damaged duramater cardiac: Topics by WorldWideScience.org

[sup 123]I-MIBG myocardial scintigraphy in diabetic patients. Relationship with [sup 201]Tl uptake and cardiac autonomic function

Primary cardiac angiosarcoma is a rare cardiac tumor. The initial clinical course is often asymptomatic, and metastatic disease is present in a majority of affected patients at diagnosis. We present...Full Text Available

2011-01-01

3

Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure

The purpose of this paper is to investigate the influence of diabetic myocardial damage (suspected myocardial damage; SMD) diagnosed by [sup 201]Tl-SPECT and diabetic cardiac autonomic neuropathy (AN) on myocardial MIBG uptake in patients with NIDDM. Eighty-seven diabetic patients divided into four subgroups: 23 with SMD (+) AN (+); 19 with SMD (+) AN (-); 27 with SMD (-) AN (+); 18 with SMD (-) AN (-), and 10 controls were studied. Both planar and SPECT images were taken at 30 minutes (early) and 3 hours (delayed) after [sup 123]I-MIBG injection. The heart to mediastinum uptake ratio (H/M) and washout ratio of [sup 123]I-MIBG (WR) were obtained from both planar images. Similarly, the difference between the [sup 201]Tl image and the [sup 123]I-MIBG image in the total uptake score (TUS) was taken as the difference in the total uptake score ([Delta]TUS) representing cardiac sympathetic denervation without ...

1998-12-01

4

Cardiac Rehabilitation for TIA Patients

BackgroundIsoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease. In this study, we compared the transcriptional response...Full Text Available

5

Point/counterpoint: dose-related issues in cardiac CT imaging

TIA (Transient Ischemic Attack)

2010-12-13

6

British Library Electronic Table of Contents (United Kingdom)

This manuscript reviews some of the more controversial dose-related issues in cardiac CT imaging. Discussion covers the relative merits of cardiac CT versus MR, advantages and concerns regarding gated versus nongated cardiac CT and advantages and concerns regarding the use of breast shields in girls undergoing cardiac CT imaging.

2011-01-01

7

Segmentation of Myocardial Boundaries in Tagged Cardiac MRI Using Active Contours: A Gradient-Based Approach Integrating Texture Analysis

Models of cardiac electromechanics based on individual hearts imaging data

The noninvasive assessment of cardiac function is of first importance for the diagnosis of cardiovascular diseases. Among all medical scanners only a few enables radiologists to evaluate the local cardiac...Full Text Available

2009-01-01

8

British Library Electronic Table of Contents (United Kingdom)

Current multi-scale computational models of ventricular electromechanics describe the full process of cardiac contraction on both the micro- and macro- scales including: the depolarization of cardiac cells, the release of calcium from intracellular stores, tension generation by cardiac myofilaments, and mechanical contraction of the whole heart. Such models are used to reveal basic mechanisms of cardiac contraction as well as the mechanisms of cardiac dysfunction in disease conditions. In this paper, we present a methodology to construct finite element electromechanical models of ventricular contraction with anatomically accurate ventricular geometry based on magnetic resonance and diffusion tensor magnetic resonance imaging of the heart. The electromechanical model couples detailed repres...

2011-01-01

9

Phospholemman: A Novel Cardiac Stress Protein

Cardiac arrhythmia in refrigerator repairmen exposed to fluorocarbons.

Phospholemman (PLM), a member of the FXYD family of regulators of ion transport, is a major sarcolemmal substrate for protein kinases A and C in cardiac and skeletal muscle. In the heart, PLM...Full Text Available

2010-08-01

10

Cardiac Enzymes, Renal Failure and Renal Transplantation

A field study of 89 refrigerator repairmen was carried out to ascertain whether occupational exposure to fluorocarbons induces cardiac arrhythmia. The concentrations of fluorocarbons in the breathing...Full Text Available

1990-03-01

11

Wasted breath: Dispatcher-assisted CPR in out-of-hospital cardiac arrest meets cardio-cerebral resuscitation.

Diagnostic accuracy of the currently available serum markers of cardiac injury, such as myoglobin, creatine kinase and its myocardial isoform, are altered in patients with renal failure. It is shown...Full Text Available

2006-03-01

12

Comparison of Manual Cardiopulmonary Resuscitation (CPR) Versus Automatic CPR Machine During Ambulance Transport.

PMID:21864481

2011-08-22

13

An In-Hospital Family Member Cardiopulmonary Resuscitation (CPR) Education Program

Cardiac Arrest; Cardiopulmonary Resuscitation

2006-03-28

14

A case of cardiac dysfunction associated with monoclonal gammopathy of undetermined significance.

Cardiac Arrest; Coronary Disease; Cardiovascular Risk Factors

2010-12-13

15

The Future of Induced Pluripotent Stem Cells for Cardiac Therapy and Drug Development.

Full Text Available

2009-04-01

16

Management of pitfalls for the successful clinical use of hypothermia treatment.

The field of stem cell research was revolutionized with the advent of induced pluripotent stem cells. By reprogramming somatic cells to pluripotent stem cells, most ethical concerns associated with the use of embryonic stem cells are overcome, such that many hopes from the stem cell field now seem a step closer to reality. Several methods and cell sources have been described to create induced pluripotent stem cells and we discuss their characteristics in terms of feasibility and efficiency. From these cells, cardiac progenitors and cardiomyocytes can be derived by several protocols and most recent advances as well as remaining limitations are being discussed. However in the short time period this technology has been around, evidence emerges that induced pluripotent stem cells may be more prone to genetic defects and maintain an epigenetic memory and thus may not be entirely the same as embryonic stem cells. Despite the lack of a complete fundamental understanding ...

2011-09-15

17

Spatiotemporal intracellular calcium dynamics during cardiac alternans

Therapeutic hypothermia is a promising method for controlling intracranial pressure (ICP) in severely brain-injured patients. However, clinical data regarding the effect of brain hypothermia on overall outcome of these patients is limited. This may be because there are specific pitfalls associated with the clinical management of induced hypothermia in patients with severe traumatic brain injury (TBI). These pitfalls may be avoided by preventing specific risk factors when cooling is induced and with rewarming. However, these risk factors have not been well systematically discussed in the literature. In this paper, three categories of clinical issues regarding the management of brain hypothermia are discussed: (1) stress-induced secondary brain injury mechanisms; (2) technical aspects of intensive care unit (ICU) cooling management; and (3) rewarming rates and methods. For patients with a Glasgow Coma Scale (GCS) score of less than 8, management of stress-induced insulin-resistant ...

2009-03-01

18

Sex modifies exercise and cardiac adaptation in mice

Cellular calcium transient alternans are beat-to-beat alternations in the peak cytosolic calcium concentration exhibited by cardiac cells during rapid electrical stimulation or under pathological conditions....Full Text Available

2009-09-01

19

Platelets in Hyperacute Rejection of Heterotopic Cardiac Allografts in Presensitized Dogs

How an individual’s sex and genetic background modify cardiac adaptation to increased workload is a topic of great interest. We systematically evaluated morphological and physiological...Full Text Available

2004-12-01

20

Pitfalls with the "chest compression-only" approach: the challenge of an unusual cause

Experiments were carried out to determine whether platelet aggregation plays a primary role in cardiac allograft hyperacute rejection, as has been observed in renal allograft hyperacute rejection....Full Text Available

1973-02-01

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Ordered Assembly of the Adhesive and Electrochemical Connections within Newly Formed Intercalated Disks in Primary Cultures of Adult Rat Cardiomyocytes

Chest compression-only (CC-only) is now incorporated in the Norwegian protocol for dispatch guided CPR (cardiopulmonary resuscitation) in cardiac arrest of presumed cardiac aetiology.We present...Full Text Available

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Multi-formalism modelling and simulation: application to cardiac modelling

The intercalated disk (ID) is a complex structure that electromechanically couples adjoining cardiac myocytes into a functional syncitium. The integrity of the disk is essential for normal cardiac function,...Full Text Available

2010-01-01

23

Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy

Cardiovascular modelling has been a major research subject for the last decades. Different cardiac models have been developed at a cellular level as well as at the whole organ level. Most of...Full Text Available

2004-01-01

24

Increased Expression and Activity of Matrix Metalloproteinases Characterize Embolic Cardiac Myxomas

The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with...Full Text Available

2008-11-01

25

Identification of Cardiac Myosin-binding Protein C as a Candidate Biomarker of Myocardial Infarction by Proteomics Analysis*

Tumor embolism occurs in 30 to 50% of all cases of cardiac myxoma, but the causes are still uncertain. Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade the extracellular matrix...Full Text Available

2005-06-01

26

Hypertrophy and Heart Failure in Mice Overexpressing the Cardiac Sodium-Calcium Exchanger

Acute myocardial infarction (AMI) is a common cause of death for which effective treatments are available provided that diagnosis is rapid. The current diagnostic gold standards are circulating cardiac...Full Text Available

2009-12-01

27

Elevated Cardiac Troponin I in Sepsis and Septic Shock: No Evidence for Thrombus Associated Myocardial Necrosis

Background:The cardiac sodium–calcium exchanger (NCX1) is a key sarcolemmal protein for the maintenance of calcium homeostasis in the heart. Since heart failure...Full Text Available

2007-05-01

28

Effects of Naja nivea venom on nerve, cardiac and skeletal muscle activity of the frog

BackgroundElevated cardiac troponin I (cTnI) is frequently observed in patients with severe sepsis and septic shock. However, the mechanisms underlying cTnI release in these patients...Full Text Available

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Double-Valve Libman-Sacks Endocarditis Causing Ventricular Fibrillation Cardiac Arrest

1. The effects of 1 mg/ml whole Naja nivea (Cape cobra) venom, and of three different toxins isolated from it, on spinal reflex excitability and cardiac and skeletal muscle activity...Full Text Available

1973-03-01

30

Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies

Libman-Sacks endocarditis is a well-known and rather common cardiac manifestation of systemic lupus erythematosus. Transesophageal and transthoracic echocardiography are the definitive imaging methods...Full Text Available

2011-01-01

31

Anxiety in Patients with Cardiac Disease.

Myocarditis, often initiated by viral infection, may progress to autoimmune inflammatory heart disease, dilated cardiomyopathy and heart failure. Although cardiac myosin is a dominant autoantigen...Full Text Available

2008-09-01

32

Access to Cardiac Interventional Services in Alabama and Mississippi: A Geographical Information System Analysis

Anxiety may cause adverse outcomes through physiologic pathways in patients with cardiac disease. The purpose of this dissertation was to investigate anxiety and its correlates in persons with acute myocardial infarction (AMI) and heart failure (HF). The ...

2005-01-01

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A high-speed network for cardiac image review.

ObjectiveThe objective of this study was to determine the contribution of distance to hospitals with cardiac interventional services (CIS) to county age-adjusted myocardial infarction...Full Text Available

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A Conserved Role for Phosphoinositide-3-Kinase but Not Akt Signaling in Mitochondrial Adaptations that Accompany Physiological Cardiac Hypertrophy

A high-speed fiber-based network for the transmission and display of digitized full-motion cardiac images has been developed. Based on Asynchronous Transfer Mode (ATM), the network is scaleable, meaning...Full Text Available

1994-01-01

35

Kenneth M. Baldwin - Astrobiology - NASA

Physiological cardiac hypertrophy is associated with mitochondrial adaptations that are characterized by activation of PGC-1α and increased fatty acid oxidative (FAO) capacity. It is...Full Text Available

2007-10-01

36

Usefulness of routine laboratory parameters in the decision to treat refractory cardiac arrest with extracorporeal life support

Feb 11, 1997 ... Dr. Baldwin's research focuses on understanding the mechanisms of skeletal and cardiac muscle adaptations to hormonal and activity ...

37

British Library Electronic Table of Contents (United Kingdom)

Aim: To evaluate the usefulness of routine laboratory parameters in the decision to treat refractory cardiac arrest patients with extracorporeal life support (ECLS). Methods: Sixty-six adults with witnessed cardiac arrest of cardiac origin unrelated to poisoning or hypothermia undergoing cardiopulmonary resuscitation without return of spontaneous circulation (duration: 155min [120-180], median, [25-75%-percentiles]) were included in a prospective cohort-study. ECLS was implemented under cardiac massage, using a centrifugal pump connected to a hollow-fiber membrane-oxygenator, aiming to maintain ECLS flow >=2.5l/min and mean arterial pressure >=60mmHg. Results: Forty-seven of 66 patients died within 24h from multiorgan failure and massive capillary leak. Of 19/66 patients who survived >=24h...

2011-01-01

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Comparison between DNA damage investigated by the ''Comet'' assay and chromosomal damage induced in human lymphocytes by radiation and chemicals

Transurethral Ultrasound Diffraction Tomography

Short communication.

1995-08-20

39

Repair of a Complex Congenital Cardiac Defect

... [5] GT Gullberg, RH Huesman, DNG Roy, J. Qi and BW Reutter, Esti- mation of the parameter covariance matrix for a one-compartment cardiac ...

2007-03-01

40

Medline Plus

... stenosis. It looks from the transesophageal and the 3-D echo that most of the problem is really ... posterior leaflet, which you can see on the 3-D echo image is a major source. The anterior ...

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Refilling Intracellular Calcium Stores

Perioperative Care of a Child with Transposition of the Great Arteries

Within the cardiac cell, the movements of calcium ions are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part...Full Text Available

2010-01-01

42

British Library Electronic Table of Contents (United Kingdom)

Opinion statement Because a minority of patients with D-transposition of the great arteries are diagnosed in utero by ultrasound, most present after delivery with cyanosis. In the absence of apparent lung disease, cyanotic neonates suspected of having a cardiac lesion should be immediately transferred to an intensive care unit at a pediatric tertiary care center for monitoring, resuscitation, and to define the cardiac anatomy and physiology. A prostaglandin E-1 infusion is usually initiated to maintain ductal patency and promote intra-cardiac mixing. In the past, balloon atrial septostomy (BAS) was routinely performed to enlarge the atrial septal defect and improve intra-cardiac mixing while the infants awaited surgery. Recent literature has reported an increase risk of stroke in neonates ...

2011-01-01

43

Metronome to Coordinate the Breaths and Cardiac Compressions Delivered by Minimally-Trained Caregivers During Two-Person CPR

Ion channels, transporters, and pumps as targets for heart failure

Astronaut crew medical officers (CMO) aboard the International Space Station (ISS) receive 40 hours

2005-01-01

44

FoxO, Autophagy, and Cardiac Remodeling

Congestive heart failure (CHF) is a leading cause of morbidity and mortality. CHF is marked by atrial and ventricular enlargement and reduced cardiac contractility, as well as an association...Full Text Available

2009-10-01

45

In response to changes in workload, the heart grows or shrinks. Indeed, the myocardium is capable of robust and rapid structural remodeling. In the setting of normal, physiological demand, the...Full Text Available

2010-08-01

46

Cardiac Malpositions

MR imaging study on external hydrocephalus in infants: extracerebral space developmental and pathological enlargement

Cardiac Malposition refers to any position of the heart other than a left-sided heart in a situs solitus individual. Associated cardiac malformations are so complex that even angiocardiographic and autopsy studies may not afford an accurate information. Although the terms and classifications used to describe the internal cardiac anatomy and their arterial connections in cardiac malpositions differ and tend to be confusing, common agreement exists on the need for a segmental approach to diagnosis. Authors present 18 cases of cardiac malpositions in which cardiac catheterization and angiocardiography were done at the Department of Radiology, Seoul National University Hospital between 1971 and 1979. Authors analyzed the clinical, radiographic, operative and autopsy findings with the emphasis on the angiocardiographic findings. The results are as follows: 1. Among ...

1979-06-01

47

Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH

Objective: To analyze the characteristics of external hydrocephalus in infancy with MR imaging, and to explore the cause of accumulation of extracerebral fluid and the relation with brain development. Methods: Conventional magnetic resonance T_1 weighted imaging (T_1WI) and T_2 weighted imaging (T_2WI) were performed in 46 infants aged 2 years or younger with external hydrocephalus (EH), and the results were analyzed. They were divided into 7 age groups. The width of extractable space was measured on T_2WI and compared with normal standard. Results: EH mainly resulted from infection, subdural hematoma or subarachnoid hemorrhage, HIE, which were 67.4% (31/46 cases) of the cases; EH with unknown cause were 26.1% (12/46 cases). EH was mainly located at the foreside of cerebral convexity, of which 80.4% (37/46 cases )was predominantly in the subarachnoid space, 8.7% (4/46 cases) in subdural space, 10.9% was subdural coexisted with subarachnoid collection. Duramater and ...

2006-05-01

48

Right-sided invasive metastatic thymoma of the heart

Increased oxidative stress is a known cause of cardiac dysfunction in animals and patients with diabetes, but the sources of reactive oxygen species [e.g., superoxide anion (O₂⁻)]...Full Text Available

2009-07-01

49

British Library Electronic Table of Contents (United Kingdom)

Cardiac tumours may display diverse symptoms through potential involvement of any structure of the heart. We describe a case of a highly malignant thymoma with involvement of different cardiac structures with important haemodynamic compromise. With the high sensitivity of transthoracic echocardiography for detection of intracardiac masses, computed tomography and magnetic resonance add essential structural preoperative information on the tumour and surrounding tissue as vessels, pleura, lung and mediastinum.

2011-01-01

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Radiation doses and somatic risk to patients during cardiac radiological procedures

New insights in LV torsion for the selection of cardiac resynchronisation therapy candidates

The radiation dose to a series of adult and paediatric patients undergoing cardiac catheterisations and adults having percutaneous transluminal coronary angioplasty has been measured/determined directly using lithium fluoride thermoluminescent dosemeters and indirectly using an air ionisation chamber which indicated exposure-area product. Somatic and genetic risks are estimated from the dosimetry results. It is suggested that the magnitude of the radiation hazard is negligible compared with other clinical hazards associated with these procedures. (author).

1986-01-01

51

British Library Electronic Table of Contents (United Kingdom)

Recent literature indicates that torsion of the left ventricle (LV) is a promising predictor for response to cardiac resynchronisation therapy (CRT). Among patients with severe heart failure, 45 to 75% of patients show rigid body rotation, where the base and apex rotate in the same direction, instead of normal, opposite rotation. The occurrence of this phenomenon seems to be a good indicator for response to CRT. From this review, it can be concluded that LV torsion might be a welcome addition to current selection criteria.

2011-01-01

52

Changes in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients receiving digoxin during the early phases of treatment of cardiac failure in regular rhythm and of atrial fibrillation.

The superconducting critical temperature of radiation damaged A-15 compounds

1 Measurements of the binding of 12-alpha-[3H]-digoxin to the membranes of intact erythrocytes, erythrocytic 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells...Full Text Available

1979-08-01

53

Skin Toxicity of Toluene on Liver Damage-Induced Rats

Not Available

1978-05-01

54

Estimation of the radiation damages of the Uppsala spectator detector

Full Text Available

2001-06-01

55

Effects of chronic swimming training on cardiac sarcolemmal function and composition.

No abstract prepared.

2002-03-01

56

The value of cardiac catheterization and cineangiography in infantile lobar emphysema

Cardiac contractile function is dependent on the integrity and function of the sarcolemmal membrane. Swimming exercise training is known to increase cardiac contractile performance. The purpose of the present study was to examine whether a swimming exercise program would alter sarcolemmal enzyme activity, ion flux, and composition in rat hearts. After approximately 11 wk of exercise training, cardiac myosin and actomyosin Ca2+-adenosinetriphosphatase (ATPase) activity was significantly higher in exercised rat hearts than in sedentary control rat hearts. Glycogen content was increased in plantaris and gastrocnemius muscles from exercised animals as was succinic dehydrogenase activity in gastrocnemius muscle of exercised rats in comparison to sedentary rat preparations. Sarcolemmal vesicles were isolated from hearts of exercise-trained and control rats. Sarcolemmal Na+-K+-ATPase and K+-p-nitrophenylphosphatase activities, ...

1989-04-01

57

Infant well-being following neonatal cardiac surgery

Lobar emphysema is an uncommon cause of respiratory distress in infancy. Congenital heart disease is seen in about 20% of the patients with infantile (congenital) lobar emphysema. We described six infants with lobar emphysema. In three of them a congenital heart disease was demonstrated by cardiac catheterization and cineangiography; two had a tetralogy of Fallot with right aortic arch and the third infant a ventricular septal defect. The pulmonary angiography showed stretching of the arteries with very poor filling of the peripheral arteries and a characteristic smaller pulmonary vein in the affected lobe. In all the six patients the pulmonary artery pressure was normal. All the patients underwent lobectomy with good results. We feel that a preoperative cardiac catheterization and cineangiography is of value in this very sick group of infants. (orig.).

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British Library Electronic Table of Contents (United Kingdom)

Aims and objectives.- To investigate infant well-being as measured by feeding and sleeping and parental support following discharge from the NICU in infants following major cardiac surgery. Background.- Infant feeding and sleeping have been identified as two of the most important concerns reported by parents. These concerns have been reported anecdotally for infants who have undergone cardiac surgery in the neonatal period. Design.- A prospective study using questionnaires and phone interviews followed a cohort of parents of neonates who underwent surgery in the neonatal period for congenital heart disease. Methods.- The study was conducted using validated questionnaires and phone interviews with a semi-structured questionnaire. The questionnaires were administered prior to discharge from ...

2011-01-01

59

Fluorocarbons and cardiac arrhythmia: does difluorodichloromethane (FC 12) inhibit cardiac metabolism

Cardiac Channelopathies and Sudden Infant Death Syndrome

Certain fluorocarbons, such as difluorodichloromethane (FC 12), depress the cardiovascular system by diminution of all the transmembrane ionic conductances in cardiac tissues. Does FC 12 also inhibit active transport and thus enzymatic activity and cellular energy. We measured phosphocreatine (PC), adenosine triphosphate (ATP) and cyclic adenosine monophosphate (AMPc) in rat hearts. Rats were randomly divided into 4 groups; 2 control groups: one breathing a mixture of oxygen (21%) and nitrogen (79%) (group C) and the other breathing the same mixture but simultaneously perfused with 1 microgram/kg/min. epinephrine (groupe E-C); 2 trial groups T and E-T where nitrogen was replaced by FC 12. The maximal FC 12 concentration of 720 micrograms/ml in arterial blood produced no significant difference in the concentrations of these three metabolites compared with controls.

1986-01-01

60

British Library Electronic Table of Contents (United Kingdom)

Abstract Sudden infant death syndrome (SIDS) is always a devastating and unexpected occurrence. SIDS is the leading cause of death in the first 6 months after birth in the industrialized world. Since the discovery in 1998 of long QT syndrome as an underlying substrate for SIDS, around 10-20% of SIDS cases have been proposed as being caused by genetic variants in either ion channel or ion channel-associated proteins. Until now, 10 cardiac channelopathy susceptibility genes have been found to be implicated in the pathogenesis of SIDS. Four of the genes encode cardiac ion channel a-subunits, 3 genes encode ion channel b-subunits, and 3 genes encode other channel-interacting proteins. All 10 genes have been associated with primary electrical heart diseases. SIDS may hereby be the initial sympt...

2011-01-01

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p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury

Validity of Cardiac Markers as Diagnostic and Prognostic Indicators of Complications in Patients undergoing Percutaneous Coronary Intervention

The side effects of cancer therapy on normal tissues limit the success of therapy. Generation of reactive oxygen species (ROS) has been implicated for numerous chemotherapeutic agents including doxorubicin...Full Text Available

62

Total prosthetic replacement of atrioventricular valves in the dog

ObjectivesThe aim of this study was to assess the diagnostic and prognostic value of heart-type fatty acid-binding protein (H-FABP) in elective percutaneous coronary intervention...Full Text Available

2010-04-01

63

Sternal plate fixation for sternal wound reconstruction: initial experience (Retrospective study)

The metal parts of cardiac valve prostheses cause reactions in the surrounding tissues of the heart. In some dogs rather abnormal reactions were found, and were attributed to corrosion of the stainless...Full Text Available

1972-01-01

64

Real-Time Assessment of Cardiac Perfusion, Coronary Angiography, and Acute Intravascular Thrombi Using Dual-Channel Near-Infrared Fluorescence Imaging

BackgroundMedian sternotomy infection and bony nonunion are two commonly described complications which occur in 0.4 - 5.1% of cardiac procedures. Although relatively infrequent,...Full Text Available

65

Radionuclide angiocardiography in the diagnosis of congenital heart disorders.

ObjectivesWe have developed an image-guided surgery system based on invisible near-infrared (NIR) fluorescent light. Presently, the only clinically-available NIR...Full Text Available

2009-07-01

66

Predicting outcome of rethoracotomy for suspected pericardial tamponade following cardio-thoracic surgery in the intensive care unit

Radionuclide angiocardiography provides a noninvasive assessment of cardiac function and blood flow through the heart and lungs. During the past three years, this procedure has been used at the Duke...Full Text Available

1981-06-01

67

Physical activity and physiological cardiac remodelling in a community setting: the Multi-Ethnic Study of Atherosclerosis (MESA)

ObjectivesPericardial tamponade after cardiac surgery is difficult to diagnose, thereby rendering timing of rethoracotomy hard. We aimed at identifying factors predicting the outcome...Full Text Available

68

Pericardial tamponade in a newborn following umbilical catheter insertion.

ObjectiveTo evaluate the association of physical activity with left ventricular structure and function in the general population in a community setting.Full Text Available

2010-01-01

69

Matching ATP Supply and Demand in Mammalian Heart: In Vivo, In Vitro and In Silico Perspectives

We present a case of cardiac tamponade following umbilical venous catheterization in a neonate, an uncommon, yet potentially fatal complication. Timely diagnosis by echocardiography and urgent pericardiocentesis proved lifesaving. PMID:21654008

2011-05-01

70

Lipotoxic heart disease in obese rats: Implications for human obesity

Although the heart rapidly adapts cardiac output to match the body’s circulatory demands, the regulatory mechanisms ensuring that sufficient ATP is available to perform the required...Full Text Available

2010-02-01

71

JAMA Patient Page: Cardiopulmonary Resuscitation (CPR)

To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG was...Full Text Available

2000-02-15

72

Force enhancement without changes in cross-bridge turnover kinetics: the effect of EMD 57033.

... of the American Medical Association JAMA PATIENT PAGE Cardiopulmonary Resuscitation W hen the heart stops beating (cardiac arrest), ... circulation (blood flow) returns or is restored. Providing cardiopulmonary resuscitation ( CPR ) is a way to keep some circulation ...

73

Evaluation of a diagnostic algorithm for heart disease in neonates.

The thiadiazinon derivative EMD 57033 has been found previously in cardiac muscle to increase isometric force generation without a proportional increase in fiber ATPase, thus causing a reduction in...Full Text Available

1997-01-01

74

Correlation between N-Terminal Pro-Brain Natriuretic Peptide and Doppler Echocardiographic Parameters of Left Ventricular Filling Pressure in Atrial Fibrillation

OBJECTIVE--To develop, test, and validate an algorithm for diagnosing disease in neonates during an over the telephone referral to a specialist cardiac centre. DESIGN--A draft algorithm requiring only...Full Text Available

1991-04-20

75

Clinical efficacy of the use of information technology in cardiology: initial results of angiographic teleconsultation in the Netherlands

BackgroundAtrial fibrillation (AF) is the most common cardiac arrhythmia with a population prevalence of about 1%. Natriuretic peptide level is elevated in patients with AF with...Full Text Available

2011-03-01

76

Chylopericardium after cardiac surgery can be treated successfully by oral dietary manipulation: a case report

Background With the increasing use of cineless diagnostic angiography laboratories, modern telecommunication networks provide an excellent opportunity to transfer dynamic cardiac...Full Text Available

2001-12-01

77

Carney-Complex: Multiple resections of recurrent cardiac myxoma

We report a case of chylopericardium after ascending aorta and aortic valve replacement, which presented as late tamponade. We discuss the various treatment options in this rare condition which can...Full Text Available

78

Cardiovascular magnetic resonance guided electrophysiology studies

We report a case of a female patient who was operated at the third relapse of an atrial myxoma caused by Carney complex. The difficult operation was performed without any complications despite extensive...Full Text Available

79

Cardiac Myosin Is a Substrate for Zipper-interacting Protein Kinase (ZIPK)*

Catheter ablation is a first line treatment for many cardiac arrhythmias and is generally performed under x-ray fluoroscopy guidance. However, current techniques for ablating complex arrhythmias such...Full Text Available

80

Automaticity and conduction properties of bio-artificial pacemakers assessed in an in vitro monolayer model of neonatal rat ventricular myocytes

Zipper-interacting protein kinase (ZIPK) is a member of the death-associated protein kinase family associated with apoptosis in nonmuscle cells where it phosphorylates myosin regulatory light chain...Full Text Available

2010-02-19

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Annular subvalvular left ventricular aneurysm in Bahia, Brazil.

AimsA better understanding of the ionic mechanisms for cardiac automaticity can lead to better strategies for engineering bio-artificial pacemakers. Here, we attempted to better...Full Text Available

2010-08-01

82

Angina with a normal coronary angiogram caused by amyloidosis

Two cases of left ventricular aneurysm, a 16-year-old black boy and a 23-year-old white girl, from Bahia, Brazil, are presented. In both patients there was enlargement of the cardiac silhouette and...Full Text Available

1976-10-01

83

An Integrated System for Total Cardiac Monitoring of the Critically Ill

A case of severe intractable angina pectoris with normal angiography is presented. Following video assisted thoracic sympathectomy the patient died of heart failure. Microvascular cardiac amyloidosis...Full Text Available

2004-09-01

84

A PDA-Based ECG Beat Detector for Home Cardiac Care.

An integrated system of micro-and mini-computers is described to acquire, analyze, store and report data on the total activity of the heart of a critically ill patient. Real-time beat and rhythm diagnoses...Full Text Available

1977-10-05

85

Features of laser damage to elastic polymers

Recent rapid growth in mobile computing technologies enables telemedicine applications to operate on mobile devices. Our focus is on the design of an integrated electrocardiogram (ECG) beat detector on a Personal Digital Assistant (PDA) platform for the health screening process. The ECG beat detector module will be supported by the PDA version of Personal Health Information Management System (PHIMS) and Facilitated Accurate Referral Management System (FARMS) through wireless network infrastructure as a home-based mobile cardiac monitoring solution. PMID:17282192

2005-01-01

86

From Attachment to Damage: Defined Genes of Candida albicans Mediate Adhesion, Invasion and Damage during Interaction with Oral Epithelial Cells

Threshold pump intensity values leading to irreversible damage to colored laser elements based on elastic polymers were measured. The damage to colored elastomers is connected with absorbing microinclusions but is independent of molecular absorption. It is shown that damage to the elastomers has a pronounced threshold character in contrast to the microdamage accumulation effect in glassy polymers. The damage threshold for elastomers is 1.5 times higher, which is connected with the absence of microstresses (characteristics for organic glasses) in the specimens. 13 references.

1988-03-01

87

DNA Damage during G2 Phase Does Not Affect Cell Cycle Progression of the Green Alga Scenedesmus quadricauda

Candida albicans frequently causes superficial infections by invading and damaging epithelial cells, but may also cause systemic infections by...Full Text Available

88

Beam-induced damage on diffractive hard X-ray optics

DNA damage is a threat to genomic integrity in all living organisms. Plants and green algae are particularly susceptible to DNA damage especially that caused by UV light, due to their light dependency...Full Text Available

89

Vertebrate Damage Control Research in Agriculture, Fiscal ...

The issue of beam-induced damage on diffractive hard X-ray optics is addressed. For this purpose a systematic study on the radiation damage induced by a high-power X-ray beam is carried out in both...Full Text Available

2010-11-01

90

Size Effects in Impact Damage of Composite Sandwich Panels Alan ...

... The revised work plan emphasized the research priorities of preharvest rodent damage to rice, the importance of postharvest food losses to rodents ...

1993-09-30

91

Radiation Damage Calculations for the FUBR and BEATRIX Irradiations of Lithium Compounds in EBR-II and FFTF

Wade. Jackson. - Army. VTD at NASA. Langley. ABSTRACT. Panel size has a large effect on the impact response and resultant damage level of honeycomb sandwich ...

92

Oxidative Damage and the Prevention of Age-Related Cataracts

Radiation Damage Calculations for the FUBR and BEATRIX Irradiations of Lithium Compunds in EBR-II and FFTF

1999-05-01

93

How can consequential damage to the generator be avoided in the case of large-scale turbine damage?; Wie lassen sich anlaesslich eines Turbinengrossschadens Folgeschaeden am Generator vermeiden?

PurposeCataracts are often considered to be an unavoidable consequence of aging. Oxidative damage is a major cause or consequence of cortical and nuclear cataracts, the most common...Full Text Available

2010-09-01

94

ESR study in radiation damage in pyrimidines. 3-year comprehensive progress report

Short communication

1997-08-01

95

The influence of different SPECT reconstruction algorithms on cardiac ischemia with the use artificial neural networks

General mechanisms of radiation damage to biomolecules was studied by using substituted pyrimidines, particularly barbituric acid derivatives.

96

The influence of copper(II) on radiation-induced damages to DNA

The aim of the study was the attempt to evaluate the influence of two different methods of cardiac perfusion SPECT reconstruction (FBP and ITW) on clinical efficacy in diagnosing the coronary artery disease as well as the cardiac ischemia detection in three areas of heart vascularized by main coronary arteries: LAD, LCX and RCA with the use of artificial neural networks (ANN). The study was performed retrospectively with the use of the diagnostic image records as well as clinical dataset of 43 patients. Myocardial perfusion stress/rest SPECT study and X-ray coronarography data were evaluated for each patient. The results of coronary angiography were considered the reference method. The cardiac SPECT data were reconstructed using the two different methods: filtered backprojection (FBP) and iterative Wallis method (ITW). The local perfusion deficits denominated in stress and rest study in three main vessel ...

97

The Damage of Microcontroller Devices due to Coupling Effects under High Power Electromagnetic Wave by Magnetron

Short communication. 5 refs., 2 figs.

1996-12-31

98

Pulsations in the compression chamber, a potential cause of damage?; Pulsationen im Verdichtungsraum - eine potentielle Schadensursache?

Full Text Available

2008-12-01

99

Incidents of major damage to steam turbines

No abstract prepared.

2005-05-01

100

Estimation of atmospheric source rate of vapors from a damaged container of hazardous chemicals

The author furnishes a review of incidents of major damage to high-output steam turbines. At the same time, he thereby underlines the call for an improvement in the exchange of experience on such damage and its causes at international level. Only the careful observance of past damage experience - including that of foreign manufacturers and operators - complete and modern monitoring equipment and the painstaking evaluation of all data furnished by such equipment can keep the risk of new technical development within economically tolerable limits. (orig.).

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101

Effect of the Toluene Administration on the Liver Damage in Rats Fed Low or Standard Protein Diet

Short communication.

1993-07-01

102

Effect of Cyclohexanone Treatment on the Activities of Oxygen Free Radical Metabolizing Enzyme in the Liver Damaged Rats

Full Text Available

1996-12-01

103

Effect of Cyclohexane Treatment on the Liver Damage in CCl4-Pretreated Rats

Full Text Available

2002-06-01

104

Effect of Cyclohexane Treatment on Serum Level of Glutathione S-Transferase Activity in Liver Damaged Rats

Full Text Available

2003-06-01

105

Comparison of glaucomatous optic nerve damage in primary angle-closure glaucoma with and without acute attack.

Full Text Available

2003-06-01

106

Commentary on: Molecular basis for discriminating between normaland damaged bases by the human alkyladenine glycosylase, AAG

Full Text Available

2005-09-01

107

A Study on the Relationship between the Eccentricity and the Level of Damage in the Seismic Response of Buildings with Plan Irregularities

No abstract prepared.

2001-03-05

108

A Study of the Histological Effects of Garlic Extract in a Liver-damage Rat Model

Full Text Available

2010-06-01

109

Hemodynamic characterization of chronic bile duct-ligated rats: effect of pentobarbital sodium

Full Text Available

2010-08-01

110

Duration-controlled swimming exercise training induces cardiac hypertrophy in mice.

Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an excellent model for hemodynamic investigations but should be ...

111

A comparative evaluation of electrical velocimetry and inert gas rebreathing for the non-invasive assessment of cardiac output

Exercise training associated with robust conditioning can be useful for the study of molecular mechanisms underlying exercise-induced cardiac hypertrophy. A swimming apparatus is described to control training regimens in terms of duration, load, and frequency of exercise. Mice were submitted to 60- vs 90-min session/day, once vs twice a day, with 2 or 4% of the weight of the mouse or no workload attached to the tail, for 4 vs 6 weeks of exercise training. Blood pressure was unchanged in all groups while resting heart rate decreased in the trained groups (8-18%). Skeletal muscle citrate synthase activity, measured spectrophotometrically, increased (45-58%) only as a result of duration and frequency-controlled exercise training, indicating that endurance conditioning was obtained. In groups which received duration and endurance conditioning, cardiac weight (14-25%) and myocyte dimension (13-20%) increased. The best conditioning protocol to ...

2003-11-17

112

British Library Electronic Table of Contents (United Kingdom)

Background When assessing the function of the cardiovascular system, cardiac output (CO) is a substantial parameter. For its determination, numerous non-invasive techniques have been proposed in the recent years including inert gas rebreathing (IGR) and impedance cardiography (ICG). The aim of our study was to evaluate whether a novel ICG algorithm (electrical velocimetry) and IGR can be used interchangeably in the clinical setting. Methods A total of 120 consecutive stable patients were included resulting in two pairs of repeated non-invasive cardiac output measurements. Results The mean CO was 5.0???1.2?l/min (range 2.6?8.6?l/min) using IGR and 4.4???1.1?l/min (1.7?7.4?l/min) using ICG, respectively. Bland?Altman analysis revealed an acceptable agreement with a mean bias of 0.6???1.2?l/m...

2011-01-01

113

The use of combustible metals in explosive incendiary devices

Genotoxic damage in polychaetes: A study of species and cell-type sensitivities

We have investigated tailoring damage effects of explosive devices by addition of unconventional materials, specifically combustible metals. Initial small-scale as well as full-scale testing has been performed. The explosives functioned to disperse and ignite these materials. Incendiary, enhanced-blast, and fragment-damage effect have been identified. These types of effects can be used to extend the damage done to hardened facilities. In other cases it is desirable to disable the target with minimal collateral damage. Use of unconventional materials allows the capability to tailor the damage and effects of explosive devices for these and other applications. Current work includes testing of an incendiary warhead for a penetrator.

1996-08-01

114

British Library Electronic Table of Contents (United Kingdom)

The marine environment is becoming increasingly contaminated by environmental pollutants with the potential to damage DNA, with marine sediments acting as a sink for many of these contaminants. Understanding genotoxic responses in sediment-dwelling marine organisms, such as polychaetes, is therefore of increasing importance. This study is an exploration of species-specific and cell-specific differences in cell sensitivities to DNA-damaging agents in polychaete worms, aimed at increasing fundamental knowledge of their responses to genotoxic damage. The sensitivities of coelomocytes from three polychaetes species of high ecological relevance, i.e. the lugworm Arenicola marina, the harbour ragworm Nereis diversicolor and the king ragworm Nereis virens to genotoxic damage are compared, and dif...

2008-01-01

115

Damage to rotor blades in axial steam turbines

The chance finding of an aneurysm of the right sinus of Valsalva in an 11-year-old child with a ventricular septal defect and a pericardial effusion

A statistical evaluation of rotor blade damage in axial steam turbines affords an insight into the extent of the repair costs incurred and reveals the types of defects and shortcomings which cause such damage. The great amount of rotor blade damage discovered during control inspections will surprise even many turbine experts. The statistical evaluation is followed by a review of the more frequent causes of damage and their characteristic features, illustrated on the basis of practical examples. This contribution is intended as an aid to both the manufacturers and operators of steam turbines in preventing the oft almost classic types of faults which constantly recur. (orig.).

116

British Library Electronic Table of Contents (United Kingdom)

Ventricular septal defects can occur as part of other congenital cardiac malformations or as an isolated finding. Aneurysms of the sinus of Valsalva are rare, most commonly involving the right or noncoronary sinuses. They can be congenital or acquired through infection, trauma, or degenerative diseases. They frequently co-exist with ventricular septal defects, aortic valve dysfunction, or other cardiac abnormalities. More commonly, sinus of Valsalva aneurysms are diagnosed after the clinical sequelae of rupture. Several etiologic factors may lead to the development of pathologic pericardial effusion and the detection of pericardial effusion was one of the first applications of echocardiography to gain widespread acceptance. We present a case of a chance finding of an aneurysm of the right ...

2011-01-01

117

Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure

British Library Electronic Table of Contents (United Kingdom)

Hsp20, referred to as HspB6, is constitutively expressed in various tissues. Specifically, HspB6 is most highly expressed in different types of muscle including vascular, airway, colonic, bladder, and uterine smooth muscle; cardiac muscle; and skeletal muscle. It can be phosphorylated at Ser-16 by both cAMP- and cGMP-dependent protein kinases (PKA/PKG). Recently, Hsp20 and its phosphorylation have been implicated in multiple physiological and pathophysiological processes including smooth muscle relaxation, platelet aggregation, exercise training, myocardial infarction, atherosclerosis, insulin resistance and Alzheimer's disease. In the heart, key advances have been made in elucidating the significance of Hsp20 in contractile function and cardioprotection over the last decade. This mini-rev...

2011-01-01

118

Safety, Efficacy, and Performance of Implanted Recycled Cardiac Rhythm Management (CRM) Devices in Underprivileged Patients

British Library Electronic Table of Contents (United Kingdom)

Introduction: Patients in underdeveloped nations have limited access to life-saving medical technology including cardiac rhythm management (CRM) devices. We evaluated alternative means to provide such technology to this patient population while assessing the safety and efficacy of such a practice. Methods: Patients in the United States with clinical indications for extraction of CRM devices were consented. Antemortem CRM devices were cleaned and sterilized following a protocol established at our institution. Surveillance in vitro cultures were performed for quality assurance. The functional status of pulse generators was tested with a pacing system analyzer to confirm at least 70% battery life. Most generators were transported, in person, to an implanting institution in Nicaragua. Recipien...

2011-01-01

119

RIFLE Criteria for Cardiac Surgery-Associated Acute Kidney Injury: Risk Factors and Outcomes

British Library Electronic Table of Contents (United Kingdom)

The aims of this study were to identify risk factors and evaluate the association with clinical outcomes of postoperative cardiac surgery-associated acute kidney injury (CSA-AKI). Data from 2488 consecutive adult patients were analyzed. Patients were classified as having CSA-AKI based on the risk, injury, failure, loss of kidney function, and end-stage kidney disease (RIFLE) criteria using peak postoperative creatinine in the postoperative intensive care unit (ICU). Multiple stepwise logistic regression analysis was used to identify independent risk factors for CSA-AKI. CSA-AKI occurred in 584 patients (23.5%). CSA-AKI patients had significantly longer aortic cross-clamp and cardiopulmonary bypass times. Furthermore, CSA-AKI patients had higher hospital mortality (5.5% vs 1.5%, PCopyright2...

2010-01-01

120

PET and MRI in cardiac imaging: from validation studies to integrated applications

Extraction of Cs-137 by alcohol-water solvents from plants containing cardiac glycosides

Positron emission tomography (PET) is the gold standard for non-invasive assessment of myocardial viability and allows accurate detection of coronary artery disease by assessment of myocardial perfusion. Magnetic resonance imaging (MRI) provides high resolution anatomical images that allow accurate evaluation of ventricular structure and function together with detection of myocardial infarction. Potential hybrid PET/MR tomography may potentially facilitate the combination of information from these imaging modalities in cardiology. Furthermore, the combination of anatomical MRI images with the high sensitivity of PET for detecting molecular targets may extent the application of these modalities to the characterization of atherosclerotic plaques and to the evaluation of angiogenetic or stem cell therapies, for example. This article reviews studies using MRI and PET in parallel to compare their performance in cardiac applications together with the potential benefits ...

2009-03-01

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121

Drug detection in breath: effects of pulmonary blood flow and cardiac output on propofol exhalation

As a result of nuclear power plant accidents, large areas receive radioactive inputs of Cs-137. This cesium accumulates in herbs growing in such territories. The problem is whether the herbs contaminated by radiocesium may be used as a raw material for medicine. The answer depends on the amount of Cs-137 transfered from the contaminated raw material to the medicine. We have presented new results of the transfer of Cs-137 from contaminated Digitalis grandiflora Mill. and Convallaria majalis L. to medicine. We found that the extraction of Cs-137 depends strongly on the hydrophilicity of the solvent. For example 96.5%(vol.) ethyl alcohol extracts less Cs-137 (11.6%) than 40%(vol.) ethyl alcohol or pure water (66.2%). The solubility of the cardiac glycosides is inverse to the solubility of cesium, which may be of use in the technological processes for manufacturing ecologically pure herbal medicine.

2001-01-01

122

British Library Electronic Table of Contents (United Kingdom)

Breath analysis could offer a non-invasive means of intravenous drug monitoring if robust correlations between drug concentrations in breath and blood can be established. In this study, propofol blood and breath concentrations were determined in an animal model under varying physiological conditions. Propofol concentrations in breath were determined by means of two independently calibrated analytical methods: continuous, real-time proton transfer reaction mass spectrometry (PTR-MS) and discontinuous solid-phase micro-extraction coupled with gas chromatography mass spectrometry (SPME-GC-MS). Blood concentrations were determined by means of SPME-GC-MS. Effects of changes in pulmonary blood flow resulting in a decreased cardiac output (CO) and effects of dobutamine administration resulting in...

2011-01-01

123

Chronic sympathetic activation promotes downregulation of ?-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction

British Library Electronic Table of Contents (United Kingdom)

It is uncertain if downregulation of ?-adrenoceptor signaling pathway is promoted by an enhanced adrenergic tone at an early stage of cardiac disease, or it develops secondary to detrimental local myocardial changes in advanced heart failure. We examined the integrity of ?-adrenoceptor signaling pathway upon chronic infusion of isoproterenol, a ?-adrenoceptor agonist, at a dose producing no structural left ventricular (LV) remodeling and systolic dysfunction. Subcutaneous isoproterenol infusion (400??g?kg?1?h?1 over 16?days) to guinea pigs using osmotic minipumps produced no change in cardiac weights, LV internal dimensions, myocyte cross-sectional area, extent of interstitial fibrosis, and basal contractile function. Isolated, perfused heart preparations from isoproterenol-treated guinea ...

2011-01-01

124

Challenges in presenting high dimensional data to aid in triage in the DARPA virtual soldier project.

Cardiac transplantation. Value of computed tomography

One of the goals of the DARPA Virtual Soldier Project is to aid the field medic in the triage of a casualty. In Phase I, we are currently collecting 12 baseline experimental physiological variables and a cardiac gated Computed Tomography (CT) imagery for use in an prototyping a futuristic electronic medical record, the "Holomer". We are using physiological models and Kalman filtering to aid in diagnosis and predict outcomes in relation to cardiac injury. The physiological modeling introduces another few hundred variables. Reducing the complexity of the above into easy-to-read text to aid in the triage by the field medic is the challenge with multiple display solutions. A description of the possible techniques follows. PMID:15718701

2005-01-01

125

Cardiac Pacing: Memories of a Bygone Era

In 9 over 12 patients who underwent cardiac transplantation computed tomography was performed. In 5 of them CT was obtained also before the surgical treatment. In all patients angio-CT technique was performed, while the ECG-gated technique was employed only before surgery. CT shows changes in morphology of both atria but over all of the right one, and rotation of the heart on the longitudinal axis. The conditions of the pericardium are particulary well demonstrated: in 5 cases pericardial effusion was observed, 3 times localized and 2 times diffuse. Only in 1 patient a small thrombus in the right atrium was demonstrated. CT allows the possibility to obtain simultaneously information on mediastinum, lung and pleura. Pleural effusion, pulmonary infections and mediastinal complications are easily demonstrated.

1986-01-01

126

British Library Electronic Table of Contents (United Kingdom)

The first cardiac pacemaker implants occurred in the late 1950s and involved insertion of epicardial or epimyocardial leads and abdominal pulse generators. By the mid 1960s, cardiologists were making attempts to insert transvenous leads into the right ventricle. These early unipolar leads had large, polished, high polarization electrodes, no fixation device, and no lumen in which to place a stylet for lead positioning. The lead implantation procedures were usually long and the irradiation to both patient and operator excessive. Pulse generators were powered by zinc-mercury cells, which were large, unreliable, and prone to sudden output failure. Postoperative complications such as lead dislodgement, exit block, and premature power source failure were very common with most patients requiring...

2008-01-01

127

Alumnium phosphide fatalities at mild exertion in asymptomatic children: A clue to understand the variations of the autopsy findings

British Library Electronic Table of Contents (United Kingdom)

Fatalities resulted from aluminium phosphide (ALP) intoxication in completely healthy children with no preceded clinical sings or symptoms were presented. Data regarding circumstances, autopsy reports, histopathological examination, toxicological investigation, and police enquiries were also collected and evaluated. The affected children were females, and 6-16 years old. They were completely healthy and died suddenly in relation to some physical activities such as running, walking, and bathing, without any prior complain. The viscera showed intense congestion with moderate to severe pulmonary edema. The cause of the sudden termination of life in the reported cases is mostly cardiac ones. Physical exertion may precipitate death due to increased cardiac stress, increased oxygen demand, and b...

2009-01-01

128

A patient specific electro-mechanical model of the heart

British Library Electronic Table of Contents (United Kingdom)

This paper presents a patient specific deformable heart model that involves the known electrical and mechanical properties of the cardiac cells and tissue. The whole heart model comprises ten Tusscher's ventricular and Nygren's atrial cell models, the anatomical and electrophysiological model descriptions of the atria (introduced by Harrild et al.) and ventricle (given by Winslow et al.), and the mechanical model of the periodical cardiac contraction and resting phenomena proposed by Moireau et al. During the propagation of the depolarization wave, the kinetic, compositional and rotational anisotropy is handled by the tissue, organ and torso model. The applied patient specific parameters were determined by an evolutionary computation method. An intensive parameter reduction was performed u...

2011-01-01

129

Mechanism of the accumulation effect in laser damage to polymers: appearance of microdamage due to an ionization absorption wave

[Heart injuries: diagnosis and therapy].

An investigation was made of the accumulation of laser damage to transparent polymers irradiated with nanosecond pulses from neodymium and ruby lasers. The damage was investigated by the method of scattering and luminescence in the visible and near ultraviolet parts of the spectrum. It was established that there were two stages in laser damage by repeated irradiation with pulses of intensity below the single-shot damage threshold. An absorbing defect evolved during the first stage in such a way as to create a thermal instability in the surrounding matrix. During the second stage this thermal instability caused spatial growth of laser damage because of propagation of an ionization-inducing absorption wave with a front traveling at the rate governed by the electron component of the thermal conductivity.

1984-04-01

130

The Significance of Clopidogrel Low-Responsiveness on Stent Thrombosis and Cardiac Death Assessed by the Verifynow P₂Y₁₂ Assay in Patients With Acute Coronary Syndrome Within 6 Months After Drug-Eluting Stent Implantation

The clinical manifestation of wounds of the heart is determined by the mode, site and size of the injury as well as the structure of the pericardial and myocardial lesion. Diagnosis can be confirmed by ECG and echocardiography. Only 20% of the patients with penetrating wounds of the heart live for more than 30 minutes. Pericardio-centesis should be used only to gain time for a safe sternotomy, cardiac decompression and suture of the wound of the heart. An aggressive surgical approach is mandatory. Cardiopulmonary bypass is necessary only to correct of concomitant lesions. PMID:1983618

1990-01-01

131

Telemetry system for monitoring the ECG for patients with high cardiovascular risk. Main design requirements and technical solutions

Background and ObjectivesClopidogrel resistance or low-responsiveness may be associated with recurrent atherothrombotic events after drug-eluting stent (DES) implantation. We prospectively...Full Text Available

2009-12-01

132

Photolysis of the novel inotropes EMD 57033 and EMD 57439: evidence that Ca2+ sensitization and phosphodiesterase inhibition depend upon the same enantiomeric site.

In this paper the main design requirements concerning the setting up of a telemetry ECG monitoring system are presented. The design's most important technical solutions as well as some details are also discussed. This system is intended to provide skilled medical assistance during the cardiac rehabilitation of both asymptomatic and high risk coronary patients

2005-01-01

133

Phospholamban and its Phosphorylated Form Interact Differently with Lipid Bilayers: A ³¹P, ²H and ¹³C Solid-State NMR Spectroscopic Study

1. We studied the effects of flash photolysis on the novel enantiomeric cardiac inotropes EMD 57033 (a calcium sensitizer) and EMD 57439 (a phosphodiesterase III inhibitor) in rat isolated ventricular...Full Text Available

1996-08-01

134

Pericardio-peritoneal drainage using a subcostal approach.

Phospholamban (PLB) is a 52-amino acid integral membrane protein that helps to regulate the flow of Ca²⁺ ions in cardiac muscle cells. Recent structural studies on the PLB pentamer...Full Text Available

2006-11-07

135

Lyme myocarditis diagnosed by indium-111-antimyosin antibody scintigraphy

A 56-year-old man admitted to our hospital for cardiac tamponade due to dilated cardiomyopathy did not respond to treatment by usual medical means or surgery. Pericardio-peritoneal drainage was conducted using a subcostal approach. Seven months later, the patient remains well and free of signs of pericardial tamponade. This method has proved to be safe and effective in patients with persistent massive pericardial effusion. PMID:10496067

1999-08-01

136

Long- but not short-term heat acclimation produces an apoptosis-resistant cardiac phenotype: a lesson from heat stress and ischemic/reperfusion insults

We report a new case of Lyme disease with cardiac manifestations, which has been possible to follow during the long period of 12 years. We have detected the usual ECG abnormalities, and concentric hypertrophic myocardiopathy, by echocardiography. The acute myocarditis was demonstrated by /sup 111/In-antimyosin scintigraphy, which showed global myocardial uptake of the tracer, constituting the first report, to our knowledge, of Lyme myocarditis diagnosed by this method.

1989-06-01

137

Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy(SUDEP)

Long-term heat acclimation (AC, 30d/34°C) is a phenotypic adaptation leading to increased thermotolerance during heat stress (HS, 2 h 41°C). AC also renders protection against...Full Text Available

2010-09-01

138

Homocysteine effects classical pathway of GPCR down regulation: G?_q/11, G?_12/13, G_i/o

Mice lacking Kv1.1 Shaker-like potassium channels encoded by the Kcna1 gene exhibit severe seizures and die prematurely. The channel is widely expressed in...Full Text Available

2010-04-14

139

Fatal left cardiac failure caused by external compression of left internal mammary artery graft in an accident: a case report

G protein-coupled receptors (GPCRs) are known to modulate intracellular effectors involved in cardiac function. We recently reported homocysteine (Hcy)-induced ERK-phosphorylation was suppressed...Full Text Available

2009-01-01

140

Detection of acute myocardial infarction in spontaneously hypertensive rats by /sup 99m/Tc-Pyrrolidino methyl tetracycline

We report for the first time a case of a 54 years old man with a fatal motorcycle accident due to an external bleeding compression of left internal mammary artery graft to the left anterior descending...Full Text Available

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141

Corrected transposition of the great arteries

The myocardial infarct induced by isoproterenol in spontaneously hypertensive rats accumulates higher activities of /sup 99/sup(m)Tc-PM tetracycline compared with the cardiac infarct in normotensive rats caused by the same method. The isoproterenol model of the myocardial necrosis was induced in intact rats without opening the thorax and is a convenient method for experimental radioisotope studies.

1983-01-01

142

Computed tomography - old ideas and new technology

The corrected transposition of the great arteries is an usual congenital cardiac malformation, which consists of transposition of great arteries and ventricular inversion, and which is caused by abnormal development of conotruncus and ventricular looping. High frequency of associated cardiac malformations makes it difficult to get accurate morphologic diagnosis. A total of 18 cases of corrected transposition of the great arteries is presented, in which cardiac catheterization and angiocardiography were done at the Department of Radiology, Seoul National University Hospital between September 1976 and June 1981. The clinical, radiographic, and operative findings with the emphasis on the angiocardiographic findings were analyzed. The results are as follows: 1. Among 18 cases, 13 cases have normal cardiac position, 2 cases have dextrocardia with situs solitus, 2 cases have dextrocardia with situs inversus ...

1981-12-01

143

Blood EPA and DHA Independently Predict All-Cause Mortality in Patients with Stable Coronary Heart Disease. The Heart and Soul Study

Several recently introduced 'new' techniques in computed tomography - iterative reconstruction, gated cardiac CT, multiple-source, and dual-energy CT - actually date back to the early days of CT. We review the historic origins and evolution of these techniques, which may provide some insight into the latest innovations in commercial CT systems. (orig.)

2011-03-01

144

The interpolation damage detection method for frames under seismic excitation

BackgroundOmega-3 fatty acid (n-3 FA) blood levels and intakes have been inversely associated with risk for sudden cardiac death, but their relationship with all-cause...Full Text Available

2010-07-01

145

Effect of chlordecone (kepone) on calcium transport mechanisms in rat heart sarcoplasmic reticulum

In this paper a new procedure, addressed as Interpolation Damage Detecting Method (IDDM), is investigated as a possible mean for early detection and location of light damage in a structure struck by an earthquake. Damage is defined in terms of the accuracy of a spline function in interpolating the operational mode shapes (ODS) of the structure. At a certain location a decrease (statistically meaningful) of accuracy, with respect to a reference configuration, points out a localized variation of the operational shapes thus revealing the existence of damage. In this paper, the proposed method is applied to a numerical model of a multistory frame, simulating a damaged condition through a reduction of the story stiffness. Several damage scenarios have been considered and the results indicate the effectiveness of the method to assess and localize ...

2011-10-01

146

Whey protein isolate attenuates strength decline after eccentrically-induced muscle damage in healthy individuals

Since chlordecone (Kepone, CD) interferes with cardiac Na{sup +} ion translocases, we have studied CD effects on cardiac SR calcium pump activity. SR was isolated from heart ventricles of male Sprague-Dawley rats. Cardiac SR Ca{sup 2+}-ATPase, {sup 45}Ca-uptake and cAMP as well as calmodulin (CaM) dependent protein phosphorylation were measured. Ca{sup 2+}-ATPase was differentiated into low affinity and high affinity forms by measuring the activity using 50 and 0.7 {mu}M free Ca{sup 2+} respectively. CD in vitro inhibited {sup 45}Ca-uptake by SR in a concentration dependent manner with an IC50 value of 7 {mu}M and SR {sup 45}Ca-uptake was totally inhibited at 20-30 {mu}M CD. In agreement with this, both high affinity and low affinity Ca{sup 2+}-ATPases, which are involved in Ca{sup 2+} transport across membranes, were also inhibited by CD in a concentration dependent manner with IC50 values of 0.7 and 3.2 {mu}M ...

1990-01-01

147

The construction of earthquake damage estimation system for city gas supply system

BackgroundWe examined the effects of short-term consumption of whey protein isolate on muscle proteins and force recovery after eccentrically-induced muscle damage in healthy individuals.MethodsSeventeen...Full Text Available

148

NOAA Fisheries Office of Exxon Valdez Oil Spill (EVOS) Damage...

The regular occurrence of large-scale earthquakes in Japan necessitates the use of earthquake disaster prevention systems that focus on gathering damage information on gas supply facilities immediately after an earthquake strikes and minimizing the damage. This paper discussed the development of an earthquake damage estimation system for city gas pipelines that can show damage information in real-time by using earthquake records obtained from densely deployed earthquake observation networks and the most advanced telecommunication and information technologies. The paper summarized the earthquake damage estimation system (EDES) and Toho Gas disaster prevention measures. Specific topics that were discussed included the Toho Gas supply method; earthquake countermeasures; construction of computer systems; normal and emergency operation of EDES; and verification of functions in actual ...

2010-07-01

149

Intracellular Copper Does Not Catalyze the Formation of Oxidative DNA Damage in Escherichia coli?

Service, Alaska Regional Office Prince William Sound, photo: Mandy Lindeberg Office of Exxon Valdez Oil Spill (EVOS) Damage Assessment and Restoration About NOAA Fisheries' EVOS...

2011-08-20

150

Does Damage to DNA and Other Macromolecules Play a Role in Aging? If So, How?

Because copper catalyzes the conversion of H₂O₂ to hydroxyl radicals in vitro, it has been proposed that oxidative DNA damage may be an important component of copper toxicity....Full Text Available

2007-03-01

151

Cement-based composites: Strain rate effects on fracture

One of the most pervasive ideas regarding the causes of aging is that longevity is constrained in large measure by damage to macromolecules. An increasing body of cellular and molecular data, generated...Full Text Available

2009-02-01

152

Cellular Senescence, Radiation Damage to Mitochondria, and the Compensatory Response in Ripening Pear Fruits ¹

This book contains over 20 selections. Some of the titles are: Continuum damage mechanics studies on the dynamic fracture of concrete; Dynamic compressive strength of cementitious materials; Rate-sensitivity of mode I and mode II fracture concrete; and An impact damage model of concrete.

1986-01-01

153

Annealing behavior of radiation damages in metal-silicides

A compensatory response, viz. in vivo recovery from radiation damage to mitochondria, occurs in preclimacteric pear fruits (Pyrus communis L.) treated with ionizing...Full Text Available

1968-07-01

154

A novel enzyme-based acidizing system: Matrix acidizing and drilling fluid damage removal

The annealing behavior of the radiation damage in epitaxial Pd_2Si and NiSi_2 films on Si, due to the implantation of 100 keV Ar ions, is investigated by using the channeling technique with "4He ions. (U.K.).

155

Water chemistry for mitigation of the corrosion damage of reactor structural materials

A novel acidizing process is used to increase the permeability of carbonate rock cores in the laboratory and to remove drilling fluid damage from cores and wafers. Field results show the benefits of the technology as applied both to injector and producer wells.

1995-12-31

156

Three-dimensional damage distributions in ion-irradiated silicon and pyrolytic graphite as revealed by modified tomography in combination with RBS and NDP

... 1343-3563 v. 57(1) SPECIFIC NUCLEAR REACTORS AND ASSOCIATED

2011-01-01

157

Residual Seismic Capacity Evaluation of RC Frames with URM Infill Wall Based on Residual Crack Width and Damage Class

Short communication.

1995-12-31

158

RAPID DAMAGE ASSESSMENT FROM HIGH RESOLUTION IMAGERY

Full Text Available

2009-10-01

159

Protective Effect of an Ethanol Extract Mixture of Curcuma longae Radix, Phellinus linteus, and Scutellariae Radix on Oxidative Neuronal Damage

Disaster impact modeling and analysis uses huge volumes of image data that are produced immediately following a natural or an anthropogenic disaster event. Rapid damage assessment is the key to time critical decision support in disaster management to better utilize available response resources and accelerate recovery and relief efforts. But exploiting huge volumes of high resolution image data for identifying damaged areas with robust consistency in near real time is a challenging task. In this paper, we present an automated image analysis technique to identify areas of structural damage from high resolution optical satellite data using features based on image content.

2008-07-01

160

Long-term hygrothermal effects on damage tolerance of hybrid composite sandwich panels

Full Text Available

2011-02-01

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161

Damage mechanism in high temperature fatigue of alloy 800 H

A sandwich construction, composed of hybrid carbon-glass fiber-reinforced plastic skins and a

1995-01-01

162

Damage characteristics of time domain histories

In order to investigate the influence of grain boundary cavities on the life time of Alloy 800 H various fatigue tests have been performed at 800/sup 0/C. Cavity formation has been observed only in asymmetrical tests. Compared to the corresponding symmetrical tests, the cyclic life time is shorter. As the cavitation damage increases, the ratio of life times in vacuum and in air steadily decreases from an initial value of 5. In extreme cases it can reach a value close to 1. In this case, cavitation damage dominates over the usual damage mechanism, which is cracks from the surface.

1986-09-01

163

Damage and Repair of the APS Graphite/Epoxy Composite ...

It is possible to create nomographs similar to Fig. 2.10 to characterise damage potential of candidate time histories, provided there exists extensive records of earlier time-histories and the damage that they have caused. Thus in order to create such nomographs, one needs the correlated documentation between the input to the structure and the resulting damage. In order to use the Response-Spectra approach, one needs good statistical description of the input to the system. Extensive literature exists on both these methods. The MAC method that has being developed for the present research has yet to be validated. However, if it is successful, it would provide a valuable link between the SEA method and the rational method.

1989-11-01

164

Chromosomal damage in human lymphocytes from radio-isotope therapy

... Abstract : High temperature testing of graphite/epoxy laminates and composite sandwich panels was performed while the Shuttle was on orbit to ...

1982-10-12

165

An Evaluation of the Severity of the January 1998 Ice Storm in ...

(Dec 1973). United Kingdom Stevenson, AC Medical Research Council, Oxford

166

A spatial damage energy distribution calculation for ion-implanted materials

... storm. There was little damage to high-voltage transmission lines and communication towers in northern New England. ...

1998-04-01

167

Four cases of bowel perforation following radiation therapy for cervical cancer

A simple method allowing easy calculation of the spatial damage energy distributions for ion-implanted materials is presented. The direct procedure takes account of the variation with depth of the lateral spreading of implanted ions, as well as the effects of energy transport by the recoiling target atoms. The subsequent computer program LUPIN-3D provides three-dimensional damage distributions and allows the construction of damage energy mappings. Various substrates of technological interest are investigated and several fields of application of the calculation are envisaged. The density of cascades can therefore be determined and heterogeneous amorphization models can be implemented. (orig.).

1989-01-01

168

Automated analysis of damages for radiation in plastics surfaces; Analisis automatizado de danos por radiacion en superficies plasticas

External radiation dose exceeded 5,000 rad in three cases, and intravaginal radiation dose was 5,000 rad in one case. Radiation damage including perforation was seen in the end of ileus in one case, in the sigmoid and rectum in two cases, and in the end of ileus, sigmoid and rectum in the last case. Satisfactory results were obtained by the removal of the ileocecum in the case of the damage in the end of the ileus. However, only colostomy was performed for the damage in the sigmoid and rectum.

1984-10-01

169

Vibration testing of the I-40 bridge before and after the introduction of damage

Analysis of damages done by the radiation in a polymer characterized by optic properties of polished surfaces, of uniformity and chemical resistance that the acrylic; resistant until the 150 centigrade grades of temperature, and with an approximate weight of half of the glass. An objective of this work is the development of a method that analyze in automated form the superficial damages induced by radiation in plastic materials means an images analyst. (Author)

1990-02-15

170

Radiation damage in A-15 materials: EXAFS studies

Because the bridges over the Rio Grande were to be razed, the investigators were able to introduce simulated cracks in four stages of increasing length into the structure. This paper summarizes the results of ambient and conventional, measured-input, modal analyses, performed on the undamaged structure. Also summarized are the results of conventional modal analyses performed after each stage of damage had been introduced. These tests were intended to quantify the amount of damage necessary to produce changes in the global dynamic properties of the bridge and to form a data base that can be used by other investigators to develop damage identification algorithms. Conventional modal analysis identified changes in the global dynamic properties of the structure only after the final stage of a damage.

1994-11-01

171

Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain

EXAFS measurements are useful in determining the local atomic environment of a particular element in a solid. Since there has been some controversy about the nature of the defects produced in A-15 materials by radiation damage, such studies were carried out on some A-15 compounds, V_3Ga which was damaged by neutrons, as well as Nb_3Ge damaged by 2.5 MeV a particles. In the V_3Ga sample, site exchange disorder seems to be the most important result of the neutron damage with less than 20% of the vanadium atoms on wrong sites. However, in the Nb_3Ge samples in addition to site exchange disorder, an unusual splitting of the first near-neighbor distance between the Ge and Nb is found. This splitting, approximately 0.2 A, may explain the large Debye Waller factors observed by Burbank et al.

172

British Library Electronic Table of Contents (United Kingdom)

Summary Status epilepticus or other brain-damaging insults launch a cascade of events that may lead to the development of epilepsy. MRI techniques available today, including T2- and T1-weighted imaging, functional MRI, manganese enhanced MRI (MEMRI), arterial spin labeling (ASL), diffusion tensor imaging (DTI), and phase imaging, can detect not only damage caused by status epilepticus but also plastic changes in the brain that occur in response to damage. Optimal balance between damage and recovery processes is a key for planning possible treatments, and noninvasive imaging has the potential to greatly facilitate this process and to make personalized treatment plans possible.

2011-01-01

173

Fission neutron damage rates and efficiencies in several metals

Advanced experimental design applied to damage tolerance of composite materials

Initial rates of resistivity-measured low-temperature damage production by fission-spectrum fast neutrons have been determined for 14 metals in the same very well characterized irradiation facility. Six of these metals were fcc, 5 bcc, and 3 hcp. Most were of quite high purity. Observed damage rates, after correction for all known extraneous resistivity-producing effects, were compared with rates predicted by the damage calculation code RECOIL, using parameters chosen from the literature. These parameters, effective displacement threshold energy, E/sub d/, and Frenkel-pair resistivity, rho/sub F/, were in many cases only best estimates, the further refinement of which may be aided by the present results. Damage efficiencies (measured/predicted rates) follow the same trends by crystal classes as seen in other fast-neutron studies.

2003-04-01

174

Early detection of damage and analysis of damage development in metal structural components. Schaedigungsfrueherkennung und Schadensablauf bei metallischen Bauteilen

This paper focuses on a factorial-based design strategy. The approach provides an efficient and statistically reliable means for assessing the influence of multivariable effects. It is applied to the detection and evaluation of damage in impacted composite sandwich panels. The experimental results obtained from this test strategy are utilized to form an empirical response function. The resulting polynomial relates damage area to residual compression strength at values of independent variables for which testing did not occur. The response function also identifies nonlinear interaction effects of key variabes that cannot be easily ascertained by traditional single-variable test strategies. Independent variables evaluated include core thickness, number of face sheet plys and impact energy. The methodology presented allows the designer to predict with more confidence the damage tolerance of a composite material component, and ...

1991-01-01

175

DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle

The topics of these short lectures on the subject of cyclic stress were: Microstructural mechanisms of damage accumulation under a multistage cyclic stress until incipient cracking; influence of surface decarbonizing phenomena on the failure behaviour of steel construction parts subjected to cyclic stress; thermocyclic fatigue of pipe samples of austenitic steel 1.4436; studies on surface structuring, microstructure and fatigue in LCF area. The short lectures on effects of quasi-static and creep stress were: Shear fracture in AlMg alloys as a result of local plastic instability; study of formation and growth of pores for an early recognition of damage and the course of damage in heat-resistant steels under creep test; experimental and numeric studies of the infuence of the microstructure on the course of damage during shear fractures of steel; numerical modelling of ductile fractures on the basis of ...

1989-01-01

176

Fundamentals for remote structural health monitoring of wind turbine blades - a pre-project. Annex D - Full-scale test of wind turbine blade, using sensors and NDT

The DNA double-strand break (DSB) damage response induced by high energy charged particles on lung fibroblast cells embedded in a 3-dimensional (3-D) collagen tissue equivalents was investigated using antibodies to the DNA damage response proteins gamma-histone 2AX (#gamma#-H2AX) and phosphorylated DNA-PKcs (p-DNA-PKcs). 3-D tissue equivalents were irradiated in positions across the linear distribution of the Bragg curve profiles of 307.7 MeV/nucleon, 556.9 MeV/nucleon, or 967.0 MeV/nucleon "5"6Fe ions at a dose of 0.30 Gy. Patterns of discrete DNA damage streaks across nuclei or saturated nuclear damage were observed, with saturated nuclear damage being more predominant as samples were positioned closer to the physical Bragg peak. Quantification of the DNA damage signal intensities at each distance for each of the examined energies revealed a biological Bragg ...

2010-03-01

177

A detailed physical model for ion implant induced damage in silicon

A 19.1 metre wind turbine blade was subjected to static tests. The purpose of the test series was to verify the abilities of different types of sensors to detect damage in wind turbine blades. Prior to each of the static test-series an artificial damage was made on the blade. The damage made for each test-series was surveyed during each series by acoustic emission, fiber optic micro bend displacement transducers and strain gauges. The propagation of the damage was determined by use of ultra sonic and X-ray surveillance during stops in the test series. By use of acoustic emission it was possible to measure damage propagation before the propagation was of visible size. By use of fiber optic micro bend displacement transducers and strain gauges it was possible to measure minor damage propagation. By use of both ultra sonic, and X-ray NDT-equipment it were possible ...

2002-05-01

178

A detailed physical model for ion implant induced damage in silicon

A unified physically based ion implantation damage model has been developed which successfully predicts both the impurity profiles and the damage profiles for a wide range of implant conditions for arsenic, phosphorus, BF{sub 2}, and boron implants into single-crystal silicon. In addition, the amorphous layer thicknesses predicted by this new damage model are also in excellent agreement with experimental measurements. This damage model is based on the physics of point defects in silicon, and explicitly simulates the defect production, diffusion, and their interactions which include interstitial-vacancy recombination, clustering of same type of defects, defect-impurity complex formation, emission of mobile defects from clusters, and surface effects for the first time. New computationally efficient algorithms have been developed to overcome the barrier of the excessive computational requirements. In ...

1998-06-01

179

Subcellular distribution of ryanodine receptors in the cardiac muscle of carp (Cyprinus carpio).

A unified physically based ion implantation damage model has been developed which successfully predicts both the impurity profiles and the damage profiles for a wide range of implant conditions for arsenic, phosphorus, BF_2, and boron implants into single-crystal silicon. In addition, the amorphous layer thicknesses predicted by this new damage model are also in excellent agreement with experimental measurements. This damage model is based on the physics of point defects in silicon, and explicitly simulates the defect production, diffusion, and their interactions which include interstitial-vacancy recombination, clustering of same type of defects, defect-impurity complex formation, emission of mobile defects from clusters, and surface effects for the first time. New computationally efficient algorithms have been developed to overcome the barrier of the excessive computational requirements. In addition, ...

1998-06-01

180

Radiocardiographic measurement of minimum central transit times by means of indium-113m-DTPA and of a 8-crystal radiocardiograph (Gamma Retina VI)

We examined the subcellular localization of ryanodine receptors (RyR) in the cardiac muscle of carp using biochemical, immunohistochemical, and electron microscopic methods and compared it with those of rats and guinea pigs. To achieve this goal, an anti-RyR antibody was newly raised against a synthetic peptide corresponding to an amino acid sequence that was conserved among all sequenced RyRs. Western blot analysis using this antibody detected a single RyR band following the SDS-PAGE of sarcoplasmic reticulum (SR) membranes from carp atrium and ventricle as well as from mammalian hearts and skeletal muscles. The carp heart band had slightly greater mobility than those of mammalian hearts. Although immunohistochemical staining showed evident striations corresponding to the Z lines in longitudinal sections of mammalian hearts, clusters of punctate staining, in contrast, were distributed ubiquitously throughout carp atrium and ventricle. Electron microscopic images ...

2003-06-12

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181

Quantification of the local glucose utilization and local blood flow in the heart of the awake rat using the /sup 14/C-2-deoxyglucose and /sup 14/C-iodoantipyrine methods

The minimum cardiac transit times (MTT's) at rest and following sub-maximum stresses were measured in 97 individual examinations of untrained persons and high performance athletes. It turned out that there is a strong dependence on cardiac frequency of the MTT's. This relation can be described quite satisfactorily by a hyperbolic function and in this way allows a frequency correction to be made of the MTT's. The MTT's standardized in this way (MTT.f values) represent the quotient of the end diastolic segment volume/beat volume. In the whole lesser circulatory system almost identical MTT.f values were found for the two groups under comparison at rest and following stress. In the ventricles, however, and especially so in the left ventricle, the MTT.f values were clearly higher with athletes than with untrained persons, but they strongly decreased after stresses, while the respective values remained almost constant in ordinary persons. (orig./RF).

182

Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130

Local cardiac glucose utilization (LCarGU) was quantified in the rat heart according to the Sokoloff model and local cardiac blood flow (LCarBF) according to the /sup 14/C-iodoantipyrine method. For quantitative autoradiography calibration curves for heart slices were performed. They differed from the brain calibration curves by 8%. The lumped constant was 0.377 in isolated working hearts. LCarGU and LCarBF could then be quantified in awake rats. At different locations mean LCarGU of different hearts varied from 85 to 200 ..mu..moles/100g/min and mean LCarBF from 390 to 831 ml/100g/min. The ratio subendocardial/subepicardial glucose utilization or blood flow was not systematically different from 1. The results indicate that glucose can be an important fuel in the heart of the awake rat, although its contribution to overall metabolism varies from animal to animal.

1986-03-05

183

Benzyl carbamyl analogue of lignocaine: vasodepressor mechanism of action.

The chicken extracellular matrix glycoprotein ES/130 is necessary for epithelial-mesenchymal transformation in the developing hear and is also expressed in noncardiac chicken tissues such as limb and notochord. We have identified hES, the human homology of chicken ES/130. Fluorescence in situ hybridization analysis (FISH) localizes hES to human chromosome 20p11.2-p12. FISH analyses of individuals with 20p12 deletions and affected by Alagille syndrome exclude hES as a candidate gene for this disorder. Reverse transcriptase-polymerase chain reaction studies reveal that hES is expressed in both fetal and adult human tissues and that hES expression in the left ventricle is increased in the failing adult heart. Further studies will evaluate how hES mutations may relate to congenital human cardiac and skeletal anomalies as well as cardiac remodeling in the adult. 16 refs., 2 figs.

1996-08-01

184

Visualization of right atrial appendix by Thallium-201 myocardial scintigraphy: concise communication

1. The benzyl carbamyl analogue of lignocaine [2-(diethylaminoacetamido)-3-carbamyl-4-methyl-5-benzylpyrrole] at an intravenous dose of 4 mg/kg caused a blood pressure decrease of 54 mmHg. 2. A greater hypotensive effect was observed in hypertensive compared to normotensive animals. Anaesthesia magnified the vasodepressor effect in both groups. 3. The analogue did not possess centrally-mediated effects on blood pressure but exerted its hypotensive effect via a peripheral mechanism. 4. The analogue produced a relaxant effect on intestinal and vascular smooth muscle while exerting minimal effects on muscarinic, sympathetic, or ganglionic nicotinic receptors. 5. The analogue exhibited less cardiac depressant action on left ventricular rate (dp/dt) and force of contraction than lignocaine. 6. Lethal effects for the analogue were first observed at 16 mg/kg following intravenous administration and at 500 mg/kg following intraperitoneal administration. 7. In conclusion, ...

185

Probable role of trace elements of some medicinal plants in cardio-vascular diseases

The atrial myocardium has been barely visible with thallium-201 myocardial scintigraphy. This is probably related to the difference in size, distance from anterior chest wall, and small coronary blood flow of the atrium, compared with the ventricle. We have encountered eight cases of visualization of the right atrial appendix (RAA). The RAA was identified from multiple projections in all cases and sometimes confirmed by radionuclide angiocardiography. Evidence derived from ECG, chest radiographs, and cardiac catheterization, indicated that the most important factor in the visualization might be the displacement of the RAA to a more anterior position.

1980-10-01

186

MRI in postoperative assessment of univentricular heart disease: correlation with echocardiography and angiography; MRT in der postoperativen Diagnostik bei funktionell univentrikulaerem Herz: Korrelation zu Echokardiographie und Kardangiographie

A number of herbal drugs are used in the Unani (Greco-Arab) System of Medicine for cardiovascular diseases. The herbs were analyzed by flame AAS and ICP-AES to determine if their therapeutic actions can be associated with the elements present in them. Cadmium, cobalt, chromium, copper, iron, potassium, magnesium, manganese, sodium, nickel, phosphorus, lead and zinc were some of the elements which play various roles in cardiovascular affections. An effort was made to correlate the role of these elements in cardiac diseases. (Auth.). 2 tabs., 32 refs.

187

Isolated laevocardia and corrected transposition of the great vessels with total situs inversus

Purpose: To determine the value of MRI in the postoperativ evaluation of a singular ventricle compared to echocardiography and cardiac catheterization. Materials and methods: Thirty-one patients (range: 6 months to 30 years) with a functional single ventricle following palliative corrective operations. Five patients had a Blalock-Taussig-Shunt, 8 patients a Glenn-Anastomosis and 18 a cavopulmonary shunt (6 with classic Fontan-Circulation, 12 with modified cavopulmonary anastomosis). The results in terms of postoperative morphologic changes were compared to percutaneous echocardiography (31/31) and cardiac catheterization (6/31). Results: Echocardiography, which was performed on all patients, could not visualize the entire length of the tunnel, the Glenn-Anastomosis or the central pulmonary arteries in 70% of the patients due to an inadequate acoustic window. MRI was able to show the entire tunnel in 11/12 patients and the central pulmonary ...

2002-12-01

188

Hypersersensitivity and Kounis syndrome due to a viper bite

Isolated laevocardia combined with corrected transposition of the great arteries and complete situs inversus is rare. Due to discordant interrelationships between atria and ventricles and between ventricles and great arteries, both anomalies result in a normal circulation. In the presented case no associated cardiac malformations were present and the 55-year-old woman remained symptom-free for a long time until she developed an acquired valve disease. A systematic approach to chamber localisation in complex morphologic lesions of the heart is reviewed, and the value of CT, which can be applied successfully in older children and adults is demonstrated. (orig.).

189

British Library Electronic Table of Contents (United Kingdom)

A 60-year-old male was bitten by a venomous snake (Vipera ammodytes) and gradually developed signs of an allergic reaction including generalized itching, generalized rash, and chest discomfort. This was followed by severe retrosternal pain with electrocardiographic evidence of an inferior myocardial ischemia progressing to acute myocardial infarction. Cardiac enzymes and troponin, serum tryptase, and histamine were elevated. Coronary arteriography showed normal coronary arteries. This is a characteristic type I variant of Kounis syndrome, which is the concurrence of acute coronary syndromes with conditions associated with mast cell activation including allergic or hypersensitivity reactions as well as anaphylactic or anaphylactoid reactions. This is the first report to show that viper bite...

2006-01-01

190

Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level

Improved detection of myocardial infarction with technetium-99m stannous pyrophosphate and serum MB creatine phosphokinase

Lanthanide-ion doped oxide nanoparticles were functionalized for use as fluorescent biological labels. These nanoparticles are synthesized directly in water which facilitates their functionalization, and are very photostable without emission intermittency. Nanoparticles functionalized with guanidinium groups act as artificial toxins and specifically target sodium channels. They are individually detectable in cardiac myocytes, revealing a heterogeneous distribution of sodium channels. Functionalized oxide nanoparticles appear as a novel tool particularly well adapted to long-term single-molecule tracking.

2005-04-01

191

Estimation of the parameter covariance matrix for aone-compartment cardiac perfusion model estimated from a dynamic sequencereconstructed using map iterative reconstruction algorithms

The relative sensitivity and combined value of myocardial technetium-99m stannous pyrophosphate imaging and determinations of serum MB creatine phosphokinase (the ''myocardial'' CPK isoenzyme) in detecting acute myocardial infarction were evaluated in 41 patients with suspected infarction and 23 patients recovering from cardiac surgery. In the patients with suspected infarction, myocardial infarction was confirmed in 25 and was consistently associated with increased serum MB CPK. Abnormal radionuclide images were obtained in 23 of 25 patients (92%)) with definite myocardial infarction and in 2 of 16 patients without confirmed infarction. Although the localization of infarction by imaging correlated well with the localization by electrocardiogram, infarct size estimated by imaging did not correlate well with estimates based on peak total serum CPK activity or serial changes in CPK activity. Serum MB CPK activity increased after cardiac surgery ...

192

The effects of surface damage on RF cavity operation

In dynamic cardiac SPECT estimates of kinetic parameters ofa one-compartment perfusion model are usually obtained in a two stepprocess: 1) first a MAP iterative algorithm, which properly models thePoisson statistics and the physics of the data acquisition, reconstructsa sequence of dynamic reconstructions, 2) then kinetic parameters areestimated from time activity curves generated from the dynamicreconstructions. This paper provides a method for calculating thecovariance matrix of the kinetic parameters, which are determined usingweighted least squares fitting that incorporates the estimated varianceand covariance of the dynamic reconstructions. For each transaxial slicesets of sequential tomographic projections are reconstructed into asequence of transaxial reconstructions usingfor each reconstruction inthe time sequence an iterative MAP reconstruction to calculate themaximum a priori reconstructed estimate. Time-activity curves for a sumof activity in a blood ...

2004-01-01

193

Examples of damages in stationary gas turbines; Beispielhafte Schaeden an stationaeren Gasturbinen

We describe a model of damage in rf cavities and show how this damage can limit cavity operation. We first present a review of mechanisms that may or may not affect the ultimate fields that can be obtained in rf cavities, assuming that mechanical stress explains the triggers of rf breakdown events. We present a method of quantifying the surface damage caused by breakdown events in terms of the spectrum of field enhancement factors, Beta, for asperities on the surface. We then model an equilibrium that can develop between damage and conditioning effects, and show how this equilibrium can determine cavity performance and show experimental evidence for this mechanism. We define three functions that quantify damage, and explain how the parameters that determine this performance can be factored out and measured. We then show how this model can quantitatively explain the dependence of ...

2006-04-14

194

Displacement damage cross sections for neutron-irradiated silicon carbide

The examples quoted show that damage is mostly due to faults of design and construction or faulty operation. The ever shorter development cycles, the further development of existing constructions and cost pressure owing to price slumps are very important in this context. Careful endoscopic inspections and monitoring and early identification of beginning damage helps to prevent major damage and follow-up damage. The causes of changing operational performance must be established as early as possible to prevent larger damages from being caused by continued operations.(orig.) [German] Die vorgestellten Schadenbeispiele zeigen, dass die Schaeden vorwiegend durch Auslegungsfehler und Konstruktionsfehler aber auch durch Bedienungsfehler verursacht wurden. Die immer kuerzeren Entwicklungszeiten fuer Neukonstruktionen und die Weiterentwicklung vorhandener Konstruktionen sowie der Kostendruck ...

1998-07-01

195

Displacement Damage Cross Sections for Neutron-irradiated Silicon Carbide

Displacements per atom (DPA) is a widely used damage unit for displacement damage in nuclear materials. Calculating the DPA for SiC irradiated in a particular facility requires a knowledge of the neutron spectrum as well as specific information about displacement damage in that material. In recent years significant improvements in displacement damage information for SiC have been generated, especially the energy required to displace an atom in an irradiation event and the models used to describe electronic and nuclear stopping. Using this information, numerical solutions for the displacement functions in SiC have been determined from coupled integro-differential equations for displacements in polyatomic materials and applied in calculations of spectral-averaged displacement cross sections for SiC. This procedure has been used to generate spectrally averaged displacement cross sections for SiC in a ...

2002-12-01

196

Tetracycline in uranyl nitrate intoxication: Its action on renal damage and U retention in bone

Displacements per atom (DPA) is a widely used damage unit for displacement damage in nuclear materials. Calculating the DPA for SiC irradiated in a particular facility requires a knowledge of the neutron spectrum as well as specific information about displacement damage in that material. In recent years significant improvements in displacement damage information for SiC have been generated, especially the energy required to displace an atom in an irradiation event and the models used to describe electronic and nuclear stopping. Using this information, numerical solutions for the displacement functions in SiC have been determined from coupled integro-differential equations for displacements in polyatomic materials and applied in calculations of spectral-averaged displacement cross sections for SiC. This procedure has been used to generate spectrally averaged displacement cross sections for SiC in a ...

2002-12-01

197

Simulation of concrete perforation based on a continuum damage model

In acute intoxication, uranium (U) not only inhibits bone formation but its excretion in urine also causes renal damage. The former effect is ameliorated by tetracycline (TC), probably due to its chelation property, which might also prevent U deposition in bone. Chemical determination of U incorporated in bone and a histological study of the kidneys were performed on animals injected with U and then treated with TC. The results showed that TC was unable to prevent the binding of U to bone while it exacerbated U-induced renal damage.

1989-09-01

198

Response surface characterization of impact damage and residual strength degradation in composite sandwich panels

Numerical simulation of dynamic fracture of concrete slabs, impacted by steel projectiles, was carried out in this study. The concrete response was described by a continuum damage model. This continuum damage model was originally developed to study rock fragmentation and was modified in the present study with an emphasis on the post-limit structural response. The model was implemented into a transient dynamic explicit finite element code LS-DYNA2D and the code was then used for the numerical simulations. The specific impact configuration of this study follows the experiment series conducted by Hanchak et al. Comparisons between calculated results and measured data were made. Good agreements were found.

1994-10-01

199

Randomization of heavily damaged regions in annealed low energy Ge{sup +}-implanted (0 0 1)Si

The influence of material configuration and impact parameters on the damage tolerance characteristics of sandwich composites comprised of carbon-epoxy woven fabric facesheets and Nomex honeycomb cores was investigated using empirically based response surfaces. A series of carefully selected tests were used to isolate the coupled influence of various combinations of the number of facesheet plies, core density, core thickness, impact energy, impactor diameter, and impact velocity on the damage formation and residual strength degradation due to normal impact. The ranges of selected material parameters were typical of those found in common aircraft applications. The diameter of the planar damage area associated with Through Transmission Ultrasonic C-scan measurements and the peak residual facesheet indentation depth were used to describe the extent of internal and detectable surface damage, respectively. ...

2003-01-01

200

Randomization of heavily damaged regions in annealed low energy Ge"+-implanted (0 0 1)Si

Apparent growth of amorphous layers during low temperature annealing was observed in low energy Ge{sup +}-implanted (0 0 1)Si by high-resolution transmission electron microscopy. The occurrence of abnormal growth is due to the randomization of heavily damaged regions beneath the original amorphous/crystalline interfaces. The randomization process is attributed to the strain, incurred by the presence of a high density of large Ge atoms in the heavily damaged Si substrate, relaxation to lower the free energy of the systems. The randomization upon annealing may be fruitfully applied to minimize the transient enhanced diffusion in shallow junction formation.

2004-01-15

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201

Apparent growth of amorphous layers during low temperature annealing was observed in low energy Ge"+-implanted (0 0 1)Si by high-resolution transmission electron microscopy. The occurrence of abnormal growth is due to the randomization of heavily damaged regions beneath the original amorphous/crystalline interfaces. The randomization process is attributed to the strain, incurred by the presence of a high density of large Ge atoms in the heavily damaged Si substrate, relaxation to lower the free energy of the systems. The randomization upon annealing may be fruitfully applied to minimize the transient enhanced diffusion in shallow junction formation.

2004-01-01

202

Radiobiology

Pipe whip: a summary of the damage observed in BNL pipe-on-pipe impact tests

This text-book (electronic book - multi-media CD-ROM) constitutes a course-book - author's collection of lectures. It consists of 13 lectures in which the reader acquaints with the basis of radiobiology: Introduction to radiobiology; Physical fundamentals of radiobiology; Radiation of cells; Modification of radiation damage of cells; Reparation of radiation damage of cells; Radiation syndromes and their modification; Radiation injury; Radiation damage of tissues; Effect of radiation on embryo and fetus; Biological effects of incorporated radionuclides; Therapy of acute irradiation sickness; Delayed consequences of irradiation; Radiation oncology and radiotherapy. This course-book may be interesting for students, post-graduate students of chemistry, biology, physics, medicine as well as for teachers, scientific workers and physicians. (author)

203

Pipe whip: a summary of the damage observed in BNL pipe-on-pipe impact tests

This paper describes examples of the damage resulting from the impact of a whipping pipe on a nearby pressurised pipe. The work is a by-product of a study of the motion of a whipping pipe. The tests were conducted with small-diameter pipes mounted in rigid supports and hence the results are not directly applicable to large-scale plant applications where flexible support mountings are employed. The results illustrate the influence of whipping pipe energy, impact position and support type on the damage sustained by the target pipe.

1987-01-01

204

On the Permeability of Thermally Damaged PBX 9501

This paper describes examples of the damage resulting from the impact of a whipping pipe on a nearby pressurised pipe. The work is a by-product of a study of the motion of a whipping pipe. The tests were conducted with small-diameter pipes mounted in rigid supports and hence the results are not directly applicable to large-scale plant applications where flexible support mountings are employed. The results illustrate the influence of whipping pipe energy, impact position and support type on the damage sustained by the target pipe. (author).

205

British Library Electronic Table of Contents (United Kingdom)

Theoretical analysis, modeling, and simulation are used to provide insight into the development of permeability during thermal damage of the high explosive PBX 9501. In a recently published article, Terrones et al. [1] conclude that samples of PBX 9501 thermally damaged at 186 degreeC are not permeable to gas flow in a manner consistent with Darcys Law. We disagree with their conclusion. We show that they have misreported data from the literature, and that their argument depends on a fluid flow model that is physically incorrect and is applied with inappropriate physical parameters.

2007-01-01

206

International law on nuclear liability - a critical approach

The Influence of Interleukin-4 on Ligament Healing

The author discusses in detail the following topics: Compensation for domestic nuclear damage and for transfrontier nuclear damage - rule of formal equality of parties which belongs to the basic rule of civil law considering the position of domestic and foreign victims of a grave accident-juridical consequences of the preponderant role played by the state in the promotion, development and supervision of the nuclear industry-rationale for applying the concept of global limitation of liability in the law on nuclear liability and compensation - financial consequences of uncompensated nuclear damage, borne by the victims directly affected or spread over the whole community of the affected state? (HP)

1995-12-31

207

Spread dynamics of invasive species

Despite a complex cascade of cellular events to reconstruct the damaged extracellular matrix, ligament healing results in a mechanically inferior scarred ligament. During normal healing, granulation...Full Text Available

2011-05-01

208

Soil Moisture Monitoring for Agriculture

Species invasions are a principal component of global change, causing large losses in biodiversity as well as economic damage. Invasion theory attempts to understand and predict invasion success and...Full Text Available

2006-01-10

209

International Science & Technology Center (ISTC)

Elaboration of a Modern Technology for Operational Agrometeorological Soil Moisture Monitoring Spring Wheat, Yield and Disease Damage Forecasting and Recommendations for Plant Protection on the Kazakhstan Territory

210

Regulation of Senescence in Cancer and Aging

Recommendations for the prevention of damage to steam turbines. 2. rev. ed.

Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically...Full Text Available

211

Part Repairing Using A Hybrid Manufacturing System (Preprint ...

The purpose of the recommendation is to prevent, to detect, and to remove soiling of guide and retrating blades of steam turbines, e.g. on account of foreign matter in steam dissolved. (TK/LN).

212

NASA SBIR 98-1 Award by Firm - NASA's SBIR & STTR Programs

... [11]Richter, K., Orban, S., and Nowotny, S., Laser cladding of the titanium alloy TI6242 to restore damaged blades, Proceedings of the 23rd ...

2007-03-01

213

Medium voltage analytical electron microscopy microanalysis versus radiation damage

Design of Damage-Tolerant Composite Sandwich Panels with Tear Straps. Sukra Helitek Inc. 3146 Greenwood Road. Ames, IA 50014-4504 ...

214

Laser Induced Damage to Nonlinear Optical Materials

The kinetic energy transferred to some elements by an electron of kinetic energy 100 to 400 kV is discussed. The displacement rates are compared to the signal generation. (DCL)

1985-09-01

215

Impacts of Hugo Timber Damage on Primary Wood Manufacturers in ...

... a rotating mirror Q-switch or an acousto-optic Q-switch. The former ... Q-switch up to 2000 pps. The Q-switched output bean, is predominantly ...

1972-09-01

216

Immunomodulation of Autoimmune Arthritis by Herbal CAM

Description: Hurricane Hugo, which struck South Carolina in September of 1989, destroyed a significant proportion of the State's timber. Primary wood-products ...

217

Hydrogen induced damage in pickled and anodized Ti--6Al--4V alloy surfaces

Rheumatoid arthritis (RA) is a debilitating autoimmune disease of global prevalence. The disease is characterized by synovial inflammation leading to cartilage and bone damage. Most of the conventional...Full Text Available

2011-01-01

218

HDL in humans with cardiovascular disease exhibits a proteomic signature

(Sep 1974). United States Das, KB Marceau, JA Boeing Co., Seattle

219

Experiments on determination of damage effect ions "2"2Ne (172 MeV) on UO_2 monocrystals

BackgroundAlterations in protein composition and oxidative damage of high-density lipoprotein (HDL) have been proposed to impair the cardioprotective properties of...Full Text Available

2010-07-04

220

Economic assessment of air pollution. Economic evaluation of the effects of air pollution

Shadow effect was used for investigating damage of uranium dioxide monocrystal. The dependence of shadow minimum parameters on fluence of "2"2Ne ions with 172 MeV energy was followed when detecting fission fragments. Ion dose responsible for sufficient microdamage of lattice structure, included into the classification of heavy ion damage effect on monocrystals was determined. The problem of radiation intensity effect on the character of occurred damages was studied. It was established that macroscopic sample failure, caused by generation of considerable mechanical stresses in monocrystal under beam effect could be observed along with microdamages of lattice structure at ion flux density >10"1"2 cm"-"2Xs"-"1.

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221

Design of Damage-Tolerant Composite Sandwich Panels with Tear Straps

The cost incurred every year in West Germany due to air pollution is investigated. Damage to buildings, materials, and vegetation are evaluated as well as the cost of additional cleaning work and changes of location with the objective of getting a picture of the economic value of air pollution abatement. The findings are based on data of immission damage in high-exposure areas. Damage is assessed in consideration of the frequency of repair measures in industrial and country atmosphere. Further research will be necessary in view of the many problems concerning methods and availability of basic statistical data. The sequential cost estimated for a few selected cases of damage show that economic losses due to air pollution amount to several thousand million DM. Air pollution abatement measures thus do not only improve our quality of life but also help to save considerable cost to our national economy.

1980-01-01

222

DNA synthesis inhibition in mammalian cells as a test for mutagenic carcinogens

The objectives of the Phase-I research address the development of mechanics- based structural integrity analysis methodologies for composite sandwich panels ...

223

Cellular and Molecular Mechanisms of Bone Remodeling*

Current models of DNA repair of biological damage are reviewed correlating the similarity between carcinogenesis and mutagenesis theories. (PCS)

1979-01-01

224

An Experimental Investigation of Sandwich Flat Panels Under ...

Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis. In addition to...Full Text Available

2010-08-13

225

A $G_{4}$ Sequence within PHR1 Promoter Acts as a Gate for Cross-Talks between Damage-Signaling Pathway and Multi-Stress Response

... Figure 1.4. Low Velocity Impact 1-4 Page 25. Damage of composite sandwich panels caused by low velocity impact has been ...

1994-12-01

226

Study of silicon damage caused by ultra-low energy boron implantation

Full Text Available

2002-09-01

227

Monitoring of DNA and cytogenetic damage in lymphocytes from persons with skin cancer diseases

Ultra-shallow junction formation in deep submicron Si devices is limited by anomalous diffusion of the dopant, which is related to the release of interstitials from defect clusters formed during the implantation of energetic ions or the subsequent annealing. The work described in this dissertation is concerned with the effects of low energy B ion implantation, especially damage formation, clustering and its annealing. After a review of the stopping and ranges of energetic ions in Si, the formation of implant damage, in particular of point defects, their migration, agglomeration and annihilation, including the involvement of dopant ions, is considered. A description of the Salford ultra low energy implanter is given and the main analysis technique, medium ion energy scattering (MEIS) reviewed. Additional analytical techniques used, such as secondary ion mass spectrometry (SIMS), 4-point probe and cross section transmission microscopy (XTEM) as ...

228

p73 protein regulates DNA damage repair.

There is a lot of interest in the studies that would help to understand whether there is a casual association between cancer and various types of molecular or cytogenetic damage detected in human cells. One major oncogenesis process is activation of proto-oncogenes by point mutations or chromosomal translocation. There are substantial evidence that indicates that the loss of heterozygosity of certain chromosomes is involved in human cancerogenesis. Our study aimed to elicit the possible association between cancer and DNA and cytogenetic abnormalities induced in lymphocytes of people bearing various categories of skin cancer cells. Fresh blood was collected by venipuncture from 25 individuals (including nine prior to cancer treatment). All patients were nonsmoking males, however 42.3 % of them were former smokers. Blood samples were divided into two parts and in the first part of samples cytogenetic studies were performed immediately, while from the second part ...

2004-11-01

229

Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel

Although the p53 tumor suppressor is relatively well characterized, much less is known about the functions of other members of the p53 family, p73 and p63. Here, we present evidence that in specific pathological conditions caused by exposure of normal cells to bile acids in acidic conditions, p73 protein plays the predominant role in the DNA damage response. These pathological conditions frequently occur during gastric reflux in the human esophagus and are associated with progression to esophageal adenocarcinoma. We found that despite strong DNA damage induced by bile acid exposure, only p73 (but not p53 and p63) is selectively activated in a c-Abl kinase-dependent manner. The activated p73 protein induces DNA damage repair. Using a human DNA repair PCR array, we identified multiple DNA repair genes affected by p73. Two glycosylases involved in base excision repair, SMUG1 and MUTYH, were characterized and found to be ...

2011-09-01

230

The superconducting critical temperature of radiation damaged A-15 compounds

BackgroundThe Mre11/Rad50/Nbs1 (MRN) complex is a regulator of cell cycle checkpoints and DNA repair. Defects in MRN can lead to defective S-phase arrest when cells are damaged....Full Text Available

231

The stability of synthetic cutting fluids to microbe damage

A simple model is used to explain the decrease in superconducting critical temperature with damage observed for irradiated A-15 compounds. A truncated t-matrix approximation is used to describe the disorder along the one-dimensional transition metal chains. Three dimensionality is introduced by the inclusion of interaction between transition metal atoms on different chains. Numerical fits to experiment are discussed in the conclusion. (author).

232

Study of implantation damage in germanium formed using Ga"+ FIB

The resistance to microbe damages of aqueous solutions of cutting fluids (SOZh), which contain dual and more complex mixtures of known compounds, is studied. Lauric acid, myristic and tridecanic acid give microbic resistance to the compositions of synthetic cutting fluids. A complexing of the compositions as a rule does not support precisely expressed effects of synergism or antagonism.

1983-01-01

233

Steam turbine operation and damages after long term use; Dampfturbinenbetrieb und Schaeden nach langer Einsatzzeit

Full text: It is known that the ion implantation of germanium single crystals at room temperature results in drastic alteration of the germanium surface and the formation of cellular relief. Voids were found into the near-surface damage layer. The intersection of these voids with the germanium surface, as result of sputter etching, forms cellular relief. However, exact mechanism responsible for formation of the voids is not known. A 10 and 30 keV Ga"+ irradiation of Ge #left brace#100#right brace# crystal at room temperature was carried out using a focused ion beam (FIB) system with a dose in the range 0.5x10"1"2 to 1.5x10"1"4 ion/cm"2. The topology of the modified germanium surface and the structure of the radiation damage was studied using imaging facilities of the FIB systems and transmission electron microscopy. The strong cellular structure of Ge was observed after an ion dose of 3x10"1"3 ion/cm"2. High-resolution TEM showed a complex ...

234

Steam turbine blade damage; Schaeden an Dampfturbinenbeschaufelungen

Allianz Global Corporate and Specialty AG, the industrial insurance carriers of Allianz Group and AZT Risk and Technology GmbH, have a lot of experience and a comprehensive database about damage of industrial steam turbines and large-scale power generation turbosets. Sound maintenance concepts are the main loss prevention measure, which will be presented and discussed in detail. Some modifications and additions to existing maintenance concepts are also provided.

2008-07-01

235

Safety provisions for steam generator in Mochovce nuclear power plant. BO CI 04 Integrity of primary collectors of VVER 440 steam generators

Blades of modern steam turbines are designed for high efficiency and operational safety. Modern computer programs enable optimisation of design but factors like manufacturing, assembly, operation and downtimes still play an important role. Damage statistics show that blade damage still quite frequent. Selected cases from the Allianz damage assessment centre show some of the more frequent damage mechanisms. Damage is often caused when several factors come together. Prevention of follow-up damage requires early identification of beginning damage.(orig.) [German] Die Auslegung der Beschaufelung moderner Dampfturbinen hat die Vorgabe, einen hohen Wirkungsgrad bei gleichzeitig hoher Betriebssicherheit zu erreichen. Mit den heute zur Verfuegung stehenden Rechenprogrammen ist eine entsprechende Optimierung realisierbar. Fuer die langzeitige ...

1998-07-01

236

SWI/SNF and Asf1 Independently Promote Derepression of the DNA Damage Response Genes under Conditions of Replication Stress

This paper dealt with the identification of possible damaging mechanism of the collector of the WWER 440 steam generator, cracking of primary collectors, corrosion damage of the protective coat of the primary collector circumferential weld, cracking of breathing space in the region of blinding effect by corrosion and strain, leaking of disassembling joint of the primary collector lid and with the integrity of heat exchanging tubes.

1997-11-19

237

Nuclear power plants and the ''dying forests''

The histone chaperone Asf1 and the chromatin remodeler SWI/SNF have been separately implicated in derepression of the DNA damage response (DDR) genes in yeast cells treated with genotoxins that cause...Full Text Available

238

Methods and results of a representative analysis of the radiation exposure of the population by diagnostic radiology

Possible causes of forest damage are discussed. Mapping of affected areas by various workers resulted in dissimilar pictures. Release of radioactive rare gases, aerosols, tritium and carbon-14 seems unlikely to have a significant influence on forest damage. Influence of radioactive fallout, ozone formation by high-voltage transmission lines and synergistic effects is also found to be negligible.

1985-01-01

239

Major steam turbine losses. Causes, repair measures, recommissioning; Grossschaeden an Dampfturbosaetzen. Ursachen, Reparaturen, Weiterbetrieb

From the frequency of diagnostic radiologic examinations and their radiation dose delivered to the population the risk of cancer induction and genetic damage is calculated on the basis of the risk factors given by the ICRP. Thus 0.38 % and 3 % of the total mortality for cancer and leukemia, resp., can be attributed to X-ray diagnostics. Chest examinations alone result in 0.07-0.7 damages per 100,000 persons depending on the imaging technique applied. (author).

1984-01-01

240

LEGAL AND INSTITUTIONAL FRAMEWORK FOR CONFLICTS BETWEEN CONSERVATION AND THE USE OF BIOLOGICAL RESOURCES

Substantial damages at main components of steam turbines do not have to result inevitably in an exchange of the components concerned. Rather a preliminary or final repair is possible which also considers the cause of the damage. An important condition with the technically complex questions is an appropriate qualification and experience of all involved persons. The common task of operators, manufacturers and insurance companies is to preserve the balance from costs, expenditure of time and risk.

2010-07-01

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241

Wastenet

sinensis), the otter (Lutra lutra) and the grey seal (Halichoerus grypus) can be mentioned as ...conflict relates to damage caused by the grey seal to coastal fisheries, whereas in Germany damages ...For example species like the grey seal involved in the conflicts may benefit from the by-catch regulation.

242

Causes of PGV-1000 horizontal steam generator 'cold' collector damages and ways of improving their operation reliability and service life

CRC handbook of laser science and technology. Volume 3. Optical materials, Part 1 - Nonlinear optical properties/radiation damage

Specifications of the PGV-1000 steam generators applied at the WWER-1000 NPP power units, operational experience and data on damages at the 'cold' heat carriers of steam generators are considered and their results are presented. Developed and introduced measures aimed at improving reliability and operational life of the PGV-1000 collectors are described.

1993-01-01

243

Biological effects and health risks following to the exposition to ionizing radiation

This book examines the nonlinear optical properties of laser materials. The physical radiation effects on laser materials are also considered. Topics considered include: nonlinear optical properties; nonlinear and harmonic generation materials; two-photon absorption; nonlinear refractive index; stimulated Raman scattering; radiation damage; crystals; and glasses.

1986-01-01

244

An immunochemical approach to the study of DNA damage and repair

Late somatic and genetic radiation effects are imperfectly understood, particularly in the human species. However the available information is sufficient to draw reasonably precise risk estimates in man for many types of damage by means of scientifically justifiable procedures and with the necessary caution. This overall absolute risk of major somatic and genetic damage may be set at around 10"-"4/rad of chronic whole-body doses.

1976-01-01

245

A solution for solid state detector and preamplifier protection, during HV application and removal transition periods

The overall objective of this project is to produce antibodies to unique modified DNA bases and develop immunochemical assays to quantitate these lesions in damaged DNA. During this past year we have developed an antibody and chemical test to quantitate a basic sites in DNA and produced antibodies to the 8-oxopurines. This report discusses the detection of a basic sites in DNA and the preparation of antibodies to 8-hydroxyadenine and 8-hydroxyguanine.

1990-11-14

246

A management scheme for reducing pollution at air discharge facility in advance

Surface barrier detectors may be damaged, because of microplasma breakdown, in rapid application of bias voltage. The high performance FETs of very low noise preamplifiers may also be damaged by rapid changes of the bias voltage. The electronic device described permits the gradual application and removal of the bias voltage, without any influence on the power supply specification. (Auth.).

247

The influence of prior ageing on creep damage development in two variants of Alloy 800

The developed countries are implementing a policy minimizing damage from environmental pollution by reducing discharge in advance as well as the aftermath of a pollutant. The typical example is to use BAT (Best Available Technology). This is to prevent environmental damage by reducing the discharge of pollutants with available technology and to secure environmental margin to enable industrial activities of future generation. Therefore, the feasibility of introducing BAT requirement system was reviewed by considering foreign examples and Korean situation. 38 refs., 8 figs., 69 tabs.

1998-12-01

248

An immunochemical approach to the study of DNA damage and repair. Technical progress report, May 1, 1989--April 30, 1992

The influence of high temperature thermal ageing treatments on the development of intercrystalline creep damage in two variants of Alloy 800 has been investigated. Ageing up to 3000 h and creep testing were carried out at 800 and 900 C. The high temperature behaviour of the 800HT variant is discussed with reference to the effect of heat treatments on the microstructure. The metallographic methods by which the creep damage was quantitatively determined are described. The growth rate of intercrystalline microcracks was described using a statistical model and the dependence of crack growth rate on the thermal history for both 800HT and 800H was determined. The carbide precipitation and growth processes were determined as functions of the exposure temperature and duration. The results showed the three characteristic stages, precipitation, growth and coarsening (Ostwald ripening). The largest increase in the intergranular creep ...

1997-06-01

249

An immunochemical approach to the study of DNA damage and repair

The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on ...

1992-05-01

250

Role of nuclear medicine and magnetic resonance imaging in cardiac diagnostics; Rolle der nuklearmedizinischen Verfahren und der Magnetresonanztomographie in der kardialen Diagnostik

The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on ...

1992-05-01

251

[Pulmonary vascular manifestations in hereditary hemorrhagic telangiectasia].

Nuclear medicine and magnetic resonance imaging (MRI) are widely used in cardiac diagnostics. Both techniques have been carefully evaluated and are equivalent for the assessment of regional and global wall motion as well as the evaluation of ejection fraction and cardiac volumes, though MRI is herein currently seen as gold standard. For evaluation of myocardial perfusion, extensive data exist for nuclear imaging, that, next to high diagnostic accuracy for evaluation of coronary artery disease, show incremental prognostic information and allow for independent risk stratification. Because of rapid technical advance, myocardial perfusion imaging has also become feasible with cardiac MRI. Results of recent studies are promising, but the data are few compared to perfusion scintigraphy. For viability assessment in patients with ischemic cardiomyopathy, positron emission tomography (PET) with FDG is currently seen as gold ...

2003-12-01

252

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI): final 5-year results suggest long-term safety and efficacy

Hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) is a genetic disorder with autosomal dominance, variable penetrance, and an estimated prevalence of 1/10,000 inhabitants in France. Diagnosis is based on clinical criteria including epistaxis, telangiectasia, visceral manifestations, and familial occurrence. Pulmonary arteriovenous malformations, present in 15-33% of patients, are its primary visceral complications. The disease may be revealed by infectious and ischemic neurological manifestations due to paradoxical embolism. The high frequency of neurologic complications even in asymptomatic patients justifies systematic screening for pulmonary arteriovenous malformations. Treatment of these malformations is based on percutaneous transcatheter coil embolization of the feeding artery. Pulmonary arterial hypertension is rare in this disease. It may be due to systemic arteriovenous shunting in the liver, which increases cardiac output, or be similar to ...

2005-11-01

253

British Library Electronic Table of Contents (United Kingdom)

Background Limited data is available for investigating the long-term safety and effects of intracoronary progenitor cell therapy in patients with acute myocardial infarction (AMI). Objective To assess the clinical course, NT-proBNP and MRI data as objective markers of cardiac function of the TOPCARE-AMI patients at 5-year follow-up. Design The TOPCARE-AMI trial was the first randomized study investigating the effects of intracoronary infusion of circulating (CPC) or bone marrow-derived progenitor cells (BMC) in 59 patients with successfully reperfused AMI. Results Five-year follow-up data were completed in 55 patients, 3 patients were lost to follow-up. None of the patients showed any signs of intramyocardial calcification or tumors at 5?years. One patient died during the initial hospitali...

2011-01-01

254

Reduction in incidence of deep sternal wound infections: Random or real?

British Library Electronic Table of Contents (United Kingdom)

Objective Comorbidities predisposing cardiac surgical patients toward deep sternal wound infection, such as diabetes and obesity, are rising in the United States. Longitudinal analysis of risk factors, morbidity, and mortality was performed to assessed effects of these health trends on deep sternal wound infection rates. Methods In this retrospective analysis of all median sternotomies performed at a single institution from 1991 through 2006, demographic and surgical characteristics were identified from a prospective database. The cohort was separated into periods from 1992 through 2001 and 2002 through 2006 to identify longitudinal trends in risk factors for deep sternal wound infection. Univariate and matched multivariable analyses were performed. Results Overall, study population had in...

2010-01-01

255

Random walk function in the analysis of time-activity curves from dynamic radionuclide studies

Radio cellular phones and health: Up-to-date research on human health; Radiotelephones cellulaires et sante: mise au point des recherches portant sur la sante chez l'homme

The random walk function is a mathematical function derived from studies of the mass transport and flow of diffusible materials through tubes. Approximations to the function were first used some time ago in the field of cardiac tracer dilution curves, but in the absence of rapid and reproducible curve fitting the method never became commonplace. The current study uses the latest curve-fitting techniques and shows how the method may be used with precision in the analysis of time-activity curves from dynamic oesophageal and blood flow studies. The physiological basis of the method is given and parameters obtained which relate to both the rate of flow and the local dispersion of the bolus.

1987-04-01

256

Prognostic value of plasma B-type natriuretic peptide in patients with severe cardiotoxic drug poisoning

Cellular telephones emit a radiofrequency electromagnetic field, part of which is absorbed in the user's head. Many studies have been conducted to look for their possible health hazard to human, at the experimental, epidemiological or clinical level. After a short recall on dosimetry, the author describes the state-of-the art about harmful and irreversible effects, up to now not confirmed, and about some benign symptoms which look absolutely actual. A causal relationship of the electromagnetic field on these benign symptoms is however not proven; other, studies are running to evaluate their possible long-term consequences. Interferences with cardiac pacemakers can easily be avoided by holding the telephone handset farther than 10 cm. (author)

1999-12-01

257

British Library Electronic Table of Contents (United Kingdom)

Background/Objectives: Cardiotoxic drug poisoning can lead to severe cardiac shock (CS) and death. B-type natriuretic peptide (BNP) is a well-established diagnostic and prognostic marker in heart failure but has never been assessed in patients with cardiotoxic drug poisoning. The aim of the study was to determine whether BNP could be useful for early stratification of patients admitted to intensive care unit. Methods: 30 consecutive patients experiencing shock and cardiotoxic drug exposure were enrolled in a prospective monocentric study and underwent at least two BNP measurements within the first 24 h after admission. Results: While BNP values on admission were poorly informative, subsequent BNP measurements (11 +- 6 h after admission) were significantly increased in patients with CS comp...

2011-01-01

258

Mother and infant coordinate heart rhythms through episodes of interaction synchrony

British Library Electronic Table of Contents (United Kingdom)

Animal studies demonstrated the powerful impact of maternal-infant social contact on the infant's physiological systems, yet the online effects of social interactions on the human infant's physiology remain poorly understood. Mothers and their 3-month old infants were observed during face-to-face interactions while cardiac output was collected from mother and child. Micro-analysis of the partners' behavior marked episodes of gaze, affect, and vocal synchrony. Time-series analysis showed that mother and infant coordinate heart rhythms within lags of less than 1s. Bootstrapping analysis indicated that the concordance between maternal and infant biological rhythms increased significantly during episodes of affect and vocal synchrony compared to non-synchronous moments. Humans, like other mamm...

2011-01-01

259

Improving surgical outcome following the Norwood procedure

British Library Electronic Table of Contents (United Kingdom)

Background The Norwood procedure consists of three palliative operations, performed in neonates with hypoplastic left heart syndrome. Especially the first stage (Norwood I) is associated with the highest mortality rates in paediatric cardiac surgery (up to 25%). During surgery, the aorta is reconstructed and a systemic-to-pulmonary shunt is applied. Originally the modified Blalock-Taussig shunt was used, but recently the right-ventricle-to-pulmonary-artery shunt is increasingly being employed. We reviewed the results of our operative strategy, where an individualised choice of shunt is made. Furthermore, attempts to reduce interstage mortality (between Norwood I and II) were assessed. Methods All neonates who underwent Norwood stage I palliation from August 2004 until November 2010 were in...

2011-01-01

260

Human brain development in infants with PET and FDG

Evaluation of Neonatal Membrane Oxygenators With Respect to Gaseous Microemboli Capture and Transmembrane Pressure Gradients

The authors used studies of local cerebral metabolic rate for glucose (LCMRGlc) to examine development of cerebral organization in 5 days to 1 year old children. A group (n=8) of infants with diverse pediatric disorders allowed investigation of developmental changes in LCMRGlc, while also providing relevant clinical management information. Patients consisted of questionable and definite neonatal seizures, cerebral embolism from cardiac sources, and otherwise normal infants with facial nevi with consideration of Sturge-Weber. Gradual increase in cortical LCMRGlc coincides with suppression of intrinsic subcortical reflexes present in all newborns. Two retarded children (2 years old) showed LCMRGlc developmental patterns of a few days old, which corresponded to their functional and mental status. These studies illustrate great potential of PET to study normal and altered states of human brain development.

1985-06-02

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261

British Library Electronic Table of Contents (United Kingdom)

Abstract A series of studies performed at our center demonstrates that gaseous microemboli (GME) remain a challenge in cardiac surgical procedures. Evaluation of novel oxygenators must address hemodynamic parameters and microemboli capture capability. The objective of this study is to compare two neonatal membrane oxygenators, the Quadrox i (MAQUET Cardiopulmonary AG, Hirrlingen, Germany) and the Capiox RX05 (Terumo Corporation, Tokyo, Japan), with respect to GME capture and hemodynamic energy delivery. The experimental circuit included a Maquet HL 20 heart lung machine, a Heater Cooler Unit HCU 30 (MAQUET Cardiopulmonary AG), a membrane oxygenator (Quadrox i Neonatal or Capiox RX05), and inch tubing from the COBE Heart/Lung Perfusion Pack (COBE Cardiovascular, Inc., Arvada, CO, USA). A Ca...

2010-01-01

262

Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agent

British Library Electronic Table of Contents (United Kingdom)

Aim:To examine the electrophysiological effects of sophocarpine on action potentials (AP) and ionic currents of cardiac myocytes and to compare some of these effects with those of amiodarone.Methods:Langendorff perfusion set-up was used in isolated guinea pig heart, and responses to sophocarpine were monitored using electrocardiograph. Conventional microelectrode, voltage clamp technique and perforated patch were employed to record fast response AP (fAP), slow response AP (sAP) and ionic currents in guinea pig papillary muscle or rabbit sinus node cells.Results:Tachyarrhythmia produced by isoprenaline (15 ?mol/L) could be reversed by sophocarpine (300 ?mol/L). Sophocarpine (10 ?mol/L) decreased the amplitude by 4.0%, maximal depolarization velocity (Vmax) of the fAP by 24.4%...

2011-01-01

263

Effects of rosiglitazone on the configuration of action potentials and ion currents in canine ventricular cells

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND AND PURPOSE In spite of its widespread clinical application, there is little information on the cellular cardiac effects of the antidiabetic drug rosiglitazone in larger experimental animals. In the present study therefore concentration-dependent effects of rosiglitazone on action potential morphology and the underlying ion currents were studied in dog hearts. EXPERIMENTAL APPROACH Standard microelectrode techniques, conventional whole cell patch clamp and action potential voltage clamp techniques were applied in enzymatically dispersed ventricular cells from dog hearts. KEY RESULTS At concentrations -10-M rosiglitazone decreased the amplitude of phase-1 repolarization, reduced the maximum velocity of depolarization and caused depression of the plateau potential. These effects d...

2011-01-01

264

Danger: high voltage

A model of a self-oscillatory process involving elements discretely distributed in space

Electric utilities have been surprised by recent opposition to the construction of very-high-voltage transmission lines, which met with little resistance in the past. Concerns over health and safety factors are associated with the increase in the number of such lines, although their presence has always been an inconvenience and a hazard for those living and working in the immediate vicinity. The new lines present additional hazards due to the continuous flow of small electric currents and the charges that build up in the area of the towers and lines. The lines are also a threat to persons wearing cardiac pacemakers. There is experimental evidence from the Soviet Union and the U.S. that electric and magnetic fields at the frequencies of such power lines can have serious biological effects on growth rates and the functioning of the central nervous system. Full disclosure that possible risks are involved and the opportunity to avoid these risks is a public ...

1978-05-01

265

Focused ion beam damage to MOS integrated circuits

Self-excited oscillations of a distributed medium can be investigated in terms of discrete physical models described by multidimensional systems of nonlinear equations which transform into equations of self-oscillating distributed media as the number of dimensions goes to infinity. Differential equations of such a self-oscillating system are set up and investigated. Coupling between elements of the medium, conditions under which the system constitutes an open system, internal impedance between the energy source and the system elements, and boundary conditions defining open and closed systems are discussed. The Gunn effect, eolian noise, self-oscillations of DNA molecules and of cardiac muscle, and wave processes in the cerebral cortex are mentioned as examples of self-oscillatory processes in question.

1975-01-01

266

Wound ballistics of gunshot injuries to the head and neck.

Commercial focused ion beam (FIB) systems are commonly used to image integrated circuits (ICS) after device processing, especially in failure analysis applications. FIB systems are also often employed to repair faults in metal lines for otherwise functioning ICS, and are being evaluated for applications in film deposition and nanofabrication. A problem that is often seen in FIB imaging and repair is that ICS can be damaged during the exposure process. This can result in degraded response or out-right circuit failure. Because FIB processes typically require the surface of an IC to be exposed to an intense beam of 30--50 keV Ga{sup +} ions, both charging and secondary radiation damage are potential concerns. In previous studies, both types of effects have been suggested as possible causes of device degradation, depending on the type of device examined and/or the bias conditions. Understanding the causes of this damage is ...

2000-05-10

267

Synergistic interaction of eugenol with antibiotics against Gram negative bacteria

It is important for the trauma surgeon to understand the basic principles of terminal gunshot ballistics and the study of the projectile's effect on striking soft tissue. The amount of kinetic energy dissipated to the tissue is directly related to the mass and velocity of the projectile as follows: K = MV2/2. Doubling the velocity quadruples the energy, while doubling the mass only doubles the energy. A temporary tissue cavity is produced as the striking projectile compresses the surrounding tissue; the higher the energy release, the more extensive the inapparent compressive damage. The permanent cavity that remains is the result of extrusion of tissue from the pathway of the projectile. The higher the velocity, the higher the likelihood of extensive damage. If the missile expands or fragments within the tissues, more damage will occur. PMID:6847483

1983-05-01

268

British Library Electronic Table of Contents (United Kingdom)

Eugenol, the principal chemical component of clove oil from Eugenia aromatica has been long known for its analgesic, local anesthetic, anti-inflammatory, and antibacterial effects. The interaction of the eugenol with ten different hydrophobic and hydrophilic antibiotics was studied against five different Gram negative bacteria. The MIC of the combination was found to decrease by a factor of 5-1000 with respect to their individual MIC. This synergy is because of the membrane damaging nature of eugenol, where 1mM of its concentration is able to damage nearly 50% of the bacterial membrane. Eugenol was also able to enhance the activities of lysozyme, Triton X-100 and SDS in damaging the bacterial cell membrane. The hydrophilic antibiotics such as vancomycin and b-lactam antibiotics which have ...

2009-01-01

269

Surface damage of mold steel and its influence on surface roughness of injection molded plastic parts

British Library Electronic Table of Contents (United Kingdom)

Plastic injection molds are an important economic sector due to the increasing use of injection molded plastic components. The selection of mold steel material, its processing conditions, and the way it is machined and hardened all have an impact on how it performs during use across its lifecycle for injection molding. For this study, injection molding conditions seen during high volume manufacturing were used to induce wear that would be typical during processing. A 50wt.% glass fiber reinforced Polybutylene Terephthalate (PBT) was used for the research. After 3000 injection operations, surface damage was found only on the steel used for the stationary half of the mold cavity and the corresponding surface of the molded parts. In contrast, the moving half showed no surface damage or increa...

2011-01-01

270

SSRM characterisation of FIB induced damage in silicon

Rapamycin (sirolimus) protects against hypoxic damage in primary heart cultures via Na^+/Ca^2^+ exchanger activation

Scanning spreading resistance microscopy (SSRM) has been applied to study focused ion beam (FIB) induced damage in silicon in dependence on ion irradiation doses from 10"1"2 cm"-"2 to 2#centre dot#10"1"6 cm"-"2. Starting from the lowest dose, SSRM detects increasing spreading resistance (SR) with increasing dose. For doses from 2#centre dot#10"1"3 cm"-"2 to 4#centre dot#10"1"4 cm"-"2, a slight decrease of SR is measured whereas for higher doses SR again slightly increases. The results are explained by physical effects like decreased carrier mobility due to increased scattering, amorphisation of silicon and precipitation of implanted Ga ions. The results clearly prove that SSRM is well suited for the fast detection of ion beam induced damage with high lateral resolution.

2008-03-01

271

British Library Electronic Table of Contents (United Kingdom)

Aims: Rapamycin (sirolimus) is an antibiotic that inhibits protein synthesis through mammalian targeting of rapamycin (mTOR) signaling, and is used as an immunosuppressant in the treatment of organ rejection in transplant recipients. Rapamycin confers preconditioning-like protection against ischemic-reperfusion injury in isolated mouse heart cultures. Our aim was to further define the role of rapamycin in intracellular Ca^2^+ homeostasis and to investigate the mechanism by which rapamycin protects cardiomyocytes from hypoxic damage. Main methods: We demonstrate here that rapamycin protects rat heart cultures from hypoxic-reoxygenation (H/R) damage, as revealed by assays of lactate dehydrogenase (LDH) and creatine kinase (CK) leakage to the medium, by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-d...

2011-01-01

272

Nano photonic sensors for microdamage detection : an exploratory simulation.

Ion beam induced damage and element loss during a microanalysis of biological tissue

Nano photonic materials are synthetically manufactured crystals at the nano scale with the target of creating a microstructure with a special electro-magnetic periodicity. Such nano photonic materials have the ability to control light propagation and thus are capable of creating photonic bandgaps in the frequency domain. We propose using nano photonic crystals as sensors to detect microdamage in composite materials. We demonstrate using a simulation model that a nano photonic sensor attached to a composite bar experiences a significant change in its bandgap profile when damage is induced in the composite bar. The model predicts the frequency response of the nano photonic sensor using the transfer matrix method. A damage metric to evaluate the change in the frequency response is developed. Successful developments of nano photonic sensors allow damage identification at scales not attainable using current sensing technologies.

2005-04-01

273

Influence of feed water distribution pipe replacement on the water chemistry in the steam generator at Loviisa NPP

Specimen damage and element loss induced by 3 MeV proton and 2 MeV alpha particle bombardment of thin sections of freeze-dried kidney tissue and embedding medium have been studied. Yields of ions scattered from H and C, and characteristic X-rays were measured versus accumulated charge, for curent densities in the range from 8x10{sup -15} to 1.1x10{sup -11} A/{mu}m{sup 2}. Structural damage, dissolouration and loss of S, Cl, C and H have been observed. Implications of this study for ion beam microanalysis of biological tissues are discussed with particular reference to the results for H loss. (orig.).

1991-03-01

274

Implant damage and redistribution of indium in indium-implanted thin silicon-on-insulator

Imatran Voima Oy , (IVO) operates two Russian designed nuclear power plants of type VVER440/213. Unit 1 has been operating since 1977 and unit 2 since 1981. First damage of feed water distribution (FWD) pipes was observed in 1989. In closer examinations FWD-pipe T-connection and distribution nozzles suffered from severe erosion corrosion damage. Similar damages have been found also in other VVER-440 type NPPs. In 1994 the first FWD-pipe was replaced by a new design mounted over the tube bundle instead of the old FWD-pipe, which was located inside the tube bundle. The purpose of this paper is to describe the new FWD-pipe and discuss its effects on the steam generator chemistry. (author)

1998-06-01

275

Implant damage and redistribution of indium in indium-implanted thin silicon-on-insulator

The indium implant damage and diffusion behavior in thin silicon-on-insulator (SOI) with a 200 nm top silicon layer were studied for different implantation energies and doses. Rutherford backscattering spectrometry in the channeling mode (RBS/C) was used to characterize the implant damage before and after annealing. Secondary ion mass spectrometry (SIMS) was used to study the indium transient enhanced diffusion (TED) behavior in the top Si layer of the SOI structure. An anomalous redistribution of indium after relatively high energy (200 keV) and dose (1 x 10{sup 14} cm{sup -2}) implantation was observed in both bulk Si and SOI substrates. However, there exist differences in these two substrates that are attributable to the more predominant out-diffusion of indium as well as the influence of the buried oxide layer in the SOI structure.

2004-12-15

276

Impact of Collateral Damage to Endourologic Tools During Laser Lithotripsy???In Vitro Comparison of Three Different Clinical Laser Systems

The indium implant damage and diffusion behavior in thin silicon-on-insulator (SOI) with a 200 nm top silicon layer were studied for different implantation energies and doses. Rutherford backscattering spectrometry in the channeling mode (RBS/C) was used to characterize the implant damage before and after annealing. Secondary ion mass spectrometry (SIMS) was used to study the indium transient enhanced diffusion (TED) behavior in the top Si layer of the SOI structure. An anomalous redistribution of indium after relatively high energy (200 keV) and dose (1 x 10"1"4 cm"-"2) implantation was observed in both bulk Si and SOI substrates. However, there exist differences in these two substrates that are attributable to the more predominant out-diffusion of indium as well as the influence of the buried oxide layer in the SOI structure.

2004-12-15

277

British Library Electronic Table of Contents (United Kingdom)

Abstract Background and Purpose: During laser lithotripsy, working instruments are often in close proximity to the distal fiber tip and may be damaged accidentally or even intentionally. The aim of this study was to compare the amount of damage to a standard guidewire and the nitinol wires of endourologic retrieval baskets that were affected by three different clinically available laser systems. Materials and Methods: The impact of pulsed laser irradiation on a standard hydrophilic guidewire and a retrieval basket were investigated. One infrared (IR) laser system (holmium:yttrium-aluminum-garnet [Ho:YAG]: ????=???2100???nm) and two laser systems emitting light in the visible (VIS) spectral range (frequency-doubled double-pulse neodymium:YAG [FREDDY]: ????=???532???nm/1064???nm and flashl...

2011-01-01

278

Development of SDT sensor based eddy current probe for detection of deep fatigue cracks in multi-layer structure

British Library Electronic Table of Contents (United Kingdom)

The detection and characterization of deeply buried fatigue damage in thick, multi-layer airframe components pose significant technical challenges to the aviation safety community. Currently, no nondestructive evaluation technique is available to reliably detect such potential damage from the exterior of the airframe, which is highly desirable in light of inspection cost as well as avoidance of structure damage. Recent technological advances in high-sensitivity magnetic sensors, i.e., spin-dependent tunneling (SDT) sensors, make it feasible to employ electromagnetic inspection techniques for deep fatigue crack inspection. In this work, we report on the development and fabrication of a low frequency eddy current probe based on a magnetically shielded SDT pickup sensor concentrically located...

2010-01-01

279

Development and credibility assessment of a metamodel relating water table depth to agricultural production

British Library Electronic Table of Contents (United Kingdom)

Phreatic groundwater pumping is affecting water availability for crops in areas with a shallow water table. This can reduce crop growth and so affect farm income. There is a need for a generic and transparent method to assess the agricultural damage caused by water table drawdown. This paper proposes such a method that consists of 'damage tables' relating agricultural production losses to the groundwater regime for different soil/crop combinations found in Northern Belgium. The damage tables are constructed based on numerous simulations with the agrohydrological model SWAP, in which the bottom boundary conditions are gradually changed to reflect different groundwater regimes. The credibility of the resulting metamodel is assessed in three ways: using (1) field data, (2) an existing local e...

2010-01-01

280

Development and analysis of stage-damage curves for the Kum River basin

Damage mechanisms around hardness indentations in Ti{sub 3}SiC{sub 2}

In the flood surveys, it is fundamental to set up the relations of stage-damage. And this makes it possible to evaluate the flood regulation effects of the multipurpose dam and/or levee construction for optimum formulation. Unfortunately in the previous basin studies excluding the Han river basin survey, the conventional approaches on this matter have not been performed due to its time-consuming complexity. In this study we attempted a new method based on the disaster status, and constructed six stage-damage curves along the reaches of the Kum river basin, based upon the flood events records for recent 12 years (1981-92). (author). 12 refs., 3 tabs., 13 figs.

1996-10-31

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281

Cytokine-induced impairment of short-chain fatty acid oxidation and viability in human colonic epithelial cells

Microstructural observations of damage around indentations in Ti{sub 3}SiC{sub 2} are presented. The Vickers hardness decreased with increasing load and asymptotically approached 4 GPa at the highest loads. No indentation cracks were observed even at loads as high as 300 N. Preliminary strength versus indentation plots indicate that, at least for the large-grained material ({approx}100 {micro}m) studied here, Ti{sub 3}SiC{sub 2} is a damage-tolerant material able to contain the extent of microdamage to a small area around the indent. The following multiple energy-absorbing mechanisms have been identified from scanning electron micrographs of areas in the vicinity of the indentation: diffuse microcracking, delamination, crack deflection, grain push-out, grain pull-out, and the buckling of individual grains.

1997-02-01

282

DEFF Research Database (Denmark)

Pro-inflammatory cytokines may directly influence the viability and metabolic function of colonic epithelial cells (CEC) as an early event in the development of inflammatory bowel disease. We report here that TNF-alpha+IFN-gamma induced a synergistic, concentration-dependent decline in butyrate oxidation, an essential energy supply, in HT-29 and DLD-1 cells. TNF-alpha+IFN-gamma induced a parallel profound decline in cell viability in HT-29 cells, but not in DLD-1 cells, where impairment of butyrate oxidation seemed to precede later occurrence of cell damage. TNF-alpha+INF-gamma induced CEC damage was independent on NO formation and involved the IFN-gamma signalling pathway as well as induction of apoptosis. If cytokines have similar effects in vivo, these may lead to energy deficiency and thus contribute to CEC damage and disturbance of the epithelial integrity.

2000-01-01

283

Characterization of focused-ion-beam-induced damage in n-type silicon using Schottky contact

Channeling studies of radiation damage in metal-silicides

The effects of focused-ion-beam-induced damage on electrical properties of n-type Si are investigated by Schottky contacts. Crystalline Si is exposed to 10-30 keV focused ion beam (FIB), followed by Pt deposition under vacuum of 4x10"-"4 Pa. From current-voltage-temperature measurements, barrier heights of the Schottky contacts are found to increase almost linearly as the FIB energy increases, with the maximum increment of 0.29 eV. The increase is suggested to be related to the arising of acceptorlike defects and an amorphous layer due to FIB damages. A theoretical model is set up to quantitatively describe the barrier height changes.

2006-04-10

284

Channeling studies of radiation damage in metal-silicides

Channeling effect measurements have been employed to investigate radiation damage produced by 100-keV Ar ions in preferred oriented polycrystalline metal-silicide layers, such as Pd/sub 2/Si and NiSi/sub 2/ layers formed on single-crystalline Si. For room-temperature implantation, an amount of the damage in Pd/sub 2/Si layers was found to saturate at doses between 3 x 10/sup 14/ and 1 x 10/sup 17/ ions/cm/sup 2/, where the minimum aligned yield of 1.5-MeV He ions was nearly 40% of the random one. On the contrary, it was observed that the NiSi/sub 2/ layers became amorphous at doses higher than 3 x 10/sup 15/ ions/cm/sup 2/. These results were confirmed by the reflection electron diffraction analyses.

1978-01-01

285

Atomic scale simulations of arsenic ion implantation and annealing in silicon

Channeling effect measurements have been employed to investigate radiation damage produced by 100-keV Ar ions in preferred oriented polycrystalline metal-silicide layers, such as Pd_2Si and NiSi_2 layers formed on single-crystalline Si. For room-temperature implantation, an amount of the damage in Pd_2Si layers was found to saturate at doses between 3 x 10"1"4 and 1 x 10"1"7 ions/cm"2, where the minimum aligned yield of 1.5-MeV He ions was nearly 40% of the random one. On the contrary, it was observed that the NiSi_2 layers became amorphous at doses higher than 3 x 10"1"5 ions/cm"2. These results were confirmed by the reflection electron diffraction analyses.

286

Analysis of deteriorating processes in primary circuit facilities and determination of their priorities and relevance to the lifetime of the main primary circuit components

We present results of multiple-time-scale simulations of 5, 10 and 15 keV low temperature ion implantation of arsenic on silicon (100), followed by high temperature anneals. The simulations start with a molecular dynamics (MD) calculation of the primary state of damage after 10ps. The results are then coupled to a kinetic Monte Carlo (MC) simulation of bulk defect diffusion and clustering. Dose accumulation is achieved considering that at low temperatures the damage produced in the lattice is stable. After the desired dose is accumulated, the system is annealed at 800 degrees C for several seconds. The results provide information on the evolution for the damage microstructure over macroscopic length and time scales and affords direct comparison to experimental results. We discuss the database of inputs to the MC model and how it affects the diffusion process.

2004-12-15

287

"9"9"mTechnetium-heat damaged erythrocyte spleen scan

The major degradation mechanisms acting during the aging of selected WWER-440/213 primary circuit facilities were assessed critically. The analysis gave evidence that such mechanisms include radiation and fatigue damage of the reactor pressure vessel (effect of the neutron flow, cyclic fatigue promoted by the corrosive medium, effect of thermal aging), corrosion-mechanical and thermo-mechanical (fatigue) damage of the steam generator (stress corrosion cracking, erosion corrosion, thermal aging, wear), thermal and dynamic aging of the pressurizer, and corrosion-mechanical damage of the primary circuit piping (thermal aging, corrosion). (J.B.). 5 tabs., 1 fig., 62 refs.

288

Swimming exercise training prior to acute myocardial infarction attenuates left ventricular remodeling and improves left ventricular function in rats.

"9"9"mTechnetium -heat damaged erythrocyte were used as spleen scanning agents in 12 patients from July, 1985 to April, 1986. We used this scan to evaluate situs inversus, asplenia, accessory spleen, hypersplenism, splenic infarction, tumor staging and evaluation of therapy, especially when the "9"9"mTc-tin colloid scans were not definite for diagnosis. The techniques applied to these scans were in vivo/in vitro-labeling method and heating-method to damage the erythrocytes. Liver-to-spleen uptake ratios were increased upto 100:1 and interference from the left lobe of the liver was eliminated. These scans were helpful to evaluate the spleen. (Author).

289

Effects of exogenous norepinephrine on the spatial distribution of cardiac MIBG accumulation. Comparison with myocardial blood flow

The effect of exercise training prior to acute myocardial infarction (AMI) on left ventricular (LV) remodeling is poorly understood. This study investigated the protective effect of 3 weeks of swimming exercise training prior to AMI on cardiac morphology and function. Male Sprague-Dawley rats (n = 35) were randomly assigned to 3 groups: swimming training (n = 14, 90 min, 5 days/wk, 3 wk), sedentary (n =14), and controls (n = 7, no exercise, no MI). At the end of the training/sedentary period, rats were subjected to AMI (ExMI and SedMI) induced by surgical ligation of the left coronary artery. Thereafter, the rats remained sedentary for a 4-wk recovery period. Trans-thoracic echocardiography was performed in each group at the end of the exercise/sedentary period (pre-AMI), 24 hr after AMI, and following recovery (4 wk after AMI). No differences were observed in LV dimensions and function pre-AMI among the 3 groups; however, LV-end systolic diameter (LVESD) and ...

2005-01-01

290

Abnormal cardiovascular responses induced by localized high power microwave exposure

Male rats were injected intravenously for 15 min with physiological saline (as control) (0.05 #mu#g/kg/min) or norepinephrine (NE) (0.1 #mu#g/kg/min) followed by 740 kBq of MIBG. Rats were injected for more 30 min (early stage group) and for more 4 hr (late stage group) with physiological saline or NE. Five MBq of "9"9"mTc-tetrofosmin (TF) was administered instead of MIBG in another group. The heart was isolated and uptake of MIBG or TF of right ventricle, apex, and left ventricle (divided into 8 parts) was measured. In control group, MIBG uptake of apex was significantly lower than that of lateral wall in both early and late groups. In NE group, MIBG uptake showed a tendency to decrease in both early and late groups. Compared with control group, the uptake of anterior wall in late group decreased significantly at NE 0.1 #mu#/kg/min. The TF uptake in control group was not different in each part. In NE group, the TF uptake of right ventricle decreased significantly compared with that of ...

1998-06-01

291

X-ray dose enhancement effects

A hypothesis of microwave-induced circulatory under perfusion was tested in ketamine anesthetized rats whose heart rate, mean arterial pressure, pulse pressure, respiration rate, and body temperatures were monitored continuously. Fifty-eight ventral head and neck exposures in a waveguide consisted of sham-exposure and exposure to continuous wave (CW) and pulsed 1.25 GHz microwaves for 5 min. The 0.5 Hz and 16 Hz pulsemodulated microwaves were delivered at 400 kW peak power. The CW microwaves were 2 and 6.4 W. The average specific absorption rate was 4.75 W/kg per watt transmitted in the brain and 17.15 W/kg per watt transmitted in the neck. Respiration rate and mean arterial pressure were not altered. Changes in heart rate and pulse pressure were observed in rats exposed to higher power but not to the lower average power microwaves. Depression of pulse pressure, an indication of a decrease in stroke volume, and increased or decreased heart rate were noted in presence of whole-body ...

1992-05-01

292

Vitamin C and E Supplementation Effects in Professional Soccer Players Under Regular Training

A brief description of the physical process of dose enhancement effects produced by X-ray radiation on materials is given, with emphasis on the influence on electronic devices. The damages caused by X-ray radiation dose enhancement is more serious than that of #gamma#-ray with higher energy.

293

Use of clopidogrel in the reduction of myocardial damage during percutaneous coronary intervention

Exercise training is known to induce an increase in free radical production potentially leading to enhanced muscle injury. Vitamins C and E are well known antioxidants that may prevent muscle cell damage....Full Text Available

294

Uracil DNA glycosylase uses DNA hopping and short-range sliding to trap extrahelical uracils

It is estimated that approximately a quarter of patients undergoing coronary intervention may have significant post-procedural creatinine (CK)/creatinine kinase myocardial band (CK-MB) elevations and...Full Text Available

2009-01-01

295

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

The astonishingly efficient location and excision of damaged DNA bases by DNA repair glycosylases is an especially intriguing problem in biology. One example is the enzyme uracil DNA glycosylase (UNG),...Full Text Available

2008-08-05

296

Unusual occurrence of accessory central cusp in the maxillary second primary molar

The oxidative stress theory of aging predicts that manipulations that alter oxidative stress/damage will alter aging. The gold standard for determining whether aging is altered is lifespan,...Full Text Available

2010-03-01

297

Tool Life Prediction for Ceramic Tools in Intermittent Turning of Hardened Steel Based on Damage Evolution Model

Accessory cusp present on the occlusal surface may seldom pose problems. While its presence may not be a cause for alarm in most instances, it can sometimes lead to serious consequences if it is damaged....Full Text Available

2011-04-01

298

Thin Film Solar Cells and Solar Cell Testing, Volume II Proceedings of the Fourth Photovoltaic Specialists Conference

Al2O3-based ceramic is one of the most widely used materials for tools employed in hardened steel turning applications due to its high hardness, wear resistance, heat resistance and chemical stability. The objective of this work is to predict the lives of Al2O3-(W, Ti)C ceramic tools in intermittent turning of hardened AISI 1045 steel by means of damage evolution model taking into account the mechanical loading and thermal effect in the cutting process. A damage evolution model analyzing the RVE with uniformly distributed interacting cracks is constructed based on micromechanics. The calculated results of the proposed damage evolution model are compared with the lives of two kinds of Al2O3-(W, Ti)C ceramic tools obtained through experiments. It is found that the proposed model can be used to predict the lives of the ceramic cutting tools in intermittent turning operation.

2011-07-01

299

The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damage

Thin film solar cells and solar cell testing - photovoltaic cells, radiation damage to cadmium sulfide solar cells, and airplane testing of solar cells

1964-01-01

300

The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome

DNA double-strand breaks (DSBs) and other lesions occur frequently during cell growth and in meiosis. These are often repaired by homologous recombination (HR). HR may result in the formation of DNA...Full Text Available

2011-09-01

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301

The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms

FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluorodeoxyuridine (FdU) that affect intracellular thymidylate levels. FRAXA coincides with a >200...Full Text Available

2009-07-01

302

The oncogenic transforming potential of the passage of single ? particles through mammalian cell nuclei

Reactive oxygen species (ROS), inevitable byproducts of aerobic metabolism, are known to cause oxidative damage to cells and molecules. This, in turn, is widely accepted as a pivotal determinant of...Full Text Available

2008-09-01

303

The Oxazolidinone Derivative Locostatin Induces Cytokine Appeasement1

Domestic, low-level exposure to radon gas is considered a major environmental lung-cancer hazard involving DNA damage to bronchial cells by α particles from radon progeny. At domestic exposure...Full Text Available

1999-01-05

304

Successful Treatment of Anterior Tracheal Necrosis after Total Thyroidectomy Using Vacuum-Assisted Closure Therapy

Damaging inflammation arising from autoimmune pathology and septic responses results in severe cases of disease. In both instances, anti-inflammatory compounds are used to limit the excessive...Full Text Available

2009-12-01

305

Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells

Total thyroidectomy involving the adjacent structures of the trachea can cause tracheal damage such as early tracheal necrosis. The authors describe the first case of anterior tracheal necrosis following...Full Text Available

2012-01-01

306

Study on the transient piping vibration of power plant. Secondary piping system of Wolsung 1 unit.

4-Hydroxynonenal (HNE), a major electrophilic product of lipid peroxidation, is regarded as both a marker of oxidative stress and a mediator of oxidative damage. At subtoxic concentrations,...Full Text Available

2007-01-01

307

Simultaneous Reactivation of Ultraviolet Damage in Xanthium Leaves ¹

In order to maintain a safe operation and availability of generating facilities, qualitative and quantitative assessment of piping vibration was performed vibration sources and damages of piping support was identified on the second piping system of Wolsun...

1996-01-01

308

Satellite imagery in the study and forecast of malaria

Experiments on Xanthium leaf discs were carried out to determine whether concomitant photoreactivation could be detected and if so, to compare its effects with photoreactivation due...Full Text Available

1969-12-01

309

SBIR 98-I Awards by Topic - NASA's SBIR & STTR Programs

More than 30 years ago, human beings looked back from the Moon to see the magnificent spectacle of Earth-rise. The technology that put us into space has since been used to assess the damage...Full Text Available

2002-02-07

310

Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage

... NC 27605 Winnie Liao (919) 821-5950 98-1-02.01-5950 LaRC Design of Damage- Tolerant Composite Sandwich Panels with Tear Straps American Technology ...

311

Revised neutron dosimetry results for the MOTA-2A experiment in FFTF

Acetaminophen (N-acetyl-para-aminophenol (APAP), paracetamol) is a commonly used analgesic and antipyretic agent. Although considered safe at therapeutic doses, accidental or intentional...Full Text Available

2011-06-01

312

Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage.

Revised neutron fluence and damage values are reported for the MOTA-2A experiment in the Fast Flux Test Facility (FFTF). This revision corrects an error with processing of the {sup 235}U(n,f) reaction. Net corrections are on the order of 5%.

1994-09-01

313

Radiation exposure due to X-rays of the hip joint in babies

Using plasma glutathione S-transferase measurements hepatocellular integrity was assessed in groups of hyperthyroid and hypothyroid patients before and after treatment. Ten of 14 hyperthyroid patients...Full Text Available

1985-08-17

314

RADC RELIABILITY PHYSICS NOTEBOOK

Exact anatomic knowledge about the location of the gonads and the application of corresponding measures of radiation protection are the preconditions for an efficient reduction of the danger of a possible genetic damage as a result of radiation exposition during X-ray examination of the hip joint of newborns. (VJ).

315

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

... 2-37 2.3.1.5.4 Imperfect Bonding of Die ..... 2-37 2.3.1.5.5 "Purple Plague" .... 2-37 2.3.1.5.6 Tool Damage ..... 2-37 ...

1965-10-01

316

Protein Damage by Reactive Electrophiles: Targets and Consequences

The widely accepted oxidative stress theory of aging postulates that aging results from accumulation of oxidative damage. Surprisingly, data from the longest-living rodent known, naked mole-rats [MRs;...Full Text Available

2009-03-03

317

Print sec333photoindex (256 pages)

It has been sixty years since the Millers first described the covalent binding of carcinogens to tissue proteins. Protein covalent binding was gradually overshadowed by the emergence of DNA...Full Text Available

2008-01-01

318

Primary gonadal damage following treatment of brain tumors in childhood

Electro-Magnet. Antenna Panels Types Simulated Hail Stone Damage A.Panel ...... X-Band Klystron Electro Magnet. 11. I I. 333-6104 AcBc. 333-6105 Color ...

319

On the water-chemical regime in steam generators at NPP

Gonadal function was studied in two groups of children previously treated for medulloblastoma with surgery followed by postoperative craniospinal irradiation. In group 1 but not in group 2, the children also received adjuvant chemotherapy for one to two years. All children in group 1 received a nitrosourea (BCNU or CCNU), plus vincristine in four and procarbazine in three patients. The nine children in group 1 showed clinical and biochemical evidence of gonadal damage with elevated serum FSH concentrations and, in the boys, small testes for their stage of pubertal development. In group 2 (n . 8), each child had completed pubertal development normally, the boys had adult sized testes and the girls regular menses. Gonadotropin values were normal in all eight children. We conclude that nitrosoureas were responsible for the gonadal damage in the children in group 1, with procarbazine also contributing to the damage in the three ...

1983-10-01

320

British Library Electronic Table of Contents (United Kingdom)

The effect of the water-chemical regime (WCR) on damage sustained by heating surfaces of steam generators at NPP is analyzed. It is indicated that phosphate treatment with minimal excesses of phosphates in the steamgenerator water is the most optimal method of managing the WCR regime of horizontal steam generators.

2006-01-01

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321

Oil Leak from Damaged Well in Gulf of ... - NASA Earth Observatory

NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract

Apr 25, 2010... oil per day were leaking from an oil well in the Gulf of Mexico in late April, following an explosion at an offshore drilling rig on April 20, 2010. ...

322

Muscle satellite cell proliferation and association: new insights from myofiber time-lapse imaging

BackgroundWe have previously reported that low concentrations of cigarette smoke extract induce DNA damage without leading to apoptosis or necrosis in human bronchial epithelial...Full Text Available

2008-01-01

323

Modeling of the induced damage in argilites. Interaction between civil-engineering barrier and geologic barrier; Modelisation de l'endommagement induit dans les argilites. Interraction entre barriere ouvragee et barriere geologique

BackgroundAs the resident stem cells of skeletal muscle, satellite cells are activated by extracellular cues associated with local damage. Once activated, satellite cells will re-enter...Full Text Available

324

Modeling of the desaturation process in the Eastern argilites taking into account the induced damage; Modelisation du processus de desaturation dans les argilites de l'Est en tenant compte de l'endommagement induit

No abstract prepared.

1999-12-01

325

Mitochondrial DNA haplogroups in early-onset Alzheimer's disease and frontotemporal lobar degeneration

No abstract prepared.

1999-12-01

326

Mitochondrial DNA Damage and Animal Longevity: Insights from Comparative Studies

BackgroundMitochondrial dysfunction, oxidative damage and the accumulation of somatic mutations in mitochondrial DNA (mtDNA) have been associated with certain neurodegenerative disorders....Full Text Available

327

Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses

Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. However, uncontrolled and potentially deleterious endogenous reactions occur,...Full Text Available

328

Measurements of accurate x-ray scattering data of protein solutions using small stationary sample cells

Hepatic damage occurs in males and ovariectomized (OVX), not in proestrus (PE), females following trauma-hemorrhage (T-H). The mechanism responsible for hepatoprotection remains unknown. We hypothesized...Full Text Available

2009-06-01

329

Lack of adequate sun protection for children with oculocutaneous albinism in South Africa

In this paper, we report a method of precise in situ x-ray scattering measurements on protein solutions using small stationary sample cells. Although reduction in the radiation damage...Full Text Available

2009-01-01

330

Irradiation damage in superconductors

BackgroundChildhood is a high risk time for ultraviolet induced skin damage as this age group has more time and opportunity to be outdoors in the sun. Children in Africa with the...Full Text Available

331

Increased Production and Expression of Tissue Thromboplastin-Like Procoagulant Activity In Vitro by Allogeneically Stimulated Human Leukocytes

Most superconductors are quite sensitive to irradiation defects. Critical temperatures may be depressed, critical currents may be increased, by irradiation, but other behaviours may be encountered. In compounds, the sublattice in which defects are created is of significant importance. 24 refs.

1989-05-08

332

In vivo cartilage contact strains in patients with lateral ankle instability

Intravascular coagulation, thrombosis, and fibrin deposition often produce tissue damage in allogeneic inflammatory reactions such as allograft rejection. The mechanisms which initiate blood clotting...Full Text Available

1978-09-01

333

Implantation damage and anomalous diffusion of implanted boron in silicon through SiO_2 films

Damage to the anterior talofibular ligament (ATFL) and cacaneofibular ligament (CFL) during ankle sprain may be linked to the development of osteoarthritis. Altered tibiotalar kinematics have...Full Text Available

2010-09-17

334

Implantation damage and anomalous diffusion of implanted boron in silicon through SiO[sub 2] films

Boron is implanted in crystalline silicon through oxide layers with different thicknesses. The implantation is carried out at various doses and energies of interest in ultra large scale integration (ULSI) application. Rapid thermal annealings (RTA) are used to obtain shallow junctions and electrical activation of the B atoms. However, transient enhanced diffusion induced by implantation damage can be observed. The boron concentration profiles before and after annealing are obtained with secondary ion mass spectrometry (SIMS). It is found that the diffusion transient in the tail region of the boron profile increases with decreasing oxide thickness. Even more, if the implantation damage concerns mostly the oxide, i.e. when the concentration peak is located in this oxide, the oxygen knocked into the silicon substrate could play this way an important role in restricting the boron diffusion, which is good to obtain very shallow junctions. On the ...

335

Identification of novel DNA repair proteins via primary sequence, secondary structure, and homology

Boron is implanted in crystalline silicon through oxide layers with different thicknesses. The implantation is carried out at various doses and energies of interest in ultra large scale integration (ULSI) application. Rapid thermal annealings (RTA) are used to obtain shallow junctions and electrical activation of the B atoms. However, transient enhanced diffusion induced by implantation damage can be observed. The boron concentration profiles before and after annealing are obtained with secondary ion mass spectrometry (SIMS). It is found that the diffusion transient in the tail region of the boron profile increases with decreasing oxide thickness. Even more, if the implantation damage concerns mostly the oxide, i.e. when the concentration peak is located in this oxide, the oxygen knocked into the silicon substrate could play this way an important role in restricting the boron diffusion, which is good to obtain very shallow junctions. On the ...

1993-07-16

336

High temperature fatigue damage in three austenitic alloys

BackgroundDNA repair is the general term for the collection of critical mechanisms which repair many forms of DNA damage such as methylation or ionizing radiation. DNA repair has...Full Text Available

337

Heat Stress and Hormetin-Induced Hormesis in Human Cells: Effects on Aging, Wound Healing, Angiogenesis, and Differentiation

A series of cyclic strain controlled tests have been carried out at 600/sup 0/C on three high temperature austenitic iron-based alloys, AISI type 316 stainless steel, Alloy 800 H and Sandvik 253 MA. The tests were carried out under constant total strain control using a constant strain rate of 0.005 s/sup -1/. By considering the changes in modulus throughout the life of each specimen it was found that damage evolution could be successfully predicted as a function of plastic strain range despite the fact that each alloy had been chosen because of a different stress response at 600/sup 0/C. Although each alloy accumulated fatigue damage in a similar manner the longer lives of Sandvik 253 MA and Alloy 800 H at a given total strain range were due to a smaller plastic strain component and a reduced stage I crack propagation rate. In the 253 MA alloy, slip was predominantly planar with some cells occasionally forming at high strain ranges. Slip was ...

1988-01-01

338

Glycyrrhizin as antiviral agent against Hepatitis C Virus

Accumulation of molecular damage and increased molecular heterogeneity are hallmarks of cellular aging. Mild stress-induced hormesis can be an effective way for reducing the accumulation of molecular...Full Text Available

339

Generation and control of sound bullets with a nonlinear acoustic lens

BackgroundHepatitis C virus is a major cause of chronic liver diseases which can lead to permanent liver damage, hepatocellular carcinoma and death. The presently available treatment...Full Text Available

340

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

Acoustic lenses are employed in a variety of applications, from biomedical imaging and surgery to defense systems and damage detection in materials. Focused acoustic signals, for example, enable ultrasonic...Full Text Available

2010-04-20

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341

Emergent magnetic moments produced by self-damage in plutonium

Silent information regulators are potent NAD⁺-dependent protein deacetylases, which have been shown to regulate gene silencing, muscle differentiation and DNA damage repair. Here,...Full Text Available

2010-01-01

342

Embryonic anti-aging niche

Plutonium possesses the most complicated phase diagram in the periodic table, driven by the complexities of overlapping 5f electron orbitals. Despite the importance of the 5f...Full Text Available

2006-11-14

343

Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes

Although functional organ stem cells persist in the old, tissue damage invariably overwhelms tissue repair, ultimately causing the demise of an organism. The poor performance of stem cells in an aged...Full Text Available

344

Developmental alcohol exposure disrupts circadian regulation of BDNF in the rat suprachiasmatic nucleus

IntroductionRadiotherapy outcomes might be further improved by a greater understanding of the individual variations in normal tissue reactions that determine tolerance. Most published...Full Text Available

2005-01-01

345

Design of Composite Structures for Reliability and Damage Tolerance.

In rats, damage to neuronal populations in some brain regions occurs in response to neonatal alcohol exposure coinciding with the period of rapid brain growth. These alcohol-induced defects...Full Text Available

2004-01-01

346

Cracking resistance in steam pipe fittings having various microdamage levels

A summary of research conducted during the first year is presented. The research objectives were sought by conducting two tasks: (1) investigation of probabilistic design techniques for reliability-based design of composite sandwich panels, and (2) examin...

1999-01-01

347

Corrosion failure and its prevention in light water reactor power plants

Cracking resistance and metal damage are considered in relation to structural state for steam-pipe fittings during use. An approximate scheme is given for estimating the maximum permissible operating time in the plastic state in relation to the depth of an observed crack-type defect.

1995-05-01

348

Corrosion failure and its prevention in light water reactor power plants

During 17 years since the start of operation of the first commercial LWR in Japan, many LWRs have experienced various corrosion damages, but the causes of them were clarified, and the counter-measures were executed effectively in actual plants, as the results, the cause of corrosion damage decreased remarkably, and now, the high rate of operation has become to be maintained. In this paper, the major cases of corrosion damage experienced in LWRs in Japan and foreign countries, the causes of them and the countermeasures, the problems of hereafter and so on are described. The corrosion damage of metallic materials in the environment of LWRs occurs in the parts in contact with high temperature, high pressure water and steam, such as stainless steel piping in the primary cooling system of BWRs, and nickel alloy heating tubes of steam generators, carbon steel feed water piping and zirconium alloy fuel ...

1988-01-01

349

Cocaine induces cell death and activates the transcription nuclear factor kappa-b in pc12 cells

During 17 years since the start of operation of the first commercial LWR in Japan, many LWRs have experienced various corrosion damages, but the causes of them were clarified, and the counter-measures were executed effectively in actual plants, as the results, the cause of corrosion damage decreased remarkably, and now, the high rate of operation has become to be maintained. In this paper, the major cases of corrosion damage experienced in LWRs in Japan and foreign countries, the causes of them and the countermeasures, the problems of hereafter and so on are described. The corrosion damage of metallic materials in the environment of LWRs occurs in the parts in contact with high temperature, high pressure water and steam, such as stainless steel piping in the primary cooling system of BWRs, and nickel alloy heating tubes of steam generators, carbon steel feed water piping and zirconium alloy fuel ...

350

CXCL12-Mediated Guidance of Migrating Embryonic Stem Cell-Derived Neural Progenitors Transplanted into the Hippocampus

Cocaine is a worldwide used drug and its abuse is associated with physical, psychiatric and social problems. The mechanism by which cocaine causes neurological damage is very complex and involves several...Full Text Available

351

CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage

Stem cell therapies for neurodegenerative disorders require accurate delivery of the transplanted cells to the sites of damage. Numerous studies have established that fluid injections to the hippocampus...Full Text Available

352

Atmospheric corrosion in Gran Canaria specifically meteorological and pollution conditions.

The antitumor agent camptothecin targets DNA topoisomerase I by reversibly stabilizing a covalent enzyme-DNA intermediate. The subsequent collision of DNA replication forks with these drug-enzyme-DNA...Full Text Available

1999-09-28

353

Antioxidant enzyme activities are not broadly correlated with longevity in 14 vertebrate endotherm species

Carbon steel, copper, zinc and aluminium samples were exposed in different sizes with known ambient parameters in Gran Canaria Island and atmospheric corrosion was investigated. Weight-loss measurements used to determine corrosion damage were complemented...

1998-01-01

354

Antioxidant Defenses Predict Long-Term Survival in a Passerine Bird

The free radical theory of ageing posits that accrual of oxidative damage underlies the increased cellular, tissue and organ dysfunction and failure associated with advanced age. In support of this...Full Text Available

2010-06-01

355

Analysis on the alterations of lens proteins by Vitex negundo in selenite cataract models

BackgroundNormal and pathological processes entail the production of oxidative substances that can damage biological molecules and harm physiological functions. Organisms have evolved...Full Text Available

356

An ounce of prevention or a pound of cure: bioeconomic risk analysis of invasive species.

PurposeCataract is the leading cause of blindness and is associated with oxidative damage and protein modification in the lens. In the present study, we have employed proteomic and...Full Text Available

357

Air pollution induces heritable DNA mutations

Numbers of non-indigenous species--species introduced from elsewhere - are increasing rapidly worldwide, causing both environmental and economic damage. Rigorous quantitative risk-analysis frameworks,...Full Text Available

2002-12-07

358

Advanced nuclear data for radiation-damage calculations

Hundreds of thousands of people worldwide live or work in close proximity to steel mills. Integrated steel production generates chemical pollution containing compounds that can induce genetic damage...Full Text Available

2002-12-10

359

Aberrant repair and fibrosis development in skeletal muscle

Accurate calculations of atomic displacement damage in materials exposed to neutrons require detailed spectra for primary recoil nuclei. Such data are not available from direct experimental measurements. Moreover, they cannot always be computed accurately starting from evaluated nuclear data libraries such as ENDF/B-V that were developed primarily for neutron transport applications, because these libraries lack detailed energy-and-angle distributions for outgoing charged particles. Fortunately, a new generation of nuclear model codes is now available that can be used to fill in the missing spectra. One example is the preequilibrium statistical-model code GNASH. For heating and damage applications, a supplementary code called RECOIL has been developed. RECOIL uses detailed reaction data from GNASH, together with angular distributions based on Kalbach-Mann systematics to compute the energy and angle distributions of recoil nuclei. The ...

1983-01-01

360

ATM-Dependent Phosphorylation of ATF2 Is Required for the DNA Damage Response

The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells...Full Text Available

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361

46 CFR 160.171-17 - Approval testing for adult size immersion suit.

SummaryActivating transcription factor 2 (ATF2) is regulated by JNK/p38 in response to stress. Here, we demonstrate that the protein kinase ATM phosphorylates ATF2 on serines...Full Text Available

2005-05-27

362

Using focused ion beam damage patterns to photoelectrochemically etch features in III-V materials

...visible damage. (k) Corrosion resistance. Each metal part of a...evidence of salt-spray corrosion resistance equal to or greater than...sample of test metal must show corrosion resistance equal to or better than...

2010-10-01

363

Threats to ICF reactor materials: computational simulations of radiation damage induced topological changes in fused silica

A method of patterning n-type GaAs, InP, InGaAs, and InGaAsP by photoelectrochemical (PEC) etching in conjunction with a submicron focused ion beam (FIB) at low dose is described. The ion beam is used to produce damage in a desired pattern in the material. Subsequent PEC etching of the material reveals the ion induced features in relief. The procedure is highly sensitive, requiring a dose of only 5 x 10/sup 9/ ions/cm/sup 2/ for the differential etch to become apparent. The sensitivity allows rapid pattern generation in our FIB system.

1986-03-10

364

Repair welding of a low pressure runner with cracks; Reparaturschweissung eines rissbehafteten Niederdrucklaeufers

We have performed molecular dynamics simulations of radiation damage in fused silica. In this study, we discuss the role of successive cascade overlap on the saturation and self-healing of oxygen vacancy defects in the amorphous fused silica network. Furthermore, we present findings on the topological changes in fused silica due to repeated energetic recoil atoms. These topological network modifications consistent with experimental Raman spectroscopic observation on neutron and ion irradiated fused silica are indicators of permanent densification that has also been observed experimentally.

2003-04-01

365

Priority rankings of the system modifications to reduce core damage frequency of Wolsong NPP units 2/3/4

In the power station West Block 2 at Voerde (Federal Republic of Germany), cracks in the final stage of the shaft were determined at the ND1 rotor of the 350 MW condensation tube was determined. A purely mechanical preparation of the crack was not possible due to the depth of the crack. A substitute rotor was not available. A repair solution was developed covering a welding of a new shaft section to the existing rotor. The authors of the contribution under consideration report on the damage, cause of the damage, repair solution and the process of repair.

2010-07-01

366

Modeling Blast and High-Velocity Impact of Composite Sandwich Panels

The analysis for priority rankings of the recommendations to reduce the total core damage frequency (CDF) of Wolsong nuclear power plant units 2/3/4 was performed in this paper. In order to derive the recommendations, the sensitivity analysis of CDF on which major contributors effect was performed based on the accident quantification results during Level 1 probabilistic safety assessments (PSA). Priorities were ranked in the way that compares the CDF reduction rate with the efforts required to implement those recommendations using risk matrix.

1998-05-01

367

Low temperature proton irradiation of amorphous Pd/sub 80/Si/sub 20/ prepared by ion implantation

Analytical models for predicting the deformation and failure of composite sandwich panels subjected to blast and projectile impact loading are presented in this paper. The analytical predictions of the transient deformations and damage initiation in the composite sandwich panels were compared with finite element solutions using ABAQUS Explicit. For the blast model, the predicted transient deformation of the sandwich panel was within 7%of FEA results, while the predicted damage initiation using Hashin's composite failure criteria was about 15%higher than FEA results in most cases. For the high velocity impact model, the predicted transient deformations were within 20%of FEA results.

2009-01-01

368

Life management of power plant based on structural damage testing

The damage induced by low-temperature proton irradiation in amorphous Pd/sub 80/Si/sub 20/ prepared by ion implantation is studied via electrical resistivity measurements. Our experimental results concerning the initial damage rate and the resistivity saturation are compared to the results obtained for electron and high energy /sup 16/O irradiation of amorphous Pd/sub 80/Si/sub 20/ quenched from the melt. The resistivity curve is analyzed in terms of irradiation-induced point defects.

1984-05-01

369

Helium atom doping of molybdenum and its influence on the radiation hardenings

Life management system is based on the valid nowadays in Estonian power plants regulation documentation. The system allows to estimate stress distribution in components, find computational assessment of cumulated creep damage, determine when and where it is necessary to cut off the particular number of microsamples or take replicas. Finally, the real metal condition may be assessed on the basis of metallographic specimen research and reasonable 3-R decision - run, repair, replacement - made on further component use. (orig.) 6 refs.

1998-12-31

370

Damages at industry steam turbines; Schaeden an Industriedampfturbinen

Experimental results on study of helium concentration influence on degree of molybdenum radiation hardening for various method of cyclotron doping differing in degree and damage character are presented. It is established that accumulation of helium atoms in molybdenum for simultaneous formation of radiation defects caused by low energetic primary-knocked atoms leads to higher degree of hardening than for high energetic ion irradiation. It is shown that with increase of helium atom concentration the degree of radiation hardening for the same level of damage increases. 4 refs.; 3 figs. (author).

1990-05-22

371

The operation of steam turbines is technically controllable. The manufacturers specify reliable operating ranges as well as demands on the implementation of steam turbines into the power plant process for the respective steam turbines. The VGB guidelines describe the generally valid procedures for the operation of steam turbines in detail. Important insights at some steam turbines are not or only insufficiently converted nevertheless. Damage and extended downtimes at revisions are the result. The author of the contribution under consideration describes some more and more occurring problems. Recommendations and suggestions are given with respect to the avoidance of such findings.

2010-07-01

372

Cost of oil spills

BURST STRENGTH AND NON-DESTRUCTIVE EVALUTION OF COMPOSITE PIPES AND PIPE COUPLINGS WITH DEFECTS (TOP 48)

A collection of 14 papers from a June 1981 seminar assess the costs of damage caused by water pollution. The seminar focused on the economic rather than the legal standpoint by evaluating the cost of the clean-up operations themselves and other costs, such as direct or indirect economic losses, and converting into money terms the damage to the environment, the loss of recreational facilities, and biomass losses. The papers are grouped into four sections which look at the scale of risk, the clean-up costs for specific oil spills, other costs inflicted on coastal zones, and legal aspects of compensation. Separate abstracts were prepared for each of the 16 papers selected for the Energy Data Base.

1982-01-01

373

Environmental Research Database

ObjectivesObjectives Not AvailableDescriptionTo determine the effects of water penetration on the burst strength of filament wound composite pipes which have been damaged by impact and then subjected to long term pressurisation with sea water. ~%~ To monitor and characterise the damage and effects of sea water penetration using ultrasonic NDT. To determine the burst strength of bonded composite pipe joints with and without defects and to see whether the defects can be detected using ultrasonic NDT. [continued...

1996-01-31

374

Atmospheric corrosion in Gran Canaria specifically meteorological and pollution conditions

Study of proton therapy on malignant tumors. Effects in twenty-four hours after proton irradiation

Carbon steel, copper, zinc and aluminium samples were exposed in different sizes with known ambient parameters in Gran Canaria Island and atmospheric corrosion was investigated. Weight-loss measurements used to determine corrosion damage were complemented with metallographic and XP S determination in order to characterize the structure and morphology of surface corrosion products. The ambient aggressiveness could be well evaluated from meteorological and pollution data. All atmospheric corrosion and environmental data were statistically processed for establishing general corrosion damage functions for carbon steel, copper, aluminium and zinc in terms of Gran Canaria extreme meteorological and pollution parameters. (Author)

1998-12-31

375

ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB

We irradiated proton beams on the ears of rabbits and the Harding-Passey mouse melanoma and observed their morphological change. We used 52 MeV proton beams from the INS-FM cyclotron. We adjusted the energy of the proton beams to be at the plateau part of the Bragg curve, at the half-way point of the Bragg peak, and at the Bragg peak. The amount of radiation was 5000rad in each case. The Harding-Passey mouse melanoma was transplanted into the subcutan of a three week old mouse. In this experiment, we used tumors, the diameter of which grew up to 1.5-2cm in 2-3 weeks after the transplantation. Using the jroscope, we observed both lightly and severely damaged cells. Using proton irradiation with the Bragg peak located at depth of 1mm in the rabbit's ears, we studied the change in the tissue. Irradiated epidermis fell off and was eroded because of radiation damage, but the rear surface of the rabbit's ears was only slightly ...

1983-01-01

376

{sup 99m}TC tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left ventricular dysfunction; Tomografia cardiaca {sup 99m}Tc tetrofosmina dopo somministrazione di nitrati in pazienti con cardiopatia ischemica e disfunzione ventricolare sinistra

The helicase action of the Escherichia coli UvrAB complex on a covalently closed circular DNA template was monitored using bacterial DNA topoisomerase I, which specifically removes negative supercoils. In the presence of E. coli DNA topoisomerase I and ATP, the UvrAB complex gradually introduced positive supercoils into the input relaxed plasmid DNA template. Positive supercoils were not produced when E. coli DNA topoisomerase I was replaced by eukaryotic DNA topoisomerase I or when both E. coli and eukaryotic DNA topoisomerases I were added simultaneously. These results suggest that like other DNA helix-tracking processes, the ATP-dependent action of the UvrAM complex on duplex DNA simultaneously generates both positive and negative supercoils, which are not constrained by protein binding but are torsionally strained. The supercoiling activity of UvrAB on UV-damaged DNA was also studied using UV-damaged plasmid DNA and a mutant UvrA protein ...

377

The effect of swimming exercise on spontaneous ventricular defibrillation and ventricular fibrillation threshold in the isolated perfused rat heart.

The work examines twenty-two patients with coronary artery disease, previous myocardial infarction and LV dysfunction, using the technetium-99m ({sup 99m}Tc) tetrofosmin (SPECT) associated with nitrate administration in the detection of hypoperfused but still viable myocardium. The method allows the detection of this disease. [Italian] Il lavoro analizza i risultati degli esami condotti su 22 pazienti con cardiopatia ischemica cronica e ridotta funzione ventricolare sinistra sottoposti a tomografia computerizzata con emissione di fotone singolo (SPECT) cardiaca con tecnezio-99m ({sup 99m}Tc) tetrofosmina associata alla somministrazione di nitrati nella differenziazione tra tessuto miocardico ipoperfuso ma ancora vitale e tessuto miocardico necrotico. La metodologia usata consente di identificare la presenza di tessuto miocardico vitale in territori vascolari severamente ipoperfusi.

2000-04-01

378

Spatial distribution of disease: three case studies

Effects of swimming exercise training on left ventricular contraction and relaxation, the incidence of spontaneous defibrillation and the ventricular fibrillation threshold were studied in the isolated, perfused rat heart. The heart/body weight ratio was 4.8 +/- 0.4 x 10(-3) in swimmers compared with 3.9 +/- 0.6 x 10(-3) in sedentary controls (p less than 0.0005). The spontaneous heart rate was lower in isolated hearts of trained animals (222 +/- 18 bpm compared with 244 +/- 28, p less than 0.05). Left ventricular systolic pressure was higher in trained hearts and the rate of ventricular relaxation enhanced (p less than 0.05). The ventricular fibrillation threshold was 7.2 +/- 5.2 and 10.8 +/- 6.1 mamp in hearts of swimmers and controls, respectively, the difference not being significant. The incidence of spontaneous defibrillation was not significantly different between the two groups. It is concluded that, while swimming induces cardiac hypertrophy and ...

1990-12-01

379

Simultaneous assessment of left ventricular function from gated myocardial perfusion SPECT. Utility of QGS (Quantitative Gated SPECT) program

Maps transformed so as to have constant density of residential population were used to analyze the spatial distribution of disease in three specific areas. Each area had received recent attention because of suspected environmental pollution. The area adjacent to the Rocky Flats Facility (CO) was examined to identify any association between possible plutonium releases and increases in lung cancer or leukemia incidence. The industrial area of northern Contra Costa County (CA) was studied to explore a relationship between petrochemical industrial emissions and histologic-specific lung cancers. Finally, a suspected increase in the risk of congenital cardiac defects possibly related to pollution of the Santa Clara County (CA) water supply was investigated. No evidence of elevated risk of disease was found to be associated with either the Rocky Flats Facility or the polluted water of Santa Clara County. An increase in lung cancer, found by other investigators in earlier ...

380

Relationships of valve histology and mitochondrial and myofibril volume densities to hypertrophy of copper-deficient rat hearts

Quantitative gated SPECT (QGS) was evaluated in 7 normal volunteers and 31 patients with cardiac diseases. Adequate cut off value of a prefilter was 0.45. In phantom, the left ventricular volume value was 93.9% of determined value by 180-degree projection in L type and 98.8% by 360-degree projection in opposed type. In normal volunteers, LVEF measured by QGS program related to value by first pass method. As for functional map, regional EF and wall motion decreased at the septum side, and wall thickening at base side of heart. Good correlation was recognized (p<0.0001) between blood flow image and functional map (regional EF and wall thickening). In 20 cases of acute myocardial infarction, lesion was detected conspicuously in regional EF and wall motion. The accuracy of coronary arterial stenosis improved in functional map (regional EF 92%, wall motion 92% and wall thickening 88%). In particular, the accuracy of 3 rami lesion was 100% in functional map and higher ...

1998-08-01

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381

Radiant{trademark} Liquid Radioisotope Intravascular Radiation Therapy System

Twenty-four male weanling rats were fed either copper-adequate or -deficient diets until 9 or 11 weeks of age. Deficient rat hearts had increased mitochondria: myofibril compared to adequate rats. Eleven week old deficient rat hearts had decreased mitochondria: myofibril as the hearts increased in weight, but the larger hearts had greater myofibril volume densities. Cardiac mitochondria of deficient rats appeared vacuolated with fragmented cristae and translucent matrix. Valves from copper deficient rats appeared to have less connective tissue and were fragmented in areas. For deficient rats, heart:body weights of 9 wk old rats were negatively correlated with bicuspid valve pathology scores, whereas tricuspid valve scores from 11 wk old rats were negatively correlated with myofibril volume densities. These data suggest that the enlargement of the copper-deficient rat heart is due to: larger (1) mitochondria and (2) myofibril volume densities.

1991-03-15

382

Prevention and Treatment of Functional and Structural Radiation Injury in the Rat Heart by Pentoxifylline and Alpha-Tocopherol

RADIANT{trademark} is manufactured by United States Surgical Corporation, Vascular Therapies Division, (formerly Progressive Angioplasty Systems). The system comprises a liquid {beta}-radiation source, a shielded isolation/transfer device (ISAT), modified over-the-wire or rapid exchange delivery balloons, and accessory kits. The liquid {beta}-source is Rhenium-188 in the form of sodium perrhenate (NaReO{sub 4}), Rhenium-188 is primarily a {beta}-emitter with a physical half-life of 17.0 hours. The maximum energy of the {beta}-particles is 2.1 MeV. The source is produced daily in the nuclear pharmacy hot lab by eluting a Tungsten-188/Rhenium-188 generator manufactured by Oak Ridge National Laboratory (ORNL). Using anion exchange columns and Millipore filters the effluent is concentrated to approximately 100 mCi/ml, calibrated, and loaded into the (ISAT) which is subsequently transported to the cardiac catheterization laboratory. The delivery catheters are modified ...

1998-01-16

383

British Library Electronic Table of Contents (United Kingdom)

Purpose Radiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of pentoxifylline (PTX) and a-tocopherol on cardiac injury in a rat model of RIHD. Methods and Materials Male Sprague-Dawley rats received fractionated local heart irradiation with a daily dose of 9 Gy for 5 days and were observed for 6 months after irradiation. Rats were treated with a combination of PTX, 100 mg/kg/day, and a-tocopherol (20 IU/kg/day) and received these compounds either from 1 week before until 6 months after irradiation or starting 3 months after irradiation, a time point at which histopathologic changes become apparent in our model of RIHD. Results Radiation-induced increases in left ventricular diastolic pressure (in mm Hg: 35 +- 6 after sham...

2008-01-01

384

Platelet thrombosis in cardiac-valve prostheses

Non-white noise in fMRI: does modelling have an impact?

The contribution of platelets and clotting factors in thrombosis on cardiovascular prostheses had been quantified with several tracers. Thrombus formation in vivo could be measured semiquantitatively in animal models and patients with indium-111, Technetium-99m labeled platelets, iodine-123, iodine-131 labeled fibrinogen, and In-111 and Tc-99m labeled antibody to the fibrinogen-receptor on the platelet- membrane, or fibrin. The early studies demonstrated that certain platelet-inhibitors, e.g. sulfinpyrazone, aspirin or aspirin- persantine increased platelet survival time with mechanical valves implanted in the baboon model and patients. Thrombus localization by imaging is possible for large thrombus on thrombogenic surface of prosthesis in the acute phase. The majority of thrombus was found in the sewing ring (Dacron) in the acute phase in both the mechanical and tissue valves. The amount of retained thrombus in both mechanical and tissue valves in our one-day study in the dog model ...

1989-06-08

385

DEFF Research Database (Denmark)

The sources of non-white noise in Blood Oxygenation Level Dependent (BOLD) functional magnetic resonance imaging (fMRI) are many. Familiar sources include low-frequency drift due to hardware imperfections, oscillatory noise due to respiration and cardiac pulsation and residual movement artefacts not accounted for by rigid body registration. These contributions give rise to temporal autocorrelation in the residuals of the fMRI signal and invalidate the statistical analysis as the errors are no longer independent. The low-frequency drift is often removed by high-pass filtering, and other effects are typically modelled as an autoregressive (AR) process. In this paper, we propose an alternative approach: Nuisance Variable Regression (NVR). By inclusion of confounding effects in a general linear model (GLM), we first confirm that the spatial distribution of the various fMRI noise sources is similar to what has already been described in the literature. Subsequently, we ...

2005-01-01

386

Non-white noise in fMRI: Does modelling have an impact?

DEFF Research Database (Denmark)

The sources of non-white noise in Blood Oxygenation Level Dependent (BOLD) functional magnetic resonance imaging (fMRI) are many. Familiar sources include low-frequency drift due to hardware imperfections, oscillatory noise due to respiration and cardiac pulsation and residual movement artefacts not accounted for by rigid body registration. These contributions give rise to temporal autocorrelation in the residuals of the fMRI signal and invalidate the statistical analysis as the errors are no longer independent. The low-frequency drift is often removed by high-pass filtering, and other effects are typically modelled as an autoregressive (AR) process. In this paper, we propose an alternative approach: Nuisance Variable Regression (NVR). By inclusion of confounding effects in a general linear model (GLM), we first confirm that the spatial distribution of the various fMRI noise sources is similar to what has already been described in the literature. Subsequently, we ...

2006-01-01

387

Natriuretic peptides in the pathophysiology of congestive heart failure.

Metallic implants and exposure to radiofrequency radiation

A hallmark of congestive heart failure (CHF) is the activation of the cardiac endocrine system, in particular atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). The natriuretic peptides are a group of structurally similar but genetically distinct peptides that have diverse actions in cardiovascular, renal, and endocrine homeostasis. ANP and BNP are of myocardial cell origin and C-type natriuretic peptide (CNP) is of endothelial origin. ANP and BNP bind to the natriuretic peptide-A receptor (NPR-A), which, via 3',5'-cyclic guanosine monophosphate (cGMP), mediates natriuresis, vasodilatation, renin inhibition, antimitogenesis, and lusitropic properties. CNP lacks natriuretic actions but possesses vasodilating and growth inhibiting actions via the guanylyl cyclase-linked natriuretic peptide-B receptor. All three peptides are cleared by the natriuretic peptide-C receptor and degraded by the ectoenzyme neutral endopeptidase 24.11, both of which are ...

2000-05-01

388

Macroscopic consequences of calcium signaling in microdomains: A first passage time approach

There is increasing use of radiofrequency radiation (RFR) in industry for communications, welding, security, radio, medicine, navigation etc. It has been recognised for some years that RFR may interact with cardiac pacemakers and steps have been taken to prevent this interference. It is less well recognised that other metallic implants may also act as antennas in an RFR field and possibly cause adverse health effects by heating local tissues. There are a large and increasing number of implants having metal components which may be found in RFR workers. These implants include artificial joints, rods and plates used in orthopaedics, rings in heart valves, wires in sutures, bionic ears, subcutaneous infusion systems and (external) transdermal drug delivery patches"1. The physician concerned with job placement of such persons requires information on the likelihood of an implant interacting with RFR so as to impair health. The following outlines the approach developed in ...

389

MRI of congenital heart disease in childhood

Calcium (Ca) plays an important role in regulating various cellular processes. In a variety of cell types, Ca signaling occurs within microdomains where channels deliver localized pulses of Ca which activate a nearby collection of Ca-sensitive receptors. The small number of channels involved ensures that the signaling process is stochastic. The aggregate response of several thousand of these microdomains yields a whole-cell response which dictates the cell behavior. Here, we study analytically the statistical properties of a population of these microdomains in response to a trigger signal. We apply these results to understand the relationship between Ca influx and Ca release in cardiac cells. In this context, we use a first passage time approach to show analytically how Ca release in the whole cell depends on the single channel kinetics of Ca channels and the properties of microdomains. Using these results, we explain the underlying mechanism for the graded ...

2007-01-01

390

Influence of iron deficiency in the radiopharmaceutical behavior of red blood cells labeled with "9"9"mTc("9"9"mTC-RBC)

MRI provides a non-invasive diagnostic tool complementing echocardiography on one hand, and showing advantages over echocardiography, on the other hand, especially after corrective procedures. The multiple different MRI sequences need to be adapted to examinations of children and patients with congenital heart disease (CHD), and can be used to detect morphologic changes, blood-flow in the heart and thoracic vessels and diastolic or systolic function of myocardium. Several factors determine the success of the examination of a complex congenital heart disease or a postoperative situs. Pediatric radiologists and radiologists experienced in congenital heart diseases have to work in close cooperation. Echocardiography should be performed before MRI. The results of prior examinations and the clinical history of the patients, including possible palliative or reconstructive operations, must be available before MRI to guide the planning of the examination. With a systematic segmental approach ...

2004-02-01

391

Immunolocalization of endothelin-B receptor in mouse intestinal tract.

Full text: Red blood cells (RBCs) labeled with "9"9"mTc are commonly used in the evaluation of cardiac function, gastrointestinal tract bleeding, red blood cell volume or splenic sequestration. Generally stannous ion is used as reducing agent. A proposed mechanism is that once the stannous ion (Sn) and the pertechnetate ("9"9"mTc) reach the interior of the RBC, the radionuclide is mainly house in the #beta#-chain of hemoglobin. The aim of this study was to determine if hemoglobin content reduction, an indicator of iron deficiency anemia, could affect the efficiency of RBC labeling and the biological distribution of this radiopharmaceutical. We studied 30 rats fed for 3 weeks after weaning with diets with iron contents of 6.5 ppm (group A), 18 ppm (group B) and 100 ppm (control). For all groups, the labeling yields were always higher than 97%; the percentage of radioactivity was mostly founded in blood with almost negligible radioactivity the rest of the studied ...

2005-11-09

392

The endothelin-B (ETB) receptor is a G-protein-coupled receptor that binds endothelin ligands and is essential for the development of epidermal melanocytes and enteric neurons. Recent reports indicate that ETB is localized to nuclei in cardiac ventricular myocytes, although it has been thought that ETB is localized mainly on the plasma membrane. It remains unknown, however, whether this unique distribution of ETB occurs in other tissues. To elucidate the subcellular distribution of ETB in the intestine, we performed immunofluorescence of ETB in mouse intestine using a specific antibody. ETB-like immunoreactivity was detected in both the mucosal and muscle layers. In the mucosal layer, villous epithelial cells, stromal cells of the lamina propria, and cryptic cells were immunostained. Subcellularly, ETB is localized mainly to the nuclei of villous epithelial cells. In the muscle layer, immunoreactivity of ETB was localized to the myenteric plexus. These findings ...

2004-11-01

393

Effects of carbon monoxide on myocardial ischemia

This study was performed to assess the possibility that patient age may independently affect improvements in health-related quality of life following percutaneous coronary intervention. One hundred five patients undergoing elective percutaneous coronary intervention at a single tertiary referral center between January 10, 2001 and January 6, 2002 were enrolled and prospectively evaluated. Health-related quality of life was assessed before and 1 year following percutaneous coronary intervention using Short Form-12 and the Seattle Angina Questionnaire. For the purpose of analysis, patients were divided according to age (younger than 60, 60-70, and older than 70 years). One hundred patients (95%) completed both questionnaires. Baseline characteristics among the age groups were similar in terms of gender, cardiac risk factors, and procedural details. All health-related quality-of-life indices demonstrated improvements with at least four variables in each group ...

394

Effect of a reminder video using a mobile phone on the retention of CPR and AED skills in lay responders.

The purpose of this study was to determine whether low doses of carbon monoxide (CO) exacerbate myocardial ischemia during a progressive exercise test. The effect of CO exposure was evaluated using the objective measure of time to development of electrocardiographic changes indicative of ischemia and the subjective measure of time to onset of angina. Sixty-three male subjects (41-75 years) with well-documented coronary artery disease, who had exertional angina pectoris and ischemic ST-segment changes in their electrocardiograms, were studied. Results from three randomized, double-blind test visits (room air, low and high CO) were compared. The effect of CO exposure was determined from the percent difference in the end points obtained on exercise tests performed before and after a 1-hr exposure to room air or CO. A significant dose-response relationship was found for the individual differences in the time to ST end point and angina for the pre-versus postexposure exercise test at the ...

1991-02-01

395

Carvedilol targets human K2P3.1 (TASK1) K+ leak channels

BACKGROUND: : Skills related to cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) use by lay responders decay rapidly after training, and efforts are required to maintain competence among trainees. We examined whether repeated viewing of a reminder video on a mobile phone would be an effective means of maintaining CPR and AED skills in lay responders. METHODS: : In a single-blind case-control study, 75 male students received training in CPR and AED use. They were allocated either to the control or to the video-reminded group, who received a memory card containing a video clip about CPR and AED use for their mobile phone, which they were repeatedly encouraged to watch by SMS text message. CPR and AED skills were assessed in scenario format by examiners immediately and 3 months after initial training. RESULTS: : Three months after initial training, the video-reminded group showed more accurate airway opening (PCPR after defibrillation (PCPR confidence scores ...

2011-09-26

396

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND AND PURPOSE Human K2P3.1 (TASK1) channels represent potential targets for pharmacological management of atrial fibrillation. K2P channels control excitability by stabilizing membrane potential and by expediting repolarization. In the heart, inhibition of K2P currents by class III antiarrhythmic drugs results in action potential prolongation and suppression of electrical automaticity. Carvedilol exerts antiarrhythmic activity and suppresses atrial fibrillation following cardiac surgery or cardioversion. The objective of this study was to investigate acute effects of carvedilol on human K2P3.1 (hK2P3.1) channels. EXPERIMENTAL APPROACH Two-electrode voltage clamp and whole-cell patch clamp electrophysiology was used to record hK2P3.1 currents from Xenopus oocytes, Chinese hamster o...

2011-01-01

397

Assessment of PET and MRI Polar Map using Gaussian Mixture Model

Ambient air pollution and congenital heart disease: a register-based study.

Cardiac disease research relies increasingly on small animal models and non-invasive imaging methods such as positron emission tomography (PET) and magnetic resonance imaging (MRI). Delayed enhancement magnetic resonance imaging (DE-MRI) using gadolinium-based contrast agents appear to be a visualizing infracted myocardium with high spatial resolution. Polar map (or bull's-eye image) was used to determination of the myocardial infarction area. Polar map is a comprehensive interpretation of the left ventricle. The infarct size was computed as the fraction of the total polar map areas. The threshold was computed as the percentage of mean intensity of the normal region. In other study, 50% predefined threshold value in varying range (30?70%) was most commonly use. However, predefined threshold value isn't acceptance in all case. The purpose of this study was to investigate methodological approach for automatic measurement of rat myocardial infarct size using PET and ...

2010-10-01

398

Clinically silent heterotaxy with polysplenia syndrome and IVC azygous continuation draining to SVC: CT findings. Case report

Maternal exposure to ambient air pollution has increasingly been linked to adverse pregnancy outcomes. The evidence linking this exposure to congenital anomalies is still limited and controversial. This case-control study investigated the association between maternal exposure to ambient particulate matter with aerodynamic diameter less than 10 ?m (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxide, nitric oxide (NO), ozone (O(3)), and carbon monoxide (CO) and the occurrence of congenital heart disease in the population of Northeast England (1993-2003). Each case and control was assigned weekly average (weeks 3-8 of pregnancy) of pollutant levels measured by the closest monitor to the mother's residential postcode. Using exposure as both continuous and categorical variables, logistic regression models were constructed to quantify the adjusted odds ratios of exposure to air pollutants and the occurrence of each outcome group. We found exposure to CO and NO to be associated with ...

2011-02-17

399

Triple ion-beam studies of radiation damage effects in a 316LN austenitic alloy for a high power spallation neutron source

Patients with heterotaxy syndrome often have complex cardiac and extracardiac anomalies requiring further detailed diagnostic evaluation. They often present severe cardiac failure early in life. Newer radiological modalities in the form of spiral computed tomography (CT) and three-dimensional reconstruction of spiral CT allow clear definition of the anatomy of these anomalies. A 59-year-old woman was diagnosed with polysplenia and multiple anomalies in an abdominal ultrasonography (US) during a control medical examination due to a trivial dietary mistake. She was then referred to our institution for further examination of these anomalies and an additional thoraco-abdominal computed tomography (CT) examination. The patient was totally asymptomatic at the time of admission. There was no significant past history and no abnormal laboratory data. We performed abdominal, pelvic and thoracic CT examinations using Somatom Siemens Emotion scanner. ...

2007-01-01

400

Radiation-induced damage to DNA; Les lesions radio-induites de l'ADN

Austenitic 316LN alloy was ion-irradiated using the unique Triple Ion Beam Facility (TIF) at ORNL to investigate radiation damage effects relevant to spallation neutron sources. The TIF was used to simulate significant features of GeV proton irradiation effects in spallation neutron source target materials by producing displacement damage while simultaneously injecting helium and hydrogen at appropriately high gas/dpa ratios. Irradiations were carried out at 80, 200, and 350 C using 3.5 MeV Fe{sup ++}, 360 keV He{sup +}, and 180 keV H{sup +} to accumulate 50 dpa by Fe, 10,000 appm of He, and 50,000 appm of H. Irradiations were also carried out at 200 C in single and dual ion beam modes. The specific ion energies were chosen to maximize the damage and the gas accumulation at a depth of {approximately} 1 {micro}m. Variations in microstructure and hardness of irradiated specimens were studied using transmission electron ...

1997-09-01

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401

Preliminary studies of tunnel interface response modeling using test data from underground storage facilities.

This short survey focuses on the main radiation-induced base lesions that have been identified within cellular DNA. For this purpose, sensitive assays that are aimed at measuring a few modifications per 10{sup 7} normal bases were set-up. In that respect high performance liquid chromatography - tandem mass spectrometry (CLHP-MS/MS) was found to be able to single out the formation of 9 oxidized nucleosides and two modified nucleo-bases out of the 70 oxidative base lesions that have been identified in model systems. As a striking result, it was found that in the DNA of {gamma}-irradiated human monocytes, the formamide-pyrimidine derivative of guanine is produced in a higher yield than the ubiquitous 8-oxo-7,8-dihydro-guanine damage, both arising from the same radical precursor. However, relatively high doses of ionizing radiation (> 20 Gy) have to be applied in order to detect an increase in the level of the damage. This is due to the low ...

2002-03-01

402

NO_x emissions from large point sources: variability in ozone production, resulting health damages and economic costs

In attempting to detect and map out underground facilities, whether they be large-scale hardened deeply-buried targets (HDBT's) or small-scale tunnels for clandestine border or perimeter crossing, seismic imaging using reflections from the tunnel interface has been seen as one of the better ways to both detect and delineate tunnels from the surface. The large seismic impedance contrast at the tunnel/rock boundary should provide a strong, distinguishable seismic response, but in practice, such strong indicators are often lacking. One explanation for the lack of a good seismic reflection at such a strong contrast boundary is that the damage caused by the tunneling itself creates a zone of altered seismic properties that significantly changes the nature of this boundary. This report examines existing geomechanical data that define the extent of an excavation damage zone around underground tunnels, and the potential impact on rock ...

2010-11-01

403

Irradiation damage in spinel ceramics MgAl_2O_4 and ZnAl_2O_4: application to the transmutation of the nuclear waste

We present a proof-of-concept analysis of the measurement of the health damage of ozone (O_3) produced from nitrogen oxides (NO_x=NO+NO_2) emitted by individual large point sources in the eastern United States. We use a regional atmospheric model of the eastern United States, the Comprehensive Air quality Model with Extensions (CAMx), to quantify the variable impact that a fixed quantity of NO_x emitted from individual sources can have on the downwind concentration of surface O_3, depending on temperature and local biogenic hydrocarbon emissions. We also examine the dependence of resulting O_3-related health damages on the size of the exposed population. The investigation is relevant to the increasingly widely used 'cap and trade' approach to NO_x regulation, which presumes that shifts of emission over time and space, holding the total fixed over the course of the summer O_3 season, will have minimal effect on the environmental outcome. By ...

2005-05-01

404

Involvement of a glutamergic mechanism in gamma-dendrotoxin-induced hippocampal neuronal cell loss in the rat.

The transmutation of minor actinides in-reactor is one solution currently being studied for the long time management of nuclear waste. In the heterogeneous concept the radionuclides are incorporating in an inert ceramic matrix. The support material must be insensitive to radiation damage. Fission product damage is the main radiation damage source during the transmutation process and therefore it is of the utmost importance to study their effects. We irradiated spinels MgAl_2O_4 (matrix of reference) and ZnAl_2O_4 by fast ions (by example: (86)Kr of approximately 400 MeV) simulating the fission products. Under these conditions, the damage is primarily due to the electronic energy losses (Se). One of the structural features of spinel AB_2O_4 is that the two cations (A(2+) and B(3+)) can exchange their site. This phenomenon is quantified by the inversion parameter. We highlight by XRD in grazing incidence ...

405

Comparison of Ceramic, Metal and Polymer Crevice Formers on the Crevice Corrosopn Behavior of Ni-CR-Mo Alloy C22

The epileptogenic and neurodegenerative effects of gamma-dendrotoxin, from Dendroaspis angusticeps, a specific blocker of a non-inactivating, voltage-sensitive K+ channel, were studied after focal injection into one dorsal hippocampus in rats pretreated with CGP040116, a N-methyl-D-aspartate (NMDA) receptor antagonist, and in rats bearing a monolateral surgical lesion of the Schaffer collaterals whose terminals originate from CA3 pyramids and release glutamate in the CA1 hippocampal area. Administration of 35 pmol gamma-dendrotoxin elicited in all of the treated animals (n=8) bilateral EEG discharges and damage to the hippocampal formation. Quantitation of the damage revealed significant bilateral neuronal cell loss in the CA1, CA3 and CA4 pyramidal cell layers. The lowest dose (0.35 pmol; n=4) of the toxin used did not affect EEG activity and failed to cause significant hippocampal cell loss whereas the 3.5 pmol (n=6) dose caused EEG seizures ...

2004-03-01

406

Atmospheric and geological CO{sub 2} damage costs in energy scenarios

A necessary condition for crevice corrosion is that a crevice former create a sufficiently tight, restricted geometry on the metal surface to support the development of critical crevice chemistry. Crevice corrosion is affected by the crevice geometry (tightness) and the properties of the crevice former. The objective of this study is to determine the effect of the crevice former material on the evolution of localized corrosion-damage. A standard crevice corrosion test method is modified by (a) the use of ceramic, metal or polymer materials as the crevice former and (b) the variation of size and shape of the crevice. This study focuses on the post initiation stage of crevice corrosion and addresses factors that may limit the initiation of localized corrosion and also slow or stop the continued propagation of corrosion. Controlled crevice corrosion tests are performed under aggressive, accelerated conditions on Ni-Cr-Mo alloy C-22 and other alloys for comparison. ...

2006-05-08

407

Atmospheric and geological CO2 damage costs in energy scenarios

This paper assesses the effects of including carbon dioxide capture and storage (CCS) damage costs in a long-term energy scenario analysis for Europe. An external cost sensitivity analysis is performed with a bottom-up energy technology model that accounts not only for CCS technologies but also for their external costs. Our main conclusion is that in a business-as-usual scenario (i.e. without climate change intervention or externality internalisation), CCS technologies are likely to be deployed at least to some extent, mainly in the power generation sector, given the economic benefits of opportunities such as enhanced coal bed methane, oil and gas recovery. Under a strict climate (CO{sub 2} emissions) constraint, CCS technologies are deployed massively. With the simultaneous introduction of both CO{sub 2} and CCS taxation in the power sector, designed to internalise the external atmospheric and geological effects of CO{sub 2} emissions and storage, respectively, we ...

2006-05-15

408

Ultrastructural effect of gamma radiation on grass shrimps (Penaeus monodon Fabricius)

Geological carbon dioxide capture and storage (CCS) is currently seriously considered for addressing, in the near term, the problem of climate change. CCS technology is available today and is expected to become an increasingly affordable CO2 abatement alternative. Whereas the rapidly growing scientific literature on CCS as well as experimental and commercial practice demonstrate the technological and economic feasibility of implementing this clean fossil fuel option on a large scale, relatively little attention has been paid so far to the risks and environmental externalities of geological storage of CO2. This paper assesses the effects of including CCS damage costs in a long-term energy scenario analysis for Europe. An external cost sensitivity analysis is performed with a bottom-up energy technology model that accounts not only for CCS technologies but also for their external costs. Our main conclusion is that in a business-as-usual scenario (i.e. without climate ...

409

Ultrastructural effect of gamma radiation on grass shrimps (Penaeus monodon Fabricius)

The effect of ionizing radiation (2, 5, and 10 KGy of gamma rays) on muscle ultrastructure of grass shrimps (Penaeus monodon Fabricius) tails at ambient or frozen (-18{sup 0}C) temperature was investigated by transmission electron microscopy (TEM). No significant change was found in muscle ultrastructure of shrimp meat irradiated at doses of 2 or 5 KGy and then stored at 4{sup 0}C for 0 and 8 days. However, in shrimps which were irradiated at ambient temperature at a dose of 10 KGy, the margin of A-band of the myofibrils in longitudinal sections exhibited an irregular zig-zag pattern. In cross section some myosin filaments in the A-band regions were missing. A possible interpretation of these results would be that 10 KGy gamma irradiation dose at ambient temperature depolymerized myosin in the A-band from the tail of thick filament. Actin damage was also observed in some cross sections. Irradiation damage of sarcoplasmic membranes appeared in ...

1990-01-01

410

Standardizing regulations on production of mining electrical equipment

The effect of ionizing radiation (2, 5, and 10 KGy of gamma rays) on muscle ultrastructure of grass shrimps (Penaeus monodon Fabricius) tails at ambient or frozen (-18"0C) temperature was investigated by transmission electron microscopy (TEM). No significant change was found in muscle ultrastructure of shrimp meat irradiated at doses of 2 or 5 KGy and then stored at 4"0C for 0 and 8 days. However, in shrimps which were irradiated at ambient temperature at a dose of 10 KGy, the margin of A-band of the myofibrils in longitudinal sections exhibited an irregular zig-zag pattern. In cross section some myosin filaments in the A-band regions were missing. A possible interpretation of these results would be that 10 KGy gamma irradiation dose at ambient temperature depolymerized myosin in the A-band from the tail of thick filament. Actin damage was also observed in some cross sections. Irradiation damage of sarcoplasmic membranes appeared in the ...

411

Serviceability of steam generators at NPPs with reactors of the WWER-440 and WWER-1000 types

The paper evaluates standardization of regulations on safety of electrical equipment for underground coal mines in the USSR. Factors increasing hazards of electrical failures of equipment in underground coal mines are analyzed: reduced lighting, increased humidity and dusts, damage caused by falling rocks or damage during haulage in underground workings, installation of electrical equipment in places easily accessible to untrained personnel. Standards on safety of electrical equipment for underground coal mining valid in the USSR are reviewed: the PIRNEh regulations on production of electrical equipment for coal mines developed by the VNIIVEh Institute, and the GOST national standards. International cooperation within the COMECON on safety of mining electrical equipment (the Interelectro Committee of the COMECON) is described. Certification of electrical equipment for coal mines is discussed on the example of electrical insulation types used in ...

1983-02-01

412

Progress in optical coatings for the mid-infrared

Steam generators (SG) are the weak link of nuclear power plants, their service life is shorter than the service life of other NPP components. This paper is dedicated to a statistical analysis of SG damages and failures. Heat exchanging tubes (HET) are the most damaged elements in SG, there are on average 286 plugged or repaired tubes in each operating SG. The usually mechanisms of tube failure are the following: denting, corrosion at tube outside, pitting, fretting, and circular crack propagation. Most of damages are located in the transition zone above a tube plate. This study shows that the factors that are involved in the SG HET fault probability are: - design features of SG and secondary equipment elements (high pressure feed heaters (HPFH), low pressure feed heater (LPFH)), - water chemistry at different points of condensate feed pipe, composition and density of deposits on HET surface, efficiency of mechanical and ...

2002-07-01

413

Pipe-to-pipe impact program

There has been a growing interest in new laser systems for use at mid-infra-red wavelengths, driven by requirements for a number of diverse applications. Developments in mid-IR coating technology are following three major thrusts. In the first, the potential of ion-assisted process is being exploited and the technology is already becoming well established in the optical coating industry. In the second, the benefits of using gas-phase precursors are being explored, driven by the potential of avoiding the generation of second phase inclusion in the coatings with associated reduction in laser damage threshold. Research is also addressing the use of nanocomposite materials with an engineered microstructure to produce coatings with dielectric properties of choice. This paper presents a review of progress in some of these areas with special emphasis on the comparison of the properties of materials at DF laser wavelengths. Evidence is presented which suggests that laser ...

1996-10-07

414

Physically based modelling of damage, amorphization, and recrystallization for predictive device-size process simulation

The objective of this research was to determine the extent of damage that occurs when two pipes experience an impact event due to one whipping against the other. The research was conducted through experimental and analytical approaches. The former required the development of a specialized impact machine that could accelerate a whipping pipe with sufficient energy to cause failure of a target pipe that was heated and pressurized to Pressurized Water Reactor (PWR) conditions. Damage was measured in terms of crushing, bending, and failure. The results of the tests permitted the correlation between pipes of a certain size and the damage they could cause when impacting with a certain amount of known energy. These results were used to evaluate the pipe whip criteria in the Standard Review Plan 3.6.2-4. It was established that the criteria conditions did not fully represent the results obtained experimentally. An analysis ...

1987-05-01

415

Physically based modelling of damage, amorphization, and recrystallization for predictive device-size process simulation

Current advanced CMOS source/drain engineering involves the use of amorphizing implants with 3D geometry. Upon annealing, the induced transient enhanced diffusion (TED) can only be accurately predicted if the amorphized region is correctly modeled, as well as the formation and evolution of extended defects, particularly 3 1 1's and dislocation loops. In addition to the extended defects, already modeled in the atomistic kinetic Monte-Carlo simulator DADOS, we have developed a physically based modeling approach for the implant-induced damage build-up, amorphization and recrystallization, suitable to handle device-size process simulation. It is based on amorphous pockets (3D, irregular shape agglomerates of an arbitrary number of interstitials and vacancies, plus trapped impurities) with a size-dependent activation energy for recombination. The model is able to reproduce experimental aspects like the crystal-amorphous transition temperature and the super ...

2004-12-15

416

Minority-carrier lifetime damage coefficient of irradiated InP

Current advanced CMOS source/drain engineering involves the use of amorphizing implants with 3D geometry. Upon annealing, the induced transient enhanced diffusion (TED) can only be accurately predicted if the amorphized region is correctly modeled, as well as the formation and evolution of extended defects, particularly 3 1 1's and dislocation loops. In addition to the extended defects, already modeled in the atomistic kinetic Monte-Carlo simulator DADOS, we have developed a physically based modeling approach for the implant-induced damage build-up, amorphization and recrystallization, suitable to handle device-size process simulation. It is based on amorphous pockets (3D, irregular shape agglomerates of an arbitrary number of interstitials and vacancies, plus trapped impurities) with a size-dependent activation energy for recombination. The model is able to reproduce experimental aspects like the crystal-amorphous transition temperature and the super linear ...

2004-12-15

417

Materials choices for the advanced LWR steam generators

Minority-carrier lifetime damage coefficients for 1 MeV electron, 3 MeV proton, and 6 MeV alpha particle irradiation of n-type (4.5{times}10{sup 15} and 1.3{times}10{sup 17}cm{sup {minus}3}) and p-type (2.5{times}10{sup 17}cm{sup {minus}3}) InP have been measured using time-resolved photoluminescence. These values are relatively insensitive to carrier type and show a slight increase with increasing carrier concentration. Evidence of comparable electron and hole capture lifetimes is found for the dominant recombination defect. The effect of 3 MeV proton and 6 MeV alpha particles relative to 1 MeV electrons is an increase in the lifetime damage coefficient by factors of about 10{sup 4} and 10{sup 5}, respectively. {copyright} {ital 1997 American Institute of Physics.}

1997-09-01

418

Examples of damaged aircraft engines; Beispiele fuer Schaeden an Flugtriebwerken

Current light water reactor (LWR) steam generators have been affected by a variety of corrosion and mechanical damage degradation mechanisms. Included are wear caused by tube vibration, intergranular corrosion, pitting, and thinning or wastage of the steam generator tubing and accelerated corrosion of carbon steel supports (denting). The Electric Power Research Institute (EPRI) and the Steam Generator Owners Groups (I, II) have sponsored laboratory and field studies to provide ameliorative actions for the majority of the damage forms experienced to date. Some of the current corrosion mechanisms are aggravated or caused by unique materials choices or materials interactions. New materials have been proposed and at least partially qualified for use in replacement model steam generators, including an advanced LWR design. In so far as possible, the materials choices for the advanced LWR steam generator avoid the corrosion pitfalls seemingly inherent ...

1987-11-15

419

Enhanced defect detection and sizing accuracy using matrix phased array ultrasonic tools

Some of the smaller sports- und travel aircrafts are still propelled by piston engines. The first part of the article looks into some characteristic damage incidents that occur in aircraft engines. Not surprisingly, vibration fatigue failure happens most frequently. Apart from technical faults it is surprisingly lack of fuel that accounts for the high incidence of engine failure (one third). Flight turbines occasionally fail due to vibration fatigue of component parts. Added to this thermal fatigue cracks and damage due to overheating may occur in a gas turbine while the compressor parts may be affected by corrosion. (orig.) [German] Ein erheblicher Teil der kleineren Sport- und Reiseflugzeuge ist auch heute noch mit Kolbentriebwerken ausgestattet. Im ersten Teil des Aufsatzes werden daher einige charakteristische Schaeden an Flugmotoren vorgestellt. Als Versagensart dominiert erwartungsgemaess der Schwingbruch (Dauerbruch). Neben den technisch ...

1998-07-01

420

Effective removal of Ga residue from focused ion beam using a plasma cleaner

Although ultrasonic testing inspection technology and tools have improved significantly, there is still a need for more reliable detection, monitoring, and accurate sizing of crack-like and planar defects, complex corrosion damage, and detection of secondary features within deformed pipe. Ultrasonic two dimensional (2D) matrix phased array technology offers some unique advantages that make the technology promising for improving detection and sizing of pipeline flaws resulting from welding or from in-service damage. Ultrasonic modeling and simulation has been conducted to evaluate the detection and sizing capabilities of 2D matrix arrays for various pipeline inspection concepts. Simulations have been performed using both flexible and rigid array probes. Inspection concepts using rigid probes were evaluated for inspections from both the outside and inside pipe surfaces, while flexible probes were evaluated primarily for inspection from the ...

2009-07-01

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421

Dependence of anomalous phosphorus diffusion in silicon on depth position of defects created by ion implantation

Samples prepared using the focused ion beam (FIB) inevitably contain the surface damage induced by energetic Ga"+ ions. An effective method of removing the surface damage is demonstrated using a plasma cleaner, a device which is widely used to minimize the surface contamination in scanning transmission electron microscopy (STEM). Surface bombardment with low-energy Ar"+ ions was induced by biasing the sample immersed in the plasma source, so as to etch off the surface materials. The etch rates of SiO_2, measured with a bias voltage of 100-300 V, were found to vary linearly with both the time and bias and were able to be controlled from 1.4 to 9 nm/min. The removal of the Ga residue was confirmed using energy dispersive spectroscopy (EDS) after the plasma processing of the FIB-prepared sample. When the FIB-prepared sample was processed via plasma etching for 10 min with a bias of 150 V, the surface Ga damage was completely ...

422

Chemical source identifications for natural resource injury/damage assessments and site assessments

Transient enhanced diffusion of phosphorus in silicon has been investigated for implants below and above the threshold for a complete amorphization. Rapid thermal processes (electron beam) and conventional furnaces have been used for the annealing. In the case of implants below amorphization, a strong enhanced diffusion, proportional to the amount of damage produced, has been observed. The extent of the phenomenon is practically independent of the damage depth position. In contrast to this, the formation of extended defects at the original amorphous-crystalline interface makes the diffusivity strongly dependent on depth in the case of post-amorphized samples. No enhanced diffusion effect is observed if the dopant is confined in the amorphous layer, while a remarkable increase in the diffusivity is detected for the dopant located in the crystalline region beyond the amorphous-crystalline interface. Damage distribution after ...

1989-03-01

423

A Cloud Computing Approach to Personal Risk Management: The Open Hazards Group

Current regulations guiding technical aspects of natural resource damage assessments combine source, exposure pathway, resource injury, and monetary damage components. In order to associate any observed injury to the uncontrolled release of chemicals (e.g. oil spills, contaminated sediments, in-place toxics, etc.), it is important to link the chemical ''release'' to the injured resource. In complex environmental settings where multiple sources of similar chemicals are combined, multicomponent chemical methods must be used to link the release to the environmental distribution of chemicals. Three examples of the utility of multicomponent organic chemical analyses linked to comprehensive and representative sampling strategies will be discussed--the Shell Martinez Refinery oil spill, the Exxon Valdez oil spill, and a contaminated sediment assessment. These NRDA-based source identifications are based on use of polycyclic aromatic hydrocarbons, ...

1993-11-14

424

Vegetation Growth Monitoring Under Coal Exploitation Stress by Remote Sensing in the Bulianta Coal Mining Area

According to the California Earthquake Authority, only about 12% of current California residences are covered by any form of earthquake insurance, down from about 30% in 1996 following the 1994, M6.7 Northridge earthquake. Part of the reason for this decreasing rate of insurance uptake is the high deductible, either 10% or 15% of the value of the structure, and the relatively high cost of the premiums, as much as thousands of dollars per year. The earthquake insurance industry is composed of the CEA, a public-private partnership; modeling companies that produce damage and loss models similar to the FEMA HAZUS model; and financial companies such as the insurance, reinsurance, and investment banking companies in New York, London, the Cayman Islands, Zurich, Dubai, Singapore, and elsewhere. In setting earthquake insurance rates, financial companies rely on models like HAZUS, that calculate on risk and exposure. In California, the process begins with an official ...

2010-12-01

425

British Library Electronic Table of Contents (United Kingdom)

Coal exploitation inevitably damages the natural ecological environment through large scale underground exploitation which exhausts the surrounding areas and is the cause of surface subsidence and cracks. These types of damage seriously lower the underground water table. Deterioration of the environment has certainly an impact on and limits growth of vegetation, which is a very important indicator of a healthy ecological system. Dynamically monitoring vegetation growth under coal exploitation stress by remote sensing technology provides advantages such as large scale coverage, high accuracy and abundant information. A scatter plot was built by a TM (Thematic Mapper) infrared and red bands. A detailed analysis of the distributional characteristics of vegetation pixels has been carried out. ...

2007-01-01

426

The basic experiment on the high-temperature chemical reaction between sodium compound and iron-base material. Pt. 2. Structure observations

The Seismic Risk Explorer - A Scenario Tool for Assessing Seismic Risk

This experiment is carried out in the series of the investigation on the damage mechanism of carbon steel. In this paper, the damage situation is considered by structure observations. The test were carried out in 600degC-1200degC temperature range, in blowing an argon gas. The reagents are Na{sub 2}O, Na{sub 2}O{sub 2} and NaOH. From structure observations, the holes are observed on the surface of iron-base material in some test conditions. This result is indicated that the selective reaction occurs. The selective reaction is more obvious as the time exposed to the high temperature is longer. It is considered that the selective reaction occurs after the chemical reaction between iron-base material and sodium compound. The areas, in which Mn-concentration is higher, are observed in products on the surface of specimen. (author)

1997-07-01

427

The EKC for SO2: Does firm size matter?

The Seismic Risk Explorer, an extension for ArcGIS Desktop developed by cedim AG, is a tool for computing the seismic risk, i.e. damage on residential buildings and thereby caused monetary losses for earthquake scenarios. It is based on the research results of the CEDIM (Center for Disaster Management and Risk Reduction Technology) research center, located at the Karlsruhe Institute of Technology (KIT) and the GeoForschungsZentrum (GFZ) in Potsdam. With this software tool seismic scenarios can be simulated for a given magnitude, depths and location. The seismic intensity, the resulting mean damage ratio for residential buildings and the seismic risk, expressed as the monetary loss caused by an earthquake can be computed downscaled to communities, postcode areas or even single buildings. Interested end-users are especially insurance companies, but also public authorities which may use the tool for risk management issues.

2009-04-01

428

British Library Electronic Table of Contents (United Kingdom)

The environmental Kuznets curve hypothesis (EKC) predicts an inverse U-shaped relationship between environmental pollution and per capita income. The literature with respect to the EKC is vast but far from conclusive. This paper adds firm size to the standard EKC reduced form regression and analyses whether firm size matters once income and composition are controlled for. Results suggest that large firm countries are initially associated with higher levels of environmental damage. However, as economies develop, large firm countries find it easier to adopt more stringent environmental legislation. Once environmental damage starts to decrease, the decrease is much larger in large firm countries.

2006-01-01

429

Tetracycline ulcers of the oesophagus

Surge-line thermal stratification: Displacements and fatigue damage computations

Two cases of tetracycline ulcers of the oesophagus are reported and compared with thirteen other cases from the literature. In most cases, the patients had taken their capsules with little or no fluid just before going to bed. Some hours later they developed retrosternal pain that was intensified by swallowing. Endoscopy showed sharply demarcated greyish-white areas of mucosal damage which represented layers of stratified squamous cells, separated by oedema, and a dense neutrophilic infiltration of the lamina propria and the muscularis mucosa. Roentgenology was unsuitable to detect the lesions. They healed without complications within one to six weeks. Prolonged retention of the capsules in the oesophagus is thought to cause the mucosal damage. Patients on oral tetracycline or doxycycline treatment should therefore be instructed to take their capsules with a meal or with copious water and not just before going to bed.

1981-11-01

430

Surface effects of total coal-seam extraction by underground mining methods

Slow, unexpected displacements have been experienced in most pressurized water reactor (PWR) surge lines. Sometimes, these displacement lead to gap closure at the pipe whip restraints. These movements occur because of thermal stratification. This movement has the potential to increase stresses to valves, which may exceed the material yield stress. To understand this phenomenon, Framatome, Commissariat a l'Energie Atomique, and Electricite de France have undertaken large programs for the study of (1) thermal-hydraulic tests with a half-scale Plexiglas surge line, (2) thermal-hydraulic computations of permanent states and transients with a two-dimensional model, and (3) mechanical analysis of displacements and computation of fatigue damage due to stratification. This paper deals with the last subject. Avoiding stratification in piping by process modifications is difficult because of the high flow rate needed. Alternative solutions for coping with ...

1989-01-01

431

Structural health monitoring of constrained tapered beamlike structures using natural frequencies and nodal points

The paper gives a detailed overview of the history of subsidence engineering in South African collieries. Surface displacements resulting from total-seam extraction are discussed, and the important role of local geology is highlighted. It is shown that the differences in subsidence behaviour between South African and European collieries can be attributed to the presence of competent strata in the overburden of South African coal seams. Criteria are given for the prediction of the most important subsidence parameters, and a new model for the simulation of surface subsidence above total-extraction panels is introduced. The final section of the paper deals with the damage to surface structures caused by total-seam extraction. A brief summary of the most important undermining experiments in South African collieries is given, and it is concluded that local experiences of damage compare with those in Europe. 32 refs., 9 figs., 3 tabs.

1991-07-01

432

Seismic retrofitting of nonductile beam-column sub-assemblage using FRP wrapping and steel plate jacketing

The integrity and safety of beam-like structures are dependent in part on their boundary conditions which can vary with time due to damage or aging. Structural health monitoring of such structures should therefore include attention to boundary conditions. Where the boundary conditions can be represented by a lumped spring then the identification of associated stiffness parameter values may be a means to quantifying the integrity of the support. This paper investigates such a method for identifying the equivalent translational and rotational stiffness of a constrained tapered beam-like structure. An analytical model of a beam of tapered width and thickness is adopted as a simplified representation of a tower-like structure. The model is used to explore in what scenarios natural frequencies and/or nodal points might be sufficiently sensitive to changes in support conditions to be measurable indicators of damage. The method is evaluated by Monte ...

2011-07-01

433

British Library Electronic Table of Contents (United Kingdom)

The paper discusses the aspects of repair and retrofitting technique adopted for a damaged reinforced concrete beam-column joint specimen under cyclic loading. A specimen designed based on Indian Standard specifications with consideration of seismic load but without adopting ductile detailing (NonDuctile) was investigated under reverse cyclic loading. Then, the damaged nonductile specimen was repaired with epoxy mortar and grouted using low viscous polymer, and retrofitted using fiber reinforced plastic (FRP) wrapping in beam and column components and steel plate jacketing in joint region. The experimental results showed that the retrofitted specimen not only regained its original strength and stiffness but also has overcome the deficiencies of nonductile detailing. The present study shows...

2011-01-01

434

Recent advance of focused ion beam technology in maskless deposition and patterning

Preliminary Calculations of the Radiation Damage of the Permanent Magnets for TRADE (TRiga Accelerator Driven Experiment)

The present article will review recent advances in focused ion beam (FIB) technology. With increasing demands for scale of integration, microfabrication technology is becoming more important and various new microfabrication tools and processing techniques are desired. FIB is one of the promising tools for future microfabrication technology. This provides maskless patterning capability, which is of importance for process simplification, nanofabrication and in the development of in situ vacuum processing. In situ vacuum processing systems are being developed by combining FIB and a molecular beam epitaxy system. Radiation damage may limit applications of FIB. However, it was demonstrated that low energy FIB (<1 keV) with very high brightness was reached and promising results for low damage processing have been obtained. (orig.).

435

Particle and X-ray damage in pn-CCDs

Monte Carlo calculations of proton irradiation of permanent magnets for the TRADE experiment have been performed. An irradiation dose of about 4´106 Gy/yr/mA has been estimated due to beam losses in normal operating conditions. Existing experimental results indicate that this irradiation level may induce a considerable demagnetization: in fact, a dose of 6´107 Gy induces a remanence loss of 0.3 % on samples of Sm2Co17 magnets, which are the most resistant type. More detailed calculations with the final design of the magnets and of the beam line are suggested, to determine if the irradiation levels allowed a reliable operation of the permanent magnets for the entire duration of the TRADE experiment. Damage and gas production rates have also been calculated; the values obtained are very low, thus confirming that the demagnetization process is in great part reversible.

2002-01-01

436

Observation of 77 K staircase I-V characteristics in 2DEG's irradiated by a focused ion beam

The fully depleted pn-junction charge coupled device (pn-CCD) has been developed as a detector for X-ray imaging and high-resolution spectroscopy for the X-ray satellite missions XMM and ABRIXAS. If the detector is exposed to a particle radiation environment, the energy resolution is degraded due to charge transfer losses and a dark current increase. In a first experiment, prototype devices were irradiated with 10 MeV protons. After completion of the detector development, the proton irradiation was repeated for a quantitative study of the radiation damage, relevant for the satellite missions. The irradiation test was extended by a 5.5 MeV {alpha}-particle and a 6 keV X-ray exposure of the pn-CCD, including the CAMEX preamplifier chip.

2000-01-11

437

Nonverbal Learning Disability explained: the link to shunted hydrocephalus

Staircase current-voltage (I-V) characteristics, observed at 77 K in narrow 2DEG channels irradiated by a single line scan of a focused ion beam (FIB), is reported in detail. These staircases are interpreted as evidence of single electron tunneling through a naturally occurring specific Coulomb island in the random potential fluctuations created by FIB damage. Clear comparison is made between the I-V's taken from wide channels and those from narrow channels. Based on orthodox calculations of the I-V characteristics, it is shown that highly asymmetric tunnel junctions are needed to explain our data. This is consistent with the random nature of the potential landscape in the FIB damaged region. (author).

438

British Library Electronic Table of Contents (United Kingdom)

Accessible summary - -Children with a Nonverbal Learning Disability (NLD) resulting from shunted hydrocephalus and spina bifida face many difficulties not experienced by those with a language learning disability. - -As they grow older and more autonomy is expected, friendships became harder to sustain and daily life can be full of fear if the nonverbal learning disability is not identified and managed. - -This paper explains the theorised cause of nonverbal learning disability - damage to right hemisphere white matter or myelin. - -Damage is believed to cause problems with planning, organisation, time management, problem-solving, decision-making and friendships, and the mismatch with articulate speech and a good vocabulary causes a functional profile that is difficult for educationists or ...

2011-01-01

439

Microstructural characteristics and creep rupture behavior of electron beam and laser welded AISI 316L stainless steel

Microstructural characteristics and creep rupture behavior of electron beam and laser welded AISI 316L stainless steel

AISI 316L stainless steel was welded by the electron beam (EB) and laser techniques. Microstructural characteristics, hardness profile, creep rupture properties and creep damage of the welds were investigated. Fully austenitic microstructure was obtained in the two welds. The solidification structure of the welds consisted of the cellular and equiaxed dendrites. The creep rupture lives of the two welds were almost the same, and they were reduced by a factor of about two compared to the base metal. Moreover, the rupture elongation of the welds was lower than that of the base metal. Creep damage was observed in the ``parting`` region of the welds and in the heat-affected zone (HAZ), respectively. Final creep fracture occurred in the ``parting`` region of the welds. (orig.).

1995-12-01

440

Investigation of changes in hyperfine interaction and Debye-Waller-factor by #alpha#-radiation self damage in "2"4"1Am metal

AISI 316L stainless steel was welded by the electron beam (EB) and laser techniques. Microstructural characteristics, hardness profile, creep rupture properties and creep damage of the welds were investigated. Fully austenitic microstructure was obtained in the two welds. The solidification structure of the welds consisted of the cellular and equiaxed dendrites. The creep rupture lives of the two welds were almost the same, and they were reduced by a factor of about two compared to the base metal. Moreover, the rupture elongation of the welds was lower than that of the base metal. Creep damage was observed in the ''parting'' region of the welds and in the heat-affected zone (HAZ), respectively. Final creep fracture occurred in the ''parting'' region of the welds. (orig.).

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Helium-assisted cavity formation in ion-irradiated ceramics

The Moessbauer emission spectrum of "2"4"1Am metal was investigated for influences of radiation self damage. Samples were kept continuously for 230 h at 4.2 K and spectra were taken each 10 to 20 h. No change in f-factor was observed, while the linewidth increased monotonically and reached saturation after approximately 180 h. The original width could be reproduced by a brief warming to room temperature. The increase in width reflects the change in quadrupole interaction due to the creation of lattice defects. The constancy of the f-factor indicates that the basic crystalline structure is retained.

442

Gouge initiation in high-velocity rocket sled testing

Polycrystalline specimens of spinel (MgAl_2O_4) and alumina (Al_2O_3) were irradiated at room temperature and 650deg C with either dual- or triple-ion beams in order to investigate the effects of simultaneous displacement damage and helium implantation on cavity formation. The cavities in alumina were aligned along the direction of the c-axis, with diameters ranging from < 2 to 10 nm. The cavities in spinel were preferentially associated with dislocation loops and were of similar size as the cavities in alumina. Catastrophic amounts of cavitation were observed at the grain boundaries in spinel when the displacement damage level exceeded a critical value (#approx =# 20 dpa) in the presence of a fusion-relevant (#approx =# 60 appm/dpa) helium environment. (orig.).

1989-12-04

443

Gear crack level identification based on weighted K nearest neighbor classification algorithm

A model is presented which describes the formation of surface damage ``gouging`` on the rails that guide rocket sleds. An unbalanced sled can randomly cause a very shallow-angle, oblique impact between the sled shoe and the rail. This damage phenomenon has also been observed in high-velocity guns where the projectile is analogous to the moving sled shoe and the gun barrel is analogous to the stationary rail. At sufficiently high velocity, the oblique impact will produce a thin hot layer of soft material on the contact surfaces. Under the action of a normal moving load, the soft layer lends itself to an anti-symmetric deformation and the formation of a ``hump`` in front of the moving load. A gouge is formed when this hump is overrun by the sled shoe. The phenomenon is simulated numerically using the CTH strong shock physics code, and the results are in good agreement with experimental observation.

1994-07-01

444

British Library Electronic Table of Contents (United Kingdom)

A crack fault is one of the damage modes most frequently occurring in gears. Identifying different crack levels, especially for early cracks is a challenge in gear fault diagnosis. This paper aims to propose a method to classify the different levels of gear cracks automatically and reliably. In this method, feature parameters in time domain, specially designed for gear damage detection and in frequency domain are extracted to characterize the gear conditions. A two-stage feature selection and weighting technique (TFSWT) via Euclidean distance evaluation technique (EDET) is presented and adopted to select sensitive features and remove fault-unrelated features. A weighted K nearest neighbor (WKNN) classification algorithm is utilized to identify the gear crack levels. The gear crack experime...

2009-01-01

445

GaAs pattern etching with little damage by a combination of Ga"+focused-ion-beam irradiation and subsequent Cl_2 gas etching

GaAs pattern etching with little damage by a combination of Ga sup + focused-ion-beam irradiation and subsequent Cl sub 2 gas etching

Pattern formation on GaAs by Ga"+ focused-ion-beam (FIB) irradiation and subsequent Cl_2 gas etching was carried out. A higher etch rate at the FIB-irradiated area compared with that not irradiated under Cl_2 gas allows pattern construction without a mask process. The degree of residual crystal damage was evaluated using photoluminescence (PL) intensity measurements. The PL intensity in the etched region was one order of magnitude stronger than that of FIB sputtering, and was several times stronger than that of Ga"+ FIB-assisted Cl_2 etching. Etch depths of the order of 100 nm, which is five times deeper than that obtained by FIB sputtering, were efficiently performed using moderate Ga"+-ion doses.

446

Fente mediane cervicomaxillaire inferieure : a propos d'un cas, mise au point ethiopathogenique et therapeutique

Pattern formation on GaAs by Ga{sup +} focused-ion-beam (FIB) irradiation and subsequent Cl{sub 2} gas etching was carried out. A higher etch rate at the FIB-irradiated area compared with that not irradiated under Cl{sub 2} gas allows pattern construction without a mask process. The degree of residual crystal damage was evaluated using photoluminescence (PL) intensity measurements. The PL intensity in the etched region was one order of magnitude stronger than that of FIB sputtering, and was several times stronger than that of Ga{sup +} FIB-assisted Cl{sub 2} etching. Etch depths of the order of 100 nm, which is five times deeper than that obtained by FIB sputtering, were efficiently performed using moderate Ga{sup +}-ion doses.

1990-12-15

447

British Library Electronic Table of Contents (United Kingdom)

Introduction: The orofacial clefts include 30 variant according to Tessier classification: the number 30 contain mandibular arc damage isolated or associated with damage of surrounding soft tissue. Case report: Our patient was a newborn with median mandibular cleft associated with ankyloglossia, bifid tongue and a top cervical fistula. We have not found polymalformative syndrome. The early surgical management included one time and after-effect were simple within 11months. Discussion: We point up difficulties for antenatal diagnosis and controversy about appropriate time for management of bone defect. The last physiopathologic hypotheses were explicated.

2011-01-01

448

Embryo-damage induced nucleation of microcracks in an aluminum alloy under impact loading

Effects on focused ion beam irradiation on MOS transistors

The nucleation of microdamage under dynamic loading was investigated through planar impact experiments accomplished with a light gas gun. The microscopic observation of recovered and sectioned specimens showed that microcracks were nucleated only by cracking of brittle particles inside material. However, for comparison the in situ static tensile tests on the same material conducted with a scanning electron microscope showed that the microcracks were nucleated by many forms those were fracture of ductile matrix, debonding particles from matrix and cracking of brittle particles. The quantitative metallographic observations of the specimens subjected to impact loading showed that most of the cracked particles were situated on grain boundaries of the aluminum matrix. These facts suggested the concept of critical size and incubation time of submicroscopic cavities in the dynamic case and the mechanism of embryo-damage induced nucleation by fracture of brittle particles ...

1995-06-01

449

Deep-level defects and numerical simulation of radiation damage in GaAs solar cells

The effects of irradiation from a focused ion beam (FIB) system on MOS transistors are reported systematically for the first time. Three MOS transistor technologies, with 0.5, 1, and 3 {mu}m minimum feature sizes and with gate oxide thicknesses ranging from 11 to 50 nm, were analyzed. Significant shifts in transistor parameters (such as threshold voltage, transconductance, and mobility) were observed following irradiation with a 30 keV Ga{sup +} focused ion beam with ion doses varying by over 5 orders of magnitude. The apparent damage mechanism (which involved the creation of interface traps, oxide trapped charge, or both) and extent of damage were different for each of the three technologies investigated.

1997-04-01

450

Cooperative use of unmanned sea surface and micro aerial vehicles at Hurricane Wilma

A review of the deep-level defects observed in both electron- and proton-irradiated GaAs solar cells is presented. Studies of the effects of periodic and continuous thermal annealing on the radiation-induced electron and hole traps and the recombination parameters in GaAs solar cells were made for a wide range of electron and proton energies, fluence, annealing temperature and annealing time. A refined model for numerical simulations of the displacement damage was developed for computing the defect density and the cell parameters in the electron- and proton-irradiated GaAs solar cells. Excellent agreement was obtained between the calculated values and the experimental data for the proton-irradiated GaAs solar cells. (orig.).

1991-09-01

451

British Library Electronic Table of Contents (United Kingdom)

On Oct. 24, 2005, Hurricane Wilma, a category 5 storm, made landfall at Cape Romano, Florida. Three days later, the Center for Robot-Assisted Search and Rescue at the University of South Florida deployed an iSENYS helicopter and a prototype unmanned water surface vehicle, AEOS-1, to survey damage in parts of Marco Island, 14 km from landfall. The effort was the first known use of unmanned sea surface vehicles (USVs) for emergency response and established their suitability for the recovery phase of disaster management by detecting damage to seawalls and piers, locating submerged debris (moorings and handrails), and determining safe lanes for sea navigation. It provides a preliminary domain theory of postdisaster port and littoral inspection with unmanned vehicles for use by the human-robot ...

2008-01-01

452

Comparisons of the SCDAP computer code with bundle data under severe accident conditions

Chronic irradiation and brain development. Final (4th) progress report

The SCDAP computer code, which is being developed under the sponsorship of the United States Nuclear Regulatory Commission, models the progression of light water reactor core damage including core heatup, core disruption and debris formation, debris heatup, and debris melting. SCDAP is being used to help identify and understand the phenomena that control core behavior during a severe accident, to help quantify uncertainties in risk assessment analysis, and to support planning and interpretation of severe fuel damage experiments and data. Comparisons between SCDAP calculations and the experimental data showed good agreement. Calculated and measured bundle temperatures for SFD-ST were within 200 K for the entire bundle and within 20 K for maximum cladding temperatures. For ESSI-2, calculated and measured maximum cladding temperatures were within 50 K, and the extensive liquefaction and relocation that was calculated was in agreement with ...

1983-08-22

453

Characterization of physically vapor deposited AF2400 thin films

The possible long term effects of chronic radiation exposure have been studied. Rats were given tritiated drinking water (3#mu#Ci/ml) before pregnancy, during pregnancy and threafter, continuously through 5 generations. The brains were studied at 30 and 120 days postnatally. Significant decreases in weight, DNA and protein contents of specific parts of the brain were found, the most pronounced decreases being in the diencephalon. The decreases in protein content were more pronounced than the decreases in DNA content; the decreases were also more pronounced at 30 days than at 120 days, and more pronounced in the fifth generation than in previous generations. An attempt was made to explain these complex phenomena on the basis of known periods of proliferation of various brain cells, damage to mothers themselves in each generation, and damage and repair of nucleic acids caused by radioactivity.

454

Characteristics of radiation-induced neoplastic transformation in vitro

Anti-reflective coatings made with Teflon AF2400 had the highest damage thresholds recorded for physical vapor deposited coatings at the Lawrence Livermore National Laboratory damage facility. Physical vapor deposited layers of Teflon AF2400, a perfluorinated amorphous polymer, maintained the bulk optical properties of a high transmittance from 200 nm to 1600 nm, and a low refractive index. In addition, the refractive index can be intentionally reduced by control of two common deposition parameters, deposition rate and substrate temperature. Scanning electron microscopy and nuclear magnetic resonance observations indicated that morphological changes caused the variations in the refractive index rather than compositional changes. The coatings adhered to fused silica and silicon wafers under normal laboratory handling conditions.

1993-11-01

455

Cavitation erosion of advanced ceramics in water

Data are presented to support the hypothesis that the initial step in the morphologic transformation of irradiated rodent (BALB/3T3) cells is a frequent cellular event involving a large fraction of the irradiated population. This process appears to involve DNA damage, but not to represent a targeted mutation in specific structural gene(s). Morphologic transformation and immortalization appear to be distinct steps in the overall process of transformation. In contradistinction to rodent cells, immortalization is a very rare event in human diploid cells which is induced at extremely low frequencies. The hypothesis is presented that immortality develops among clones of cells bearing stable chromosomal rearrangements which emerge during the proliferation of a population of radiation damaged cells.

1986-01-01

456

Biochemical basis of circadian rhythms and diseases: With emphasis on post-traumatic stress disorder

The performance of advanced ceramics under cavitation loading in distilled water was studied by using a laboratory test with vibration-induced cavitation following the pattern of the ASTM standard G32-92. The hardened and tempered martensitic steel 100Cr6 was used as a reference. The aim was to identify mechanisms and the effects of important microstructural parameters on damage of polished Al{sub 2}O{sub 3}, Al{sub 2}O{sub 3}-ZrO{sub 2}, ZrO{sub 2} and SiC ceramics. Results showed that surface damage of brittle ceramics was mainly dominated by intergranular fracture, followed by detachment of single grains or fragments of them. Both incubation time and erosion rate were affected by the amount of initial surface cavities, grain sizes and secondary phases at grain boundaries. (orig.)

2006-10-15

457

British Library Electronic Table of Contents (United Kingdom)

Circadian rhythms affect several processes in the body physiology. This commentary revisits the topic of `metabolic basis of diseases' with a view to shed light on how cellular energy requirements feed-forward to a sequential signaling of hormonal response, blood glucose metabolism, antioxidant activities, and pathophysiology. Attempt is made to explain how diseases that may not appear to be closely related, such as bone metabolism and vasculopathy, have an increase in oxidative damage as a common underlying biochemistry. Importantly, this article identifies oxidative damage as an outcome of sleep disturbance and hypothesize that sleep complaint is not merely one of many resulting symptoms of PTSD, but a core feature that arise from trauma and gives rise to the stress biochemistry, which i...

2011-01-01

458

Analysis of thermoluminescence glow curves of minerals sphene and epidote for radiation damage studies

Analysis of installation damage tests for LRFD calibration of reinforced soil structures

Thermoluminescence (TL) properties of sphene and epidote are of interest in studies related to their radiation damage. Natural and artificially induced TL of these minerals has, therefore, been investigated. Both minerals exhibit complex glow curves with several overlapping peaks. The Tsub(m) -Tsub(STOP) thermal cleaning procedure has revealed three peaks in the ..gamma.. ray induced glow curve of each mineral. That these peaks obey second order kinetics was indicated by the continuously slanting structure of the Tsub(m)-Tsub(STOP) curve. The TL parameters E and s have been calculated using (i) the initial rise method, and (ii) the glow-peak shape method. In general, the values of E calculated by the first method are found to be higher than those from the second. The TL curve-fitting method is also applied in order to calculate these parameters and to serve as a cross-check on the results.

1986-01-01

459

British Library Electronic Table of Contents (United Kingdom)

North American design codes are now committed to the development of load and resistance factor design (LRFD) for reinforced soil structures including internal stability limit states. Reliability-based analysis is required to carry out these calibrations. A framework for LRFD calibration has been proposed by the writers that requires bias statistics for load and resistance terms for each limit state function. In this paper the formulation of the limit state for reinforcement tensile rupture is developed and the component strength-reduction bias statistics identified. The paper describes how to compute bias statistics from project-specific installation damage trials for use in reliability-based design for the reinforcement rupture limit state or using data from multiple sources for LRFD cali...

2011-01-01

460

A radiation hardening model of 9%Cr-martensitic steels including dpa and helium

British Library Electronic Table of Contents (United Kingdom)

This paper provides a physically-based engineering model to estimate radiation hardening of 9%Cr-steels under both displacement damage (dpa) and helium. The model is essentially based on the dispersed barrier hardening theory and the dynamic re-solution of helium under displacement cascades but incorporating a number of assumptions and simplifications [Trinkaus, J. Nucl. Mater. 318 (2003) 234-340]. As a result, the kinetics of the damage accumulation kept fixed, its amplitude is fitted on one experimental condition. The model was rationalized on an experimental database that mainly consists of 9%Cr-steels irradiated in the range of 50-600degreeC up to 50dpa and with a He-content up to 5000appm. The test temperature effect is taken into account through a normalization procedure based on the...

2009-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

A multidimensional hybrid intelligent method for gear fault diagnosis

British Library Electronic Table of Contents (United Kingdom)

Identifying gear damage categories, especially for early faults and combined faults, is a challenging task in gear fault diagnosis. This paper proposes a new multidimensional hybrid intelligent diagnosis method to identify different categories and levels of gear damage automatically. In this method, Hilbert transform, wavelet packet transform (WPT) and empirical mode decomposition (EMD) are performed on gear vibration signals to extract additional fault characteristic information. Then, multidimensional feature sets including time-domain, frequency-domain and time-frequency-domain features are generated to reveal gear health conditions. Multiple classifiers based on several classification algorithms and input features are combined with genetic algorithm (GA). Because of the use of multidim...

2010-01-01

462

Non cardiopatic and cardiopatic beta thalassaemic patients: quantitative and qualitative cardiac iron deposition evaluation with MRI; Pazienti {beta} talassemici non cardiopatici e cardiopatici: valutazione quantitativa e qualitativa del deposito di ferro cardiaco con RM

Test of superconducting Nb/Al bilayers as particle detectors

Purpose: Cardiomyopathy is one of the major complications of {beta} thalassaemia major as a result of transfusion iron overload. The aim of our study is to evaluate with MR if there is any difference of iron deposition signal intensity (SI) or distribution between non-cardiopatic and cardiopatic thalassaemic patients in order to establish if there is a relationship between cardiopathy and iron deposition. Materials and methods: We studied 20 patients affected by {beta} thalassaemia major, of whom 10 cardiopatic and 10 non-cardiopatic, and 10 healthy volunteers as control group. Serum ferritin and left ventricular ejection fraction were calculated in thalassaemic patients. All patients were examinated using a 1.5 MR unit with ECG-gated GE cine-MR T2*-weighted, SE T1-weighted and GE T2*-weighted sequences. In all cases, using an adequate ROI, the myocardial and skeletal muscle signal intensity (SI), the myocardial/skeletal muscle signal intensity radio (SIR) and the SI average of the ...

2005-02-01

463

Supported soft material compensators for combined gas and steam turbine power stations. Gestuetzte Weichstoff-Kompensatoren fuer Gas-Dampfturbinen-Kombi-Block-Kraftwerke

Superconducting thin film particle detectors can be very attractive due to the low sensitivity to radiation damage. We describe the fabrication procedure and the characterization of Nb/Al bilayers as particle detectors. First steady and dynamical results are reported from tests of 5 MeV alpha-particle detection.

2000-04-07

464

Statistical characterization of pitting corrosion process and life prediction

In combined cycle turbine power stations, soft material compensators are used which, if the full pressure fails, also withstand a small external pressure. Innovative forms of construction which guarantee useful life, are presented in relation to the design. Damaging effects, which limit the life of these special soft material compensators, are discussed. (orig.)

1994-09-01

465

Significance of cranial computer tomography for the early diagnosis of peri- and postnatal damage

In order to prevent corrosion failures of machines and structures, it is desirable to know in advance when the corrosion damage will take place, and appropriate measures are needed to mitigate the damage. The corrosion predictions are needed both at development as well as operational stage of machines and structures. There are several forms of corrosion process through which varying degrees of damage can occur. Under certain conditions these corrosion processes at alone and in other set of conditions, several of these processes may occur simultaneously. For a certain type of machine elements and structures, such as gears, bearing, tubes, pipelines, containers, storage tanks etc., are particularly prone to pitting corrosion which is an insidious form of corrosion. The corrosion predictions are usually based on experimental results obtained from test coupons and/or field experiences of similar machines or parts of a ...

466

Risk-orientated analysis of the SNR 300. Technical report 1

It is reported on examination-technical possibilities with craniocerebral Computer Tomography in the peri- and postnatal period. Some typical tomographic images from a 17 1/2 months period in our own patient material of 327 children are demonstrated. The special advantages of this new technical-extensive method are: exact diagnoses, observation possibility of the longitudinal section, and the absolute harmlessness to the child.

1981-01-01

467

Risk orientated analysis of the SNR 300

The study required by the West German Ministry of Research and Technology (RS 605) for the Committee on 'Future Nuclear Energy Policy' of the 9th German Parliament is concerned with the following main points: 1) Assessment of technical risks from the social aspect; 2) Discussion of terms and quantification of risks; 3) 'Engineering judgment' and 'questionable' methods in the Fast Breeder analysis of the Society for Reactor Safety (GRS); 4) Assessment criteria of potential damage. (HP).

468

Risk analysis for the SNR-300 project. Pt. 1. Risikoorientierte Analyse zum SNR 300. T. 1

To make a quantitative comparison of risks between the SNR 300 and a modern PWR (Biblis B), the consequences of an accident or the extent of damage of a release of radionuclides to the environment due to an accident are estimated by computer programs for accident consequence models. The accident analysis includes an analysis of events for Bethe-Tait accidents with failure of the outer containment. The FGSB release rates are compared with those of the Society for Reactor Safety (GRS). (HP).

469

Risk analysis for the SNR-300 project. Pt. 1

The volume contains reports on plant technology, on systems organisation with the aim to minimize the risk (human error), on the problem of seismic risk, on core-disruptive accidents and on accident consequence models with different release categories and a comparison of the potential damage incurred. Mr. Webb; one of the authors, attempts to disprove the objections to his two earliest SNR statements by experts of Karlsruhe Nuclear Research Centre.

1982-01-01

470

Repowering and retrofits: building on past value

The volume contains reports on plant technology, on systems organisation with the aim to minimize the risk (human error), on the problem of seismic risk, on core-disruptive accidents and on accident consequence models with different release categories and a comparison of the potential damage incurred. Mr. Webb; one of the authors, attempts to disprove the objections to his two earliest SNR statements by experts of Karlsruhe Nuclear Research Centre. (AK).

471

Radiation damage on amorphous metals. [Helium ion, neutron and gamma ray irradiation

Amidst the explosion of greenfield natural gas-fired combined-cycle plant development, opportunities still exist for valuable plant repowering and retrofits by taking advantages of unique technical and market conditions. One of the projects discussed is the rebuilding of the coal-fired Hawthorne unit 5 damaged by a boiler explosion. 3 tabs., 5 photos.

2000-01-01

472

Pulmonary damage caused by cytostatics and paraquat

The structural variations of amorphous metals, such as Pd/sub 80/Si/sub 20/, with irradiation of helium ion, neutron, and gamma ray have been mainly pursued by the method of X-ray diffraction and thermal analysis. It should be noticed that the amorphous metals show a radiation resistance, that is, no remarkable structural changes under helium ion, neutron, and gamma ray irradiation.

1982-04-01

473

Physical modeling of flow control device test in intake structure

Substances which exercise a pulmonary toxic action will first of all produce alveolar and perivascular oedemas followed by fibrosis. Differential diagnosis is explained on the basis of two cases of a fatal mitomycin fibrosis of the lung, as well as the observation of fibrous changes following the administration of Bleomycin and Metothrexat. The course of pulmonary fibroses caused by paraquat is described for two cases of fatal paraquat intoxications. (orig.).

474

PI3K/Akt and mTOR/p70S6K Pathways Mediate Neuroprotectin D1-Induced Retinal Pigment Epithelial Cell Survival during Oxidative Stress-Induced Apoptosis

The seawater in the intake structure flows into the large pump to with draw excess heat from the turbine steam condenser. In the intake structure of a nuclear power plant, undesirable pump operating characteristics such as vortices, impeller damages and non-uniform pump-approach flow around the pump bells take place frequently due to poorly-arranged intake geometry. In this study, physical modeling test was performed to predict the hydraulic phenomenon, and proposed flow control devices.

2000-05-01

475

Optimal design of perforating completion for gas well

The initiation and progression of several forms of retinal degenerations involve excessive, repetitive, and/or sustained oxidative stress that, in turn, mediate photoreceptor cell damage and...Full Text Available

2010-06-01

476

Nonlinear air-coupled emission: The signature to reveal and image microdamage in solid materials

The productivity characteristics of perforated gas well are investigated for the first time under real conditions considering drilling damage, perforation compacted zone and anisotropy in this paper. A non-linear finite element model for non-Darcy flow in perforated gas reservoir is built to consider the effects of twelve factors on productivity ratio (PR) of perforated gas well. The nomographs for two cases are presented in this paper. Compared with previous works, the following results are found: (1) the effects of drilling damage and perforation diameter on PR of gas well are more remarkable than that in oil well; (2) any perforation phase may be the best or the worst as to perforating gas well, which depends on anisotropy, drawdown and that whether or not perforations are beyond drilling damage zone; (3) the increase in perforation length hardly improve PR of gas well when perforations have been beyond drilling ...

1995-10-01

477

Neural classifier construction using regularization, pruning and test error estimation.

It is shown that low-frequency elastic vibrations of near-surface planar defects cause high-frequency ultrasonic radiation in surrounding air. The frequency conversion mechanism is concerned with contact nonlinearity of the defect vibrations and provides efficient generation of air-coupled higher-order ultraharmonics, ultrasubharmonics, and combination frequencies. The nonlinear air-coupled ultrasonic emission is applied for location and high-resolution imaging of damage-induced defects in a variety of solid materials.

2007-12-17

478

Ionising radiation. Part 2

In this paper we propose a method for construction of feed-forward neural classifiers based on regularization and adaptive architectures. Using a penalized maximum likelihood scheme, we derive a modified form of the entropic error measure and an algebraic estimate of the test error. In conjunction with optimal brain damage pruning, a test error estimate is used to select the network architecture. The scheme is evaluated on four classification problems. PMID:12662736

1998-12-01

479

Investigation into the fatigue behaviour of wood laminates for wind energy converter blade design

A brief tutorial on the health effects of ionising radiation is presented. The distinction between somatic and genetic health effects is explained. The two types of somatic health effects, i.e., acute and chronic effects, are discussed, as well as the concepts of ''deterministic'' and ''stochastic'' (also called ''probabilistic'') health effects. The possibility of cancer caused by DNA damage is discussed. The document ends with the definition of some key radiation terms.

2000-11-01

480

Influence of irradiation spectrum and implanted ions on the amorphization of ceramics

A thesis is presented on improving the understanding of the fatigue properties of wood and fatigue failure mechanisms in the design of wind turbine blades. Three main areas were researched: the effect of R ratio on fatigue life, the effect of moisture on fatigue life and the development of cumulative damage laws. Tests were carried out on mainly four-ply laminates. Recommendations to future work are outlined. (U.K.).

1987-01-01

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481

Impurity and clustering effects on defect evolution in ion-implanted Si

Polycrystalline Al2O3, magnesium aluminate spinel (MgAl2O4), MgO, Si3N4, and SiC were irradiated with various ions at 200-450 K, and microstructures were examined following irradiation using cross-section TEM. Amorphization was not observed in any of the irradiated oxide ceramics, despsite damage energy densities up to {similar_to}7 keV/atom (70 displacements per atom). On the other hand, SiC readily amorphized after damage levels of {similar_to}0.4 dpa at room temperature (RT). Si3N4 exhibited intermediate behavior; irradiation with Fe{sup 2+} ions at RT produced amorphization in the implanted ion region after damage levels of {similar_to}1 dpa. However, irradiated regions outside the implanted ion region did not amorphize even after damage levels > 5 dpa. The amorphous layer in the Fe-implanted region of Si3N4 did not appear if the specimen was simultaneoulsy irradiated with 1-MeV He{sup +} ions at ...

1995-12-31

482

Hypotheses on forest decline as reflected by the results of surveys

A detailed investigation of the damage formation and evolution in ion-implanted crystalline Si is presented. Deep-level transient spectroscopy has been used to monitor room temperature migration of point defect complexes and evolution from simple point-like defect complexes to defect clusters and even extended defects. Si samples were implanted with Si or He ions with energies of 145 keV-3MeV, to fluences in the range 5x10[sup 8]-5x10[sup 13]cm[sup -2]. The effects of thermal annealing, in the range 100-680 C and 10 min-15h, were also explored. A systematic comparison of defect complexes formation and evolution in ion-implanted or electron-irradiated Si samples with a different impurity content were used to assess the role of impurities (C and O), extra implanted ion and defect clustering on the nature and thermal stability of residual damage. In particular, an interstitial excess directly resulting from the extra implanted ion is shown to ...

1998-10-01

483

Harm to the cell and harm to the individual

With reference to three hypotheses on the causes of forest decline, the manifold uses of forest decline surveys are demonstrated. Hypothesis no. 1: Forest disease from high-voltage transmission lines; hypothesis no. 2: Forest disease as the consequence of damage from micorrhizas; hypothesis no. 3: Radioactivity as the cause of the increased incidence of forest disease. (orig./MG)

1987-11-25

484

Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region

Exposures from most natural and artificial sources, with the exception of those from medical radiology, are received at average dose rates of only a few microsieverts a day. Such risks as may be caused by these exposures are most unlikely to be determined with precision directly by epidemiological studies of populations exposed at these low rates. They may, however, be reliably inferred from the observed risks of exposure to rather larger doses delivered at higher dose rates in the light of the increasing knowledge of the phenomena involved in the initial cellular damage, the extent to which such damage is incorrectly repaired, and the processes which intervene between the genetic or other harm to cells and the likelihood of its final expression in inherited abnormality, in cancer development, or in defective foetal or embryonic growth. Current studies are of great importance, therefore, in examining the circumstances in which coding sections ...

1983-04-11

485

Final Report: Planetary Instrument Definition and Design Program (PIDDP) Support Project

Oxidized DNA bases, particularly 7,8-dihydro-8-oxoguanine (8-oxoG), are endogenously generated in cells, being a cause of carcinogenic mutations and possibly interfering with gene expression. We found...Full Text Available

2010-07-01

486

Fast cooling of steam turbines. Schnellabkuehlen von Dampfturbinen

The results of Sandia National Laboratories' participation in the NASA Planetary Definition and Design Program are summarized. Areas reported include the characterization of large area cadmium zinc telluride spectrometers and the application of simulation techniques to the prediction of device performance. Also investigated was the response of mercuric iodide devices in the region from 1 to 100 KeV. A literature study to determine the status or radiation damage measurements in room temperature semiconductor devices is also reported.

1999-03-01

487

Dounreay: an alternative development

Due to the fast cooling of steam turbines, the shutdown time during maintenance or when repairing faults and damage can be shortened. This booklet describes various processes for cooling steam turbines. It is recommended that fast cooling should be planned in designing new plants and corresponding arrangements should be provided in the form of pipe connections and valves. (DG).

1987-01-01

488

Differences in sensitivity of Schistosoma mansoni schistosomula, Dirofilaria immitis microfilariae, and Nematospiroides dubius third-stage larvae to damage by the polyamine oxidase-polyamine system.

With the Government decision to phase out the Fast Reactor at Dounreay there is a need to find alternative employment in the area. Traditionally Caithness is an area of farming, fishing and tourism which could be damaged if Dounreay were to be made a nuclear waste repository. The suggestion is that Dounreay should become a centre for research, development and subsequent manufacture of renewable energy sources and devices to harness renewable energy. The Scottish coastline has potential for wind and wave power developments and this could lead to a whole industry in the future. (UK).

1991-01-01

489

Descriptive study of damage caused by the rhinoceros beetle, Oryctes agamemnon, and its influence on date palm oases of Rjim Maatoug, Tunisia.

The effect of the polyamine oxidase (PAO)-polyamine system on some helminths was examined in vitro. Both Schistosoma mansoni schistosomula and Dirofilaria immitis microfilariae were highly sensitive...Full Text Available

1986-09-01

490

Deletion of Genes Implicated in Protecting the Integrity of Male Germ Cells Has Differential Effects on the Incidence of DNA Breaks and Germ Cell Loss

Oryctes agamemnon (Burmeister 1847) (Coleoptera, Scarabaeidae) was accidentally introduced in the southwestern oases of Tunisia (Tozeur) around 1980 and spread to the Rjim Maatoug region. In these areas O. agamemnon was specific to date palm trees causing severe damage that can result in potential danger due to collapse of the tree. This study was conducted from April 2004 to March 2006 in 4 sites in the region of Rjim Maatoug. Different levels of palm tree attack were determined, ovioposition sites were identified, and pest damage was described in detail to specify their relative importance and to indicate factors governing palm tree attack. Eggs were individually oviposited in the attacked parts. Dead parts of palm trees were the main target of O. agamemnon including the respiratory roots, tough, trunk bark, dry petiole and the periphery of the crown. The crown itself was not attacked. Feeding by larvae caused significant ...

2008-01-01

491

Damages of mountings in HP- and MP-turbines; Schaeden an Vierzacken-Schaufelfuessen in HD- und MD-Turbinen

BackgroundInfertility affects ∼20% of couples in Europe and in 50% of cases the problem lies with the male partner. The impact of damaged DNA originating...Full Text Available

492

Condenser replacement at Unterweser nuclear power station

Investigation of an HP-blade damage in 1996 and an MP-blade damage in 1007 at the mounting showed that fretting and creep fatigue had caused the damage. Break-down occurred when creep-related cracks developed between radial bridge to the upper blade tooth and weight relief boreholes. After disassembly of the HP-blades the lower blade tooth was found to be cracked after fretting (some cracks along the whole length of the tooth). The lower teeth of MP-bladedes showed merely superficial cracks (depth about 0.4mm). The massive cracks of the lower blade tooth were caused by instationary clearance changes combined with hard blade underground.(orig.) [German] Das Ergebnis der Untersuchung nach einem HD-Schaufelschaden 1996 sowie einem MD-Schaufelschaden 1997 an der Vierzackenfussbefestigung ergab Zeitstanderschoepfung und Fretting als auszuloesende Schadensmechanismen. Die Havarien wurden durch zeitstandbedingte Brueche zwischen ...

1998-07-01

493

In spite of extensive cooling water studies premature damage due to corrosion occurred on the CuZn20Al condenser tubes. It was then decided to incorporate new titanium-tubed condensers during the annual overhauls of 1983 and 1985 and also take ameliorating measures up to the exchange of individual condensers. (orig.).

494

Commentary

Cluster-loop structure influence on molybdenum radiation hardening

1. It is not possible to give a threshold value for the dose - nor for genetic neither for somatic late effects. 2. The linear dose-effect exprapolation is not conservative in the sense of 'fying on the safe side'. 3. There has been found no relative reduction of the effects at chronic radiation exposure in man. 4 The numbers given by authorities and utilities for damage rates per rem received, that are called upper limits, are by far too low. (orig./HP).

1980-02-01

495

Catalyst: Dietary Supplements - ABC TV Science

Results on defect structure study and degree of molybdenum radiation hardening irradiated by fission neutrons and medium energy alpha-particles are presented. It is shown that molybdenum irradiation by alpha-particles and neutrons leads to different degree of material hardening for the same damage level. It is established that molybdenum radiation hardening is mainly defined by radiation defect clusters visible in electron microscope whose coefficient of rigidity depends on their size. 5 refs.; 6 figs.; 2 tabs. (author).

1990-05-22

496

Wastenet

... However blaming vitamin supplements on deaths, or mortality is silly, as the studies are not exactly kosher. Vitamin C in 2,000mg is good for allergies, and niacin (b3) in 10,0000mg is good for depression. This is all examples on how vitamin supplements can help. I call it a security blanket, as food these days is not so good due vitamin and mineral damage due to light, or storage. By the time we eat the apple from the supermarket, there is minimal vitamin and ...

497

CLIC High-Gradient Test Results

Boron uphill diffusion during ultrashallow junction formation

The CLIC (Compact Linear Collider) high-gradient RF structure testing program has been carried out in order to gain insight into the physical processes involved in RF breakdown, determine the mechanisms that limit gradient and produce damage so that technical concepts can be developed which allow higher accelerating gradients. Two main paths towards higher gradients have emerged from this program, and the performances of two new structures which incorporate them are presented.

2002-01-01

498

#alpha#-particle irradiation damage and stage I recovery in zinc

The recently observed phenomenon of boron uphill diffusion during low-temperature annealing of ultrashallow ion-implanted junctions in silicon has been investigated. It is shown that the effect is enhanced by preamorphization, and that an increase in the depth of the preamorphized layer reduces uphill diffusion in the high-concentration portion of boron profile, while increasing transient enhanced diffusion in the tail. The data demonstrate that the magnitude of the uphill diffusion effect is determined by the proximity of boron and implant damage to the silicon surface.

2003-05-26

499