WorldWideScience
1

Evaluation of Oral Administration of Adenine to Dogs and Primates.  

Science.gov (United States)

Little change was observed in primates fed 75 mg/kg adenine over the four-week period. Minimal tissue pathology was encountered upon completion of the study. In contrast to earlier studies in which oral feeding of adenine to dogs caused severe symptoms, a...

1974-01-01

2

Socio-demographic disparity in oral health among the poor: a cross sectional study of early adolescents in Kilwa district, Tanzania  

UK PubMed Central (United Kingdom)

BackgroundThere is a lack of studies considering social disparity in oral health emanating from adolescents in low-income countries. This study aimed to assess socio-demographic...Full Text Available

3

Effect of oral contraceptives on blood pressure and on plasma renin, renin substrate, and corticosteroids  

UK PubMed Central (United Kingdom)

A rise in blood pressure associated with oral contraceptives is well established but the frequency with which it develops is not known. Early results from a controlled long-term prospective study have...Full Text Available

1969-01-01

4

Infant Milk Feeding Influences Adult Bone Health: A Prospective Study from Birth to 32 Years  

UK PubMed Central (United Kingdom)

BackgroundPeak bone mass, attained by early adulthood, is influenced by genetic and life-style factors. Early infant feeding and duration of breastfeeding in particular, associate...Full Text Available

5

Sulfamethazine residues in uncooked edible tissues of port following recommended oral administration and withdrawal.  

UK PubMed Central (United Kingdom)

Commercial feed rations containing sulfamethazine at the level of 110 ppm were fed for a period of 65 days to market pigs in a study simulating normal farm practices. The levels of sulfamethazine at...Full Text Available

1980-07-01

6

An oral nervous necrosis virus vaccine using Vibrio anguillarum as an expression host provides early protection  

British Library Electronic Table of Contents (United Kingdom)

Oral vaccination is the most desirable immunization method by which to prevent fish disease occurring at the early larval stage. We developed an Escherichia coli-based oral nervous necrosis virus (NNV) subunit vaccine and demonstrated its effectiveness in orange spotted grouper (Epinephelus coioides) fry. However, the incubation period was determined to be over 2weeks. To enhance the efficacy and shorten the incubation period, a safe and digestible biological adjuvant should be found. Vibrio anguillarum, a common marine bacterium with immune-stimulatory capability was selected as an expression host. An expression vector containing its heat shock protein 60 gene (groE) as an inducible promoter was constructed to express recombinant NNV coat protein as an antigen. The recombinant V. anguilla...

2011-01-01

7

Effect of age-at-weaning on digestive capacity of white seabream (Diplodus sargus)  

British Library Electronic Table of Contents (United Kingdom)

White seabream (Diplodus sargus) is today recognized as a potential species for Mediterranean aquaculture. Still, scarce information exists on weaning practices in order to reduce the live food period. This study aims to evaluate the effect of an early weaning on fish larvae digestive enzymes activities. In order to accomplish this, larvae were weaned with an inert diet at 20days after hatching (DAH) (feeding regime W20) and a control group was weaned at 27DAH (feeding regime W27). Before weaning, the onset and development of the main digestive enzymes were studied. The pattern of variation of digestive enzymes activities were analyzed at 0, 2, 9, 13 and 20DAH, and from then on at 0, 1 and 3weeks after diet introduction; that is, at 20, 27 and 41days for feeding regime W20, and days 27, 34...

2010-01-01

8

ENSO affects sex ratio progeny in captive Iberian red deer despite a steady feeding regime  

British Library Electronic Table of Contents (United Kingdom)

Climate variability greatly affects animals through direct and indirect effects. Animals with slow reproductive adaptation to ecological changes such as large mammals are likely to have evolved mechanisms to anticipate early such impacts of climate variability on the environment. One of the adaptive mechanisms between reproductive costs and benefits in mammals affects parental investment through biases in sex ratio. Deer might be likely to show an early detection of climate variability because conception takes place in early autumn, but the main raising cost in deer concerns lactation, which takes place at the end of the following spring. The aim of this paper is to assess whether there is a relationship between global indices of climate variability such as El Ni?o-Southern Oscillation (EN...

2011-01-01

9

Oral Health in Women During Preconception and Pregnancy: Implications for Birth Outcomes and Infant Oral Health  

UK PubMed Central (United Kingdom)

The mouth is an obvious portal of entry to the body, and oral health reflects and influences general health and well being. Maternal oral health has significant implications for birth outcomes and infant...Full Text Available

2006-09-01

11

Lesion of the esophagus by tetracycline medication  

Energy Technology Data Exchange (ETDEWEB)

One case of esophagitis caused by oral medication of Tetracycline is reported. The cause and factors predisposing to this uncommon complication of oral medication are discussed.

1984-06-01

12

Pyridoxine dependent epilepsy and antiquitin deficiency Clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.  

Science.gov (United States)

Antiquitin (ATQ) deficiency is the main cause of pyridoxine dependent epilepsy characterized by early onset epileptic encephalopathy responsive to large dosages of pyridoxine. Despite seizure control most patients have intellectual disability. Folinic acid responsive seizures (FARS) are genetically identical to ATQ deficiency. ATQ functions as an aldehyde dehydrogenase (ALDH7A1) in the lysine degradation pathway. Its deficiency results in accumulation of ?-aminoadipic semialdehyde (AASA), piperideine-6-carboxylate (P6C) and pipecolic acid, which serve as diagnostic markers in urine, plasma, and CSF. To interrupt seizures a dose of 100mg of pyridoxine-HCl is given intravenously, or orally/enterally with 30mg/kg/day. First administration may result in respiratory arrest in responders, and thus treatment should be performed with support of respiratory management. To make sure that late and masked response is not missed, treatment with ...

2011-05-24

13

Clinical usefulness of Thallium-201 chloride scintigraphy for evaluation of oral malignant tumors. Relationship between retention index, histological type and tumor involvement  

Energy Technology Data Exchange (ETDEWEB)

In this report we assessed retrospectively the usefulness of Thallium-201 chloride scintigraphy for diagnosing malignant tumors of the maxillofacial region. Thallium-201 chloride scintigraphy was performed on 74 patients with malignant tumors and 8 patients with benign tumors, and a retention index was calculated from the early and delayed scintigrams (delayed accumulation ratio/ early accumulation ratio). This retention index depended on the blood flow of tumors and the affinity of tumors with Thallium-201 chloride. The retention index was large for malignant tumors (avg.: 1.05) and small for benign tumors (avg.: 0.78). Concerning the degree of malignancy (the histological type and the degree of tumor involvement), the retention index was higher in highly malignant tumors (1.20 for poorly-differentiated tumors and 1.19 for aggressive-involvement-type tumors) and lower for tumors of low malignancy (1.02 for well-differentiated tumors and 0.98 ...

1999-09-01

14

An availability of brain magnetic resonance imaging (MRI) in the early diagnosis of latent hepatic encephalopathy  

Energy Technology Data Exchange (ETDEWEB)

Brain MRI was carried out in patients with chronic liver diseases. No abnormal findings were recognized in patients with chronic viral hepatitis, while 59.2% of cirrhotics showed a symmetrically strong signal in basal ganglia on T1 weighted image in MRI. This finding significantly related with lowered Fischer`s ratio of serum amino acid, increased levels of serum phenylalanine, tyrosine and hyaluronic acid, prolonged prothrombin time and decreased platelet counts in the peripheral blood. Overt hepatic encephalopathy was observed in 6 of 34 patients with the strong signal in MRI during follow-up period, while none of patients without that finding developed hepatic encephalopathy. These results have indicated that the strong signal in basal ganglia on MRI appears in cirrhotic patients with severe liver dysfunction, and it is an useful index in the early diagnosis of latent hepatic encephalopathy. An improvement of this MRI finding was not observed by long-term ...

1996-03-01

15

[Single and 4-week oral toxicity studies of prulifloxacin (NM441) in aged dogs].  

Science.gov (United States)

Single-dose and repeated dose toxicity studies of prulifloxacin, a new antibacterial agent, were conducted in aged beagle dogs. I. A single-dose toxicity study Prulifloxacin was administered orally to aged female dogs at a single dose of 2500 and 5000 mg/kg. No death occurred in any group. Vomiting was observed in one of two animals at 2500 mg/kg and in both animals at 5000 mg/kg 3-4 hr after dosing. At 5000 mg/kg, vomiting was observed in both animals after feeding on the day after dosing. One animal also showed soft stool. Thereafter, no abnormalities were observed in any animal. No test article related changes were noted in food consumption, water consumption, body weight or pathological examination in any group. The results show that the lethal dose of prulifloxacin is judged to be greater than 5000 mg/kg in aged female dogs. II. A repeated dose toxicity study Aged male and female dogs were given the test article orally ...

1996-06-01

16

Oral cancer awareness amongst hospital nursing staff: a pilot study  

UK PubMed Central (United Kingdom)

BackgroundOral cancer is as prevalent as cervical and testicular cancer in the United Kingdom. Nursing staff provide the oral health care for the patient population in hospital....Full Text Available

17

Impact of Clinical Oral Chemotherapy Program on Wastage and Hospitalizations  

UK PubMed Central (United Kingdom)

Purpose:The oral chemotherapy cycle management program (CMP) provides clinical management support to patients receiving certain oral chemotherapies. The CMP includes a dose-monitoring...Full Text Available

2011-05-01

18

Suitability of Using Duckweed as Feed and Treated Sewage as Water Source in Tilapia Aquaculture  

International Nuclear Information System (INIS)

Use of treated effluent and duckweed biomass from a pilot-scale UASB-duckweed ponds system treating domestic sewage was evaluated in rearing Nile tilapia (Oreochromis niloticus). Nutritional value of duckweed as sole feed was compared with wheat bran. Two sources of water were used for each feed trial, treated-sewage and freshwater. The experiment was conducted in parallel with a conventional settled sewage-fed fishpond. Results of growth performance demonstrated that, in case of freshwater ponds specific growth rate (SGR) of tilapia fed on fresh duckweed was significantly (p < 0.01) higher than the SGR in wheat bran fed pond. No significant difference (p > 0.05) was observed between the two feeding regimes in treated sewage fed ponds. The SGR of tilapia reared in the treated sewage-wheat bran-fed pond (TWP) was significant higher (p <0.01) than the SGR in the freshwater-wheat bran-fed pond (FWP). On the other ...

2004-12-27

19

Improvements in the cost of liquid fuels from direct coal liquefaction  

International Nuclear Information System (INIS)

This paper presents an assessment of recent improvements in the technology for direct coal liquefaction on the estimated commercial economics. The basis for the design and cost estimates is a series of studies sponsored by Amoco Corporation and Electric Power Research Institute, which were derived from the highly detailed Breckinridge Project, completed in the early 1980s under DOE sponsorship. The technology, design, and cost estimates reflect the current two-stage liquefaction technology practiced at the Advanced Coal Liquefaction Research facility in Wilsonville, Alabama. Details of the design bases and cost estimates and how they compare with the original Breckinridge study are described. Also examined are effects of feed coal rank, product slate, and the source of hydrogen (natural gas or coal) on the costs. Finally, the ways that projected future improvements in the technology will change the design and lead to lower costs are discussed. ...

20

Graphium agamemnon Linnaeus (Lepidoptera: Papilionidae), a pest of soursop (Annona muricata Linnaeus), in Vietnam: Biology and a novel method of control  

British Library Electronic Table of Contents (United Kingdom)

Abstract Few butterflies are pests of economic significance, but some may be locally destructive, such as the papilionid Graphium agamemnon Linnaeus, which is known to feed on the commercially important soursop (Annona muricata Linnaeus) in Vietnam. This paper documents the life history and ecology ofG. agamemnon and investigates commonly used control measures in south-east Vietnam. A novel method of controlling G. agamemnon infestation is described. If soursop basal rootstock (Annona glabra Linnaeus) is encouraged to shoot during times of peak butterfly activity, ovipositing G. agamemnon females are preferentially attracted to the new growth where the resulting early stages may be easily detected and removed by hand.

2008-01-01

25

Radial keratoneuritis as a presenting sign in acanthamoeba keratitis.  

Science.gov (United States)

The visual outcomes of Acanthamoeba keratitis, a rare cause of corneal infection, can be devastating. This paper reports two contact lens wearers with severe pain and photophobia who presented to the emergency room. Biomicroscopy revealed radial keratoneuritis in both individuals. Tissue culture on a nonnutrient agar plate with Escherichia coli overlay resulted in a heavy growth of Acanthamoeba. The inpatient treatment included 0.02% polyhexamethylene biguanide, chlorhexidine, neomycin/polymyxin B/bacitracin (Neosporin), and oral fluconazole, which successfully controlled the corneal infection and improvement in the best corrected visual acuity in both patients. Infection did not recur during the 12-month follow-up period. Acanthamoeba keratitis can present as radial keratoneuritis, mimicking other common corneal infections resulting in diagnostic and treatment delays. Early diagnosis and prudent treatment of Acanthamoeba keratitis are the keys ...

2011-07-01

26

Mad Cow: Why Organic Beef is Safer than Conventional Beef in theU.S.  

Wastenet

... In order to produce organic livestock feed, feed mills must be inspected and certified. If they produce both organic and non-organic feed, they must implement procedures, backed up by records, to prevent the commingling of organic and non-organic feed. This includes steps to clean storage bins and mixing and bagging equipment prior to producing batches of organic feed. Organic feed mills also must prevent ...

27

Use of Oral Bisphosphonates by Older Adults with Fractures and Impaired Renal Function  

UK PubMed Central (United Kingdom)

Background:The manufacturers of oral bisphosphonates (alendronate, risedronate) recommend avoiding use of these drugs in patients with renal impairment. However, many patients who...Full Text Available

2011-01-01

28

Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion  

UK PubMed Central (United Kingdom)

BackgroundCelecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration of celecoxib...Full Text Available

29

Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers  

UK PubMed Central (United Kingdom)

AimsTo assess the tolerability and pharmacokinetic profile of single and repeat doses of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers.Full Text Available

1998-01-01

30

Pharmacokinetics and bioavailability of intravenous-to-oral enoxacin in elderly patients with complicated urinary tract infections.  

UK PubMed Central (United Kingdom)

The pharmacokinetics of oral fluoroquinolone antibiotics in normal volunteers have been studied extensively; however, limited patient data exist. Enoxacin steady-state pharmacokinetics and bioavailability...Full Text Available

1990-10-01

31

Oral manifestations of HIV infection in children and adults receiving highly active anti-retroviral therapy [HAART] in Dar es Salaam, Tanzania  

UK PubMed Central (United Kingdom)

BackgroundThe aim of the study was to compare the prevalence and types of HIV-related oral lesions between children and adult Tanzanian patients on HAART with those not on HAART...Full Text Available

32

NASA JOHNSON SPACE CENTER ORAL HISTORY PROJECT ORAL  

Science.gov (United States)

Jan 15, 2004 ... thought I would have a difficult time working with. ...... they were absolutely right, because everybody said it rained cats and dogs on the orbit ...... We know that in the military. You can ask any military ...

33

Metabolism of iodomethane in the rat  

UK PubMed Central (United Kingdom)

1. The LD50 of iodomethane orally administered to rats is 76mg./kg. body wt. but repeated daily doses of 30–50mg./kg. body wt. are without effect. 2. Oral doses of iodomethane to...Full Text Available

1966-01-01

34

Expression of p53 in leukoplakia and squamous cell carcinoma of the oral mucosa: correlation with expression of Ki67  

UK PubMed Central (United Kingdom)

Aim—To study p53 expression in relation to proliferative status in normal and nondysplastic, dysplastic and malignant lesions of the oral mucosa.Method—The...Full Text Available

1996-06-01

35

Efficacy of standard glucose-based and reduced-osmolarity maltodextrin-based oral rehydration solutions: effect of sugar malabsorption.  

UK PubMed Central (United Kingdom)

Previously we reported that standard oral rehydration salts (ORS) solution is not as effective as a reduced-osmolarity glucose-based ORS for the treatment of children with acute noncholera diarrhoea:...Full Text Available

1996-01-01

36

Alcohol-folate interactions in women's oral cancer risk: A prospective cohort study  

UK PubMed Central (United Kingdom)

BackgroundThe aim of this cohort study was to quantify the effect of alcohol in the risk of oral cancer in different strata of folate intake, controlling for known...Full Text Available

2010-10-01

37

Detection and Diagnosis of Oral Neoplasia with an Optical ...  

Science.gov (United States)

... Thus, 0CM provides the potential to image epithelial tissue with the subcellular resolution needed to assess the pathologic state of tissue. ...

38

Structural and functional responses of benthic invertebrates to imidacloprid in outdoor stream mesocosms  

International Nuclear Information System (INIS)

Structural and functional responses of a benthic macroinvertebrate assemblage to pulses of the insecticide imidacloprid were assessed in outdoor stream mesocosms. Imidacloprid pulses reduced invertebrate abundance and community diversity in imidacloprid-dosed streams compared to control streams. These results correlated well with effects of imidacloprid on leaf litter decomposition and feeding rates of Pteronarcys comstocki, a stonefly, in artificial streams. Reductions in oxygen consumption of stoneflies exposed to imidacloprid were also observed in laboratory experiments. Our findings suggest that leaf litter degradation and single species responses can be sensitive ecotoxicological endpoints that can be used as early warning indicators and biomonitoring tools for pesticide contamination. The data generated illustrates the value of mesocosm experiments in environmental assessment and how the consideration of functional and structural ...

39

Oxidative dimerization of methane over lead-magnesium mixed oxide catalysts  

Energy Technology Data Exchange (ETDEWEB)

Our goal was a process to convert methane to higher hydrocarbons oxidatively, since this circumvents thermodynamic yield limits of a strictly degydrogenative process. Keller and Bhasin converted thermodynamic yield limits of a strictly dehydrogenative process. Keller and Bhasin converted methane to higher hydrocarbons by using metal oxides as oxidants, without co-fed oxygen. They stated that selectivity is necessarily poor if gaseous oxygen is present. Jones and Sofranko have also used reducible metal oxides as oxidants in a group of their parents, but later used some of those materials with continuous O{sub 2} feed without much loss of selectivity. Baerns, Lunsford and Otsuka have shown that high selectivity could be possible with co-fed O{sub 2} at least for low O{sub 2} partial pressures, over PbO-A1{sub 2}O{sub 3}, Li-MgO and rare earths. The performance of a group of multicomponent oxide catalysts, containing lead and magnesium oxides, for oxidative conversion ...

1987-08-01

40

What Do We Feed to Food-Production Animals? A Review of Animal Feed Ingredients and Their Potential Impacts on Human Health  

UK PubMed Central (United Kingdom)

ObjectiveAnimal feeding practices in the United States have changed considerably over the past century. As large-scale, concentrated production methods have become the predominant...Full Text Available

2007-05-01

41

The relationship between herd level disease incidence and a return over feed index in Ontario dairy herds  

UK PubMed Central (United Kingdom)

The objective of the current research was to examine the association of herd level disease incidence with the return over feed (ROF) (milk income minus feed cost) herd profit index offered through Canwest...Full Text Available

2006-08-01

42

Molecular Analyses of Salmonellaenterica Isolates from Fish Feed Factories and Fish Feed Ingredients  

UK PubMed Central (United Kingdom)

Isolates of the most commonly observed salmonella serovars in Norwegian fish feed factories from 1998 to 2000 (Salmonella enterica serovar Agona, S. enterica...Full Text Available

2003-02-01

43

Display of Recombinant Proteins on Bacillus subtilis Spores, Using a Coat-Associated Enzyme as the Carrier?  

UK PubMed Central (United Kingdom)

The display of proteins such as feed enzymes at the surface of bacterial spore systems has a great potential use for animal feed. Feed enzymes increase the digestibility of nutrients, leading to greater...Full Text Available

2010-09-01

44

Value of MRCP using oral Gd-DTPA as negative contrast materials in diagnosis of atypical juxtapapillary duodenal diverticulum  

British Library Electronic Table of Contents (United Kingdom)

Objective To investigate value of magnetic resonance cholangiopancreatography (MRCP) using oral diluted gadolinium (Gd)-diethylenetriamine penta-acetic acid (DTPA) as negative contrast materials in diagnosis of juxtapapillary duodenal diverticulum with atypical imaging features. Methods Nineteen patients with juxtapapillary duodenal diverticula of which imaging findings were atypical underwent MRCP using oral diluted Gd-DTPA as negative contrast materials after conventional MRCP without any oral contrast materials. Results Twenty diverticula were revealed in the 19 patients. At conventional MRCP, the diverticula appeared as rounded lesion with high signal intensity. After oral administration of diluted Gd-DTPA, they disappeared at MRCP. These entities were diagnosed as duodenal diverticula...

2009-01-01

45

Gutteral Pouch Mycosis and Mycotic Encephalitis in a Horse  

UK PubMed Central (United Kingdom)

A case of mycotic encephalitis in a horse with guttural pouch mycosis is described. A liquid pellet feed binder contaminated with Aspergillus sp. and erroneously mixed in a feed concentrate...Full Text Available

1986-03-01

46

Feeding of the megamouth shark (Pisces: Lamniformes: Megachasmidae) predicted by its hyoid arch: A biomechanical approach  

British Library Electronic Table of Contents (United Kingdom)

Abstract Studies of the megamouth shark, one of three planktivorous sharks, can provide information about their evolutionary history. Megamouth shark feeding has never been observed in life animals, but two alternative hypotheses on biomechanics suggest either feeding, i.e., ram feeding or suction feeding. In this study, the second moment of area of the ceratohyal cartilages, which is an indicator of the flexural stiffness of the cartilages, is calculated for 21 species of ram- and suction-feeding sharks using computed tomography. The results indicate that suction-feeding sharks have ceratohyal cartilages with a larger second moment of area than ram-feeding sharks. The result also indicates that the ram-suction index, which is an indicator of relative contribution of ram and suction behavi...

2011-01-01

47

Feed-forward compensation for transient beam loading of the 805 MHz debuncher for the Fermilab linac upgrade  

CERN Document Server

Feed-forward compensation for transient beam loading of the 805 MHz debuncher for the Fermilab linac upgrade

1990-01-01

51

The operating experience for Wolsung Unit 3 commissioning  

International Nuclear Information System (INIS)

This is a slide-based oral presentation given to the COG/IAEA: Fifth technical committee meeting on 'Exchange of operating experience of pressurized heavy water reactors' held in Mangalia, Romania on 7-10 September 1998. Since energization of Wolsung Unit 3 station service transformer on July 12, 1996 a line of initial test program was conducted as follows: 1. ILRT/SIT; 2. Pre-operational and Hot Functional testing with a Light Water and without Fuel in Systems; 3. Load D_2O in Moderator System; 4. Initial fuel loading; 5. Load D_2O in PHT System; 6. Hot Functional Testing with Heavy Water and Fuel in Systems; 7. Criticality and Low Power Physics Testing; 8. Power Ascension Test and, then finally, phase-D test; the plant acceptance test was accomplished after having a Mini-Overhaul to prepare for Commercial Operation. These documents contain not only both overall introduction of commissioning and the first TBN rolling and Synchronization test performed in Hot ...

1998-09-07

52

Oral histories at the Hanford Nuclear Reservation  

Energy Technology Data Exchange (ETDEWEB)

The founding of the Hanford Engineering Works to produce plutonium is described. The 45-year defense mission has now been replaced with a peaceful mission, that of being the first site for massive cleanup of the 45-year nuclear waste. In order to establish a remedial investigation and feasibility plan, a process of discovery named the Technical Baseline Report must be performed; the task of this process is to discover all that is known about a proposed cleanup site (what the waste was, where did it go). When none of the documentation can answer the question, oral history is utilized. Some of the problems associated with the conduct of oral history interviews are described, particularly Hanford`s legacy of secrecy.

1992-03-01

53

Giving voice to the past: digitizing oral history  

British Library Electronic Table of Contents (United Kingdom)

Purpose - The purpose of this paper is to describe the processes and procedures utilized by Jacksonville State University's Houston Cole Library to digitize an oral history collection and provide access to it through the Library's catalog, web presence, and the state-wide digital repository initiative, Alabama Mosaic (see www.alabamamosaic.org). Design/methodology/approach - The paper is based on the Library's experiences in acquiring, digitizing, creating metadata for and making accessible a collection of oral histories. Findings - The paper describes the obstacles overcome, issues encountered, procedures established, and ramifications of the project. Practical implications - Many institutions are currently digitizing unique collections as part of repository initiatives, both institutiona...

2009-01-01

54

Vehicle-Dependent Disposition Kinetics of Fluoranthene in Fisher-344 Rats  

UK PubMed Central (United Kingdom)

The objective of this study was to evaluate how the vehicles of choice affect the pharmacokinetics of orally administered Fluoranthene [FLA] in rats. Fluoranthene is a member of the family of...Full Text Available

2008-03-01

55

The Development of a Dental Diagnostic Terminology  

UK PubMed Central (United Kingdom)

There is no commonly accepted standardized terminology for oral diagnoses. The purpose of this article is to report the development of a standardized dental diagnostic terminology by a work...Full Text Available

2011-01-01

56

The Contributions of the American Military Working Dog in ...  

Science.gov (United States)

... written history concerning the use of the military working dogs in Vietnam. ... oral) to compile a historical account of the military working dog in Vietnam ...

1998-06-05

57

The Case for Reactive Mass Oral Cholera Vaccinations  

UK PubMed Central (United Kingdom)

IntroductionThe outbreak of cholera in Zimbabwe intensified interest in the control and prevention of cholera. While there is agreement that safe water, sanitation, and personal...Full Text Available

59

Pharmacokinetic and pharmacodynamic properties of an oral formulation of the histone deacetylase inhibitor Belinostat (PXD101)  

British Library Electronic Table of Contents (United Kingdom)

Purpose The primary objective of this sub-study, undertaken as an extension to the previously reported phase-I study, was to explore the feasibility, tolerability and pharmacokinetics (PK) of belinostat when administered by the oral route. Preliminary pharmacodynamic (PD) studies were also performed to enable comparison of the biological effects of the oral and intravenous formulations. Patients and methods Oral belinostat was administered in a range of doses and schedules (once, twice or thrice daily), on either day 1 or days 1?5, of the second or a subsequent treatment cycle in 15 patients who were included in the phase-I trial of intravenous belinostat. Serial blood samples were collected for PK and PD (histone acetylation) analyses, and the results compared with corresponding analyses ...

2011-01-01

60

Oral Exposure to Bisphenol A Increases Dimethylbenzanthracene-Induced Mammary Cancer in Rats  

UK PubMed Central (United Kingdom)

BackgroundBisphenol A (BPA) is widely used in the manufacture of polycarbonate plastics, including infant formula bottles.ObjectivesBased on the...Full Text Available

2009-06-01

61

Hispanic Cultural Influences on Medical Practice  

UK PubMed Central (United Kingdom)

Because the proportion of Hispanic patients is increasing rapidly, most physicians are now coming into daily contact with Hispanics. In addition to obvious difficulty with oral communication, Hispanics...Full Text Available

1983-10-01

62

Expression and regulation of the NALP3 inflammasome complex in periodontal diseases  

UK PubMed Central (United Kingdom)

Periodontitis is an infectious process characterized by inflammation affecting the supporting structures of the teeth. Porphyromonas gingivalis is a major oral bacterial species implicated...Full Text Available

2009-09-01

64

Controlling Endemic Cholera with Oral Vaccines  

UK PubMed Central (United Kingdom)

BackgroundAlthough advances in rehydration therapy have made cholera a treatable disease with low case-fatality in settings with appropriate medical care, cholera continues...Full Text Available

2007-11-01

65

An in Vitro Antimicrobial Activity of Ten Iranian-Made Toothpastes  

UK PubMed Central (United Kingdom)

Background:Antimicrobial agents have been used as a chemotherapeutic agent to improve oral health. This in vitro study was carried out to determine the antimicrobial activity...Full Text Available

2009-01-01

66

7th international symposium on photosynthetic prokaryotes. Abstracts  

Energy Technology Data Exchange (ETDEWEB)

This book contains the abstracts of all the presentations made either in oral or poster form, at the VII International Symposium on Photosynthetic Prokaryotes.

1991-12-31

67

7th international symposium on photosynthetic prokaryotes  

Energy Technology Data Exchange (ETDEWEB)

This book contains the abstracts of all the presentations made either in oral or poster form, at the VII International Symposium on Photosynthetic Prokaryotes.

1991-01-01

69

Clonidine, octopaminergic receptor agonist, reduces protein feeding in the blow fly, Phormia regina (Meigen)  

British Library Electronic Table of Contents (United Kingdom)

Results in this study are consistent with those of Murdock and his colleagues who clearly demonstrated that clonidine, an agonist of octopaminergic receptors in some insects, significantly increases sucrose feeding. Their studies, however, did not examine the effect of clonidine on protein feeding. Injection of a 20mg/ml/fly dose of clonidine significantly reduces protein feeding in both sexes of Phormia regina, instead of stimulating feeding as is observed with carbohydrate feeding. The manner in which the flies are fed prior to starvation and the method of testing influences the amounts of diet consumed. It is proposed that the biogenic amines influence the state of hunger (i.e., protein versus carbohydrates) while other chemicals and neural mechanisms (i.e., such as sulfakinins and stre...

2007-01-01

70

Transcription from the SV40 early-early and late-early overlapping promoters in the absence of DNA replication.  

UK PubMed Central (United Kingdom)

Transcription for a hybrid SV40 promoter-beta globin coding sequence recombinant initiates from both early-early (EE) and late-early (LE) SV40 start sites (EES and LES) in the absence of DNA replication....Full Text Available

1983-01-01

71

Serum ferritin in recurrent oral ulceration  

Energy Technology Data Exchange (ETDEWEB)

A sensitive radio-assay for ferritin was developed and used to examine serum ferritin levels in 105 patients with recurrent oral ulceration (ROU), 41 patients with Behcet's syndrome (BS), 42 with other ulcerative oral lesions, 35 patients with non-ulcerative oral lesions and in 78 controls. Ferritin levels increased with age and were significantly higher in males than females. The mean ferritin concentrations in male patients with ROU, BS or with other oral ulcers were significantly reduced in comparison with controls, and in female patients were significantly reduced in those with major aphthous ulcers. The prevalence of low serum ferritin levels was about 8% in patients with ROU, 15% in BS and 9.5% in patients with other ulcerative oral lesions, compared with less than 3% in patients with non-ulcerative oral disorders and in controls. Most of the ...

1983-01-01

72

International conference on advances in destructive and non-destructive analysis for environmental monitoring and nuclear forensics. Book of extended synopses  

International Nuclear Information System (INIS)

This document contains 59 extended synopses of the presentations delivered at the conference during oral and poster sessions. The four oral sessions were devoted to: The role of nuclear forensics in combating illicit trafficking and nuclear terrorism; Current capabilities and past experiences; Analytical techniques; and Challenges and alternative approaches. Each of the synopses was indexed separately

2002-10-21

73

10% low density corn-oil emulsion oral contrast agent for abdominal computed tomography  

Energy Technology Data Exchange (ETDEWEB)

CT of the gastrointestinal tract is commonly performed after administration of a high-density diluted iodinated oral contrast material. However, because if inadequate mixing of the contrast material with the gastrointestinal contents, pseudotumor and poor mucosal visualization are frequently shown on abdominal CT. To overcome these problem, 10% corn oil emulsion (COE) is tested as an alternative oral contrast agent in 40 patients. We analyse patients tolerance, gastric mucosal visualization and discrimination of pancreas from the duodenal C-loop to 10% COE in 40 patients compared with those obtained from 35 patients, who was received high-density diluted iodinated oral contrast agent (gastrografin). The results are as follows : 1. Patients' tolerance to 10% COE is similar to that to conventional oral contrast agent. 2. Image of the gastric mucosa from patients receiving 10% COE is superior to ...

1990-10-15

74

10% low density corn-oil emulsion oral contrast agent for abdominal computed tomography  

International Nuclear Information System (INIS)

CT of the gastrointestinal tract is commonly performed after administration of a high-density diluted iodinated oral contrast material. However, because if inadequate mixing of the contrast material with the gastrointestinal contents, pseudotumor and poor mucosal visualization are frequently shown on abdominal CT. To overcome these problem, 10% corn oil emulsion (COE) is tested as an alternative oral contrast agent in 40 patients. We analyse patients tolerance, gastric mucosal visualization and discrimination of pancreas from the duodenal C-loop to 10% COE in 40 patients compared with those obtained from 35 patients, who was received high-density diluted iodinated oral contrast agent (gastrografin). The results are as follows : 1. Patients' tolerance to 10% COE is similar to that to conventional oral contrast agent. 2. Image of the gastric mucosa from patients receiving 10% COE is superior to that ...

1990-10-01

75

EARLY ENTRANCE COPRODUCTION PLANT  

Science.gov (United States)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended ...

2004-01-12

76

Adaptation of oral streptococci to low pH.  

Science.gov (United States)

The strategies employed by oral streptococci to resist the inimical influences of acidification reflect the diverse and dynamic niches of the human mouth. All of the oral streptococci are capable of rapid degradation of sugar to acidic end-products. As a result, the pH value of their immediate environment can plummet to levels where glycolysis and growth cease. At this point, the approaches for survival in acid separate the organisms. Streptococcus mutans, for example, relies on its F-ATPase, to protect itself from acidification by pumping protons out of the cells. S. salivarius responds by degrading urea to ammonia and S. sanguis produces ammonia by arginolysis. The mechanisms by which these organisms regulate their particular escape route are now being explored experimentally. The picture that emerges is that the acid-adaptive regulatory mechanisms of the oral streptococci differ markedly from those employed by ...

2000-01-01

77

Unbiased Transcriptional Comparisons of Generalist and Specialist Herbivores Feeding on Progressively Defenseless Nicotiana attenuata Plants  

UK PubMed Central (United Kingdom)

BackgroundHerbivore feeding elicits dramatic increases in defenses, most of which require jasmonate (JA) signaling, and against which specialist herbivores are thought to be better...Full Text Available

78

THE ROLE OF SALIVA IN TICK FEEDING  

UK PubMed Central (United Kingdom)

When attempting to feed on their hosts, ticks face the problem of host hemostasis (the vertebrate mechanisms that prevent blood loss), inflammation (that can produce itching or pain and thus...Full Text Available

79

Salmonella enterica in Commercial Swine Feed and Subsequent Isolation of Phenotypically and Genotypically Related Strains from Fecal Samples?  

UK PubMed Central (United Kingdom)

The purpose of this study was to determine the occurrence and genotypic relatedness of Salmonella enterica isolates recovered from feed and fecal samples in commercial swine production...Full Text Available

2010-11-01

80

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice  

UK PubMed Central (United Kingdom)

Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight gain; however, the...Full Text Available

2011-04-01

81

Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice  

UK PubMed Central (United Kingdom)

Insulin resistance plays a central role in type 2 diabetes and obesity, which develop as a consequence of genetic and environmental factors. Dietary changes including high fat diet (HFD) feeding promotes...Full Text Available

82

Percutaneous duodenostomy - alternative route for enteral nutrition  

International Nuclear Information System (INIS)

Percutaneous translumbar duodenostomy for enteral feeding was performed in one patient with nutritional difficulties. No complication was encountered. The procedure can be an alternative to percutaneous gastrostomy and jejunostomy for enteral feeding in special situations. (orig.).

83

Outbreak of acute colitis on a horse farm associated with tetracycline-contaminated sweet feed.  

UK PubMed Central (United Kingdom)

Exposure of a group of horses to tetracycline-contaminated feed resulted in acute colitis and subsequent death in one horse and milder diarrhea in 3 others. The most severely affected animal demonstrated...Full Text Available

1999-10-01

84

Nutrient needs and feeding of premature infants. Nutrition Committee, Canadian Paediatric Society.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To recommend appropriate intake of nutrients, food sources and feeding practices for premature infants. OPTIONS: Unfortified milk from the premature infant's own mother, fortified milk from...Full Text Available

1995-06-01

85

Mycotoxins in fungal contaminated samples of animal feed from western Canada, 1982-1994.  

UK PubMed Central (United Kingdom)

Feed samples from 94 cases involving fungal contamination and suspected mycotoxicosis of farm animals in western Canada were examined during 1982-1994 to assess the incidence of mycotoxins. Samples...Full Text Available

1997-01-01

86

Evolution of feeding specialization in Tanganyikan scale-eating cichlids: a molecular phylogenetic approach  

UK PubMed Central (United Kingdom)

BackgroundCichlid fishes in Lake Tanganyika exhibit remarkable diversity in their feeding habits. Among them, seven species in the genus Perissodus are known for...Full Text Available

87

Effect of discriminative plant-sugar feeding on the survival and fecundity of Anopheles gambiae  

UK PubMed Central (United Kingdom)

BackgroundA previous study showed for Anopheles gambiae s.s. a gradation of feeding preference on common plant species growing in a malaria holoendemic area in western...Full Text Available

88

Distribution, Frequency, and Diversity of Bacillus thuringiensis in an Animal Feed Mill  

UK PubMed Central (United Kingdom)

Bacillus thuringiensis was isolated from 36 of 50 residue samples obtained from an animal feed mill (a stored-product environment). Of 710 selected colonies having Bacillus...Full Text Available

1992-04-01

89

Council tax valuation band predicts breast feeding and socio-economic status in the ALSPAC study population  

UK PubMed Central (United Kingdom)

BackgroundBreast-feeding rates in the UK are known to vary by maternal socio-economic status but the latter function is imperfectly defined. We test if CTVB (Council Tax Valuation...Full Text Available

90

Breast feeding, eczema, asthma, and hayfever.  

UK PubMed Central (United Kingdom)

The association of breast feeding with rates of atopic illness during the first five years of life was assessed in a national study of 13 135 children studied during the first week and at age 5 years....Full Text Available

1983-06-01

91

A functional comparison of the hyolingual complex in pygmy and dwarf sperm whales (Kogia breviceps and K. sima), and bottlenose dolphins (Tursiops truncatus)  

UK PubMed Central (United Kingdom)

The function of the hyolingual complex in three odontocete species was investigated to compare adaptations of divergent feeding strategies, suction and ram feeding. Pygmy and dwarf sperm whales, members...Full Text Available

2007-07-01

92

Safety analysis and justification for modification of auxiliary feed-water system in Daya Bay Nuclear Power Plant  

International Nuclear Information System (INIS)

The major feed-water line break accident is re-analyzed, which is based on Guangdong Daya Bay nuclear power station final safety analysis report, to justify the impacts of the decreasing of auxiliary feed-water flow rate on the safety margin in Daya Bay. The results showed that the accident analysis can meet the demands of acceptance criteria with the auxiliary feed-water flowrate decreasing from 45 m"3/h to 41.8 m"3/h, and enough safety margin is still retained

2002-06-01

93

Mathematical Modeling and Optimization Studies on ...  

Science.gov (United States)

... 1]. Results and Discussion A cross section of liquid feed direct borohydride fuel cell model was created and studied. The ...

2010-05-12

94

Evaluation of the fluid force in main feed water control valve for APWRs  

International Nuclear Information System (INIS)

... 2432 v. 43(1) SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS

2006-01-01

98

Broth recycling to reduce process noise resulting from concentrated substrate addition in fed-batch cultivation of Escherichia coli.  

Science.gov (United States)

In this work feed hardware for fed-batch cultivation is presented (broth recycle feed injection system or BRFIS). BRFIS proved superior to conventional submerged or dripped feed systems in reducing dissolved oxygen (DO) oscillations during Escherichia coli fed-batch cultivation (5 min coefficient of variation of 0.7% for BRFIS as compared to 26% or greater for conventional feeding hardware in a 2 L test reactor). Hence, BRFIS is useful for fed-batch cultivation systems where the DO signal is used in measurement or control. PMID:12675613

99

Multi-scales analysis of the global change impact on the diversity of the aphid communities; Analyse multi-echelle de l'impact du changement global sur la diversite des communautes aphidiennes  

Energy Technology Data Exchange (ETDEWEB)

The primary objective of this project is to investigate the effects of global change on the biodiversity of aphid communities in Western Europe. Biodiversity has been examined at 3 levels: total number of species, phenology and reproductive strategy. Data were provided by EXAMINE, the European suction traps network which has been now operating for 35 years. 392 different species have been identified. At each location, total number of species has been regularly increasing, one additional species being caught every 1 or 2 years depending on location. This is due to introduced species but also to warming which favours rare species. No general trend of increasing density has been detected, but phenological earliness of almost all species (annual date of first appearance in suction traps) is strongly correlated with temperature and especially with mean daily temperature (during more or less long periods of time lying principally in February and March) or number of days ...

2007-07-01

100

Bitumen immobilization of aqueous radwaste by thin-film evaporation  

International Nuclear Information System (INIS)

In the early 1980s, AECL built a Waste Treatment Centre (WTC) for managing low-level solid and aqueous liquid wastes for converting CANDU wastes. At present, two liquid waste streams are being treated at the WTC. The liquid waste streams are volume-reduced by a combination of continuous crossflow microfiltration (MF), spiral wound reverse osmosis (SWRO) and tubular reverse osmosis (TRO) membrane technologies. The concentrate produced from the TRO system and the volume-reduced MF backwash solutions are evaporated while simultaneously adding bitumen in a thin-film evaporator. A water-free product of chemical and radiochemical salts and bitumen is removed in 200-L galvanized steel drums for storage. The radiation field of product drums on contact typically has a value of 0.5 to 3 R/h depending upon the feed concentration of radioactivity to the evaporator. The total solids content in the 200-L drum ranges from 25 to 35%. Encapsulated in the ...

1996-02-25

101

Load requirements for maintaining structural integrity of Hanford single-shell tanks during waste feed delivery and retrieval activities  

Energy Technology Data Exchange (ETDEWEB)

This document provides structural load requirements and their basis for maintaining the structural integrity of the Hanford Single-Shell Tanks during waste feed delivery and retrieval activities. The requirements are based on a review of previous requirements and their basis documents as well as load histories with particular emphasis on the proposed lead transfer feed tanks for the privatized vitrification plant.

1999-09-22

102

Keeping chickens: a beginner's guide : Directgov - Environment and greener living  

Wastenet

...Keeping chickens: a beginner's guide : Directgov - Environment and greener living chickens, feeding chickens, egg marking, registering a ...flock, battery hens Chickens; Department for Environment, Food and Rural Affairs; Registrations; Animals; Livestock; Local government; Local ...authorities A guide for people keeping chickens on the laws for registering and feeding them, and how to spot key diseases. A ...guide for people keeping chickens on the laws for registering and feeding them, and how to spot key diseases. Keeping chickens: ...

103

Lugworm exclusion experiment: Responses by deposit feeding worms to biogenic habitat transformations  

British Library Electronic Table of Contents (United Kingdom)

On six 400 m2 plots over 3 years, we excluded the sessile subduction and conveyer-belt feeding polychaete Arenicola marina which generates a pit-and-mound topography at the sediment surface from intertidal sands near the island of Sylt, Germany. This experiment was used to test whether other abundant deposit feeding polychaetes (the discretely motile and surface feeding ragworm Nereis diversicolor and the subsurface-feeding, motile orbiniid polychaete Scoloplos cf. armiger) benefit from competitive release. Ragworms took advantage from the absence of lugworms. Presumably they responded to a more stable and nutritious surface layer at lugworm exclusion plots (relief from inhibitive bioturbation). Contrary to this, S. cf. armiger was negatively affected by the exclusion of A. marina. It may ...

2006-01-01

104

Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese postmenopausal women  

British Library Electronic Table of Contents (United Kingdom)

Objectives: Evaluate the effect of diet, physical exercise, and a daily oral intake of a soy isoflavones extract (Fisiogen) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daidzein and 3.2mg of glicitein) on leptin and other adipokines plasma levels in healthy obese postmenopausal women. Methods: A multicentric randomized longitudinal prospective cohort study was conducted in a sample of 87 healthy obese postmenopausal women. Patients were randomly assigned to a 1200kcal diet and exercise group (control group) or a group of 1200kcal diet, exercise, and daily oral intake of daily oral intake of a soy isoflavones extract (Fisiogen) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daid...

2011-01-01

105

Oral rush desensitization to egg: efficacy and safety  

British Library Electronic Table of Contents (United Kingdom)

Summary Background Current management of egg allergy relies on egg elimination from the diet. It does not protect patients from reactions after accidental ingestion of the food and it has a negative influence on quality of life. To solve these problems, some desensitization protocols have been described that are safe and effective, but only one study of a rush regimen for egg with a small patient sample has been published. Objective To evaluate the safety, efficacy and immunologic effects of an oral rush desensitization protocol for immediate egg allergy. Methods Subjects aged 5 years or older with symptomatic IgE-mediated allergy to hen's egg underwent a 5-day oral tolerance induction regimen and were subsequently maintained on a regular egg intake. The variables studied were the reaction...

2011-01-01

106

Experiments toward medical management of radionuclides in the gut: effect of deferoxamine on "2"3"8Pu(NO_3)_4 absorption from rat gut  

International Nuclear Information System (INIS)

Deferoxamine (DFA) (250 mg/kg), orally administered to rats, decreased Pu absorption from orally administered "2"3"8Pu(NO_3)_4 by about 1/3. The calcium salt of diethylenetriaminepentaacetic acid (Ca-DTPA), given orally 5 to 10 min after the Pu, increased absorption about four times. DFA given 10 min before the DTPA decreased the effect of the latter by a factor of two. Deferoxamine administration prior to inhalation treatment of man with DTPA may be one way to decrease possible DTPA-enhanced gut absorption of Pu.

1977-05-01

107

Treatment of Produced Waters Using a Surfactant Modified Zeolite/Vapor Phase Bioreactor System  

Energy Technology Data Exchange (ETDEWEB)

This report summarizes work performed on this project from October 2004 through March 2005. In previous work, a surfactant modified zeolite (SMZ) was shown to be an effective system for removing BTEX contaminants from produced water. Additional work on this project demonstrated that a compost-based biofilter could biodegrade the BTEX contaminants found in the SMZ regeneration waste gas stream. However, it was also determined that the BTEX concentrations in the waste gas stream varied significantly during the regeneration period and the initial BTEX concentrations were too high for the biofilter to handle effectively. A series of experiments were conducted to determine the feasibility of using a passive adsorption column placed upstream of the biofilter to attenuate the peak gas-phase VOC concentrations delivered to the biofilter during the SMZ regeneration process. In preparation for the field test of the SMZ/VPB treatment system in New Mexico, a pilot-scale SMZ system was also ...

2005-03-11

108

Genes related to the very early stage of ConA-induced fulminant hepatitis: a gene-chip-based study in a mouse model  

UK PubMed Central (United Kingdom)

BackgroundDue to the high morbidity and mortality of fulminant hepatitis, early diagnosis followed by early effective treatment is the key for prognosis improvement. So far, little...Full Text Available

109

Variation in Nicotine Consumption in Inbred Mice Is Not Linked to Orosensory Ability  

UK PubMed Central (United Kingdom)

Genetic studies of nicotine addiction in mice have utilized the oral self-administration model. However, it is unclear if strain differences in nicotine consumption are influenced by variation in bitter...Full Text Available

2009-01-01

110

Use of oral miltefosine for cutaneous leishmaniasis in Canadian soldiers returning from Afghanistan  

UK PubMed Central (United Kingdom)

Old world cutaneous leishmaniasis (CL) is caused by Leishmania major and Leishmania tropica, and is endemic to several Asian and Middle-Eastern countries where the...Full Text Available

2008-11-01

111

The future of dentistry: new challenges, new directions.  

UK PubMed Central (United Kingdom)

The challenge to our profession today is to improve the quality of oral health while overcoming both extrinsic and intrinsic factors which may adversely affect our progress toward this goal. The combined...Full Text Available

1990-05-01

112

The Use of Zirconium and Feldspathic Porcelain in the Management of the Severely Worn Dentition: A Case Report  

UK PubMed Central (United Kingdom)

The management of the interim phase of a complete oral rehabilitation in patients with severely worn dentition is often challenging due to the loss of occlusal vertical dimension, loss of tooth structure,...Full Text Available

2009-01-01

113

The Relationship Between the Stomatognathic System and Body Posture  

UK PubMed Central (United Kingdom)

In recent years, many researchers have investigated the various factors that can influence body posture: mood states, anxiety, head and neck positions, oral functions (respiration,...Full Text Available

2009-01-01

114

Synthetic progestins differentially promote or prevent DMBA-induced mammary tumors in Sprague-Dawley rats  

UK PubMed Central (United Kingdom)

Recent clinical trials demonstrate that combined oral dosing with estrogen and progestin increases the incidence of breast cancer in post-menopausal women. Similarly, in a rat model system of...Full Text Available

2010-09-01

115

Removable Partial Denture in a Cleft Lip and Palate Patient: A Case Report  

UK PubMed Central (United Kingdom)

This clinical report described the oral rehabilitation of a cleft lip and palate patient with removable partial denture. Although implant-supported fixed treatment was presented as part of the optimum...Full Text Available

2008-10-01

116

Preterm low birthweight and the role of oral bacteria  

UK PubMed Central (United Kingdom)

Preterm and low birthweight (PTLBW) continues to be a major cause of mortality and morbidity across the world. In recent years, maternal periodontal disease has been implicated as a risk factor for...Full Text Available

117

Preparation and In Vivo Evaluation of Indomethacin Loaded True Nanoemulsions  

UK PubMed Central (United Kingdom)

Indomethacin, a potent nonsteroidal anti-inflammatory drug, has been used in the treatment of various kinds of pains, inflammation and arthritis. However, oral administration of indomethacin produces...Full Text Available

2010-03-30

118

Preparation and Evaluation of Buccal Bioadhesive Films Containing Clotrimazole  

UK PubMed Central (United Kingdom)

Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms. The aim of present study was to prepare...Full Text Available

119

Physicochemical Characterization of Berberine Chloride: A Perspective in the Development of a Solution Dosage Form for Oral Delivery  

UK PubMed Central (United Kingdom)

The objective of the present research was to evaluate the physicochemical characteristics of berberine chloride and to assess the complexation of drug with 2-hydroxypropyl-β-cyclodextrin (HPβCD),...Full Text Available

120

PREVALENCE OF MYCOPLASMA AGASSIZII AND CHELONIAN HERPESVIRUS IN CAPTIVE TORTOISES (TESTUDO SP.) IN THE UNITED KINGDOM  

Science.gov (United States)

... the tropism of both mycoplasmas and herpesviruses for epithelial tissue still indicate oral swabs to be the most ... feces.18 Alphaherpesviruses show a marked tropism for epithelial tissue, with viral rep...

121

Nonhuman Primate Model for Listeria monocytogenes-Induced Stillbirths  

UK PubMed Central (United Kingdom)

Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging from 106 to 1010 CFU....Full Text Available

2003-03-01

122

Multiple-Dose Safety, Tolerability, and Pharmacokinetics of Oral Nemonoxacin (TG-873870) in Healthy Volunteers?  

UK PubMed Central (United Kingdom)

Nemonoxacin (TG-873870) is a novel nonfluorinated quinolone with broad-spectrum activities against Gram-positive and Gram-negative aerobic, anaerobic, and atypical pathogens, as well as against methicillin-resistant...Full Text Available

2010-01-01

123

Induction of nonspecific tolerance to endotoxins reduces the alveolar bone resorption in ligature-treated rats.  

UK PubMed Central (United Kingdom)

Previous experimental data from various laboratories indicate that endotoxin of gram-negative oral microorganisms might be one of the most important bacterial products involved in bone resorption during...Full Text Available

1983-02-01

124

Inducible Azole Resistance Associated with a Heterogeneous Phenotype in Candida albicans  

UK PubMed Central (United Kingdom)

The development of azole resistance in Candida albicans is most problematic in patients with AIDS who receive long courses of drug for therapy or prevention of oral candidiasis. Recently,...Full Text Available

2001-01-01

125

Hepatotoxicity of High Oral Dose (-)-Epigallocatechin-3-Gallate in Mice  

UK PubMed Central (United Kingdom)

The tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been studied for chronic disease preventive effects, and is marketed as part of many dietary supplements. However, case reports have...Full Text Available

2010-01-01

126

Head and Neck Sentinel Lymph Node Biopsy: Current State of the Art  

UK PubMed Central (United Kingdom)

Sentinel node biopsy is an alternative to elective neck dissection for the management of T1/T2 oral and oro-pharyngeal squamous cell carcinomas and is also finding application to head and neck cancer...Full Text Available

127

Gestational Weight Gain and Risk of Gestational Diabetes Mellitus  

UK PubMed Central (United Kingdom)

OBJECTIVETo estimate the relationship between the rate of gestational weight gain before the 50-g, 1-hour oral glucose challenge test screening for gestational diabetes...Full Text Available

2010-03-01

128

From Leningrad to the day-care center. The ubiquitous Giardia lamblia.  

UK PubMed Central (United Kingdom)

Giardiasis is recognized as a worldwide public health problem. Seroprevalence data from both the developing and developed world show high rates of carriage in populations at risk for fecal-oral transmission,...Full Text Available

1990-08-01

129

From Attachment to Damage: Defined Genes of Candida albicans Mediate Adhesion, Invasion and Damage during Interaction with Oral Epithelial Cells  

UK PubMed Central (United Kingdom)

Candida albicans frequently causes superficial infections by invading and damaging epithelial cells, but may also cause systemic infections by...Full Text Available

130

First-Time Generics - August 2005  

Science.gov (United States)

... 1, CLONAZEPAM ORALLY DISINTEGRATING TABLETS, 0.125 MG, 0.25 MG, 0.5 MG, 1 MG, AND 2 MG, KALI LABORATORIES, INC. KLONOPIN RAPIDLY DISINTEGRATING TABLETS, 8/3/2005 ...

131

Evaluating the Suitability of Using Rat Models for Preclinical Efficacy and Side Effects with Inhaled Corticosteroids Nanosuspension Formulations  

UK PubMed Central (United Kingdom)

Inhaled corticosteroids (ICS) are often prescribed as first-line therapy for patients with asthma Despite their efficacy and improved safety profile compared with oral corticosteroids, the potential...Full Text Available

132

Effects of Depot Medroxyprogesterone Acetate and 20 ?g Oral Contraceptives on Bone Mineral Density  

UK PubMed Central (United Kingdom)

OBJECTIVEHormonal contraceptives may adversely affect bone mineral density . However, racial differences and the reversibility of these changes are poorly understood....Full Text Available

2008-10-01

133

Detection of Sub-Clinical CWD Infection in Conventional Test-Negative Deer Long after Oral Exposure to Urine and Feces from CWD+ Deer  

UK PubMed Central (United Kingdom)

BackgroundChronic wasting disease (CWD) of cervids is a prion disease distinguished by high levels of transmissibility, wherein bodily fluids and excretions are thought to play an...Full Text Available

134

Comparison of oral and vaginal metronidazole for treatment of bacterial vaginosis in pregnancy: impact on fastidious bacteria  

UK PubMed Central (United Kingdom)

BackgroundBacterial vaginosis (BV) is a common condition that is associated with preterm birth and acquisition of complex communities of vaginal bacteria that include several fastidious...Full Text Available

135

Chylopericardium after cardiac surgery can be treated successfully by oral dietary manipulation: a case report  

UK PubMed Central (United Kingdom)

We report a case of chylopericardium after ascending aorta and aortic valve replacement, which presented as late tamponade. We discuss the various treatment options in this rare condition which can...Full Text Available

136

Catalyst preparation and characterization, session 1  

Energy Technology Data Exchange (ETDEWEB)

The abstracts of all the presentations (1 plenary session, 2 keynotes, 52 oral communications, 496 posters) of the thematic session 1: 'catalyst preparation and characterization' are gathered in the CD-Rom of the conference. The main application described concerns the petroleum industry. (O.M.)

2004-07-01

137

Bleeding during cancer treatment: MedlinePlus Medical Encyclopedia  

Science.gov (United States)

- flushing Chemotherapy - what to ask your doctor Dry Mouth Oral mucositis Peripherally inserted central catheter Radiation therapy - what to ask your doctor Safe drinking during...

2011-08-09

138

Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models  

UK PubMed Central (United Kingdom)

Antinociceptive and anti-inflammatory activities of the ethanol extract from Annona muricata L. leaves were investigated in animal models. The extract delivered per oral route (p.o.)...Full Text Available

139

Antimicrobial susceptibilities of bacteria associated with periodontal disease.  

UK PubMed Central (United Kingdom)

A total of 193 bacterial strains were tested for their susceptibilities to 14 antimicrobial agents. Penicillin G was active at 2 U/ml against 98% of the oral isolates. Other antibiotics with good activity...Full Text Available

1983-03-01

140

Analysis of trigeminal nerve disorders after oral and maxillofacial intervention  

UK PubMed Central (United Kingdom)

BackgroundQuantitative sensory testing (QST) is applied to evaluate somatosensory nerve fiber function in the spinal system. This study uses QST in patients with sensory dysfunctions...Full Text Available

141

An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study  

UK PubMed Central (United Kingdom)

BackgroundAdenoid Cystic Carcinoma (ACC) is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly...Full Text Available

142

A population pharmacokinetic meta-analysis of maraviroc in healthy volunteers and asymptomatic HIV-infected subjects  

UK PubMed Central (United Kingdom)

AimsTo develop a population pharmacokinetic model for maraviroc, a noncompetitive CCR5 antagonist, after oral administration of tablets to healthy volunteers and asymptomatic HIV-infected...Full Text Available

2008-04-01

143

A Murine Model to Study the Antibacterial Effect of Copper on Infectivity of Salmonella Enterica Serovar Typhimurium  

UK PubMed Central (United Kingdom)

This study investigated the effect of copper as an antibacterial agent on the infectivity of Salmonella enterica serovar Typhimurium. Mice were infected orally with a standardized dose...Full Text Available

2011-01-01

144

A Double Blind, Placebo-Controlled, Randomized Crossover Study of the Acute Metabolic Effects of Olanzapine in Healthy Volunteers  

UK PubMed Central (United Kingdom)

Background and RationaleAtypical antipsychotics exhibit metabolic side effects including diabetes mellitus and obesity. The adverse events are preceded by acute worsening of oral...Full Text Available

145

A Comparison of intra-oral digital imaging modalities: Charged Couple Device versus Storage Phosphor Plate  

UK PubMed Central (United Kingdom)

BackgroundThis in vitro study was conducted to compare the accuracy of two digital image receptors in identifying the location of tip of a fine endodontic file and radiographic apex...Full Text Available

2010-11-01

146

Removal of "2"3"9Pu from the rat with an orally administered chelon  

International Nuclear Information System (INIS)

The oral administration of 2,3-dihydroxybenzoic acid (DHB) to rats injected intravenously 1 hr previously with "2"3"9Pu citrate caused an increase in urinary excretion of Pu about 8 times that of animals treated with 0.9% NaCl (controls). Liver retention of Pu was decreased from 18% at 2 days in the control animals to 11% in DHB-treated rats. The skeletal retention was similarly reduced from 56% in the control group to 40% in the DHB-treated animals.

1977-05-01

147

Palliation of radiation-related mucositis  

Energy Technology Data Exchange (ETDEWEB)

Oral mucositis associated with head and neck radiotherapy can substantially hinder completion of cancer therapy. Alleviation of this often severe stomatitis can provide enhanced patient comfort and facilitate appropriate care. A double-blind format was used in a pilot project to measure, against a control rinse, the effectiveness of an oral rinse consisting of hydrocortisone, nystatin, tetracycline, and diphenhydramine in controlling radiation-related mucositis. A combination of clinical evaluation and patient responses to a questionnaire was used to judge the results of the topical medications. Patients using the experimental medication developed less mucositis than did patients in the control group.

1990-01-01

148

EFFECTS OF QUARTZ PARTICLE SIZE AND SUCROSE ADDITION ON MELTING BEHAVIOR OF A MELTER FEED FOR HIGH-LEVEL GLASS  

Energy Technology Data Exchange (ETDEWEB)

The behavior of melter feed (a mixture of nuclear waste and glass-forming additives) during waste-glass processing has a significant impact on the rate of the vitrification process. We studied the effects of silica particle size and sucrose addition on the volumetric expansion (foaming) of a high-alumina feed and the rate of dissolution of silica particles in feed samples heated at 5 C/min up to 1200 C. The initial size of quartz particles in feed ranged from 5 to 195 {micro}m. The fraction of the sucrose added ranged from 0 to 0.20 g per g glass. Extensive foaming occurred only in feeds with 5-{micro}m quartz particles; particles {ge}150 {micro}m formed clusters. Particles of 5 {micro}m completely dissolved by 900 C whereas particles {ge}150 {micro}m did not fully dissolve even when the temperature reached 1200 C. Sucrose addition had virtually zero impact on both foaming and the ...

2010-07-28

149

The early phase change Gene in Maize  

UK PubMed Central (United Kingdom)

Recessive mutations of the early phase change (epc) gene in maize affect several aspects of plant development. These mutations were identified initially because of...Full Text Available

2002-01-01

150

Aortic non communicating dissections. A study with helical CT  

International Nuclear Information System (INIS)

The evaluate the signs of aortic intramural hematoma with helical CT and the diagnostic role of this technique in patients with this condition. It was reviewed the CT findings of 396 patients submitted to emergency examinations for suspected aortic dissection from 1995 to 1999. Only 18 patients (6 women and 12 men) had CT signs of aortic intramural hematoma. Helical CT studies were carried out with the following parameters: slice thickness 10 mm, reconstruction index 10, feed 1.5 mm, conventional algorithm with minimum values of 130 kV and 125mA. All patients were examined with dynamic contrast-enhanced CT, before and after a power injection of 130 mL ionic contrast material. It was studied: hematoma localization and longitudinal extension; thickness and density of aortic wall; presence and location of intimal calcifications; integrity of intimal wall; hemo mediastinum and/or hemo thorax. Aortic wall thickening appeared as a high density crescent-shaped area at ...

2000-09-01

151

Total skin electron beam therapy followed by adjuvant psoralen/ultraviolet-a light in the management of patients with T1 and T2 cutaneous T-cell lymphoma (mycosis fungoides)  

International Nuclear Information System (INIS)

Purpose: Patients with mycosis fungoides [cutaneous T-cell lymphoma (CTCL)] may benefit from adjuvant therapy after completing total skin electron beam therapy (TSEBT). We report the results for (T1(T2)) CTCL patients treated with adjuvant oral psoralen plus ultraviolet light (PUVA) with respect to overall survival (OS), disease-free survival (DFS), salvage of recurrence, and toxicity. Methods and Materials: Between 1974 and 1993, TSEBT was administered to a total of 213 patients with CTCL. Records were reviewed retrospectively, and a total of 114 patients were identified as having T1 or T2 disease. Radiotherapy was provided via a 6-MeV linac to a total of 36 Gy, 1 Gy/day, 4 days/week, for 9 weeks. Beginning in 1988, patients were offered adjuvant PUVA within 2 months of completing TSEBT. This was started at 0.5-2 J/m"2, 1-2 treatments/week, with a taper over 3-6 months. Therapy then continued once per month. There were 39 T1 and 75 T2 patients. Six T1 (15%) and ...

1997-07-15

152

Serotonin Inhibits Protein Feeding in the Blow Fly, Phormia regina (Meigen)  

British Library Electronic Table of Contents (United Kingdom)

Serotonin is an important signaling molecule involved in the control of feeding in flies and other animals. In this study, a potential neurohemal release site for serotonin and the effects of exogenous serotonin on protein feeding were examined in the black blow fly, Phormia regina. A dense network of varicose neural processes exhibiting serotonin-like immunoreactivity was identified on the dorsal region of the thoracico-abdominal ganglion in P. regina. This dorsal region of the central nervous system is a likely site for the release of serotonin into the hemolymph. Circulating serotonin may have multiple systemic effects on fly physiology, including modulating or regulating feeding related processes and diuresis. Injections of exogenous serotonin reduced protein meal size in female flies ...

2009-01-01

153

Healthy Nutrition: Breastfeeding  

Medline Plus

Ages & Stages Prenatal Delivery & Beyond Decisions to Make Baby: 0-12 mos. Bathing & Skin Care Breastfeeding Crying & Colic Diapers & Clothing Feeding & Nutrition Preemie ...

154

Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine  

UK PubMed Central (United Kingdom)

AbstractThe efficacy of tilmicosin administered in the feed to control Actinobacillus pleuropneumoniae infections in pigs was evaluated through a multisite, multitrial...Full Text Available

2004-01-01

158

Duodenal ileus caused by a calf feeding nipple in a cow  

UK PubMed Central (United Kingdom)

BackgroundThe aim of this report was to describe duodenal obstruction caused by a rubber foreign body in a cow.Case PresentationThe clinical, biochemical...Full Text Available

159

Deforestation in Mato Grosso, Brazil - NASA  

Science.gov (United States)

Deforestation in Mato Grosso, Brazil. atom_author. atom_name, Jesse Allen. atom_link. kml_href, http://earthobservatory.nasa.gov/Feeds/GoogleEarth/ ...

160

Central Venous Access Catheters (CVAC) and Gastrostomy (Feeding) Tubes  

Science.gov (United States)

... of CVACs, including tunneled catheters (Hickman or Broviac), peripherally inserted central catheters (also called PICC lines or long lines), ...

166

Creation of the BioBank, Early Detection and Discovery Biomarkers  

Science.gov (United States)

Pancreatic Cancer; Head and Neck Cancer; Breast Cancer

2011-04-03

167

Results of electron beam therapy using intra-oral cone for carcinoma of the oral tongue  

Energy Technology Data Exchange (ETDEWEB)

Retrospective analyses were performed to evaluate the therapeutic efficacy of intra-oral cone (IOC) radiation therapy for carcinoma of the oral tongue, especially about its faculty of local control and complications. Thirty-nine patients with squamous cell carcinoma of the oral tongue were treated with IOC radiation therapy alone or in combination with external irradiation. IOC radiation therapy was given not only for T1 and T2, but also for T3 tumors. Hypofractionation was used for IOC radiation therapy. The 2 year local control rates, including surgical salvage, for T1, T2, T3 and T4 were 100%, 73.3%, 40% and 0%, respectively. The 5 year actuarial survival rates for Stage I, II, III and IV were 100%, 65.3%, 35.4% and 0%, respectively. The incidences of radiation complications, i.e. soft tissue ulceration and osteoradionecrosis, were 42.9% and 2.9%, respectively. It is suggested that relatively high rate of soft tissue ...

1992-07-01

168

Murine antibody response to oral infection with live aroA recombinant Salmonella dublin vaccine strains expressing filamentous hemagglutinin antigen from Bordetella pertussis.  

Science.gov (United States)

Two plasmids which express either nearly intact or truncated filamentous hemagglutinin (FHA) from Bordetella pertussis and which are marked with a tetracycline resistance (Tcr) gene were transformed into Salmonella dublin SL1438, an aroA deletion mutant intended for use as an attenuated oral vaccine against salmonellosis. These S. dublin recombinants, when fed to mice, induced serum immunoglobulin, immunoglobulin M (IgM), and sometimes IgA antibody responses to FHA and S. dublin. In addition, IgA antibodies against FHA were found in gut wash fluids. S. dublin carrying pDB2300, a multicopy plasmid encoding truncated FHA protein, induced a better antibody response than did S. dublin carrying pDB2000, a low-copy-number plasmid encoding full-sized FHA. Administration of tetracycline to mice enhanced the stability of recombinant plasmids, and tetracycline-treated mice developed higher anti-FHA titers. Although neither strain examined is suitable for use in a human ...

1990-08-01

169

Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive.  

Science.gov (United States)

The effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive containing 30 micrograms ethinyl estradiol and 75 micrograms gestodene were assessed in a randomized, double-blind, placebo-controlled parallel-group study in healthy premenopausal female volunteers established in a regimen of oral contraceptive use. They received either placebo or 2400 mg/day felbamate from midcycle (day 15) to midcycle (day 14) of two consecutive oral contraceptive cycles (months 1 and 2). Pharmacokinetic assessments of ethinyl estradiol and gestodene were performed on day 14 of both cycles. To determine whether ovulation occurred, plasma progesterone and urinary luteinizing hormone levels were measured, and diaries recording vaginal bleeding were kept. Felbamate treatment resulted in a significant 42% decrease in gestodene area under the plasma concentration-time curve (0 to 24 hours) (p = 0.018) compared with ...

1995-11-01

170

Soil Association : Arable  

Wastenet

... Although the rest of the country is less affected, if UK annual feeding and milling volumes of wheat are approximately 120,000t the drought will inevitably result in a shortfall. Looking back at the 2010 season the organic arable market performed strongly, with average feed wheat values since Christmas of 𧷐/tonne - 䀆/t higher then the same period last year. This provided a profitable ...

171

Prolonged exclusive breast feeding and heredity as determinants in infantile atopy.  

UK PubMed Central (United Kingdom)

We followed 183 infants for two years, 31 of whom were breast fed less than three and a half months (median 70 days; short breast feeding group) and a further 31 of whom were exclusively breast fed...Full Text Available

1987-03-01

172

Exploiting the beneficial effects of PPO on the utilisation of protein and lipids in grazed forages  

Environmental Research Database

DescriptionThe plant enzyme polyphenol oxidase (PPO) has been demonstrated to reduce both proteolysis and lipolysis during the ensiling of red clover. The purpose of this work is to explore the potential for exploiting this beneficial trait in other dietary regimes for grazing ruminants. These studies will focus on the development of new strategies for forage management and livestock feeding by increasing the efficiency of feed protein-N utilisation and reducing saturated fatty acid production by ruminan [continued...

2007-01-31

173

Coal liquefaction process  

Energy Technology Data Exchange (ETDEWEB)

A C.sub.5 -900.degree. F. (C.sub.5 -482.degree. C.) liquid yield greater than 50 weight percent MAF feed coal is obtained in a coal liquefaction process wherein a selected combination of higher hydrogen partial pressure, longer slurry residence time and increased recycle ash content of the feed slurry are controlled within defined ranges.

1983-01-01

174

Advanced direct coal liquefaction concepts. Quarterly report, August 1--September 30, 1992  

Energy Technology Data Exchange (ETDEWEB)

The Project was started August 1, 1992. During these first two months, the Project Management plan was issued and approved during discussions at the Pittsburgh Energy and Technology Centre. Feed materials for the experimental work (with the exception of the second solvent) have been received. The analytical work up of these feed materials has been completed, and autoclave stability tests with the solvent and solvent fraction have been performed and analyzed. The Project is proceeding on schedule.

1992-10-26

175

Advanced direct coal liquefaction concepts  

Energy Technology Data Exchange (ETDEWEB)

The Project was started August 1, 1992. During these first two months, the Project Management plan was issued and approved during discussions at the Pittsburgh Energy and Technology Centre. Feed materials for the experimental work (with the exception of the second solvent) have been received. The analytical work up of these feed materials has been completed, and autoclave stability tests with the solvent and solvent fraction have been performed and analyzed. The Project is proceeding on schedule.

1992-10-26

176

MRT of the abdomen in combination with enteroclysis in Crohn disease with oral and intravenous Gd-DTPA  

International Nuclear Information System (INIS)

60 patients between 17 and 72 years of age were investigated. First, an enteroclysis was performed in typical manner. The applicated methylcellulosis was blended with positive oral MR contrast media (Magnevist oral, Schering). After enteroclysis, MRI of the abdomen was performed using T1- and T2-weighted breathhold sequences (Flash 2D pre- and postcontrast and TSE) in axial and coronal planes. The length of the affected bowel and the stenosis seen with enteroclysis correlated well with the visible thickening of the small bowel wall and the stenosis seen in MRI. Using MRI, additional findings could be obtained in 28 patients, such as fistulas, abscesses or a hydronephrosis, or a better assessment of the stenosis was possible with MRI, because of the avoidance of overshadowing of the affected bowel loop with MRI. A brilliant MR-tomographic imaging of the small bowel is possible under the condition, that the small bowel contrast is optimal. The ...

177

Interactions between the chemotherapeutic agent eribulin mesylate (E7389) and P-glycoprotein in CF-1 abcb1a-deficient mice and Caco-2 cells  

British Library Electronic Table of Contents (United Kingdom)

Eribulin is a new anticancer agent currently in Phase III clinical trials for the treatment of metastatic breast cancer. In the current studies, we have investigated the effects of P-glycoprotein (P-gp) on the in vivo disposition of eribulin using CF-1 abcb1a-deficient mice, and the influence of eribulin on P-gp-mediated efflux of digoxin in Caco-2 cells. Eribulin was administered intravenously and orally in both CF-1 wild-type and CF-1 abcb1a-deficient mice. P-gp-mediated efflux of digoxin in Caco-2 cell monolayers was measured in the presence of eribulin. The plasma exposure to eribulin was higher in CF-1 abcb1a-deficient mice than that in CF-1 wild-type mice after intravenous (IV) and oral (PO) administrations. The oral bioavailability of eribulin was 62.3% in CF-1 abcb1a-deficient mice...

2011-01-01

178

Aluminum bioavailability from tea infusion  

British Library Electronic Table of Contents (United Kingdom)

The objective was to estimate oral Al bioavailability from tea infusion in the rat, using the tracer 26Al. 26Al citrate was injected into tea leaves. An infusion was prepared from the dried leaves and given intra-gastrically to rats which received concurrent intravenous 27Al infusion. Oral Al bioavailability (F) was calculated from the area under the 26Al, compared to 27Al, serum concentrationxtime curves. Bioavailability from tea averaged 0.37%; not significantly different from water (F=0.3%), or basic sodium aluminum phosphate (SALP) in cheese (F=0.1-0.3%), but greater than acidic SALP in a biscuit (F=0.1%). Time to maximum serum 26Al concentration was 1.25, 1.5, 8 and 4.8h, respectively. These results of oral Al bioavailabilityxdaily consumption by the human suggest tea can provide a si...

2008-01-01

179

A phase 1 study of BMS-275183, a novel oral analogue of paclitaxel given on a daily schedule to patients with advanced malignancies  

British Library Electronic Table of Contents (United Kingdom)

Summary Purpose BMS-275183 is an oral C-4 methyl carbonate analogue of paclitaxel that has the same mechanism of action, stabilization of tubulin polymerization. The present study was designed to: (i) assess the safety and tolerability of BMS-275183, and (ii) determine a suitable Phase II dose of BMS-275183 when given on a continuous daily schedule to patients with advanced solid tumor(s). Methods This was a multi-institutional, open-label, Phase I, single-arm dose escalation study in which cohorts of eligible patients with advanced malignancies were treated with BMS-275183 orally on a continuous daily schedule. The starting dose level was 6?mg/m2/day administered once daily. Cohorts of 3 patients were treated at each dose level provided no dose-limiting toxicities (DLTs) were observed. Ea...

2011-01-01

180

Short-term oral administration of several manganese compounds in mice: Physiological and behavioral alterations caused by different forms of manganese  

Energy Technology Data Exchange (ETDEWEB)

In Kanazawa, Japan, air pollution from a Mn treatment factory was found to affect local junior high school students, who showed reduced respiratory function relative to their exposure to Mn. The use of Mn as an antiknock ingredient in automobile fuels has recently been introduced, placing the general population at risk of chronic low-level exposure. There are few animal studies on the effects of compounds other than manganese chloride (MnCl{sub 2}). In the case of environmental pollution by Mn, the differing physiological effects of the various chemical forms of Mn must be considered. The present study therefore examined the differences in the effects of several Mn compounds on the physiology and behavior of mice by short-term oral administration.

1991-06-01

181

Physiologically based toxicokinetic modelling as a tool to assess target organ toxicity in route-to-route extrapolation-The case of coumarin  

British Library Electronic Table of Contents (United Kingdom)

Coumarin (1,2-benzopyrone) is occurring in food, and is also used in cosmetics. In order to perform a risk assessment for both oral and dermal exposure, we applied a physiologically based approach to model kinetics in humans by simulating both routes of exposure. The concentration-time profile in liver revealed a higher peak concentration (Cmax-hep) for the oral when compared to the dermal route. The area under the concentration-time curve in the liver (AUChep) was found the same for both routes if the same extent of absorption is assumed. Dose response information from published rat studies were used to identify the metric relevant for liver toxicity. Liver exposure levels resulting from doses and durations as outlined in the studies were simulated in a rat model. We obtained 31 data pair...

2011-01-01

182

Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma  

British Library Electronic Table of Contents (United Kingdom)

Asthma, affecting as many as 400 million individuals worldwide, is one of the most prevalent chronic health condition in the United States. With an increasing number of patients with asthma and the frequent inability of conventional lifestyle modification and therapy to effectively control the problem, nutritional and dietary therapies are being sought. This study was undertaken to investigate the efficacy of the purple passion fruit peel (PFP) extract, a novel mixture of bioflavonoids, on asthma symptoms. Patients with asthma were studied in a 4-week randomized, placebo-controlled, double-blind trial with oral administration of PFP extract (150 mg/d) or placebo pills. The effects of PFP extract were evaluated by assessing the clinical symptoms of asthma and spirometry tests. Most clinical...

2008-01-01

183

Fluoride rinsing and dental health inequalities in 11-year-old children: an evaluation of a supervised school-based fluoride rinsing programme in Edinburgh  

British Library Electronic Table of Contents (United Kingdom)

Levin KA, Jones CM, Wight C, Valentine C, Topping GVA, Naysmith R. Fluoride rinsing and dental health inequalities in 11-year-old children: an evaluation of a supervised school-based fluoride rinsing programme in Edinburgh. Community Dent Oral Epidemiol 2009; 37: 19-26. Copyright 2009 The Authors. Journal compilation Copyright 2009 John Wiley &Sons A/S Abstract - Objectives: Previous studies have shown that fluoride mouthrinsing programmes are effective in reducing caries among children and adolescents. National surveys of child dental health in the UK confirm that there is variation in oral health. In particular, children of low socioeconomic status in Scotland have a disproportionately high share of dental disease. This study aimed to evaluate an existing school-based fluoride mouthrinsi...

2009-01-01

184

Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial  

British Library Electronic Table of Contents (United Kingdom)

Summary Background There is a need for new artemisinin-based combination therapies that are convenient, effective, and safe. We compared the efficacy and safety of pyronaridine-artesunate with that of artemether-lumefantrine for treatment of uncomplicated P falciparum malaria. Methods This phase 3, parallel-group, double-blind, randomised, non-inferiority trial was undertaken in seven sites in Africa and three sites in southeast Asia. In a double-dummy design, patients aged 3-60 years with uncomplicated P falciparum malaria were randomly assigned in a 2:1 ratio to receive pyronaridine-artesunate once a day or artemether-lumefantrine twice a day, orally for 3 days, plus respective placebo. Randomisation was done by computer-generated randomisation sequence in blocks of nine by study centre....

2010-01-01

185

Effect of nonsteroidal anti-inflammatory drug plasters for knee osteoarthritis in Japanese: a randomized controlled trial  

British Library Electronic Table of Contents (United Kingdom)

The objective of this study was to examine the effect of a nonsteroidal anti-inflammatory drug (NSAID) plaster for knee osteoarthritis among Japanese patients. An open-labeled, randomized, controlled, multiclinic trial was performed involving outpatient clinic groups. Two comparative groups?plaster NSAIDs and oral NSAIDs?were randomly allocated. The drugs used were limited to the current top three in both groups in Japan. Treatments were assessed after four?weeks and compared with the baseline scores. Outcomes were evaluated by two psychometric measures: Japanese knee osteoarthritis measure, and pain with the visual analogue scale. The total number of patients included in the final evaluation was 165 (87 for the plaster group and 78 for the oral group). Between these two groups there were ...

2010-01-01

186

Assessment of oral toxicity and safety of 9-cis-UAB30, a potential chemopreventive agent, in rat and dog studies  

British Library Electronic Table of Contents (United Kingdom)

9-cis-UAB30 is a potential chemopreventative agent that has been shown to be effective on many different types of tumors. The safety and toxicity of 9-cis-UAB30 had not been previously established. These studies were conducted to evaluate the potential toxicity and pharmacokinetics in a rodent and a nonrodent species for the purpose of investigational new drug submission. Oral gavage administration of 9-cis-UAB30 at the doses 0, 3, 15, and 100 ?mg/kg/day to CD? rats for 28 days showed a dose-dependent (although not dose-proportional) increase in plasma drug levels in week 4. The liver was the target organ for toxicity of 9-cis-UAB30. Hepatomegaly along with increases in serum aspartate-aminotransferase and alkaline-phosphatase levels were seen in rats. Moderate hypoalbuminemia and hyperglo...

2011-01-01

187

Application of microvascular free osteocutaneous flaps in the management of post-radiation recurrent oral cancer  

Energy Technology Data Exchange (ETDEWEB)

Fifty-nine patients underwent free flap osteocutaneous reconstruction that consisted of flaps of the dorsum of the foot in 26 patients and iliac crest flaps in 33 with a success rate of 92 percent and a mortality rate of 1.6 percent. These flaps, which require the expertise of microvascular surgeons, are time-consuming and complicate operating room and time management, but they represent a remarkable advance in reconstruction that can facilitate cosmetic and functional recovery of the patient. In particular, they promote healing in radiation-recurrent oral cancer and represent a definitive form of management for established radionecrosis of the mandible. The large volume of tissue available with iliac crest osteocutaneous grafts permits the management of patients with extensive cancer involving the skin, mucosa, and bone, but cancer control may still be disappointing and there is a need for improved adjuvant chemotherapy protocols. This technique appears to be a ...

1985-10-01

188

The adenovirus-2 EIIa early gene promoter: sequences required for efficient in vitro and in vivo transcription.  

UK PubMed Central (United Kingdom)

A series of deletion mutants extending from -250 toward the capsite has been constructed in the early promoter region of the adenovirus 2 EIIa gene and tested both in vitro, and in vivo after transfection...Full Text Available

1983-10-25

189

Sunbed use during adolescence and early adulthood is associated with increased risk of early-onset melanoma  

UK PubMed Central (United Kingdom)

Sunbed use is associated with increased risk of melanoma. Younger people might be more susceptible to the carcinogenic effects of ultraviolet radiation. We investigated the association between...Full Text Available

2011-05-01

190

Stage-specific protein synthesis during early embryogenesis in Drosophila melanogaster.  

UK PubMed Central (United Kingdom)

The changes in protein species synthesized during early Drosophila embryogenesis were characterized by two-dimensional electrophoresis. Of the 261 proteins scored, 68 (26%) show dramatic changes in...Full Text Available

1983-01-01

191

Sequential Molecular and Cellular Events during Neoplastic Progression: A Mouse Syngeneic Ovarian Cancer Model1  

UK PubMed Central (United Kingdom)

AbstractStudies performed to identify early events of ovarian cancer and to establish molecular markers to support early detection and development of chemopreventive regimens have been...Full Text Available

2005-10-01

192

Prevalence of Early and Late Age-Related Macular Degeneration in India: The INDEYE Study  

UK PubMed Central (United Kingdom)

Purpose.To estimate the prevalence of early and late age-related macular degeneration (AMD) in India.Methods.Of 7518 people aged 60 years and older...Full Text Available

2010-02-01

193

One-Year Durability of the Effects of Cognitive Enhancement Therapy on Functional Outcome in Early Schizophrenia  

UK PubMed Central (United Kingdom)

Cognitive rehabilitation is an effective intervention for addressing cognitive impairments in patients with schizophrenia. Previous research has shown that the early application of Cognitive...Full Text Available

2010-07-01

194

Muscularis mucosae in desmoplastic stroma formation of early invasive rectal adenocarcinoma  

UK PubMed Central (United Kingdom)

The origin of myofibroblasts or myofibroblastic cells in the desmoplastic stroma associated with carcinoma invasion has been controversial. In the early invasive area of a rectal adenocarcinoma reported...Full Text Available

2009-10-21

195

Multiparameter Phospho-Flow Analysis of Lymphocytes in Early Rheumatoid Arthritis: Implications for Diagnosis and Monitoring Drug Therapy  

UK PubMed Central (United Kingdom)

BackgroundThe precise mechanisms involved in the initiation and progression of rheumatoid arthritis (RA) are not known. Early stages of RA often have non-specific symptoms, delaying...Full Text Available

196

Monitoring of Tumor Promotion and Progression in a Mouse Model of Inflammation-Induced Colon Cancer with Magnetic Resonance Colonography1  

UK PubMed Central (United Kingdom)

Early detection of precancerous tissue has significantly improved survival of most cancers including colorectal cancer (CRC). Animal models designed to study the early stages of cancer are valuable...Full Text Available

2009-03-01

197

Metal stenting to resolve post-photodynamic therapy stricture in early esophageal cancer  

UK PubMed Central (United Kingdom)

Photodynamic therapy (PDT) is an established endoscopic technique for ablating Barrett’s esophagus with high-grade dysplasia or early-stage intraepithelial neoplasia. The most common clinically...Full Text Available

2011-03-14

198

Inheritable Effect of Unpredictable Maternal Separation on Behavioral Responses in Mice  

UK PubMed Central (United Kingdom)

The long-term impact of early stress on behavior and emotions is well documented in humans, and can be modeled in experimental animals. In mice, maternal separation during early postnatal development...Full Text Available

199

Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses  

UK PubMed Central (United Kingdom)

SUMMARYDendritic cells (DCs) in mucosal surfaces are early targets for human immunodeficiency virus-1 (HIV-1). DCs mount rapid and robust immune responses upon pathogen encounter....Full Text Available

2010-05-28

200

Early auditory experience generates long-lasting memories that may subserve vocal learning in songbirds  

UK PubMed Central (United Kingdom)

In both humans and songbirds, infants learn vocalizations by imitating the sounds of adult tutors with whom they interact during an early sensitive period. Vocal learning occurs in few animal taxa;...Full Text Available

2006-01-24

201

Early Wound Healing Following One-Stage Dental Implant Placement With and Without Antibiotic Prophylaxis: A Pilot Study  

UK PubMed Central (United Kingdom)

BackgroundOne-stage implant placement has clinically acceptable treatment outcomes. Among other advantages, it may allow investigation of early wound healing. The...Full Text Available

2008-10-01

202

EARLY FLOWERING3 Encodes a Novel Protein That Regulates Circadian Clock Function and Flowering in Arabidopsis  

UK PubMed Central (United Kingdom)

Higher plants use photoperiodic cues to regulate many aspects of development, including the transition from vegetative to floral development. The EARLY FLOWERING3 (ELF3)...Full Text Available

2001-06-01

203

Cross sectional early mitral flow velocity profiles from colour Doppler.  

UK PubMed Central (United Kingdom)

Instantaneous cross sectional flow velocity profiles from early mitral flow in 10 healthy men were constructed by time interpolation of the velocity data from each point in sequentially delayed two...Full Text Available

1989-09-01

204

Characterization of the 5'-terminal cap structures of early simian virus 40 mRNA.  

UK PubMed Central (United Kingdom)

Early simian virus 40-specific mRNA was isolated from lytically infected and stably transformed cells and analyzed with respect to the 5'-terminal cap content. An analogous diversity of capped structures...Full Text Available

1980-09-01

205

SPACE FLIGHT 1999 - NASA  

Science.gov (United States)

Mission losses were incurred by an early warning satellite and a Milstar-2 communications satellite when their launch vehicles malfunctioned, the first, ...

208

Early axial spondyloarthritis  

UK PubMed Central (United Kingdom)

Purpose of reviewTo summarize recent advances in the classification of preradiographic axial spondyloarthritis (SpA).Recent findingsFull Text Available

2010-09-01

209

Early Season Applications of Fluridone for Control of Curlyleaf ...  

Science.gov (United States)

... While the large tanks served to regulate the water temper- ature, the polypropylene aquaria served as independent experimental units. ...

2010-12-01

210

Early Life Crises of Habitable Planets  

ScienceCinema

...global warming such such a pressing ...global warming and actually for all climate change problems that ...for the global warming problem ...

211

Demonstration of Synchronization Between Two ...  

Science.gov (United States)

... Abstract in early 1996 Milstar became the first geosynchronous satellife system to employ crosslinks for synchronization and syntoniulfion. ...

1996-12-01

213

A Study of the Geographic Origin, Education, and Experience ...  

Science.gov (United States)

... by starting and remaining in that size hotel. Another early study, conducted by Nailon (1968) sampled three general managers ...

1993-04-01

214

Short-term toxicological evaluation of Terminalia catappa, Pentaclethra macrophylla and Calophyllum inophyllum seed oils in rats  

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study was to evaluate the toxicological effects of feeding the oils of Calophyllum inophyllum, Pentaclethra macrophylla and Terminalia catappa to rats. The effects on physical appearance, feed intake, weight gain, plasma and tissue cholesterol and triacyglycerol levels in rats with 5% of the oils in normal rat feed were determined. Weekly monitoring of the rats showed good physical appearance and steady weight gain, with no mortality recorded for the period of the study. Haematological analysis of the rats indicated that they were not anaemic. Histopathotogical examination of the sections of the heart, liver, kidney and spleen revealed moderate (T. catappa oil) to severe fatty change and necrosis in the liver. Glomerulonephrotic changes in the kidneys of rats fed with T...

2008-01-01

215

Mulled coal: A beneficiated coal form for use as a fuel or fuel intermediate  

Energy Technology Data Exchange (ETDEWEB)

Energy International is developing a technology that will create a staged formulation with the first coal form (Mulled Coal) that can be stored, transported, and pumped. Just prior to combustion, the Mulled Coal (MC) would be modified to provide the properties needed for proper atomization. This concept is an alternative to the expensive and energy intensive thermal drying processing of fine coal wet cakes. The material is suitable for both direct feed use in conventional and fluid bed combustors as well as on-site conversion to combustible slurries. By maintaining the coal form relatively close to the feed wet cake, only minor processing with low additive levels and low energy blending needed at the point of production. Its conversion to slurry or other use-feed form is made near the time of use and thus the requirements for stability, climatic control, and other storage, transport, and handling requirements are much less ...

1991-10-01

216

Method of feeding a coolant into a reactor  

International Nuclear Information System (INIS)

Object: To suppress a quantity of impurities in a coolant fed into a reactor vessel. Structure: The concentration of oxygen in a coolant flowing from a condensation desalting instrument into a feed and condensation piping is measured by an oxygen-concentration detector to feed its signal to an adjusting instrument. A degree of opening of an oxygen flow control valve to maintain the concentration of oxygen in the cooling water flowing within the pipe in the range from about 10 to about 200 ppb. Also, the concentration of oxygen in the cooling water fed to the desalting instrument is maintained at a level less than 2 ppb. Thereby, the total amount of iron flown into the vessel can be suppressed to a fine amount such as less than about 1 ppb. (Kawakami, Y.).

217

Manufacturing of Austenitic Stainless Steel-Zirconia Composites by Infiltration  

British Library Electronic Table of Contents (United Kingdom)

Abstract Within the framework of the CRC 799 -TRIP-Matrix-Composites- at the TU Bergakademie Freiberg new composite materials consisting of TRIP steel and zirconium dioxide ceramics are designed in a powder route and a casting route. To manufacture faultless samples basic investigations of the feeding and infiltration behaviour within macro porous ceramics such as filters were needed. The effects of bottom pouring and top pouring were investigated as well as the effects of different preheating temperatures, contents of phosphorous in the steel and flow trough rates. Bottom pouring corrupts the feeding mainly of filters with high ppi (pores per inch). Top pouring improves the feeding, but generates inhomogeneous infiltration qualities, which can affected and enhanced by a increasing preheat...

2011-01-01

218

Feedwater control device for a reactor  

International Nuclear Information System (INIS)

Purpose: To stably control the reactor water level so as not to cause excess water feeding in a BWR type reactor. Constitution: A flow control valve is disposed to the exit of a feedwater pump for a nuclear reactor and the valve is controlled by a flow regulator to maintain the water level constant in the reactor. A signal from a water level controller is inputted to the flow regulator to thereby control the flow rate control valve. In this case, the flow regulator remains in a saturated state just after the starting of the feedwater pump, in which the pump flowrate is at 100% to result in an excess water feeding condition. In view of the above, a feedback circuit is provided to the flow regulator so that the saturated state is eliminated and the water feeding can be controlled directly from the water level controller. (Kamimura, M.).

1981-11-12

219

Failure analyses and weld repair of boiler feed water pumps  

Energy Technology Data Exchange (ETDEWEB)

During a regular inspection of the Boiler Auxiliaries at one of the Dutch Electricity Production Companies serious cracks were found in the cover and casings of the feed water circulation pumps in two units after 108.000 and 122.000 hours of boiler operation. Kema Laboratories carried out Failure analyses on boat samples at the cracked areas. Corrosion fatigue cracking was found on the inner side of the GS-24CrNiMo325 casing. Shop Weld repairs were carried out using a newly developed mechanized Plasma Welding Technique. The repaired feed water circulation pumps showed no problems alter several years of operation. The costs of repair were substantially lower than the costs of replacement. (orig.) 3 refs.

1998-12-31

220

Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule  

British Library Electronic Table of Contents (United Kingdom)

Excessive physical activity plays an important role in the progression of anorexia nervosa (AN) by accelerating weight loss during dietary restriction. To search for mechanisms underlying this trait, a panel of mouse chromosome substitution strains derived from C57BL/6J and A/J strains was exposed to a scheduled feeding paradigm and to voluntary running wheel (RW) access. Here, we showed that A/J chromosomes 4, 12 and 13 contribute to the development of a disrupted RW activity in response to daily restricted feeding. This pattern is characterized by intense RW activity during the habitual rest phase and leads to accelerated body weight loss. Regions on mouse chromosomes 4, 12 and 13 display homology with regions on human chromosomes linked with anxiety and obsessionality in AN cohorts. The...

2010-01-01

221

The morphologic effects of synthetic reproductive steroids on the mammary gland of rhesus monkeys. Mestranol, ethynerone, mestranol-ethynerone, chloroethynyl norgestrel-mestranol, and anagestone acetate-mestranol combinations.  

UK PubMed Central (United Kingdom)

A total of 213 treated and 16 control monkeys comprising 12 experimental groups was evaluated for determination of the long-term (10 years) effects of various dosages of a variety of synthetic oral...Full Text Available

1988-05-01

222

Tamsulosin oral controlled absorption system (OCAS) in the treatment of benign prostatic hypertrophy  

UK PubMed Central (United Kingdom)

The efficacy of tamsulosin at the cost of a relatively benign side effect profile has been attributed to receptor selectivity directed at the α1a and α1d adrenergic...Full Text Available

2008-02-01

223

Table of Contents  

British Library Electronic Table of Contents (United Kingdom)

Abstract Clonidine Extended Release Augmentation of Psychostimulants in ADHD ADHD a Risk Factor for Substance Abuse; Cognitive Deficits Not a Predictor Commentary on Kollins et al.; Clonidine XR Augmentation for ADHD Pharmacologic Treatment of Childhood Insomnias Effects of Guanfacine Extended Release on Alertness in ADHD Long Term ADHD Drug Treatment Bipolar Disorder Rates Similar Across Selected Countries Group CBT Alone or Group CBT Plus SSRIs in Childhood Anxiety Resolution of Quetiapine-Induced Oral Dyskinesia From the FDA

2011-01-01

224

Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitors  

British Library Electronic Table of Contents (United Kingdom)

A novel class of pyrrolidinyl-acetyleneic thieno[3,2-d]pyrimidines has been identified which potently inhibit the EGFR and ErbB-2 receptor tyrosine kinases. Synthetic modifications of the pyrrolidine carbamate moiety result in a range of effects on enzyme and cellular potency. In addition, the impact of the absolute stereochemical configuration on cellular potency and oral mouse pharmacokinetics is described.

2009-01-01

225

Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation  

UK PubMed Central (United Kingdom)

Matrix metalloproteinase (MMP) plays a crucial role in periodontal disease and is up-regulated by oral Gram-negative, pathogen-derived LPS. In this study, we reported that simvastatin, a 3-hydroxyl-3-methylglutaryl-CoA...Full Text Available

2008-10-01

226

Serum and salivary responses to oral tetravalent reassortant rotavirus vaccine in newborns.  

UK PubMed Central (United Kingdom)

Serum and salivary responses of 95 infants to either a standard (4 x 10(4) plaque-forming units (PFU), 47 neonates) or a high dose (4 x 10(5) PFU, 48 neonates) of tetravalent reassortant rhesus rotavirus...Full Text Available

1993-05-01

227

Lee Oral History, January 16, 2008 - Johnson Space Center  

Science.gov (United States)

Jan 16, 2008 ... home town, and awards, as well as the ground personnel. .... I was also awarded six air medals, which were given based on the number of missions ..... We took these projects from birth to grave. .... Japanese sonar on their submarine. About that time another airplane dropped a bomb ...

228

Invasiveness and persistence of Salmonella enteritidis, Salmonella typhimurium, and a genetically defined S. enteritidis aroA strain in young chickens.  

UK PubMed Central (United Kingdom)

Newly hatched chicks were dosed orally with a Salmonella typhimurium wild-type strain, an S. enteritidis wild-type strain, and a genetically defined S. enteritidis aroA vaccine candidate, strain CVL30....Full Text Available

1994-11-01

229

Efficacy of the Carbocyclic 2?-Deoxyguanosine Nucleoside BMS-200475 in the Woodchuck Model of Hepatitis B Virus Infection  

UK PubMed Central (United Kingdom)

Daily oral treatment with the cyclopentyl 2′-deoxyguanosine nucleoside BMS-200475 at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduced the level of woodchuck...Full Text Available

1998-12-01

230

Effects of graded oral doses of a new 5-hydroxytryptamine/noradrenaline uptake inhibitor (Ro 15-8081) in comparison with 60 mg codeine and placebo on experimentally induced pain and side effect profile in healthy men.  

UK PubMed Central (United Kingdom)

1. Ro 15-8081 (Hoffmann-La Roche, Basle, Switzerland) is a novel mixed 5-HT/noradrenaline uptake inhibitor producing potent antinociceptive effects in animal pain models. 2. In healthy man, two models...Full Text Available

1987-11-01

231

Assessment of Oral Toxicity and Safety of Pentamethylchromanol (PMCol), A Potential Chemopreventative Agent, in Rats and Dogs  

UK PubMed Central (United Kingdom)

2,2,5,7,8-pentamethyl-6-chromanol (PMCol) was administered by gavage in rats for 28 days at dose levels of 0, 100, 500, and 2000 mg/kg/day. PMCol administration induced decreases in body weight...Full Text Available

2010-06-29

232

A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.  

Science.gov (United States)

The transcriptional silencing of some cell cycle inhibitors and tumor suppressors, such as p16 and retinoic acid receptor beta(2), by DNA hypermethylation at CpG islands is commonly found in human oral squamous carcinoma cells. We examined the effects of the DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-Aza; 0.25 mg/kg body weight), all-trans retinoic acid (RA; given at 100 microg/kg body weight and 1 mg/kg body weight), and the combination of 5-Aza and the low-dose RA on murine oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in a mouse model. All the drug treatments were done for 15 weeks after a 10-week 4-NQO treatment. Mice in all drug treatment groups showed decreases in the average numbers of neoplastic tongue lesions. The combination of 5-Aza and RA effectively attenuated tongue lesion severity. Although all drug treatments limited the increase in the percentage of proliferating cell ...

2009-12-01

233

28-Day Toxicity Study of 1-Methylethyl 2-Chloro-5-(((1-Methylethoxy)Thiomethyl)Amino)Benzoate (NSC-D629243) in Hamsters.  

Science.gov (United States)

The study was conducted to determine potential target organ toxicity and its reversibility in hamsters following twice daily oral doses of NSC-D629243 for 28 consecutive days. Male and female hamsters were administered NSC-D629243 dissolved in sesame oil ...

1992-01-01

234

Transmission of Salmonella mbandaka to cattle from contaminated feed.  

UK PubMed Central (United Kingdom)

Salmonella mbandaka was isolated from cattle on three dairy farms. The duration of infection was less than four weeks and none of the animals became clinically ill. The animals had all consumed a diet...Full Text Available

1982-04-01

235

Study on upgrading of oil palm wastes to animal feeds by radiation and fermentation processing  

International Nuclear Information System (INIS)

Upgrading of oil palm empty fruit bunch (EFB), which is a main by-product of palm oil industry, to animal feeds by radiation pasteurization and fermentation was investigated for recycling the agro-resources and reducing the environmental pollution. The following results were obtained: 1) The necessary dose for pasteurization of EFB contaminated by various microorganisms including aflatoxin producing fungi was determined as 10 kGy. The chemical and biological properties of EFB were changed little by irradiation up to 50 kGy. 2) In the fermentation process, Pleurotus sajor-caju was selected as the most effective fungi and the optimum condition for fermentation was clarified. The process of fermentation in suspension was also established for the liquid seed preparation. 3) The digestibility and nutritional value of fermented products were evaluated as ruminant animal feeds and the mushroom can be produced as by-product. 4) The pilot plant named ...

2002-10-15

236

Stable isotopes document the trophic structure of a deep-sea cephalopod assemblage including giant octopod and giant squid  

UK PubMed Central (United Kingdom)

Although deep-sea cephalopods are key marine organims, their feeding ecology remains essentially unknown. Here, we report for the first time the trophic structure of an assemblage of these animals (19...Full Text Available

2009-06-23

237

Safety of pull-type and introducer percutaneous endoscopic gastrostomy tubes in oncology patients: a retrospective analysis  

UK PubMed Central (United Kingdom)

BackgroundPercutaneous endoscopic gastrostomy (PEG) allows long-term tube feeding. Safety of pull-type and introducer PEG placement in oncology patients with head/neck or oesophageal...Full Text Available

238

Relations between respiratory symptoms and sickness among workers in the animal feed industry.  

UK PubMed Central (United Kingdom)

OBJECTIVE--The survey aimed at studying the associations between prevalent respiratory symptoms in an occupational population and sickness absence due to respiratory disorders. METHODS--A cross sectional...Full Text Available

1994-07-01

239

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.  

UK PubMed Central (United Kingdom)

The effects of homologous plasma HDL and VHDL fractions on established atherosclerotic lesions were studied in cholesterol-fed rabbits. Atherosclerosis was induced by feeding the animals a 0.5% cholesterol-rich...Full Text Available

1990-04-01

240

Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons  

UK PubMed Central (United Kingdom)

Some pathological conditions with feeding pattern alterations, including obesity and Huntington disease (HD) are associated with hypothalamic dysfunction and neuronal cell death. Additionally, the hypothalamus...Full Text Available

241

Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (NPY) gene  

UK PubMed Central (United Kingdom)

BackgroundNeuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and...Full Text Available

242

Kneading of stearic acid into an extruder  

Energy Technology Data Exchange (ETDEWEB)

An extruder used by kneading stearic acid (St acid) into it for the production of polystyrene for injection molding was studied. Most disadvantageous of kneading methods, melt-feed method, was applied because this method enables the utilization of existing facilities. St acid is discolored when the temperature surpasses 270{sup 0}C in nitrogen atmosphere, and the contact with metals intensifies the discoloring. The discoloring is more intensified by the contact with nitriding steel than with stainless steel. Residence time is 85 seconds, and even the contact with nitriding steel does not discolor ST acid when the temperature is lower than 270{sup 0}C. In the melt-feed method, when the die is in a bad shape, it brings about dead space at the tip of the die and St acid holds up there. When the kneading is in bad condition (St acid and polymer are hard to mix because their viscosities are quite different), St acid gathers between the barrel wall ...

1989-09-01

243

In vitro digestibility of fern and gymnosperm foliage: implications for sauropod feeding ecology and diet selection  

UK PubMed Central (United Kingdom)

Sauropod dinosaurs, the dominant herbivores throughout the Jurassic, challenge general rules of large vertebrate herbivory. With body weights surpassing those of any other megaherbivore, they relied...Full Text Available

2008-05-07

244

Impaired immunity in harbour seals (Phoca vitulina) exposed to bioaccumulated environmental contaminants: review of a long-term feeding study.  

UK PubMed Central (United Kingdom)

Mass mortalities among seals and dolphins inhabiting contaminated marine regions have led to speculation about a possible involvement of immunosuppression associated with environmental pollution. To...Full Text Available

1996-08-01

245

Host plant shifts affect a major defense enzyme in Chrysomela lapponica  

UK PubMed Central (United Kingdom)

Chrysomelid leaf beetles use chemical defenses to overcome predatory attack and microbial infestation. Larvae of Chrysomela lapponica that feed on willow sequester plant-derived salicin...Full Text Available

2011-03-22

246

Fermented empty fruit bunch (FEFB) as feed for ruminant animal  

International Nuclear Information System (INIS)

Fermented oil palm empty fruit bunch, now known as 'Sterifeed' has been characterized by physico-chemical properties. It has also been proven to have an improved digestibility (by in vitro and in-vivo test) over the original material. The remaining important aspect of feed to be examined is the long term effect of feeding this material to animals. The size of fermentation media bags used was 0.5 - 1 kg/bag. In the large scale production of these materials, the numbers of bags were increased. The production at pilot scale level reinvestigated the basic processing parameters for the 1 kg/bag media and also performed a trial run for different sizes of bags. These include: 1) investigation on the growth of fungi on fermentation media subjected to different treatment times and the non treated media, 2) evaluation of the processing rate, 3) trial run processing of 25-50 MT oil palm EFB into feed, and 4) processing of different ...

1998-01-01

247

Evaluation of energy-conservation technologies for the citrus-processing industry  

Energy Technology Data Exchange (ETDEWEB)

The following manual chapters are outlined and described: overview, boilers, juice evaporators, feed mills, refrigeration, additional energy savings potentials, emerging technologies, optimization of integrated plant energy systems, and economics. (MHR)

1980-01-01

248

Effect of Feeding Cows Genetically Modified Maize on the Bacterial Community in the Bovine Rumen?  

UK PubMed Central (United Kingdom)

Rumen-cannulated cows (n = 4) were fed successively silage made from either conventional or genetically modified (GM) maize. Results revealed no effects of GM maize on the dynamics...Full Text Available

2007-12-01

249

Does hypothalamic SIRT1 regulate aging?  

UK PubMed Central (United Kingdom)

In virtually all organisms, life expectancy is profoundly affected by caloric intake. For example, dietary restriction (DR; a feeding regimen of fewer calories compared to the ad libitum level without...Full Text Available

250

Diversity and activity of sugar transporters in nematode-induced root syncytia  

UK PubMed Central (United Kingdom)

The plant-parasitic nematode Heterodera schachtii stimulates plant root cells to form syncytial feeding structures which synthesize all nutrients required for successful nematode development....Full Text Available

2009-07-01

251

Closing the loop In Practice to Assure the Desired Performance  

UK PubMed Central (United Kingdom)

A closed loop control process assures that a system performs within control limits. In closed loop control, the system's output feeds back directly to change the system's inputs. We describe an approach...Full Text Available

2008-01-01

252

Characterization of the stimulatory effect of high-fat diets on peroxisomal beta-oxidation in rat liver.  

UK PubMed Central (United Kingdom)

1. The effect on rat liver peroxisomal beta-oxidation of feeding diets containing various amounts of dietary oils was investigated. With increasing amounts (5-25%, w/w) of soya-bean oil an apparent,...Full Text Available

1982-08-15

253

Canadian infants' nutrient intakes from complementary foods during the first year of life  

UK PubMed Central (United Kingdom)

BackgroundComplementary feeding is currently recommended after six months of age, when the nutrients in breast milk alone are no longer adequate to support growth. Few studies have...Full Text Available

254

CHRONIC ETHANOL FEEDING AFFECTS PROTEASOME INTERACTING PROTEINS  

UK PubMed Central (United Kingdom)

Studies on alcoholic liver injury mechanisms show a significant inhibition of the proteasome activity. To investigate this phenomenon, we isolated proteasome complexes from the liver of rats...Full Text Available

2009-07-01

255

Association of mineral composition of neonatal intravenous feeding solutions and metabolic bone disease of prematurity.  

UK PubMed Central (United Kingdom)

To assess the effects of increasing the mineral content of parenteral nutrition solutions on the biochemical and radiological indicators of metabolic bone disease of prematurity 27 neonates who required...Full Text Available

1989-04-01

256

Allergy and Sensitization during Childhood Associated with Prenatal and Lactational Exposure to Marine Pollutants  

UK PubMed Central (United Kingdom)

BackgroundBreast-feeding may affect the risk of developing allergy during childhood and may also cause exposure to immunotoxicants, such as polychlorinated biphenyls (PCBs), which...Full Text Available

2010-10-01

257

A Curated Database of miRNA Mediated Feed-Forward Loops Involving MYC as Master Regulator  

UK PubMed Central (United Kingdom)

BackgroundThe MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation...Full Text Available

258

Efficacy and safety of total dose infusion of low molecular weight iron dextran in the treatment of iron deficiency anemia during pregnancy  

International Nuclear Information System (INIS)

To determine the efficacy and safety of Total Dose Infusion (TDI) of low molecular weight iron dextran for the treatment of iron deficiency anemia compared to oral iron replacement during pregnancy through improvement in hemoglobin (Hb) after intervention. Non-randomized control trial. A group of 100 pregnant women with gestational age greater than 12 weeks with confirmed diagnosis of iron deficiency anemia attending the antenatal clinics were enrolled in this study. Total dose iron infusion of low molecular iron dextran was given to these patients after calculating iron deficit, in a monitored in-patient setting. Control comprised of a second group of 50 pregnant females matched for age, parity and baseline hemoglobin, tolerant to oral iron supplementation (ferrous sulphate 200 mg three times a day) attending the antenatal clinics during the same period. Post-treatment hemoglobin levels of study group as well as the oral ...

2008-07-01

259

Early Language Learning and Literacy: Neuroscience Implications for Education  

British Library Electronic Table of Contents (United Kingdom)

The last decade has produced an explosion in neuroscience research examining young children's early processing of language that has implications for education. Noninvasive, safe functional brain measurements have now been proven feasible for use with children starting at birth. In the arena of language, the neural signatures of learning can be documented at a remarkably early point in development, and these early measures predict performance in children's language and pre-reading abilities in the second, third, and fifth year of life, a finding with theoretical and educational import. There is evidence that children's early mastery of language requires learning in a social context, and this finding also has important implications for education. Evidence relating socioeconomic status (SES) ...

2011-01-01

260

Effect on the reproductive functions of female rhesus monkeys of feeding irradiated wheat flour and potato diet  

International Nuclear Information System (INIS)

The effects on reproductive functions of feeding adult rhesus monkeys on a diet of irradiated wheat flour and potato was investigated. Wheat flour and potatoes were exposed to 75 000 and 10 000 rad, respectively, of #gamma#-irradiation and then fed to the animals. Various parameters of reproductive function were compared with those of animals fed on unirradiated food. These were: external changes in the reproductive organs, menstrual cycle, vaginal cytology, assay of urinary hormones (oestrogens and pregnanediol), and post-mortem histopathological examination of the reproductive organs. At the end of 3 months, the experimental and control animals behaved similarly with regard to their reproductive functions. (author).

261

Affinity dialysis - a method of continuous, rapid metal ion separation using dialysis membranes and selective, water-soluble polymers as extractants  

Energy Technology Data Exchange (ETDEWEB)

A membrane process utilizing dialysis and selective complexation by water-soluble polymers has been developed. This process, termed affinity dialysis, has been shown to be selectively extract and concentrate both cations and anions in a manner similar to ion exchange or solvent extraction. The selective removal of calcium from sodium with selectivity of about 30, removal of chromate ion from dilute streams, and separation of transition metal ions such as Cu/Fe and Cu/Zn have all been successfully demonstrated. Effects of different polymers, polymer concentration, temperature, and flow rates have been studied. The effect of increased polymer concentration is to increase product concentration if appropriate changes in feed, polymer solution, and strip flow rates are made. A continuous polymer solution recycle and regeneration system has been constructed and operated with Cu/Zn and chromate/chloride feed streams. Removal of over 95% of the desired ...

1988-08-01

262

Preclinical evidence for the benefits of penile rehabilitation therapy following nerve-sparing radical prostatectomy.  

Science.gov (United States)

Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques. This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which result in additional veno-occlusive dysfunction. Recently, daily use of intracavernous vasoactive substances and oral use of PDE5-inhibitors have been clinically studied for treatment of postprostatectomy erectile dysfunction. Since these studies showed benefits of "penile rehabilitation therapy," these effects have been studied in a preclinical setting. We reviewed experimental literature on erectile tissue preserving and neuroregenerative treatment strategies, and found that preservation of the erectile tissue by the use of intracavernous nitric oxide donors or vasoactive substances, oral PDE5-inhibitors, and hyperbaric oxygen therapy improved erectile function by antifibrotic effects and preservation of ...

2008-01-01

263

Pharmacokinetics of buspirone as determined by ex vivo (/sup 3/H)-DPAT binding  

Energy Technology Data Exchange (ETDEWEB)

Ex vivo (/sup 3/H)-8-hydroxy-2-(di-n-propylamino)-tetraline ((/sup 3/H)-DPAT) binding to the hippocampus has been utilized to determine the pharmacokinetic parameters of buspirone after i.v. and oral administration of this drug to rats. Intravenous buspirone rapidly penetrated the brain as demonstrated by a maximum inhibition of (/sup 3/H)-DPAT binding at 1 min. Elimination of drug from the brain was biphasic, with a first component half-life of 24.8 min and a second component half-life of 96 min. Oral buspirone at 3 times the i.v. dose produced less than one-third the maximum inhibition of (/sup 3/H)-DPAT binding compared to that observed with i.v. buspirone. The pharmacokinetic parameters of buspirone observed in the present study are in agreement with those reported previously. Thus, the ex vivo binding assay could be utilized to determine the bioavailability of the drug to the brain, and its duration of action. 20 references, 2 figures, 5 ...

1988-01-01

264

Peru-15, an improved live attenuated oral vaccine candidate for Vibrio cholerae O1.  

Science.gov (United States)

Cholera vaccine candidate Peru-15 was derived from a Vibrio cholerae O1 El Tor Inaba strain by deleting the cholera toxin genetic element, introducing the gene encoding cholera toxin B subunit into recA, and screening for nonmotility. In a controlled study, Peru-15 (2 x 10(8) cfu) was administered to 11 volunteers. No vaccinee developed diarrhea, and 10 of 11 had > 4-fold rises in vibriocidal antibody titers. One month later, 5 vaccinees and 5 control volunteers were challenged with wild type V. cholerae O1. Four of 5 controls developed diarrhea (mean, 1.9 L). Two Peru-15 vaccinees developed diarrhea, 1 with < 0.3 L and 1 with approximately 1.0 L; this latter volunteer had not developed a significant vibriocidal immune response to vaccination. Peru-15 shows promise as a single-dose, oral cholera vaccine that is safe, immunogenic, and protective. PMID:7561195

1995-10-01

265

One-year follow-up of the effects of sildenafil on pulmonary arterial hypertension and veno-occlusive disease  

Scientific Electronic Library Online (English)

Abstract in english We hypothesized that chronic oral administration of the phosphodiesterase-5 inhibitor sildenafil could improve the exercise capacity and pulmonary hemodynamics in patients with pulmonary arterial hypertension (PAH) on the basis of previous short-term studies. We tested this hypothesis in 14 subjects with PAH, including seven patients with the idiopathic form and seven patients with atrial septal defects, but no other congenital heart abnormalities. Patients were subjected (more) to a 6-min walk test and dyspnea was graded according to the Borg scale. Pulmonary flow and pressures were measured by Doppler echocardiography. Patients were given sildenafil, 75 mg orally three times a day, and followed up for 1 year. Sildenafil therapy resulted in the following changes: increase in the 6-min walk distance from a median value of 387 m (range 0 to 484 m) to 462 m (range 408 to 588 m; P

2005-02-01

266

Modern imaging methods for diagnostic evaluation of tumors of the oropharynx and the oral cavity  

International Nuclear Information System (INIS)

Differentiating a benign from a malignant lesion by information such as density data, or signal intensities or echo gradients, is not possible with CT, nor MRI, nor ultrasonography. Only some lesions show characteristic signs. Inflammations cannot be difscriminated from malignant tumors. CTs of small tumors in particular are so poor in contrast that it is much more difficult to detect tumors or discriminate them from other lesions, as compared to MR images or ultrasonographs. CT does not detect surface tumors, but is more sensitive than MRI or US in detecting discrete cortical bone lesions. The same applies to small calcified tumors. MRI however is most sensitive in detecting tumor volumes in the yellow marrow, and is the best modality for evaluation of extraossal extension of tumors. CT yields better results than MRI if applied for simultaneous screening of lymph node metastases in the lower neck. MRI frequently is spoilt by movement artefacts. High-resolution, contrast enhanced CT ...

267

Influence of 2,3-dimercaptosuccinic acid on gastrointestinal lead absorption and whole-body lead retention  

International Nuclear Information System (INIS)

2,3-Dimercaptosuccinic acid (DMSA) is a new orally active heavy metal chelator for the treatment of childhood Pb intoxication on an outpatient basis. The influence of DMSA, as well as other chelating agents, on gastrointestinal 203Pb absorption and whole-body "2"0"3Pb retention was examined. Groups of Sprague-Dawley rats (230-260 g) were gavaged with a solution containing approximately 25 mg/kg Pb [as Pb(NO_3)2] plus 15 microCi "2"0"3Pb. Some groups were then immediately given 0.11 mmol/kg of either DMSA, CaNa2EDTA, D-penicillamine, or BAL by oral gavage, while other groups received the same drugs by ip injection. Control groups received solutions of the drug vehicles po or ip. Whole-body Pb retention and gastrointestinal Pb absorption (whole body retention + urinary Pb excretion) were significantly decreased in rats that received DMSA po. This finding implies that the use of DMSA to treat childhood lead intoxication on an outpatient basis is ...

268

Detection of pulmonary aspiration in infants and children with respiratory disease: concise communication  

Energy Technology Data Exchange (ETDEWEB)

Twenty children with respiratory disease ingested 500 ..mu..Ci of Tc-99m sulfur colloid orally, and scintigrams of the thorax were obtained to determine whether pulmonaryaspiration of gastric contents could be detected. The children ranged in age from 1 mo to 14 y; 13 were 8 months of age or younger. Children were studied at 5 min and 4 h after ingestion of Tc-99m sulfur colloid using a high-sensitivity computer oscilloscope to record 100K-count images. Additional images were obtained after the children had slept overnight. Five children (25%) showed definite pulmonary accumulation of activity; four of these also had a barium swallow and three showed either pulmonary aspiration of barium or moderately severe gastroesophageal reflux. Oral ingestion of Tc-99m sulfur colloid provides a noninvasive means for diagnosing pulmonary aspiration under physiologic conditions in infants and children.

1980-04-01

269

Dental caries in adolescents with attention deficit hyperactivity disorder: a population-based follow-up study  

British Library Electronic Table of Contents (United Kingdom)

Blomqvist M, Ahadi S, Fernell E, Ek U, Dahllf G. Dental caries in adolescents with attention deficit hyperactivity disorder: a population-based follow-up study. Eur J Oral Sci 2011; 119: 381-385. 2011 Eur J Oral Sci This study tested the hypothesis that adolescents with attention deficit hyperactivity disorder (ADHD) exhibit a higher prevalence of caries than adolescents in a control group. Thirty-two adolescents with ADHD and a control group of 55 adolescents from a population-based sample, all 17-yr of age, underwent a clinical and radiographic dental examination. The mean--SD number of decayed surfaces (DS) was 2.0--2.2 in adolescents with ADHD and 0.9--1.4 in adolescents of the control group. Thirty-one per cent of the adolescents in the ADHD group had no new caries lesions (DS-=-0) co...

2011-01-01

270

Construction and evaluation of a double mutant of Shigella flexneri as a candidate for oral vaccination against shigellosis.  

Science.gov (United States)

Based on studies on the genetic and molecular basis of Shigella flexneri invasive properties, we have constructed and evaluated a double mutant of S. flexneri serotype 5 for utilization as a live attenuated oral vaccine against shigellosis. The first mutation, icsA, blocks intracellular spread of bacteria as well as cell-to-cell infection. It affects the capacity of the invasive pathogen to form large abscesses in epithelia. The second mutation, iuc, eliminates production of the siderophore aerobactin thus impairing growth of the bacterium within tissues. This double mutant, SC5700 appeared safe when administered intragastrically to macaque monkeys as three doses (5 x 10(10) c.f.u. each) at weekly intervals. Protection against a challenge by the wild type isolate (M90T) was observed 4 weeks after the last vaccine inoculation. Duration of carriage was considerably reduced as compared to the control group in which all animals had developed severe dysentery. ...

1989-10-01

271

The use of oxygen isotopic composition to study water dynamics in Amazon floodplain lakes  

International Nuclear Information System (INIS)

The lakes formed in the Amazon floodplain play a key role in sustaining the highest populational density in the Amazon Basin because of its high primary productivity. The water volume in these lakes vary greatly during the year and possible water sources are the feeding river during high water state of the hydrographs and local inputs from its drainage basin. As these sources are chemically distinct, to understand the nutrient dynamics in these lakes, it is very important to know the relative water contribution of different water sources. In this paper we use "1"8O as a conservative to know the water sources for the lakes and our hypothesis is that: 1) In the high water stage lake water is derived predominantly from its feeding river. Therefore their #delta#"1"8O should be similar. 2) In the low water stage lake water is a mixture of watershed and last flood event waters. In this case, lake #delta#"1"8O should be indicative of the relative ...

1989-05-01

272

Testing of CoTreat Inorganic Ion Exchange Media for the Removal of 60Co from Thorp Pond Water  

Energy Technology Data Exchange (ETDEWEB)

CoTreat, a new inorganic ion exchange media, has been studied in the laboratory to support its application as a pre- coat to existing Funda filters in THORP feed pond plant (Sellafield, UK). This is a novel way of application of CoTreat, which is usually utilized in fixed-bed ion exchange columns in a granular form. The results present the effect of operating conditions (CoTreat dose, pond water chemistry) on CoTreat performance for the removal of Co-57 tracer from simulated pond water. Major findings include the strong dependence of Co-57 decontamination factor (DF) on feed activity. At the 200 Bq/L feed level, the observed DF was 10-20 but rose to 1000 and above when the feed level was increased to 20000 Bq/L. Calcium present in the feed was found to decrease the DF at concentrations higher than 1 ppm. The laboratory studies showed significantly higher DF's than what has ...

2003-02-25

273

Exhaust-catalyst development for methanol-fueled vehicles. 3. Formaldehyde oxidation  

Energy Technology Data Exchange (ETDEWEB)

Formaldehyde oxidation was examined in a laboratory reactor over alumina-supported Pt, Pd, Rh, Ag, Cu-Cr, and Pd-Ag catalysts as part of a program to develop catalysts for lean-exhaust methanol-fueled vehicles. In general, the H/sub 2/CO oxidation behavior of the catalysts paralleled the CH/sub 3/OH oxidation behavior reported in Parts 1 and 2 of this series (Appl. Catal. 27(1986) 83; J. Catal. 103(1987) 419). Principal similarities were: high activity of Pt when there was no carbon monoxide (CO) in the feed, but strong inhibition by added CO; lower activity of Ag and Cu-Cr catalysts, but only weak inhibition due to added CO; enhanced activity of the Pd-Ag catalyst compared to Pd and Ag alone for feeds containing CO in addition to H/sub 2/CO; and, relatively poor activity of the Rh catalyst. The most unusual behavior was observed with the Pd catalyst, which showed local minima in the H/sub 2/CO conversion vs. temperature profiles. These saddles ...

1988-11-15

274

Evaluating spatial patterns of dioxins in sediments to aid determination of potential implications for marine reptiles  

Energy Technology Data Exchange (ETDEWEB)

Recent investigations have identified elevated concentrations of polychlorinated dibenzo-p-dioxins (dioxins) in marine sediments and wildlife of Queensland, Australia. While it has been demonstrated that the contamination is widespread and predominantly land-based, limited information exists on the pathways and fate of these compounds within the near-shore marine system. This environment supports unique and threatened species including green sea turtles (Chelonia mydas). Adult green turtles are predominantly herbivorous, feeding on seagrass and algae. Apart from initial migration to feeding grounds (at {proportional_to}10 years of age) and intermittent migrations to breeding grounds (at {proportional_to}30-50 years and thereafter), green turtles remain and feed within relatively small home ranges. Long life-span (50 years or more), near-shore feeding grounds and highly specialized food requirements ...

2004-09-15

275

Use of the K88 antigen for in vivo bacterial competition with porcine strains of enteropathogenic Escherichia coli.  

Science.gov (United States)

Infant mice were used to measure the amount of fluid accumulation (enterosorption) in the intestinal tract after oral inoculation of a porcine strain of enteropathogenic Escherichia coli (K88-+, Ent-+). Significant reduction in the amount of fluid found in the intestinal tract was observed if the mice were first inoculated with a K88-possessing, non-enterotoxigenic strain of E. coli. The protection provided is thought to be due to specific competition for attachment sites on cells of the small intestine. PMID:1095492

1975-07-01

276

The effects of cefazolin on cirrhotic patients with acute variceal hemorrhage after endoscopic interventions  

British Library Electronic Table of Contents (United Kingdom)

Background The American Association for the Study of Liver Diseases (AASLD) guidelines recommend that antibiotic prophylaxis should be instituted in any patient with cirrhosis and gastrointestinal hemorrhage, and that oral norfloxacin, intravenous ciprofloxacin, and ceftriaxone are preferable. However, the antimicrobial spectrum of the first generation of cephalosporins (cefazolin) covers a wide range of bacteria species, including community-acquired strains of Escherichia coli and Klebsiella pneumoniae, but their efficacy as prophylactic antibiotics in cirrhotic patients with acute hemorrhage was seldom warranted in the literature. This study aimed to explore the effects of cefazolin on the outcome of cirrhotic patients with acute variceal hemorrhage after endoscopic interventions. Method...

2011-01-01

277

Rapid preparation of pyrogen-free 2H2(18)O for human-nutrition studies  

International Nuclear Information System (INIS)

We describe a compact ultrafiltration system for the removal of pyrogens and bacteria from water labeled with the stable isotopes of deuterium and oxygen-18. The ultrafiltration system is constructed from readily available commercial components and can achieve complete removal of pyrogens and bacteria from 1L contaminated water within 30 min. By use of our procedure, loss of the isotopically labeled water by retention in the filtration system was minimal. The purified water is suitable for both oral and intravenous administration to healthy human subjects participating in nutrition studies.

278

MRT of the abdomen in combination with enteroclysis in Crohn disease with oral and intravenous Gd-DTPA; MRT des Abdomens in Kombination mit der Enteroklyse bei Morbus Crohn unter Verwendung von oralem und intravenoesem Gd-DTPA  

Energy Technology Data Exchange (ETDEWEB)

60 patients between 17 and 72 years of age were investigated. First, an enteroclysis was performed in typical manner. The applicated methylcellulosis was blended with positive oral MR contrast media (Magnevist oral, Schering). After enteroclysis, MRI of the abdomen was performed using T1- and T2-weighted breathhold sequences (Flash 2D pre- and postcontrast and TSE) in axial and coronal planes. The length of the affected bowel and the stenosis seen with enteroclysis correlated well with the visible thickening of the small bowel wall and the stenosis seen in MRI. Using MRI, additional findings could be obtained in 28 patients, such as fistulas, abscesses or a hydronephrosis, or a better assessment of the stenosis was possible with MRI, because of the avoidance of overshadowing of the affected bowel loop with MRI. A brilliant MR-tomographic imaging of the small bowel is possible under the condition, that the small bowel contrast is optimal. The ...

1998-01-01

279

Influence of dietary amino acids on lead absorption  

International Nuclear Information System (INIS)

Dietary supplements of about 5 g/kg of a number of amino acids increased tissue lead concentrations in newly weaned rats but decreased them in older rats. The retention of both oral and intraperitoneal lead was affected. The uptake of "2"0"3Pb by tissues was reduced when methionine was given in the diet over a period of 5 weeks or when it or ethionine was given by mouth 24 h before the activity was measured. In the liver the fraction of the total activity found in the nuclei and mitochondria was increased by methionine, but in the kidney only the fraction found in nuclei was increased.

280

Drug eruptions presenting at sites of prior radiation damage (sunlight and electron beam)  

Energy Technology Data Exchange (ETDEWEB)

Two patients are described in whom sunburn and electron beam radiodermatitis, respectively, were critical determinants in localizing the initial presentation of drug eruptions. In the first instance, a severe sunburn of the back and thighs was followed 7 months later by the appearance of a toxic epidermal necrolysis drug reaction to trimethoprim-sulfamethoxazole in the exact sites of the previous bullous sunburn reaction. In the second patient, a radiodermatitis of the left upper arm due to electron beam therapy for metastatic breast cancer was followed 7 weeks later by a codeine drug reaction confined to the area of the radiodermatitis. In both instances, oral rechallenge with the offending drug reproduced the eruption.

1984-07-01

281

Advances in molecular biology: impact on rotavirus vaccine development.  

Science.gov (United States)

The first candidate rotavirus vaccine was a live attenuated oral vaccine made by the classical empirical method of serial passage of virus in tissue culture cells. Current tetravalent vaccine candidates that are in the final stages of efficacy testing in the United States were made by genetic reassortment. This article briefly highlights how advances in the basic understanding of the molecular biology of rotaviruses have facilitated vaccine development. New approaches for second-generation vaccines and improvements in vaccine efficacy based on further exploitation of the tools and knowledge of rotavirus molecular biology and pathogenesis are discussed. PMID:8752289

1996-09-01

282

Untitled Document  

Science.gov (United States)

integrates multiple fisheries information systems to obtain a view of U.S. freshwater fish distribution. Information about NFDI National Framework for Early Detection, Rapid...

2011-06-23

283

United States Space Activities - NASA  

Science.gov (United States)

Mission losses were incurred by an early warning satellite and a Milstar-2 communications satellite when their launch vehicles malfunctioned, the first, ...

284

US Forces in Iraq  

Science.gov (United States)

... Army 2nd Brigade, 82nd Airborne Division Fort Bragg, NC January, 2007 ... 1st Brigade, 82nd Airborne Division Fort Bragg, NC early-2007 ...

2007-01-11

286

The Arc of synaptic memory  

UK PubMed Central (United Kingdom)

The immediate early gene Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information...Full Text Available

2010-01-01

287

September 1995 Prototypes and Studies Status  

Science.gov (United States)

4) Expand to include client-server interaction (small-scale archive interactions with the goal of evaluating information management capabilities) -- Early ...

288

Role of Mast Cells in Early and Delayed Radiation Injury in Rat Intestine  

Science.gov (United States)

... mast cell staining; ref. 16). The severity of structural radiation injury was assessed using a histopathological radiation injury score ... ...

289

Remote Sensor Systems for Unmanned Planetary Missions  

Science.gov (United States)

instrument is shown in Figure 4-9 The incoming radiation is focused onto ...... An early rocket-borne ultraviolet spectrometer of the Ebert type by ...

290

Reduced activation activities  

Energy Technology Data Exchange (ETDEWEB)

Four low activation alloy classes, two austenitic and two ferritic, have been incorporated into the MOTA-1B experiment in the FFTF reactor to provide an early assessment of the suitability of such alloys for reactor service.

1984-01-01

291

Proteomic strategies in multiple sclerosis and its animal models  

UK PubMed Central (United Kingdom)

The early and precise diagnosis, the prognosis, and the clinical management of multiple sclerosis, remain a considerable challenge. In recent years, the development of novel and powerful proteomic...Full Text Available

2007-10-16

292

Pioneering the nuclear age  

Energy Technology Data Exchange (ETDEWEB)

This paper reviews the historical aspects of nuclear physics. The scientific aspects of the early transuranium elements are discussed and arms control measures are reviewed. 11 refs., 14 figs. (LSP)

1988-09-01

293

N94- 31026 - NASA Technical Report Server (NTRS)  

Science.gov (United States)

in early 1992 from Lord Corporation, were also found. For both the reflective and absorptive polyurethanes, the fresh paint fluoresces significantly ...

294

Minimising the stress of weaning of beef calves: a review  

UK PubMed Central (United Kingdom)

Weaning of beef calves is usually done abruptly and early compared to the natural weaning of the species, and is associated with simultaneous exposure of calves to a range of social and environmental...Full Text Available

296

MODELING AND BIOLOGICAL CONTROL OF MOSQUITOES  

UK PubMed Central (United Kingdom)

Models can be useful at many different levels when considering complex issues such as biological control of mosquitoes. At an early stage, exploratory models are valuable in exploring the characteristics...Full Text Available

2007-01-01

297

Intrapopulation Genome Size Dynamics in Festuca pallens  

UK PubMed Central (United Kingdom)

Background and AimsIt is well known that genome size differs among species. However, information on the variation and dynamics of genome size in wild populations and on the early...Full Text Available

2008-10-01

298

Interferons and the Maternal-Conceptus Dialog in Mammals  

UK PubMed Central (United Kingdom)

Two-way communication between the conceptus and the mother during early pregnancy is essential if the pregnancy is to survive. In this review, our primary focus is on biochemical communication...Full Text Available

2008-04-01

299

Improvement of early recognition of gesture patterns based on a self-organizing map  

British Library Electronic Table of Contents (United Kingdom)

We propose an approach to achieving early recognition of gesture patterns. Early recognition is a method for recognizing sequential patterns at their earliest stage. Therefore, in the case of gesture recognition, we can get a recognition result for human gestures before the gestures are finished. The most difficult problem in early recognition is knowing when the system has determined the result. Most traditional approaches suffer from this problem, since gestures are often ambiguous. At the start of a gesture, in particular, it is very difficult to determinate the recognition result since insufficient input data have been observed. Therefore, we have improved on the traditional approach by using a self-organizing map.

2011-01-01

300

GLYDER - Earth Science Technology Office (ESTO) - NASA  

Science.gov (United States)

goals for multisensor co-registration and fusion. 6 - 12.5 Km ..... Beta-Test toolkit for cyclogenesis and early evolution of cyclones ...

301

Fast Flux Test Facility performance monitoring management information, April 1988  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this report is to provide management with performance data on key performance indicators selected from the FFTF Early Warning System performance indicators.

1988-05-01

302

Evaluation of CFD to Determine Two-Dimensional Airfoil ...  

Science.gov (United States)

rotor flow field in which the main rotor operates. The majority of ..... early separation predicted by their CFD code was ...... Airfoil, AGARD Fluid Dynamics Panel ...

303

Environmental estrogens alter early development in Xenopus laevis.  

UK PubMed Central (United Kingdom)

A growing number of environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes....Full Text Available

2003-04-01

305

Do Perturbed Epithelial-Mesenchymal Interactions Drive Early ...  

Science.gov (United States)

... At the same time, we observed that the neoplastic properties of rat mammary gland tumor cells can be restrained and "normalized" so that they ...

2005-04-01

306

Dimorphic Olfactory Lobes in the Arthropoda  

UK PubMed Central (United Kingdom)

Specialized olfactory lobe glomeruli relating to sexual or caste differences have been observed in at least five orders of insects, suggesting an early appearance of this trait in insect evolution....Full Text Available

2009-07-01

307

Diagnostic Value of C-reactive Protein in Complicated Appendicitis  

UK PubMed Central (United Kingdom)

PurposeEarly detection of appendicitis has increased due to development of computed tomography and ultrasonography, yet we are frequently meeting complicated appendicitis, including...Full Text Available

2011-06-01

308

Color Fluorescence Ratio for Detection of Bronchial Dysplasia and Carcinoma In situ  

UK PubMed Central (United Kingdom)

BackgroundAutofluorescence bronchoscopy is more sensitive than conventional bronchoscopy for detecting early airway mucosal lesions. Decreased specificity can lead...Full Text Available

2009-07-15

309

Coke Making in the Beehive Oven.  

Science.gov (United States)

Documents an early American industrial process of making blast furnace coke using techniques and equipment from the 19th century. Photographed at Bretz, WV.

1994-01-01

310

Cloning of the neurodegeneration gene drop-dead and characterization of additional phenotypes of its mutation  

UK PubMed Central (United Kingdom)

Mutations in the Drosophila gene drop-dead (drd) result in early adult lethality and neurodegeneration, but the molecular identity of the drd...Full Text Available

2008-01-01

311

Bullet injuries of the brain  

UK PubMed Central (United Kingdom)

Experience gained with a wide variety of missile injuries of the brain is presented. Clinical signs and intracranial pressure (ICP) studied in the early post-injury period have been correlated with...Full Text Available

1974-09-01

312

An introduction to boron: history, sources, uses, and chemistry.  

UK PubMed Central (United Kingdom)

Following a brief overview of the terrestrial distribution of boron in rocks, soil, and water, the history of the discovery, early utilization, and geologic origin of borate minerals is summarized....Full Text Available

1994-11-01

313

Respiratory responses of young asthmatic volunteers in controlled exposures to sulfuric acid aerosol  

Energy Technology Data Exchange (ETDEWEB)

Thirty-two asthmatic volunteers 8 to 16 yr of age, recruited through local schools and private physicians, were exposed in a chamber to clean air (control condition) and to sulfuric acid aerosol at a low concentration (46 +/- 11 micrograms/m3; mean +/- SD) and at a high concentration (127 +/- 21 micrograms/m3). Acid aerosols had mass median aerodynamic diameters near 0.5 microns with geometric standard deviations near 1.9. Temperature was 21 degrees C, and relative humidity was near 50%. Subjects were exposed with unencumbered oronasal breathing for 30 min at rest plus 10 min at moderate exercise (ventilation rate approximately 20 L/min/m2 of body surface). A subgroup (21 subjects) were exposed similarly to clean air and to high acid (134 +/- 20 micrograms/m3) with 100% oral breathing. Increased symptoms and bronchoconstriction were found after exercise under all exposure conditions. For the group, symptom and lung function responses were not statistically ...

1990-08-01

314

Recruitment of intestinal CD45RA+ and CD45RC+ cells induced by a candidate oral vaccine against porcine post-weaning colibacillosis.  

Science.gov (United States)

To assess the influence of a live attenuated oral vaccine against porcine post-weaning colibacillosis (PWC) induced by enterotoxigenic Escherichia coli (ETEC) on mucosal lymphoid cell CD45 isoforms expression, experimental group of weaned pigs (n=6) was immunized orally with F4ac+ non-ETEC strain (day 0) and challenged with F4ac+ ETEC strain 7 days latter. Non-immunized ETEC-infected pigs (n=6) served as control. All pigs were killed on post-challenge day 7. The small intestine was excised for isolation of jejunal lamina propria (JLP) and ileal Peyer's patch (IPP) lymphocytes and immunohistochemical studies. The results obtained by immunophenotyping of isolated cells show that the proportion of CD45RA+ and CD45RC+ JLP, but not IPP, cells were higher in the non-ETEC-immunized ETEC-infected pigs versus non-immunized infected. Additionally, while CD45RA+ JLP cells increased only slightly, the expression of CD45RC isoform on the JLP cells was ...

2002-07-01

315

A 4-week oral toxicity study of an antiviral drug combination consisting of arbidol and acetaminophen in rats.  

Science.gov (United States)

The antiviral drug combination consisting of arbidol and acetaminophen was investigated for its 4-week repeated oral administration in Sprague-Dawley rats. Groups of rats (10/sex in low-dose group, 15/sex in other three groups) were given at doses of 0, 200, 400, and 800 mg/kg/day. Clinical signs, mortality, body weight, food consumption, hematology, clinical biochemistry, macroscopic findings, organ weights, and histopathology were examined. The administration resulted in increased incidence of piloerection in most of the high-dose females and in some of the high-dose males and mid-dose females. Histopathological examinations revealed minor treatment-related change in the stomach of the high-dose animals. A decrease in body-weight gains and an increase in liver weight were observed in the mid- and high-dose groups. These treatment-related effects were reversible at the 2-week recovery period. A number of other clinical and pathological findings were not considered ...

2010-07-01

316

Simultaneous biosorption of chromium(VI) and copper(II) on Rhizopus arrhizus in packed column reactor: Application of the competitive Freundlich model  

Energy Technology Data Exchange (ETDEWEB)

The simultaneous biosorption of Cr(VI) and Cu(II) on free Rhizopus arrhizus in a packed column operated in the continuous mode was investigated and compared to the single metal ion situation. The breakthrough curves were measured as a function of feed flow rate, feed pH, and different combinations of metal ion concentrations in the feed solutions. Column competitive biosorption data were evaluated in terms of the maximum (equilibrium) capacity in the column, the amount of metal loading on the R. arrhizus surface, the adsorption yield, and the total adsorption yield. In the single-ion situation the adsorption isotherms were developed for optimum conditions, and it was seen that the adsorption equilibrium data fit the noncompetitive Freundlich model. For the multicomponent adsorption equilibrium the competitive adsorption isotherms were also developed. The competitive Freundlich model for binary metal mixtures represented ...

1999-12-01

317

Serviceability of steam generators at NPPs with reactors of the WWER-440 and WWER-1000 types  

Energy Technology Data Exchange (ETDEWEB)

Steam generators (SG) are the weak link of nuclear power plants, their service life is shorter than the service life of other NPP components. This paper is dedicated to a statistical analysis of SG damages and failures. Heat exchanging tubes (HET) are the most damaged elements in SG, there are on average 286 plugged or repaired tubes in each operating SG. The usually mechanisms of tube failure are the following: denting, corrosion at tube outside, pitting, fretting, and circular crack propagation. Most of damages are located in the transition zone above a tube plate. This study shows that the factors that are involved in the SG HET fault probability are: - design features of SG and secondary equipment elements (high pressure feed heaters (HPFH), low pressure feed heater (LPFH)), - water chemistry at different points of condensate feed pipe, composition and density of deposits on HET surface, efficiency of mechanical and ...

2002-07-01

318

Replacement of fishmeal in cobia (Rachycentron canadum) diets using poultry by-product meal  

British Library Electronic Table of Contents (United Kingdom)

An 8-week feeding trial was conducted to evaluate the use of local poultry by-product meal (PBM) in replacement of imported fishmeal in the diets of cobia, Rachycentron canadum. Six isolipidic (12%) and isoproteic (45%) experimental diets were formulated using PBM to replace fishmeal at 20, 40, 60, 80 and 100% dietary protein. Eleven juvenile cobia (initial mean weight of 30.7???0.78?g) were randomly stocked in 300-L circular fibreglass tanks and hand-fed based on the total biomass of each tank, twice a day at 0900?h and 1500?h. The fish were group weighed at 2-week intervals to monitor their growth performance in order to adjust the feeding ratio. At the end of the feeding trial, weight gains (WGs) ranging from 221 to 322% were obtained. The specific growth rate (SGR), WG and protein effi...

2011-01-01

319

Radioimmunoassay determination of the effect on animal reproduction of alternative of feeding suplementation in dairy cows  

International Nuclear Information System (INIS)

The principal object of this trial was to evaluate the influence of three alternatives of feeding suplementation in dairy cows in the post-partum period in ecuadorian highlands. Thirty sic animals in fist lactation were used in this experiment and were divided in three groups according to the feed intake: Group A diet was 5 Kg. of a commercial concentrate mixture with 12 per cent of crude protein plus pasture ad libitum; Group B diet was green banans (Musa paradisiaca) and pasture and Group C diet was the control only pasture. Using Radioimmunoassay technique (RIA), progesterone values were determinated in milk from each cow. the sampling was sequential, two samples a week, starting 6 days after parturition, until the animal was pregnant or until the study was finished, 150 days after post-partum for each cow. This research allowed us to evaluate the ovaric post-partum activity of each group: Frequency and length of the oestrus cycles; ...

320

Influence of nutrition on ovulation rate and testicular growth of Merino sheep  

International Nuclear Information System (INIS)

The effect of nutrition on reproductive performance was studied in a series of experiments using two models. Increased supply of nutrients was based on feeding lupin grain as a supplement and measurements of testicular growth or ovulation rates were used to measure reproductive characteristics. Purified sources of protein and energy were provided to determine the macronutrient(s), supplied with lupin feeding, responsible for initiating increases in testicular growth and ovulation rate. Increases in both of these parameters were closely related to the supply of additional energy but not protein. The production of acetate and glucose resulting from supplementary feeding with 750 g lupins/d was measured using infusions of "1"4C tracers. Subsequently, infusions of glucose and acetate (individually and in combination) were found to produce similar increases in ovulation rate to those measured in ewes receiving lupins. It was ...

1987-03-01

321

Fuzzy-decision-making problems of fuel ethanol production using a genetically engineered yeast  

Energy Technology Data Exchange (ETDEWEB)

A fuzzy-decision-making procedure is applied to find the optimal feed policy of a fed-batch fermentation process for fuel ethanol production using a genetically engineered Saccharomyces yeast 1400 (pLNH33). The policy consisted of feed flow rate, feed concentration, and fermentation time. The recombinant yeast 1400 (pLNH33) can utilize glucose and xylose simultaneously to produce ethanol. However, the parent yeast utilizes glucose only. A partially selective model is used to describe the kinetic behavior of the process. In this study, this partially selective fermentation process is formulated as a general multiple-objective optimal control problem. By using an assigned membership function for each of the objectives, the general multiple-objective optimization problem can be converted into a maximizing decision problem. In order to obtain a global solution, a hybrid method of differential evolution is introduced to solve ...

1998-08-01

322

Control of the reduction/oxidation potential of Hanford Waste Vitrification Plant feeds  

International Nuclear Information System (INIS)

A schematic diagram shows the various processing steps to be performed during feed preparation in the Hanford Waste Vitrification Plant (HWVP). The pretreated NCAW is transferred to the slurry receipt adjustment tank (SRAT) in the HWVP for concentration. Water removed during boildown is collected in the slurry mix evaporator condensate tank (SMECT). After waste treatment the water is returned to the storage tanks for eventual disposal. The pretreated Neutralized Current Acid Waste (NCAW) is concentrated in the SRAT to approximately 125 g waste oxides/ liter. Formic acid is then added at a controlled rate to improve rheological properties and achieve a required reduction/oxidation state. Reflux boiling is initiated and continued for several hours. The concentrated slurry is cooled and pumped to the slurry mix evaporator (SME). In the SME, glass frit is added, and the slurry is further concentrated to achieve a nominal composition of 500 g total oxides/liter. This ...

1988-09-11

323

Calcination of Fluorinel-sodium waste blends using sugar as a feed additive (formerly WINCO-11879)  

Energy Technology Data Exchange (ETDEWEB)

Methods were studied for using sugar as a feed additive for converting the sodium-bearing wastes stored at the Idaho Chemical Processing Plant into granular, free flowing solids by fluidized-bed calcination at 500{degrees}C. All methods studied blended sodium-bearing wastes with Fluorinel wastes but differed in the types of sugar (sucrose or dextrose) that were added to the blend. The most promising sugar additive was determined to be sucrose, since it is converted more completely to inorganic carbon than is dextrose. The effect of the feed aluminum-to-alkali metal mole ratio on calcination of these blends with sugar was also investigated. Increasing the aluminum-to-alkali metal ratio from 0.6 to 1.0 decreased the calcine product-to-fines ratio from 3.0 to 1.0 and the attrition index from 80 to 15%. Further increasing the ratio to 1.25 had no effect.

1992-06-01

324

Antihemostatic molecules from saliva of blood-feeding arthropods.  

Science.gov (United States)

The ability to feed on vertebrate blood has evolved many times in various arthropod clades. Each time this trait evolves, novel solutions to the problem posed by vertebrate hemostasis are generated. Consequently, saliva of blood-feeding arthropods has proven to be a rich source of antihemostatic molecules. Vasodilators include nitrophorins (nitric oxide storage and transport heme proteins), a variety of peptides that mimic endogenous vasodilatory neuropeptides, and proteins that catabolize or sequester endogenous vasoconstrictors. A variety of platelet aggregation inhibitors antagonize platelet responses to wound-generated signals, including ADP, thrombin, and collagen. Anticoagulants disrupt elements of both the intrinsic and extrinsic pathways. Molecular approaches (termed 'sialomics') to characterize the full inventory of mRNAs transcribed in salivary glands have revealed a surprising level of complexity within a single species. Multiple ...

2005-01-01

325

Process development for continuous crystallization of fat under laminar shear  

British Library Electronic Table of Contents (United Kingdom)

A novel continuous laminar shear structuring crystallizer with a suitable cooling system was designed and built. This is a new method to continuously crystallize edible fat in the desirable polymorphic form from the melt while being uniformly sheared.The machine consists of four main sections: Feed unit, shearing mechanism, cooling system and power unit. In each of these sections specific design considerations are taken into account which makes the process controllable and continuous. The shearing unit is made of two concentric cylinders. The internal cylinder is stationary and has a cooling system inside for temperature control. The outer cylinder rotates to produce a uniform shear in the sample fluid placed in the 1.5mm gap between the cylinders. The sample's feed rate is controlled whil...

2008-01-01

326

Poliphili: A Renaissance dream banquet  

British Library Electronic Table of Contents (United Kingdom)

Francesco Colonnas Hypnerotomachia Poliphili (The Strife of Love in a Dream) of 1499 is a bizarre architectural-erotic fantasy whose imagery has often perplexed commentators. One particular banquet scene has defied scrutiny. This paper decodes the meal as a typical Renaissance banquet, as harmonious and balanced as any painting or edifice, yet offering an image of divine feeding. The flavors, ingredients and meal structure all reflect current culinary aesthetics as well as Neo-Platonic love theory, occult symbolism and humoral medicine. The banquet scene features foods and cooking methods which were popular in late 15th century Italy and yet includes exotic ingredients such as precious jewels and perfumes which were meant to denote divine feeding. For example, a confection served as a star...

2006-01-01

327

Persistent halogenated compounds in two typical marine aquaculture zones of South China  

British Library Electronic Table of Contents (United Kingdom)

Samples of two seawater farmed fish (crimson snapper (Lutjanus erythopterus) and snubnose pompano (Trachinotus blochii)), water, air, sediment, fish feed, macroalgae and phytoplankton were collected from two estuarine bays (Daya Bay and Hailing Bay) in South China. The concentrations of persistent halogenated compounds (PHCs) including polybrominated diphenyl ethers (PBDEs), organochlorine pesticides and polychlorinated biphenyls (PCBs) varied widely with the different sample matrices under investigation. The compositional patterns in fish, fish feed, macroalgae and phytoplankton, as well as the good correlations between the abundances of p,pprime-DDT and BDE-209 and their metabolites (i.e., p,pprime-DDD and p,pprime-DDE for p,pprime-DDT and BDE-47 for BDE-209) in fish indicated the occurr...

2011-01-01

328

Nuclear techniques for measuring moisture content in soil profiles  

International Nuclear Information System (INIS)

The prevailing severe shortage of animal feed in most of the developing countries could, to a considerable extent, be overcome through improved range management, which includes introduction of high yielding drought-resistant forage crops, development of adequate water conservation measures, and as far as possible growing annual forage crops on part of the vast areas of arable land currently left fallow each year. Year round measurements are essential for a good understanding of soil water and nutrients dynamics, which allow for adequate evaluation of pasture management alternatives. The methods most commonly used for moisture measurements in soil profiles are discussed because such measurements are likely to form an essential part of any investigation aimed at increasing animal feed production through the development of adequate pasture management practices. (author).

329

Integrated coke, asphalt and jet fuel production process and apparatus  

Science.gov (United States)

A process and apparatus for the production of coke, asphalt and jet fuel m a feed of fossil fuels containing volatile carbon compounds therein is disclosed. The process includes the steps of pyrolyzing the feed in an entrained bed pyrolyzing means, separating the volatile pyrolysis products from the solid pyrolysis products removing at least one coke from the solid pyrolysis products, fractionating the volatile pyrolysis products to produce an overhead stream and a bottom stream which is useful as asphalt for road pavement, condensing the overhead stream to produce a condensed liquid fraction and a noncondensable, gaseous fraction, and removing water from the condensed liquid fraction to produce a jet fuel-containing product. The disclosed apparatus is useful for practicing the foregoing process. the process provides a useful method of mass producing and jet fuels from materials such as coal, oil shale and tar sands.

1991-01-01

330

Influence of feed water distribution pipe replacement on the water chemistry in the steam generator at Loviisa NPP  

International Nuclear Information System (INIS)

Imatran Voima Oy , (IVO) operates two Russian designed nuclear power plants of type VVER440/213. Unit 1 has been operating since 1977 and unit 2 since 1981. First damage of feed water distribution (FWD) pipes was observed in 1989. In closer examinations FWD-pipe T-connection and distribution nozzles suffered from severe erosion corrosion damage. Similar damages have been found also in other VVER-440 type NPPs. In 1994 the first FWD-pipe was replaced by a new design mounted over the tube bundle instead of the old FWD-pipe, which was located inside the tube bundle. The purpose of this paper is to describe the new FWD-pipe and discuss its effects on the steam generator chemistry. (author)

1998-06-01

331

Infant well-being following neonatal cardiac surgery  

British Library Electronic Table of Contents (United Kingdom)

Aims and objectives.- To investigate infant well-being as measured by feeding and sleeping and parental support following discharge from the NICU in infants following major cardiac surgery. Background.- Infant feeding and sleeping have been identified as two of the most important concerns reported by parents. These concerns have been reported anecdotally for infants who have undergone cardiac surgery in the neonatal period. Design.- A prospective study using questionnaires and phone interviews followed a cohort of parents of neonates who underwent surgery in the neonatal period for congenital heart disease. Methods.- The study was conducted using validated questionnaires and phone interviews with a semi-structured questionnaire. The questionnaires were administered prior to discharge from ...

2011-01-01

332

Feeding ecology of mesopelagic zooplankton of the subtropical and subarctic North Pacific Ocean determined with fatty acid biomarkers  

British Library Electronic Table of Contents (United Kingdom)

Mesopelagic zooplankton may meet their nutritional and metabolic requirements in a number of ways including consumption of sinking particles, carnivory, and vertical migration. How these feeding modes change with depth or location, however, is poorly known. We analyzed fatty acid (FA) profiles to characterize zooplankton diet and large particle (>51?m) composition in the mesopelagic zone (base of euphotic zone ?1000m) at two contrasting time-series sites in the subarctic (station K2) and subtropical (station ALOHA) Pacific Ocean. Total FA concentration was 15.5 times higher in zooplankton tissue at K2, largely due to FA storage by seasonal vertical migrators such as Neocalanus and Eucalanus. FA biomarkers specific to herbivory implied a higher plant-derived food sou...

2010-01-01

333

Effects of Dietary Glycyrrhizin on Growth and Nonspecific Immunity of White Shrimp, Litopenaeus vannamei  

British Library Electronic Table of Contents (United Kingdom)

The growth response, total hemocyte count (THC), respiratory burst (release of superoxide anion), phenoloxidase (PO) activity, superoxide dismutase (SOD) activity, nitric oxide synthase (NOS) activity as well as resistance to the pathogen Vibrio alginolyticus were measured in Litopenaeus vannamei, which had been fed diets supplemented with glycyrrhizin (the aqueous extract of licorice, Glycyrrhiza glabra, roots) at 0, 50, 100, 150, and 200 mg/kg of feed for 8 wk. In the feeding trial, there was no significant difference in survival rate (P > 0.05). Significant higher specific growth rate was observed in treatments with dietary glycyrrhizin than that in the control group (P < 0.05). Shrimp fed a diet with 200 mg/kg of glycyrrhizin had significant higher THC, PO activity, respiratory burst a...

2010-01-01

334

Development and operational experience of traveling in core probe drive for flux scan of 540 MWe PHWR of Tarapur  

International Nuclear Information System (INIS)

TAPP-3 and 4 reactors use large number of Self Powered Neutron Detectors (SPNDs) for Neutronic lower measurement and control. To perform in-situ calibration of these detectors in select locations and to validate the reactor physics codes which predict flux at various points in the core, traveling in-core probes (TIP) are required. The TIP assembly consists of a miniature neutron sensitive detector. The detector is driven in and out of core using a mechanism which facilitates positioning of the detector anywhere inside a vertical tube (Central carrier tube of any of the six select Vertical Flux Units) in the core. TIP is driven through retractable feed mechanism for a stroke of 13 m. This paper describes the developmental efforts and the operational feedback of the retractable feed mechanism for the stroke of 13 m used at TAPP 3 and 4 reactor. (author)

2006-11-13

335

Concentration of Melton Valley Storage Tank surrogates with a wiped film evaporator  

Energy Technology Data Exchange (ETDEWEB)

This report describes experiments to determine whether a wiped film evaporator (WFE) might be used to concentrate low-level liquid radioactive waste (LLLW). Solutions used in these studies were surrogates that contain no radionuclides. The compositions of the surrogates were based on one of Oak Ridge National Laboratory`s (ORNL`s) Melton Valley Storage Tanks (MVSTs). It was found that a WFE could be used to concentrate LLLW to varying degrees by manipulating various parameters. The parameters studied were rotor speed, process fluid feed temperature and feed rate, and evaporator temperature. Product consistency varied from an unsaturated liquid to a dry powder. Volume reductions up to 68% were achieved. System decontamination factors were consistently in the range of 10{sup 4}.

1994-08-01

336

Comparison of stomach contents and condition of two catfish species living at ambient temperatures and in a heated discharge  

International Nuclear Information System (INIS)

The lower condition factors for two catfish species in water heated by effluents from APCo's Glen Lyn, Virginia plant as compared to control areas probably is not due to lack of food as evidenced by macroinvertebrate sampling and the fact that only 4.3 percent of the catfish stomachs were empty. Results suggested that young-of-the-year channel catfish were nonselectively eating food organisms present at both control and heated stations. The difference between stomach contents of flatheat catfish from the heated site and fauna available at that site indicated that fish were either moving out of the heated area to feed or were selectively feeding on organisms (particularly mayflies) which were in the substrate or drifted into the heated area. Stomach contents of the two species and distribution and abundance of the macroinvertebrate benthos community are detailed.

337

Cats and goat whey associated with Toxoplasma gondii infection in pigs.  

Science.gov (United States)

In organic livestock production systems, farm-management factors are thought to play an important role in the on-farm prevalence of Toxoplasma gondii. Serological results and the results of an HACCP analysis were combined to determine important risk factors for the prevalence of this protozoan parasite. Mathematical analysis demonstrated that feeding goat whey to pigs and the presence of a high number of cats were positively correlated to T. gondii seroprevalence in pigs. Not covering roughage and the farmers' assumption that pigs can come into contact with cat feces also showed a positive relationship. In order to decrease the risk of T. gondii infecting their pigs, farmers should limit the access and number of cats on their farms and refrain from feeding goat whey to their pigs. PMID:16989566

2006-01-01

338

Bioprocess control from a multivariate process trajectory.  

Science.gov (United States)

A multivariate bioprocess control approach, capable of tracking a pre-set process trajectory correlated to the biomass or product concentration in the bioprocess is described. The trajectory was either a latent variable derived from multivariate statistical process monitoring (MSPC) based on partial least squares (PLS) modeling, or the absolute value of the process variable. In the control algorithm the substrate feed pump rate was calculated from on-line analyzer data. The only parameters needed were the substrate feed concentration and the substrate yield of the growth-limiting substrate. On-line near-infrared spectroscopy data were used to demonstrate the performance of the control algorithm on an Escherichia coli fed-batch cultivation for tryptophan production. The controller showed good ability to track a defined biomass trajectory during varying process dynamics. The robustness of the control was high, despite significant external ...

2003-09-05

339

Unusual heterogeneity of the 5'-termini of human adenovirus type 2 early region E2 mRNA.  

UK PubMed Central (United Kingdom)

The 5'-terminal structures of human adenovirus type 2 (Ad2) early region 2 (E2) mRNA were investigated. The E2 transcription unit has several interesting properties, including the presence of a TATA-like...Full Text Available

1984-12-11

340

The spoIIE homolog of Epulopiscium sp. type B is expressed early in intracellular offspring development.  

Science.gov (United States)

Epulopiscium sp. type B is an enormous intestinal symbiont of the surgeonfish Naso tonganus. Intracellular offspring production in Epulopiscium shares features with endospore formation. Here, we characterize the spoIIE homolog in Epulopiscium. The timing of spoIIE gene expression and presence of interacting partners suggest that the activation of ?(F) occurs early in Epulopiscium offspring development. PMID:21398534

2011-03-11

341

The Putative Natural Killer Decoy Early Gene m04 (gp34) of Murine Cytomegalovirus Encodes an Antigenic Peptide Recognized by Protective Antiviral CD8 T Cells  

UK PubMed Central (United Kingdom)

Several early genes of murine cytomegalovirus (MCMV) encode proteins that mediate immune evasion by interference with the major histocompatibility complex class I (MHC-I) pathway of antigen presentation...Full Text Available

2000-02-01

342

Specific in vitro initiation of transcription on the adenovirus type 2 early and late EII transcription units.  

UK PubMed Central (United Kingdom)

Three transcription units are present in the adenovirus type 2 region EII. Transcription units EIIaE and EIIaL encode the mRNA for the 72,000-dalton DNA binding protein, early and late in the lytic...Full Text Available

1981-12-01

343

Research - Keyword Index  

Wastenet

...notice de en es fr it nl European Commission Research Index aeronews All keywords Index feedback The number of documents that contain the keyword aeronews is: 1 EU Transport lsquo;AERONEWSrsquo; -good news for early detection of microdamage European Commission - lsquo;AERONEWSrsquo; -good news for early detection of microdamage ...

344

Nucleosynthesis in early supernova winds III: No significant contribution from neutron-rich pockets  

CERN Document Server

Recent nucleosynthesis calculations of Type II supernovae using advanced neutrino transport determine that the early neutrino winds are proton-rich. However, a fraction of the ejecta emitted at the same time is composed of neutron-rich pockets. In this paper we calculate the nucleosynthesis contribution from the neutron-rich pockets in the hot convective bubbles of a core-collapse supernova and show that they do not contribute significantly to the total nucleosynthesis.

2007-01-01

345

Inguino-scrotal hernia detection in the early phase of a bone scan  

International Nuclear Information System (INIS)

A large inguino-scrotal hernia was detected in the early phase of a radionuclide bone scan performed for evaluation of a femoral neck fracture not visualized on plain x-rays. The patient was administered 1 GBq of Scrotal scintigraphy using "9"9"mTc-MDP and a regional three-phase bone scan of the pelvis, hips and proximal femora was obtained on the gamma camera. Copyright (1999) Blackwell Science Pty Ltd

1999-11-01

346

In vivo99mTc-HYNIC-annexin V imaging of early tumor apoptosis in mice after single dose irradiation  

UK PubMed Central (United Kingdom)

BackgroundApoptosis is a major mode of hematological tumor death after radiation. Early detection of apoptosis may be beneficial for cancer adaptive treatment. 99mTc-HYNIC-annexinV...Full Text Available

347

Clinical translation of ultraviolet autofluorescence microscopy towards endomicroscopy for early detection of cancer  

Science.gov (United States)

The non-invasiveness of autofluorescence technology may reduce sampling error and time delay for histopathology diagnosis. We establish biophotonic methods and guidelines to visualize and interpret early epithelial tissue changes that signify disease. Flexible and rigid fiber endomicroscopy instrumentation design parameters feasible for translation towards clinical use are in development.

2010-12-01

348

Ageing and the environment: the effects of early nutrition and reproductive effort on senescence in birds.  

Environmental Research Database

DescriptionThe overall aim of this application is to examine experimentally environmental influences on the pattern of senescence in birds. We plan to experimentally uncouple chronological age and reproductive effort and examine their effects on reproductive performance and lifespan. We also plan to examine experimentally how these relationships are influenced by nutritional conditions during early development. We will combine the organismal fitness measures of lifespan and reproductive performance with me [continued...

2005-01-30

349

A single early life seizure impairs short-term memory but does not alter spatial learning, recognition memory, or anxiety  

UK PubMed Central (United Kingdom)

The impact of a single seizure on cognition remains controversial. We hypothesized that a single early life seizure (sELS) on rat post-natal day (P) 7 would alter only hippocampal-dependent...Full Text Available

2008-11-01

350

Utilization of intestinal triglyceride-rich lipoproteins in mammary gland of cows.  

Science.gov (United States)

Elution profiles of total lipoproteins, apolipoprotein B (apoB) concentrations in lipoproteins, and plasma triglyceride (TG) levels were examined in early-, late-, and non-lactating cows. Additionally, arteriovenous (A-V) differences were also measured to elucidate the uptake of TG and apoB-containing lipoproteins in mammary gland. Non-lactating cows showed three major peaks corresponding to triglyceride-rich lipoprotein (TRL), low density lipoprotein (LDL), and high density lipoprotein (HDL) fraction, whereas both early- and late-lactating cows revealed two peaks corresponding to TRL and HDL. The peak area of TRL in early- and late-lactating cows were significantly (p < 0.05) smaller than that in non-lactating cows. The plasma TG levels and apoB-48 concentrations of TRL in early- and late-lactating cows were also significantly (p < 0.01) lower. Furthermore, early lactating ...

1999-10-01

351

An Ecological Risk Model for Early Childhood Anxiety: The Importance of Early Child Symptoms and Temperament  

Science.gov (United States)

Childhood anxiety is impairing and associated with later emotional disorders. Studying risk factors for child anxiety may allow earlier identification of at-risk children for prevention efforts. This study applied an ecological risk model to address how early childhood anxiety symptoms, child temperament, maternal anxiety and depression symptoms, violence exposure, and sociodemographic risk factors predict school-aged anxiety symptoms. This longitudinal, prospective study was conducted in a representative birth cohort (n = 1109). Structural equation modeling was used to examine hypothesized associations between risk factors measured in toddlerhood/preschool (age = 3.0 years) and anxiety symptoms measured in kindergarten (age = 6.0 years) and second grade (age = 8.0 years). Early child risk factors (anxiety symptoms and temperament) emerged as the most robust predictor for both parent-and child-reported anxiety outcomes and mediated the effects ...

2011-05-01

352

The Role of Electronegative Impurities in Ozone Generation by High Pressure Discharges  

International Nuclear Information System (INIS)

The high pressure discharges (pulsed or D C corona, barrier, gliding and the others), have been studied both experimentally and theoretically as sources of low temperature plasma for pollution control technologies. The potential of electrical discharge methods has been demonstrated for the decomposition of many types of VOC. The air or oxygen are used as a feed gas in which pollutant is diluted. The ozone production in air or oxygen in such discharges is also discussed

1999-07-11

353

Sustainable managment of the weaner pig through nutrition  

Environmental Research Database

DescriptionIn young pigs the post-weaning period is generally characterised by a marked reduction in voluntary feed intake, poor growth and development, and diarrhoea. The associated reduction in digestive and absorptive capacity of the gastrointestinal tract decreases the overall efficiency of nutrient capture and utilisation, thereby causing an increase in nutrient loading to the environment. The reduction in digestive and absorptive efficiency after weaning has implications for lifetime performance be [continued...

2006-01-31

354

Secondary co-refining of petroleum and coal distillates, and the evaluation of coal cleaning in coal liquefaction  

Energy Technology Data Exchange (ETDEWEB)

This paper describes a research and development project to quantify the effects of cleaning the coal feed on the yield patterns and processing rates for the Liquid Solvent Extraction (LSE) direct coal liquefaction process and to obtain information on the effect of the co-refining of coal-derived and petroleum distillates to premium transport fuels. 6 refs., 25 figs., 40 tabs.

1992-12-31

355

Power Systems Development Facility Gasification Test Run TC07  

Energy Technology Data Exchange (ETDEWEB)

This report discusses Test Campaign TC07 of the Kellogg Brown & Root, Inc. (KBR) Transport Reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using a particulate control device (PCD). The Transport Reactor was operated as a pressurized gasifier during TC07. Prior to TC07, the Transport Reactor was modified to allow operations as an oxygen-blown gasifier. Test Run TC07 was started on December 11, 2001, and the sand circulation tests (TC07A) were completed on December 14, 2001. The coal-feed tests (TC07B-D) were started on January 17, 2002 and completed on April 5, 2002. Due to operational difficulties with the reactor, the unit was taken offline several times. The reactor temperature was varied between ...

2002-04-05

356

Neural classifier construction using regularization, pruning and test error estimation.  

Science.gov (United States)

In this paper we propose a method for construction of feed-forward neural classifiers based on regularization and adaptive architectures. Using a penalized maximum likelihood scheme, we derive a modified form of the entropic error measure and an algebraic estimate of the test error. In conjunction with optimal brain damage pruning, a test error estimate is used to select the network architecture. The scheme is evaluated on four classification problems. PMID:12662736

1998-12-01

357

Metalloporphyrin catalysts for oxygen reduction developed using computer-aided molecular design  

Energy Technology Data Exchange (ETDEWEB)

The objective of this project is the development of a new class of metalloporphyrin materials used as catalsyts for use in fuel cell applications. The metalloporphyrins are excellent candidates for use as catalysts at both the anode and cathode. The catalysts reduce oxygen in 1 M potassium hydroxide, as well as in 2 M sulfuric acid. Covalent attachment to carbon supports is being investigated. The computer-aided molecular design is an iterative process, in which experimental results feed back into the design of future catalysts.

1996-04-01

358

Investigation of pollutant formation of Sweet Sorghum-lignite (Orhaneli) mixtures in fluidised beds  

Energy Technology Data Exchange (ETDEWEB)

Most of the Turkish lignites have undesired fuel properties and they are extremely polluting. In this study, Sweet Sorghum was chosen as the energy plant. Combustion experiments of lignite and lignite-Sweet Sorghum mixtures were carried out in a fluidised bed system. The fuel-feeding ratio was set such that the thermal output of the system remained constant. Addition of Sweet Sorghum to the lignite reduces the pollutant concentration. The results were supported by experimental results.

2004-07-01

359

How does immune challenge inhibit ingestion of palatable food? Evidence that systemic lipopolysaccharide treatment modulates key nodal points of feeding neurocircuitry  

UK PubMed Central (United Kingdom)

Immune challenge induces behavioral changes including reduced ingestion of palatable food. Multiple pathways likely contribute to this effect, including viscerosensory pathways controlling hypothalamic...Full Text Available

2008-11-01

360

Heuristic paradigm: power electricity appliances; Aplicacoes de um paradigma heuristico adaptativo a eletricidade de potencia  

Energy Technology Data Exchange (ETDEWEB)

This paper presents general considerations concerning the application of artificial neural networks algorithms, more specifically the back-propagation learning algorithm and feed-forward multi-layer networks, to several problems in power system. The main application in power systems is the load forecasting, and two solution methods are used to solve it. (author). 45 figs., 32 tabs., 144 refs.

1994-12-31

361

Forests.org: Organizations/Advocacy Links  

Wastenet

...org/ (1 vote) defends the native forest ecosystems and communities of the Southeast United States which are threatened by industrial scale clearcutting to feed chip mills Added: Jan. 20, 2001 | Rate It Don't Buy SFI http://www.dontbuysfi.com/home/ (2 votes) campaign to show the \\

362

Fluidic pumps  

International Nuclear Information System (INIS)

A fluidic pump comprises a two-diode pump having a first displacement vessel, a third diode connected to receive output from the two-diode pump through a delivery line and discharge to an outlet, and a second displacement vessel connected to the delivery line. There is a feed tank at a greater height than the two-diode pump, and a drive unit for alternately pressurising and venting the first and second displacement vessels. The drive pressure required to operate the pump can be of the order of half that for a single stage 2-diode pump. (author).

1988-05-19

363

Effect of wind turbine array establishment at the Overgaard manor on whooper swan; Effekten paa sangsvane ved etablering af en vindmoellepark ved Overgaard gods  

Energy Technology Data Exchange (ETDEWEB)

Whooper swans habitat in the coastal regions of Denmark can be affected by wind turbine arrays on the coast. The planned array consists of 55 wind turbines very close to the swan breeding area. A possibility of moving the swans away from the windmill area would be to spread the preferred swan feeds (rape, potatoes) outside their present breeding ground. (EG) 14 refs.

1998-06-01

364

Effect of feeding and temperature on the circadian rhythms of cortisol, thyroxine and triiodothyronine in pigs  

Energy Technology Data Exchange (ETDEWEB)

An experiment was conducted to evaluate the circadian rhythms of cortisol, thyroxine (T/sub 4/) and triiodothyronine (T/sub 3/) in pigs under two temperature and feeding regimes. Twenty-eight barrows were randomly assigned to one of the following: 1) ad-libitum fed at 5/sup 0/C(AL-5); 2) ad-libitum fed at 20/sup 0/C(AL-20); 3) meal fed at 5/sup 0/C(M-5); and 4) meal fed at 20/sup 0/C(M-20). M-5 and M-20 animals were fed at 0730 and 1400 hrs. Lights were on from 0600 to 2000 hrs. After 5 wks, blood samples were collected for 27 hrs. Serum cortisol, T/sub 4/ and T/sub 3/ concentrations were determined by RIA. No significant differences were found in the mesors, amplitudes or acrophases for cortisol. The mesors for T/sub 4/ (p<.01) were 60.6 +/- 5.6, 40.2 +/- 5.6, 61.2 +/- 5.6 and 49.1 +/- 5.0 ng/ml for AL-5, AL-20, M-5, and M-20, respectively. The mesors for T/sub 3/ (p<.01) were .85 +/- .06, .69 +/- .06, .92 +/- .06 and .66 +/- .05 ng/ml for AL-5, AL-20, M-5, ...

1986-03-05

365

Duck Egg-Drop Syndrome Caused by BYD Virus, a New Tembusu-Related Flavivirus  

UK PubMed Central (United Kingdom)

Since April 2010, a severe outbreak of duck viral infection, with egg drop, feed uptake decline and ovary-oviduct disease, has spread around the major duck-producing regions in China. A new virus, named...Full Text Available

366

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice  

UK PubMed Central (United Kingdom)

Little is known about how diet and energy metabolism interact in determination of lifespan under ad libitum feeding. From 12 weeks of age until death, male and female wild-type (WT) and transgenic (TG)...Full Text Available

2011-02-01

367

Design and fabrication of a traveling-wave muffin-tin accelerating structure at 90 GHz  

Energy Technology Data Exchange (ETDEWEB)

A prototype of a muffin-tin accelerating structure operating at 32 times the SLAC frequency (2.856 GHz) was built for research in high gradient acceleration. A traveling-wave design with single input and output feeds was chosen for the prototype which was fabricated by wire electrodischarge machining. Features of the mechanical design for the prototype are described. Design improvements are presented including considerations of cooling and vacuum.

1997-05-01

368

Conversion of heavy aromatic hydrocarbons to valuable synthetic feed for steamcrackers  

Energy Technology Data Exchange (ETDEWEB)

The scope of the present study was upgrading a set of heavy aromatic hydrocarbons mixtures whose commercial value ranks close to fuel oil and should become even lower in the next future because of the introduction of more stringent regulations on fuels, through hydro-conversion to a synthetic feed for steam-cracking. The resulting process provides an opportunity to improve the economic return of a steamcracking plant, offering the chance of converting low-value mixtures produced by the plant itself, such as fuel oil of cracking (FOK), saving an equivalent amount of naphtha. The method can also be used for converting pyrolysis gasoline (pygas). Although pygas has at present a fair commercial value, it could suffer a significant penalization in the future due to further limitations on total aromatic content in gasoline. Pygas hydro-conversion to a synthetic steam-cracking feedstock has been recently reported. Fractions from refinery, such as heavy distillates (e.g. ...

2007-07-01

369

Cesium ion desorption ionization with Fourier transform mass spectrometry  

International Nuclear Information System (INIS)

Cesium ions (Cs"+) are used for the production of the feed ions necessary to obtain Fourier transform mass spectra (FTMS). The molecule chosen for the initial study of this Cs"+ desorption ionization (DI-FTMS) was vitamin B-12 because of its nonvolatile, thermally labile character. 21 references.

370

A thermal valve heat flux control device  

International Nuclear Information System (INIS)

In order to evacuate the residual power in a nuclear reactor, a thermal valve system is presented for the modification of the heat exchange conditions at the pool exchanger level, which avoids the use of mechanical valves on the pipes. The system involves a vessel containing the exchanger, with openings at the upper end of the vessel and means for feeding the fluid at the lower end, and means for controlling the opening width.

1994-10-05

371

A non-invasive approach for the determination of rumen pH  

Environmental Research Database

DescriptionAt present, measurement of rumen pH for differnt diets and feeding regimes is only possible through direct sampling of the rumen fluid. Such invasive procedures are not practical at the farm level and they have ethical implications for research programmes. This approach also has limitations to its reliability due to spatial variations in acidity within the rumen. Mathematical modelling offers a non-invasive real-time alternative for monitoring rumen pH, and the purpose of the research propose [continued...

2004-01-31

372

A harvesting and handling system for sweet sorghum  

Energy Technology Data Exchange (ETDEWEB)

Total and net energies used harvesting 30-cm billets at 8 t/h were 1 and 0.3 kW x h/t, respectively. Harvested crop had 4% leaves, a 70% mass fraction of billets 30-40 cm long, and a 49/sup 0/ angle of repose. A self-unloading forage wagon with beaters and controls metered billets at 1.5 t/h to feed a juice-expression mill.

1983-12-01

373

Role of Spiral and Multislice Computed Tomography in the evaluation of traumatic and spontaneous oesophageal perforation. Our experience  

International Nuclear Information System (INIS)

Purpose: To assess the role of CT in the evaluation of traumatic and spontaneous oesophageal perforation. Materials and methods: From March 2001 to May 2003, we studied 12 patients (7 males and 5 females; age range: 25-66 years, mean age: 43.5 years) with suspected oesophageal perforation due to motor-vehicle accidents (4 cases), stab wound (one case), post-intubation (2 cases), foreign body ingestion (2 cases) and spontaneous (3 cases). Five patients underwent standard chest and cervical radiography; two patients with suspected foreign body ingestion also underwent a gastrografin swallow study; all of the 12 patients underwent CT of the neck, chest and abdomen before and after intravenous, and in four cases oral, administration of contrast material. Results: In 5 patients with cervical, thoracic and abdominal trauma, the CT examination showed the presence of pleuroparenchymal injury (pneumothorax, pleural effusion and subcutaneous emphysema) as well as findings ...

2005-03-01

374

Waqf in Turkestan: the colonial legacy and the fate of an Islamic institution in early Soviet Central Asia, 1917-1924  

British Library Electronic Table of Contents (United Kingdom)

The paper investigates early Soviet policies regarding the institution of waqf (charitable endowment) in Turkestan, questioning the issue of the post-colonial character of the early Soviet administration. After taking into consideration practices related to waqf management in modern Muslim states and European colonial empires, the paper briefly describes the tsarist administrative approach to the issue. We then address the ambiguity inherent in Soviet policies on waqf requisition and restitution during Civil War years. In the section that follows we deal with different groups of Muslim intellectuals that attempted to use the Soviet state in their mutual struggle over authority in Central Asian society and describe the creation and functioning of the bureaucracies responsible for managing w...

2007-01-01

375

The effect of family processes on school achievement as moderated by socioeconomic context  

British Library Electronic Table of Contents (United Kingdom)

This longitudinal study examined a model of early school achievement in reading and math, as it varies by socioeconomic context, using data from the NICHD Study of Early Child Care and Youth Development. A conceptual model was tested that included features of family stress, early parenting, and school readiness, through both a single-group analysis and also a multiple-group analysis. Latent profile analysis was used to identify subgroups of more advantaged and less advantaged families. Family stress and parenting were shown to operate differently depending on the socioeconomic context, whereas child-based school readiness characteristics were shown to operate similarly across socieodemographic contexts. Implications for intervention are discussed.

2011-01-01

376

Role of Computed Tomography in postoperative diskitis  

International Nuclear Information System (INIS)

Six patients with diskitis following lumbar disk surgery were investigated by Computed Tomography (CT). Four patients underwent CT in a rather early phase of the disease (5-37 days after the onset of the symptoms): a posterior paravertebral fluid collection was always recognized, while the plain film was normal. Later on (2-4 months), the classical signs of diskitis were evident, with both CT and the plain film. The collection was always present at CT. A reintervention, performed on 3 patients, revealed the purulent content of the collections. It seems reasonable to suggest a relationship between the collection and the subsequent diskitis; the collection is probably an early sign of the disease. Its detection is of grat value, because it could allow an immediate and adequate therapy. The authors stress the usefulness of performing CT in an early phase on this kind of symptomatic patients.

1988-01-01

377

Early spondyloarthropathy: scintigraphic, biological, and clinical findings in MRI-positive patients  

British Library Electronic Table of Contents (United Kingdom)

There are no specific diagnostic tests or a gold standard method for measuring disease activity and outcome in spondyloarthropathies (SpA). Many different methods have been developed to assess the signs and symptoms in SpA. The aim of this study was to evaluate the value of scintigraphy, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and Bath Ankilosing Spondylitis Disease Activity Index (BASDAI) in the evaluation of disease activity in early axial SpA diagnosed with magnetic resonance imaging (MRI). Thirty early MRI-positive axial SpA patients (23 males, 7 females) with a median age of 35 (18?55) years and a median duration of inflammatory low back pain of 24 (8?60) months were included in the study. In the patients with sacroiliitis, the sensitivity, specificity, and pos...

2008-01-01

378

Early diagnosis of skeletal disorders in childhood and adolescence by MRI; Fruehdiagnose orthopaedischer Erkrankungen des Kindes- und Jugendalters mit der MRT  

Energy Technology Data Exchange (ETDEWEB)

The early diagnosis of such disorders is of major importance because, in most cases, severe consequences can only be averted by early treatment. The value of magnetic resonance imaging (MRI) in many orthopaedic and traumatological conditions is generally accepted. The value of MRI in this particular field is illustrated by typical case reports on common clinical problems [Deutsch] Der Fruehdiagnose von Erkrankungen des Kindes- und Jugendalters kommt grosse Bedeutung zu, da oftmals nur durch eine daraus resultierende Fruehbehandlung schwerwiegende Folgen vermieden werden koennen. Die Kernspintomographie (Magnetresonanztomographie=MRT) ist in zahlreichen orthopaedischen-traumatologischen Fragestellungen bereits etabliert. An ausgewaehlten Fallbeispielen haeufiger klinischer Problemstellungen soll in der vorliegenden Arbeit der Stellenwert der MRT dargestellt werden. (orig.)

1998-09-18

379

Biomarkers for infants at risk for necrotizing enterocolitis: clues to prevention?  

Science.gov (United States)

Necrotizing enterocolitis (NEC) is the most common severe gastrointestinal emergency that affects premature newborns. This disease often has a rapid onset with few, if any, antecedent signs that can be used to reliably predict its occurrence. Its rapid onset and progression to death, as well as its severe morbidity when the infant survives, begs for early diagnostic tools that may be used in determining those infants who would be at greatest risk for development of the disease and for whom early preventative measures could be targeted. Although studies have suggested efficacy of several techniques such as breath hydrogen, inflammatory mediators in blood, urine or stool, and genetic markers, these all have drawbacks limiting their use. The application of newly developed "omic" approaches may provide biomarkers for early diagnosis and targeted prevention of this disease. PMID:19190533

2009-05-01

380

[Transdermal opioid administration: the pain plaster].  

Science.gov (United States)

A new method of administration of an opioid was recently registered: fentanyl transdermal (brand name: Durogesic), intended particularly for the indication range 'pain in cancer'. Fentanyl is lipid-soluble so that deposition in the skin takes place and the biological half-life is approximately 20 hours after removal of the plaster. It is safe to start on a basis of an equianalgesic conversion of 100:1 in relation to oral morphine, although this may entail some risk of fentanyl under dosage. The dose adjustment time is 12-24 hours before a constant fentanyl level is reached; therefore, after attaching the first sticking plaster, the original morphine dose should be continued for another 12 hours. In addition, the patient may, if necessary, be given supplementary morphine preferably as a short-acting drug. There seems to be no clear indication for transdermal fentanyl either in neuropathic pain or in chronic benign pain. PMID:9221362

1997-04-26

381

Treatment of asymptomatic internal resorption of a maxillary premolar tooth in a military working dog.  

Science.gov (United States)

An asymptomatic pink discoloration of a maxillary right fourth premolar tooth was discovered during a routine oral examination on a 9 year-old Belgian Malinois dog. A radiolucent lesion was seen in the pulpal chamber on radiographic examination. The lesion had perforated the mesiobuccal root of the tooth. The primary differential diagnosis was idiopathic internal resorption. The tooth was treated by partial resection (removal of the mesiobuccal root and associated crown). A vital pulpotomy and amalgam restoration was performed on the remaining tooth structure. A follow-up 1 year later demonstrated a successful treatment outcome. The animal was asymptomatic and able to perform military duties. Clinical and radiographic signs of healing were evident and the tooth was functional. PMID:10518874

1998-12-01

382

The relationship between periodontitis and metabolic syndrome among a Korean nationally representative sample of adults  

British Library Electronic Table of Contents (United Kingdom)

Abstract Aims: The aim of this study was to examine whether metabolic syndrome (MS) is associated with periodontitis in a representative sample of Korean adults, who were involved in the Fourth Korea National Health and Nutrition Examination Survey (KNHANES). Materials and Methods: A total of 7178 subjects over the age of 19 years who participated in KNHANES were examined. MS was defined as the definition proposed by the National Cholesterol Education Program Adult Treatment Panel III and the abdominal obesity cut-off line based on Korean Society for the Study of Obesity. The periodontal status was assessed by the Community Periodontal Index. Multivariate logistic regression analysis was carried out adjusting for the sociodemographics, oral health behaviours and status, and health behaviou...

2011-01-01

383

Tetracycline ulcers of the oesophagus  

Energy Technology Data Exchange (ETDEWEB)

Two cases of tetracycline ulcers of the oesophagus are reported and compared with thirteen other cases from the literature. In most cases, the patients had taken their capsules with little or no fluid just before going to bed. Some hours later they developed retrosternal pain that was intensified by swallowing. Endoscopy showed sharply demarcated greyish-white areas of mucosal damage which represented layers of stratified squamous cells, separated by oedema, and a dense neutrophilic infiltration of the lamina propria and the muscularis mucosa. Roentgenology was unsuitable to detect the lesions. They healed without complications within one to six weeks. Prolonged retention of the capsules in the oesophagus is thought to cause the mucosal damage. Patients on oral tetracycline or doxycycline treatment should therefore be instructed to take their capsules with a meal or with copious water and not just before going to bed.

1981-11-01

384

Tertiary-Butanol: A toxicological review  

British Library Electronic Table of Contents (United Kingdom)

Tert-Butanol is an important intermediate in industrial chemical synthesis, particularly of fuel oxygenates. Human exposure to tert-butanol may occur following fuel oxygenate metabolism or biodegradation. It is poorly absorbed through skin, but is rapidly absorbed upon inhalation or ingestion and distributed to tissues throughout the body. Elimination from blood is slower and the half-life increases with dose. It is largely metabolised by oxidation via 2-methyl-1,2-propanediol to 2-hydroxyisobutyrate, the dominant urinary metabolites. Conjugations also occur and acetone may be found in urine at high doses. The single-dose systemic toxicity of tert-butanol is low, but it is irritant to skin and eyes; high oral doses produce ataxia and hypoactivity and repeated exposure can induce dependence...

2010-01-01

385

Surgical management of osteoradionecrosis of the temporal bone  

Energy Technology Data Exchange (ETDEWEB)

The surgical management of osteoradionecrosis of the temporal bone has met with limited success because of the difficulty in accurate assessment of the viability of nonnecrotic bone intraoperatively. Failure to resect all nonviable bone results in recurrence of a necrotic focus. With the use of hyperbaric oxygen therapy to stabilize marginal bone and oral tetracycline to label viable bone preoperatively, removal of all nonviable bone can be accomplished. Postoperatively, a second course of hyperbaric therapy enhances wound healing, thus assuring a successful outcome. This article details a successful systematic approach that was developed to resect a necrotic focus in the temporal bone of a 10-year-old boy who had undergone a full course of radiotherapy for treatment of a rhabdomyosarcoma.

1988-03-01

386

Studies on Cercariae from Kuwait Bay. X. Description and surface topography of Cercaria kuwaitae X sp. n. (Digenea: Renicolidae).  

Science.gov (United States)

A new renicolid cercaria, Cercaria kuwaitae X sp. n., from the prosobranch gastropod Cerithium scabridum from Kuwait Bay is described. The new cercaria is nonstyleted gymnocephalous with voluminous Y-shaped excretory vesicle, flame cell formula 2[(3 + 3 + 3) + (3 + 3 + 3)] = 36, and without caudal fins. Surface topography of the new cercaria is studied by scanning electron microscopy. Domed papillae are abundant on the anterior and lateral aspects of the body, ciliated papillae are sparse dorsally. The ventral sucker bears nine domed papillae. Domed papillae form two circles around the oral sucker with three circles of spines in between. This is the first renicolid cercaria to be recorded in a gastropod from the Arabian Gulf region. PMID:9789783

1997-12-01

387

Strain differences in the responsiveness between Sprague-Dawley and Fischer rats to nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor  

British Library Electronic Table of Contents (United Kingdom)

To determine a rat strain appropriate for carcinogenicity testing of FYX-051, a xanthine oxidoreductase inhibitor, we performed a 4-week oral toxicity study by administering 0.3, 1 and 3?mg/kg, and 1, 3 and 10?mg/kg of FYX-051 to male Sprague-Dawley (SD) and Fischer (F344) rats, respectively. Histopathology revealed that the degree of FYX-051-induced nephropathy was 3-fold stronger in SD rats than in F344 rats. Our previous study demonstrated that the key factor of species differences in FYX-051-induced nephropathy is purine metabolism. This observation led us to examine the involvement of purine metabolism in differences among two strains of rats. However, purine metabolism was proven not to be implicated as an important factor. Subsequently, other factors responsible for the strain diffe...

2006-01-01

388

Reproductive toxicologic evaluations of Bulbine natalensis Baker stem extract in albino rats  

British Library Electronic Table of Contents (United Kingdom)

The effects of oral administration of aqueous extract of Bulbine natalensis Baker stem at daily doses of 25, 50, and 100mg/kg body weight on the reproductive function of Wistar rats were evaluated. The indices of mating and fertility success as well as quantal frequency increased after 7 days of treatment in all the dose groups except the 100mg/kg body weight group. The number of litters was not statistically different (P>0.05) from the control. Whereas the absolute weights of the epididymis, seminal vesicle, and prostate were not affected, that of the testes was significantly increased. The epididymal sperm count, motility, morphology, and viscosity were not different from the control after 7 days of treatment. The male rat serum testosterone, progesterone, luteinizing hormone, and follic...

2009-01-01

389

Pharmaceutical applications of cyclodextrins: effects on drug permeation through biological membranes  

British Library Electronic Table of Contents (United Kingdom)

Abstract Objectives- Cyclodextrins are useful solubilizing excipients that have gained currency in the formulator's armamentarium based on their ability to temporarily camouflage undesirable physicochemical properties. In this context cyclodextrins can increase oral bioavailability, stabilize compounds to chemical and enzymatic degradation and can affect permeability through biological membranes under certain circumstances. This latter property is examined herein as a function of the published literature as well as work completed in our laboratories. Key findings- Cyclodextrins can increase the uptake of drugs through biological barriers if the limiting barrier component is the unstirred water layer (UWL) that exists between the membrane and bulk water. This means that cyclodextrins are mo...

2011-01-01

390

Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis  

British Library Electronic Table of Contents (United Kingdom)

Knee osteoarthritis (OA) is a common degenerative joint disorder and a major cause of pain and disability. The hypothesis tested in this study was that the passion fruit peel extract (PFP), a flavonoid-rich dietary supplement, would reduce symptoms due to knee OA. Thirty-three OA patients were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. Patients received either placebo or PFP pills (150 mg, daily) in a double-blinded fashion for 2 months. The OA clinical symptoms were evaluated monthly with Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index. In the PFP group, there was a significant improvement in total WOMAC score and WOMAC subscale score of physical function after 30 days and pain after 60 days. At 60 days, reductions o...

2010-01-01

391

Oral administration of purple passion fruit peel extract attenuates blood pressure in female spontaneously hypertensive rats and humans  

British Library Electronic Table of Contents (United Kingdom)

Hypertension is one of the most important modifiable risk factors for cardiovascular and cerebrovascular diseases. We investigated the potential antihypertensive effect of the purple passion fruit peel (PFP) extract, a mixture of bioflavonoids, phenolic acids, and anthocyanins, in spontaneously hypertensive rats and human. A high-performance liquid chromatography analysis was performed to identify the active ingredients of the PFP extract. In a rat liver toxicity assay, no hepatotoxicity was observed after 9 hours incubation in the presence of PFP extract (20 ?g/mL). The PFP extract also revealed hepatoprotection against chloroform (1 mmol/L)-induced liver injury. In the experimental model, 24 spontaneously hypertensive rats were divided into 3 treatment groups for a period of 8weeks: cont...

2007-01-01

392

Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses  

British Library Electronic Table of Contents (United Kingdom)

Although cognitive performance in humans and experimental animals can be improved by administering omega-3 fatty acid docosahexaenoic acid (DHA), the neurochemical mechanisms underlying this effect remain uncertain. In general, nutrients or drugs that modify brain function or behavior do so by affecting synaptic transmission, usually by changing the quantities of particular neurotransmitters present within synaptic clefts or by acting directly on neurotransmitter receptors or signal-transduction molecules. We find that DHA also affects synaptic transmission in mammalian brain. Brain cells of gerbils or rats receiving this fatty acid manifest increased levels of phosphatides and of specific presynaptic or postsynaptic proteins. They also exhibit increased numbers of dendritic spines on post...

2008-01-01

393

Mechanisms involved in the antinociception of petroleum ether fraction from the EtOH extract of Chrysanthemum indicum in mice  

British Library Electronic Table of Contents (United Kingdom)

The petroleum ether fraction (PEF) from the EtOH extract of flowers and buds of Chrysanthemum indicum was evaluated on antinociception in mice using chemical and thermal models of nociception. PEF administered orally at doses of 188 and 376mg/kg produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid, subplantar formalin or capsaicin injections and on thermal nociception in the tail-flick test and the hot plate test. In the pentobarbital sodium-induced sleep time test and the open-field test, PEF neither enhanced the pentobarbital sodium-induced sleep time nor impaired the motor performance, indicating that the observed antinociception was unrelated to sedation or motor abnormality. In a measurement of core body temperature, PEF did not affect temper...

2011-01-01

394

Inhibition of Metabolism of Diethylene Glycol Prevents Target Organ Toxicity in Rats  

British Library Electronic Table of Contents (United Kingdom)

Diethylene glycol (DEG) is an industrial chemical, the misuse of which has led to numerous epidemic poisonings worldwide. The mechanism of its toxicity has not been defined as to the precise relationship between the metabolism of DEG and target organ toxicity. The purpose of this study was to investigate the mechanism for the acute toxicity of DEG, and the effect of the alcohol dehydrogenase inhibitor 4-methylpyrazole (fomepizole), by determining the relationship between accumulation of DEG or its metabolites and the resulting kidney and liver toxicity. Rats were treated by oral gavage with water, 2 g/kg DEG (low dose), 10 g/kg DEG (high dose), or 10 g/kg DEG + fomepizole, and blood and urine were collected over 48 h. Rats treated with high-dose DEG had metabolic acidosis, increased BUN an...

2010-01-01

395

Improving functional esophageal surgery with a ?smart? bougie: endoflip  

British Library Electronic Table of Contents (United Kingdom)

Background An emerging imaging tool, the functional lumen imaging probe (Endoflip; Crospon Ltd, Galway, Ireland), provides a real-time measurement of esophagogastric junction (EGJ) capacity and diameter, which would be of particular interest in functional esophageal surgery such as Heller myotomy and antireflux procedures. This study aimed to demonstrate the intraoperative use of endoflip in the treatment of achalasia and gastroesophageal reflux disease (GERD). Methods In the first case, Heller myotomy was performed under endopflip guidance, for persistent dysphagia after failed endoscopic dilatation. In the second case, the endoflip was used to calibrate a Nissen fundoplication. With the patient under general anesthesia, the endoflip catheter was inserted orally and positioned to straddle...

2011-01-01

396

Human papillomavirus: science and technologies for the elimination of cervical cancer  

British Library Electronic Table of Contents (United Kingdom)

Introduction: Academic research has made a significant advancement in understanding the viral causes of cervical cancer and generating the technology for prevention, both at the primary and secondary levels. Human papillomaviruses (HPVs) have been recognized as the first necessary cause of cervical cancer, the second most common cancer in women worldwide. Areas covered: This paper reviews the epidemiological evidence of the causality of HPV in relation to cervical cancer, other genital tract cancers and some cancers of the oral cavity and oropharynx. The review also covers HPV DNA testing as a screening tool. DNA probes of high-risk HPV types in different formats have been fully validated as primary screening tests, as secondary triage tests and as a prognostic marker following treatment o...

2011-01-01

397

Gallstones: choosing the right therapy despite vague clinical clues.  

Science.gov (United States)

Therapeutic decisions are quite clear-cut for asymptomatic gallstone disease and acute cholecystitis. However, the appropriate therapeutic course for older patients with chronic cholecystitis may be less obvious. Watchful waiting may be reasonable for patients with mild and infrequent symptoms. For healthy patients, cholecystectomy is recommended if symptoms are becoming more frequent and severe. Laparoscopy may reduce the complication rate and be safely performed even in those with underlying medical illness. Oral dissolution therapy can be attempted for qualifying symptomatic patients who are at poor surgical risk or who refuse surgery. Shock wave lithotripsy and contact dissolution therapy show some promise but are currently experimental. PMID:8339941

1993-08-01

398

Experimental study on Satureja montana as a treatment for premature ejaculation  

British Library Electronic Table of Contents (United Kingdom)

Aim of the study: Satureja montana (winter savory) is a medicinal plant traditionally used to treat different disorders including male sexual dysfunction. In this study we evaluated the effect of Satureja montana hydroalcoholic extract on copulatory behavior of sexually potent male rats. Materials and methods: The extract was orally administered acutely or repetitively for 8 consecutive days at the doses of 25 and 50mg/kg. The main parameters of sexual behavior, mount (ML), intromission (IL), ejaculation (EL) latencies and post-ejaculatory interval (PEI), were evaluated in animals submitted to mating test and multiple ejaculations test. Testosterone serum levels were measured in rats acutely treated with Satureja montana extract dosed at 50mg/kg. In addition the open field test was conduct...

2011-01-01

399

Evaluation of the hepatobiliary function with "9"9"mTc-EHIDA imaging during total parenteral nutrition  

International Nuclear Information System (INIS)

14 surgical patients with non-hepatobiliary diseases were studied with "9"9"mTc-EHIDA imaging to evaluate the effect of total parenteral nutrition (TPN) on the hepatobiliary function. Duration of TPN ranged from 6-56 days, 10 of the 14 patients Beijing within 10 days. The results showed that: (1) 11 of 14 patients had abnormal scintigraphic features. The most prominet findings were delayed liver excretion and prolonged blood clearance time. This fact suggests that not only the rate of excretion of the bile from the liver is decreased but the uptake ability of the hepatorcyte is also impaired. (2) The effect of TPN on liver function is reversible. It was concluded that in order to prevent irreversible damage of hepatobiliary function caused by TPN, the duration of TPN should not be too long and oral intake of nutrients should be resumed as soon as possible.

400

Efficacy, tolerability, and safety of risedronate in Japanese patients with Paget?s disease of bone  

British Library Electronic Table of Contents (United Kingdom)

This study evaluated the clinical efficacy of treatment with oral risedronate (17.5?mg once daily) for 8?weeks in 11 Japanese patients with Paget?s disease of bone (PDB). Risedronate suppressed the excessive bone turnover associated with PDB and improved several biochemical markers, including serum alkaline phosphatase (ALP), serum bone-specific ALP (BALP), urinary deoxypyridinoline (DPD), and urinary cross-linked N-telopeptide of type 1 collagen (NTX). These markers began to decrease within about 2?weeks after the initiation of treatment in most patients, and the response persisted for up to 40?weeks after the cessation of treatment. Risedronate reduced pain by week 24 in most patients. According to quantitative bone scintigraphy, the lesion with the highest radioisotope (RI) uptake showe...

2010-01-01

401

Effects of swimming training at the intensity equivalent to aerobic/anaerobic metabolic transition in alloxan diabetic rats  

British Library Electronic Table of Contents (United Kingdom)

The present study was designed to determine the exercise intensity equivalent to the metabolic aerobic/anaerobic transition of alloxan diabetic rats, through lactate minimum test (LMT), and to evaluate the effects of swimming exercise at this intensity (LM) on the glucose and protein metabolism of these animals. Adult male Wistar rats received alloxan (SD, alloxan-injected rats that remained sedentary) intravenously (30 mg kg?1 body weight) for diabetes induction. As controls (SC, vehicle-injected rats that remained sedentary), vehicle-injected rats were utilized. Two weeks later, the animals were submitted to oral glucose tolerance test (oGTT) and LMT. After the tests, some of the animals were submitted to swimming exercise training [TC (vehicle-injected rats that performed a 6-week exerc...

2007-01-01

402

Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments  

British Library Electronic Table of Contents (United Kingdom)

Ethnopharmacological relevance: Extracts of the roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used to relieve fever related to bacterial infection and inflammatory diseases in traditional Korean medicine and have been reported to be effective in brain diseases. These experiments were conducted to examine the effects of oral administration of Scutellaria baicalensis extracts on the rescue of memory impairments induced by chronic cerebral hypoperfusion or chronic lipopolysaccharide (LPS) infusion. In addition, the underlying mechanisms of these effects were investigated. Materials and methods: In the first experiment, chronic cerebral hypoperfusion was induced in male Wister rats by bilateral common carotid artery occlusion (BCCAo). Daily administration of Scutellaria b...

2011-01-01

403

Diphtheria toxoid conformation in the context of its nanoencapsulation within liposomal particles sandwiched by chitosan  

British Library Electronic Table of Contents (United Kingdom)

Chitosan (a?-(1-4)-amino-2-deoxy-b?-D-glucan) is a deacetylated form of chitin, a polysaccharide from crustacean shells. Its unique characteristics, such as positive charge, biodegradability, biocompatibility, nontoxicity, and rigid structure, make this macromolecule ideal for an oral vaccine delivery system. We prepared reverse-phase evaporation vesicles (REVs) sandwiched by chitosan (Chi) and polyvinylic alcohol (PVA). However, in this method, there are still some problems to be circumvented related to protein stabilization. During the inverted micelle phase of protein nanoencapsulation, hydrophobic interfaces are expanded, leading to interfacial adsorption, followed by protein unfolding and aggregation. Here, spectroscopic and immunological techniques were used to ascertain the effects ...

2011-01-01

404

Combined bony closure of oroantral fistula and sinus lift with mandibular bone grafts for subsequent dental implant placement  

British Library Electronic Table of Contents (United Kingdom)

Sinus lifting and reconstruction of localized alveolar defects are often required after closure of a large oroantral fistula (OAF) to allow for subsequent implant installation. This study describes a combined surgical technique that involves sinus lifting, bony closure, and reconstruction of the alveolar defect at the site of an OAF. The sinus membrane was reconstructed as a continuous layer by combining the residual sinus membrane with a rotated part of oral mucosa around the OAF. Autogenous bone from the chin and/or ramus was grafted into the prepared sinus space and alveolar defect, and the graft was covered by a buccal advancement flap. This technique was used to treat 8 patients who had large OAFs in the posterior maxillary region. The treatment was successful in all cases, and the te...

2011-01-01

405

Cancer-cell-specific cytotoxicity of non-oxidized iron elements in iron core-gold shell NPs  

British Library Electronic Table of Contents (United Kingdom)

Gold-coated iron nanoparticles (NPs) selectively and significantly (P <0.0001) inhibit proliferation of oral- and colorectal-cancer cells in vitro at doses as low as 5 mg/mL, but have little adverse effect on normal healthy control cells. The particle treatment caused delay in cell-cycle progression, especially in the S-phase. There was no significant difference in the NP uptake between cancer and control cells, and cytotoxicity resulted primarily from the iron core, before oxidation, rather than from the Fe ions released from the core. In contrast with magnetic NPs that usually serve as drug carriers, diagnostic probes or hyperthermia media, the iron, before oxidation, in the NPs selectively suppressed cancer cell growth and left healthy control cells unaffected in vitro and in vivo. This...

2011-01-01

406

Antibacterial iridoid glucosides from Eremostachys laciniata  

British Library Electronic Table of Contents (United Kingdom)

Eremostachys laciniata (L) Bunge (family: Lamiaceae alt. Labiatae; subfamily: Lamioideae) is one of the 15 endemic Iranian herbs of the genus Eremostachys. A decoction of the roots and flowers of E. laciniata has traditionally been taken orally for the treatment of allergies, headache and liver diseases. Three antibacterial iridoid glucosides, phloyoside I (1), phlomiol (2) and pulchelloside I (3) have been isolated from the rhizomes of this plant. The structures of these compounds were elucidated unequivocally by a series of 1D and 2D NMR analyses. The antibacterial activity and brine shrimp toxicity of these compounds were assessed using the resazurin microtitre assay and the brine shrimp lethality assay, respectively. All three iridoid glycosides 1-3 exhibited from low to moderate level...

2009-01-01

407

Ambulatory open Bankart repair under a single general anesthesia: A prospective study of the immediate outcome  

British Library Electronic Table of Contents (United Kingdom)

The interscalenic block technique is widely used for ambulatory shoulder surgery despite a substantial number of failures and adverse effects. We prospectively evaluated satisfaction in 40 consecutive patients who underwent open Bankart repair under a single general anesthesic performed in an ambulatory care unit. The mean age of the patients was 23 years. There were 29 men and 11 women. Patients were evaluated postoperatively with a visual analog scale of pain (in the recovery room, at the time of discharge, and the day after and 1 week after surgery) via a home assessment questionnaire that included the following: effectiveness of oral pain medication, ability to perform activities of daily life, and overall satisfaction. One patient failed to be discharged because of a feeling of faintn...

2006-01-01

408

A phase II trial of sorafenib in first-line metastatic urothelial cancer: a study of the PMH Phase II Consortium  

British Library Electronic Table of Contents (United Kingdom)

Summary Background Sorafenib is an oral multikinase inhibitor that blocks cell proliferation via the ERK pathway and angiogenesis via the VEGF pathway. This phase II trial was conducted to determine the efficacy and tolerability of sorafenib for the treatment of patients with metastatic urothelial cancer (UC) who had not had prior chemotherapy for advanced disease. Patients and Methods Seventeen chemo-na?ve UC patients with adequate performance status and organ function were treated with sorafenib 400?mg twice daily on a continuous basis until progression or unacceptable toxicity. The primary endpoint was objective tumor response rate as measured by RECIST criteria. Secondary endpoints included rate of prolonged stable disease (>3?months), time to progression, median and 1?yr survival and ...

2011-01-01

409

A 24-week, multicentre, open evaluation of the clinical effectiveness of the rivastigmine patch in patients with probable Alzheimer-s disease  

British Library Electronic Table of Contents (United Kingdom)

Summary Background:- Cholinesterase inhibitors form the mainstay of treatment for persons with mild-to-moderate Alzheimer-s disease (AD). The rivastigmine patch may increase compliance and the proportion of patients maintaining an efficacious dose compared with oral cholinesterase inhibitors. Objective:- To investigate the proportion of patients who reached and maintained the target rivastigmine patch dose compared with the target rivastigmine capsule dose reported in clinical trials. Methods:- This was a multicentre, 24-week, open-label study in persons with probable AD and a Mini-Mental State Examination (MMSE) score of --10 and --26. The primary outcome was the proportion of patients (ITT population) treated with 9.5-mg/24-h rivastigmine patch for at least 8-weeks at week 24. Secondary ...

2011-01-01

410

Tumor-Endothelial Interaction Links the CD44+/CD24- Phenotype with Poor Prognosis in Early-Stage Breast Cancer1  

UK PubMed Central (United Kingdom)

Materials and MethodsThe genomic effects of tumor-endothelial interactions in cancer are not yet well characterized. To study this interaction in breast...Full Text Available

2009-10-01

411

Tumor Necrosis Factor-? and Muc2 Mucin Play Major Roles in Disease Onset and Progression in Dextran Sodium Sulphate-Induced Colitis  

UK PubMed Central (United Kingdom)

The sequential events and the inflammatory mediators that characterize disease onset and progression of ulcerative colitis (UC) are not well known. In this study, we evaluated the early pathologic events...Full Text Available

412

Trial of early nifedipine in acute myocardial infarction: the Trent study.  

UK PubMed Central (United Kingdom)

Over 30 months 9292 consecutive patients admitted to nine coronary care units with suspected myocardial infarction were considered for admission to a randomised double blind study comparing the effect...Full Text Available

1986-11-08

413

Treatment of early uterine sarcomas: disentangling adjuvant modalities  

UK PubMed Central (United Kingdom)

Uterine sarcomas are a rare group of neoplasms with aggressive clinical course and poor prognosis. They are classified into four main histological subtypes in order of decreasing incidence: carcinosarcomas,...Full Text Available

414

Transport of Purine and Pyrimidine Bases and Nucleosides from Endosperm to Cotyledons in Germinating Castor Bean Seedlings 1  

UK PubMed Central (United Kingdom)

During germination and early growth of castor bean (Ricinus communis), all cellular constituents of the endosperm are eventually transferred to the growing embryo. The present results...Full Text Available

1983-10-01

415

Transmitted drug resistance in nonsubtype B HIV-1 infection  

UK PubMed Central (United Kingdom)

HIV-1 nonsubtype B variants account for the majority of HIV infections worldwide. Drug resistance in individuals who have never undergone antiretroviral therapy can lead to early failure and...Full Text Available

2009-09-01

416

Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning  

UK PubMed Central (United Kingdom)

Memory consolidation requires transcription and translation of new protein. Arc, an effector immediate early gene, and zif268, a regulatory transcription factor, have been implicated in synaptic plasticity...Full Text Available

2010-01-01

417

Surveillance for the detection of early lung cancer in patients with bronchial dysplasia  

UK PubMed Central (United Kingdom)

BackgroundThe natural history of bronchial preinvasive lesions and the risk of developing lung cancer in patients with these lesions are not clear. Previous studies have treated...Full Text Available

2007-01-01

418

Superheavy elements - the quest in perspective  

International Nuclear Information System (INIS)

A review is presented of the quest for superheavy elements under the following headings - early history; physical and nuclear properties unique to superheavy elements; searches in nature; terrestrial samples; extra-terrestrial samples; and searches at accelerators. 72 references. (U.K.).

419

Stopping or Reporting Early for Positive Results in Randomized Clinical Trials: The National Cancer Institute Cooperative Group Experience From 1990 to 2005  

UK PubMed Central (United Kingdom)

Randomized clinical trials are designed with stopping boundaries to guide data monitoring committees with their decision making concerning ongoing trials. In particular, when extremely positive results...Full Text Available

2009-04-01

420

Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs)  

UK PubMed Central (United Kingdom)

Early on, intriguing biological activities were found associated with the EETs using in vitro systems. Although the EETs other than the 5,6-isomer, are quite stable chemically,...Full Text Available

2007-01-01

421

Social Deficits, Stereotypy, and Early Emergence of Repetitive Behavior in the C58/J Inbred Mouse Strain  

UK PubMed Central (United Kingdom)

Mouse lines with behavioral phenotypes relevant to symptoms in neurodevelopmental disorders may provide models to test hypotheses about disease etiology and to evaluate potential treatments....Full Text Available

2010-03-17

422

Smoking and Illicit Drug Use Associations With Early Versus Delayed Reproduction: Findings in a Young Adult Cohort of Australian Twins*  

UK PubMed Central (United Kingdom)

Objective:This article examines relationships between reproductive onset and lifetime history of smoking, regular smoking, and nicotine dependence, and cannabis and other illicit...Full Text Available

2009-09-01

423

Site specific effects of anosmia and cloacal gland anesthesia on Fos expression induced in male quail brain by sexual behavior  

UK PubMed Central (United Kingdom)

In rats, expression of the immediate early gene, c-fos observed in the brain following male copulatory behavior relates mostly to the detection of olfactory information originating...Full Text Available

2008-12-01

424

Shielding of Sleeping Beauty DNA Transposon-delivered Transgene Cassettes by Heterologous Insulators in Early Embryonal Cells  

UK PubMed Central (United Kingdom)

The Sleeping Beauty (SB) transposon system represents an important alternative to viral integrating vector systems but may, as its viral counterparts, be subject to transcriptional silencing. To investigate...Full Text Available

2009-01-01

425

Shedding New Light on Early Caries Detection  

UK PubMed Central (United Kingdom)

Dental caries continues to be a common chronic disease among various population groups. Patient care can be improved with detection at the earliest stage. However, current techniques do not...Full Text Available

2008-12-01

426

SG Report on Harmony with Nature final single-spaced.doc  

Wastenet

of early humanitarians, and the vivisectors turned to Rene Descartes (1596 1650 ) to justify ...A celebrated mathematician, physiologist, and psychologist, Descartes provided a general philosophy of the irrelevance of ethics to the ...Animals, according to Descartes, were insensible and irrational machines; moved, like clocks, but

427

Risedronate Prevents Early Radiation-Induced Osteoporosis in Mice at Multiple Skeletal Locations  

UK PubMed Central (United Kingdom)

IntroductionIrradiation of normal, non-malignant bone during cancer therapy can lead to atrophy and increased risk of fracture at several skeletal sites, particularly...Full Text Available

2010-01-01

428

Release of oxytocin and prolactin in response to suckling.  

UK PubMed Central (United Kingdom)

The oxytocin and prolactin responses to suckling were measured in 10 women in early (n = 5) and established lactation (n = 5). Oxytocin was released in a pulsatile manner during suckling in all women,...Full Text Available

1983-01-22

429

Rapid isolation and identification of group B streptococci from selective broth medium by slide co-agglutination test.  

UK PubMed Central (United Kingdom)

Direct identification of group B streptococci from a selective broth medium was performed with the Phadebact streptococcus test to determine the feasibility of this technique for early detection of...Full Text Available

1978-10-01

430

RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3  

UK PubMed Central (United Kingdom)

Totipotent stem cells have the potential to differentiate into every cell type. Renewal of totipotent stem cells in the germline and cellular differentiation during early embryogenesis rely upon posttranscriptional...Full Text Available

2009-12-01

431

Putative Biomarkers and Targets of Estrogen Receptor Negative Human Breast Cancer  

UK PubMed Central (United Kingdom)

Breast cancer is a progressive and potentially fatal disease that affects women of all ages. Like all progressive diseases, early and reliable diagnosis is the key for successful treatment and annihilation....Full Text Available

432

Proteomic patterns analysis with multivariate calculations as a promising tool for prompt differentiation of early stage lung tissue with cancer and unchanged tissue material  

UK PubMed Central (United Kingdom)

BackgroundLung cancer diagnosis in tissue material with commonly used histological techniques is sometimes inconvenient and in a number of cases leads to ambiguous conclusions. Frequently...Full Text Available

433

Prostaglandin-induced Abortion: Assessment of Operative Complications and Early Morbidity  

UK PubMed Central (United Kingdom)

A total of 626 patients undergoing a prostaglandin-induced abortion, the majority in the second trimester, have been analysed for complications occurring during inpatient treatment. Of the last 155...Full Text Available

1974-12-21

434

Propranolol ameliorates the development of portal-systemic shunting in a chronic murine schistosomiasis model of portal hypertension.  

UK PubMed Central (United Kingdom)

We investigated the role of early portal hypotensive pharmacotherapy in preventing the development of portal-systemic shunting in a portal hypertensive model of chronic murine schistosomiasis induced...Full Text Available

1991-03-01

435

Progressive Management of Open Surgical Repair of Achilles Tendon Rupture  

UK PubMed Central (United Kingdom)

A 33-year-old man sustained an acute Achilles tendon rupture which was surgically repaired. Early nonweight-bearing range of motion and strengthening of the ankle and the repaired muscle unit was allowed...Full Text Available

1994-12-01

436

Prognostic significance of neutropenia during adjuvant concurrent chemoradiotherapy in early cervical cancer  

UK PubMed Central (United Kingdom)

ObjectiveTo evaluate the prognostic significance of adjuvant concurrent chemoradiotherapy-induced neutropenia with survival in patients with squamous cell carcinoma of the uterine...Full Text Available

2009-09-01

437

Prognostic Significance of Peritumoral Lymphatic Vessel Density and Vascular Endothelial Growth Factor Receptor 3 in Invasive Squamous Cell Cervical Cancer  

UK PubMed Central (United Kingdom)

Cervical cancer is known to metastasize primarily by the lymphatic system. Dissemination through lymphatic vessels represents an early step in regional tumor progression, and the presence of lymphatic...Full Text Available

438

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety  

UK PubMed Central (United Kingdom)

Preterm birth is the leading cause of neonatal mortality and morbidity and long-term disability of non-anomalous infants. Previous studies have identified a prior early spontaneous preterm birth as...Full Text Available

2009-01-01

439

Predictivity of survival according to different equations for estimating renal function in community-dwelling elderly subjects  

UK PubMed Central (United Kingdom)

Background. Detection of subjects with early chronic kidney disease (CKD) is important because some will progress up to stage 5 CKD, and most are at high risk of cardiovascular morbidity...Full Text Available

2009-04-01

440

Photochemical injury to the foveomacula of the monkey eye following argon blue-green panretinal photocoagulation.  

UK PubMed Central (United Kingdom)

PURPOSE: Visual loss following panretinal photocoagulation was found in the Diabetic Retinopathy and the Early Treatment Diabetic Retinopathy Studies. This study was designed to test the hypothesis...Full Text Available

2000-01-01

441

Personalized healthcare in clotting disorders  

UK PubMed Central (United Kingdom)

In terms of managing thrombotic disorders, genotype-based individualized patient care emerged as early as 1994 when the association of factor V Leiden (G1691A), and later, prothrombin (G20210A),...Full Text Available

2010-01-01

442

Percutaneous mitral valve repair: the beginning of the end or the end of the beginning?  

UK PubMed Central (United Kingdom)

The new percutaneous mitral valve repair techniques are at an early stage. Preliminary series show that they are feasible; however, they need to be further evaluated in comparison with contemporary...Full Text Available

443

Outcome of early surgery after coronary angioplasty.  

UK PubMed Central (United Kingdom)

Nineteen of 69 patients undergoing coronary angioplasty required immediate coronary surgery after the procedure. Six of these operations were planned as a result of angioplasty that failed without producing...Full Text Available

1986-03-01

444

Novel Pathologic Findings Associated with Urinary Retention in a Mouse Model of Mucopolysaccharidosis Type IIIB  

UK PubMed Central (United Kingdom)

Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome type B) is a metabolic disorder with devastating clinical characteristics starting in early childhood and leading to premature death. A...Full Text Available

2009-04-01

445

Neoangiogenesis in early cervical cancer: Correlation between color Doppler findings and risk factors. A prospective observational study  

UK PubMed Central (United Kingdom)

BackgroundThe aim of the present article was to evaluate whether angiogenic parameters as assessed by transvaginal color Doppler ultrasound (TVCD) may predict those prognostic factors...Full Text Available

447

Mutant ?-Synuclein Overexpression Mediates Early Proinflammatory Activity  

UK PubMed Central (United Kingdom)

Microglia provide immune surveillance for the brain through both the removal of cellular debris and protection against infection by microorganisms and “foreign” molecules. Upon...Full Text Available

2009-10-01

448

Metagenes Associated with Survival in Non-Small Cell Lung Cancer  

UK PubMed Central (United Kingdom)

NSCLC (non-small cell lung cancer) comprises about 80% of all lung cancer cases worldwide. Surgery is most effective treatment for patients with early-stage disease. However, 30%–55% of these...Full Text Available

449

Metabolic syndrome in subjects with type-2 diabetes mellitus.  

UK PubMed Central (United Kingdom)

BACKGROUND: Each component of metabolic syndrome (MS) conveys increased cardiovascular disease risk, but as a combination they become much more powerful. Vigorous early management of the syndrome may...Full Text Available

2004-06-01

450

Maternal Obesity Induced by Diet in Rats Permanently Influences Central Processes Regulating Food Intake in Offspring  

UK PubMed Central (United Kingdom)

Hypothalamic systems which regulate appetite may be permanently modified during early development. We have previously reported hyperphagia and increased adiposity in the adult offspring of rodents fed...Full Text Available

451

Management of the early and late presentations of rheumatoid arthritis: a survey of Ontario primary care physicians.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To examine primary care physicians' management of rheumatoid arthritis, ascertain the determinants of management and compare management with that recommended by a current practice panel....Full Text Available

1996-09-15

452

Localisation of glycoproteins and glycosaminoglycans during early eye development in the macaque.  

UK PubMed Central (United Kingdom)

The composition of the extracellular matrix (ECM) was examined in the developing lens and optic cup (stages 11-16) of the long-tailed monkey (Macaca fascicularis) using peroxidase immunocytochemistry....Full Text Available

1995-02-01

453

Influence of microenvironment on engraftment of transplanted ?-cells  

UK PubMed Central (United Kingdom)

Pancreatic islet transplantation into the liver provides a possibility to treat selected patients with brittle type 1 diabetes mellitus. However, massive early β-cell death increases the number...Full Text Available

2011-02-01

454

Indian vaccine innovation: the case of Shantha Biotechnics  

UK PubMed Central (United Kingdom)

BackgroundAlthough the World Health Organization had recommended that every child be vaccinated for Hepatitis B by the early 1980s, large multinational pharmaceutical companies held...Full Text Available

455

Importance of eelgrass early life history stages in response to oyster aquaculture disturbance  

Science.gov (United States)

Aquaculture is increasing worldwide, however we have little understanding of its impacts on marine communities. A critical element of many marine communities are seagrasses, a group of globally distributed marine angiosperms that are drivers of many abiotic and biotic processes in estuarine and mari...

456

Impaired Perinatal Growth and Longevity: A Life History Perspective  

UK PubMed Central (United Kingdom)

Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual phenotype...Full Text Available

2009-01-01

457

Immune activation and IL-12 production during acute/early HIV infection in the absence and presence of highly active, antiretroviral therapy  

UK PubMed Central (United Kingdom)

Suppressed IL-12 production and maladaptive immune activation, both of which are ameliorated by successful highly active antiretroviral therapy (HAART), are thought to play important roles in the immunopathogenesis...Full Text Available

2008-12-01

458

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice  

UK PubMed Central (United Kingdom)

Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level. Metformin increases lifespan and prevents cancer...Full Text Available

459

Heart Rate Characteristics: Physiomarkers for Detection of Late-Onset Neonatal Sepsis  

UK PubMed Central (United Kingdom)

SynopsisEarly detection of late onset neonatal sepsis, prior to obvious and potentially catastrophic clinical signs, is an important goal in neonatal medicine. Sepsis causes a...Full Text Available

2010-09-01

460

Genetics and molecular pathology of Stargardt-like macular degeneration  

UK PubMed Central (United Kingdom)

Stargardt-like macular degeneration (STGD3) is an early onset, autosomal dominant macular degeneration. STGD3 is characterized by a progressive pathology, the loss of central vision, atrophy...Full Text Available

2010-05-01

461

Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse  

UK PubMed Central (United Kingdom)

BackgroundRecessive mutations in guanylate cyclase-1 (Gucy2d) are associated with severe, early onset Leber congenital amaurosis-1(LCA1). Gucy2d...Full Text Available

462

Formation and evolution of the protoplanetary disk  

International Nuclear Information System (INIS)

A disk formation model during collapse of the protosolar nebula, yielding a low-mass protoplanetary disk is presented. The following subject areas are covered: (1) circumstellar disks; (2) conditions for the formation of stars with disks; (3) early evolution of the protoplanetary disk; and (4) temperature conditions and the convection in the protoplanetary disk.

1989-01-02

463

Factors Affecting Daughter Cells' Arrangement during the Early Bacterial Divisions  

UK PubMed Central (United Kingdom)

On agar plates, daughter cells of Escherichia coli mutually slide and align side-by-side in parallel during the first round of binary fission. This phenomenon has been previously attributed...Full Text Available

464

Evolution of age at menarche and at onset of regular cycling in a large cohort of French women  

UK PubMed Central (United Kingdom)

BackgroundEarly exposure to ovarian hormones is considered to increase breast cancer incidence. The age at which the ovaries become functional is thus important.Full Text Available

2002-01-01

465

Evidence from ammonoids and conodonts for multiple Early Triassic mass extinctions  

UK PubMed Central (United Kingdom)

Ammonoids and conodonts, being characterized by exceptionally high background rates of origination and extinction, were vulnerable to global environmental crises, which characteristically intensified...Full Text Available

2009-09-08

466

Establishment and expression of cellular polarity in fucoid zygotes.  

UK PubMed Central (United Kingdom)

Zygotes of fucoid algae have long been studied as a paradigm for cell polarity. Polarity is established early in the first cell cycle and is then expressed as localized growth and invariant cell division....Full Text Available

1992-06-01

467

Elk-1 a Transcription Factor with Multiple Facets in the Brain  

UK PubMed Central (United Kingdom)

The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site. Elk-1 is associated with...Full Text Available

468

Effect of early bursectomy on germinal centre and immunoglobulin production in chickens.  

UK PubMed Central (United Kingdom)

Chickens were bursectomized in ovo on days 18, 19 or 20 of incubation or within 6 h of hatch and immunized at day 28 after hatch by an intravenous injection of sheep red blood cells (SRBC). The immune...Full Text Available

1977-11-01

469

Early inflammatory markers in elicitation of allergic contact dermatitis  

UK PubMed Central (United Kingdom)

BackgroundAllergic Contact Dermatitis (ACD) is regarded as a T-cell-mediated delayed-type hypersensitivity reaction. We studied the kinetics of the expression of CS-1 fibronectin,...Full Text Available

470

Early effects of boron neutron capture therapy on rat glioma models  

International Nuclear Information System (INIS)

Early effects of boron neutron capture therapy (BNCT) on malignant glioma are characterized by reduction of the enhancement area and regression of the peritumoral edema radiologically. The aim of this study was to investigate the early histological changes of tumors and inflammatory cells after BNCT in the rat brain. Rats were treated with BNCT using boronophenylalanine (BPA) 7 days after implantation of C6 glioma cells. The tumors were assessed with magnetic resonance imaging and histopathological examination at 4 days after BNCT. The mean tumor volumes were 39#+-#2 mm"3 in the BNCT group and 134#+-#18 mm"3 in the control group. In the BNCT group, tumor cells showed a less pleomorphic appearance with atypical nuclei and mitotic figures. The Ki-67 labeling index was 6.5%#+-#4.7% in the BNCT and 35%#+-#3.8% in the control group. The reactions of the inflammatory cells were examined with ED-1 as macrophage marker and OX42 as microglia marker. ...

471

Early detection of bone metastases of Ewing's sarcoma by magnetic resonance imaging  

International Nuclear Information System (INIS)

Bone metastases of an Ewing's sarcoma were detected by magnetic resonance imaging (MRI), when bone scan, CT and plain films were still normal. This is due to the ability of MRI to detect intramedullary metastases before involvement of the cortex. (Auth.).

472

Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes  

UK PubMed Central (United Kingdom)

IntroductionRadiotherapy outcomes might be further improved by a greater understanding of the individual variations in normal tissue reactions that determine tolerance. Most published...Full Text Available

2005-01-01

473

Early Time Structuring of VHANES: Preliminary Results  

Science.gov (United States)

... (Starfish), we note that Qi - Qio(VdO/VAa)(l + R /RM3 )- which is based on ... OCY ATTN R. JEFFRIES KENNETH SW CHAMPION OCY ATTN J. ZINN ...

1990-08-15

474

Early Post-operative Periprosthetic Femur Fracture in the Presence of a Non-cemented Tapered Wedge Femoral Stem  

UK PubMed Central (United Kingdom)

Non-cemented femoral fixation in hip arthroplasty has become the standard of practice in the USA. However, recent literature has brought attention to an increasing incidence of periprosthetic femur...Full Text Available

2010-09-01

475

Early Experience in the Treatment of Intra-Cranial Aneurysms by Endovascular Flow Diversion: A Multicentre Prospective Study  

UK PubMed Central (United Kingdom)

IntroductionFlow diversion is a new approach to the endovascular treatment of intracranial aneurysms which uses a high density mesh stent to induce sac thrombosis. These devices...Full Text Available

476

Early Detection of Bronchial Lesions Using Lung Imaging Fluorescence Endoscope  

UK PubMed Central (United Kingdom)

The performance of the Lung Imaging Fluorescence Endoscope (LIFE) system was compared with conventional bronchoscopy in 158 patients: 68 patients with invasive cancer, 42 patients with abnormal sputum...Full Text Available

1999-01-01

477

Early Changes in Bone Specific Turnover Markers During the Healing Process After Vertebral Fracture  

UK PubMed Central (United Kingdom)

Background:The present study measured longitudinal changes in bone turnover markers in elderly patients with vertebral fracture and investigated the relationship among bone turnover...Full Text Available

478

Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials  

UK PubMed Central (United Kingdom)

A paradoxical metabolic imbalance in inorganic phosphate occurs from the early onset of diabetes and may lead to a reduction of high energy phosphates and tissue hypoxia. These changes take place in...Full Text Available

479

Diagnosis of Ewing's sarcoma in the thoracic spine - problems in differential diagnosis  

International Nuclear Information System (INIS)

Spinal Ewing's sarcomas are rare and cause problems in differential diagnosis. The radiologic, nuclear medicine and CT findings in two children with histologically proven Ewing's sarcoma are presented and problems in differential diagnosis discussed. Biopsy should be done early. (orig.).

480

Cost analysis of a project to digitize classic articles in neurosurgery*  

UK PubMed Central (United Kingdom)

In summer 2000, the Cushing/Whitney Medical Library at Yale University began a demonstration project to digitize classic articles in neurosurgery from the late 1800s and early 1900s. The objective of...Full Text Available

2002-04-01

481

Control of Apple Ripening by Succinic Acid 2,2-Dimethyl Hydrazide, 2-Chloroethyltrimethylammonium Chloride, and Ethylene 1  

UK PubMed Central (United Kingdom)

Ripening of `Tydeman's Early' apples (Malus sylvestris L.) assessed by the occurrence of the respiratory climacteric was delayed by succinic acid 2,2-dimethyl hydrazide (B-9) but not...Full Text Available

1969-08-01

482

Colorectal Cancer Association of Canada consensus meeting: raising the standards of care for early-stage rectal cancer  

UK PubMed Central (United Kingdom)

The purpose of the meeting reported here was to develop a set of national evidence-based standards for assessing and managing patients with potentially resectable rectal cancer. This report represents...Full Text Available

2009-12-01

483

Clinical review: Patency of the circuit in continuous renal replacement therapy  

UK PubMed Central (United Kingdom)

Premature circuit clotting is a major problem in daily practice of continuous renal replacement therapy (CRRT), increasing blood loss, workload, and costs. Early clotting is related to bioincompatibility,...Full Text Available

2007-01-01

484

Characteristics of early- and late-recruited oxytocin bursting cells at the beginning of suckling in rats.  

UK PubMed Central (United Kingdom)

1. Paired or single recordings of paraventricular and/or supraoptic oxytocin cells at the beginning of suckling in urethane-anaesthetized rats enabled us to study cell recruitment and compare the characteristics...Full Text Available

1988-05-01

485

Cerebral scintigraphy--the phoenix rises again.  

UK PubMed Central (United Kingdom)

This paper reviews the development of cerebral scintigraphy from its early days of planar imaging with simple technetium-99m labelled compounds to the recent revival of the technique in the form of...Full Text Available

1988-01-01

486

Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound  

UK PubMed Central (United Kingdom)

Fish living in contaminated environments accumulate toxic chemicals in their tissues. Biomarkers are needed to identify the resulting health effects, particularly focusing on early changes at a subcellular...Full Text Available

2006-06-01

487

Be stars  

Energy Technology Data Exchange (ETDEWEB)

Research on Be stars from the early work of Merrill and Struve to the present is reviewed, including recent observations from space. A number of models which have been proposed to explain the Be phenomenon are discussed, and the evolutionary status of Be stars is considered. 126 references.

1988-07-01

488

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography  

UK PubMed Central (United Kingdom)

BackgroundIn vitro data suggest that changes in myocardial substrate metabolism may contribute to impaired myocardial function in diabetic cardiomyopathy (DCM)....Full Text Available

489

Age at the onset of senescence in birds and mammals is predicted by early-life performance  

UK PubMed Central (United Kingdom)

Life-history theory predicts that traits involved in maturity, reproduction and survival correlate along a fast–slow continuum of life histories. Evolutionary theories and empirical results...Full Text Available

2010-09-22

490

Activation of the subventricular zone in multiple sclerosis: Evidence for early glial progenitors  

UK PubMed Central (United Kingdom)

In multiple sclerosis (MS), oligodendrocyte and myelin destruction lead to demyelination with subsequent axonal loss. Experimental demyelination in rodents has highlighted the activation of the subventricular...Full Text Available

2007-03-13

491

Absolute dimensions of unevolved O type close binaries  

Energy Technology Data Exchange (ETDEWEB)

A method is presented to derive the absolute dimensions of early-type detached binaries by combining the observed parameters with results of evolutionary computations. The method is used to obtain the absolute dimensions of nine close binaries. We find that most systems have an initial masss ratio near 1.

1984-03-15

492

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells  

UK PubMed Central (United Kingdom)

Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the second most common cause of early-onset dementia. Mutations in the progranulin gene are a major cause of familial...Full Text Available

2011-03-15

493

A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer  

UK PubMed Central (United Kingdom)

IntroductionVarious multigene predictors of breast cancer clinical outcome have been commercialized, but proved to be prognostic only for hormone receptor (HR) subsets overexpressing...Full Text Available

2010-01-01

494

A decrease in retinal progenitor cells is associated with early features of diabetic retinopathy in a model that combines diabetes and hypertension  

UK PubMed Central (United Kingdom)

PurposeHyperglycemia and hypertension contribute to the development of diabetic retinopathy, and this may involve alterations in the normal retinal cell cycle. In this work, we examined...Full Text Available

495

A Review of the Biochemistry, Metabolism and Clinical Benefits of Thiamin(e) and Its Derivatives  

UK PubMed Central (United Kingdom)

Thiamin(e), also known as vitamin B1, is now known to play a fundamental role in energy metabolism. Its discovery followed from the original early research on the ‘anti-beriberi factor’...Full Text Available

2006-03-01

496

A Research Agenda for Malaria Eradication: Drugs  

UK PubMed Central (United Kingdom)

Antimalarial drugs will be essential tools at all stages of malaria elimination along the path towards eradication, including the early control or “attack” phase to drive down transmission...Full Text Available

2011-01-01

497

?-Opioid System Regulates the Long-Lasting Behavioral Adaptations Induced by Early-Life Exposure to Methylphenidate  

UK PubMed Central (United Kingdom)

Methylphenidate (MPH) is commonly prescribed in childhood and adolescence for the treatment of attention–deficit/hyperactivity disorders. In rodents, MPH exposure during preadolescence...Full Text Available

2009-04-01

498

1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis  

UK PubMed Central (United Kingdom)

BackgroundPathophysiological mechanisms involved in amyotrophic lateral sclerosis (ALS) are complex and none has identified reliable markers useful in routine patient evaluation....Full Text Available