d2 receptor status: Topics by WorldWideScience.org

Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys

Hormone potency depends on receptor availability, regulated via gene expression and receptor trafficking. To ascertain how central leptin receptors are regulated, the effects of leptin challenge, high-fat...Full Text Available

2009-07-15

3

Role of Obesity in Prostate Cancer Development

Dopamine (DA) D3 and D2 receptor mechanisms are implicated in cocaine's abuse-related behavioral effects, but the relative contribution of the two receptor subtypes is only partially characterized....Full Text Available

2010-08-01

4

ERG Expression Levels in Prostate Tumors Reflect Functional ...

... estrogen receptor status. Cancer Lett., 253, 291-300. 39. Xin,X ... and resistant mice. Brain Res.Bull., 52, 235-242. 40. Foster,BA ...

2011-04-01

5

Forkhead Box Transcription Factor FOXO3a Regulates Estrogen Receptor Alpha Expression and Is Repressed by the Her-2/neu/Phosphatidylinositol 3-Kinase/Akt Signaling Pathway

... Title : ERG Expression Levels in Prostate Tumors Reflect Functional Status of the Androgen Receptor (AR) as a Consequence of Fusion of ERG ...

6

Radiolabelled D_2 agonists as prolactinoma imaging agents: Progress report for period February 1, 1988--January 31, 1989

The expression status of the estrogen receptor alpha (ERα) and that of the epidermal growth factor receptor Her-2/neu frequently correlate inversely in breast cancers. While ERα-dependent...Full Text Available

2004-10-01

7

Synergistic epigenetic reactivation of estrogen receptor-? (ER?) by combined green tea polyphenol and histone deacetylase inhibitor in ER?-negative breast cancer cells

Targeted studies completed include the evaluation of tritiated N-0437, evaluation of "3"5S-cysteamine, evaluation of "1"8F-FDG and initiation of synthetic efforts towards the synthesis of iodinated N-0437 and pergolide analogs. The direction of the project has been changed due to several factors which include the decided lack of favorable experimental results, the excellence of results using muscarinic receptor ligands in pituitary, brain and heart and the contention of the DOE review panel that the original grant proposal was based on flawed assumptions together with their perceived lack of importance to pituitary imaging. In the final year of this grant, three studies will be completed. The first study is the continuation of synthetic efforts to prepare iodinated N-0437 and pergolide analogs for possible use as brain imaging agents. The second study is directed towards completion of biochemical evaluation of various muscarinic receptor ...

8

Preparation and radiolabeling of IBZM: a potential D-2 specific brain imaging agents for SPECT

BackgroundThe status of estrogen receptor-α (ERα) is critical to the clinical prognosis and therapeutic approach in breast cancer. ERα-negative breast cancer...Full Text Available

9

Novel photoaffinity label for the dopamine D2 receptor: synthesis of 4-azido-5-iodo-2-methoxy-N-1-(phenylmethyl)-4-piperidinyl benzamide (iodoazidoclebopride, IAC) and the corresponding "1"2"5I-labeled analogue ("1"2"5IAC)

In developing new receptor-site specific brain imaging agents labeled with I-123 for single photon emission computed tomography (SPECT), an analog of raclopride, 3-["1"2"5I]-iodo-N-[(1-ethyl-2-pyrrolidinyl)-methyl]-2-hydroxy-6-me-thoxy benzamide (IBZM), was prepared using a method similar to that reported for raclopride and its derivatives. (author).

10

... affinity azido compounds biosynthesis dopamine iodine compounds iodine

11

TOTEM Status Report

TOTEM Status Report

2011-01-01

12

LHCb Status report

LHCb Status report

2011-01-01

13

ALICE Status Report

Status of he-cooled divertor development (PPCS subtask TW4-TRP-001-D2)

ALICE Status Report

2011-01-01

14

Within the framework of the EU power plant conceptual study (PPCS), helium-cooled modular divertor concepts have been investigated in detail at the Forschungszentrum Karlsruhe during the past few years. The first conceptual design proposed was based on convective cooling with the use of flow promoters in the form of pin and/or slot arrays (HEMP/HEMS) to increase the cooling surface and, hence, enhance the heat transfer capacity. While continuing the design optimisation, an advanced multiple-jet design (HEMJ) was introduced, which is based on direct jet-to-wall impinging cooling and offers advantages in terms of simple construction and manufacturing. Main emphasis of the 2004 work program (TW4-TRP-001) lay on experiments for the concepts HEMJ and HEMS, which were mainly performed at the Efremov Institute in St. Petersburg, Russia. For experiment preparation, detailed test programs were worked out and accompanying CFD analyses were accomplished. The outcomes of experimental ...

15

Status report ANKE

The TofRoot project - status and perspectives

No abstract prepared.

2002-03-01

16

The structure of receptor-associated protein (RAP)

No abstract prepared.

2002-03-01

17

Structure and function of an acetylcholine receptor.

The receptor-associated protein (RAP) is a molecular chaperone that binds tightly to certain newly synthesized LDL receptor family members in the endoplasmic reticulum (ER) and facilitates their delivery...Full Text Available

2007-08-01

18

Structural analysis of an acetylcholine receptor from Torpedo californica leads to a three-dimensional model in which a "monomeric" receptor is shown to contain subunits arranged around a central ionophoretic...Full Text Available

1982-01-01

19

Orphan GPCR research

Bioengineered bugs expressing oligosaccharide receptor mimics

Orphan G protein-coupled receptors (GPCRs) are receptors lacking endogenous ligands. Found by molecular biological analyses, they became the roots of reverse pharmacology, in which receptors are attempted...Full Text Available

2008-03-01

20

AMPA-receptor trafficking and injury-induced cell death

Many microbial pathogens recognize oligosaccharides displayed on the surface of host cells as receptors for toxins and adhesins. These ligand-receptor interactions are critical for disease pathogenesis,...Full Text Available

2010-05-01

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ATHENA simulation of the Wolsung D_2O spill incident of 1984 November 25

AMPA receptors (AMPARs) are critical for synaptic plasticity, and are subject to alterations based on subunit composition and receptor trafficking to and from the plasma membrane. One of the...Full Text Available

2010-07-01

22

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation

Short communication.

1986-06-09

23

Intracellular delivery of an antisense?oligonucleotide via endocytosis of a G protein-coupled receptor

The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor that plays critical roles in bone and mineral ion metabolism. Ligand binding to the PTHR involves interactions to both...Full Text Available

2008-10-28

24

Expression of retinoic acid receptor beta in dermatofibrosarcoma protuberans.

Gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor superfamily, has been utilized for receptor-mediated targeting of imaging and therapeutic agents; here we extend...Full Text Available

2010-10-01

25

Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein.

PMID:19469866

2009-03-16

26

Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms

To study the effect of agonist on the TRH (thyrotrophin-releasing hormone) receptor protein, an epitope-tagged receptor was stably expressed in HEK-293 cells (human embryonic kidney 293 cells) and receptor...Full Text Available

2004-06-15

27

Radiolabelled D2 agonists as prolactinoma imaging agents

Acute Asthma

2011-05-24

28

Modulation of Retinoic Acid Receptor-related Orphan Receptor ? and ? Activity by 7-Oxygenated Sterol Ligands*

During the past year, further studies on mAChR were conducted. These studies included verification of the difference in pituitary distribution based on ligand charge. The pituitary localization of TRB. A neutral mAChR ligand, was verified. The lack of QNB blockade of TRB uptake was tested by blockage with scopolamine, another mAChR antagonist and by testing the effect in a different strain of rat. Neither scopolamine or change of rat strain had any effect. We concluded that TRB uptake in pituitary is not a receptor-mediated process. Further studies were conducted with an additional quaternized mAChR ligand: MQNB. Pituitary localization of MQNB, like MTRB, could be blocked by pretreatment with QNB. We have tentatively concluded that permanent charge on a mAChR antagonist changes the mechanism of uptake in the pituitary. Time course studies and the effects of DES on myocardial uptake are reported. A brief report on preliminary results of evaluation of quaternized ...

1989-08-01

29

Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: A concise update

The retinoic acid receptor-related orphan receptors α and γ (RORα (NR1F1) and RORγ (NR1F3)) are orphan nuclear receptors and perform critical roles in regulation of development,...Full Text Available

2010-02-12

30

Present status of containment integrity tests at NUPEC

The gastrin releasing peptide (GRP) receptor is becoming an increasingly attractive target for development of new radiolabeled peptides with diagnostic and therapeutic potential. The attractiveness of the GRP receptor as a target is based upon the functional expression of GRP receptors in several tumors of neuroendocrine origin including prostate, breast, and small cell lung cancer. This concise review outlines some of the efforts currently underway to develop new GRP receptor specific radiopharmaceuticals by employing a variety of radiometal chelation systems.

2003-11-01

31

Fast Flux Test Facility (FFTF) Background & Status

No abstract prepared.

2000-11-01

32

A SURVEY ON THE USING STATUS AND PERCEPTION OF PIT AND FISSURE SEALANT

No abstract prepared.

2001-06-01

33

The Pregnane X Receptor: From Bench to Bedside

Full Text Available

2009-02-01

34

Surface structure recognized for covalent modification of the aspartate receptor in chemotaxis.

BackgroundThe pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters involved...Full Text Available

2008-07-01

35

Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene

The aspartate receptor involved in chemotaxis is modified by methyl esterification at four distinct glutamate residues during the adaptive response of this receptor. To explain the high degree of specificity...Full Text Available

1986-09-01

36

Receptor Binding Sites and Antigenic Epitopes on the Fiber Knob of Human Adenovirus Serotype 3

Selective estrogen receptor modulators (SERMs) represent a class with a growing number of compounds that act as either estrogen receptor agonists or antagonists in a tissue-specific manner. This article...Full Text Available

2010-01-01

37

Lineage-specific co-evolution of the Egf receptor/ligand signaling system

The adenovirus fiber knob causes the first step in the interaction of adenovirus with cell membrane receptors. To obtain information on the receptor binding site(s), the interaction of labeled cell...Full Text Available

1998-11-01

38

Involvement of the chemokine-like receptor GPR33 in innate immunity?

BackgroundThe epidermal growth factor receptor (Egfr) with its numerous ligands has fundamental roles in development, cell differentiation and physiology. Dysfunction of the receptor-ligand...Full Text Available

39

Influence of atrial stretch receptors on hypothalamic neurosecretory neurones.

Chemokine receptors control leukocyte chemotaxis and cell-cell communication but have also been associated with pathogen entry. GPR33, an orphan member of the chemokine-like receptor family,...Full Text Available

2010-05-28

40

In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor

1. The effects of stimulation of atrial receptors on hypothalamic neurosecretory cells were investigated in anaesthetized dogs and cats. Atrial receptors were activated by stretching the left and the...Full Text Available

1978-12-01

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41

Immunoglobulins in myasthenia gravis. Kinetic properties of the acetylcholine-receptor antibody studied during lymph drainage.

The nicotinic acetylcholine receptor (AChR) controls signal transmission between cells in the nervous system. Abused drugs such as cocaine inhibit this receptor. Transient kinetic investigations indicate...Full Text Available

1998-11-24

42

Continuous monitoring of receptor-mediated changes in the metabolic rates of living cells.

A specific immunoglobulin, the receptor antibody, can be found in most patients with myasthenia gravis. In order to study the kinetic properties of this antibody, serial determinations of receptor antibody,...Full Text Available

1978-10-01

43

Construction of a novel bifunctional biogenic amine receptor by two point mutations of the H2-histamine receptor.

Activation of beta-adrenergic or muscarinic acetylcholine receptors expressed in transfected cells or epidermal growth factor receptors in human keratinocytes produces 15% to 200% changes in cellular...Full Text Available

1990-05-01

44

Changes in Androgen Receptor, Estrogen Receptor alpha, and Sexual Behavior with Aging and Testosterone in Male Rats1

BACKGROUND: H2-histamine receptors mediate a wide range of physiological functions extending from stimulation of gastric acid secretion to induction of human promyelocyte differentiation. We have previously...Full Text Available

1995-03-01

45

A Hot New Twist to Hair Biology

Reproductive aging in males is characterized by a diminution in sexual behavior beginning in middle age. We investigated the relationships among testosterone, androgen receptor (AR) and estrogen...Full Text Available

2010-07-01

46

Rapidly adapting receptors in a rabbit model of mitral regurgitation

The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers. TRPV1 was originally described on sensory neurons...Full Text Available

2005-04-01

47

New Developments in the Use of Histamine and Histamine Receptors

Unlike in normal rabbits, pulmonary rapidly adapting receptors (RARs) in rabbits with chronic mitral regurgitation (MR) do not respond to small changes in extravascular...Full Text Available

1999-12-15

48

Anesthetic stimulation of insect water receptors.

Histamine and the histamine receptors are important regulators of a plethora of biological processes, including immediate hypersensitivity reactions and acid secretion in the stomach. In these...Full Text Available

2011-04-01

49

VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL.

Halothane, chloroform, and carbon tetrachloride, in the vapor and liquid phases, stimulate the water receptor of the blowfly Phormia regina. There are three successive phases of response to long-lasting...Full Text Available

1976-09-01

50

The extracellular calcium sensing receptor is expressed in mouse mesangial cells and modulates cell proliferation.

PMID:21331648

2011-02-19

51

The Role of Opioid Receptor on the Analgesic Action of Intrathecal Sildenafil in Rats

Full Text Available

2005-10-01

52

Role of B2 Adrenergic Receptors in Labor Pain

Full Text Available

2007-06-01

53

Protease and protease-activated receptor-2 signaling in the pathogenesis of atopic dermatitis.

Pain; Pain Threshold; Labour Pain

2010-10-01

54

Naltrexone Inhibits Catecholamine Secretion Evoked by Nicotinic Receptor Stimulation in the Perfused Rat Adrenal Medulla

Full Text Available

2010-11-01

55

Inertial Dynamic Effect on the Rates of Diffusion-Controlled Ligand-Receptor Reactions

Full Text Available

2005-08-01

56

Effects of single or combined histamine H₁-receptor and leukotriene CysLT₁-receptor antagonism on nasal adenosine monophosphate challenge in persistent allergic rhinitis

Full Text Available

2011-08-01

57

Characterization of a Novel Small Molecule Subtype Specific Estrogen-Related Receptor ? Antagonist in MCF-7 Breast Cancer Cells

BackgroundThe effects of single or combined histamine H₁-receptor and leukotriene CysLT₁-receptor antagonism on nasal adenosine monophosphate (AMP) challenge...Full Text Available

2004-06-01

58

Limitation of immunohistochemical localization of estrogen receptor

BackgroundThe orphan nuclear receptor estrogen-related receptor α (ERRα) is a member of the nuclear receptor superfamily. It was identified through a search for genes...Full Text Available

59

Flue gas desulfurization pilot study. phase i. survey of major installations. report no. 95. summary of survey reports on flue gas desulfurization processes

Although the radioreceptor method is widely used for estrogen receptor assay in human tissue, it has several limitations and a number of alternative methods are being explored. An immunohistochemical method of estrogen receptor assay using a specific antibody to estradiol has been proposed as a suitable alternative. The present study was designed to evaluate the validity of this method in detecting true estrogen receptors in human tumor tissue. Using radioiodinated antibody to estrogen, we have demonstrated that the estrogen antibody can detect the estrogen when it is bound to 4S type receptor but is unable to bind to estrogen when the hormone is bound to 8S type receptor. Our observations suggest that the immunohistochemical method of detection of intracellular cytosolic receptor for estrogen is not a suitable alternative to the currently used radioreceptor ...

1986-10-01

60

Cloning and expression of a human kidney cDNA for an /alpha//sub 2/-adrenergic receptor subtype

Appendices to this summary consist of twelve individual status reports that will be available through the National Technical Information Service (NTIS) in the United States and of course limited copies will be available through NATO. The twelve report titles which are appendices to the summary are: (A) Status Report on the Limestone/Sludge Flue Gas Desulfurization Process; (B) Status Report on the Lime/Sludge Flue Gas Desulfurization Process; (C) Status Report on the Double Alkali/Sludge Flue Gas Desulfurization Process; (D) Status Report on the Sea Water Scrubbing Flue Gas Desulfurization Process; (E) Status Report on the Limestone/Gypsum Flue Gas Desulfurization Process; (F) Status Report on the Lime/Gypsum Flue Gas Desulfurization Process; (G) Status Report on the Double Alkali/Gypsum Flue Gas Desulfurization Process; ...

1979-01-01

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61

Internalized insulin-receptor complexes are unidirectionally translocated to chloroquine-sensitive degradative sites. Dependence on metabolic energy

An /alpha//sub 2/-adrenergic receptor subtype has been cloned from a human kidney cDNA library using the gene for the human platelet /alpha//sub 2/-adrenergic receptor as a probe. The deduced amino acid sequence resembles the human platelet /alpha//sub 2/-adrenergic receptor and is consistent with the structure of other members of he family of guanine nucleotide-binding protein-coupled receptors. The cDNA was expressed in a mammalian cell line (COS-7), and the /alpha//sub 2/-adrenergic ligand (/sup 3/H)rauwolscine was bound. Competition curve analysis with a variety of adrenergic ligands suggests that this cDNA clone represents the /alpha//sub 2/B-adrenergic receptor. The gene for this receptor is on human chromosome 4, whereas the gene for the human platelet /alpha//sub 2/-adrenergic receptor (/alpha//sub 2/A) lies on chromosome 10. This ...

1988-09-01

62

Infinite-parametric extension of the conformal algebra in D>2 space-time dimensions

Insulin receptors on the surface of isolated rat adipocytes were photoaffinity labeled at 12 degrees C with the iodinated photoreactive insulin analogue, 125I-B2 (2-nitro-4-azidophenylacetyl)-des-PheB1-insulin, and the pathways in the intracellular processing of the labeled receptors were studied at 37 degrees C. During 37 degrees C incubations, the labeled 440-kDa insulin receptors were continuously internalized (as assessed by trypsin inaccessibility) and degraded such that up to 50% of the initially labeled receptors were lost by 120 min. Metabolic poisons (0.125-0.75 mM 2,4-dinitrophenol (DNP) and 1-10 mM NaF), which led to dose-dependent depletion of adipocyte ATP pools, inhibited receptor loss, and caused up to 3-fold increase in intracellular receptor accumulation. This effect was due to inhibition of intracellular receptor ...

1988-04-25

63

Thermodynamic study of systems with lower critical solution temperatures: H_2O + (C_2H_5)_3N, D_2O + (C_2H_5)_3N

On the basis of the analytic continuations of semisimple Lie algebras discovered recently by us we construct manifestly quasiconformal infinite-dimensional algebras AC(so(4, 1)) and PAC(so(3, 2)) extending the conformal algebras in three-dimensional euclidean and Minkowski space-time like the Virasoro algebra extends so(2, 1). Their higher spin generalizations are also constructed. A counterpart of the central extension for D > 2 and possible appplications in exactly solvable conformal quantum field models in D > 2 are discussed. (orig.).

1991-01-01

64

Molecular targeted treatment and radiation therapy for rectal cancer

Molar excess enthalpies and molar excess volumes are reported for the systems H_2O + (C_2H_5)_3N and D_2O + (C_2H_5)_3N at temperatures below and above their lower critical solution temperatures. The molar excess enthalpies are slightly less exothermic for the D_2O system. The molar excess volumes of the H_2O and D_2O systems are within experimental error of one another. Compositions of conjugate solutions estimated from the calorimetric and volumetric measurements agree with those obtained from published liquid-liquid phase diagrams. (Auth.).

1979-01-01

65

Theoretical Basis of Protocols for Seed Storage

Background: EGFR (epidermal growth factor receptor) and VEGF (vascular endothelial growth factor) inhibitors confer clinical benefit in metastatic colorectal cancer when combined with chemotherapy. An emerging strategy to improve outcomes in rectal cancer is to integrate biologically active, targeted agents as triple therapy into chemoradiation protocols. Material and methods: cetuximab and bevacizumab have now been incorporated into phase I-II studies of preoperative chemoradiation therapy (CRT) for rectal cancer. The rationale of these combinations, early efficacy and toxicity data, and possible molecular predictors for tumor response are reviewed. Computerized bibliographic searches of Pubmed were supplemented with hand searches of reference lists and abstracts of ASCO and ASTRO meetings. Results: the combination of cetuximab and CRT can be safely applied without dose compromises of the respective treatment components. Disappointingly low rates of pathologic ...

2009-06-15

66

Deep donor states of muonium in silicon and germanium (status report exp SC81)

The protocols presently established for optimum seed storage do not account for the chemical composition of different seed species, the physiological status of the seed, and the physical status of water...Full Text Available

1990-11-01

67

Combustible Cartridge Cases: Current Status and Future ...

Deep donor states of muonium in silicon and germanium (status report exp SC81)

1979-01-01

68

GABAB Receptors Modulate NMDA Receptor Calcium Signals in Dendritic Spines

... 13BRL I COMBUSTIBLE CARTRIDGE CASES: CURRENT STATUS AND FUTURE PROSPECTS FW ROBBINS J. W. COLB3URN DI ...

1992-08-01

69

British Library Electronic Table of Contents (United Kingdom)

Summary Metabotropic GABAB receptors play a fundamental role in modulating the excitability of neurons and circuits throughout the brain. These receptors influence synaptic transmission by inhibiting presynaptic release or activating postsynaptic potassium channels. However, their ability to directly influence different types of postsynaptic glutamate receptors remains unresolved. Here we examine GABAB receptor modulation in layer 2/3 pyramidal neurons from the mouse prefrontal cortex. We use two-photon laser-scanning microscopy to study synaptic modulation at individual dendritic spines. Using two-photon optical quantal analysis, we first demonstrate robust presynaptic modulation of multivesicular release at single synapses. Using two-photon glutamate uncaging, we then reveal that GABAB r...

2010-01-01

70

Cloning of the cDNA and gene for a human D sub 2 dopamine receptor

Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans.

A clone encoding a human D{sub 2} dopamine receptor was isolated from a pituitary cDNA library and sequenced. The deduced protein sequence is 96% identical with that of the cloned rat receptor with one major difference: the human receptor contains an additional 29 amino acids in its putative third cytoplasmic loop. Southern blotting demonstrated the presence of only one human D{sub 2} receptor gene. Two overlapping phage containing the gene were isolated and characterized. DNA sequence analysis of these clones showed that the coding sequence is interrupted by six introns and that the additional amino acids present in the human pituitary receptor are encoded by a single exon of 87 base pairs. The involvement of this sequence in alternative splicing and its biological significance are discussed.

1989-12-01

71

Thermal analysis of spent fuel in rehearsal and emergency storage facility (RESF) under station blackout (SBO) in TAPS - 4

Prostaglandin (PG) D2 has been shown to be transformed by human 11-ketoreductase to 9 alpha,11 beta-PGF2, a biologically active metabolite that is produced in vivo. During the course of developing a...Full Text Available

1988-01-01

72

p53 mutation in breast cancer. Correlation with cell kinetics and cell of origin

The RESF is utilized for storage of spent fuel under emergency conditions as well as for testing of FM heads. It receives cooling supply from the PHT Pressurizing pumps and after removal of decay heat from the spent fuel it goes to the D2O Storage Tank. The geometry of the RESF system is such that it can not sustain the thermosyphon loop during SBO, due to high frictional forces. To achieve the sustained thermosyphon, modifications in the design were suggested viz., removal of the steam trap and the relief valve above it and replacement by a solenoid valve (SV-16). In the event of SBO, SV-16 will open on 'RESF channel temperature high' signal and connect to FT D2O tank. The tank, being at atmospheric pressure and at lower elevation, will provide higher cooling flow rate through the RESF channel. D2O is periodically removed from the FT ...

2006-11-13

73

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA_A receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster

Aim: Several studies have investigated the expression of the cytokeratins (CKs), vimentin, the epithelial growth factor receptor (EGFR), the oestrogen receptor (ER), and the progesterone...Full Text Available

2002-06-01

74

The Melanocortin 3 Receptor: A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?

The GABA-modulating and GABA-mimetic activities of the monoterpenoid thymol were explored on human GABA_A and Drosophila melanogaster...Full Text Available

2003-12-01

75

The Cytokinin Receptors of Arabidopsis Are Located Mainly to the Endoplasmic Reticulum¹^[W]^[OA]

The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 32.7 ± 3.7)...Full Text Available

76

The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor

The plant hormone cytokinin is perceived by membrane-located sensor histidine kinases. Arabidopsis (Arabidopsis thaliana) possesses three cytokinin receptors: ARABIDOPSIS HISTIDINE...Full Text Available

2011-08-01

77

T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells

BackgroundThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity and biological activity of dioxins and related chemicals. The...Full Text Available

78

Structure of Natural Killer Cell Receptor KLRG1 Bound to E-Cadherin Reveals Basis for MHC-Independent Missing Self Recognition

Epidermal growth factor receptor (EGFR)-specific monoclonal antibodies predominantly inhibit colorectal cancer (CRC) growth by interfering with receptor signaling. Recent analyses have shown that patients...Full Text Available

2010-07-13

79

Spontaneous expression of the interleukin 2 receptor gene and presence of functional interleukin 2 receptors on T lymphocytes in the blood of individuals with active pulmonary sarcoidosis.

SUMMARYThe cytolytic activity of natural killer (NK) cells is regulated by inhibitory receptors that detect the absence of self molecules on target cells. Structural studies of...Full Text Available

2009-07-17

80

Sodium/Calcium Exchangers Selectively Regulate Calcium Signaling in Mouse Taste Receptor Cells

Current concepts of the pathogenesis of sarcoidosis suggest that the expanded numbers of activated T-helper/inducer cells at sites of disease activity result, at least in part, from their proliferation...Full Text Available

1988-09-01

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81

Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and ?-adrenoceptors

Taste cells use multiple signaling mechanisms to generate appropriate cellular responses to discrete taste stimuli. Some taste stimuli activate G protein coupled receptors (GPCRs) that cause calcium...Full Text Available

2010-07-01

82

Sensitivity limits for voltage control of P2Y receptor-evoked Ca²⁺ mobilization in the rat megakaryocyte

The normal physiological contraction of the urinary bladder, which is required for voiding, is predominantly mediated by muscarinic receptors, primarily the M₃ subtype, with the M₂...Full Text Available

2008-06-01

83

Retinoic acid X receptor in the diploblast, Tripedalia cystophora

G-protein-coupled receptor signalling has been suggested to be voltage dependent in a number of cell types; however, the limits of sensitivity of this potentially important phenomenon are unknown. Using...Full Text Available

2004-02-15

84

Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

Nuclear hormone receptors comprise a characteristic family of transcription factors found in vertebrates, insects and nematodes. Here we show by cDNA and gene cloning that a Cnidarian, Tripedalia...Full Text Available

1998-11-10

85

Relative potencies for barbiturate binding to the Torpedo acetylcholine receptor.

We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice....Full Text Available

86

Regulation of rat hepatic low density lipoprotein receptors. In vivo stimulation by growth hormone is not mediated by insulin-like growth factor I.

1. The structural requirements of an allosteric barbiturate binding site on acetylcholine receptor-rich membranes isolated from Torpedo electroplaques have been characterized by the ability of fourteen...Full Text Available

1990-11-01

87

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

Growth hormone (GH) has an important role in the regulation of hepatic LDL receptor expression and plasma lipoprotein levels. This investigation was undertaken to evaluate if these effects of GH on...Full Text Available

1996-01-15

88

Receptor mechanisms and dose-response models for the effects of dioxins.

The neonatal Fc receptor FcRn provides IgG molecules with their characteristically long half-lives in vivo by protecting them from intracellular catabolism and then returning them to...Full Text Available

2008-02-19

89

Receptor in group C and G streptococci detects albumin structures present in mammalian species.

There is increasing evidence that receptor-mediated events impact one or more stages responsible for tumor development in experimental animals and humans. Although many chemicals and endogenous hormones...Full Text Available

1993-04-22

90

Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer

The presence of albumin structures with the capacity to bind to a surface receptor in group C and G streptococci was studied in serum samples from 45 mammalian species representing 15 different orders,...Full Text Available

1982-05-01

91

Quantitative Analysis of Endocytosis and Turnover of Epidermal Growth Factor (EGF) and EGF Receptor

Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor...Full Text Available

92

Purification of functional baculovirus particles from silkworm larval hemolymph and their use as nanoparticles for the detection of human prorenin receptor (PRR) binding

Binding of epidermal growth factor (EGF) to the EGF receptor (EGFR) initiates signal transduction, ultimately leading to altered gene expression. Ligand-activated EGFR is also rapidly internalized...Full Text Available

2010-03-01

93

Predictive and prognostic markers for epidermal growth factor receptor inhibitor therapy in non-small cell lung cancer

BackgroundBaculovirus, which has a width of 40 nm and a length of 250-300 nm, can display functional peptides, receptors and antigens on its surface by their fusion with a baculovirus...Full Text Available

94

Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study

Epidermal growth factor receptor (EGFR) related therapies – mainly tyrosine kinase inhibitors (TKIs) such as erlotinib and gefitinib, but also monoclonal antibodies targeting EGFR, for example,...Full Text Available

2009-11-01

95

Novel Analogs and Stereoisomers of the Marine Toxin Neodysiherbaine with Specificity for Kainate Receptors

BackgroundPolymorphisms in Epidermal Growth Factor Receptor (EGFR) gene may influence EGFR production and/or activity, thereby modulating susceptibility to lung...Full Text Available

96

New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders

Antagonists for kainate receptors (KARs), a family of glutamate-gated ion channels, are efficacious in a number of animal models of neuropathologies, including epilepsy, migraine pain, and anxiety....Full Text Available

2008-02-01

97

Neurotensin Receptor 1 Is Expressed in Gastrointestinal Stromal Tumors but Not in Interstitial Cells of Cajal

Ionotropic P2X and metabotropic P2Y purinergic receptors are expressed in the central nervous system and participate in the synaptic process particularly associated with acetylcholine, GABA, and glutamate...Full Text Available

2007-09-01

98

Multiple Functions of the 37/67-kd Laminin Receptor Make It a Suitable Target for Novel Cancer Gene Therapy

Gastrointestinal stromal tumors (GIST) are thought to derive from the interstitial cells of Cajal (ICC) or an ICC precursor. Oncogenic mutations of the KIT or PDGFRA receptor tyrosine kinases are present...Full Text Available

99

Lack of LDL Receptor Enhances Amyloid Deposition and Decreases Glial Response in an Alzheimer's Disease Mouse Model

The 37/67-kd laminin receptor, LAMR, is a multifunctional protein that associates with the 40S ribosomal subunit and also localizes to the cell membrane to interact with the extracellular matrix. LAMR...Full Text Available

2010-01-01

100

Kinetic Complexity of the Global Response to Glucocorticoid Receptor Action

BackgroundApolipoprotein E (ApoE), a cholesterol carrier associated with atherosclerosis, is a major risk factor for Alzheimer's disease (AD). The low-density lipoprotein receptor...Full Text Available

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

101

Isolation and partial characterization of a specific alpha-fetoprotein receptor on human monocytes.

We have characterized the kinetic response of gene targets throughout the murine genome to transcriptional modulation by the glucocorticoid receptor (GR). In contrast to a model in which multiple genes...Full Text Available

2009-04-01

102

Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy

Since a large body of data has suggested a significant role for alpha-fetoprotein (AFP) in the regulation of the immune response at a number of levels, we examined the possibility of a specific receptor...Full Text Available

1992-10-01

103

Induction of Oxidative Stress Responses by Dioxin and other Ligands of the Aryl Hydrocarbon Receptor

The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with...Full Text Available

2008-11-01

104

Identification of LRRc17 as a Negative Regulator of Receptor Activator of NF-?B Ligand (RANKL)-induced Osteoclast Differentiation*S?

TCDD and other polyhalogenated aromatic hydrocarbon ligands of the aryl hydrocarbon receptor (AHR) have been classically considered as non-genotoxic compounds because they fail to be directly mutagenic...Full Text Available

105

Functional Analysis of the Murine Cytomegalovirus Chemokine Receptor Homologue M33: Ablation of Constitutive Signaling Is Associated with an Attenuated Phenotype In Vivo?

Osteoblasts are the primary cells responsible for bone formation. They also support osteoclast formation from bone marrow precursors in response to osteotropic factors by inducing receptor activator...Full Text Available

2009-05-29

106

Expression of Fc receptors is suppressed in alveolar macrophages from patients with sarcoidosis.

The murine cytomegalovirus (MCMV) M33 gene is conserved among all betaherpesviruses and encodes a homologue of seven-transmembrane receptors (7TMR) with the capacity for constitutive signaling. Previous...Full Text Available

2008-02-01

107

Evidence for an association between TSH and IGF-1 receptors

To study the expression of Fc receptors in human alveolar macrophages (AM), the cells were collected from 12 healthy controls and 22 patients with sarcoidosis and the activity involved in binding to...Full Text Available

1988-09-01

108

Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats

TSH receptor (TSHR) plays a central role in regulating thyroid function and is targeted by IgGs in Graves’ disease (GD-IgG). Whether TSHR is involved in the pathogenesis of thyroid associated...Full Text Available

2008-09-15

109

Development of a Selective Modulator of Aryl Hydrocarbon (Ah) Receptor Activity that Exhibits Anti-Inflammatory Properties

Dysregulation of glutamate neurotransmission may play a role in cognitive deficits in schizophrenia. Manipulation of glutamate signaling using drugs acting at metabotropic glutamate receptors...Full Text Available

2010-08-10

110

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. However, the role of the AHR...Full Text Available

2010-05-17

111

Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV.

OBJECTIVEPrevious studies showed that genetic deletion or pharmacological blockade of the receptor for advanced glycation end products (RAGE) prevents the early structural changes...Full Text Available

2010-08-01

112

Characterisation of the Expression of NMDA Receptors in Human Astrocytes

The cellular receptor for murine coronavirus mouse hepatitis virus (MHV)-A59 is a member of the carcinoembryonic antigen (CEA) family of glycoproteins in the immunoglobulin superfamily. We isolated...Full Text Available

1991-12-01

113

Biochemical characterization of the molecular interaction between recombinant basic fibroblast growth factor and a recombinant soluble fibroblast growth factor receptor.

Astrocytes have long been perceived only as structural and supporting cells within the central nervous system (CNS). However, the discovery that these glial cells may potentially express receptors capable...Full Text Available

114

Attenuation of Cocaine's Reinforcing and Discriminative Stimulus Effects via Muscarinic M₁ Acetylcholine Receptor StimulationS?

The extracellular domain of human fibroblast growth factor receptor (XC-FGF-R) was expressed in Escherichia coli. The protein was purified to homogeneity and the interaction with basic fibroblast growth...Full Text Available

1993-09-15

115

Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence

Muscarinic cholinergic receptors modulate dopaminergic function in brain pathways thought to mediate cocaine's abuse-related effects. Here, we sought to confirm and ...Full Text Available

2010-01-01

116

Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors.

Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha...Full Text Available

2011-03-01

117

Antidepressant-Like Effects of ?-Opioid Receptor Antagonists in Wistar Kyoto Rats

Polyclonal antibodies were raised in rabbits by immunization with free peptides corresponding to positions 197-222 of the human beta 1-adrenergic receptor (beta 1 peptide) and the corresponding sequence...Full Text Available

1989-10-01

118

An analysis by low-angle neutron scattering of the structure of the acetylcholine receptor from Torpedo californica in detergent solution.

The Wistar Kyoto (WKY) rat strain is a putative genetic model of comorbid depression and anxiety. Previous research showing increased κ-opioid receptor (KOR)...Full Text Available

2010-02-01

119

Activated PPAR? Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells

The acetylcholine receptor from the electric tissue of Torpedo californica is a large, integral membrane protein containing four different types of polypeptide chains. The structure of the purified...Full Text Available

1979-12-01

120

Acetylcholine receptor kinetics. A description from single-channel currents at snake neuromuscular junctions.

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights...Full Text Available

2008-01-01

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121

A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer

Single-channel currents from acetylcholine receptor channels of garter snake neuromuscular junctions were recorded using the patch-clamp technique. Low concentrations of acetylcholine or carbamylcholine...Full Text Available

1982-09-01

122

A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulability in Off-Pump Coronary Surgery

IntroductionVarious multigene predictors of breast cancer clinical outcome have been commercialized, but proved to be prognostic only for hormone receptor (HR) subsets overexpressing...Full Text Available

2010-01-01

123

A Point Mutation in a Domain of Gamma Interferon Receptor 1 Provokes Severe Immunodeficiency

BACKGROUNDOff-pump coronary artery bypass (OPCAB) surgery is associated with a hypercoagulable state in which the platelet thrombin receptor, protease-activated receptor-1...Full Text Available

2009-11-01

124

crystal-liquid phase transition of oriented polymeric systems< semiannual status report

Gamma interferon (IFN-γ) and the cellular responses induced by it are essential for controlling mycobacterial infections. Most patients bearing an IFN-γ receptor ligand-binding chain...Full Text Available

2001-01-01

125

The beaver's reconquest of Eurasia: status, population development, and management of a conservation success

No Abstract Available

1965-01-01

126

Norwegian Open Research Archives (NORA)

Full Text Available

127

Study on Present Status of Poultry Farming and Improvement of Technical Management for Poultry Production

Status of the analysis of the (vector)pp {yields} pp{gamma} reaction channel

Full Text Available

1981-10-01

128

Spent fuel sabotage aerosol ratio test program:status update, November 2004.

No abstract prepared.

2002-03-01

129

Spent fuel sabotage aerosol ratio test program : progress & status, May 2004.

No abstract prepared.

2004-11-01

130

Spent fuel sabotage aerosol ratio program : status, May 2005.

No abstract prepared.

2004-05-01

131

Environmental and resource economics in South Africa: status quo and lessons for developing countries

No abstract prepared.

2005-05-01

132

CSIR Research Space (South Africa)

Full Text Available

133

Effects of season and body condition score on lipid metabolism and oxidative status of periparturient dairy cows

Drug Abuse Status and Its Determinants of Male High School Students in Taegu

No abstract prepared.

2005-07-01

134

Deforestation: Environmental impact and research needs

Full Text Available

1996-09-01

135

CURRENT STATUS AND IMPORTANT ISSUES ON SEISMIC HAZARD EVALUATION METHODOLOGY IN JAPAN

The status of research on environmental problems that are produced by the phenomena of global deforestation is examined.

1983-01-01

136

A medication-estimated health status measure for predicting primary care visits: the Long-Term Therapeutic Groups Index.

Full Text Available

2009-12-01

137

Structure of Artemin Complexed With Its Receptor GFRalpha3: Convergent Recognition of Gilial Cell Line-Derived Neurotropic Factors

PMID:19923207

2009-11-18

138

Photolabelling reveals differences between cholera toxin and ricin toxin insertion mechanisms

No abstract prepared.

2007-08-08

139

Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity

... carbon 14 cholera gels labelling membranes molecules proteins receptors

1982-07-28

140

P2X1 receptor mobility and trafficking; regulation by receptor insertion and activation

BackgroundTo evaluate whether P2X receptors are involved in responses to noxious pulp stimulation, the P2X₃and P2X_2/3receptor agonist α,β-methyleneATP...Full Text Available

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141

Nuclear receptor co-repressor SMRT regulates mitochondrial oxidative metabolism and mediates aging related metabolic deterioration

P2X1 receptors for ATP contribute to signalling in a variety of cell types and following stimulation undergo rapid desensitisation (within 1 s), and require ∼5 min to recover. In HEK293 cells...Full Text Available

2010-06-01

142

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor ?-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of ?-Catenin Signaling*

SummaryThe transcriptional co-repressor SMRT utilizes two major receptor interacting domains (RID1 and RID2) to mediate nuclear receptor (NR) signaling through epigenetic modification....Full Text Available

2010-12-01

143

Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation

The capacity of bones to adjust their mass and architecture to withstand the loads of everyday activity derives from the ability of their resident cells to respond appropriately to the strains engendered....Full Text Available

2010-03-19

144

Extraribosomal functions associated with the C terminus of the 37/67?kDa laminin receptor are required for maintaining cell viability

BackgroundEstrogen receptors alpha (ERα) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype...Full Text Available

145

Cloning and characterization of a 77-kDa oestrogen receptor isolated from a human breast cancer cell line.

The 37/67 kDa laminin receptor (LAMR) is a multifunctional protein, acting as an extracellular receptor, localizing to the nucleus, and playing roles in rRNA processing and ribosome assembly....Full Text Available

2010-05-01

146

Characterization of an oligopeptide chemoattractant receptor on human blood monocytes using a new radioligand

We have cloned and characterized a 77-kDa oestrogen receptor (ER) from an oestrogen-independent subclone of the MCF-7 human breast cancer cell line. This receptor contains an in-frame, tandem duplication...Full Text Available

1997-01-01

147

Status of FFTF startup program and future FFTF utilization

The study of chemoattractant receptors on human monocytes had been limited by the lack of a radioligand suitable for use with the small numbers of cells routinely available from human donors. A new synthetic oligopeptide radioligand f(/sup 35/S)Met-leu-phe, with a higher specific radioactivity than was available with the tritiated compound, was used to characterize a chemoattractant receptor on freshly isolated human blood monocytes. These cells bind f(/sup 35/)met-leu-phe with a dissociation constant (KD) of 30.2 +/- 5.6 nM and contain 84,000 +/- 11,300 receptors per cell. f(/sup 35/)met-leu-phe does not bind specifically to blood lymphocytes. The specificity of the oligopeptide receptor on monocytes is indistinguishable from the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes. Using f(/sup 35/)met-leu-phe, it will now be feasible to study the ...

1984-03-01

148

Phases of a two dimensional large N gauge theory on a torus

A brief FFTF project description is provided which includes general plant siting information, general layout, plant design parameters, description of principal systems and components, and description of support facilities. The current status of the FFTF project is provided, including status of plant construction, overall status of the plant checkout and test program, status of operating authorization and plant operating procedures and personnel, and status of reactor core components and experiments. Specific information on the acceptance test program and early program results is discussed. The role of FFTF in the future breeder program is described, including its objectives for verification of plant system and components designs and operability and use as an irradiation test facility.

1978-10-25

149

D2-40, Podoplanin, and CD31 as a Prognostic Predictor in Invasive Ductal Carcinomas of the Breast

We consider two-dimensional large N gauge theory with D adjoint scalars on a torus, which is obtained from a D+2 dimensional pure Yang-Mills theory on T^{D+2} with D small radii. The two dimensional model has various phases characterized by the holonomy of the gauge field around non-contractible cycles of the 2-torus. We determine the phase boundaries and derive the order of the phase transitions using a method developed in an earlier work (hep-th/0910.4526), which is nonperturbative in the 'tHooft coupling and uses a 1/D expansion. We embed our phase diagram in the more extensive phase structure of the D+2 dimensional Yang-Mills theory and match with the picture of a cascade of phase transitions found earlier in lattice calculations (hep-lat/0710.0098). We also propose a dual gravity system based on a Scherk-Schwarz compactification of a ...

2011-01-01

150

Insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes

PurposeDistant metastasis and recurrence are major prognostic factors associated with breast cancer. Both lymphovascular invasion (LVI) and blood vessel invasion (BVI) are important...Full Text Available

2011-06-01

151

Dissociation of insulin receptor phosphorylation and stimulation of glucose transport in BC3H-1 myocytes

Incorporation of /sup 32/P from (gamma-32P)ATP into tyrosine residues of the insulin-like growth factor (IGF)-II receptor was observed in a Triton X-100-insoluble fraction of rat adipocyte plasma membranes. IGF-II receptor phosphorylation proceeded to a stoichiometry of approximately 0.5 mol of phosphate/IGF-II binding site after 10 min of incubation at 4 degrees C. A Km for ATP of 6 microM was calculated for this phosphorylation reaction. Addition of IGF-II caused an approximately 2-fold increase in tyrosine phosphorylation of the IGF-II receptor in this preparation. In contrast, phosphorylation of angiotensin II by the Triton X-100 washed membranes was not stimulated by IGF-II. Incubation of purified receptor immobilized on IGF-II agarose or of receptor-enriched low density microsomal membranes with (gamma-32P)ATP did not result in appreciable incorporation of (/sup 32/P)phosphate ...

1986-06-15

152

YM on the dielectric brane: a D0-brane tale

The authors have investigated insulin receptor phosphorylation in differentiated cultured BC3H-1 myocytes. As for other insulin-responsive cell systems in partially purified wheat germ agglutinin receptor preparations, insulin stimulates the phosphorylation of its own receptor (95K ..beta..-subunits) in a dose dependent manner (0-400 nM), as identified by immunoprecipitation with antiinsulin receptor antibodies and SDS-PAGE. In the same preparations they show that 12-0-tetradecanyl phorbol acetate (TPA), which in many respect ..beta..-subunits in the same dose dependent manner (0-5 ..mu..M). In addition, antiinsulin receptor antibodies (B-10) also induced phosphorylation of mimics insulin action, also induced phosphorylation of the insulin receptor and HPLC tryptic maps of the /sup 32/P-labeled ..beta..-subunit were identical to those for insulin-induced ...

1986-05-01

153

Manifestation of isotope effects in absorption spectra of "1"4"4Sm"3"+ and "1"5"4Sm"3"+ in solutions

In this letter we present a derivation, from the D0-brane picture, of the background monopole field and in general of the full dynamics of the Yang-Mills theory on the dielectric D2-brane of Myers. To do this we study the large N limit of the fuzzy sphere relevant to the dielectric solution. In contrast to the usual interpretation where the commutative D2-brane picture arises directly from the large N limit of the D0-brane picture, we find that a residual non-commutativity must be preserved in order to make the connection by means of the Seiberg-Witten map.

2003-08-25

154

The Influence of Weight and Height Status on Psychological Problems of Elementary Schoolchildren through Child Behavior Checklist Analysis

Photoluminescence spectra for solutions containing Sm"3"+ isotope ions in heavy and normal water were studied in the wave length #lambda# = 500-700 nm and for absorption spectra and photoluminescence excitation spectra within the range of #lambda# = 260-600 nm. Differences in molar extinction coefficients for "1"4"4Sm"3"+ and "1"5"4Sm"3"+ were established both in the solutions with D_2O and by transition from the solutions with D_2O to the solutions with H_2O. New possible causes of the identified effects are discussed

1998-01-01

155

Status of electron accelerators for linear colliders

PurposeThis study aimed to evaluate weight and height status and their relationship with psychological problems among elementary schoolchildren.Materials and...Full Text Available

2009-06-30

156

Socioeconomic Status and Depressive Syndrome: The Role of Inter- and Intra-generational Mobility, Government Assistance, and Work Environment*

The paper outlines the basic problems concerning creation of electron-positron linear colliders, as well as their present-day status. More details on the question can be found in the proceedings of recent workshops on linear colliders contained in the References. ((orig.)).

1995-02-01

157

SIRGAS Project: present status; Projeto SIRGAS: estagio atual

This paper assesses the hypothesis that depressive syndrome is associated with socioeconomic status, using longitudinal data from the Baltimore Epidemiologic Catchment Area Followup. Socioeconomic...Full Text Available

2001-09-01

158

Nutritional status of iodine in pregnant women in Catalonia (Spain): study on hygiene-dietetic habits and iodine in urine

The status of the South American Geocentric reference System (SIRGAS) Project is presented, including the project goals, objectives and tasks already carried out by the Working Groups. (author). 2 refs., 1 fig., 1 tab

1995-12-31

159

Hanford Site environmental report for calendar year 1989

BackgroundIt is a priority to achieve an adequate nutritional status of iodine during pregnancy since iodine deficiency in this population may have repercussions on the mother during...Full Text Available

160

Council tax valuation band predicts breast feeding and socio-economic status in the ALSPAC study population

This report is a summary of the environmental status of the Hanford Site in 1989. It includes descriptions of the Site and its mission, the status of compliance with environmental regulations, planning and activities to accomplish compliance, environmental protection and restoration activities, and environmental monitoring. 97 refs., 67 figs., 14 tabs.

1990-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

The Inhibition of Epileptogenesis During Status Epilepticus by Ginsenosides of Korean Red Ginseng and Ginseng Cell Culture (Dan25)

BackgroundBreast-feeding rates in the UK are known to vary by maternal socio-economic status but the latter function is imperfectly defined. We test if CTVB (Council Tax Valuation...Full Text Available

162

Spinal cord stimulation in treatment of chronic benign pain: challenges in treatment planning and present status, a 22-year experience.

Full Text Available

2007-09-01

163

Socioeconomic Data and Applications Center (SEDAC) Treaty Status ...

PMID:16528188

2006-03-01

164

October 2003 Status of Forces Survey of DoD Civilians ...

CONTINENT > EUROPE > EASTERN EUROPE > CZECH REPUBLIC .... CIESIN > Industry and Energy > Energy Production > Nuclear Energy ...

165

Fishes of Georgia: Georgia Freshwater Fish Distribution, Classification, and Information

... h. Sick leave ..... 162 ... appraisals and approval of leave. ... Retirement System, FERS are employees ...

2004-03-01

166

Dual Use Technology: Status, Issues, and Change

Georgia Fish: Freshwater fish distributions,classification, conservation status, and distribution comments for Georgia....

167

The development of sigma-receptor specific radiopharmaceuticals for spect imaging of human tumors

... two sectors. ' One company used as example of this process is the Lord Corporation, which produces products that reduce ...

1993-04-01

168

Suppression of receptors for prolactin and estrogen in rat liver due to treatment with the growth hormone analogue produced by the tapeworm Spirometra mansonoides.

The authors have been involved for the last few years in developing high affinity sigma-receptor-specific radiopharmaceuticals for use in nuclear medicine. They recently demonstrated that sigma-1 receptors are expressed in human melanoma cells and that sigma receptors could be used as external markers for non-invasive imaging. In order to determine the presence of sigma receptors in other human tumors they have screened numerous non-small cell lung carcinoma, melanoma and breast cancer cell lines. All of these cell lines expressed high sigma receptor densities using commercially available ["3H]-(+)-pentazocine or ["3H]DTG tritiated sigma ligands. Therefore, a sigma ligand with high affinity in both sigma-1 and sigma-2 subtype pharmacological assays could be potentially useful for imaging a variety of primary and metastatic sites of various origins. The authors describe recent ...

1994-08-21

169

Characterization of the xanthine-binding site on R/sub a/ and R/sub i/ subtypes of the adenosine receptor

Somatogenic hormones play an important role in regulation of receptors for prolactin (PRL) and estrogen. Plerocercoids of the tapeworm, S. mansonoides produce a factor which mimics some, but not all of the actions reported for GH. Intact female rats were subjected to a constant infusion of plerocercoid growth factor (PGF) via a subcutaneous infection for two weeks to determine if PGF influences receptors for PRL, GH or estradiol. The rate of weight gain in the PGF-treated rats was accelerated in spite of a marked reduction in serum GH. Partially-purified PGF specifically displaced [125I]hGH from rat liver receptors but microsomes prepared from rats treated with PGF specifically bound significantly less [125I]hGH than microsomes from control rats. The reduction in [125I]hGH binding was not due to occupancy or to a change in affinity but to a suppression in receptor concentration. Scatchard analysis of ...

1986-01-01

170

Commercial Demonstration of the Manufactured Aggregate Processing Technology Utilizing Spray Dryer Ash

Methylxanthines and their derivatives are antagonists at cell surface adenosine receptors. They report here a systematic study of xanthine structure-activity relationships which compares potency at two adenosine receptor subtypes, R/sub a/ and R/sub i/. Adenylate cyclase stimulation (R/sub a/ in platelet membranes) and inhibition (R/sub i/ in adipocyte membranes) were used as models of receptor activation. K/sub i/ values were obtained by Schild analysis. The orders of potency of the xanthines to attenuate the effects of adenosine analogues were similar to those previously reported. Earlier work utilizing radioligand binding (R/sub i/ and (/sup 3/H) cAMP formation (R/sub a/) claimed that IIX and PACPX are at least 10 and 400 fold, respectively, more potent at R/sub i/ than at R/sub a/. However, in their assays which utilize modulation of receptor-coupled adenylate cyclase, the xanthines show little ...

1986-05-01

171

Visualization of Tumor Angiogenesis Using MR Imaging Contrast Agent Gd-DTPA-anti-VEGF Receptor 2 Antibody Conjugate in a Mouse Tumor Model.

This quarterly report covers the period from January 1, 2005 through March 31, 2005. It covers: technical development, permitting status, engineering status, construction status, operations summary and marketing support activities for this period. Plant startup is still continuing. Testing of admixtures to enhance extrusion and SDA wetting is continuing. Efforts are underway to improve plant availability.

2005-05-01

172

The skeletal muscle ryanodine receptor identified as a molecular target of[3H] azidodantrolene by photoaffinity labeling

Full Text Available

2010-07-01

173

The interaction of trazodone with rat brain muscarinic cholinoceptors.

... 16, 2001 0006-2979 BIORAK v. 40(2) APPLIED LIFE SCIENCES azido

2001-04-01

174

The hepcidin-binding site on ferroportin is evolutionarily conserved

The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]-quinuclidinyl benzilate...Full Text Available

1980-01-01

175

The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors

SummaryMammalian iron homeostasis is regulated by the interaction of the liver-produced peptide hepcidin and its receptor, the iron transporter ferroportin. Hepcidin binds to...Full Text Available

2008-08-01

176

THE STIMULATING EFFECT OF GLYCOLS AND THEIR POLYMERS ON THE TARSAL RECEPTORS OF BLOWFLIES

SUMMARYTestosterone and estrogen are essential for male behaviors in vertebrates. How these two signaling pathways interact to control masculinization of the brain and behavior...Full Text Available

2010-04-29

177

Site-Specific Methylation of the Promoter Alters Deoxyribonucleic Acid-Protein Interactions and Prevents ...

The rejection thresholds of Phormia regina Meigen for twenty-four glycols have been determined. A definite relationship between the concentration of the test material and the distribution...Full Text Available

1948-11-20

178

Role of the 5HT3 Receptor in Alcohol Drinking and ...

... and R. L. Momparler. DNA methylation of retinoic acid receptor beta in breast cancer and possible therapeutic role of ... ...

179

Purinergic receptors in the splanchnic circulation

... Proc Natl Acad Sci USA 97:11032-7 27. Duman RS 2002 Genetics of childhood disorders: XXXIX. Stem cell research, part 3: ...

2005-09-01

180

Possible Implications of Placental Expressions for Heat Shock Protein 70 and Lectin-like Oxidized Low Density Lipoprotein Receptor-1 on Postnatal Blood Pressure in Their Newborns

There is considerable evidence that purines are vasoactive molecules involved in the regulation of blood flow. Adenosine is a well known vasodilator that also acts as a modulator of the response to...Full Text Available

2008-09-01

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181

Molecular Aspects of Thyroid Hormone Actions

Full Text Available

2007-09-01

182

Missense mutations in the growth hormone receptor dimerization region in Laron syndrome

Cellular actions of thyroid hormone may be initiated within the cell nucleus, at the plasma membrane, in cytoplasm, and at the mitochondrion. Thyroid hormone nuclear receptors (TRs) mediate the biological...Full Text Available

2010-04-01

183

Kinetic manifestation of cooperative interaction between quinuclidinyl benzilate and rat brain muscarine cholinoreceptors

Laron syndrome (LS) is an autosomal recessively inherited condition characterized by insensitivity to endogenous and exogenous GH. Affected individuals have severe episodes and other characteristic features. GH receptor gene mutations are present in all affected individuals in whom molecular studies have been reported. The GH receptor is a plasma membrane-spanning protein in which the extracellular domain binds circulating GH and the intracellular domain interacts with the JAK-2 kinase and possibly other intracellular signaling molecules. GH receptor dimerization occurs on GH binding and is thought to be required for normal signal transduction. We have studied the GH receptor genes of four unrelated individuals affected with LS from the United States, Italy, Saudi Arabia, and India. We have identified four different missense mutations that alter consecutive amino acids 152 to 155 in or near the ...

1994-09-01

184

Influence of KDEL on the Fate of Trimeric or Assembly-Defective Phaseolin

A study was made of the kinetics of L-(/sup 3/H)quinuclidinyl benzilate binding with membrane-bound muscarine cholinoreceptors from the rat brain. Determination was made of the rate constants of this process, and constants as a function of ligand concentration was investigated, indicating that there is a complex mechanism of interaction of antagonists with muscarine receptor. With up to 3.5 nM concentrations of L-(/sup 3/H)quinuclidinyl benzilate, the binding reaction occurs in two stages: rapid equilibrated binding is followed by a slow process of conformational isomerization of the receptor-ligand complex. At higher ligand concentrations, there is additional drastic increase in constant of rate of ligand binding a new plateau is reached. Such dependence of rate constant on ligand concentration is indicative of the cooperative nature of interaction between antagonists and muscarine receptors. This is possible if there are ...

1985-01-01

185

Hypothyroidism Enhances Tumor Invasiveness and Metastasis Development

The tetrapeptide KDEL is commonly found at the C terminus of soluble proteins of the endoplasmic reticulum (ER), and it contributes to their localization by interacting with a receptor that recycles...Full Text Available

2001-05-01

186

Effect of propylbenzilylcholine mustard on contraction and radioligand binding parameters of muscarinic receptors in guinea pig ileum

BackgroundWhereas there is increasing evidence that loss of expression and/or function of the thyroid hormone receptors (TRs) could result in a selective advantage for tumor development,...Full Text Available

187

Characterization of lymphocyte receptors for glycosaminoglycans.

The receptor occupancy-biological effect relationship for muscarinic receptors in guinea pig ileal smooth muscle has been studied by comparison of radioligand binding and contractile response. Muscarinic receptors in homogenates of ileal smooth muscle were labeled with (/sub 3/H)-1-Quinuclidinyl benzilate. Treatment with propylbenzilylcholine mustard (PrBCM), to inactivate irreversibly muscarinic receptors, caused a large dose dependent rightward shift of the dose-response curve to three agonistic furtrethonium derivatives with a concomitant decrease in maximal response. Using those data, the fraction of receptors remaining unoccupied (q-values) and true affinity constants (-log K/sub A/-values) were calculated. Exposure to 20 or 60 nM PrBCM for 15 minutes resulted in a 39% and a 61% reduction in specific (/sup 3/H)-1-Quinuclidinyl benzilate binding sites respectively to be compared ...

1987-10-26

188

Cardioprotection conferred by exercise training is blunted by blockade of the opioid system

This paper describes attempts to isolate and characterize glycosaminoglycan (GAG)-binding molecules on the surface of lymphocytes and lymphoma cell lines and relate their expression to splenic and lymph...Full Text Available

1991-02-01

189

Carbohydrate-specified endocytosis: localization of ligand in the lysosomal compartment.

OBJECTIVES:To investigate the effect of opioid receptor blockade on the myocardial protection conferred by chronic exercise and to compare exercise training with different strategies...Full Text Available

2011-01-01

190

Acetylcholine Receptor Binding Characteristics of Snake and ...

Carbohydrate-directed endocytosis is mediated by a receptor, the hepatic binding protein; it is responsible for the clearance of galactose-terminated glycoproteins from the circulation. This process...Full Text Available

1981-11-01

191

AN ELECTROPHYSIOLOGICAL ANALYSIS OF THE ACTION OF CARBOHYDRATES ON THE SUGAR RECEPTOR OF THE BLOWFLY^*

... Naja oxiana neurotoxin 1, Bungarus multicinctus or-bungarotoxin) and short-chain group (Naja naja atra cobrotoxin, Naja oxiana neurotoxin 11. ...

2011-05-13

192

Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by deep etching electron microscopy

Measurements of the taste thresholds of blowflies for a wide variety of carbohydrates, presented individually and in combination, showed that the stimulating effects of the compounds are not always...Full Text Available

1969-01-01

193

The Expression Level of CB₁ and CB₂ Receptors Determines Their Efficacy at Inducing Apoptosis in Astrocytomas

SummaryThe receptors for the second messenger InsP₃ comprise a family of closely related ion channels that release Ca²⁺ from intracellular stores, most prominently...Full Text Available

2010-09-01

194

The C'-terminal interaction domain of the thyroid hormone receptor confers the ability of the DNA site to dictate positive or negative transcriptional activity

BackgroundCannabinoids represent unique compounds for treating tumors, including astrocytomas. Whether CB₁ and CB₂ receptors mediate this therapeutic effect...Full Text Available

195

Selective stimulation of catecholamine release from bovine adrenal chromaffin cells by an ionotropic purinergic receptor sensitive to 2-methylthio ATP

To investigate mechanisms responsible for positive and negative transcriptional control, the authors have utilized two types of promoters that are diffferentially regulated by thyroid hormone (T{sub 3}) receptors. Promoters containing the palindromic T{sub 3} response element TCAGGTCA TGACCTGA are positively regulated by the T{sub 3} receptor after the administration of T{sub 3}, whereas otherwise identical promoters containing the estrogen response element TCAGGTCA CTG TGACCTGA can be regulated negatively; converse effects are observed with the estrogen receptor. They describe evidence that the transcriptional inhibitory effects of the T{sub 3} or estrogen receptors on the estrogen or T{sub 3} response elements, respectively, are imposed by amino acid sequences in the C'-terminal region that colocalize with dimerization and hormone-binding domains and that these sequences can transfer ...

1990-10-01

196

Ryanodine produces a low frequency stimulation-induced NMDA receptor-independent long-term potentiation in the rat dentate gyrus in vitro.

Background2-Methylthioadenosine 5'-triphosphate (2-MeSATP), formerly regarded as a specific P2Y (metabotropic) purinergic receptor agonist, stimulates Ca²⁺influx and...Full Text Available

197

Roles of the TNF receptor-associated factor (TRAF)2/3 binding site in differential B cell signaling by CD40 and its viral oncogenic mimic, latent membrane protein 1 (LMP1)

1. The induction of long-term potentiation (LTP) was investigated in the rat dentate gyrus in the presence of ryanodine, an agent which is known to selectively bind to the ryanodine receptor (RyR) Ca2+...Full Text Available

1996-09-15

198

Role of intrathecal tachykinins for micturition in unanaesthetized rats with and without bladder outlet obstruction.

The Epstein-Barr virus protein, LMP1, is a functional mimic of the cellular receptor CD40, but signals to B lymphocytes in an amplified and sustained manner compared to CD40. LMP1 contributes...Full Text Available

2009-09-01

199

Reinforcing Effects of ?-Receptor Agonists in Rats Trained to Self-Administer Cocaine

1. The effects on micturition of RP 67,580, a selective NK1 receptor antagonist, and SR 48,968, a highly, potent antagonist at NK2 receptor sites, given intrathecally (i.t.) or intra-arterially (i.a.)...Full Text Available

1994-09-01

200

Reduced expression of a human V beta 6.1 T-cell receptor allele.

σ-Receptor (σR) antagonists have been reported to block certain effects of psychostimulant drugs. The present study examined the effects of σR ligands in rats trained to self-administer...Full Text Available

2010-02-01

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201

Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

We have previously described an allelic polymorphism in the V beta 6.1 T-cell receptor gene. The V beta 6.1B allele is associated with disease in a subgroup of patients with juvenile rheumatoid arthritis....Full Text Available

1993-05-15

202

Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells

Here, we provide the first study of prolactin (PRL) and prolactin receptor (PRLR) expression during the nonseasonal murine hair cycle, which is, in contrast to sheep, comparable with the human scalp...Full Text Available

2003-05-01

203

Pharmacokinetics and pharmacodynamics of terbogrel, a combined thromboxane A₂ receptor and synthase inhibitor, in healthy subjects

Airway ciliated cells express an ATP-gated P2X receptor channel of unknown subunit composition (P2X_cilia) which is modulated by Na⁺ and by long exposures to ATP. P2X_cilia...Full Text Available

2006-03-15

204

Neuroactive steroids have multiple actions to potentiate GABA_A receptors

AimsTo characterize the pharmacokinetics of terbogrel, a new combined thromboxane A₂ (TxA₂) receptor and synthase inhibitor, in healthy human subjects after...Full Text Available

2004-07-01

205

Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction

The effects of neuroactive steroids on the function of GABA_A receptors were studied using cell-attached records of single channel activity recorded from HEK293 cells transfected with α1...Full Text Available

2004-07-01

206

Molecular recognition of nitrated fatty acids by PPAR[gamma

Although peroxisome proliferator-activated receptor alpha (PPARα) is closely associated with myocardial fatty acid metabolism, the pathophysiological role of PPARα in myocardial infarction...Full Text Available

2003-01-01

207

Low concentrations of primaquine inhibit degradation but not receptor-mediated endocytosis of asialoorosomucoid by HepG2 cells

Peroxisome proliferator activated receptor-{gamma} (PPAR{gamma}) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR{gamma} ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR{gamma}. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR{gamma} discrimination of various naturally occurring fatty acid derivatives.

2010-03-08

208

Low concentrations of primaquine inhibit degradation but not receptor-mediated endocytosis of asialoorosomucoid by HepG2 cells

Asialoorosomucoid (ASOR) is internalized and degraded by HepG2 cells after binding to the asialoglycoprotein (ASGP) receptor, internalization through the coated pit/coated vesicle pathway, and trafficking to lysosomes. Primaquine, an 8-aminoquinoline antimalarial compound, inhibits ASOR degradation at concentrations greater than 0.2 mM by neutralizing intracellular acid compartments. This leads to alterations in surface receptor number, receptor-ligand dissociation, and receptor recycling. We have investigated the effects of primaquine on 125I-ASOR uptake and degradation as a function of primaquine concentration and duration of exposure. Concentrations below those required for neutralization of acidic compartments block 125I-ASOR degradation in HepG2 cells and lead to intracellular ligand accumulation. This effect is maximal at 80 microM primaquine. The intracellular 125I-ASOR is undegraded, dissociated ...

1991-02-01

209

Kinetic analysis of transport and opioid receptor binding of ( sup 3 H)(-)-cyclofoxy in rat brain in vivo: Implications for human studies

Asialoorosomucoid (ASOR) is internalized and degraded by HepG2 cells after binding to the asialoglycoprotein (ASGP) receptor, internalization through the coated pit/coated vesicle pathway, and trafficking to lysosomes. Primaquine, an 8-aminoquinoline antimalarial compound, inhibits ASOR degradation at concentrations greater than 0.2 mM by neutralizing intracellular acid compartments. This leads to alterations in surface receptor number, receptor-ligand dissociation, and receptor recycling. We have investigated the effects of primaquine on 125I-ASOR uptake and degradation as a function of primaquine concentration and duration of exposure. Concentrations below those required for neutralization of acidic compartments block 125I-ASOR degradation in HepG2 cells and lead to intracellular ligand accumulation. This effect is maximal at 80 microM primaquine. The intracellular 125I-ASOR is undegraded, dissociated ...

210

Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and ?₂-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies

(3H)Cyclofoxy (CF: 17-cyclopropylmethyl-3,14-dihydroxy-4,5-alpha-epoxy-6-beta-fluoromorp hinan) is an opioid antagonist with affinity to both mu and kappa subtypes that was synthesized for quantitative evaluation of opioid receptor binding in vivo. Two sets of experiments in rats were analyzed. The first involved determining the metabolite-corrected blood concentration and tissue distribution of CF in brain 1 to 60 min after i.v. bolus injection. The second involved measuring brain washout for 15 to 120 s following intracarotid artery injection of CF. A physiologically based model and a classical compartmental pharmacokinetic model were compared. The models included different assumptions for transport across the blood-brain barrier (BBB); estimates of nonspecific tissue binding and specific binding to a single opiate receptor site were found to be essentially the same with both models. The nonspecific binding equilibrium constant varied ...

1991-03-01

211

Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E₂/EP2 receptor pathway

The immunolocalization of the low density lipoprotein receptor-related protein 1 (LRP1) and its ligand alpha 2-Macroglobulin (α₂M) was examined in tissues from human donor...Full Text Available

2010-08-01

212

Enhanced ?₂-adrenergic receptor (?₂AR) signaling by adeno-associated viral (AAV)-mediated gene transfer

Growth differentiation factor-9 (GDF-9), an oocyte-secreted member of the transforming growth factor β superfamily, progesterone receptor, cyclooxygenase 2 (Cox2; Ptgs2), and the EP2 prostaglandin...Full Text Available

2000-08-29

213

Discordant expression and variable numbers of neighboring GGA- and GAA-rich triplet repeats in the 3' untranslated regions of two groups of messenger RNAs encoded by the rat polymeric immunoglobulin receptor gene.

Backgroundβ₂-Adrenergic receptors (β₂AR) play important regulatory roles in a variety of cells and organ systems and are important therapeutic...Full Text Available

214

Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method.

An unusual S1-nuclease sensitive microsatellite (STMS) has been found in the single copy, rat polymeric immunoglobulin receptor gene (PIGR) terminal exon. In Fisher rats, elements within or beyond the...Full Text Available

1995-04-11

215

Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis

Using an anti-receptor mAb that blocks the attachment of echovirus 7 and related viruses (echoviruses 13, 21, 29 and 33), we have isolated a complementary DNA clone that encodes the human decay-accelerating...Full Text Available

1994-11-01

216

CD5 Is Dissociated from the B-Cell Receptor in B Cells from Bovine Leukemia Virus-Infected, Persistently Lymphocytotic Cattle: Consequences to B-Cell Receptor-Mediated Apoptosis

The aim of this study was to investigate cumulus expansion, nuclear maturation and expression of connexin 43, cyclooxygenase-2 and FSH receptor transcripts in equine cumuli oophori during in vivo and...Full Text Available

217

Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network

Bovine leukemia virus (BLV), a retrovirus related to human T-cell leukemia virus types 1 and 2, can induce persistent nonneoplastic expansion of the CD5⁺ B-cell population, termed...Full Text Available

2001-02-01

218

Autocrine regulation of T-cell activation by ATP release and P2X₇ receptors

The substantia nigra pars reticulata (SNR) controls seizures in a sex-specific manner. At postnatal day 15 (P15), SNR infusion of GABA_A receptor agonist muscimol have proconvulsant...Full Text Available

2008-03-01

219

Assessment of Glucagon-Like Peptide-1 Analogue and Renin Inhibitor on the Binding and Regulation of GLP-1 Receptor in Type 1 Diabetic Rat Hearts

T-cell activation requires the influx of extracellular calcium, although mechanistic details regarding such activation are not fully defined. Here, we show that P2X₇ receptors play a key...Full Text Available

2009-06-01

220

An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice

This study focuses on the effects of long-term renin-angiotensin system suppression and/or incretin mimetic therapies on the regulation and binding affinity of GLP-1 to its receptor in the coronary...Full Text Available

2011-01-01

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221

Adenosine A₁ receptors (A₁Rs) play a critical role in osteoclast formation and function

It has been postulated that fetal vascular abnormalities in aryl hydrocarbon receptor null (ahr^−/−) mice may alter cardiovascular homeostasis in adulthood....Full Text Available

2010-07-15

222

Acute Ca²⁺-Dependent Desensitization of 5-Ht_1A Receptors is Mediated by Activation of Pka in Rat Serotonergic Neurons

Adenosine regulates a wide variety of physiological processes via interaction with one or more G-protein-coupled receptors (A₁R, A_2AR, A_2BR, and A₃R)....Full Text Available

2010-07-01

223

?₁-Fetoprotein Transcription Factor (FTF)/Liver Receptor Homolog-1 (LRH-1) Is an Essential Lipogenic Regulator

This report investigates acute changes in the sensitivity of 5-HT_1A receptors in dorsal raphe (dr) neurons in response to elevated serotonin. DR neurons were isolated from adult rats...Full Text Available

2010-08-11

224

5'-Azido-[3,6-3H2]-1-napthylphthalamic acid, a photoactivatable probe for naphthylphthalamic acid receptor proteins from higher plants: identification of a 23-kDa protein from maize coleoptile plasma membranes.

α₁-Fetoprotein transcription factor (FTF), also known as liver receptor homolog 1 (LRH-1) is highly expressed in liver and intestine, where it is implicated in the regulation...Full Text Available

2010-04-01

225

(-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase*

1-Naphthylphthalamic acid (NPA) is a specific inhibitor of polar auxin transport that blocks carrier-mediated auxin efflux from plant cells. To allow identification of the NPA receptor thought to be...Full Text Available

1992-01-15

226

["3H]QNB binding and contraction of rabbit colonic smooth muscle cells

The ζ chain-associated 70-kDa protein (ZAP-70) of tyrosine kinase plays a critical role in T cell receptor-mediated signal transduction and the immune response. A high level of ZAP-70 expression...Full Text Available

2008-10-17

227

Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells

The authors used radioligand binding and studies of cell contraction to characterize muscarinic receptors on dispersed smooth muscle cells from rabbit proximal and distal colon. Cells obtained after serial incubations in collagenase were used to measure binding of tritiated quinuclidinyl benzilate (["3H]QNB). At 37 degree C, specific ["3H]QNB binding was saturable and linearly related to cell number. Nonlinear regression analysis was used to determine the affinity of ["3H]QNB for its receptor. The IC_5_0 for the muscarinic agonists bethanechol and oxotremorine were 80 and 0.57 #mu#M, respectively. Hill coefficients were 0.67 for both, suggesting more complex interaction involving receptors of different affinities. In studies of cell contraction, bethanechol stimulated a dose-dependent decrease in cell length with half the maximal contraction occurring at 100 pM. These results suggest that (1) contraction is mediated by ...

1987-01-01

228

DEFF Research Database (Denmark)

The temporal development of the effect of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) on the ultrastructure composition and GABA receptor expression in cerebellar granule cells was investigated by quantitative electron microscopy (morphometric analysis) and GABA binding assays. It was found that the cytoplasmic density of smooth endoplasmic reticulum was decreased, while the cytoplasmic density of rough endoplasmic reticulum, Golgi apparatus, vesicles and coated vesicles was greatly enhanced after exposure of the cells to THIP (150 microM) for only 1 hr. In cerebellar granule cells exposed to THIP (150 microM) for 3 hr low affinity GABA receptors were induced. These findings show that the effect of THIP on the ultrastructure composition and GABA receptor expression in cultured cerebellar granule cells may be interrelated and moreover it is likely that the turn-over of GABA receptors is ...

1987-01-01

229

Short-term regulation of muscarinic acetylcholine receptors: An assessment utilizing mouse brain and mouse neuroblastoma cells

Radioiodination of chicken luteinizing hormone without affecting receptor binding potency

The effects of muscarinic agonists and diisopropylfluorophosphate (DFP) on muscarinic receptor density and muscarinic receptor-mediated responses was assessed in mouse brain and mouse neuroblastoma cells (clone N1E-115). Utilizing the antagonist ({sup 3}H)quinuclidinyl benzilate (({sup 3}H)QNB), there was no difference in the maximal binding capacity (B{sub max}) or equilibrium dissociation constant (K{sub d}) between untreated and 24 hour DFP-treated mice. However, one administration of DFP produced a 24% and 33% decrease in B{sub max} measured by ({sup 3}H)N-methylscopolamine (({sup 3}H)NMS) after 18 and 24 hours which was rapidly reversible within 36 hours after DFP treatment. The loss of ({sup 3}H)NMS binding sites following acute DFP treatment was not accompanied by a change in a particular muscarinic receptor binding conformation. Furthermore, the magnitude of muscarinic receptor-mediated ...

1988-01-01

230

Chromosomal localization of the human retinoid X receptors

By improving the currently used lactoperoxidase method, we were able to obtain radioiodinated chicken luteinizing hormone (LH) that shows high specific binding and low nonspecific binding to a crude plasma membrane fraction of testicular cells of the domestic fowl and the Japanese quail, and to the ovarian granulosa cells of the Japanese quail. The change we made from the original method consisted of (1) using chicken LH for radioiodination that was not only highly purified but also retained a high receptor binding potency; (2) controlling the level of incorporation of radioiodine into chicken LH molecules by employing a short reaction time and low temperature; and (3) fractionating radioiodinated chicken LH further by gel filtration using high-performance liquid chromatography. Specific radioactivity of the final {sup 125}I-labeled chicken LH preparation was 14 microCi/micrograms. When specific binding was 12-16%, nonspecific binding was as low as 2-4% in the ...

1989-12-01

231

Performance evaluation of corrosion probes in simulated WVNS tank 8D-2 waste: WVNS tank farm process support

The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In this work, the authors report high-resolution localization of the human RXR genes within cytogenetic bands and also within a standard reference map of cosmid DNA markers on human chromosomes. They have determined the location of the human RXR genes by pairwise hybridization of the RXR cosmids and reference markers, using fluorescence in situ hybridization. They localized (i) RXR[alpha] (RXRA) to chromosome 9 band q34.3; (ii) RXR[beta] (RXRB) to chromosome 6 band 21.3; and (iii) RXR[gamma] (RXRG) to chromosome 1 band q22-q23. Six retinoid-responsive transcription factors have been identified so far, including three retinoic acid receptors in addition to the three RXRs. Interestingly, ...

1994-04-01

232

Molecular characterization of cytoplasmic male sterility conditioned by Gossypium harknessii cytoplasm (CMS-D2) in upland cotton

Five corrosion probes were received from West Valley Nuclear Services for evaluation in simulated tank 8D-2 3rd-stage sludge wash slurry. The same waste slurry simulated was also used in a series of ongoing corrosion studies assessing the effects of in-tank sludge washing on the integrity of tank 8D-2. Two of the corrosion probes were installed in the coupon corrosion test vessels operating at {approximately}150{degrees}F to compare performance of the probes with that observed by coupon tests conducted in the same vessels. Corrosion rate data calculated from electrical resistance measurements of the corrosion probes were evaluated for this study using two slightly different approaches. One approach uses the total length of exposure of the probe to give a ``time-averaged`` value of the corrosion rate. The other approach uses a shorter period of time (relative to the length of the test) in the calculation ...

1994-07-01

233

British Library Electronic Table of Contents (United Kingdom)

Cytoplasmic male sterility (CMS) is a maternally inherited trait that fails to produce functional pollen grains. The CMS system is widely employed to facilitate the utilization of heterosis in major crops. However, little is known about the CMS associated genes in Upland cotton (Gossypium hirsutum). The objective of this study was to compare CMS cotton (CMS-D2) with the cytoplasm from G. harknessii and its isogenic maintainer line with the normal fertile Upland cotton cytoplasm to identify CMS-D2 specific gene(s) and to develop CMS-specific sequence characterized amplified region (SCAR) markers. Based on Southern blot analysis using 10 mitochondrial gene-specific probes (cob, cox2, atp6, atp9, nad3, cox3, atpA, cox1, nad6 and nad9), three probes (cox3, atpA, and nad6) revealed restriction ...

2011-01-01

234

Assessment of RELAP5/MOD3/CANDU"+ to Wolsung-1 D_2O leakage event

In order to evaluate the integrated performance of RELAP5/MOD3/CANDU"+ for CANDU operational transient analysis, we assesed the code to the D_2O leakage event occurred at Wolsung-I, 600 MW(e) CANDU reactor, on Oct. 20, '94. D_2O leakage event was initiated by stuck opening of liquid relief valve No.4 in primary coolant pressure and level control system. Assessment calculation was performed for the plant transients up to 1000 seconds after the initiating event. Calculation results are compared with those measured in primary heat transport system, pressure and inventory control system and boiler secondary system. Comparison with the plant trip log shows that the RELAP5/CANDU"+ is able to simulate the plant transients properly, from which we can conclude that the RELAP5/CANDU"+ is validated for application to CANDU operational transient analysis. CANDU specific models used in the assessment are fuel bundle ...

2001-10-01

235

Strings and QCD

Photo-emission-electron-microscopy for characterization of an operating organic electronic device

We point out that the occurrence of a large-distance ''Coulomb'' term in the static quark-antiquark potential is related to tachyons in the underlying string model. Thus, the tachyon contents determine the coefficient of the ''Coulomb'' term. For a scalar string, one has Luescher's result -(d-2) /24R, for a Neveu-Schwarz string one obtains -(d-2) /16R, whereas for the Ramond string (and strings without tachyons) the ''Coulomb'' term vanishes. Monte Carlo data for QCD prefers a ''Coulomb'' term. This is not inconsistent with the tachyonic origin of this term, since the large-distance behaviour of string models is consistent even with tachyons. Also, critical dimensions are not necessary at large distances.

1985-10-03

236

Exploring the potential energy surface for proton transfer in acetylacetone

Photoemission-electron-microscopy (PEEM) is introduced as a tool for the characterization of organic electronic devices. PEEM-measurements are used for imaging as well as for spectroscopic analyses by illumination with light of a Hg-lamp (4.9 eV), a D2 lamp (7.3 eV), and with synchrotron radiation for resonant photoelectron spectroscopy. We determine the charge carrier concentration inside the channel region of the organic device and its lateral distribution. From resonant photoelectron spectroscopy (RPES) we deduce the electronic states which are accessible with the Hg and D2 illumination. Photoelectron-spectroscopy at selected areas ({mu}-PES) gives information on the absolute values of surface potentials in lateral resolution. We are able to perform these studies with applied voltages at the source- and drain-electrode.

2006-01-20

237

Use of receptor affinity chromatography in purification of the growth hormone-like factor produced by plerocercoids of the tapeworm Spirometra mansonoides.

The portion of the potential energy surface (PES) of acetylacetone relevant for the intramolecular proton transfer reaction is studied using ab initio and DFT methods. The best estimate of the barrier governing proton transfer was found to be 3.4 kcal mol{sup -1} at the MP4(FC)/6-311 + G(2d,2p)//MP2(FC)/6-311 + G(2d,2p) level of theory. Six stationary points on the PES were characterized as well as the reaction paths connecting these points. Special attention paid to the pathway of intramolecular proton transfer reveals that the internal rotation of the methyl group adjacent to the carbonyl group and the proton transfer reaction are consecutive processes.

2004-11-15

238

Topographical distribution of decrements and recovery in muscarinic receptors from rat brains repeatedly exposed to sublethal doses of soman

The plerocercoid stage of the tapeworm Spirometra mansonoides produces a functional analog of human growth hormone (hGH). Among the similarities between plerocercoid growth factor (PGF) and hGH is competition for the same receptors on rabbit liver membranes. To take advantage of this characteristic in a purification scheme for PGF, rabbit liver microsomes were solubilized in Triton X-100 and the hGH receptors were purified over an hGH affinity column. The purified receptors from six rabbit livers were coupled to Affi-Gel-10 to create a receptor affinity column which was used to purify PGF. Chromatography of crude PGF over the receptor column resulted in a 1044 fold increase in specific activity. SDS-PAGE in the presence of 2-mercaptoethanol showed that the affinity-purified PGF contained three protein bands with apparent Mrs of 27.5 K, 22 K, and 16.7 K. Injections of the ...

1988-01-01

239

Topographical distribution of decrements and recovery in muscarinic receptors from rat brains repeatedly exposed to sublethal doses of soman

(3H)Quinuclidinyl benzilate binding to rat brain muscarinic receptors decreased after repeated exposure to soman, a potent organophosphorus cholinesterase inhibitor. The topographical distribution of this decrement was analyzed by quantitative receptor autoradiography. After 4 weeks of soman, three times a week, quinuclidinyl benzilate binding decreased to 67 to 80% of control in frontal and parietal cortex, caudate-putamen, lateral septum, hippocampal body, dentate gyrus, superior colliculus, nucleus of the fifth nerve, and central grey. Minor or no decreases were observed in thalamic or hypothalamic nuclei, reticular formation, pontine nuclei, inferior colliculus, nucleus of the seventh nerve, and cerebellum. Scatchard analyses of saturation curves using frontal cortex sections from soman-treated rats revealed a decrease in maximal quinuclidinyl benzilate binding from that in control rats and a return toward control levels by 24 days without ...

1984-08-01

240

Regulation of NMDA and AMPA receptors during the maturation phase of chicken brain development

[3H]Quinuclidinyl benzilate binding to rat brain muscarinic receptors decreased after repeated exposure to soman, a potent organophosphorus cholinesterase inhibitor. The topographical distribution of this decrement was analyzed by quantitative receptor autoradiography. After 4 weeks of soman, three times a week, quinuclidinyl benzilate binding decreased to 67 to 80% of control in frontal and parietal cortex, caudate-putamen, lateral septum, hippocampal body, dentate gyrus, superior colliculus, nucleus of the fifth nerve, and central grey. Minor or no decreases were observed in thalamic or hypothalamic nuclei, reticular formation, pontine nuclei, inferior colliculus, nucleus of the seventh nerve, and cerebellum. Scatchard analyses of saturation curves using frontal cortex sections from soman-treated rats revealed a decrease in maximal quinuclidinyl benzilate binding from that in control rats and a return toward control levels by 24 days without ...

1984-01-01

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241

Natriuretic peptides in vascular physiology and pathology.

Full text: The maturation of chicken forebrain is protracted and occurs well after synapse formation providing a good model for studying mechanisms of brain maturation. Using microslices from immature (10 day) and adult chicken forebrain prepared after decapitation, we have examined functional properties of NMDA and AMPA receptors by measuring agonist-induced uptake of "4"5Ca"2"+ . The rate and extent of NMDA induced "4"5Ca"2"+ accumulation decreased during maturation with no change in EC_5_0. The rate and extent of the AMPA induced response also decreased with a 60-fold increase in EC_5_0. However, the total NMDA receptor content did not change as indicated by 3 H-MK801 binding and NR1 immunoreactivity in P2 fractions. Similarly, there was no change in the B_m_a_x of "3H-AMPA, though there was a two-fold increase in K_D, and little or no change in the immunoreactivity in GluR1, 2, 2/3 or 4. These results suggest that it is the regulation of ...

2002-02-04

242

In vitro assessment of the agonist properties of the novel 5-HT_1_A receptor ligand, CUMI-101 (MMP), in rat brain tissue

Four major natriuretic peptides have been isolated: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and Dendroaspis-type natriuretic peptide (DNP). Natriuretic peptides play an important role in the regulation of cardiovascular homeostasis maintaining blood pressure and extracellular fluid volume. The classical endocrine effects of natriuretic peptides to modulate fluid and electrolyte balance and vascular smooth muscle tone are complemented by autocrine and paracrine actions that include regulation of coronary blood flow and, therefore, myocardial perfusion; modulation of proliferative responses during myocardial and vascular remodeling; and cytoprotective anti-ischemic effects. The actions of natriuretic peptides are mediated by the specific binding of these peptides to three cell surface receptors: type A natriuretic peptide receptor (NPR-A), type B natriuretic peptide ...

2008-01-01

243

Characterization of histamine H_1-receptor binding peptides in guinea pig brain using ["1"2"5I]iodoazidophenpyramine, an irreversible specific photoaffinity probe

Introduction: Development of agonist positron emission tomography (PET) radioligands for the 5-HT neurotransmitter system is an important target to enable the understanding of human 5-HT function in vivo. ["1"1C]CUMI-101, proposed as the first 5-HT_1_A receptor agonist PET ligand, has been reported to behave as a potent 5-HT_1_A agonist in a cellular system stably expressing human recombinant 5-HT_1_A receptors. In this study, we investigate the agonist properties of CUMI-101 in rat brain tissue. Methods: ["3"5S]-GTP#gamma#S binding studies were used to determine receptor function in HEK (human embryonic kidney) 293 cells transfected with human recombinant 5-HT_1_A receptors and in rat cortex and rat hippocampal tissue, following administration of CUMI-101 and standard 5-HT1A antagonists (5-HT, 5-CT and 8-OH-DPAT). Results: CUMI-101 behaved as an agonist at human recombinant 5-HT_1_A ...

2011-02-01

244

The International Tethered Cord Partnership: Beginnings, process, and status

Aminophenpyramine, a derivative of mepyramine (pyrilamine), a typical antagonists of histamine at its H_1 receptor was synthesized and converted into ["1"2"5I]iodoazidophenpyramine, a potential photoaffinity probe for the H_1 receptor. In the dark, reversible binding of this probe to cerebellar membranes occurred with a K/sub d/ of 1.2 x 10"-"1"1 M and a B/sub max/ of 240 fmol/mg of protein and was inhibited by various H_1-receptor antagonists with the expected potencies. These features establish the compound as one of the most potent H_1-receptor antagonists known so far. Upon IV irradiation, 5% of the bound radioactivity was covalently incorporated into cerebellar membrane polypeptides as shown by standard NaDodSO_4/PAGE. Two bands of 47 and 56 kDa were consistently labeled, labeling being prevented by various H_1-receptor antagonists with the expected potencies and ...

245

The Current Status of Russian/CIS Communication Satellites

Background:Spina bifida presents a significant cause of childhood morbidity in lower- and middle-income nations. Unfortunately, there is a paucity of literature examining...Full Text Available

246

Status of reactor physics in Japan

... 4302, and to the Office of Management and Budget, Paper-work ... link coverage areas, so it is possible to receive your own ... mestic Ku-band satellite. ...

1994-09-01

247

Status of Tern Colonies in the Honduras Bay Islands

Recent achievements and tendency on reactor physics activities in Japan are reviewed according to topics published in journals or discussed at the Japan Research Committee on Reactor Physics.

1988-09-18

248

September 1995 Prototypes and Studies Status

... herbaceous and low succulents (mostly Sesuvium portulacastrum, also Ipomea sp., Euphorbia sp.). Local informants revealed that historic colonies ... vegetation (Sesuvium portulacastrum, Suriana maritima, ...

249

ROSAT Status 130: Update on Wurzburg Conference - HEASARC - NASA

4) Expand to include client-server interaction (small-scale archive interactions with the goal of evaluating information management capabilities) -- Early ...

250

Present status of biochemical research on the insecticide resistance problem*

Aug 21, 1995... F.D. Two Southern Supernova Remnants Shibazaki, N. Effect of a Superfluid- Crust Coupling on the Neutron Star Evolution Siddiqui, ...

251

Overview of Computer Simulation Modeling Approaches and Methods

In order to provide a rational basis for the development of new insecticides, a thorough understanding of resistance mechanisms is necessary and this presupposes a detailed knowledge of the normal...Full Text Available

1963-01-01

252

OPERATIONS AND FURLOUGHS UNDER A GOVERNMENT - NASA

Sep 1, 2011 ... 2005. Computer simulation modeling of recreation use: current status, case studies, and future directions. Gen. Tech. Rep. RMRS-GTR-143. ...

253

Neotype Designation and Redescription of Toumeyella liriodendri (Gmelin) (Hemiptera: Coccoidea: Coccidae)

Apr 7, 2011 ... You cannot be in any type of pay status (e.g., annual leave, sick leave, .... Retirement System (FERS) and the Civil Service Retirement System ...

254

N95- 19645 - NASA Technical Report Server (NTRS)

In order to clarify the taxonomic status and to preserve the stability of the species, a neotype is designated for the tuliptree scale: Coccus liriodendri Gmelin (now Toumeyella...Full Text Available

255

Modern theory of nuclear forces: status and perspectives

Milstar is a flexible, robust satellite communications ... of the Milstar system includes services capable of supporting status reporting, ...

256

Impact on Benefits: Part-Time Schedule

I present and discuss recent results on nuclear forces and few-nucleon systems obtained in the framework of chiral effective nuclear field theory.

2007-06-15

257

Geothermal materials program: strategy. Final report

Jan 31, 2006 ... Sick leave accrues at the rate of 1 hour for each 20 hour in a pay status. ... FERS: All periods of service are used in determining the FERS ...

258

Generation and growth start of stress corrosion cracking. Current status of study of steady growth process and research subjects

The following topics are discussed: program goal and objectives, program organization, and program status. Current program projects are described. (MHR)

1980-10-01

259

GLAST Project Status - NASA

... Masatsune IHI Technology Service Co., Ltd., Yokohama, Kanagawa (Japan)

2005-05-01

260

Current Status of Cognitive Behavioral Therapy for Adult Attention-Deficit Hyperactivity Disorder

Space Network Ku-band service. ... Completed GLAST mission schedule and budget assessment .... Utilize Ku band SN link (TDRSS) for science data return ...

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261

Cross-sectional survey of users of Internet depression communities

SynopsisAttention-deficit / hyperactivity disorder (ADHD) is a valid and impairing psychological disorder that persists into adulthood in a majority of cases and is associated...Full Text Available

2010-09-01

262

Container System Hardware Status Report 1990

BackgroundInternet-based depression communities provide a forum for individuals to communicate and share information and ideas. There has been little research into the health status...Full Text Available

263

Consolidated U.S. nuclear quality assurance standard: present status and application

... was released and three prototype contracts were awarded by TACOM on 18 January 1989, to General Motors Corporation, PACCAR, and Osh Kosh ...

2011-05-14

264

Change Agents Advisory Committee - Goddard Diversity Council - NASA

(1979). United States Bernsen, SA Bechtel Power Corp-USA, Downey, CA

265

Bone geometry, biomechanics, and mineral content of the distal radius in uremic patients with severe hyperparathyroidism

Employees in a pay status earn sick leave at the rate of 4 hours each pay period .... Employees covered by the Federal Employees' Retirement System (FERS) ...

266

Accelerator technology program, January-June 1982. Status report

Bone integrity and mineral status were studied with a noninvasive method in uremic patients with severe secondary hyperparathyroidism undergoing maintenance hemodialysis.

1999-04-01

267

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.

The major projects of the Los Alamos National Laboratory's Accelerator Technology Division are discussed, covering activities that occurred during the first six months of calendar 1982.

268

Insight into Thyroid-Stimulating Autoantibody Interaction with the Thyrotropin Receptor N-Terminus Based on Mutagenesis and Re-Evaluation of Ambiguity in This Region of the Receptor Crystal Structure

Several examples of agonist-directed trafficking of receptor signalling at 5-HT2A and 5-HT2C receptors have been reported that involve independent downstream transduction pathways. We now report the functional selectivity of a series of chemically diverse agonists at human (h)5-HT2A, h5-HT2B and h5-HT2C-VSV by examining two related responses, the upstream activation of Gq/11 proteins in comparison with its associated cascade of calcium mobilisation. At the h5-HT2A receptor, d-lysergic acid diethylamide (LSD) and the antiparkinsonian agents lisuride, bromocriptine and pergolide exhibit a higher potency for Gq/11 activation than calcium release in contrast with all the other tested ligands such as 5-HT, mCPP and BW723C86, that show an opposite preference of signalling pathway. Comparable observations are made at h5-HT2B and h5-HT2C-VSV receptors, suggesting a similar mechanism of functional selectivity ...

2008-07-30

269

British Library Electronic Table of Contents (United Kingdom)

Background: Thyroid-stimulating autoantibodies (TSAb) bind to the thyrotropin receptor (TSHR) extracellular domain, or ectodomain (ECD), comprising a leucine-rich repeat domain (LRD) linked by a hinge region to the transmembrane domain (TMD). The LRD (residues 22???260; signal peptide 1???21) contains two disulfide-bonded loops at its N-terminus. In the crystal structure of the isolated LRD complexed with human TSAb monoclonal antibody (mAb) M22, N-terminal disulfide loop 1 (residues 22???30) could not be determined because of crystal disorder. Nevertheless, present crystal structure data are interpreted to exclude a role for the LRD N-terminal disulfide loops in the TSAb epitope(s), contradicting prior functional evidence of a role for these loops in TSAb function. Materials and Methods: ...

2011-01-01

270

Imaging of gastrinomas by nuclear medicine methods

Generation and Characterization of Monoclonal Antibodies to Human Keratinocyte Growth Factor Receptor

Somatostatin receptor scintigraphy (SRS) is a valuable method for the detection of somatostatin receptor-positive lesions. Most gastrinomas (over-)express the somatostatin receptor subtype 2 which can be targeted by In-111 labeled Octreotide. Different studies show a high sensitivity of SRS for the localization and staging of gastrinomas. SRS seems to be superior to other non-invasive imaging modalities and has been proven to significantly contribute to patient management. However, the sensitivity depends on the size and exact localization of the tumors. Smaller lesions and lesions located in the duodenum show a significantly lower sensitivity. In any case, SRS belongs to the routine imaging procedure for gastrinomas for localization and staging and can also be used for evaluation of the tumor progression. (author)

271

British Library Electronic Table of Contents (United Kingdom)

Keratinocyte growth factor receptor (KGFR) and fibroblast growth factor receptor (FGFR) 2c share identical amino acid sequences, except for a 46-amino acid domain in the extracellular region. Monoclonal antibodies (MAbs) specific to KGFR have not been reported nor are commercially available. In this study, we generated murine MAbs specific to KGFR in non-obese diabetic (NOD) mice using a modified Repeated Immunizations at Multiple Sites (RIMMS) technology. Stable cell lines expressing the full-length human KGFR or FGFR2c were produced to facilitate the identification of KGFR-specific MAbs. Following the initial screening of hybridoma clones with a fluorescence-based, confocal cell detection method and ELISA, KGFR-specific MAbs were selected and confirmed by flow cytometry and Western blot ...

2006-01-01

272

Two dimensional analysis for equilibrium core of CANDU-PHWR

Two dimensional analysis for equilibrium core of CANDU-PHWR

The WBURN (2-D, 2-group, coarse mesh) code is developed to analyze the equilibrium core characteristics of CANDU-PHWR. The equilibrium characteristics of Wolsung reactor computed by using WBURN are compared with the values given in the Wolsung FSR. The changes of equilibrium core characteristics caused by the variation of design parameters for operating conditions are also investigated. The numerical results indicate that the average discharge irradiation in the Wolsung reactor can be increased up to about 5%.

1983-06-01

273

The rare earth antimonates: spectroscopic properties, crystal field and paramagnetic susceptibility simulations

The WBURN (2-D, 2-group, coarse mesh) code is developed to analyze the equilibrium core characteristics of CANDU-PHWR. The equilibrium characteristics of Wolsung reactor computed by using WBURN are compared with the values given in the Wolsung FSR. The changes of equilibrium core characteristics caused by the variation of design parameters for operating conditions are also investigated. The numerical results indicate that the average discharge irradiation in the Wolsung reactor can be increased up to about 5%. (Author).

1983-01-01

274

Temperature coefficient in D_2O moderated reactor (Wolsung Unit 1)

The rare earth antimonates RE_3Sb_5O_1_2 constitute an isostructural series, where the rare earth site symmetry is S_4. The spectroscopic properties of pure or doped compounds of this family are studied in order to derive their energy level schemes and to simulate them through the crystal field theory, by using the approximated D_2_d potential. The paramagnetic susceptibilities are calculated with the derived wavefunctions and compared to experiment.

1990-09-01

275

Solvent isotope effect on the quartet #-># doublet intersystem crossing efficiencies of Cr(bpy)_3"3"+ and Cr(phen)_3"3"+"1

The temperature coefficient has been investigated on the Wolsung nuclear power reactor, in which fuel is natural uranium dioxide and moderator heavy water. The numerical computations are carried out in terms of changes of the effective neutron multiplication factor with respect to fuel, moderator, and coolant temperatures. Those results are compared with the computed values of temperature coefficient based on the LATREP computer code. (author).

1977-01-01

276

Identification of source and recharge zones in an aquifer system from water stable isotope. Case Study Bajo Cauca Antioqueno

The intensity of luminescence from the "2E state of Cr(bpy)_3"3"+ (bpy = 2, 2'-bipyridine) is lower in D_2O, although the "2E lifetime is unchanged, indicating that the "4T_2 (precursor to "2E) is sensitive to the isotopic nature of the solvent. A photophysical mechanism is proposed for Cr(NN)_3"3"+ complexes.

277

HupUV proteins of Rhodobacter capsulatus can bind H2: evidence from the H-D exchange reaction.

Hydrology and hydrogeochemical are auxiliary techniques to valid conceptual hydrogeology an recharge models. Stable isotopes from water trace sources and path flow and Tritium indicates age. This paper is about the use of D 18, D2H y 3H to study the aquifer system on Bajo Cauca antioqueno.

278

Electrodeless, multi-megawatt reactor for room-temperature, lithium-6/deuterium nuclear reactions

The H-D exchange reaction has been measured with the D2-H2O system, for Rhodobacter capsulatus JP91, which lacks the hupSL-encoded hydrogenase, and R. capsulatus BSE16, which lacks the HupUV proteins....Full Text Available

1997-01-01

279

C57BL/6J, DBA/2J, and DBA/2J.Gpnmb⁺ mice have different visual signal processing in the inner retina

This paper describes a reactor design to facilitate a room-temperature nuclear fusion/fission reaction to generate heat without generating unwanted neutrons, gamma rays, tritium, or other radioactive products. The room-temperature fusion/fission reaction involves the sequential triggering of billions of single-molecule, "6LiD 'fusion energy pellets' distributed in lattices of a palladium ion accumulator that also acts as a catalyst to produce the molecules of "6LiD from a solution comprising D_2O, "6LiOD with D_2 gas bubbling through it. The D_2 gas is the source of the negative deuterium ions in the "6LiD molecules. The next step is to trigger a first nuclear fusion/fission reaction of some of the "6LiD molecules, according to the well-known nuclear reaction: "6Li + D #-># 2"4He + 22.4 MeV. The highly energetic alpha ...

280

metabotropic glutamate receptor 5 (mGluR5) has a critical role in inhibitory learning

PurposeTo characterize differences in retinal ganglion cell (RGC) function in mouse strains relevant to disease models. C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse...Full Text Available

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281

Zebrafish TRPA1 Channels are Required for Chemosensation but not for Thermosensation or Mechanosensory Hair Cell Function

The mechanisms that contribute to the extinction of previously acquired memories are not well understood. These processes, often referred to as inhibitory learning, are thought to be parallel...Full Text Available

2009-03-25

282

Vitamin A Enhances Antitumor Effect of a Green Tea Polyphenol on Melanoma by Upregulating the Polyphenol Sensing Molecule 67-kDa Laminin Receptor

Transient receptor potential (TRP) ion channels have been implicated in detecting chemical, thermal and mechanical stimuli in organisms ranging from mammals to Caenorhabditis elegans....Full Text Available

2008-10-01

283

Tumor-derived extracellular mutations of PTPRT/PTP? are deficient in cell adhesion

BackgroundGreen tea consumption has been shown to have cancer preventive qualities. Among the constituents of green tea, (-)-Epigallocatechin-3-O-gallate (EGCG)...Full Text Available

284

Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice

Receptor protein tyrosine phosphatase T (PTPRT/PTPρ) is frequently mutated in human cancers including colon, lung, gastric and skin cancers. More than half of the identified tumor-derived...Full Text Available

2008-07-01

285

Tone-Specific and Nonspecific Plasticity of the Auditory Cortex Elicited by Pseudoconditioning: Role of Acetylcholine Receptors and the Somatosensory Cortex

BackgroundThe dynorphin-kappa opioid receptor (KOR) system regulates glial proliferation after sciatic nerve injury. Here, we investigated its role in cell proliferation following...Full Text Available

286

Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens

Experience-dependent plastic changes in the central sensory systems are due to activation of both the sensory and neuromodulatory systems. Nonspecific changes of cortical auditory neurons elicited by...Full Text Available

2008-09-01

287

The stereospecificity of LY253352 for alpha 1-adrenoceptor binding sites in the brain and prostate.

Recent research has implicated the nucleus accumbens (NAc) in consolidating recently acquired goal-directed appetitive memories, including spatial learning and other instrumental processes. However,...Full Text Available

2005-04-26

288

The potential role of phrenic nucleus glutamate receptor subunits in mediating spontaneous crossed phrenic activity in neonatal rat

1. The stereospecificity of the enantiomers of LY253352, a potent and selective alpha 1-adrenoceptor antagonist, were studied in the human prostate and canine brain using radioligand receptor binding...Full Text Available

1988-09-01

289

The photoaffinity ligand [3,5-"3H] 4-azidoclonidine. Synthesis and characterization details

Cervical spinal cord hemisection rostral to the phrenic nucleus leads to paralysis of the ipsilateral hemidiaphragm in adult rats. Respiratory function can be restored to the paralyzed hemidiaphragm...Full Text Available

2009-08-01

290

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

[3,5-"3H] 4-Azidoclonidine 6 was prepared from [3,5-"3H] 4-aminoclonidine 4 and has emerged as a valuable tool to study the alpha-2-adrenergic receptor. (author)

2004-07-01

291

The mechanism of the radiosensitizing effect of conjugated linoleic acids (CLA) on human colon cancer cells, HT-29: disruption of epidermal growth factor receptor function

Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen...Full Text Available

2009-12-01

292

The effects of histamine and leukotriene receptor antagonism on nasal mannitol challenge in allergic rhinitis

Polish 2010 p. 101 Poland Gradzka, I. Sochanowicz, B. Wojewodzka,

2010-09-20

293

The Receptor Tyrosine Kinase FGFR4 Negatively Regulates NF-kappaB Signaling

AimsIt is unclear as to which mediators are involved in mediating the response to nasal mannitol challenge, a novel osmotic stimulus.MethodsA...Full Text Available

2003-06-01

294

The Case for Selection at CCR5-?32

BackgroundNFκB signaling is of paramount importance in the regulation of apoptosis, proliferation, and inflammatory responses during human development and homeostasis, as...Full Text Available

295

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Δ32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested...Full Text Available

2005-11-01

296

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration*S?

SummaryTRPV1 is the founding and best-studied member of the family of temperature-activated transient receptor potential ion channels (thermoTRPs). Voltage, chemicals, and heat...Full Text Available

2010-06-01

297

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-d-aspartate receptors

Peptide toxins with high affinity, divergent pharmacological functions, and isoform-specific selectivity are powerful tools for investigating the structure-function relationships of voltage-gated...Full Text Available

2008-10-03

298

British Library Electronic Table of Contents (United Kingdom)

The synthesis and structure-activity relationship analysis of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented. Some of the studied compounds are potent, selective, non-competitive, and voltage-independent antagonists of NR2B-containing NMDA receptors. Like the founding member of this class of antagonists (ifenprodil), several interesting compounds of the series bind to the amino terminal domain of the NR2B subunit to inhibit function. Analogue potency is modulated by linker length, flexibility, and hydrogen bonding opportunities. However, unlike previously described classes of NR2B-selective NMDA antagonists that exhibit off-target activity at a variety of monoamine receptors, the compounds described herein show much diminished effects against the...

2009-01-01

299

Synapse-Associated Protein 102/dlgh3 Couples the NMDA Receptor to Specific Plasticity Pathways and Learning Strategies

Steroid hormones and brain development: some guidelines for understanding actions of pseudohormones and other toxic agents.

Understanding the mechanisms whereby information encoded within patterns of action potentials is deciphered by neurons is central to cognitive psychology. The multiprotein complexes formed by...Full Text Available

2007-03-07

300

Somatostatin receptor scintigraphy might be useful for detecting skeleton abnormalities in patients with multiple myeloma and plasmacytoma

Gonadal, adrenal, and thyroid hormones affect the brain directly, and the sensitivity to hormones begins in embryonic life with the appearance of hormone receptor sites in discrete populations of neurons....Full Text Available

1987-10-01

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301

Sigma-1 receptor agonist fluvoxamine for postoperative delirium in older adults: report of three cases

Somatostatin receptor expression has been demonstrated on a number of plasma cell lines. Therefore, we questioned whether somatostatin receptor scintigraphy (SRS) can be used to demonstrate in vivo multiple myeloma (MM) activity. SRS was performed in newly diagnosed (n = 9) or relapsing (n = 18) MM patients or in patients with localized plasmacytoma (n = 2). The results were compared with radiographic findings. A positive SRS was demonstrated in 44% of the newly diagnosed patients, in 83% of the relapsed patients and in both patients with plasmacytoma. The SRS findings corresponded with radiographic abnormalities in 40% of the patients. However, in relapsed patients 60% demonstrated increased SRS uptake in areas without new radiographic abnormalities. The positive SRS corresponded with histologically proven disease activity and responded upon treatment. Moreover, immunohistochemical staining of MM material demonstrated concordant somatostatin ...

2010-01-01

302

Serum RANKL, osteoprotegerin (OPG), and RANKL/OPG ratio in nephrotic children

BackgroundPostoperative delirium is a topic of great importance in the geriatric surgical specialty. Although antipsychotic drugs are the medications most frequently used to treat...Full Text Available

303

Serum HER2 Level Measured by Dot Blot: A Valid and Inexpensive Assay for Monitoring Breast Cancer Progression

Receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) play key roles in the pathogenesis of glucocorticoid-induced osteoporosis (GIO). The aim of our study was to determine whether the...Full Text Available

2010-10-01

304

Selective imaging of adherent targeted ultrasound contrast agents

Human epidermal growth factor receptor 2 (HER2) is one of the most important prognostic and predictive factors for breast cancer patients. Recently, serum HER2...Full Text Available

305

Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes

The goal of ultrasonic molecular imaging is the detection of targeted contrast agents bound to receptors on endothelial cells. We propose imaging methods that can distinguish adherent microbubbles...Full Text Available

2007-04-21

306

STIMULATION OF TARSAL RECEPTORS OF THE BLOWFLY BY ALIPHATIC ALDEHYDES AND KETONES

Background:Endothelin-1 may be involved in the development of diabetic microangiopathy. We studied the effect of endothelin-1 blockade on myocardial microcirculation during coronary...Full Text Available

2009-01-01

307

Role of adenosine in regulating glucose uptake during contractions and hypoxia in rat skeletal muscle

Rejection of eight aldehydes, eight ketones, five secondary alcohols, and 3-pentanol has been studied in the blowfly Phormia regina Meigen. The data agree with results previously reported...Full Text Available

1949-03-20

308

Role of Estrogen Receptor-? in the Regulation of Claudin-6 Expression in Breast Cancer Cells

The effect of A₁-adenosine receptor antagonism via 8-cyclopentyl-1,3-dipropyl-xanthine (CPDPX) on the stimulation of skeletal muscle glucose uptake by...Full Text Available

1999-02-15

309

Residence time probability analysis of sulfur concentrations at Grand Canyon National Park

PurposeIn our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration-...Full Text Available

2011-03-01

310

Radiolabelled D/sub 2/ agonists as prolactinoma imaging agents: Progress report for period February 1, 1988--January 31, 1989

A statistical method is developed to determine the locations of major pollutant sources affecting a distant downwind receptor, provided that air trajectories can be estimated. Probability density functions are estimated which indicate the overall residence time of air parcels over a given geographic region as they travel toward a receptor and residence time for the case of high pollutant concentrations at the receptor. These functions are used to estimate a conditional probability function which indicates the potential for a source region to contribute to high air pollution concentrations. Finally, a source contribution function is formulated to indicate the relative contribution of different source regions to high concentrations at the receptor. The method is tested using data collected at Grand Canyon National Park in 1980. The dominant pathway for air masses arriving at Grand Canyon during this ...

1985-01-01

311

RXR activators molecular signalling: involvement of a PPAR?-dependent pathway in the liver and kidney, evidence for an alternative pathway in the heart

Targeted studies completed include the evaluation of tritiated N-0437, evaluation of /sup 35/S-cysteamine, evaluation of /sup 18/F-FDG and initiation of synthetic efforts towards the synthesis of iodinated N-0437 and pergolide analogs. The direction of the project has been changed due to several factors which include the decided lack of favorable experimental results, the excellence of results using muscarinic receptor ligands in pituitary, brain and heart and the contention of the DOE review panel that the original grant proposal was based on flawed assumptions together with their perceived lack of importance to pituitary imaging. In the final year of this grant, three studies will be completed. The first study is the continuation of synthetic efforts to prepare iodinated N-0437 and pergolide analogs for possible use as brain imaging agents. The second study is directed towards completion of biochemical evaluation of various muscarinic ...

1988-10-15

312

RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice

In this study we compared the molecular signalling elicited by rexinoids, selective retinoid X receptor (RXR)-activators, in several organs (i.e. liver, kidney,...Full Text Available

2003-03-01

313

Putative Biomarkers and Targets of Estrogen Receptor Negative Human Breast Cancer

BackgroundGlucocorticoids down-regulate cytokine synthesis and suppress inflammatory responses. The glucocorticoid receptor (GR) antagonist RU486 may exacerbate the inflammatory...Full Text Available

314

Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2

Breast cancer is a progressive and potentially fatal disease that affects women of all ages. Like all progressive diseases, early and reliable diagnosis is the key for successful treatment and annihilation....Full Text Available

315

Prognostic Significance of Peritumoral Lymphatic Vessel Density and Vascular Endothelial Growth Factor Receptor 3 in Invasive Squamous Cell Cervical Cancer

BackgroundThe lactogenic hormones prolactin (PRL) and placental lactogens (PL) play central roles in reproduction and mammary development. Their actions are mediated via binding...Full Text Available

316

Pretreatment with a soluble activin type IIB receptor/Fc fusion protein improves hypoxia-induced muscle dysfunction

Cervical cancer is known to metastasize primarily by the lymphatic system. Dissemination through lymphatic vessels represents an early step in regional tumor progression, and the presence of lymphatic...Full Text Available

317

Prenatal cocaine reduces AMPA receptor synaptic expression through hyperphosphorylation of the synaptic anchoring protein GRIP

Hypoxia, or reduced oxygen, occurs in a variety of clinical and environmental situations. Hypoxic exposure is associated with decreased muscle mass and a concomitant reduction in exercise capacity,...Full Text Available

2010-01-01

318

Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.

Prenatal cocaine exposure produces sustained neurobehavioral and brain synaptic changes closely resembling those of animals with defective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic...Full Text Available

2009-05-13

319

Plasma membrane as the target site of cholic acid analogs.

Cleavage of membrane-associated proteins with the release of biologically active macromolecules is an emerging theme in biology. However, little is known about the nature and regulation of the involved...Full Text Available

1996-07-23

320

Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with hepatic or renal impairment: two open-label comparative studies

Although the mechanism is unknown, Calculus Bovis and its active components, cholic acid analogs (CAAs), have been used in China to treat a wide range of diseases. Based on the previous finding that the potency of CAA is strongly dependent on the intrinsic surface activity, this paper aimed to investigate the role of the plasma membrane in the pharmacological activity of CAAs. First, CAAs (0.1 mM) caused a surface activity-dependent depression on ATPase activity in the cell membrane extract, but it had no effects on other cellular extracts, suggesting an indispensable role of the membrane environment for pharmacological activity. Second, CAAs lowered the membrane fluidity of cultured Caco-2 cells with the same rank-order of potency sequence. Third, the hypothesis that any functional protein located on the membrane is influenced by changes in cellular membrane fluidity was supported by: ileal contraction that was induced by acetylcholine and mediated by the muscarinic ...

2011-08-03

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321

Parallel helix bundles and ion channels: molecular modeling via simulated annealing and restrained molecular dynamics.

BackgroundZibotentan (ZD4054) is a specific endothelin A (ET_A) receptor antagonist being investigated for the treatment of prostate cancer. As zibotentan is eliminated...Full Text Available

322

Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis

A parallel bundle of transmembrane (TM) alpha-helices surrounding a central pore is present in several classes of ion channel, including the nicotinic acetylcholine receptor (nAChR). We have modeled...Full Text Available

1994-10-01

323

P2Y₂ Nucleotide Receptor-Mediated Responses in Brain Cells

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor survival. The identification of therapeutic targets is essential to improving outcomes. Previous studies found that expression...Full Text Available

2011-03-31

324

Ontogenetic Profile of the Expression of Thyroid Hormone Receptors in Rat and Human Corpora Cavernosa of the Penis

Acute inflammation is important for tissue repair; however, chronic inflammation contributes to neurodegeneration in Alzheimer’s disease (AD) and occurs when glial cells undergo prolonged...Full Text Available

2010-06-01

325

Nuclear receptor ERR? and coactivator PGC-1? are effectors of IFN-?-induced host defense

IntroductionIn the last few years, various studies have underlined a correlation between thyroid function and male sexual function, hypothesizing a direct action of thyroid hormones...Full Text Available

2010-04-01

326

Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina

Macrophage activation by the proinflammatory cytokine interferon-γ (IFN-γ) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature...Full Text Available

2007-08-01

327

Noradrenergic ?₁ Receptors as a Novel Target for the Treatment of Nicotine Addiction

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated...Full Text Available

328

Nonsteroidal Selective Androgen Receptor Modulators Enhance Female Sexual Motivation

Nicotine is the main psychoactive ingredient in tobacco and its rewarding effects are considered primarily responsible for persistent tobacco smoking and relapse. Although dopamine has been extensively...Full Text Available

2010-07-01

329

Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A₁ receptor in a manner different from its classical agonists

Women experience a decline in estrogen and androgen levels after natural or surgically induced menopause, effects that are associated with a loss of sexual desire and bone mineral density. Studies in...Full Text Available

2010-08-01

330

Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS?

The effects of paeoniflorin (PF), a compound isolated from Paeony radix, on neurological impairment and histologically measured infarction volume...Full Text Available

2005-10-01

331

NMDA Receptor Blockade with Memantine Attenuates White Matter Injury in a Rat Model of Periventricular Leukomalacia

The CNS can exhibit features of inflammation in response to injury, infection or disease, whereby resident cells generate inflammatory mediators, including cytokines, prostaglandins, free radicals and...Full Text Available

2010-08-01

332

Myelin associated glycoprotein cross-linking triggers its partitioning into lipid rafts, specific signaling events and cytoskeletal rearrangements in oligodendrocytes

Hypoxia–ischemia (H/I) in the premature infant leads to white matter injury termed periventricular leukomalacia (PVL), the leading cause of subsequent neurological deficits. Glutamatergic...Full Text Available

2008-06-25

333

Molecular conformation, receptor binding, and hormone action of natural and synthetic estrogens and antiestrogens.

Myelin-associated glycoprotein (MAG) has been implicated in inhibition of nerve regeneration in the CNS. This results from interactions between MAG and the Nogo receptor and gangliosides on...Full Text Available

2004-02-01

334

Molecular Mechanistic Insights into the Endothelial Receptor Mediated Cytoadherence of Plasmodium falciparum-Infected Erythrocytes

The X-ray crystallographic structural determinations of synthetic estrogens and antiestrogens provide reliable information on the global minimum energy conformation of these molecules or a local minimum...Full Text Available

1985-09-01

335

Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides

Cytoadherence or sequestration is essential for the pathogenesis of the most virulent human malaria species, Plasmodium falciparum (P. falciparum). Similar to leukocyte-endothelium...Full Text Available

336

Microglial Fc Receptors Mediate Physiological Changes Resulting From Antibody Cross-Linking of Myelin Oligodendrocyte Glycoprotein

Human skin is a local source of corticotropin-releasing hormone (CRH) and expresses CRH and CRH receptors (CRH-R) at mRNA and protein levels. Epidermal melanocytes respond to CRH by induction...Full Text Available

2006-05-01

337

MFR, a Putative Receptor Mediating the Fusion of Macrophages

Antibodies to myelin oligodendrocyte glycoprotein (MOG) have been implicated in Multiple Sclerosis demyelination through activation of complement and/or macrophage-effector processes. We presented...Full Text Available

2008-05-30

338

Long-Lasting Adaptations of the NR2B-containing NMDA Receptors in the Dorsomedial Striatum Play a Crucial Role in Alcohol Consumption and Relapse

We had previously identified a macrophage surface protein whose expression is highly induced, transient, and specific, as it is restricted to actively fusing macrophages in vitro and in vivo. This protein...Full Text Available

1998-11-01

339

Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2

A growing number of studies suggest that the development of compulsive drug seeking and taking depends on dorsostriatal mechanisms. We previously observed that ex vivo acute...Full Text Available

2010-07-28

340

Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages?

In addition to its role in megakaryocyte production, signaling initiated by thrombopoietin (TPO) activation of its receptor, myeloproliferative leukemia virus protooncogene (c-Mpl, or Mpl), controls...Full Text Available

2008-08-01

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341

Lack of Association Between Prokineticin 2 Gene and Japanese Methamphetamine Dependence

Host cells use metabolic signaling through the LXRα nuclear receptor to defend against Listeria monocytogenes infection. 25-Hydroxycholesterol is a natural ligand of LXRs that...Full Text Available

2011-04-01

342

JAK/STAT Pathways in Cytokine Signaling and Myeloproliferative Disorders

Disruption of circadian rhythms may be involved in the pathophysiology of psychiatric disorders, including drug addiction. Recently, we detected the significant association between prokineticin 2 receptor...Full Text Available

2011-03-01

343

Interaction of Platelet Membrane Receptors with von Willebrand Factor, Ristocetin, and the Fc Region of Immunoglobulin G

Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Studies conducted over the past 10 to 15 years have revealed that...Full Text Available

2010-10-01

344

Interaction between Bluetongue virus outer capsid protein VP2 and vimentin is necessary for virus egress

The agglutination of human platelets by ristocetin and von Willebrand factor was inhibited by aggregated immunoglobulin (Ig)G and by Fc fragments of IgG, but not by Fab, F(ab′)₂ or...Full Text Available

1978-11-01

345

Insulin receptor signaling in the development of neuronal structure and function

BackgroundThe VP2 outer capsid protein Bluetongue Virus (BTV) is responsible for receptor binding, haemagglutination and eliciting host-specific immunity. However, the assembly of...Full Text Available

346

Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice

Sensory experience plays a crucial role in regulating neuronal shape and in developing synaptic contacts during brain formation. These features are required for a neuron to receive, integrate, and transmit...Full Text Available

347

Immunolocalization of endothelin-B receptor in mouse intestinal tract.

Hyperproliferation of the colonic epithelium, leading to expansion of colonic crypt progenitors, is a recognized risk factor for colorectal cancer. Overexpression of progastrin, a nonamidated and incompletely...Full Text Available

2009-09-01

348

Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration

The endothelin-B (ETB) receptor is a G-protein-coupled receptor that binds endothelin ligands and is essential for the development of epidermal melanocytes and enteric neurons. Recent reports indicate that ETB is localized to nuclei in cardiac ventricular myocytes, although it has been thought that ETB is localized mainly on the plasma membrane. It remains unknown, however, whether this unique distribution of ETB occurs in other tissues. To elucidate the subcellular distribution of ETB in the intestine, we performed immunofluorescence of ETB in mouse intestine using a specific antibody. ETB-like immunoreactivity was detected in both the mucosal and muscle layers. In the mucosal layer, villous epithelial cells, stromal cells of the lamina propria, and cryptic cells were immunostained. Subcellularly, ETB is localized mainly to the nuclei of villous epithelial cells. In the muscle layer, immunoreactivity of ETB was localized to the myenteric ...

2004-11-01

349

Identification and characterization of Aedes aegypti aminopeptidase N as a putative receptor of Bacillus thuringiensis Cry11A toxin

Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer therapy. In addition to the transmembrane...Full Text Available

2009-07-01

350

Human placental transport of cimetidine.

Bacillus thuringiensis subsp. israelensis, which is used worldwide to control Aedes aegypti larvae, produces Cry11Aa and other toxins during...Full Text Available

2009-10-01

351

Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors

This study addresses the mechanism of transport of the H2-receptor antagonist, cimetidine, by the human placenta. A 4-h recycling perfusion of a single placental cotyledon of normal, term, human placenta...Full Text Available

1987-11-01

352

Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system

Histamine has been proposed to be an important regulator of energy intake and expenditure. The aim of this study was to evaluate histamine regulation of glucose and lipid metabolism and development...Full Text Available

2010-08-01

353

Glutamate Receptor-Mediated Restoration of Experience-Dependent Place Field Expansion Plasticity in Aged Rats

Recently, we demonstrated that the central ghrelin signalling system, involving the ghrelin receptor (GHS-R1A), is important for alcohol reinforcement. Ghrelin targets a key mesolimbic circuit involved...Full Text Available

2011-01-01

354

Genetic Elucidation of Human Hyperosmia to Isovaleric Acid

Place fields of hippocampal pyramidal cells expand asymmetrically when adult rats repeatedly follow the same route. This behaviorally-induced expression of neuronal plasticity utilizes an NMDA_R-dependent,...Full Text Available

2008-06-01

355

Gene-silencing reveals the functional significance of pheromone biosynthesis activating neuropeptide receptor (PBAN-R) in a male moth

The genetic basis of odorant-specific variations in human olfactory thresholds, and in particular of enhanced odorant sensitivity (hyperosmia), remains largely unknown. Olfactory receptor (OR) segregating...Full Text Available

2007-11-01

356

Gadolinium-containing phosphatidylserine liposomes for molecular imaging of atherosclerosis

The role of pheromone biosynthesis activating neuropeptide (PBAN) in the regulation of pheromone biosynthesis of several female moth species is well elucidated, but its role in the males has been a...Full Text Available

2010-09-28

357

Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages

Exteriorized phosphatidylserine (PS) residues in apoptotic cells trigger rapid phagocytosis by macrophage scavenger receptor pathways. Mimicking apoptosis with liposomes containing PS may represent...Full Text Available

2009-11-01

358

Functional significance of UDP-glucuronosyltransferase (UGT) variants in the metabolism of active tamoxifen metabolites

Dectin-1, the major β-glucan receptor in leukocytes, triggers an effective immune response upon fungal recognition. Here we use sortase-mediated transpeptidation, a technique that allows placement...Full Text Available

2011-08-23

359

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis

Tamoxifen (TAM) is a selective estrogen receptor modulator widely used in the prevention and treatment of breast cancer. A major mode of metabolism of the major active metabolites of TAM, 4-OH-TAM...Full Text Available

2009-03-01

360

Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors

Fibroblast growth factor (FGF) signaling is involved in skeletal development of the vertebrate. Gain-of-function mutations of FGF receptors (FGFR) cause craniosynostosis, premature fusion of the skull,...Full Text Available

2002-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

EphB Receptors Couple Dendritic Filopodia Motility to Synapse Formation

BackgroundLeukotrienes (LTs) belong to the large family of lipid mediators implicated in various inflammatory conditions such as asthma and rheumatoid arthritis. Four distinct types...Full Text Available

362

Eosinophils Utilize Multiple Chemokine Receptors for Chemotaxis to the Parasitic Nematode Strongyloides stercoralis

SUMMARYMotile dendritic filopodial processes are thought to be precursors of spine synapses, but how motility relates to cell-surface cues required for axon-dendrite recognition...Full Text Available

2008-07-10

363

Effects of Long-Term Pioglitazone Treatment on Peripheral and Central Markers of Aging

Protective innate immunity to the nematode Strongyloides stercoralis requires eosinophils in the parasite killing process. Experiments were performed to determine if an extract of S....Full Text Available

2009-10-01

364

Effective In Vitro Clearance of Porphyromonas gingivalis by Fc? Receptor I (CD89) on Gingival Crevicular Neutrophils

BackgroundThiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARγ) and are used clinically to help restore peripheral insulin sensitivity...Full Text Available

365

Effect of differentiation on specific receptor sites and endocytosis of transferrin in a cell (HT-29) derived from human colic adenocarcinoma

Porphyromonas gingivalis has been implicated as a causative pathogen in periodontitis. Immunotherapeutic approaches have recently been suggested to aid in the clearance of P....Full Text Available

2001-05-01

366

Effect of Peroxisome Proliferator-Activated Receptor Gamma Agonist (Pioglitazone) and Methotrexate on Disease Activity in Rheumatoid Arthritis (Experimental and Clinical Study)

The specific receptor sites and the endocytosis of transferrin (Tf) are evidenced in a cell line (HT-29) derived from a human colic adenocarcinoma by means of "1"2"5I radiolabeled Tf. The receptor density is studied in undifferentiated (UD) or differentiated (D) cells with respective doubling times of about 24 hours and 46 hours. The number of binding sites for Tf is 162,000 (K_d = 7.8 nmol/l in ND cells and 68,000 (K_d = 7.40 nmol/l) in D cells. The distribution between the Tf bound to the cell surface and the internalized Tf is investigated by elimination of Tf bound to the surface by an acid wash method. The intracellular cycle of Tf seems to be characterized by a slower kinetics in UD cells. The high density of Tf receptor sites in HT-29 UD cells should allow the detection or the treatment of highly evolutive colic adenocarcinoma by means of Tf.

367

Editing Antigen Presentation: Antigen Transfer between Human B Lymphocytes and Macrophages Mediated by Class A Scavenger Receptors1

Objective:To investigate the combined effect of both pioglitazone and methotrexate on disease activity of rheumatoid arthritis in a biphasic study; experimental and clinical.Methods:Experimentally:...Full Text Available

368

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Anti-Lipogenic Therapy

B lymphocytes can function independently as efficient APCs. However, our previous studies demonstrate that both dendritic cells and macrophages are necessary to propagate immune responses initiated...Full Text Available

2008-09-15

369

Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state

Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma,...Full Text Available

370

Differential recognition of viral RNA by RIG-I

BackgroundThe N-methyl-D-aspartate (NMDA)-type glutamate receptor expressed at excitatory glutamatergic synapses is required for learning and memory and is critical for normal brain...Full Text Available

371

DIFFERENTIAL EXPRESSION OF HPA AXIS HOMOLOG IN THE SKIN

Retinoic acid inducible gene I (RIG-I) is a pattern recognition receptor (PRR) responsible for detection of nucleic acids from pathogens in the cytoplasm of infected cells and induction of type I interferon...Full Text Available

2011-03-01

372

Cytokinin-Dependent Photorespiration and the Protection of Photosynthesis during Water Deficit1[W][OA

SummaryHuman skin expresses elements of the hypothalamo-pituitary-adrenal (HPA) axis including pro-opiomelanocortin (POMC), corticotropin releasing hormone (CRH), the CRH receptor-1...Full Text Available

2007-02-01

373

Cyclophilin B Interacts with Sodium-Potassium ATPase and Is Required for Pump Activity in Proximal Tubule Cells of the Kidney

We investigated the effects of P_SARK∷IPT (for Senescence-Associated Receptor Kinase∷Isopentenyltransferase) expression and cytokinin production...Full Text Available

2009-07-01

374

Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families

Cyclophilins (Cyps), the intracellular receptors for Cyclosporine A (CsA), are responsible for peptidyl-prolyl cis-trans isomerisation and for chaperoning several membrane proteins. Those functions...Full Text Available

375

Co-localization of Sorting Nexin 2 and Androgen Receptor in the Song System of Juvenile Zebra Finches

BackgroundMost rapidly evolving gene families are involved in immune responses and reproduction, two biological functions which have been assigned to the carcinoembryonic antigen...Full Text Available

376

Chimeric Antigen Receptor Therapy for B-cell Malignancies

Mechanisms regulating sexual differentiation of the zebra finch song system appear to include both genetic and hormonal factors. Sorting Nexin 2 (SNX2), which is involved in trafficking proteins...Full Text Available

2010-07-09

377

Characterization of Cytokinin and Adenine Transport in Arabidopsis Cell Cultures1[OA

We presented data showing that the CART-19 cells expressing the 4-1BB signaling domain can have unprecedented and massive in-vivo expansion, traffic to tumor sites, persist long term in vivo, and induce...Full Text Available

378

Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins

Cytokinins are distributed through the vascular system and trigger responses of target cells via receptor-mediated signal transduction. Perception and transduction of the signal can occur at the plasma...Full Text Available

2008-12-01

379

Catabolite Repression of the Citrate Fermentation Genes in Klebsiella pneumoniae: Evidence for Involvement of the Cyclic AMP Receptor Protein

Cd36 is a small-molecular-weight integral membrane protein expressed in a diverse, but select, range of cell types. It has an equally diverse range of ligands and physiological functions, which has...Full Text Available

2007-11-01

380

Calcium/Calmodulin-Dependent Protein Kinase II Mediates Hippocampal Glutamatergic Plasticity During Benzodiazepine Withdrawal

Klebsiella pneumoniae is able to grow anaerobically with citrate as a sole carbon and energy source by a fermentative pathway involving the Na⁺-dependent citrate...Full Text Available

2001-09-01

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381

Calcium, Vitamin D, VDR Genotypes, and Epigenetic and Genetic Changes in Rectal Tumors

Benzodiazepine withdrawal anxiety is associated with potentiation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) currents in hippocampal CA1 pyramidal...Full Text Available

2010-08-01

382

CRF receptors in the nucleus accumbens modulate partner preference in prairie voles

Calcium, vitamin D, exposure to sunshine, and vitamin D receptor (VDR) genotypes have been associated rectal cancer. We used data from 750 rectal tumors and 1,205 population-based...Full Text Available

2010-05-01

383

CD44 as a receptor for colonization of the pharynx by group A Streptococcus

Recent evidence suggests a role for corticotropin-releasing factor (CRF) in the regulation of pair bonding in prairie voles. We have previously shown that monogamous and non-monogamous vole...Full Text Available

2007-04-01

384

Breast Cancer Stem-Like Cells Are Inhibited by a Non-Toxic Aryl Hydrocarbon Receptor Agonist

The pharynx is the primary reservoir for strains of group A Streptococcus (GAS) associated both with pharyngitis (streptococcal sore throat) and with invasive or “flesh-eating”...Full Text Available

2000-10-15

385

Bacterial Particle Endocytosis by Epithelial Cells Is Selective and Enhanced by Tumor Necrosis Factor Receptor Ligands?

BackgroundCancer stem cells (CSCs) have increased resistance to cancer chemotherapy. They can be enriched as drug-surviving CSCs (D-CSCs) by growth with chemotherapeutic drugs, and/or...Full Text Available

386

Atrial natriuretic peptide signal pathway upregulated in stomach of streptozotocin-induced diabetic mice

Bacterial pathogens use virulence strategies to invade epithelial barriers, but active processes of epithelial cells may also contribute to the endocytosis of microbial particles. To focus on the latter,...Full Text Available

2009-03-01

387

Association Study of Serine Racemase Gene with Methamphetamine Psychosis

AIM: To investigate atrial natriuretic peptide (ANP) secretion from gastric mucosa and the relationship between the ANP/natriuretic peptide receptor type A (NPR-A) pathway and diabetic gastroparesis.METHODS:...Full Text Available

2010-01-07

388

Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand

Experimental studies have demonstrated that not only dopaminergic signaling but also glutamatergic/NMDA receptor signaling play indispensable roles in the development of methamphetamine psychosis. Our...Full Text Available

2011-03-01

389

Angiotensin II Promotes Development of the Renal Microcirculation through AT₁ Receptors

We investigated the ability of N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide...Full Text Available

2004-08-01

390

Analysis of Protein Covalent Modification by Xenobiotics using a Covert Oxidatively Activated Tag

Pharmacologic or genetic deletion of components of the renin-angiotensin system leads to postnatal kidney injury, but the roles of these components in kidney development are unknown. To test the hypothesis...Full Text Available

2010-03-01

391

Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study

Numerous xenobiotics, including therapeutics agents, are substrates for bioactivation to electrophilic reactive intermediates that may covalently modify biomolecules. Selective estrogen receptor...Full Text Available

2005-09-01

392

Activation of PPAR? induces profound multilocularization of adipocytes in adult mouse white adipose tissues

BackgroundMale infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding...Full Text Available

393

Ability of complement to release systemic lupus erythematosus immune complexes from cell receptors.

We sought to determine the effects of activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) on multilocularization of adipocytes in adult white adipose tissue (WAT). Male...Full Text Available

2009-12-31

394

A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention

Endogenous immune complexes present in sera from 10 different patients with systemic lupus erythematosus (SLE) in an active phase were allowed to bind to Raji cells; the ability of intact complement...Full Text Available

1981-05-01

395

A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors

BackgroundCentrosome aberrations can cause genomic instability and correlate with malignant progression in common human malignancies such as breast and prostate cancer. Deregulation...Full Text Available

396

A homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, ? cell hyperplasia, and islet cell tumor

The ventromedial hypothalamus (VMH) plays a central role in the regulation of the female reproductive behavior lordosis, a behavior dependent upon the sequential activation of receptors for the ovarian...Full Text Available

2000-11-07

397

A Comparison of intra-oral digital imaging modalities: Charged Couple Device versus Storage Phosphor Plate

ObjectiveThe goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic α cell hyperplasia...Full Text Available

2009-11-01

398

Status of the Oak Ridge spallation neutron source (ORSNS) project

BackgroundThis in vitro study was conducted to compare the accuracy of two digital image receptors in identifying the location of tip of a fine endodontic file and radiographic apex...Full Text Available

2010-11-01

399

Status of neutron cross sections for reactor dosimetry

The current status and future plans of the Ok Ridge Spallation Neutron Source (ORSNS) are reviewed. The ORSNS is a new project initiated by the U.S. Department of Energy (DOE) beginning October 1, 1995, to prepare the conceptual for a new spallation neutron source. (author) 2 refs.

1995-11-01

400

Status of LBL/LLNL FEL (free electron laser) research for two beam accelerator applications

The status of neutron activation cross sections for some threshold reactions important for reactor materials dosimetry is reviewed. An attempt is made to understand and explain discrepancies between integral and differential data, using recent available experimental results. The importance of standard and benchmark neutron fields for testing differential data for reactor dosimetry is emphasized and the Interlaboratory Reaction Rate (ILRR) program, as well as a similar program pursued by the IAEA, are briefly described.

1976-07-06

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Status and perspectives of short baseline studies

We review the status of free electron laser (FEL) research being conducted at LBL and LLNL as part of a broader program of research on two beam accelerators (TBAs). Induction accelerator-driven FELs for use as power sources for high-gradient accelerators are discussed, along with preliminary cost estimates for this type of power source. Finally, a promising new version of an FEL/TBA is described. 25 refs., 1 fig., 3 tabs.

1989-03-01

402

Rural Education in Tasmania.

The study of flavor changing neutrinos is a very active field of research. I will discuss the status of ongoing and near term experiments investigating neutrino properties at short distances from the source. In the next few years, the Double Chooz, RENO and Daya Bay reactor neutrino experiments will start looking for signatures of a non-zero value of the mixing angle $\\theta_{13}$ with much improved sensitivities. The MiniBooNE experiment is investigating the LSND anomaly by looking at both the $\

2009-01-01

403

Renewable energies in France: the main 2001 results; Les energies renouvelables en France: les principaux resultats en 2001

Addresses factors affecting rural education in Tasmania (Australia), including population trends, financial support, student enrollment, socioeconomic status of rural residents, and geographic isolation. Issues that need to be addressed include the status of small schools in Tasmania, costs associated with transporting students, staffing, low student retention, and limited availability of special services. (LP)

1996-12-01

404

IEEE 8023 ethernet, current status and future prospects at the LHC

This 2001 status on the use of renewable energies in France makes a synthesis of the electric and heat productions of renewable origin. It lists the primary or secondary productions of renewable energies, and details the uses corresponding to each renewable energy production source and their respective satisfaction of consumer's needs (residential, industry and agriculture sectors). A detail statistical status for 1999, 2000 and 2001 is presented in tables. (J.S.)

2002-05-01

405

Evaluation of the SYNTHOIL process. Volume II. Status of development. [47 refs

The status of the IEEE 802.3 standard is reviewed and prospects for the future, including the new 10 Gigabit version of Ethernet, are discussed. The relevance of Ethernet for experiments at the CERN Large Hadron Collider is considered, with emphasis on on-line applications and areas which are technically challenging. 8 Refs.

2000-01-01

406

Beam-beam compensation activities at Fermilab. R and D status

The Synthoil process for producing heavy desulfurized fuel oil from coal has been under development at Pittsburgh Energy Research Center since 1969. The status of development and technical feasibility of the process are reviewed. This is part of an engineering and economic evaluation based on the conceptual design of a 100,000-bbl/day commercial Synthoil facility. Experimental data are discussed with regard to their adequacy for the formulation of a basis for the process design of such a facility. Potential engineering and equipment problems are analyzed.

1977-06-01

407

PPAR action in insulin resistance unraveled by metabolomics: potential clinical implications.

The beam-beam interaction in the Tevatron produce the betatron tune spread in each bunch and a bunch-to-bunch tune spread. The tune spread sets limits on bunch intensity and luminosity. The beam-beam effects for antiprotons are usually more severe since the proton bunch population is higher. The beam-beam effects for antiprotons can in principle be compensated with the use of an electron beam with a corresponding charge density. The status of studies of possibilities of the beam-beam compensation is reviewed in this paper.

1999-06-09

408

Immunity and tolerance to infections in experimental hematopoietic transplantation

ABSTRACT: Metabolomic analysis will provide the next large set of clues to further our understanding of human health and disease. A recent study has elucidated the significant differences in the metabolomes of adipocytes, serum and an adipocyte cell line after activation of two nuclear receptors, peroxisome proliferator activated receptor ?/? (PPAR?/?) and PPAR?. These findings hold great promise for explaining fundamental differences in the mechanisms of PPAR agonists and for identifying targets for the treatment of diabetes.See related research article: http://genomebiology.com/2011/12/8/R75. PMID:21861850

2011-08-23

409

British Library Electronic Table of Contents (United Kingdom)

Resistance and tolerance are two types of host defense mechanisms that increase fitness in response to fungi. Several genetic polymorphisms in pattern recognition receptors, most remarkably Toll-like receptors (TLRs), have been described to influence resistance and tolerance to aspergillosis in distinct clinical settings. TLRs on dendritic cells pivotally contribute in determining the balance between immunopathology and protective immunity to the fungus. Epithelial cells also contribute to this balance via selected TLRs converging on indoleamine-2,3-dioxygenase (IDO). Studies in experimental hematopoietic transplantation confirmed the dichotomy of pathways leading to resistance and tolerance to the fungus providing new insights on the relative contribution of the hematopoietic/nonhematopoi...

2011-01-01

410

Design of a new serotonin receptor 5-HT_1_A imaging agent based on "9"9"mTc

A case study of trastuzumab treatment for metastatic breast cancer in pregnancy: fetal risks and management of cerebral metastases

Serotonin is one of the neurotransmitters found in the brain and mediates brain functions. It is very well known that serotonin related brain abnormalities are exerted mainly via serotonin receptors in a similar manner to other neurotransmitters found in the brain. Recently, it has also been found that serotonin is involved in Alzheimer's disease either directly or indirectly by its actions on serotonergic neurons. To understand and treat the diseases caused by abnormalities in the serotonergic system in the brain, it is certain that its mechanism of function has to be well investigated. So far several 5-HT receptors and receptor subtypes have been well characterized. Moreover, serotonin agonists and antagonists acting on specific receptors are chemically synthesized and are now available for the prevention or treatment of serotonergic related diseases. In recent years, a great demand for developing ...

2004-07-01

411

British Library Electronic Table of Contents (United Kingdom)

Trastuzumab increases survival amongst women with human epidermal growth factor receptor (HER)-2 receptor positive metastatic breast cancer, but maternal and fetal risks are associated with advanced disease and its treatment in pregnancy. We present a case of a primigravid with HER-2 positive metastatic breast cancer who received trastuzumab throughout pregnancy. She presented with cerebral metastases, requiring surgical decompression and resection. Reversible oligohydramnios developed during pregnancy. Fetal safety data on trastuzumab in pregnancy is limited, but case reports suggest a recurring pattern of (mostly reversible) oligohydramnios.

2011-01-01

412

[New cardiotonic agents].

Localisation of the neuropeptide PACAP and its receptors in the rat parathyroid and thyroid glands.

The possibilities for therapy in the field of severe cardiac insufficiency have been extended in recent years by the introduction of novel agents endowed with a positive inotropic action. These substances may be arranged in two large classes: sympathomimetic agents and "non sympathomimetic--non digitalis-like" inotropic agents. The stimulant action of noradrenaline, adrenaline and isoproterenol on beta-adrenergic myocardial receptors has been clearly demonstrated but the usefulness of these medicines is limited by their positive chronotropic and arrhythmogenic actions. Dopamine and dobutamine have proved to be very useful in the treatment of patients in intensive care units. However, the exclusively intravenous route of administration limits their importance to the medium or long term. Several compounds, which are active by the oral route, have been the subject of therapeutic trials for the short or medium term. The problems posed by their use result, in the first ...

1985-12-01

413

Cloning of the cDNA for the human. beta. /sub 1/-adrenergic receptor

PACAP (pituitary adenylate cyclase activating polypeptide) is widely distributed neuropeptide acting via three subtypes of receptors, PAC(1), VPAC(1) and VPAC(2). Here we examined the localisation and nature of PACAP-immunoreactive nerves in the rat thyroid and parathyroid glands and defined the distribution of PAC(1), VPAC(1) and VPAC(2) receptor mRNA's. In the parathyroid gland a large number of nerve fibres displaying PACAP-immunoreactivity were distributed beneath the capsule, around blood vessels and close to glandular cells. Most of the PACAP-nerves were sensory, since they co-stored CGRP (calcitonin-gene-related peptide) and were sensitive to capsaicin-treatment. mRNA's for PAC(1) and VPAC(2) receptors occurred in the parathyroid gland, mainly located in the glandular cells. In the thyroid gland PACAP-immunoreactive nerve fibres were associated with blood vessels, thyroid follicles and parafollicular C-cells. A high ...

2010-12-19

414

Developments of PET radioligands for NMDA receptors

Screening of a human placenta lambdagt11 library has led to the isolation of the cDNA for the human ..beta../sub 1/-adrenergic receptor (..beta../sub 1/AR). Used as the probe was the human genomic clone termed G-21. This clone, which contains an intronless gene for a putative receptor, was previously isolated by virtue of its cross hybridization with the human ..beta../sub 2/-adrenergic receptor (..beta../sub 2/AR). The 2.4-kilobase cDNA for the human ..beta../sub 1/AR encodes a protein of 477 amino acid residues that is 69% homologous with the avian ..beta..AR but only 54% homologous with the human ..beta../sub 2/AR. This suggests that the avian gene encoding ..beta..AR and the human gene encoding ..beta../sub 1/AR evolved from a common ancestral gene. RNA blot analysis indicates a message of 2.5 kilobases in rat tissues, with a pattern of tissue distribution consistent with ..beta../sub 1/AR binding. This pattern is quite ...

1987-11-01

415

Status of safety at Areva group facilities. 2007 annual report; Areva, etat de surete des installations nucleaires. Rapport annuel 2007

Aim: There has been a great demand for developments of the radioligands to visualize the N-methyl-D-aspartate (NMDA) receptors by PET/SPECT. We have recently synthesized two C-11 labeled antagonists for the glycine-binding site on NMDA receptors. The aim of this work is to examine for their in vitro and in vivo binding characteristics, and to evaluate their potentials as PET radioligands for the NMDA receptors. Materials and methods: Two C-11 labeled 4-hydroxy-2-quinolones (1 and 2) were synthesized by conventional methylation of the corresponding phenols with ["1"1C]methyl iodide. In vitro and ex vivo quantitative autoradiographs with imaging plate, as well as animal PET, were employed in order to evaluate their in vitro and in vivo binding to the NMDA receptors. Results: The compound 1 showed the specific binding to rat brain slices with higher localization in the hippocampus and cerebral cortex than ...

2002-09-01

416

Status of nonsilicon photovoltaic solar cell research

This report describes the status of nuclear safety and radiation protection in the facilities of the AREVA group and gives information on radiation protection in the service operations, as observed through the inspection programs and analyses carried out by the General Inspectorate in 2007. Having been submitted to the group's Supervisory Board, this report is sent to the bodies representing the personnel. Content: 1 - A look back at 2007 by the AREVA General Inspector: Visible progress in 2007, Implementation of the Nuclear Safety Charter, Notable events; 2 - Status of nuclear safety and radiation protection in the nuclear facilities and service operations: Personnel radiation protection, Event tracking, Service operations, Criticality control, Radioactive waste and effluent management; 3 - Performance improvement actions; 4 - Description of the General Inspectorate; 5 - Glossary.

2007-07-01

417

Status of electric power in the Missouri River Basin

The current status of non-silicon photovoltaic solar cells is discussed including the identification of current technical and economic issues and future research directions for potential high efficiency low cost technologies. This review covers such advanced materials as CdS/Cu/sub 2/S, CdS/CuInSe/sub 2/, and GaAs homojunction and heterojunction devices; such emerging materials as InP, Zn/sub 3/P/sub 2/ and CdTe; and liquid junction electrochemical photovoltaic cells. An attempt is made to compare the current relative status of these various technologies and to indicate their near term potential where possible. 105 refs.

1980-01-01

418

Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain

This third Missouri River Basin Commission report on Status of Electric Power in the Missouri River Basin provides information on the status of electric power generation, future needs, and potentials for meeting these needs. Information for this 1980 update is based upon available published information up to and including December 31, 1979. State and federal members of the Missouri River Basin Commission provided information for sections of the report and on legislative activities. Information is included on the planning and projected costs of hydro, nuclear and fossil-fuel power plants, pumped-storage plants, transmission systems, projected power demands, the environmental, socio-economic-cultural impacts of electric power generation, and regulations affecting energy development. (LCL)

1980-01-01

419

British Library Electronic Table of Contents (United Kingdom)

Summary Status epilepticus or other brain-damaging insults launch a cascade of events that may lead to the development of epilepsy. MRI techniques available today, including T2- and T1-weighted imaging, functional MRI, manganese enhanced MRI (MEMRI), arterial spin labeling (ASL), diffusion tensor imaging (DTI), and phase imaging, can detect not only damage caused by status epilepticus but also plastic changes in the brain that occur in response to damage. Optimal balance between damage and recovery processes is a key for planning possible treatments, and noninvasive imaging has the potential to greatly facilitate this process and to make personalized treatment plans possible.

2011-01-01

420

Green tea consumption, abdominal obesity as related factors of lacunar infarction in Korean women

British Library Electronic Table of Contents (United Kingdom)

Objectives Our purpose was to evaluate interaction of green tea consumption and abdominal obesity as related factors for lacunar infarction in Korean women. Designs A hospital-based, incident case-control study. Settings The Prevention and Managements of Stroke in Women study. Participants Cases (n=233) of first incident lacunar infarction were enrolled and matched by age to stroke-free hospital controls (n=204). Measurements The data were collected through face-to-face interviews by well trained research assistants to assess demographic, medical, lifestyle, marital status, religions status, green tea consumptions, family history of stroke, smoking status, alcohol consumption, meat and vegetable intake frequency, and past history of hypertension. Biochemical analysis, fasting blood specime...

2011-01-01

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421

Digitization of past question papers, dissertations and theses: A case study of 30 Nigerian university libraries

British Library Electronic Table of Contents (United Kingdom)

SummaryThis paper evaluates the status of digitization in 30 Nigerian university libraries with a view to identifying the status, progress, prospects and challenges to digitize library materials and form the basis of providing a roadmap to successful execution of digitization projects. The study assessed the status of digitization of past question papers, theses and dissertations in Nigerian university libraries from May to September 2006 through a self-administered questionnaire, site visits and interviews. It was found that, though there are automation services in those universities, there is no digitization of these materials mentioned in the surveyed institutions. The major obstacles militating against digitizing in the university libraries include lack of funds, lack of appropriate fa...

2007-01-01

422

Assessing vineyard water status using the reflectance based Water Index

British Library Electronic Table of Contents (United Kingdom)

In the Mediterranean arc, vines for wine production are mainly grown without the support of irrigation. Under such conditions, site variables affecting the extent and seasonal timing of water deficits are the dominant environmental constraints for grape production. Moreover, water availability and vine water status are the factors most comprehensively determining fruit composition and, thus, wine quality. Therefore, monitoring the extent of water stress in vines might be a valuable tool for the optimisation of grape yield and quality. The objective of this study was to evaluate the feasibility of using the reflectance based Water Index (WI) to estimate vine water status at the leaf and canopy levels. The study was conducted on Vitis vinifera cv. Chardonnay potted plants submitted to contra...

2010-01-01

423

Tokamak and laboratory modeling of hydrocarbon film deposition on metallic mirrors

The mouse formin (Fmn) gene: Genomic structure, novel exons, and genetic mapping

In this work, amorphous hydrocarbon (a-C:H) film deposition on metallic mirrors was studied during working shots in tokamak T-10 and at exposure in Ar/CHD3/D2 dc magnetron discharge in a special laboratory high vacuum setup. Analysis of film composition (including hydrogen content) was carried out using nuclear physical methods. Thickness and optical parameters (refractive and extinction coefficients) of the films were estimated by ellipsometry. Laboratory films can be characterized as soft a-C:H films in comparison with hard tokamak films (? = 1.2 and 1.8 g/cm3, respectively). For the first one, a linear dependence of deposition rate on mirror temperature was observed in a wide temperature range. The addition of methane into initial Ar/D2 magnetron gas mixture leads to an increase of deposition rate. The data obtained should be taken into account to prevent hydrocarbon film formation on the surface of ...

2009-06-15

424

Stabilization and limit theorems for geometric functionals of Gibbs point processes

Mutations in the mouse formin (Fmn) gene, formerly known as the limb deformity (ld) gene, give rise to recessively inherited limb deformities and renal malformations or aplasia. The Fmn gene encodes many differentially processed transcripts that are expressed in both adult and embryonic tissues. To study the genomic organization of the Fmn locus, we have used Fmn probes to isolate and characterize genomic clones spanning 500 kb. Our analysis of these clones shows that the Fmn gene is composed of at least 24 exons and spans 400 kb. We have identified two novel exons that are expressed in the developing embryonic limb bud as well as adult tissues such as brain and kidney. We have also used a microsatellite polymorphism from within the Fmn gene to map it genetically to a 2.2-cM interval between D2Mit58 and D2Mit103. 36 refs., 6 figs., 1 tab.

1997-02-01

425

Natural convection cooling of a cold neutron source with vaporizing deuterium at temperatures of 25 k

Given a Gibbs point process $\\P^{\\Psi}$ on $\\R^d$ having a weak enough potential $\\Psi$, we consider the random measures $\\mu_\\la := \\sum_{x \\in \\P^{\\Psi} \\cap Q_\\la} \\xi(x, \\P^{\\Psi} \\cap Q_\\la) \\delta_{x/\\la^{1/d}}$, where $Q_{\\la} := [-\\la^{1/d}/2,\\la^{1/d}/2]^d$ is the volume $\\la$ cube and where $\\xi(\\cdot,\\cdot)$ is a translation invariant stabilizing functional. Subject to $\\Psi$ satisfying a localization property and translation invariance, we establish weak laws of large numbers for $\\la^{-1} \\mu_\\la(f)$, $f$ a bounded test function on $\\R^d$, and weak convergence of $\\la^{-1/2} \\mu_\\la(f),$ suitably centered, to a Gaussian field acting on bounded test functions. The result yields limit laws for geometric functionals on Gibbs point processes including the Strauss and area interaction point processes as well as more general point processes defined by the ...

2008-01-01

426

Evaluation of small-angle neutron scattering curves of unilamellar phosphatidylcholine liposomes using a multi shell model of bilayer neutron scattering length density

In the High Flux Reactor (HFR) at Grenoble a new horizontally arranged cold neutron source will be installed that uses liquid deuterium (D_2) as the moderator for cold neutrons. This cold source should provide a high neutron flux, it should be simple in design, and be characterized by high reliability and by safe operation. A high neutron flux calls for installation of the cold source near the HFR core and good moderation requires a D_2 volume of #DELTA#5 litres. Hence, the moderator, contained in a horizontally arranged cylindrical cell of 21 cm diameter and 20 cm length, is installed at the end nearest to the core of a horizontal beam tube of roughly 4.5 m length with an inner diameter of only 23 cm (Fig. 1). The HFR will be equipped with a second cold neutron source. The installation in the existing horizontal beam tube together with the amount of heat released determined the problems to be solved: ...

427

Electron momentum spectroscopy of H_2 and D_2: Ionization to ground and excited final states

Computer simulated small-angle neutron scattering curves of spherical poly disperse extruded unilamellar liposomes from saturated 1,2-diacylphosphatidylcholines in the aqueous phase are evaluated by using a multi shell model, which divides the lipid bilayer of liposomes into the polar head group region, and the nonpolar hydrocarbon region consisting of the chains of methylene groups and of the region of methyl groups. In the each of these regions, the coherent neutron scattering length density is supposed to by homogeneous. The evaluation is based on obtaining of radius of gyration from Kratky-Porod plot of small-angle neutron scattering data in the Guinier region of small scattering vector values. From radii of gyration obtained at several different molar fractions N_D_2_O/(N_D-2_O + N_H_2_O) in the aqueous phase (contrasts) and independent volumetric data, the lipid surface area A_L (or the bilayer ...

2000-12-15

428

Development of a best estimate auditing code for CANDU thermal hydraulic safety analysis

The symmetric noncoplanar (e,2e) cross sections (momentum profiles) of H_2 and D_2 for the transitions to the 2p#sigma#_u and 2s#sigma#_g excited ion states have been measured, relative to the ground-state ion transition, using a high-sensitivity multichannel momentum-dispersive electron momentum spectrometer (EMS) at an impact energy of 1200 eV. Newly calculated plane-wave impulse approximation (PWIA) cross sections, based on a full-configuration-interaction H_2 wave function, are compared to the experimental results. These calculations are in better agreement with the experimental results for the transition to the 2s#sigma#_g ion state than the earlier theoretical work of Liu and Smith, Jr. [Phys. Rev. A 31, 3003 (1985)] which has been found to be in error. Nevertheless, significant discrepancies between the relative experimental and theoretical cross sections are observed for the transitions to excited ion states, suggesting a failure of the ...

429

Cross sections for electron scattering by atomic potassium

The main purpose of this study is to develop a thermal hydraulic auditing code for the CANDU reactor, modifying the model of existing PWR auditing tool , i.e. RELAP5/MOD3. This scope of project is a fourth step of the whole project, applying the RELAP5/MOD3/CANDU+ version for the real CANDU plant LOCA Analysis and D2O leakage incident. There are three main models under investigation, i.e. Moody critical flow model, flow regime model of horizontal CANDU bundle, and fuel element heatup model when the stratification occurs, especially when CANDU LOCA is tested. Also, for Wolsung unit 1 D2O leakage incident analysis, the plant behavior is predicted with the newly developed version for the first 1000 seconds after onset of the incident, with the main interest aiming for system pressure, level control system, and thermal hydraulic transient behavior of the secondary system. The model applied for this ...

2001-03-01

430

Alpha particle spectroscopic strengths for levels populated in the "2"0 "2"1 "2"2Ne("6Li, d)"2"4 "2"5 "2"6Mg reactions

Electron elastic and collisional excitation cross sections from the ground state of potassium are calculated using the noniterative integral-equation method of Henry, Rountree, and Smith [Comput. Phys. Commun. 23, 233 (1981)] in the electron energy range 4#<=#E#<=#200 eV. Configuration-interaction target wave functions that take account of correlation and polarization effects are used to represent the ground state and the six lowest excited states 4p "2P degree, 5s "2S, 3d "2D, 5p "2P degree, 4d "2D, and 6s "2S. Elastic and discrete excitation cross sections are obtained in a seven-state close-coupling (7CC) approximation. The 7CC elastic and excitation cross sections are compared and contrasted. Near threshold the elastic cross section dominates the resonance, 4s "2S#->#4p "2P degree, and the sum of the other remaining excitation cross sections. Comparison of our total cross sections with some ...

431

cap alpha. -2 adrenergic receptor: a radiohistochemical study

The "2"0 "2"1 "2"2Ne("6Li, d)"2"4 "2"5 "2"6Mg reactions have been studied at a bombarding energy of 32 MeV. Alpha particle spectroscopic strengths have been extracted for several low-lying levels by a finite-range distorted wave analysis. These are compared with theoretical predictions. The agreement is good both for relative strengths to different levels within a nucleus and for ground-state strengths relative to the "1"6O("6Li, d) result. Strengths calculated using eigenfunctions determined in large shell-model computations agree well with pure symmetry SU(3) predictions. The "2"1Ne("6Li, d) angular distributions for transitions to the ground-state band of "2"5Mg are characterized by the lower of the two L-transfers allowed for populating each level. For the 3"+(5.24 MeV) unnatural parity level in "2"4Mg, a two-step calculation gives a better account of the data than does a compound nuclear calculation. (Auth.).

432

A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activity

..cap alpha..-2 adrenergic agents have been shown to influence blood pressure, heart rate and other physiological and behavioral functions through interactions with adrenergic pathways within the central nervous system. Pharmacologically relevant ..cap alpha..-1 adrenergic receptors were biochemically characterized and radiohistochemically analyzed in intact tissue sections of the rat and human central nervous system. The anatomical distribution of the ..cap alpha..-2 receptors, labeled with the agonist (/sup 3/H)para-aminoclonidine, verified the concept that ..cap alpha..-2 receptors are closely associated with adrenergic nerve terminals and that ..cap alpha..-2 agents can influence autonomic and endocrine function through an action in the central nervous system. Since ..cap alpha..-2 agonists can influence sympathetic outflow, ..cap alpha..-2 binding sites were closely analyzed in the intermediolateral cell column of the ...

1984-01-01

433

The natural convection cooling with vaporizing deuterium for the horizontally arranged cold neutron source of the HFR - Grenoble

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has two major functions: interacting with the receptor to mediate virus entry and inducing protective immunity. Coincidently, the receptor-binding domain (RBD, residues 318-510) of SAR-CoV S protein is a major antigenic site to induce neutralizing antibodies. Here, we used RBD-Fc, a fusion protein containing the RBD and human IgG1 Fc, as a model in the studies and found that a single amino acid substitution in the RBD (R441A) could abolish the immunogenicity of RBD to induce neutralizing antibodies in immunized mice and rabbits. With a panel of anti-RBD mAbs as probes, we observed that R441A substitution was able to disrupt the majority of neutralizing epitopes in the RBD, suggesting that this residue is critical for the antigenic structure responsible for inducing protective immune responses. We also demonstrated that the RBD-Fc bearing R441A mutation could not ...

2006-05-26

434

Spectra of positrons and electrons emitted in "8"8Y decay

Natural convection of vaporizing Deuterium at 25 K transports the heat generated in the moderator cell of the cold neutron source to a He cooled condenser. The thermohydraulics of this thermosiphon were precalculated and the results verified by experiments in a 1:1 model using D_2 as fluid. The experimental results show that the thermosiphon operates stable. The demanded liquid content of the cell as well as wall temperatures below 50 K can be ensured by a proper design of the cell outlet flow geometry. A 7 min. loss of cryogenic power results in transient temperatures of the cell wall of not more than 300 K.

1991-08-01

435

Reports of the second All-Union conference on the chemistry of transplutonium elements (Dmitrovgrad, June 21-23, 1963)

The "8"8Y decay has been studied with the aim to discover emission of monohromatic positrons (MP). The "8"8Sr(d,2N) reaction was used for production of "8"8Y (#beta#"+, Tsub(1/2)=106.6 days) nuclides. The prismatic beta spectrometer has been used to measure spectra of electrons and positrons. No MPs have been found. The resulting upper bound for their emission rate turned out to be lower than theoretically expected one.

436

Purification of cyclotron-produced {sup 203}Pb for labeling Herceptin

The nine papers presented at this conference cover the following topics: the systematization, condensed description, and prediction of sets of anion exchange extraction constants on the basis of their statistical computer treatment; characteristics and uses of solid extractants containing D2EHPA and TBP for separating the transplutonium elements; enrichment of americium 242m and americium 242 by the Szilard-Chalmers method; an x-ray diffraction pattern analysis for transplutonium compounds; the radiation chemistry of americium; and the effects of alpha irradiation on the behavior of americium in perchlorate solutions.

1987-05-01

437

Perturbing the ground ring of 2D string theory

A simple and rapid procedure was developed for the purification of cyclotron-produced {sup 203}Pb via the {sup 203}Tl(d,2n) {sup 203}Pb reaction. A Pb(II) selective ion-exchange resin, with commercial name Pb Resin from Eichrom Technologies, Inc., was used to purify {sup 203}Pb from the cyclotron-irradiated Tl target with excellent recovery of the enriched Tl target material. The purified {sup 203}Pb was used to radiolabel the monoclonal antibody Herceptin. The in vitro and in vivo properties of the {sup 203}Pb radioimmunoconjugate were evaluated.

2005-04-01

438

Chemical aspects of light and heavy water nuclear power reactors : fission product release and fuel performance

In this paper, the authors use free field techniques in D = 2 string theory t calculate the perturbation of the special state algebras when the cosmological constant is turned on. In particular, the authors find that the 'ground cone' preserved by the ring structure is promoted to a three-dimensional hyperboloid as conjectured by Witten. On the other hand, the perturbed (1,1) current algebra of moduli deformations is computed completely, and no simple geometrical interpretation is found. The authors also quote some facts concerning the Liouville matrix a model dictionary in this class of theories.

1992-12-10

439

A combinatorial spanning tree model for knot Floer homology

Problem areas in BWRs, PWRs and PHWRs, from the viewpoint of chemistry, and the problem of fission product release in nuclear reactors are discussed. These problem areas are : fuel performance, off-normal water chemistry due to condenser leaks, the transport and deposition of the activated corrosion and fission products, denting in steam generators (in the case of PWRs), ingress of air in the cover gas helium and consequent radiolysis of D_2O in the moderator circuit (in the case of PHWRs). (M.G.B.).

1981-05-01

440

An overview of AECL's participation in the Korean Wolsung Tritium Removal Facility Project (WTRF)

We iterate Manolescu's unoriented skein exact triangle in knot Floer homology with coefficients in the fraction field of the group ring (Z/2Z)[Z]. The result is a spectral sequence which converges to a stabilized version of delta-graded knot Floer homology. The (E_2,d_2) page of this spectral sequence is an algorithmically computable chain complex expressed in terms of spanning trees, and we show that there are no higher differentials. This gives the first combinatorial spanning tree model for knot Floer homology.

2011-01-01

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441

Wolsong 2, 3 and 4 quarterly progress review report on NSSS engineering and design.

Full text: In heavy-water-moderated power reactors, tritium is primarily produced by neutron capture in deuterium nuclei in the moderator and coolant. For CANDU 6 reactors, the estimated steady-state values are #approx# 3 TBq#centre dot#kg"-"1 D_2O in the moderator and #approx# 74 GBq#centre dot#kg"-"1 D_2O in the coolant. Tritium removal is one option available to reactor operators for use in their heavy water and tritium management strategies. The WTRF is designed to remove tritium from tritiated heavy water in each of the four CANDU units at the Wolsung Site, to immobilize the tritium and to store it on site. The detritiation process is based on three steps: the first one (front-end) involves the transfer of tritium from heavy water to deuterium gas; the second one (enrichment) concentrates the tritium in a cryogenic distillation system to produce essentially pure ...

2007-11-07

442

UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications

This is the quarterly progress review report for Wolsung NPP 2, 3, 4 NSSS design and engineering which evaluates the performance of project and describes the project highlight, manpower loading status, design and engineering and project related meeting by...

1996-01-01

443

The physical and mental health of a large military cohort: baseline functional health status of the Millennium Cohort

Cytosine methylation in DNA is a major epigenetic signal, and plays a central role in propagating chromatin status during cell division. However the mechanistic links between DNA methylation...Full Text Available

2009-01-01

444

The impact of water intake on energy intake and weight status: a systematic review

Background:The US military is currently involved in large, lengthy, and complex combat operations around the world. Effective military operations require optimal health of deployed...Full Text Available

445

The concept of mental disorder: diagnostic implications of the harmful dysfunction analysis

The effects of consuming water with meals rather than drinking no beverage or various other beverages remains under-studied. This systematic review of English language studies compared the effects...Full Text Available

2010-09-01

446

The associations between serum sex hormones, erectile function, and sex drive

What do we mean when we say that a mental condition is a medical disorder rather than a normal form of human suffering or a problem in living? The status of psychiatry as a medical discipline depends...Full Text Available

2007-10-01

447

The Role of Thyroid Hormone in Testicular Development and Function

Few studies have examined the association between sex hormone serum levels, erectile function, and sex drive. Using data from the Olmsted County Study of Urinary Symptoms and Health Status among...Full Text Available

2008-09-01

448

The QCD coupling and parton distributions at high precision

Thyroid hormone is a critical regulator of growth, development and metabolism in virtually all tissues, and altered thyroid status affects many organs and systems. Although for many years testis...Full Text Available

2008-12-01

449

The Effects of Aspirin-Like Drugs on the Nutritional Status of Pregnant Rats and Offspring

A survey is given on the present status of the nucleon parton distributions and related precision calculations and precision measurements of the strong coupling constant {alpha}{sub s}(M{sup 2}{sub Z}). We also discuss the impact of these quantities on precision observables at hadron colliders. (orig.)

2010-07-15

450

The Comprehensive Dialysis Study (CDS): A USRDS Special Study

Previous studies have shown that salicylates and protein-calorie malnutrition independently compromise maturation and growth of infants. In the present study, pregnant rats were fed normal-and low-protein...Full Text Available

1988-05-01

451

Temporal trends in reproductive performance in Irish dairy herds and associated risk factors

Background and objectives: The Comprehensive Dialysis Study (CDS) aimed to understand factors contributing to physical, functional, and nutritional health status among patients starting dialysis.Design,...Full Text Available

2009-03-01

452

Status of the Lawrence Berkeley Laboratory and Lawrence Livermore National Laboratory free electron laser (FEL)

Irish dairy herd fertility has been declining since the 1980s. The extent, nature and causes of this decline in fertility and the current status of Irish dairy herd fertility were described....Full Text Available

453

Status of rheumatic heart disease in rural Pakistan

A description of the FEL experiment underway at the 10 kA, 5 MeV Experimental Test Accelerator (ETA) is described. The facility has been designed to investigate the high-gain operation of an FEL.

1983-09-19

454

Spawning seasons of Rasbora tawarensis (Pisces: Cyprinidae) in Lake Laut Tawar, Aceh Province, Indonesia

Objectives: To determine the community based prevalence of rheumatic heart disease (RHD) in the rural population of the district of Rahim Yaar Khan in Pakistan.Subjects...Full Text Available

2004-04-01

455

Sociodemographic factors in a pediatric chronic pain clinic: The roles of age, sex and minority status in pain and health characteristics

BackgroundRasbora tawarensis is an endemic freshwater fish in Lake Laut Tawar, Aceh Province, Indonesia. Unfortunately, its status is regarded as critical endangered...Full Text Available

456

Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors

Little is known about how sociodemographic factors relate to children’s chronic pain. This paper describes the pain, health, and sociodemographic characteristics of a cohort of children...Full Text Available

2010-07-01

457

Seizures increase cell proliferation in the dentate gyrus by shortening progenitor cell cycle length

BackgroundCurrently used indicators of iron status have limitations. Hepcidin, a key regulator of iron metabolism, is reduced in iron deficiency. We sought to determine the properties...Full Text Available

2011-08-01

458

SN1987A: The supernova of a lifetime

PurposeA prolonged seizure, status epileptics (SE), is a potent stimulus for increased neurogenesis in the dentate gyrus of the hippocampus. Molecular mechanisms...Full Text Available

2009-11-18

459

Report to Congress on Control of Combined Sewer Overflow in the United States.

The current status of cosmological observations is presented; and the light curves and radiation spectra from supernova SN1987A are used in comparison between expected and observed universal nucleosynthesis and star evolution data./aip/.

1988-09-20

460

Recommissioning and first operation of the CWDD injector at Argonne National Laboratory

This report presents by state the status of awarded grants, requested grants, and the estimated time required to achieve required control of combined sewer overflow pollution. It also compares discharges of pollutants from treated municipal effluent with ...

1978-01-01

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461

Quantum computing for physics research

The CWDD injector has been shipped to Argonne National Laboratory, installed, and recommissioned. Commissioning progress, operational status, and future plans are reported. Operational experience at ANL is compared with that obtained at Culham.

1992-12-31

462

Quality measurement and control in physician decision making: state of the art.

Quantum computers hold great promises for the future of computation. In this paper, this new kind of computing device is presented, together with a short survey of the status of research in this field. The principal algorithms are introduced, with an emphasis on the applications of quantum computing to physics. Experimental implementations are also briefly discussed.

2006-04-01

463

Principle of pulse frequency measurement and methods for improving frequency meters accuracy

The status of the concept of controlling the quality of physicians is reviewed as are studies that have been done on methods to measure and improve quality. The conclusions are dismal given the rhetoric...Full Text Available

1982-01-01

464

Principle of pulse frequency measurement and methods for improving frequency meters accuracy

Specificity of the pulses mean frequency measurement (the pulses being generated in a stochastic process) is described. Status of the domain of analog frequency meters is presented. Methods of increasing accuracy of such meters are discussed.

1980-01-01

465

Pregravid BMI is associated with dietary restraint and psychosocial factors during pregnancy1

Specificity of the pulses mean frequency measurement (the pulses being generated in a stochastic process) is described. Status of the domain of analog frequency meters is presented. Methods of increasing accuracy of such meters are discussed. (author).

1980-01-01

466

Predictors of healthcare professionals' intention and behaviour to encourage physical activity in patients with cardiovascular risk factors

The objective was to investigate the association of pregravid weight status, dietary restraint and psychosocial factors during pregnancy. We used data from the Pregnancy, Infection and Nutrition...Full Text Available

2009-03-01

467

Precision tests of the electroweak interaction

BackgroundHealthcare professionals can play a crucial role in optimizing the health status of patients with cardiovascular risk factors (abdominal obesity, high blood pressure, low...Full Text Available

468

Population morbidity screening--practical methodology for small populations.

The status of the electroweak Standard Model is reviewed in the light of recent precision data and new theoretical results which have contributed to improve the predictions for precision observables, together with the remaining inherent theoretical uncertainties. Consequences for possible new physics are also discussed.

1995-01-01

469

Outcome of patients with systemic rheumatic disease admitted to medical intensive care units.

During a study of the health status of children in rural Nigerian communities a gross lack of fit was observed between the sample and the growth attainment standards derived from local longitudinal...Full Text Available

1984-07-01

470

Opioids and the Treatment of Chronic Pain: Controversies, Current Status, and Future Directions

The outcome of patients admitted to intensive care units is known to be influenced by such factors as age, previous health status, severity of disease, and diagnosis. To estimate the outcome of such...Full Text Available

1992-05-01

471

Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis

Opioids have been regarded for millennia as among the most effective drugs for the treatment of pain. Their use in the management of acute severe pain and chronic pain related to advanced medical...Full Text Available

2008-10-01

472

Mental health of female foreign spouses in transnational marriages in southern Taiwan

BackgroundIncreasing evidence demonstrates that stem cells maintain their identities by a unique transcription network and chromatin structure. Opposing epigenetic modifications...Full Text Available

2010-01-01

473

Longitudinal Evaluation of Sexual Function in a Male Cohort: The Olmsted County Study of Urinary Symptoms and Health Status among Men

BackgroundThe aim of this study was to investigate the mental health status, and the risk factors associated with mild psychiatric disorders, of female foreign spouses (from Vietnam,...Full Text Available

474

Genome size and wing parameters in passerine birds

IntroductionThe presence of erectile or ejaculatory dysfunction may indicate physical problems; however, individual perceptions (e.g., sexual satisfaction) may reflect...Full Text Available

2009-09-01

475

Despite their status as the most speciose group of terrestrial vertebrates, birds exhibit the smallest and least variable genome sizes among tetrapods. It has been suggested that this is because powered...Full Text Available

2009-01-07

476

Free electron laser

Flexible bronchoscopic management of benign tracheal stenosis: long term follow-up of 115 patients

Physics and technology of free electron laser (FEL) are reviewed. Mechanisms of stimulated emission in FEL and its present status and future prospects are presented. Electromagnetic wiggler, two stage FEL and so on are also interpreted. Finally, accelerators and wigglers for FEL, recent FEL experiments and FEL applications are noted. (author).

477

BackgroundManagement of benign tracheal stenosis (BTS) varies with the type and extent of the disease and influenced by the patient's age and general health status, hence we sought...Full Text Available

478

Fermion Determinants

Farm-level risk factors for the presence of Salmonella in 89 Alberta swine-finishing barns

The current status of bounds on and limits of fermion determinants in two, three and four dimensions in QED and QCD is reviewed. A new lower bound on the two-dimensional QED determinant is derived. An outline of the demonstration of the continuity of this determinant at zero mass when the background magnetic field flux is zero is also given.

2002-01-01

479

Efficacy and cost-effectiveness of nutritional intervention in elderly after hip fracture: design of a randomized controlled trial

This study investigated potential risk factors for the presence of Salmonella on 89 Alberta swine-finishing farms with the use of a questionnaire. Salmonella status...Full Text Available

2007-10-01

480

Effects of Mitigative Measures on Productivity of White Sturgeon Populations in the Columbia River Downstream from McNary Dam, and Status and Habitat Requirements of White Sturgeon Populations in the Columbia and Snake Rivers Upstream from McNary Dam, 1993-1994 Annual Report.

BackgroundHip fracture patients often have an impaired nutritional status at the time of fracture, which can result in a higher complication rate, prolonged rehabilitation time and...Full Text Available

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481

Effect of Leucovorin (Folinic Acid) on the Developmental Quotient of Children with Down's Syndrome (Trisomy 21) and Influence of Thyroid Status

No abstract prepared.

1995-05-01

482

Divorce, divorce rates, and professional care seeking for mental health problems in Europe: a cross-sectional population-based study

BackgroundSeven genes involved in folate metabolism are located on chromosome 21. Previous studies have shown that folate deficiency may contribute to mental retardation in Down's...Full Text Available

483

Differential expression of Haemophilus parasuis genes in response to iron restriction and cerebrospinal fluid

BackgroundLittle is known about differences in professional care seeking based on marital status. The few existing studies show more professional care seeking among the divorced...Full Text Available

484

Development and Validation of the Convalescence And Recovery Evaluation (CARE) for Measuring Quality of Life after Surgery

Haemophilus parasuis is an important opportunistic pathogen in swine of high health status, but to date no proven virulence factors have been described. As virulence factors are known...Full Text Available

2007-07-01

485

Detection of TP53 mutation, loss of heterozygosity and DNA content in fine-needle aspirates of breast carcinoma.

PurposeTo develop a generic instrument for measuring short-term health status in the recovery period among patients undergoing abdominal and pelvic surgery.Full Text Available

2008-08-01

486

Current status of therapy for breast cancer worldwide and in Japan

Recent preclinical and clinical data suggest that TP53 status and TP53 mutations may be important in determining tumour aggressiveness and therapy response. In this study we investigate the feasibility...Full Text Available

1998-01-01

487

Consequences of Low Neonatal Iron Status due to Maternal Diabetes Mellitus on Explicit Memory Performance in Childhood

The results of clinical trials conducted in Europe and North America have been incorporated into treatment strategies for breast cancer in Japan. Despite the use of similar treatment regimens, why has...Full Text Available

2011-02-10

488

Comprehensive Analysis of Blood Culture Performed at Nine University Hospitals in Korea

Diabetic pregnancies are characterized by chronic metabolic insults, including iron deficiency, that place the developing brain at risk and for memory impairment later in life. A behavioral...Full Text Available

2009-11-01

489

Coal Liquefaction Program: Fiscal year 1989, Summary program plan

BackgroundOptimal blood culture performance is critical for successful diagnosis and treatment of sepsis. To understand the status of blood culture, we investigated several aspects...Full Text Available

2011-04-01

490

Changes in inflammatory mediators in experimental periodontitis in the rhesus monkey.

Program plans of the Office of Coal Technology in coal liquefaction are presented. Technology description, status, market applications, program strategy and program management descriptions are included. 2 figs. (CBS)

1989-01-01

491

Change in HER-2/neu Status from Negative to Positive following Treatment in Breast Cancer: A Case Report

Ligature-induced periodontitis was monitored for 6 months in eight Macaca mulatta monkeys to examine clinical status, radiographic bone level, and crevicular fluid (CF) levels of prostaglandin E2 (PGE2),...Full Text Available

1993-04-01

492

Cargo Projects Milestones, Schedules and Status Summary

IntroductionApproximately 25–30% of breast cancers are assumed to be HER-2/neu positive. It is well known that HER-2/neu-positive cancers after treatment with trastuzumab...Full Text Available

493

CDC - Annual Report to the Nation on the Status of Cancer, 1975...

subject to a learning curve which should help to lessen the user's time at KSC. An MMSE Payload Handling Fixture has ...... (F4.I ASSlUN IASILlM.ny.CTC I ...

494

tumors make up two-thirds of all adult brain tumors and one-third of childhood brain tumors. Cancer Among Men, 2003-2007 Incidence rates decreased for lung, colorectal,...

2011-10-15

495

Be stars

Associations between the clinical signs of chronic endometritis with ovarian cysts and body condition loss in German Holstein Friesian cows

Research on Be stars from the early work of Merrill and Struve to the present is reviewed, including recent observations from space. A number of models which have been proposed to explain the Be phenomenon are discussed, and the evolutionary status of Be stars is considered. 126 references.

1988-07-01

496

Anaerobic Nitrate Respiration by Erwinia carotovora subsp. atroseptica during Potato Tuber Invasion

The objective of this retrospective field study was to associate the type and smell of discharge, the size of the uterus, the ovarian and treatment status, and the time to diagnosis of animals with...Full Text Available

2009-12-01

497

Accelerator technology program, January-June 1982. Status report

The in planta induction of anaerobic nitrate respiration by Erwinia carotovora subsp. atroseptica in relation to the in situ oxygen status in soft rotting potato tubers...Full Text Available

1993-11-01

498

A Position Paper on the Electronic Publication of Nematode Taxonomic Manuscripts

The major projects of the Los Alamos National Laboratory's Accelerator Technology Division are discussed, covering activities that occurred during the first six months of calendar 1982.

1983-12-01

499

"Toward an International Materials Research Network" Status Report

Several nematode species have now attained ‘model organism’ status, yet there remain many niches in basic biological inquiry for which nematodes would be ideal model systems of study....Full Text Available

2006-09-01

500