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Antiquitin (ATQ) deficiency is the main cause of pyridoxine dependent epilepsy characterized by early onset epileptic encephalopathy responsive to large dosages of pyridoxine. Despite seizure control most patients have intellectual disability. Folinic acid responsive seizures (FARS) are genetically identical to ATQ deficiency. ATQ functions as an aldehyde dehydrogenase (ALDH7A1) in the lysine degradation pathway. Its deficiency results in accumulation of ?-aminoadipic semialdehyde (AASA), piperideine-6-carboxylate (P6C) and pipecolic acid, which serve as diagnostic markers in urine, plasma, and CSF. To interrupt seizures a dose of 100mg of pyridoxine-HCl is given intravenously, or orally/enterally with 30mg/kg/day. First administration may result in respiratory arrest in responders, and thus treatment should be performed with support of respiratory management. To make sure that late and masked response is not missed, ...

UK PubMed Central (United Kingdom)

SynopsisEarly detection of late onset neonatal sepsis, prior to obvious and potentially catastrophic clinical signs, is an important goal in neonatal medicine. Sepsis causes a...Full Text Available

UK PubMed Central (United Kingdom)

Sunbed use is associated with increased risk of melanoma. Younger people might be more susceptible to the carcinogenic effects of ultraviolet radiation. We investigated the association between...Full Text Available

UK PubMed Central (United Kingdom)

IntroductionSeizures with or without trauma may cause fractures that occur commonly in epileptic seizures. Fracture risk is less reported in non-epileptic seizures. Some metabolic...Full Text Available

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BackgroundMitochondrial dysfunction, oxidative damage and the accumulation of somatic mutations in mitochondrial DNA (mtDNA) have been associated with certain neurodegenerative disorders....Full Text Available

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BackgroundRecessive mutations in guanylate cyclase-1 (Gucy2d) are associated with severe, early onset Leber congenital amaurosis-1(LCA1). Gucy2d...Full Text Available

UK PubMed Central (United Kingdom)

A paradoxical metabolic imbalance in inorganic phosphate occurs from the early onset of diabetes and may lead to a reduction of high energy phosphates and tissue hypoxia. These changes take place in...Full Text Available

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Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the second most common cause of early-onset dementia. Mutations in the progranulin gene are a major cause of familial...Full Text Available

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HCV infection continues to spread at an alarming rate among IDU populations. The available evidence suggests that HCV is acquired relatively quickly following onset of injection. However, there are few prospective studies of HCV acquisition, particularly among IDU populations in resource-poor settings. A sample of young male heroin injectors with recent onset of injection (<4?years) was recruited in Hanoi, Vietnam for a prospective assessment of the early course of injection (n?=?179). Both behavioral and biological assessments (including detailed retrospective assessment of injection initiation) were conducted at baseline and repeated at 6-month intervals for a period of 16?months. Variables associated with HCV infection (p value?p value?=?0.0005). In multivariate logistic regression anal...

International Nuclear Information System (INIS)

Six patients with diskitis following lumbar disk surgery were investigated by Computed Tomography (CT). Four patients underwent CT in a rather early phase of the disease (5-37 days after the onset of the symptoms): a posterior paravertebral fluid collection was always recognized, while the plain film was normal. Later on (2-4 months), the classical signs of diskitis were evident, with both CT and the plain film. The collection was always present at CT. A reintervention, performed on 3 patients, revealed the purulent content of the collections. It seems reasonable to suggest a relationship between the collection and the subsequent diskitis; the collection is probably an early sign of the disease. Its detection is of grat value, because it could allow an immediate and adequate therapy. The authors stress the usefulness of performing CT in an early phase on this kind of symptomatic patients.

UK PubMed Central (United Kingdom)

In this study, we aimed to demonstrate whether spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal derived from resting state functional magnetic resonance imaging (fMRI) reflect...Full Text Available

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Stargardt`s disease (MIM 248200), originally described in 1909, is an autosomal recessive condition of childhood, characterized by a sudden and bilateral loss of central vision. Typically, it has an early onset (7 to 12 years), a rapidly progressive course and a poor final outcome. The central area of the retina (macula) displays pigmentary changes in a ring form with depigmentation and atrophy of the retinal pigmentary epithelium (RPE). Perimacular yellowish spots, termed fundus flavimaculatus, are observed in a high percentage of patients. We have recently reported the genetic mapping of Stargardt`s disease to chromosome 1p13. On the other hand, considering that fundus flavimaculatus (MIM 230100) is another form of fleck fundus disease, with a Stargardt-like retinal aspect but with a late-onset and a more progressive course, we decided to test the hypothesis of allelism between typical Stargardt`s disease and ...

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Abstract Human mesenchymal stem cells (hMSCs) may be used for therapeutic applications. Culture conditions such as the serum source may impact on cell quality and the onset of replicative senescence. We have examined the effect of culturing hMSCs in autologous serum (AS) versus fetal bovine serum (FBS) on factors involved in in vitro replicative senescence. hMSCs from four donors were cultured in 10% FBS or 10% AS until they reached senescence. Cells were harvested at early passage and near senescence to study factors known to be involved in cellular senescence. The number of population doublings till senescence was similar for cells cultured in FBS, but varied greatly for hMSCs cultured in AS. FBS cells accumulated in S phase of cell cycle. This could not be explained by increased express...

International Nuclear Information System (INIS)

Acute vertebrobasilar occlusion (VBO) is associated with a high risk of stroke and death. Although local thrombolysis may achieve recanalization and improve outcome, mortality is still between 35% and 75%. However, without recanalization the chance of a good outcome is extremely poor, with mortality rates of 80-90%. Early treatment is a fundamental factor, but detailed studies of the exact time management of the diagnostic and interventional workflow are still lacking. Data on 18 patients were retrospectively evaluated. Time periods between symptom onset, admission to hospital, time of diagnosis, and beginning of intervention were correlated with postinterventional neurological status. The Glasgow Coma Scale and National Institute of Health Stroke Scale (NIHSS) were used to examine patients before and after local thrombolysis. Additionally, multivariate statistics were applied to reveal similarities between patients with neurological ...

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A cohort of singleton black human females exposed to diagnostic x-ray in utero and controls matched by parity, hospital of birth and birthdate have been followed to ages 25 to 30 years in Baltimore, Maryland. The search for possible effects of prenatal irradiation has focused on health, growth, development, and reproductive experience of exposed and control women. This paper reports findings related to reproductive experience. From an original data set of 1458 matched exposed-control pairs of women, questionnaire responses were received from 1109 exposed and 1124 control women including 852 each from pairs in which both the exposed and control woman responded. After careful search for alternative explanations of the findings, the authors concluded that females exposed in utero to low doses of x-ray (probably 1 to 5 rads) had significant increases in their rates of early onset of menses, births at age 15 years or less, numbers of living ...

International Nuclear Information System (INIS)

Leukodystrophies are inherited white matter diseases due to abnormalities occurring in myelin synthesis and/or maintenance. The most common types of these rare childhood conditions are represented by adrenoleukodystrophy, metachromatic leukodystrophy, Canavan's, Alexander's, Krabbe's, and Pelizaeus-Merzbacher's diseases. Most of them are lethal during childhood, with the exception of the adrenoleukodystrophy-adrenomyeloneuropathy complex, which sometimes, during its early phases, may be cured with a dietary therapy. The aims of this paper are: 1) the description of inheritance factors, pathogenesis, pathological and clinical findings of each of the most frequent childhood leukodystrophies; 2) the description of the most common patterns of these conditions on CT and MR imaging; 3) the evaluation of the diagnostic capabilities of these two imaging techniques and the comparison of their results. Finally, some of the therapies suggested for the mild forms of these ...

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The accurate measurement of a stress level is one of the most important issues in a stress diagnosis and its measurement could be of great value in clinical medicine. Stress has a potent effect on the spirit and physical condition of an individual. There are various methods available for its measurement. Some of the commonly used techniques for the diagnosis of a stress level include analysis of the body fluids, questionnaire assessments, psychophysiological evaluations and by determining heart rate variability (HRV) of subjects. However, the existing diagnostic methods have several defects like, a low sensitivity, inaccuracy and long of operation time. In this report, we present a diagnostic technology to detect a stress level which is the origin of various diseases. This method can be of great help in providing an early diagnosis through a biosensor and might play a vital role in preventing diseases like hypochondria and hypertension. Majority of the human ...

UK PubMed Central (United Kingdom)

Background:We analyzed the effects of a docosahexaenoic acid (DHA) supplementation in patients affected with late onset Stargardt disease (STGD).Methods:DHA...Full Text Available

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A gene designated BRCA1, implicated in the susceptibility to early-onset familial breast cancer, has recently been localized to chromosome 17q12-q21. To date, the order of DNA markers mapped within this region has been based on genetic linkage analysis. The authors report the use of multicolor fluorescence in situ hybridization to establish a physically based map of five polymorphic DNA markers and 10 cloned genes spanning this region. Three cosmid clones and Alu-PCR-Generated products derived from 12 yeast artificial chromosome clones representing each of these markers were used in two-color mapping experiments to determine an initial proximity of markers relative to each other on metaphase chromosomes. Interphase mapping was then employed to determine the order and orientation of closely spaced loci by direct visualization of fluorescent signals following hybridization of three probes, each detected in a different color. Statistical analysis of the combined data ...

International Nuclear Information System (INIS)

The extracellular matrix (ECM) of the distal tissues in a newt limb stump is completely reorganized in the 2-3-week period following amputation. In view of numerous in vitro studies showing that extracellular material influences cellular migration and proliferation, it is likely that the changes in the limb's ECM are important activities in the process leading to regeneration of such limbs. Using biochemical, autoradiographic, and histochemical techniques we studied temporal and spatial differences in the synthesis of glycosaminoglycans (GAGs) during the early, nerve-dependent phase of limb regeneration. Hyaluronic acid synthesis began with the onset of tissue dedifferentiation, became maximal within 1 weeks, and continued throughout the period of active cell proliferation. Chondroitin sulfate synthesis began somewhat later, increased steadily, and reached very high levels during chondrogenesis. During the first 10 days after amputation, ...

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An analytical study of the ice-formation process associated with heat-conducting plates located perpendicularly to isothermally heated and cooled surfaces with some clearance is presented. It is proposed that the onset conditions, which describe whether the ice-volume fraction in a steady state is greater than or less than that without heat-conducting plates, are defined by the dimensionless distances between the heated/cooled walls and the heat-conducting plates. It is shown that the onset conditions are dependent on the pitch and the thickness of the heat-conducting plates and are less dependent on the thermal conductivity of the plates.

UK PubMed Central (United Kingdom)

BackgroundLate-onset sepsis in the premature infant is frequently revealed by severe, unusual and recurrent bradycardias. In view of the high morbidity and mortality...Full Text Available

UK PubMed Central (United Kingdom)

A diagnosis of dementia is devastating at any age but diagnosis in younger patients presents a particular challenge. The differential diagnosis is broad as late presentation of metabolic disease...Full Text Available

International Nuclear Information System (INIS)

The experimental technique used for detection of subcooled boiling through analysis of the fluctuation contained in pressure transducer signals is presented. This work was partly conducted at the Institut fuer Kerntechnik und zertoerungsfreie Pruefverfahren von Hannover (IKPH, Germany) in a thermal-hydraulic circuit with one electrically heated rod with annular geometry test section. Piezo resistive pressure sensors are used for onset of nucleate boiling (ONB) and onset of fully developed boiling (OFDB) detection using spectral analysis/ signal correlation techniques. Experimental results are interpreted by phenomenological analysis of these two points and compared with existing correlation. The results allow to conclude that this technique is adequate for the detection and monitoring of the ONB and OFDB. (author)

UK PubMed Central (United Kingdom)

ObjectiveNeuralgic amyotrophy (NA) is a distinct clinical syndrome that is characterized by the acute onset of shoulder and arm pain, weakness, and sensory loss. The purpose of this...Full Text Available

UK PubMed Central (United Kingdom)

An elderly man receiving chlorambucil for chronic lymphatic leukaemia developed focal fits. The onset and frequency were dose related. There was no evidence of metabolic disturbance or of meningeal...Full Text Available

Science.gov (United States)

PMID:1799068

UK PubMed Central (United Kingdom)

A retrospective epidemiological study (n = 7,875) of neurologically expressed disorders (NED) in ruminants before the onset of the bovine spongiform encephalopathy epidemic...Full Text Available

International Nuclear Information System (INIS)

The evaluate the signs of aortic intramural hematoma with helical CT and the diagnostic role of this technique in patients with this condition. It was reviewed the CT findings of 396 patients submitted to emergency examinations for suspected aortic dissection from 1995 to 1999. Only 18 patients (6 women and 12 men) had CT signs of aortic intramural hematoma. Helical CT studies were carried out with the following parameters: slice thickness 10 mm, reconstruction index 10, feed 1.5 mm, conventional algorithm with minimum values of 130 kV and 125mA. All patients were examined with dynamic contrast-enhanced CT, before and after a power injection of 130 mL ionic contrast material. It was studied: hematoma localization and longitudinal extension; thickness and density of aortic wall; presence and location of intimal calcifications; integrity of intimal wall; hemo mediastinum and/or hemo thorax. Aortic wall thickening appeared as a high density crescent-shaped area at baseline CT and had low ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Aim- According to the revised Bethesda Guidelines, colorectal cancer (CRC) occurring under age 50-years should be screened to exclude Lynch syndrome. However, in current practice in East Anglia, tumour screening is initiated only after genetics referral, reserved for those with a strong pedigree. This study aimed to determine how many patients with young-onset CRC undergo tumour screening in hospitals in East Anglia. Method- A retrospective case notes review over 5-years in four hospitals was undertaken to determine what proportion of those with young-onset CRC underwent referral for tumour screening and to assess local practices in terms of patient counselling and management. Results- One hundred and twenty-two patients were included. There was an average yearly caseload of 6-9 p...

UK PubMed Central (United Kingdom)

Werner syndrome (WS) is characterized by premature onset of age-associated disorders and predisposition to cancer. The WS protein, WRN, encodes 3′ → 5′ DNA helicase and 3′...Full Text Available

UK PubMed Central (United Kingdom)

Spontaneous spinal epidural hematoma is a rare cause of acute spinal cord compression. A 25-year-old male presented with a history of sudden onset of complete quadriplegia with sensory loss below the...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundIn many gregarious mammals, mothers and offspring have developed the abilities to recognise each other using acoustic signals. Such capacity may develop at different rates...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Onset of convection in a layer of couple-stress fluid-saturated porous medium is investigated for different types of basic temperature gradients. The boundaries are considered to be adiabatically insulated to temperature perturbations. The eigenvalue equations of the perturbed state obtained from the normal mode analysis are solved analytically using a regular perturbation technique with wave number as a perturbation parameter and also numerically using the Galerkin technique. The critical stability parameters obtained from these two techniques are in excellent agreement and an increase in the value of couple-stress parameter is found to delay the onset of convection. The results also indicate that the piecewise linear temperature profile hastens the onset of convection when compared to linear, parabolic, and inverted parabolic temperature profiles. In addition, the influence of thermal depth on the critical conditions is ...

UK PubMed Central (United Kingdom)

Objectives:Copy number variants (CNVs) have been recognized as a source of genetic variation that contributes to disease phenotypes. Alzheimer disease (AD) has high heritability...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVEThis randomized, four-arm, placebo-controlled, dose-ranging phase 2 trial was conducted to determine whether repeated subcutaneous injections of the altered peptide ligand,...Full Text Available

UK PubMed Central (United Kingdom)

Objective:Parkinson disease (PD) may affect the autonomic nervous system and may cause constipation; however, few studies have explored constipation preceding the motor onset of...Full Text Available

UK PubMed Central (United Kingdom)

Werner Syndrome (WS) is an inherited disease characterized by premature onset of aging, increased cancer incidence, and genomic instability. The WS gene encodes a 1,432-amino acid polypeptide (WRN)...Full Text Available

UK PubMed Central (United Kingdom)

A number of aberrant morphological phenotypes were noted during propagation of the Arabidopsis thaliana DNA hypomethylation mutant, ddm1, by repeated self-pollination. Onset of a spectrum of morphological...Full Text Available

UK PubMed Central (United Kingdom)

Aims:To investigate the relationship between the duration of comatose state, severity of rhabdomyolysis and frequency of peripheral nerve injury (PNI) in patients following...Full Text Available

UK PubMed Central (United Kingdom)

Growing evidences indicate that proteases are implicated in adipogenesis and in the onset of obesity. We previously reported that the cysteine protease cathepsin K (ctsk) is overexpressed in the white...Full Text Available

UK PubMed Central (United Kingdom)

Objective: Determine and compare the prevalence of known risk factors for cardiovascular disease among unselected individuals presenting with their first ever episode of...Full Text Available

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Knock limitations are investigated using natural gas, with diesel pilot ignition, as a fuel for the 3406 DI-TA Caterpillar diesel engine. Thermodynamic properties at TDC are generated by computer and compared with experimental results. Exhaust emissions are analyzed. A comparison is made of dual-fuel operation relative to diesel. Observations are made to determine the onset of knock. The onset of knock is characterized as a function of engine speed, load, inlet manifold temperature, and air-fuel ratio (A/F). The conditions at the inset of knock are determined using cylinder pressure data. The most efficient operating range is determined with knock avoidance as a prime parameter.

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Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiological disorder of early childhood onset. Defining symptoms are chronic impairments of attention, impulse control and motor hyperactivity that frequently persist until adulthood. Miscellaneous causes of the disorder have been discussed. Accumulating evidence from imaging- and molecular genetic studies strengthened the theory of ADHS being a predominantly inherited disorder of neurobiological origin. In the last 15 years, non-invasive brain imaging methods were successfully implemented in pediatric research. Functional magnetic resonance imaging studies gave major insight into the neurobiological correlates of executive malfunction, inhibitory deficits and psychomotoric soft signs. These findings are in good accordance with brain morphometric data indicating a significant volumetric decrease of major components of striato-thalamo-cortical feedback loops, primarily influencing ...

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Science.gov (United States)

Pancreatic Cancer; Head and Neck Cancer; Breast Cancer

UK PubMed Central (United Kingdom)

A series of deletion mutants extending from -250 toward the capsite has been constructed in the early promoter region of the adenovirus 2 EIIa gene and tested both in vitro, and in vivo after transfection...Full Text Available

UK PubMed Central (United Kingdom)

AbstractStudies performed to identify early events of ovarian cancer and to establish molecular markers to support early detection and development of chemopreventive regimens have been...Full Text Available

UK PubMed Central (United Kingdom)

Cognitive rehabilitation is an effective intervention for addressing cognitive impairments in patients with schizophrenia. Previous research has shown that the early application of Cognitive...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe precise mechanisms involved in the initiation and progression of rheumatoid arthritis (RA) are not known. Early stages of RA often have non-specific symptoms, delaying...Full Text Available

UK PubMed Central (United Kingdom)

Photodynamic therapy (PDT) is an established endoscopic technique for ablating Barrett’s esophagus with high-grade dysplasia or early-stage intraepithelial neoplasia. The most common clinically...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundPeak bone mass, attained by early adulthood, is influenced by genetic and life-style factors. Early infant feeding and duration of breastfeeding in particular, associate...Full Text Available

UK PubMed Central (United Kingdom)

In both humans and songbirds, infants learn vocalizations by imitating the sounds of adult tutors with whom they interact during an early sensitive period. Vocal learning occurs in few animal taxa;...Full Text Available

UK PubMed Central (United Kingdom)

Higher plants use photoperiodic cues to regulate many aspects of development, including the transition from vegetative to floral development. The EARLY FLOWERING3 (ELF3)...Full Text Available

UK PubMed Central (United Kingdom)

Early simian virus 40-specific mRNA was isolated from lytically infected and stably transformed cells and analyzed with respect to the 5'-terminal cap content. An analogous diversity of capped structures...Full Text Available

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Purpose of reviewTo summarize recent advances in the classification of preradiographic axial spondyloarthritis (SpA).Recent findingsFull Text Available

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...global warming such such a pressing ...global warming and actually for all climate change problems that ...for the global warming problem ...

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Methods: A total of 253 locomotive engineers (249 male, 4 female, mean age 39.7 years) participated. Data were collected at 14 rail depots, where participants drove electric or diesel locomotives;...Full Text Available

International Nuclear Information System (INIS)

Carbon fibre composite (CFC) was irradiated by hot plasma streams at plasma gun facility MK-200UG. The CFC targets were tested by plasma loads relevant to Edge Localized Modes (ELM) and mitigated disruptions in ITER. Onset condition of CFC evaporation and properties of evaporated carbon were studied by use of infrared pyrometry and visible spectroscopy.

UK PubMed Central (United Kingdom)

Recent GWAS studies focused on uncovering novel genetic loci related to AD have revealed associations with variants near CLU, CR1, PICALM and BIN1....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

According to the invention, a zinc foil is arranged between the negative electrode of a zinc/air battery (round cell) and the expansion space compensating for the reactive increase in volume of the zinc powder. This zinc foil functioning as a stop diaphragm particularly ensures, from the very onset, that the zinc filling has a density and compactness necessary for good electronic conductance.

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High-spatial-resolution microfocus-based X-ray imaging technology, both real-time and film, has been used to study the thickness variation that occurs in the oxide core of silver-sheathed BSCCO ribbons produced by the powder-in-tube method. This thickness variation (also called ``sausaging``) occurs during incremental rolling and degrades the critical current densities of the ribbons. Using X-ray image data the authors determined the onset and severity of sausaging. Onset occurred at a ribbon thickness of 203 {micro}m, and the severity increased with subsequent rolling reductions. Scanning electron microscopy was used to confirm the X-ray image data. X-ray imaging provides several advantages over more traditional methods for characterizing the superconductors such as optical or scanning electron microscopy. The X-ray imaging provides nondestructive information about the entire width of the ribbon, with far greater speed, lower cost, and more ...

International Nuclear Information System (INIS)

The onset of double-diffusive convection in a couple-stress fluid-saturated horizontal porous layer is studied using linear and weak nonlinear stability analyses. The modified Darcy equation that includes the time derivative term and the inertia term is used to model the momentum equation. The expressions for stationary, oscillatory and finite-amplitude Rayleigh number are obtained as a function of the governing parameters. The effect of couple-stress parameter, solute Rayleigh number, Vadasz number and diffusivity ratio on stationary, oscillatory and finite-amplitude convection is shown graphically. It is found that the couple-stress parameter and the solute Rayleigh number have a stabilizing effect on stationary, oscillatory and finite-amplitude convection. The diffusivity ratio has a destabilizing effect in the case of stationary and finite-amplitude modes, with a dual effect in the case of oscillatory convection. The Vadasz number advances the ...

British Library Electronic Table of Contents (United Kingdom)

Huntington?s disease (HD) is caused by an expansion of a polyglutamine repeat of more than 35?units in the huntingtin protein. The expanded repeat length is inversely correlated with the age at onset (AAO); however, additional genetic factors apart from the expanded CAG repeat length can modify the course and the AAO in HD. Aberrations in macroautophagy have been observed in Huntington, Alzheimer, Parkinson, motor neuron and prion diseases. Therefore, we hypothesized that polymorphisms in autophagy-related (Atg) genes might contribute to the variation in the AAO. We initially tested eight single nucleotide polymorphisms in five Atg genes (Atg3, Atg5, Atg7, Atg16L1 and Beclin-1) for their frequency of ?1%. Subsequently, we investigated the polymorphisms Atg7 V471A and Atg16L1 T281A for a di...

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The bibliography contains citations concerning the pitting corrosion of copper and copper alloys, in different media, with some references to methods for protecting against such corrosion. Included are factors contributing to the onset of pitting corrosion. Emphasis is placed on exposure to water, especially in tubing for heat exchangers and water conduits. Many of the citations present studies on exposure to sea water. Some references pertain to the detection of pitting corrosion in installations and the evaluation of the degree of pitting present. (Contains 250 citations and includes a subject term index and title list.)

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The problem of thermal instability of compressible, electrically conducting couple-stress fluids in the presence of a uniform magnetic field is considered. Following the linearized stability theory and normal mode analysis, the dispersion relation is obtained. For stationary convection, the compressibility, couple-stress, and magnetic field postpone the onset of convection. Graphs have been plotted by giving numerical values of the parameters to depict the stability characteristics. The principle of exchange of stabilities is found to be satisfied. The magnetic field introduces oscillatory modes in the system that were non-existent in its absence. The case of overstability is also studied wherein a sufficient condition for the non-existence of overstability is obtained. (orig.)

International Nuclear Information System (INIS)

Multi-machine experimental observations indicate resilience in the temperature profiles at low pedestal temperatures,whereas at high pedestal temperatures the profile stiffness seems to disappear.The change of the profile behavior impacts the energy confinement,basically due to a strong non-linear dependence of the energy transport on the pedestal temperature together with different critical conditions for the onset of turbulence in the ions and electrons.This possible explanation for the different observations is based on the assumption that both ion and electron energy transport is governed by turbulence which sets in at a critical temperature gradient as well as on a significant energy equipartition between electrons and ions.

Science.gov (United States)

integrates multiple fisheries information systems to obtain a view of U.S. freshwater fish distribution. Information about NFDI National Framework for Early Detection, Rapid...

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... Army 2nd Brigade, 82nd Airborne Division Fort Bragg, NC January, 2007 ... 1st Brigade, 82nd Airborne Division Fort Bragg, NC early-2007 ...

UK PubMed Central (United Kingdom)

The immediate early gene Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information...Full Text Available

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... mast cell staining; ref. 16). The severity of structural radiation injury was assessed using a histopathological radiation injury score ... ...

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Four low activation alloy classes, two austenitic and two ferritic, have been incorporated into the MOTA-1B experiment in the FFTF reactor to provide an early assessment of the suitability of such alloys for reactor service.

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This paper reviews the historical aspects of nuclear physics. The scientific aspects of the early transuranium elements are discussed and arms control measures are reviewed. 11 refs., 14 figs. (LSP)

UK PubMed Central (United Kingdom)

Weaning of beef calves is usually done abruptly and early compared to the natural weaning of the species, and is associated with simultaneous exposure of calves to a range of social and environmental...Full Text Available

UK PubMed Central (United Kingdom)

Models can be useful at many different levels when considering complex issues such as biological control of mosquitoes. At an early stage, exploratory models are valuable in exploring the characteristics...Full Text Available

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Two-way communication between the conceptus and the mother during early pregnancy is essential if the pregnancy is to survive. In this review, our primary focus is on biochemical communication...Full Text Available

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goals for multisensor co-registration and fusion. 6 - 12.5 Km ..... Beta-Test toolkit for cyclogenesis and early evolution of cyclones ...

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rotor flow field in which the main rotor operates. The majority of ..... early separation predicted by their CFD code was ...... Airfoil, AGARD Fluid Dynamics Panel ...

International Nuclear Information System (INIS)

... brain take place. This highly plastic period offers the possibility for

UK PubMed Central (United Kingdom)

Specialized olfactory lobe glomeruli relating to sexual or caste differences have been observed in at least five orders of insects, suggesting an early appearance of this trait in insect evolution....Full Text Available

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BackgroundAutofluorescence bronchoscopy is more sensitive than conventional bronchoscopy for detecting early airway mucosal lesions. Decreased specificity can lead...Full Text Available

UK PubMed Central (United Kingdom)

Mutations in the Drosophila gene drop-dead (drd) result in early adult lethality and neurodegeneration, but the molecular identity of the drd...Full Text Available

UK PubMed Central (United Kingdom)

Following a brief overview of the terrestrial distribution of boron in rocks, soil, and water, the history of the discovery, early utilization, and geologic origin of borate minerals is summarized....Full Text Available

International Nuclear Information System (INIS)

The thermal behaviour of 21 proteinaceous l-amino acids either as pristine samples and also as radiolyzed (3.2 MGy) samples was studied with the differential scanning calorimeter. The onset and peak melting point as well as the melting enthalpy of all samples before and after the radiation treatment was measured and reported. The residual amount of each amino acid survived to the radiation dose of 3.2 MGy (N_#gamma#) was measured from the melting enthalpies before and after radiolysis and hence the radiation resistance of each amino acid has been determined. The radiolysis causes a systematic reduction of the melting enthalpy and a shift of the onset and peak melting point to lower values. It is shown that N_#gamma# does not correlate with the melting points of the amino acids but shows a correlation with the entity of the shift of the melting point peaks occurred after radiolysis. Such correlation instead does not exist between the N_#gamma# ...

Science.gov (United States)

Epulopiscium sp. type B is an enormous intestinal symbiont of the surgeonfish Naso tonganus. Intracellular offspring production in Epulopiscium shares features with endospore formation. Here, we characterize the spoIIE homolog in Epulopiscium. The timing of spoIIE gene expression and presence of interacting partners suggest that the activation of ?(F) occurs early in Epulopiscium offspring development. PMID:21398534

UK PubMed Central (United Kingdom)

Three transcription units are present in the adenovirus type 2 region EII. Transcription units EIIaE and EIIaL encode the mRNA for the 72,000-dalton DNA binding protein, early and late in the lytic...Full Text Available

CERN Document Server

Recent nucleosynthesis calculations of Type II supernovae using advanced neutrino transport determine that the early neutrino winds are proton-rich. However, a fraction of the ejecta emitted at the same time is composed of neutron-rich pockets. In this paper we calculate the nucleosynthesis contribution from the neutron-rich pockets in the hot convective bubbles of a core-collapse supernova and show that they do not contribute significantly to the total nucleosynthesis.

UK PubMed Central (United Kingdom)

BackgroundApoptosis is a major mode of hematological tumor death after radiation. Early detection of apoptosis may be beneficial for cancer adaptive treatment. ^99mTc-HYNIC-annexinV...Full Text Available

Environmental Research Database

DescriptionThe overall aim of this application is to examine experimentally environmental influences on the pattern of senescence in birds. We plan to experimentally uncouple chronological age and reproductive effort and examine their effects on reproductive performance and lifespan. We also plan to examine experimentally how these relationships are influenced by nutritional conditions during early development. We will combine the organismal fitness measures of lifespan and reproductive performance with me [continued...

Science.gov (United States)

Elution profiles of total lipoproteins, apolipoprotein B (apoB) concentrations in lipoproteins, and plasma triglyceride (TG) levels were examined in early-, late-, and non-lactating cows. Additionally, arteriovenous (A-V) differences were also measured to elucidate the uptake of TG and apoB-containing lipoproteins in mammary gland. Non-lactating cows showed three major peaks corresponding to triglyceride-rich lipoprotein (TRL), low density lipoprotein (LDL), and high density lipoprotein (HDL) fraction, whereas both early- and late-lactating cows revealed two peaks corresponding to TRL and HDL. The peak area of TRL in early- and late-lactating cows were significantly (p < 0.05) smaller than that in non-lactating cows. The plasma TG levels and apoB-48 concentrations of TRL in early- and late-lactating cows were also significantly (p < 0.01) lower. Furthermore, early lactating ...

British Library Electronic Table of Contents (United Kingdom)

The paper investigates early Soviet policies regarding the institution of waqf (charitable endowment) in Turkestan, questioning the issue of the post-colonial character of the early Soviet administration. After taking into consideration practices related to waqf management in modern Muslim states and European colonial empires, the paper briefly describes the tsarist administrative approach to the issue. We then address the ambiguity inherent in Soviet policies on waqf requisition and restitution during Civil War years. In the section that follows we deal with different groups of Muslim intellectuals that attempted to use the Soviet state in their mutual struggle over authority in Central Asian society and describe the creation and functioning of the bureaucracies responsible for managing w...

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There are no specific diagnostic tests or a gold standard method for measuring disease activity and outcome in spondyloarthropathies (SpA). Many different methods have been developed to assess the signs and symptoms in SpA. The aim of this study was to evaluate the value of scintigraphy, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and Bath Ankilosing Spondylitis Disease Activity Index (BASDAI) in the evaluation of disease activity in early axial SpA diagnosed with magnetic resonance imaging (MRI). Thirty early MRI-positive axial SpA patients (23 males, 7 females) with a median age of 35 (18?55) years and a median duration of inflammatory low back pain of 24 (8?60) months were included in the study. In the patients with sacroiliitis, the sensitivity, specificity, and pos...

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Climate variability greatly affects animals through direct and indirect effects. Animals with slow reproductive adaptation to ecological changes such as large mammals are likely to have evolved mechanisms to anticipate early such impacts of climate variability on the environment. One of the adaptive mechanisms between reproductive costs and benefits in mammals affects parental investment through biases in sex ratio. Deer might be likely to show an early detection of climate variability because conception takes place in early autumn, but the main raising cost in deer concerns lactation, which takes place at the end of the following spring. The aim of this paper is to assess whether there is a relationship between global indices of climate variability such as El Ni?o-Southern Oscillation (EN...

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Background.There are no suitably powered epidemiological studies of `transient azotaemia' (TA). The objective of this study was to describe the epidemiology of TA and its independent association with hospital mortality. We hypothesized that TA would be associated with an independent increase in the risk of death. Methods.We retrospectively studied all patients admitted to a university-affiliated hospital in Australia between January 2000 and December 2002. Patients were excluded if they were <15 years old, were on chronic dialysis, had kidney transplant or if their length of hospital stay was <24 hours. We defined TA as rapidly recovering acute kidney injury (AKI) (return to no-AKI risk, injury, failure, loss, end stage (RIFLE) class within 72 hours of onset). We performed descriptive and ...

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Previous family and twin studies have indicated that Graves' disease has a heritable component. Family studies have also shown that some autoimmune disease cluster in families and genetic studies have been able to show shared susceptibility genes. In the present nation-wide study we describe familial risk for Graves' disease among parents and offspring, singleton siblings, twins and spouses with regard to age of onset, gender and number and type of affected family members. Additionally familial association of Graves' disease with any of 33 other autoimmune and related conditions was analyzed. The Swedish Multigeneration Register on 0-75-year-old subjects was linked to the Hospital Discharge Register from years 1987-2007. Standardized incidence ratios (SIRs) were calculated for individuals ...

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The double diffusive convection in a horizontal couple stress fluid saturated anisotropic porous layer, which is heated and salted from below, is studied analytically. The modified Darcy equation that includes the time derivative term is used to model the momentum equation. The critical Rayleigh number, wavenumber for stationary and oscillatory modes, and frequency of oscillations are obtained analytically using linear theory. The effect of anisotropy parameter, solute Rayleigh number, Lewis number, couple stress parameter, and Vadasz number on the stationary, oscillatory, and finite amplitude convection is shown graphically. It is found that the thermal anisotropy parameter, couple stress parameter, and solute Rayleigh number have stabilizing effect on the stationary, oscillatory, and fin...

International Nuclear Information System (INIS)

It is found that below 80 K o-TaS_3 demonstrates spontaneous resistance fluctuations growing when the temperature is decreasing. The average relaxation time, #tau#_0, obtained from the noise spectra demonstrates activated behavior, #tau#_0 #propor to# exp(W/T), W #approx# 1300 K for 50 < or #approx# T < or #approx# 70 K. In the vicinity of the threshold the average frequency of the fluctuations, f_0, grows with increasing the voltage, revealing onset of the Froehlich current. log(f_0) is found to be proportional to the increase of conductivity. We conclude that the main source of the resistance fluctuations are thermally-assisted jumps of dislocations of the charge-density waves. (orig.).

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Reactions of reducing species from acetonitrile media with silver iodide particles (#approx#25-angstrom diameter) have been investigated by pulse radiolysis techniques. Injection of electrons into these ultrasmall particles leads to transient bleaching of the adsorption of AgI at wavelengths close to the onset of absorption (#approx#400 nm) with the concomitant reduction of AgI to metallic silver. The reduction of Ag"+ ions and formation of silver atoms and/or dimeric Ag_2 molecules on three different size AgI particles (#approx#100, 35, and #approx#25 angstrom) have also been examined by picosecond laser spectroscopy.

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Summary The aim of the study was to perform a retrospective review of records to test a possible significant association between sudden, modest weight loss (t-test and Wilcoxon test p values were 0.95 and 0.61, respectively. A Kolmogorov-?Smirnov test p value was 0.2139. A one-half standard deviation difference in time to delivery, approximately 2.5 days, was detectable with 0.95 probability. It was concluded that these data may be the first time this question has been investigated and provide evidence that sudden, modest weight loss at the end of pregnancy is not associated with shorter time to onset of natural labour.

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Summary Objective To find out whether there was over-reporting of SARS patients in mainland China in view of the relatively low case fatality ratio in mainland China, in comparison with other affected countries and areas. Methods We searched PubMed for all SARS antibody detection papers (in English or Chinese language) using the keywords `SARS' and `antibody'. Then the resulting articles were further read through to select the SARS detection results using ELISA methods of serum samples collected at least 1 month after disease onset. A multi-level logistic regression was applied to test for possible differences in the proportions positive between locations of the study. Results A total of 48 studies were identified, including 39 from mainland China and nine from elsewhere (Hong Kong, Taiwan...

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This study provides a comprehensive description of the main morphological and histological events that take place during larval and post-larval development of Senegal sole Solea senegalensis in order to establish a reference for its normal developmental organogenesis. Five stages have been described. Before gill development at the onset of metamorphosis (eye migration process, stage 4c), the skin was the main site of gas and ion exchange, whereas during stages 3 and 4, the skin begins differentiating into the definitive juvenile structure. The timing of development of the endocrine system depends on each organ, the endocrine pancreas and thyroid gland being the first to differentiate (stages 2 and 3, respectively), followed by the interrenal tissue and stannius corpuscles that develop at m...

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Transmission electron microscopy studies on solution-annealed Alloy 800 revealed small (100-200 nm), spherical-shaped titanium carbide (face centered cubic structure) and large (200 nm-5 #mu#m), faceted titanium nitride (hexagonal structure) particles randomly distributed in the austenite matrix. The volume fraction of former particles was found to be greater than that of the latter. Corrosion studies of the alloy in acidic, chlorides and acidic chloride environments at room temperature indicated that the passivity of Alloy 800 was adversely affected by the addition Cl"- ions. X-ray photoelectron spectroscopy revealed that the surface film formed on the alloy at the onset of passivity consisted of Cr"3"+ (as Cr_2O_3), without any Fe"3"+/Fe"2"+ or Ni"2"+. Scanning electron microscopy studies indicated initiation of pitting at large, faceted particles, not at small, spherical-shaped ones.

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The cross-over from a magnetically ordered to a non-magnetic spin liquid state has been investigated in a series of resistance measurements under hydrostatic pressures of up to 30 kbar and at temperatures down to below 200 mK in the heavy fermion antiferromagnet CePd{sub 2}Si{sub 2}. The electrical resistivity changes dramatically with increasing pressure. Near the critical pressure, at which the magnetic ordering temperature is extrapolated to zero, it exhibits a quasi-linear variation over two orders of magnitude in temperature. This non-Fermi liquid form of {rho}(T) extends down to the onset of a new superconducting transition below 430 mK. (orig.).

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To document the range of activity and patterns of normal surface kinesiological electromyography in normal children, 87 children ranging from age 3 to 18 years who were developing normally were evaluated at free walking speed. Analysis was performed on 6307 gait cycles from 11 different muscles with custom software. We devised an algorithm to do a computer-based KEMG curve pattern analysis to sort out curves that did not match the physiologic muscle activity pattern, We also devised a combined preset amplitude and statistics-based criteria to satisfactorily determine the onset/cessation of KEMG activity. The measurements of timing and duration of activity, body height and weight, body mass index, cadence, stride length, and age were obtained for statistical analysis. From the pattern recog...

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Various SST indices in the Indo-Pacific region have been proposed in the literature in light of a long-range seasonal forecasting of the Indian Summer Monsoon (ISM). However, the dynamics associated with these different indices have never been compared in detail. To this end, the present work re-examines the variabilities of ISM rainfall, onset and withdrawal dates at interannual timescales and explores their relationships with El Ni?o-Southern Oscillation (ENSO) and various modes of coupled variability in the Indian Ocean. Based on recent findings in the literature, five SST indices are considered here: Ni?o3.4 SST index in December?January both preceding [Nino(?1)] and following the ISM [Nino(0)], South East Indian Ocean (SEIO) SST in February?March, the Indian Ocean Basin (IOB) mode in ...

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The role of shear in determining the ideal MHD stability properties of tokamaks is discussed. In particular, we assess the effects of low shear within the plasma upon pressure-driven modes. The standard ballooning theory is shown to break down, as the shear is reduced and the growth rate is shown to be an oscillatory function of n, the toroidal mode number, treated as a continuous parameter. The oscillations are shown to depend on both the pressure and safety-factor profiles. When the shear is sufficiently weak, the oscillations can result in bands of unstable n values which are present even when the standard ballooning theory predicts complete stability. These instabilities are named ''infernal modes.'' The occurrence of these instabilities at integer n is shown to be a sensitive function of q-axis, raising the possibility of a sharp onset as plasma parameters evolve. 20 refs., 31 figs.

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Delayed endolymphatic hydrops (DEH) is a unique disorder characterized by fluctuating otologic symptoms in the setting of preexisting unilateral deafness. The symptoms include aural fullness, fluctuating hearing, and/or episodes of vertigo similar to those observed in Meniere disease and may occur ipsilateral or contralateral to the previously deafened ear. In most reported cases, the unilateral deafness has been a profound sensorineural hearing loss with a sudden onset that has been variously attributed to bacterial or viral labyrinthitis, acoustic or cranial trauma, otosclerosis, and congenital CMV infection. Familial occurrence of the syndrome has not previously been reported in the literature. In this report, we describe two possible familial instances of delayed DEH. These patients ra...

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Summary There is a current popular recognition that cigarette smoking is deleterious to health. Although this is very clearly the case for physical health, the situation regarding mental health is, however, rather more complicated. This piece concentrates on the role of smoking in schizophrenia: it is important to consider why schizophrenia, exceptionally amongst the severe and enduring mental illnesses, is associated with increased cigarette consumption. People who suffer from schizophrenia consequently have a greater risk of the complications to physical health caused by this addiction and clearly, it is important to understand why this occurs. Numerous investigators have found that both neuroleptic-naive, first-onset schizophrenics, together with chronic sufferers of the illness, consum...

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The authors obtain the critical load levels corresponding to the onset of spalling microdamage for Armco iron and steels St.3 and 12Kh18N10T in a broad temperature range (-196-800 degrees C. The results of the investigation of the effect of the temperature on spalling fracture are presented. The effect of the loading time on the strength of the investigated materials is also given. The authors assume that at -196 degrees C impact-wave strain-hardening may also be characterized by the value of H obtained for the center of the specimen since measurements on great thicknesses, including those reaching as far as the opposite surface, did not reveal any substantial change of microhardness.

International Nuclear Information System (INIS)

We report on severe accident scenarios consequences evaluation in connection to the applied emergency countermeasures and use of the PC COSYMA code. We present some of the results for the reactor core melt accident assumed to happen at the 632 MWE PWR Krsko Nuclear Power Plant in Slovenia. The efficiency of several potential countermeasures in limiting the late health effects was studied. Regarding the source term, the majority of release parameters are as specified for category 2 in the German Risk Study. Site specific data were used. As the outside (meteorologic) conditions during the potential accident onset can be very different, the study limited to the deterministic runs, assuming the wind direction upstream the Sava river into the WNW direction, wind speed of 5 ms -1 and the C Pasquill stability category. The population distribution file was formed from the NEK-FSAR data for the 1991. (author)

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The activities "1"0"1Mo and "1"0"1Tc produced from neutron capture by natural Mo were chemically separated and studied using Ge(Li) #gamma#-ray detectors. Out of 185 transitions observed in the decay of "1"0"1Mo, 170 were assigned to 44 excited levels in "1"0"1Tc. For the decay of "1"0"1Tc, 26 of 27 transitions were placed among 10 excited levels in "1"0"1Ru. The interpretation of the "1"0"1Tc level scheme using the shell-model approach is not satisfactory even for a five-particle calculation. Systematics of odd-A level structures in the region of A=101 indicate that the level structure of "1"0"1Tc could be due partly to the onset of collective effects.

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Cerium L_3 XANES (x-ray-absorption near-edge-structure) spectra were analyzed to separate Ce moment contributions and mixed valence (MV) in complex magnetic silicides CePd_2_-_xMn_xSi_2 (0#<=#x#<=#2). The Ce valence mixing does not vary linearly with x, but increases rapidly for x#>=#1.5. The associated moment collapse correlates with pronounced deviations of the unit-cell volume from Vegard law and the onset of structural instability. Reorientation of [001] Mn 3d antiferromagnetic order for x<2 appears to rapidly suppress the weak Ce valence mixing coexisting with antiferromagnetic order in CeMn_2Si_2.

Science.gov (United States)

Anaphylaxis is a serious allergic reaction that is rapid in onset and sometimes leads to death. Understanding mechanisms, triggers, and patient-specific risk factors for severe or fatal anaphylaxis is critically important. Diagnosis of anaphylaxis is currently based on established clinical criteria. Epinephrine (adrenaline) is the first-line medication for anaphylaxis treatment and delay in injecting it contributes to biphasic reactions, hypoxic-ischemic encephalopathy, and fatality. Here, we focus on four important areas of translational research in anaphylaxis: studies of potential new biomarkers to support the clinical diagnosis of anaphylaxis, laboratory tests to distinguish allergen sensitization from clinical risk of anaphylaxis, the primary role of epinephrine (adrenaline) in anaphylaxis treatment, and strengthening the overall evidence base for anaphylaxis treatment. PMID:21668849

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A diffusion criterion of the crystal-liquid phase transition (PT) is proposed according to which the PT begins when the E d/ k b ratio reaches a threshold value of E d( s)/ k b T m, where E d is the self-diffusion energy, k B is the Boltzmann constant, T is the absolute temperature, and E d( s) is the self-diffusion energy in the solid phase at the melting temperature T m. It is shown that this criterion is a generalization of the Lindemann criterion and is applicable both to solids exhibiting normal melting and to those melting with a decrease in the specific volume. Based on the new criterion, it is possible to explain the relation T N < T m, where T N, is the crystallization onset temperature. The results of calculations of the T N/ T m ratio well coincide with experimental data.

UK PubMed Central (United Kingdom)

Materials and MethodsThe genomic effects of tumor-endothelial interactions in cancer are not yet well characterized. To study this interaction in breast...Full Text Available

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Uterine sarcomas are a rare group of neoplasms with aggressive clinical course and poor prognosis. They are classified into four main histological subtypes in order of decreasing incidence: carcinosarcomas,...Full Text Available

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HIV-1 nonsubtype B variants account for the majority of HIV infections worldwide. Drug resistance in individuals who have never undergone antiretroviral therapy can lead to early failure and...Full Text Available

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BACKGROUND: A number of studies have shown that the early mortality following TURP is higher for patients with prostate cancer than those with benign disease. This study examines the effect of the histological...Full Text Available

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BackgroundThe natural history of bronchial preinvasive lesions and the risk of developing lung cancer in patients with these lesions are not clear. Previous studies have treated...Full Text Available

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Total thyroidectomy involving the adjacent structures of the trachea can cause tracheal damage such as early tracheal necrosis. The authors describe the first case of anterior tracheal necrosis following...Full Text Available

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Randomized clinical trials are designed with stopping boundaries to guide data monitoring committees with their decision making concerning ongoing trials. In particular, when extremely positive results...Full Text Available

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BackgroundThere is a lack of studies considering social disparity in oral health emanating from adolescents in low-income countries. This study aimed to assess socio-demographic...Full Text Available

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In rats, expression of the immediate early gene, c-fos observed in the brain following male copulatory behavior relates mostly to the detection of olfactory information originating...Full Text Available

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Dental caries continues to be a common chronic disease among various population groups. Patient care can be improved with detection at the earliest stage. However, current techniques do not...Full Text Available

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IntroductionIrradiation of normal, non-malignant bone during cancer therapy can lead to atrophy and increased risk of fracture at several skeletal sites, particularly...Full Text Available

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The oxytocin and prolactin responses to suckling were measured in 10 women in early (n = 5) and established lactation (n = 5). Oxytocin was released in a pulsatile manner during suckling in all women,...Full Text Available

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Totipotent stem cells have the potential to differentiate into every cell type. Renewal of totipotent stem cells in the germline and cellular differentiation during early embryogenesis rely upon posttranscriptional...Full Text Available

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BackgroundLung cancer diagnosis in tissue material with commonly used histological techniques is sometimes inconvenient and in a number of cases leads to ambiguous conclusions. Frequently...Full Text Available

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We investigated the role of early portal hypotensive pharmacotherapy in preventing the development of portal-systemic shunting in a portal hypertensive model of chronic murine schistosomiasis induced...Full Text Available

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ObjectiveTo evaluate the prognostic significance of adjuvant concurrent chemoradiotherapy-induced neutropenia with survival in patients with squamous cell carcinoma of the uterine...Full Text Available

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Preterm birth is the leading cause of neonatal mortality and morbidity and long-term disability of non-anomalous infants. Previous studies have identified a prior early spontaneous preterm birth as...Full Text Available

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PURPOSE: Visual loss following panretinal photocoagulation was found in the Diabetic Retinopathy and the Early Treatment Diabetic Retinopathy Studies. This study was designed to test the hypothesis...Full Text Available

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The new percutaneous mitral valve repair techniques are at an early stage. Preliminary series show that they are feasible; however, they need to be further evaluated in comparison with contemporary...Full Text Available

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Nineteen of 69 patients undergoing coronary angioplasty required immediate coronary surgery after the procedure. Six of these operations were planned as a result of angioplasty that failed without producing...Full Text Available

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BackgroundThe aim of the present article was to evaluate whether angiogenic parameters as assessed by transvaginal color Doppler ultrasound (TVCD) may predict those prognostic factors...Full Text Available

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Microglia provide immune surveillance for the brain through both the removal of cellular debris and protection against infection by microorganisms and “foreign” molecules. Upon...Full Text Available

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BACKGROUND: Each component of metabolic syndrome (MS) conveys increased cardiovascular disease risk, but as a combination they become much more powerful. Vigorous early management of the syndrome may...Full Text Available

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BackgroundThe proteomics approach termed proteome pattern analysis has been shown previously to have potential in the detection and classification of breast cancer. Here we aimed...Full Text Available

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and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV. J Virol. 2011 May ;85(9):4547-57. Epub 2011 Feb 16 . PubMed Surgical staging of early...

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Background:In recent years, breast cancer (BC) mortality rates have declined, reflecting advances in early detection. Prevention and management of treatment sequelae that could impair...Full Text Available

UK PubMed Central (United Kingdom)

Pancreatic islet transplantation into the liver provides a possibility to treat selected patients with brittle type 1 diabetes mellitus. However, massive early β-cell death increases the number...Full Text Available

Science.gov (United States)

Aquaculture is increasing worldwide, however we have little understanding of its impacts on marine communities. A critical element of many marine communities are seagrasses, a group of globally distributed marine angiosperms that are drivers of many abiotic and biotic processes in estuarine and mari...

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Suppressed IL-12 production and maladaptive immune activation, both of which are ameliorated by successful highly active antiretroviral therapy (HAART), are thought to play important roles in the immunopathogenesis...Full Text Available

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Assessment of subtle changes in the primary macromolecular components of cartilage, proteoglycan (PG) and collagen, is critical for the diagnosis of early stages of osteoarthritis (OA), but...Full Text Available

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ContextFatigue is the most common sequela among non-small cell lung cancer (NSCLC) survivors 1–6 years post-treatment and is associated with functional limitations.Full Text Available

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Ammonoids and conodonts, being characterized by exceptionally high background rates of origination and extinction, were vulnerable to global environmental crises, which characteristically intensified...Full Text Available

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The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site. Elk-1 is associated with...Full Text Available

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A rise in blood pressure associated with oral contraceptives is well established but the frequency with which it develops is not known. Early results from a controlled long-term prospective study have...Full Text Available

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Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine (TCM). As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransformation...Full Text Available

International Nuclear Information System (INIS)

Early effects of boron neutron capture therapy (BNCT) on malignant glioma are characterized by reduction of the enhancement area and regression of the peritumoral edema radiologically. The aim of this study was to investigate the early histological changes of tumors and inflammatory cells after BNCT in the rat brain. Rats were treated with BNCT using boronophenylalanine (BPA) 7 days after implantation of C6 glioma cells. The tumors were assessed with magnetic resonance imaging and histopathological examination at 4 days after BNCT. The mean tumor volumes were 39#+-#2 mm"3 in the BNCT group and 134#+-#18 mm"3 in the control group. In the BNCT group, tumor cells showed a less pleomorphic appearance with atypical nuclei and mitotic figures. The Ki-67 labeling index was 6.5%#+-#4.7% in the BNCT and 35%#+-#3.8% in the control group. The reactions of the inflammatory cells were examined with ED-1 as macrophage marker and OX42 as microglia marker. ...

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IntroductionRadiotherapy outcomes might be further improved by a greater understanding of the individual variations in normal tissue reactions that determine tolerance. Most published...Full Text Available

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Non-cemented femoral fixation in hip arthroplasty has become the standard of practice in the USA. However, recent literature has brought attention to an increasing incidence of periprosthetic femur...Full Text Available

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IntroductionFlow diversion is a new approach to the endovascular treatment of intracranial aneurysms which uses a high density mesh stent to induce sac thrombosis. These devices...Full Text Available

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Background:The present study measured longitudinal changes in bone turnover markers in elderly patients with vertebral fracture and investigated the relationship among bone turnover...Full Text Available

International Nuclear Information System (INIS)

Spinal Ewing's sarcomas are rare and cause problems in differential diagnosis. The radiologic, nuclear medicine and CT findings in two children with histologically proven Ewing's sarcoma are presented and problems in differential diagnosis discussed. Biopsy should be done early. (orig.).

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OBJECTIVEPrevious studies showed that genetic deletion or pharmacological blockade of the receptor for advanced glycation end products (RAGE) prevents the early structural changes...Full Text Available

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In summer 2000, the Cushing/Whitney Medical Library at Yale University began a demonstration project to digitize classic articles in neurosurgery from the late 1800s and early 1900s. The objective of...Full Text Available

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Ripening of `Tydeman's Early' apples (Malus sylvestris L.) assessed by the occurrence of the respiratory climacteric was delayed by succinic acid 2,2-dimethyl hydrazide (B-9) but not...Full Text Available

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Premature circuit clotting is a major problem in daily practice of continuous renal replacement therapy (CRRT), increasing blood loss, workload, and costs. Early clotting is related to bioincompatibility,...Full Text Available

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This paper reviews the development of cerebral scintigraphy from its early days of planar imaging with simple technetium-99m labelled compounds to the recent revival of the technique in the form of...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Research on Be stars from the early work of Merrill and Struve to the present is reviewed, including recent observations from space. A number of models which have been proposed to explain the Be phenomenon are discussed, and the evolutionary status of Be stars is considered. 126 references.

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BackgroundIn vitro data suggest that changes in myocardial substrate metabolism may contribute to impaired myocardial function in diabetic cardiomyopathy (DCM)....Full Text Available

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Adaptive image processing is one of the most important techniques in visual information processing, especially in early vision such as image restoration, filtering, enhancement, and segmentation. This work focuses on applications of advanced CI techniques in image processing applications

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A method is presented to derive the absolute dimensions of early-type detached binaries by combining the observed parameters with results of evolutionary computations. The method is used to obtain the absolute dimensions of nine close binaries. We find that most systems have an initial masss ratio near 1.

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IntroductionVarious multigene predictors of breast cancer clinical outcome have been commercialized, but proved to be prognostic only for hormone receptor (HR) subsets overexpressing...Full Text Available

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Thiamin(e), also known as vitamin B1, is now known to play a fundamental role in energy metabolism. Its discovery followed from the original early research on the ‘anti-beriberi factor’...Full Text Available

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Methylphenidate (MPH) is commonly prescribed in childhood and adolescence for the treatment of attention–deficit/hyperactivity disorders. In rodents, MPH exposure during preadolescence...Full Text Available

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BackgroundPathophysiological mechanisms involved in amyotrophic lateral sclerosis (ALS) are complex and none has identified reliable markers useful in routine patient evaluation....Full Text Available

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Transplantation has emerged as the therapy of choice for many patients with end organ failure. One of the major goals is to tailor immunosuppressive therapy to the individual needs of every patient to balance the risk for rejection and over-immunosuppression. This will require diagnostic tools that can detect harmful processes in the allograft early, and that can be measured repeatedly. This review will consider recent advances in our understanding of the molecular nature of these processes and how this information is being utilized to design novel diagnostic assays to non-invasively monitor allografts. Highlighted is the need for large-scale prospective multi-centre studies to validate assays that show early promise in single centre studies.

Energy Technology Data Exchange (ETDEWEB)

The fact that South Africa had no commercially significant deposits of crude oil necessitated the early development of production of gasoline from coal which was present in abundance in low to medium grade in thick seams, the development of the process since the early 1950s is discussed. Both the Fischer Tropsch and Lurgi processes are used, and three large plants named Sasol One, Two, and Three have been completed. A flow diagram for the Lurgi process as used in these plants is included. Typical products and their properties resulting from the Sasol-type Synthol operation are presented in tabular form. Marketing considerations and economics of production of the Sasol products are discussed briefly. (BLM)

International Nuclear Information System (INIS)

Gallium imaging is increasingly being used for the early detection of complications in patients with AIDS. A 26-year-old homosexual man who was HIV antibody positive underwent gallium imaging for investigation of possible Pneumocystis carinii pneumonia. Widespread cutaneous focal uptake was seen, which was subsequently shown to be due to mycobacterium avium-intracellulare (MAI) septicemia. This case demonstrates the importance of whole body imaging rather than imaging target areas only, the utility of gallium imaging in aiding the early detection of clinically unsuspected disease, and shows a new pattern of gallium uptake in disseminated MAI infection.

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Total skin electron beam therapy (TSEB) was used in the treatment of 33 patients with lymphoma and 13 patients with leukemia involving extensive segments of the skin surface. Twenty-two of 23 had lesions as a primary manifestation of lymphoma (primary cutaneous lymphoma-PCL) and 11 developed cutaneous lesions following disseminated nodal lymphoma (secondary cutaneous lymphoma-SCL). A once weekly fractionation scheme was employed to irradiate the entire skin surface with 3.5 to 4 MeV electron beam from a 6 MeV linear accelerator. During each weekly session, 400 rad were delivered to the entire skin and a complete course consisted of 4-6 consecutive weekly sessions. The majority of patients have been previously treated elsewhere for various periods and all patients have been at risk for a median of 12 months, range from 12-117 months following TSEB. Striking predominance of the diffuse pattern (76%) was demonstrated in both the PCL and SCL. There was extracutaneous involvement in 63% ...

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The gender-specific expression pattern of aromatase and 5alpha-reductases (5alpha-R) during brain development provides neurons the right amount of estradiol and DHT to induce a dimorphic organization of the structure. Polychlorinated biphenyls (PCBs) are endocrine disruptive pollutants; exposure to PCBs through placental transfer and breast-feeding may adversely affect the organizational action of sex steroid, resulting in long-term alteration of reproductive neuroendocrinology. The study was aimed at: a) evaluating the hypothalamic expression of aromatase, 5alpha-R1 and 5alpha-R2 in fetuses (GD20), infant (PN12), weaning (PN21) and young adult (PN60) male and female rats exposed to PCBs during development; b) correlating these parameters with the time of testicular descent, puberty onset, estrous cyclicity and copulatory behavior; c) evaluating possible alterations of some non reproductive behaviors (locomotion, learning and memory, depression/anxiety behavior). A ...

International Nuclear Information System (INIS)

The Median Tectonic Zone (MTZ) of New Zealand is a generally north trending belt of Mesozoic subduction related I-type plutonic, volcanic, and sedimentary rocks in South Island and Stewart Island that separates Permian strata of the Eastern Province Brook Street Terrane from lower to mid Gondwana margin assemblages of the Western Province. High precision isotope dilution U/Pb ages of zircons from 30 rocks are reported. Pre-digestion leaching of zircon in hydrofluoric acid yielded significantly more concordant residues by removing common Pb and dissolving more soluble high-U domains that have been more affected by relatively recent Pb loss. The results show that MTZ magmatism ranges in age from at least Early Triassic to Early Cretaceous (247-131 Ma), with a pronounced gap in the Middle Jurassic. Triassic plutons tend to occur on the eastern side of the MTZ, and they intrude volcanic/sedimentary sequences of the MTZ in Nelson and eastern ...

Energy Technology Data Exchange (ETDEWEB)

The usefulness of helical CT early phase images optimized by the SmartPrep method for evaluation of wall invasion by colorectal cancer was investigated. Between August 1997 and September 1998, CT was performed to evaluate the primary tumor and local extension in 10 consecutive patients with colorectal cancer confirmed by barium enema- and/or colonoscopy. Early-phase images were acquired by using SmartPrep application software. This method allows the optimal scan delay time to be obtained by continuous monitoring of increases in CT values after injection of contrast medium. Sections of the surgical specimens, close to the same plane as the CT images, and of the same slice thickness, were analyzed histopathologically. All 10 cancers, regardless of size, showed strong enhancement on the early-phase images (81.4-112 HU, mean: 95.1 HU). The strongly enhanced image areas on CT corresponded to the primary cancer areas on ...

International Nuclear Information System (INIS)

We derive stellar masses, ages, and star formation histories (SFHs) of massive early-type galaxies in the z = 1.237 RDCS1252.9-2927 cluster and compare them with those measured in a similarly mass-selected sample of field contemporaries drawn from the Great Observatories Origin Deep Survey South Field. Robust estimates of these parameters are obtained by comparing a large grid of composite stellar population models with 8-9 band photometry in the rest-frame near-ultraviolet, optical, and IR, thus sampling the entire relevant domain of emission of the different stellar populations. Additionally, we present new, deep U-band photometry of both fields, giving access to the critical far-ultraviolet rest frame, in order to empirically constrain the dependence of the most recent star formation processes on the environment. We also analyze the morphological properties of both samples to examine the dependence of their scaling relations on their mass and environment. We ...

Science.gov (United States)

Based on the view that major changes in the social and economic context in the United States require major policy changes related to early childhood education, this paper examines the factors supporting public policy changes and how advocates for change in early childhood education might incorporate effective strategies. The paper is presented in two parts. Part 1 reviews the research on state policy settings and the factors that tend to support policy change. This part focuses attention on the ways that state policymakers appear to learn from what is going on elsewhere and incorporate new ideas into their policy agendas. Several strategic implications for advocates of policy change are presented, such as brainstorming a list of potential obstacles to the introduction of a policy innovation or shaping the debate so the public will support change. Part 2 of the paper takes these general strategic implications and considers their relevance to ...

International Nuclear Information System (INIS)

Reproductive parameters were monitored in 50 post-partum Bos indicus x Bos taurus animals located on four farms in two ecological zones of Panama. Progesterone (P_4) concentrations were measured in four of these animals twice a week and their reproductive organs palpated per rectum once a week until 60 days post-artificial-insemination or post-natural-service. The other 46 cows were palpated for early pregnancy between days 45 and 60 post-service. The mean P_4 concentration in cows with palpable corpora lutea (CL) was 10.3#+-#4.0 nmol/L; when no Cl were detected, the mean P_4 level was 2.2#+-#1.6 nmol/L. Of the 46 animals palpated for early pregnancy, 36 (70%) were found to be pregnant, one (2%) exhibited early embryonic death and one (2%) aborted; the other eight cows (17%) were anoestrous. The mean P_4 concentration in pregnant cows was 11.9#+-#4.0 nmol/L and the calving to conception interval was 148 days. (author). 13 ...

CERN Document Server

We present the results of an isophotal shape analysis of three samples of galaxies in the Coma cluster. Quantitative morphology, together with structural and photometric parameters, is given for each galaxy. Special emphasis has been placed on the detailed classification of early-type galaxies. The three samples are: i) a sample of 97 early-type galaxies brighter than m_B = 17.00 falling within one degree from the center of the Coma cluster; these galaxies were observed with CCD cameras, mostly in good to excellent resolution conditions; ii) a magnitude complete sample of 107 galaxies of all morphological types down to m_B = 17.00 falling in a circular region of 50 arcmin diameter, slightly offcentered to the North-West of the cluster center; the images for this and the next sample come from digitized photographic plates; iii) a complete comparison sample of 26 galaxies of all morphological types down to m_R = 16.05 (or m_B \\simeq 17.5), also ...

Environmental Research Database

ObjectivesThe main objective of this study is to address the following specific questions: 1. Are the delayed effects of poor early diet on whole organism performance and senescence contingent on, or exacerbated by, the subsequent occurrence of compensatory growth? 2. Does the rate of growth influence levels of resting metabolism and/or oxidative stress, and if so, for how long does this persist? 3. How are the levels of early nutrition, growth, resting metabolism and oxidative stress linked to the lev [continued...]DescriptionIt is now widely appreciated that, while animals may appear to recover from periods of poor food quality or quantity experienced in early development, adverse effects may occur later in adult life. Such effects can influence the performance of complete cohorts of animals, and have important consequences for population dynamics. The reasons why such delayed effects occur across the animals' lifetimes ...

Science.gov (United States)

In the present political climate, politicians are singling out children's programs and services for budget cuts. The need for teacher education programs to prepare early childhood teachers as children's advocates is becoming ever more evident. For years, the National Association for the Education of Young Children has called for greater involvement of early childhood educators as advocates for programs and services that promote children's health and education. In teacher education programs, however, this call has largely gone unheeded. The purpose of this article is to discuss the importance of involving teacher candidates in advocacy activities and policy research, the obstacles that teacher educators can face when incorporating advocacy components into their teacher education courses and programs, and resources and strategies they can use. This discussion builds upon a motivation-obstacles-resources framework developed for adoption of ...

Energy Technology Data Exchange (ETDEWEB)

This presentation outlined the corporate history of the Ohmega Group, a small company from Gaspe, Quebec which offers consulting services to the automation and telecommunication sector. It was created in 1982 and has been involved with the wind power industry since 1996. The main services provided by Ohmega Group include electrical and mechanical construction and maintenance services. This paper also reviewed the benefits of using Supervisory Control and Data Acquisition (SCADA) systems in the wind power industry to monitor, control and collect data from wind turbines. The Ohmega Group has provided consulting services to Cartier Wind Energy Inc., a company that was awarded several wind turbine projects by Hydro-Quebec Distribution. The Ohmega Group applied the SCADA system at the Baie des Sables, Anse a Valleau and Carleton wind turbine arrays. The typical architecture of SCADA systems on a wind farm was presented along with Hydro-Quebec's specifications for data acquisition. ...

Energy Technology Data Exchange (ETDEWEB)

Total hemispherical emittance was measured for the SP-100 reactor fuel cladding alloy (Nb-l% Zr). Based on a standard test method (ASTM C 835-82), experiments were conducted on a reference sample of oxidized stainless steel and then on a sample of actual cladding. The sample is heated in a vacuum by passing DC current through it until reaching equilibrium. Measurements are made of the electrical power dissipated in the sample and of the surface temperature. Using the Stefan-Boltzmann Law and some key assumptions concerning conductive and radiative heat transfer, the measured quantities are used to calculate emittance. Calculated values for unoxidized cladding range from 0.159 +/- 5.35% at 913 K to 0.200 +/- 4.51% at 1091 K. Highest value measured after onset of visible oxidation was 0.339 +/- 3.92% at 1269 K.... SP-100, Reactor, Emittance, Niobium, Fuel cladding, Emissivity.

Science.gov (United States)

Simple hydroxamic acids have been shown to have useful applications in an Advanced Purex process for the reprocessing of irradiated nuclear fuel. They are especially suited to the separation of neptunium (IV) from uranium (VI) by the selective formation of a hydrophilic complex with Np(IV). U(VI) extraction in to 30% tributyl phosphate is unaffected. However, they have also been shown to be very fast reducing agents for Np(VI). The timescales of the reduction have been defined under a range of typical Purex Process conditions although the accurate determination of the reaction kinetics was not possible due to the rapidity of the reaction. U(VI) was shown not to be reduced. Therefore, Np(VI) can be efficiently reductively stripped when solvent phase (30% tributyl phosphate in odourless kerosene) solutions of Np(VI) and U(VI) are contacted with aqueous phase hydroxamic acid solutions. The slow reduction of plutonium (IV) to Pu(III) has also been observed and this is apparently enhanced ...

International Nuclear Information System (INIS)

The swelling and in-reactor creep behaviors of the PCA alloy have been determined from the irradiation of pressurized tube specimens in the FFTF reactor. These data have been obtained to a peak neutron fluence corresponding to approximately 80 dpa in the FFTF reactor for irradiation temperatures between 400 and 750"0C. Diametral measurements performed on the unstressed specimens indicate the possible onset of swelling in the PCA alloy for irradiation temperatures between 400 and 550"0C and at a neutron fluence corresponding to #approx#50 dpa. The creep data suggest a non-linear fluence dependence and linear stress dependence (for hoop stresses less than 100 MPa) which is consistent with the in-reactor creep behavior of many cold worked austenitic stainless steels. These PCA creep data are compared to available 316 SS in-reactor creep data. The in-reactor creep strains for PCA are significantly less than observed in 20% cold worked 316 SS over the temperature ranges ...

International Nuclear Information System (INIS)

Nitrogen-rich Ca-#alpha#-sialon ceramics, prepared with CaH_2 as one of the starting powders, were compressively deformed in spark plasma sintering equipment. Compared with the oxygen-rich Ca-#alpha#-sialons, increasing onset deformation temperatures (about 150 K higher) were observed for nitrogen-rich Ca-#alpha#-sialons deformed at a rate of 2 x 10"-"3 s"-"1. High hardness (H_V_1_0 = 18-20 GPa) and toughness (K_I_C = 4-7 MPa m"1"/"2) were maintained after the deformation. Anisotropic grain growth was found to take place during deformation, resulting in anisotropic microstructures, containing coarse and elongated grains. The observed differences in deformation behaviour and properties between nitrogen-rich and oxygen-rich Ca-#alpha#-sialons are, as indicated by transmission electron microscopy and electron energy loss spectroscopy analysis, attributed to the presence of reduced amounts of a nitrogen-rich grain-boundary glass phase.

International Nuclear Information System (INIS)

Combustion noise, knock and ignition limits data are measured and presented for a dual fuel engine running on dual fuels of Diesel and three gaseous fuels separately. The gaseous fuels used are liquefied petroleum gas, pure methane and compressed natural gas mixture. The maximum pressure rise rate during combustion is presented as a measure of combustion noise, and the knocking and ignition limits are presented as torque output at the onset of knocking and ignition failure. Experimental investigation on the dual fuel engine revealed the noise generated from combustion, knocking and ignition limits for all gases at different design and operating conditions. A Ricardo E6 Diesel version engine is converted to run on dual fuel of Diesel and the tested gaseous fuel and is used throughout the work. The engine is fully computerized, and the cylinder pressure data, crank angle data and engine operating variables are stored in a PC for off line analysis. The effects of ...

Energy Technology Data Exchange (ETDEWEB)

When one deals with a plasma column whose radius a is much smaller than its length L, one can think of it as of a thin filament whose kink instability can be adequately described simply by a 2D displacement vector, {xi}{sub x} = {xi}{sub s}(z,t); {xi}{sub y} = {xi}{sub y}(z,t). Details of the internal structure of the column such as the current, density, and axial flow velocity distribution would be lumped into some phenomenological parameters. This approach is particularly efficient in the problems with non-ideal (sheath) boundary conditions (BC) at the end electrodes, with the finite plasma resistivity, and with a substantial axial flow. With the sheath BC imposed at one of the end-plates, we find instability in the domain well below the classical Kruskal-Shafranov limit. The presence of an axial flow causes the onset of rotation of the kink and strong axial ''skewness'' of the eigenfunction, with the perturbation amplitude ...

Energy Technology Data Exchange (ETDEWEB)

This study presents a dynamic analysis of a rotor supported by two turbulent flow model journal bearings and lubricated with couple stress fluid under nonlinear suspension. The dynamics of the rotor center and bearing center is studied. The dynamic equations are solved using the Runge-Kutta method. The analysis methods employed in this study is inclusive of the dynamic trajectories of the rotor center and bearing center, power spectra, Poincare maps and bifurcation diagrams. The maximum Lyapunov exponent analysis is also used to identify the onset of chaotic motion. The results show that the values of dimensionless parameters l* strongly influence dynamic motions of bearing and rotor centre. It is found that couple stress fluid improve the stability of the system when l* > 0.4 even if the flow of this system is turbulent. We also demonstrated that the dimensionless rotational speed ratios s and the dimensionless unbalance parameter {beta} are also ...

Energy Technology Data Exchange (ETDEWEB)

Transmission electron microscopy studies on solution-annealed Alloy 800 revealed small (100-200 nm), spherical-shaped titanium carbide (face centered cubic structure) and large (200 nm-5 {mu}m), faceted titanium nitride (hexagonal structure) particles randomly distributed in the austenite matrix. The volume fraction of former particles was found to be greater than that of the latter. Corrosion studies of the alloy in acidic, chlorides and acidic chloride environments at room temperature indicated that the passivity of Alloy 800 was adversely affected by the addition Cl{sup -} ions. X-ray photoelectron spectroscopy revealed that the surface film formed on the alloy at the onset of passivity consisted of Cr{sup 3+} (as Cr{sub 2}O{sub 3}), without any Fe{sup 3+}/Fe{sup 2+} or Ni{sup 2+}. Scanning electron microscopy studies indicated initiation of pitting at large, faceted particles, not at small, spherical-shaped ones.

Science.gov (United States)

The deflagration-to-detonation transition of low density (0.88 g/cc) PETN during initiation by both an exploding bridgewire and laser driven source is being studied using both laser interferometry and streak photography. Cutback experiments using VISAR have confirmed a 1.0 mm run-distance to detonation in low density PETN powder. In a detonation system using a combination of low and high density powders, an apparent center of initiation (COI) analysis of streak data has yielded a surprisingly similar result. This data suggests that a compaction of low density powder to near theoretical maximum density (TMD) occurs before the onset of detonation, which is consistent with work done previously.^1 Additionally, data analysis shows that although function time increases significantly with decreasing firing voltage, the apparent COI changes very little. This indicates that the detonation criteria is not dependant upon the rate of deflagration, but on a volume of material ...

Science.gov (United States)

Endoreduplication represents a cell cycle variant during which multiple rounds of DNA replication occur without subsequent chromosome separation and cytokinesis, resulting into a cellular increase of the DNA content. Although the DNA ploidy level of cells is controlled by external stimuli such as light, currently limited knowledge is available on how environmental signals regulate the endoreduplication cycle at the molecular level. Previously, we have demonstrated that the conversion from the mitotic cell cycle into an endoreduplication cycle is mediated by the atypical E2F transcription factor DEL1 that operates as a repressor of endocycle onset. Here, we identified DEL1 as a transcriptional target of the classical E2Fb and E2Fc transcription factors that antagonistically control DEL1 transcript levels through competition for a single E2F cis-acting binding site. Correspondingly with the reported opposite effect of light on the E2Fb and E2Fc protein levels, the ...

Energy Technology Data Exchange (ETDEWEB)

The infrastructure of the Mexican southeastern coastal zone is affected by corrosion problems which are due, mainly, to the construction bad practices and to the aggressive environmental agents (temp., Relative Humidity, chlorides). The first actions for knowing and controlling them have been taken on the coast of Progreso, Yucatan. Cylinders of solid concrete and others with an embedded rebar were constructed and exposed to the marine environment studying different variables like w/c ratio, time of curing, coated and uncoated rebars, chlorides and CO{sub 2} penetration and place of exposure with respect to the seashore. The cylinders were tested through corrosion potential and polarization resistance measurements in order to detect, in a first stage, the onset and propagation stages of the corrosion processes and to correlate the apparent corrosion current density (Icorr.) with the chloride concentration in the rebar surface. These results are discussed and ...

International Nuclear Information System (INIS)

The aim of this study was to assess the influence of the normal menstrual cycle and of menopause on the gastric emptying rate of solids. Gastric emptying was studied in 15 premenopausal and ten postmenopausal women with an isotopic technique after the ingestion of a radiolabelled test meal. Premenopausal women were studied twice: Within 1 week prior to menses and again 1 week after onset of menses. Postmenopausal women were studied only once. The emptying curves of the solid component of the meal fitted a linear model. The half-emptying time was 78#+-#5 min during the follicular phase, 75#+-#7 min during the luteal phase and 76#+-#6 min in postmenopausal women (differences not statistically significant). The mean percentages of the meal retained in the stomach at different time intervals were also similar in the three groups. These results suggest that the menstrual cycle does not influence the gastric emptying rate of solids, which remains unchanged in relation to ...

Energy Technology Data Exchange (ETDEWEB)

The diagnosis of dialysis-related amyloid (AB-amyloid) has been based usually on clinical and radiological criteria. Following the discovery that beta 2-microglobulin was the major protein of this amyloid, we isolated and radiolabelled uremic plasma beta 2-microglobulin. After intravenous injection, gamma-camera images of selected joint areas were obtained from 42 patients who were on regular hemodialysis therapy. Positive scans involving the shoulder, hip, knee and carpal regions were found in 13 of 14 patients treated for more than 10 years and 10 of 16 patients treated for 5 to 10 years. Patients treated for less time had negative scans. Specificity was indicated by negative scans in non-amyloid inflammatory lesions in control hemodialysis patients. Up to 48-fold tracer enrichment was detected in excised AB-amyloid containing tissue as compared to amyloid-free tissue. These findings suggest that circulating radiolabelled beta 2-microglobulin is taken up by the amyloid deposits. This ...

International Nuclear Information System (INIS)

Measuring gene expression using microarrays is relevant to many areas of biology and medicine, such as follow up of developmental stages and diseases onset, and treatment study. Since there can be tens of thousands of distinct probes on an array, each micro array experiment can accomplish the equivalent number of genetic tests in parallel. Arrays have therefore dramatically accelerated many types of investigations. For example, microarrays can be used to identify stress response genes by comparing gene expression in challenged versus normal cells. In the Molecular and Cellular Biology lab (MCB), the micro array experiments are performed within the Genomic Platform, fully equipped to analyse either the behaviour of bacteria during long space flight, the effect of low dose ionising radiation on the developing organism in mice, or the human individual radiation sensitivity. For the low dose effect, two main stages of development are of interest; 1) the gastrula stage ...