, new development is a concern about growing economic and military power of China. ASEAN solidarity will work an leverage against China should change toward worse, and ...

1998-03-01

335

EFFECTS OF PH AND PHOSPHATE ON METAL DISTRIBUTION WITH EMPHASIS ON AS SPECIATION AND MOBILIZATION IN SOILS FROM A LEAD SMELTING SITE

Contents: Lead smelter operations generating SO2 and particulate; Sulfuric acid plant technology; Lead smelters with sulfuric acid plant SO2 control; Sulfuric acid plant operation with lead sinter machine problems and solutions; SO2 control for ASARCO lea...

1975-01-01

336

Drilling fluid/formation interaction at simulated in situ geothermal conditions. Final report

Arsenic in soils from the Asarco Lead Smelter in East Helena, Montana was characterized by X-ray absorption spectroscopy (XAS). As oxidation state and geochemical speciation were analyzed as a function of depth (two sampling sites) and surface distribution. These results were c...

337

Direct application of West Coast geothermal resources in a wet-corn-milling plant. Final report

Interaction of drilling fluids with a geothermal reservoir formation can result in significant permeability impairment and therefore reduced well productivity. This interaction is studied under simulated in situ geothermal conditions of overburden stress, pore fluid pressure, temperature, and pore fluid chemistry. Permeability impairment of an East Mesa KGRA reservoir material is evaluated as a function of stagnation time, drilling fluid, and temperature. Results indicate that all of these parameters contribute significantly to the magnitude and the reversibility of the impairment.

1980-07-01

338

Coal potential of Antartica

The engineering and economic feasibility of using the geothermal resources in East Mesa, California, in a new corn processing plant is evaluated. Institutional barriers were also identified and evaluated. Several alternative plant designs which used geothermal energy were developed. A capital cost estimate and rate of return type of economic analysis were performed to evaluate each alternative. (MHR)

1981-03-01

339

Bioenergy from agro-industrial residues in the East African region. Summary report

This report attempts to bring together available information on the coal deposits of Antarctica and discuss factors that would be involved if these deposits were to be explored and mined. Most of the reported principal coal deposits in Antarctica lie generally within the Transantarctic Mountains: the majority are of Permian age and are present in the Victoria Group of the Beacon Supergroup. Several other deposits have been recorded in East Antarctica and in the Antarctic Peninsula, including minor occurrences of Mesozoic and Tertiary coal and carbonaceous shale.

1987-01-01

340

Tanzania has recently developed a comprehensive environmental policy which has put high priority on several specific environmental issues. One of the issues is the quality of waste water. A special priority is given to the pollution from the sisal industry. The East-African agro-industries generate very large quantities of organic residues from production and processing of different crops. These residues form a major contribution to the pollution of air, soil and waterways, but, at the same time they constitute a large potential for production of bioenergy through anaerobic digestion as well as potential substrate for other biological fermentation processes. Generally, these residues are regarded as having no or very little value and the different disposal methods are mainly a matter of getting rid of the waste. The generation of residues are very often concentrated on few large units, which makes the exploitation of these resources feasible in large scale biogas ...

1998-05-01

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341

Bibliography of prosopis

Association of sea turtles with petroleum platforms in the north-central Gulf of Mexico

References covering the years 1904-80 are listed under the following headings: cultivation and occurrence (India and Pakistan, Africa, South America, Pacific, Middle East); Taxonomy, morphology, variation and selection; Reference works and reviews; Ecology of Prosopis (General effects on surrounding soil and vegetation): Physiology (General, Roots, Growth, Hydrology, Saline tolerance); Control of mesquite: Propagation (Germination and other nursery techniques, Vegetative propagation): and Utilization (General, Chemical analyses, Food and Ethnobiology, Fodder, Wood, Charcoal, Gum, Paper). 141 references.

1981-01-01

342

There are over 4,500 petroleum platforms in the north-central Gulf of Mexico. Explosives are commonly used to remove platforms and have the potential to kill nearby sea turtles. From June 1988-June 1990, the authors used aerial surveys to study turtle density and the spatial relationship between turtles and platforms offshore of Louisiana. They sighted 316 turtles most of which (92%) were loggerheads. Seventy-eight percent were sighted just east of the Mississippi River offshore of the Chandeleur Islands. East of the river, turtle densities ranged from 0.92 (winter) to 4.83 turtles/100 sq km (spring). West of the river, annual densities ranged from 0.11-0.50 turtles/100 sq km. East of the river, three statistical tests indicated that turtles were generally closer to platforms than expected by chance alone. West of the river, turtles were randomly located with respect to platform locations. Before explosives are used, ...

1990-06-01

343

See Part 1

In-vitro radioimmunoassay of prostate specific antigen (PSA) for the screening and management of prostate cancer in Lebanon

Since 1998, The Pennsylvania State University successfully managed the Consortium for Premium Carbon Products from Coal (CPCPC), which was a vehicle for industry-driven research on the promotion, development, and transfer of innovative technologies on premium carbon products from coal to the U.S. industry. The CPCPC was an initiative led by Penn State, its cocharter member West Virginia University (WVU), and the U.S. Department of Energy's (DOE) National Energy Technology Laboratory (NETL), who also provided the base funding for the program, with Penn State responsible for consortium management. CPCPC began in 1998 under DOE Cooperative Agreement No. DE-FC26-98FT40350. This agreement ended November 2004 but the CPCPC activity continued under cooperative agreement No. DE-FC26-03NT41874, which started October 1, 2003 and ended December 31, 2010. The objective of the second agreement was to continue the successful operation of the CPCPC. ...

2010-12-31

344

V-band Photometry Of By Draconis-type Variables; Probing Long-term Activity Cycles In Three Pleiades Members

Full text: Immunoassays for prostate-specific antigen (PSA) are used to detect early-stage prostate cancer, monitor disease progress, and evaluate therapeutic response. At least two forms of PSA, free PSA (F-PSA) and PSA complexed to alpha-1 anti-chymotrypsin (PSA-ACT) are detected by commercial PSA assays. The fraction of F-PSA is shown to be smaller in patients with untreated prostate cancer than in patients with benign prostate hyperplasia (BPH). Thus, combined measurements of both total and free PSA are used for a better discrimination between BPH and prostate cancer. Detection of PSA for screening of prostate cancer has been a subject of debate for many years. The reason of this debate is mainly because screening for prostate cancer is not cost-effective, as was shown by studies undertaken in Europe and United States. In Lebanon, no previous programs of screening for prostate ...

2004-01-01

345

The use of alloy 800 in the THTR steam generator

Through the collaborative efforts of undergraduates and faculty at Gettysburg and Franklin & Marshall Colleges, we present the compilation of 10 years of differential photometry for three K-type stars in the Pleiades. These young stars have rotational light curves with V-band amplitudes of a few percent (10% in the most active) due to BY Draconis-type behavior (modulation due to rotation of a star with non-uniform surface brightness). With 10 years of photometry reduced, measured, and compiled we are now in a position to probe the V-band variations in these stars for indications of the extent of brightness asymmetry in the photosphere, and characteristics of the long-term activity of these stars. These observations were acquired at the National Undergraduate Research Observatory, operated by Lowell Observatory and Northern Arizona University. This work is supported by Gettysburg College, the Pennsylvania Space Grant Consortium, Arizona Space Grant, NSF grant ...

2007-05-01

346

The DG environment project ''Dioxin emissions in candidate countries''. Scope, approach and first results

In 1972 a consortium consisting of Gebruder Sulzer A.G., Winterthur and EVT, Energie- und Verfahrenstechnik G.m.b.H., Stuttgart, was awarded the contract by HBR, Hochtemperatur Reaktorbau G.m.b.H., Koln/Mannheim, for the design, manufacture and installation of the 6 steam generator units for the prototype 300 MWe Thorium High Temperature Reactor (THTR) at Schmehausen, Germany. The design and manufacture of the 6 units is done by Sulzer; installation of the units as well as the manufacture of the external pipework and headers is done by EVT. The units are built under semiclean conditions in a special workshop at CCM-Sulzer in mantes, France. This workshop had been used previously for the manufacture of the steam generators for the nuclear power plants St. Laurent I, II, Vandellos (500 Mwe each) and EL-4 (70 Mwe). The present paper defines the operating conditions and the chemical composition of the materials used, including Alloy 800. Reasons for the choice of Alloy ...

347

Progress Report 2008: A Scalable and Extensible Earth System Model for Climate Change Science

The European Commission recently has adopted a new European Strategy for Environment and Health focusing on the growing concern over the adverse health effects caused by environmental pollution. Based on the results of various studies carried out in recent years polychlorinated dioxins and furans (PCDD/Fs) and PCBs are playing an important role in this strategy. In view of the enlargement of the European Union (EU) to include Candidate Countries (CCs) the Commission stressed the need to involve the Candidate Countries from an early stage on in the development of such a strategy. Thus two studies have been commissioned which are particularly directed to provide a) an overview on environmental levels and human exposure of dioxins and PCBs and b) an harmonised PCDD/F emission inventory for the target matrices air, water and land The latter study, entitled ''Dioxin Emissions in Candidate Countries'' is carried out by a consortium of ...

2004-09-15

348

Methanogens and sulfate-reducing bacteria in oil sands fine tailings waste.

This project employs multi-disciplinary teams to accelerate development of the Community Climate System Model (CCSM), based at the National Center for Atmospheric Research (NCAR). A consortium of eight Department of Energy (DOE) National Laboratories collaborate with NCAR and the NASA Global Modeling and Assimilation Office (GMAO). The laboratories are Argonne (ANL), Brookhaven (BNL) Los Alamos (LANL), Lawrence Berkeley (LBNL), Lawrence Livermore (LLNL), Oak Ridge (ORNL), Pacific Northwest (PNNL) and Sandia (SNL). The work plan focuses on scalablity for petascale computation and extensibility to a more comprehensive earth system model. Our stated goal is to support the DOE mission in climate change research by helping ... To determine the range of possible climate changes over the 21st century and beyond through simulations using a more accurate climate system model that includes the full range of human and natural climate feedbacks with increased realism and ...

2009-01-01

349

High-efficiency Hybrid Solar Cells for Micro-generation

In the past decade, the large tailings pond (Mildred Lake Settling Basin) on the Syncrude Canada Ltd. lease near Fort McMurray, Alta., has gone methanogenic. Currently, about 60%-80% of the flux of gas across the surface of the tailings pond is methane. As well as adding to greenhouse gas emissions, the production of methane in the fine tailings zone of this and other settling basins may affect the performance of these settling basins and impact reclamation options. Enumeration studies found methanogens (10(5)-10(6) MPN/g) within the fine tailings zone of various oil sands waste settling basins. SRB were also present (10(4)-10(5) MPN/g) with elevated numbers when sulfate was available. The methanogenic population was robust, and sample storage up to 9 months at 4 degrees C did not cause the MPN values to change. Nor was the ability of the consortium to produce methane delayed or less efficient after storage. Under laboratory conditions, fine tailings samples ...

2000-10-01

350

Environmental Research Database

Objectives1. To develop new photoactive materials and fabricate demonstration QD (quantum dot) solar cells. This will be achieved by:~%~1.1. Materials preparation and characterisation of QD/polymer systems~%~1.2. Optimising structures of QDs, nanorods and polymer for quantum yield and charge transfer~%~1.3 Fabricating demonstration QD/polymer solar cells and measuring power conversion efficiencies~%~2. To demonstrate multiexciton generation (MEG) and harvesting within nanostructured QDs. This will involv [continued...]DescriptionWidespread implementation of photovoltaic electricity to meet changing energy demands requires a step-change in the cost of photovoltaic power. This proposal assembles a consortium of chemists, physicists, materials scientists and electrical engineers from The University of Manchester and Imperial College London to address this need through the development of new low-cost, high-efficiency, demonstration solar cells for micro-generation.We ...

2010-01-30

351

Hawaii technology utilization experiment

GENERIC ENZYME TECHNOLOGY FOR IMPROVED PAPER RECYCLING

A one-year technology-transfer project involving ERDA installations and Hawaii consisted of sending teams from the Lawrence Livermore Laboratory on week-long field trips every two months to test the effectiveness of different methods of transferring technology information from federal sources to civilian clients. The team was questioned primarily on non-energy matters, and the energy questions asked related mostly to individuals or small industries. The team responed to all questions and found that a wide range of knowledge was more effective than having a sequence of experts. Hawaiians considered current major ERDA projects to be irrelevant to their needs. The team was most successful on a one-to-one basis because large groups and state agencies tend to be more policy- than action-oriented. Personal followup was considered essential. The team also learned that their visits generated ten times as many inquiries as were received unsolicited by the laboratory. Most inquiries involved ...

1976-12-08

352

Environmental Research Database

Objectives- Investigate the potential for the use of enzymes to bring about improvements in the recycling of recovered waste paper sources~%~~%~- Optimise enzyme formulations and process conditions to maximise benefits. - Produce recovered fibre at lower energy and chemical costs than is currently achievable using 'classical' de-inking techniques.~%~~%~- Improve recycled fibre quality and~%~~%~- All of the above will allow a greater use of recovered paper resources, which would otherwise be diposed of by [continued...]DescriptionThe project proposes to carry out an initial literature review to update the consortium on the currently available publications relating to the use of enzymes in de-inking.. This will be followed by an intensive laboratory study in an upgraded facility which will allow enzyme formulations and mechanisms to be studied. This work will also eliminate the need for an initial round of pilot ...

2003-01-05

353

Costs of lithium-ion batteries for vehicles

Continuation application for the Amarillo National Resource Center for Plutonium, a higher education consortium consisting of Texas A and M University, Texas Tech University, and the University of Texas at Austin

One of the most promising battery types under development for use in both pure electric and hybrid electric vehicles is the lithium-ion battery. These batteries are well on their way to meeting the challenging technical goals that have been set for vehicle batteries. However, they are still far from achieving the current cost goals. The Center for Transportation Research at Argonne National Laboratory undertook a project for the US Department of Energy to estimate the costs of lithium-ion batteries and to project how these costs might change over time, with the aid of research and development. Cost reductions could be expected as the result of material substitution, economies of scale in production, design improvements, and/or development of new material supplies. The most significant contributions to costs are found to be associated with battery materials. For the pure electric vehicle, the battery cost exceeds the cost goal of the US Advanced Battery Consortium ...

2000-08-21

354

Containment of genetically engineered organisms after application to subsurface environments. Technical completion report

This report describes the 5 tasks to be covered under this project and compiles budget information. Task 1 is to establish a Plutonium Information Resource, which has been established in Amarillo, Texas. Task 2, Advisory Functions, coordinates studies and activities relating to the disposition of excess weapons-grade plutonium. Task 3, Environmental, Public Health, and Safety, supports soil remediation activities. Task 4, Education and Outreach, is supporting four programs: K--12 education improvement in science and math courses; Academic intervention to identify and encourage high ability high school and middle school students with potential to become scientists and engineers; Graduate education evaluation; and Public outreach programs. Task 5, Plutonium and other Materials Studies, is currently funding two projects for the disposition of high explosives: a feasibility study of burning a mixture of high explosives and other materials in a commercial coal-fired power plant and ...

1995-06-29

355

Aerocapacitor commercialization plan

The feasibility of containing genetically engineered bacteria with enhanced dehalogenating properties for in situ bioremediation was investigated. (1) An agarose matrix microbead protocol and a detection system for contained microorganisms or DNA were developed. Multiplex Polymerase Chain Reaction (PCR) allowed tracking of a consortium of encapsulated organisms or several gene targets from a single species. Gene sequences encoding the enzymes responsible for initiating the biodegradation of toluene, octane, and 2,4-D were detected by multiplex PCR and nucleic acid probes from similar to 1-10 biodegradative cells/g soil. Improved DNA extraction methods resulted in PCR reactions detecting similar to 6 cells/g soil. (2) The pcpB gene (for the broad-spectrum detoxicant pentachlorophenol (PCP) hydroxylase) isolated from Flavobacterium sp. strain ATCC 39723 was used in attempts to develop an improved dehalogenating recombinant microorganism for containment experiments.

1993-06-01

356

ANL`s electric vehicle battery activities for USABC. Progress report, April--September 1992

The purpose of the Power-One Aerocapacitor Commercialization Plan is to communicate to members of management and to all employees the overall objectives of the corporation. Power-One, Inc., has participated in a US Federal Government Technology Reinvestment Project (TRP), entitled {open_quotes}Advanced Power Conversion based on the Aerocapacitor{close_quotes}: the project is a group effort, with Lawrence Livermore National Labs, GenCorp/Aerojet, PolyStor Corp. (a start-up company), and Power-One forming the consortium. The expected resulting technology is the {open_quotes}Aerocapacitor{close_quotes}, which possesses much higher performance levels than the usual capacitors on the market today. Power-One hopes to incorporate the Aerocapacitor into some of its products, hence enhancing their performance, as well as market privately-labeled aerocapacitors through its distribution channels. This document describes the details of Power-One`s plan to bring to market and ...

1995-09-12

357

A microscale protein NMR sample screening pipeline

The Electrochemical Technology Program at Argonne National Laboratory (ANL) provides advanced battery R&D; technology transfer to industry; technical analyses, assessments, modeling, and databases; and independent testing and post-test analyses of advanced batteries. These capabilities and services are being offered to the US Advanced Battery Consortium (USABC) and Cooperative Research and Development Agreements (CRADA) are being negotiated for USABC-sponsored work at ANL. A small portion of DOE`s cost share for USABC projects has been provided to ANL to continue R&D and testing activities on key technologies that were previously supported directly by DOE. This report summarizes progress on these USABC projects during the period of April I through September 30, 1992. In this report, the objective, background, technical progress, and status are described for each task. The work is organized into the following task areas: 1.0 Lithium/Sulfide Batteries; 2.0 ...

1992-12-31

358

PT3. [SITE 2002 Section].

As part of efforts to develop improved methods for NMR protein sample preparation and structure determination, the Northeast Structural Genomics Consortium (NESG) has implemented an NMR screening pipeline for protein target selection, construct optimization, and buffer optimization, incorporating efficient microscale NMR screening of proteins using a micro-cryoprobe. The process is feasible because the newest generation probe requires only small amounts of protein, typically 30-200 ?g in 8-35 ?l volume. Extensive automation has been made possible by the combination of database tools, mechanization of key process steps, and the use of a micro-cryoprobe that gives excellent data while requiring little optimization and manual setup. In this perspective, we describe the overall process used by the NESG for screening NMR samples as part of a sample optimization process, assessing optimal construct design and solution conditions, as well as for determining protein ...

2010-01-01

359

caCORE version 3: Implementation of a model driven, service-oriented architecture for semantic interoperability.

This document contains 142 papers on PT3 (Preparing Tomorrow's Teachers to use Technology) from the SITE (Society for Information Technology & Teacher Education) 2002 conference. Topics covered include: a technology in urban education summit; student professional development; meeting NCATE (National Council of Teachers of English) standards; faculty use of WebCT; preparing teachers for the digital age; technology in K-8 multicultural classrooms; using immersive 360 degree images; consortium building; student evaluation; technology fellows; incentives that facilitate institutional change; impact of a temporary grant; a consortium for outstanding achievement in teaching with technology; changes implemented after technology professional development sessions; Web-based modules for teaching mathematics to minority students; student teaching technology sites; preservice teachers design technology-enhanced learning experiences; planning, ...

2002-03-01

360

Statistical measure of association between smoking and lung cancer in Abakaliki, Ebonyi State Nigeria.

One of the requirements for a federated information system is interoperability, the ability of one computer system to access and use the resources of another system. This feature is particularly important in biomedical research systems, which need to coordinate a variety of disparate types of data. In order to meet this need, the National Cancer Institute Center for Bioinformatics (NCICB) has created the cancer Common Ontologic Representation Environment (caCORE), an interoperability infrastructure based on Model Driven Architecture. The caCORE infrastructure provides a mechanism to create interoperable biomedical information systems. Systems built using the caCORE paradigm address both aspects of interoperability: the ability to access data (syntactic interoperability) and understand the data once retrieved (semantic interoperability). This infrastructure consists of an integrated set of three major components: a controlled terminology service ...

2007-04-02

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361

Prevention of lung cancer by remediation of residential exposure to radon daughters

The hazards of smoking in relation to lung cancer can never be over emphasized. In recent times shortly after Ebonyi State was created in 1996, the capital territory has increasingly been polluted by either quarry operators, motorcycle (Okada) riders or reckless cigarette smokers and bush burning. To investigate the havoc caused by all these on people, questionnaire was distributed among smokers and non smokers in various areas of specialization and habitations. In measuring the significance of association and the degree of association, a chi2 test and odds ratio method of analysis was employed. The result of the analysis showed that non-smokers do suffer lung cancer. It also revealed that the chances of a smoker to have lung cancer is 1.765 times higher than that of a non-smoker. Analysis also showed that lung cancer depends on age of smokers. It was later discovered that middle aged population are ...

2009-04-01

362

New dimensions in our understanding of the human health effects of environmental pollutants

The United States Bonneville Power Administration (BPA), as part of an energy conservation programme in the states of Washington, Oregon, Idaho, Wyoming, and Montana, has collected over 36,000 residential radon concentration measurements. Data were collected between 1983 and 1989 with ambient {alpha} etched track dosemeters. Based on the linear risk coefficient from the BEIR IV report for lifetime lung cancer in smokers and non-smokers, numbers of lung cancer cases attributable to radon exposure were predicted. Numbers of baseline lung cancer cases and numbers of these that were preventable by remediation were also estimated. Remediation to 10 pCi.1{sup -1}, to 4 pCi.1{sup -1}, and to outdoor levels were considered. With vital statistics data, results were extrapolated to populations in the states represented by the BPA data. Costs of remediation were estimated. Results were evaluated in terms of cost per ...

1991-01-01

363

Evaluation of Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in cervical cancer susceptibility

The term {open_quotes}hazardous{close_quotes} waste is used primarily in reference to potential hazards to human health and, to a lesser decree, hazards to wildlife and the ecosystem. Many of the chemicals associated with hazardous waste sites are also widely distributed throughout the environment; therefore, the health hazards associated with hazardous waste sites are not different from those associated with general environmental contamination. Until recently, it was generally assumed that cancer was the human disease of greatest concern associated with toxic chemicals. In fact, most governmental regulations related to exposure are designed on the basis of presumed cancer risks. Since the evidence that hazardous chemicals can cause cancer is strong, it is appropriate to be concerned about cancer risk. Recent evidence, however, has triggered a reevaluation of the assumption that only ...

1996-12-31

364

British Library Electronic Table of Contents (United Kingdom)

Cervical cancer is emerging as a leading cause of morbidity and mortality in women worldwide. Toll-like Receptor (TLR) gene polymorphisms may contribute to subsequent inter-individual variability in cancer susceptibility. The present study aimed to identify the role of TLR 3 (c.1377C/T) [rs3775290] and TLR 9 (G2848A) [rs352140] gene polymorphisms in the risk of developing cervical cancer in North India. Peripheral blood samples were collected from 200 histopathologically confirmed cervical cancer patients from North India and 200 unrelated, cancer-free, age-matched healthy female controls of similar ethnicity. Genomic DNA was extracted using the salting-out method, and genotyped for TLR 3 and TLR 9 using polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). O...

2011-01-01

365

Dietary Cholesterol and Prostate Cancer Risk: Inhibition of prostate Cancer in Rats by the Administration of some Antioxidants

Detection of mice lung cancer by neutron radiography

The present work was carried out to illuminate the relation between high cholesterol diet and incidence of prostate caner. Also, in this study, the effect of DHEA, selenium or oxygen therapy were tested in order to show to what extent they are valid to ameliorate the deleterious effects of prostate cancer. The obtained results revealed that prostate cancer caused a significant (p<0.01) elevation of TAP, PAP, PSA, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol and prostate COX-2, whereas, testosterone, free testosterone, DHEA-S, FT_4 and FT_3 were decreased significantly as compared with the corresponding levels in control rats in both normal and high cholesterol diet. Supplementation of DHEA, selenium or oxygen therapy ameliorated all variables recorded herein but, their values did not revert to normal. Any how, the results of this investigation showed that the above mentioned antioxidants possess potential benefits in ...

2009-07-01

366

A case study of trastuzumab treatment for metastatic breast cancer in pregnancy: fetal risks and management of cerebral metastases

Thermal neutron beam from the TNRF of JRR-3M was utilized for detection of mice lung cancer in vivo. Both the static and real-time neutron imaging were tried. Very strong thermal neutron beam is necessary to detect lung cancers because small changes are hidden by the very large attenuation of thermal neutron beam by the hydrogens in the tissues. The detection was successfully performed. Especially, the Super Eye of Hamamatsu Photonics contributed very effectively. Bone marrows and cartilages were also shown clearly. If an efficient and compact neutron source will become available in future, this method will grow up as a powerful tool for biomedical application. (author).

1995-11-01

367

British Library Electronic Table of Contents (United Kingdom)

Trastuzumab increases survival amongst women with human epidermal growth factor receptor (HER)-2 receptor positive metastatic breast cancer, but maternal and fetal risks are associated with advanced disease and its treatment in pregnancy. We present a case of a primigravid with HER-2 positive metastatic breast cancer who received trastuzumab throughout pregnancy. She presented with cerebral metastases, requiring surgical decompression and resection. Reversible oligohydramnios developed during pregnancy. Fetal safety data on trastuzumab in pregnancy is limited, but case reports suggest a recurring pattern of (mostly reversible) oligohydramnios.

2011-01-01

368

[caCORE: core architecture of bioinformation on cancer research in America].

What Is Most Important to Patients when Deciding about Colorectal Screening?

A critical factor in the advancement of biomedical research is the ease with which data can be integrated, redistributed and analyzed both within and across domains. This paper summarizes the Biomedical Information Core Infrastructure built by National Cancer Institute Center for Bioinformatics in America (NCICB). The main product from the Core Infrastructure is caCORE--cancer Common Ontologic Reference Environment, which is the infrastructure backbone supporting data management and application development at NCICB. The paper explains the structure and function of caCORE: (1) Enterprise Vocabulary Services (EVS). They provide controlled vocabulary, dictionary and thesaurus services, and EVS produces the NCI Thesaurus and the NCI Metathesaurus; (2) The Cancer Data Standards Repository (caDSR). It provides a metadata registry for common data elements. (3) Cancer Bioinformatics Infrastructure Objects ...

2006-04-18

369

Updates on Osteonecrosis of the Jaw

BACKGROUNDColorectal cancer (CRC) screening can be administered through tests with varied characteristics and is a preference-sensitive decision.OBJECTIVETo...Full Text Available

2010-07-01

370

Tumor necrosis factor-? is associated with positive lymph node status in patients with recurrence of colorectal cancer?indications for anti-TNF-? agents in cancer treatment

Purpose of reviewOsteonecrosis of the Jaw (ONJ) in an uncommon condition noted to occur in patients with cancer receiving intravenous bisphosphonates. The etiology...Full Text Available

2010-09-01

371

British Library Electronic Table of Contents (United Kingdom)

Introduction The progressive growth of malignancies is accompanied by a decline in the immune response through mechanisms which are poorly understood. Apoptosis and induction of inflammation by tumor released cytokines as tumor escape mechanisms have been proposed to play an important role in colorectal carcinogenesis. Methods Expression of Tumor necrosis factor-alpha (TNF-?) was analyzed in colorectal cancer specimen and the cancer cell line HT-29 by immunohistochemistry and RT-PCR. TNF-? expression on protein and mRNA level were correlated with clinical characteristics and impact on survival. TNFR-1 was co-labelled with TNF-? and CD8+ cytotoxic T cells in immunofluorescence double staining experiments. Results: 94% (n?=?98/104) of the patients with CRC expressed TNF-?. High TNF-? express...

2011-01-01

372

Towards a more functional concept of causality in cancer research

The pros and cons of phytoestrogens

Advances in molecular technologies challenge the different concepts of causality in biology, epidemiology and multistage mathematical models. The lack of integration of the different aspects of causality...Full Text Available

373

The multiple roles of autophagy in cancer

Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast cancer,...Full Text Available

2010-10-01

374

The Importance of Mitochondrial DNA in Aging and Cancer

Autophagy is an evolutionarily conserved, catabolic process that involves the entrapment of cytoplasmic components within characteristic vesicles for their delivery to and degradation within lysosomes....Full Text Available

2011-07-01

375

Telomeric recombination induced by dysfunctional telomeres

Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue...Full Text Available

376

Telomeres in cancer and ageing

Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer...Full Text Available

2011-01-15

377

Telomeres and telomerase in cancer

Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG repeats) bound to an array of specialized...Full Text Available

2011-01-12

378

Spectral Analysis of Breast Cancer on Tissue Microarrays ...

Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic events commandeer many signaling pathways that cooperate to endow aspiring...Full Text Available

2010-01-01

379

Site-Specific Methylation of the Promoter Alters Deoxyribonucleic Acid-Protein Interactions and Prevents ...

... Although cytologic evaluation of urine specimens is a standard Cesar Angeletti, MD ... 3. Rodriguez-Alonso A, Pita-Fernandez S, Gonzalez-Carrero J, ...

2005-04-01

380

Sirtuins, Bioageing, and Cancer

... and R. L. Momparler. DNA methylation of retinoic acid receptor beta in breast cancer and possible therapeutic role of ... ...

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381

Role of early phase helical CT images in the evaluation of wall invasion of colorectal cancer. Pathological correlation

The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function,...Full Text Available

382

Regulation of Senescence in Cancer and Aging

The usefulness of helical CT early phase images optimized by the SmartPrep method for evaluation of wall invasion by colorectal cancer was investigated. Between August 1997 and September 1998, CT was performed to evaluate the primary tumor and local extension in 10 consecutive patients with colorectal cancer confirmed by barium enema- and/or colonoscopy. Early-phase images were acquired by using SmartPrep application software. This method allows the optimal scan delay time to be obtained by continuous monitoring of increases in CT values after injection of contrast medium. Sections of the surgical specimens, close to the same plane as the CT images, and of the same slice thickness, were analyzed histopathologically. All 10 cancers, regardless of size, showed strong enhancement on the early-phase images (81.4-112 HU, mean: 95.1 HU). The strongly enhanced image areas on CT corresponded to the primary ...

2000-02-01

383

Recent advances in the management of carcinoma of the rectum

Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically...Full Text Available

384

In the last two decades rectal cancer has changed from a surgically managed disease into a multidisciplinary treatment model resulting in considerable improvements in the survival and outcome. This...Full Text Available

385

Ras history

Radiolabelled peanut lectin for the scintigraphy detection of cancer

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an...Full Text Available

2010-07-01

386

Prognostic Factors for Failure after Prostatectomy

To investigate the role of intravenously administered, radioiodinated peanut lectin ("1"3"1I-PNA) in the non-invasive detection of cancer, the pharmacokinetics and scintigraphic distribution of this novel tumor-seeking compound were studied in 8 patients with metastatic cancer of the colon, breast or lung. Scintigraphic localization of "1"3"1I-PNA was apparent at certain anatomical sites of known metastases in 2 patients and in a further 2 patients an adjacent malignant pleural effusion was visualized. The rapid clearance of radioactivity from the whole body and plasma with marked renal concentration and rapid urinary excretion of significant amounts of intact "1"3"1I-PNA (mol.wt. 107,000,pI 5.95) implied that this molecule was excreted selectively by the renal tubules. PNA or other lectins may find a role in the scintigraphic detection of selected types of cancer. (author).

1984-01-01

387

Primary lymphoma of the brain: MedlinePlus Medical Encyclopedia

Several randomized studies have been completed in prostate cancer that show a benefit to immediate postoperative treatment in patients undergoing prostatectomy. In one of the studies, there was even...Full Text Available

388

Preclinical Models for Neuroblastoma: Establishing a Baseline for Treatment

brain Printer-friendly version Email this page to a friend Share Primary lymphoma of the brain is cancer of the lymph cells that starts in the brain. Causes The cause of primary...

2011-10-13

389

Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk

BackgroundPreclinical models of pediatric cancers are essential for testing new chemotherapeutic combinations for clinical trials. The most widely used ...Full Text Available

390

DEFF Research Database (Denmark)

Colorectal cancer is the third most common malignant tumor and the fourth-leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in depth analysis of inter-individual differences in fatty acid metabolizing genes as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. 392 single nucleotide polymorphisms were selected using pairwise tagging with an r(2) cutoff of 0.8 and a minor allele frequency of >5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype ...

2010-01-01

391

Peritonectomy procedures.

Oral Exposure to Bisphenol A Increases Dimethylbenzanthracene-Induced Mammary Cancer in Rats

OBJECTIVE: New surgical procedures designed to assist in the treatment of peritoneal surface malignancy were sought. BACKGROUND: Decisions regarding the treatment of cancer depend on the anatomic location...Full Text Available

1995-01-01

392

Novel Magnetic Fluids for Breast Cancer Therapy

BackgroundBisphenol A (BPA) is widely used in the manufacture of polycarbonate plastics, including infant formula bottles.ObjectivesBased on the...Full Text Available

2009-06-01

393

Novel Cytotoxic Vectors Based on Adeno-Associated Virus

... metal-oleate complexes. At this point, this method has been reported only for iron nanoparticles [15]. We have demonstrated ...

2008-01-01

394

Monoclonal antibodies: new agents for cancer detection and targeted therapy

positive primary PymT breast cancer cells in primary co-cultured tumor tissue, suggesting target specificity of

395

Molecular marks for epigenetic identification of developmental and cancer stem cells

Antibodies directed against markers on cancer cells are gaining in importance for the purpose of targeting diagnostic and therapeutic agents. In the past, this approach has had very limited success principally because the classical methods for producing antibodies from blood serum of animals immunized with cancer cells or extracts were unsatisfactory. The situation has changed dramatically since 1975 following the design of procedures for 'immortalizing' antibody-producing cells (lymphocytes) by fusing them with cultured myeloma cells to form hybridomas which continuously secrete antibodies. Since these hybridomas produce antibodies coded for by a single antibody-producing cell, the antibodies are called monoclonal. Building on these advances in biomedical research, it is now possible to reproducibly manufacture monoclonal antibodies on a scale suitable for use in cancer detection and therapy.

396

British Library Electronic Table of Contents (United Kingdom)

Epigenetic regulations of genes by reversible methylation of DNA (at the carbon-5 of cytosine) and numerous reversible modifications of histones play important roles in normal physiology and development, and epigenetic deregulations are associated with developmental disorders and various disease states, including cancer. Stem cells have the capacity to self-renew indefinitely. Similar to stem cells, some malignant cells have the capacity to divide indefinitely and are referred to as cancer stem cells. In recent times, direct correlation between epigenetic modifications and reprogramming of stem cell and cancer stem cell is emerging. Major discoveries were made with investigations on reprogramming gene products, also known as master regulators of totipotency and inducer of pluoripotency, na...

2011-01-01

397

Modeling survival in colon cancer: a methodological review

Management of Concomitant Cancer and Abdominal Aortic Aneurysm

The Cox proportional hazards model is the most widely used model for survival analysis because of its simplicity. The fundamental assumption in this model is the proportionality of the hazard function....Full Text Available

398

Liver Carcinogenesis Unit

Background. The coexistence of neoplasm and abdominal aortic aneurysm (AAA) presents a real management challenge. This paper reviews the literature on the prevalence, diagnosis,...Full Text Available

399

Lipiodol solution of a lipophilic agent, {sup 188}Re-TDD, for the treatment of liver cancer

The Liver Carcinogenesis Section uses the modern technologies of molecular biology, cell biology, protein chemistry and genetics to investigate the biochemical and genetic pathways involved in human liver cancer.

400

Lack of Association of the Genotype in the GNAS Fok I Polymorphism and Prostate Cancer

Radiolabeled lipiodol has been used for targeting liver cancer. We developed a lipiodol solution of {sup 188}Re-TDD (2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol) and investigated its feasibility for the treatment of liver cancer. The lipiodol solution of {sup 188}Re-TDD was well-retained in the lipiodol phase in vitro. After injection through the tail veins of mice, high lung-uptake was investigated which is evidence of embolizing activity. We also found high accumulation in hepatoma after injection through the hepatic arteries of hepatoma-bearing rats. In conclusion, the lipiodol solution of {sup 188}Re-TDD is a promising agent for liver cancer therapy.

2001-02-01

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401

British Library Electronic Table of Contents (United Kingdom)

Abstract Background: G proteins are ubiquitously expressed signal transduction proteins playing a key role in multiple signal transduction pathways. The Gas subunit has been considered as an apoptosis factor. In this study the role of GNAS T393C genotypes of the GNAS gene encoding Gas was analyzed for its influence on the development and progression of prostate cancer. Methods: Genotyping of the GNAS T393C polymorphism in 196 prostate cancer patients and 200 healthy controls was performed by DNA extraction followed by PCR and restriction analysis. Results: We observed no evidence of effects related to GNAS T393C genotype as demonstrated by a comparison of the genotype distribution in prostate cancer patients and healthy controls, the genotype distribution dependent on grade of the primary ...

2011-01-01

402

Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation.

Interdisciplinary Breast Cancer Training Program

The need for agents designed to modify immune response in the treatment of patients with viral infection, immunodeficiency, or cancer prompted the present study on the mechanisms of action of isoprinosine,...Full Text Available

1976-02-01

403

Growth of mammary epithelial cells in breast-cancer biopsies correlates with EGF binding

... equal volume of vehicle, sesame oil only (n = 10). At 75 days 2.0. ... thracene IDMBA) and sesame oil were purchased from Sigma ...

2005-09-01

404

Four faces of cellular senescence

In order to understand the role of EGF in the development of human mammary epithelial tissue, we analysed the binding of /sup 125/I-EGF to sections of breast cancer biopsies. A mean specific /sup 125/I-EGF binding of 8.9 fmol per mg protein was estimated in thin sections of 17 breast cancer biopsies. Microautoradiographic analysis of /sup 125/I-EGF binding to the tissue sections was applied to demonstrate that EGF was bound predominantly to mammary epithelial cells. The binding was clearly correlated to the number of mitoses of mammary epithelial cells in the same samples. The highest EGF binding and proliferation rates were found in biopsies from breast cancer with axillary lymph-node metastases.

1987-03-15

405

Effect of Smoking Scenes in Films on Immediate Smoking

Cellular senescence is an important mechanism for preventing the proliferation of potential cancer cells. Recently, however, it has become apparent that this process entails more than a simple cessation...Full Text Available

2011-02-21

406

Effect of COX-2 (PGE2) and IL-6 on Prostate Cancer Bone ...

BackgroundThe National Cancer Institute has concluded that exposure to smoking in movies causes adolescent smoking and there are similar results for young adults.Full Text Available

2010-04-01

407

EMFs: cutting through the controversy.

... of the AR (25). Dihydrotestosterone increases Wnt signaling activity in preosteoblasts. Functional interactions between ...

2008-02-02

408

Dysregulation of the mevalonate pathway promotes transformation

SOME SCIENTISTS ALLEGE that exposure to electric and magnetic fields generated by electric power delivery systems is responsible for certain cancers (particularly among children), reproductive dysfunction,...Full Text Available

1996-05-01

409

Distribution of domestic radon concentrations and lung cancer mortality in England and Wales

The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood. With a clear understanding...Full Text Available

2010-08-24

410

Using aggregate data for the counties of England and Wales, a negative association is found between mean radon concentrations in dwellings and lung cancer standardised mortality ratios, when regional smoking variations, diet variations, social class variations and population density are controlled. Cornwall and Devon have the highest mean domestic radon gas concentrations, yet the number of lung cancer deaths there was within the range to be expected from relationships not involving radon observed in the rest of the country. While high values of radon exposure appear to concentrate in particular localities, the variations in lung cancer mortality between districts in Cornwall and Devon are small. These findings do not refute the linear exposure-risk hypothesis, but the evidence suggests that relatively few, if any, radon related deaths were associated with the dwellings where radon gas concentrations exceed the recommended ...

1988-01-01

411

Colonoscopy

Cell proliferation and chemical carcinogenesis: symposium overview.

... experts agree-- a colonoscopy is the most accurate test to detect the cancer, but because of cost ... method. Dr. Randall Burt: Colonoscopy is the best test. The question is therefore shouldn't everyone, since ...

412

Carcinogens and cancers in freshwater fishes.

Cancer, by definition, is a proliferative disease. The fundamental scientific issue explored at the international symposium "Cell Proliferation and Chemical Carcinogenesis" was the impact of chemically...Full Text Available

1993-12-01

413

Cancer-cell-specific cytotoxicity of non-oxidized iron elements in iron core-gold shell NPs

Epizootics of neoplasms in freshwater fish species are considered in relation to circumstantial and experimental evidence that suggest that some epizootics of neoplasia of hepatocellular, cholangiocellular,...Full Text Available

1991-01-01

414

British Library Electronic Table of Contents (United Kingdom)

Gold-coated iron nanoparticles (NPs) selectively and significantly (P <0.0001) inhibit proliferation of oral- and colorectal-cancer cells in vitro at doses as low as 5 mg/mL, but have little adverse effect on normal healthy control cells. The particle treatment caused delay in cell-cycle progression, especially in the S-phase. There was no significant difference in the NP uptake between cancer and control cells, and cytotoxicity resulted primarily from the iron core, before oxidation, rather than from the Fe ions released from the core. In contrast with magnetic NPs that usually serve as drug carriers, diagnostic probes or hyperthermia media, the iron, before oxidation, in the NPs selectively suppressed cancer cell growth and left healthy control cells unaffected in vitro and in vivo. This...

2011-01-01

415

Cancer gene discovery in mouse and man

AbstractThe elucidation of the human and mouse genome sequence and developments in high-throughput genome analysis, and in computational tools, have made it possible to profile entire...Full Text Available

2009-12-01

416

Breast Cancer Treatment

Body mass index and risk of colorectal cancer in Chinese Singaporeans

... mammography or on ultrasound but not found on physical examination, we consider them non-palpable or not ... lot of this. We send every patient for physical therapy, no matter what type of reconstruction we ...

417

British Library Electronic Table of Contents (United Kingdom)

AbstractBACKGROUND: The authors chose to examine the association between body mass index (BMI) and incident colorectal cancer across the spectrum of BMI, including underweight persons, because detailed prospective cohort data on this topic in Asians is scarce, as is data on underweight persons (BMI, <18.5 kg/m2) in any population. METHODS: Analysis of the Singapore Chinese Health Study included 51,251 men and women aged 45-74 years enrolled in 1993-1998 and followed through 2007. Incident cancer cases and deaths among cohort members were identified through record linkage, and 980 cases were identified. Cox regression models were used to investigate the association of baseline BMI with risk of incident colorectal cancer during a mean of 11.5 years of follow-up. RESULTS: A significant, U-sha...

2011-01-01

418

Attributes of Interactive Online Health Information Systems

Arterial and Venous Thrombosis in Cancer Patients

The development of online communication systems related to prevention, decision making, and coping with cancer has outpaced theoretical attention to the attributes that appeal to system...Full Text Available

419

Antitumor Activity of Noscapine in Combination with Doxorubicin in Triple Negative Breast Cancer

The most frequent ultimate cause of death is myocardial arrest. In many cases this is due to myocardial hypoxia, generally arising from failure of the coronary macro- and microcirculation to deliver...Full Text Available

420

Anesthetic considerations of central airway obstruction

BackgroundThe aim of this study was to investigate the anticancer activity and mechanism of action of Noscapine alone and in combination with Doxorubicin against triple negative...Full Text Available

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

Adenopathies in lung cancer: a comparison of pathology, Computed Tomography and endoscopic ultrasound findings

Central airway obstruction (CAO) is a serious presentation of lung cancer and associated chest diseases. It presents a real challenge to the anesthesiologist because usually the patient admitted to...Full Text Available

2011-07-01

422

APOPTOSIS BY DIETARY AGENTS FOR PREVENTION AND TREATMENT OF CANCER

A prospective comparative study with pathology was performed to assess the clinical value of Computed Tomography (CT) and endoscopic ultrasound (EUS) for nodal staging in lung cancer. A total of 329 nodal stations were dissected or sampled and 755 lymph nodes were examined at histology. On a pre-station basis, CT had greater sensitivity (74%) than EUS (56%), but EUS was more specific (83% versus 93%). The accuracy rates of the two techniques were similar. In conclusion, endoscopic ultrasound should be part of a routine preoperative diagnostic approach to non-small-cell lung cancer., because of its high specificity. Results can be improved when EUS and CT are combined., which suggests that these imaging modalities should be used together in selected patients for the noninvasive staging of non-small-cell lung cancer to identify local lymphatic spread.

1999-01-01

423

A Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients With Advanced Solid Tumors and Metastatic Brain Cancer

The role of apoptosis or programmed cell death in the regulation of development and maintenance of homeostasis in multicellular organisms is well established. During the last decade, naturally...Full Text Available

2008-12-01

424

Wetlands of Argonne National Laboratory-East DuPage County, Illinois

Advanced Solid Tumors With and Without Brain Metastases

2010-06-03

425

The Spratlys: Islands nowhere else? Energy resources as a conflict factor and co-operation factor in East Asia; Die Spratlys: Inseln im Nirgendwo? Energieressourcen als Konflikt- und Kooperationsfaktor in Ostasien

Jurisdictional wetlands of the Argonne National Laboratory-East (ANL-E) site in DuPage County, Illinois, were delineated in the summer and autumn of 1993 in accordance with the 1987 US Army Corps of Engineers methodology. Potential wetland sites with an area greater than 500 m{sup 2} (0.05 ha [0.124 acre]) were identified for delineation on the basis of aerial photographs, the DuPage County soil survey, and reconnaissance-level field studies. To qualify as a jurisdictional wetland, an area had to support a predominance of hydrophytic vegetation as well as have hydric soil and wetland hydrology. Thirty-five individual jurisdictional wetlands were delineated at ANL-E, totaling 180,604 m{sup 2} (18.1 ha [44.6 acres]). These wetlands were digitized onto the ANL-E site map for use in project planning. Characteristics of each wetland are presented -- including size, dominant plant species and their indicator status, hydrologic characteristics (including water source), ...

1994-03-01

426

Shallow hydrothermal regime of the East Brawley and Glamis known geothermal resource areas, Salton Trough, California

In the contribution under consideration, the author reports on the energy resources as a conflict factor and co-operation factor in East Asia on the basis of the Spratly islands. The main aspects of this contribution are: topography of the Spratly islands; history and actual claims; evaluation of the claims; strategic significance of the islands; resources of oil and natural gas as a conflict factor; resources of oil and natural gas as a co-operation factor. The resources of oil and natural gas have intensified the conflict around the Spratly islands in the last few decades. Due to the unsettled situation relating to international law six countries could claim the potentially energy-rich area having a geo-strategic instrument of power. Due to a treaty and due to the new common research studies of the neighbouring countries a phase of stability can be expected. The increasing involvement of China in the international economic structures suggests a military solution ...

2006-07-01

427

Failure analysis report: Heat exchanger tubes geothermal binary power plant, Magma Electric Company, East Mesa, California

Thermal gradients and thermal conductivities were obtained in real time using an in situ heat-flow technique in 15 shallow (90 to 150 m) wells drilled between Brawley and Glamis in the Imperial Valley, Southern California. The in situ measurements were supplemented by follow-up conventional temperature logs in seven of the wells and by laboratory measurements of thermal conductivity on drill cuttings. The deltaic sedimentary material comprising the upper approx. 100 m of the Salton Trough generally is poorly sorted and high in quartz resulting in quite high thermal conductivities (averaging 2.0 Wm/sup -1/ K/sup -1/ as opposed to 1.2 to 1.7 for typical alluvium). A broad heat-flow anomaly with maximum of about 200 mWm/sup -2/ (approx. 5 HFU) is centered between Glamis and East Brawley and is superimposed on a regional heat-flow high in excess of 100 mWm/sup -2/ (> 2.5 HFU). The heat-flow high corresponds with a gravity maximum and partially with a minimum in ...

1981-01-01

428

Detachment tectonics in Sadlerochit and Shublik mountains and applications for exploration beneath Coastal Plain, Arctic National Wildlife Range, Alaska

Radian received twelve sections of heat exchanger tubing from the Magma Electric Company's 10MW(e) East Mesa binary geothermal power plant. Three tube sections were received from each of four shell and tube heat exchangers (HX1, Hx6, HX8, and Hx10) of the isobutane vaporizer train. All samples were taken from the upper few rows of tubes. Two months later, four more tube sections were received. These four sections were taken from the lower rows of heat exchangers 1, 6 (two sections), and 10. Radian was requested to investigate the cause of severe pitting failure of these heat exchanger tubes. This report is part of a continuing DOE effort to gain insight into the service life of component materials employed in geothermal energy utilization.

1982-05-01

429

Community structure and temporal variability of juvenile fish assemblages in natural and replanted mangroves, Sonneratia alba Sm., of Gazi Bay, Kenya

Preliminary field investigations suggest three detachments in the Sadlerochit and Shublik Mountains: (1) the Kingak Shale, (2) along the pre-Mississippian unconformity, and (3) within the pre-Mississippian basement. Thrust faults that cut the overlying Mississippian and younger section have horizontal displacements of 5-8 km and emplace pre-Mississippian rocks on Cretaceous strata. A large number of smaller thrust faults, responsible for deformation of the pre-Mississippian surface contribute to shortening. Structures involving the pre-Mississippian section trend east-west whereas earlier formed structures related to the Kingak Shale decollement trend east-northeast-to west-southwest. Possible exploration leads beneath the coastal plain include: (1) large, broad, basement involved structural culminations that may have subtle seismic expressions and (2) pre-Mississippian potential reservoirs thrust over Cretaceous source beds. Possible ...

1985-04-01

430

British Library Electronic Table of Contents (United Kingdom)

The juvenile fish community associated with natural, degraded and replanted Sonneratia alba mangroves in Gazi Bay was sampled during the South East and North East monsoons between April 2002 and June 2003. A total of 1800 individuals belonging to 49 taxa and 34 families were collected from the intertidal forest using stake nets. Fish abundance ranged from 0.93+-0.20ind. m-2 (SEM02) to 1.16+-0.18ind. m-2 (SEM03) between seasons and between 0.54+-0.07ind. m-2 and 1.64+-0.33ind. m-2 for individual sites across seasons. Five taxa accounted for approximately 70% of the total fish abundance, with Gobidae and Gerres oyena dominating. ANOSIM revealed seasonal differences in fish species composition and abundance (p=0.01) due to fluctuating abundances of primarily Terapon sp. and Thryssa sp. The ma...

2007-01-01

431

Chemometric source identification of PCDD/Fs and other POPs in sediment cores of North-East Germany

Bison basin, central Wyoming - geologic overview

A broad range of persistent organic pollutants (POPs) and selected heavy metals has been analysed in sediment cores of North-East Germany. The pollutants analysed include polychlorinated dioxins and furans (PCDD/Fs), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), several pesticides (DDT, HCH, CBz) and its metabolites as well as selected heavy metals. The sediment cores were sampled at five locations, reflecting a range of anthropogenic influences and background contamination: Arkona Basin (AK) representing a remote marine site, Lake Bugsin (BS) a background location only with atmospheric deposition, Lake Quenz (QS) close to the industrial city of Brandenburg, Teltowkanal (TK) in the suburban-industrial zone of Berlin and Lake White (WS) in the centre of Berlin. The age of the lower part of the AK, BS and TK cores were dated at 100-150 years. Results of selected pollutants (PCDD/Fs) have been presented earlier, focussing on the depth ...

2004-09-15

432

Thrombolysis: attempting to reduce postcode prescribing in Scotland?

The northeastern part of the Great Divide basin is a separate, unique, and until recently, little-explored subbasin sometimes called the Bison basin. It is bounded by the Wind River Mountains, Sweetwater-Granite Mountain foreland uplift, Lost Soldier-Wertz structure, and a little-studied very positive east-west structural arch approximately coincident with the Sweetwater-Fremont county line. A comprehensive seismic, Landsat, and subsurface geologic examination or, better, dissection of the Bison basin was initiated in 1978. Numerous oil and gas prospects were delineated by this study. Since this small, 12 by 40 mi (19 by 64 km) basin is bordered by known reserves of 260 million bbl of oil and 90 million bcf of gas, these prospects proved to be a popular target of the drill bit. At least one of these prospects appears to be productive; others are currently being drilled. The presence of major east-west wrench faults, a well-documented foreland ...

1984-07-01

433

Test coking of charges containing coal from the Western Donbass and the Karaganda coalfield

The literature is littered with reports presenting the proportion of patients admitted with ischaemic stroke receiving thrombolysis. This gives some measure of activity and the efficiency of prehospital and hospital triage. Some stroke centres have reported rates of thrombolysis as high as 20%, but without knowing the population that such services serve, these proportions do not indicate how well or equitably the treatment is being delivered. Here, we explore various metrics to monitor our efforts to provide equitable access to stroke thrombolysis in Lothian, a region in the South East of Scotland. PMID:21086712

2010-12-01

434

Rocket borne solar eclipse experiment to measure the temperature structure of the solar corona via lyman-. cap alpha. line profile observations

In recent years the feedstock base of the coking plants in the South has been significantly degraded: the charges contain an increased quantity of gas coal and coal from coalfields in the East are being included. Certain plants in the Ukraine receive coal from the Kuznetsk, Pechora and Karaganda coalfields. Addition of these coal types in the charges of plants in the South is expected to continue in the future. Their efficient utilization requires careful investigation of the new charges in order to determine the optimal composition and to produce blast furnace coke meeting modern specifications.

1981-01-01

435

A rocket borne experiment to measure the temperature structure of the inner solar corona via the doppler broadening of the resonance hydrogen Lyman-..cap alpha.. (lambda1216A) radiation scattered by ambient neutral hydrogen atoms was attempted during the 16 Feb 1980 solar eclipse. Two Nike-Black Brant V sounding rockets carrying instrumented payloads were launched into the path of the advancing eclipse umbra from the San Marco satellite launch platform 3 miles off the east coast of Kenya.

1981-01-01

436

Regional paths diverge

New Alberta coal mine gets green light

Over the last year, the energy industry firmly established itself as the premier borrowing sector in the international financial markets. While Europe and North America's major energy companies continue to access the loan market as their main source of financing, with a steady flow of new international borrowings, their peers from other areas of the world, such as Latin America and the Middle East, are in the process of positioning themselves in the market as regular borrowers and have become an important new source of fee income for industry's bankers. (Author).

1992-06-01

437

Modernization and retrofit concept for the Umm Al Nar East combined cycle power station; Massgeschneiderte Modernisierung und Nachruestung des Kombikraftwerks Umm Al Nar East

McLeod River Coal Ltd., a wholly owned subsidiary of Manalta Coal Ltd., has received Alberta Energy Resources Conservation Board approval to establish an open pit coal mine and plant in the northwest portion of the Coalspur field, east of Hinton. McLeod proposes to produce up to 4.2 million tonnes/year of thermal coal for 40 years, starting in 1985. The commercial viability of the project must be assessed before construction starts at the McLeod River site. The Board's ruling is subject to provincial cabinet approval.

1983-02-01

438

Measuring preferences for low-carbon energy technologies in South-East England: the case of electricity generation

Preserving customers` investments in capital goods is one of the strategic market services offered by ABB, and to this end the company has developed project-specific retrofit concepts especially for older power generation plant. A prime example of such a modernization is the Umm Al Nar East (UANE) combined cycle power station in Abu Dhabi, UAE. UANE has two gas turbines of type GT13D, which together generate 140 MW of electrical energy, and heat-recovery boilers which supply steam to a seawater desalination plant with a capacity of 80 million liters of drinking water per day. After almost 20 years in operation, UANE is being modernized. To address the owner`s concerns and minimize plant downtime, ABB has introduced Service, Operation and Rehabilitation (SOR) Key Account Management for Abu Dhabi. In the first phase of the modernization project, the static starting equipment was upgraded and the mechanical turbine governor replaced by the EGATROL electro-hydraulic ...

1998-05-01

439

GT13E gas turbines to power Killingholme A GTCC [gas turbine combined-cycle] plant

This paper presents a survey on public preferences in SE England for the use of wind, biomass and nuclear power in electricity generation. Using a labelled CE the perceived importance (value) to the public of distance and the energy options' impacts on biodiversity, emissions, land occupation and household cost was explored. Results suggest that impacts, technology name, demographic characteristics, attitudes towards the environment, knowledge and experience with the technologies were significant choice determinants. Considering the current debate about the development of nuclear power and biomass in UK and worldwide, this survey provides an insight into the factors affecting public acceptability

2008-07-01

440

Findings of long-term SO/sub 2/ measurements in Stuttgart

National Power is building its first gas turbine combined cycle power station at Killingholme, situated to the south of the River Humber in the East of England. NEI ABB Gas Turbines Limited was awarded the turnkey contract in July 1990 to build a nominal 650 MW combined cycle power station based around three Asea Brown Boveri GT13E gas turbines. The project is outlined in this article. The plant is due for completion in July 1993. (author)

1993-01-01

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441

Development of Tsunami PSA method for Korean NPP site

SO/sub 2/ concentrations in the Stuttgart air have been measured continuously since 1965. The two measuring points were located at the bottom of the Stuttgart city basin and 900 m east on the side of one of the surrounding hills. Long-term curves of pollutant loads have been established in consideration of meteorological parameters, as well as curves showing the average daily, weekly, and yearly pollution. The information thus gained may help to plan air pollution abatement measures in city planning.

1982-02-01

442

Argonne National Laboratory-East evolution of solid waste management

A methodology of tsunami PSA was developed in this study. A tsunami PSA consists of tsunami hazard analysis, tsunami fragility analysis and system analysis. In the case of tsunami hazard analysis, evaluation of tsunami return period is major task. For the evaluation of tsunami return period, numerical analysis and empirical method can be applied. The application of this method was applied to a nuclear power plant, Ulchin 56 NPP, which is located in the east coast of Korean peninsula. Through this study, whole tsunami PSA working procedure was established and example calculation was performed for one of real nuclear power plant in Korea

2010-10-01

443

miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NF?B1

The purpose of this report is to provide the reader with a basic understanding of Argonne National Laboratory`s current general refuse disposal and material recycling programs, how they were developed, and where they are going. In order to better understand the current situation, a brief description of the facilities past practices is explained. ANL is a multi-program research and development center owned by DOE and operated by the University of Chicago. Argonne`s primary facilities are on a 1,700 acre site, 27 miles southwest of Chicago. Fifty-seven major buildings house approximately 4,500 employees at the site.

1996-07-01

444

Treatment of uteral cancer by the brake irradiation (25 MeV)

The activation of nuclear factor-kappa B1 (NFκB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency of IR in lung cancer, we screened for...Full Text Available

2011-05-31

445

The tumor suppressor gene KCTD11^RENis regulated by Sp1 and methylation and its expression is reduced in tumors

The method of treatment of uteral cancer by the brake irradiation of 25 MeV betatrone using original devices which promote forming therapeutic figured bunches is presented. The binding of the protective blocks with a special adjusting frame within the aperture of the diaphragm provided for low relative entering dose which is the advantage of high energy irradiation bunch. The use of the forming devices makes it possible to practice individual treatment and decrease the levels of irradiation doses for intact organs and tissues.

446

Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation

A hallmark of several human cancers is loss of heterozygosity (LOH) of chromosome 17p13. The same chromosomal region is also frequently hypermethylated in cancer. Although loss of 17p13 has been often...Full Text Available

447

Randomized controlled trials of the efficacy of lung cancer screening by sputum cytology revisited: a combined mortality analysis from the Johns Hopkins Lung Project and the Memorial Sloan-Kettering Lung Study

BackgroundAdipokines, e.g. TNFα, IL-6 and leptin increase insulin resistance, and consequent hyperinsulinaemia influences breast cancer progression. Beside its mitogenic...Full Text Available

448

Questionnaire based survey of general population to assess their views about disclosure of cancer diagnosis and review of literature

BackgroundTwo randomized controlled trials of lung cancer screening initiated in the 1970's, the Johns Hopkins Lung Project and the Memorial Sloan-Kettering Lung...Full Text Available

2009-11-01

449

Proteasome Inhibition in Human Breast Cancer Cells with High Catechol-O-methyltransferase Activity by Green tea polyphenol EGCG analogs

Objective: To ascertain people's views regarding disclosure of cancer diagnosis and whether they would like to share this information with their family. The study also looked at whether if their parents were diagnosed to be suffering from cancer, would they like this information to be communicated to them. Results: The total number of persons surveyed were 520. Fifteen persons refused to participate in the survey, hence they were excluded and 505 respondents 299 male and 206 female were analyzed. Ages of the respondents were between 18 to 80 years. The study population belonged to different socio-economic groups in the society. Three hundred ninety-one (77.4%) responded positively that they would like to know if they ever suffer from cancer, while 112 (22.1%) said No and 2 (0.39%) said it doesn't matter. Three hundred seventeen (62.7%) wanted their family to be informed while 187 (37.%) said No and the attitude of 1 (0.19%) ...

2003-01-01

450

Preferential antitumor effect of the Src inhibitor dasatinib associated with a decreased proportion of aldehyde dehydrogenase 1-positive cells in breast cancer cells of the basal B subtype

A pro-drug 8 of a synthetic analog 7 is more active in its anti-proliferative activity against human breast cancer MDA-MB-231 cells possessing high Catechol-O-methyltransferase...Full Text Available

2010-02-01

451

Methods and results of a representative analysis of the radiation exposure of the population by diagnostic radiology

BackgroundRecent studies have suggested that the Src inhibitor dasatinib preferentially inhibits the growth of breast cancer cells of the basal-like subtype. To clarify this finding...Full Text Available

452

Metastatic Small Bowel Tumor from Descending Colon Cancer with Extensive Hematogenous or Lymphogenous Spread: Survey of the Japanese Literature

From the frequency of diagnostic radiologic examinations and their radiation dose delivered to the population the risk of cancer induction and genetic damage is calculated on the basis of the risk factors given by the ICRP. Thus 0.38 % and 3 % of the total mortality for cancer and leukemia, resp., can be attributed to X-ray diagnostics. Chest examinations alone result in 0.07-0.7 damages per 100,000 persons depending on the imaging technique applied. (author).

1984-01-01

453

Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy

We present the case of a 68-year-old female patient who was diagnosed with cancer of the descending colon in July 1994 and underwent partial resection of the colon (type 2, moderately to well differentiated...Full Text Available

454

Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene

IntroductionThe phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to...Full Text Available

2008-01-01

455

Dissection of the sentry ganglion by laparoscopic boarding in patients with cervix uterine cancer clinical stages IA2 at IIB

AIM: To evaluate the biological and clinical characteristics of miR-622 in gastric cancer.METHODS: We analyzed the expression of miR-622 in 57 pair matched gastric neoplastic and adjacent non-neoplastic...Full Text Available

2011-04-14

456

Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

The obtained results in presently study demonstrate that the feasibility of the detection of the sentry ganglion in cervix uterine cancer using a boarding by laparoscopic via, being necessary the use of twice labelled as much with patent blue and radioisotope (colloid of labelled rhenium with "9"9"mTc, total dose of 3 MCi) to achieve the identification of the ganglion. (Author)

2005-05-04

457

Cloning and characterization of a 77-kDa oestrogen receptor isolated from a human breast cancer cell line.

BackgroundHuman papillomavirus (HPV) infection is a major risk factor for the development of nearly all cases of cervical cancer worldwide. The presence of HPV DNA in cases of esophageal...Full Text Available

458

Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis

We have cloned and characterized a 77-kDa oestrogen receptor (ER) from an oestrogen-independent subclone of the MCF-7 human breast cancer cell line. This receptor contains an in-frame, tandem duplication...Full Text Available

1997-01-01

459

Accurate positioning for head and neck cancer patients using 2D and 3D image guidance

Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. Since the variant is located outside of a protein-coding...Full Text Available

2010-11-01

460

A Small-Molecule p53 Activator Induces Apoptosis through Inhibiting MDMX Expression in Breast Cancer Cells12

Our goal is to determine an optimized image-guided setup by comparing setup errors determined by two-dimensional (2D) and three-dimensional (3D) image guidance for head and neck cancer (HNC)...Full Text Available

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461

A Pilot Study of Lay Health Worker Outreach and Colorectal Cancer Screening Among Chinese Americans

The tumor suppressor p53 is often inactivated in breast cancer cells because the overexpression of its repressors (e.g., MDM2 and MDMX). Restoration of p53 activity by small molecules through counteracting...Full Text Available

2011-07-01

462

Synopsis of some preliminary computational studies related to unsaturated zone transport at Area G

The research team recruited eight Chinese American (seven females, one male) lay health workers (LHWs). They received 12 h of training about colorectal cancer (CRC), its screening, and basic...Full Text Available

2010-09-01

463

Surface and subsurface analysis of Sheep Mountain anticline, Wyoming

Computational transport models are described with applications in three problem areas related to unsaturated zone moisture movement beneath Area G. These studies may be used to support the ongoing maintenance of the site Performance Assessment. The three areas include: a 1-D transient analysis with average tuff hydraulic properties in the near surface region with computed results compared to field data; the influence on near surface transient moisture percolation due to realistic distributions in hydraulic properties derived statistically from the observed variance in the field data; and the west to east moisture flow in a 2-D steady geometry approximation of the Pajarito Plateau. Results indicate that a simple transient model for transport of moisture volume fraction fits field data well compared to a moisture pulse observed in the active disposal unit, pit 37. Using realistic infiltration boundary conditions for summer showers and for spring snow melt conditions, ...

1998-03-01

464

High resolution sequence stratigraphy of Scythian-early Anisian continental deposits of east of Paris basin: Applications to gas storage

The Sheep Mountain area, in the southwest Wind River Basin, is the up plunge closure of the Derby Dome-Winkleman Dome producing trend of an echelon folds which comprise the first line of folding down the northeast flank of the Wind River Mountains. The structural style exposed in the Palozoic reservoir rocks of Sheep Mountain may serve as a model for the other structural features in the Wind River Basin. As in the case of the Derby Dome and Winkleman Dome, Sheep Mountain is typically asymmetric to the southwest. Local east-directed thrusts exposed in the core of the anticline place Pennsylvania over Permian age rocks. A major change in the trend of the anticlinal crest within Sheep Mountain, suggests development of separate left-stepping en echelon closures at depth. The northwest end of Sheep Mountain also forms a left-stepping en echelon pattern with Derby Dome. The northwest plunge of Sheep Mountain is facilitated by compartmentalization across an ...

1988-01-01

465

Xeroradiography and computed radiography comparative study on diagnosis for breast cancer

Continental facies of Scythian-early Anisian age (Buntsandstein) of East of the Paris Basin form the underground gas storage reservoir exploited by Gaz de France in the area of Nancy (east of France). An accurate sedimentological study and the application of Genetic Stratigraphy principles lead to the understanding of the deposition of fluvial, which form the reservoirs, and to the reconstruction of their geometries. The subsurface data are calibrated on outcrops. Three types of fluvial systems (braided, sinuous to straight and anastomosed) are defined. A special focus on anastomosed channels permits to differentiate a proximal and a distal facies. Study of laterally continuous outcrops induces recurrent cycles of thickness, velocity and time variations (few tens to hundred ka). These correspond to the highest frequence stratigraphic units, i.e. parasequences or genetic units. Maximum of channel and levee presentation occurs during base-level ...

1995-08-01

466

Xeroradiography and computed radiography comparative study on diagnosis for breast cancer

Xeroradiography (XR) was retrospectively compared with a newly developed computed radiography (FCR) for diagnostic availability for breast cancer. FCR provides with the image processed by a computer. Subjects were 65 breast cancer patients for XR and 51 for FCR. Both methods were performed preoperatively. No significant difference was observed in distribution of age between the two groups but the average tumor size in XR group was larger than that in FCR group. Tumor shadow appeared in 44 of 65 xeromammograms (67.7%) and in 34 of 51 computed radiograms (66.7%). Microcalcification was detected in 27 of 65 xeromammograms (41.5%) and in 21 of 51 computed radiograms (41.2%). Consequently, diagnosis of breast cancer could be achieved in 47 of 65 patients (72.3%, established: 39, suspective: 8) through XR and in 41 of 51 (80.4%, established: 33, suspected: 8) through FCR. Thus FCR is thought to be more useful for breast ...

1990-04-01

467

Electromagnetic fields and cancer: how ICNIRP has dealt with the issue

Xeroradiography (XR) was retrospectively compared with a newly developed computed radiography (FCR) for diagnostic availability for breast cancer. FCR provides with the image processed by a computer. Subjects were 65 breast cancer patients for XR and 51 for FCR. Both methods were performed preoperatively. No significant difference was observed in distribution of age between the two groups but the average tumor size in XR group was larger than that in FCR group. Tumor shadow appeared in 44 of 65 xeromammograms (67.7%) and in 34 of 51 computed radiograms (66.7%). Microcalcification was detected in 27 of 65 xeromammograms (41.5%) and in 21 of 51 computed radiograms (41.2%). Consequently, diagnosis of breast cancer could be achieved in 47 of 65 patients (72.3%, established: 39, suspective: 8) through XR and in 41 of 51 (80.4%, established: 33, suspected: 8) through FCR. Thus FCR is thought to be more useful for breast ...

1990-01-01

468

Automated segmentation and quantitative characterization of radiodense tissue in digitized mammograms

Whether exposure to electromagnetic fields (EMFs) cause cancer has been vigorously debated for many years and has been the most vexing issue with which ICNIRP has had to deal during its short existence. There have been three parts of the electromagnetic spectrum that the issue of cancer has raised: static (0 Hz) magnetic fields, extremely low frequency (ELF) fields (defined as > 0-300 Hz, but concerns have been raised almost exclusively at the power frequencies of 50/60 Hz), and radiofrequency (RF) fields (300 Hz -300 GHz). By far the major problems have arisen during the construction of new high voltage transmission lines and mobile telephone systems. Actions by protest groups concerned with possible health effects, especially with cancer in children, has now reached such a scale that it is costing electrical utilities and communications companies billions of dollars annually world-wide. With such high stakes, ICNIRP ...

1996-04-01

469

Aging, tumor suppression and cancer: High-wire act!

Mammography has emerged as a reliable non-invasive technique for the early detection of breast cancer--the second leading cause of cancer-related mortality among American women. The radiographic appearance of the female breast consists of radiolucent (dark) regions due to fat and radiodense (light) regions due to connective and epithelial tissue. The amount of radiodense tissue can be used as a marker for predicting breast cancer risk. This paper presents the development of an algorithm for estimating the percentage of radiodense tissue in a digitized mammogram. The technique involves determining a dynamic threshold for segmenting radiodense indications in mammograms. Both the mammographic image and the threshold are modeled as Gaussian random variables. This work is intended to support a concurrent study at the Fox Chase Cancer Center (FCCC) exploring the association between dietary patterns and breast ...

2002-05-25

470

A cultural research approach to instrument development: the case of breast and cervical cancer screening among Latino and Anglo women.

Evolutionary theory holds that aging is a consequence of the declining force of natural selection with age. We discuss here the evidence that among the causes of aging in complex multicellular organisms, such as mammals, is the antagonistically pleiotropic effects of the cellular responses that protect the organism from cancer. Cancer is relatively rare in young mammals, owing in large measure to the activity of tumor suppressor mechanisms. These mechanisms either protect the genome from damage and/or mutations, or they elicit cellular responses--apoptosis or senescence--that eliminate or prevent the proliferation of somatic cells at risk for neoplastic transformation.We focus here on the senescence response, reviewing its causes, regulation and effects. In addition, we describe recent data that support the idea that both senescence and apoptosis may indeed be the double-edged swords predicted by the evolutionary hypothesis of antagonistic ...

2004-08-15

471

Olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin D and SDF-1.

To illustrate the implementation of a bottom-up approach to the study of culture in health disparities, this article describes the development of a cultural cancer screening scale (CCSS) using mixed methodologies. The aim was to identify cultural factors relevant to breast and cervical cancer screening, develop an instrument to assess them and examine its preliminary psychometric properties among Latin American (Latino) and non-Latino White (Anglo) women in Southern California. Seventy-eight Latino and Anglo women participated in semi-structured interviews, which were content coded based on Triandis' methods for the analysis of subjective culture. Based on the emerging cultural elements, items relevant to cancer screening were developed and pilot tested with 161 participants. After the instrument was refined, 314 Latino and Anglo women from various socioeconomic backgrounds completed the CCSS and data were factor analyzed ...

2010-09-23

472

Gene rearrangement and radiation carcinogenesis

The human olfactomedin 4 gene (OLFM4) encodes an olfactomedin-related glycoprotein. OLFM4 is normally expressed in a limited number of tissues, including the prostate, but its biological functions in prostate are largely unknown. In this study, we found that OLFM4 messenger RNA was reduced or undetectable in prostate cancer tissues and prostate cancer cell lines. To study the effects of OLFM4 on prostate cancer progression, we transfected PC-3 prostate cancer cells with OLFM4 to establish OLFM4-expressing PC-3 cell clones. The OLFM4-expressing PC-3 cell clones were found to have decreased proliferation and invasiveness compared with vector-transfected control PC-3 cells in vitro. In addition, nude mice injected with OLFM4-expressing PC-3 cells demonstrated reduced tumor growth and bone invasion and metastasis compared with mice injected with vector-transfected control cells. Mechanistic studies revealed ...

2011-04-05

473

Comparison of Stereotactic Radiosurgery and Whole Brain Radiotherapy in Patients with Four or More Brain Metastases

The development of leukemia and thyroid cancer is characterized by activation of the abl oncogene and ret oncogene, respectively. In order to clarify the relationship between these gene aberrations and radiation, the pro-myelogenous leukemia-derived cell line HL60 and the thyroid cancer-derived cell line 8505C, were irradiated in vitro with 100Gy of X-rays. RNA was then extracted from 10"8 cells of the respective cell lines and examined by the reverse transcription PCR method for rearrangements of abl and ret genes. Five kinds of positive bands were observed in the HL-60 cells irradiated with 100Gy of X-ray. Similarly, six positive bands were also observed in the 8505C cells irradiated with 100Gy. In vitro X-irradiation activation of oncogenes found in radiation induced cancers imply that gene rearrangement by X-rays is involved in the development of malignant tumors. Furthermore, in an experiment to detect radiation ...

1993-11-01

474

Clinical utility of serum ferritin levels in patients with malignant tumors treated by radiotherapy

This study was a retrospective evaluation of the efficacy of stereotactic radiosurgery (SRS) in patients with >4 metastases to the brain. Materials and Methods: Between January 2004 and December 2006, 68 patients with ?4 multiple brain metastases were included and reviewed retrospectively. Twenty-nine patients received SRS and 39 patients received whole brain radiotherapy (WBRT). Patients with small cell lung cancers and melanomas were excluded. The primary lesions were non-small cell lung cancer (69.0%) and breast cancer (13.8%) in the SRS group and non-small cell lung cancer (64.1%), breast cancer (15.4%), colorectal cancer (12.8%), esophageal cancer (5.1%) in the WBRT group. SRS involved gamma-knife radiosurgery and delivered 10?20 Gy (median, 16 Gy) in a single fraction with a 50% marginal dose. WBRT was delivered daily in 3 Gy ...

2009-09-01

475

Advanced Instrumentation and Control Methods for Small and Medium Reactors with IRIS Demonstration. Final Report. Volume 1

The serum levels of ferritin in 394 patients, including 339 patients with various malignant tumors and 23 with various non-malignant diseases, and 32 healthy subjects were determined. The normal levels of ferritin were 82.7 +- 42.3 ng/ml for males and 42.0 +- 36.9 ng/ml for females. The positive ratio of serum ferritin level was 28% in patients with malignant tumors and 22% in patients with non-malignant diseases. The usefulness of serum ferritin assay in screening for malignant tumors appeared to be limited. High serum levels of ferritin were found in patients with malignant lymphoma (positive ratio: 42%), pulmonary cancer (38%) and esophageal cancer (37%). According to the histological types, epidermoid cancer appeared to produce a higher serum level of ferritin than adenocarcinoma in patients with pulmonary cancer. It was interesting that malignant lymphoma had a high serum level of ferritin in spite ...

1983-10-01

476

A decade of petroleum developments

Development and deployment of small-scale nuclear power reactors and their maintenance, monitoring, and control are part of the mission under the Small Modular Reactor (SMR) program. The objectives of this NERI-consortium research project are to investigate, develop, and validate advanced methods for sensing, controlling, monitoring, diagnosis, and prognosis of these reactors, and to demonstrate the methods with application to one of the proposed integral pressurized water reactors (IPWR). For this project, the IPWR design by Westinghouse, the International Reactor Secure and Innovative (IRIS), has been used to demonstrate the techniques developed under this project. The research focuses on three topical areas with the following objectives. Objective 1 - Develop and apply simulation capabilities and sensitivity/uncertainty analysis methods to address sensor deployment analysis and small grid stability issues. Objective 2 - Develop and test an autonomous and ...

2009-02-23

477

The immunological era in melanoma treatment: new challenges for heat shock protein-based vaccine in the advanced disease

Canada's offshore Atlantic petroleum industry is celebrating its tenth anniversary in 2001. This article chronicles the development of the industry discussing the many challenges and setbacks and the eventual triumphs that accompanied the industry's development over the years. Highlights discussed include shipping first oil from the Cohasset Field in July 1992; the financial crisis caused by the withdrawal of Gulf Oil from the Hibernia consortium in the same year; new funding and the beginning of the gravity-based structure construction at Bulls Arm in 1993; striking oil in the Hibernia Field in 1994; the start of exploration and development of the Terra Nova field by Petro-Canada in the same year, based on the floating production, storage and offloading (FPSO) system, which heralded a new era of offshore development in eastern Canada. Approval by the Nova Scotia government of the third and final phase of the Sable Offshore Energy Project followed ...

2001-03-01

478

British Library Electronic Table of Contents (United Kingdom)

Introduction: Tumor-derived heat shock protein (HSP)-peptide complexes (HSPPCs) induced immunity against malignancies in preclinical trials, working across tumor types and bypassing the need to identify single immunogenic peptides. These results paved the way for the use of human gp96 obtained from autologous tumor samples as an anti-cancer vaccine. Areas covered: Autologous tumor-derived HSP gp96 peptide complex (HSPPC-96) vaccine is emerging as a tumor- and patient-specific cancer vaccine, with confirmed activity in several malignancies. It has been tested in Phase III clinical trials in advanced melanoma and kidney cancer with evidence for efficacy in patients with earlier stage disease. HSPPC-96-based vaccine demonstrated an excellent safety profile, thus emerging as a novel therapeuti...

2011-01-01

479

The Significance of PITX2 Overexpression in Human Colorectal Cancer

British Library Electronic Table of Contents (United Kingdom)

Purpose The paired-like homeodomain transcription factor 2 (PITX2) gene encodes a transcription factor controlled by the WNT/Dvl/CTNNB1 and Hedgehog/TGFB pathways in the pathogenesis of colorectal cancer (CRC). Although PITX2 is reportedly involved in various functions, including tissue development by controlling cell growth, its significance in CRC remains unclear. We report our findings regarding abnormal PITX2 expression in human CRC. Methods PITX2 expression was evaluated in 5 human CRC cell lines and 92 primary CRC samples. Cell growth was evaluated after inhibition of PITX2 expression or after exogenous introduction of PITX2. Results PITX2 expression was seen in all the five CRC cell lines. The study of tissue samples indicated that PITX2 expression was significantly higher in cancer...

2011-01-01

480

The Negative Effect of Triple-Negative Breast Cancer on Outcome after Breast-Conserving Therapy

British Library Electronic Table of Contents (United Kingdom)

Purpose To evaluate disease failure patterns and overall survival (OS) of women with triple-negative (TN) breast cancer who underwent breast-conserving therapy (BCT) and to understand the relationship of TN tumors with other prognostic factors. Patients and Methods The Surveillance, Epidemiology, and End Results (SEER) registry identified 562 women diagnosed and/or treated with unilateral invasive breast cancer during 2003?2004 at three Emory hospitals. After medical record review, 193 eligible women, with all tumor types, received BCT. Primary endpoints (local, regional, and distant recurrences) and secondary endpoint (OS) were evaluated using chi-square tests and Cox proportional hazards models. Results Of the 193 women, 33 (17.1%) had TN tumors and 160 (82.9%) had non-TN tumors. Patient...

2011-01-01

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481

The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein

British Library Electronic Table of Contents (United Kingdom)

DFNA5 was first identified as a gene causing autosomal dominant hearing loss (HL). Different mutations have been found, all exerting a highly specific gain-of-function effect, in which skipping of exon 8 causes the HL. Later reports revealed the involvement of the gene in different types of cancer. Epigenetic silencing of DFNA5 in a large percentage of gastric, colorectal and breast tumors and p53-dependent transcriptional activity have been reported, concluding that DFNA5 acts as a tumor suppressor gene in different frequent types of cancer. Despite these data, the molecular function of DFNA5 has not been investigated properly. Previous transfection studies with mutant DFNA5 in yeast and in mammalian cells showed a toxic effect of the mutant protein, which was not seen after transfection ...

2011-01-01

482

British Library Electronic Table of Contents (United Kingdom)

PurposeTo conduct a retrospective analysis within a large university teaching hospital, comparing outcomes between patients receiving either radical surgery or radiotherapy as curative treatment for bladder cancer.Patients and MethodsBetween March 1996 and December 2000, 169 patients were treated radically for muscle-invasive bladder cancer. Data were collected from patient notes. Statistical analyses were performed using Kaplan-Meier methods and Cox proportional hazards regression analysis to compare radiotherapy and surgical outcome data.ResultsThere was no difference in overall, cause-specific, and distant recurrence-free survival at 5 years between the two groups, despite the radiotherapy group being older (median age, 75.3 years vs. 68.2 years). There were 31 local bladder recurrences...

2008-01-01

483

Self-valued health in Danish women after cervix cancer surgery-A retrospective questionnaire study

British Library Electronic Table of Contents (United Kingdom)

Women treated of localised stages of cervix cancer have a very good prognosis. But do health care professionals have a tendency to underestimate the potential need for rehabilitation of this group? To be able to answer this question this study aimed to develop knowledge concerning these women's own perception of their health during a long period after surgical cancer treatment. A total of 398 women who underwent radical hysterectomy in the period from the 1 January 1983 to 31 December 2000 participated in the study at Aarhus University Hospital, Skejby in Denmark 2001-2003. All patients initially filled in an internally validated questionnaire. Subsequently a sample of 100 women filled in the questionnaires Short Form -36 and Sense of Coherence to evaluate their self-reported health. Analy...

2007-01-01

484

Risk estimates of liver cancer due to aflatoxin exposure from peanuts and peanut products

Resveratrol Potentiates the Cytotoxic Oxidative Stress Induced by Chemotherapy in Human Colon Cancer Cells

An assessment was undertaken of the risk of liver cancer in the USA associated with aflatoxin ingestion from peanuts. Both laboratory-animal data and epidemiological data collected from the scientific literature and several prominent mathematical extrapolation techniques were used. Risk estimates differed by a factor of greater than 1000 when the extrapolated results of three selected animal studies were analysed. Dose-response data for the male Fischer rat, the most sensitive mammalian species studied, produced an estimate of 158 cases of liver cancer per year in the USA at current levels of aflatoxin exposure. An estimate of 58 annual cases was predicted on the basis of epidemiological data of populations in Africa and Thailand.

1984-06-01

485

British Library Electronic Table of Contents (United Kingdom)

Abstract The treatment of advanced colorectal cancer with 5-fluorouracil has two major problems: development of tumor resistance and toxicity toward normal tissues. The aim of this study was to investigate the possible advantages of combining 5-fluorouracil (5-FU) with resveratrol (trans-3, 4prime, 5-trihydroxystilbene) for treating HT-29 and SW-620 colorectal carcinoma cell lines. Since combined treatment using 5-FU with resveratrol resulted in a significant decrease in long-term cell survival, we investigated the possible basis of this synergistic interaction at a molecular level, focusing on oxidative stress as a possible mediator of cell death. Resveratrol established interactions with the mitochondria of cancer cells and induced an imbalance in cellular antioxidant activities, leading...

2011-01-01

486

Proteomic analysis of apoptosis induction in human lung cancer cells by recombinant MVL

British Library Electronic Table of Contents (United Kingdom)

Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic changes in A549 cells, and to identify the molecular pathways responsible for the anti-cancer action of R-MVL. We found that R-MVL induces A549 cells apoptosis in a dose-dependent manner by using MTT assay, fluorescent microscope (FM) and flow cytometry (FCM), and the IC50 was calculated to be 24.12??g/ml. Subsequently, 7 altered proteins in R-MVL-treated A549 cells were identified, including upregulated aldehyde dehydrogenase 1 and ?-actin, and five downregulated proteins: heat s...

2011-01-01

487

Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients

British Library Electronic Table of Contents (United Kingdom)

High-level expression of mitotic arrest defective protein 2 (MAD2), a central component of the spindle assembly checkpoint, has been observed in a variety of human malignancies. Aim of the present study was to observe the expression of MAD2 in human non-small-cell lung cancer (NSCLC) and explore its clinicopathologic significance and evaluate MAD2 expression as a prognostic marker. MAD2 transcript was found to be overexpressed in the great majority of lung cancers by semi-quantitative RT-PCR. A total of 358 NSCLCs were analyzed immunohistochemically on tissue microarrays. High-level MAD2 expression was observed in 26.3% (94 of 358 cases), and correlated with male sex (P=0.0002), tumor progression (pT status) (P=0.0009), visceral or parietal pleural invasion (P=0.0151), non-adenocarcinoma, ...

2011-01-01

488

New procedures. Comprehensive staging of lung cancer by MRI

Monitoring noise-resonant effects in cancer growth influenced by spontaneous fluctuations and periodic treatment

Lung cancer staging according to the TNM system is based on morphological assessment of the primary cancer, lymph nodes and metastases. All aspects of this important oncological classification are measurable with MRI. Pulmonary nodules can be detected at the clinically relevant size of 4-5 mm in diameter. The extent of mediastinal, hilar and supraclavicular lymph node affection can be assessed at the same time. The predominant metastatic spread to the adrenal glands and spine can be detected in coronal orientation during dedicated MRI of the lungs. Search focused whole body MRI completes the staging. Various additional MR imaging techniques provide further functional and clinically relevant information during a single examination. In the oncological context the most important techniques are imaging of perfusion and tumor motion. Functional MRI of the lungs complements the pure staging and improves surgical approaches and radiotherapy planning. ...

2010-08-01

489

CERN Document Server

In the paper we investigate a mathematical model describing the growth of tumor in the presence of immune response of a host organism. The dynamics of tumour and immune cells is based on the generic Michaelis-Menten kinetics describing interaction and competition between the tumour and the immune system. The appropriate phenomenological equation modeling cell-mediated immune surveillance against cancer is of the predator-prey form and within a given choice of parameters exhibits bistability. Under the influence of spontaneous weak fluctuations, the model may be analyzed in terms of a stochastic differential equation bearing the form of an overdamped Langevin-like dynamics in the external quasi-potential represented by a double well. We analyze properties of the system within the range of parameters for which the potential wells are of the same depth and when the additional perturbation describing a periodic treatment is insufficient to overcome the barrier height ...

2007-01-01

490

Interinstitutional Variations in Planning for Stereotactic Body Radiation Therapy for Lung Cancer

British Library Electronic Table of Contents (United Kingdom)

Purpose: The aim of this study was to assess interinstitutional variations in planning for stereotactic body radiation therapy (SBRT) for lung cancer before the start of the Japan Clinical Oncology Group (JCOG) 0403 trial.Methods and Materials: Eleven institutions created virtual plans for four cases of solitary lung cancer. The created plans should satisfy the target definitions and the dose constraints for the JCOG 0403 protocol.Results: FOCUS/XiO (CMS) was used in six institutions, Eclipse (Varian) in 3, Cadplan (Varian) in one, and Pinnacle3 (Philips/ADAC) in one. Dose calculation algorithms of Clarkson with effective path length correction and superposition were used in FOCUS/XiO; pencil beam convolution with Batho power law correction was used in Eclipse and Cadplan; and collapsed co...

2007-01-01

491

Incidence and management of secondary malignancies in patients with retinoblastoma and Ewing's sarcoma

Health risks arising from ionizing radiation and chemical pollutants

Childhood cancer survivors at highest risk of developing a secondary malignancy are those with hereditary retinoblastoma. The majority of such secondary cancers will be sarcomas, most commonly of bone. One-third of these occur outside a typical radiation field, commonly in an extremity. Bone sarcoma is also the most commonly reported secondary cancer to develop among survivors of Ewing's sarcoma. In this group, radiation doses greater than 60 Gy as well as alkylating agent chemotherapy have been identified as contributors to the increased risk. The prognosis for patients with a secondary sarcoma has been poor, with few cures reported to date. However, an aggressive, combined modality approach, including radical resection, postoperative radiation, and adjuvant chemotherapy, may improve the survival rate.

492

Estimating personal costs incurred by a woman participating in mammography screening in the National Breast and Cervical Cancer Early Detection Program

In quantifying health risks arising from radiation exposure and synergistic effects promoted by radiation the dose-effect relationship must be used as a basis. Special problems arise in the extrapolation of experimental results or in the treatment of data in the region of low doses administered over long periods of time. For radiation protection purposes, especially manifestations of cancer and genetic effects are significant. The International Commission on Radiation Protection has published binding guiding values on the basis of which to assess the risk of cancer. The cancer risk and genetic risks are estimated for relevant dose ranges and compared with other factors of civilization. For the most important chemical pollutants emitted into the environment the possibilities of impacts arising from synergistic effects are discussed on the basis of the rules and regulations specified in German antipollution legislation. ...

1979-10-03

493

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND.The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) covers the direct clinical costs of breast and cervical cancer screening and diagnostic follow-up for medically underserved, low-income women. Personal costs are not covered. In this report, the authors estimated personal costs per woman participating in NBCCEDP mammography screening by race/ethnicity and also estimated lifetime personal costs (ages 50-74 years).METHODS.A decision analysis model was constructed and parameterized by using empiric data from a retrospective cohort survey of mammography rescreening among women ages 50 years to 64 years who participated in the NBCCEDP. Data from 1870 women were collected from 1999 to 2000. The model simulated the flow of resources incurred by a woman participat...

2008-01-01

494

Cytogenetic polyclonality of breast carcinomas: Association with Clinico-Pathological Characteristics and Outcome

British Library Electronic Table of Contents (United Kingdom)

Abstract Routinely used prognostic factors fail to predict clinical outcome in a significant proportion of breast cancer patients, implying that they can not detect some important biological characteristics. Chromosomal changes have been described in breast carcinomas for many years but their significance is not clear. We compared chromosomal changes with clinico-pathological characteristics and clinical outcome in 203 breast cancer patients with a follow-up of 9-18 years. Combining data from classical cytogenetics and flow cytometry revealed chromosomal abnormalities in 142 cases (70%). Of these, 51 (35.9%) contained two or more cytogenetically abnormal clones. Polyclonality was significantly associated with poor breast-cancer-specific survival (P = 0.03) within 5 years, independent of tu...

2011-01-01

495

Computed tomography colonography: the future of colon cancer screening

Computed tomography colonography: the future of colon cancer screening

Colorectal cancer (CRC) is the most common cause of cancer death among Canadian non-smokers. Each year about 21,500 Canadians are diagnosed with CRC. Ninety percent of cases occur in people aged 50 years or older. An estimated 4,800 Canadian men and 4,100 Canadian women die each year from the disease. About 75% of all new CRC cases arise in people with no known risk factors. Computed tomography colonography (CTC), a cross-sectional imaging examination that permits complete structural examination of the colon, shows promise as a tool for CRC screening. This article reviews the rationale for CRC screening, currently recommended Canadian and American screening guidelines and screening tools, and current evidence supporting CTC as a CRC screening tool and its advantages over conventional screening methods. (author)

2008-10-15

496

Comparing the Safety and Efficiency of Conventional Monopolar, Plasmakinetic, and Holmium Laser Transurethral Resection of Primary Non-muscle Invasive Bladder Cancer

Colorectal cancer (CRC) is the most common cause of cancer death among Canadian non-smokers. Each year about 21,500 Canadians are diagnosed with CRC. Ninety percent of cases occur in people aged 50 years or older. An estimated 4,800 Canadian men and 4,100 Canadian women die each year from the disease. About 75% of all new CRC cases arise in people with no known risk factors. Computed tomography colonography (CTC), a cross-sectional imaging examination that permits complete structural examination of the colon, shows promise as a tool for CRC screening. This article reviews the rationale for CRC screening, currently recommended Canadian and American screening guidelines and screening tools, and current evidence supporting CTC as a CRC screening tool and its advantages over conventional screening methods. (author)

2008-10-01

497

British Library Electronic Table of Contents (United Kingdom)

Abstract Purpose: To compare the safety and efficiency of conventional monopolar, plasmakinetic and holmium laser transurethral resection of bladder tumor (CM-TURBT, PK-TURBT and HoL-TURBT) while managing primary non-muscle invasive bladder cancer. Patients and Methods: From 2005 to 2009, 173 patients with primary non-muscle invasive bladder cancer underwent endoscopic surgery. Among them, 51 patients underwent CM-TURBT, 58 patients underwent PK-TURBT, and 64 patients underwent HoL-TURBT. All patients were divided into three risk groups (low, intermediate, and high) based on the European Association of Urology guidelines and prognostic factors of recurrence. Clinical data, included preoperative, operative, and postoperative management and follow-up, were recorded. Results: Patient demograp...

2010-01-01

498

Cancers | Special Issue: Advances and Research Progress in Hepatocellular Carcinoma

An application of artificial neural networks in breast cancer recognition using scintimammography

...comAbstract: Hepatocellular carcinoma (HCC), once thought to be a rare tumor in North America, is a rapidly increasing type of cancer in recent years in the United States. Current treatment modalities to halt the disease progression are only marginally effective. The mainstay treatment ...In addition, NM was shown to down-regulate urokinase plasminogen activator (by fibrin zymography) and up-regulate tissue inhibitors of metalloproteinases (by reverse zymography) in another HCC cell line, Sk-Hep-1. MMP-2 and MMP-9 activities were further modulated by cytokines, inducers and inhibitors, including NM. In ... Our results suggest that NM is an excellent candidate for therapeutic use in the treatment HCC by inhibiting critical parameters in cancer development and progression, such as proliferation, invasion and metastasis, and by inducing apoptosis. Last update: 2 September 2011 JavaScript seems ...

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