Sample records for chancroid

  1. Chancroid and Haemophilus ducreyi: an update.

    Trees, D L; Morse, S A


    Haemophilus ducreyi is a fastidious gram-negative bacillus that causes the sexually transmitted infection chancroid. Chancroid is a major genital ulcerative disease in Africa, Southeast Asia, the Caribbean, and Latin America and is of increasing concern in the United States. Genital ulcerative disease and chancroid in particular have been associated with facilitating the transmission of human immunodeficiency virus. The diagnosis of chancroid based on the clinical appearance of the genital le...

  2. Chancroid

    ... ulcer may look like the sore of primary syphilis (chancre). About half of the people who are ... be checked for other sexually transmitted infections, including syphilis , HIV , and genital herpes . In people with HIV, ...

  3. European guideline for the management of chancroid, 2011

    Kemp, M; Christensen, J J; Lautenschlager, S;


    Chancroid is a sexually acquired disease caused by Haemophilus ducreyi. The infection is characterized by one or more genital ulcers, which are soft and painful, and regional lymphadenitis which may develop into buboes. The infection may easily be misidentified due to its rare occurrence in Europ...

  4. A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin

    Walter B. Junior


    Full Text Available A study was conducted in São Paulo, Brazil, to compare azithromycin with thiamphenicol for the single-dose treatment of chancroid. In all, 54 men with chancroid were tested. The etiology was determined by clinical characterization and direct bacterioscopy with Gram staining. None of the patients had positive serology or dark-field examination indicating active infection with Treponema pallidum. Genital infections due to Neisseria gonorrhoeae and herpes simplex virus were excluded by polymerase chain reaction testing. For 54 patients with chancroid, cure rates with single-dose treatment were 73% with azithromycin and 89% with thiamphenicol. HIV seropositivity was found to be associated with treatment failure (p=0.001. The treatment failed in all HIV positive patients treated with azithromycin (p=0.002 and this drug should be avoided in these co-infected patients. In the view of the authors, thiamphenicol is the most indicated single-dose regimen for chancroid treatment.

  5. Immune Cells Are Required for Cutaneous Ulceration in a Swine Model of Chancroid

    San Mateo, Lani R; Toffer, Kristen L.; Orndorff, Paul E.; Kawula, Thomas H.


    Cutaneous lesions of the human sexually transmitted genital ulcer disease chancroid are characterized by the presence of intraepidermal pustules, keratinocyte cytopathology, and epidermal and dermal erosion. These lesions are replete with neutrophils, macrophages, and CD4+ T cells and contain very low numbers of cells of Haemophilus ducreyi, the bacterial agent of chancroid. We examined lesion formation by H. ducreyi in a pig model by using cyclophosphamide (CPA)-induced immune cell deficienc...

  6. Minocycline versus co-trimoxazole in chancroid : A double-blind randomised study

    Oberoi C


    Full Text Available This double-blind randomised parallel-group study comparing the efficacy and side effects of minocycline with that of cotrimoxazole in chancroid, had 56 analysable cases, 28 in each group. All admissible cases were assessed clinically on a scale of 0 to 3 for number and size of ulcers, pain, discharge, surrounding erythema and bubo. Each drug individually showed significant improvement in all clinical parameters. Minocycline showed significantly better improvement than cotrimoxazole in all parameters. Minocycline had 43% cure rate, and no failures, against 36% cure and 25% failure for cotrimoxazole. Both the drug were well tolerated. We conclude that minocycline is a superior alternative to cotrimoxazole in the therapy of chancroid.

  7. Neutropenia Restores Virulence to an Attenuated Cu,Zn Superoxide Dismutase-Deficient Haemophilus ducreyi Strain in the Swine Model of Chancroid

    San Mateo, Lani R; Toffer, Kristen L.; Orndorff, Paul E.; Kawula, Thomas H.


    Haemophilus ducreyi causes chancroid, a sexually transmitted cutaneous genital ulcer disease associated with increased heterosexual transmission of human immunodeficiency virus. H. ducreyi expresses a periplasmic copper-zinc superoxide dismutase (Cu,Zn SOD) that protects the bacterium from killing by exogenous superoxide in vitro. We hypothesized that the Cu,Zn SOD would protect H. ducreyi from immune cell killing, enhance survival, and affect ulcer development in vivo. In order to test this ...

  8. A Humoral Immune Response Confers Protection against Haemophilus ducreyi Infection

    Cole, Leah E.; Toffer, Kristen L.; Fulcher, Robert A.; San Mateo, Lani R; Orndorff, Paul E.; Kawula, Thomas H.


    Haemophilus ducreyi is the etiologic agent of the sexually transmitted genital ulcer disease chancroid. Neither naturally occurring chancroid nor experimental infection with H. ducreyi results in protective immunity. Likewise, a single inoculation of H. ducreyi does not protect pigs against subsequent infection. Accordingly, we used the swine model of chancroid infection to examine the impact of multiple inoculations on a host's immune response. After three successive inoculations with H. duc...

  9. Gammabenzene hexachloride-induced convulsions in an HIV positive individual

    Panvelkar V


    Full Text Available A case report of chancroid with scabies with HIV positivity is being presented. The individual was treated with 1% gamma benzene hexachloride for scabies and developed convulsions.

  10. Complete Genome Sequences of 11 Haemophilus ducreyi Isolates from Children with Cutaneous Lesions in Vanuatu and Ghana

    Katz, Samantha S.; Abrams, A. Jeanine; Ballard, Ronald C.; Simpson, Shirley V.; Taleo, Fasihah; Lahra, Monica M.; Batra, Dhwani; Rowe, Lori; Trees, David L.; Asiedu, Kingsley; Chen, Cheng-Yen


    Haemophilus ducreyi causes chancroid and has recently been shown to be a significant cause of cutaneous lesions in tropical or subtropical regions where yaws is endemic. Here, we report the draft genome assemblies for 11 cutaneous strains of Haemophilus ducreyi, isolated from children in Vanuatu and Ghana. PMID:27389258

  11. Alteration in sample preparation to increase the yield of multiplex Polymerase Chain Reaction assay for diagnosis of genital ulcer disease

    Rao, G.; A Das; Prabhakar, P.; V Nema; Risbud, A. R.


    Purpose: Genital Ulcer Disease (GUD) is common sexually transmitted infection (STI). Multiple studies have shown that GUDs are strongly associated with the transmission and the acquisition of HIV infection. An accurate diagnosis of common etiology of GUD namely Herpes, syphilis and Chancroid is possible using Multiplex PCR (M-PCR). However, frequent presence of Polymerase Chain Reaction inhibitors in the ulcer swab specimen limits the performance of the assay. In order to overcome this proble...

  12. Identification and Characterization of the N-Acetylglucosamine Glycosyltransferase Gene of Haemophilus ducreyi

    Sun, Shuhua; Scheffler, N. Karoline; Gibson, Bradford W.; Wang, Jing; Munson Jr., Robert S.


    Haemophilus ducreyi is the causative agent of chancroid, a sexually transmitted ulcerative disease. In the present study, the Neisseria gonorrhoeae lgtA lipooligosaccharide glycosyltransferase gene was used to identify a homologue in the genome of H. ducreyi. The putative H. ducreyi glycosyltransferase gene (designated lgtA) was cloned and insertionally inactivated, and an isogenic mutant was constructed. Structural studies demonstrated that the lipooligosaccharide isolated from the mutant st...

  13. Swine model of Haemophilus ducreyi infection.

    Hobbs, M M; San Mateo, L R; Orndorff, P E; Almond, G; Kawula, T H


    Haemophilus ducreyi is a strict human pathogen that causes sexually transmitted genital ulcer disease. We infected domestic swine with H. ducreyi 35000, resulting in the development of cutaneous ulcers histologically resembling human chancroid lesions. Intraepidermal lesions progressed from pustules to ulcers containing polymorphonuclear leukocytes and were accompanied by a dermal inflammatory infiltrate containing T cells and macrophages. H. ducreyi was recovered from lesions up to 17 days a...

  14. Syndromes Associated with Sexually Transmitted Infections

    Max Chernesky; David Patrick; Rosanna Peeling


    Excellent technologies have been developed to identify the specific microbial agents of chlamydia, gonorrhea, syphilis, herpes, chancroid, trichomoniasis, human papillomavirus and HIV infection. However, it is also crucial to recognize syndromes that may be caused by one or more sexually transmitted pathogens. When laboratory services are lacking or are inadequate to provide timely results to enable appropriate treatment, some patients must be managed and treated syndromically. Most Canadian ...

  15. Profile Of Sexually Transmitted Diseases In A Clinic In The Suburb Of Kolkata (West Bengal

    Jaiswal A K


    Full Text Available Records of new STD patients attending the Base Hospital, Barrackpore, near Kolkata between 1991 and 2000 were analysed to examine the pattern of STDs among them. Among 567 new STD patients examined, syphilis predominated, followed by gonorrhoea, chancroid, genital warts, lymphogramuloma venereum and herpes genitalis. Non- gonococcal urethritis constituted 4.2% of study population. The overall HIV seropositivity showed a rising treads in the recent past.


    Devinder Mohan Thappa; Ramassamy Sivaranjini


    Venereology-the study of venereal diseases or more recently, the sexually transmitted infections (STI) includes a variety of pathogens namely viruses, bacteria, fungi and protozoa for which the common factor is the mode of transmission and acquisition: Sexual relations between human beings. Medical and other historians have often suggested that well-known diseases such as syphilis, gonorrhea, chancroid and lymphogranuloma venereum have existed since earliest times. However, it is difficult to...

  17. Study of genital lesions

    Anand Kumar B


    Full Text Available A total of one hundred patients (75 males and 25 females age ranged from 17-65 years with genital lesions attending the STD clinic of Bowring and LC Hospitals Bangalore constituted the study group. Based on clinical features, the study groups were classified as syphilis (39, chancroid (30, herpes genitolis (13, condylomato lato (9, LGV (7t condylomata acuminata (5, genital scabies (3, granuloma inguinole (2 and genital candidiasis (1. In 68% microbiological findings confirmed the clinical diagnosis. Of the 100 cases 13% and 2% were positive for HIV antibodies and HbsAg respectively.

  18. Disease: H00305 [KEGG MEDICUS

    Full Text Available ycin [DR:D08526] Pregnant women should be treated with either erythromycin or ceftriaxone regimens. clinical manifestations, diagnosis, and management. Sex Transm Infect 79:68-7...ol 42:182-90 (2003) PMID:15918786 (description) Annan NT, Lewis DA Treatment of chancroid in resource-poor c...der bacterium Haemophilus ducreyi. It is a classical genito-ulcerative disease accom...lidum, and herpes simplex virus types 1 and 2 from genital ulcers. J Clin Microbiol 34:49-54 (1996) ...

  19. Syndromes Associated with Sexually Transmitted Infections

    Max Chernesky


    Full Text Available Excellent technologies have been developed to identify the specific microbial agents of chlamydia, gonorrhea, syphilis, herpes, chancroid, trichomoniasis, human papillomavirus and HIV infection. However, it is also crucial to recognize syndromes that may be caused by one or more sexually transmitted pathogens. When laboratory services are lacking or are inadequate to provide timely results to enable appropriate treatment, some patients must be managed and treated syndromically. Most Canadian laboratories should be able to provide diagnostic services to determine the etiology of syndromes such as cervicitis, urethritis, pelvic inflammatory disease, prostatitis, genital ulcers, sexually transmitted infection (STI-related enteric infections, epididymitis, hepatitis, ophthalmia neonatorum, vulvovaginitis and vaginosis.

  20. Production of monoclonal antibodies specific for Haemophilus ducreyi: a screening method to discriminate specific and cross-reacting antibodies.

    Odumeru, J A; Alfa, M J; Martin, C F; Ronald, A R; Jay, F T


    Haemophilus ducreyi is the etiological agent of chancroid. The organism shares extensive immunological cross-reactivity with other Haemophilus species. This presents substantial difficulties for the production of specific monoclonal antibodies (MAbs). A competition ELISA was devised for hybridoma screening which allowed the detection of H. ducreyi-specific antibody-producing hybridoma cultures during the initial screening process. With this screening method, seven MAbs specific for H. ducreyi were obtained in a single cell fusion exercise. The specificities of the 7 MAbs were demonstrated by direct ELISA and dot immunobinding assays against several strains each of H. influenzae, H. parainfluenzae and Neisseria gonorrhoeae. Five of the MAbs reacted against all ten strains of H. ducreyi. These MAbs may permit the development of rapid and efficient immunodiagnostics for chancroid. The principle of the competition ELISA for hybridoma screening should be widely applicable to the development of specific MAbs to other organisms in which immunological cross-reactivity is an impediment to hybridoma screening by conventional methods. PMID:2787274

  1. Pattern of childhood STDs in a major hospital of East Delhi

    Bhogal C


    Full Text Available Of the 1418 patients with STDs, who attended the STD clinic between January 1996 to December 2000, 50 (3.4% were children below 14 years of age. Boys (29 were more than girls (21. Syphilis was the most common STD found in these children (46.8%, followed by vulvo-vaginal candidiasis (19.2%, condylomata acuminata (10.6%, gonorrhoea (8.5%, herpes progenitalis (6.4%, chancroid (4.3%, perianal candidosis and perianal molluscum contagiosum (2.1 % each. Three children had more than one STD. A history of sexual abuse could be elicited in 30 children (60%, none of the children were positive of HIV. All children with symptoms pertaining to their genitourinary system should be evaluated thoroughtly for sexual abuse.

  2. Diseño y evaluación de nuevas técnicas de diagnóstico serológico y molecular para el diagnóstico de las infecciones de transmisión sexual

    Fernández Rivas, Gema


    El terme infeccions de transmissió sexual (ITS) inclou una sèrie de síndromes causats per agents patògens que poden ser adquirits mitjançant l'activitat sexual am un augment de la seva als últims anys. Sota el concepte d'ITS s'agrupen tant les malalties venèries clàssiques (uretritis, sífilis, chancroide i limfogranuloma veneri) i aquelles en què la via sexual no és l'únic (hepatitis B i C, l'amebiasis intestinal en HSH, la infecció per virus de la immunodeficiència humana (VIH) i algunes...

  3. Patología infecciosa: vulvovaginitis, enfermedades de transmisión sexual, enfermedad inflamatoria pélvica, abscesos tubo-ováricos Infectious pathology: vulvovaginitis, sexually transmitted diseases, pelvic inflammatory disease, tubo-ovarian abscesses

    M. Ibarrola


    Full Text Available Las enfermedades de transmisión sexual son aquellas en las que la principal vía de infección es el contacto íntimo. Son numerosas las pacientes que acuden a urgencias por esta causa, tanto por la clínica como por las implicaciones sociales. Los síntomas más frecuentes son dolor abdominal bajo, sangrados vaginales, o flujo vaginal excesivo o molesto. Las vulvovaginitis son uno de los problemas principales en la práctica clínica diaria del ginecólogo. La úlcera genital cuya etiología principal es el herpes, seguida de la sífilis y el chancroide incrementa el riesgo para contraer la infección por el VIH y modifica el curso de otras enfermedades de transmisión sexual. La enfermedad pélvica inflamatoria engloba a las infecciones del tracto genital superior femenino. La importancia del diagnóstico precoz y su tratamiento adecuado reside tanto por las complicaciones en la fase aguda como por las secuelas, que incluyen el dolor crónico y la esterilidad.Sexually transmitted diseases are those where the principal path of infection is through intimate contact. Numerous patients attend Accidents and emergencies for this reason, both because of the clinical features and because of social implications. The most frequent symptoms are lower abdominal pain, vaginal bleeding or excessive or troubling vaginal flow. Vulvovaginites are one of the principal problems in the everyday clinical practice of gynaecology. A genital ulcer whose principal aetiology is herpes, followed by syphilis and chancroid, increases the risk of contracting HIV infection and alters the course of other sexually transmitted diseases. Inflammatory pelvic disease encompasses infections of the upper female genital tract. The importance of early diagnosis and suitable treatment is both due to the complications in its acute phase and to its sequels, which include chronic pain and sterility.

  4. Medical Examination of Aliens--Revisions to Medical Screening Process. Final rule.


    The Centers for Disease Control and Prevention (CDC), within the Department of Health and Human Services (HHS), is issuing this final rule (FR) to amend its regulations governing medical examinations that aliens must undergo before they may be admitted to the United States. Based on public comment received, HHS/CDC did not make changes from the NPRM published on June 23, 2015. Accordingly, this FR will: Revise the definition of communicable disease of public health significance by removing chancroid, granuloma inguinale, and lymphogranuloma venereum as inadmissible health-related conditions for aliens seeking admission to the United States; update the notification of the health-related grounds of inadmissibility to include proof of vaccinations to align with existing requirements established by the Immigration and Nationality Act (INA); revise the definitions and evaluation criteria for mental disorders, drug abuse and drug addiction; clarify and revise the evaluation requirements for tuberculosis; clarify and revise the process for the HHS/CDC-appointed medical review board that convenes to reexamine the determination of a Class A medical condition based on an appeal; and update the titles and designations of federal agencies within the text of the regulation. PMID:26812891

  5. Molecular phylogenetic analysis of non-sexually transmitted strains of Haemophilus ducreyi.

    Jordan R Gaston

    Full Text Available Haemophilus ducreyi, the etiologic agent of chancroid, has been previously reported to show genetic variance in several key virulence factors, placing strains of the bacterium into two genetically distinct classes. Recent studies done in yaws-endemic areas of the South Pacific have shown that H. ducreyi is also a major cause of cutaneous limb ulcers (CLU that are not sexually transmitted. To genetically assess CLU strains relative to the previously described class I, class II phylogenetic hierarchy, we examined nucleotide sequence diversity at 11 H. ducreyi loci, including virulence and housekeeping genes, which encompass approximately 1% of the H. ducreyi genome. Sequences for all 11 loci indicated that strains collected from leg ulcers exhibit DNA sequences homologous to class I strains of H. ducreyi. However, sequences for 3 loci, including a hemoglobin receptor (hgbA, serum resistance protein (dsrA, and a collagen adhesin (ncaA contained informative amounts of variation. Phylogenetic analyses suggest that these non-sexually transmitted strains of H. ducreyi comprise a sub-clonal population within class I strains of H. ducreyi. Molecular dating suggests that CLU strains are the most recently developed, having diverged approximately 0.355 million years ago, fourteen times more recently than the class I/class II divergence. The CLU strains' divergence falls after the divergence of humans from chimpanzees, making it the first known H. ducreyi divergence event directly influenced by the selective pressures accompanying human hosts.

  6. Sexual transmission of human T-cell lymphotropic virus type 1

    Arthur Paiva


    Full Text Available Human T-cell lymphotropic virus type 1 (HTLV-1 is endemic in many parts of the world and is primarily transmitted through sexual intercourse or from mother to child. Sexual transmission occurs more efficiently from men to women than women to men and might be enhanced by sexually transmitted diseases that cause ulcers and result in mucosal ruptures, such as syphilis, herpes simplex type 2 (HSV-2, and chancroid. Other sexually transmitted diseases might result in the recruitment of inflammatory cells and could increase the risk of HTLV-1 acquisition and transmission. Additionally, factors that are associated with higher transmission risks include the presence of antibodies against the viral oncoprotein Tax (anti-Tax, a higher proviral load in peripheral blood lymphocytes, and increased cervicovaginal or seminal secretions. Seminal fluid has been reported to increase HTLV replication and transmission, whereas male circumcision and neutralizing antibodies might have a protective effect. Recently, free virions were discovered in plasma, which reveals a possible new mode of HTLV replication. It is unclear how this discovery might affect the routes of HTLV transmission, particularly sexual transmission, because HTLV transmission rates are significantly higher from men to women than women to men.

  7. Alteration in sample preparation to increase the yield of multiplex Polymerase Chain Reaction assay for diagnosis of genital ulcer disease

    G Rao


    Full Text Available Purpose: Genital Ulcer Disease (GUD is common sexually transmitted infection (STI. Multiple studies have shown that GUDs are strongly associated with the transmission and the acquisition of HIV infection. An accurate diagnosis of common etiology of GUD namely Herpes, syphilis and Chancroid is possible using Multiplex PCR (M-PCR. However, frequent presence of Polymerase Chain Reaction inhibitors in the ulcer swab specimen limits the performance of the assay. In order to overcome this problem, alternative specimen preparation method was used. Materials and Methods: To determine the common etiology, GUD specimens obtained under an STI operations research study were tested with M-PCR after the samples were prepared using Roche Amplicor specimen preparation kit. PCR inhibiting samples were identified from that, which showed negative results. These samples were subjected to phenol-chloroform extraction and ethanol precipitation before the conduct of M-PCR on them. Results: Of the 237 GUD specimens tested, in 145 etiologies could be detected, whereas 92 samples were found negative. Further spiking with one of the target DNA, 128 of the negative samples were found to contain the inhibitors. These 126 samples were then subjected to phenol chloroform extraction and ethanol precipitation followed by M-PCR. Using this method for sample preparation, etiology could be determined in 46 (23% additional samples. This success rate of altered sample preparation method has been lower than that has reported. Conclusion: The results indicate that sample preparation using phenol chloroform extraction and ethanol precipitation, prior to M-PCR helps to eliminate the inhibitors and increase the yield of the assay. However, being a laborious procedure, it may be used for samples giving negative results after the screening by Roche Amplicor specimen preparation kit.

  8. Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey.

    Virginia Homfray

    Full Text Available It is well-established that male circumcision reduces acquisition of HIV, herpes simplex virus 2, chancroid, and syphilis. However, the effect on the acquisition of non-ulcerative sexually transmitted infections (STIs remains unclear. We examined the relationship between circumcision and biological measures of three STIs: human papillomavirus (HPV, Chlamydia trachomatis and Mycoplasma genitalium.A probability sample survey of 15,162 men and women aged 16-74 years (including 4,060 men aged 16-44 years was carried out in Britain between 2010 and 2012. Participants completed a computer-assisted personal interview, including a computer-assisted self-interview, which asked about experience of STI diagnoses, and circumcision. Additionally, 1,850 urine samples from sexually-experienced men aged 16-44 years were collected and tested for STIs. Multivariable logistic regression was used to calculate adjusted odds ratios (AOR to quantify associations between circumcision and i self-reporting any STI diagnosis and ii presence of STIs in urine, in men aged 16-44 years, adjusting for key socio-demographic and sexual behavioural factors.The prevalence of circumcision in sexually-experienced men aged 16-44 years was 17.4% (95%CI 16.0-19.0. There was no association between circumcision and reporting any previous STI diagnoses, and specifically previous chlamydia or genital warts. However, circumcised men were less likely to have any HPV type (AOR 0.26, 95% confidence interval (CI 0.13-0.50 including high-risk HPV types (HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and/or 68 (AOR 0.14, 95% CI 0.05-0.40 detected in urine.Circumcised men had reduced odds of HPV detection in urine. These findings have implications for improving the precision of models of STI transmission in populations with different circumcision prevalence and in designing interventions to reduce STI acquisition.

  9. A study on sexually transmitted diseases in patients in a STD clinic in a district hospital in North India

    Neerja Puri


    Full Text Available Introduction: The Sexually transmitted diseases (STDs are a global health problem of great magnitude. The pattern of STDs differs from country to country and from region to region. The increased risk of the transmission of HIV is known to be associated with the presence of sexually transmitted diseases (STDs and despite the presence of the National STD Control Program in India the number of people with STDs remains high. Aim: The aim of our study was to study the profile of patients in a STD clinic in North India and to study various sexually transmitted infections in both male and female patients. Material and Methods: A prospective study of the patients attending STD clinic in a district hospital in North India from December 2009 to December 2012 was done. A total of 2700 patients attending the STDclinic in three years from December 2009 to December 2012 were taken up for the study. Results: The commonest sexually transmitted infection in males was herpes genitalis (30% followed by 20% cases of genital warts. 10% patients had gonorrhoea, genital molluscum contagiosum, syphilis and genital scabies each and 5% patients had nongonococcal urethritis. Only 5% of the total patients had chancroid, donovanosis and LGV. The commonest sexually transmitted infection in females was vaginal discharge seen in 40% patients, lower abdominal pain in 20% patients, herpes genitalis in 15% patients followed by 20% cases of genital warts and syphilis each. Genital molluscum contagiosum was seen in 5% patients only. Conclusions: The treatment of STD’s is important as both non-ulcerative and ulcerative STDs increase the susceptibility to or transmissibility of HIV infection and as such, an increase in STD prevalence as revealed by clinic attendance in this study was bound to facilitate the spread of HIV/AIDS. Perhaps it is high time health planners adopted a more aggressive and result oriented HIV/AIDS/STD awareness campaign strategy.

  10. Reproductive and Sexual Health of Chinese Migrants

    Jian-fang ZHOU; Joanna E Mantell; Xiao-mei RU


    Objective To investigate the reproductive and sexual health situation,including knowledge,attitudes,and behaviors,among a population-based sample of internal migrant workers in China.Methods A cross-sectional survey of 4 900 rural-to-urban migrants in 6 provinces of China was conducted.Participants completed a 30-min semi-structured questionnaire about contraceptive practices,sexual behavior,and HIV-related knowledge.Results Migrants lacked knowledge of reproductive and sexual health issues.Among those who had heard any sexually transmitted infections(STIs),only 79.1%,46.2%,86.1%,14.5% and 82.2%,respectively,knew that gonorrhea,condyloma,syphilis,chancroid,and AIDS were STIs.About three-quarters of participants had not used any contraceptive method at sexual debut.Among current users of contraceptive methods,85.5% indicated that they were satisfied with the method.Before adoption of a contraceptive method,46.6% of the migrant workers were unaware of the advantages/disadvantages of the method and 75.3% had no knowledge of emergency contraception.Nearly one-quarter(23.4%)reported that they had premarital sex.Among migrants who were sexually active one month prior to the survey,only 14.0% reported that they had used condoms.Conclusion The limited sexual and reproductive health knowledge and unmet reproductive health services of migrant workers in China underscore the need for a comprehensive package of sexual and reproductive health interventions that combine cognitive and behavioral skills training and target both migrants and health care providers.

  11. Updates of research on STD vaccines%性病相关性疫苗研究现状



    疫苗是控制传染病流行的最有效的手段之一.近年来在性病疫苗研究中有所突破,人乳头瘤病毒(Human papillomavirus,HPV)感染的预防性疫苗研究获得了很大成功,已有2种HPV预防性疫苗上市.HPV四价疫苗可用于预防宫颈癌、肛门生殖器癌前病变及肛门生殖器疣,二价疫苗仅用于预防宫颈癌及癌前病变.生殖器疱疹的疫苗已经进入临床试验阶段,但是Ⅱ型单纯疱疹病毒(Herpes simplex virus type 2,HSV-2)糖蛋白D亚单位疫苗在三期临床试验中失败,无预防生殖器HSV-2感染的作用.其他性病诸如沙眼衣原体感染、淋病、梅毒、软下疳的疫苗研制仍处于实验室探索阶段.%Objective Vaccine is one of the most effective strategies in the control of infectious diseases. The development of vaccines against pathogens causing sexully transmitted diseases (STD)has gained breakthrough in recent years and prophylactic vaccines against HPV has been a major success. Two kinds of HPV vaccines have been licensed. Quadrivalent HPV vaccine is effective in preventing cervical cancer, anal-genital precancerous lesions and anal-genital warts, while bivalent vaccine is effective in preventing cervical cancer and their precancerous lesions. HSV Glycoprotein-D-adjuvant vaccine has been tested in clinical trials, but failed to prevent HSV-2 infection. Vaccines against other STD such as Chlamydia trachomotis infection, gonorrhea, syphilis and chancroid are still under

  12. Sexually transmitted diseases in children in developing countries.

    Richens, J


    under more narrowly-defined cultural norms. For example, the belief exists that a male with urethritis can be cured by sexual intercourse with a virgin or prepubertal girl. Elsewhere, it is normal practice for an adult male, typically a boy's uncle, to have anal insertive sexual intercourse with the boy on a regular basis over the period of a couple years to facilitate his transition into manhood. People in young age groups around the world have sex for a range of reasons under a variety of conditions. Measures are needed to ensure that they have the means to prevent infection with STDs and control that infection, if possible, once acquired. Sections discuss vulvovaginitis, donovanosis, chancroid, and venereal and nonvenereal treponematosis, as well as prevention and future research. PMID:7959715

  13. Knowledge and acceptance of sex education at Agbo-Oba, Ilorin, Kwara State, Nigeria.

    Ebomoyi, E; Elimian, A A


    Data on knowledge about and attitudes toward sex education was collected from 178 females and 224 males, 15 years of age or older, who resided in a random sample of 243 households in Agbo-Oba, an urban center located in the Ilorin area of Kwara, Nigeria. Nigerian youth are rarely exposed to sex education in the schools; yet, they are increasingly exposed to the portrayal of irresponsible sex and pornography in imported films, books, and magazines. The present study assessed the need for sex education in Nigerian society and examined public attitudes toward sex education. Percent distributions were used to analyze the material. 63.4% of the male respondents and 70.2% of the female respondents had some knowledge of sex education. The proportion of those with knowledge of sex education increased with educational level. In all age groups, at least 60% of the respondents knew about sex education. Respondents' sources of sex education included parents (24.6%), friends (36.8%), school teachers (18.4%), books and magazines (64.7%), health personnel (6%), and churches (1.5%). Respondent knowledge of specific components of sex education was limited. For example, only 55.45 recognized contraception as a component of sex education, and only 37.1% considered the dissemination of information on sexually transmitted diseases to be a part of sex education. Only 9.2% of the respondents were satisfied with their current level of sexual knowledge. 95.3% knew about gonorrhea, and 47.8% knew about syphilis, but only 12.2% knew about herpes, and only 7.7% knew about chancroid. 65.1% of the Moslems and 78.4% of the Christian respondents, or 74.1% of all the respondents, agreed that there was a need for sex education in Nigerian society. The proportion who agreed increased with educational level. Among those who were receptive to sex education, 88.3% said it should be taught by health personnel; 59.7%, by parents; 42.3%, by school teachers; 11.4%, by religious institutions; and 9.7%, by