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1

Peripheral degenerative joint diseases  

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Full Text Available Osteoarthritis, a degenerative joint disease, is the most commonrheumatic disorder mainly in a geriatric population. Manifestationsare pain, stiffness and functional loss in the affected joint.According to etiology it is classifi ed as primary (or idiopathicand secondary. Some risk factors for disease development aregenetics, race, age, sex, obesity, occupational activities andarticular biomechanics. Pathogenesis is the same for any cause orlocalization, being catabolic alterations, with synthesis, inhibitionand reparing intent of the cartilage matrix. Metalloproteinases andcytokines (IL-1,IL-6,TNF-? actions promote infl ammatory reactionand cartilage degradation. Pain, the most important symptom,does not correlate with radiologic fi ndings. Peripheral osteoarthritisoccurs predominantly in the knee, hip and hand. Diagnosis is basedon clinical features, laboratorial tests and radiological changes.Rheumatological associations’ guidelines for treatment includenon-pharmacologic (education, physiotherapy, assistive devices,and pharmacologic (analgesics, anti-infl ammatory drugs therapyand surgery. Arthroplasty seems to work better than medicines, butshould be used if other treatments have failed.

Nilzio Antonio da Silva

2008-03-01

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Etiology, pathophysiology and conservative management of degenerative joint disease  

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Etiology of degenerative joint diseases Etiology of degenerative joint diseases is still not clearly understood and there is no specific management for this group of diseases. Various pathological conditions cause damage of the articular cartilage and lead to clinically and radiographically recognized impairment. Biomechanical, metabolic, genetic factors inflammation and other risk factors contribute to development of osteoarthrosis. Pathophysiology of degenerative joint diseases Osteoarthros...

Jandri? Slavica

2002-01-01

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Is running associated with degenerative joint disease?  

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Little information is available regarding the long-term effects, if any, of running on the musculoskeletal system. The authors compared the prevalence of degenerative joint disease among 17 male runners with 18 male nonrunners. Running subjects (53% marathoners) ran a mean of 44.8 km (28 miles)/wk for 12 years. Pain and swelling of hips, knees, ankles and feet and other musculoskeletal complaints among runners were comparable with those among nonrunners. Radiologic examinations (for osteophytes, cartilage thickness, and grade of degeneration) also were without notable differences among groups. They did not find an increased prevalence of osteoarthritis among the runners. Our observations suggest that long-duration, high-mileage running need to be associated with premature degenerative joint disease in the lower extremities

1986-03-07

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Degenerative joint disease in weight-lifters. Fact or fiction?  

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A clinical and radiological study of upper and lower limb joints was carried out on 25 experienced weight-lifters to identify the extent of degenerative joint disease (Osteoarthrosis) produced by this sport. Although significant degenerative changes were found in five lifters (20%). This figure is not greater than that found in the general population within the age group studied. There were more degenerative changes found in Olympic style weight-lifters (30.7%) than in power lifters (8.3%). T...

Fitzgerald, B.; Mclatchie, G. R.

1980-01-01

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Etiology, pathophysiology and conservative management of degenerative joint disease  

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Full Text Available Etiology of degenerative joint diseases Etiology of degenerative joint diseases is still not clearly understood and there is no specific management for this group of diseases. Various pathological conditions cause damage of the articular cartilage and lead to clinically and radiographically recognized impairment. Biomechanical, metabolic, genetic factors inflammation and other risk factors contribute to development of osteoarthrosis. Pathophysiology of degenerative joint diseases Osteoarthrosis is characterized by progressive erosion of articular cartilage and bone overgrowth at the joint margins. Cartilage integrity requires balance between synthesis and degradation of matrix components. Chondrocytes react to various mechanical and chemical stresses in order to stabilize and restore the tissue. Failures in stabilizing and restoring the tissue lead to cartilage degeneration that may be irreversibile. For better understanding of conservative management of degenerative joint diseases it is important to know the impact of pathophysiology mechanisms on development of degenerative joint diseases. There is great variability in the rate of progression of erosive processes in articular cartilage in clinical radiographic signs and course of the disease. This is in relation with many factors, as well as with management and response to therapy. Treatment of degenerative joint diseases Treatment should vary depending on the severity of disease and patient's expectations and level of activity. Besides analgesic and anti-inflammatory drugs, conventional and not conventional treatment and techniques can be used for management of osteoarthrosis. Physical therapy and exercises are very important for maintaining muscle strength, joint stability and mobility, but should be closely monitored for optimal efficacy.

Jandri? Slavica

2002-01-01

6

Self-repair in degenerative joint disease.  

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This study presents a method for treating and structurally improving articulations affected by degenerative joint disease (DJD). The focus of this analysis is on two groups of patients: the first comprised patients over eighty years old, and the second comprised patients aged 45 to 55 years. The first group was a high surgical risk and both had been nonresponders to current conservative therapies. Scholars like Davis, Filatov, and Cerletti have been studying and using the regenerative properties of placenta, amnios and other nonvital tissues since the early 1900s. These pioneering studies have opened a new track for tissue renewal. More recently, the new biological knowledge about extracellular nucleic acids, growth factors (GF) (as by-products of trauma response), and heat shock proteins (Hsp) has helped research even further. Building on those experiences, we have developed a regenerative gel obtained with distressed, processed blood, polydeoxyribonucleotides (Pdrn), and a thickening substance. The objective was to stimulate the local innate stem cells with our gel in order induce tissue repair. From 2003 until 2009, we treated 948 patients. As mentioned, the first group comprided of 86 ultra-octogenarian patients with severe osteoarthritis (OA) of the hip and/or knee, and the second group comprised of 90 younger patients (around 50 years old) affected by the same disease. Treated patients have been clinically and radiologically evaluated with a follow-up of 6 to 48 months. Results show a statistically significant improvement in terms of pain and joint mobility, sometimes coupled with clear improvement in radiological imaging. Follow-up shows encouraging data in terms of clinical stability over time. During the study, we encountered virtually no side effects, adverse reactions, or toxicity. Currently the pharmacological treatment of DJD is palliative, though toxicity and side effects of the drugs remain problematic. Patients who can be operated on conclude their trial with a prosthesis followed by a long rehabilitation period. This study presents a new methodological approach to the treatment of DJD based on tissue regeneration and restoration resulting in a positive clinical resolution. PMID:23330827

Di Nicola, Valerio; Di Nicola, Renato

2012-12-01

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Pedicle marrow signal intensity changes in the lumbar spine: a manifestation of facet degenerative joint disease  

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Objective. Signal intensity changes in lumbar pedicles, similar to those described in vertebral body endplates adjacent to degenerated discs, have been described as an ancillary sign of spondylolysis on MRI. The purpose of this study was to determine whether pedicle marrow signal intensity changes also occur in association with facet degenerative joint disease.Design. Eighty-nine lumbar spine MRI examinations without spondylolysis were reviewed for marrow signal intensity changes in pedicles and vertebral bodies as well as for facet degenerative joint disease.Results. Five percent (46/890) of lumbar pedicles in 23 patients had marrow signal intensity changes. Ninety-one percent (42/46) of the abnormal pedicles had adjacent degenerative joint disease of the facets, while only 21% (189/890) of normal pedicles had adjacent facet degenerative joint disease (p<0.001). Eighty-nine percent (41/46) of the pedicles with marrow signal intensity changes had adjacent degenerative disc disease.Conclusions. Pedicle marrow signal intensity changes are not a specific sign of spondylolysis; they are commonly seen with adjacent facet degenerative joint disease in the absence of spondylolysis. Pedicle marrow signal intensity changes are probably a response to abnormal stresses related to abnormal motion or loading caused by the degenerative changes in the spinal segment. (orig.)

Morrison, J.L.; Kaplan, P.A.; Dussault, R.G.; Anderson, M.W. [Dept. of Radiology, Univ. of Virginia Health System, Charlottesville, VA (United States)

2000-12-01

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Stress radiographs in the evaluation of degenerative femorotibial joint disease  

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Thirty-eight osteoarthrotic knees were examined to assess the widths of the femorotibial joint spaces. Radiographs were exposed with the patient lying, in a standing position, and with an adduction and abduction force. Forced compression of the osteoarthrotic joint compartment caused, on average, 18% greater narrowing than when loading it in the standing position. Compared to the joint space at rest, the non-weight-bearing compartment widened by 16% in the standing position and narrowed by 20% when stress was applied. Furthermore, the results showed an increase in laxity proportional to the degree of arthrosis. Stress radiographs significantly display the real cartilage width of both joint compartments. Knowledge of the condition of the articular cartilage in the non-weight-bearing compartment is important when considering a transfer of loading stresses by means of osteotomy. (orig.)

1987-01-01

9

Stress radiographs in the evaluation of degenerative femorotibial joint disease.  

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Thirty-eight osteoarthrotic knees were examined to assess the widths of the femorotibial joint spaces. Radiographs were exposed with the patient lying, in a standing position, and with an adduction and abduction force. Forced compression of the osteoarthrotic joint compartment caused, on average, 18% greater narrowing than when loading it in the standing position. Compared to the joint space at rest, the non-weight-bearing compartment widened by 16% in the standing position and narrowed by 20% when stress was applied. Furthermore, the results showed an increase in laxity proportional to the degree of arthrosis. Stress radiographs significantly display the real cartilage width of both joint compartments. Knowledge of the condition of the articular cartilage in the non-weight-bearing compartment is important when considering a transfer of loading stresses by means of osteotomy. PMID:3423831

Tallroth, K; Lindholm, T S

1987-01-01

10

Degenerative Nerve Diseases  

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Degenerative nerve diseases affect many of your body's activities, such as balance, movement, talking, breathing, and heart function. Many ... viruses. Sometimes the cause is not known. Degenerative nerve diseases include Alzheimer's disease Amyotrophic lateral sclerosis Friedreich's ...

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Influence of spinal degenerative joint disease on BMD measurement by QCT and DXA  

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Objective: To assess the impact of spinal degenerative joint disease (DJD) changes on bone mineral density (BMD) measured by quantitative CT (QCT) and dual X-ray absorptiometry (DXA) in a group of relative old population. Methods: Lateral (T4-L4) and anterior posterior (L1-L4) spinal radiographs in 201 subjects were reviewed for evaluation of fracture and DJD. The subjects ranged in age from 45-80 years (mean age 59.6 +- 0.8 years). Exclusion criteria included history of any bone disease or condition know to affect bone metabolism. The severity of DJD was graded as 0, 1 or 2 on the spinal lumbar film, except for DJD with vertebral osteophytes which was graded from 0 to 3. Twenty-five out of the 201 subjects were diagnosed with vertebral fractures by visual inspection using the semiquantitative method. Spinal BMD was measured by both QCT and DXA, including posteroanterior DXA (PA-DXA), lateral DXA (L-DXA), and mid lateral DXA (ML-DXA). Results: There were no significant differences in BMD measured by QCT in the 176 non-fractured subjects with and without DJD (P > 0.05). BMD measured by PA-DXA was significantly higher in subjects with DJD changes than those without, particularly when osteophytes were presented at the vertebral bodies and facet joints (P 0.05). Conclusion: QCT is superior to PA-DXA, L-DXA, and ML-DXA in detecting bone loss in patients with DJD. For subjects with severe DJD, BMD assessment using QCT may be advisable

2002-03-01

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Effect of Age on the Hemostatic Function in Patients with Degenerative Diseases of the Large Joints  

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Full Text Available Background: Aging is associated with an increased hypercoagulable state. Degenerative diseases of the large joints are also accompanied by increased coagulation activity. We investigated the effect of age on the hemostatic function in patients with osteoarthritis. Material and Methods: The study included 192 patients with osteoarthritis admitted to the clinic for primary hip or knee arthroplasty. The patients were categorized into 5 age groups: the age group under 40 years, the 41–to-50 -year age group, the 51–to-60-year age group, the 61-to-70- year age group, and the age group over 70 years. The general blood clotting tests, platelet number, fibrinogen, antithrombin, protein C, TAT, D-dimer, vonWillebrand factor (vWF, PAI-1, ß-thromboglobulin were determined. Results: Among patients with osteoarthritis, the antithrombin III level significantly decreased by the age of 50; however, above the age of 60 there was a distinct decrease in platelet count, and over the age of 70 the activity of the extrinsic coagulation pathway and the plasminogen level dropped significantly. TAT and D-dimer levels were elevated in most of the patients. Conclusion: The decrease in platelet count coupled with the activity of the extrinsic coagulation pathway in elderly osteoarthritic patients may increase blood loss during total arthroplasty; also, the drop in the anticoagulant and fibrinolytic potential may play a negative role in strengthening the prothrombotic state during the postoperative period.

Igor L. Shlykov, PhD¹, ScD¹

2013-06-01

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Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report  

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A 5-year-old German Warmblood stallion with chronic lameness, attributable to degenerative joint disease (DJD) of the pastern joint unresponsive to medical treatments, was treated with autologous mesenchymal stem cells (MSC). These MSC were isolated from the peripheral blood (PB) of the patient and injected into the pastern joint, at a concentration of 2.5x10(6) cells, twice with an 8-week interval. The positive response to this stem cell treatment was documented by visual gait evaluation as ...

Spaas, Jan; Oosterlinck, Maarten; Broeckx, Sarah; Dumoulin, Miche?le; Saunders, Jimmy; Soom, Ann; Pille, Frederik; Walle, Gerlinde

2012-01-01

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Classifying degenerative joint disease by the RDC/TMD and by panoramic imaging: a retrospective analysis.  

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The purposes of the study were to evaluate the utility of diagnosing degenerative joint disease (DJD) by the clinical finding of coarse crepitus alone, without supporting imaging studies, as defined by the RDC/TMD, and to evaluate the contribution of panoramic radiography as an aid in the diagnosis of DJD. A retrospective analysis of 372 consecutive patients with TMD was conducted. Their panoramic radiographs were evaluated for the extent of their contribution to the final diagnosis. Panoramic radiography was of no diagnostic value in 94.4% of the cases when the group was considered as a whole. When patients diagnosed with DJD were considered separately, panoramic radiography was completely sufficient for reaching the final diagnosis in 20.0% of the cases. In almost 90% of these patients, however, the clinical examination did not support the diagnosis of DJD (no coarse crepitus was found). This raises some doubts about the effectiveness of the clinical examination according to the RDC/TMD and about the utility of panoramic radiography in the definitive diagnosis of DJD, because both techniques have low accuracy (11.1% and 20%, respectively). The present study supports the current recommendations that panoramic radiography should not be ordered routinely to assess DJD, but still it is first choice when any dental problem is suspected. Further additional imaging (computerized tomography, magnetic resonance imaging) should be considered only if there is reason to expect that the findings might affect diagnosis and management. This study adds to recent criticisms of the clinical validity of the RDC/TMD, with regard to DJD. PMID:20002532

Winocur, E; Reiter, S; Krichmer, M; Kaffe, I

2010-03-01

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Gas-filled parasymphyseal pubic cyst associated with degenerative joint disease  

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Parasymphyseal cysts are a rare and poorly understood entity. This case report describes a gas-containing parasymphyseal cystic lesion associated with degenerative change and vacuum phenomenon in the pubic symphysis. The mass was discovered incidentally in a 72-year-old asymptomatic male who underwent a transrectal ultrasound-guided biopsy of the prostate and the nature of the lesion was confirmed on magnetic resonance imaging (MRI) and computed tomography (CT). We hypothesize that the gas within the parasymphyseal cystic mass arose from a vacuum phenomenon in the pubic symphysis, with subsequent extrusion of gas from the joint into the cyst itself. It is important for radiologists to be aware of the existence of this entity to avoid unnecessary surgery for patients. (orig.)

2007-06-01

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Gas-filled parasymphyseal pubic cyst associated with degenerative joint disease  

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Parasymphyseal cysts are a rare and poorly understood entity. This case report describes a gas-containing parasymphyseal cystic lesion associated with degenerative change and vacuum phenomenon in the pubic symphysis. The mass was discovered incidentally in a 72-year-old asymptomatic male who underwent a transrectal ultrasound-guided biopsy of the prostate and the nature of the lesion was confirmed on magnetic resonance imaging (MRI) and computed tomography (CT). We hypothesize that the gas within the parasymphyseal cystic mass arose from a vacuum phenomenon in the pubic symphysis, with subsequent extrusion of gas from the joint into the cyst itself. It is important for radiologists to be aware of the existence of this entity to avoid unnecessary surgery for patients. (orig.)

Martel, J.P.; Spouge, A.R. [London Health Science Centre, Diagnostic Imaging University Hospital, London, ON (Canada)

2007-06-15

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Imaging of degenerative and posttraumatic disease in the shoulder joint with ultrasound  

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This article reviews the examination technique of shoulder ultrasound, normal and abnormal ultrasound findings in acute (posttraumatic) and chronic (degenerative) lesions. Moreover, it reviews the effectiveness of ultrasound in relation to magnetic resonance (MR) imaging. Most authors report that full-thickness tears of the supraspinatus can reliably be diagnosed by ultrasound. However, the simple diagnosis of a full-thickness rotator cuff tear is no longer sufficient for surgical management. The precise localization and size of rotator cuff tears as well as the extent of muscle degeneration is important for surgical planning. For this aspect and for partial-thickness tears of the supraspinatus, for subscapularis lesions as well as for lesions of the long biceps tendons there is no consensus regarding the diagnostic value of ultrasound. To the present, ultrasound (contrary to MR imaging) has failed to demonstrate that it consistently influences the clinician's degree of confidence in the clinical diagnosis or the treatment plan. Therefore, some orthopedic surgeons prefer MR imaging to ultrasound in the evaluation of rotator cuff tears and other abnormalities of the glenohumeral joint. Moreover, MR imaging, especially when combined with arthrography, represents a one-step investigation, which not only allows for assessment of rotator cuff lesion but also of lesions of the labrum (Bankart lesions, SLAP lesions), the joint capsule and the biceps tendon. It also demonstrates muscle atrophy, which represents an important predictor of surgical outcome in rotator cuff repair

2000-08-01

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Imaging of degenerative and posttraumatic disease in the shoulder joint with ultrasound  

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This article reviews the examination technique of shoulder ultrasound, normal and abnormal ultrasound findings in acute (posttraumatic) and chronic (degenerative) lesions. Moreover, it reviews the effectiveness of ultrasound in relation to magnetic resonance (MR) imaging. Most authors report that full-thickness tears of the supraspinatus can reliably be diagnosed by ultrasound. However, the simple diagnosis of a full-thickness rotator cuff tear is no longer sufficient for surgical management. The precise localization and size of rotator cuff tears as well as the extent of muscle degeneration is important for surgical planning. For this aspect and for partial-thickness tears of the supraspinatus, for subscapularis lesions as well as for lesions of the long biceps tendons there is no consensus regarding the diagnostic value of ultrasound. To the present, ultrasound (contrary to MR imaging) has failed to demonstrate that it consistently influences the clinician's degree of confidence in the clinical diagnosis or the treatment plan. Therefore, some orthopedic surgeons prefer MR imaging to ultrasound in the evaluation of rotator cuff tears and other abnormalities of the glenohumeral joint. Moreover, MR imaging, especially when combined with arthrography, represents a one-step investigation, which not only allows for assessment of rotator cuff lesion but also of lesions of the labrum (Bankart lesions, SLAP lesions), the joint capsule and the biceps tendon. It also demonstrates muscle atrophy, which represents an important predictor of surgical outcome in rotator cuff repair.

Zanetti, Marco E-mail: mzanetti@balgrist.unizh.ch; Hodler, Juerg

2000-08-01

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Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series.  

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Regenerative therapeutic strategies for joint diseases usually employ either enriched concentrates of bone marrow-derived stem cells, chondrogenic preparations such as platelet-rich plasma, or irritant solutions such as hyperosmotic dextrose. In this case series, we describe our experience with a simple, cost-effective regenerative treatment using direct injection of unfractionated whole bone marrow (WBM) into osteoarthritic joints in combination with hyperosmotic dextrose. Seven patients with hip, knee or ankle osteoarthritis (OA) received two to seven treatments over a period of two to twelve months. Patient-reported assessments were collected in interviews and by questionnaire. All patients reported improvements with respect to pain, as well as gains in functionality and quality of life. Three patients, including two whose progress under other therapy had plateaued or reversed, achieved complete or near-complete symptomatic relief, and two additional patients achieved resumption of vigorous exercise. These preliminary findings suggest that OA treatment with WBM injection merits further investigation. PMID:24046512

Hauser, Ross A; Orlofsky, Amos

2013-01-01

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Oral treatment options for degenerative joint disease--presence and future.  

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Alleviation of pain and inhibition of inflammation are the primary goals of pharmacotherapy of osteoarthritis (OA). These therapeutic goals can almost always be accomplished by the use of analgesics and nonsteroidal anti-inflammatory drugs (NSAID). One of the main problems of NSAIDs is their gastrointestinal toxicity, for which a prophylactic medication should be considered particularly amongst risk groups. Recent studies have shown that COX-2-selective and maybe also non-selective NSAIDs increase the cardiovascular risk so that their application is getting now drastically restricted. Pharmacological results published until now suggest that a clinically relevant minor analgesic and/or anti-inflammatory effect can be attained with the use of some of the SYmptomatic Slow Acting Drugs in OA (SYSADOAs). However, no clinical studies exist, which can positively confirm prevention, slowing down or reversal of any advanced joint cartilage destruction by any individual medication. Disease modifying therapy is still in its infancy; discovery and development of novel therapeutic targets and agents are an extremely difficult task, currently challenging many pharmaceutical companies and academic institutions. PMID:16616797

Steinmeyer, Jürgen; Konttinen, Yrjö T

2006-05-20

 
 
 
 
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Some Peculiarities of Bone Tissue Remodelling at Hip Joint Inflammatory and Degenerative Diseases  

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During the assessment of peculiarities of bone tissue remodelling in inflammatory and non inflammatory lesions of hip joint, according to the levels of biochemical indices in the blood serum, some unilateral changes of bone tissue metabolism have been revealed in advanced rheumatoid arthritis and osteoarthrosis. More severe disturbances of bone remodelling in case of rheumatoid arthritis are obviously connected with peculiarities of the rheumatoid inflammation pathogenesis.

Karyakina, E. V.; Persova, E. A.

2009-01-01

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Some Peculiarities of Bone Tissue Remodelling at Hip Joint Inflammatory and Degenerative Diseases  

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Full Text Available During the assessment of peculiarities of bone tissue remodelling in inflammatory and non inflammatory lesions of hip joint, according to the levels of biochemical indices in the blood serum, some unilateral changes of bone tissue metabolism have been revealed in advanced rheumatoid arthritis and osteoarthrosis. More severe disturbances of bone remodelling in case of rheumatoid arthritis are obviously connected with peculiarities of the rheumatoid inflammation pathogenesis.

E.A. Persova

2009-06-01

23

Low back pain and degenerative disc disease  

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Full Text Available Introduction. Various clinical conditions can cause low back pain, and in most cases it is of a degenerative origin. Degenerative disc disease is a common condition which affects young to middle-aged men and women equally. Changes in the mechanical properties of the disc lead to degenerative arthritis in the intervertebral joints, osteophytes, and narrowing the intervertebral foramen or the spinal canal. Pathophysiology. Degenerative cascade, described by Kirkaldy-Willis, is the widely accepted pathophysiologic model describing the degenerative process as it affects the lumbar spine in 3 phases. Diagnosis. There are two forms of low back pain secondary to degenerative disc disease: a lumbalgia and b lumbar radiculopathy. Limitation of movement, problems with balance, pain, loss of reflexes in the extremities, muscle weakness, loss of sensation or other signs of neurological damage can be found on physical examination. For accurate diagnosis, it is often necessary to combine clinical examination and sophisticated technology. Treatment. Coservative treatment consists of rest, physical therapy, pharmacological therapy and injection therapy. Physical rehabilitation with active patient participation is a key approach to treatment of patients with discogenic pain. Physical therapy, occupational therapy and kinesitherapy are important for improving muscle strength, endurance, and flexibility. Disc surgery is performed if surgical intervention is required. .

Jandri? Slavica

2006-01-01

24

A radiologic and histologic study of the os peroneum: prevalence, morphology, and relationship to degenerative joint disease of the foot and ankle in a cadaveric sample.  

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The present study investigated the prevalence of an os peroneum (OP, a sesamoid bone) in a cadaveric sample and its relationship to the shape of the cuboid tuberosity, and cartilage degeneration at the cuboid tuberosity and in regional joints within the foot (first metatarsophalangeal and calcaneocuboid) and ankle. The fibularis longus tendon of 33 embalmed human cadavers (mean age 81 years) were obtained from the anatomy laboratory. Nineteen of 64 tendons (30%) displayed an OP both radiographically and histologically. The os peronei ranged in size from small spicules to prominent masses: mean area 2.48 mm(2) (left) and 2.70 mm(2) (right). Histologically, the os peronei were cancellous bone, the largest occupying most of the tendon at the point of contact with the cuboid tuberosity. Fibrocartilage was present at their borders, merging with dense regular fibrous tissue and peritenon. The talocrural, calcaneocuboid, and first metatarsophalangeal joints were examined for cartilage integrity and osteophytes based on an earlier suggestion that there may be an association between degenerative joint disease and endochondral bone formation. There was no statistical correlation between presence of an OP with any of the following parameters: age, gender, body size, cartilage degeneration, or osteophytes within any of the joints examined. Therefore, the presence of an OP does not appear to be associated with increased endochondral ossification or degenerative joint disease. This study does not preclude the possibility that sesamoid bone formation may be associated with biomechanical functions within the foot; thus, future studies may be warranted. PMID:19637293

Muehleman, C; Williams, J; Bareither, M L

2009-09-01

25

A radiological study on the degenerative joint disease of the lumbar spine in Korean adult men below the age of forty  

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It is generally believed that this disease is a degenerative process, a part of the general phenomena, hastened by excessive functional demand and a decreasing efficiency of blood supply. Though degenerative joint disease is the commonest of all ailments, its manifestations do not appear as a rule until the fourth or fifth decade, and it is not always easy to diagnose because we know less about it than about many less common types. Little information is available on its frequency in person below the age of forty. The present study was designed to obtain more precise information about development of this disease in person below the age of forty. After a detailed clinical examination, x-ray findings of a total of 566 men with low back pain checked at the Department of Radiology, National Public Hospital from Jan. 1976 to Dec. 1978 were received. The following result were obtained: 1. 111 (19.6%) of the 566 men had radiologic evidence of degenerative disease in lumbar spine. The degenerative joint disease first appeared on the age of 26. The degenerative joint disease was found in 16 (14.9%) of the 107 men between 25 and 29 years old, 14 (16.3%) of the 86 men between 35 and 39 years old, 31 (27.4%) of the 113 men between 35 and 39 years old, and 50 (50%) of the 100 between 40 and 44 years old. 2.The 4th lumbar spine was most commonly involved, being in 82.0% of the cases, and less frequent sites were the 5th lumbar spine (67.6%), the 3rd lumbar spine (51.3%), the 2nd lumbar spine (18.9%) and the 1st lumbar spine (3.6%). 38 (28.8%) of the 111 cases revealed single level involvement, but 79 (71.2%) cases showed multiple level involvement with the highest incidence at 14 and 15. 3. 111 cases of the 566 revealed marginal spurring. Bridging was noted in 8 cases, space narrowing 8 cases, and eburnation 7 caes.

1979-06-01

26

Genetic and somatic radiation doses in radiotherapy of inflammatory and degenerative diseases of bones, joints and soft parts  

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Dose measurements were performed in several body regions of patients suffering from inflammatory degenerative diseases (humeral epicondylitis, humeroscapular periarthritis, gonarthrosis, axillary hidradenitis, rheumatoid arthritis, coxarthrosis, parotitis). The problem of the radiation induction of neoplasms is predominant concerning somatic as well as genetic risk, discussed by example of the most frequently occurring organ cancer. Compared to the rate of breast cancer in the highly developed industrial states (5,000 to 6,000 cancers/100,000 women) the 'radiation induction' calculated according to a mathematical model of ICRP 26 (1.25 cases of death for breast cancers/100,000 women following for example irradiation of epicondylitis) is behind several powers of ten and not demonstrable. The genetic radiation exposure is also low. Derived from the measurements it is wrong to give up reliable and approved indications of radiotherapy of non-malignant diseases because of unfounded radiophobia.

Kirsch, M.; Keinert, K.; Schumann, E. (Medizinische Akademie, Erfurt (German Democratic Republic). Radiologische Klinik)

1983-01-01

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On the genetic and somatic radiation doses in radiotherapy of inflammatory and degenerative diseases of bones, joints and soft parts  

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Dose measurements were performed in several body regions of patients suffering from inflammatory degenerative diseases (humeral epicondylitis, humeroscapular periarthritis, gonarthrosis, axillary hidradenitis, rheumatoid arthritis, coxarthrosis, parotitis). The problem of the radiation induction of neoplasms is predominant concerning somatic as well as genetic risk, discussed by example of the most frequently occurring organ cancer. Compared to the rate of breast cancer in the highly developed industrial states (5,000 to 6,000 cancers/100,000 women) the 'radiation induction' calculated according to a mathematical model of ICRP 26 (1.25 cases of death for breast cancers/100,000 women following for example irradiation of epicondylitis) is behind several powers of ten and not demonstrable. The genetic radiation exposure is also low. Derived from the measurements it is wrong to give up reliable and approved indications of radiotherapy of non-malignant diseases because of unfounded radiophobia. (author)

1983-01-01

28

Epigenetics mechanisms and degenerative diseases  

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Full Text Available Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms include histone modifications and DNA methylations. In this review, we examine methods to study DNA methylations and their contribution to degenerative diseases by mediating the complex gene-by-environment interactions. Such epigenetic modifications despite being heritable and stably maintained are also potentially reversible and there is scope for the development of epigenetic therapies for this disease.

 

2012-12-01

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Correction of collapsed occlusion with degenerative joint disease focused on the mandibular arch and timely relocation of a miniplate.  

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This report describes a novel concept of 3-dimensional tooth movement by using biocreative therapy to provide unrestricted distal movement of the full mandibular dentition. The patient was a 26-year-old Korean woman with multiple problems, including a collapsed occlusion, a full-step Class III relationship with posterior open bite, a crossbite, temporomandibular joint pain, and a tendency for root resorption. Two orthodontic miniplates with tubes were initially placed on both retromolar pads for distalization; 1 miniplate was relocated to the anterior region for angulation and vertical control of the anterior teeth. The total treatment period was 13 months. The occlusion was finished in Class I molar and canine relationships with optimal overjet and overbite. Posttreatment records 2.5 years later showed a stable treatment outcome. The results suggest that an orthodontic miniplate is an efficient tool for the treatment of a collapsed occlusion by changing the affected arch only. PMID:22381502

Chung, Kyu-Rhim; Ahn, Hyo-Won; Kim, Su-Jung; Lee, Kye-Bok; Kim, Seong-Hun

2012-03-01

30

The sternoclavicular joint: can imaging differentiate infection from degenerative change?  

International Nuclear Information System (INIS)

The purpose of this study was to determine if there are imaging and clinical findings that can differentiate a septic sternoclavicular joint from a degenerative one. Search of radiology reports from 2000-2007 revealed 460 subjects with imaging of the sternoclavicular joint, of whom 38 had undergone aspiration or biopsy. The final study group consisted of nine subjects with pathologic proof of sternoclavicular joint infection and ten subjects with pathologic and clinical findings excluding infection consistent with degenerative change. Available ultrasound, computed tomography (CT), and magnetic resonance (MR) images were retrospectively reviewed, and echogenicity, capsular distention, erosions, cysts, hyperemia or enhancement, and intensity of bone marrow signal were recorded. Clinical data were also reviewed. The findings significantly associated with sternoclavicular joint infection included degree and extent of capsular distention. With infection, average joint distention was 14 mm (range 10-20 mm) and extended over the sternum and clavicle in 60% compared to 5 mm (range 3-8 mm) with degeneration only extending over the clavicle. Other findings significantly associated with infection included bone marrow fluid signal on magnetic resonance imaging (MRI), elevated Westergren red blood cell sedimentation rate, and fever. The two findings significantly associated with degeneration were subchondral cysts on CT and female gender. Other imaging and clinical variables showed no significant differences between infection and degenerative change. The clinical and imaging findings significantly associated with sternoclavicular joint infection included joint capsule distention of 10 mm or greater, extension over both the clavicle and sternum, adjacent fluid signal bone marrow replacement, elevated Westergren red blood cell sedimentation rate, and fever. (orig.)

2010-06-01

31

Imaging and translational research: neuro degenerative diseases  

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Advances in neuroimaging of neuro-degenerative diseases over the past two decades are the product of breakthroughs in imaging technology, more powerful computers, image-processing software, and expanding knowledge in basic and clinical neuro-science. In addition to the insights into normal brain structure and function that such methods provide, and the information that can be gained from disease-related changes in structure and function, functional imaging offers the promise of monitoring brain lesions and quantifying the therapeutic efficacy of innovative treatments for these largely incurable disorders. (author)

Hantraye, P. [CEA Fontenay-aux-Roses, MIRC, 92 (France)

2009-07-01

32

Imaging and translational research: neuro degenerative diseases  

International Nuclear Information System (INIS)

Advances in neuroimaging of neuro-degenerative diseases over the past two decades are the product of breakthroughs in imaging technology, more powerful computers, image-processing software, and expanding knowledge in basic and clinical neuro-science. In addition to the insights into normal brain structure and function that such methods provide, and the information that can be gained from disease-related changes in structure and function, functional imaging offers the promise of monitoring brain lesions and quantifying the therapeutic efficacy of innovative treatments for these largely incurable disorders. (author)

2009-01-01

33

Computed tomography in lumbar degenerative disease  

International Nuclear Information System (INIS)

We reported the 18 patients which underwent surgical exploration and reviewed these CT findings. Method All CT scans were obtained on Somatom II, high resolution CT scanner, with the patient in the supine position. A lateral localizer image (Topogram) was used to select the appropriate intervertebral disk space. The slice thickness was 4 mm. Results 1) CT findings in lumbar degenerative diseases include bony canal stenosis (central canal stenosis, narrowed lateral recess), soft tissue abnormalities (herniated nucleus pulposus, bulging annulus, hypertrophy and/or ossification of ligamentum flavum, no delineation of nerve root in lateral recess), and spinal instability (spondylolisthesis, vacuum phenomenon). 2) The above three factors contribute to narrowing of spinal canal. 3) No delineation of nerve root or soft tissue replacement of epidural fat in lateral recess suggests that the nerve root may be compressed by some factors. 4) Herniated nucleus pulposus may cause nerve root compression with or without canal stenosis. Conclusion This study revealed that the CT findings correlated closely with the surgical findings and the site of nerve root compression could be determined. (author)

1984-01-01

34

Computed tomography in lumbar degenerative disease  

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We reported the 18 patients which underwent surgical exploration and reviewed these CT findings. Method All CT scans were obtained on Somatom II, high resolution CT scanner, with the patient in the supine position. A lateral localizer image (Topogram) was used to select the appropriate intervertebral disk space. The slice thickness was 4 mm. Results 1) CT findings in lumbar degenerative diseases include bony canal stenosis (central canal stenosis, narrowed lateral recess), soft tissue abnormalities (herniated nucleus pulposus, bulging annulus, hypertrophy and/or ossification of ligamentum flavum, no delineation of nerve root in lateral recess), and spinal instability (spondylolisthesis, vacuum phenomenon). 2) The above three factors contribute to narrowing of spinal canal. 3) No delineation of nerve root or soft tissue replacement of epidural fat in lateral recess suggests that the nerve root may be compressed by some factors. 4) Herniated nucleus pulposus may cause nerve root compression with or without canal stenosis. Conclusion This study revealed that the CT findings correlated closely with the surgical findings and the site of nerve root compression could be determined.

Isu, Toyohiko; Miyasaka, Kazuo; Abe, Satoru; Takei, Hidetoshi; Kaneda, Kiyoshi (Hokkaido Univ., Sapporo (Japan). School of Medicine)

1984-02-01

35

Imaging of lumbar degenerative disk disease: history and current state  

International Nuclear Information System (INIS)

One of the most common indications for performing magnetic resonance (MR) imaging of the lumbar spine is the symptom complex thought to originate as a result of degenerative disk disease. MR imaging, which has emerged as perhaps the modality of choice for imaging degenerative disk disease, can readily demonstrate disk pathology, degenerative endplate changes, facet and ligamentous hypertrophic changes, and the sequelae of instability. Its role in terms of predicting natural history of low back pain, identifying causality, or offering prognostic information is unclear. As available modalities for imaging the spine have progressed from radiography, myelography, and computed tomography to MR imaging, there have also been advances in spine surgery for degenerative disk disease. These advances are described in a temporal context for historical purposes with a focus on MR imaging's history and current state. (orig.)

2011-09-01

36

Effects of chondroitin sulfate and sodium hyaluronate on chondrocytes and extracellular matrix of articular cartilage in dogs with degenerative joint disease Efeitos do sulfato de condroitina e do hialuronato de sódio nos condrócitos e na matriz extracelular na cartilagem articular de cães com doença articular degenerativa  

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Samples of articular cartilage of femur, tibia and patella of 15 dogs with experimentally induced degenerative joint disease (DJD) were microscopically analyzed. Animals were distributed into three groups (n=5): the control group received no medication; the second group was treated with chondroitin sulfate and the third received sodium hyaluronate. Samples were processed and stained with HE and toluidine blue for morphological evaluation. The metabolic and proliferative activity of the chondr...

2008-01-01

37

Radiologic manifestations of degenerative-dystrophic lesion of false joints of the limbs  

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There have been examined 752 patients with false joints and defects of articular ends of the long tubular bones. Various forms of degenerative-dystrophic lesion of the false joints and neoarthrosis which developed after resection of the articular end, as well as of other sections of bones and joints preconditioned by the long-term overload, have been studied in that group. Degenerative-dystrophic damage has been established to be one of the main causes of secondary sub-and decompensation that manifests by cystic transformation, aseptic necrosis and, in extremely rare cases, deforming arthrosis of the former lesion area. Similar alterations in the adjacent and distant overloaded sections of bones and joints are also thought to belong to causative factors. The importance of the timely multiple X-ray examination has been shown, particularly in detecting early manifestations of degenerative-dystrophic lesion in clinical and preclinical phases

1980-01-01

38

Prevalence of degenerative joint complaints of the lower extremity: a representative study  

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As part of the international campaign of the bone and joint decade, we aimed to present epidemiological data on the prevalence of major joint complaints in a Central European region. Ten thousand subjects aged between 14 and 65, selected randomly by the Hungarian central office of statistics from three counties in southern Hungary, were surveyed using our own questionnaire based on widely accepted scoring systems in the literature, focusing on major degenerative joint complaints, and using th...

Horva?th, G.; Than, P.; Bellyei, A?; Kra?nicz, J.; Ille?s, T.

2006-01-01

39

Imaging fusion (SPECT/CT) in degenerative disease of spine  

International Nuclear Information System (INIS)

Full text: Objective: To determine the utility of Fusion Imaging SPECT/CT in degenerative pathology of the spine and to establish the impact of the use of fusion imaging in spinal pain due to degenerative changes of the spine. Materials and methods: 44 Patients (M=21, F=23) average age of 63 years and with degenerative pathology of spine were sent to Diagnosis Imaging department in FSFB. Bone scintigraphy (SPECT), CT of spine (cervical: 30%, Lumbar 70%) and fusion imaging were performed in all of them. Bone scintigraphy was carried out in a gamma camera Siemens Diacam double head attached to ESOFT computer. The images were acquired in matrix 128 x 128, 20 seg/imag, 64 images. CT of spine was performed same day or two days after in Helycoidal Siemens somatom emotion CT. The fusion was done in a Dicom workstation in sagital, axial and coronal reconstruction. The findings were evaluated by 2 Nuclear Medicine physicians and 2 radiologists of the staff of FSFB in an independent way. Results: Bone scan (SPECT) and CT of 44 patients were evaluated. CT showed facet joint osteoarthrities in 27 (61.3%) patients, uncovertebral joint arthrosis in 7 (15.9%), bulging disc in 9(20.4%), spinal nucleus lesion in 7(15.9%), osteophytes in 9 (20.4%), spinal foraminal stenosis in 7 (15.9%), spondylolysis/spondylolisthesis in 4 (9%). Bone scan showed facet joint osteoarthrities in 29 (65.9%), uncovertebral joint arthrosis in 4 (9%), osteophytes in 9 (20.4%) and normal 3 (6.8%). The imaging fusion showed coincidence findings (main lesion in CT with high uptake in scintigraphy) in 34 patients (77.2%) and no coincidence in 10 (22.8%). In 15 (34.09%) patients the fusion provided additional information. The analysis of the findings of CT and SPECT showed similar results in most of the cases and the fusion didn't provide additional information but it allowed to confirm the findings but when the findings didn't match where the CT showed several findings and SPECT only one area with high uptake which allowed us to address the treatment. In all cases, CT provided exact anatomical localization. Conclusion; Fusion imaging SPECT/CT in degenerative pathology of spine allows an integration of the anatomical detail with the functional information. It improves the diagnostic accuracy: Determining sites of greater metabolic activity in patients with multiple degenerative changes and improving the spatial localization in injuries detected by scintigraphy. Image fusion by SPECT/CT could have a clinical impact (34% of our series) in that the treatment was modified. (author)

2007-07-01

40

ENFERMEDAD ARTICULAR DEGENERATIVA Y CAMBIOS ENTESIALES EN SEIS COLECCIONES ÓSEAS PREHISPÁNICAS DEL NOROCCIDENTE DE AMÉRICA DEL SUR / DEGENERATIVE JOINT DISEASE AND ENTHESEAL CHANGES IN SIX PRE-COLUMBIAN SKELETAL COLLECTIONS FROM THE NORTHWEST OF SOUTH AMERICA  

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Full Text Available SciELO Chile | Language: Spanish Abstract in spanish La enfermedad articular degenerativa (EAD) y los cambios entesiales (CE) fueron estudiados en seis colecciones óseas prehispánicas del noroeste de América del Sur con el objetivo de aportar al debate sobre las relaciones entre estos indicadores y la actividad física, así como al conocimiento sobre l [...] as condiciones de vida de los pueblos prehispánicos de la región. Se estudiaron tres series del altiplano central de Colombia (Soacha, Marín y Tunja-UPTC), dos series de Panamá (Panamá Viejo y Sitio Sierra) y una colección de la costa central peruana (Ancón 1). El uso de una metodología estandarizada permitió la comparación directa de frecuencias y perfiles de EAD y de CE. Se observó una importante variedad de perfiles y de frecuencias en las diferentes colecciones óseas, pero también algunas tendencias similares en colecciones de ambientes semejantes. Se observó una falta de correspondencia entre los resultados de la EAD y de los CE que podría indicar que, a pesar de que tienen una etiología multifactorial, podrían ser respuestas a diferentes tipos de actividad: una actividad repetitiva podría relacionarse más con la EAD, mientras que una actividad que incluya cargas pesadas podría relacionarse más con los CE. Abstract in english Degenerative joint disease (DJD) and entheseal changes (EC) were studied in six Pre-Hispanic skeletal collections from the northwest of South America, in order to give insight both into their relationship with physical activity and into life conditions in this region during Pre-Columbian times. Thre [...] e series from the highlands of Colombia (Soacha, Marín and Tunja-UPTC), two series from Panama (Panamá Viejo and Sitio Sierra) and one from the Central Coast of Peru (Ancón 1) were analyzed for this study. The use of a standardized methodology allowed direct comparisons between the frequencies and the profiles of DJD and EC. An important variability in profiles and frequencies was observed between series. However, it was also possible to observe several similar trends in series from analogous environments. There is a mismatch between results from DJD and EC which may indicate that, despite having a multi-factorial aetiology, they may respond to different types of physical activity: repetitive activity would be more related to DJD, while activities involving heavy loads would be more connected with EC.

Rojas-Sepúlveda, Claudia Mercedes; Dutour, Olivier.

 
 
 
 
41

Radiotherapy of degenerative joint disorders. Indication, technique and clinical results  

International Nuclear Information System (INIS)

From 1984 to 1994, 85 patients with painful osteoarthritis were treated. The mean follow-up was 4 (1 to 10) years. Seventy-three patients (103 joints) were available for long-term analysis: 17 patients (27 joints) with omarthrosis, 19 (20 joints) with rhizarthrosis, 31 (49 joints) with osteoarthritis of the knee and 6 patients (7 joints) with osteoarthritis of the hip. All patients were intensively pretreated over long time. Mean symptom duration prior to radiotherapy was 4 (1 to 10) years. Orthovoltage or linac photons were applied using some technical modifications depending upon the joint. Two radiotherapy series (6 x 1 Gy, total dose: 12 Gy, 3 weekly fractions) were prescribed. The interval between the 2 series was 6 weeks. The subjective pain profil was assessed prior to and 6 months after radiotherapy and at last follow-up. Forty-six (63%) patients (64 joints) achieved a reduction of pain symptoms; 16 of those had a 'major pain relief' and 14 'complete pain relief'. Large joints - knee and hip - responded better (64% each) than the rhizarthrosis (53%). All pain categories and grades and their combined pain score were significantly reduced. The pain reduction was mostly pronounced for the symptom 'pain at rest'. The orthopedic score correlated well with the subjective response of the patients. The thumb score improved in 11 (57%) joints, the shoulder score of Constant and Murley in 16 (59%), the Japonese knee score of Sasaki et al. in 33 (67%), the hip score of Harris in 5 (71%) joints. Only 9 of 19 patients which were treated to avoid surgery, had to be operated, and 3 of those received a total arthroplasty of the hip or knee. In multivariate analysis for the endpoint 'complete' or 'major pain relief' only the criterion 'symptom duration ?2 years prior to radiotherapy' was an independent negative prognostic parameter. (orig./MG)

1998-05-01

42

Promises of stem cell therapy for retinal degenerative diseases  

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With the development of stem cell technology, stem cell-based therapy for retinal degeneration has been proposed to restore the visual function. Many animal studies and some clinical trials have shown encouraging results of stem cell-based therapy in retinal degenerative diseases. While stem cell-based therapy is a promising strategy to replace damaged retinal cells and ultimately cure retinal degeneration, there are several important challenges which need to be overcome before stem cell tech...

2011-01-01

43

Sporadic Inclusion Body Myositis: Inflammatory and Degenerative Disease Mechanisms  

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Sporadic inclusion body myositis (sIBM) is an enigmatic disease resistant to immunomodulatory treatment and featuring autoimmune and degenerative aspects: clonally expanded CD8+ T cells focally infiltrate uniformly HLA-I+ myofibers that harbor beta-amyloid deposits. In a non-hypothesis-driven approach, CD8+ T cell-attacked and non-attacked myofibers were compared on the transcriptional level. To this end, cytosol of such attacked and non-attacked myofibers was isolated independently using las...

Ivanidze, Jana

2011-01-01

44

Sulfato de condroitina e hialuronato de sódio no tratamento da doença articular degenerativa experimental em cães: aspectos clínicos e radiológicos Chondroitin sulfate and sodium hialuronate in treatment of the degenerative joint disease in dogs: clinical and radiological aspects  

Directory of Open Access Journals (Sweden)

Full Text Available Avaliaram-se clínica e radiograficamente os efeitos do sulfato de condroitina e do hialuronato de sódio no tratamento da articulação femorotibiopatelar de cães com doença articular degenerativa (DAD induzida experimentalmente. Foram utilizados 15 cães, sem raça definida, de ambos os sexos, pesando entre 18 e 25 kg, submetidos à secção artroscópica do ligamento cruzado cranial (LCCr para desestabilização articular e indução da DAD. Após três semanas de instabilidade articular, o LCCr foi substituído utilizando-se a técnica intra-articular com emprego da fáscia lata. Os animais foram divididos em três grupos de cinco. Nos do grupo I fez-se somente a substituição do LCCr. Os do grupo II receberam 24mg/animal de sulfato de condroitina, via IM, de cinco em cinco dias, totalizando seis aplicações. Os do grupo III foram tratados com hialuronato de sódio na dose de 20mg/animal, via IV, de cinco em cinco dias, num total de três aplicações. Os animais foram observados por 90 dias, e avaliados clinicamente quanto à claudicação, à capacidade de suportar peso no membro afetado, à mensuração da atrofia muscular e à amplitude de movimento articular. Ao final, foram encaminhados para novo exame radiográfico. Os resultados demonstraram que os animais que receberam hialuronato de sódio apresentaram menor grau de claudicação quando comparados com os demais. Ao exame radiográfico observaram-se osteofitose periarticular e esclerose óssea subcondral. Essas alterações foram evidenciadas de forma mais acentuada nos animais tratados com hialuronato de sódio. Clinicamente, pôde-se observar melhor resultado com o hialuronato de sódio do que nos demais grupos, possivelmente devido à sua maior ação na membrana sinovial, reduzindo a dor e o grau de claudicação. O exame radiográfico não foi compatível com a sintomatologia clínica nos cães tratados com hialuronato de sódio.The aim of this study was the evaluation of the effects of chondroitin sulfate and sodium hyaluronate in the knee joint of dogs with experimentally induced degenerative joint disease (DJD. Fifteen mongrel dogs, weighing 18 to 25kg were used. DJD was induced by cranial cruciate ligament (CCL arthroscopical transection. After three weeks, CCL was repaired by an intrarticular technique, which uses fascia lata. The dogs were then divided into three groups as follows: group I received no other treatment, but the CCL reconstitution, group II received 24mg/animal of chondroitin sulfate/IM every five days, totaling six injections, and group III received 20mg/animal of sodium hyaluronate /IV every five days, totaling three injections. All dogs were examined clinically and radiographically for 90 days after the repairment surgery. The clinical evaluation was performed by assessment of lameness, weight-bearing, limb muscle atrophy and range of motion. The results demonstrated that the group treated with sodium hyaluronate had lower degree of lameness in comparison with other groups. The radiographic evaluation showed marginal osteophytes and subchondral bone sclerosis. These changes were more severe in the group treated with sodium hyaluronate. The better clinical results observed in this group, compared with the others, was probably due to the greater action of the drug in the synovium, decreasing the pain and lameness. Radiographic findings correlated poorly with the clinical signs in the group treated with sodium hyaluronate.

E.G. Melo

2003-02-01

45

Sulfato de condroitina e hialuronato de sódio no tratamento da doença articular degenerativa experimental em cães: aspectos clínicos e radiológicos / Chondroitin sulfate and sodium hialuronate in treatment of the degenerative joint disease in dogs: clinical and radiological aspects  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Avaliaram-se clínica e radiograficamente os efeitos do sulfato de condroitina e do hialuronato de sódio no tratamento da articulação femorotibiopatelar de cães com doença articular degenerativa (DAD) induzida experimentalmente. Foram utilizados 15 cães, sem raça definida, de ambos os sexos, pesando [...] entre 18 e 25 kg, submetidos à secção artroscópica do ligamento cruzado cranial (LCCr) para desestabilização articular e indução da DAD. Após três semanas de instabilidade articular, o LCCr foi substituído utilizando-se a técnica intra-articular com emprego da fáscia lata. Os animais foram divididos em três grupos de cinco. Nos do grupo I fez-se somente a substituição do LCCr. Os do grupo II receberam 24mg/animal de sulfato de condroitina, via IM, de cinco em cinco dias, totalizando seis aplicações. Os do grupo III foram tratados com hialuronato de sódio na dose de 20mg/animal, via IV, de cinco em cinco dias, num total de três aplicações. Os animais foram observados por 90 dias, e avaliados clinicamente quanto à claudicação, à capacidade de suportar peso no membro afetado, à mensuração da atrofia muscular e à amplitude de movimento articular. Ao final, foram encaminhados para novo exame radiográfico. Os resultados demonstraram que os animais que receberam hialuronato de sódio apresentaram menor grau de claudicação quando comparados com os demais. Ao exame radiográfico observaram-se osteofitose periarticular e esclerose óssea subcondral. Essas alterações foram evidenciadas de forma mais acentuada nos animais tratados com hialuronato de sódio. Clinicamente, pôde-se observar melhor resultado com o hialuronato de sódio do que nos demais grupos, possivelmente devido à sua maior ação na membrana sinovial, reduzindo a dor e o grau de claudicação. O exame radiográfico não foi compatível com a sintomatologia clínica nos cães tratados com hialuronato de sódio. Abstract in english The aim of this study was the evaluation of the effects of chondroitin sulfate and sodium hyaluronate in the knee joint of dogs with experimentally induced degenerative joint disease (DJD). Fifteen mongrel dogs, weighing 18 to 25kg were used. DJD was induced by cranial cruciate ligament (CCL) arthro [...] scopical transection. After three weeks, CCL was repaired by an intrarticular technique, which uses fascia lata. The dogs were then divided into three groups as follows: group I received no other treatment, but the CCL reconstitution, group II received 24mg/animal of chondroitin sulfate/IM every five days, totaling six injections, and group III received 20mg/animal of sodium hyaluronate /IV every five days, totaling three injections. All dogs were examined clinically and radiographically for 90 days after the repairment surgery. The clinical evaluation was performed by assessment of lameness, weight-bearing, limb muscle atrophy and range of motion. The results demonstrated that the group treated with sodium hyaluronate had lower degree of lameness in comparison with other groups. The radiographic evaluation showed marginal osteophytes and subchondral bone sclerosis. These changes were more severe in the group treated with sodium hyaluronate. The better clinical results observed in this group, compared with the others, was probably due to the greater action of the drug in the synovium, decreasing the pain and lameness. Radiographic findings correlated poorly with the clinical signs in the group treated with sodium hyaluronate.

E.G., Melo; C.M.F., Rezende; M.G., Gomes; P.M., Freitas; S.A., Arias S..

46

Diseases of the joints  

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Radiographs are used in diseases of the joints to confirm the clinical diagnosis of joint disease, determine the type of joint disease, and evaluate the extent of clinically known disease. The radiographic findings may be either consistent or inconsistent with the clinical diagnosis. If inconsistent, an alternative diagnosis should be made on the basis of the radiographic appearance of the disease process. On other occasions, joint disease is observed on a radiograph obtained for some other reason, such as for peripheral trauma; on a chest radiograph demonstrating changes in the spine or pectoral girdle; or on radiographs of the abdomen and pelvis revealing abnormalities of the spine, sacroiliac joints, or hips. In the latter situations, the joint disease should be categorized and included in the radiographic report. There are four principal radiographic signs of joint abnormalities or joint disease. These are (1) abnormalities of the apposing margins of both bones at a joint, (2) change in the width of the joint space, usually narrowing, but occasionally, widening due to an increase in synovial fluid, (3) malalignment of the joint (subluxation or dislocation with the joint margins no longer in apposition), and (4) periarticular swelling due to distension of the joint capsule. The most common findings are narrowing of the joint space and abnormalities of the apposing articular margins of bone

1987-01-01

47

Comparación de los efectos de dos técnicas de electroanalgesia en la enfermedad articular degenerativa tarsometatarsiana del equino Comparison between the effects of two electroanalgesical technics in the tarsometatarsal degenerative joint disease  

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Full Text Available Se realizó una experiencia para comparar los resultados analgésicos entre TENS (cuyas siglas derivan de la expresión en inglés: transcutaneus electrical neuromuscular stimulation y el EMAR (estimulación mecánica por acción refleja de efectividad comprobada en medicina equina, sobre un modelo clínico de 10 equinos afectados por enfermedad articular degenerativa tarsometatarsiana con un protocolo diagnóstico estandarizado. Sobre la misma población se hicieron los dos tratamientos con intervalos de 6 meses entre uno y otro comparándose luego los resultados. Las aplicaciones en cada tratamiento fueron diarias y el control clínico se realizó post-tratamientos cada dos días (5 controles totales por los mismos tres profesionales para mantener el mismo esquema de evaluación, considerándose como parámetros: a- Trote en línea recta y en círculo, terreno blando y duro b­Flexión forzada c- Test del tarso (test de Churchill. Se realizó la prueba de Mc Nemar para comparar los grados de claudicación y respuestas a la flexión forzada, observados durante el 5to control, obtenidos luego de aplicar EMAR y TENS, y no se encontraron diferencias significativas entre ambos tratamientos (p=0,2568. También, se comparó el resultado del Test del Tarso (Test de Churchill luego de aplicar EMAR y TENS, con la prueba de Mc Nemar, no encontrándose diferencias significativas entre ambos (p= 0,7055. Se determina que hay muy poca diferencia entre ambos tratamientos fisioterápicos, observándose una disminución importante a partir del control 2. De estos resultados podemos inferir que ambos métodos pueden utilizarse con éxito en forma indistinta, seleccionándolos de acuerdo con las ventajas y desventajas de su aplicación.A clinical model was designed in order to compare the analgesic effects of TENS (transcutaneous electrical neuromuscular stimulation and RAME (reflex action mechanical electrostimulation, since both methods have been proven effective in equine medicine. The clinical model consisted of 10 horses with a standardized diagnostic protocol of tarsometatarsial degenerative joint disease; these were subjected to both treatments with an interval of 6 months, then results were compared. Treatments were performed every day and the clinic evaluation every two days (five controls. The clinic parameters considered were: a- straight and circle trot, in hard and soft surface. b- Tarsus Flexion test c- Tarsus Test (Churchill test. McNemar's test was performed in order to compare lameness and forced flexion tests at 'control 5' stage, after applying TENS and RAME treatments; no significant differences were found between both treatments (p=0,2568. The Mc Nemar's test also used to compare tarsal flexion tests (Churchill's Test after TENS and RAME treatments, showed no significant differences between Both (p=0,7055. It was therefore concluded that there is little difference between the two methods, while there is an important decrease as from 'control 2'. This situation lets us assume that both methods may be used indistinctly in an effective manner, choosing to use one or the other according to the advantages and disadvantages of its applications.

J.A. García Liñeiro

2006-12-01

48

Comparación de los efectos de dos técnicas de electroanalgesia en la enfermedad articular degenerativa tarsometatarsiana del equino / Comparison between the effects of two electroanalgesical technics in the tarsometatarsal degenerative joint disease  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Se realizó una experiencia para comparar los resultados analgésicos entre TENS (cuyas siglas derivan de la expresión en inglés: transcutaneus electrical neuromuscular stimulation) y el EMAR (estimulación mecánica por acción refleja) de efectividad comprobada en medicina equina, sobre un modelo clíni [...] co de 10 equinos afectados por enfermedad articular degenerativa tarsometatarsiana con un protocolo diagnóstico estandarizado. Sobre la misma población se hicieron los dos tratamientos con intervalos de 6 meses entre uno y otro comparándose luego los resultados. Las aplicaciones en cada tratamiento fueron diarias y el control clínico se realizó post-tratamientos cada dos días (5 controles totales) por los mismos tres profesionales para mantener el mismo esquema de evaluación, considerándose como parámetros: a- Trote en línea recta y en círculo, terreno blando y duro b­Flexión forzada c- Test del tarso (test de Churchill). Se realizó la prueba de Mc Nemar para comparar los grados de claudicación y respuestas a la flexión forzada, observados durante el 5to control, obtenidos luego de aplicar EMAR y TENS, y no se encontraron diferencias significativas entre ambos tratamientos (p=0,2568). También, se comparó el resultado del Test del Tarso (Test de Churchill) luego de aplicar EMAR y TENS, con la prueba de Mc Nemar, no encontrándose diferencias significativas entre ambos (p= 0,7055). Se determina que hay muy poca diferencia entre ambos tratamientos fisioterápicos, observándose una disminución importante a partir del control 2. De estos resultados podemos inferir que ambos métodos pueden utilizarse con éxito en forma indistinta, seleccionándolos de acuerdo con las ventajas y desventajas de su aplicación. Abstract in english A clinical model was designed in order to compare the analgesic effects of TENS (transcutaneous electrical neuromuscular stimulation) and RAME (reflex action mechanical electrostimulation), since both methods have been proven effective in equine medicine. The clinical model consisted of 10 horses wi [...] th a standardized diagnostic protocol of tarsometatarsial degenerative joint disease; these were subjected to both treatments with an interval of 6 months, then results were compared. Treatments were performed every day and the clinic evaluation every two days (five controls). The clinic parameters considered were: a- straight and circle trot, in hard and soft surface. b- Tarsus Flexion test c- Tarsus Test (Churchill test). McNemar's test was performed in order to compare lameness and forced flexion tests at 'control 5' stage, after applying TENS and RAME treatments; no significant differences were found between both treatments (p=0,2568). The Mc Nemar's test also used to compare tarsal flexion tests (Churchill's Test) after TENS and RAME treatments, showed no significant differences between Both (p=0,7055). It was therefore concluded that there is little difference between the two methods, while there is an important decrease as from 'control 2'. This situation lets us assume that both methods may be used indistinctly in an effective manner, choosing to use one or the other according to the advantages and disadvantages of its applications.

García Liñeiro, J.A.; Scipioni, H; Argibay Quiroga, M.T.; Petrone, N.; Pidal, G.; Roccatagliata, C.; Spina, J.; Vaccaro, M..

49

Neuro degenerative diseases: clinical concerns; Les maladies neuro-degeneratives: problemes cliniques  

Energy Technology Data Exchange (ETDEWEB)

Idiopathic Parkinson's disease (PD) and Alzheimer's disease (AD) are the main neuro-degenerative diseases (NDDs) seen clinically. They share some common clinical symptoms and neuro-pathological findings. The increase of life expectancy in the developed countries will inevitably contribute to enhance the prevalence of these diseases. Behavioral disorders, common in NDDs, will produce major care management challenges. Idiopathic Parkinson's disease corresponds to a histopathological diagnosis, based on the observation of a de-pigmentation and a neuronal loss in the substantia nigra, as well as on the presence of intra-neuronal inclusion bodies. AD is insidious with slowly progressive dementia in which the decline in memory constitutes the main complaint. The diagnosis of definite AD requires the presence of clinical criteria as well as the histopathological confirmation of brain lesions. The two main lesions are the presence of senile plaques and neuro-fibrillary tangles. Positron emission tomography (PET) explores cerebral metabolism and neurotransmitter kinetics in NDDs using principally [{sup 18}F]-deoxyglucose and [{sup 18}F]-dopa. Nigrostriatal dopaminergic function is altered in PD, as evidenced by the low uptake of [{sup 18}F]-dopa in the posterior putamen as compared to anterior putamen and caudate nucleus. In contrast, [{sup 18}F]-dopa uptake is equally depressed in all striatal structures in progressive supra-nuclear palsy. Regional glucose metabolism at rest is preserved in elderly once cerebral atrophy is taken into account. On the contrary, glucose metabolism is globally reduced in AD, with marked decrease in the parietal and temporal regions. PET has proved to be useful to study in vivo neurochemical processes in patients suffering from NDDs. The potential of this approach is still largely unexploited, and depends on new ligand production to establish early diagnosis and treatment follow-up. (author)

Ibanez, V. [Hopitaux Universitaires de Geneve (HUG), Unite de Neuroimagerie, Dept. de Psychiatrie (Switzerland)

2005-04-15

50

Bone and joint symptoms in Paget's disease.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fifty patients with Paget's disease of bone were reviewed with regard to the basis of their symptoms and the long-term results of treatment. Twenty-four patients (48%) presented with pain localised within bone, while 17 (34%) presented with symptoms of degenerative joint disease. Three patients presented with bone pain and arthritis and the remaining six with fractures, ataxia, or painless deformity. Symptomatic osteoarthritis of the hip (OA) developed in 25 patients (50%) with approximately ...

Winfield, J.; Stamp, T. C.

1984-01-01

51

Basic Aspects in MR Imaging of Degenerative Lumbar Disk Disease.  

Science.gov (United States)

Degenerative disease may lead to spinal canal stenosis and long-lasting pain. It is among the leading cause of disability that may affect the ability to work. It has become more common in an increasingly aging population. MRI is the most comprehensive imaging modality and provides detailed morphologic information. A standardized terminology facilitates communication with referring physicians. Yet imaging findings need careful interpretation in conjunction with the results of clinical tests and symptoms to truly help guide therapeutic decision making. This review summarizes aspects of normal anatomy of the intervertebral disk, pathologic mechanisms, terminology, and examples of the imaging spectrum of disk degeneration and herniation. PMID:24896740

Heuck, Andreas; Glaser, Christian

2014-07-01

52

Nuclear microscopy in medical research. Investigations into degenerative diseases  

Energy Technology Data Exchange (ETDEWEB)

The high energy (1-4MeV) focused ion beam (nuclear microbeam) has found uses in many scientific disciplines through a wide variety of ion beam based techniques. Of the many techniques available, the powerful combination of Particle Induced X-Ray Emission (PIXE), Rutherford Backscattering Spectrometry (RBS), and Scanning Transmission Ion Microscopy (STIM) is proving to be extremely useful, particularly in the characterisation and elemental analysis of thin specimens. In this paper we briefly review these ion beam techniques, as well as the hardware required for their application. Finally, we describe the application of the PIXE, RBS and STIM techniques in conjunction with a scanning focused 2MeV proton microbeam (nuclear microscopy). The examples chosen to illustrate the potential of nuclear microscopy are recent investigations into the degenerative diseases atherosclerosis (coronary heart disease), Parkinson`s disease and Alzheimer`s disease. (author)

Makjanic, J.; Thong, P.; Watt, F. [National University of Singapore (Singapore). Dept. of Physics

1997-03-01

53

MRI of degenerative lumbar spine disease: comparison of non-accelerated and parallel imaging  

Energy Technology Data Exchange (ETDEWEB)

Parallel imaging techniques such as GRAPPA have been introduced to optimize image quality and acquisition time. For spinal imaging in a clinical setting no data exist on the equivalency of conventional and parallel imaging techniques. The purpose of this study was to determine whether T1- and T2-weighted GRAPPA sequences are equivalent to conventional sequences for the evaluation of degenerative lumbar spine disease in terms of image quality and artefacts. In patients with clinically suspected degenerative lumbar spine disease two neuroradiologists independently compared sagittal GRAPPA (acceleration factor 2, time reduction approximately 50%) and non-GRAPPA images (25 patients) and transverse GRAPPA (acceleration factor 2, time reduction approximately 50%) and non-GRAPPA images (23 lumbar segments in six patients). Comparative analyses included the minimal diameter of the spinal canal, disc abnormalities, foraminal stenosis, facet joint degeneration, lateral recess, nerve root compression and osteochondrotic vertebral and endplate changes. Image inhomogeneity was evaluated by comparing the nonuniformity in the two techniques. Image quality was assessed by grading the delineation of pathoanatomical structures. Motion and aliasing artefacts were classified from grade 1 (severe) to grade 5 (absent). There was no significant difference between GRAPPA and non-accelerated MRI in the evaluation of degenerative lumbar spine disease (P > 0.05), and there was no difference in the delineation of pathoanatomical structures. For inhomogeneity there was a trend in favour of the conventional sequences. No significant artefacts were observed with either technique. The GRAPPA technique can be used effectively to reduce scanning time in patients with degenerative lumbar spine disease while preserving image quality. (orig.)

Noelte, Ingo; Gerigk, Lars; Brockmann, Marc A.; Kemmling, Andre; Groden, Christoph [Medical Faculty Mannheim of the University of Heidelberg, Department of Neuroradiology, Mannheim (Germany)

2008-05-15

54

Cognitive deficits in non-Alzheimer's degenerative diseases.  

Science.gov (United States)

Although observed in various brain disorders, dementia is particularly frequent in neurodegenerative diseases. Alzheimer's disease is characterized by the association of progressive amnesia with either instrumental (aphasia, apraxia, agnosia) or behavioral (apathy, indifference, anosognosia) disorders, depending upon the location of the underlying neuronal lesions. By contrast, memory, linguistic, praxic, visuo-spatial or comportemental impairments are dissociated in more focal "lobar" atrophies, while planning and retrieval deficits predominate in movement disorders with dementia. Alzheimer's and non-Alzheimer's neurodegenerative diseases can therefore be distinguished insofar as the severity and location of the associated neuronal lesions differ. Dementia may be observed in various brain diseases, either vascular, metabolic, demyelinating, traumatic, infectious, inflammatory, neoplastic or hydrocephalus (Chui, 1989). It is particularly frequent in neurodegenerative diseases. The recent clinical description of focal lobar atrophies (Weintraub and Mesulam, 1993) and the analysis of cognitive impairment observed in diseases with movement disorders (Cummings and Benson, 1984) have changed the conception of dementia, that may no more be defined as a global deterioration of higher cortical functions. The relative specificity of the cognitive picture of each disease depends on the location of the underlying neuronal lesions. Together with other tools, such as the neurological examination or the functional imagery, the neuropsychological exam may contribute to characterize the clinical picture of a patient with non-Alzheimer's degenerative disease and therefore to determine a clinical diagnosis, that remains probable till the neuropathological confrontation. PMID:8841957

Pillon, B; Dubois, B; Agid, Y

1996-01-01

55

Imaging techniques for diagnosis after surgery for degenerative disc disease  

International Nuclear Information System (INIS)

The magnetic resonance imaging findings recorded in patients after surgery for degenerative disc disease in the lumbar and cervical spine are discussed in comparison with conventional radiographs and computed tomography findings. In the lumbar spine normal postoperative findings in the immediate postoperative period can be demonstrated by MR imaging. Contrast-enhanced MR imaging can differentiate disc herniation from postoperative scar formation with a greater degree of confidence than other imaging modalities. MR imaging improves differentiation between other causes of failed back syndrome such as postoperative hematoma and infection, lateral spinal stenosis and arachnoiditis. In the cervical spine types of operative approaches, the appearance of bony stenosis and disc herniations by MR imaging are discussed. Computer tomography still has a role in the assessment of osseous complications such as central or foraminal stenosis. (orig.)

1993-10-01

56

[Free radicals and degenerative diseases of the nervous system].  

Science.gov (United States)

Degenerative diseases of the nervous system which are considered to be related to free radicals are Parkinson's disease and Alzheimer-type dementia (ATD). Parkinson's disease is characterized by appearance of Leyw's body and degeneration of nigrostriatal dopaminergic system. But the most fundamental cause of this disease remains still unknown. The fact that H2O2 is formed in the process of oxidative deamination of catecholamines and some substances which can cause Parkinsonism in animal experiments also produce active oxygen in the metabolic processes suggest the important role of free radicals in the pathogenesis of Parkinson's disease. We recently observed that addition of DOPA and Fe3(+)-ADP complex to the microsomal phospholipid system produced lipid peroxides without participation of active oxygen. Neurons cultured in vitro also decreased significantly with addition of DOPA and Fe3(+)-ADP complex and this harmful effect was prevented by desferoxamine (potent Fe chelating agent) or alpha-tocopherol (antioxidant). These results may suggest that lipid peroxidation can occur by interaction of naturally existing substances in the dopaminergic system and induce cell damage. As regards ATD, there is still no definite evidence to support the implication of free radicals in its pathogenesis. However, there are reports that lipid peroxides increase significantly in the brains of patients with ATD. Moreover, recent advances in the study of amyloid in the senile plaque revealed close relationship of ATD to chromosome 21.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2200916

Hirai, S; Tanaka, M; Sotomatsu, A

1990-03-01

57

Lumbar Disc Degenerative Disease: Disc Degeneration Symptoms and Magnetic Resonance Image Findings  

Science.gov (United States)

Study Design Cross sectional and observational. Purpose To evaluate the different aspects of lumbar disc degenerative disc disease and relate them with magnetic resonance image (MRI) findings and symptoms. Overview of Literature Lumbar disc degenerative disease has now been proven as the most common cause of low back pain throughout the world. It may present as disc herniation, lumbar spinal stenosis, facet joint arthropathy or any combination. Presenting symptoms of lumbar disc degeneration are lower back pain and sciatica which may be aggravated by standing, walking, bending, straining and coughing. Methods This study was conducted from January 2012 to June 2012. Study was conducted on the diagnosed patients of lumbar disc degeneration. Diagnostic criteria were based upon abnormal findings in MRI. Patients with prior back surgery, spine fractures, sacroiliac arthritis, metabolic bone disease, spinal infection, rheumatoid arthritis, active malignancy, and pregnancy were excluded. Results During the targeted months, 163 patients of lumbar disc degeneration with mean age of 43.92±11.76 years, came into Neurosurgery department. Disc degeneration was most commonly present at the level of L4/L5 105 (64.4%).Commonest types of disc degeneration were disc herniation 109 (66.9%) and lumbar spinal stenosis 37 (22.7%). Spondylolisthesis was commonly present at L5/S1 10 (6.1%) and associated mostly with lumbar spinal stenosis 7 (18.9%). Conclusions Results reported the frequent occurrence of lumbar disc degenerative disease in advance age. Research efforts should endeavor to reduce risk factors and improve the quality of life.

Saleem, Shafaq; Rehmani, Muhammad Asim Khan; Raees, Aisha; Alvi, Arsalan Ahmad; Ashraf, Junaid

2013-01-01

58

Degenerative knee joint lesions in mice after a single intra-articular collagenase injection. A new model of osteoarthritis.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A single intra-articular injection with bacterial collagenase in the right knee joints of 10-week-old male C57bl10 mice led to osteoarthritic lesions within a few weeks in these joints. The collagenase-induced osteoarthritis was characterized by severe degenerative cartilage lesions on the medial side of the femorotibial joint associated with patellar dislocation to the medial side of the joint, sclerosis of subchondral bone below the cartilage erosions, osteophyte formation, and consequent d...

Kraan, P. M.; Vitters, E. L.; Beuningen, H. M.; Putte, L. B.; Den Berg, W. B.

1990-01-01

59

Potential of Bone Marrow Stromal Cells in Applications for Neuro-Degenerative, Neuro-Traumatic and Muscle Degenerative Diseases  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Cell transplantation is a promising strategy for the treatment of neurodegenerative and muscle degenerative diseases. Many kinds of cells, including embryonic stem cells and tissue stem cells, have been considered as candidates for transplantation therapy. Bone marrow stromal cells (MSCs) have great potential as therapeutic agents since they are easy to isolate and can be expanded from patients without serious ethical or technical problems. We discovered a new method for the highly efficient ...

Dezawa, Mari; Ishikawa, Hiroto; Hoshino, Mikio; Itokazu, Yutaka; Nabeshima, Yo-ichi

2005-01-01

60

The value of fat saturation sequences and contrast medium administration in MRI of degenerative disease of the posterior/perispinal elements of the lumbosacral spine  

Energy Technology Data Exchange (ETDEWEB)

Degenerative-inflammatory lumbar spinal pathology is one of the most common reasons why individuals seek medical care, and low back pain is the main symptom among those most commonly associated with this pathologic condition. Pain is commonly attributed to degenerative disc disease, particularly herniated discs, but many different spinal and perispinal structures may undergo degenerative-inflammatory phenomena and produce pain: discs, bone, facet joints, ligaments and muscles. In particular, in patients with non-radicular low back pain, this syndrome may arise from changes of the posterior elements/perispinal tissues of the lumbar spine (i.e., the ''posterior vertebral compartment''). They include: facet joint pathology (e.g., osteoarthritis, joint effusion, synovitis and synovial cysts), spondylolysis, spinal/perispinal ligamentous degenerative-inflammatory changes and perispinal muscular changes. It is well known that magnetic resonance is the most sensitive imaging method for the evaluation of spinal degenerative pathology, even in the initial stages of the disease. T2-weighted sequences with fat saturation, and when indicated the use of contrast-enhanced T1-weighted images with fat saturation, permit the visualization of degenerative-inflammatory changes of the posterior elements of the lumbar spine that in most cases would have been overlooked with conventional non-fat suppressed imaging. (orig.)

D' Aprile, P. [San Paolo Hospital, Department of Neuroradiology, Bari (Italy); U.O. Radiologia, Sezione di Neuroradiologia, Ospedale ' ' S. Paolo' ' , Via Caposcardicchio, Bari (Italy); Tarantino, A. [San Paolo Hospital, Department of Neuroradiology, Bari (Italy); Jinkins, J.R. [State University of New York, Department of Radiology, Downstate Medical Center, Brooklyn, NY (United States); Brindicci, D. [San Paolo Hospital, Department of Radiology, Bari (Italy)

2007-02-15

 
 
 
 
61

Prevalence of AIPL1 mutations in inherited retinal degenerative disease.  

Science.gov (United States)

Leber congenital amaurosis (LCA) is the most severe form of inherited retinal dystrophy and the most frequent cause of inherited blindness in children. LCA is usually inherited in an autosomal recessive fashion, although rare dominant cases have been reported. One form of LCA, LCA4, maps to chromosome 17p13 and is genetically distinct from other forms of LCA. We recently identified the gene associated with LCA4, AIPL1 (aryl-hydrocarbon interacting protein-like 1) and identified three mutations that were the cause of blindness in five families with LCA. In this study, AIPL1 was screened for mutations in 512 unrelated probands with a range of retinal degenerative diseases to determine if AIPL1 mutations cause other forms of inherited retinal degeneration and to determine the relative contribution of AIPL1 mutations to inherited retinal disorders in populations worldwide. We identified 11 LCA families whose retinal disorder is caused by homozygous or compound heterozygous AIPL1 mutations. We also identified affected individuals in two apparently dominant families, diagnosed with juvenile retinitis pigmentosa or dominant cone-rod dystrophy, respectively, who are heterozygous for a 12-bp AIPL1 deletion. Our results suggest that AIPL1 mutations cause approximately 7% of LCA worldwide and may cause dominant retinopathy. PMID:10873396

Sohocki, M M; Perrault, I; Leroy, B P; Payne, A M; Dharmaraj, S; Bhattacharya, S S; Kaplan, J; Maumenee, I H; Koenekoop, R; Meire, F M; Birch, D G; Heckenlively, J R; Daiger, S P

2000-06-01

62

Mesenchymal stem cell therapy in joint disease.  

Science.gov (United States)

Mesenchymal stem cells have the capacity to differentiate into a variety of connective tissue cells including bone, cartilage, tendon, muscle and adipose tissue. These multipotent cells have been isolated from bone marrow and from other adult tissues including skeletal muscle, fat and synovium. Because of their multipotentiality and capacity for self renewal adult stem cells may represent units of active regeneration of tissues damaged as a result of trauma or disease. In certain degenerative diseases such as osteoarthritis (OA) stem cells are depleted, and have reduced proliferative capacity and reduced ability to differentiate. The delivery of stem cells to these individuals may therefore enhance repair or inhibit the progressive destruction of the joint. We have developed methods for the delivery of mesenchymal stem cell preparations taken from bone marrow to the injured knee joint. This treatment has the potential to stimulate regeneration of cartilage and retard the progressive destruction of the joint that typically occurs following injury. PMID:12708651

Barry, Frank P

2003-01-01

63

Frying process in the relation fat/degenerative diseases.  

Directory of Open Access Journals (Sweden)

Full Text Available Among the various components of the diet, fat receives very dose attention because of its relationship to several chronic degenerative diseases (CDD. Currently most of the available information on these relationships is derived from epidemiologic or experimental studies in which lipid intake is calculated using food composition tables. In most of these tables the quoted lipid content is that of raw food, whereas most foods are usually consumed only after being subjected to several culinary processes. Often there is no indication of the type of fat used in food processing in general or in frying in particular. But as it known, in the course of these processes the lipid content undergoes important qualitative and quantitative changes and not keeping them in mind may be the underlying cause of the difficulties an the confounding results in studies trying to establish the relationship between lipid intake an health. In the Mediterranean diet, about 50% of total dietary fat is derived not from the food itself but from the cooking fat, of which only a small fraction is eaten raw (as dressings and the greatest proportion is used in thermal culinary processes, mainly deep-frying. The scientific study of the process whereby fat penetrates into fried foods has shown the benefits of this cooking method. If the process is correctly carried out, the amount of fat ingested with fried foodstuffs is not greater than when other procedures involving fat are used (for example, sautening, stewing or canning in oil. Very schematically deep-frying is a technique that replaces a fraction of the water content of food by cooking fat. Consecuently, the fat composition of the fried lean foods will be the same as that cooking fat. The process is more complex with fatty foods, and there are not great changes in the total quantity of fat in the fried food before and after frying. However, there are notable quality changes and these depend on the concentration gradients between frying oil and food. In deep-frying the cooking fat is usually used more than once, and there comes a moment when one considers subjectively that the oil is not longer suitable for frying and is discarded. This can be of practical significance for the total lipid intake, since a not determined quantity of oil is discarded and is not ingested. Consecuently the theoretical lipid intake has been decreased and, at the same time, some compounds, included saturated fats, are eliminated from diet whit the discarded oil. For example, the lipid composition of meats is substantially improved because of the highly favorable monounsaturated fatty acids penetration into them from the frying olive oil. In of the most important features is the possibility of manipulating fat intake by reducing it and improving the quality of the fat really consumed, this is of special interest in the possible relation to degenerative diseases. These changes in the fatty acids composition of oils and foods are repeatedly seen in laboratory experiments. However, their interpretation is not easy, in part because of the complexity of the deep-frying process used in the test. On the other hand, you would have to see the results obtained in the laboratory coincide with the results at practical level as well in the households as in catering, and, in this sense, some of the first results which we are obtaining in the population of Madrid are presented in the second part of this report.

Varela, G.

1998-08-01

64

Laser technologies in treatment of degenerative-dystrophic bone diseases in children  

Science.gov (United States)

Two low invasive laser technologies for treatment of degenerative-dystrophic bone diseases in children are presented. The first is the transcutaneous laser osteoperforation developed by us and initially applied for treatment of different inflammatory and traumatic diseases (osteomyelitides, osteal and osteoarticular panaritiums, delayed unions, false joints, and others). Now the technology was applied to treatment of aseptic osteonecrosis of different localizations in 134 children aged from 1 to 16 years, including 56 cases with necrosis of femoral head (Legg-Calve-Perthes disease), 42 with necrosis of 2nd metatarsal bone head (Kohler II disease), and 36 with necrosis of tibial tuberosity (Osgood-Schlatter disease). The second technology is the laser intracystic thermotherapy for treatment of bone cysts. The method was applied to 108 children aged from 3 to 16 years with aneurismal and solitary cysts of different localizations. In both technologies a 970 nm diode laser was used. The suggested technologies increase the efficiency of treatment, reduce its duration, can be performed on outpatient basis, which resulted in great economical effect.

Abushkin, Ivan A.; Privalov, Valery A.; Lappa, Alexander V.; Noskov, Nikolay V.; Neizvestnykh, Elena A.; Kotlyarov, Alexander N.; Shekunova, Yulia G.

2014-03-01

65

Investigation of joint disease  

International Nuclear Information System (INIS)

Diseases affecting joints are among the most common of non-lethal but severely disabling conditions. The role of radioactive tracers in their management, although limited, has recently been reviewed from a number of viewpoints (Kim 1989; Datz 1990). Even though the majority of patients with arthropathies never require isotope investigations, there remain many situations in which radioisotope techniques can provide clinically important information not otherwise available or accessible, principally in the identification of complications of surgery and the assessment of disease activity or extent (Kaye 1990). Further developments, and the dictates of iconoclasm, justify a further reevaluation of this topic. (orig.)

1992-01-01

66

Anatomical basics, variations, and degenerative changes of the shoulder joint and shoulder girdle  

Energy Technology Data Exchange (ETDEWEB)

This paper summarizes the anatomical basics of the shoulder, their variations, and precise definitions, including differential diagnoses. It also describes the characteristic degenerative changes caused by aging. A typical variation (7-15%) is the os acromiale, which forms the triangular epiphysis of the scapular spine. This abnormality must be differentiated from a fracture of the acromion or a pseudarthrosis. Because ossification of the acromion is complete after age 25, the os acromiale should be diagnosed only after this age. The shape of the acromion is a further important feature. In a recent anatomical study, the following frequencies of the Bigliani-types of the acromial shape were anatomically determined - type 1 (flat), 10.2% and type 2 (curved), 89.8%. Type 3 (hooked) was not observed, which indicates that this type is probably a misinterpretation of the so-called acromial spur. Minor dehiscences and perforations in the infraspinate or supraspinate fossa should not be confused with malignant osteolyses. The scapula has three ligaments of its own, (1) the coracoacromial ligament and its osseous fixations form an osteofibrous arch above the shoulder joint, which plays a part in impingement syndrome; (2) the superior transverse scapular ligament or its ossified correlate arches the scapular incisure and can cause a typical compression syndrome of the suprascapular nerve; (3) the inferior transverse scapular ligament is of no great clinical importance. Two intraarticular structures (glenoid labrum and tendon of the long bicipital head) must be mentioned. The glenoid labrum consists of dense connective tissue and surrounds the margin of the glenoid cavity. Two areas exhibit specialized conditions, cranial at the supraglenoid tubercle an intimate relationship exists to the tendon of the long bicipital head and in about 55% of cases, the labrum is stretched over the glenoid rim at the ventral side. At the area of the biceps-tendon-labrum complex, so-called SLAP-lesions may occur and at the glenoid rim, where the labrum is often not fixed to the bony margin, avulsions of the labrum may occur. This well-established anatomical condition must not be mistaken for a manifest Bankart-lesion. The glenohumeral ligaments, which are located in the ventral articular capsule, have a stabilizing function for the ventral part of the glenoid labrum. The glenohumeral ligaments lift the articular lip where it crosses the glenoid notch. This 'labrum-lift effect' supports the stabilizing features of the articular lip and the glenohumeral ligaments. The rotator cuff is composed of the tendons of the teres minor, infraspinatus, supraspinatus, and subscapularis muscles. This cuff has a poorly vascularized area, due to mechanical conditions, about 1.5 cm from the major tubercle, which causes degenerative changes and eventually may lead to ruptures. Results of the impingement-syndrome and the osteoarthrotic changes of the shoulder and acromioclavicular joint are also presented and discussed. Finally, the coracoclavicular joint, which probably represents no congenital entity but appears due to a changed, lowered position of the shoulder girdle, is discussed. The paper also presents instructive figures of anatomical preparations that can be used to make more precise radiological and differential diagnoses. All preparations were done by the author and are part of a series of more than 300 preparations of the shoulder joint and girdle.

Prescher, Andreas E-mail: dkeyserlingk@post.klinikum.rwth-aachen.de

2000-08-01

67

Anatomical basics, variations, and degenerative changes of the shoulder joint and shoulder girdle  

International Nuclear Information System (INIS)

This paper summarizes the anatomical basics of the shoulder, their variations, and precise definitions, including differential diagnoses. It also describes the characteristic degenerative changes caused by aging. A typical variation (7-15%) is the os acromiale, which forms the triangular epiphysis of the scapular spine. This abnormality must be differentiated from a fracture of the acromion or a pseudarthrosis. Because ossification of the acromion is complete after age 25, the os acromiale should be diagnosed only after this age. The shape of the acromion is a further important feature. In a recent anatomical study, the following frequencies of the Bigliani-types of the acromial shape were anatomically determined - type 1 (flat), 10.2% and type 2 (curved), 89.8%. Type 3 (hooked) was not observed, which indicates that this type is probably a misinterpretation of the so-called acromial spur. Minor dehiscences and perforations in the infraspinate or supraspinate fossa should not be confused with malignant osteolyses. The scapula has three ligaments of its own, (1) the coracoacromial ligament and its osseous fixations form an osteofibrous arch above the shoulder joint, which plays a part in impingement syndrome; (2) the superior transverse scapular ligament or its ossified correlate arches the scapular incisure and can cause a typical compression syndrome of the suprascapular nerve; (3) the inferior transverse scapular ligament is of no great clinical importance. Two intraarticular structures (glenoid labrum and tendon of the long bicipital head) must be mentioned. The glenoid labrum consists of dense connective tissue and surrounds the margin of the glenoid cavity. Two areas exhibit specialized conditions, cranial at the supraglenoid tubercle an intimate relationship exists to the tendon of the long bicipital head and in about 55% of cases, the labrum is stretched over the glenoid rim at the ventral side. At the area of the biceps-tendon-labrum complex, so-called SLAP-lesions may occur and at the glenoid rim, where the labrum is often not fixed to the bony margin, avulsions of the labrum may occur. This well-established anatomical condition must not be mistaken for a manifest Bankart-lesion. The glenohumeral ligaments, which are located in the ventral articular capsule, have a stabilizing function for the ventral part of the glenoid labrum. The glenohumeral ligaments lift the articular lip where it crosses the glenoid notch. This 'labrum-lift effect' supports the stabilizing features of the articular lip and the glenohumeral ligaments. The rotator cuff is composed of the tendons of the teres minor, infraspinatus, supraspinatus, and subscapularis muscles. This cuff has a poorly vascularized area, due to mechanical conditions, about 1.5 cm from the major tubercle, which causes degenerative changes and eventually may lead to ruptures. Results of the impingement-syndrome and the osteoarthrotic changes of the shoulder and acromioclavicular joint are also presented and discussed. Finally, the coracoclavicular joint, which probably represents no congenital entity but appears due to a changed, lowered position of the shoulder girdle, is discussed. The paper also presents instructive figures of anatomical preparations that can be used to make more precise radiological and differential diagnoses. All preparations were done by the author and are part of a series of more than 300 preparations of the shoulder joint and girdle

2000-08-01

68

Computer tomography of inflammatory rheumatic degenerative and reparative affections and transformation processes in the region of the sacroiliac joints  

International Nuclear Information System (INIS)

Inflammatory rheumatic, degenerative and reparative affections and transformation processes in the region of the sacroiliac joints can be demonstrated via computer tomography and/or conventinal roentgenology. It is found that computer tomography is superior to plain roentgenography diagnosis, including tomography, in respect of malpositioning of the articulating bones and reparative phenomena. On the other hand, early diagnosis of inflammatory rheumatic changes does not yield any additional information via computer tomography. (orig.)

1980-01-01

69

Artificial chordae for degenerative mitral valve disease: critical analysis of current techniques  

Science.gov (United States)

The surgical repair of degenerative mitral valve disease involves a number of technical points of importance. The use of artificial chordae for the repair of degenerative disease has increased as a part of the move from mitral valve replacement to repair of the mitral valve. The use of artificial chordae provides an alternative to the techniques pioneered by Carpentier (including the quadrangular resection, transfer of native chordae and papillary muscle shortening/plasty), which can be more technically difficult. Despite a growth in their uptake and the indications for their use, a number of challenges remain for the use of artificial chordae in mitral valve repair, particularly in the determination of the correct length to ensure optimal leaflet coaptation. Here, we analyse over 40 techniques described for artificial chordae mitral valve repair in the setting of degenerative disease.

Ibrahim, Michael; Rao, Christopher; Athanasiou, Thanos

2012-01-01

70

Cerebral atrophic and degenerative changes following various cerebral diseases, (1)  

International Nuclear Information System (INIS)

Patients having cerebral atrophic and degenerative changes following hypoglycemia, cerebral contusion, or cerebral hypoxia including cerebrovascular disorders were reported. Description was made as to cerebral changes visualized on CT images and clinical courses of a patient who revived 10 minutes after heart stoppage during neurosurgery, a newborn with asphyxia, a patient with hypoglycemia, a patient who suffered from asphyxia by an accident 10 years before, a patient with carbon monoxide poisoning at an acute stage, a patient who had carbon monoxide poisoning 10 years before, a patient with diffuse cerebral ischemic changes, a patient with cerebral edema around metastatic tumor, a patient with respiration brain, a patient with neurological sequelae after cerebral contusion, a patient who had an operation to excise right parietal lobe artery malformation, and a patient who was shooted by a machine gun and had a lead in the brain for 34 years. (Tsunoda, M.)

1980-01-01

71

Sulfato de condroitina e hialuronato de sódio no tratamento da doença articular degenerativa em cães: estudo histológico da cartilagem articular e membrana sinovial / Chondroitin sulfate and sodium hyaluronate in the treatment of the degenerative joint disease in dogs: histological features of articular cartilage and synovium  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Quinze cães, sem raça definida, de ambos os sexos, de peso entre 18 e 25kg, foram submetidos à secção artroscópica do ligamento cruzado cranial (LCCr) para indução da doença articular degenerativa (DAD). Após três semanas de instabilidade articular, o LCCr foi substituído pela fáscia lata segundo a [...] técnica de Schwalder (1989) e os animais foram distribuídos em três grupos de cinco. Os animais do grupo I, controle, não receberam tratamento medicamentoso; os do grupo II, 24mg/animal de sulfato de condroitina, por via IM, de cinco em cinco dias, totalizando seis aplicações; e os do grupo III foram tratados com hialuronato de sódio na dose de 20mg/animal, por via IV, de cinco em cinco dias num total de três administrações. Ao final de 90 dias, os animais foram eutanasiados e procedeu-se à colheita e ao processamento histológico da membrana sinovial e da cartilagem articular para avaliações morfológica e morfométrica. No grupo I foram observadas alterações degenerativas de DAD mais acentuadas que nos demais grupos, como redução do número de condrócitos, presença de pânus, fibrilações, fissuras, erosões e irregularidades na superfície articular. No grupo II observou-se elevação do número de condrócitos com aumento da atividade de síntese da matriz e redução das lesões na superfície da cartilagem. No grupo III houve aumento do número de condrócitos que eram, muitas vezes, morfologicamente inviáveis. Todos os grupos apresentaram proliferação da membrana sinovial e presença de infiltrado linfoplasmocitário na subíntima e na perivascular. Nos grupos I e III, a proliferação da membrana sinovial era exuberante com formação de pânus, presença de sinoviócitos achatados ou ausência de sinóvia com tecido de granulação. Os resultados sugerem que o sulfato de condroitina estimulou a cartilagem articular, diminuindo ou retardando as alterações da DAD e o hialuronato de sódio não interferiu no processo degenerativo da cartilagem articular. Não foi constatada ação favorável das drogas na membrana sinovial. Abstract in english Fifteen mongrel dogs, both genders, weighting from 18 to 25kg were used and Degenerative Joint Disease (DJD) was induced through cranial cruciate ligament (CCrL) artroscopical section. After three weeks, CCrL was reconstructed by Schawalder's (1989) technique. Then, dogs were distributed in three gr [...] oups and the following protocols were used: group I, control, no other treatment but the CCrL reconstruction; group II received chondroitin sulfate 24mg per animal every five days, intramuscularly, in a total of six injections; and group III received sodium hyaluronate 20mg per animal every five days, intravenously, in a total of three injections. Clinical observation was done until 90 days after treatments. By that time, the articular cartilage and synovium were collected and their morphology was evaluated. In group I, the degenerative alterations of the DJD were the most intense. Thus, decrease of chondrocytes number, pannus, fibrillations, grooves, erosion, and irregular articular surface were observed on the cartilage. In group II, raise of chondrocytes number was observed, with increase of synthesis activity of matrix and decrease of lesions on the articular surface. There was an increase of chondrocytes in group III, but the cells were morphologically unviable. All the groups showed proliferation of the synovial membrane, with limpho-plasma cells infiltrated in subintim and perivascular. In groups I and III, the proliferation of synovium was abundant, with formation of pannus, flattened synoviocytes or synovium absent with granulation tissue. Those results suggest that the chondroitin sulfate stimulated the articular cartilage; decreasing or delaying the alterations of DJD, as well as, the sodium hyaluronate did not interfere on degenerative process in articular cartilage. No favorable action of these drugs in the synovial membrane was verified.

E.G., Melo; V.A., Nunes; C.M.F., Rezende; M.G., Gomes; C., Malm; V.A., Gheller.

72

Sulfato de condroitina e hialuronato de sódio no tratamento da doença articular degenerativa em cães: estudo histológico da cartilagem articular e membrana sinovial Chondroitin sulfate and sodium hyaluronate in the treatment of the degenerative joint disease in dogs: histological features of articular cartilage and synovium  

Directory of Open Access Journals (Sweden)

Full Text Available Quinze cães, sem raça definida, de ambos os sexos, de peso entre 18 e 25kg, foram submetidos à secção artroscópica do ligamento cruzado cranial (LCCr para indução da doença articular degenerativa (DAD. Após três semanas de instabilidade articular, o LCCr foi substituído pela fáscia lata segundo a técnica de Schwalder (1989 e os animais foram distribuídos em três grupos de cinco. Os animais do grupo I, controle, não receberam tratamento medicamentoso; os do grupo II, 24mg/animal de sulfato de condroitina, por via IM, de cinco em cinco dias, totalizando seis aplicações; e os do grupo III foram tratados com hialuronato de sódio na dose de 20mg/animal, por via IV, de cinco em cinco dias num total de três administrações. Ao final de 90 dias, os animais foram eutanasiados e procedeu-se à colheita e ao processamento histológico da membrana sinovial e da cartilagem articular para avaliações morfológica e morfométrica. No grupo I foram observadas alterações degenerativas de DAD mais acentuadas que nos demais grupos, como redução do número de condrócitos, presença de pânus, fibrilações, fissuras, erosões e irregularidades na superfície articular. No grupo II observou-se elevação do número de condrócitos com aumento da atividade de síntese da matriz e redução das lesões na superfície da cartilagem. No grupo III houve aumento do número de condrócitos que eram, muitas vezes, morfologicamente inviáveis. Todos os grupos apresentaram proliferação da membrana sinovial e presença de infiltrado linfoplasmocitário na subíntima e na perivascular. Nos grupos I e III, a proliferação da membrana sinovial era exuberante com formação de pânus, presença de sinoviócitos achatados ou ausência de sinóvia com tecido de granulação. Os resultados sugerem que o sulfato de condroitina estimulou a cartilagem articular, diminuindo ou retardando as alterações da DAD e o hialuronato de sódio não interferiu no processo degenerativo da cartilagem articular. Não foi constatada ação favorável das drogas na membrana sinovial.Fifteen mongrel dogs, both genders, weighting from 18 to 25kg were used and Degenerative Joint Disease (DJD was induced through cranial cruciate ligament (CCrL artroscopical section. After three weeks, CCrL was reconstructed by Schawalder's (1989 technique. Then, dogs were distributed in three groups and the following protocols were used: group I, control, no other treatment but the CCrL reconstruction; group II received chondroitin sulfate 24mg per animal every five days, intramuscularly, in a total of six injections; and group III received sodium hyaluronate 20mg per animal every five days, intravenously, in a total of three injections. Clinical observation was done until 90 days after treatments. By that time, the articular cartilage and synovium were collected and their morphology was evaluated. In group I, the degenerative alterations of the DJD were the most intense. Thus, decrease of chondrocytes number, pannus, fibrillations, grooves, erosion, and irregular articular surface were observed on the cartilage. In group II, raise of chondrocytes number was observed, with increase of synthesis activity of matrix and decrease of lesions on the articular surface. There was an increase of chondrocytes in group III, but the cells were morphologically unviable. All the groups showed proliferation of the synovial membrane, with limpho-plasma cells infiltrated in subintim and perivascular. In groups I and III, the proliferation of synovium was abundant, with formation of pannus, flattened synoviocytes or synovium absent with granulation tissue. Those results suggest that the chondroitin sulfate stimulated the articular cartilage; decreasing or delaying the alterations of DJD, as well as, the sodium hyaluronate did not interfere on degenerative process in articular cartilage. No favorable action of these drugs in the synovial membrane was verified.

E.G. Melo

2008-02-01

73

METHODS OF OSTEOSYNTHESIS OF ARTICULAR FRACTURES INFLUENCE OVER DEVELOPMENT OF DYSTROPHIC DEGENERATIVE JOINT CHANGES  

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The authors of article suggest the way of treatment limbs fracture of the using to spoke-shank device for external fixation. Such approach allows to reduce risk ofdevelopmentofcomplications anddystrophic degenerative jointchanges.

Beidik, O. V.; Lukpanova, T. N.; Mandrov, D. V.; Litvak, M. B.; Nemalyaev, S. A.; Borodulin, V. ?.; Steklov, A. A.; Shcherbakov, M. A.

2008-01-01

74

Avaliação radiológica e artroscópica e histologia da membrana sinovial do joelho de cães tratados com associação de sulfato de condroitina e hialuronato de sódio, após doença articular degenerativa induzida experimentalmente Radiological, arthroscopical evaluation and synovial membrane histology of the knee of dogs treated with chondroitin sulphate- sodium hialuronate association after experimental degenerative joint disease  

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Full Text Available O presente trabalho objetivou avaliar a associação de hialuronato de sódio e sulfato de condroitina no tratamento da doença articular degenerativa (DAD em cães. Dez cães sem raça definida foram submetidos à secção artroscópica do ligamento cruzado cranial visando o desenvolvimento da DAD. Após 21 dias, foi substituído cirurgicamente o ligamento cruzado cranial em todos os animais e iniciado o tratamento com associação de hialuronato de sódio e sulfato de condroitina em cinco cães, sendo os remanescentes utilizados como grupo-controle. Avaliações artroscópica e radiológica do membro posterior esquerdo foram realizadas antes da secção do ligamento, no dia da sua substituição e 90 dias após a cirurgia. Histologicamente, o efeito da associação de hialuronato de sódio e sulfato de condroitina foi mais evidente na membrana sinovial, observando-se regeneração da camada íntima e diminuição da infiltração linfoplasmocitária na sub-íntima. Artroscópica e macroscopicamente não houve prevenção das lesões cartilaginosas decorrentes da DAD.The aim of this study was the assessment of hyaluronic acid and chondroitin sulphate association in the therapy of degenerative joint disease (DJD in dogs. Ten mongrel dogs underwent arthroscopic section of cruciate cranial ligament aiming the development of DJD. Twenty one days after the procedure, surgical substitution of cruciate cranial ligament was carried out in all animals. Then five animals were treated with the combination of hyaluronic acid and chondroitin sulphate. The other five dogs were used as controls. Arthroscopical and radiological evaluations of the left fore limb were carried out before arthroscopic section at the some day and 90 days after cruciate cranial ligament substitution. Histologically the effect of the association of hyaluronic acid and chondroitin sulphate was more evident in the synovial membrane that had regeneration of the intimal layer and reduced lympho-plasmocitic infiltrate in the sub-intimal layer. However, the treatment did not prevent DJD cartilage lesions evaluated by arthroscopy and radiology.

S.A. Arias S.

2003-08-01

75

Characterization of degenerative changes in the temporomandibular joint of the bengal tiger (Panthera tigris tigris) and siberian tiger (Panthera tigris altaica).  

Science.gov (United States)

The articulation of the temporomandibular joint (TMJ) is composed of the temporal bone dorsally, the mandibular condyle ventrally and a fibrous articular disc. The TMJ disc plays an essential role in distributing load between the two articular surfaces. Degeneration of the disc in the presence of joint pathology has been shown in man; however, TMJ pathology has not been documented previously in tigers (Panthera tigris). The mandibular condyle and TMJ disc of a Bengal tiger (P. tigris tigris) and a Siberian tiger (P. tigris altaica) were evaluated grossly and the TMJ disc was characterized biochemically and mechanically. Characterization of the TMJ disc verified region- and direction-dependent biochemical and mechanical properties, reflective of the functional demands on the joint. Degenerative joint disease was observed in both cases and this was more severe in the Siberian tiger. Simultaneous evaluation of joint pathology, biochemical composition and mechanical properties of the TMJ disc revealed a loss in functional properties (tensile anisotropy) of the disc as joint pathology advanced from moderate to severe. TMJ degeneration may compromise the ability of the animal to eat and thrive and may be a factor contributing to the endangered status of these species. PMID:23809909

Murphy, M K; Arzi, B; Vapniarsky-Arzi, N; Athanasiou, K A

2013-11-01

76

Motor training in degenerative spinocerebellar disease: ataxia-specific improvements by intensive physiotherapy and exergames.  

Science.gov (United States)

The cerebellum is essentially involved in movement control and plays a critical role in motor learning. It has remained controversial whether patients with degenerative cerebellar disease benefit from high-intensity coordinative training. Moreover, it remains unclear by which training methods and mechanisms these patients might improve their motor performance. Here, we review evidence from different high-intensity training studies in patients with degenerative spinocerebellar disease. These studies demonstrate that high-intensity coordinative training might lead to a significant benefit in patients with degenerative ataxia. This training might be based either on physiotherapy or on whole-body controlled videogames ("exergames"). The benefit shown in these studies is equal to regaining one or more years of natural disease progression. In addition, first case studies indicate that even subjects with advanced neurodegeneration might benefit from such training programs. For both types of training, the observed clinical improvements are paralleled by recoveries in ataxia-specific dysfunctions (e.g., multijoint coordination and dynamic stability). Importantly, for both types of training, the retention of the effects seems to depend on the frequency and continuity of training. Based on these studies, we here present preliminary recommendations for clinical practice, and articulate open questions that might guide future studies on neurorehabilitation in degenerative spinocerebellar disease. PMID:24877117

Synofzik, Matthis; Ilg, Winfried

2014-01-01

77

[Current studies on induced pluripotent stem cells in retinal degenerative diseases].  

Science.gov (United States)

Retinal degeneration diseases are a group of severe eye diseases that can lead to blindness. They are characterized by degeneration and apoptosis of photoreceptor cells and still lacking effective therapeutic procedures. Pluripotent stem cells (induced pluripotent stem cells, iPS cells) obtained from somatic cell reprogramming are similar to the embryonic stem cells (embryonic stem cells, ES cells), which have unlimited proliferation, differentiation and memory characteristics. Retinal cells from iPS cells have been used in cell transplantation for the treatment of retinal diseases, for the study of pathogenesis and drug toxicity evaluation in retinal degenerative diseases. This may provide new ideas and novel procedures for the treatment of retinal degenerative diseases in the future. PMID:22800459

Zhu, Jia-li; Zheng, Qin-xiang; Li, Wen-sheng

2012-04-01

78

Efficacy of a Human Amniotic Tissue-derived Allograft, NuCel, in Patients Undergoing Posteriolateral Lumbar Fusions for Degenerative Disc Disease  

Science.gov (United States)

Lumbar Degenerative Disc Disease; Spinal Stenosis; Spondylolisthesis; Spondylosis; Intervertebral Disk Displacement; Intervertebral Disk Degeneration; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Spondylolysis

2014-04-15

79

PET studies in Alzheimer disease and other degenerative dementias  

International Nuclear Information System (INIS)

Neurodegenerative disorders cause a variety of dementia including Alzheimer disease, frontotemporal dementia, dementia with Lewy bodies, corticobasal degeneration, progressive supranuclear palsy, and Huntington's disease. PET scan is useful for early detection and differential diagnosis of theses dementing disorders. Also, it provides valuable information about clinico-anatomical correlation, allowing better understanding of function of brain. Here we discuss recent achievements PET studies regarding these dementing disorders. Future progress in PET technology, new tracers, and image analysis will play an important role in further clarifying the disease pathophysiology and brain functions

2003-02-01

80

Predictive diagnostics and personalized medicine for the prevention of chronic degenerative diseases  

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Abstract Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or neurodegenerative diseases among the elderly. CDD are of complex diagnosis, difficult to treat and absorbing an increasing proportion in the health care budgets worldwide. However, recent development in modern medicine especially in genetics, proteomics, and informatics ...

Licastro Federico; Caruso Calogero

2010-01-01

 
 
 
 
81

Lumbar spine degenerative disease : effect on bone mineral density measurements in the lumbar spine and femoral neck  

International Nuclear Information System (INIS)

To determine the effect of degenerative disease of the lumbar spine on bone mineral density in the lumbar spine and femoral neck. We reviewed radiographs and dual energy x-ray absorptiometry scans of the lumbar spine and hip in 305 Caucasian women with suspected osteoporosis. One hundred and eight-six patient remained after excluding women less than 40 years of age (n=18) and those with hip osteoarthritis, scoliosis, lumbar spine fractures, lumbar spinal instrumentation, hip arthroplasty, metabolic bone disease other than osteoporosis, or medications known to influence bone metabolism (n=101). On the basis of lumbar spine radiographs, those with absent/mild degenerative disease were assigned to the control group and those with moderate/severe degenerative disease to the degenerative group. Spine radiographs were evaluated for degenerative disease by two radiologists working independently; discrepant evaluations were resolved by consensus. Lumbar spine and femoral neck bone mineral density was compared between the two groups. Forty-five (24%) of 186 women were assigned to the degenerative group and 141 (76%) to the control group. IN the degenerative group, mean bone mineral density measured 1.075g/cm? in the spine and 0.788g/cm2 in the femoral neck, while for controls the corresponding figures were 0.989g/cm2 and 0.765g/cm2. Adjusted for age, weight and height by means of analysis of variance, degenerative disease of the lumbar spine was a significant predictor of increased bone mineral density in the spine (p=0.0001) and femoral neck (p=0.0287). Our results indicate a positive relationship between degenerative disease of the lumbar spine and bone mineral density in the lumbar spine and femoral neck, and suggest that degenerative disease in that region, which leads to an intrinsic increase in bone mineral density in the femoral neck, may be a good negative predictor of osteoporotic hip fractures

2001-04-01

82

Roentgenological differential diagnosis in diseases of the sacroiliac joints  

International Nuclear Information System (INIS)

Conventional diagnostic radiology lends itself to the diagnosis of diseases of the sacroiliac joints and tomography in the dorsal position is useful in the identification of discrete changes. Processes of either an inflammatory or a degenerative etiology can be differentiated roentgenologically. Inflammatory disorders can be defined and differentiated to some extent radiomorphologically; this requires to analyse the dimension and temporal sequence of reaction forms of the sacroiliac joints - destruction, sklerosis, ankylosis. The 'colourful picture' is characteristic of morbus Bechterew; however, it is no exclusive proof since a number of other disorders cause similar changes. (orig.)

1985-01-01

83

Roentgenological differential diagnosis in diseases of the sacroiliac joints  

Energy Technology Data Exchange (ETDEWEB)

Conventional diagnostic radiology lends itself to the diagnosis of diseases of the sacroiliac joints and tomography in the dorsal position is useful in the identification of discrete changes. Processes of either an inflammatory or a degenerative etiology can be differentiated roentgenologically. Inflammatory disorders can be defined and differentiated to some extent radiomorphologically; this requires to analyse the dimension and temporal sequence of reaction forms of the sacroiliac joints - destruction, sklerosis, ankylosis. The 'colourful picture' is characteristic of morbus Bechterew; however, it is no exclusive proof since a number of other disorders cause similar changes.

Erlemann, R.; Peters, P.E.

1985-12-01

84

Radiology of chronic diseases of the ankle joint  

International Nuclear Information System (INIS)

The etiology of chronic diseases of the ankle joint comprises a wide spectrum including chronic inflammatory processes and chronic degenerative, tumorous and neuropathic processes, as well as some specific syndromes based on chronic changes of the ankle joint. Of the inflammatory processes, chronic juvenile arthritis (JVC) is the most common disease. However, also Reiter disease, psoriasis or chronic monoarthritid diseases such as gout, as well as granulomatous diseases (tuberculosis, sarcoidosis) and fungal infections, may affect the ankle joint in a chronic course. Chronic degenerative changes are usually secondary due to abnormal positioning of the joint constituents or repetitive trauma. Neuropathic changes, as frequently seen in the course of diabetes, present with massive osseous destruction and malposition of the articular constituents. Chronic osseous as well as cartilaginous and synovial changes are seen in hemoplici patients. Chronic traumatic changes are represented by pigmented villonodular synovitis (PVNS), and chondromatosis, both with a predilection for the ankle joint. Due to the possibilities of magnetic resonance imaging (MRI), diagnosis of chronic ankle changes includes chronic ligamentous, tendinous and soft tissue changes. With the use MRI, specific syndromes can be defined which particularly affect the ankle joint in a chronic way, such as the os trigonum syndrome, the anterolateral impingement syndrome and the sinus tarsi syndrome. Nevertheless, plain film radiographs are still the basic element of any investigation. MRI, however, can be potentially used as a second investigation, saving an unnecessary cascade of investigations with ultrasound and CT. The latter investigations are used only with very specific indications, for instance CT for subtle bone structures and sonography for a limited investigation of tendons or evaluation of fluid. Particularly due to the possibilities of MRI and the development of special gradient-echo imaging or high-resolution coils, the investigation of the ankle joint still offers a wide spectrum of innovation for the next years, which is particularly enforced by the increasing demand for specific diagnosis of chronic diseases in orthopedic medicine. (orig.)

1999-01-01

85

[Lower urinary tract dysfunction and degenerative brain disease].  

Science.gov (United States)

Although lower urinary tract dysfunction and dementia are classically associated, some patients with advanced dementia do not experience incontinence. Management of these patients must be based on careful assessment of the respective roles of ageing of the urinary tract and dementia in the pathogenesis of incontinence. It is also important to distinguish those dementia syndromes that are inevitably accompanied by urinary incontinence (such as normal pressure hydrocephalus) and those in which urinary incontinence is a late phenomenon (such as Alzheimer's disease). The diagnostic and therapeutic strategy must then be based on a stepwise approach, by eliminating all simple causes of lower urinary tract dysfunction and preferring the most conservative treatments possible. PMID:17622067

Robain, G; Chartier-Kastler, E; Ruffion, A

2007-05-01

86

Vitamin A Derivatives as Treatment Options for Retinal Degenerative Diseases  

Directory of Open Access Journals (Sweden)

Full Text Available The visual cycle is a sequential enzymatic reaction for vitamin A, all-trans-retinol, occurring in the outer layer of the human retina and is essential for the maintenance of vision. The central source of retinol is derived from dietary intake of both retinol and pro-vitamin A carotenoids. A series of enzymatic reactions, located in both the photoreceptor outer segment and the retinal pigment epithelium, transform retinol into the visual chromophore 11-cis-retinal, regenerating visual pigments. Retina specific proteins carry out the majority of the visual cycle, and any significant interruption in this sequence of reactions is capable of causing varying degrees of blindness. Among these important proteins are Lecithin:retinol acyltransferase (LRAT and retinal pigment epithelium-specific 65-kDa protein (RPE65 known to be responsible for esterification of retinol to all-trans-retinyl esters and isomerization of these esters to 11-cis-retinal, respectively. Deleterious mutations in these genes are identified in human retinal diseases that cause blindness, such as Leber congenital amaurosis (LCA and retinitis pigmentosa (RP. Herein, we discuss the pathology of 11-cis-retinal deficiency caused by these mutations in both animal disease models and human patients. We also review novel therapeutic strategies employing artificial visual chromophore 9-cis-retinoids which have been employed in clinical trials involving LCA patients.

Tadao Maeda

2013-07-01

87

Neurochemical imaging of Alzheimer's disease and other degenerative dementias  

International Nuclear Information System (INIS)

A wide variety of neurochemical and functional imaging approaches have been applied to the study of progressive dementias, particularly Alzheimer's disease (Ad) and related disorders. Despite considerable progress in the past decade, the cause((s) of most cases of Ad remain undetermined and preventive or protective therapies are lacking. Specifically-designed imaging procedures have permitted the testing of pathophysiological hypotheses of the etiology and progression of Ad, and have yielded important insights in several areas including the potential roles of cerebral cortical cholinergic lesions, cellular inflammation, and losses of cortical synapses. From the perspective of clinical diagnosis, PET glucose metabolism imaging with use of (18F)2-fluorodeoxyglucose (FDG) is the most sensitive and specific imaging modality yet identified. The overall performance of PET FDG is favorable for routine clinical evaluation of suspected Ad, and will likely gain increasing utilization in the near future. Assessments of glucose metabolism and other, specific aspects of neurochemistry in Ad will provide direct measures of therapeutic drug actions and may permit distinction of symptomatic versus disease-modifying therapies as they are developed and introduced in clinical trials

1998-09-01

88

Effects of chondroitin sulfate and sodium hyaluronate on chondrocytes and extracellular matrix of articular cartilage in dogs with degenerative joint disease / Efeitos do sulfato de condroitina e do hialuronato de sódio nos condrócitos e na matriz extracelular na cartilagem articular de cães com doença articular degenerativa  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Foram utilizadas amostras de cartilagem articular do fêmur, tíbia e patela de 15 cães com doença articular degenerativa (DAD), induzida experimentalmente. Foram constituídos três grupos de cinco animais: grupo 1 - controle, não medicado; grupo 2 - tratado com sulfato de condroitina e grupo 3 - trata [...] do com hialuronato de sódio. As amostras foram processadas e coradas pelas técnicas de HE e de azul de toluidina para avaliação das alterações morfológicas, e impregnadas pelo nitrato de prata para análise da atividade metabólica e/ou proliferativa dos condrócitos, por meio da visualização e quantificação de regiões organizadoras do nucléolo (NORs). Não foram notadas diferenças significativas (P0,05) na contagem de NORs, células e NORs/célula entre os grupos. As maiores contagens de NORs e de células no grupo tratado com hialuronato de sódio sugeriram aumento da taxa de proliferação dos condrócitos. A maior relação de NORs/célula obtida no grupo tratado com sulfato de condroitina sugere que essa droga estimula a atividade metabólica do condrócito, minimizando as lesões ocorridas durante a DAD. Abstract in english Samples of articular cartilage of femur, tibia and patella of 15 dogs with experimentally induced degenerative joint disease (DJD) were microscopically analyzed. Animals were distributed into three groups (n=5): the control group received no medication; the second group was treated with chondroitin [...] sulfate and the third received sodium hyaluronate. Samples were processed and stained with HE and toluidine blue for morphological evaluation. The metabolic and proliferative activity of the chondrocytes was evaluated by the measurement of nucleolar organizer regions (NORs) after impregnation by silver nitrate. Significant differences were not observed (P>0.05) in the morphology among the groups, however, the group treated with sodium hyaluronate had a higher score suggesting a trend to a greater severity of the lesions. Significant differences were not observed (P>0.05) in the measurement of NORs, cells and NORs/cells among the groups. Although differences were not significant, sodium hyaluronate group showed higher NOR and cell counts which suggested an increase of the proliferation rate of chondrocytes. In addition, a higher NOR/cell ratio in the group treated with chondroitin sulfate suggested that this drug may have stimulated the metabolic activity of the chondrocytes, minimizing the lesions resulting from DJD.

G., Gonçalves; E.G., Melo; M.G., Gomes; V.A., Nunes; C.M.F., Rezende.

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Effects of chondroitin sulfate and sodium hyaluronate on chondrocytes and extracellular matrix of articular cartilage in dogs with degenerative joint disease Efeitos do sulfato de condroitina e do hialuronato de sódio nos condrócitos e na matriz extracelular na cartilagem articular de cães com doença articular degenerativa  

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Full Text Available Samples of articular cartilage of femur, tibia and patella of 15 dogs with experimentally induced degenerative joint disease (DJD were microscopically analyzed. Animals were distributed into three groups (n=5: the control group received no medication; the second group was treated with chondroitin sulfate and the third received sodium hyaluronate. Samples were processed and stained with HE and toluidine blue for morphological evaluation. The metabolic and proliferative activity of the chondrocytes was evaluated by the measurement of nucleolar organizer regions (NORs after impregnation by silver nitrate. Significant differences were not observed (P>0.05 in the morphology among the groups, however, the group treated with sodium hyaluronate had a higher score suggesting a trend to a greater severity of the lesions. Significant differences were not observed (P>0.05 in the measurement of NORs, cells and NORs/cells among the groups. Although differences were not significant, sodium hyaluronate group showed higher NOR and cell counts which suggested an increase of the proliferation rate of chondrocytes. In addition, a higher NOR/cell ratio in the group treated with chondroitin sulfate suggested that this drug may have stimulated the metabolic activity of the chondrocytes, minimizing the lesions resulting from DJD.Foram utilizadas amostras de cartilagem articular do fêmur, tíbia e patela de 15 cães com doença articular degenerativa (DAD, induzida experimentalmente. Foram constituídos três grupos de cinco animais: grupo 1 - controle, não medicado; grupo 2 - tratado com sulfato de condroitina e grupo 3 - tratado com hialuronato de sódio. As amostras foram processadas e coradas pelas técnicas de HE e de azul de toluidina para avaliação das alterações morfológicas, e impregnadas pelo nitrato de prata para análise da atividade metabólica e/ou proliferativa dos condrócitos, por meio da visualização e quantificação de regiões organizadoras do nucléolo (NORs. Não foram notadas diferenças significativas (P0,05 na contagem de NORs, células e NORs/célula entre os grupos. As maiores contagens de NORs e de células no grupo tratado com hialuronato de sódio sugeriram aumento da taxa de proliferação dos condrócitos. A maior relação de NORs/célula obtida no grupo tratado com sulfato de condroitina sugere que essa droga estimula a atividade metabólica do condrócito, minimizando as lesões ocorridas durante a DAD.

G. Gonçalves

2008-02-01

90

Trophic factors in the pathogenesis and therapy for retinal degenerative diseases.  

Science.gov (United States)

Trophic factors are endogenously secreted proteins that act in an autocrine and/or paracrine fashion to affect vital cellular processes such as proliferation, differentiation, and regeneration, thereby maintaining overall cell homeostasis. In the eye, the major contributors of these molecules are the retinal pigment epithelial (RPE) and Müller cells. The primary paracrine targets of these secreted proteins include the photoreceptors and choriocapillaris. Retinal degenerative diseases such as age-related macular degeneration and retinitis pigmentosa are characterized by aberrant function and/or eventual death of RPE cells, photoreceptors, choriocapillaris, and other retinal cells. We discuss results of in vitro and in vivo animal studies in which candidate trophic factors, either singly or in combination, were used in an attempt to ameliorate photoreceptor and/or retinal degeneration. We also examine current trophic factor therapies as they relate to the treatment of retinal degenerative diseases in clinical studies. PMID:24417953

Kolomeyer, Anton M; Zarbin, Marco A

2014-01-01

91

Oxygen-ozone therapy for degenerative spine disease in the elderly: a prospective study.  

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We describe our experience of oxygen-ozone therapy to treat degenerative spine disease in the elderly. From April 2004 to March 2008 we selected 129 patients with CT and/or MR evidence of spondyloarthrosis and disc degeneration of the lumbar spine. All patients enrolled in the study had contraindications to the administration of commonly used analgesic and anti-inflammatory drugs.Oxygen-ozone therapy was given by CT-guided intraforaminal injection as the first treatment followed by 4 weekly paralumbar infiltrations on an outpatient basis. The full treatment lasted a month. Clinical outcome was assessed 3 months and 1 year after treatment. The good results obtained indicate that oxygen-ozone therapy is an ideal treatment with no side-effects in elderly patients with degenerative spine disease. PMID:21107950

Bonetti, Matteo; Fontana, Alessandro; Martinelli, Francesco; Andreula, Cosma

2011-01-01

92

C5 palsy following anterior decompression and spinal fusion for cervical degenerative diseases  

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Postoperative C5 palsy is a common complication after cervical spine decompression surgery. However, the incidence, prognosis, and etiology of C5 palsy after anterior decompression with spinal fusion (ASF) have not yet been fully established. In the present study, we analyzed the clinical and radiological characteristics of patients who developed C5 palsy after ASF for cervical degenerative diseases. The cases of 199 consecutive patients who underwent ASF were analyzed to clarify the incidenc...

Hashimoto, Mitsuhiro; Mochizuki, Macondo; Aiba, Atsuomi; Okawa, Akihiko; Hayashi, Koichi; Sakuma, Tsuyoshi; Takahashi, Hiroshi; Koda, Masao; Takahashi, Kazuhisa; Yamazaki, Masashi

2010-01-01

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Allelic variation in the vitamin D receptor, lifestyle factors and lumbar spinal degenerative disease  

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OBJECTIVE—To describe the relation between spinal degenerative disease, allelic variation in the vitamin D receptor gene, and lifestyle factors in a population-based association study.?METHODS—Random population-based sample of 110 men and 172 women over 60 years of age participating in the Dubbo Osteoporosis Epidemiology Study who had spinal radiographs (performed according to a standardised approach), assessment of lifestyle factors, bone densitometry as well as blood taken for ...

1998-01-01

94

Is there a role for wine in cancer and the degenerative diseases of aging?  

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Creina S StockleyThe Australian Wine Research Institute, Adelaide, South Australia, AustraliaAbstract: Population aging is associated with the increased incidence cancer and of degenerative diseases. Population aging is occurring on a global scale, with faster aging projected for the coming decades than has occurred in the past. Globally, the population aged 60 years and over is projected to nearly triple by 2050, while the population aged 80 years and over is projected to experience a more t...

2009-01-01

95

Analysis of crucial molecules involved in herniated discs and degenerative disc disease  

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OBJECTIVES: Herniated discs and degenerative disc disease are major health problems worldwide. However, their pathogenesis remains obscure. This study aimed to explore the molecular mechanisms of these ailments and to identify underlying therapeutic targets. MATERIAL AND METHODS: Using the GSE23130 microarray datasets downloaded from the Gene Expression Omnibus database, differentially co-expressed genes and links were identified using the differentially co-expressed gene and link method with...

Zhigang Qu; Weiwei Miao; Qi Zhang; Zhenyu Wang; Changfeng Fu; Jinhua Han; Yi Liu

2013-01-01

96

Functional magnetic resonance imaging. Application to degenerative brain disease and hydrocephalus.  

Science.gov (United States)

Magnetic resonance (MR) imaging, in addition to its excellent depiction of neuroanatomy, is being developed as a major technique for functional imaging of cerebrospinal fluid motion and for measurement of velocity, strain, and diffusional processes within the brain parenchyma. Functional MR imaging studies are revealing basic physiology of blood flow interactions with CSF motion and dynamic processes of brain parenchyma. Normal pressure hydrocephalus and degenerative brain disease are current focuses of functional MR imaging studies. PMID:7743080

Feinberg, D A

1995-02-01

97

Is there a role for wine in cancer and the degenerative diseases of aging?  

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Full Text Available Creina S StockleyThe Australian Wine Research Institute, Adelaide, South Australia, AustraliaAbstract: Population aging is associated with the increased incidence cancer and of degenerative diseases. Population aging is occurring on a global scale, with faster aging projected for the coming decades than has occurred in the past. Globally, the population aged 60 years and over is projected to nearly triple by 2050, while the population aged 80 years and over is projected to experience a more than fivefold increase. Increased numbers of older individuals may have implications for associated expenditure on income support, housing and health services, although a healthy, independent older population can also form a valued social resource, for example in providing care for others, sharing skills and knowledge, and engaging in volunteer activities. Simple dietary measures such as moderate wine consumption to supplement a healthy exercise and nutrition routine, or as an adjunct to prescription medicines when appropriate, are thus needed to maintain an aging population. The role of wine in cancer and the degenerative diseases of aging is thus discussed.Keywords: population aging, wine, degenerative disease, cancer

Creina S Stockley

2009-06-01

98

Degenerative osteoarthritis of atlanto-odontoid joint: CT findings and clinical analysis  

International Nuclear Information System (INIS)

Purpose: To analyze the CT appearances and clinical aspects of the degeneration at atlanto-odontoid(A-O) joint. Methods: Thin section axial CT scans, of AO joints were studied in 317 consecutive patients who underwent brain or cervical spine CT examinations. The images were viewed using double-blind method. Observation included: osteophytosis, changes of joint space and transverse ligament, and the clinical symptoms as well. Results: CT findings of AO joint degeneration included: formation of osteophyte, narrowing of joint space, transverse ligament calcification, and joint vacuum phenomenon. Among individuals above 40 years of age, the incidence of degeneration at AO joint went up gradually (P<0.01). Conclusion: Degeneration of AO joint was not uncommon among aged people, CT could better demonstrate the pathological changes

1998-07-01

99

Differentiation of malignant and degenerative benign bone disease using 99mTc-citrate scintigraphy  

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Objective: To differentiate malignant and degenerative benign bone disease using 99mTc- citrate scintigraphy. Methods: Thirty-nine patients (92 lesions) with confirmed malignant bone disease or degenerative benign bone disease were studied, for which the results of 99mTe-methylene diphosphonate(99mTc- MDP) scintigraphy were positive. 99mTc-citrate scintigraphy was performed within a time interval of 2-7 days after 99mTc-MDP scintigraphy. Visual analysis and semiquantitative analysis were applied. Each lesion was scored as malignant or benign, which was independently verified, using conventional techniques (histopathology, X-ray, CT, MRI and clinical follow up). Results: In visual analysis of 99mTc-citrate imaging, most malignant lesions (35/48, 72.92%) clearly showed high radioactivity accumulation, while most benign lesions (39/44, 88.64%) had not obviously visible uptake of 99mTc-citrate. In semiquantitative analysis of 99mTc- citrate image, malignant lesions demonstrated a higher lesion-to-background radioisotope uptake ratio (RUR) than that of benign degenerative lesions (1.47 ± 0.42 vs. 1.09 ± 0.38, t=2.887, P99mTc-MDP in the two groups is of the same (1.96 ± 0.25 vs. 1.87 ± 0.21, t=1.178, P>0.20). Conclusion: 99mTc- citrate scintigraphy is a promising method to differentiate malignant from benign degenerative lesions seen as areas of increased activity on 99mTc-MDP bone scintigraphy. (authors)

2008-05-01

100

Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation.  

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Autophagy is a cell protective mechanism for maintaining cellular homeostasis. The present study aimed to investigate whether autophagy is enhanced in the biomechanically induced degenerative cartilage of the temporomandibular joint (TMJ) and the potential role of mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) and mammalian Target of rapamycin (mTOR) in this observation. To induce degenerative changes in the TMJs, rats were subjected to biomechanical dental stimulation by moving 4 molars away from their original position as we previously reported. The ultrastructure of autophagosome was observed by transmission electron microscopy. The number of lysosomes was analyzed by flow cytometry. The expression levels of Beclin1 and LC3 and the involvement of MAP4K3 activity were detected by immunohistochemistry, real-time PCR and western blot. The activity of the mTOR pathway indicated by p-mTOR and p-p70S6 K was assayed by western blot. TMJ degeneration, characterized by irregular cell arrangement and cell-free area, was induced in the experimental groups. Under transmission electron microscopy, we observed the presence of autophagosomes, small patches of condensed chromatin, abundant rough endoplasmic reticulum and Golgi apparatus. The number of lysosomes and the expression levels of Beclin1 and LC3 increased, while the activity of mTOR and the expression level of MAP4K3 decreased in the experimental groups. Cartilage in TMJ which was induced to be degenerative biomechanically exhibited autophagy accompanied by reduced mTOR and MAP4K3 activity. PMID:23386193

Zhang, Mian; Zhang, Jing; Lu, Lei; Qiu, Zhong-Ying; Zhang, Xu; Yu, Shi-Bin; Wu, Yao-Ping; Wang, Mei-Qing

2013-04-01

 
 
 
 
101

Analysis of crucial molecules involved in herniated discs and degenerative disc disease  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english OBJECTIVES: Herniated discs and degenerative disc disease are major health problems worldwide. However, their pathogenesis remains obscure. This study aimed to explore the molecular mechanisms of these ailments and to identify underlying therapeutic targets. MATERIAL AND METHODS: Using the GSE23130 [...] microarray datasets downloaded from the Gene Expression Omnibus database, differentially co-expressed genes and links were identified using the differentially co-expressed gene and link method with a false discovery rate ,0.25 as a significant threshold. Subsequently, the underlying molecular mechanisms of the differential co-expression of these genes were investigated using Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. In addition, the transcriptional regulatory relationship was also investigated. RESULTS: Through the analysis of the gene expression profiles of different specimens from patients with these diseases, 539 differentially co-expressed genes were identified for these ailments. The ten most significant signaling pathways involving the differentially co-expressed genes were identified by enrichment analysis. Among these pathways, apoptosis and extracellular matrix-receptor interaction pathways have been reported to be related to these diseases. A total of 62 pairs of regulatory relationships between transcription factors and their target genes were identified as critical for the pathogenesis of these diseases. CONCLUSION: The results of our study will help to identify the mechanisms responsible for herniated discs and degenerative disc disease and provides a theoretical basis for further therapeutic study.

Zhigang, Qu; Weiwei, Miao; Qi, Zhang; Zhenyu, Wang; Changfeng, Fu; Jinhua, Han; Yi, Liu.

102

Analysis of crucial molecules involved in herniated discs and degenerative disc disease  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVES: Herniated discs and degenerative disc disease are major health problems worldwide. However, their pathogenesis remains obscure. This study aimed to explore the molecular mechanisms of these ailments and to identify underlying therapeutic targets. MATERIAL AND METHODS: Using the GSE23130 microarray datasets downloaded from the Gene Expression Omnibus database, differentially co-expressed genes and links were identified using the differentially co-expressed gene and link method with a false discovery rate ,0.25 as a significant threshold. Subsequently, the underlying molecular mechanisms of the differential co-expression of these genes were investigated using Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. In addition, the transcriptional regulatory relationship was also investigated. RESULTS: Through the analysis of the gene expression profiles of different specimens from patients with these diseases, 539 differentially co-expressed genes were identified for these ailments. The ten most significant signaling pathways involving the differentially co-expressed genes were identified by enrichment analysis. Among these pathways, apoptosis and extracellular matrix-receptor interaction pathways have been reported to be related to these diseases. A total of 62 pairs of regulatory relationships between transcription factors and their target genes were identified as critical for the pathogenesis of these diseases. CONCLUSION: The results of our study will help to identify the mechanisms responsible for herniated discs and degenerative disc disease and provides a theoretical basis for further therapeutic study.

Zhigang Qu

2013-01-01

103

MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints  

International Nuclear Information System (INIS)

Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab

1996-07-01

104

Spinal facet joint biomechanics and mechanotransduction in normal, injury and degenerative conditions.  

Science.gov (United States)

The facet joint is a crucial anatomic region of the spine owing to its biomechanical role in facilitating articulation of the vertebrae of the spinal column. It is a diarthrodial joint with opposing articular cartilage surfaces that provide a low friction environment and a ligamentous capsule that encloses the joint space. Together with the disc, the bilateral facet joints transfer loads and guide and constrain motions in the spine due to their geometry and mechanical function. Although a great deal of research has focused on defining the biomechanics of the spine and the form and function of the disc, the facet joint has only recently become the focus of experimental, computational and clinical studies. This mechanical behavior ensures the normal health and function of the spine during physiologic loading but can also lead to its dysfunction when the tissues of the facet joint are altered either by injury, degeneration or as a result of surgical modification of the spine. The anatomical, biomechanical and physiological characteristics of the facet joints in the cervical and lumbar spines have become the focus of increased attention recently with the advent of surgical procedures of the spine, such as disc repair and replacement, which may impact facet responses. Accordingly, this review summarizes the relevant anatomy and biomechanics of the facet joint and the individual tissues that comprise it. In order to better understand the physiological implications of tissue loading in all conditions, a review of mechanotransduction pathways in the cartilage, ligament and bone is also presented ranging from the tissue-level scale to cellular modifications. With this context, experimental studies are summarized as they relate to the most common modifications that alter the biomechanics and health of the spine-injury and degeneration. In addition, many computational and finite element models have been developed that enable more-detailed and specific investigations of the facet joint and its tissues than are provided by experimental approaches and also that expand their utility for the field of biomechanics. These are also reviewed to provide a more complete summary of the current knowledge of facet joint mechanics. Overall, the goal of this review is to present a comprehensive review of the breadth and depth of knowledge regarding the mechanical and adaptive responses of the facet joint and its tissues across a variety of relevant size scales. PMID:21823749

Jaumard, Nicolas V; Welch, William C; Winkelstein, Beth A

2011-07-01

105

Degenerative periodontal-diseases and oral osteonecrosis: The role of gene-environment interactions  

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Chronic-degenerative dentistry diseases, including periodontal diseases and oral osteonecrosis, are widespread in human populations and represent a significant problem for public health. These diseases result from pathogenic mechanisms created by the interaction between environmental genotoxic risk-factors and genetic assets conferring individual susceptibility. Osteonecrosis occurs in subjects undergoing exposure to high doses of DNA-damaging agents for chemo- and radiotherapy of neoplastic diseases. In susceptible patients, ionizing radiation and biphosphonate-chemotherapy induce severe, progressive, and irreversible degeneration of facial bones, resulting in avascular necrosis of the jaw. This may also occur in patients receiving biphosphonate for osteoporosis therapy. Periodontal diseases include chronic, aggressive, and necrotizing periodontitis, often resulting in severe alteration of periodontal tissues and tooth loss. Cigarette smoking and chronic inflammation caused by specific bacteria are the main risk factors for periodontitis. Oxidative damage plays a fundamental pathogenic role, as established by detection of mitochondrial DNA damage in the gingival tissue of patients with periodontitis. Endogenous risk factors in dental diseases include polymorphisms for metabolic enzymes such as glutathione transferases M1 and T1, N-acetyl transferase 2, and CYP 1A1. Other genetic polymorphisms that confer susceptibility to dentistry diseases affect genes encoding metalloproteases (involved in periodontal tissue remodeling and degradation), cytokines (involved in inflammation), prothrombin, and DNA repair activities. These findings provide evidence that dentistry diseases are related to risk factors associated with environmental mutagenesis. This issue warrants future investigations aimed at improving oral health and preventing oral degenerative diseases using molecular and experimental approaches currently utilized in mutagenicity studies.

Baldi, D. [Department of Medical, Biophysical, and Dentistry Sciences and Technologies, University of Genoa (Italy); Izzotti, A. [Department of Health Sciences, University of Genoa, Via A. Pastore 1 (Italy); Bonica, P.; Pera, P. [Department of Medical, Biophysical, and Dentistry Sciences and Technologies, University of Genoa (Italy); Pulliero, A., E-mail: alessandra.pulliero@unige.it [Department of Health Sciences, University of Genoa, Via A. Pastore 1 (Italy)

2009-07-10

106

Surgical Management of Temporomandibular Joint Ankylosis in Ankylosing Spondylitis  

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Relatively few patients develop such severe degenerative temporomandibular joint (TMJ) disease that they require total joint replacement. Current indications include those conditions involving condylar bone loss such as degenerative (osteoarthritis) or inflammatory joint disease (ankylosing spondylitis, rheumatoid, and psoriatic). Ankylosis of the temporomandibular joint (TMJ) secondary to ankylosing spondylitis remains an under investigated entity. We aim to provide an overview of treatment ...

2011-01-01

107

Operative Outcomes for Cervical Degenerative Disease: A Review of the Literature  

Science.gov (United States)

To date, several studies were conducted to find which procedure is superior to the others for the treatment of cervical myelopathy. The goal of surgical treatment should be to decompress the nerves, restore the alignment of the vertebrae, and stabilize the spine. Consequently, the treatment of cervical degenerative disease can be divided into decompression of the nerves alone, fixation of the cervical spine alone, or a combination of both. Posterior approaches have historically been considered safe and direct methods for cervical multisegment stenosis and lordotic cervical alignment. On the other hand, anterior approaches are indicated to the patients with cervical compression with anterior factors, relatively short-segment stenosis, and kyphotic cervical alignment. Recently, posterior approach is widely applied to several cervical degenerative diseases due to the development of various instruments. Even if it were posterior approach or anterior approach, each would have its complication. There is no Class I or II evidence to suggest that laminoplasty is superior to other techniques for decompression. However, Class III evidence has shown equivalency in functional improvement between laminoplasty, anterior cervical fusion, and laminectomy with arthrodesis. Nowadays, each surgeon tends to choose each method by evaluating patients' clinical conditions.

Nishizawa, Kazuya; Mori, Kanji; Saruhashi, Yasuo; Matsusue, Yoshitaka

2012-01-01

108

Compounded pimobendan for canine chronic degenerative mitral valve disease and pulmonary hypertension.  

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Pimobendan (Vetmedin) is an effective treatment for canine chronic degenerative mitral valve disease and dilated cardiomyopathy. In an off-label use, it may also be of benefit for the treatment of pulmonary hypertension in dogs. In this report, we describe the effects of a palatable customized oral form of pimobendan used with both compounded and commercially manufactured conventional drug therapy to treat degenerative mitral valve disease and pulmonary hypertension in two small dogs. For those patients, who resisted many types of oral medication, the standard manufactured dose of pimobendan was inappropriate. Formulations of the preparations used to treat the patients described in this report are provided for easy reference. It should be noted that at the time of this writing, Boehringer Ingelheim GmbH (Ingelheim am Rhein, Germany), the manufacturer of pimobendan, has expressed concern about the stability of that agent in aqueous compounded form. To our knowledge, no current data confirming the stability or bioequivalence of compounded pimobendan exist. PMID:23050309

Helms, Scott R; Fox, Samantha; Mixon, William; Vail, Jane

2012-01-01

109

Joint Modeling of Disease Pairs  

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Full Text Available Aim: Exploring the spatial patterns in joint distribution of incidences of two diseases. Material and method: A Poisson-Binomial regression model was used in analysing hospitalisation counts data in Hungary, 2008. Model parameters were estimated by MCMC implemented in WinBUGS. Results: Spatial patterns of laryngeal and hypopharyngeal cancer differ significantly from that of their ratio. Conclusion: The Poisson-Binomial model proposed here might help clarify us the different spatial dependencies of the sum and the ratio of incidences of two diseases.

Gergely TÓTH

2012-03-01

110

Histochemical and magnetic resonance imaging study of degenerative diseases in human intervertebral discs  

International Nuclear Information System (INIS)

The aim of this study was to compare degenerative changes by means of histochemical study (with nicotinamide adenine dinucleotide phosphate diaphorase - NADPH-d) and magnetic resonance imaging (MRI) findings of degenerated human intervertebral disc (IVD). We used surgical specimens from patients undergoing surgical treatment in the lumbar region and fresh cadaveric lumbar spines for histochemical study and MRI examination of patients with low back pain. The rate of IVD degeneration depends on age, weight, abnormal mechanical load, genetics, trauma, inflammation and others. All structures from IVD (nucleus pulposus, annulus fibrosus, cartilage end plate) and the vertebral body were assessed. The histochemical study showed an increase in the intensity of NADPH-d reaction in the cells, parallel to the increase in the degree of IVD degeneration. Degenerative diseases of IVD showed different MRI findings related to the decrease in the water content of IVD, protrusion, extrusion, stenosis of vertebral canal, osteochondrosis, osteophits of the vertebral body, ossification and hypertrophy of longitudinal ligaments, Modic I and II changes and compression of the dural sac. The correlation between the histochemical results and MRI findings depended basically on aging

2012-01-01

111

Neurophysiological evaluation of patients with degenerative diseases of the cervical spine  

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Full Text Available Bacground/Aim. Diagnostic protocol for patients with degenerative diseases of the cervical spine demands, in parallel with neuroimaging methods, functional evaluation through neurophysiological methods (somatosensitive and motor evoked potentials and electromyoneurography aiming to evaluate possible subclinical affection of spinal medula resulting in neurological signs of long tract abnormalities. Considering diversities of clinical outcomes for these patients, complex diagnostic evaluation provides a prognosis of the disease progression. Methods. The study included 21 patients (48.24 ± 11.01 years of age with clinical presentation of cervical spondylarthropathy, without neuroradiological signs of myelopathy. For each patient, in addition to conventional neurophysiological tests (somatisensory evoked potentials - SSEP, motor evoked potentials - MEP, electromyoneurography - EMG, nerve conduction studies, we calculated central motor conduction time (CMCTF, as well the same parameter in relation to a different position of the head (maximal anteflexion and retroflexion, so-called dynamic tests. Results. Abnormalities of the peripheral motor neurone by conventional EMNeG was established in 2/3 of the patients, correponding to the findings of root condution time. Prolonged conventional CVMPF were found in 29% of the patients, comparing to 43% CVMPF abnormalities found with the dynamic tests. In addition, the SSEP findings were abnormal in 38% of the patients with degenerative diseases of the cervical spine. Conclusion. An extended neurophysiological protocol of testing corticospinal functions, including dynamic tests of central and periheral motor neurons are relevant for detection of subclinical forms of cervical spondylothic myelopathy, even at early stages. In addition to the conventional neurophysiological tests, we found usefull to include the dynamic motor tests and root conduction time measurement in diagnostic evaluation.

Ili? Tihomir V.

2011-01-01

112

Proximal Vertebral Body Fracture after 4-Level Fusion Using L1 as the Upper Instrumented Vertebra for Lumbar Degenerative Disease: Report of 2 Cases with Literature Review  

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Some cases with lumbar degenerative diseases require multi-level fusion surgeries. At our institute, 27 and 4 procedures of 3- and 4-level fusion were performed out of a total 672 posterior lumbar interfusions (PLIFs) on patients with lumbar degenerative disease from 2005 to 2010. We present 2 osteoporotic patients who developed proximal vertebral body fracture after 4-level fusion. Both cases presented with gait disability for leg pain by degenerative lumbar scoliosis and canal stenosis at t...

Yasuhara, Takao; Takahashi, Yuichi; Kumamoto, Shinji; Nakahara, Masayuki; Yoneda, Kotaro; Niimura, Tatsuomi; Tanoue, Takashi; Kusumegi, Akira; Sennari, Takashi; Hijikata, Yasukazu; Manabe, Hiroaki; Miyoshi, Yasuyuki; Date, Isao; Ogawa, Koichi; Nishida, Kenki

2013-01-01

113

When dialogue fails. Music therapy with elderly with neurological degenerative diseases  

DEFF Research Database (Denmark)

When dialogue fails. Music therapy with elderly with neurological degenerative diseases. In persons suffering from neurological degenerative diseases we often see the following symptoms: difficulties in remembering, concentrating, perceiving input, and controlling and timing movements. Normal every day conversation is building on abilities to remember facts or episodes, to sustain attention, to listen, and to time a response. Without these fundamental cognitive abilities it is difficult to communicate with others â?? unless the communication is adjusted to the person. Clients with a neurological degenerative disease like e.g. dementia are often socially isolated because of their failing abilities to communicate. Even if they live in a facility and are surrounded by care staff and peer residents, they might experience the environment as chaotic and the people as non-comprehensible. A missing meaningful interaction with others means that psychosocial needs are not met, and this leads to secondary symptoms of the neurological degeneration. Secondary symptoms might be expressed as repetitive behaviour, catastrophic reactions and situationally inappropriate behaviour. In a music therapeutical setting it is possible to adjust the communication in order to enter dialogue. The dialogue is the potential for sharing emotions and meeting psychosocial needs. The core of the music therapy is seen as the moments where interaction and dialogue occurs. But these moments are only â??highlightsâ? of the sessions, and before they can happen, the music therapist must build up a structure for the therapy that compensates for missing cognitive abilities of the client. This is illustrated by the following steps that integrate neuropsychological and psychodynamic theories: 1. Focus attention 2. Regulate arousal level 3. Dialogue 4. Conclusion 1. In order to compensate for missing short-term memory it is important to work deliberately with cuing. A specific song in the beginning of the music therapy session will e.g. signalise that the music therapy is to start. Using songs as cues activates cortical memory function, and work as memory traces in the brain. Using the same â??hello-songâ? in the beginning of a session - session after session - gives stability. Stability is constancy and familiarity of cues over time (Roberts & Algase 1988), and even people with severe memory deficits are capable of creating new memory traces and of learning the meaning of new cues. The first step in music therapy is to focus attention, e.g. with stability and cues, and the next step is to regulate arousal level towards environmental attention. 2. Environmental attention depends on levels of arousal. There is a relation between medium arousal levels and the ability to understand â??what is going onâ??. â??You need to have just the right level of activation to perform optimallyâ? (LeDoux 1998, p. 289). Stimulating and sedating effects of music or songs are obtained by musical parameters, such as tempo, rhythm, timbre, volume, pitch, phrasing, dynamic, and timing. By communicative parameters such as proximity, touch, movements, rhythmic rocking or â??dancingâ?, the music therapist can apply his/her presence to stimulate or calm down the person. Altogether these techniques are inherent in our communicative musicality (Trevarthen 1999). 3. On some occasions the therapist needs many sessions in order to build up a structure and bring the person to a moderate arousal level, where the conditions for interacting and entering dialogue are at their optimum. When these conditions are created it is possible to meet psychosocial needs and decrease secondary symptoms of the degenerative disease. At this level the therapist might work with psychotherapeutic strategies such as validation, holding and facilitation (Kitwood 1997). 4. By marking and cuing the end of the session stability is established. A timeframe is given, and the client can trust that more sessions will follow in spite of the separation. Ending a music therapy session with a sp

Ridder, Hanne Mette Ochsner

2004-01-01

114

Predictive diagnostics and personalized medicine for the prevention of chronic degenerative diseases  

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Full Text Available Abstract Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD such as cancer, cardiovascular, autoimmune or neurodegenerative diseases among the elderly. CDD are of complex diagnosis, difficult to treat and absorbing an increasing proportion in the health care budgets worldwide. However, recent development in modern medicine especially in genetics, proteomics, and informatics is leading to the discovery of biomarkers associated with different CDD that can be used as indicator of disease’s risk in healthy subjects. Therefore, predictive medicine is merging and medical doctors may for the first time anticipate the deleterious effect of CDD and use markers to identify persons with high risk of developing a given CDD before the clinical manifestation of the diseases. This innovative approach may offer substantial advantages, since the promise of personalized medicine is to preserve individual health in people with high risk by starting early treatment or prevention protocols. The pathway is now open, however the road to an effective personalized medicine is still long, several (diagnostic predictive instruments for different CDD are under development, some ethical issues have to be solved. Operative proposals for the heath care systems are now needed to verify potential benefits of predictive medicine in the clinical practice. In fact, predictive diagnostics, personalized medicine and personalized therapy have the potential of changing classical approaches of modern medicine to CDD.

Caruso Calogero

2010-12-01

115

Imbalanced Protein Expression Patterns of Anabolic, Catabolic, Anti-Catabolic and Inflammatory Cytokines in Degenerative Cervical Disc Cells: New Indications for Gene Therapeutic Treatments of Cervical Disc Diseases  

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Degenerative disc disease (DDD) of the cervical spine is common after middle age and can cause loss of disc height with painful nerve impingement, bone and joint inflammation. Despite the clinical importance of these problems, in current publications the pathology of cervical disc degeneration has been studied merely from a morphologic view point using magnetic resonance imaging (MRI), without addressing the issue of biological treatment approaches. So far a wide range of endogenously expressed bioactive factors in degenerative cervical disc cells has not yet been investigated, despite its importance for gene therapeutic approaches. Although degenerative lumbar disc cells have been targeted by different biological treatment approaches, the quantities of disc cells and the concentrations of gene therapeutic factors used in animal models differ extremely. These indicate lack of experimentally acquired data regarding disc cell proliferation and levels of target proteins. Therefore, we analysed proliferation and endogenous expression levels of anabolic, catabolic, ant-catabolic, inflammatory cytokines and matrix proteins of degenerative cervical disc cells in three-dimensional cultures. Preoperative MRI grading of cervical discs was used, then grade III and IV nucleus pulposus (NP) tissues were isolated from 15 patients, operated due to cervical disc herniation. NP cells were cultured for four weeks with low-glucose in collagen I scaffold. Their proliferation rates were analysed using 3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide. Their protein expression levels of 28 therapeutic targets were analysed using enzyme-linked immunosorbent assay. During progressive grades of degeneration NP cell proliferation rates were similar. Significantly decreased aggrecan and collagen II expressions (P<0.0001) were accompanied by accumulations of selective catabolic and inflammatory cytokines (disintegrin and metalloproteinase with thrombospondin motifs 4 and 5, matrix metalloproteinase 3, interleukin-1?, interleukin-1 receptor) combined with low expression of anti-catabolic factor (metalloproteinase inhibitor 3) (P<0.0001). This study might contribute to inhibit inflammatory catabolism of cervical discs.

Mern, Demissew S.; Beierfu?, Anja; Fontana, Johann; Thome, Claudius; Hegewald, Aldemar A.

2014-01-01

116

Spontaneous degenerative polioencephalomyelopathy in feeder pigs--a new motor neuron disease?  

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A central nervous disorder occurred spontaneously in a herd of feeder pigs characterized by muscle fasciculations, convulsions, squealing, and acute death in numerous animals. Histopathology revealed a degenerative poliomyeloencephalopathy of brain stem and spinal cord consisting of neuronal hypertrophy, chromatolysis, neuronophagia, and satellitosis associated with Wallerian degeneration of ventral rootlets and neurogenic muscle atrophy of limb musculature. The sudden onset of clinical signs and the pattern of morphological findings were suggestive of intoxication. Though parathion was found in two animals, serum acetylcholine esterase activity and morphological findings were not compatible with an organophosphate poisoning. A hereditary disorder was excluded by genetic analysis. Summarized findings in the present cases are reminiscent of changes observed in ruminants suffering from patulin poisoning, a neuromycotoxicosis caused by Aspergillus clavatus. However, toxicological and microbiological investigations failed to identify the cause of this unusual and so far not described disease in pigs. Morphologically, lesion distribution and alterations of motor neurons resemble changes observed in equine motor neuron disease, spinal muscular atrophy of certain canine breeds, and amyotrophic lateral sclerosis (Lou Gehrig's disease) in man. Therefore, the term spontaneous porcine motor neuron disease (SPMND) is proposed for this new and unique entitiy. PMID:23227771

Wohlsein, Peter; Brügmann, Michael; Pfeiffer, Ina; Ammer, Hermann; Wolf, Petra; Baumgartner, Wolfgang; Peters, Martin

2012-01-01

117

Adult degenerative and senile degenerative hyperostosis triangularis ilii  

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A randomised study of 2000 patients (1000 males, 1000 females) revealed two forms of the triangular hyperostosis of the ilium in female patients. The hyperostosis triangularis ilii, HTI, is also known as osteitis condensans. One form of HTI concerning women under the age of 50 is called the adult generative HTI, the other beyond the age of 50 senile degenerative HTI. These two forms are not evident in male patients. The 3.05% incidence of HTI in adults appeared to be higher than presumed till now. The sex incidence male/female of 1:1.6 diverges considerably from preceding investigations. Histomorphological studies of two autopsies of cases of senile degenerative HTI revealed no signs of inflammation. Statistical correlations of HTI with other chronic diseases of the pelvis and hip could doubtlessly and generally be established only for osteoarthrosis of the sacro-iliac joints in females beyond the age of 50 and in males as a matter of principle.

Nebel, G.; Hering, L.; Lingg, G.

1981-10-01

118

Adult degenerative and senile degenerative hyperostosis triangularis ilii  

International Nuclear Information System (INIS)

A randomised study of 2000 patients (1000 males, 1000 females) revealed two forms of the triangular hyperostosis of the ilium in female patients. The hyperostosis triangularis ilii, HTI, is also known as osteitis condensans. One form of HTI concerning women under the age of 50 is called the adult generative HTI, the other beyond the age of 50 senile degenerative HTI. These two forms are not evident in male patients. The 3.05% incidence of HTI in adults appeared to be higher than presumed till now. The sex incidence male/female of 1:1.6 diverges considerably from preceding investigations. Histomorphological studies of two autopsies of cases of senile degenerative HTI revealed no signs of inflammation. Statistical correlations of HTI with other chronic diseases of the pelvis and hip could doubtlessly and generally be established only for osteoarthrosis of the sacro-iliac joints in females beyond the age of 50 and in males as a matter of principle. (orig.)

1981-01-01

119

Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english OBJECTIVE: To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase isoforms present in herniated and degenerative discs. INTRODUCTION: Heparanase is an endo-beta-glucuronidase that specifically acts upon the heparan sulfate chains of proteoglyca [...] ns. However, heparanase expression in degenerative intervertebral discs has not yet been evaluated. Notably, previous studies demonstrated a correlation between changes in the heparan sulfate proteoglycan pattern and the degenerative process associated with intervertebral discs. METHODS: Twenty-nine samples of intervertebral degenerative discs, 23 samples of herniated discs and 12 samples of non-degenerative discs were analyzed. The expression of both heparanase isoforms (heparanase-1 and heparanase-2) was evaluated using immunohistochemistry and real-time RT-PCR analysis. RESULTS: Heparanase-1 and heparanase-2 expression levels were significantly higher in the herniated and degenerative discs in comparison to the control tissues, suggesting a possible role of these proteins in the intervertebral degenerative process. CONCLUSION: The overexpression of heparanase isoforms in the degenerative intervertebral discs and the herniated discs suggests a potential role of both proteins in the mediation of inflammatory processes and in extracellular matrix remodeling. The heparanase-2 isoform may be involved in normal metabolic processes, as evidenced by its higher expression in the control intervertebral discs relative to the expression of heparanase-1.

Luciano Miller Reis, Rodrigues; Thérèse Rachell, Theodoro; Leandro Luongo, Matos; Ana Maria, Mader; Carlo, Milani; Maria Aparecida da Silva, Pinhal.

120

Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease  

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Full Text Available OBJECTIVE: To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase isoforms present in herniated and degenerative discs. INTRODUCTION: Heparanase is an endo-beta-glucuronidase that specifically acts upon the heparan sulfate chains of proteoglycans. However, heparanase expression in degenerative intervertebral discs has not yet been evaluated. Notably, previous studies demonstrated a correlation between changes in the heparan sulfate proteoglycan pattern and the degenerative process associated with intervertebral discs. METHODS: Twenty-nine samples of intervertebral degenerative discs, 23 samples of herniated discs and 12 samples of non-degenerative discs were analyzed. The expression of both heparanase isoforms (heparanase-1 and heparanase-2 was evaluated using immunohistochemistry and real-time RT-PCR analysis. RESULTS: Heparanase-1 and heparanase-2 expression levels were significantly higher in the herniated and degenerative discs in comparison to the control tissues, suggesting a possible role of these proteins in the intervertebral degenerative process. CONCLUSION: The overexpression of heparanase isoforms in the degenerative intervertebral discs and the herniated discs suggests a potential role of both proteins in the mediation of inflammatory processes and in extracellular matrix remodeling. The heparanase-2 isoform may be involved in normal metabolic processes, as evidenced by its higher expression in the control intervertebral discs relative to the expression of heparanase-1.

Luciano Miller Reis Rodrigues

2011-01-01

 
 
 
 
121

Single-level degenerative cervical disc disease and driving disability: results from a prospective, randomized trial.  

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Study Design?Post hoc analysis of prospective, randomized trial. Objective?To investigate the disability associated with driving and single-level degenerative, cervical disc disease and to investigate the effect of surgery on driving disability. Methods?Post hoc analysis of data obtained from three sites participating in a multicenter, randomized, controlled trial comparing cervical disc arthroplasty (TDA) with anterior cervical discectomy and fusion (ACDF). The driving subscale of the Neck Disability Index (NDI) was analyzed for all patients. A dichotomous severity score was created from the NDI. Statistical comparisons were made within and between groups. Results?Two-year follow-up was available for 118/135 (87%) patients. One half of the study population (49.6%) reported moderate or severe preoperative driving difficulty. This disability associated with driving was similar among the two groups (ACDF: 2.5?±?1.1, TDA: 2.6?±?1.0, p?=?0.646). The majority of patients showed improvement, with no or little driving disability, at the sixth postoperative week (ACDF: 75%, TDA: 90%, p?=?0.073). At no follow-up point did a difference exist between groups according to the severity index. Conclusions?Many patients suffering from radiculopathy or myelopathy from cervical disc disease are limited in their ability to operate an automobile. Following anterior cervical spine surgery, most patients are able to return to comfortable driving at 6 weeks. PMID:24436875

Kelly, Michael P; Mitchell, M David; Hacker, Robert J; Riew, K Daniel; Sasso, Rick C

2013-12-01

122

Cerebrospinal fluid nitric oxide metabolites are novel predictors of pain relief in degenerative lumbar diseases.  

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This study was undertaken to determine whether or not nitric oxide metabolites (NO(2)(-) plus NO(3)(-): NOx levels) in cerebrospinal fluid (CSF) would be predictors of treatment outcome in patients with degenerative lumbar diseases (DLD) including lumbar disc herniation (LDH) and lumbar spinal canal stenosis (LCS). The NOx levels in CSF were measured using an NO analyzer based on the Griess method. Six healthy volunteers and 18 patients with painless diseases were included in the control group. The pre- and postoperative NOx levels in 25 DLD patients, who underwent herniotomy for LDH (17 patients) or selective decompression for LCS (eight patients), were analyzed. The postoperative follow-up periods were approximately 8 months. Nineteen of 25 DLD patients, whose preoperative NOx levels were two standard deviations higher than the mean NOx levels of an age-matched control group, were included in an NO elevated (NOE) group. Among the 25 DLD patients, the preoperative NOx levels in six patients (young LDH group) were within the normal range. The pain-related Japanese Orthopaedic Association score and the Hirabayashi recovery rate were respectively used to evaluate the pain severity and the degree of pain relief. The preoperative and changes of postoperative NOx levels in the NOE group were negatively correlated with the Hirabayashi recovery rate. Normal postoperative NOx levels and excellent pain relief were achieved in young DLD patients. In conclusion, the preoperative and changes in postoperative NOx levels are quantitative predictors of postoperative pain relief in DLD patients. PMID:11376909

Kimura, S; Watanabe, K; Yajiri, Y; Uchiyama, S; Hasegawa, K; Shibuki, K; Endo, N

2001-06-01

123

Sagittal balance of the pelvis-spine complex and lumbar degenerative diseases. A comparative study about 85 cases  

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Retrospective analysis of the spino-pelvic alignment in a population of 85 patients with a lumbar degenerative disease. Several previous publications reported the analysis of spino-pelvic alignment in the normal and low back pain population. Data suggested that patients with lumbar diseases have variations of sagittal alignment such as less distal lordosis, more proximal lumbar lordosis and a more vertical sacrum. Nevertheless most of these variations have been reported without reference to t...

Barrey, Ce?dric; Jund, Je?ro?me; Noseda, Olivier; Roussouly, Pierre

2007-01-01

124

Mesenchymal stem cells in joint disease and repair.  

Science.gov (United States)

Osteoarthritis (OA), a prevalent chronic condition with a striking impact on quality of life, represents an enormous societal burden that increases greatly as populations age. Yet no approved pharmacological intervention, biologic therapy or procedure prevents the progressive destruction of the OA joint. Mesenchymal stem cells (MSCs)-multipotent precursors of connective tissue cells that can be isolated from many adult tissues, including those of the diarthrodial joint-have emerged as a potential therapy. Endogenous MSCs contribute to maintenance of healthy tissues by acting as reservoirs of repair cells or as immunomodulatory sentinels to reduce inflammation. The onset of degenerative changes in the joint is associated with aberrant activity or depletion of these cell reservoirs, leading to loss of chondrogenic potential and preponderance of a fibrogenic phenotype. Local delivery of ex vivo cultures of MSCs has produced promising outcomes in preclinical models of joint disease. Mechanistically, paracrine signalling by MSCs might be more important than differentiation in stimulating repair responses; thus, paracrine factors must be assessed as measures of MSC therapeutic potency, to replace traditional assays based on cell-surface markers and differentiation. Several early-stage clinical trials, initiated or underway in 2013, are testing the delivery of MSCs as an intra-articular injection into the knee, but optimal dose and vehicle are yet to be established. PMID:23881068

Barry, Frank; Murphy, Mary

2013-10-01

125

Quantitative analysis of CT scan in degenerative diseases of the nervous system  

International Nuclear Information System (INIS)

Quantitative analysis was made on cranial CT scans of 142 patients with spinocerebellar degeneration (SCD), 16 with dentato-rubro-pallido-luysian atrophy (DRPLA), 12 with Huntington's chorea (HC), and four with chorea-acanthocytosis (CA). One hundred sex- and age-matched persons without any neurologic signs served as controls. Regarding parameters for atrophy in the infratentorial brain tissue, there was statistically significant difference between the SCD group and the control group. This indicated remarkable atrophy in the cerebellum and brain stem in SCD. According to subgroups of SCD, both bilateral atrophy of the pons and dilation of the prepontine cistern were significantly greater in the group of sporadic olivo-ponto-cerebellar atrophy than the group of Menzel type of olivo-ponto-cerebellar atrophy. The subgroup of hereditary spastic paraplegia had the mildest atrophy of the brain on CT, although there was still a significant atrophy compared with controls. In the DRPLA group, finding in the infratentorial brain tissue were similar to those in the SCD group. The HC group was characterized by having the greatest atrophy in the lateral ventricle, especially the caudate nuclei. Similar findings were seen in the CA group, although atrophy was generally mild. The results indicate the usefulness of quantitative analysis on CT in the diagnosis of degenerative diseases of the nervous system. (Namekawa, K.)

1988-01-01

126

Radiopharmaceuticals for SPECT exploration of dopaminergic systems. Diagnosis and surveillance of neuro-degenerative diseases  

International Nuclear Information System (INIS)

New radiopharmaceuticals were developed to explore the pre- or post-synaptic slopes of the dopaminergic terminations. At present, their interest is recognized for the differential diagnosis of the extra-pyramidal syndromes. Other various applications in neurology and psychiatry are in view. On the pre-synaptic slope, implied in the Parkinson's disease, the dopamine carrier, able to be visualized due to its iodine derivatives of cocaine, is localized. The ?CIT, which is presently the best known specificity-free derivative, has actually an equivalent affinity for the dopamine carrier and the serotonin carrier. Besides, its kinetic does not allow its imaging in the day of injection. We have developed and validated another derivative, the PE2I: N-(3-Iodoprop-(2E)-enyl) -2?-carbometoxy -3?-(4'-methyl-phenyl) nortropane which displays the properties required by kinetic and specificity. On the post-synaptic slope the type-D2 dopaminergic receptors were localized, which can be explored by means of (iodolisuride) ergolenes and benzamide derivatives (IBZM). These ligands have not an AMM yet, therefore their utilization may be approached by magistral preparation. The scintigraphy of the D2 receptors and dopamine carrier could be useful for the earlier diagnosis and the therapeutic surveillance of the neuro-degenerative decease. The coupling of the pre- and post-synaptic scintigraphies may be taken into consideration to augment diagnosis potentiality

1997-10-01

127

Surgical treatment of degenerative cervical spine diseases: Analyses of 90 patients clinical study  

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Full Text Available The effect of degenerative cervical spine surgery depends on good understanding of the pathogenesis and clinical course of disease with a detailed neurological and neuroradiological examination. Surgical approach should be considered separately for each pathological substrate in order to avoid additional morbidity. The aim of our study is to present the results of treatment through analysis of large clinical series focusing on anterior surgical approach with iliac crest graft fusion without cervical plating. The retrospective analysis of 90 patients operated on Neurosurgery of CHC Zemun, from 2008 to 2011, was done. In 81 patients cervical disc herniation was found in one or two levels, and 9 patients had spinal canal stenosis with polydiscopathy. Preoperatively 50 patients had cervical myelopathy, and 40 patients had radiculopathy as dominating clinical sign. Anterior cervical approach was performed in 79 patients, and 11 patients were operated by posterior approach. The treatment outcome was as follows: good outcome 16 (16.8% patients, improved condition 65 (72.2%, without improvement 6 (6.7%, bad outcome 3 (4.3%. The anterior cervical approach with iliac crest autologous graft fusion, and without additional cervical plating, is reliable treatment option with results comparable to reported clinical series with sintetic graft placement and anterior cervical plate stabilisation.

Markovi? M.

2012-01-01

128

Differentiation of malignant and degenerative benign bone disease using Tc-99m Citrate and Tc-99m MDP scintigraphy  

International Nuclear Information System (INIS)

Full text: For the evaluation of bone metastases in patients (pts) with cancer, 99mTcMDP bone scintigraphy is an important tool, but some limitations exist. One of these is the differential diagnosis of malignant and degenerative benign bone disease. The aim of this study was to differentiate them using 99mTcCitrate and 99mTcMDP scintigraphy. Methods: 39 pts (92 lesions) with known malignant or degenerative benign bone disease were studied. 23 pts had malignant bone disease (48 lesions, group 1), the other 16 pts had degenerative benign bone disease (44 lesions, group2), for which the results of 99mTcMDP scintigraphy were positive. In both groups, 99mTcCitrate scintigraphy was performed within a time interval of 2-7 days after 99mTcMDP scintigraphy (555?740MBq. static, 3hr, planar or SPECT i m a g e s w h e n r e q u i r e d ) . The 99mTccitrate/99mTcMDP lesion-to-background radioisotope uptake ratio (RUR) was calculated for each lesion. Conventional techniques (histopathology, X-ray, CT, MRI and clinical follow up) were considered to be proof of the presence of bone metastases and degenerative benign bone disease. Results: Uptake of 99mTcMDP in the two groups is the same (1.96±0.25 vs. 1.87±0.21; t=1.178, P>0.20), while in 99mTcCitrate image, malignant lesions demonstrated a higher uptake of lesion activity than that of benign degenerative lesions (1.47±0.42 vs. 1.09±0.38; t=2.887, P<0.01). The mean 99mTccitrate/99mTcMDP RUR in the malignant group was significantly higher than the mean in the benign group (0.78±0.21 vs. 0.54±0.19; t=3.646, P<0.001). Conclusions: The preliminary results of the study confirm the usefulness and feasibility of 99mTcCitrate scintigraphy for differentiating malignant from benign degenerative lesions seen as areas of increased activity on 99mTcMDP bone scintigraphy. (author)

2007-07-01

129

Plain-film diagnosis of joint disease  

International Nuclear Information System (INIS)

The authors describe a systematic approach to plain-film diagnosis of joint disease. The major radiologic criteria - soft-tissue swelling, joint-space narrowing, bone erosion, bone sclerosis and osteophytosis, and chondrocalcinosis - are considered first. Assessing the involvement of the minor criteria of joint disease - soft-tissue atrophy or calcification, malalignment, osteoporosis, abnormal growth, intra-articular bony ankylosis, bon fragmentation, periostitis, subperiosteal resorption or acro-osteolysis -narrows the probabilities to the more likely diagnoses. Further analysis includes the distribution of joint injury, whether mono- or polyarticular, symmetrical or asymmetrical. Added to clinical information, this approach leads to a specific or refined differential diagnosis. (47 refs., 11 figs.)

1991-04-01

130

Yoga and disc degenerative disease in cervical and lumbar spine: an MR imaging-based case control study  

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The objective of the current study was to find out whether yoga practice was beneficial to the spine by comparing degenerative disc disease in the spines of long-time yoga practitioners and non-yoga practicing controls, using an objective measurement tool, magnetic resonance imaging. This matched case–control study comprised 18 yoga instructors with teaching experience of more than 10 years and 18 non-yoga practicing asymptomatic individuals randomly selected from a health checkup database...

Jeng, Chin-ming; Cheng, Tzu-chieh; Kung, Ching-huei; Hsu, Hue-chen

2011-01-01

131

Degenerative Mitral Valve Repair  

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Full Text Available Degenerative mitral regurgitation (MR is a rather common pathology1. If untreated, severe MR leads to left ventricular failure, pulmonary hypertension, atrial fibrillation and death 2. Correction of MR can be associated with a life expectancy and a quality of life similar to those of the normal healthy population, when performed appropriately and timely 3.In many patients, degenerative MR is characterised by an excess of valve tissue with elongated or ruptured chordae (Barlow’s disease 4, while in others, the leaflets are thinner and translucent and chordae are very fragile (fibroelastic deficiency. Mitral valve prolapse is the consequence of these anatomical alterations affecting primarily the leaflets and the subvalvular apparatus.American and European guidelines for the treatment of heart valve disease 5,6 indicate the criteria for appropriate management of patients with degenerative MR.The aim of this editorial is to briefly explore the optimal management of patients affected by degenerative MR.

Ottavio Alfieri MD.

2011-08-01

132

The Efficacy of Intradiscal Steroid Injections in Degenerative Lumbar Disc Disease  

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Full Text Available Objective: We aimed to investigate the efficacy of intradiscal steroid injection in patients with chronic low back pain due to degenerative disc disease.Materials and Methods: A total of 18 patients (9 female, 9 male with chronic low back pain of discogenic origin were enrolled in the study. The intervertebral disc level which met the diagnostic criteria for provocative discography was defined as discogenic pain level. After identification of positive disc level, 1 cc betamethasone was injected into the disc. The outcome measures (visual analog pain scale and Quebec Back Pain Disability Scale scores, finger-tip-to-floor distance and duration of sitting without pain were assessed before the treatment and at second week and third month post injection. Results: The reduction in low back pain intensity between the baseline and second week, and between the baseline and third month was statistically significant (p=0.001 and p=0.002. Besides, statistically significant improvement was observed in Quebec Disability Scores between the baseline and second week, and between the baseline and third month (p=0.001 and p=0.002. The finger-tip-to-floor distance between the baseline and second week, and between the baseline and third month showed a statistically significant improvement (p=0.002 and p=0.02. The duration of sitting without pain between the baseline and second week, and between the baseline and third month showed a statistically significant increase (p=0.001 and p=0.009. Conclusion: As a result, we suggest that intradiscal steroid injection may be effective in short-term and mid-term for reducing the intensity of spinal pain and the proportion of disability due to chronic discogenic low back pain in patients who do not respond to conservative treatment. Turk J Phys Med Re­hab 2012;58:88-92.

Ferdi Yavuz

2012-06-01

133

The Mircen project, neuro-degenerative disease: mechanisms, therapeutics and imaging research Unit URA Cea Cnrs 2210  

International Nuclear Information System (INIS)

During the post-genomic era, significant advances in our understanding of the molecular basis of disease have been made. The power of functional and molecular imaging in translating this knowledge into effective therapy is now being more and more recognized. Thus, molecular imaging plays a vital role in the early identification of disease-related molecular markers, in the development of molecular-targeted therapies, and in monitoring phenotypic response to therapy both in experimental animals and in human patients. In this context, MIRCen (acronym for Molecular Imaging Research Center ) provides a comprehensive resource available to empower basic, translational, and clinical research through the application of imaging and drug, cell, and gene based technologies. The MIR center will be dedicated to the development of pre-clinical trials for the treatment of various seriously debilitating diseases such as neuro-degenerative diseases, cardiac and hepatic disorders, and infectious diseases (AIDS). Despite the fact that many of these pathologies are still incurable, recent advances in drug, cell and gene therapy point to the feasibility of new therapeutic approaches. The long term goals of MIRCen are therefore to develop and validate: - pertinent animal models for neuro-degenerative, hepatic, cardiac and infectious diseases in rodents as well as non-human primates, - novel technologies for in vivo sensing and imaging of disease-related molecular events,- drug, gene and cell based palliative and or curative therapeutic strategies aiming at protecting and /or restoring damaged or lost functions. (author)

2006-01-01

134

The Mircen project, neuro-degenerative disease: mechanisms, therapeutics and imaging research Unit URA Cea Cnrs 2210  

Energy Technology Data Exchange (ETDEWEB)

During the post-genomic era, significant advances in our understanding of the molecular basis of disease have been made. The power of functional and molecular imaging in translating this knowledge into effective therapy is now being more and more recognized. Thus, molecular imaging plays a vital role in the early identification of disease-related molecular markers, in the development of molecular-targeted therapies, and in monitoring phenotypic response to therapy both in experimental animals and in human patients. In this context, MIRCen (acronym for Molecular Imaging Research Center ) provides a comprehensive resource available to empower basic, translational, and clinical research through the application of imaging and drug, cell, and gene based technologies. The MIR center will be dedicated to the development of pre-clinical trials for the treatment of various seriously debilitating diseases such as neuro-degenerative diseases, cardiac and hepatic disorders, and infectious diseases (AIDS). Despite the fact that many of these pathologies are still incurable, recent advances in drug, cell and gene therapy point to the feasibility of new therapeutic approaches. The long term goals of MIRCen are therefore to develop and validate: - pertinent animal models for neuro-degenerative, hepatic, cardiac and infectious diseases in rodents as well as non-human primates, - novel technologies for in vivo sensing and imaging of disease-related molecular events,- drug, gene and cell based palliative and or curative therapeutic strategies aiming at protecting and /or restoring damaged or lost functions. (author)

Hantraye, Ph. [Service Hospitalier Frederic Joliot, Isotopic Imaging, Pharmacological and Biochemical Research Unit, 91 - Orsay (France)

2006-07-01

135

Dementia neuro degenerative diseases and bio markers: a new strategy for an early diagnosis  

International Nuclear Information System (INIS)

the neuro degenerative dementia (particularly focal beginning forms) can be diagnosed earlier by analyzing the combination of the rate of phosphorylated tau protein, IITE score and perfusion in right anterior cingulate gyrus, the Broca area, and left angular gyrus. A prospective study is underway to validate this model. (N.C.)

2010-05-08

136

Comparison of the costs of nonoperative care to minimally invasive surgery for sacroiliac joint disruption and degenerative sacroiliitis in a United States Medicare population: potential economic implications of a new minimally-invasive technology  

Directory of Open Access Journals (Sweden)

Full Text Available Stacey J Ackerman1, David W Polly Jr2, Tyler Knight3, Karen Schneider4, Tim Holt5, John Cummings61Covance Market Access Services Inc, San Diego, CA, USA; 2University of Minnesota, Orthopaedic Surgery, Minneapolis, MN, USA; 3Covance Market Access Services Inc, Gaithersburg, MD, USA; 4Covance Market Access Services Inc, Sydney, NSW, Australia; 5Montgomery Spine Center, Orthopaedic Surgery, Montgomery, AL, USA; 6Community Health Network, Neurosurgery, Indianapolis, IN, USAIntroduction: The economic burden associated with the treatment of low back pain (LBP in the United States is significant. LBP caused by sacroiliac (SI joint disruption/degenerative sacroiliitis is most commonly treated with nonoperative care and/or open SI joint surgery. New and effective minimally invasive surgery (MIS options may offer potential cost savings to Medicare.Methods: An economic model was developed to compare the costs of MIS treatment to nonoperative care for the treatment of SI joint disruption in the hospital inpatient setting in the US Medicare population. Lifetime cost savings (2012 US dollars were estimated from the published literature and claims data. Costs included treatment, follow-up, diagnostic testing, and retail pharmacy pain medication. Costs of SI joint disruption patients managed with nonoperative care were estimated from the 2005–2010 Medicare 5% Standard Analytic Files using primary International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM diagnosis codes 720.2, 724.6, 739.4, 846.9, or 847.3. MIS fusion hospitalization cost was based on Diagnosis Related Group (DRG payments of $46,700 (with major complications - DRG 459 and $27,800 (without major complications - DRG 460, weighted assuming 3.8% of patients have complications. MIS fusion professional fee was determined from the 2012 Medicare payment for Current Procedural Terminology code 27280, with an 82% fusion success rate and 1.8% revision rate. Outcomes were discounted by 3.0% per annum.Results: The extrapolated lifetime cost of treating Medicare patients with MIS fusion was $48,185/patient compared to $51,543/patient for nonoperative care, resulting in a $660 million savings to Medicare (196,452 beneficiaries at $3,358 in savings/patient. Including those with ICD-9-CM code 721.3 (lumbosacral spondylosis increased lifetime cost estimates (up to 478,764 beneficiaries at $8,692 in savings/patient.Conclusion: Treating Medicare beneficiaries with MIS fusion in the hospital inpatient setting could save Medicare $660 million over patients' lifetimes.Keywords: sacroiliac joint disruption, degenerative sacroiliitis, minimally invasive surgery, epidural injection, iFuse, cost

Ackerman SJ

2013-11-01

137

Clinical results of posterolateral fusion for degenerative lumbar spinal diseases. A follow-up study of more than 10 years  

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The objective of this retrospective study was to evaluate the long-term clinical outcomes and the effects on unfused motion segments of posterolateral fusion. This study involved 35 cases (37 intervertebral levels) of posterolateral fusion performed to treat degenerative lumbar spinal diseases. There were 20 male and 15 female patients ranging in age from 30 to 67 years, with a mean age of 49 years. The postoperative period ranged from 10 years to 17 years and 8 months, with a mean period of 13 years. The clinical outcomes were evaluated using the Japanese Orthopaedic Association (JOA) score for assessment of treatment for low back pain. The effects on unfused motion segments were investigated with radiographic and magnetic resonance (MR) imaging. Postoperative satisfactory improvement (mean recovery rate, 66.9%) reached a plateau at 1 year and was maintained at final follow-up. Radiographically, the union rate was 86.5%. There were few cases of induced instability of unfused motion segments. On MR imaging, increased signal intensity in both T{sub 1}- and T{sub 2}-weighted images was seen in the paravertebral muscles in 15 of 20 cases (75.0%). Posterolateral fusion is a useful technique for the treatment of degenerative lumbar spinal diseases. Clinical outcomes were stable throughout follow-up. Instability of unfused motion segments rarely occurred. (author)

Kuroki, Hiroshi; Tajima, Naoya; Kubo, Shinichiro [Miyazaki Medical Coll., Kiyotake (Japan)

2002-07-01

138

Clinical results of posterolateral fusion for degenerative lumbar spinal diseases. A follow-up study of more than 10 years  

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The objective of this retrospective study was to evaluate the long-term clinical outcomes and the effects on unfused motion segments of posterolateral fusion. This study involved 35 cases (37 intervertebral levels) of posterolateral fusion performed to treat degenerative lumbar spinal diseases. There were 20 male and 15 female patients ranging in age from 30 to 67 years, with a mean age of 49 years. The postoperative period ranged from 10 years to 17 years and 8 months, with a mean period of 13 years. The clinical outcomes were evaluated using the Japanese Orthopaedic Association (JOA) score for assessment of treatment for low back pain. The effects on unfused motion segments were investigated with radiographic and magnetic resonance (MR) imaging. Postoperative satisfactory improvement (mean recovery rate, 66.9%) reached a plateau at 1 year and was maintained at final follow-up. Radiographically, the union rate was 86.5%. There were few cases of induced instability of unfused motion segments. On MR imaging, increased signal intensity in both T1- and T2-weighted images was seen in the paravertebral muscles in 15 of 20 cases (75.0%). Posterolateral fusion is a useful technique for the treatment of degenerative lumbar spinal diseases. Clinical outcomes were stable throughout follow-up. Instability of unfused motion segments rarely occurred. (author)

2002-01-01

139

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 1: Introduction and methodology.  

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Fusion procedures are an accepted and successful management strategy to alleviate pain and/or neurological symptoms associated with degenerative disease of the lumbar spine. In 2005, the first version of the "Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine" was published in the Journal of Neurosurgery: Spine. In an effort to incorporate evidence obtained since the original publication of these guidelines, an expert panel of neurosurgical and orthopedic spine specialists was convened in 2009. Topics reviewed were essentially identical to the original publication. Selected manuscripts from the first iteration of these guidelines as well as relevant publications between 2005 through 2011 were reviewed. Several modifications to the methodology of guideline development were adopted for the current update. In contrast to the 2005 guidelines, a 5-tiered level of evidence strategy was employed, primarily allowing a distinction between lower levels of evidence. The qualitative descriptors (standards/guidelines/options) used in the 2005 recommendations were abandoned and replaced with grades to reflect the strength of medical evidence supporting the recommendation. Recommendations that conflicted with the original publication, if present, were highlighted at the beginning of each chapter. As with the original guideline publication, the intent of this update is to provide a foundation from which an appropriate treatment strategy can be formulated. PMID:24980578

Kaiser, Michael G; Eck, Jason C; Groff, Michael W; Watters, William C; Dailey, Andrew T; Resnick, Daniel K; Choudhri, Tanvir F; Sharan, Alok; Wang, Jeffrey C; Mummaneni, Praveen V; Dhall, Sanjay S; Ghogawala, Zoher

2014-07-01

140

Development of PET tracers for neuro inflammation imaging in neuro degenerative diseases  

International Nuclear Information System (INIS)

Inflammatory processes such as micro-glial or endothelial activation are involved in many neuro-degenerative conditions. Neuro-inflammation imaging is considered an attractive tool for fundamental research, diagnosis and therapeutic evaluation in neuro-pathologies. First, an aptamer was selected against a recombinant fragment of the endothelial target VCAM-1, but proved unable to bind the target protein in native conformation, as expressed by a cell line. Second, five radioligands of the peripheral benzodiazepine receptor (PBR), a marker of micro-glial activation, were evaluated in vivo using PET (Positron Emission Tomography) imaging in a rat model of neuro-inflammation, and were compared to [11C]PK11195. Four radiotracers displayed a better contrast than [11C]PK11195. In a competitive field of research, this work demonstrates the efficiency of in vivo screening of radiotracers for fast selection of clinically relevant molecules. (author)

2007-01-01

 
 
 
 
141

Quantitative magnetic resonance imaging and studies of degenerative diseases of the developing human brain  

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The Rett syndrome is a progressive disorder which is associated with regression of psychomotor development and precipitous deceleration of brain growth during the first year of life. General histopathological surveys in postmortem specimens have identified degeneration of subpopulations of neurons of the nigrostriatal system but no other evidence of degenerative process. Magnetic resonance imaging-based morphometry may usefully guide application of rigorous but demanding quantitative histologic search for evidence of neuronal degeneration. The volumes of the principal set of cortical and nuclear structures of principal interest in the disorder may be measured by currently avaiable MRI-based methods. Opimized levels of precision now allow detection of volumetric changes over time in the same brain of approximately 10% at the 95% confidence level. (author)

1992-01-01

142

Role of the C-Terminus of the Photoreceptor ABCA4 Transporter in Protein Folding, Function and Retinal Degenerative Diseases*  

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ABCA4 is an ATP binding cassette (ABC) transporter that is expressed in rod and cone photoreceptor cells and implicated in the removal of retinal derivatives from outer segments following photoexcitation. Mutations in the ABCA4 gene are responsible for a number of related retinal degenerative diseases including Stargardt macular degeneration, cone-rod dystrophy, retinitis pigmentosa, and age-related macular degeneration. In order to determine the role of the C-terminus of ABCA4 in protein structure and function and understand mechanisms by which C-terminal mutations cause retinal degenerative diseases, we have expressed and purified a series of deletion and substitution mutants of ABCA4 and ABCA1 in HEK 293T cells for analysis of their cellular localization and biochemical properties. Removal of the C-terminal 30 amino acids of ABCA4 including a conserved VFVNFA motif resulted in the loss in N-retinylidene-phosphatidylethanolamine substrate binding, ATP photoaffinity labeling, and retinal stimulated ATPase activity. This mutant was also retained in the endoplasmic reticulum (ER) of cells. Replacement of the VFVNFA motif with alanine residues also resulted in loss in function and cellular mislocalization. In contrast C-terminal deletion mutants that retain the VFVNFA motif were functionally active and localized to intracellular vesicles similar to wild-type ABCA4. Our studies indicated that the VFVNFA motif is required for the proper folding of ABCA4 into a functionally active protein. This motif also contributes to the efficient folding of ABCA1 into an active protein. Our results provide a molecular based rationale for the disease phenotype displayed by individuals with mutations in the C-terminus of ABCA4.

Zhong, Ming; Molday, Laurie L.; Molday, Robert S.

2014-01-01

143

Risk factors for the development of adjacent segment disease following anterior cervical arthrodesis for degenerative cervical disease: comparison between fusion methods.  

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This study aimed to determine the risk factors for developing adjacent segment disease (ASDz) after anterior cervical arthrodesis for the treatment of degenerative cervical disease by analyzing patients treated with various fusion methods. We enrolled 242 patients who had undergone anterior cervical fusion for degenerative cervical disease, and had at least 5years of follow-up. We evaluated the development of ASDz and the rate of revision surgery. To identify the risk factors for ASDz, the sagittal alignment, spinal canal diameter, range of motion of the cervical spine, number of fusion segments, and fusion methods were evaluated. The patients were divided into three groups according to the fusion method: Group A contained patients who had received autogenous bone graft only (53 patients), Group B contained patients who received autogenous bone graft and plate augmentation (62 patients), and Group C contained patients who underwent cage and plate augmentation (127 patients). ASDz occurred in 33 patients, of whom 19 required additional surgery. The risk of developing ASDz was significantly higher in male patients (p=0.043), patients whose range of motion of the cervical spine was >30° (p=0.027), and patients with spinal canal stenosis (p=0.010). The rate of development of ASDz was not different depending on the number of fusion segments. The rate of development of ASDz was 41.5% in Group A, 9.6% in Group B, and 5.51% in Group C (p=0.03). In patients who underwent anterior cervical arthrodesis for degenerative disease, the occurrence of ASDz was related to age, the cervical spine range of motion, and spinal canal stenosis. Additional plate augmentation for anterior cervical arthrodesis surgery can lower the rate of ASDz development. PMID:24331625

Song, Ji-Soo; Choi, Byung-Wan; Song, Kyung-Jin

2014-05-01

144

Can facet joint infiltrative analgesia reduce postoperative pain in degenerative lumbar disc surgery? / ¿Puede reducirse el dolor postoperatorio en la cirugía discal degenerativa lumbar con infiltración de analgésicos?  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: English Abstract in spanish Objetivo. La analgesia peroperatoria influye en el curso del dolor postquirúrgico. El propósito del estudio reside en la evaluación de la posible relación entre el consumo de dolantina y otros analgésicos en el control del dolor postquirúrgico de origen facetario lumbar en la enfermedad discal degen [...] erativa. Métodos. Empleamos peroperatoriamente infiltra- ciones percutáneas de bupivacaína intra y perifacetaria para reducir el dolor postoperartorio tras cirugía discal lumbar. El estudio fue randomizado y oculto al observador y se realizó sobre 40 pacientes operados de cirugía electiva por enfermedad degenerativa lumbar, con una situación general Clase I-II de la clasifica-ción de la American Society of Anesthesiologist. Los pacientes se dividieron en dos grupos de 20 .El Grupo 1 se le administró bupivacaína en el tejido subcutáneo y capas musculares. El grupo 2 recibió una inyección adicional de bupivacaína intra y perifacetaria. Durante el postoperatorio, los pacientes, dispusieron de una bomba programable de analgesia controlada, que se activó exclusivamente a demanda para infundir dolantina en las 24 horas siguientes a la operación. En la Unidad de Reanimación postquirúrgicas se recogieron las necesidades de dolantina de los distintos pacientes. Resultados. No se encontraron diferencias esta- dísticamente significativas entre ambos grupos en relación a los valores de la escala analógica visual. El tiempo de demanda del primer bolo analgésico fue significativamente mayor en el grupo de facetas infiltradas (p=0,006). La acumulación de las dosis de dolantina fue también significativamente inferior en el grupo de facetas infiltradas (p=0.001). Conclusión. Los resultados indican que la infiltración de la faceta articular con anestésico local puede tener un efecto positivo reduciendo las necesidades analgésicas postoperatorias de dolantina. Abstract in english Objective. Perioperative analgesia effects the postoperative course of pain. The purpose of this study was to evaluate its possible relation with the consumption of dolantine and analgesics and the facet-induced pain and postoperative pain score in degenerative disc surgery. Methods. We employed per [...] ioperative intra- and perifacet bupivacaine infiltration technique to reduce the postoperative pain after lumbar disc surgery. The study was randomized and observer blinded enrolling 40 American Society of Anesthesiologists physical status class I-II patients scheduled for elective degenerative lumbar disc surgery. The patients were divided into two groups of 20 of which Group 1 underwent injection of bupivacaine into the subcutaneous and muscular layers around the incision site, while Group 2 underwent additional intra- and perifacetal joint infiltration. Postoperatively, the patients were provided with a programmed patient-controlled pump which was only activated on demand to infuse dolantine for the next 24 hours. In the postanesthesia care unit the delay for analgesia and the dose of dolantine used were recorded. Results. There was no statistical significance between these two groups regarding postoperative visual analoque scale scores. The time before the first analgesic request was significantly longer in facet group (p= 0,006). The cumulative dolantine dose was also significantly lower in the facet group (p= 0,001) Conclusion. The results indicate that facet joint infiltrative analgesia may have an effect on the postoperative analgesic requirement and reduce the dolantine consumption.

G., Bademci; H., Basar; S., Sahin; S., Ozcakir; H., Anbarci; C., Evliyaoglu; S., Keskil.

145

Identification of gene co-regulatory modules and associated cis-elements involved in degenerative heart disease  

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Full Text Available Abstract Background Cardiomyopathies, degenerative diseases of cardiac muscle, are among the leading causes of death in the developed world. Microarray studies of cardiomyopathies have identified up to several hundred genes that significantly alter their expression patterns as the disease progresses. However, the regulatory mechanisms driving these changes, in particular the networks of transcription factors involved, remain poorly understood. Our goals are (A to identify modules of co-regulated genes that undergo similar changes in expression in various types of cardiomyopathies, and (B to reveal the specific pattern of transcription factor binding sites, cis-elements, in the proximal promoter region of genes comprising such modules. Methods We analyzed 149 microarray samples from human hypertrophic and dilated cardiomyopathies of various etiologies. Hierarchical clustering and Gene Ontology annotations were applied to identify modules enriched in genes with highly correlated expression and a similar physiological function. To discover motifs that may underly changes in expression, we used the promoter regions for genes in three of the most interesting modules as input to motif discovery algorithms. The resulting motifs were used to construct a probabilistic model predictive of changes in expression across different cardiomyopathies. Results We found that three modules with the highest degree of functional enrichment contain genes involved in myocardial contraction (n = 9, energy generation (n = 20, or protein translation (n = 20. Using motif discovery tools revealed that genes in the contractile module were found to contain a TATA-box followed by a CACC-box, and are depleted in other GC-rich motifs; whereas genes in the translation module contain a pyrimidine-rich initiator, Elk-1, SP-1, and a novel motif with a GCGC core. Using a naïve Bayes classifier revealed that patterns of motifs are statistically predictive of expression patterns, with odds ratios of 2.7 (contractile, 1.9 (energy generation, and 5.5 (protein translation. Conclusion We identified patterns comprised of putative cis-regulatory motifs enriched in the upstream promoter sequence of genes that undergo similar changes in expression secondary to cardiomyopathies of various etiologies. Our analysis is a first step towards understanding transcription factor networks that are active in regulating gene expression during degenerative heart disease.

Danko Charles G

2009-05-01

146

Degenerative diseases of the spine. Rare and often unrecognized causes of pain syndromes  

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The aim of this article is to describe rare and often unrecognized causes of spinal pain syndromes. Intervertebral disc degeneration frequently appears in early adulthood and can have a symptomatic or asymptomatic course. This article discusses incidence, pathophysiology, imaging, and pain symptomatology involved in the origin of back pain. Anulus tears are often found in asymptomatic individuals but could be implicated in lumbar pain symptomatology in correlation with the provocative discography. Transient disorders can lead to pseudarthrosis of the iliac bone and to degeneration or to a reactive hypermobility with intervertebral disc degeneration in the level above. Modic type 1 erosive osteochondrosis is characterized by bone marrow edema near the hyaline cartilage end plate, which mostly elicits severe pain and results in serious limitations in everyday activities. The most important differential diagnosis is spondylodiscitis. Schmorl's nodes can exhibit considerable surrounding bone marrow edema that can be mistaken for metastases. A combination of MRI and CT should be employed for the diagnostic work-up of fatigue fracture of the interarticular portion, which is often overlooked due to its location. Synovial cysts of the facet joints can lead to radicular symptoms. Insufficiency fracture of the sacrum is frequently mistaken for metastasis due to intense scintigraphic enhancement and its signal behavior in MRI. CT provides instructive information. Differential diagnosis should include less common causes such as anulus tears, transient disorders, activated Schmorl's nodes, synovial cysts of the facet joints, fatigue fractures of the interarticular portion of the spine and the sacrum and distinguish from metastases in particular. (orig.)

2006-06-01

147

Histone acetylation as a potential therapeutic target in motor neuron degenerative diseases.  

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Among hereditary diseases, the group of motor neuron diseases (MNDs) includes some of the most devastating and rapidly progressive lethal conditions. Although degeneration of motor neurons is common to all of them, the phenotypic spectrum of MNDs is relatively broad and ranges from perinatal conditions like spinal muscular atrophy (SMA) to adult-onset diseases such as amyotrophic lateral sclerosis (ALS). While the understanding of the pathology of the diseases is constantly growing, the development of therapeutic approaches lags behind. In fact, there is no approved therapy for MNDs available at the moment. Recent findings demonstrated the existence of some patterns that are shared by several MNDs such as transcriptional dysregulation. In addition, conditions like SMA or certain types of Charcot-Marie-Tooth disease provide some defined targets which may be amenable to therapeutic approaches. Consequently, counteracting this dysregulation may be a valuable therapeutic option and ameliorate disease progression in MND patients. The feasibility of such an approach has been proven during the past years by the epigenetic treatment of various neoplastic entities with histone deacetylase inhibitors (HDACi). On these grounds, also epigenetic therapy of MNDs has become a promising option. So far, several HDACi have been tested in vitro and in animal models and some proceeded further and were evaluated in clinical trials. This review will summarize the advances of HDACi in MNDs and will give a perspective where the road will lead us. PMID:23448465

Garbes, Lutz; Riessland, Markus; Wirth, Brunhilde

2013-01-01

148

Canine degenerative myxomatous mitral valve disease: natural history, clinical presentation and therapy.  

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Myxomatous mitral valve disease is a common condition in geriatric dogs. Most dogs affected are clinically asymptomatic for a long time. However, about 30% of these animals present a progression to heart failure and eventually die as a consequence of the disease. Left atrial enlargement, and particularly a change in left atrial size, seems to be the most reliable predictor of progression in some studies, however further studies are needed to clarify how to recognize asymptomatic patients at higher risk of developing heart failure. According to the published data on the natural history of the disease and the results of published studies evaluating the effect of early therapy on delaying the progression of the disease, it seems that no currently available treatment delays the onset of clinical signs of congestive heart failure (CHF). Although the ideal treatment of more severely affected dogs is probably surgical mitral valve repair or mitral valve replacement, this is not a currently available option. The results of several clinical trials together with clinical experience suggest that dogs with overt CHF can be managed with acceptable quality of life for a relatively long time period with medical treatment including furosemide, an angiotensin-converting enzyme inhibitor, pimobendan, and spironolactone. PMID:20610017

Borgarelli, Michele; Haggstrom, Jens

2010-07-01

149

Repackaging FDA-approved drugs for degenerative diseases: promises and challenges.  

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Repurposing refers to the therapeutic use of a drug or drug candidate for a disease other than that for which it was originally intended. Repurposing is attractive as a drug development strategy since much is known about approved agents including their drug-likeness and pharmacokinetic features, dosing, safety, tolerability, formulation and manufacturing. Time savings are also robust accounting for several years of the drug development cycle. Tissue and cell-based assays, epidemiologic information and human studies identify approved drugs that might be repurposed from use in Alzheimer's disease and other neurodegenerative disorders. The total number of compounds available for repurposing that are brain-penetrant is relatively small. Intellectual property and patent protection issues for repurposed drugs are hurdles for this approach to drug development. Repurposing may contribute importantly to development of new therapies for neurodegenerative disorders. PMID:24502586

Cummings, Jeffrey L; Zhong, Kate

2014-03-01

150

Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases  

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Semaphorins are a large family of transmembrane proteins. The gene for SEMA4A encodes a transmembrane protein comprising 760 amino acids. To investigate its association with human retinal degeneration, mutation screening of the SEMA4A gene was carried out on 190 unrelated patients suffering from a variety of eye diseases. We report the first observation of the involvement of SEMA4A gene mutations causing retinitis pigmentosa (RP) and cone rod dystrophy (CRD). We screened the DNA of 135 patien...

Abid, A.; Ismail, M.; Mehdi, S. Q.

2006-01-01

151

Comparison of the costs of nonoperative care to minimally invasive surgery for sacroiliac joint disruption and degenerative sacroiliitis in a United States Medicare population: potential economic implications of a new minimally-invasive technology  

Science.gov (United States)

Introduction The economic burden associated with the treatment of low back pain (LBP) in the United States is significant. LBP caused by sacroiliac (SI) joint disruption/degenerative sacroiliitis is most commonly treated with nonoperative care and/or open SI joint surgery. New and effective minimally invasive surgery (MIS) options may offer potential cost savings to Medicare. Methods An economic model was developed to compare the costs of MIS treatment to nonoperative care for the treatment of SI joint disruption in the hospital inpatient setting in the US Medicare population. Lifetime cost savings (2012 US dollars) were estimated from the published literature and claims data. Costs included treatment, follow-up, diagnostic testing, and retail pharmacy pain medication. Costs of SI joint disruption patients managed with nonoperative care were estimated from the 2005–2010 Medicare 5% Standard Analytic Files using primary International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis codes 720.2, 724.6, 739.4, 846.9, or 847.3. MIS fusion hospitalization cost was based on Diagnosis Related Group (DRG) payments of $46,700 (with major complications - DRG 459) and $27,800 (without major complications - DRG 460), weighted assuming 3.8% of patients have complications. MIS fusion professional fee was determined from the 2012 Medicare payment for Current Procedural Terminology code 27280, with an 82% fusion success rate and 1.8% revision rate. Outcomes were discounted by 3.0% per annum. Results The extrapolated lifetime cost of treating Medicare patients with MIS fusion was $48,185/patient compared to $51,543/patient for nonoperative care, resulting in a $660 million savings to Medicare (196,452 beneficiaries at $3,358 in savings/patient). Including those with ICD-9-CM code 721.3 (lumbosacral spondylosis) increased lifetime cost estimates (up to 478,764 beneficiaries at $8,692 in savings/patient). Conclusion Treating Medicare beneficiaries with MIS fusion in the hospital inpatient setting could save Medicare $660 million over patients’ lifetimes.

Ackerman, Stacey J; Polly, David W; Knight, Tyler; Schneider, Karen; Holt, Tim; Cummings, John

2013-01-01

152

Neurochemical imaging of Alzheimer`s disease and other degenerative dementias  

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A wide variety of neurochemical and functional imaging approaches have been applied to the study of progressive dementias, particularly Alzheimer`s disease (Ad) and related disorders. Despite considerable progress in the past decade, the cause(s) of most cases of Ad remain undetermined and preventive or protective therapies are lacking. Specifically-designed imaging procedures have permitted the testing of pathophysiological hypotheses of the etiology and progression of Ad, and have yielded important insights in several areas including the potential roles of cerebral cortical cholinergic lesions, cellular inflammation, and losses of cortical synapses. From the perspective of clinical diagnosis, PET glucose metabolism imaging with use of ({sup 18}F)2-fluorodeoxyglucose (FDG) is the most sensitive and specific imaging modality yet identified. The overall performance of PET FDG is favorable for routine clinical evaluation of suspected Ad, and will likely gain increasing utilization in the near future. Assessments of glucose metabolism and other, specific aspects of neurochemistry in Ad will provide direct measures of therapeutic drug actions and may permit distinction of symptomatic versus disease-modifying therapies as they are developed and introduced in clinical trials.

Frey, K.A.; Minoshima, S.; Kuhl, D.E. [Ann Arbor, Univ. of Michigan, MI (United States). Dept. of Internal Medicine. Division of Nuclear Medicine

1998-09-01

153

Nuclear magnetic resonance in the evaluation of the disk luxation in the temporomandibular articulation conditioned for degenerative osseous changes  

International Nuclear Information System (INIS)

Purpose: The temporomandibular dysfunction is a common pathology. It appears with many symptoms as: joint pain, mechanic disturbance, and loss of mouth motion. The Magnetic Resonance Image is the chose method to study these alterations. The purposes of this paper are to demonstrate according to sex, the distribution of temporomandibular dysfunction and to determinant the relationships between the disc dislocation and the degenerative disease of the junction. Material and Method: 215 patients were evaluated between January 1999 and August 2004. An Elscint MRI 2 Tesla machine was used with Spin-echo (T1 and T2) Fat-sat sequences, in coronal, axial and sagittal planes. The follow alterations were evaluated: dislocation, degenerative disease of articular surface, osteochondritis, discal perforation, and retrodiscal lesions. Results: 175 of all showed pathologic alterations in IRM examination. The other 40 patients were excluded due to present a normal (MRI) study. The patients were 146 females and 29 men. The most common dislocation site was the anterior. Performance of the IRM was useful in all the cases to demonstrate degenerative changes in the temporomandibular joint (TMJ). And was a very precise relationship between the dislocation and degenerative disease of the joint. Conclusion: the female patient is the most frequently affected by temporomandibular joint pathology. The IRM is the selection method to study the TMJ. The degenerative changes are responsible for joint dislocation without reduction. (author)

2006-01-01

154

Vegetables as a Source of Dietary Fiber to Prevent Degenerative Diseases  

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Full Text Available For long time vegetables were thought only as sources of several vitamins; however, it has been shown that vegetables contain other component, which is also important for maintaining body's health, i.e., dietary fiber. Dietary fiber is a group of polysaccharides oan other polymers, which cannot be digested by upper gastro-intestinal system of human. Dietary fiber can be grouped as soluble and insoluble dietary fiber, showing in different physiological effect. Soluble dietary fiber (SDF is effective in preventing cardiovascular disease, while insoluble dietary fiber (IDF can prevent the development of colon cancer, diverticulosis as well as obesity.Local vegetables found to contain high SDF (higher than 3,06% db are: watercress, green bean, carrot, eggplant, lettuce, broccoli, spinach, string bean, and aubergine; while which contain high IDF (higher than 40,60% db are: winged bean, watercress, chinese leaves, katuk leaves, lettuce, green bean, broccoli, carrot and spinach. Cooking (i.e. boiling, steaming and pan frying decrease the IDF content of vegetables, while their SDF content is not affected by cooking treatments.

Deddy Muchtadi

2001-04-01

155

Custom cerium oxide nanoparticles protect against a free radical mediated autoimmune degenerative disease in the brain.  

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Cerium oxide nanoparticles are potent antioxidants, based on their ability to either donate or receive electrons as they alternate between the +3 and +4 valence states. The dual oxidation state of ceria has made it an ideal catalyst in industrial applications, and more recently, nanoceria's efficacy in neutralizing biologically generated free radicals has been explored in biological applications. Here, we report the in vivo characteristics of custom-synthesized cerium oxide nanoparticles (CeNPs) in an animal model of immunological and free-radical mediated oxidative injury leading to neurodegenerative disease. The CeNPs are 2.9 nm in diameter, monodispersed and have a -23.5 mV zeta potential when stabilized with citrate/EDTA. This stabilizer coating resists being 'washed' off in physiological salt solutions, and the CeNPs remain monodispersed for long durations in high ionic strength saline. The plasma half-life of the CeNPs is ?4.0 h, far longer than previously described, stabilized ceria nanoparticles. When administered intravenously to mice, the CeNPs were well tolerated and taken up by the liver and spleen much less than previous nanoceria formulations. The CeNPs were also able to penetrate the brain, reduce reactive oxygen species levels, and alleviate clinical symptoms and motor deficits in mice with a murine model of multiple sclerosis. Thus, CeNPs may be useful in mitigating tissue damage arising from free radical accumulation in biological systems. PMID:24266731

Heckman, Karin L; DeCoteau, William; Estevez, Ana; Reed, Kenneth J; Costanzo, Wendi; Sanford, David; Leiter, James C; Clauss, Jennifer; Knapp, Kylie; Gomez, Carlos; Mullen, Patrick; Rathbun, Elle; Prime, Kelly; Marini, Jessica; Patchefsky, Jamie; Patchefsky, Arthur S; Hailstone, Richard K; Erlichman, Joseph S

2013-12-23

156

Anterior cervical fusion with polyetheretherketone (PEEK) cages in the treatment of degenerative disc disease. Preliminary observations in 36 consecutive cases with a minimum 12-month follow-up  

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STUDY DESIGN: Retrospective analysis of 36 cases of degenerative disc disease treated by interbody fusion with polyetheretherketone (PEEK) cages. OBJECTIVE: To determine the safety and efficiency of PEEK cages for anterior cervical fusion (ACF). SUMMARY OF BACKGROUND DATA: ACF with autologous bone has been reported since over 50 years ago. The recent development of cages housing materials inducing osteogenesis simplifies the technique of interbody fusion. The main purposes of bone substitutes...

Ducati, Alessandro

2006-01-01

157

Deciphering structural intermediates and genotoxic fibrillar aggregates of albumins: a molecular mechanism underlying for degenerative diseases.  

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The misfolding and aggregation of proteins is involved in some of the most prevalent neurodegenerative disorders. The importance of human serum albumin (HSA) stems from the fact that it is involved in bio-regulatory and transport phenomena. Here the effect of acetonitrile (ACN) on the conformational stability of HSA and by comparison, ovalbumin (OVA) has been evaluated in the presence and absence of NaCl. The results show the presence of significant amount of secondary structure in HSA at 70% ACN and in OVA at 50% ACN, as evident from far-UV Circular Dichroism (CD) and Attenuated Total Reflection Fourier transformed infra red spectroscopy (ATR-FTIR). Tryptophan and 8-Anilino-1-Naphthalene-Sulphonic acid (ANS) fluorescence indicate altered tryptophan environment and high ANS binding suggesting a compact "molten globule"-like conformation with enhanced exposure of hydrophobic surface area. However, in presence of NaCl no intermediate state was observed. Detection of aggregates in HSA and OVA was possible at 90% ACN. Aggregates possess extensive ?-sheet structure as revealed by far-UV CD and ATR-FTIR. These aggregates exhibit increase Thioflavin T (Th T) fluorescence with a red shift of Congo red (CR) absorption spectrum. X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM) analysis confirmed the presence of fibrillar aggregates. Single cell gel electrophoresis (SCGE) assay of these fibrillar aggregates showed the DNA damage resulting in cell necrosis confirming their genotoxic nature. Some proteins not related to any human disease form fibrils in vitro. In the present study ACN gives access to a model system to study the process of aggregation. PMID:23342075

Naeem, Aabgeena; Amani, Samreen

2013-01-01

158

Early clinical effects of the Dynesys system plus transfacet decompression through the Wiltse approach for the treatment of lumbar degenerative diseases  

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Background This study investigated early clinical effects of Dynesys system plus transfacet decompression through the Wiltse approach in treating lumbar degenerative diseases. Material/Methods 37 patients with lumbar degenerative disease were treated with the Dynesys system plus transfacet decompression through the Wiltse approach. Results Results showed that all patients healed from surgery without severe complications. The average follow-up time was 20 months (9–36 months). Visual Analogue Scale and Oswestry Disability Index scores decreased significantly after surgery and at the final follow-up. There was a significant difference in the height of the intervertebral space and intervertebral range of motion (ROM) at the stabilized segment, but no significant changes were seen at the adjacent segments. X-ray scans showed no instability, internal fixation loosening, breakage, or distortion in the follow-up. Conclusions The Dynesys system plus transfacet decompression through the Wiltse approach is a therapeutic option for mild lumbar degenerative disease. This method can retain the structure of the lumbar posterior complex and the motion of the fixed segment, reduce the incidence of low back pain, and decompress the nerve root.

Liu, Chao; Wang, Lei; Tian, Ji-wei

2014-01-01

159

Application of stable isotopic techniques in the prevention of degenerative diseases like obesity and NIDDM in developing societies  

International Nuclear Information System (INIS)

Economic development in developing societies characterized by industrialization, urbanization and globalization has seen the emergence of an epidemic of diet and life-style related chronic degenerative diseases. A research project has been initiated under the aegis of the International Atomic Energy Agency (IAEA), Vienna, Austria, under its Co-ordinated Research Programme (CRP) to promote the use of stable isotopic techniques to document the extent of the problem and to understand the determinants of this epidemic. The principal objectives of this CRP involving countries both in the North and the South are to define the magnitude of the problem of obesity and non-insulin Dependent diabetes mellitus (NIDDM) in developing countries, to identify the vulnerable groups at increased risk and to attempt to describe the metabolic and physiological mechanisms underlying this phenomenon. These comparative international studies of obesity and NIDDM are looking at the effects of childhood malnutrition (Brazil and socio-economic differentials (Mexico) on adult risk factors; the composition of the daily diet on obesity (Chile); levels of patterns of physical activity of older adults (China) as well as their influence on weight gain and obesity (Cuba, Nigeria); the impact of body composition and energy expenditure on the evolution frank diabetes from impaired glucose tolerance (Jamaica), and of body compositional changes and the role of inflammatory cytokines on impaired glucose tolerance (India). The last study conducted in New Zealand was aimed at comparing the energy expenditures of Maori (Pacific Island) with New Zealanders of European descent. The findings of the CRP of the MEA in this area carried out in several countries are presented in this article. (author)

2001-06-25

160

Clinical and Radiological Comparison of Femur and Fibular Allografts for the Treatment of Cervical Degenerative Disc Diseases  

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Objective This consecutive retrospective study was designed to analyze and to compare the efficacy and outcomes of anterior cervical discectomy and fusion (ACDF) using a fibular and femur allograft with anterior cervical plating. Methods A total of 88 consecutive patients suffering from cervical degenerative disc disease (DDD) who were treated with ACDF from September 2007 to August 2010 were enrolled in this study. Thirty-seven patients (58 segments) underwent anterior interbody fusion with a femur allograft, and 51 patients (64 segments) were treated with a fibular allograft. The mean follow-up period was 16.0 (range, 12-25) months in the femur group and 19.5 (range, 14-39) months in the fibular group. Cage fracture and breakage, subsidence rate, fusion rate, segmental angle and height and disc height were assessed by using radiography. Clinical outcomes were assessed using a visual analog scale and neck disability index. Results At 12 months postoperatively, cage fracture and breakage had occurred in 3.4% (2/58) and 7.4% (4/58) of the patients in the femur group, respectively, and 21.9% (14/64) and 31.3% (20/64) of the patients in the fibular group, respectively (p<0.05). Subsidence was noted in 43.1% (25/58) of the femur group and in 50.5% (32/64) of the fibular group. No difference in improvements in the clinical outcome between the two groups was observed. Conclusion The femur allograft showed good results in subsidence and radiologic parameters, and sustained the original cage shape more effectively than the fibular allograft. The present study suggests that the femur allograft may be a good choice as a fusion substitute for the treatment of cervical DDD.

Oh, Hyeong-Seok; Shim, Chan Shik; Lee, Sang-Ho

2013-01-01

 
 
 
 
161

Degenerative Suspensory Ligament Desmitis – A New Reality  

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Full Text Available Degenerative suspensory ligament desmitis (DSLD is a chronic, debilitating disease occurring primarily in Peruvian Pasos and Peruvian Paso crosses. However, many other breeds are afflicted as well. DSLD is characterized by a slowly progressing bilateral or quadrilateral lameness. Typically, the owner does not recall any trauma or performance related injury. Fetlock effusion, static and dynamic hyperextension and degenerative joint disease are hallmarks on physical examination. Ultrasonography of affected ligaments reveals diffuse loss of echogenicity, and an irregular fiber pattern. Though until recently DSLD was considered a collagen disorder strictly limited to suspensory ligaments (SLs, our data show that it is a systemic disease involving tissues with high content of collagen. We have identified abnormal accumulations of proteoglycans not only in the SLs, but also in the superficial and deep digital flexor tendons, patellar and nuchal ligaments, aorta, coronary arteries and sclerae of DSLD-affected horses. Our most recent data point to the presence of an abnormal form of decorin in these proteoglycan deposits. This decorin also exhibited altered biological activity. Treatment for DSLD-affected horses is empirical and directed at minimizing musculoskeletal pain and providing support for the suspensory apparatus. Restricted exercise, supportive bandages and nonsteroidal anti-inflammatory drugs provide some, but usually only temporary relief. Unfortunately, unrelenting pain, severe lameness and suffering require all too often humane euthanasia.

Jaroslava Halper*, Ahrar Khan1 and P. O. Eric Mueller2

2011-01-01

162

Degenerative lumbosacral stenosis in dogs  

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Degenerative lumbosacral stenosis (DLS) is now recognized as a significant cause of caudal lumbar pain and pelvic limb lameness in dogs. The condition includes lumbosacral intervertebral disc degeneration and protrusion, spondylosis deformans, sclerosis of the vertebral end plates, osteoarthrosis of articular facets, ventral sacral subluxation, and hypertrophy of the ligamentum flavum and joint capsules. The clinical signs are caudal lumbar pain, pelvic limb lameness, reluctance to jump, rise...

2007-01-01

163

Canine degenerative myelopathy.  

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Canine degenerative myelopathy (DM) is an adult-onset fatal neurodegenerative disease that occurs in many breeds. The initial upper motor neuron spastic paraparesis and general proprioceptive ataxia in the pelvic limbs progress to a flaccid lower motor neuron tetraparesis. Recently, a missense mutation in the superoxide dismutase 1 (SOD1) gene was found to be a risk factor for DM, suggesting that DM is similar to some forms of human amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). This article reviews the current knowledge of canine DM with regard to its signalment, clinical spectrum, diagnostic approach, and treatment. The implications of the SOD1 mutation on both diseases are discussed, comparing pathogenic mechanisms while conveying perspectives to translational medicine. PMID:20732599

Coates, Joan R; Wininger, Fred A

2010-09-01

164

Sacroiliac joint pain: burden of disease  

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Full Text Available Daniel Cher,1 David Polly,2 Sigurd Berven31SI-BONE, Inc., San Jose, CA, USA; 2Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN, USA; 3Department of Orthopedic Surgery, University of California San Francisco, San Francisco, CA, USAObjectives: The sacroiliac joint (SIJ is an important and significant cause of low back pain. We sought to quantify the burden of disease attributable to the SIJ.Methods: The authors compared EuroQol 5D (EQ-5D and Short Form (SF-36-based health state utility values derived from the preoperative evaluation of patients with chronic SIJ pain participating in two prospective clinical trials of minimally invasive SIJ fusion versus patients participating in a nationally representative USA cross-sectional survey (National Health Measurement Study [NHMS]. Comparative analyses controlled for age, sex, and oversampling in NHMS. A utility percentile for each SIJ subject was calculated using NHMS as a reference cohort. Finally, SIJ health state utilities were compared with utilities for common medical conditions that were published in a national utility registry.Results: SIJ patients (number [n]=198 had mean SF-6D and EQ-5D utility scores of 0.51 and 0.44, respectively. Values were significantly depressed (0.28 points for the SF-6D utility score and 0.43 points for EQ-5D; both P<0.0001 compared to NHMS controls. SIJ patients were in the lowest deciles for utility compared to the NHMS controls. The SIJ utility values were worse than those of many common, major medical conditions, and similar to those of other common preoperative orthopedic conditions.Conclusion: Patients with SIJ pain presenting for minimally invasive surgical care have marked impairment in quality of life that is worse than in many chronic health conditions, and this is similar to other orthopedic conditions that are commonly treated surgically. SIJ utility values are in the lowest two deciles when compared to control populations.Keywords: sacroiliac joint fusion, chronic lower back pain, quality of life, utility assessment, comparative assessments

Cher D

2014-04-01

165

Primary joint disease in the shoulder of the beagle dog  

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Shoulder joints of 149 beagle dogs, whose ages were over 8 years at the time of death, were examined to document primary joint disease. Clinical histories of the dogs suggested no underlying causes, i.e. no evidence of osteochondrosis, trauma or joint infection. Radiographic examinations revealed normally developing shoulders in the first years of their lives. Radiographic changes were progressive with age. Bilateral involvement was common. The changes consisted of osteophyte formation on the caudal aspect of the humeral head and glenoid. Postmortem findings included: subchondral bone sclerosis (thin-section radiographs), cartilage wearing, joint capsule thickening, and pannus formation. The authors believe that the changes occurring in the shoulder joints are those of primary joint disease. 12 references

1985-11-01

166

Evaluation and characterization of knee joint instability in ACL deficient patients  

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Osteoarthritis is a degenerative joint disease that is characterized by structural and cellular degradation of the cartilage, which is thought to be induced by pathological loading patterns as well as joint instability. The disease naturally affects several joints of the human body; however, the incidence of osteoarthritis is known to be higher in the knee joint than in other joints. The early detection of osteoarthritic disease onset is not yet possible. However, the quantification of knee j...

Boeth, Heide

2013-01-01

167

Clinical and radiologic comparison of dynamic cervical implant arthroplasty versus anterior cervical discectomy and fusion for the treatment of cervical degenerative disc disease.  

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This study compared the clinical and radiological outcomes of dynamic cervical implant (DCI; Scient'x, Villers-Bretonneux, France) arthroplasty versus anterior cervical discectomy and fusion (ACDF) for the treatment of cervical degenerative disc disease. This prospective cohort study enrolled patients with single-level cervical degenerative disc disease who underwent DCI arthroplasty or ACDF between September 2009 and June 2011. Patients were followed up for more than 2years. Clinical evaluation included the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), Neck Disability Index (NDI), Japan Orthopedic Association (JOA) score, and visual analog scale (VAS) scores for neck and arm pain. Radiological assessments included segmental range of motion (ROM), overall ROM (C2-C7), disc height (DHI), and changes in adjacent disc spaces. The VAS, SF-36, JOA, and NDI scores improved significantly after surgery in both the DCI and ACDF groups. The VAS, JOA, and SF-36 scores were not significantly different between the DCI and ACDF groups at the final follow-up. The segmental ROM at the treated level and overall ROM increased significantly after surgery in the DCI group, but the ROM in the adjacent cephalad and caudal segments did not change significantly. The mean DHI at the treated level was significantly restored after surgery in both groups. Five patients (12.8%) in the DCI group showed new signs of adjacent segment degeneration. These results indicate that DCI is an effective, reliable, and safe procedure for the treatment of cervical degenerative disc disease. However, there is no definitive evidence that DCI arthroplasty has better intermediate-term results than ACDF. PMID:24411326

Li, Zhonghai; Yu, Shunzhi; Zhao, Yantao; Hou, Shuxun; Fu, Qiang; Li, Fengning; Hou, Tiesheng; Zhong, Hongbin

2014-06-01

168

Early results and review of the literature of a novel hybrid surgical technique combining cervical arthrodesis and disc arthroplasty for treating multilevel degenerative disc disease: opposite or complementary techniques?  

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We report the clinical and radiological results on the safety and efficacy of an unusual surgical strategy coupling anterior cervical discectomy and fusion and total disc replacement in a single-stage procedure, in patients with symptomatic, multilevel cervical degenerative disc disease (DDD). The proposed hybrid, single-stage, fusion–nonfusion technique aims either at restoring or maintaining motion where appropriate or favouring bony fusion when indicated by degenerative changes. Twenty-f...

Barbagallo, Giuseppe M. V.; Assietti, Roberto; Corbino, Leonardo; Olindo, Giuseppe; Foti, Pietro V.; Russo, Vittorio; Albanese, Vincenzo

2009-01-01

169

Quantification of degenerative arthropathies  

International Nuclear Information System (INIS)

Osteoarthritis as well as rheumatoid arthritis lead to chronical progessive destruction of diseased joints. As aggressive new treatments need to be evaluated, plenty of (semi-)quantitative methods for the radiological joint evaluation had been developed. They lack sufficient reproducibility due to their low objectivity. Modern approaches of computerassisted radiological quantification should increase the reproducibility and efficiency of radiological scoring. Automatically calculated, computerassisted measurements of joint space, cartilage- and synovial volume, periarticular assessment of bone mineral density and quantitative analysis of the subchondral plate will have major impact on the radiological routine of the future. (orig.)

2000-12-01

170

New aspects of radionuclide therapy of bone and joint diseases  

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Whereas in developing countries P-32 is widely used for radionuclide therapy of painful bone metastases, in Europe three radionuclides or radiopharmaceutical agents are available for pain palliation: Sr-89, Sm-153-EDTMP, and Re-186-HEDP. Radionuclide therapy for pain palliation is indicated for bone pain due to metastatic malignancy that has involved multiple skeletal sites and has evoked an osteoblastic response on bone scintigraphy. Response rates of about 70-80% in patients with breast or prostate cancer is reported in the literature, less in metastatic lesions of other primary malignancies. Sm-153-EDTMP may also be used for curative treatment of primary bone tumours or their metastases. Radiosynovectomy as therapeutic procedure or rheumatoid arthritis, other inflammatory joint diseases, persistent synovial perfusion, and other joint diseases is widely used. Using Y-90 for the knee joint, Re-186 for middle sized joints, and Er-169 for small joints an improvement of symptoms may be observed in about 70-80%. (author)

2001-06-01

171

STUDY ON THE LIMITS AND POSSIBILITIES OF THE HCP “DESOSPITALIZAR” IN PATIENTS WITH CHRONIC DEGENERATIVE DISEASES IN THE REGIONAL HEALTH OF PARANOÁ.  

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Full Text Available This research project intends to evaluate the possibilities, challenges and impacts of health actions made by Home Care Program (PID, effected at the Regional Center for Home Care (NRAD, about the vacancy of hospital beds occupied by people from Paranoá's Regional. It is a descriptive study where was applied an validated instrument with title, Classification System for Patients: construction and validation of an instrument. (PERROCA. M.G.; GAIDZINSKI, R. R., et al, 1998. The data collection period was between January and March 2013 in Paranoá's NRAD. Were analyzed 29 patients with chronic degenerative diseases who are in home care. On scores of 29 patients admitted in this program, it was found that 13 patients require minimal care (44.82% and 13 patients, equally, require intermediate care (44.82%. So, it is concluded that the obtained data in this research indicates that the limits and possibilities of the Regional Center for Home Care Program (NRAD in "desospitalizar" (take out of the hospital patients with chronic degenerative diseases at Paranoá's Regional Health are favoring patients admitted with scores below the pre-established ones, according to criteria of the program through the scale used for intermediate care.

Camila Reis Santana

2014-02-01

172

3D MRI of the cervical spine: low flip angle FISP vs. Gd-DTPA TurboFLASH in degenerative disk disease.  

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The authors undertook this study to compare bright and dark CSF three-dimensional (3D) gradient-echo (GE) MR techniques to answer the following questions: Could a single Gd-DTPA enhanced T1-weighted GE volume sequence (with multiplanar reformats) be diagnostically equivalent for degenerative cervical disk disease to a standard sequence consisting of sagittal T1-weighted spin echo and axial low flip angle volume GE images (with reformatted images)? Does performing oblique coronal reformats perpendicular to the course of exiting cervical nerve roots improve diagnostic confidence over axial images alone? Thirty-one consecutive patients received a "routine" MR examination consisting of a sagittal T1-weighted spin echo and axial low flip angle volume sequence (FISP) [(35/7/5), 64 slices, 2 mm slice thickness, 192 x 256 matrix, 7.2 min]. Each patient was then given 0.1 mmol/kg Gd-DTPA intravenously, and reimaged with a T1-weighted volume GE sequence [(13/6/12), acquired as 128-1.2 mm coronal partitions, 192 x 256 matrix, 5.5 min]. Sequences were reconstructed on the standard diagnostic console in 1 mm increments. Sets of examinations (routine vs T1-weighted volume) were independently interpreted by three neuroradiologists for location, type, and severity of extradural degenerative disease. There was no strong or consistent trend for increased detection of disease by one imaging sequence over the other. For lateral disk disease, only 3% of the observations were in discordance. For disk disease, there was close agreement in the severity scores. All readers indicated that additional information was provided by the reformatted images more frequently with TurboFLASH (fast low angle shot) than with FISP. All readers indicated that increased confidence was provided by the reformatted images more frequently with TurboFLASH than with FISP. A single 3D contrast-enhanced TurboFLASH sequence is diagnostically equivalent to a set of two-dimensional T1-weighted sagittal spin echo and 3D axial low flip angle sequences for assessing the location and degree of cervical extradural degenerative disease. A screening examination of the cervical spine could be performed with a single contrast-enhanced 5.2 min study, and then relying on computer postprocessing to provide additional imaging planes. PMID:8419435

Ross, J S; Ruggieri, P M; Glicklich, M; Obuchowski, N; Dillinger, J; Masaryk, T J; Qu, Y; Modic, M T

1993-01-01

173

Treatment of Nongout Joint Deposition Diseases: An Update  

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This update develops the actual therapeutic options in the management of the joint involvement of calcium pyrophosphate deposition disease (CPPD), basic calcium phosphate (BCP) deposition disease, hemochromatosis (HH), ochronosis, oxalosis, and Wilson's disease. Conventional pharmaceutical treatment provides benefits for most diseases. Anti-interleukine-1 (IL-1) treatment could provide similar results in CPPD than in gout flares. There is only limited evidence about the efficacy of preventive long-term colchicine intake, methotrexate, and hydroxychloroquine in chronic CPPD. Needle aspiration and lavage have satisfactory short and midterm results in BCP. Extracorporeal shockwave therapy has also proved its efficacy for high-doses regimes. Phlebotomy does not seem to have shown real efficacy on joint involvement in HH so far. Iron chelators' effects have not been assessed on joint involvement either, while IL-1 blockade may prove useful. NSAIDs have limited efficacy on joint involvement of oxalosis, while colchicine and steroids have not been assessed either. The use of nitisinone for ochronotic arthropathy is still much debated, but it could provide beneficial effects on joint involvement. The effects of copper chelators have not been assessed either in the joint involvement of Wilson's disease. NSAIDs should be avoided because of the liver affection they may worsen.

Richette, Pascal; Flipo, Rene-Marc

2014-01-01

174

Treatment of nongout joint deposition diseases: an update.  

Science.gov (United States)

This update develops the actual therapeutic options in the management of the joint involvement of calcium pyrophosphate deposition disease (CPPD), basic calcium phosphate (BCP) deposition disease, hemochromatosis (HH), ochronosis, oxalosis, and Wilson's disease. Conventional pharmaceutical treatment provides benefits for most diseases. Anti-interleukine-1 (IL-1) treatment could provide similar results in CPPD than in gout flares. There is only limited evidence about the efficacy of preventive long-term colchicine intake, methotrexate, and hydroxychloroquine in chronic CPPD. Needle aspiration and lavage have satisfactory short and midterm results in BCP. Extracorporeal shockwave therapy has also proved its efficacy for high-doses regimes. Phlebotomy does not seem to have shown real efficacy on joint involvement in HH so far. Iron chelators' effects have not been assessed on joint involvement either, while IL-1 blockade may prove useful. NSAIDs have limited efficacy on joint involvement of oxalosis, while colchicine and steroids have not been assessed either. The use of nitisinone for ochronotic arthropathy is still much debated, but it could provide beneficial effects on joint involvement. The effects of copper chelators have not been assessed either in the joint involvement of Wilson's disease. NSAIDs should be avoided because of the liver affection they may worsen. PMID:24895535

Pascart, Tristan; Richette, Pascal; Flipo, René-Marc

2014-01-01

175

Knee joint replacement - series (image)  

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The knee is a complex joint. It contains the distal end of the femur (the femoral condyles) and the ... The most common cause of knee damage that leads to knee replacement ... is a degenerative disease of the bones of the knee. It causes ...

176

CT evaluation of chronic hip joint diseases: avascular necrosis vs. osteoarthritis  

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Computed tomography (CT) of the hip was done on 37 patients those who have been suffered from chronic hip joint pain. There were 18 patients of avascular necrosis of hip (AVN), 67% of whom were affected bilaterally, 15 patients of degenerative arthritis (DA), 33% bilaterally; one patient of tuberculous arthritis, rheumatoid arthritis and traumatic arthritis respectively. Comparison of the staging by means of the CT and plain film showed good correlation between the two methods. The CT findings of the AVN and OA were also compared; crescent sign or fissure, loss of congruity, and loss or change of normal asterisk sign were more commonly seen in AVN. Acetabular change especially associated cystic appearance, osteophytes formation and joint narrowing were more frequent in OA. CT showed primary and secondary change of AVN and OA more clearly without confusion than plain film. We think that CT can be helpful in evaluation and understanding of each disease process and differentiation of the two lesions in difficult cases.

1988-12-01

177

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 11: Interbody techniques for lumbar fusion.  

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Interbody fusion techniques have been promoted as an adjunct to lumbar fusion procedures in an effort to enhance fusion rates and potentially improve clinical outcome. The medical evidence continues to suggest that interbody techniques are associated with higher fusion rates compared with posterolateral lumbar fusion (PLF) in patients with degenerative spondylolisthesis who demonstrate preoperative instability. There is no conclusive evidence demonstrating improved clinical or radiographic outcomes based on the different interbody fusion techniques. The addition of a PLF when posterior or anterior interbody lumbar fusion is performed remains an option, although due to increased cost and complications, it is not recommended. No substantial clinical benefit has been demonstrated when a PLF is included with an interbody fusion. For lumbar degenerative disc disease without instability, there is moderate evidence that the standalone anterior lumbar interbody fusion (ALIF) has better clinical outcomes than the ALIF plus instrumented, open PLF. With regard to type of interbody spacer used, frozen allograft is associated with lower pseudarthrosis rates compared with freeze-dried allograft; however, this was not associated with a difference in clinical outcome. PMID:24980588

Mummaneni, Praveen V; Dhall, Sanjay S; Eck, Jason C; Groff, Michael W; Ghogawala, Zoher; Watters, William C; Dailey, Andrew T; Resnick, Daniel K; Choudhri, Tanvir F; Sharan, Alok; Wang, Jeffrey C; Kaiser, Michael G

2014-07-01

178

Computed tomography for diseases of the knee joint  

International Nuclear Information System (INIS)

CT was performed on 126 knee joints of 63 patients with diseases of the knee joint, and the results were discussed. CT was useful to know changes in the patella, because CT images of the patella-femoral joint could visualize the position of the joint minutely and the congruence angle of the joint could be measured on CT images taken at extension position. CT images of diseases with rupture of cartilage such as steroid arthritis could visualize the rupture as the defect. Therefore, CT was useful for the following invasive therapy. In osteoarthritis of the knee joint, the progress of osteosclerosis could be observed by measuring subcartilaginous trabeculae on sequential CT images. Transaxial image of meniscus injuries by CT could visualize the meniscus. Clear CT image of crucial ligament could be obtained by air injection quadricepts femoris atrophy could be observed quantitatively by CT and furthermore CT could clearly visualize folds of synovial membrane within the patella. CT made it possible to make a diagnosis of knee joint disorders. (Tsunoda, M.)

1980-01-01

179

Comparison of degree of postoperative muscle damage between MIS-TLIF- and PLIF treatment for single-level degenerative lumbar disease  

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Full Text Available Objective?To compare the postoperative muscle damage after either posterior lumbar interbody fusion (PLIF or minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF with the aid of X-Tube system in patients with singlelevel degenerative lumbar spinal disease. Methods?The clinical data of 52 patients (males 28, females 24, aged 54.3±7.8 years with single-level degenerative lumbar spinal disease undergoing MIS-TLIF assisted by the X-Tube system from Oct 2010 to Sep 2011 was analyzed retrospectively. The operative time, intraoperative blood loss, postoperative drainage volume, postoperative bedtime, and serum creatine kinase (CK level 1 day before surgery and 1, 3 and 5 days after surgery were recorded and compared with those of 38 patients (males 20, females 18, aged 51.6±8.6 years with the same disease undergoing conventional open PLIF during the corresponding period. The back pain visual analogue score (VAS, Oswestry disability index (ODI score and imaging examination were performed before operation, after operation and during follow-up duration for each patient. Results?There was no significant difference in the gender, age, clinical diagnosis, lesion location, preoperative CK level, VAS and ODI scores between the two groups (P>0.05. The operative time was longer in MIS-TLIF group than in PLIF group (P0.05. Radiological followup observation revealed good fusion 6 months after operation in all the patients. Conclusion?The X-Tube-assisted MIS-TLIF has several advantages over conventional open PLIF, such as less intraoperative blood loss, milder muscle damage, and lighter back pain. DOI: 10.11855/j.issn.0577-7402.2013.12.04

Liang ZHOU

2014-01-01

180

[Expert assessment of noise-induced hearing loss with special reference to differentiation between noise-induced damage and other degenerative diseases of the ear].  

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In patients with noise-induced hearing loss (NIHL) who also suffer from other degenerative diseases of the ear, a medicolegal opinion must be based on detailed knowledge of the pathophysiology of Corti's organ and on audiometric findings. Only with this special knowledge is it possible to differentiate accurately between NIHL and other types of hearing loss. At the same time, interactions must be considered between endogenous dysfunctions of the hair cells and their sensitivity to overload by severe noise. On the other hand, the diagnosis of NIHL is not valid when there were uncertainties with respect to the type of hearing dysfunction or the risk of noise at the place of work. These difficulties also apply to the estimation of the individual disability from NIHL when associated with other types of hearing loss. PMID:1577628

Plath, P

1992-03-01

 
 
 
 
181

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 2: Assessment of functional outcome following lumbar fusion.  

Science.gov (United States)

Assessment of functional patient-reported outcome following lumbar spinal fusion continues to be essential for comparing the effectiveness of different treatments for patients presenting with degenerative disease of the lumbar spine. When assessing functional outcome in patients being treated with lumbar spinal fusion, a reliable, valid, and responsive outcomes instrument such as the Oswestry Disability Index should be used. The SF-36 and the SF-12 have emerged as dominant measures of general health-related quality of life. Research has established the minimum clinically important difference for major functional outcomes measures, and this should be considered when assessing clinical outcome. The results of recent studies suggest that a patient's pretreatment psychological state is a major independent variable that affects the ability to detect change in functional outcome. PMID:24980579

Ghogawala, Zoher; Resnick, Daniel K; Watters, William C; Mummaneni, Praveen V; Dailey, Andrew T; Choudhri, Tanvir F; Eck, Jason C; Sharan, Alok; Groff, Michael W; Wang, Jeffrey C; Dhall, Sanjay S; Kaiser, Michael G

2014-07-01

182

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 5: Correlation between radiographic outcome and function.  

Science.gov (United States)

In an effort to diminish pain or progressive instability, due to either the pathological process or as a result of surgical decompression, one of the primary goals of a fusion procedure is to achieve a solid arthrodesis. Assuming that pain and disability result from lost mechanical integrity of the spine, the objective of a fusion across an unstable segment is to eliminate pathological motion and improve clinical outcome. However, conclusive evidence of this correlation, between successful fusion and clinical outcome, remains elusive, and thus the necessity of documenting successful arthrodesis through radiographic analysis remains debatable. Although a definitive cause and effect relationship has not been demonstrated, there is moderate evidence that demonstrates a positive association between radiographic presence of fusion and improved clinical outcome. Due to this growing body of literature, it is recommended that strategies intended to enhance the potential for radiographic fusion are considered when performing a lumbar arthrodesis for degenerative spine disease. PMID:24980582

Dhall, Sanjay S; Choudhri, Tanvir F; Eck, Jason C; Groff, Michael W; Ghogawala, Zoher; Watters, William C; Dailey, Andrew T; Resnick, Daniel K; Sharan, Alok; Mummaneni, Praveen V; Wang, Jeffrey C; Kaiser, Michael G

2014-07-01

183

Clinical study to evaluate the safety and effectiveness of the Aesculap Activ-L™ artificial disc in the treatment of degenerative disc disease  

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Full Text Available Abstract Background The objective of this clinical study is to evaluate the safety and effectiveness of the Activ-L Artificial Disc for treatment of single-level degenerative disc disease of the lumbar spine in patients who have been unresponsive to at least six months of prior conservative care. The hypothesis of the study is that the Activ-L Disc is non-inferior to the control (the Charité® Artificial Disc [DePuy Spine] or ProDisc-L® Total Disc Replacement [Synthes Spine] with respect to the rate of individual subject success at 24 months. Individual subject success is a composite of effectiveness and safety. Methods/Design The study proposed is a prospective, randomized, single-masked, controlled, multi-center clinical trial consisting of an estimated 414 subjects with single-level DDD of the lumbar spine (L4/L5, or L5/S1 who have failed to improve with conservative treatment for at least six months prior to enrollment. After enrollment, subjects will be randomized in a 2:1 ratio to either the Activ-L Disc (investigational device or the control (Charité or ProDisc-L. Radiographic endpoints will be evaluated by an independent reviewer at an imaging core laboratory. Each subject will be followed for 5 years post-treatment. Discussion The safety and effectiveness of the Activ-L Artificial Disc for treatment of single-level degenerative disc disease of the lumbar spine will be equivalent to Charité® Artificial Disc [DePuy Spine] or ProDisc-L® Total Disc Replacement [Synthes Spine] at 24 months. Trial Registration Current Controlled Trials NCT00589797.

Mo Fred F

2010-04-01

184

Temporomandibular joint dysfunction in various rheumatic diseases  

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Full Text Available Temporomandibular disorder (TMD is an inclusive term in which those conditions disturbing the masticatory function are embraced. It has been estimated that 33% of the population have signs of TMD, but less than 5% of the population will require treatment. The objective of this study was to measure the frequency of TMD in rheumatoid arthritis (RA, osteoarthrosis (OA, ankylosing spondylitis (AS and systemic lupus erythematosus, and to define the limitations in everyday’s life that patients perceive when present. A six-month survey of consecutive outpatients in a rheumatology clinic in a teaching hospital in Mexico was carried out. We defined TMD as: 1 the presence of pain; 2 difficulty on mouth opening, chewing or speaking; 3 the presence of non-harmonic movements of the temporomaxilar joints. All three characteristics had to be present. Z test was used to define differences between proportions. We present the results of 171 patients. Overall, 50 patients had TMD according to our operational definition (29.24%. Up to 76% of the sample had symptoms associated with the condition. TMD is more frequent in OA and in AS (29.24% vs 38% OA, P=0.009; 39% AS; P=0.005. We found no association between the severity of TMD and the request for specific attention for the discomfort produced by the condition. Only 8 of 50 (16% patients with TMD had requested medical help for their symptoms, and they were not the most severe cases. TMD is more frequent in RA and OA. Although it may produce severe impairment, patients seem to adapt easily.

F.J. Aceves-Avila

2013-07-01

185

Temporomandibular joint dysfunction in various rheumatic diseases.  

Science.gov (United States)

Temporomandibular disorder (TMD) is an inclusive term in which those conditions disturbing the masticatory function are embraced. It has been estimated that 33% of the population have signs of TMD, but less than 5% of the population will require treatment. The objective of this study was to measure the frequency of TMD in rheumatoid arthritis (RA), osteoarthrosis (OA), ankylosing spondylitis (AS) and systemic lupus erythematosus, and to define the limitations in everyday's life that patients perceive when present. A six-month survey of consecutive outpatients in a rheumatology clinic in a teaching hospital in Mexico was carried out. We defined TMD as: 1) the presence of pain; 2) difficulty on mouth opening, chewing or speaking; 3) the presence of non-harmonic movements of the temporomaxilar joints. All three characteristics had to be present. Z test was used to define differences between proportions. We present the results of 171 patients. Overall, 50 patients had TMD according to our operational definition (29.24%). Up to 76% of the sample had symptoms associated with the condition. TMD is more frequent in OA and in AS (29.24% vs 38% OA, P=0.009; 39% AS; P=0.005). We found no association between the severity of TMD and the request for specific attention for the discomfort produced by the condition. Only 8 of 50 (16%) patients with TMD had requested medical help for their symptoms, and they were not the most severe cases. TMD is more frequent in RA and OA. Although it may produce severe impairment, patients seem to adapt easily. PMID:23884028

Aceves-Avila, F J; Chávez-López, M; Chavira-González, J R; Ramos-Remus, C

2013-01-01

186

Quantitative assessment of bone scintigraphy in the hip joint disease  

International Nuclear Information System (INIS)

Quantitative assessment of bone scintigraphy was performed in fifty-six patients with hip joint disease including femoral neck fracture, aseptic necrosis of the femoral head, traumatic dislocation of the hip, Perthes disease, and transient synovitis of the hip. In the static study, bone scintigraphy was obtained 3 hours after injection of sup(99m)Tc-MDP by gamma camera equipped with a computer and uptake ratios were calculated. In the dynamic study, bone scintigraphy was performed in one, 3 and 5 hours after injection of radionuclide. Femoral head uptake ratio was markedly decreased in osteonecrosis following femoral neck fracture and characteristically increased in aseptic necrosis of the femoral head but prolonged retention of sup(99m)Tc-MDP could be observed. Uptake ratios of epiphysis were decreased in Perthes disease but normal in transient synovitis of the hip. Static and dynamic study of bone scintigraphy may be useful for early diagnosis and treatment in the hip joint disease. (author)

1985-01-01

187

Radiotherapy of degenerative joint disorders. Indication, technique and clinical results; Radiotherapie bei schmerzhaften degenerativ-entzuendlichen Gelenkerkrankungen. Indikation, Technik und klinische Ergebnisse  

Energy Technology Data Exchange (ETDEWEB)

From 1984 to 1994, 85 patients with painful osteoarthritis were treated. The mean follow-up was 4 (1 to 10) years. Seventy-three patients (103 joints) were available for long-term analysis: 17 patients (27 joints) with omarthrosis, 19 (20 joints) with rhizarthrosis, 31 (49 joints) with osteoarthritis of the knee and 6 patients (7 joints) with osteoarthritis of the hip. All patients were intensively pretreated over long time. Mean symptom duration prior to radiotherapy was 4 (1 to 10) years. Orthovoltage or linac photons were applied using some technical modifications depending upon the joint. Two radiotherapy series (6 x 1 Gy, total dose: 12 Gy, 3 weekly fractions) were prescribed. The interval between the 2 series was 6 weeks. The subjective pain profil was assessed prior to and 6 months after radiotherapy and at last follow-up. Forty-six (63%) patients (64 joints) achieved a reduction of pain symptoms; 16 of those had a `major pain relief` and 14 `complete pain relief`. Large joints - knee and hip - responded better (64% each) than the rhizarthrosis (53%). All pain categories and grades and their combined pain score were significantly reduced. The pain reduction was mostly pronounced for the symptom `pain at rest`. The orthopedic score correlated well with the subjective response of the patients. The thumb score improved in 11 (57%) joints, the shoulder score of Constant and Murley in 16 (59%), the Japonese knee score of Sasaki et al. in 33 (67%), the hip score of Harris in 5 (71%) joints. Only 9 of 19 patients which were treated to avoid surgery, had to be operated, and 3 of those received a total arthroplasty of the hip or knee. In multivariate analysis for the endpoint `complete` or `major pain relief` only the criterion `symptom duration {>=}2 years prior to radiotherapy` was an independent negative prognostic parameter. (orig./MG) [Deutsch] Von 1984 bis 1994 wurden 85 Patienten wegen schmerzhaft arthrotischer Gelenkerkrankungen bestrahlt. 73 Patienten (103 Gelenke) konnten langfristig untersucht werden, 17 Patienten mit Omarthrose (27 Gelenke), 19 mit Rhizarthrose (20 Gelenke), 31 mit Gonarthrose (49 Gelenke) und sechs Patienten mit Koxarthrose (sieben Gelenke). Die Patienten waren lange und intensiv vorbehandelt mit einer mittleren Symptomdauer von vier Jahren. Die Strahlentherapie erfolgte je nach Gelenk mit geringen technischen Unterschieden in zwei Serien (6 x 0,5 bzw. 1 Gy pro Serie in drei Fraktionen pro Woche). Die zweite Serie erfolgte sechs Wochen nach der ersten. Die mittlere Nachbeobachtungszeit betrug vier (ein bis zehn) Jahre. Vor Radiotherapie, sechs Monate danach und zum aktuellen Zeitpunkt wurde das Schmerzprofil beurteilt. 46 (63%) Patienten (64 Gelenke) sprachen auf die Therapie an; 16 dieser Patienten waren `wesentlich gebessert`, 14 `beschwerdefrei`, Knie und Schulter sprachen besser an (je 64%) als die Rhizarthrose (53%). Alle Schmerzkategorien und -grade und deren Summenscore waren ruecklaeufig. Der staerkste Rueckgang trat bei `Ruheschmerzen` ein. Alle orthopaedischen Scores korrelierten gut mit den subjektiven Angaben der Patienten. Der Daumenscore besserte sich bei elf Faellen (57%), der Schulter-Score nach Constant et al. bei 16 (59%), der Knie-Score nach Sasaki et al. bei 33 (67%), der Hueft-Score nach Harris bei fuenf (71%). 9/19 Faelle, die zur Vermeidung der Operation bestrahlt wurden, mussten operiert werden, drei davon mit Totalendoprothese. In multivariater Analyse fuer das Zielkriterium `komplette Beschwerdefreiheit` bzw. `wesentliche Besserung` der Beschwerden war die lange Symtomdauer einziger Parameter mit negativer prognostischer Bedeutung. (orig./MG)

Keilholz, L.; Sauer, R. [Erlangen-Nuernberg Univ. (Germany). Strahlentherapeutische Klinik und Poliklinik; Seegenschmiedt, M.H. [Erlangen-Nuernberg Univ. (Germany). Strahlentherapeutische Klinik und Poliklinik]|[Alfred-Krupp-Krankenhaus, Essen (Germany). Klinik fuer Strahlentherapie und Radioonkologie

1998-05-01

188

The joint capsule: structure, composition, ageing and disease.  

Science.gov (United States)

The joint capsule is vital to the function of synovial joints. It seals the joint space, provides passive stability by limiting movements, provides active stability via its proprioceptive nerve endings and may form articular surfaces for the joint. It is a dense fibrous connective tissue that is attached to the bones via specialised attachment zones and forms a sleeve around the joint. It varies in thickness according to the stresses to which it is subject, is locally thickened to form capsular ligaments, and may also incorporate tendons. The capsule is often injured, leading to laxity, constriction and/or adhesion to surrounding structures. It is also important in rheumatic disease, including rheumatoid arthritis and osteoarthritis, crystal deposition disorders, bony spur formation and ankylosing spondylitis. This article concentrates on the specialised structures of the capsule--where capsular tissues attach to bone or form part of the articulation of the joint. It focuses on 2 joints: the rat knee and the proximal interphalangeal (PIP) joint of the human finger. The attachments to bone contain fibrocartilage, derived from the cartilage of the embryonic bone rudiment and rich in type II collagen and glycosaminoglycans. The attachment changes with age, when type II collagen spreads into the capsular ligament or tendon, or pathology--type II collagen is lost from PIP capsular attachments in rheumatoid arthritis. Parts of the capsule that are compressed during movement adapt by becoming fibrocartilaginous. Such regions accumulate cartilage-like glycosaminoglycans and may contain type II collagen, especially in aged material.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7928639

Ralphs, J R; Benjamin, M

1994-06-01

189

Co-ordinated research project on application of nuclear techniques in the prevention of degenerative diseases (obesity and non-insulin dependent diabetes) in ageing  

International Nuclear Information System (INIS)

In the developed countries, research using nuclear methods has been substantially used to examine the physiological and biochemical mechanisms involved in obesity-related diseases. This Co-ordinated Research Project (CRP) is intended to promote the use of these techniques in the developing world. The specific objectives of this CRP are: 1. To define the magnitude of the obesity/NIDDM problem in developing countries. 2. To identify vulnerable groups at high risk. 3. To describe the metabolic mechanisms involved. The purpose of this first Research Co-ordination Meeting (RCM) was thus to develop a worldwide collaboration in the use of nuclear and isotopic techniques to investigate the aetiology of degenerative diseases in ageing. All countries participating in this CRP are going through the epidemiological transition with changes in lifestyles to approach those seen in the developed nations. This first meeting was held in the Agency's headquarters in Vienna, with participation of contract and agreement holders, experts, observer, and in-house staff

1999-05-03

190

The diagnostic and prognostic significance of CT in neuro-degenerative, metabolic and leucodystrophic diseases in childhood  

International Nuclear Information System (INIS)

At the Hospital for Sick Children, Great Ormond Street, London, approximately 1% of the patients scanned with computed tomography (CT) are ultimately found to have neurological abnormalities due to a proven metabolic disease. To obtain all scanned cases of metabolic disease causing neurological abnormalities the clinical diagnosis at the time of referral for CT, the CT diagnosis and the records of the biochemical and neuropathological departments were reviewed. The material thus collected was then checked against the final diagnosis and only cases in which a precise diagnosis of a recognized metabolic disorder was established were included. The CT appearances are correlated with diagnosis, age at onset, duration and progress of the disease and prognosis. They show the various abnormalities diagnosed histologically or biochemically and may be helpful in the clinical context in suggesting the nature of the disease process. (Auth.)

1979-09-08

191

Combined scintigraphic and radiographic diagnosis of bone and joint diseases  

Energy Technology Data Exchange (ETDEWEB)

This book is intended to emphasize the tremendous value of pinhole scintigraphy in diagnosing nearly the whole spectrum of bone and joint diseases. Pinhole scintigraphy discloses anatomic and pathologic as well as chemical alterations in greater detail, permitting analytical interpretation and raising the sensitivity as well. Infections, nonspecific bone inflammation, rheumatic disorders, metabolic and endocrine bone diseases, trauma, and both primary tumors and metastasis can be effectively and specifically examined. By improving sensitivity, many false negative readings can be avoided in early bone metastasis, synovitis, enthesopathies, bone contusion, etc. (orig.)

Bahk, Yong Whee (Catholic Medical Coll., Seoul (Korea, Republic of). Dept. of Radiology and Nuclear Medicine)

1994-01-01

192

Degenerative diseases of the cervical spine: comparison of a multiecho data image combination sequence with a magnetisation transfer saturation pulse and cervical myelography and CT  

International Nuclear Information System (INIS)

Assessing degenerative disease in the cervical spine remains a challenge. There is much controversy about imaging the cervical spine using MRI. Our aim in this prospective study was to compare a T2*-weighted 2D spoiled gradient-echo multiecho sequence (MEDIC) with a magnetisation transfer saturation pulse with cervical myelography and postmyelographic CT. Using an assessment scale we looked at the vertebral bodies, intervertebral discs, neural foramina, anterior and posterior nerve roots, grey matter, ligamenta flava, oedema in the spinal cord and stenosis of the spinal canal. We also evaluated postmyelography CT and the MEDIC sequence for assessing narrowing of the neural foramina in a cadaver cervical spine. We examined 67 disc levels in 18 patients, showing 18 disc prolapses and 21 osteophytes narrowing the spinal canal or the neural foramina. All MRI studies showed these abnormalities findings equally well. Postmyelography CT was significantly better for showing the bony structures and the anterior and posterior nerve roots. The MEDIC sequence provided excellent demonstration of soft-tissue structures such as the intervertebral disc and ligamentum flavum. No statistical differences between the imaging modalities were found in the assessment of narrowing of the neural foramina or the extent of spinal stenosis. The cadaver measurements showed no overestimation of abnormalities using the MEDIC sequence. (orig.)

2004-04-01

193

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 14: Brace therapy as an adjunct to or substitute for lumbar fusion.  

Science.gov (United States)

The utilization of orthotic devices for lumbar degenerative disease has been justified from both a prognostic and therapeutic perspective. As a prognostic tool, bracing is applied prior to surgery to determine if immobilization of the spine leads to symptomatic relief and thus justify the performance of a fusion. Since bracing does not eliminate motion, the validity of this assumption is questionable. Only one low-level study has investigated the predictive value of bracing prior to surgery. No correlation between response to bracing and fusion outcome was observed; therefore a trial of preoperative bracing is not recommended. Based on low-level evidence, the use of bracing is not recommended for the prevention of low-back pain in a general working population, since the incidence of low-back pain and impact on productivity were not reduced. However, in laborers with a history of back pain, a positive impact on lost workdays was observed when bracing was applied. Bracing is recommended as an option for treatment of subacute low-back pain, as several higher-level studies have demonstrated an improvement in pain scores and function. The use of bracing following instrumented posterolateral fusion, however, is not recommended, since equivalent outcomes have been demonstrated with or without the application of a brace. PMID:24980591

Dailey, Andrew T; Ghogawala, Zoher; Choudhri, Tanvir F; Watters, William C; Resnick, Daniel K; Sharan, Alok; Eck, Jason C; Mummaneni, Praveen V; Wang, Jeffrey C; Groff, Michael W; Dhall, Sanjay S; Kaiser, Michael G

2014-07-01

194

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 6: Discography for patient selection.  

Science.gov (United States)

Identifying the etiology of pain for patients suffering from chronic low-back pain remains problematic. Noninvasive imaging modalities, used in isolation, have not consistently provided sufficient evidence to support performance of a lumbar fusion. Provocative testing has been used as an adjunct in this assessment, either alone or in combination with other modalities, to enhance the diagnostic capabilities when evaluating patients with low-back pain. There have been a limited number of studies investigating this topic since the publication of the original guidelines. Based primarily on retrospective studies, discography, as a stand-alone test, is not recommended to formulate treatment strategies for patients with low-back pain. A single randomized cohort study demonstrated an improved potential of discoblock over discography as a predictor of success following lumbar fusion. It is therefore recommended that discoblock be considered as a diagnostic option. There is a possibility, based on a matched cohort study, that an association exists between progression of degenerative disc disease and the performance of a provocative discogram. It is therefore recommended that patients be counseled regarding this potential development prior to undergoing discography. PMID:24980583

Eck, Jason C; Sharan, Alok; Resnick, Daniel K; Watters, William C; Ghogawala, Zoher; Dailey, Andrew T; Mummaneni, Praveen V; Groff, Michael W; Wang, Jeffrey C; Choudhri, Tanvir F; Dhall, Sanjay S; Kaiser, Michael G

2014-07-01

195

Artroplastia total cementada en enfermedad degenerativa de cadera: Su evaluación clínica / Arthroplastie totale cimentée dans la maladie dégénérative de hanche: Son évaluation clinique / Cemented total arthrosplasty in degenerative hip disease: Its clinical ev  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio descriptivo, transversal y prospectivo con el objetivo de evaluar la evolución clínica de 12 pacientes operados por enfermedad degenerativa articular a los que se les realizó sustitución protésica total cementada primaria de cadera, en el período comprendido entre enero de 2004 [...] a diciembre de 2006. Se incluyeron pacientes en edades de 50 años y más. Para su evaluación se utilizó la puntuación de la Clínica de los Hermanos Mayo, creada en 1985, la cual otorga un máximo de 80 puntos. Como resultado se obtuvo que 10 pacientes fueron evaluados entre excelente y bien, para un 83,3 %, y el promedio de la evaluación por dicha escala fue de 68,5 puntos, con 6 caderas por encima de esta cifra, lo que constituyó el 50% de la muestra. Se demostró el bienestar social que recibieron los pacientes sometidos a este proceder quirúrgico en nuestro centro hospitalario. Abstract in english A descriptive, cross-sectional and prospective study was conducted in order to evaluate the clinical evolution of 12 patients operated on due to degenerative joint disease that underwent cemented primary total prosthetic replacement of the hip from January 2004 to December 2006. Patients 50 and over [...] were included. For their evaluation it was used the scoring system of Mayo Clinic created in 1985, which gives a maximum of 80 points. As a result 10 patients were evaluated as good or excellent, accounting for 83.3 %. The average evaluation according to this scale was 68.5 points, with 6 hips over this figure, which represented 50 % of the sample. The social well-being received by the patients that underwent this surgical procedure was proved.

Orlando Manuel, Pérez Rivera; Lourdes E., Palanco Domínguez.

196

Lysis of major histocompatibility complex class I-bearing cells in Borna disease virus-induced degenerative encephalopathy.  

Science.gov (United States)

CD8+ as well as CD4+ T cells and macrophages are of crucial importance for the pathogenesis of Borna disease in rats. This virus-induced immunopathological disease of the brain is characterized by neurological symptoms in the acute phase and chronic debility associated with severe loss of brain tissue in the late stage. We demonstrate here the cytotoxic activity of T lymphocytes in the brain of intracerebrally infected rats. T cells isolated from the brain of infected rats lyse major histocompatibility complex (MHC) class I-bearing target cells in the absence of MHC class II. Borna disease virus (BDV)-infected syngeneic skin cells and astrocytes, the latter one of the relevant target cells in vivo, were significantly lysed whereas infected allogeneic target cells were not. Most relevant to the in vivo situation, primary brain cell cultures propagated from the hippocampus of BDV-infected rats containing considerable numbers of neurons were lysed in vitro. Blocking experiments using antibodies directed against MHC class I antigen provided further evidence for the presence and activity of classical cytotoxic T lymphocytes. Antibodies against MHC class II antigen did not influence lysis of skin target cells but had an effect on lysis of astrocytes at late time points. Lymphocytes isolated from spleen, peripheral blood, or lymph nodes did not show cytotoxic activity. These results verify, on the cellular level, earlier findings that strongly suggest the involvement of CD8+ T cells in brain cell lesions, resulting in brain atrophy long after infection of rats with BDV. This is further evidenced by the presence of CD8+ T cells in direct proximity to neuronal cell lesions. Interestingly, the cytolytic capacity, demonstrated in vitro and strongly correlated to organ destruction, does not result in elimination of the virus but the virus persists in the central nervous system. PMID:8315376

Planz, O; Bilzer, T; Sobbe, M; Stitz, L

1993-07-01

197

Proximal interphalangeal joint fracture dislocations.  

Science.gov (United States)

Proximal interphalangeal joint fracture dislocations are complex, potentially disabling injuries for any patient, especially the competitive athlete. Dorsal fracture dislocations are fairly common and volar fracture dislocations are rare. Stable injuries often heal with minimal functional deficit, whereas unstable injuries can result in limitation in range of motion, joint incongruity, and degenerative joint disease. A number of surgical procedures have been described to treat the unstable dorsal fracture dislocation, including ORIF, extension block pinning, external fixation, dynamic traction, and volar plate arthroplasty. Volar fracture dislocations are usually amenable to closed or open reduction and internal fixation. The results of treatment of both volar and dorsal fracture dislocations can be unpredictable. PMID:10955207

Glickel, S Z; Barron, O A

2000-08-01

198

Proteinograma do líquido cefalorraqueano em afecções degenerativas do sistema nervoso central / Protein pattern of the cerebrospinal fluid in degenerative diseases of the central nervous system  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Estudo baseado na análise dos dados referentes ao proteinograma do LCR de 28 pacientes com afecções degenerativas do SNC, de diversos tipos. A alteração principal encontrada foi o aumento do teor de -globulina, observado em 12 casos. O aumento dessa globulina ocorreu especialmente em casos com acome [...] -timento predominantemente encefálico (10 casos). Não foi observada relação entre o aumento de ?-globulina no LCR e os grupos etiopatogênicos a que pertenciam os casos estudados. O comprometimento metabólico da célula nervosa nas afecções degenerativas do SNC parece ser o principal responsável pelo aumento de ?-globulina no LCR. Aspectos evolutivos de casos apresentados permitem verificar a relação existente entre a severidade e a extensão do processo degenerativo e o aumento dessa fração protêica no LCR. Abstract in english The total protein content and the protein fractions (paper electrophoresis) were determined in the CSF of 28 patients with degenerative diseases of the CNS. The diagnosis and the results obtained are presented in table 1. An increase in the ?-globulin content of the CFS was the main change found. It [...] was observed in 12 cases. The observation confirms the findings of other authors. The data were discussed and it was shown that the severity of the changes in the metabolism of nerve cells and the extension of the process are more able to explain the increase in the ?-globulin content of the CSF. The occurrence of an increase in the ?-globulin content of the CSF was related to the localization and extension of the disease process within the CNS and not to the etiology. The distribution of the cases according to the possible site of the lesion in the CNS shows that the increase in the ?-globulin of the CSF was more frequent when signs of encephalic involvement were patent (table 2).

A., Spina-França.

199

Jacob's disease associated with temporomandibular joint dysfunction: a case report.  

Science.gov (United States)

Jacob's disease is regarded a rare condition in which a joint formation is established between an enlarged mandibular coronoid process and the inner aspect of the zygomatic body. Chronic temporomandibular joint (TMJ) disk displacement has been proposed as etiological factor of coronoid process enlargement. We present a 23-year-old woman with long-standing TMJ dysfunction and restricted interincisal opening, who developed a progressive zygomatic asymmetry. The patient underwent treatment by intraoral coronoidectomy and homolateral TMJ arthroscopy in the same surgery. The histopathological diagnosis of the coronoid sample was cartilage-capped exostoses with presence of articular fibrous cartilage. Although the low prevalence of this entity, it should be considered as a possible diagnosis in patients with progressive limitation of mouth opening, although a TMJ syndrome may be present as a cause of this entity. PMID:15876963

Capote, Ana; Rodríguez, Francisco J; Blasco, Ana; Muñoz, Mario F

2005-01-01

200

Symptomatic sacroiliac joint disease and radiographic evidence of femoroacetabular impingement.  

Science.gov (United States)

Symptomatic sacroiliac (SI) joint disease is poorly understood. The literature provides no clear aetiology for SI joint pathology, making evaluation and diagnosis challenging. We hypothesised that patients with documented sacroiliac pain might provide insight into the aetiology of these symptoms. Specifically, we questioned whether SI joint symptoms might be associated with abnormal hip radiographs. We reviewed the pelvic and hip radiographs of a prospectively collected cohort of 30 consecutive patients with SI joint pathology. This database included 33 hips from 30 patients. Radiographic analysis included measurements of the lateral centre edge angle, Tönnis angle, and the triangular index, of the ipsilateral hip. Evidence for retrotorsion of the hemipelvis was recorded. Hips were graded on the Tönnis grading system for hip arthrosis. In this cohort 14/33 (42%) of hips had evidence of significant osteoarthrosis indicated by Tönnis grade 2 or greater and 15/33 (45%) displayed subchondral cyst formation around the hip or head neck junction. In assessing acetabular anatomy, 21% (7/33) had retroversion, 12% (4/33) had a lateral centre edge angle >40° with 3% (1/33) >45°. Tönnis angle was <0° in 27% (9/33). Coxa profunda and acetabuli protrusio were present in 47% (17/33) and 3% (1/33), respectively. When femoral head morphology was assessed, 33% (11/33) showed evidence of cam impingement. Overall, 76% (25/33) had at least one abnormality on their hip radiograph. A significant number of patients meeting strict diagnostic criteria for SI joint pain had radiographic evidence of femoroacetabular impingement (FAI) and hip arthrosis. The clinician should maintain FAI in the differential diagnosis when investigating patients with buttock pain. PMID:23417531

Morgan, Patrick M; Anderson, Anthony W; Swiontkowski, Marc F

2013-01-01

 
 
 
 
201

Degenerative cartilage lesions of the hip--magnetic resonance evaluation.  

Science.gov (United States)

The capability of magnetic resonance imaging (MRI) to visualize early degenerative arthritis of the hip was investigated. The study was performed on 8 healthy students and 45 elderly volunteers. Images were obtained by using an electronically variable Helmholtz coil (switched-array coil, SAC). In order to diagnose degenerative lesions of the joint cartilage, FISP sequences with a flip angle of 70 degrees were found preferable to compared sequences. MRI-detectable signs of degenerative arthritis of the hip were narrowed joint space due to partially thinned cartilage layers, focal areas of either increased or decreased signal intensity in the hyaline cartilage, complete loss of cartilage, and signal variation in the bone marrow. MRI of the hip may be appropriate to detect early degenerative changes in the hips of young high-risk patients to facilitate therapy planning. PMID:2716485

Bongartz, G; Bock, E; Horbach, T; Requardt, H

1989-01-01

202

Molecular size distribution of somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with degenerative brain disease.  

Science.gov (United States)

The molecular size distribution of somatostatin-like immunoreactivity (SLI) in the cerebrospinal fluid (CSF) of patients with brain disease was investigated by separation with a Sephadex G-25 superfine column and subsequent radioimmunoassay of the eluate. Marked heterogeneity of SLI in the CSF of control subjects as well as in demented patients, was observed. Controls and schizophrenics exhibited an SLI distribution pattern consisting mainly of two pronounced peaks: the first eluting with the void volume of the column; the second being compatible with a peptide of N-terminally extended somatostatin-14. SLI from the CSF of patients with senile dementia of the Alzheimer type (SDAT), multi-infarct dementia (MID) and normal pressure hydrocephalus (NPH) showed the same two peaks found in controls and schizophrenics; and in addition, a third peak co-eluting with somatostatin-14. However, this peak was more pronounced in patients with SDAT and MID than in patients with NPH. Re-chromatography of G-25 sf void volume immunoreactivity afforded two fractions of an apparent molecular weight of about 10,000 daltons and 15,500 daltons, respectively. PMID:2871533

Rissler, K; Cramer, H; Schaudt, D; Strubel, D; Gattaz, W F

1986-02-01

203

No difference in clinical outcome after posterolateral lumbar fusion between patients with isthmic spondylolisthesis and those with degenerative disc disease using pedicle screw instrumentation: a comparative study of 112 patients with 4 years of follow-up  

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We compared the clinical outcome after spinal fusion between patients with isthmic spondylolisthesis and those with degenerative disc disease of the lumbar spine, using multiple logistic regression analysis. A questionnaire describing medication, pain, vocational status and patient satisfaction was mailed to all the patients at a median interval of 4 years after their operation. Fusion was evaluated on plain radiographs at a minimum of 12 months after surgery, and patients were classified as ...

Gehrchen, Martin P.; Dahl, Benny; Katonis, Pavlos; Blyme, Peter; Tøndevold, Erik; Kiær, Thomas

2002-01-01

204

Stand-alone cage for posterior lumbar interbody fusion in the treatment of high-degree degenerative disc disease: design of a new device for an “old” technique. A prospective study on a series of 116 patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Chronic lumbar pain due to degenerative disc disease affects a large number of people, including those of fully active age. The usual self-repair system observed in nature is a spontaneous attempt at arthrodesis, which in most cases leads to pseudoarthrosis. In recent years, many possible surgical fusion techniques have been introduced; PLIF is one of these. Because of the growing interest in minimally invasive surgery and the unsatisfactory results reported in the literature (mainly due to t...

Costa, Francesco; Sassi, Marco; Ortolina, Alessandro; Cardia, Andrea; Assietti, Roberto; Zerbi, Alberto; Lorenzetti, Martin; Galbusera, Fabio; Fornari, Maurizio

2011-01-01

205

Radiotherapy of benign diseases  

Energy Technology Data Exchange (ETDEWEB)

Still today radiotherapy is of decisive relevance for several benign diseases. The following ones are briefly described in this introductory article: 1. Certain inflammatory and degenerative diseases as furuncles in the face, acute thrombophlebitis, recurrent pseudoriparous abscesses, degenerative skeletal diseases, cervical syndrome and others; 2. rheumatic joint diseases; 3. Bechterew's disease; 4. primary presenile osteoporosis; 5. syringomyelia; 6. endocrine ophthalmopathy; 7. hypertrophic processes of the connective tissue; 8. hemangiomas. A detailed discussion and a profit-risk analysis is provided in the individual chapters of the magazine.

Haase, W.

1982-10-11

206

Radiotherapy of benign diseases  

International Nuclear Information System (INIS)

Still today radiotherapy is of decisive relevance for several benign diseases. The following ones are briefly described in this introductory article: 1. Certain inflammatory and degenerative diseases as furuncles in the face, acute thrombophlebitis, recurrent sudoriparous abscesses, degenerative skeletal diseases, cervical syndrome and others; 2. rheumatic joint diseases; 3. Bechterew's disease; 4. primary presenile osteoporosis; 5. synringomyelia; 6. endocrine ophthalmopathy; 7. hypertrophic processes of the connective tissue; 8. hemangiomas. A detailed discussion and a profit-risk analysis is provided in the individual chapters of the magazine. (MG)

1982-10-11

207

Co-ordinated research project on application of nuclear techniques in the prevention of degenerative diseases (obesity and non-Insulin dependent diseases) in ageing. Report on the second research co-ordination meeting  

International Nuclear Information System (INIS)

In the developed countries, research using nuclear methods has been substantially used to examine the physiological and biochemical mechanisms involved in obesity-related diseases. This Co-ordinated Research Project (CRP) is intended to promote the use of these techniques in the developing world. The specific objectives of this CRP are: 1. To define the magnitude of the obesity/NIDDM problem in developing countries. 2. To identify vulnerable groups at high risk. 3. To describe the metabolic mechanisms involved. The purpose of this first Research Co-ordination Meeting (RCM) was thus to develop a worldwide collaboration in the use of nuclear and isotopic techniques to investigate the aetiology of degenerative diseases in ageing. All countries participating in this CRP are going through the epidemiological transition with changes in lifestyles to approach those seen in the developed nations

2001-06-25

208

Second research co-ordination meeting for the coordinated research project on 'Application of nuclear techniques in the prevention of degenerative diseases (obesity and non-insulin dependent diseases) in ageing'. Summary report  

International Nuclear Information System (INIS)

In the developed countries, research using nuclear methods has been substantially used to examine the physiological and biochemical mechanisms involved in obesity-related diseases. This Co-ordinated Research Project (CRP) is intended to promote the use of these techniques in the developing world. The specific objectives of this CRP are: 1. To define the magnitude of the obesity/NIDDM problem in developing countries. 2. To identify vulnerable groups at high risk. 3. To describe the metabolic mechanisms involved. The purpose of this first Research Co-ordination Meeting (RCM) was thus to develop a worldwide collaboration in the use of nuclear and isotopic techniques to investigate the aetiology of degenerative diseases in ageing. All countries participating in this CRP are going through the epidemiological transition with changes in lifestyles to approach those seen in the developed nations

2001-06-25

209

Cervical spine: degenerative conditions  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Degenerative cervical spine disorders will affect up to two-thirds of the population in their lifetime. While often benign and episodic in nature, cervical disorders may become debilitating resulting in severe pain and possibly neurologic sequelae. Non-operative treatment continues to play an important role in treating these patients, with medications, therapy and interventional pain injections playing increasing roles in treatment. Surgical treatment including anterior and posterior decompre...

Todd, Andrew G.

2011-01-01

210

Degenerative disc disease as a cause of back pain in the thalassaemic population: a case-control study using MRI and plain radiographs  

International Nuclear Information System (INIS)

The aim of this study was to test our observation that back pain in thalassemic patients could be caused by premature and extensive lumbar degenerative disc disease, when compared to non-thalassemic patients with back pain. Sixteen thalassemic patients with their sex- and age-matched controls were recruited into the study, 12 with thalassemia major, and 4 with thalassemia intermedia. Both the thalassemia patients and control subjects suffered from back pain, which was subjective rather than measured/pain scored. All subjects underwent magnetic resonance (MR) imaging of the lumbar spine, and 11 of the cases and 8 controls had lumbar spine radiographs. Each lumbar disc was scored for radiographic appearances and MR features of disc degeneration and disc protrusion. Proportion values for these parameters and median scores were derived at each disc level, and were analyzed and compared. There was a statistically-significant difference between proportion values of cases and controls for the MR features (P value=0.01, n=16) and the radiographic features (P value=0.01, n=11 cases, n=8 controls) of disc degeneration. The median disc level scores for the thalassemic group were uniformly high across all lumbar discs, and at all levels except at L 4/5. The control group conversely demonstrated a predilection for disc degeneration at L4/5 level. The distribution of lumbar disc degeneration in thalassemic patients with back pain is more extensive, severe and multi-level in nature compared to matched controls, and disc degeneration should be considered as a significant cause of back pain in this population group. (orig.)

2006-02-01

211

Anterior Cervical Discectomy and Fusion Using a Double Cylindrical Cage versus an Anterior Cervical Plating System with Iliac Crest Autografts for the Treatment of Cervical Degenerative Disc Disease  

Science.gov (United States)

Objective Anterior cervical discectomy and fusion (ACDF) is often complicated by subsidence, pseudoarthrosis, kyphosis, and graft donor site morbidities. To decrease the occurrence of these complications, various types of cages have been developed. We designed this retrospective study to analyze and compare the efficacy and outcomes of ACDF using double cylindrical cages (DCC) (BK Medical, Seoul, Korea) versus an anterior cervical plating system with autogenous iliac crest grafts. Methods Forty-eight patients were treated with autograft and plating (plate group), and 48 with DCC group from October 2007 to October 2011. We analyzed construct length, cervical lordotic curvarture, the thickness of the prevertebral soft tissue, segmental instability, and clinical outcomes. Results There were no significant differences between the two groups with regard to the decrease in construct length or cervical lodortic curvature at the 3-, 6-, and 12-month follow-ups. The prevertebral soft tissue was thinner in the DCC group than the plate group immediately after surgery and at the 3-, 6-, and 12-month follow-ups. The difference in interspinous distance on flexion-extension was shorter in the plate group than the DCC group at the 3- and 6-month follow-ups. However, there was no significant difference in this distance between the two groups at the 12-month follow-up. Conclusion A double cylindrical cage is a good alternative for fusion in patients with cervical degenerative diseases; the surgical method is relatively simple, allows good synostosis, has less associated prevertebral soft tissue swelling, and complications associated with autografting can be avoided.

Kim, Seong Joon

2014-01-01

212

Posterior Interspinous Fusion Device for One-Level Fusion in Degenerative Lumbar Spine Disease : Comparison with Pedicle Screw Fixation - Preliminary Report of at Least One Year Follow Up  

Science.gov (United States)

Objective Transpedicular screw fixation has some disadvantages such as postoperative back pain through wide muscle dissection, long operative time, and cephalad adjacent segmental degeneration (ASD). The purposes of this study are investigation and comparison of radiological and clinical results between interspinous fusion device (IFD) and pedicle screw. Methods From Jan. 2008 to Aug. 2009, 40 patients underwent spinal fusion with IFD combined with posterior lumbar interbody fusion (PLIF). In same study period, 36 patients underwent spinal fusion with pedicle screw fixation as control group. Dynamic lateral radiographs, visual analogue scale (VAS), and Korean version of the Oswestry disability index (K-ODI) scores were evaluated in both groups. Results The lumbar spine diseases in the IFD group were as followings; spinal stenosis in 26, degenerative spondylolisthesis in 12, and intervertebral disc herniation in 2. The mean follow up period was 14.24 months (range; 12 to 22 months) in the IFD group and 18.3 months (range; 12 to 28 months) in pedicle screw group. The mean VAS scores was preoperatively 7.16±2.1 and 8.03±2.3 in the IFD and pedicle screw groups, respectively, and improved postoperatively to 1.3±2.9 and 1.2±3.2 in 1-year follow ups (p<0.05). The K-ODI was decreased significantly in an equal amount in both groups one year postoperatively (p<0.05). The statistics revealed a higher incidence of ASD in pedicle screw group than the IFD group (p=0.029). Conclusion Posterior IFD has several advantages over the pedicle screw fixation in terms of skin incision, muscle dissection and short operative time and less intraoperative estimated blood loss. The IFD with PLIF may be a favorable technique to replace the pedicle screw fixation in selective case.

Kim, Ho Jung; Chun, Hyoung Joon; Oh, Suck Jun; Kang, Tae Hoon; Yang, Moon Sool

2012-01-01

213

Geographic variation in the surgical treatment of degenerative cervical disc disease: American Board of Orthopedic Surgery Quality Improvement Initiative; part II candidates.  

LENUS (Irish Health Repository)

STUDY DESIGN: Retrospective case series. OBJECTIVE: To examine and document the change in rates and the geographic variation in procedure type and utilization of plating by orthopedic surgeons for anterior cervical discectomy-fusion. SUMMARY OF BACKGROUND: Age- and sex-adjusted rates of cervical spine surgery have not increased, but the rate of cervical spinal fusion has, accounting for 41% of all fusion procedures in 2004. METHODS: Records were selected from the American Board of Orthopedic Surgeons part II examination from 1999 to 2008. Current Procedural Terminology (CPT) and International Classification of Diseases, 9th Revision, Clinical Modification (ICDM-9-CM) codes were used to determine utilization of structural allograft, autograft\\/interbody devices, and anterior cervical plating over time and within geographic region. Main outcome measures were physician workforce, and rates and variation of procedure types. RESULTS: From 1999 to 2008, the number of self-declared orthopedic spine surgeon candidates increased 24%. Over this period, the annual number of discectomies with fusions for degenerative cervical disc disease increased by 67%, whereas the number of such operations per surgeon operating on at least 1 such case increased 48% (P = 0.018). Interbody device (0%-31%; P < 0.0001), anterior cervical plating (39%-79%; P < 0.0001), and allograft (14%-59%; P < 0.0001) use increased, whereas autograft use decreased (86%-10%; P < 0.0001). The Southwest and Southeast were more likely than the Midwest to use interbody devices (OR: 2.42 and 1.66, respectively). The Southwest and Northeast were more likely than the Midwest to use autograft (OR: 1.55 and 1.49). The Southwest, Northeast, and Southeast were less likely to use allograft than the Midwest (OR: 0.408, 0.742, and 0.770). The Northeast was less likely and the Southeast more likely than the Midwest to utilize anterior cervical plating (OR: 0.67 and 1.33). Surgical complications were more often associated with autograft compared with allograft (OR: 1.61). CONCLUSION: From 1999 to 2008, the number of orthopedic surgeon candidates performing spine surgery has increased. These surgeons are performing more fusions and utilizing more structural allografts, interbody devices, and\\/or anterior cervical plates. Regional variations also remain in the types of constructs utilized.

McGuire, Kevin J

2012-02-01

214

Dementia neuro degenerative diseases and bio markers: a new strategy for an early diagnosis; Affections neurodegeneratives dementielles et biomarqueurs: une nouvelle strategie pour un diagnostic precoce  

Energy Technology Data Exchange (ETDEWEB)

the neuro degenerative dementia (particularly focal beginning forms) can be diagnosed earlier by analyzing the combination of the rate of phosphorylated tau protein, IITE score and perfusion in right anterior cingulate gyrus, the Broca area, and left angular gyrus. A prospective study is underway to validate this model. (N.C.)

Mahieu, F.; Du Boisgueheneuc, F.; Andrieux, A.; Neau, J.P.; Gil, R.; Houeto, J.L. [CHU de Poitiers, Service de neurologie, 86 (France); Salmon, F. [CHU de Poitiers, Service de neurologie, 86 (France); Paccalin, M. [CHU de Poitiers, Service de medecine nucleaire, 86 (France); Lecron, J.C. [universite de Poitiers, EA 4331, laboratoire inflammation, tissus epitheliaux et cytokines, pole biologie sante, 86 (France); Ingrand, P. [CHU de Poitiers, unite de methodologie de la recherche clinique, centre d' investigation clinique P 802, 86 (France)

2010-07-01

215

Degenerative lumbar spinal stenosis: evaluation and management.  

Science.gov (United States)

Degenerative lumbar spinal stenosis is caused by mechanical factors and/or biochemical alterations within the intervertebral disk that lead to disk space collapse, facet joint hypertrophy, soft-tissue infolding, and osteophyte formation, which narrows the space available for the thecal sac and exiting nerve roots. The clinical consequence of this compression is neurogenic claudication and varying degrees of leg and back pain. Degenerative lumbar spinal stenosis is a major cause of pain and impaired quality of life in the elderly. The natural history of this condition varies; however, it has not been shown to worsen progressively. Nonsurgical management consists of nonsteroidal anti-inflammatory drugs, physical therapy, and epidural steroid injections. If nonsurgical management is unsuccessful and neurologic decline persists or progresses, surgical treatment, most commonly laminectomy, is indicated. Recent prospective randomized studies have demonstrated that surgery is superior to nonsurgical management in terms of controlling pain and improving function in patients with lumbar spinal stenosis. PMID:22855855

Issack, Paul S; Cunningham, Matthew E; Pumberger, Matthias; Hughes, Alexander P; Cammisa, Frank P

2012-08-01

216

The joint capsule: structure, composition, ageing and disease.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The joint capsule is vital to the function of synovial joints. It seals the joint space, provides passive stability by limiting movements, provides active stability via its proprioceptive nerve endings and may form articular surfaces for the joint. It is a dense fibrous connective tissue that is attached to the bones via specialised attachment zones and forms a sleeve around the joint. It varies in thickness according to the stresses to which it is subject, is locally thickened to form capsul...

Ralphs, J. R.; Benjamin, M.

1994-01-01

217

Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint*  

Science.gov (United States)

Calcium pyrophosphate dihydrate deposition disease (CPDD, tophaceous pseudogout) is a rare crystal arthropathy characterized by calcium pyrophosphate crystal deposition in joint spaces, episodes of synovitis, and radiological features of chondrocalcinosis. We present a case of 61-year-old woman who presented with left temporomandibular joint (TMJ) pain, difficulty chewing, left facial numbness, left-sided hearing loss, and left TMJ swelling. Imaging of the temporal fossa revealed a large mass emanating from the temporal bone at the TMJ, extending into the greater wing of the sphenoid and involving the mastoid bone and air cells posteriorly. Fine needle aspiration demonstrated polarizable crystals with giant cells. Intraoperatively, the TMJ was completely eroded by the mass. Final pathology was consistent with tophaceous pseudogout. CPDD has rarely been reported involving the skull base. None of the cases originally described by McCarty had TMJ pseudogout. Symptoms are generally pain, swelling, and hearing loss. Management is nearly always surgical with many patients achieving symptomatic relief with resection. CPDD is associated with many medical problems (including renal failure, gout, and hyperparathyroidism), but our patient had none of these risk factors. This case demonstrates that CPDD can involve the skull base and is best treated with skull base surgical techniques.

Srinivasan, Vasisht; Wensel, Andrew; Dutcher, Paul; Newlands, Shawn; Johnson, Mahlon; Vates, George Edward

2012-01-01

218

Calcium pyrophosphate deposition disease of the temporomandibular joint.  

Science.gov (United States)

Calcium pyrophosphate dihydrate deposition disease (CPDD, tophaceous pseudogout) is a rare crystal arthropathy characterized by calcium pyrophosphate crystal deposition in joint spaces, episodes of synovitis, and radiological features of chondrocalcinosis. We present a case of 61-year-old woman who presented with left temporomandibular joint (TMJ) pain, difficulty chewing, left facial numbness, left-sided hearing loss, and left TMJ swelling. Imaging of the temporal fossa revealed a large mass emanating from the temporal bone at the TMJ, extending into the greater wing of the sphenoid and involving the mastoid bone and air cells posteriorly. Fine needle aspiration demonstrated polarizable crystals with giant cells. Intraoperatively, the TMJ was completely eroded by the mass. Final pathology was consistent with tophaceous pseudogout. CPDD has rarely been reported involving the skull base. None of the cases originally described by McCarty had TMJ pseudogout. Symptoms are generally pain, swelling, and hearing loss. Management is nearly always surgical with many patients achieving symptomatic relief with resection. CPDD is associated with many medical problems (including renal failure, gout, and hyperparathyroidism), but our patient had none of these risk factors. This case demonstrates that CPDD can involve the skull base and is best treated with skull base surgical techniques. PMID:23946918

Srinivasan, Vasisht; Wensel, Andrew; Dutcher, Paul; Newlands, Shawn; Johnson, Mahlon; Vates, George Edward

2012-10-01

219

The use of gadoteridol in MRI of rheumatic joint disease  

International Nuclear Information System (INIS)

Purpose: To investigate the diagnostic and clinical usefulness of a new non-ionic, hydrophilic gadolinium (III) chelate [Gd(HP-DO3A), gadoteridol, ProHance] and to compare it with Gd-DTPA (gadopentetate dimeglumine, Magnevist). Methods: In a Phase III clinical trial, 20 patients with rheumatic joint disease were examined before and after intravenous administration of gadoteridol in two different doses (0.1 and 0.3 mmol/kg body-weight). Magnetic resonance imaging (MRI) was performed at 1.5 T with T1-weighted FLASH and T2-weighted spin echo sequences. Fourteen patients were examined with gadopentetate dimeglumine for comparison. Dynamic changes of signal intensity in the joints and muscle tissue were determined quantitatively. Results: No significant changes in cardiovascular data and no adverse effects occurred after injection of gadoteridol. The 0.3 mmol/kg dose showed no advantage in diagnostic contrast over the 0.1 mmol/kg dose. No significant differences (p>0.01) were noted between gadoteridol and gadopentetate dimeglumine in patients with early rheumatoid arthritis. Conclusion: Gadoteridol proved useful in the detection of early rheumatoid arthritis. No significant differences were observed between the two gadoteridol doses. There were no diagnostically relevant differences between gadoteridol and gadopentetate dimeglumine. (orig.)

1996-02-01

220

Geographic Variation in the Surgical Treatment of Degenerative Cervical Disc Disease: American Board of Orthopedic Surgery (ABOS) Quality Improvement Initiative; Part II Candidates  

Science.gov (United States)

Study Design Retrospective case series Objective To examine and document the change in rates and the geographic variation in procedure type and utilization of plating by orthopaedic surgeons for anterior cervical discectomy--fusion (ACDF). Summary of Background Age- and gender-adjusted rates of cervical spine surgery have not increased but the rate of cervical spinal fusion has, accounting for 41% of all fusion procedures in 2004. Methods Records were selected from the American Board of Orthopaedic Surgeons Part II examination from 1999–2008. CPT and ICD-9-CM codes were used to determine utilization of structural allograft, autograft/interbody devices, and anterior cervical plating over time and within geographic region. Main outcome measures were physician workforce, and rates and variation of procedure types. Results From 1999 to 2008, the number of self-declared orthopaedic spine surgeon candidates increased 24%. Over this period, the annual number of discectomies with fusions for degenerative cervical disc disease increased by 67%, while the number of such operations per surgeon operating on at least one such case increased 48% (p=0.018). Interbody device (0% to 31%; p<0.0001), anterior cervical plating (39% to 79%; p<0.0001), and allograft (14% to 59%; p<0.0001) use increased, while autograft use decreased (86% to 10%; p<0.0001). The Southwest and Southeast were more likely than the Midwest to use interbody devices (OR 2.42 and 1.66 respectively). The Southwest and Northeast were more likely than the Midwest to use autograft (OR 1.55 and 1.49). The Southwest, Northeast, and Southeast were less likely to use allograft than the Midwest (OR 0.408, 0.742, and 0.770). The Northeast was less likely and the Southeast more likely than the Midwest to utilize anterior cervical plating (OR 0.67 and 1.33). Surgical complications were more often associated with autograft compared to allograft (OR 1.61). Conclusions From 1999–2008, the number of orthopaedic surgeon candidates performing spine surgery has increased. These surgeons are performing more fusions, and utilizing more structural allografts, interbody devices and/or anterior cervical plates. Regional variations also remain in the type of constructs utilized.

McGuire, Kevin J.; Harrast, John; Herkowitz, Harry; Weinstein, James N.

2012-01-01

 
 
 
 
221

Study of the Role of Nova Bone as a Filling Material in Cervical Cage in Anterior Fusion of Cervical Spine in Patients with Degenerative Cervical Disc Disease  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objectives: There are several reports about the therapeutic effects of cervical interbody cages for cervical
degenerative disorders. Few have addressed the role of the filling material in fusion and improving the clinical
symptoms. This study tries to study the effects of Novabone as a filling material in Solis cages in patients with
cervical disc protrusions. The results have been compared with the results from studies that used autografts to fill<...

2011-01-01

222

Correlative radiological, self-assessment and clinical analysis of evolution in instrumented dorsal and lateral fusion for degenerative lumbar spine disease. Autograft versus coralline hydroxyapatite  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This prospective longitudinal randomized clinical and radiological study compared the evolution of instrumented posterolateral lumbar and lumbosacral fusion using either coralline hydroxyapatite (CH), or iliac bone graft (IBG) or both in three comparable groups, A, B and C, which included 19, 18 and 20 patients, respectively, who suffered from symptomatic degenerative lumbar spinal stenosis and underwent decompression and fusion. The patients were divided randomly according to the graft used ...

Korovessis, Panagiotis; Koureas, Georgios; Zacharatos, Spyridon; Papazisis, Zisis; Lambiris, Elias

2005-01-01

223

Charcot-like joints in calcium pyrophosphate dihydrate deposition disease  

Energy Technology Data Exchange (ETDEWEB)

Two cases of Charcot-like joints in patients with pseudogout who were otherwise neurologically intact are presented. The arthropathy of pseudogout should include Charcot-like joints and it is emphasized that an apparent Charcot joint should raise the question of pseudogout.

Helms, C.A.; Chapman, G.S.; Wild, J.H.

1981-10-01

224

Charcot-like joints in calcium pyrophosphate dihydrate deposition disease  

International Nuclear Information System (INIS)

Two cases of Charcot-like joints in patients with pseudogout who were otherwise neurologically intact are presented. The arthropathy of pseudogout should include Charcot-like joints and it is emphasized that an apparent Charcot joint should raise the question of pseudogout. (orig.)

1981-01-01

225

Patellofemoral joint biomechanics and tissue engineering.  

Science.gov (United States)

Recent advances in the study of patellofemoral joint biomechanics have provided promising diagnosis and treatment modalities for patellofemoral joint disorders, such as quantitative assessment of cartilage lesions from noninvasive imaging, computer simulations of surgical procedures for optimizing surgical parameters and potentially predicting outcomes, and cartilage tissue engineering for the treatment of advanced degenerative joint disease. These technologies are still in development and their clinical potentials remain an ongoing topic of investigation. We review some of our progress in addressing these issues, and the important role of cartilage mechanics and lubrication in understanding the challenges regarding patellofemoral surgery and cartilage tissue engineering. PMID:15995425

Ateshian, Gerard A; Hung, Clark T

2005-07-01

226

Inflammatory joint disease: a comparison of liposome scanning, bone scanning, and radiography.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Patients with rheumatoid arthritis, psoriatic arthritis, and osteoarthritis were assessed by clinical evaluation, radiography, and joint scintigraphy using technetium labelled methylene diphosphonate (MDP) and technetium labelled liposomes. Although both scanning techniques were more sensitive than radiographs in detecting joint disease, the liposomes scans were positive only in clinically active inflammatory disease. In patients with rheumatoid arthritis liposome scintigraphy was also able t...

O Sullivan, M. M.; Powell, N.; French, A. P.; Williams, K. E.; Morgan, J. R.; Williams, B. D.

1988-01-01

227

Is tibiofemoral osteoarthritis in the knee joint a new disease?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVES--To compare the prevalence of osteoarthritis (OA) of the hip, tibiofemoral and patellofemoral joints in a skeletal population. METHODS--A total of 785 adult English skeletons (695 Saxon or Mediaeval origin) were examined for OA using established criteria. RESULTS--Twenty nine skeletons had hip OA, compared with 14 with patellofemoral joint OA, and only four tibiofemoral joint OA. CONCLUSION--Tibiofemoral OA was far less prevalent in ancient skeletons than hip or patellofemoral dise...

Rogers, J.; Dieppe, P.

1994-01-01

228

Anesthesia for joint replacement surgery: Issues with coexisting diseases  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The first joint replacement surgery was performed in 1919. Since then, joint replacement surgery has undergone tremendous development in terms of surgical technique and anesthetic management. In this era of nuclear family and independent survival, physical mobility is of paramount importance. In recent years, with an increase in life expectancy, advances in geriatric medicine and better insurance coverage, the scenario of joint replacement surgery has changed significantly. Increasing number ...

2011-01-01

229

The Influence of Magnetic Resonance Imaging Findings of Degenerative Disease on Dual-Energy X-ray Absorptiometry Measurements in Middle-Aged Men  

International Nuclear Information System (INIS)

Purpose: To examine degenerative features based on magnetic resonance imaging (MRI) measurements at the lumbar spine in relation to dual-energy X-ray absorptiometry (DXA), and to investigate whether bone mineral density (BMD) is reflected in the substitution of bone trabecular structure by fat at the vertebral body level indicated by MRI T1 relaxation time, endplate concavity, and hypertrophic (osteophytes and endplate sclerosis) MRI findings. Material and Methods: The sample for this cross-sectional study was composed of 102 subjects, 35-70 years old, from a population-based cohort. Data collection included DXA in the anterior-posterior projection at the L1-L4 vertebrae and right femoral neck, and MRI of the lumbar spine in the midsagittal plane. Results: Age, vertebral signal intensity, osteophytes, and endplate concavity collectively explained 20% of the variance in spine BMD. Conclusion: The study findings suggest that degenerative findings based on MRI measurements at the lumbar spine have an influence on bone assessment using DXA. Therefore, an overall bone assessment such as DXA might not offer an accurate measure of BMD

2007-02-01

230

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 8: Lumbar fusion for disc herniation and radiculopathy.  

Science.gov (United States)

Patients suffering from a lumbar herniated disc will typically present with signs and symptoms consistent with radiculopathy. They may also have low-back pain, however, and the source of this pain is less certain, as it may be from the degenerative process that led to the herniation. The surgical alternative of choice remains a lumbar discectomy, but fusions have been performed for both primary and recurrent disc herniations. In the original guidelines, the inclusion of a fusion for routine discectomies was not recommended. This recommendation continues to be supported by more recent evidence. Based on low-level evidence, the incorporation of a lumbar fusion may be considered an option when a herniation is associated with evidence of spinal instability, chronic low-back pain, and/or severe degenerative changes, or if the patient participates in heavy manual labor. For recurrent disc herniations, there is low-level evidence to support the inclusion of lumbar fusion for patients with evidence of instability or chronic low-back pain. PMID:24980585

Wang, Jeffrey C; Dailey, Andrew T; Mummaneni, Praveen V; Ghogawala, Zoher; Resnick, Daniel K; Watters, William C; Groff, Michael W; Choudhri, Tanvir F; Eck, Jason C; Sharan, Alok; Dhall, Sanjay S; Kaiser, Michael G

2014-07-01

231

Radiotherapy of rheumatic diseases of the bone joints  

Energy Technology Data Exchange (ETDEWEB)

Treatment of rheumatoid arthritis can be either systemic or local. 'Synoviorthesis', the intraarticular injection of radio-colloids, has shown to be very effective in withholding persistent synovitis, even compared with synovectomy. For large joints, e.g. knees, favourable results can be anticipated, with smaller joints results are poorer. Physical and biological data, indications and results are presented.

Makoski, H.B.; Stroetges, M.W.; Rau, R.; Schuette, H.

1982-10-11

232

Roentgenological semiotics of joint involvement in psoriasis  

International Nuclear Information System (INIS)

The paper is concerned with the results of an X-ray study of the osteoarticular system of 103 patients with arthropathic psoriasis. Four types of disease: psoriatic polyarthritis, psoriatic polyarthrosis, psoriatic arthropathy and a mixed or combined form (the combination of inflammatory and degenerative-dystrophic changes) - were defined on the basis of X-ray findings. Roentgenological semiotics of these forms of arthropathic psoriasis with the frequency of the involvement of some joints and elements of differential radiodiagnosis was proposed

1986-01-01

233

Synovial chondromatosis of the temporomandibular joint with calcium pyrophosphate dihydrate crystal deposition disease (pseudogout).  

Science.gov (United States)

This report describes a very rare case of synovial chondromatosis with deposition of calcium pyrophosphate dihydrate (CPPD) crystals (pseudogout) in the temporomandibular joint (TMJ) of a 46-year-old male patient. Synovial chondromatosis is a non-neoplastic disease characterized by metaplasia of the connective tissue leading to chondrogenesis in the synovial membrane. Pseudogout is an inflammatory disease of the joints caused by the deposition of CPPD, producing similar symptoms to those observed in gout but not hyperuricaemia. Both diseases commonly affect the knee, hip and elbow joints, but rarely affect the TMJ. PMID:23166363

Matsumura, Y; Nomura, J; Nakanishi, K; Yanase, S; Kato, H; Tagawa, T

2012-12-01

234

Development of PET tracers for neuro inflammation imaging in neuro degenerative diseases; Developpement de radiotraceurs de la neuroinflammation pour l'imagerie des pathologies neurodegeneratives  

Energy Technology Data Exchange (ETDEWEB)

Inflammatory processes such as micro-glial or endothelial activation are involved in many neuro-degenerative conditions. Neuro-inflammation imaging is considered an attractive tool for fundamental research, diagnosis and therapeutic evaluation in neuro-pathologies. First, an aptamer was selected against a recombinant fragment of the endothelial target VCAM-1, but proved unable to bind the target protein in native conformation, as expressed by a cell line. Second, five radioligands of the peripheral benzodiazepine receptor (PBR), a marker of micro-glial activation, were evaluated in vivo using PET (Positron Emission Tomography) imaging in a rat model of neuro-inflammation, and were compared to [11C]PK11195. Four radiotracers displayed a better contrast than [11C]PK11195. In a competitive field of research, this work demonstrates the efficiency of in vivo screening of radiotracers for fast selection of clinically relevant molecules. (author)

Chauveau, F

2007-10-15

235

A prospective morphological study of facet joint integrity following intervertebral disc replacement with the CHARITə Artificial Disc  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In degenerative disc disease (DDD), increased loading in the posterior column increases facet joint subchondral bone density and may lead to facet joint degeneration. While spinal fusion is commonly used to treat patients with symptomatic DDD, increased stress at the levels adjacent to fusion may accelerate facet joint and adjacent segment degeneration. Artificial disc replacements have been developed as an alternative to fusion. In this prospective study, the effects of disc replacement with...

Trouillier, Hans; Kern, P.; Refior, H. J.; Mu?ller-gerbl, M.

2006-01-01

236

Carpal instabilities and secondary degenerative changes due to lesions of the radiocarpal ligament complex  

International Nuclear Information System (INIS)

This paper reports on trauma, rheumatoid arthritis, calcium pyrophosphate dihydrate crystal deposition (CPDD), neurologic disease, and beta2-microglobulin-related amyloid deposits in patients undergoing chronic hemodialysis that can lead to distinct lesions of the radiocarpal ligament complex, causing rotational subluxation of the scaphoid and ulnar translocation of the carpus. The clinical and radiologic findings were analyzed in 35 patients, examined from 1985 to 1989. Degenerative changes in rotational subluxation of the scaphoid develop in three steps. First there is osteoarthritis at the styloid process, then the degeneration progresses into the central midcarpal joint, and finally it progresses to the ulnar midcarpal joint. Despite different etiologies of ligament failure, the radiologic features are very similar, because the mechanism of degeneration is identical in posttraumatic, inflammatory, neurogenic, CPDD, or beta2-microglobulin-related instability. However, there are some distinct radiologic differences in relation to the primary cause of the ligament defect

1990-11-25

237

Surgical treatment of adult degenerative scoliosis.  

Science.gov (United States)

The rapid increase of elderly population has resulted in increased prevalence of adult scoliosis. Adult scoliosis is divided into adult idiopathic scoliosis and adult degenerative scoliosis. These two types of scoliosis vary in patient age, curve pattern and clinical symptoms, which necessitate different surgical indications and options. Back pain and deformity are major indications for surgery in adult idiopathic scoliosis, whereas radiating pain to the legs due to foraminal stenosis is what often requires surgery in adult degenerative scoliosis. When selecting a surgical method, major symptoms and underlying medical diseases should be carefully evaluated, not only to relieve symptoms but also to minimize postoperative complications. Surgical options for adult degenerative scoliosis include: decompression alone; decompression and limited short fusion; and decompression coupled with long fusion and correction of deformity. Decompression and limited short fusion can be applied to patients with a small Cobb's angle and normal sagittal imbalance. For those with a large Cobb's angle and positive sagittal imbalance, long fusion with correction of deformity is required. When long fusion is applied, a careful decision regarding the extent of fusion level should be made when selecting L5 or S1 as the distal fusion level and T10 or the thoracolumbar junction as the proximal fusion level. For the fusion extending to the sacrum, restoration of sagittal balance and rigid fixation with additional iliac screws should be considered. Any surgical procedures for adult degenerative scoliosis are known to have relatively high occurrences of complications; therefore, risks and benefits should be meticulously considered before selecting a surgical procedure. PMID:24967054

Cho, Kyu-Jung; Kim, Young-Tae; Shin, Sang-Hyun; Suk, Se-Il

2014-06-01

238

Degenerative disc disease of the lumbar spine: a prospective comparison of fast T1-weighted fluid-attenuated inversion recovery and T1-weighted turbo spin echo MR imaging  

International Nuclear Information System (INIS)

Objective: To compare fast T1-weighted fluid-attenuated inversion recovery (FLAIR) and T1-weighted turbo spin-echo (TSE) imaging of the degenerative disc disease of the lumbar spine. Materials and methods: Thirty-five consecutive patients (19 females, 16 males; mean age 41 years, range 31-67 years) with suspected degenerative disc disease of the lumbar spine were prospectively evaluated. Sagittal images of the lumbar spine were obtained using T1-weighted TSE and fast T1-weighted FLAIR sequences. Two radiologists compared these sequences both qualitatively and quantitatively. Results: On qualitative evaluation, CSF nulling, contrast at the disc-CSF interface, the disc-spinal cord (cauda equina) interface, and the spinal cord (cauda equina)-CSF interface of fast T1-weighted FLAIR images were significantly higher than those for T1-weighted TSE images (P < 0.001). On quantitative evaluation of the first 15 patients, signal-to-noise ratios of cerebrospinal fluid of fast T1-weighted FLAIR imaging were significantly lower than those for T1-weighted TSE images (P < 0.05). Contrast-to-noise ratios of spinal cord/CSF and normal bone marrow/disc for fast T1-weighted FLAIR images were significantly higher than those for T1-weighted TSE images (P < 0.05). Conclusion: Results in our study have shown that fast T1-weighted FLAIR imaging may be a valuable imaging modality in the armamentarium of lumbar spinal T1-weighted MR imaging, because the former technique has definite superior advantages such as CSF nulling, conspicuousness of the normal anatomic structures and changes in the lumbar spinal discogenic disease and image contrast and also almost equally acquisition times

2005-08-01

239

Relationship between arthroscopic joint evaluation and the levels of Coll2-1, Coll2-1NO2, and myeloperoxidase in the blood and synovial fluid of horses affected with osteochondrosis of the tarsocrural joint  

DEFF Research Database (Denmark)

Objective: To evaluate the levels of plasmatic and synovial Coll2-1, Coll2-1NO and myeloperoxidase (MPO) in horses with osteochondral lesions of the tarsocrural joint and to investigate how these levels relate to arthroscopic findings of inflammation and degeneration. Materials and methods: Venous blood and synovial fluid samples were collected from 63 horses presented for arthroscopic removal of osteochondral fragments in the tarsocrural joint. Prior to removal of the osteochondral fragment, an exploration of the joint was performed and an inflammatory and degenerative score was determined. The blood and synovial levels of Coll2-1, Coll2-1NO and MPO were also measured. The effects of the arthroscopic evaluation (inflammatory and degenerative classes) on the blood and synovial markers were evaluated using a linear model (GLM procedure), and correlations between biochemical markers in the blood and synovial fluid and the arthroscopic evaluation (inflammatory and degenerative classes) were established (Pearson's correlations). Results: Significantly higher levels of Coll2-1 were detected in synovial fluid of higher degenerative classes. There was a significant correlation between the degenerative score and the synovial levels of Coll2-1 (r= 0.27). According to the logistic regression model, there was a significant effect of the degenerative class on synovial levels of Coll2-1. Conclusions: Coll2-1 correlates well with the degenerative state of tarsocrural joints as evaluated by arthroscopy. This marker can therefore be classified as a burden-of-disease marker in the assessment of joint disease in horses. © 2011 Osteoarthritis Research Society International.

Verwilghen, D.R.; Balligand, M.

2011-01-01

240

Arthroscopy in 19 children with Perthes' disease. Pathologic changes of the synovium and the joint surface.  

Science.gov (United States)

Arthroscopy of the hip joint was performed in 19 children with Legg-Calvé-Perthes' disease. Proliferation of the synovium was pronounced both in the acetabular fossa and over the inner wall of the capsule. Hypervascularity was seen on the acetabular labrum in every stage of the disease. Microscopically, hyperplasia of the synovial lining cells was observed, but inflammatory changes in the synovial tissue were inconspicuous in the early stage of the disease. Although hypertrophy of the endothelial cells of the vessels was seen in the late stage of the disease, it was not distinct in the initial or fragmentation stages. Joint pain improved after irrigation during arthroscopy. PMID:7839839

Suzuki, S; Kasahara, Y; Seto, Y; Futami, T; Furukawa, K; Nishino, Y

1994-12-01

 
 
 
 
241

Development of modulators against degenerative aging using radiation fusion technology  

International Nuclear Information System (INIS)

1. Objectives Establishment of modelling of degenerative aging using radiation technology Development of aging modulators using radiation degenerative aging model 2. Project results Establishment of the modeling of degenerative aging using radiation technology - The systematic study on the comparison of radiation-induced degeneration and natural aging process in animals and cells confirmed the biological similarity between these two degeneration models - The effective biomarkers were selected for the modelling of degenerative aging using radiation (10 biomarkers for immune/hematopoiesis, 1 for oxidative stress, 6 for molecular signaling, 3 for lipid metabolism) - The optimal irradiation condition was established for the modelling of degerative aging (total 5Gy with fractionation by over 10 times, lapse of over 4 months) - The molecular mechanisms of radiation-induced degeneration were studied including chronic inflammation (lung), inflammation-related lipid metabolism disturbance, mitochondria biogenesis and dynamics - The radiation degenerative model was evaluated with previously known natural substances (resveratrol, EGCG, etc) Development of aging modulators using radiation degenerative aging model - After the screening of about 800 natural herb extracts, 5 effective substances were selected for aging modulation. - 3 candidate compositions were selected from 20 compositions made from effective substances by in vitro evaluation (WAH2, WAH6, WAH7) - 1 composition (WAH6) was selected as the best aging modulator by in vivo evaluation in radiation-induced aging models and degenerative disease models. 3. Expected benefits and plan of application The modelling of degenerative aging using radiation can facilitate the aging research by providing the useful cell/animal models for aging research A large economic benefits are expected by the commercialization of developed aging modulators (over 10 billion KW in 2015

2012-01-01

242

Principales aspectos clínicos y endoscópicos de la enfermedad degenerativa de la rodilla / Main clinical and endoscopical aspects of the degenerative knee disease  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio descriptivo y transversal de 100 pacientes atendidos en el Servicio de Reumatología del Hospital Provincial Docente "Saturnino Lora" de Santiago de Cuba con el diagnóstico de artropatía degenerativa de la rodilla, durante el período 2003-2007, a fin de caracterizarles según los [...] principales aspectos clínicos y endoscópicos de esta afección. Entre los principales resultados sobresalieron: los pacientes con más de 60 años y el sexo femenino. La gonartrosis y la condromalacia constituyeron los hallazgos endoscópicos fundamentales y como opciones terapéuticas más empleadas, predominaron el legrado y el lavado articular. Abstract in english A descriptive and cross-sectional study with one-hundred patients having a diagnosis of degenerative knee arthropathy treated at the Rheumatology Service in ¨Saturnino Lora¨ University Hospital from Santiago de Cuba was carried out between 2003 and 2007 in order to characterize them according to the [...] main clinical and endoscopical aspects of this disorder. Among the most important results, 60-year-old and over patients and female gender were relevant. Gonarthrosis and condromalacy constituted the main endoscopical findings while curettage and articular wash-out, being the therapeutical alternatives most used, were predominant.

Morasén Cuevas, José Ricardo; Calisté Manzano, Osvaldo; Vergés Callard, Luis.

243

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 10: Lumbar fusion for stenosis without spondylolisthesis.  

Science.gov (United States)

Lumbar stenosis is one of the more common radiographic manifestations of the aging process, leading to narrowing of the spinal canal and foramen. When stenosis is clinically relevant, patients often describe activity-related low-back or lower-extremity pain, known as neurogenic claudication. For those patients who do not improve with conservative care, surgery is considered an appropriate treatment alternative. The primary objective of surgery is to reconstitute the spinal canal. The role of fusion, in the absence of a degenerative deformity, is uncertain. The previous guideline recommended against the inclusion of lumbar fusion in the absence of spinal instability or a likelihood of iatrogenic instability. Since the publication of the original guidelines, numerous studies have demonstrated the role of surgical decompression in this patient population; however, few have investigated the utility of fusion in patients without underlying instability. The majority of studies contain a heterogeneous cohort of subjects, often combining patients with and without spondylolisthesis who received various surgical interventions, limiting fusions to those patients with instability. It is difficult if not impossible, therefore, to formulate valid conclusions regarding the utility of fusion for patients with uncomplicated stenosis. Lower-level evidence exists, however, that does not demonstrate an added benefit of fusion for these patients; therefore, in the absence of deformity or instability, the inclusion of a fusion is not recommended. PMID:24980587

Resnick, Daniel K; Watters, William C; Mummaneni, Praveen V; Dailey, Andrew T; Choudhri, Tanvir F; Eck, Jason C; Sharan, Alok; Groff, Michael W; Wang, Jeffrey C; Ghogawala, Zoher; Dhall, Sanjay S; Kaiser, Michael G

2014-07-01

244

Joint pain  

Science.gov (United States)

... more joints. See also: Arthritis (inflammation of joints) Bursitis Muscle pain ... Autoimmune diseases such as rheumatoid arthritis and lupus Bursitis Chondromalacia patellae Gout (especially found in the big ...

245

Injuries of bones and bone joints in case of various infections, fungous and parasitogenic diseases  

International Nuclear Information System (INIS)

The radiologic method is shown to play an essential role in early diagnosis and particularly in determination of the rate of occurrence of bone and bone joint injuries in case of various injectons, fungous and parasitogenic diseases. Roentgenologic characteristics of different bone diseases are presented. A necessity of differential diagnosis, conducted on the basis of disease course, analysis, dinical manifestations of the main disease is underlined

1984-01-01

246

Inflammatory joint disease and human immunodeficiency virus infection  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Nine men positive for antibody to human immunodeficiency virus (HIV) who developed peripheral, non-erosive arthritis were followed up. The clinical features were compatible with reactive arthritis but were atypical in several respects: the joint symptoms were generally severe, persistent, and unresponsive to non-steroidal anti-inflammatory drugs. The onset of arthritis was associated with various infections, none of which are known to be associated with the development of reactive arthritis. ...

Forster, S. M.; Seifert, M. H.; Keat, A. C.; Rowe, I. F.; Thomas, B. J.; Taylor-robinson, D.; Pinching, A. J.; Harris, J. R. W.

1988-01-01

247

The degenerative and traumatized knee: Use of radioisotopes for diagnosis, evaluation and treatment  

International Nuclear Information System (INIS)

Full text: Bone SPECT is a highly valuable method of investigation for the assessment of the knee joint. Its speed and low cost probably make it a suitable screening procedure for most knee traumatic and degenerative diseases. Consequently, bone SPECT is inevitably seen as a competitive and complementary procedure to MRI. The technique of radiation synovectomy has been available for more than 40 years in the management of joint diseases. Recently, there has been renewed interest in radiation synovectomy, following the introduction of some new and efficient radiopharmaceuticals. We present here our experience with the diagnosis and treatment of the traumatized and degenerative knees in 358 patients, together with the review of the literature. A special emphasis will be placed on the following topics: 1. Correlative imaging of planar and SPECT scintigraphy with correlation to MRI. 2. Quantitative and prognostic parameters. 3. The value of the method in sports and military medicine. 4. The value of bone scintigraphy in choosing candidates and planning arthroscopic and radiation synovectomy. 5. The clinical efficacy of particulate versus colloid radiopharmaceutical for radiation synovectomy. 6. The response rate to a single injection versus routine repeated injections of the radiopharmaceutical. 7. The clinical importance of some different techniques of treatment in different clinics, including injected dose, injection procedure, safety precautions, etc. 8. Comparison of the efficacy of radiation synovectomy to intra-articular corticosteroid injection. 9. The use of different 90Y colloids (resin, citrate, cilicate and ferric hydroxide), comparing especially the extent of regional lymph node irritation as a result of joint leakage. 10. The clinical importance of co-injection of corticosteroids with the radiopharmaceutical, in either colloidal or particular radiopharmaceuticals. 11. The importance of combined procedures of saline irrigation with radiopharmaceutical and/or possible corticosteroid injection, for improving patients' outcome. 12. The value of post treatment full rest (hospitalization?) to prevent extra- articular leakage and optimal response. 13. Some financial and cost-effective considerations. (author)

2007-07-01

248

Predisposing factors in degenerative spondylolisthesis : A radiographic and CT study  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We report a prospective study analysing whether possible factors predisposing to degenerative spondylolisthesis (DS) must be present concomitantly in order to cause vertebral slipping. Standard and flexion-extension radiographs were obtained from 27 patients with DS and 27 without spondylolisthesis. The level of the intercrestal line, the lumbosacral angle, the presence of sacralization of L5 and vertebral motion at the L4?–?L5 level were assessed. Facet joint or...

Cinotti, G.; Postacchini, F.; Fassari, F.; Urso, S.

1997-01-01

249

Radiology of the hand bones. Pt. 1. Inflammative diseases of the joints and rheumatology  

International Nuclear Information System (INIS)

The contributions in the section on ''advanced training'' reflect the knowledge required of doctors specializing in diagnostic radiology and may also serve as a revision course for medical practicioners. It presents clinically validated information on the following subjects: Rheumatoid arthritis (radiological model) - four classes of radiological signs of arthritis - hydrarthrosis, haemarthrosis and serosynovitis - osteopenia near the joints (where direct signs may not be available until several months or years after the onset of the disease) - 'signal cysts' - changes in the limiting lamina (which require careful observation under a magnifying glass) - pannus (an indication of arthritis of the joints) - mutilation - false positions of the joints

1999-05-01

250

Investigation of the spine by single photon emission computed tomography (SPECT) in rheumatoid spondylitis, in degenerative, traumatic and malignant diseases of the spine and in osteoid-osteoma  

International Nuclear Information System (INIS)

SPECT has been used in a comparative study with planar bone scintigraphy in 54 patients. Spatial resolution of the method is sufficient to localise the vertebral bodies, the spinous processes, the intervertebral, costotransverse and costovertebral joints. In all patients it was possible to relate the areas of increased uptake to specific anatomical sites of the spine known to be affected in the different conditions. A detailed localisation is rarely possible using planar scintigraphy alone, due to the complex osseous anatomy of the spine. In some patients lesions could be seen only with SPECT. SPECT is an invaluable supplement to planar scintigraphy of the spine. (orig)

1986-01-01

251

Comparison of the costs of nonoperative care to minimally invasive surgery for sacroiliac joint disruption and degenerative sacroiliitis in a United States commercial payer population: potential economic implications of a new minimally invasive technology  

Science.gov (United States)

Introduction Low back pain is common and treatment costly with substantial lost productivity and lost wages in the working-age population. Chronic low back pain originating in the sacroiliac (SI) joint (15%–30% of cases) is commonly treated with nonoperative care, but new minimally invasive surgery (MIS) options are also effective in treating SI joint disruption. We assessed whether the higher initial MIS SI joint fusion procedure costs were offset by decreased nonoperative care costs from a US commercial payer perspective. Methods An economic model compared the costs of treating SI joint disruption with either MIS SI joint fusion or continued nonoperative care. Nonoperative care costs (diagnostic testing, treatment, follow-up, and retail pharmacy pain medication) were from a retrospective study of Truven Health MarketScan® data. MIS fusion costs were based on the Premier’s Perspective™ Comparative Database and professional fees on 2012 Medicare payment for Current Procedural Terminology code 27280. Results The cumulative 3-year (base-case analysis) and 5-year (sensitivity analysis) differentials in commercial insurance payments (cost of nonoperative care minus cost of MIS) were $14,545 and $6,137 per patient, respectively (2012 US dollars). Cost neutrality was achieved at 6 years; MIS costs accrued largely in year 1 whereas nonoperative care costs accrued over time with 92% of up front MIS procedure costs offset by year 5. For patients with lumbar spinal fusion, cost neutrality was achieved in year 1. Conclusion Cost offsets from new interventions for chronic conditions such as MIS SI joint fusion accrue over time. Higher initial procedure costs for MIS were largely offset by decreased nonoperative care costs over a 5-year time horizon. Optimizing effective resource use in both nonoperative and operative patients will facilitate cost-effective health care delivery. The impact of SI joint disruption on direct and indirect costs to commercial insurers, health plan beneficiaries, and employers warrants further consideration.

Ackerman, Stacey J; Polly, David W; Knight, Tyler; Schneider, Karen; Holt, Tim; Cummings, John

2014-01-01

252

Comparison of the costs of nonoperative care to minimally invasive surgery for sacroiliac joint disruption and degenerative sacroiliitis in a United States commercial payer population: potential economic implications of a new minimally invasive technology  

Directory of Open Access Journals (Sweden)

Full Text Available Stacey J Ackerman,1 David W Polly Jr,2 Tyler Knight,3 Karen Schneider,4 Tim Holt,5 John Cummings Jr6 1Covance Market Access Services Inc., San Diego, CA, USA; 2University of Minnesota, Orthopaedic Surgery, Minneapolis, MN, USA; 3Covance Market Access Services Inc., Gaithersburg, MD, USA; 4Covance Market Access Services Inc., Sydney, Australia; 5Montgomery Spine Center, Orthopedic Surgery, Montgomery, AL, USA; 6Community Health Network, Neurosurgery, Indianapolis, IN, USA Introduction: Low back pain is common and treatment costly with substantial lost productivity and lost wages in the working-age population. Chronic low back pain originating in the sacroiliac (SI joint (15%–30% of cases is commonly treated with nonoperative care, but new minimally invasive surgery (MIS options are also effective in treating SI joint disruption. We assessed whether the higher initial MIS SI joint fusion procedure costs were offset by decreased nonoperative care costs from a US commercial payer perspective. Methods: An economic model compared the costs of treating SI joint disruption with either MIS SI joint fusion or continued nonoperative care. Nonoperative care costs (diagnostic testing, treatment, follow-up, and retail pharmacy pain medication were from a retrospective study of Truven Health MarketScan® data. MIS fusion costs were based on the Premier's Perspective™ Comparative Database and professional fees on 2012 Medicare payment for Current Procedural Terminology code 27280. Results: The cumulative 3-year (base-case analysis and 5-year (sensitivity analysis differentials in commercial insurance payments (cost of nonoperative care minus cost of MIS were $14,545 and $6,137 per patient, respectively (2012 US dollars. Cost neutrality was achieved at 6 years; MIS costs accrued largely in year 1 whereas nonoperative care costs accrued over time with 92% of up front MIS procedure costs offset by year 5. For patients with lumbar spinal fusion, cost neutrality was achieved in year 1. Conclusion: Cost offsets from new interventions for chronic conditions such as MIS SI joint fusion accrue over time. Higher initial procedure costs for MIS were largely offset by decreased nonoperative care costs over a 5-year time horizon. Optimizing effective resource use in both nonoperative and operative patients will facilitate cost-effective health care delivery. The impact of SI joint disruption on direct and indirect costs to commercial insurers, health plan beneficiaries, and employers warrants further consideration. Keywords: epidural injection, iFuse, economic model, sacroiliac joint fusion, sacroiliac joint pain, insurance

Ackerman SJ

2014-05-01

253

C-reactive protein in degenerative aortic valve stenosis  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Degenerative aortic valve stenosis includes a range of disorder severity from mild leaflet thickening without valve obstruction, "aortic sclerosis", to severe calcified aortic stenosis. It is a slowly progressive active process of valve modification similar to atherosclerosis for cardiovascular risk factors, lipoprotein deposition, chronic inflammation, and calcification. Systemic signs of inflammation, as wall and serum C-reactive protein, similar to those found in atherosclerosis, are present in patients with degenerative aortic valve stenosis and may be expression of a common disease, useful in monitoring of stenosis progression.

Mazzone AnnaMaria

2006-06-01

254

MRI of cystic collection of the three joint  

International Nuclear Information System (INIS)

We present the main MR features of cystic lesions around the knee joint. Popliteal cysts are the most frequently seen. The usually result from extrusion of joint fluid into the gastrocnemio-semimembranosus bursa but they can have an atypical location or extension. They are most often due to a meniscal, ligamentous, degenerative or inflammatory joint disease responsible for a chronic joint effusion. Meniscal cysts are always associated with a horizontal tear. Medial meniscal cysts are larger and can extend far from the joint. Bursitis occur as a result of inflammation or infection of a bursa. Their location is stereotyped and they do not communicate with the knee joint. Ganglion cysts or ganglia are benign cystic lesions which can affect peri-articular tissues as well as subchondral bone or cruciate ligaments. MRI is now a simple and noninvasive way of obtaining etiologic diagnosis and guiding therapy. (authors)

1997-01-01

255

MRI of the temporomandibular joint. Technique, results, indications  

International Nuclear Information System (INIS)

An optimized examination protocol for the MRI evaluation of the temporomandibular joint (TMJ) is presented. The MRI protocol is based on an optimized coil technology, sequence design, and a programmed examination protocol for diagnostics of the TMJ. Depending on the clinical findings, MRI provides an all-in-one diagnostic protocol for the diagnosis of degenerative, inflammatory and tumorous lesions of the TMJ. MRI using an optimized examination protocol should become the primary examination protocol for diseases of the TMJ. (orig.)

2001-11-01

256

Quantitative scintigraphy of the sacroiliac joints and spinal column in Bechterev's disease (spondylitis ankylopoetica)  

International Nuclear Information System (INIS)

Quantitative scintigraphy of the sacroiliac joints and the spinal column was performed in 138 patients with verified Bechterev's disease and in a control group of 104 healthy subjects, who had no clinical, roentgenographic and laboratory evidence of illness of the sacroiliac joints and the spinal column. By comparing skeletal ''zones of interest'' the author studied the following quantitative parameters: sacroiliac index (separately fop the right and left sacpoiliac joint); C7/sacrum jndex; D10/sacrum and L4/sacrum indices. The main values of these indices in the control group were accordingly 114.5 and 113.7 (for the right and left sacroiliac joints); 59; 95; 90. In patients with Bechterev's disease these indices were raised: 154 and 149 (for right and left sacroiliac joints); 75; 123; 113. Peak diagnostic value have the sacroiliac indices and the D10/sacrum, index, which appeared to be elevated in more than 95 per cent of the tested patients with verified Bechterev's disease. (author)

1982-01-01

257

Multiple Bone and Joint Diseases in a Nigerian Sickle Cell Anaemia: a Case Report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This case highlights the fact that bone involvement is the commonest clinical manifestation of Sickle Cell Disease (SCD) both in the acute settings such as painful vaso-occlusive crisis (VOC) and as a source of chronic, progressive debility such as avascular necrosis (AVN), chronic osteomyelitis and fixed flexion deformity of joints.

2012-01-01

258

Bone erosion of the sternocostal joint in a patient with Behcet's disease.  

Science.gov (United States)

Behcet's disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic course and unknown cause. Erosive arthropathy is extremely rare. We report a 52-year-old female patient with BD demonstrating bone erosion of the sternocostal joint. PMID:19564715

Nanke, Yuki; Kobashigawa, Tsuyoshi; Yago, Toru; Ichikawa, Naomi; Yamanaka, Hisashi; Kotake, Shigeru

2009-06-01

259

Incidence of Yersinia enterocolitica antibodies in patients with inflammatory joint diseases.  

Science.gov (United States)

Agglutinating antibodies against Yersinia enterocolitica serotypes 0:3, 0:8 and, to a minor extent, 0:6 were found in 18 out of 93 patients with inflammatory joint diseases. Patients with undifferentiated arthritis showed the highest prevalence of antibodies against Yersinia enterocolitica. The possibility that serotypes other than 0:3 may be involved in triggering arthritis is discussed. PMID:8258235

Tamburrino, V; Monno, R; Valenza, M A; Numo, R

1993-09-01

260

Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Most MRI studies of Alzheimer's disease (AD) and frontotemporal dementia (FTD) have assessed structural, perfusion and diffusion abnormalities separately while ignoring the relationships across imaging modalities. This paper aimed to assess brain gray (GM) and white matter (WM) abnormalities jointly to elucidate differences in abnormal MRI patterns between the diseases. Twenty AD, 20 FTD patients, and 21 healthy control subjects were imaged using a 4?Tesla MRI. GM loss and GM hypoperfusion ...

Zhang, Yu; Schuff, Norbert; Ching, Christopher; Tosun, Duygu; Zhan, Wang; Nezamzadeh, Marzieh; Rosen, Howard J.; Kramer, Joel H.; Gorno-tempini, Maria Luisa; Miller, Bruce L.; Weiner, Michael W.

2011-01-01

 
 
 
 
261

Coronary Artery Disease: A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender  

Digital Repository Infrastructure Vision for European Research (DRIVER)

An inverse relationship between birth weight and coronary artery diseases is well documented but it remains unclear which exposure in early life might underlie such association. Recently it has been reported an association between adenosine deaminase genetic polymorphism and coronary artery diseases. Gender differences in the degree of this association have been also observed. These observations prompted us to study the possible joint effects of BW, ADA, and gender on the susceptibility to...

Gloria-bottini, F.; Banci, M.; Saccucci, P.; Lucarini, N.; Ianniello, F.; Paradisi, G.; Magrini, A.; Bottini, E.

2009-01-01

262

Radiopharmaceuticals for SPECT exploration of dopaminergic systems. Diagnosis and surveillance of neuro-degenerative diseases; Les radiopharmaceutiques pour l`exploration des system dopaminergique en TEMP. Interet pour le diagnostic et le suivi des maladies neurodegeneratives  

Energy Technology Data Exchange (ETDEWEB)

New radiopharmaceuticals were developed to explore the pre- or post-synaptic slopes of the dopaminergic terminations. At present, their interest is recognized for the differential diagnosis of the extra-pyramidal syndromes. Other various applications in neurology and psychiatry are in view. On the pre-synaptic slope, implied in the Parkinson`s disease, the dopamine carrier, able to be visualized due to its iodine derivatives of cocaine, is localized. The {beta}CIT, which is presently the best known specificity-free derivative, has actually an equivalent affinity for the dopamine carrier and the serotonin carrier. Besides, its kinetic does not allow its imaging in the day of injection. We have developed and validated another derivative, the PE2I: N-(3-Iodoprop-(2E)-enyl) -2{beta}-carbometoxy -3{beta}-(4`-methyl-phenyl) nortropane which displays the properties required by kinetic and specificity. On the post-synaptic slope the type-D2 dopaminergic receptors were localized, which can be explored by means of (iodolisuride) ergolenes and benzamide derivatives (IBZM). These ligands have not an AMM yet, therefore their utilization may be approached by magistral preparation. The scintigraphy of the D2 receptors and dopamine carrier could be useful for the earlier diagnosis and the therapeutic surveillance of the neuro-degenerative decease. The coupling of the pre- and post-synaptic scintigraphies may be taken into consideration to augment diagnosis potentiality

Gouilloteau, D.; Prunier-Levallon, C.; Zimmer, L.; Autret, A.; Besnard, J-Cl.; Baulieu, J-L. [CHU TOURS (France)

1997-12-31

263

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 7: Lumbar fusion for intractable low-back pain without stenosis or spondylolisthesis.  

Science.gov (United States)

Establishing an appropriate treatment strategy for patients presenting with low-back pain, in the absence of stenosis or spondylolisthesis, remains a controversial subject. Inherent to this situation is often an inability to adequately identify the source of low-back pain to justify various treatment recommendations, such as lumbar fusion. The current evidence does not identify a single best treatment alternative for these patients. Based on a number of prospective, randomized trials, comparable outcomes, for patients presenting with 1- or 2-level degenerative disc disease, have been demonstrated following either lumbar fusion or a comprehensive rehabilitation program with a cognitive element. Limited access to such comprehensive rehabilitative programs may prove problematic when pursuing this alternative. For patients whose pain is refractory to conservative care, lumbar fusion is recommended. Limitations of these studies preclude the ability to present the most robust recommendation in support of lumbar fusion. A number of lesser-quality studies, primarily case series, also support the use of lumbar fusion in this patient population. PMID:24980584

Eck, Jason C; Sharan, Alok; Ghogawala, Zoher; Resnick, Daniel K; Watters, William C; Mummaneni, Praveen V; Dailey, Andrew T; Choudhri, Tanvir F; Groff, Michael W; Wang, Jeffrey C; Dhall, Sanjay S; Kaiser, Michael G

2014-07-01

264

Avaliação dos resultados clínicos após cirurgia descompressiva em cães com doença de disco intervertebral / Evaluation of clinical results of decompressive surgery in dogs with degenerative disk disease  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Avaliaram-se os resultados clínicos após realização de cirurgia descompressiva em 45 cães com doença do disco intervertebral cervical ou toracolombar. Após a cirurgia, 35 cães (77,8%) recuperaram-se totalmente, oito (17,8%) parcialmente e dois (4,4%) não apresentaram alteração do quadro inicial. Em [...] oito cães com paraplegia e perda da sensibilidade dolorosa profunda houve completa melhora do quadro clínico, com recuperação total em 62,5% dos casos. Em quatro cães com tetraparesia, a cirurgia foi eficaz. A cirurgia descompressiva (slot cervical e hemilaminectomia toracolombar), com a retirada do material do disco do interior do canal vertebral, foi uma forma efetiva de gerar melhora do quadro funcional. Abstract in english Clinical results after decompressive surgery were evaluated in 45 dogs with cervical or thoracolumbar intervertebral disk disease. After surgery, 35 dogs recovered totally, eight (17.8%) partially, and two (4.4%) did not present any change in clinical findings. Eight dogs with paraplegy and loss of [...] deep pain perception showed improvement, with total recovering in 62.5% of cases. Surgery was effective in four dogs with tetraparesy. Decompressive surgery (cervical slot or hemilaminectomy), with removal of disk material from inside the vertebral canal, was an effective form to produce functional improvement in dogs with this disease.

Arias, M.V.B.; Nishioka, C.M.; Garcia, C.O.; Reia, A.Z.; Baraúna Júnior, D.; Marcasso, R.A..

265

Avaliação dos resultados clínicos após cirurgia descompressiva em cães com doença de disco intervertebral Evaluation of clinical results of decompressive surgery in dogs with degenerative disk disease  

Directory of Open Access Journals (Sweden)

Full Text Available Avaliaram-se os resultados clínicos após realização de cirurgia descompressiva em 45 cães com doença do disco intervertebral cervical ou toracolombar. Após a cirurgia, 35 cães (77,8% recuperaram-se totalmente, oito (17,8% parcialmente e dois (4,4% não apresentaram alteração do quadro inicial. Em oito cães com paraplegia e perda da sensibilidade dolorosa profunda houve completa melhora do quadro clínico, com recuperação total em 62,5% dos casos. Em quatro cães com tetraparesia, a cirurgia foi eficaz. A cirurgia descompressiva (slot cervical e hemilaminectomia toracolombar, com a retirada do material do disco do interior do canal vertebral, foi uma forma efetiva de gerar melhora do quadro funcional.Clinical results after decompressive surgery were evaluated in 45 dogs with cervical or thoracolumbar intervertebral disk disease. After surgery, 35 dogs recovered totally, eight (17.8% partially, and two (4.4% did not present any change in clinical findings. Eight dogs with paraplegy and loss of deep pain perception showed improvement, with total recovering in 62.5% of cases. Surgery was effective in four dogs with tetraparesy. Decompressive surgery (cervical slot or hemilaminectomy, with removal of disk material from inside the vertebral canal, was an effective form to produce functional improvement in dogs with this disease.

M.V.B. Arias

2007-12-01

266

Parainflammation associated with advanced glycation endproduct stimulation of RPE in vitro: implications for age-related degenerative diseases of the eye.  

Science.gov (United States)

Age related macular degeneration (AMD) is one of the leading causes of blindness in Western society. A hallmark of early stage AMD are drusen, extracellular deposits that accumulate in the outer retina. Advanced glycation endproducts (AGE) accumulate with aging and are linked to several age-related diseases such as Alzheimer's disease, osteoarthritis, atherosclerosis and AMD. AGE deposits are found in drusen and in Bruch's membrane of the eye and several studies have suggested its role in promoting oxidative stress, apoptosis and lipofuscin accumulation. Recently, complement activation and chronic inflammation have been implicated in the pathogenesis of AMD. While AGEs have been shown to promote inflammation in other diseases, whether it plays a similar role in AMD is not known. This study investigates the effects of AGE stimulation on pro- and anti-inflammatory pathways in primary culture of human retinal pigment epithelial cells (RPE). Differential gene expression studies revealed a total of 41 up- and 18 down-regulated RPE genes in response to AGE stimulation. These genes fell into three categories as assessed by gene set enrichment analysis (GSEA). The main categories were inflammation (interferon-induced, immune response) and proteasome degradation, followed by caspase signaling. Using suspension array technology, protein levels of secreted cytokines and growth factors were also examined. Anti-inflammatory cytokines including IL10, IL1ra and IL9 were all overexpressed. Pro-inflammatory cytokines including IL4, IL15 and IFN-? were overexpressed, while other pro-inflammatory cytokines including IL8, MCP1, IP10 were underexpressed after AGE stimulation, suggesting a para-inflammation state of the RPE under these conditions. Levels of mRNA of chemokine, CXCL11, and viperin, RSAD2, were up-regulated and may play a role in driving the inflammatory response via the NF-kB and JAK-STAT pathways. CXCL11 was strongly immunoreactive and associated with drusen in the AMD eye. The pathways and novel genes identified here highlight inflammation as a key response to AGE stimulation in primary culture of human RPE, and identify chemokine CXCL11 as putative novel agent associated with the pathogenesis of AMD. PMID:23601964

Lin, Tony; Walker, Gregory Brett; Kurji, Khaliq; Fang, Edward; Law, Geoffrey; Prasad, Shiv S; Kojic, Luba; Cao, Sijia; White, Valerie; Cui, Jing Z; Matsubara, Joanne A

2013-06-01

267

Treatment of post-traumatic degenerative changes of the radio-carpal and distal radio-ulnar joints by combining radius, scaphoid, and lunate (RSL) fusion with ulnar head replacement  

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Distal radial fractures are a common type of fracture. In the case of intra-articular fractures, they often result in post-traumatic arthrosis. The objective of this study is to describe a novel alternative to the established salvage techniques for the treatment of post-traumatic arthrosis of the radio-carpal and distal radio-ulnar joints (DRUJ). Six patients with radio-carpal and DRUJ arthrosis were treated with a combined radius, scaphoid, and lunate (RSL) arthrodesis and as a Herbert ulnar...

Groningen, Jorg Melcher; Schuurman, Arnold H.

2011-01-01

268

Joint principles of motor and cognitive dysfunction in Parkinson's disease.  

Science.gov (United States)

Traditionally, the lateral premotor cortex (PM) is assigned a role in stimulus-driven rather than memory-driven motor control, whereas the opposite holds for the mesial premotor cortex (supplementary motor area, SMA). Consistently, patients with Parkinson's Disease (PD), in which a specific functional degradation of the mesial loop (i.e., SMA-Striatum) occurs, show impaired memory-driven but relatively preserved stimulus-driven motor control. However, both parts of the premotor cortex are involved in perceptual prediction tasks as well. Here we tested whether the functional bias described on the motor level (i.e., memory-driven/mesial versus stimulus-driven/lateral) can also be detected in perceptual prediction tasks thereby suggesting that PD patients exhibit the same pattern of impaired memory-driven and preserved stimulus-driven control in the cognitive domain. To this end, we investigated 20 male PD-patients "on" and "off" dopaminergic medication while performing a serial prediction task (SPT). A specific modification was implemented to the classical SPT (SPT0) that caused shifts from stimulus- to memory-based prediction (SPT+). As a result, PD patients showed a significantly impaired performance "off" compared to "on" medication for SPT+, whereas no significant "on"/"off"-effects were found for SPT0. Descriptively, the "off"-performance decreased gradually with increasing demands on memory-based prediction. Furthermore, the severity of motor deficits according to the UPDRS III correlated significantly with impaired performance in SPT0 "on" medication. Importantly, an even stronger dependency was found for UPDRS III and SPT+. These findings point to a role of the SMA-striatal loop in memory-driven serial prediction beyond the motor domain. PMID:23628367

Schönberger, Anna R; Barbe, Michael T; Hagelweide, Klara; Kühn, Anne B; Fink, Gereon R; Schubotz, Ricarda I

2013-07-01

269

Heart rate variability and arrhythmias evaluated with Holter in dogs with degenerative mitral valve disease / Variabilidade da frequência cardíaca e arritmias detectadas pelo exame Holter em cães com degeneração valvar mitral  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese As cardiopatias cursam com alterações do controle autonômico do coração, resultando em taquicardia e consequente diminuição na variabilidade da frequência cardíaca (VFC). O objetivo deste estudo foi avaliar se o desenvolvimento de insuficiência cardíaca secundária à degeneração valvar mitral (DVM) l [...] eva a alterações no controle autonômico do coração, as quais podem ser determinadas pela eletrocardiografia contínua (Holter). Cães foram distribuídos em grupos experimentais após avaliação clínica e ecocardiográfica da seguinte maneira: controle (saudáveis; n=6), DVM sem insuficiência cardíaca (n=8) e DVM com insuficiência cardíaca (n=13). Arritmias e VFC foram determinadas pelo Holter. Animais portadores de DVM, quando comparados ao controle, apresentaram diminuição significativa da potência total, a qual é representativa de toda a VFC. Somente cães doentes e com insuficiência cardíaca apresentaram incidência elevada de arritmias supraventriculares, frequência cardíaca aumentada, pequena quantidade de pausas superiores a 2,0s entre batimentos consecutivos, permanência por mais tempo em taquicardia do que em bradicardia, diminuído índice de alta frequência (indicativo de controle parassimpático) e elevado índice de baixa frequência (indicativo de controle simpático e parassimpático), quando comparados ao controle (p Abstract in english Cardiac diseases promote alterations in the autonomic control of the heart, leading to an increase in heart rate and, as a result, a decrease in heart rate variability (HRV).The aim of this study was to evaluate if the development of heart failure secondary to degenerative mitral valve disease (DMVD [...] ) concurs with changes in autonomic modulation of heart rhythm which are assessed by long electrocardiography examination (Holter). Dogs were evaluated by clinical examination and echocardiography in order to be categorized into the following groups: Control (healthy; n=6), DMVD (disease without heart failure; n=8), and DMVD heart failure (disease with heart failure; n=13). Arrhythmias and frequency domain HRV were determined by Holter. Diseased animals, when compared to healthy, had significantly lower total power, which indicates overall HRV. DMVD heart failure dogs also showed other disturbances such as high incidence of supraventricular arrhythmias, high heart rate, little amount of pauses (2.0s long between consecutive heartbeats), longer time in tachycardia, shorter time in bradycardia, low high frequency (parasympathetic control), and high low frequency (sympathetic and parasympathetic control) when compared to control (p

M.S., Oliveira; R.A.L., Muzzi; R.B., Araújo; L.A.L., Muzzi; D.F., Ferreira; E.F., Silva.

270

Lessons from a non-domestic canid: joint disease in captive raccoon dogs (Nyctereutes procyonoides  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of this study was to describe pathological changes of the shoulder, elbow, hip and stifle joints of 16 museum skeletons of the raccoon dog (Nyctereutes procyonoides. The subjects had been held in long-term captivity and were probably used for fur farming or research, thus allowing sufficient longevity for joint disease to become recognisable. The prevalence of disorders that include osteochondrosis, osteoarthritis and changes compatible with hip dysplasia, was surprisingly high. Other changes that reflect near-normal or mild pathological conditions, including prominent articular margins and mild bony periarticular rim, were also prevalent. Our data form a basis for comparing joint pathology of captive raccoon dogs with other mammals and also suggest that contributing roles of captivity and genetic predisposition should be explored further in non-domestic canids.

Dennis F. Lawler

2012-12-01

271

Joint association discovery and diagnosis of Alzheimer's disease by supervised heterogeneous multiview learning.  

Science.gov (United States)

A key step for Alzheimer's disease (AD) study is to identify associations between genetic variations and intermediate phenotypes (e.g., brain structures). At the same time, it is crucial to develop a noninvasive means for AD diagnosis. Although these two tasks-association discovery and disease diagnosis-have been treated separately by a variety of approaches, they are tightly coupled due to their common biological basis. We hypothesize that the two tasks can potentially benefit each other by a joint analysis, because (i) the association study discovers correlated biomarkers from different data sources, which may help improve diagnosis accuracy, and (ii) the disease status may help identify disease-sensitive associations between genetic variations and MRI features. Based on this hypothesis, we present a new sparse Bayesian approach for joint association study and disease diagnosis. In this approach, common latent features are extracted from different data sources based on sparse projection matrices and used to predict multiple disease severity levels based on Gaussian process ordinal regression; in return, the disease status is used to guide the discovery of relationships between the data sources. The sparse projection matrices not only reveal the associations but also select groups of biomarkers related to AD. To learn the model from data, we develop an efficient variational expectation maximization algorithm. Simulation results demonstrate that our approach achieves higher accuracy in both predicting ordinal labels and discovering associations between data sources than alternative methods. We apply our approach to an imaging genetics dataset of AD. Our joint analysis approach not only identifies meaningful and interesting associations between genetic variations, brain structures, and AD status, but also achieves significantly higher accuracy for predicting ordinal AD stages than the competing methods. PMID:24297556

Zhe, Shandian; Xu, Zenglin; Qi, Yuan; Yu, Peng

2014-01-01

272

Joint Hypermobility Syndrome and Dysautonomia: Expanding Spectrum of Disease Presentation and Manifestation  

Directory of Open Access Journals (Sweden)

Full Text Available The varying clinical presentations of not so well recognized diseases, which continue to haunt patients is well described in the above quotes. Clinicians may not recognize associated subtle early presentations of the disease, till the disease has fully manifested itself. Of all the disorders of human body, autonomic syndromes are still the least understood. Presentation and association of autonomic diseases with other disorders may be so varied and subtle that clinicians may fail to recognize autonomic disturbance as an individual clinical entity within the disease and therefore appropriate management still remains inadequate. Similar association between joint hypermobility disorder, in which postural orthostatic tachycardia syndrome and dysautonomia is increasingly being recognized as an associated clinical entity, has been further elaborated.

Shomu Bohora

2010-04-01

273

Osteomyelitis of the hip joint associated with systemic cat-scratch disease in an adult.  

Science.gov (United States)

Reported here is the case of a 29-year-old male with cervical lymphadenopathy, fever and weight loss, followed by acute painful osteomyelitis of the left hip joint due to cat-scratch disease. The diagnosis was established by detection of IgG antibodies to Bartonella henselae in serum and histologic examination of a lymph node including a positive polymerase chain reaction test. Treatment consisted of clarithromycin and cefotiam for 2 weeks. Four weeks after discharge, all of the patient's symptoms had completely resolved. Magnetic resonance imaging of the left hip joint showed marked regression of bone inflammation 4 months later and normalization after 8 months. Cat-scratch disease should be considered in the differential diagnosis of osteomyelitis in an adult, especially when lymphadenitis is present. PMID:11117643

Krause, R; Wenisch, C; Fladerer, P; Daxböck, F; Krejs, G J; Reisinger, E C

2000-10-01

274

Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint – FNA findings and microanalysis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract We report a case of a Calcium pyrophosphate dihydrate deposition disease (CPPD) presenting as a mass in the parotid and temporomandibular joint (TMJ) that simulated a parotid tumor. A 35 year-old man presented with pain in the left ear area. A CT Scan of the area showed a large, calcified mass surrounding the left condylar head, and extending into the infratemporal fossa. FNA of the mass showed birefringent crystals, most of which were rhomboid with occasional ones being ne...

2008-01-01

275

Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint – FNA findings and microanalysis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We report a case of a Calcium pyrophosphate dihydrate deposition disease (CPPD) presenting as a mass in the parotid and temporomandibular joint (TMJ) that simulated a parotid tumor. A 35 year-old man presented with pain in the left ear area. A CT Scan of the area showed a large, calcified mass surrounding the left condylar head, and extending into the infratemporal fossa. FNA of the mass showed birefringent crystals, most of which were rhomboid with occasional ones being needle shaped, embedd...

2008-01-01

276

Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint - FNA findings and microanalysis.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We report a case of a Calcium pyrophosphate dihydrate deposition disease (CPPD) presenting as a mass in the parotid and temporomandibular joint (TMJ) that simulated a parotid tumor. A 35 year-old man presented with pain in the left ear area. A CT Scan of the area showed a large, calcified mass surrounding the left condylar head, and extending into the infratemporal fossa. FNA of the mass showed birefringent crystals, most of which were rhomboid with occasional ones being needle shaped, embedd...

2008-01-01

277

Calcium pyrophosphate dihydrate crystal deposition disease presenting as a pseudotumor of the temporomandibular joint  

Energy Technology Data Exchange (ETDEWEB)

We report a case of a 66-year-old white woman with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease. The patient related a 2-month history of swelling with tenderness over the left pre-auricular region. A CT scan suggested a synovial chondromatosis. Surgical removal was done and histologic study showed CPPD crystals. This disease rarely involves the temporomandibular joint (TMJ) and is not usually considered in the differential diagnosis. To our knowledge, only 14 cases have been reported in the literature. (orig.) With 3 figs., 10 refs.

Vargas, A.; Teruel, J.; Pont, J.; Velayos, A. [Department of Radiology, Hospital de Girona ``Dr. Josep Trueta``, Av. de Franca s/n, E-17 007 Girona (Spain); Trull, J. [Department of Oral Surgery, Hospital de Girona, Dr. ``Josep Trueta``, Av. de Franca s/n, E-17 007 Girona (Spain); Lopez, E. [Department of Pathology, Hospital de Girona, Dr. ``Josep Trueta``, Av. de Franca s/n, E-17 007 Girona (Spain)

1997-12-01

278

Calcium pyrophosphate dihydrate crystal deposition disease presenting as a pseudotumor of the temporomandibular joint  

International Nuclear Information System (INIS)

We report a case of a 66-year-old white woman with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease. The patient related a 2-month history of swelling with tenderness over the left pre-auricular region. A CT scan suggested a synovial chondromatosis. Surgical removal was done and histologic study showed CPPD crystals. This disease rarely involves the temporomandibular joint (TMJ) and is not usually considered in the differential diagnosis. To our knowledge, only 14 cases have been reported in the literature. (orig.)

1997-12-01

279

Joint disease, the hallmark of haemophilia: what issues and challenges remain despite the development of effective therapies?  

Science.gov (United States)

Although effective therapies for haemophilia have been available for decades, the prevention and treatment of joint disease remain major clinical concerns for all haemophilia patients. Early identification of joint disease is vital to initiate or modify treatment, and prevent arthropathy. However, there remains a need for more sensitive and accurate methods, which may also detect improvement in patient outcome with new therapies or different prophylaxis regimens. These topics were explored at the Ninth Zürich Haemophilia Forum. A summary of our shared views on the limitations of current assessment methods, and the potential advantages of more recently developed tools, is provided. Ultrasonography enables more frequent routine monitoring and the early detection of joint disease. In addition, serological markers may provide suitable biomarkers of early arthropathy. To prevent arthropathy, in our opinion, prophylaxis is key to prevent joint bleeds and subsequent initiation of the 'vicious circle of joint disease'. However, issues remain, including when prophylaxis should be started, stopped, and if it is efficacious for inhibitor patients. Once joint bleeding has occurred, enhanced on-demand treatment should be considered. For more advanced stages of joint disease, the issues regarding the treatment options available are explored. Radiosynovectomy should be performed to treat chronic synovitis, and may prevent the need for elective orthopaedic surgery (EOS). Ultimately, however, EOS can be considered once all other treatment options have been explored. While, bypassing agents have facilitated the use of EOS in inhibitor patients, a multidisciplinary approach and careful surveillance is required for good patient outcome. PMID:24613700

Lambert, Thierry; Auerswald, Günter; Benson, Gary; Hedner, Ulla; Jiménez-Yuste, Victor; Ljung, Rolf; Morfini, Massimo; Remor, Eduardo; Santagostino, Elena; Zupan?i? Šalek, Silva

2014-06-01

280

Obesity and increased burden of hip and knee joint disease in Australia: Results from a national survey  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Research involving more representative samples is needed to extend our understanding of the broader impact of obesity in hip or knee joint disease (arthritis and OA) beyond clinical settings. Although population-based research has been conducted in the United States, how these findings translate to other countries is unclear. Using a national approach, this study explored associations between obesity and the burden of hip and knee joint disease in Australi...

Ackerman Ilana N; Osborne Richard H

2012-01-01

 
 
 
 
281

Treatment of Joint Inflammatory Diseases in the Lame Backyard Chickens with NSAIDs  

Directory of Open Access Journals (Sweden)

Full Text Available The effects of several Non-Steroidal Anti-Inflammatory Drugs (NSAIDs were determined in 200 mature backyard chickens with clinical signs of lameness. The NSAIDs, diclofenac, carprofen, ketoprofen and meloxicam with doses 0.5, 1, 2, 3 and 4 mg/kg were used in these groups, orally. Chickens were monitored on a daily basis for general condition, joint inflammation reduction and mortality. Diclofenac, carprofen and ketoprofen were associated with mortality. In contrast, there were no reported mortalities for the NSAID, meloxicam in this study. Results of the current study revealed that the meloxicam was the drug of choice with relative safety for treatment of joint inflammatory diseases in chickens.

M.M. Hadipour

2011-04-01

282

MRI of cystic collection of the three joint; Les collections kystiques du genou en IRM  

Energy Technology Data Exchange (ETDEWEB)

We present the main MR features of cystic lesions around the knee joint. Popliteal cysts are the most frequently seen. The usually result from extrusion of joint fluid into the gastrocnemio-semimembranosus bursa but they can have an atypical location or extension. They are most often due to a meniscal, ligamentous, degenerative or inflammatory joint disease responsible for a chronic joint effusion. Meniscal cysts are always associated with a horizontal tear. Medial meniscal cysts are larger and can extend far from the joint. Bursitis occur as a result of inflammation or infection of a bursa. Their location is stereotyped and they do not communicate with the knee joint. Ganglion cysts or ganglia are benign cystic lesions which can affect peri-articular tissues as well as subchondral bone or cruciate ligaments. MRI is now a simple and noninvasive way of obtaining etiologic diagnosis and guiding therapy. (authors). 46 refs.

Boutry, N.; Cotten, A.; Dewatre, F.; Chastanet, P.; Gougeon, F. [Hopital R. Salengro, C.H.U., 59 - Lille (France)

1997-09-01

283

[Arthrosonography as a method to assess the degenerative and inflammatory components of knee osteoarthrosis].  

Science.gov (United States)

Ultrasound examination of the knee joints was performed in 254 patients with Kellgren-Lawrence I to III stage osteoarthrosis using Aloha Pro Sound 5500 device (Japan) and Philips Envision device with 7.5 to 12 MHz linear sensors. Bone contours, the height of the cartilage, the degree of the marginal osteophytosis, the structure of periarticular formations--the bursae, the tendons and their vaginas--as well as the presence and the quantity of articular excaudate, the thickness and changes in the synovian membrane, were evaluated. The degree of marginal osteophytosis detected by ultrasonography in manifest osteoarthrosis was in a direct correlation with the radiological picture. A decrease in cartilage height is an ultrasonographic sign of osteoarthrosis, while detailed evaluation of the stage of the degenerative process using ultrasonography should be based upon the revealing and evaluation of osteophytosis. An increase in the thickness of the knee joint synovian membrane by more than 2 mm according to ultrasound examination in case of prolonged secondary synoviitis evidences both the presence of an inflammatory process and the length of the osteoarthritic disease. PMID:18318167

Krasivina, I G; Dolgova, L N; Sencha, A N; Beliaev, D V; Lavrukhina, A A

2007-01-01

284

Classificação diagnóstica dos portadores de doenças degenerativas de retina, integrantes dos grupos Retina São Paulo e Retina Vale do Paraíba Diagnostic classification of retinal degenerative diseases São Paulo and Vale Retina groups  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVO:Organizar um banco de dados regional de todos os indivíduos portadores de doenças degenerativas da retina, com o objetivo de classificar cada paciente de acordo com o tipo de distrofia e padrão de herança. MÉTODOS: Durante o encontro do Grupo Retina São Paulo no dia 5 de maio de 2001, duzentas e quarenta e três pessoas foram registradas, sendo que parte forneceu dados de antecedentes oculares, pessoais e familiares e árvore genealógica. Noventa e três pacientes foram questionados quanto a idade, origem, tipo de distrofia, história familiar e árvore genealógica, tipo de herança, outras anomalias sistêmicas e exames complementares. Foram classificados quanto ao diagnóstico e padrão de herança. RESULTADOS: Dos duzentos e quarenta e três pacientes registrados, as distrofias encontradas foram retinose pigmentária, doença de Stargardt, síndrome de Usher, amaurose congênita de Leber e coroideremia. Quanto à divisão por doença dos 93 pacientes argüidos, havia 62 pacientes com retinose pigmentária, 13 com doença de Stargardt, 13 com síndrome de Usher, três com amaurose congênita de Leber e dois com coroideremia. Dos pacientes com retinose pigmentária, o padrão de herança detectado foi autossômico dominante em quatro casos (7%, autossômico recessivo em vinte casos (32%, ligado ao cromossomo X recessivo em sete casos (11%, caso isolado em vinte e nove (47% e padrão indeterminado em dois (3%. Para a doença de Stargardt três indivíduos (23% seguiam o padrão de herança autossômico recessivo e dez (77% eram casos isolados. Dos treze pacientes com síndrome de Usher, oito (61,5% apresentavam herança autossômica recessiva, quatro (31% eram casos isolados e um (7,5% tinha o padrão de herança indeterminado. Os dois pacientes com coroideremia seguiam o padrão de herança ligado ao X recessivo. Para amaurose congênita de Leber, um paciente (33,5% tinha padrão autossômico recessivo de herança e dois (66,5% eram casos isolados. CONCLUSÃO: Destaca-se assim a importância desta classificação como a primeira referência nacional dos padrões de hereditariedade das distrofias retinianas do país. Este é o primeiro passo para se proceder em seguida a classificação genético-molecular baseada no seqüenciamento de cada gene responsável por cada um dos padrões de herança. A freqüência de cada tipo específico é semelhante à encontrada em outros trabalhos epidemiológicos de outros países.PURPOSE: To organize a regional data bank of all individuals that have retinal degenerative diseases, with the aim to classify each patient according to the type of distrophy and pattern of inheritance. METHODS: During the meeting of the São Paulo Retina Group on May 5th, 2001, two hundred and forty-three persons were registered, part of whom provided information concerning ocular, personal and family history and family tree. Ninety-three patients were asked about age, origin, type of dystrophy, family history and family tree information, type of inheritance, other systemic abnormalities and complementary examination. They were classified according to the diagnosis and pattern of inhe-ritance. RESULTS: The distrophies found in the registered two hundred and forty-three patients, were: retinitis pigmentosa, Stargardt disease, Usher syndrome, Leber congenital amaurosis and choroideremia. Of the ninety-three patients examined on the same day, sixty-two had retinitis pigmentosa, thirteen had Stargardt disease, thirteen had Usher syndrome, three had Leber congenital amaurosis and two had choroideremia. The inheritance pattern of the patients with retinitis pigmentosa was autosomal dominant in 4 cases (7%, autosomal recessive in twenty cases (32%, X-linked recessive in 7 cases (11%. Twenty-nine cases were isolated (47% and two had an indeterminate pattern of inheritance (3%. Of the Stargardt disease patients, three (23% were autosomal recessive and ten (77% were isolated cases. Of the thirteen patients with Usher syndrome, eight (61.5% were autosomal recessive, four (31% were i

Nichard Unonius

2003-08-01

285

Classificação diagnóstica dos portadores de doenças degenerativas de retina, integrantes dos grupos Retina São Paulo e Retina Vale do Paraíba / Diagnostic classification of retinal degenerative diseases São Paulo and Vale Retina groups  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO:Organizar um banco de dados regional de todos os indivíduos portadores de doenças degenerativas da retina, com o objetivo de classificar cada paciente de acordo com o tipo de distrofia e padrão de herança. MÉTODOS: Durante o encontro do Grupo Retina São Paulo no dia 5 de maio de 2001, duzen [...] tas e quarenta e três pessoas foram registradas, sendo que parte forneceu dados de antecedentes oculares, pessoais e familiares e árvore genealógica. Noventa e três pacientes foram questionados quanto a idade, origem, tipo de distrofia, história familiar e árvore genealógica, tipo de herança, outras anomalias sistêmicas e exames complementares. Foram classificados quanto ao diagnóstico e padrão de herança. RESULTADOS: Dos duzentos e quarenta e três pacientes registrados, as distrofias encontradas foram retinose pigmentária, doença de Stargardt, síndrome de Usher, amaurose congênita de Leber e coroideremia. Quanto à divisão por doença dos 93 pacientes argüidos, havia 62 pacientes com retinose pigmentária, 13 com doença de Stargardt, 13 com síndrome de Usher, três com amaurose congênita de Leber e dois com coroideremia. Dos pacientes com retinose pigmentária, o padrão de herança detectado foi autossômico dominante em quatro casos (7%), autossômico recessivo em vinte casos (32%), ligado ao cromossomo X recessivo em sete casos (11%), caso isolado em vinte e nove (47%) e padrão indeterminado em dois (3%). Para a doença de Stargardt três indivíduos (23%) seguiam o padrão de herança autossômico recessivo e dez (77%) eram casos isolados. Dos treze pacientes com síndrome de Usher, oito (61,5%) apresentavam herança autossômica recessiva, quatro (31%) eram casos isolados e um (7,5%) tinha o padrão de herança indeterminado. Os dois pacientes com coroideremia seguiam o padrão de herança ligado ao X recessivo. Para amaurose congênita de Leber, um paciente (33,5%) tinha padrão autossômico recessivo de herança e dois (66,5%) eram casos isolados. CONCLUSÃO: Destaca-se assim a importância desta classificação como a primeira referência nacional dos padrões de hereditariedade das distrofias retinianas do país. Este é o primeiro passo para se proceder em seguida a classificação genético-molecular baseada no seqüenciamento de cada gene responsável por cada um dos padrões de herança. A freqüência de cada tipo específico é semelhante à encontrada em outros trabalhos epidemiológicos de outros países. Abstract in english PURPOSE: To organize a regional data bank of all individuals that have retinal degenerative diseases, with the aim to classify each patient according to the type of distrophy and pattern of inheritance. METHODS: During the meeting of the São Paulo Retina Group on May 5th, 2001, two hundred and forty [...] -three persons were registered, part of whom provided information concerning ocular, personal and family history and family tree. Ninety-three patients were asked about age, origin, type of dystrophy, family history and family tree information, type of inheritance, other systemic abnormalities and complementary examination. They were classified according to the diagnosis and pattern of inhe-ritance. RESULTS: The distrophies found in the registered two hundred and forty-three patients, were: retinitis pigmentosa, Stargardt disease, Usher syndrome, Leber congenital amaurosis and choroideremia. Of the ninety-three patients examined on the same day, sixty-two had retinitis pigmentosa, thirteen had Stargardt disease, thirteen had Usher syndrome, three had Leber congenital amaurosis and two had choroideremia. The inheritance pattern of the patients with retinitis pigmentosa was autosomal dominant in 4 cases (7%), autosomal recessive in twenty cases (32%), X-linked recessive in 7 cases (11%). Twenty-nine cases were isolated (47%) and two had an indeterminate pattern of inheritance (3%). Of the Stargardt disease patients, three (23%) were autosomal recessive and ten (77%) were iso

Unonius, Nichard; Farah, Michel Eid; Sallum, Juliana M. Ferraz.

286

Massive calcium pyrophosphate dihydrate crystal deposition disease: a cause of pain of the temporomandibular joint.  

Science.gov (United States)

Calcium pyrophosphate dihydrate deposition (CPDD) disease is a disorder that occasionally affects the temporomandibular joint (TMJ) and temporal bone, causing pain (66.6% of cases), swelling (50%), trismus (36.8%), and hearing loss (22.2%). Diagnosis of CPDD is challenging because clinical symptoms and imaging features are not characteristic and may mimic a chondrosarcoma. When the diagnosis of CPDD of the TMJ is under consideration, conventional radiographs of the wrist or the knee may contribute to the final diagnosis. Imaging features of CPDD are discussed with a review of the literature. PMID:15140740

Marsot-Dupuch, Kathlyn; Smoker, Wendy R K; Gentry, Lindell R; Cooper, Karen A

2004-05-01

287

[Carpal instability and secondary degenerative changes in lesions of the radio-carpal ligaments with various etiology].  

Science.gov (United States)

Rotational subluxation of the scaphoid (RSS) and ulnar translocation of the carpus (UT) result from distinct lesions of the radiocarpal ligament complex. Trauma, rheumatoid arthritis, calcium pyrophosphate dihydrate crystal deposition (CPDD) and neurologic disease can lead to this ligament defect. The radiological features are identical despite different etiologies of the ligament failure. The secondary degenerative changes in RSS develop in three stages: starting with osteoarthritis at the styloid process, then progression of the degeneration into the mid-carpal joint from central towards ulnar. This mechanism is identical in posttraumatic, inflammatory, neurogenic or CPDD related instability. In cases with rheumatoid arthritis related instability, RSS and UT can be found simultaneously. The knowledge of these radiological features can be helpful in clarifying reasons for carpal changes and in determining the time of onset of the primary ligament failure. PMID:2283104

Stäbler, A; Baumeister, R G; Berger, H

1990-11-01

288

Calcium pyrophosphate dihydrate deposition disease (CPPD/Pseudogout of the temporomandibular joint - FNA findings and microanalysis.  

Directory of Open Access Journals (Sweden)

Full Text Available We report a case of a Calcium pyrophosphate dihydrate deposition disease (CPPD presenting as a mass in the parotid and temporomandibular joint (TMJ that simulated a parotid tumor. A 35 year-old man presented with pain in the left ear area. A CT Scan of the area showed a large, calcified mass surrounding the left condylar head, and extending into the infratemporal fossa. FNA of the mass showed birefringent crystals, most of which were rhomboid with occasional ones being needle shaped, embedded in an amorphous pink substance. Scanning electron microscopy (SEM with energy dispersive x-ray spectroscopy (EDS of these crystals showed peaks corresponding to calcium and phosphorus. SEM/EDS is a rapid method of diagnosing calcium pyrophosphate dihydrate deposition disease (CPPD and an alternative to more commonly used method of special staining of cell block sections coupled with polarizing microscopy.

Naqvi Asghar

2008-01-01

289

Calcium pyrophosphate dihydrate deposition disease (CPPD/Pseudogout of the temporomandibular joint – FNA findings and microanalysis  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract We report a case of a Calcium pyrophosphate dihydrate deposition disease (CPPD presenting as a mass in the parotid and temporomandibular joint (TMJ that simulated a parotid tumor. A 35 year-old man presented with pain in the left ear area. A CT Scan of the area showed a large, calcified mass surrounding the left condylar head, and extending into the infratemporal fossa. FNA of the mass showed birefringent crystals, most of which were rhomboid with occasional ones being needle shaped, embedded in an amorphous pink substance. Scanning electron microscopy (SEM with energy dispersive x-ray spectroscopy (EDS of these crystals showed peaks corresponding to calcium and phosphorus. SEM/EDS is a rapid method of diagnosing calcium pyrophosphate dihydrate deposition disease (CPPD and an alternative to more commonly used method of special staining of cell block sections coupled with polarizing microscopy.

Naqvi Asghar H

2008-04-01

290

Joint disease mapping using six cancers in the Yorkshire region of England  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Objectives The aims of this study were to model jointly the incidence rates of six smoking related cancers in the Yorkshire region of England, to explore the patterns of spatial correlation amongst them, and to estimate the relative weight of smoking and other shared risk factors for the relevant disease sites, both before and after adjustment for socioeconomic background (SEB. Methods Data on the incidence of oesophagus, stomach, pancreas, lung, kidney, and bladder cancers between 1983 and 2003 were extracted from the Northern & Yorkshire Cancer Registry database for the 532 electoral wards in the Yorkshire region. Using postcode of residence, each case was assigned an area-based measure of SEB using the Townsend index. Standardised incidence ratios (SIRs were calculated for each cancer site and their correlations investigated. The joint analysis of the spatial variation in incidence used a Bayesian shared-component model. Three components were included to represent differences in smoking (for all six sites, bodyweight/obesity (for oesophagus, pancreas and kidney cancers and diet/alcohol consumption (for oesophagus and stomach cancers. Results The incidence of cancers of the oesophagus, pancreas, kidney, and bladder was relatively evenly distributed across the region. The incidence of stomach and lung cancers was more clustered around the urban areas in the south of the region, and these two cancers were significantly associated with higher levels of area deprivation. The incidence of lung cancer was most impacted by adjustment for SEB, with the rural/urban split becoming less apparent. The component representing smoking had a larger effect on cancer incidence in the eastern part of the region. The effects of the other two components were small and disappeared after adjustment for SEB. Conclusion This study demonstrates the feasibility of joint disease modelling using data from six cancer sites. Incidence estimates are more precise than those obtained without smoothing. This methodology may be an important tool to help authorities evaluate healthcare system performance and the impact of policies.

Edwards Kimberley L

2008-07-01

291

Independent and joint effects of the MAPT and SNCA genes in Parkinson's disease  

Science.gov (United States)

Objective We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule associated protein tau (MAPT) in Parkinson's disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. Methods Participants of Caucasian ancestry were genotyped for a total of four SNCA (rs2583988, rs181489, rs356219, rs11931074) and two MAPT (rs1052553, rs242557) SNPs. Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied both on a multiplicative and an additive scale, and using a case-control and case-only approach. Results Fifteen GEO-PD sites contributed a total of 5302 cases and 4161 controls. All four SNCA SNPs and the MAPT H1-haplotype defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 3? end of the gene. There was no evidence of statistical interaction between any of the four SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale. Interpretation This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these two loci is consistent with independent effects of the genes without additional interacting effects.

Elbaz, Alexis; Ross, Owen A.; Ioannidis, John P.A.; Soto-Ortolaza, Alexandra I; Moisan, Frederic; Aasly, Jan; Annesi, Grazia; Bozi, Maria; Brighina, Laura; Chartier-Harlin, Marie-Christine; Destee, Alain; Ferrarese, Carlo; Ferraris, Alessandro; Gibson, J. Mark; Gispert, Suzana; Hadjigeorgiou, Georgios M.; Jasinska-Myga, Barbara; Klein, Christine; Kruger, Rejko; Lambert, Jean-Charles; Lohmann, Katja; van de Loo, Simone; Loriot, Marie-Anne; Lynch, Timothy; Mellick, George D.; Mutez, Eugenie; Nilsson, Christer; Opala, Grzegorz; Puschmann, Andreas; Quattrone, Aldo; Sharma, Manu; Silburn, Peter A.; Stefanis, Leonidas; Uitti, Ryan J.; Valente, Enza Maria; Vilarino-Guell, Carles; Wirdefeldt, Karin; Wszolek, Zbigniew K.; Xiromerisiou, Georgia; Maraganore, Demetrius M.; Farrer, Matthew J.

2011-01-01

292

Hip and pelvis diseases on lumbar AP radiographs including both hip joints  

Energy Technology Data Exchange (ETDEWEB)

To determine the frequency of disease, and to evaluate the methods used for lumbar spine radiography in Korea. Sixty university and training hospitals were randomly selected and asked to describe the projections, film size and radiographic techniques employed for routine radiography in patients with suspected disease of the lumbar spine. Plain radiographs of 1215 patients, taken using 14x17 inch film and depicting both hip joints and the lumbar region, were analysed between March 1999 and February 2000. In 15 patients (1.2%), the radiographs revealed hip or pelvic lesion, confirmed as follows: avascular necrosis of the femoral head (n=11, with bilateral lesion in four cases); sustained ankylosing spondylitis (n=2); acetabular dysplasia (n=1); and insufficiency fracture of the pubic rami secondary to osteoporosis (n=1). In 11 or the 20 hospitals which responded, 14{sup x}17{sup f}ilm was being used for lumbar radiography, while in the other nine, film size was smaller. Plain radiography of the lumbar spine including both hip joints, may be a useful way to simultaneously evaluate lesions not only of the lumbar spine but also of the hip and/or pelvis.

Lim, Hyun Soo; Juhng, Seon Kwan; Kim, Eun A; Kim, Jeong Ho; Song, Ha Heon; Shim, Dae Moo [Wonkwang University School of Medicine, Iksan (Korea, Republic of)

2002-12-01

293

Rheumatoid factor measured by fluoroimmunoassay: a responsive measure of rheumatoid arthritis disease activity that is associated with joint damage  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objectives: To determine whether rheumatoid factors (RFs), measured as continuous variables by time resolved fluoroimmunoassay, reflect disease activity in rheumatoid arthritis (RA). Further, to study the association of RFs and other disease activity parameters with radiological joint damage, especially in individual patients.

Knijff-dutmer, E.; Drossaers-bakker, W.; Verhoeven, A.; Sluijs, Ve G.; Boers, M.; Linden, S.; Laar, M.

2002-01-01

294

Assessment of mutilans-like hand deformities in chronic inflammatory joint diseases. A radiographic study of 52 patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVES—To evaluate patients with mutilans-like hand deformities in chronic inflammatory joint diseases and to determine radiographic scoring systems for arthritis mutilans (AM).?METHODS—A total of 52 patients with severe hand deformities were collected during 1997. A Larsen hand score of 0-110 was formed to describe destruction of the hand joints. Secondly, each ray of the hand was assessed individually by summing the Larsen grade of the wrist and the grades of the MCP and PIP...

1999-01-01

295

MTADM: The new Joint Master Programme in Transboundary Animal Disease Management for Eastern Africa  

International Nuclear Information System (INIS)

Full text: New Partnership for Africa's Development (NEPAD) flagship Comprehensive Africa Agriculture Development Programme (CAADP). Focus is on livestock for trade and export. Better policies, institutions, regulatory framework and technologies are sought for livestock production and management and delivery of veterinary services and disease control. The disease status of African countries places the pivotal constraints on trade possibilities. Animal health standards imposed by importing countries for international, regional or bi-lateral trade, and through the World Trade Organisation's (WTO) Sanitary and Phytosanitary (SPS) agreement must be met. 12 of the 15 most important transboundary animal diseases persist in Africa. Disease control under SPS, entailing new standards, regulations and technologies, can and is not be covered by conventional veterinary training. This specialist area of its own has to be addressed in a specialised postgraduate course for young personnel already involved and responsible for public, private and hybrid animal disease control services. Ambitious visions of a new African livestock sector with changed focus on production, disease, trade, marketing, organisation, delivery and internationality are only realistic with newly trained animal disease control personnel. To target these issues at the academic level the Addis Ababa University / Ethiopia with universities of 3 regional partner countries (Kenya, Uganda, Sudan) and the Freie Universitaet Berlin, Germany, successfully applied for a grant to establish a Joint Master Course in Transboundary Animal Disease Management (MTADM) for Africa. The 3-year project is funded under the EU - EDULINK Programme of the 9th European Development Funds (EDF) as from 2008 to 2010. Currently, preparatory work is ongoing on the final technical details of the MTADM Course. The overall objective of the programme is to strengthen the capacity of national veterinary services in Africa to control and manage trans-boundary and epidemic diseases more effectively in a regional concerted action so as to (a) contributing towards developing or expanding exports markets and trade for animals and animal products and, (b) improve in the longer run the livelihood of livestock keepers as well as consumers demands on quality and safety of animal products. The specific objectives are to build human resource capacity by producing an effective cadre of professionals in regional / trans-boundary animal disease control and management and to strengthen the regional network of the veterinary faculties of the participating African countries. This is to be achieved through: - the development of an innovative and state-of-the-art curriculum for the Joint MTAD Programme, - a first MTADM course executed at Addis Ababa University/Ethiopia, Freie Universitaet Berlin, and the African home country of the participant, - a second MTADM Course prepared and ready to be launched at a second Regional Partner University, and - a first group of at least 15 graduates being highly qualified and ready to take up meaningful employment in the animal disease control sectors. The MTADM Master Course is delivered as cross-border 'sandwich' programme, in modular form (EU system of ECTS credits; 120 ECTS total) with the Master Thesis carried out as a field study project under guidance of the partner universities in the African region. The MTADM Master Programme is directed towards young early-career professionals already involved in animal disease and sanitary control activities but who identified academic master-level training needs for innovative tools and methods in transboundary animal disease management to advance their career. The Course Announcement will be circulated early 2009 and applications are welcome before October 2009; qualified candidates may apply for scholarships provided by German, regional and international organisations. (author)

2009-06-08

296

Three-dimensional helical CT imaging of bone and joint diseases in the trunk and the hip joints. Pt. 1  

Energy Technology Data Exchange (ETDEWEB)

To confirm the utility of CT scan images for orthopedic surgeons managing patients with complex disorders, we have produced and studied three-dimensional images from helical CT scans of 28 patients with various bone and joint disorders in the trunk and the hip joint. The CT scanner employed was a Toshiba X-force, and the 3D-CT images were constructed on an X-link50. The 3D images obtained could be observed from various projections. Congenital vertebral malformations, spondylosis, OPLL, osteonecrosis, fractures, and bone tumors were examined, and the 3D helical CT images brought useful information to bear on the spatial location and extent of the lesions. Therefore, 3D helical CT should become an indispensable tool for both preoperative examination and post-operative follow-up studies in orthopedic surgery. (author)

Gong Hohghan [Jangxi Medical Coll. (China). First Affiliated Hospital; Hiraishi, Kumiko; Doi, Miwako; Matsui, Ritsuo; Simizu, Tadafumi; Sueyoshi, Kouzou; Narabayashi, Isamu

1997-12-01

297

Interleukin-23 and its correlation with disease activity, joint damage, and functional disability in rheumatoid arthritis.  

Science.gov (United States)

The purpose of this study was to compare the serum interleukin (IL)-23 levels between rheumatoid arthritis (RA) patients and healthy controls and to determine the correlation of IL-23 levels with disease activity, joint damage and functional disability in RA. Serum samples were obtained from 45 patients with RA and 45 healthy controls. The enzyme-linked immunosorbent assay method was used for quantitative analysis of IL-23. All the RA patients were assessed for disease activity based on the 28-joint disease activity score, joint damage based on modified Sharp score, and functional ability using the Health Assessment Questionnaire-Disability Index. The mean serum IL-23 level was much higher among the RA patients (24.50 ± 13.98 pg/mL) compared to the controls (5.98 ± 3.40 pg/mL; p disease activity and questionnaire scores (p = 0.003 and 0.020, respectively). On logistic regression analysis, IL-23 levels were significantly higher in patients with moderate to high disease activity (p = 0.008, odds ratio = 1.073, 95% confidence interval = 1.019-1.130) and patients with significant functional disability (p = 0.008, odds ratio = 1.085, 95% confidence interval = 1.021-1.153). RA patients have significantly higher levels of serum IL-23. The IL-23 levels correlate well with disease activity and functional disability but not with radiographic joint damage. PMID:24924839

Dalila, Adnan Siti; Mohd Said, Mohd Shahrir; Shaharir, Syahrul Sazliyana; Asrul, Abdul Wahab; Low, Soo Fin; Shamsul, Azhar Shah; Sakthiswary, Rajalingham

2014-07-01

298

Osteoarthritis of the scaphoidtrapezium joint: an early sign of calcium pyrophosphate dihydrate disease.  

Science.gov (United States)

The aim of this study was to determine the value of scaphoidtrapezium osteoarthritis (ST osteoarthritis) as an early sign of calcium pyrophosphate dihydrate disease (CPDD) in a cohort of patients undergoing surgery for osteoarthritis of the first carpometacarpal joint. We examined whether patients with cartilage calcification of the wrist at the time of operation had ST osteoarthritis, indicating CPDD at an earlier time (retrospective study), and whether patients with ST osteoarthritis but without cartilage calcification at the time of surgery develop radiological or clinical signs of CPDD at a later time (prospective study). From 1 January 1989 to 31 December 1995 a total of 169 patients (from an orthopaedic clinic) with a diagnosis of osteoarthritis of the first carpometacarpal joint were included in the study; 167 underwent surgery and two were treated without. Of the 16 patients showing calcification on surgery and therefore included in the retrospective study, 12 had prior radiographs, of which eight showed ST osteoarthritis. Among these, four had no concomitant cartilage calcification in the prior radiographs. Of the 32 patients in the prospective group having ST osteoarthritis but no calcifications at the time of surgery, 27 could be clinically examined. Of these, two showed cartilage calcifications on the follow-up radiographs of the hands. The presence of ST osteoarthritis is a helpful diagnostic finding for the diagnosis of CPDD, especially in cases without radiographic cartilage or fibrocartilage calcification of the wrist. ST osteoarthritis may then point to the correct diagnosis. PMID:11254235

Peter, A; Simmen, B R; Brühlmann, P; Michel, B A; Stucki, G

2001-01-01

299

Scintigraphy by Means of Radioisotopes of Short Half-Life for Diagnosing Diseases of the Joints  

International Nuclear Information System (INIS)

Persons suffering from articular diseases exhibit an increase in vascularization associated with a concomitant inflammatory process. This hyper-vascularization can be visualized in cases of rheumatoid arthritis by means of radiotracer scanning of the vascular compartment, as indicated by Maxfield in 1965. The authors present the results of a study of 107 persons suffering from various articular conditions. The study was based on radioisotope scanning with 99mTc and 113mIn. For this purpose they made use of commercial apparatus with a .5-in. crystal and an 85-hole focussed collimator. They applied 6-10 mCi of 99mTc in the form of sodium pertechnetate and 8-10 mCi as indium chloride (adjusted to pH 3.5), both administered intravenously at 24-hour intervals. Different scintigraphic images were observed for each of the radioisotopes, the degree of concentration not being identical for a given joint. The procedure was useful for the early diagnosis of articular lesions and in some cases for carrying out differential diagnosis. It is also indicated that the increase in vascular permeability would afford the most satisfactory explanation for the increaised radioactivity in the joints when 99mTc is used as pertechnetate, even though other factors might exist apart from the increase in vascularization, which was not satisfactorily shown when 113mIn was used. (author)

1969-05-01

300

Severe destructive arthritis of the carpometacarpal joint: a diagnosis of exclusion case report.  

Science.gov (United States)

We present a case of severe destruction of the thumb carpometacarpal joint (CMCJ) and surrounding structures on a background of osteoarthritis and Seronegative Rheumatoid arthritis. Imaging studies suggested a soft tissue lesion consistent with Pigmented Villonodular Synovitis (PVNS), Synovial Osteochondromatosis or Giant Cell Tumour (GCT). Due to the possibility of malignant transformation and deteriorating symptoms the mass was excised. Histological analysis of the lesion revealed severe degenerative disease with no evidence of malignancy or infection. This represents an atypical presentation of thumb carpometacarpal joint arthritis, which should be diagnosed once more sinister pathology has been excluded. PMID:24662912

Vaghela, Kalpesh R; Patel, Nirav K; Sarraf, Khaled M; Owers, Kate

2013-01-01

 
 
 
 
301

[The Dead Sea--a unique resort for patients suffering from joint diseases].  

Science.gov (United States)

The Dead Sea area is an excellent and unique resort for patients suffering from a wide range of inflammatory and non-inflammatory joint diseases. Factors contributing to the beneficial effect are the high concentration of salts and minerals in the Dead Sea water and in the water from springs in the area, medical mud, and the unique climatic conditions including high barometric pressure, relative low humidity and high temperatures. This review describes the various balneotherapy modalities and the existing body of research describing their utility. Balneotherapy significantly improves most patients' conditions and in some cases leads to complete remission of several months duration. Although of importance, balneotherapy is not curative. An important advantage of balneotherapy is the lack of serious adverse effects, and, in contrast to some physicians' beliefs, the scarcity of contraindications for therapy at the Dead Sea area. PMID:20684171

Sukenik, Shaul; Flusser, Daniel; Codish, Shlomi; Abu-Shakra, Mahmoud

2010-03-01

302

Prevalence of Joint Hypermobility and Patterns of Articular Manifestations in Patients with Inflammatory Bowel Disease  

Directory of Open Access Journals (Sweden)

Full Text Available Objective. The objective is the investigation of Joint Hypermobility (JH and the Hypermobility Syndrome (HMS in patients with inflammatory bowel disease (IBD. Methods. We examined 83 patients with IBD and 67 healthy individuals for the presence of JH. Patients were excluded if they were under 18 or over 50 years of age and if they had other conditions which affect joint mobility. The x2 and the Fisher exact test were used appropriately between study groups. Odds ratios (ORs for the risk of JH and HMS in IBD groups were calculated. Results. A total of 150 individuals (83 IBD patients and 67 healthy controls participated in the study. 69 IBD patients, 41 with Crohn's Disease (CD and 28 with ulcerative colitis (UC, were finally eligible. JH was detected in 29 CD patients (70.7%, in 10 UC patients (35.7%, and in 17 healthy control subjects (25.4%. Significant difference was detected on JH in CD patients as compared to UC patients (P=.0063 and controls (P<.0001. The estimated OR for JH was 7.108 (95% CI: 2.98–16.95 in CD and 1.634 (95% CI: 0.63–4.22 in UC patients. HMS was detected in 5 (12.2% CD and in 1 (3.57% UC patients. The OR for HMS in CD was 3.75 (95% CI: 0.41–34.007, while 7 (17.1% CD patients had overlapping symptoms for both HMS and early spondylarthropathy. Conclusions. JH and the HMS are common in CD patients, thus articular manifestations should be carefully interpreted. This implies an involvement of collagen varieties in the pathogenesis of IBD.

P. Vounotrypidis

2009-01-01

303

Krabbe Disease  

Science.gov (United States)

NINDS Krabbe Disease Information Page Synonym(s): Globoid Cell Leukodystrophy Table of Contents (click to jump to sections) What is ... Trials Organizations Additional resources from MedlinePlus What is Krabbe Disease? Krabbe disease is a rare, inherited degenerative ...

304

Quantitative scintigraphy of the sacroiliac joints and spinal column in Bechterev's disease (spondylitis ankylopoetica)  

Energy Technology Data Exchange (ETDEWEB)

Quantitative scintigraphy of the sacroiliac joints and the spinal column was performed in 138 patients with verified Bechterev's disease and in a control group of 104 healthy subjects, who had no clinical, roentgenographic and laboratory evidence of illness of the sacroiliac joints and the spinal column. By comparing skeletal ''zones of interest'' the author studied the following quantitative parameters: sacroiliac index (separately for the right and left sacpoiliac joint); C/sub 7//sacrum index; D/sub 10//sacrum and L/sub 4//sacrum indices. The main values of these indices in the control group were accordingly 114.5 and 113.7 (for the right and left sacroiliac joints); 59; 95; 90. In patients with Bechterev's disease these indices were raised: 154 and 149 (for right and left sacroiliac joints); 75; 123; 113. Peak diagnostic value have the sacroiliac indices and the D/sub 10//sacrum, index, which appeared to be elevated in more than 95 per cent of the tested patients with verified Bechterev's disease.

Mlychkov, Kh. (Meditsinska Akademiya, Sofia (Bulgaria). Nauchen Inst. po Rentgenologiya i Radiobiologiya)

1982-01-01

305

Comparative diagnostic imaging of the canine shoulder joint: ultrasonography and radiography  

International Nuclear Information System (INIS)

Ultrasonography of shoulder joint disease has been applied in humans for some time. In this study, the use of radiography and ultrasonography as diagnostic imaging modalities to determine shoulder joint lesions is presented. The ultrasonographic anatomy and pathology of the shoulder joint are described. Comparative radiographic and ultrasonographic findings in 67 dogs with front limb lameness and/or radiographically visible shoulder joint lesions are presented. Shoulder joint lesions include insertion tendinopathies of the supra- and infraspinatus muscles, distension of the subtendinous bursa of the infraspinatus muscle, bicipital tendinopathies, such as tendovaginitis, calcifications, partial and complete rupture, and avulsion fractures at the supraglenoid tubercle, osteochondritis dissecans, degenerative joint disease, bony proliferations in the intertuberal groove, and neoplasia of bones and soft-tissues. Ultrasonographic diagnosis of tendon abnormalities and other soft tissue lesions is a necessary supplemental examination to radiographs, which should always be the basis for orthopedic diagnostic imaging. When using both imaging techniques, the exact location of radio-opaque mineralizations can be determined and a more accurate diagnosis made. The ultrasonographic appearance of an infraspinatus muscle insertion tendinopathy in conjunction with distension of the subtendinous bursa is reported for the first time. Low-density calcifications are not visible radiographically. 6 of 17 supraspinatus insertion tendinopathies (35.3 %) and 4 of 5 bicipital tendon calcifications (80 %) were detected only with ultrasonography. Radiographic findings of bony proliferations in the intertuberal groove without signs of degenerative joint disease of the shoulder joint are indicative of severe or chronic biciptal tendon disease. In many cases, the stage and severity of cartilaginous and subchondral bone lesions with osteochondritis dissecans can be determined ultrasonographically. Osteochondritis dissecans defects not seen on radiographs are occasionally visible with ultrasound, although a negative finding is not always accurate. (author)

2000-01-01

306

Defining the research agenda to reduce the joint burden of disease from diabetes mellitus and tuberculosis  

DEFF Research Database (Denmark)

The steadily growing epidemic of diabetes mellitus poses a threat for global tuberculosis (TB) control. Previous studies have identified an important association between diabetes mellitus and TB. However, these studies have limitations: very few were carried out in low-income countries, with none in Africa, raising uncertainty about the strength of the diabetes mellitus-TB association in these settings, and many critical questions remain unanswered. An expert meeting was held in November 2009 to discuss where there was sufficient evidence to make firm recommendations about joint management of both diseases, to address research gaps and to develop a research agenda. Ten key research questions were identified, of which 4 were selected as high priority: (i) whether, when and how to screen for TB in patients with diabetes mellitus and vice versa; (ii) the impact of diabetes mellitus and non-diabetes mellitus hyperglycaemia on TB treatment outcomes and deaths, and the development of strategies to improve outcomes;(iii) implementation and evaluation of the tuberculosis 'DOTS' model for diabetes mellitus management; and (iv) the development and evaluation of better point-of-care diagnostic and monitoring tests, including measurements of blood glucose and glycated haemoglobin A(1c) (HbA(1c)) for patients with diabetes mellitus. Implementation of this research agenda will benefit the control of both diseases.

Harries, Anthony D; Murray, Megan B

2010-01-01

307

A digital-signal-processor-based optical tomographic system for dynamic imaging of joint diseases  

Science.gov (United States)

Over the last decade, optical tomography (OT) has emerged as viable biomedical imaging modality. Various imaging systems have been developed that are employed in preclinical as well as clinical studies, mostly targeting breast imaging, brain imaging, and cancer related studies. Of particular interest are so-called dynamic imaging studies where one attempts to image changes in optical properties and/or physiological parameters as they occur during a system perturbation. To successfully perform dynamic imaging studies, great effort is put towards system development that offers increasingly enhanced signal-to-noise performance at ever shorter data acquisition times, thus capturing high fidelity tomographic data within narrower time periods. Towards this goal, I have developed in this thesis a dynamic optical tomography system that is, unlike currently available analog instrumentation, based on digital data acquisition and filtering techniques. At the core of this instrument is a digital signal processor (DSP) that collects, collates, and processes the digitized data set. Complementary protocols between the DSP and a complex programmable logic device synchronizes the sampling process and organizes data flow. Instrument control is implemented through a comprehensive graphical user interface which integrates automated calibration, data acquisition, and signal post-processing. Real-time data is generated at frame rates as high as 140 Hz. An extensive dynamic range (˜190 dB) accommodates a wide scope of measurement geometries and tissue types. Performance analysis demonstrates very low system noise (˜1 pW rms noise equivalent power), excellent signal precision (˜0.04%--0.2%) and long term system stability (˜1% over 40 min). Experiments on tissue phantoms validate spatial and temporal accuracy of the system. As a potential new application of dynamic optical imaging I present the first application of this method to use vascular hemodynamics as a means of characterizing joint diseases, especially effects of rheumatoid arthritis (RA) in the proximal interphalangeal finger joints. Using a dual-wavelength tomographic imaging system and previously implemented reconstruction scheme, I have performed initial dynamic imaging case studies on healthy volunteers and patients diagnosed with RA. These studies support our hypothesis that differences in the vascular and metabolic reactivity exist between affected and unaffected joints and can be used for diagnostic purposes.

Lasker, Joseph M.

308

Transarticular invasion of bone tumours across the sacroiliac joint  

International Nuclear Information System (INIS)

The purpose of this study was to evaluate the pattern of tumour spread across the SI articulation, correlating with cadaveric anatomic observations, in order to better understand the local spread of tumour and to assist in the assessment of local staging. Twenty-four consecutive patients (14 male, 10 female; age range 22-89 years, mean 52 years) with primary bone tumours of the iliac bone or sacrum abutting the SI joint, in whom surgical resection of the SI joint was performed, were studied following institutional ethics approval. In all patients, preoperative magnetic resonance (MR) imaging studies of the pelvis and SI joint were reviewed for imaging evidence of transarticular extension across the SI joint. Gross pathologic and histologic assessment of possible transarticular SI joint tumour extension was performed in all patients. Nine cadaveric pelvic specimens without pelvic neoplastic disease (4 male, 5 female; age range 20-84 years, mean 59 years, median 58 years) were anatomically dissected and the articular anatomy of the SI joint examined macroscopically. Twelve of the twenty-four patients demonstrated imaging and histological evidence of transarticular SI joint invasion. Eight tumours infiltrated only the interosseous ligamentous aspect of the SI joint. In the remaining four cases, extensive tumour infiltrated both the cartilaginous and ligamentous aspects of the joint. No case showed tumour involvement isolated to the cartilaginous aspect of the joint. Among the cadaveric specimens studied, degenerative changes were found involving the majority of cases (6/9), with cartilage thinning and fibrillation and antero-superior marginal osteophytes seen involving the cartilaginous portion of the SI joint articulation. Four of the nine specimens demonstrated central ossification bridging the iliac and sacral aspects of the ligamentous (interosseous) SI joint. (orig.)

2005-12-01

309

Analgesic effects of intra-articular botulinum toxin Type B in a murine model of chronic degenerative knee arthritis pain  

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Full Text Available Stephanie Anderson1,2, Hollis Krug1,2, Christopher Dorman1, Pari McGarraugh1, Sandra Frizelle1, Maren Mahowald1,21Rheumatology Section, Veteran’s Affairs Medical Center, Minneapolis, Minnesota; 2Division of Rheumatology and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, Minnesota, USAObjective: To evaluate the analgesic effectiveness of intra-articular botulinum toxin Type B (BoNT/B in a murine model of chronic degenerative arthritis pain.Methods and materials: Chronic arthritis was produced in adult C57Bl6 mice by intra-articular injection of Type IV collagenase into the left knee. Following induction of arthritis, the treatment group received intra-articular BoNT/B. Arthritic control groups were treated with intra-articular normal saline or sham injections. Pain behavior testing was performed prior to arthritis, after induction of arthritis, and following treatments. Pain behavior measures included analysis of gait impairment (spontaneous pain behavior and joint tenderness evaluation (evoked pain response. Strength was measured as ability to grasp and cling.Results: Visual gait analysis showed significant impairment of gait in arthritic mice that improved 43% after intra-articular BoNT/B, demonstrating a substantial articular analgesic effect. Joint tenderness, measured with evoked pain response scores, increased with arthritis induction and decreased 49.5% after intra-articular BoNT/B treatment. No improvement in visual gait scores or decrease in evoked pain response scores were found in the control groups receiving intra-articular normal saline or sham injections. Intra-articular BoNT/B was safe, and no systemic effects or limb weakness was noted.Conclusions: This study is the first report of intra-articular BoNT/B for analgesia in a murine model of arthritis pain. The results of this study validate prior work using intra-articular neurotoxins in murine models. Our findings show chronic degenerative arthritis pain can be quantitated in a murine model by measuring gait impairment using visual gait analysis scores (spontaneous pain behavior and joint tenderness scores (evoked pain responses. Reduction of joint pain seen in this study is consistent with our hypothesis of inhibition of release of pain mediators by intra-articular BoNT/B, supporting further investigation of this novel approach to treatment of arthritis pain with intra-articular neurotoxins.Keywords: intra-articular BoNT/B, osteoarthritis

Stephanie Anderson

2010-09-01

310

The role of lumbar lordosis, vertebral end-plate inclination, disc height, and facet orientation in degenerative spondylolisthesis  

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Degenerative spondylolisthesis (DS) is a common condition of the aging spine, but the underlying pathomechanisms remain controversial. Most previous studies focused on the role of facet-joint alignment and reported a pronounced sagittal orientation. This, however, may also be a secondary feature to the slippage. This study analyzed several radiologic findings in the lower lumbar spine in 23 patients with DS (group A) and 40 age- and sex-matched controls (group B). Facet-joint angulation, inte...

Berlemann U; Jeszenszky D.J; Bühler D. W; Harms J; Jeszenszky Dezs? (1954-) (Ph.D hallgató)

1999-01-01

311

Reliability of the Jones Patellofemoral Osteoarthritis Score for Radiological Assessment of Patellofemoral Degenerative Changes: Comparing a Physiotherapist to Doctors  

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Purpose: Radiological measurement scores are used by orthopaedic physiotherapists in triage and surveillance of patients with degenerative changes of the tibiofemoral and patellofemoral joints. The purpose of this study was to estimate the intra- and inter-observer reliability of a radiological measurement score to assess patellofemoral joint osteoarthritis, the Jones Patellofemoral Osteoarthritis Score (JPOS), with an orthopaedic physiotherapist and three grades of junior surgeons/doctors. M...

Smith, T. O.; Kang, S. -n; Sprenger Rover, W. B.; Walton, N. P.

2012-01-01

312

Development of Modulators Against Degenerative Aging Using Radiation Fusion Technology  

International Nuclear Information System (INIS)

In this study, we selected final 20 biomarkers for the degenerative aging to develop radiation aging modeling, and validated a few of selected markers to utilize them in the screening of aging modulators. To select the biomarkers of the degenerative aging, 4 categories of aging-related markers (immune/hematopoiesis, oxidative damage, signaling molecule, lipid metabolism) were comparatively analyzed in irradiated and normally aged biosystems (cell lines or mice). In result, most of the biomarkers showed similar changes by irradiation and normal aging. Regarding the immune/hematopoiesis, the decline of immune cell functions (lymphocyte, NK cell) and Th1/Th2 imbalance, and decreased antigen-presenting of dendritic cells were observed and 10 biomarkers were selected in this category. mtDNA deletion was selected for the oxidative damage marker, 6 biomarkers including p21 and p-FOXO3a for signaling molecule biomarkers, and 3 biomarkers including the adipose tissue weight were selected for lipid metabolism. In addition, the various radiation application conditions by single/factionated irradiation and the periods after the irradiation were investigated for the optimal induction of changes of biomarker, which revealed that total 5Gy of 10 or more fractionated irradiations and 4 months or greather period were observed to be optimal. To found the basis for the screening of natural aging modulators, some selected aging biomarkers were validated by their inhibition by well-known natural agents (EGCG, HemoHIM, etc) in aged cell or mouse model. Additionally, by evaluating the reductive efficacy of 5 natural agents on the degeneration of skin and reproductive organs induced by radiation and chemicals (cyclophosphamide, etc), we established the base for the screening of degenerative diseases by various factors

2010-01-01

313

Development of Modulators Against Degenerative Aging Using Radiation Fusion Technology  

Energy Technology Data Exchange (ETDEWEB)

In this study, we selected final 20 biomarkers for the degenerative aging to develop radiation aging modeling, and validated a few of selected markers to utilize them in the screening of aging modulators. To select the biomarkers of the degenerative aging, 4 categories of aging-related markers (immune/hematopoiesis, oxidative damage, signaling molecule, lipid metabolism) were comparatively analyzed in irradiated and normally aged biosystems (cell lines or mice). In result, most of the biomarkers showed similar changes by irradiation and normal aging. Regarding the immune/hematopoiesis, the decline of immune cell functions (lymphocyte, NK cell) and Th1/Th2 imbalance, and decreased antigen-presenting of dendritic cells were observed and 10 biomarkers were selected in this category. mtDNA deletion was selected for the oxidative damage marker, 6 biomarkers including p21 and p-FOXO3a for signaling molecule biomarkers, and 3 biomarkers including the adipose tissue weight were selected for lipid metabolism. In addition, the various radiation application conditions by single/factionated irradiation and the periods after the irradiation were investigated for the optimal induction of changes of biomarker, which revealed that total 5Gy of 10 or more fractionated irradiations and 4 months or greather period were observed to be optimal. To found the basis for the screening of natural aging modulators, some selected aging biomarkers were validated by their inhibition by well-known natural agents (EGCG, HemoHIM, etc) in aged cell or mouse model. Additionally, by evaluating the reductive efficacy of 5 natural agents on the degeneration of skin and reproductive organs induced by radiation and chemicals (cyclophosphamide, etc), we established the base for the screening of degenerative diseases by various factors

Jo, Sung Kee; Jung, U.; Park, H. R.

2010-04-15

314

Hinged distraction of the hip joint in the treatment of Perthes disease: evaluation at skeletal maturity.  

Science.gov (United States)

The aim of this work is to determine the effect of this type of treatment on the shape of the femoral head, the range of motion (ROM), radiological changes in the femoral head, and the prognosis of Perthes disease at skeletal maturity. From 1998 to 2007, 53 patients with Perthes disease were treated with a combination of soft tissue release and joint distraction with a hinged monolateral external fixator in 32 patients and by Ilizarov external fixator in 21 patients. Nineteen of our 53 patients attained skeletal maturity and were evaluated in our study. This study included 15 boys and four girls, mean age at surgery 9.3 years (range 7.2-13.1), and mean age at the last follow-up 17.4 years (range 14.9-21.3). The duration of symptoms varied from a period of 6 to 60 months before the operation. Radiographs taken during the fragmentation stage of the disease were classified by the lateral pillar classification of Herring; 19 of our patients attained skeletal maturity and were evaluated. Clinical assessment included the Harris hip score, hip ROM, and limb length discrepancy. Radiographic assessment included sharp transverse acetabular inclination, the uncoverage percentage, the epiphyseal index before surgery (modified Eyre-Brook), at frame removal, and at the last follow-up, the epiphyseal quotient (of Sjovall), and the Stulberg classification. The mean follow-up was 7.2 years (range 4.1-11.3). The mean Harris hip score was 87.1/100 (range 49.2-94.8). An improvement in hip (ROM) of 83.3% of the normal range was restored. There was a marked improvement in the degree of pain and limp postoperatively. The hip ROM was slightly limited in most patients, and seven patients had limb shortening of between 1 and 3 cm. The mean sharp transverse acetabular inclination of the affected side was 44° (range 35-51) compared with 37° for the unaffected side (P=0.042). The mean uncoverage percentage was 36% (range 24-45) compared with 21% for the unaffected side (P=0.027). The mean epiphyseal index was 0.74 (range 0.36-0.94) before surgery, 0.78 (range 0.49-0.89) at frame removal (P=0.017), and 0.80 (range 0.54-0.91) at the last follow-up (P=0.701). The epiphyseal quotient was 0.74 (range 0.51-0.94) and the Stulberg classifications were type II in eight patients, type III in seven patients, type IV in three patients, and type V in one patient. Arthrodiastasis of the hip joint with soft tissue release may represent a good contribution toward the treatment of Legg-Calvé-Perthes disease. This method of treatment has many advantages such as easy technique, minimal rate of complications, a short hospitalization period, correction of shortening because it adds to the length of the limb, and a higher rate of acceptable results than would be expected compared with other methods. It also improves the ROM, reduces superior and lateral subluxation, and provides better radiographic sphericity of the femoral head. In addition, it does not distort the anatomy of the pelvis or the proximal femur; it can be used with equal success in older children who are typically expected to have a poor prognosis. Distraction treatment is not limited by hip stiffness, degree of femoral head deformity, or subluxation, and can be used when other methods of treatment are contraindicated. PMID:22713742

Laklouk, Mohamed Abdel-Rehim; Hosny, Gamal Ahmed

2012-09-01

315

[Epidemiology of bone and joint disease - the present and future - . Epidemiology of falls].  

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A longitudinal analysis using a population-based cohort study known as Research on Osteoarthritis/osteoporosis Against Disability (ROAD) clarified the associations of physical performance and bone and joint diseases with falls. A total of 452 men and 896 women were analyzed in the present study (mean age, 63.9 years). A questionnaire was used to assess the number of falls during the 3-year follow-up. Grip strength, 6-m walking time, and chair stand time were measured at baseline. Knee osteoarthritis (OA) and lumbar spondylosis were defined as Kellgren Lawrence = 3 or 4. Vertebral fracture (VFx) was assessed with the Japanese Society of Bone and Mineral Research criteria. Knee and lower back pain were estimated by an interview. During a 3-year follow-up, 17.4% men and 24.1% women reported at least one fall. Multinomial logistic regression analysis after adjustment for age and BMI showed that a longer 6-m walking time was a risk factor for multiple falls in men and women. Knee pan was also a risk factor for multiple falls in women. Walking time and knee pain may be a simple and quick option for measuring the risk of falling. PMID:24769678

Muraki, Shigeyuki

2014-05-01

316

Toward a joint health and disease management program. Toronto hospitals partner to provide system leadership.  

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The Joint Health and Disease Management Program in the Toronto Central Local Health Integration Network (TC LHIN) is envisioned as a comprehensive model of care for patients with hip and knee arthritis. It includes access to assessment services, education, self-management programs and other treatment programs, including specialist care as needed. As the first phase of this program, the hospitals in TC LHIN implemented a Hip and Knee Replacement Program to focus on improving access and quality of care, coordinating services and measuring wait times for patients waiting for hip or knee replacement surgery. The program involves healthcare providers, consumers and constituent hospitals within TC LHIN. The approach used for this program involved a definition of governance structure, broad stakeholder engagement to design program elements and plans for implementation and communication to ensure sustainability. The program and approach were designed to provide a model that is transferrable in its elements or its entirety to other patient populations and programs. Success has been achieved in creating a single wait list, developing technology to support referral management and wait time reporting, contributing to significant reductions in waits for timely assessment and treatment, building human resource capacity and improving patient and referring physician satisfaction with coordination of care. PMID:19369812

Macleod, Anne Marie; Gollish, Jeffrey; Kennedy, Deborah; McGlasson, Rhona; Waddell, James

2009-01-01

317

Infection of the sigmoid colon during TNF? antagonist therapy for chronic inflammatory joint disease.  

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We report 7 cases of sigmoid colon infection in patients taking TNF? antagonist therapy to treat chronic inflammatory joint disease. There were 5 women and 2 men with a mean age of 57.5years (range, 21-77years). The presenting symptoms were abdominal pain, bowel habit changes, and a fever. These symptoms developed within 6months after starting TNF? antagonist therapy in 5 of the 7 patients. Empirical antibiotic therapy was used in all 7 patients. Surgical colectomy was performed in 4 patients, including 1 who required a temporary Hartmann's procedure. The risk of infection associated with TNF? antagonist therapy is well documented. However, few cases of colon infection have been reported and little is known about this potentially severe complication. Glucocorticoids or non-steroidal anti-inflammatory drugs may worsen the infection, particularly as they can attenuate the clinical symptoms, thereby delaying the diagnosis. A history of sigmoid colon infection, diverticulosis, and/or diverticulitis must be sought before starting treatment with a biological agent. Prophylactic treatment may be considered if such a history is found. Diagnostic investigations are in order to develop a standardized management strategy in patients with a history of intestinal tract infection. PMID:24176737

Moyano, Chantal; Beldjerd, Mounir; Pécourneau, Virginie; Billey, Thierry; Lassoued, Slim

2014-05-01

318

Mycotoxicological investigations on maize and groundnuts from the endemic area of Mseleni joint disease in Kwazulu.  

Science.gov (United States)

Samples of home-grown maize and groundnuts from the endemic area of Mseleni joint disease (MJD) during four seasons (1980-1983) were examined mycologically. The mycoflora of these dietary staples included Fusarium poae and F. oxysporum, which have been implicated in the aetiology of Kashin-Beck or Urov disease, another osteo-arthrosis endemic in Siberia and China. Two other species of Fusarium, i.e. F. moniliforme and F. equiseti, implicated in syndromes of abnormal bone development in animals, were also present. The predominant fungus associated with maize kernels was F. moniliforme; two other fungi relatively frequently isolated from Mseleni maize, i.e. F. compactum and Lasiodiplodia theobromae, have not previously been reported in maize in southern Africa. The predominant fungi associated with groundnut kernels were Penicillium spp., L. theobromae, Macrophomina phaseolina and F. oxysporum. The incidence of certain fungi, particularly F. compactum, F. oxysporum and L. theobromae, appeared to be higher in dietary staples from households affected by MJD than from non-affected ones. The numbers of samples examined were, however, small and these findings need to be confirmed. Cultures of 120/322 isolates of fungi from Mseleni dietary staples proved toxic to ducklings, the most toxic species being F. compactum, F. moniliforme, F. oxysporum and Phomopsis sp. The characteristic pathological changes of MJD have, however, not been induced in experimental animals with cultures of any of these fungi. A diet containing maize and groundnuts from households affected by MJD also failed to induce the characteristic osteo-arthritic changes of MJD in rats. The dietary staples used in this experiment were, however, collected during seasons of abnormally low rainfall at Mseleni.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3961620

Marasas, W F; Van Rensburg, S J

1986-03-15

319

CD4 T cells in the rheumatoid joint are oligoclonally activated and change during the course of disease.  

Science.gov (United States)

OBJECTIVE--To assess the nature of T cell receptor (TCR) utilisation by CD4 T cells in the rheumatoid joint. METHODS--Sequencing of the joining (NDJ) region of TCR beta chain mRNA isolated from synovial fluid CD4 T cells was performed in three patients in order to determine if oligoclonal expansion of particular sequences was present. Two patients were studied longitudinally to determine if these sequences changed over time. RESULTS--A number of dominant clonotypes were found within the TCR transcripts sequenced in each patient. In the two patients who were studied longitudinally, different dominant clonotypes were detected over time. No single clonotype was persistently dominant during the period of study. CONCLUSIONS--The pattern of TCR usage showed multiple oligoclonally expanded CD4 T cells within the rheumatoid joint. The change in clonotypes within the joint over time suggests that different antigens may be able to elicit synovial inflammation during the course of rheumatoid disease.

Khazaei, H A; Lunardi, C; So, A K

1995-01-01

320

Instrumentação interespinhosa na doença degenerativa da coluna lombar: medição da altura do disco no segmento instrumentado Instrumentación interespinosa en la enfermedad degenerativa de la columna lumbar: medición de la altura del disco en el segmento instrumentado Interspinous instrumentation in patients with degenerative lumbar spine disease: disc height measurement on instrumented segment  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUÇÃO: na última década, a instrumentação interespinhosa vem sendo mais frequentemente utilizada. Apesar dos inúmeros artigos publicados em revistas internacionais de reconhecido mérito científico, são escassas as referências à modificação da altura do disco no segmento tratado, secundária àquela instrumentação. OBJECTIVO: quantificar uma eventual modificação da altura discal decorrente da aplicação de instrumentação interespinhosa (DIAM - Cousin-Biotech - Medtronic Sofamor Danek Inc©. MÉTODOS: o autor avalia um grupo de 20 pacientes com patologia degenerativa da coluna lombar e os seguintes critérios de inclusão: idade >40 e 6; Oswestry Disability Index (ODI >30; Zung Depression Rating Scale INTRODUCCIÓN: la instrumentación interespinosa tiene sido empleada con creciente frecuencia en la última década. Pero, apesar de las numerosas publicaciones científicas hechas en jornales científicos de reconocido mérito internacional, se han producido muy escasas referencias a una hipotética modificación de la altura discal dependiente de la técnica. OBJETIVO: cuantificar una eventual modificación de la altura discal inherente a la aplicación de instrumentación interespinosa. MÉTODOS: el autor hace una evaluación de un grupo de 20 pacientes con patología degenerativa de la columna lumbar, y diversos criterios de inclusión, a saber: edad >40 y 6; Oswestry Disability Index >30; Zung Depression Rating Scale INTRODUCTION: the use of interspinous instrumentation has been increasing in the last decade. However, in spite of the numerous papers seen in relevant scientific publications, there are very few references to an eventual disc height variation in the instrumented segment. OBJECTIVE: to certify eventual changes in disk height after interspinous instrumentation (DIAM - Cousin-Biotech - Medtronic Sofamor Danek Inc©. METHODS: the author evaluated 20 patients with degenerative lumbar disease and the following criteria: age >40 and 6; Oswestry Inability Index >30; Zung Depression Rating Scale <39; Modified Somatic Perception Questionnaire <15; degenerative bone disease grade 2 and 3 according to Benzel classification and degenerative disk disease grade 3 and 4 according to Pfirmann classification. Using a special formula and a computer image program (Adobe Photoshop 9.0 CS2, side radiograms of the lumbar spine in orthostatic position and with 70% amplification were obtained pre-surgery and two years after surgery. RESULTS: after applying the mentioned formula, the results showed an increased global disk height average 1.53 mm, with a standard deviation of 1.09 mm and p=0.0002. However, there was a large increase (0.45 mm in posterior disk height (p=0.0002 when compared with anterior measurement (p=0.001 pointing out a slight kyphosing effect related to the instrumentation. CONCLUSIONS: in Benzel grade 2 and 3 and Pfirmann grade 3 and 4 degenerative lumbar disease, the use of an interspinous system seemed to be able to increase disk height and to improve neural canal dimensions.

José Alberto de Castro Guimarães Consciência

2009-09-01

 
 
 
 
321

Enthesitis in seronegative spondyloarthropathies with special attention to the knee joint by MRI: a step forward toward understanding disease pathogenesis.  

Science.gov (United States)

Seronegative spondyloarthropathies are a unique group of disorders sharing similar clinical characteristics (e.g., inflammatory back pain, spondylitis, sacroiliitis, uveitis, inflammatory bowel disease, skin rashes, and enthesitis). Clinical and genetic similarities suggest that they also share similar causes or pathophysiologies. Rheumatoid factor (RF) is characteristically negative in this group of disorders, hence collectively termed seronegative spondyloarthropathies (SpA). They include psoriatic arthritis, ankylosing spondylitis, reactive arthritis, ulcerative colitis, and Crohn's disease. "Enthesitis", the term used to describe inflammation at tendon, ligament, or joint capsule insertions, is considered a common feature in this domain and was included in the European Spondyloarthropathy Study Group criteria for the classification of SpA. Evaluation of entheseal-related changes at different joints by MRI became an important item on the research agenda in both differentiated and undifferentiated arthritis. Most of the research focused on MRI findings in the hand and wrist joints among patients with RA and SpA and support two patterns of inflammation "RA" phenotype where synovial involvement is the primary target of inflammation and "SpA" pattern where enthesitis comes first followed by synovitis. In this review, we summarize the literature on enthesitis in SpA and focus on MRI findings in the knee joint in the SpA group of disorders and subclinical synovitis among patients with skin psoriasis. PMID:21210292

Yasser, Ragab; Yasser, Emad; Hanan, Darweesh; Nashwa, El Shaarawy; Rasker, Johannes J

2011-03-01

322

Estenosis espinal lumbar degenerativa / Degenerative spinal lumbar stenosis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Fundamento: el aumento progresivo de la esperanza de vida viene acompañado de una mayor incidencia de las enfermedades degenerativas del raquis como la estenosis espinal. Objetivo: actualizar y sistematizar los conocimientos sobre la estenosis espinal degenerativa del canal espinal lumbar. Método: s [...] e realizó una revisión de la literatura de los último cinco años. Se insistió en la clasificación, patogenia, diagnóstico y tratamiento. Desarrollo: la estenosis espinal degenerativa del canal lumbar es un desorden multifactorial caracterizado por un estrechamiento del canal vertebral, del receso lateral o de los agujeros de conjunción secundaria a hipertrofia degenerativa y progresiva de cualquiera de las estructuras óseas, cartilaginosas o ligamentosas que culmina en una compresión neurológica y vascular. La claudicación neurogéna es de los síntomas más característicos. El diagnóstico se basa en las mediciones realizadas en las imágenes de tomografía axial computarizada y en la resonancia nuclear magnética. Las opciones terapéuticas incluyen el tratamiento conservador y el quirúrgico, con las técnicas descompresivas convencionales y las de mínima invasión, preferidas en la actualidad. Conclusiones: la estenosis espinal degenerativa es una enfermedad multifactorial. El diagnóstico se fundamenta en la sospecha clínica confirmada en los estudios imagenológicos. Para la elección del tratamiento deben tenerse en cuenta factores relacionados con el paciente, con las características de la estenosis y con la disponibilidad de la tecnología. El objetivo de la cirugía se encaminará a descomprimir las estructuras neurovasculares y respetar la estabilidad del raquis para disminuir la morbilidad posoperatoria. Abstract in english Background: the progressive increase of life expectancy came along with a greater incidence of degenerative diseases of the rachis like spinal stenosis. Objective: to systematize and bring the knowledge about degenerative spinal stenosis of the spinal lumbar channel up to date. Method: a review of t [...] he literature from the last five years was made, making emphasis in the classification, pathogeny, diagnosis, and treatment. Development: degenerative spinal stenosis of the lumbar channel is a multifactorial disorder characterized by a narrowing of the vertebral channel, of the lateral recess, or of the secondary intervertebral foramina, conditions commonly observed in degenerative and progressive hypertrophy of any of the cartilaginous, ligamentous, or osseous structures that ends in a neurologic or vascular squeeze. Neurogenic claudication is one of the most characteristic symptoms. The diagnosis is based on measuring made through the images in the computerized axial tomography and in the nuclear magnetic resonance. The therapeutic options include the conservative treatment and the surgical treatment, with conventional decompressing techniques and the techniques of minimal invasion that are the most used nowadays. Conclusions: degenerative spinal stenosis is a multifactorial disease. The diagnosis is based on the clinical suspicion confirmed through imagenology studies. Some factors related to the patient, to the characteristics of the stenosis, and to the availability of the technology should be taken into consideration for choosing the treatment. The objective of the surgery will be aimed at decompressing the neurovascular structures and keeping the stability of the rachis in order to reduce the postoperative morbidity.

Erick Héctor, Hernández González; Antonio, Puente Álvarez; Gretel, Mosquera Betancourt.

323

Validity of simplified disease activity index using CRP titer in comparison to disease activity score-28 joints in Iraqi patients with active Rheumatoid arthritis  

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Full Text Available Objective: Various factors are known to determine the disease activity in patients with rheumatoid arthritis (RA. The ?simplified disease activity? index (SDAI is new tool of measurement of disease activity. The present study was designed to assess validity of SDAI using C-reactive protein (CRP titer in comparison to ?disease activity score in 28 joints? (DAS28 in Iraqi patients with active RA. Methods: Sixty nine Iraqi RA patients were included in this study. All patients were active and fulfilled the ACR (American College of Rheumatology classification criteria. Full history was taken and complete clinical examination was done for all patients. Patients' age, sex, number of swollen joints, visual analogue scale (VAS, and evaluators? global assessment (EGA were documented. Laboratory analysis included erythrocyte sedimentation rate (ESR, CRP, SDAI and DAS28 were measured to assess disease activity. Results: The results revealed direct significant correlation between SDAI and DAS28 (r = 0.903, p < 0.001, and reported a good agreement between SDAI and DAS28 (? = 0.777, p < 0.001. SDAI was found as a valid measure for disease activity using CRP as a screening test compared to DAS28 (AUC = 0.983, p < 0.001. Conclusion: SDAI is a valid and sensitive measure for assessment of rheumatoid arthritis disease activity that is comparable with the DAS28 using semi quantitative method to estimate CRP. [J Exp Integr Med 2012; 2(3.000: 231-236

Saad A. Hussain

2012-06-01

324

Decoding the differential biomarkers of Rheumatoid arthritis and Osteoarthritis: A functional genomics paradigm to design disease specific therapeutics  

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Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unidentified aetiology, chiefly affecting the synovial membranes of joints, cartilage, bone, bursa and tendon sheath. Osteoarthritis (OA) is a degenerative disorder and encompass different sets of pathogenic pathways than RA; however, it shows a medley of clinical manifestations or symptoms resembling RA. Hence, we intend to identify more disease specific biomarkers through the meta-analysis of microarray dataset...

Biswas, Sreyasi; Manikandan, Jayapal; Pushparaj, Peter Natesan

2011-01-01

325

A Comparison of the Effectiveness of Surgical and Nonsurgical Treatment of Legg-Calve-Perthes Disease: A Review of the Literature  

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Legg-Calve-Perthes disease (LCPD) is a degenerative condition of the hip joint characterised by idiopathic avascular necrosis of the femoral head. Loss of bone mass causes a degree of collapse of the joint and may result in deformity of the ball of the femur and the surface of the hip socket. A reduction in hip joint range of motion, alternation in growth of femoral head, and associated pain are most important problems associated with this disease. Various treatment methods are currently in u...

2012-01-01

326

Determinants of Early Life Leptin Levels and Later Life Degenerative Outcomes  

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The early (intrauterine and neonatal) life environment plays an important role in programming the susceptibility in later life to chronic degenerative diseases, such as obesity, cardiovascular diseases, diabetes mellitus, cancer and osteoporosis.Among other hormones, leptin plays a major role in the regulation of the overall metabolism and has multiple neuroendocrine (adeno- and neuro-hypophysis axes and the hypothalamus–pituitary–adrenal axis) and immune functions.The hormone exerts its ...

Alexe, Delia-marina; Syridou, Garyfallia; Petridou, Eleni Th

2006-01-01

327

Diagnosis and conservative management of degenerative lumbar spondylolisthesis  

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Degenerative spondylolisthesis (DS) is a disorder that causes the slip of one vertebral body over the one below due to degenerative changes in the spine. Lumbar DS is a major cause of spinal canal stenosis and is often related to low back and leg pain. We reviewed the symptoms, prognosis and conservative treatments for symptoms associated with DS. PubMed and MEDLINE databases (1950–2007) were searched for the key words “spondylolisthesis”, “pseudospondylolisthesis”, “degenerative ...

2008-01-01

328

Current developments in imaging of the temporomandibular joint  

International Nuclear Information System (INIS)

The purpose of this paper is to provide a simple systematic approach to the diagnosis of polyarticular and monoarticular disease. The first part deals with common polyarticular disease, specifically the inflammatory, crystalline, and degenerative arthritides. The changes seen around the joint, as well as the distribution of the changes, characteristics of each anthropathy are demonstrated through the use of hand films. The second part of the presentation addresses the less well-known monoarticular diseases, specifically disorders that are diagnosed primarily by the radiologist rather than the clinician. These disorders include infectious arthritis, pigmented villonodular synovitis, synovial chondromatosis, and neuropathic arthropathy. The radiographic findings are not well known. Three categories of radiographic abnormalities are emphasized as an aid to diagnosis: juxtaarticular osteoporosis, subchondral cysts, and synovial calcification and debris

1987-12-04

329

The evolution and concepts of joint-preserving surgery of the hip.  

Science.gov (United States)

The use of joint-preserving surgery of the hip has been largely abandoned since the introduction of total hip replacement. However, with the modification of such techniques as pelvic osteotomy, and the introduction of intracapsular procedures such as surgical hip dislocation and arthroscopy, previously unexpected options for the surgical treatment of sequelae of childhood conditions, including developmental dysplasia of the hip, slipped upper femoral epiphysis and Perthes' disease, have become available. Moreover, femoroacetabular impingement has been identified as a significant aetiological factor in the development of osteoarthritis in many hips previously considered to suffer from primary osteoarthritis. As mechanical causes of degenerative joint disease are now recognised earlier in the disease process, these techniques may be used to decelerate or even prevent progression to osteoarthritis. We review the recent development of these concepts and the associated surgical techniques. PMID:24395304

Leunig, M; Ganz, R

2014-01-01

330

Diagnostic steps in disc luxations and other frequent diseases of the temporomandibular joint  

International Nuclear Information System (INIS)

Modern diagnosis of the temporomandibular joint (TMJ) consists of multiple steps, based on each other and amplifying one another. The first step is the clinical functional analysis, respecting general medical as well as specific dental aspects. If need arises electronic axiography, recording the movement of TMJ hingeaxis, is being added as well as occlusal analysis on mounted plaster casts. In case of open questions at this point of analysis, magnetresonance- and computer-tomographic imaging is brought in. The present paper is an overview describing the current step by step diagnosis of TMJ disorders, with special attention to luxation-reduction mechanism in the joints. (orig.)

2001-09-01

331

Induction of degenerative brain lesions after adoptive transfer of brain lymphocytes from Borna disease virus-infected rats: presence of CD8+ T cells and perforin mRNA.  

Science.gov (United States)

Lymphocytes were isolated from the brains of Borna disease virus-infected donor Lewis rats at various time points after infection. Cell populations were characterized by cytofluorometry, with special emphasis on CD4+ and CD8+ cells. Testing of isolated lymphocytes revealed major histocompatibility complex class I-restricted cytotoxic activity. Reverse transcription-PCR analyses of brain homogenates of infected donors revealed the presence of CD8 mRNA after day 11 of infection and of perforin mRNA between days 13 and 25 after infection. Adoptive transfers of lymphocytes isolated from the brain at days 13 and 21 resulted in severe neurological symptoms, resembling experimental Borna disease. The onset of disease was dependent on the cell numbers transferred and was clearly related to the appearance of T cells in the brain. CD8+ T cells were found in the parenchyma, whereas CD4+ T cells were found predominantly in perivascular locations. A disseminated lymphocytic infiltration in the parenchyma was accompanied by severe morphological alterations, including significant necrosis of neurons. Furthermore, a prominent spongiform-like degeneration was observed; this increased over time and finally resulted in severe cortical brain atrophy. Lymphocytes obtained during the beginning chronic phase of experimental Borna disease in rats had no significant cytolytic capacity in vitro and were also not able to induce neurological symptoms typical of Borna disease after adoptive transfer. The data presented here show for the first time that lymphocytes isolated from the site of the inflammatory lesions, namely, the brains of diseased rats, induce the immunopathological reaction and cause Borna disease. After transfer, the pathological alterations induced in the recipients exactly reflect those observed during experimentally induced Borna disease in rats, including necrosis of neurons and glial cells and gross degeneration resulting in cortical brain atrophy. Evidence that the immunopathology of Borna disease is closely related to the presence of CD8+ T cells in the brain parenchyma is provided. PMID:9032377

Sobbe, M; Bilzer, T; Gommel, S; Nöske, K; Planz, O; Stitz, L

1997-03-01

332

Induction of degenerative brain lesions after adoptive transfer of brain lymphocytes from Borna disease virus-infected rats: presence of CD8+ T cells and perforin mRNA.  

Science.gov (United States)

Lymphocytes were isolated from the brains of Borna disease virus-infected donor Lewis rats at various time points after infection. Cell populations were characterized by cytofluorometry, with special emphasis on CD4+ and CD8+ cells. Testing of isolated lymphocytes revealed major histocompatibility complex class I-restricted cytotoxic activity. Reverse transcription-PCR analyses of brain homogenates of infected donors revealed the presence of CD8 mRNA after day 11 of infection and of perforin mRNA between days 13 and 25 after infection. Adoptive transfers of lymphocytes isolated from the brain at days 13 and 21 resulted in severe neurological symptoms, resembling experimental Borna disease. The onset of disease was dependent on the cell numbers transferred and was clearly related to the appearance of T cells in the brain. CD8+ T cells were found in the parenchyma, whereas CD4+ T cells were found predominantly in perivascular locations. A disseminated lymphocytic infiltration in the parenchyma was accompanied by severe morphological alterations, including significant necrosis of neurons. Furthermore, a prominent spongiform-like degeneration was observed; this increased over time and finally resulted in severe cortical brain atrophy. Lymphocytes obtained during the beginning chronic phase of experimental Borna disease in rats had no significant cytolytic capacity in vitro and were also not able to induce neurological symptoms typical of Borna disease after adoptive transfer. The data presented here show for the first time that lymphocytes isolated from the site of the inflammatory lesions, namely, the brains of diseased rats, induce the immunopathological reaction and cause Borna disease. After transfer, the pathological alterations induced in the recipients exactly reflect those observed during experimentally induced Borna disease in rats, including necrosis of neurons and glial cells and gross degeneration resulting in cortical brain atrophy. Evidence that the immunopathology of Borna disease is closely related to the presence of CD8+ T cells in the brain parenchyma is provided.

Sobbe, M; Bilzer, T; Gommel, S; Noske, K; Planz, O; Stitz, L

1997-01-01

333

Avaliação clínica e funcional no pré-operatório de doenças degenerativas da coluna vertebral Evaluación clínica y funcional en el preoperatorio de patologías degenerativas de columna Clinical and functional evaluation in preoperative period of degenerative disease spine surgery  

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Full Text Available OBJETIVO: a utilização de instrumentos de avaliação clínica e funcional nos pacientes com doenças da coluna vertebral pode determinar a evolução e predizer o desfecho pós-operatório. O objetivo deste estudo foi descrever a metodologia de avaliação de doenças degenerativas espinhais e verificar os resultados. MÉTODOS: após a indicação de tratamento cirúrgico nos pacientes com doenças das colunas lombar e cervical, os mesmos foram informados dos objetivos do estudo e convidados a participar. Os questionários foram respondidos no consultório médico, onde possíveis dúvidas surgidas durante o preenchimento eram esclarecidas por uma pessoa treinada não envolvida com a cirurgia. Todos os instrumentos de avaliação usados eram autoaplicativos. Foram utilizados a escala numérica de dor, o Questionário de Qualidade de Vida SF-36, o Questionário de Evitação por Medos e Crenças (FABq, o Inventário de Depressão de Beck (BDI, a Escala de Depressão e Ansiedade Hospitalar (HAD, o Índice de Incapacidade Oswestry (ODI e o Índice de Disfunção Relacionado ao Pescoço (NDI. RESULTADOS: foram avaliados 220 pacientes com doenças da coluna lombar e 32 da cervical. A prevalência de depressão segundo o BDI foi de 28,0% e de 31,2% em pacientes com doença cirúrgica lombar e cervical, e a prevalência de ansiedade pelo HAD-A de 40,1% e 46,9%, respectivamente. A média do ODI foi de 46,5, e a do NDI, de 25,4. Quanto ao preenchimento dos questionários, a maioria dos pacientes, uma vez instruídos, não apresentou dificuldades em finalizá-los. O tempo médio de preenchimento de todos os instrumentos foi de 25 a 35 minutos. CONCLUSÕES: a utilização de instrumentos validados para avaliação dos pacientes com doenças degenerativas vertebrais é exequível e deve ser estimulada entre os cirurgiões que atuam no âmbito da coluna vertebral.OBJETIVO: la utilización de instrumentos de evaluación clínica y funcional de patologías vertebrales, además de determinar la evolución después del tratamiento, puede predecir el resultado postoperatorio. El objetivo de este estudio es describir la metodología de evaluación de patologías degenerativas de la columna y verificar los resultados. MÉTODOS: luego de la indicación del tratamiento quirúrgico, los pacientes son invitados a participar del estudio mediante firma de un término de consentimiento libre y claro. Los pacientes responden los cuestionarios en el consultorio médico y son auxiliados cuanto a dudas al completarlo por una persona no involucrada con la cirugía. Todos los instrumentos de evaluación utilizados son auto-aplicativos. Se utilizan: escala numérica del dolor (NRS, Cuestionario SF-36, Cuestionario de Evitación por Miedos y Creencias (FABq, Inventario de Depresión de Beck (BDI, Escala de Depresión y Ansiedad Hospitalaria (HAD, Índice de Discapacidad Oswestry (ODI, Índice de Disfunción Relacionado al Cuello (NDI. RESULTADOS: se evaluaron 220 pacientes con patologías de la columna lumbar y 32 de la cervical. La prevalencia de depresión según el BDI fue del 28,0 y 31,2% en pacientes con enfermedad quirúrgica lumbar y cervical, y la prevalencia de ansiedad por el HAD-A del 40,1 y 46,9%, respectivamente. El promedio de ODI fue de 46,5 y del NDI de 25,4. Cuanto a la viabilidad de completar los cuestionarios, se observo que la mayoría de los pacientes, una vez instruidos cuanto a la manera de completarlos, no presenta dificultades para hacerlo. El tiempo promedio para completar todos los instrumentos es de 25 a 35 minutos. CONCLUSIÓN: la utilización de instrumentos validados para evaluación de los pacientes con enfermedades degenerativas vertebrales es viable y debe ser estimulada entre los cirujanos de columna.OBJECTIVE: the use of clinical and functional evaluation instruments for vertebral pathologies, besides determining how the situation evolves after treatment, can predict the postoperative outcome. The objective of this study was to describe the methodology to evaluate spinal degenerative pathologies a

Asdrubal Falavigna

2009-09-01

334

Suppression of pain and joint destruction by inhibition of the proteasome system in experimental osteoarthritis.  

Science.gov (United States)

Osteoarthritis is a degenerative joint disease with pain and loss of joint function as major pathological features. Recent studies show that proteasome inhibitors reduce pain in various pathological conditions. We evaluated the effects of MG132, a reversible proteasome inhibitor on pain and joint destruction in a rat model of osteoarthritis. Osteoarthritis was induced by intraarticular injection of monosodium iodoacetate into the rat knee. Knee joint stiffness was scored and nociception was evaluated by mechanical pressure applied to the respective hind paw. Knee joint destruction was assessed by radiological and histological analyses. Expression of matrix metalloproteinase-3 (MMP-3) was analyzed by quantitative reverse transcription polymerase chain reaction in the knee articular cartilage. Expression of substance P (SP) and calcitonin gene-related peptide (CGRP) was studied in the dorsal root ganglia (L4-L6) by quantitative reverse transcription polymerase chain reaction and in the knee joints by immunohistochemistry. Our results indicate that daily treatment of osteoarthritic rats with MG132 significantly increases their mobility while the swelling, pain thresholds, and pathological features of the affected joints were reduced. Furthermore, the upregulated expression of MMP-3, SP, and CGRP in the arthritic rats was normalized by MG132 administration. We conclude that the proteasome inhibitor MG132 reduces pain and joint destruction, probably by involving the peripheral nervous system, and that changes in SP and CGRP expression correlate with alterations in behavioural responses. Our findings suggest that nontoxic proteasome inhibitors may represent a novel pharmacotherapy for osteoarthritis. PMID:22018973

Ahmed, Aisha Siddiqah; Li, Jian; Erlandsson-Harris, Helena; Stark, André; Bakalkin, Georgy; Ahmed, Mahmood

2012-01-01

335

Computed tomography of sternoclavicular joint lesions in spondylarthropathies  

International Nuclear Information System (INIS)

To evaluate the computed tomography (CT) findings of inflammatory lesions of the sternoclavicular joints (SCJ) in spondylarthropathies. Design and patients. CT scans of the SCJs were obtained in 23 patients (group 1) with inflammatory SCJ lesions in spondylarthropathies. These scans were reviewed by four readers and compared with the CT scans of 23 matched controls (group 2). Each reader had to complete a 27-item grid. Results and conclusion. In the 23 patients of group 1, the mean number of observed signs was 5.3±4.2 higher (P<0.01) than in the group of 23 matched controls (2.4±1.6). Four signs were more frequently observed (P<0.05) in group 1: surrounded subchondral clavicular erosions and cysts, surrounded subchondral sternal cysts and sternal bone sclerosis. A cyst and/or an erosion was associated with hyperostosis and/or bone sclerosis in 9 of 23 patients in group 1. This association was not observed in group 2; the difference was significant (P<0.001). A cyst and/or an erosive lesion was observed 18 times in group 1 versus 11 times in group 2; the difference was significant (P<0.05). Conversely, signs of degenerative lesions (osteophytes, subchondral sclerosis, unevenness of joint surface) were no more frequently observed in controls than in group 1. This study emphasizes the diagnostic value of CT, in particular in the identification of inflammatory lesions, even when pre-existing degenerative disease is present. (orig.). With 3 figs., 2 tabs

1997-07-07

336

The role of imprint cytology in diagnosis of various bone and joint diseases.  

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Using imprint cytodiagnosis on 63 cases of bone and joint lesions, there was only one false negative result, with ten unsatisfactory smear preparations giving an overall accuracy of 82.25 per cent. Imprint cytodiagnosis is simple, cheap, rapid easy to perform and interpret because of its better cytomorphological evaluation. The accuracy rate is high when used in conjunction with various cytochemical stains.

Arora H; Solanki R; Poònia I

1990-01-01

337

Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on Nutrition and autoimmune disease Nutrition in Crohn s disease  

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The exact aetiology of Crohn's disease remains unknown. The consensus is that the disease results from a complex interaction between genes, immunity and environmental factors. Diet is attractive, in theory, as an environmental risk factor in the aetiology of the disease. The epidemiological data, often impeded by methodological issues, have failed to confirm a direct link between pre-diet illness and the development of Crohn's disease. Once diagnosed, however, nutrition has an important role ...

2009-01-01

338

Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis  

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Abstract Background Recent data have suggested a relationship between acute arthritic pain and acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The purpose of this study was to clarify the role of ASIC3 in a rat model of osteoarthritis (OA) which is considered a degenerative rather than an inflammatory disease. Methods We induced OA via intra-articular mono-iodoacetate (MIA) injection, and evaluated pain-related behavior...

Izumi Masashi; Ikeuchi Masahiko; Ji Qinghui; Tani Toshikazu

2012-01-01

339

[Hydrocephalic and/or degenerative dementia].  

Science.gov (United States)

The authors report ten cases of progressive dementia. Nine are associated with gait disturbances and seven with urinary incontinence. Despite the severity of dementia and Ct Scan signs of cortical atrophy, magnitude of neuroradiological ventricular dilatation and ventricular reflux at isotopic cisternography lead to shunt therapy. After ventricular shunting of CSF, a follow-up at short and long terms shows different clinical evolutions: two transitory improvements, three cases without change and five worsening. Retrospective clinical study of these cases in which diagnosis leads to a degenerative process of the Alzheimer type shows atypical premorbid neuropsychological characteristics by a normal-pressure hydrocephalus. In fact, in the ten cases preoperative neuropsychological investigation shows, at various levels, aphasic, alexic and agraphic signs. Their occurrence in the clinical picture represents an essential contribution to differential diagnosis. PMID:2516970

De Mol, J; Retif, J; Brihaye, J

1989-01-01

340

The relationship between the cerebral blood flow, oxygen consumption and glucose metabolism in primary degenerative dementia  

International Nuclear Information System (INIS)

The CBF, CMRO2 and CMRGlu were measured in patients with primary degenerative dementia including 5 patients with dementia of Alzheimer's type and 4 patients with Pick's disease, and then the correlation between the cerebral blood flow and energy metabolism was evaluated. The control subjects consisted of 5 age-matched normal volunteers. The CBF, CMRO2 and CMRGlu decreased in the bilateral frontal, temporal and parietal regions in the patients with Alzheimer's dementia, while they decreased in the bilateral frontal and temporal regions in the patients with Pick's disease. Both the CBF and CMRO2 were closely correlated with each other. However, the CMRGlu was more severely impaired than the CBF or CMRO2 in both pathological conditions. These results suggested that CMRGlu began to decrease before the reduction of the aerobic metabolism and thus measuring the CMRGlu is considered to be the most sensitive method for detecting abnormal regions in primary degenerative dementia. (author)

1995-03-01

 
 
 
 
341

Comparation of levels of anxiety and depression in patients with autommune and chronic-degenerative rheumatic: preliminary data  

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Scientific research on rheumatic diseases was often focused on the link between psychological features and disease. Depression and anxiety are frequently observed with an higher incidence among rheumatic patients in comparison to general population. In autoimmune diseases, such as rheumatoid arthritis, an important role for psychiatric symptoms could be played by the alteration of cytokines levels. In the chronic-degenerative diseases, psychological factors such as stress and depression, can ...

2011-01-01

342

Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases  

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Full Text Available Abstract Background Genome-wide association studies (GWAS have provided a large set of genetic loci influencing the risk for many common diseases. Association studies typically analyze one specific trait in single populations in an isolated fashion without taking into account the potential phenotypic and genetic correlation between traits. However, GWA data can be efficiently used to identify overlapping loci with analogous or contrasting effects on different diseases. Results Here, we describe a new approach to systematically prioritize and interpret available GWA data. We focus on the analysis of joint and disjoint genetic determinants across diseases. Using network analysis, we show that variant-based approaches are superior to locus-based analyses. In addition, we provide a prioritization of disease loci based on network properties and discuss the roles of hub loci across several diseases. We demonstrate that, in general, agonistic associations appear to reflect current disease classifications, and present the potential use of effect sizes in refining and revising these agonistic signals. We further identify potential branching points in disease etiologies based on antagonistic variants and describe plausible small-scale models of the underlying molecular switches. Conclusions The observation that a surprisingly high fraction (>15% of the SNPs considered in our study are associated both agonistically and antagonistically with related as well as unrelated disorders indicates that the molecular mechanisms influencing causes and progress of human diseases are in part interrelated. Genetic overlaps between two diseases also suggest the importance of the affected entities in the specific pathogenic pathways and should be investigated further.

Arnold Matthias

2012-09-01

343

Joint Hypermobility Syndrome and Dysautonomia: Expanding Spectrum of Disease Presentation and Manifestation  

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The varying clinical presentations of not so well recognized diseases, which continue to haunt patients is well described in the above quotes. Clinicians may not recognize associated subtle early presentations of the disease, till the disease has fully manifested itself. Of all the disorders of human body, autonomic syndromes are still the least understood. Presentation and association of autonomic diseases with other disorders may be so varied and subtle that clinicians may fail to recognize...

2010-01-01

344

Arthroscopical treatment of elbow joint disease Tratamento artroscópico de doenças da articulação do cotovelo  

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Elbow arthroscopy was performed in 30 dogs of different breeds. The procedure was performed bilaterally in 20 of these dogs, yielding a total of 50 joints. Different lesions were found, varying from cartilage fissures (8) to fragmentation (42) of medial coronoid process (FCP) of the ulna. Osteochondritis dissecans (OCD) of the humerus medial condyle was associated in four of them. All of these cases displayed varying degrees of synovitis. Osteoarthrosis (OA) in varying intensity was observed ...

2012-01-01

345

Laser transillumination of interphalangeal joints of women suffering from rheumatoid diseases  

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Full Text Available Experimental set-up consisted of He-Ne laser with optics for collimated illumination, special holder for placing the finger (perpendicular to optical axis, dorsal or ventral site towards camera, and CCD camera was constructed for performing the transillumination examination of proximal interphalangeal joints of 19 healthy female adult volunteers and 21 female patients suffering from joints inflammation. The transillumination images of ill and healthy subjects were compared by histogram analysis. The images were captured from dorsal and ventral side of the fingers. It was found that the mean grey level values in images taken at the dorsal side (laser beam travels from the ventral side are lower than for the opposite direction. It was also concluded that healthy volunteers have joints more transparent to visible light, so the mean grey level values in captured images were higher. It was possible to observe the changes in images intensity of patients subjected to the anti-inflammation therapy, what may allow for monitoring the efficacy of the therapy.

Halina Podbielska

2007-01-01

346

Degenerative dementia: nosological aspects and results of single photon emission computed tomography  

International Nuclear Information System (INIS)

Ten years ago, the diagnosis discussion of a dementia case for the old patient was limited to two pathologies: the Alzheimer illness and the Pick illness. During these last years, the frame of these primary degenerative dementia has fallen into pieces. The different diseases and the results got with single photon emission computed tomography are discussed. for example: fronto-temporal dementia, primary progressive aphasia, progressive apraxia, visio-spatial dysfunction, dementia at Lewy's bodies, or cortico-basal degeneration. (N.C.)

1999-12-01

347

Central motor conduction in degenerative ataxic disorders: a magnetic stimulation study.  

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Central motor conduction to small hand muscles was measured using magnetic stimulation of the motor cortex and electrical stimulation of proximal motor roots in 11 patients with Friedreich's ataxia, 10 patients with early onset cerebellar ataxia with retained tendon reflexes (EOCA) and 13 patients with late onset degenerative cerebellar disease (LOCD). Central motor conduction was abnormal in 91% with Friedreich's ataxia, 70% with EOCA and 38% with LOCD. Central motor conduction abnormalities...

Claus, D.; Harding, A. E.; Hess, C. W.; Mills, K. R.; Murray, N. M.; Thomas, P. K.

1988-01-01

348

Obesity and increased burden of hip and knee joint disease in Australia: Results from a national survey  

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Full Text Available Abstract Background Research involving more representative samples is needed to extend our understanding of the broader impact of obesity in hip or knee joint disease (arthritis and OA beyond clinical settings. Although population-based research has been conducted in the United States, how these findings translate to other countries is unclear. Using a national approach, this study explored associations between obesity and the burden of hip and knee joint disease in Australia (in terms of prevalence, pain, stiffness, function, Health-Related Quality of Life (HRQoL and disease severity. Methods A random sample of 5000 Australians (?39 years from the federal electoral roll was invited to complete a mailed questionnaire to identify doctor-diagnosed hip arthritis, hip OA, knee arthritis and knee OA and evaluate the burden of these conditions. Validated questionnaires included the WOMAC Index, Assessment of Quality of Life instrument and Multi-Attribute Prioritisation Tool. Body Mass Index (BMI was classified into underweight/normal weight (?24.99 kg/m2, overweight (25–29.99 or obese (?30. Multiple logistic regression was used to estimate odds of arthritis and OA, with demographic and socioeconomic variables included in the models. Associations between BMI and other variables were investigated using analysis of covariance, with adjustment for age and sex. Results Data were available from 1,157 participants (23%. Overweight participants had increased odds of knee arthritis (adjusted OR (AOR 1.87, 95%CI 1.14-3.07 and knee OA (AOR 2.11, 95%CI 1.07-4.15. Obesity was associated with higher prevalence of hip arthritis (AOR 2.18, 95%CI 1.17-4.06, knee arthritis (AOR 5.47, 95%CI 3.35-8.95 and knee OA (AOR 7.35, 95%CI 3.85-14.02. Of those with arthritis or OA, obese individuals reported more pain (for hip arthritis, hip OA and knee OA, greater stiffness (for hip arthritis, knee arthritis and knee OA, worse function (all diagnoses, lower HRQoL (for hip arthritis and hip OA and greater disease severity (all diagnoses. Conclusions This national study has demonstrated that the odds of arthritis and OA was up to 7 times higher for obese individuals, compared with those classified as underweight/normal weight. Concurrent obesity and joint disease had a marked impact on several key aspects of wellbeing, highlighting the need for public health interventions.

Ackerman Ilana N

2012-12-01

349

Sonography of the knee joint?  

Science.gov (United States)

The aim of this article is to review the sonographic appearances of common disorders involving the knee joint. Ultrasound is a sensitive method for diagnosis of tendon injuries. Injured ligaments appear swollen with mixed echogenicity. Meniscal injuries and muscle tears can be easily diagnosed. Ultrasound shows synovial thickening and effusion in inflammatory arthropathy and erosions of the articular surface in degenerative arthritis. It can be used effectively in the detection of rheumatoid arthritic activity and for grading degenerative arthritis lesions. Cystic lesions, as well as benign and malignant soft-tissue masses, are clearly delineated. Ultrasound is a safe noninvasive imaging modality that can be used for diagnosis of different disorders involving the knee joint.

Razek, A.A.K.A.; Fouda, N.S.; Elmetwaley, N.; Elbogdady, E.

2009-01-01

350

Acquired degenerative changes of the intervertebral segments at and suprajacent to the lumbosacral junction A radioanatomic analysis of the nondiscal structures of the spinal column and perispinal soft tissues  

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A review of the imaging features of normal and degenerative anatomy of the spine on medical imaging studies shows features that have been largely overlooked or poorly understood by the imaging community in recent years. The imaging methods reviewed included computed tomography (CT) with multiplanar reconstructions and magnetic resonance imaging (MRI). A routine part of the MRI examination included fat-suppressed T2 weighted fast-spin- or turbo-spin-echo acquisitions. As compared to the normal features in asymptomatic volunteers, alterations in the observed CT/MRI morphology and MR signal characteristics were sought in symptomatic individuals. Findings in symptomatic subjects which departed from the normal anatomic features of the posterior spinal elements in asymptomatic volunteers included: rupture of the interspinous ligament(s), neoarthrosis of the interspinous space with perispinous cyst formation, posterior spinal facet (zygapophyseal joint) arthrosis, related central spinal canal, lateral recess (subarticular zone) and neural foramen stenosis, posterior element alterations associated with various forms of spondylolisthesis, and perispinal muscle rupture/degeneration. These findings indicate that the posterior elements are major locations of degenerative spinal and perispinal disease that may accompany or even precede degenerative disc disease. Although not as yet proven as a reliable source of patient signs and symptoms in all individuals, because these observations may be seen in patients with radicular, referred and/or local low back pain, they should be considered in the evaluation of the symptomatic patient presenting with a clinical lumbosacral syndrome. Imaging recommendations, in addition to the usual close scrutiny of these posterior spinal elements and perispinal soft tissues on CT and MRI, include the acquisition of high-resolution multiplanar CT reconstructions, and fat-suppressed T2 weighted fast-spin- or turbo-spin-echo sequence MRI in at least one plane in every examination of the lumbar spine.

Jinkins, J. Randy E-mail: jrjinkins@aol.com

2004-05-01

351

Environmental Radon Gas and Degenerative Conditions An Overview  

International Nuclear Information System (INIS)

Radon, a naturally occurring radioactive gas, has variable distribution in the environment as a decay product of uranium occurring in a wide range of rocks, soils and building materials. Although radon dissipates rapidly in outdoor air, it concentrates in the built environment, and inhalation of 222Rn and its progeny 218Po and 214Po is believed to provide the majority of the radioactive dose to the respiratory system. While the connection between radon and lung cancer has long been recognised and investigated, recent studies have highlighted potential links between radon and other conditions, among them Multiple Sclerosis, Alzheimer and Parkinson Diseases, and Paget Disease of Bone. A strong case exists for clarifying the relationship between radon and these other conditions, not least since radon remediation to reduce lung cancer may conceivably have additional benefits hitherto unrecognized. The present status of the postulated links between environmental radon gas and degenerative conditions is reviewed, and recommendations for further research into levering current anti-radon campaigns are made. (authors)

2006-05-15

352

Sulfato de condroitina e hialuronato de sódio no tratamento da doença articular degenerativa experimental em cães: aspectos clínicos e radiológicos Chondroitin sulfate and sodium hialuronate in treatment of the degenerative joint disease in dogs: clinical and radiological aspects  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Avaliaram-se clínica e radiograficamente os efeitos do sulfato de condroitina e do hialuronato de sódio no tratamento da articulação femorotibiopatelar de cães com doença articular degenerativa (DAD) induzida experimentalmente. Foram utilizados 15 cães, sem raça definida, de ambos os sexos, pesando entre 18 e 25 kg, submetidos à secção artroscópica do ligamento cruzado cranial (LCCr) para desestabilização articular e indução da DAD. Após três semanas de instabilidade articul...

2003-01-01

353

Arthroscopical treatment of elbow joint disease / Tratamento artroscópico de doenças da articulação do cotovelo  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Artroscopia do cotovelo foi realizada em 30 cães de diferentes raças, bilateral em 20, totalizando 50 articulações. Foram encontradas diferentes lesões que variavam de fissuras na cartilagem (8) a fragmentação (42). Osteocondrose dissecante (OCD) do côndilo medial do úmero estava associada à fragmen [...] tação do processo coronoide (FCP) medial da ulna em quatro casos. Em todas articulações verificou-se sinovite em graus variados. Osteoartrose (OA) de diferentes intensidades foi observada em 44 articulações. O tratamento foi instituído na maioria dos casos, dois a quatro meses após a manifestação dos sinais clínicos. Recuperação clínica satisfatória ocorreu naqueles com mínima lesão articular, cujo diagnóstico e tratamento se fizeram dentro de quatro semanas após a manifestação clínica. O diagnóstico precoce e o tratamento artroscópico previne a osteoartrose e preserva a função locomotora. Abstract in english Elbow arthroscopy was performed in 30 dogs of different breeds. The procedure was performed bilaterally in 20 of these dogs, yielding a total of 50 joints. Different lesions were found, varying from cartilage fissures (8) to fragmentation (42) of medial coronoid process (FCP) of the ulna. Osteochond [...] ritis dissecans (OCD) of the humerus medial condyle was associated in four of them. All of these cases displayed varying degrees of synovitis. Osteoarthrosis (OA) in varying intensity was observed in 44 joints. The majority of cases were treated two to four months after the manifestation of clinical signs. Good clinical recovery occurred in dogs with minimal joint lesions, where these were diagnosed and treated within four weeks of the onset of clinical symptoms. Early diagnosis and arthroscopic treatment prevent osteoarthrosis and preserve locomotor function.

C.M.F., Rezende; E.G., Melo; C., Malm; V.A., Gheller.

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Arthroscopical treatment of elbow joint disease Tratamento artroscópico de doenças da articulação do cotovelo  

Directory of Open Access Journals (Sweden)

Full Text Available Elbow arthroscopy was performed in 30 dogs of different breeds. The procedure was performed bilaterally in 20 of these dogs, yielding a total of 50 joints. Different lesions were found, varying from cartilage fissures (8 to fragmentation (42 of medial coronoid process (FCP of the ulna. Osteochondritis dissecans (OCD of the humerus medial condyle was associated in four of them. All of these cases displayed varying degrees of synovitis. Osteoarthrosis (OA in varying intensity was observed in 44 joints. The majority of cases were treated two to four months after the manifestation of clinical signs. Good clinical recovery occurred in dogs with minimal joint lesions, where these were diagnosed and treated within four weeks of the onset of clinical symptoms. Early diagnosis and arthroscopic treatment prevent osteoarthrosis and preserve locomotor function.Artroscopia do cotovelo foi realizada em 30 cães de diferentes raças, bilateral em 20, totalizando 50 articulações. Foram encontradas diferentes lesões que variavam de fissuras na cartilagem (8 a fragmentação (42. Osteocondrose dissecante (OCD do côndilo medial do úmero estava associada à fragmentação do processo coronoide (FCP medial da ulna em quatro casos. Em todas articulações verificou-se sinovite em graus variados. Osteoartrose (OA de diferentes intensidades foi observada em 44 articulações. O tratamento foi instituído na maioria dos casos, dois a quatro meses após a manifestação dos sinais clínicos. Recuperação clínica satisfatória ocorreu naqueles com mínima lesão articular, cujo diagnóstico e tratamento se fizeram dentro de quatro semanas após a manifestação clínica. O diagnóstico precoce e o tratamento artroscópico previne a osteoartrose e preserva a função locomotora.

C.M.F. Rezende

2012-02-01

355

Sonography of the knee joint?  

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The aim of this article is to review the sonographic appearances of common disorders involving the knee joint. Ultrasound is a sensitive method for diagnosis of tendon injuries. Injured ligaments appear swollen with mixed echogenicity. Meniscal injuries and muscle tears can be easily diagnosed. Ultrasound shows synovial thickening and effusion in inflammatory arthropathy and erosions of the articular surface in degenerative arthritis. It can be used effectively in the detection of rheumatoid ...

Razek, A. A. K. A.; Fouda, N. S.; Elmetwaley, N.; Elbogdady, E.

2009-01-01

356

Studies of computed tomography as a contribution to differential diagnosis between dementia due to cerebrovascular disease (multi-infract type) and due to primarily degenerative cerebral atrophy (Alzheimers type)  

Energy Technology Data Exchange (ETDEWEB)

Studies of computed tomography were performed in 367 patients diagnosed as dementia clinically. The mean age was 70.1 years. By the clinicians 240 were classified as senile dementia of Alzheimer's type, 79 as multiinfarct dementia, and 48 were not determined definitely. In 3%, the CT studies did detect treatable causes like tum