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Sample records for chabaudi adami single

  1. Taxol arrests the development of blood-stage Plasmodium falciparum in vitro and Plasmodium chabaudi adami in malaria-infected mice.

    Pouvelle, B; Farley, P J; Long, C A; Taraschi, T.F.

    1994-01-01

    Taxol, a natural product used to treat a variety of human cancers, is shown here to be extremely effective against chloroquine- and pyrimethamine-resistant malaria parasites. Addition of Taxol (1.0 microM) for one cycle to cultures of human erythrocytes infected with Plasmodium falciparum prevents the establishment of new infections. Blood parasitemia is eliminated in mice infected with Plasmodium chabaudi adami when they are given a single intraperitoneal injection of Taxol at 150 mg/m2. The...

  2. Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

    Alves Ana C

    2010-05-01

    Full Text Available Abstract Background Plasmodium falciparum, has developed resistance to many of the drugs in use. The recommended treatment policy is now to use drug combinations. The atovaquone-proguanil (AP drug combination, is one of the treatment and prophylaxis options. Atovaquone (ATQ exerts its action by inhibiting plasmodial mitochondria electron transport at the level of the cytochrome bc1 complex. Plasmodium falciparum in vitro resistance to ATQ has been associated with specific point mutations in the region spanning codons 271-284 of the cytochrome b gene. ATQ -resistant Plasmodium yoelii and Plasmodium berghei lines have been obtained and resistant lines have amino acid mutations in their CYT b protein sequences. Plasmodium chabaudi model for studying drug-responses and drug-resistance selection is a very useful rodent malaria model but no ATQ resistant parasites have been reported so far. The aim of this study was to determine the ATQ sensitivity of the P. chabaudi clones, to select a resistant parasite line and to perform genotypic characterization of the cytb gene of these clones. Methods To select for ATQ resistance, Plasmodium. chabaudi chabaudi clones were exposed to gradually increasing concentrations of ATQ during several consecutive passages in mice. Plasmodium chabaudi cytb gene was amplified and sequenced. Results ATQ resistance was selected from the clone AS-3CQ. In order to confirm whether an heritable genetic mutation underlies the response of AS-ATQ to ATQ, the stability of the drug resistance phenotype in this clone was evaluated by measuring drug responses after (i multiple blood passages in the absence of the drug, (ii freeze/thawing of parasites in liquid nitrogen and (iii transmission through a mosquito host, Anopheles stephensi. ATQ resistance phenotype of the drug-selected parasite clone kept unaltered. Therefore, ATQ resistance in clone AS-ATQ is genetically encoded. The Minimum Curative Dose of AS-ATQ showed a six

  3. Gulella adami, a new species of land snail from the Ivory Coast, West Africa (Gastropoda Pulmonata: Streptaxidae)

    Bruggen, van, A.C.

    1994-01-01

    Gulella adami spec. nov. is described from a classical West African locality, Assini in the Ivory Coast (Côte d'Ivoire). It is most unusual in showing two superficial parietal processes, which may also be interpreted as a double angular lamella, in the aperture of the shell. The shell closely resembles that of various Enidae in SE Europe and adjoining areas around the Mediterranean, thereby providing a striking example of convergent evolution.

  4. Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS

    Lawton Jennifer

    2012-03-01

    Full Text Available Abstract Background The pir genes comprise the largest multi-gene family in Plasmodium, with members found in P. vivax, P. knowlesi and the rodent malaria species. Despite comprising up to 5% of the genome, little is known about the functions of the proteins encoded by pir genes. P. chabaudi causes chronic infection in mice, which may be due to antigenic variation. In this model, pir genes are called cirs and may be involved in this mechanism, allowing evasion of host immune responses. In order to fully understand the role(s of CIR proteins during P. chabaudi infection, a detailed characterization of the cir gene family was required. Results The cir repertoire was annotated and a detailed bioinformatic characterization of the encoded CIR proteins was performed. Two major sub-families were identified, which have been named A and B. Members of each sub-family displayed different amino acid motifs, and were thus predicted to have undergone functional divergence. In addition, the expression of the entire cir repertoire was analyzed via RNA sequencing and microarray. Up to 40% of the cir gene repertoire was expressed in the parasite population during infection, and dominant cir transcripts could be identified. In addition, some differences were observed in the pattern of expression between the cir subgroups at the peak of P. chabaudi infection. Finally, specific cir genes were expressed at different time points during asexual blood stages. Conclusions In conclusion, the large number of cir genes and their expression throughout the intraerythrocytic cycle of development indicates that CIR proteins are likely to be important for parasite survival. In particular, the detection of dominant cir transcripts at the peak of P. chabaudi infection supports the idea that CIR proteins are expressed, and could perform important functions in the biology of this parasite. Further application of the methodologies described here may allow the elucidation of CIR sub

  5. The role of regulatory T cells during Plasmodium chabaudi chabaudi AS infection in BALB/c mice.

    Pang, W; Sun, X; Feng, H; Wang, J; Cui, L; Cao, Y

    2016-07-01

    An inappropriate immune response to parasite infection is one of the primary drivers of malaria pathogenesis. Regulatory T cells (Tregs), an important subset of CD4(+) T cells, can maintain self-tolerance and prevent autoimmune diseases. However, there is little consensus about their role in malaria pathogenesis. In this study, we transiently depleted Tregs (CD25(+) T cells) using an anti-CD25 mAb (7D4 clone) at different time points following Plasmodium chabaudi chabaudi AS infection in BALB/c mice and investigated the effect of depletion of Tregs in this model. In control mice, Tregs proliferated significantly and their suppressive function was enhanced after infection. IL-10 was increased drastically during infection. Depletion of Tregs at various time points can lead to divergent outcomes. When Tregs were depleted prior to or during the early phase of infection, most mice survived and had a robust Th1 immune response. In contrast, when Tregs were depleted close to peak parasitemia, all mice died as a result of inflammation. Taken together, these data suggest that in P. c. chabaudi AS-infected BALB/c mice, Tregs inhibit the Th1 response and macrophage activation, leading to increased parasite load; however, they also control inflammation-mediated pathology by secreting high levels of IL-10. PMID:27139002

  6. Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS)

    Lawton, Jennifer

    2012-03-29

    Background: The pir genes comprise the largest multi-gene family in Plasmodium, with members found in P. vivax, P. knowlesi and the rodent malaria species. Despite comprising up to 5% of the genome, little is known about the functions of the proteins encoded by pir genes. P. chabaudi causes chronic infection in mice, which may be due to antigenic variation. In this model, pir genes are called cirs and may be involved in this mechanism, allowing evasion of host immune responses. In order to fully understand the role(s) of CIR proteins during P. chabaudi infection, a detailed characterization of the cir gene family was required.Results: The cir repertoire was annotated and a detailed bioinformatic characterization of the encoded CIR proteins was performed. Two major sub-families were identified, which have been named A and B. Members of each sub-family displayed different amino acid motifs, and were thus predicted to have undergone functional divergence. In addition, the expression of the entire cir repertoire was analyzed via RNA sequencing and microarray. Up to 40% of the cir gene repertoire was expressed in the parasite population during infection, and dominant cir transcripts could be identified. In addition, some differences were observed in the pattern of expression between the cir subgroups at the peak of P. chabaudi infection. Finally, specific cir genes were expressed at different time points during asexual blood stages.Conclusions: In conclusion, the large number of cir genes and their expression throughout the intraerythrocytic cycle of development indicates that CIR proteins are likely to be important for parasite survival. In particular, the detection of dominant cir transcripts at the peak of P. chabaudi infection supports the idea that CIR proteins are expressed, and could perform important functions in the biology of this parasite. Further application of the methodologies described here may allow the elucidation of CIR sub-family A and B protein

  7. Bacillus Calmette-Guérin-inoculation at different time points influences the outcome of C57BL/6 mice infected with Plasmodium chabaudi chabaudi AS.

    Cao, Dong-Hua; Wang, Ji-Chun; Liu, Jun; Du, Yun-Ting; Cui, Li-Wang; Cao, Ya-Ming

    2016-01-01

    Bacillus Calmette-Guérin (BCG) is an attenuated Mycobacterium tuberculosis vaccine. We performed a series of co-infection experiments with BCG-Plasmodium chabaudi chabaudi Landau, 1965 AS using C57BL/6 mice to analyse whether BCG can affect the development of protective immunity to infection with Plasmodium spp. and the mechanism of this protection. We divided mice into four groups: BCG-inoculation 4 weeks prior to P. c. chabaudi AS infection (B-4w-Pc); simultaneous BCG-inoculation and P. c. chabaudi AS infection (Pc+B); BCG-inoculation 3 days post P. c. chabaudi AS (Pc-3-B) infection; and mono-P. c. chabaudi AS infection as control (Pc). The parasitemia level in the B-4w-Pc group was noticeably higher than control group at 6-19 days post infection (dpi). Compared with the control group, the proportion of CD4(+)CD69(+) T cells was significantly reduced 5, 8 and 12 dpi, but the proportion of CD4(+)CD25(+)Foxp3(+) Tregs was significantly increased in the B-4w-Pc group on 5 and 8 dpi. The B-4w-Pc group also demonstrated reduced levels of IFN-γ and TNF-α on 5 and 8 dpi and significantly elevated level of IL-10 on 12 dpi. There were significantly fewer mDCs (CD11c(+)CD11b(+)) and pDCs (CD11c(+)B220(+)) in the B-4w-Pc group than the control group at all the time points post infection and the expression of MHC II was noticeably reduced on day 8 pi. Our findings confirmed that BCG inoculation prior to Plasmodium infection resulted in excessive activation and proliferation of Tregs and upregulation of anti-inflammatory mediators, which inhibited establishment of a Th1-dominant immune response during the early stages of Plasmodium infection by inhibiting dendritive cells response. BCG inoculation prior to P. c. chabaudi AS infection may contribute to overgrowth of parasites as well as mortality in mice. PMID:27188912

  8. The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi.

    Victoria C Barclay

    Full Text Available Malaria vaccine developers are concerned that antigenic escape will erode vaccine efficacy. Evolutionary theorists have raised the possibility that some types of vaccine could also create conditions favoring the evolution of more virulent pathogens. Such evolution would put unvaccinated people at greater risk of severe disease. Here we test the impact of vaccination with a single highly purified antigen on the malaria parasite Plasmodium chabaudi evolving in laboratory mice. The antigen we used, AMA-1, is a component of several candidate malaria vaccines currently in various stages of trials in humans. We first found that a more virulent clone was less readily controlled by AMA-1-induced immunity than its less virulent progenitor. Replicated parasites were then serially passaged through control or AMA-1 vaccinated mice and evaluated after 10 and 21 rounds of selection. We found no evidence of evolution at the ama-1 locus. Instead, virulence evolved; AMA-1-selected parasites induced greater anemia in naïve mice than both control and ancestral parasites. Our data suggest that recombinant blood stage malaria vaccines can drive the evolution of more virulent malaria parasites.

  9. Studies in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum: interferon-g and interleukin-4 mRNA expression

    Cláudia S Marques

    2005-12-01

    Full Text Available This work aimed to study the T helper type 1/2 (Th1/Th2 cytokine profile in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum. Expression of interferon-gamma (IFN-g and interleukin-4 (IL-4 was analyzed, in spleen and liver of C57BL/6 mice, by reverse transcriptase-polymerase chain reaction. High levels of IFN-g expression did not prevent the progression of Leishmania in co-infected mice and Leishmania infection did not interfere with the Th1/Th2 switch necessary for Plasmodium control. The presence of IL-4 at day 28 in co-infected mice, essential for Plasmodium elimination, was probably a key factor on the exacerbation of the Leishmania infection.

  10. Genetic Immunization of BALB/c mice with a Plasmid Bearing the Gene Coding for a Hybrid Merozoite Surface Protein 1-Hepatitis B Virus Surface Protein Fusion Protects Mice against Lethal Plasmodium chabaudi chabaudi PC1 Infection

    Wunderlich, Gerhard; Moura, Ivan C.; del Portillo, Hernando A

    2000-01-01

    The genetic immunization of rodents with a plasmid coding for a Plasmodium chabaudi merozoite surface protein 1 (C terminus)-hepatitis B virus surface fusion protein (pPcMSP119-HBs) provided protection of mice against subsequent lethal challenge with P. chabaudi chabaudi PC1-infected red blood cells. The percentage of survivor mice was higher in DNA-immunized mice than in animals immunized with a recombinant rPcMSP119– glutathione S-transferase fusion protein administered in Freund adjuvant. ...

  11. Cytokine responses of CD4+ T cells during a Plasmodium chabaudi chabaudi (ER blood-stage infection in mice initiated by the natural route of infection

    Butcher Geoffrey

    2007-06-01

    Full Text Available Abstract Background Investigation of host responses to blood stages of Plasmodium spp, and the immunopathology associated with this phase of the life cycle are often performed on mice infected directly with infected red blood cells. Thus, the effects of mosquito bites and the pre-erythrocytic stages of the parasite, which would be present in natural infection, are ignored In this paper, Plasmodium chabaudi chabaudi infections of mice injected directly with infected red blood cells were compared with those of mice infected by the bites of infected mosquitoes, in order to determine whether the courses of primary infection and splenic CD4 T cell responses are similar. Methods C57Bl/6 mice were injected with red blood cells infected with P. chabaudi (ER or infected via the bite of Anopheles stephensi mosquitoes. Parasitaemia were monitored by Giemsa-stained thin blood films. Total spleen cells, CD4+ T cells, and cytokine production (IFN-γ, IL-2, IL-4, IL-10 were analysed by flow cytometry. In some experiments, mice were subjected to bites of uninfected mosquitoes prior to infectious bites in order to determine whether mosquito bites per se could affect a subsequent P. chabaudi infection. Results P. chabaudi (ER infections initiated by mosquito bite were characterized by lower parasitaemia of shorter duration than those observed after direct blood challenge. However, splenomegaly was comparable suggesting that parasitaemia alone does not account for the increase in spleen size. Total numbers of CD4 T cells and those producing IFN-γ, IL-10 and IL-2 were reduced in comparison to direct blood challenge. By contrast, the reduction in IL-4 producing cells was less marked suggesting that there is a proportionally lower Th1-like response in mice infected via infectious mosquitoes. Strikingly, pre-exposure to bites of uninfected mosquitoes reduced the magnitude and duration of the subsequent mosquito-transmitted infection still further, but enhanced the

  12. Assessment of the effect of insecticide-treated nets and indoor residual spraying for malaria control in three rural kebeles of Adami Tulu District, South Central Ethiopia

    Bekele Damtew

    2012-04-01

    Full Text Available Abstract Background In the Adami Tulu District, indoor residual spraying (IRS and insecticide-treated nets (ITNs has been the main tool used to control malaria. The purpose of this study was to assess the effect of IRS and ITNs control strategies in Aneno Shisho kebele (lowest administrative unit of Ethiopia compared with Kamo Gerbi (supplied ITN only and Jela Aluto (no IRS and ITNs, with regards to the prevalence of malaria and mosquito density. Methods Cross-sectional surveys were conducted after heavy rains (October/November, 2006 and during the sporadic rains (April, 2007 in the three kebeles of Adami Tulu District. Malaria infection was measured by means of thick and thin film. Monthly collection of adult mosquitoes from October-December 2006 and April-May 2007 and sporozoite enzyme-linked immunosorbent assay (ELISA on the collected mosquitoes were detected. Data related to the knowledge of mode of malaria transmission and its control measures were collected. Data collected on parasitological and knowledge, attitude and practice (KAP surveys were managed and analysed using a statistical computer program SPSS version 13.0. A P-value Results The overall prevalence of malaria was 8.6% in Jela Aluto, 4.4% in Kamo Gerbi and 1.3% in Aneno Shisho in the two season surveys. The vector, Anopheles gambiae s.l., Anopheles pharoensis and Anopheles coustani were recorded. However, sporozoite ELISA on mosquito collections detected no infection. The difference in overall malaria prevalence and mosquito density between the three kebeles was significant (P Conclusions The present study has provided some evidence for the success of ITNs/IRS combined malaria control measures in Aneno Shisho kebele in Adami Tulu District. Therefore, the combined ITNs/IRS malaria control measures must be expanded to cover all kebeles in the District of Ethiopia.

  13. Characterization of the Plasmodium Interspersed Repeats (PIR) proteins of Plasmodium chabaudi indicates functional diversity

    Xue Yan Yam; Thibaut Brugat; Anthony Siau; Jennifer Lawton; Wong, Daniel S.; Abdirahman Farah; Jing Shun Twang; Xiaohong Gao; Jean Langhorne; Peter R Preiser

    2016-01-01

    Plasmodium multigene families play a central role in the pathogenesis of malaria. The Plasmodium interspersed repeat (pir) genes comprise the largest multigene family in many Plasmodium spp. However their function(s) remains unknown. Using the rodent model of malaria, Plasmodium chabaudi, we show that individual CIR proteins have differential localizations within infected red cell (iRBC), suggesting different functional roles in a blood-stage infection. Some CIRs appear to be located on the s...

  14. Selection for high and low virulence in the malaria parasite Plasmodium chabaudi.

    Mackinnon, M.J.; Read, A F

    1999-01-01

    What stops parasites becoming ever more virulent? Conventional wisdom and most parasite-centred models of the evolution of virulence suppose that risk of host (and, hence, parasite) death imposes selection against more virulent strains. Here we selected for high and low virulence within each of two clones of the rodent malaria parasite Plasmodium chabaudi on the basis of between-host differences in a surrogate measure of virulence--loss of live weight post-infection. Despite imposing strong s...

  15. Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infections

    Read Andrew F; Bell Andrew S; Culleton Richard; de Roode Jacobus C

    2004-01-01

    Abstract Background Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance. Methods The effects of drug treatment on within-host competition were studied using the rodent malaria Plasmodium chabaudi. Mice were infected simultaneously with a drug-resistant and a drug-sensitive clone and were then either drug-treated or left untreated. Transmission was assessed by f...

  16. Plasmodium berghei and Plasmodium chabaudi: a neutral endopeptidase in parasite extracts and plasma of infected animals.

    Bernard, F; Mayer, R; Picard, I; Deguercy, A; Monsigny, M; Schrevel, J

    1987-08-01

    By using a sensitive fluorometric method with Val-Leu-Gly-Arg-3-amino-9-ethylcarbazole (VLGR-AEC) as a substrate, two endopeptidase activities were identified in two fractions of Sephacryl S-200 gel filtration from soluble P. berghei and P. chabaudi extracts. Controls with normal mouse erythrocytes, with leukocytes, and with reticulocyte enriched blood and different washing procedures during the preparation of soluble P. berghei extracts showed that the MW greater than 200 kDa fraction was a contaminant from erythrocytes and exhibited an optimal pH activity of 8.2. In contrast, the fraction 130 kDa was related to P. berghei and P. chabaudi and exhibited an optimal pH activity of 7.4. The two enzyme activities were compared with eight different substrates. The parasite endopeptidase showed a strong activity with Val-Leu-Gly-Lys-AEC (VLGK-AEC) and Ser-Gly-Lys-AEC (SGK-AEC) as substrates; in contrast, the mouse host endopeptidase poorly cleaved the VLGK-AEC and did not cleave SGK-AEC. Presence of the hydrophobic benzyl group on serine reduced the hydrolizing properties of P. berghei endopeptidase: the reverse was observed with host endopeptidase. The hydrolysis of the N-polyhydroxyalcanoyl-VLGK-AEC substrate by the parasite neutral endopeptidase strongly increased with the schizogonic stage, as shown with synchronized P. chabaudi in mice. By its physiological pH and specificity the release of this enzyme in mouse plasma during the infection could be of interest in a peptidyl-drug strategy. PMID:3301390

  17. Characterization and tissue-specific expression patterns of the Plasmodium chabaudi cir multigene family

    Krücken Jürgen

    2011-09-01

    Full Text Available Abstract Background Variant antigens expressed on the surface of parasitized red blood cells (pRBCs are important virulence factors of malaria parasites. Whereas Plasmodium falciparum erythrocyte membrane proteins 1 (PfEMP1 are responsible for sequestration of mature parasites, little is known about putative ligands mediating cytoadherence to host receptors in other Plasmodium species. Candidates include members of the pir superfamily found in the human parasite Plasmodium vivax (vir, in the simian pathogen Plasmodium knowlesi (kir and in the rodent malarias Plasmodium yoelii (yir, Plasmodium berghei (bir and Plasmodium chabaudi (cir. The aim of this study was to reveal a potential involvement of cir genes in P. chabaudi sequestration. Methods Subfamilies of cir genes were identified by bioinformatic analyses of annotated sequence data in the Plasmodium Genome Database. In order to examine tissue-specific differences in the expression of cir mRNAs, RT-PCR with subfamily-specific primers was used. In total, 432 cDNA clones derived from six different tissues were sequenced to characterize the transcribed cir gene repertoire. To confirm differences in transcription profiles of cir genes, restriction fragment length polymorphism (RFLP analyses were performed to compare different host tissues and to identify changes during the course of P. chabaudi infections in immunocompetent mice. Results The phylogenetic analysis of annotated P. chabaudi putative CIR proteins identified two major subfamilies. Comparison of transcribed cir genes from six different tissues revealed significant differences in the frequency clones belonging to individual cir gene subgroups were obtained from different tissues. Further hints of difference in the transcription of cir genes in individual tissues were obtained by RFLP. Whereas only minimal changes in the transcription pattern of cir genes could be detected during the developmental cycle of the parasites, switching to

  18. Rapid response to selection, competitive release and increased transmission potential of artesunate-selected Plasmodium chabaudi malaria parasites.

    Laura C Pollitt

    2014-04-01

    Full Text Available The evolution of drug resistance, a key challenge for our ability to treat and control infections, depends on two processes: de-novo resistance mutations, and the selection for and spread of resistant mutants within a population. Understanding the factors influencing the rates of these two processes is essential for maximizing the useful lifespan of drugs and, therefore, effective disease control. For malaria parasites, artemisinin-based drugs are the frontline weapons in the fight against disease, but reports from the field of slower parasite clearance rates during drug treatment are generating concern that the useful lifespan of these drugs may be limited. Whether slower clearance rates represent true resistance, and how this provides a selective advantage for parasites is uncertain. Here, we show that Plasmodium chabaudi malaria parasites selected for resistance to artesunate (an artemisinin derivative through a step-wise increase in drug dose evolved slower clearance rates extremely rapidly. In single infections, these slower clearance rates, similar to those seen in the field, provided fitness advantages to the parasite through increased overall density, recrudescence after treatment and increased transmission potential. In mixed infections, removal of susceptible parasites by drug treatment led to substantial increases in the densities and transmission potential of resistant parasites (competitive release. Our results demonstrate the double-edged sword for resistance management: in our initial selection experiments, no parasites survived aggressive chemotherapy, but after selection, the fitness advantage for resistant parasites was greatest at high drug doses. Aggressive treatment of mixed infections resulted in resistant parasites dominating the pool of gametocytes, without providing additional health benefits to hosts. Slower clearance rates can evolve rapidly and can provide a strong fitness advantage during drug treatment in both

  19. Rapid response to selection, competitive release and increased transmission potential of artesunate-selected Plasmodium chabaudi malaria parasites.

    Pollitt, Laura C; Huijben, Silvie; Sim, Derek G; Salathé, Rahel M; Jones, Matthew J; Read, Andrew F

    2014-04-01

    The evolution of drug resistance, a key challenge for our ability to treat and control infections, depends on two processes: de-novo resistance mutations, and the selection for and spread of resistant mutants within a population. Understanding the factors influencing the rates of these two processes is essential for maximizing the useful lifespan of drugs and, therefore, effective disease control. For malaria parasites, artemisinin-based drugs are the frontline weapons in the fight against disease, but reports from the field of slower parasite clearance rates during drug treatment are generating concern that the useful lifespan of these drugs may be limited. Whether slower clearance rates represent true resistance, and how this provides a selective advantage for parasites is uncertain. Here, we show that Plasmodium chabaudi malaria parasites selected for resistance to artesunate (an artemisinin derivative) through a step-wise increase in drug dose evolved slower clearance rates extremely rapidly. In single infections, these slower clearance rates, similar to those seen in the field, provided fitness advantages to the parasite through increased overall density, recrudescence after treatment and increased transmission potential. In mixed infections, removal of susceptible parasites by drug treatment led to substantial increases in the densities and transmission potential of resistant parasites (competitive release). Our results demonstrate the double-edged sword for resistance management: in our initial selection experiments, no parasites survived aggressive chemotherapy, but after selection, the fitness advantage for resistant parasites was greatest at high drug doses. Aggressive treatment of mixed infections resulted in resistant parasites dominating the pool of gametocytes, without providing additional health benefits to hosts. Slower clearance rates can evolve rapidly and can provide a strong fitness advantage during drug treatment in both single and mixed strain

  20. Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection.

    Delić, Denis; Gailus, Nicole; Vohr, Hans-Werner; Dkhil, Mohamed; Al-Quraishy, Saleh; Wunderlich, Frank

    2010-12-01

    Testosterone has been previously shown to induce persistent susceptibility to Plasmodium chabaudi malaria in otherwise resistant female C57BL/6 mice. Here, we investigate as to whether this conversion coincides with permanent changes of hepatic gene expression profiles. Female mice aged 10-12 weeks were treated with testosterone for 3 weeks; then, testosterone treatment was discontinued for 12 weeks before challenging with 10⁶ P. chabaudi-infected erythrocytes. Hepatic gene expression was examined after 12 weeks of testosterone withdrawal and after subsequent infection with P. chabaudi at peak parasitemia, using Affymetrix microarrays with 22 ,690 probe sets representing 14, 000 genes. The expression of 54 genes was found to be permanently changed by testosterone, which remained changed during malaria infection. Most genes were involved in liver metabolism: the female-prevalent genes Cyp2b9, Cyp2b13, Cyp3a41, Cyp3a44, Fmo3, Sult2a2, Sult3a1, and BC014805 were repressed, while the male-prevalent genes Cyp2d9, Cyp7b1, Cyp4a10, Ugt2b1, Ugt2b38, Hsd3b5, and Slco1a1 were upregulated. Genes encoding different nuclear receptors were not persistently changed. Moreover, testosterone induced persistent upregulation of genes involved in hepatocellular carcinoma such as Lama3 and Nox4, whereas genes involved in immune response such as Ifnγ and Igk-C were significantly decreased. Our data provide evidence that testosterone is able to induce specific and robust long-term changes of gene expression profiles in the female mouse liver. In particular, those changes, which presumably indicate masculinized liver metabolism and impaired immune response, may be critical for the testosterone-induced persistent susceptibility of mice to P. chabaudi malaria. PMID:20844152

  1. Relevance of undetectably rare resistant malaria parasites in treatment failure: experimental evidence from Plasmodium chabaudi.

    Huijben, Silvie; Chan, Brian H K; Read, Andrew F

    2015-06-01

    Resistant malaria parasites are frequently found in mixed infections with drug-sensitive parasites. Particularly early in the evolutionary process, the frequency of these resistant mutants can be extremely low and below the level of molecular detection. We tested whether the rarity of resistance in infections impacted the health outcomes of treatment failure and the potential for onward transmission of resistance. Mixed infections of different ratios of resistant and susceptible Plasmodium chabaudi parasites were inoculated in laboratory mice and dynamics tracked during the course of infection using highly sensitive genotype-specific quantitative polymerase chain reaction (qPCR). Frequencies of resistant parasites ranged from 10% to 0.003% at the onset of treatment. We found that the rarer the resistant parasites were, the lower the likelihood of their onward transmission, but the worse the treatment failure was in terms of parasite numbers and disease severity. Strikingly, drug resistant parasites had the biggest impact on health outcomes when they were too rare to be detected by any molecular methods currently available for field samples. Indeed, in the field, these treatment failures would not even have been attributed to resistance. PMID:25940195

  2. Regulatory T cell induction during Plasmodium chabaudi infection modifies the clinical course of experimental autoimmune encephalomyelitis.

    Alessandro S Farias

    Full Text Available BACKGROUND: Experimental autoimmune encephalomyelitis (EAE is used as an animal model for human multiple sclerosis (MS, which is an inflammatory demyelinating autoimmune disease of the central nervous system characterized by activation of Th1 and/or Th17 cells. Human autoimmune diseases can be either exacerbated or suppressed by infectious agents. Recent studies have shown that regulatory T cells play a crucial role in the escape mechanism of Plasmodium spp. both in humans and in experimental models. These cells suppress the Th1 response against the parasite and prevent its elimination. Regulatory T cells have been largely associated with protection or amelioration in several autoimmune diseases, mainly by their capacity to suppress proinflammatory response. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we verified that CD4(+CD25(+ regulatory T cells (T regs generated during malaria infection (6 days after EAE induction interfere with the evolution of EAE. We observed a positive correlation between the reduction of EAE clinical symptoms and an increase of parasitemia levels. Suppression of the disease was also accompanied by a decrease in the expression of IL-17 and IFN-γ and increases in the expression of IL-10 and TGF-β1 relative to EAE control mice. The adoptive transfer of CD4(+CD25(+ cells from P. chabaudi-infected mice reduced the clinical evolution of EAE, confirming the role of these T regs. CONCLUSIONS/SIGNIFICANCE: These data corroborate previous findings showing that infections interfere with the prevalence and evolution of autoimmune diseases by inducing regulatory T cells, which regulate EAE in an apparently non-specific manner.

  3. Electron tomography characterization of hemoglobin uptake in Plasmodium chabaudi reveals a stage-dependent mechanism for food vacuole morphogenesis.

    Wendt, Camila; Rachid, Rachel; de Souza, Wanderley; Miranda, Kildare

    2016-05-01

    In the course of their intraerythrocytic development, malaria parasites incorporate and degrade massive amounts of the host cell cytoplasm. This mechanism is essential for parasite development and represents a physiological step used as target for many antimalarial drugs; nevertheless, the fine mechanisms underlying these processes in Plasmodium species are still under discussion. Here, we studied the events of hemoglobin uptake and hemozoin nucleation in the different stages of the intraerythrocytic cycle of the murine malaria parasite Plasmodium chabaudi using transmission electron tomography of cryofixed and freeze-substituted cells. The results showed that hemoglobin uptake in P. chabaudi starts at the early ring stage and is present in all developmental stages, including the schizont stage. Hemozoin nucleation occurs near the membrane of small food vacuoles. At the trophozoite stage, food vacuoles are found closely localized to cytostomal tubes and mitochondria, whereas in the schizont stage, we observed a large food vacuole located in the central portion of the parasite. Taken together, these results provide new insights into the mechanisms of hemoglobin uptake and degradation in rodent malaria parasites. PMID:26882843

  4. Phlebotomus (Paraphlebotomus) riouxi: a synonym of Phlebotomus chabaudi without any proven vectorial role in Tunisia and Algeria.

    Tabbabi, A; Rhim, A; Ghrab, J; Martin, O; Aoun, K; Bouratbine, A; Ready, P D

    2014-08-01

    Phlebotomus (Paraphlebotomus) riouxi Depaquit, Léger & Killick-Kendrick (Diptera: Psychodidae) was described as a typological species based on a few morphological characters distinguishing it from Phlebotomus (Paraphlebotomus) chabaudi Croset, Abonnenc & Rioux. The naming of P. riouxi coincided with its incrimination as a rural vector of Leishmania tropica Wright (junior synonym: Leishmania killicki Rioux, Lanotte & Pratlong) in Tataouine governorate, an arid region of southern Tunisia. The current report finds insufficient evidence to incriminate either phlebotomine sandfly as a vector of L. tropica in North Africa. Phlebotomus riouxi was found not to have the characteristics of a phylogenetic or biological species, and therefore it is synonymized with P. chabaudi. Both taxa were recorded together for the first time in Tunisia, in Tataouine, where three of 12 males showed intermediate morphology and both sexes of each taxon were not characterized by specific lineages of the nuclear gene elongation factor-1α or the mitochondrial gene cytochrome b, for which a long 3' terminal fragment is recommended for phlebotomine phylogenetics. This case study indicates that the eco-epidemiology of leishmaniasis should focus more on identifying key components of vectorial transmission that are susceptible to interventions for disease control, rather than on defining sibling species of vectors. PMID:25171607

  5. Yield and yield component of sweet potato as affected by Farmyard manure and Phosphorus application: in the case of Adami Tulu District, Central Rift Valley of Ethiopia

    Teshome-Abdissa M

    2012-08-01

    Full Text Available Sweet potato is among the most important tuberous root crops produced in the central rift valley of Ethiopia. However, the yield and yield components obtained in the area is far below its genetic potential. The major cause of low yield is the use of poor agronomic practices. Specifically, scarcity of information on appropriate rates of fertilizers to be applied for growing the crop is one. Therefore, a field experiment was conducted to investigate the effect of farmyard manure and phosphorus on the yield and yield components of the crop at Adami Tulu, central rift valley of Ethiopia during the 2010 main cropping season. The treatments consisted of five levels of FYM (0, 5, 10, 15, 20 t ha-1 and three levels of P (0, 90,180 kg P2O5 ha-1. It was laid out as a Randomized Complete Block Design in a factorial arrangement, and replicated three times. A sweet potato cultivar known in the area Belela was used for the study. The result indicated that the main effect of FYM significantly (P < 0.05 affected; total tuberous root yield, tuberous root dry weight, fresh total biomass and dry harvest index. However, the main effect of P had no any significant influence on all parameters studied. Moreover, the interaction effects of FYM and P significantly (P < 0.05 affected; marketable root yield, specific gravity and total dry biomass yield. Combined application of 20 t farmyard manure ha-1 and 180 kg ha-1 P2O5 resulted in production of highest marketable yield (32.56 t ha-1. The lowest marketable yield (8.8 t ha-1 was obtained at the application of 0 t ha-1 FYM combined with 180 kg P2O5 ha-1. Thus, most of the yield and yield estimate parameters were enhanced in response to the application of FYM. For the two commonly used sweet potato quality parameters (dry matter and specific gravity, dry matter was not significantly responsive to both FYM and P while the highest specific gravity (1.09 was obtained at the combined application of 10 t FYM ha-1 and 0 kg P2O5

  6. Unlike the synchronous Plasmodium falciparum and P. chabaudi infection, the P. berghei and P. yoelii asynchronous infections are not affected by melatonin

    Piero Bagnaresi

    2009-04-01

    Full Text Available Piero Bagnaresi1, Eduardo Alves1, Henrique Borges da Silva1, Sabrina Epiphanio2, Maria M Mota2, Célia RS Garcia11Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil; 2Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, PortugalAbstract: We have previously reported that Plasmodium chabaudi and P. falciparum sense the hormone melatonin and this could be responsible for the synchrony of malaria infection. In P. chabaudi and P. falciparum, melatonin induces calcium release from internal stores, and this response is abolished by U73122, a phospholipase C inhibitor, and luzindole, a melatoninreceptor competitive antagonist. Here we show that, in vitro, melatonin is not able to modulate cell cycle, nor to elicit an elevation in intracellular calcium concentration of the intraerythrocytic forms of P. berghei or P. yoelii, two rodent parasites that show an asynchrononous development in vivo. Interestingly, melatonin and its receptor do not seem to play a role during hepatic infection by P. berghei sporozoites either. These data strengthen the hypothesis that hostderived melatonin does not synchronize malaria infection caused by P. berghei and P. yoelii. Moreover, these data explain why infections by these parasites are asynchronous, contrary to what is observed in P. falciparum and P. chabaudi infections.Keywords: malaria, calcium, melatonin, cell cycle, rhythm, sporozoite

  7. Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses.

    Márcia M Medeiros

    Full Text Available It is postulated that accumulation of malaria-infected Red Blood Cells (iRBCs in the liver could be a parasitic escape mechanism against full destruction by the host immune system. Therefore, we evaluated the in vivo mechanism of this accumulation and its potential immunological consequences. A massive liver accumulation of P. c. chabaudi AS-iRBCs (Pc-iRBCs was observed by intravital microscopy along with an over expression of ICAM-1 on day 7 of the infection, as measured by qRT-PCR. Phenotypic changes were also observed in regulatory T cells (Tregs and dendritic cells (DCs that were isolated from infected livers, which indicate a functional role for Tregs in the regulation of the liver inflammatory immune response. In fact, the suppressive function of liver-Tregs was in vitro tested, which demonstrated the capacity of these cells to suppress naive T cell activation to the same extent as that observed for spleen-Tregs. On the other hand, it is already known that CD4+ T cells isolated from spleens of protozoan parasite-infected mice are refractory to proliferate in vivo. In our experiments, we observed a similar lack of in vitro proliferative capacity in liver CD4+ T cells that were isolated on day 7 of infection. It is also known that nitric oxide and IL-10 are partially involved in acute phase immunosuppression; we found high expression levels of IL-10 and iNOS mRNA in day 7-infected livers, which indicates a possible role for these molecules in the observed immune suppression. Taken together, these results indicate that malaria parasite accumulation within the liver could be an escape mechanism to avoid sterile immunity sponsored by a tolerogenic environment.

  8. Protective Vaccination against Blood-Stage Malaria of Plasmodium chabaudi: Differential Gene Expression in the Liver of Balb/c Mice toward the End of Crisis Phase

    Al-Quraishy, Saleh A.; Dkhil, Mohamed A.; Abdel-Baki, Abdel-Azeem A.; Delic, Denis; Wunderlich, Frank

    2016-01-01

    Protective vaccination induces self-healing of otherwise fatal blood-stage malaria of Plasmodium chabaudi in female Balb/c mice. To trace processes critically involved in self-healing, the liver, an effector against blood-stage malaria, is analyzed for possible changes of its transcriptome in vaccination-protected in comparison to non-protected mice toward the end of the crisis phase. Gene expression microarray analyses reveal that vaccination does not affect constitutive expression of mRNA and lincRNA. However, malaria induces significant (p 3-fold as compared to the corresponding constitutive expressions. Massive up-regulations, partly by >100-fold, are found for genes as RhD, Add2, Ank1, Ermap, and Slc4a, which encode proteins of erythrocytic surface membranes, and as Gata1 and Gfi1b, which encode transcription factors involved in erythrocytic development. Also, Cldn13 previously predicted to be expressed on erythroblast surfaces is up-regulated by >200-fold, though claudins are known as main constituents of tight junctions acting as paracellular barriers between epithelial cells. Other genes are up-regulated by 10-fold, which can be subgrouped in genes encoding proteins known to be involved in mitosis, in cell cycle regulation, and in DNA repair. Our data suggest that protective vaccination enables the liver to respond to P. chabaudi infections with accelerated regeneration and extramedullary erythropoiesis during crisis, which contributes to survival of otherwise lethal blood-stage malaria. PMID:27471498

  9. Resolution of acute malarial infections by T cell-dependent non-antibody-mediated mechanisms of immunity.

    Cavacini, L A; Parke, L A; Weidanz, W P

    1990-01-01

    While it is generally accepted that acute blood stage malarial infections are resolved through the actions of protective antibodies, we observed that resistance to acute infection with Plasmodium chabaudi adami was mediated by T cell-dependent cellular immune mechanisms independent of antibody. We now report that acute blood stage infections caused by three additional murine hemoprotozoan parasites, Plasmodium vinckei petteri, Plasmodium chabaudi chabaudi, and Babesia microti, appear to be co...

  10. Blood-stage malaria of Plasmodium chabaudi induces differential Tlr expression in the liver of susceptible and vaccination-protected Balb/c mice.

    Al-Quraishy, Saleh; Dkhil, Mohamed A; Alomar, Suliman; Abdel-Baki, Abdel Azeem S; Delic, Denis; Wunderlich, Frank; Araúzo-Bravo, Marcos J

    2016-05-01

    Protective vaccination induces self-healing of otherwise lethal blood-stage infections of Plasmodium chabaudi malaria. Here, we investigate mRNA expression patterns of all 12 members of the Toll-like receptor (Tlr) gene family in the liver, a major effector organ against blood-stage malaria, during lethal and vaccination-induced self-healing infections of P. chabaudi in female Balb/c mice. Gene expression microarrays reveal that all 12 Tlr genes are constitutively expressed, though at varying levels, and specifically respond to infection. Protective vaccination does not affect constitutive expression of any of the 12 Tlr genes but leads to differential expression (p < 0.05) of seven Tlrs (1, 2, 4, 7, 8, 12, and 13) in response to malaria. Quantitative PCR substantiates differential expression at p < 0.01. There is an increased expression of Tlr2 by approximately five-fold on day 1 post-infection (p.i.) and Tlr1 by approximately threefold on day 4 p.i.. At peak parasitemia on day 8 p.i., none of the 12 Tlrs display any differential expression. After peak parasitemia, towards the end of the crisis phase on day 11 p.i., expression of Tlrs 1, 4, and 12 is increased by approximately four-, two-, and three-fold, respectively, and that of Tlr7 is decreased by approximately two-fold. Collectively, our data suggest that though all 12 members of the Tlr gene family are specifically responsive to malaria in the liver, not only Tlr2 at the early stage of infection but also the Tlrs 1, 4, 7, and 12 towards the end of crisis phase are critical for vaccination-induced resolution and survival of otherwise lethal blood-stage malaria. PMID:26809341

  11. Caractérisation moléculaire et morphologique de deux espèces affines de Paraphlebotomus: Phlebotomus chabaudi Croset, Abonnenc & Rioux, 1970 et P. riouxi Depaquit, Killick-Kendrick & Léger, 1998 (Diptera : Psychodidae

    Bounamous A.

    2008-12-01

    Full Text Available La description en 1998 de Phlebotomus riouxi a posé le problème de la diagnose différentielle délicate de la femelle avec celle d’une espèce affine : P. chabaudi. Le rôle suspecté de P. chabaudi dans la transmission de Leishmania killicki dans certains foyers tunisiens nous a amené, à partir de 37 spécimens algériens et tunisiens, à effectuer la caractérisation moléculaire de ces deux taxons. Les séquences du gène du cytochrome b (cyt b de l’ADN mitochondrial individualisent clairement ces taxons et mettent en évidence une variabilité intraspécifique. L’analyse morphologique ne permet pas de différencier les femelles des deux espèces sur la base des caractères génitaux. Un caractère céphalique nouveau tenant à la présence de dents latérales antérieures sur l’armature pharyngienne de P. chabaudi, absentes chez P. riouxi, est proposé, mais un recours au typage moléculaire semble nécessaire pour une identification fiable.

  12. Treatment of Plasmodium chabaudi Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System

    Zoraima Neto

    2013-01-01

    Full Text Available Antimalarial drug resistance remains a major obstacle in malaria control. Evidence from Southeast Asia shows that resistance to artemisinin combination therapy (ACT is inevitable. Ethnopharmacological studies have confirmed the efficacy of curcumin against Plasmodium spp. Drug interaction assays between curcumin/piperine/chloroquine and curcumin/piperine/artemisinin combinations and the potential of drug treatment to interfere with the ubiquitin proteasome system (UPS were analyzed. In vivo efficacy of curcumin was studied in BALB/c mice infected with Plasmodium chabaudi clones resistant to chloroquine and artemisinin, and drug interactions were analyzed by isobolograms. Subtherapeutic doses of curcumin, chloroquine, and artemisinin were administered to mice, and mRNA was collected following treatment for RT-PCR analysis of genes encoding deubiquitylating enzymes (DUBs. Curcumin was found be nontoxic in BALB/c mice. The combination of curcumin/chloroquine/piperine reduced parasitemia to 37% seven days after treatment versus the control group’s 65%, and an additive interaction was revealed. Curcumin/piperine/artemisinin combination did not show a favorable drug interaction in this murine model of malaria. Treatment of mice with subtherapeutic doses of the drugs resulted in a transient increase in genes encoding DUBs indicating UPS interference. If curcumin is to join the arsenal of available antimalarial drugs, future studies exploring suitable drug partners would be of interest.

  13. Comment on "Self-organized criticality in living systems" by C Adami

    Newman, M E J; Sneppen, K; Tozier, W A; Fraser, Simon M.; Sneppen, Kim; Tozier, William A.

    1997-01-01

    Following extensive numerical experiments, it has been suggested that the evolution of competing computer programs in artificial life simulations shows signs of being a self-organized critical process. The primary evidence for this claim comes from the distribution of the lifetimes of species in the simulations, which appears to follow a power law. We argue that, for a number of reasons, it is unlikely that the system is in fact at a critical point and suggest an alternative explanation for the power-law lifetime distribution.

  14. Single Parents - Single Outcomes?

    2012-01-01

    This master thesis seeks to evaluate the social economic wellbeing of single parent households across eleven European countries. Starting with market income, taxes and transfers are incorporated to arrive at a disposable income figure. Effort is further made to include the value of in kind transfers, more specifically education and health care services. This results in an extended income concept, where redistribution both in cash and in kind is accounted for. Income figures for market inc...

  15. IL-10在Plasmodium yoelii 17XL和Plasmodium chabaud AS疟原虫混合感染宿主病理损伤中的作用研究%The Role of IL-10 on the Host Pathological Injury in DBA/2 Mice Mixed Infection with Plasmodium yoelii 17XL and Plasmodium chabaudi AS

    陈光; 曹雅明; 刘蕾; 蔡连顺; 毕胜; 苏菊香; 代月

    2013-01-01

    为探讨IL-10在致死型约氏疟原虫(Plasmodium yoelii 17XL,P.y17XL)和夏氏疟原虫(Plasmodium chabaudi AS,P.cAS)混合感染宿主病理损伤中的作用,用P.y17XL、P.cAS和P.y17XL+P.cAS分别感染DBA/2小鼠,计数红细胞感染率;感染后第3、5、8、10、12和19天分别尾静脉取血,肝素抗凝后短暂离心,采用高纯度DNA提取试剂盒抽提DNA,实时定量PCR检测虫负荷水平;感染后第0、1、3、5、8、10、12和15天制备脾细胞悬液,ELISA检测脾细胞培养上清中IL-10水平.实验结果发现,P.y17XL单独感染和混合感染小鼠IL-10水平在感染后第5天和第8天分别达峰值,随后开始下降至正常水平,小鼠虫血症均达中等水平,存活率100%;相比P.cAS感染小鼠IL-10在感染后第3天突然出现高水平升高并且维持时间较长;于感染后第8天达峰值,是同天P.y17XL单独感染和混合感染小鼠IL-10水平的2倍,虫血症水平较高,小鼠全部死亡.同时实时定量PCR结果发现,混合感染小鼠,于感染后3~ 12 d P.y17XL增殖占优势,而感染后15 ~ 19 d则P.cAS增殖处于优势状态.表明以IL-10为核心的免疫调节网络与疟疾感染过程中病理损伤密切相关.同时提示混合感染小鼠应答模式与P.y17XL感染小鼠的应答模式相同.%In order to investigate the role of IL-10 on the host pathological injury mixed infection with lethal Plasmodium yoelii 17XL (P. y17XL) and Plasmodium chabaudi AS (P. cAS) , DBA/2 mice were infected with P. y17XL, P. cAS, or P. y17XL + P. cAS respectively, and counted the infection rate of erythrocytes for each group of mice. Para-sitemia and mortality were monitored daily. Tail blood collected at different time points was anti-coagulated by heparin on day 3, 5, 8, 10, 12 and 19 post infection (PI) and cenlrifuged briefly for DNA extraction using a high pure blood genome DNA extraction kit, real-lime quantitative (RTQ) PCR for determining the level of parasite burden. On day 0, 1

  16. Single photon from a single trapped atom

    Full text: A quantum treatment of the interaction between atoms and light usually begins with the simplest model system: a two-level atom interacting with a monochromatic light wave. Here we demonstrate an elegant experimental realization of this system using an optically trapped single rubidium atom illuminated by resonant light pulses. We observe Rabi oscillations, and show that this system can be used as a highly efficient triggered source of single photons with a well-defined polarisation. In contrast to other sources based on neutral atoms and trapped ions, no optical cavity is required. We achieved a flux of single photons of about 104 s-1 at the detector, and observe complete antibunching. This source has potential applications for distributed atom-atom entanglement using single photons. (author)

  17. Single frequency intracavity SRO

    Abitan, Haim; Buchhave, Preben

    2000-01-01

    Summary form only given. A single resonance optical parametric oscillator (SRO) is inserted intracavity to a CW high power, single frequency, and ring Nd:YVO4 laser. We obtain a stable single frequency CW SRO with output at 1.7-1.9 μm (idler) and a resonating signal at 2.3-2.6 μm. The behavior of...

  18. Single Parent Adoption.

    Administration for Children, Youth, and Families (DHHS), Washington, DC.

    Presenting two views of the single-parent family, this pamphlet includes an article by two researchers (William Feigelman and Arnold R. Silverman) and a short statement by a single adoptive parent (Amanda Richards). The first paper summarizes earlier research on single-parent adoptions and discusses the results of a nationwide survey of 713…

  19. Single-Sex Classrooms

    Protheroe, Nancy

    2009-01-01

    Although single-sex education was once the norm in the U.S., the practice has largely been confined to private schools for more than a century. However, with the introduction of the final version of the U.S. Department of Education's so-called single-sex regulations in 2006, public schools were allowed greater flexibility to offer single-sex…

  20. HAKKÂRİLİ DEVLET ADAMI VE ÂLİMLER (ABBÂSÎLER DÖNEMİ) / White Pigeons of Aerie of Scholars From Hakkari (Abbasid Period)

    Gözütok, Şakir

    2012-01-01

    İslâm dünyasında, sahip oldukları ilmî ku-rumlarla veya âlimlerle şöhret bulmuş pek çok yerleşim merkezi bulunmaktadır. Her ne kadar tarihte kendilerinden sıkça söz edilen şehirler kadar olmasa da, bulunduğu bölge itibariyle kendisinden beklenenden daha çok ilme hiz-met vermiş ve âlim yetiştirmiş şehirlerden biri Hakkâri’dir. Burada söz konusu ettiğimiz âlimler Hakkârili olmakla beraber, bunların &cc...

  1. Attitudes Toward Single Parenthood

    Pećnik, Ninoslava; Raboteg-Šarić, Zora

    2010-01-01

    Changes in the family structure produce different social reactions, and the negative attitude of society towards single parent families can generate social vulnerability of this group. (The lack of) understanding of the environment influences not only the behaviour of other persons toward single parents and their children, but also their attitudes and personal experience of single parenthood. In order to improve the insight into the experience of new forms of family in our society, a survey o...

  2. Single Policy Study

    Kronsell, Annica; Manners, Ian James

    Single policy studies are the most common form of European Union (EU) research. Single policy studies are widely used to understand the role of the EU in a wide variety of sectors, together with their development over time, and often offer public policy prescriptions. This chapter discusses the...... relevance of single policy studies in EU research and give examples of how such research can be designed and carried out. The chapter reviews three examples of single policy studies using different methods based on EU environmental policy, the EU biofuels directive, and the EU Common Security and Defence...

  3. Single photon quantum cryptography

    Beveratos, Alexios; Brouri, Rosa; Gacoin, Thierry; Villing, André; Poizat, Jean-Philippe; Grangier, Philippe

    2002-01-01

    We report the full implementation of a quantum cryptography protocol using a stream of single photon pulses generated by a stable and efficient source operating at room temperature. The single photon pulses are emitted on demand by a single nitrogen-vacancy (NV) color center in a diamond nanocrystal. The quantum bit error rate is less that 4.6% and the secure bit rate is 9500 bits/s. The overall performances of our system reaches a domain where single photons have a measurable advantage over ...

  4. Single-atom nanoelectronics

    Prati, Enrico

    2013-01-01

    Single-Atom Nanoelectronics covers the fabrication of single-atom devices and related technology, as well as the relevant electronic equipment and the intriguing new phenomena related to single-atom and single-electron effects in quantum devices. It also covers the alternative approaches related to both silicon- and carbon-based technologies, also from the point of view of large-scale industrial production. The publication provides a comprehensive picture of the state of the art at the cutting edge and constitutes a milestone in the emerging field of beyond-CMOS technology. Although there are

  5. Single ventricle cardiac defect

    Single ventricle heart is defined as a rare cardiac abnormality with a single ventricle chamber involving diverse functional and physiological defects. Our case is of a ten month-old baby boy who died shortly after admission to the hospital due to vomiting and diarrhoea. Autopsy findings revealed cyanosis of finger nails and ears. Internal examination revealed; large heart, weighing 60 grams, single ventricle, without a septum and upper membranous part. Single ventricle is a rare pathology, hence, this paper aims to discuss this case from a medico-legal point of view. (author)

  6. Single Mothers "Do" Family

    Nelson, Margaret K.

    2006-01-01

    This paper explores how single mothers both incorporate others into family life (e.g., when they ask others to care for their children) and simultaneously "do families" in a manner that holds out a vision of a "traditional" family structure. Drawing on research with White, rural single mothers, the author explores the manner in which these women…

  7. Single Parent Adoptive Homes.

    Shireman, Joan F.

    1996-01-01

    Reviews research and reports on a longitudinal study of 15 single-parent adoptive homes over a 14-year period that demonstrated that these homes have the capacity to be successful adoptive placements. Identifies unique characteristics of single-parent adoptive homes, and notes the need for additional research to identify children for whom these…

  8. Single Nanoparticle Plasmonic Sensors

    Manish Sriram

    2015-10-01

    Full Text Available The adoption of plasmonic nanomaterials in optical sensors, coupled with the advances in detection techniques, has opened the way for biosensing with single plasmonic particles. Single nanoparticle sensors offer the potential to analyse biochemical interactions at a single-molecule level, thereby allowing us to capture even more information than ensemble measurements. We introduce the concepts behind single nanoparticle sensing and how the localised surface plasmon resonances of these nanoparticles are dependent upon their materials, shape and size. Then we outline the different synthetic approaches, like citrate reduction, seed-mediated and seedless growth, that enable the synthesis of gold and silver nanospheres, nanorods, nanostars, nanoprisms and other nanostructures with tunable sizes. Further, we go into the aspects related to purification and functionalisation of nanoparticles, prior to the fabrication of sensing surfaces. Finally, the recent developments in single nanoparticle detection, spectroscopy and sensing applications are discussed.

  9. Single-photon imaging

    Seitz, Peter

    2011-01-01

    The acquisition and interpretation of images is a central capability in almost all scientific and technological domains. In particular, the acquisition of electromagnetic radiation, in the form of visible light, UV, infrared, X-ray, etc. is of enormous practical importance. The ultimate sensitivity in electronic imaging is the detection of individual photons. With this book, the first comprehensive review of all aspects of single-photon electronic imaging has been created. Topics include theoretical basics, semiconductor fabrication, single-photon detection principles, imager design and applications of different spectral domains. Today, the solid-state fabrication capabilities for several types of image sensors has advanced to a point, where uncoooled single-photon electronic imaging will soon become a consumer product. This book is giving a specialist´s view from different domains to the forthcoming “single-photon imaging” revolution. The various aspects of single-photon imaging are treated by internati...

  10. Moving Single Atoms

    Stuart, Dustin

    2016-05-01

    Single neutral atoms are promising candidates for qubits, the fundamental unit of quantum information. We have built a set of optical tweezers for trapping and moving single Rubidium atoms. The tweezers are based on a far off-resonant dipole trapping laser focussed to a 1 μm spot with a single aspheric lens. We use a digital micromirror device (DMD) to generate dynamic holograms of the desired arrangement of traps. The DMD has a frame rate of 20 kHz which, when combined with fast algorithms, allows for rapid reconfiguration of the traps. We demonstrate trapping of up to 20 atoms in arbitrary arrangements, and the transport of a single-atom over a distance of 14 μm with continuous laser cooling, and 5 μm without. In the meantime, we are developing high-finesse fibre-tip cavities, which we plan to use to couple pairs of single atoms to form a quantum network.

  11. Single molecules and nanotechnology

    Vogel, Horst

    2007-01-01

    This book focuses on recent advances in the rapidly evolving field of single molecule research. These advances are of importance for the investigation of biopolymers and cellular biochemical reactions, and are essential to the development of quantitative biology. Written by leading experts in the field, the articles cover a broad range of topics, including: quantum photonics of organic dyes and inorganic nanoparticles their use in detecting properties of single molecules the monitoring of single molecule (enzymatic) reactions single protein (un)folding in nanometer-sized confined volumes the dynamics of molecular interactions in biological cells The book is written for advanced students and scientists who wish to survey the concepts, techniques and results of single molecule research and assess them for their own scientific activities.

  12. NCBI nr-aa BLAST: CBRC-MDOM-05-0039 [SEVENS

    Full Text Available CBRC-MDOM-05-0039 ref|XP_742542.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH81944.1| conserved hypothetical protein [Plasmodium chabaudi chabaudi] XP_742542.1 7e-68 58% ...

  13. NCBI nr-aa BLAST: CBRC-MDOM-05-0110 [SEVENS

    Full Text Available CBRC-MDOM-05-0110 ref|XP_742542.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH81944.1| conserved hypothetical protein [Plasmodium chabaudi chabaudi] XP_742542.1 2e-45 46% ...

  14. NCBI nr-aa BLAST: CBRC-MDOM-06-0010 [SEVENS

    Full Text Available CBRC-MDOM-06-0010 ref|XP_742542.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH81944.1| conserved hypothetical protein [Plasmodium chabaudi chabaudi] XP_742542.1 1e-41 37% ...

  15. Single-Arc IMRT?

    The idea of delivering intensity-modulated radiation therapy (IMRT) with a multileaf collimator in a continuous dynamic mode during a single rotation of the gantry has recently gained momentum both in research and industry. In this note we investigate the potential of this Single-Arc IMRT technique at a conceptual level. We consider the original theoretical example case from Brahme et al that got the field of IMRT started. Using analytical methods, we derive deliverable intensity 'landscapes' for Single-Arc as well as standard IMRT and Tomotherapy. We find that Tomotherapy provides the greatest flexibility in shaping intensity landscapes and that it allows one to deliver IMRT in a way that comes close to the ideal case in the transverse plane. Single-Arc and standard IMRT make compromises in different areas. Only in relatively simple cases that do not require substantial intensity modulation will Single-Arc be dosimetrically comparable to Tomotherapy. Compared with standard IMRT, Single-Arc could be dosimetrically superior in certain cases if one is willing to accept the spreading of low dose values over large volumes of normal tissue. In terms of treatment planning, Single-Arc poses a more challenging optimization problem than Tomotherapy or standard IMRT. We conclude that Single-Arc holds potential as an efficient IMRT technique especially for relatively simple cases. In very complex cases, Single-Arc may unduly compromise the quality of the dose distribution, if one tries to keep the treatment time below 2 min or so. As with all IMRT techniques, it is important to explore the tradeoff between plan quality and the efficiency of its delivery carefully for each individual case. (note)

  16. Single neuron computation

    McKenna, Thomas M; Zornetzer, Steven F

    1992-01-01

    This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real n

  17. Stresses of Single Parenting

    ... Text Size Email Print Share Stresses of Single Parenting Page Content Article Body What are some ways ... way. Check your local library for books on parenting. Local hospitals, the YMCA, and church groups often ...

  18. Single-photon imaging

    The acquisition and interpretation of images is a central capability in almost all scientific and technological domains. In particular, the acquisition of electromagnetic radiation, in the form of visible light, UV, infrared, X-ray, etc. is of enormous practical importance. The ultimate sensitivity in electronic imaging is the detection of individual photons. With this book, the first comprehensive review of all aspects of single-photon electronic imaging has been created. Topics include theoretical basics, semiconductor fabrication, single-photon detection principles, imager design and applications of different spectral domains. Today, the solid-state fabrication capabilities for several types of image sensors has advanced to a point, where uncooled single-photon electronic imaging will soon become a consumer product. This book is giving a specialist's view from different domains to the forthcoming ''single-photon imaging'' revolution. The various aspects of single-photon imaging are treated by internationally renowned, leading scientists and technologists who have all pioneered their respective fields. (orig.)

  19. Single Atom Plasmonic Switch

    Emboras, Alexandros; Ma, Ping; Haffner, Christian; Luisier, Mathieu; Hafner, Christian; Schimmel, Thomas; Leuthold, Juerg

    2015-01-01

    The atom sets an ultimate scaling limit to Moores law in the electronics industry. And while electronics research already explores atomic scales devices, photonics research still deals with devices at the micrometer scale. Here we demonstrate that photonic scaling-similar to electronics-is only limited by the atom. More precisely, we introduce an electrically controlled single atom plasmonic switch. The switch allows for fast and reproducible switching by means of the relocation of an individual or at most - a few atoms in a plasmonic cavity. Depending on the location of the atom either of two distinct plasmonic cavity resonance states are supported. Experimental results show reversible digital optical switching with an extinction ration of 10 dB and operation at room temperature with femtojoule (fJ) power consumption for a single switch operation. This demonstration of a CMOS compatible, integrated quantum device allowing to control photons at the single-atom level opens intriguing perspectives for a fully i...

  20. Single-plasmon interferences.

    Dheur, Marie-Christine; Devaux, Eloïse; Ebbesen, Thomas W; Baron, Alexandre; Rodier, Jean-Claude; Hugonin, Jean-Paul; Lalanne, Philippe; Greffet, Jean-Jacques; Messin, Gaétan; Marquier, François

    2016-03-01

    Surface plasmon polaritons are electromagnetic waves coupled to collective electron oscillations propagating along metal-dielectric interfaces, exhibiting a bosonic character. Recent experiments involving surface plasmons guided by wires or stripes allowed the reproduction of quantum optics effects, such as antibunching with a single surface plasmon state, coalescence with a two-plasmon state, conservation of squeezing, or entanglement through plasmonic channels. We report the first direct demonstration of the wave-particle duality for a single surface plasmon freely propagating along a planar metal-air interface. We develop a platform that enables two complementary experiments, one revealing the particle behavior of the single-plasmon state through antibunching, and the other one where the interferences prove its wave nature. This result opens up new ways to exploit quantum conversion effects between different bosonic species as shown here with photons and polaritons. PMID:26998521

  1. Single event mass spectrometry

    Conzemius, Robert J.

    1990-01-16

    A means and method for single event time of flight mass spectrometry for analysis of specimen materials. The method of the invention includes pulsing an ion source imposing at least one pulsed ion onto the specimen to produce a corresponding emission of at least one electrically charged particle. The emitted particle is then dissociated into a charged ion component and an uncharged neutral component. The ion and neutral components are then detected. The time of flight of the components are recorded and can be used to analyze the predecessor of the components, and therefore the specimen material. When more than one ion particle is emitted from the specimen per single ion impact, the single event time of flight mass spectrometer described here furnis This invention was made with Government support under Contract No. W-7405-ENG82 awarded by the Department of Energy. The Government has certain rights in the invention.

  2. Single Cell Oncogenesis

    Lu, Xin

    It is believed that cancer originates from a single cell that has gone through generations of evolution of genetic and epigenetic changes that associate with the hallmarks of cancer. In some cancers such as various types of leukemia, cancer is clonal. Yet in other cancers like glioblastoma (GBM), there is tremendous tumor heterogeneity that is likely to be caused by simultaneous evolution of multiple subclones within the same tissue. It is obvious that understanding how a single cell develops into a clonal tumor upon genetic alterations, at molecular and cellular levels, holds the key to the real appreciation of tumor etiology and ultimate solution for therapeutics. Surprisingly very little is known about the process of spontaneous tumorigenesis from single cells in human or vertebrate animal models. The main reason is the lack of technology to track the natural process of single cell changes from a homeostatic state to a progressively cancerous state. Recently, we developed a patented compound, photoactivatable (''caged'') tamoxifen analogue 4-OHC and associated technique called optochemogenetic switch (OCG switch), which we believe opens the opportunity to address this urgent biological as well as clinical question about cancer. We propose to combine OCG switch with genetically engineered mouse models of head and neck squamous cell carcinoma and high grade astrocytoma (including GBM) to study how single cells, when transformed through acute loss of tumor suppressor genes PTEN and TP53 and gain of oncogenic KRAS, can develop into tumor colonies with cellular and molecular heterogeneity in these tissues. The abstract is for my invited talk in session ``Beyond Darwin: Evolution in Single Cells'' 3/18/2016 11:15 AM.

  3. Single well techniques

    The single well technique method includes measurement of parameters of groundwater flow in saturated rock. For determination of filtration velocity the dilution of radioactive tracer is measured, for direction logging the collimeter is rotated in the probe linked with the compass. The limiting factor for measurement of high filtration velocities is the occurrence of turbulent flow. The single well technique is used in civil engineering projects, water works and subsurface drainage of liquid waste from disposal sites. The radioactive tracer method for logging the vertical fluid movement in bore-holes is broadly used in groundwater survey and exploitation. (author)

  4. Single gaze gestures

    Møllenbach, Emilie; Lilholm, Martin; Gail, Alastair; Hansen, John Paulin

    This paper examines gaze gestures and their applicability as a generic selection method for gaze-only controlled interfaces. The method explored here is the Single Gaze Gesture (SGG), i.e. gestures consisting of a single point-to-point eye movement. Horizontal and vertical, long and short SGGs were...... evaluated on two eye tracking devices (Tobii/QuickGlance (QG)). The main findings show that there is a significant difference in selection times between long and short SGGs, between vertical and horizontal selections, as well as between the different tracking systems....

  5. Single password authentication

    Küpçü, Alptekin; Acar, Tolga; Belenkiy, Mira

    2013-01-01

    Single Password Authentication Tolga Acar∗ Intel Corporation, Bellevue, WA, USA Mira Belenkiy Microsoft Research, Redmond, WA, USA Alptekin K up c u† Ko c University, _Istanbul, TURKEY May 11, 2013 Abstract Users frequently reuse their passwords when authenticating to various online services. Com-bined with the use of weak passwords or honeypot/phishing attacks, this brings high risks to th...

  6. Single port laparoscopic surgery

    Springborg, Henrik; Istre, Olav

    2012-01-01

    . Although the operations described are the first of their kind reported in Denmark, favorable operating times and very low complication rates are seen. It is the authors' opinion that in addition to being feasible for hysterectomy, single port laparoscopy may become the preferred method for many simple...

  7. Single Mother's Resource Handbook.

    Ferando, Annette; Newbert, David

    Funded under the Women's Educational Equity Act, the Assertiveness Training Program for Single Mothers was offered to mothers with children enrolled in the Omaha Head Start and Parent-Child Center Programs. The 16-week long program, providing a total of 40 hours of training, covered a wide range of topics in addition to the initial workshops on…

  8. Single photon and nonlocality

    Aurelien Drezet

    2007-03-01

    In a paper by Home and Agarwal [1], it is claimed that quantum nonlocality can be revealed in a simple interferometry experiment using only single particles. A critical analysis of the concept of hidden variable used by the authors of [1] shows that the reasoning is not correct.

  9. Single-atom spintronics

    Susan Z. HUA; Matthew R. SULLIVAN; Jason N. ARMSTRONG

    2006-01-01

    Recent work on magnetic quantum point contacts (QPCs) was discussed. Complete magnetoresistance loops across Co QPCs as small as a single atom was measured. The remarkable feature of these QPCs is the rapid oscillatory decay in magnetoresistance with the increase of contact size. In addition,stepwise or quantum magnetoresistance loops are observed,resulting from varying transmission probability of the available discrete conductance channels because the sample is cycled between the ferromagnetic (F) and antiferromagnetic (AF) aligned states. Quantized conductance combined with spin dependent transmission of electron waves gives rise to a multi-channel system with a quantum domain wall acting as a valve,i.e.,a quantum spin-valve. Behavior of a few-atom QPC is built on the behavior of a single-atom QPC and hence the summarization of results as 'single-atom spintronics'. An evolutionary trace of spin-dependent electron transmission from a single atom to bulk is provided,the requisite hallmarks of artefact-free magnetoresistance is established across a QPC - stepwise or quantum magnetoresistance loops and size dependent oscillatory magnetoresistance.

  10. Single-particle entanglement

    Can, M. Ali; Klyachko, Alexander; SHUMOVSKY, Alexander

    2004-01-01

    Using the approach to quantum entanglement based on the quantum fluctuations of observables, we show the existence of perfect entangled states of a single "spin-1" particle. We give physical examples related to the photons, condensed matter physics, and particle physics.

  11. Beware the single hit!

    2008-01-01

    The first time that single particle effects from cosmic rays on electronics were observed was in 1991, when one of the instruments aboard an ESA satellite broke down after only five days in space. On 5 July, the TS-LEA group will have completed the installation of monitors that will help to reduce similar dangerous effects on LHC electronics.

  12. From single molecule to single tubules

    Guo, Chin-Lin

    2012-02-01

    Biological systems often make decisions upon conformational changes and assembly of single molecules. In vivo, epithelial cells (such as the mammary gland cells) can respond to extracellular matrix (ECM) molecules, type I collagen (COL), and switch their morphology from a lobular lumen (100-200 micron) to a tubular lumen (1mm-1cm). However, how cells make such a morphogenetic decision through interactions with each other and with COL is unclear. Using a temporal control of cell-ECM interaction, we find that epithelial cells, in response to a fine-tuned percentage of type I collagen (COL) in ECM, develop various linear patterns. Remarkably, these patterns allow cells to self-assemble into a tubule of length ˜ 1cm and diameter ˜ 400 micron in the liquid phase (i.e., scaffold-free conditions). In contrast with conventional thought, the linear patterns arise through bi-directional transmission of traction force, but not through diffusible biochemical factors secreted by cells. In turn, the transmission of force evokes a long-range (˜ 600 micron) intercellular mechanical interaction. A feedback effect is encountered when the mechanical interaction modifies cell positioning and COL alignment. Micro-patterning experiments further reveal that such a feedback is a novel cell-number-dependent, rich-get-richer process, which allows cells to integrate mechanical interactions into long-range (> 1mm) linear coordination. Our results suggest a mechanism cells can use to form and coordinate long-range tubular patterns, independent of those controlled by diffusible biochemical factors, and provide a new strategy to engineer/regenerate epithelial organs using scaffold-free self-assembly methods.

  13. Towards single molecule switches.

    Zhang, Jia Lin; Zhong, Jian Qiang; Lin, Jia Dan; Hu, Wen Ping; Wu, Kai; Xu, Guo Qin; Wee, Andrew T S; Chen, Wei

    2015-05-21

    The concept of using single molecules as key building blocks for logic gates, diodes and transistors to perform basic functions of digital electronic devices at the molecular scale has been explored over the past decades. However, in addition to mimicking the basic functions of current silicon devices, molecules often possess unique properties that have no parallel in conventional materials and promise new hybrid devices with novel functions that cannot be achieved with equivalent solid-state devices. The most appealing example is the molecular switch. Over the past decade, molecular switches on surfaces have been intensely investigated. A variety of external stimuli such as light, electric field, temperature, tunneling electrons and even chemical stimulus have been used to activate these molecular switches between bistable or even multiple states by manipulating molecular conformations, dipole orientations, spin states, charge states and even chemical bond formation. The switching event can occur either on surfaces or in break junctions. The aim of this review is to highlight recent advances in molecular switches triggered by various external stimuli, as investigated by low-temperature scanning tunneling microscopy (LT-STM) and the break junction technique. We begin by presenting the molecular switches triggered by various external stimuli that do not provide single molecule selectivity, referred to as non-selective switching. Special focus is then given to selective single molecule switching realized using the LT-STM tip on surfaces. Single molecule switches operated by different mechanisms are reviewed and discussed. Finally, molecular switches embedded in self-assembled monolayers (SAMs) and single molecule junctions are addressed. PMID:25757483

  14. 75 FR 9247 - Single Family Mortgage Insurance Premium, Single Family

    2010-03-01

    ... URBAN DEVELOPMENT Single Family Mortgage Insurance Premium, Single Family AGENCY: Office of the Chief... the Single Family Premium Collection Subsystem-Upfront (SFPCS-U) to remit the upfront premium to... manage and process upfront single family mortgage insurance premium collections and corrections to...

  15. Single Capacitor Paradox

    Pankovic, Vladan

    2009-01-01

    In this work single capacitor paradox (a variation of the remarkable two capacitor paradox) is considered. Simply speaking in an ideal (without any electrical resistance and inductivity) electrical circuit with single charged capacitor and switch, by transition from initial, open state (switch in OFF position) in the final, closed state (switch in ON position), there is a total loss of the initial energy of the electrical field in condenser. Given energy loss can be simply explained without any dissipative effects (Joule heating or electromagnetic waves emission) by work of the electrical field by movement of the charge from one in the other plate of the capacitor. (Two capacitors paradox can be, obviously, explained in the analogous way.)

  16. Single mode thermal emission.

    Fohrmann, Lena Simone; Petrov, Alexander Yu; Lang, Slawa; Jalas, Dirk; Krauss, Thomas F; Eich, Manfred

    2015-10-19

    We report on the properties of a thermal emitter which radiates into a single mode waveguide. We show that the maximal power of thermal radiation into a propagating single mode is limited only by the temperature of the thermal emitter and does not depend on other parameters of the waveguide. Furthermore, we show that the power of the thermal emitter cannot be increased by resonant coupling. For a given temperature, the enhancement of the total emitted power is only possible if the number of excited modes is increased. Either a narrowband or a broadband thermal excitation of the mode is possible, depending on the properties of the emitter. We finally discuss an example system, namely a thermal source for silicon photonics. PMID:26480429

  17. Watching single molecules dance

    Mehta, Amit Dinesh

    Molecular motors convert chemical energy, from ATP hydrolysis or ion flow, into mechanical motion. A variety of increasingly precise mechanical probes have been developed to monitor and perturb these motors at the single molecule level. Several outstanding questions can be best approached at the single molecule level. These include: how far does a motor progress per energy quanta consumed? how does its reaction cycle respond to load? how many productive catalytic cycles can it undergo per diffusional encounter with its track? and what is the mechanical stiffness of a single molecule connection? A dual beam optical trap, in conjunction with in vitro ensemble motility assays, has been used to characterize two members of the myosin superfamily: muscle myosin II and chick brain myosin V. Both move the helical polymer actin, but myosin II acts in large ensembles to drive muscle contraction or cytokinesis, while myosin V acts in small numbers to transport vesicles. An optical trapping apparatus was rendered sufficiently precise to identify a myosin working stroke with 1nm or so, barring systematic errors such as those perhaps due to random protein orientations. This and other light microscopic motility assays were used to characterize myosin V: unlike myosin II this vesicle transport protein moves through many increments of travel while remaining strongly bound to a single actin filament. The step size, stall force, and travel distance of myosin V reveal a remarkably efficient motor capable of moving along a helical track for over a micrometer without significantly spiraling around it. Such properties are fully consistent with the putative role of an organelle transport motor, present in small numbers to maintain movement over long ranges relative to cellular size scales. The contrast between myosin II and myosin V resembles that between a human running on the moon and one walking on earth, where the former allows for faster motion when in larger ensembles but for less

  18. Single Bunch Monopole Instability

    Podobedov, B.; Heifets, S.; /SLAC

    2005-09-12

    We study single bunch stability with respect to monopole longitudinal oscillations in electron storage rings. Our analysis is different from the standard approach based on the linearized Vlasov equation. Rather, we reduce the full nonlinear Fokker-Planck equation to a Schroedinger-like equation which is subsequently analyzed by perturbation theory. We show that the Haissinski solution [3] may become unstable with respect to monopole oscillations and derive a stability criterion in terms of the ring impedance.

  19. Single-spin CCD

    Baart, T. A.; Shafiei, M.; Fujita, T.; Reichl, C.; Wegscheider, W.; Vandersypen, L. M. K.

    2016-04-01

    Spin-based electronics or spintronics relies on the ability to store, transport and manipulate electron spin polarization with great precision. In its ultimate limit, information is stored in the spin state of a single electron, at which point quantum information processing also becomes a possibility. Here, we demonstrate the manipulation, transport and readout of individual electron spins in a linear array of three semiconductor quantum dots. First, we demonstrate single-shot readout of three spins with fidelities of 97% on average, using an approach analogous to the operation of a charge-coupled device (CCD). Next, we perform site-selective control of the three spins, thereby writing the content of each pixel of this ‘single-spin charge-coupled device’. Finally, we show that shuttling an electron back and forth in the array hundreds of times, covering a cumulative distance of 80 μm, has negligible influence on its spin projection. Extrapolating these results to the case of much larger arrays points at a diverse range of potential applications, from quantum information to imaging and sensing.

  20. Single-polariton optomechanics.

    Restrepo, Juan; Ciuti, Cristiano; Favero, Ivan

    2014-01-10

    This Letter investigates a hybrid quantum system combining cavity quantum electrodynamics and optomechanics. The Hamiltonian problem of a photon mode coupled to a two-level atom via a Jaynes-Cummings coupling and to a mechanical mode via radiation pressure coupling is solved analytically. The atom-cavity polariton number operator commutes with the total Hamiltonian leading to an exact description in terms of tripartite atom-cavity-mechanics polarons. We demonstrate the possibility to obtain cooling of mechanical motion at the single-polariton level and describe the peculiar quantum statistics of phonons in such an unconventional regime. PMID:24483897

  1. Single Electrode Heat Effects

    Jacobsen, Torben; Broers, G. H. J.

    1977-01-01

    The heat evolution at a single irreversibly working electrode is treated onthe basis of the Brønsted heat principle. The resulting equation is analogous to the expression for the total heat evolution in a galvanic cellwith the exception that –DeltaS is substituted by the Peltier entropy, Delta......SP, of theelectrode reaction. eta is the overvoltage at the electrode. This equation is appliedto a high temperature carbonate fuel cell. It is shown that the Peltier entropyterm by far exceeds the heat production due to the irreversible losses, and thatthe main part of heat evolved at the cathode is...

  2. Single Nucleotide Polymorphism

    Børsting, Claus; Pereira, Vania; Andersen, Jeppe Dyrberg;

    2014-01-01

    Single nucleotide polymorphisms (SNPs) are the most frequent DNA sequence variations in the genome. They have been studied extensively in the last decade with various purposes in mind. In this chapter, we will discuss the advantages and disadvantages of using SNPs for human identification and...... briefly describe the methods that are preferred for SNP typing in forensic genetics. In addition, we will illustrate how SNPs can be used as investigative leads in the police investigation by discussing the use of ancestry informative markers and forensic DNA phenotyping. Modern DNA sequencing...

  3. [The single coronary artery].

    Godart, F; Berzin, B; Rihani, R; Pecheux, M; Dutoit, A

    1992-04-01

    Single coronary artery is a fairly rare entity which may nevertheless be found in 0.4 per cent of coronary arteriograms. The authors report 3 cases seen in 2 departments of cardiology. In each patient, despite the existence of definite cardiovascular risk factors, this distribution was a factor worsening coronary ischemia, leading to complete thrombosis in one case. Although most often a chance discovery, a review of the literature justifies the attribution to this anomaly of the onset of angina, infarction or even sudden death. PMID:1642437

  4. Single photons on demand

    Quantum cryptography and information processing are set to benefit from developments in novel light sources that can emit photons one by one. Quantum mechanics has gained a reputation for making counter-intuitive predictions. But we rarely get the chance to witness these effects directly because, being humans, we are simply too big. Take light, for example. The light sources that are familiar to us, such as those used in lighting and imaging or in CD and DVD players, are so huge that they emit billions and billions of photons. But what if there was a light source that emitted just one photon at a time? Over the past few years, new types of light source that are able to emit photons one by one have been emerging from laboratories around the world. Pulses of light composed of a single photon correspond to power flows in the femtowatt range - a million billion times less than that of a table lamp. The driving force behind the development of these single-photon sources is a range of novel applications that take advantage of the quantum nature of light. Quantum states of superposed and entangled photons could lead the way to guaranteed-secure communication, to information processing with unprecedented speed and efficiency, and to new schemes for quantum teleportation. (U.K.)

  5. Do Single Women Value Early Retirement more than Single Men?

    Danø, Anne Møller; Ejrnæs, Mette; Husted, Leif

    2004-01-01

    The focus of this paper is to analyse why a large fraction of single elderly people choose to retire early. A structural model directly based on the individual decision of labour supply is estimated on a sample of singles, where singles are defined as those who are living alone. We find that income and health are important determinants of the retirement decision. Furthermore, we find substantial gender differences in the retirement pattern. Healthy single women value retirement more than heal...

  6. Bioengineering single crystal growth.

    Wu, Ching-Hsuan; Park, Alexander; Joester, Derk

    2011-02-16

    Biomineralization is a "bottom-up" synthesis process that results in the formation of inorganic/organic nanocomposites with unrivaled control over structure, superior mechanical properties, adaptive response, and the capability of self-repair. While de novo design of such highly optimized materials may still be out of reach, engineering of the biosynthetic machinery may offer an alternative route to design advanced materials. Herein, we present an approach using micro-contact-printed lectins for patterning sea urchin embryo primary mesenchyme cells (PMCs) in vitro. We demonstrate not only that PMCs cultured on these substrates show attachment to wheat germ agglutinin and concanavalin A patterns but, more importantly, that the deposition and elongation of calcite spicules occurs cooperatively by multiple cells and in alignment with the printed pattern. This allows us to control the placement and orientation of smooth, cylindrical calcite single crystals where the crystallographic c-direction is parallel to the cylinder axis and the underlying line pattern. PMID:21265521

  7. Lanthanide single molecule magnets

    Tang, Jinkui

    2015-01-01

    This book begins by providing basic information on single-molecule magnets (SMMs), covering the magnetism of lanthanide, the characterization and relaxation dynamics of SMMs, and advanced means of studying lanthanide SMMs. It then systematically introduces lanthanide SMMs ranging from mononuclear and dinuclear to polynuclear complexes, classifying them and highlighting those SMMs with high barrier and blocking temperatures – an approach that provides some very valuable indicators for the structural features needed to optimize the contribution of an Ising type spin to a molecular magnet. The final chapter presents some of the newest developments in the lanthanide SMM field, such as the design of multifunctional and stimuli-responsive magnetic materials as well as the anchoring and organization of the SMMs on surfaces. In addition, the crystal structure and magnetic data are clearly presented with a wealth of illustrations in each chapter, helping newcomers and experts alike to better grasp ongoing trends and...

  8. Lanthanide single molecule magnets

    Tang, Jinkui; Zhang, Peng [Chinese Academy of Sciences, Changchun (China). Changchun Inst. of Applied Chemistry

    2015-10-01

    This book begins by providing basic information on single-molecule magnets (SMMs), covering the magnetism of lanthanide, the characterization and relaxation dynamics of SMMs and advanced means of studying lanthanide SMMs. It then systematically introduces lanthanide SMMs ranging from mononuclear and dinuclear to polynuclear complexes, classifying them and highlighting those SMMs with high barrier and blocking temperatures - an approach that provides some very valuable indicators for the structural features needed to optimize the contribution of an Ising type spin to a molecular magnet. The final chapter presents some of the newest developments in the lanthanide SMM field, such as the design of multifunctional and stimuli-responsive magnetic materials as well as the anchoring and organization of the SMMs on surfaces. In addition, the crystal structure and magnetic data are clearly presented with a wealth of illustrations in each chapter, helping newcomers and experts alike to better grasp ongoing trends and explore new directions.

  9. Isotropic Single Negative Metamaterials

    P. Protiva

    2008-09-01

    Full Text Available This paper presents the application of simple, and therefore cheap, planar resonators for building 3D isotropic metamaterials. These resonators are: a broadside-coupled split ring resonator with a magnetic response providing negative permeability; an electric dipole terminated by a loop inductor together with a double H-shaped resonator with an electric response providing negative permittivity. Two kinds of 3D isotropic single negative metamaterials are reported. The first material consists of unit cells in the form of a cube bearing on its faces six equal planar resonators with tetrahedral symmetry. In the second material, the planar resonators boxed into spherical plastic shells and randomly distributed in a hosting material compose a real 3D volumetric metamaterial with an isotropic response. In both cases the metamaterial shows negative permittivity or permeability, according to the type of resonators that are used. The experiments prove the isotropic behavior of the cells and of the metamaterial specimens.

  10. Single Sex Education. WEEA Digest.

    Pollard, Diane S.

    Title IX of the Educational Amendments of 1972 prohibits discrimination on the basis of sex in educational institutions that receive federal financial assistance. This digest focuses on the theme of single-sex education. Articles featured in this issue include: (1) "Single-Sex Education" (Diane S. Pollard); (2) "A Legal Framework for Single-Sex…

  11. Single atom spintronics

    Full text: Single atom spintronics (SASS) represents the ultimate physical limit in device miniaturization. SASS is characterized by ballistic electron transport, and is a fertile ground for exploring new phenomena. In addition to the 'stationary' (field independent) scattering centers that have a small and fixed contribution to total transmission probability of electron waves, domain walls constitute an additional and enhanced source of scattering in these magnetic quantum point contacts (QPCs), the latter being both field and spin-dependent. Through the measurement of complete hysteresis loops as a function of quantized conductance, we present definitive evidence of enhanced backscattering of electron waves by atomically sharp domain walls in QPCs formed between microfabricated thin films [1]. Since domain walls move in a magnetic field, the magnitude of spin-dependent scattering changes as the QPC is cycled along its hysteresis loop. For example, as shown in the inset in Fig. 1, from zero towards saturation in a given field direction, the resistance varies as the wall is being swept away, whereas the resistance is constant upon returning from saturation towards zero, since in this segment of the hysteresis loop no domain wall is present across the contact. The observed spin-valve like behavior is realized by control over wall width and shape anisotropy. This behavior also unmistakably sets itself apart from any mechanical artifacts; additionally, measurements made on single atom contacts provide an artifact-free environment [2]. Intuitively, it is simpler to organize the observed BMR data according to all possible transitions between different conductance plateaus, as shown by the dotted line in Fig. 1; the solid circles show experimental data for Co, which follows the predicted scheme. Requisite elements for the observation of the effect will be discussed in detail along with a review of state of research in this field. Practically, the challenge lies in making

  12. Single-nucleon experiments

    Deur, Alexandre

    2009-12-01

    We discuss the Jefferson Lab low momentum transfer data on moments of the nucleon spin structure functions $g_1$ and $g_2$ and on single charged pion electroproduction off polarized proton and polarized neutron. A wealth of data is now available, while more is being analyzed or expected to be taken in the upcoming years. Given the low momentum transfer selected by the experiments, these data can be compared to calculations from Chiral Perturbation theory, the effective theory of strong force that should describe it at low momentum transfer. The data on various moments and the respective calculations do not consistently agree. In particular, experimental data for higher moments disagree with the calculations.The absence of contribution from the $\\Delta$ resonance in the various observables was expected to facilitate the calculations and hence make the theory predictions either more robust or valid over a larger $Q^2$ range. Such expectation is verified only for the Bjorken sum, but not for other observables in which the $\\Delta$ is suppressed. Preliminary results on pion electroproduction off polarized nucleons are also presented and compared to phenomenological models for which contributions from different resonances are varied. Chiral Perturbation calculations of these observables, while not yet available, would be valuable and, together with these data, would provide an extensive test of the effective theory.

  13. Single Molecule Mechanochemistry

    Li, Shaowei; Zhang, Yanxing; Ho, Wilson; Wu, Ruqian; Ruqian Wu, Yanxing Zhang Team; Wilson Ho, Shaowei Li Team

    Mechanical forces can be used to trigger chemical reactions through bending and stretching of chemical bonds. Using the reciprocating movement of the tip of a scanning tunneling microscope (STM), mechanical energy can be provided to a single molecule sandwiched between the tip and substrate. When the mechanical pulse center was moved to the outer ring feature of a CO molecule, the reaction rate was significantly increased compared with bare Cu surface and over Au atoms. First, DFT calculations show that the presence of CO makes the Cu cavity more attractive toward H2 Second, H2 prefers the horizontal adsorption geometry in the Cu-Cu and Au-Cu cavities and no hybridization occurs between the antibonding states of H2 and states of Cu atoms. While H2 loses electrons from its bonding state in all three cavities, the filling of its anti-bonding state only occurs in the CO-Cu cavity. Both make the CO-Cu cavity much more effectively to chop the H2 molecule. Work was supported by the National Science Foundation Center for Chemical Innovation on Chemistry at the Space-Time Limit (CaSTL) under Grant No. CHE-1414466.

  14. The single entity option

    Traditionally, an owner hires an engineer to design a power facility or other project and then circulates the completed plans to several contractors for competitive bidding. Although there are many variations on this theme, there is an alternative method which is growing in popularity--the design-build concept. In this construction method, the same entity designs and constructs the facility. The design builder may be a single firm with both design and construction capacity in-house, or it may be a combination of two or more firms with complementary abilities. If there are multiple firms, they may be structured as a joint venture or with one of the firms prime and the others in a subcontracting role. The critical aspect is that the owner contracts with one entity which has the responsibility for both designing and constructing the facility. According to statistics compiled by the Design-Build Institute of America and F.W. Dodge DATALINE2, a national reporter of construction statistics and information, from April 1995 to April 1996 the number of design-build contracts increased 103 percent over the previous year. Of a total $212 billion construction market, about $37.2 billion--18 percent--was design build. The strongest growth was in the category of industrial--plants, refineries, factories and warehouses--in which the concept use was up more than 300 percent from the previous year

  15. Single-photon spectroscopy of a single molecule

    Rezus, Y L A; Lettow, R; Renn, A; Zumofen, G; Goetzinger, S; Sandoghdar, V

    2011-01-01

    Exploring the interaction of light and matter at the ultimate limit of single photons and single emitters is of great interest both from a fundamental point of view and for emerging applications in quantum engineering. However, the difficulty of generating single photons with specific wavelengths, bandwidths and brightness as well as the weak interaction probability of a single photon with an optical emitter pose a formidable challenge toward this goal. Here, we demonstrate a general approach based on the creation of single photons from a single emitter and their use for performing spectroscopy on a second emitter situated at a distance. Although we used organic molecules as emitters, our strategy is readily extendable to other material systems such as quantum dots and color centers. Our work ushers in a new line of experiments that provide access to the coherent and nonlinear couplings of few emitters and few propagating photons.

  16. From single-cell transcriptomics to single-molecule counting

    Islam, Saiful

    2013-01-01

    RNA-sequencing (RNA-seq) technology has been progressing so fast in the last few years and made it possible to perform transcriptome analysis at single-cell level that was even unimaginable a few years before. Nowadays, the importance of gene expression analysis at the single-cell level is increasingly appreciated for the study of complex heterogeneous tissue. Also, in order to solve the obscure and no consensus definition of cell types, the single-cell gene expression analysis ap...

  17. Monovar: single-nucleotide variant detection in single cells.

    Zafar, Hamim; Wang, Yong; Nakhleh, Luay; Navin, Nicholas; Chen, Ken

    2016-06-01

    Current variant callers are not suitable for single-cell DNA sequencing, as they do not account for allelic dropout, false-positive errors and coverage nonuniformity. We developed Monovar (https://bitbucket.org/hamimzafar/monovar), a statistical method for detecting and genotyping single-nucleotide variants in single-cell data. Monovar exhibited superior performance over standard algorithms on benchmarks and in identifying driver mutations and delineating clonal substructure in three different human tumor data sets. PMID:27088313

  18. Single-nanowire photoelectrochemistry

    Su, Yude; Liu, Chong; Brittman, Sarah; Tang, Jinyao; Fu, Anthony; Kornienko, Nikolay; Kong, Qiao; Yang, Peidong

    2016-07-01

    Photoelectrochemistry is one of several promising approaches for the realization of efficient solar-to-fuel conversion. Recent work has shown that photoelectrodes made of semiconductor nano-/microwire arrays can have better photoelectrochemical performance than their planar counterparts because of their unique properties, such as high surface area. Although considerable research effort has focused on studying wire arrays, the inhomogeneity in the geometry, doping, defects and catalyst loading present in such arrays can obscure the link between these properties and the photoelectrochemical performance of the wires, and correlating performance with the specific properties of individual wires is difficult because of ensemble averaging. Here, we show that a single-nanowire-based photoelectrode platform can be used to reliably probe the current–voltage (I–V) characteristics of individual nanowires. We find that the photovoltage output of ensemble array samples can be limited by poorly performing individual wires, which highlights the importance of improving nanowire homogeneity within an array. Furthermore, the platform allows the flux of photogenerated electrons to be quantified as a function of the lengths and diameters of individual nanowires, and we find that the flux over the entire nanowire surface (7–30 electrons nm–2 s–1) is significantly reduced as compared with that of a planar analogue (∼1,200 electrons nm–2 s–1). Such characterization of the photogenerated carrier flux at the semiconductor/electrolyte interface is essential for designing nanowire photoelectrodes that match the activity of their loaded electrocatalysts.

  19. Single-photon quadratic optomechanics

    Jie-Qiao Liao; Franco Nori

    2013-01-01

    We present exact analytical solutions to study the coherent interaction between a single photon and the mechanical motion of a membrane in quadratic optomechanics. We consider single-photon emission and scattering when the photon is initially inside the cavity and in the fields outside the cavity, respectively. Using our solutions, we calculate the single-photon emission and scattering spectra, and find relations between the spectral features and the system's inherent parameters, such as: the...

  20. Assessing Dimensions of Single Parenting: The Single Parenting Questionnaire.

    Stolberg, Arnold L.; Ullman, Ann J.

    1984-01-01

    Developed and validated an instrument that assesses five dimensions of single parenting: problem solving skills, parental warmth, discipline procedures, parent rules, enthusiasm for parenting and parent support systems. Results gave statistical support for the Single Parenting Questionnaire, suggesting it may be useful in both clinical and…

  1. Do single women value early retirement more than single men?

    Danø, Anne Møller; Ejrnæs, Mette; Husted, Leif

    2005-01-01

    and health are important determinants of the retirement decision. Furthermore, we find substantial gender differences in the retirement pattern. Healthy single women value retirement more than healthy single men and are willing to reduce their disposable income to 74% of their previous income while......The focus of this paper is to analyse why a large fraction of single elderly people choose to retire early. A structural model directly based on the individual decision of labour supply is estimated on a sample of singles, where singles are defined as those who are living alone. We find that income...... men are willing to reduce the income to 81%. Men's retirement decision is mainly influenced by income and health, whereas women's retirement decision is also affected by education and unemployment experience...

  2. Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice

    Hoeve, Marieke A.; Mylonas, Katie J; Fairlie-Clarke, Karen J; Mahajan, Simmi M; Allen, Judith E.; Graham, Andrea L

    2009-01-01

    Larvae of several common species of parasitic nematodes obligately migrate through, and often damage, host lungs. The larvae induce strong pulmonary Type 2 immune responses, including T-helper (Th)2 cells as well as alternatively activated macrophages (AAMphi) and associated chitinase and Fizz/resistin family members (ChaFFs), which are thought to promote tissue repair processes. Given the prevalence of systemic or lung-resident Type 1-inducing pathogens in geographical areas in which nematod...

  3. Rapid Response to Selection, Competitive Release and Increased Transmission Potential of Artesunate-Selected Plasmodium chabaudi Malaria Parasites

    Pollitt, Laura C.; Silvie Huijben; Sim, Derek G.; Salathé, Rahel M.; Jones, Matthew J.; Andrew F Read

    2014-01-01

    The evolution of drug resistance, a key challenge for our ability to treat and control infections, depends on two processes: de-novo resistance mutations, and the selection for and spread of resistant mutants within a population. Understanding the factors influencing the rates of these two processes is essential for maximizing the useful lifespan of drugs and, therefore, effective disease control. For malaria parasites, artemisinin-based drugs are the frontline weapons in the fight against di...

  4. Single-electron charging effects

    The status of our project on single-electron tunneling is at this point excellent. As outlined in our original proposal, a key goal in the development of this project was the demonstration and exploration of the microwave properties of single-electron systems. As discussed here, such work has to date been carried out

  5. Single-Gender Schools Scrutinized

    Zubrzycki, Jaclyn

    2012-01-01

    This article reports on a study on publicly run schools in the Republic of Trinidad and Tobago which has found that, while single-sex schools may benefit female students who prefer a single-sex environment, they are not inherently beneficial for boys or most girls. While the findings are based on data from one Caribbean nation, experts say they…

  6. Ramsey interference with single photons

    Clemmen, Stéphane; Ramelow, Sven; Gaeta, Alexander L

    2016-01-01

    Interferometry using discrete energy levels in nuclear, atomic or molecular systems is the foundation for a wide range of physical phenomena and enables powerful techniques such as nuclear magnetic resonance, electron spin resonance, Ramsey-based spectroscopy and laser/maser technology. It also plays a unique role in quantum information processing as qubits are realized as energy superposition states of single quantum systems. Here, we demonstrate quantum interference of different energy states of single quanta of light in full analogy to energy levels of atoms or nuclear spins and implement a Ramsey interferometer with single photons. We experimentally generate energy superposition states of a single photon and manipulate them with unitary transformations to realize arbitrary projective measurements, which allows for the realization a high-visibility single-photon Ramsey interferometer. Our approach opens the path for frequency-encoded photonic qubits in quantum information processing and quantum communicati...

  7. Single-shot readout of a single nuclear spin.

    Neumann, Philipp; Beck, Johannes; Steiner, Matthias; Rempp, Florian; Fedder, Helmut; Hemmer, Philip R; Wrachtrup, Jörg; Jelezko, Fedor

    2010-07-30

    Projective measurement of single electron and nuclear spins has evolved from a gedanken experiment to a problem relevant for applications in atomic-scale technologies like quantum computing. Although several approaches allow for detection of a spin of single atoms and molecules, multiple repetitions of the experiment that are usually required for achieving a detectable signal obscure the intrinsic quantum nature of the spin's behavior. We demonstrated single-shot, projective measurement of a single nuclear spin in diamond using a quantum nondemolition measurement scheme, which allows real-time observation of an individual nuclear spin's state in a room-temperature solid. Such an ideal measurement is crucial for realization of, for example, quantum error correction protocols in a quantum register. PMID:20595582

  8. Single perylene diimide dendrimers as single-photon sources

    Single-molecule fluorescence spectroscopy was performed on a number of perylene diimide multichromophores with different dendritic geometries, with the particular goal of characterizing their performance as single-photon sources at room temperature. The quality of the different perylene diimide-containing dendrimers as single-photon sources was evaluated by determining the Mandel parameter. Values similar to ones reported previously for perylene monoimide dendrimers were found. The different arrangements of the chromophores in the different dendrimers do not noticeably affect their efficiency as single-photon emitters. Due to the formation of oxygen-enhanced long dark states, anaerobic conditions are found to be the best for optimizing their performance, which is in contrast with the case for perylene monoimide containing dendrimers

  9. Single shot measurement of a silicon single electron transistor

    Hasko, D. G.; Ferrus, T.; Morrissey, Q. R.; Burge, S. R.; Freeman, E. J.; French, M. J.; Lam, A; Creswell, L.; Collier, R J; Williams, D.A.; Briggs, G. A. D.

    2008-01-01

    We have fabricated a custom cryogenic Complementary Metal-Oxide-Semiconductor (CMOS) integrated circuit that has a higher measurement bandwidth compared with conventional room temperature electronics. This allowed implementing single shot operations and observe the real-time evolution of the current of a phosphorous-doped silicon single electron transistor that was irradiated with a microwave pulse. Relaxation times up to 90 us are observed, suggesting the presence of well isolated electron e...

  10. Adverse selection without single crossing

    Schottmüller, Christoph

    2015-01-01

    The single-crossing assumption simplifies the analysis of screening models as local incentive compatibility becomes sufficient for global incentive compatibility. If single crossing is violated, global incentive compatibility constraints have to be taken into account. This paper studies monotone...... solutions in a screening model that allows a one-time violation of single crossing. The results show that local and non-local incentive constraints distort the solution in opposite directions. Therefore, the optimal decision might involve distortions above as well as below the first-best decision...

  11. Prospects of Single Tax Payers

    Tofan Ivan M.

    2014-01-01

    The article speaks about problem aspects of taxation, which were set by the state for the single tax administering due to permanent and system changes in the tax legislation. It shows the necessity of search for alternative methods of administering in the process of taxation of single tax payers by fiscal services. The goal of the article is the study of prospects of further taxation of entrepreneurs – single tax payers on the basis of analysis of conditions and principles created by the stat...

  12. 18. sajandi teise poole Šoti valgustusliku arhitektuuri ideedest, nende retseptsioonist Vene keisrikojas ning baltisaksa kultuuriruumis / Epi Tohvri

    Tohvri, Epi, 1970-

    2006-01-01

    Arhitektide Robert Adami (1728-1792), Charles Cameroni (1745-1812) ja William Hastie (Vassili Geste 1755-1832) loomingust. Šoti valgustusajastu olulisemad arhitektuuriideed. Robert Adami mõju Eestis mõisaarhitektuuris

  13. Single-Molecule DNA Analysis

    Efcavitch, J. William; Thompson, John F.

    2010-07-01

    The ability to detect single molecules of DNA or RNA has led to an extremely rich area of exploration of the single most important biomolecule in nature. In cases in which the nucleic acid molecules are tethered to a solid support, confined to a channel, or simply allowed to diffuse into a detection volume, novel techniques have been developed to manipulate the DNA and to examine properties such as structural dynamics and protein-DNA interactions. Beyond the analysis of the properties of nucleic acids themselves, single-molecule detection has enabled dramatic improvements in the throughput of DNA sequencing and holds promise for continuing progress. Both optical and nonoptical detection methods that use surfaces, nanopores, and zero-mode waveguides have been attempted, and one optically based instrument is already commercially available. The breadth of literature related to single-molecule DNA analysis is vast; this review focuses on a survey of efforts in molecular dynamics and nucleic acid sequencing.

  14. CERN Single Sign On Solution

    Ormancey, Emmanuel

    2008-01-01

    The need for Single Sign On has always been restricted by the absence of cross platform solutions: a single sign on working only on one platform or technology is nearly useless. The recent improvements in Web Services Federation (WS-Federation) standard enabling federation of identity, attribute, authentication and authorization information can now provide real extended Single Sign On solutions. Various solutions have been investigated at CERN and now, a Web SSO solution using some parts of WS-Federation technology is available. Using the Shibboleth Service Provider module for Apache hosted web sites and Microsoft ADFS as the identity provider linked to Active Directory user, users can now authenticate on any web application using a single authentication platform, providing identity, user information (building, phone...) as well as group membership enabling authorization possibilities. A typical scenario: a CERN user can now authenticate on a Linux/Apache website using Windows Integrated credentials, and his ...

  15. Single-electron thermal noise

    We report the observation of thermal noise in the motion of single electrons in an ultimately small dynamic random access memory (DRAM). The nanometer-scale transistors that compose the DRAM resolve the thermal noise in single-electron motion. A complete set of fundamental tests conducted on this single-electron thermal noise shows that the noise perfectly follows all the aspects predicted by statistical mechanics, which include the occupation probability, the law of equipartition, a detailed balance, and the law of kT/C. In addition, the counting statistics on the directional motion (i.e., the current) of the single-electron thermal noise indicate that the individual electron motion follows the Poisson process, as it does in shot noise. (papers)

  16. Single-employer pension plans

    Pension Benefit Guaranty Corporation — This spreadsheet lists the active single-employer pensions plans insured by PBGC. Plans are identified by name, employer identification number (EIN) and plan number...

  17. Future ISIS single crystal instruments

    The designs of two proposed new single crystal instruments for ISIS are described. The biological structures instrument DIBS will allow the study of large unit cell materials in reasonable counting times. HRED, the high resolution elastic diffractometer, will provide a single crystal instrument of resolution ΔQ/Q ∼ 10-3, increasing the available resolution for reciprocal space surveying by some 10-fold over that currently obtainable on SXD. (author)

  18. Single Page Web Applications Security

    Bogdan Beda

    2015-01-01

    With the constant spread of internet access, the world of software is constantly transforming product shapes into services delivered via web browsers. Modern next generation web applications change the way browsers and users interact with servers. A lot of word scale services have already been delivered by top companies as Single Page Applications. Moving services online poses a big attention towards data protection and web application security. Single Page Application are exposed to server-s...

  19. Single beam atom sorting machine

    We create two overlapping one-dimensional optical lattices using a single laser beam, a spatial light modulator and a high numerical aperture lens. These lattices have the potential to trap single atoms, and using the dynamic capabilities of the spatial light modulator may shift and sort atoms to a minimum atom-atom separation of 1.52 μm. We show how a simple feedback circuit can compensate for the spatial light modulator's intensity modulation

  20. Single-photon decision maker

    Makoto Naruse; Martin Berthel; Aurélien Drezet; Serge Huant; Masashi Aono; Hirokazu Hori; Song-Ju Kim

    2015-01-01

    Decision making is critical in our daily lives and for society in general and is finding evermore practical applications in information and communication technologies. Herein, we demonstrate experimentally that single photons can be used to make decisions in uncertain, dynamically changing environments. Using a nitrogen-vacancy in a nanodiamond as a single-photon source, we demonstrate the decision-making capability by solving the multi-armed bandit problem. This capability is directly and im...

  1. Single-photon Sagnac interferometer

    Bertocchi, Guillaume; Alibart, Olivier; Ostrowsky, Daniel Barry; Tanzilli, Sébastien; Baldi, Pascal

    2006-01-01

    We present the first experimental demonstration of the optical Sagnac effect at the single-photon level. Using a high quality guided-wave heralded single- photon source at 1550 nm and a fibre optics setup, we obtain an interference pattern with net visibilities up to (99.2 $\\pm$ 0.4%). On the basis of this high visibility and the compactness of the setup, the interest of such a system for fibre optics gyroscope is discussed.

  2. Analysis of single biological cells

    The extraction of elemental information from single cultured cells using nuclear microscopy is an area of great potential because it can provide both quantitative information on the uptake of elements by the cell, and also its elemental response to a wide variety of external stimuli. A recent technique based on nuclear physics technology enables the analysis of single cells down to the parts per million level to be achieved

  3. Efficient single molecule detection and single molecule photochemistry

    Affleck, R.L.; Ambrose, W.P.; Goodwin, P.M. [Los Alamos National Lab., NM (United States)] [and others

    1996-12-31

    Single molecule detection efficiencies greater than 90% in flowing sample streams can be attained by confining the sample to the center of the excitation laser beam and photobleaching the reagent stream immediately before it enters the detection flow cell. Photolysis of single molecules of B-Phycoerythrin dissolved in aqueous solution is observed as an abrupt cessation of the fluorescence from these molecules as they flow through {approximately}40 pl probe volume. An analysis of the survival times of individual molecules in the laser beams yields the photodestruction quantum yield of the molecule. Photon pair correlation measurements of the fluorescence detected from single B-PE molecules demonstrate that the molecule fluoresces from only one bilin chromophore at a time.

  4. Single-Photon Imaging and Efficient Coupling to Single Plasmons

    Celebrano, M; Kukura, P; Agio, M; Renn, A; Goetzinger, S; Sandoghdar, V

    2009-01-01

    We demonstrate strong coupling of single photons emitted by individual molecules at cryogenic and ambient conditions to individual nanoparticles. We provide images obtained both in transmission and reflection, where an efficiency greater than 55% was achieved in converting incident narrow-band photons to plasmon-polaritons (plasmons) of a silver nanoparticle. Our work paves the way to spectroscopy and microscopy of nano-objects with sub-shot noise beams of light and to triggered generation of single plasmons and electrons in a well-controlled manner.

  5. Control of Single-Stage Single-Phase PV inverter

    Ciobotaru, Mihai; Teodorescu, Remus; Blaabjerg, Frede

    2005-01-01

    In this paper the issue of control strategies for single-stage photovoltaic (PV) inverter is addressed. Two different current controllers have been implemented and an experimental comparison between them has been made. A complete control structure for the single-phase PV system is also presented....... The main elements of the PV control structure are: - a maximum power point tracker (MPPT) algorithm using the incremental conductance method; - a synchronization method using the phase-locked-loop (PLL), based on delay; - the input power control using the dc voltage controller and power feed...

  6. Deterministic Single-Phonon Source Triggered by a Single Photon

    Söllner, Immo; Midolo, Leonardo; Lodahl, Peter

    2016-06-01

    We propose a scheme that enables the deterministic generation of single phonons at gigahertz frequencies triggered by single photons in the near infrared. This process is mediated by a quantum dot embedded on chip in an optomechanical circuit, which allows for the simultaneous control of the relevant photonic and phononic frequencies. We devise new optomechanical circuit elements that constitute the necessary building blocks for the proposed scheme and are readily implementable within the current state-of-the-art of nanofabrication. This will open new avenues for implementing quantum functionalities based on phonons as an on-chip quantum bus.

  7. Deterministic Single-Phonon Source Triggered by a Single Photon

    Söllner, Immo; Lodahl, Peter

    2016-01-01

    We propose a scheme that enables the deterministic generation of single phonons at GHz frequencies triggered by single photons in the near infrared. This process is mediated by a quantum dot embedded on-chip in an opto-mechanical circuit, which allows for the simultaneous control of the relevant photonic and phononic frequencies. We devise new opto-mechanical circuit elements that constitute the necessary building blocks for the proposed scheme and are readily implementable within the current state-of-the-art of nano-fabrication. This will open new avenues for implementing quantum functionalities based on phonons as an on-chip quantum bus.

  8. Single particle tracking and single molecule energy transfer

    Bräuchle, Christoph; Michaelis, Jens

    2009-01-01

    Closing a gap in the literature, this handbook gathers all the information on single particle tracking and single molecule energy transfer. It covers all aspects of this hot and modern topic, from detecting virus entry to membrane diffusion, and from protein folding using spFRET to coupled dye systems, as well recent achievements in the field. Throughout, the first-class editors and top international authors present content of the highest quality, making this a must-have for physical chemists, spectroscopists, molecular physicists and biochemists.

  9. A Novel Single-Switch Single-Stage Electronic Ballast

    Lu-Hua Zhu; Xing-Bi Chen; Hong-Sheng Zhong

    2009-01-01

    A single-stage single-switch high- frequency electronic ballast topology is presented. The circuit topology is the integration of a buck power- factor-correction (PFC) converter and a class E resonant inverter with only one active power switch. The buck converter is operated in discontinuous conduction mode and at a fixed switching frequency, and constant duty cycle to achieve high power factor and it can be controlled easily. Detailed analysis of the operation and characteristics of the circuit is provided. Simulation results satisfy present standard require- ments.

  10. Single active finger IPMC microgripper

    This paper presents a new design for a single active finger ionic polymer metal composite (IPMC) microgripper. This design has one stationary finger and one actuating finger. The gripper is tested in comparison with a two fingered gripper (2FG) on its ability to perform pick and place operations. The grippers each use IPMC strips in three widths: 1.25 mm, 2.5 mm and 5.0 mm. The single fingered gripper shows success rates of 86.2%, 89.2%, and 75% respectively versus 78.5%, 93.9% and 75% for a 2FG. The single fingered gripper performance is nearly equivalent to that of a 2FG. Even though a single finger produces half the force, its ability to carry objects is as good as or better than a 2FG. In addition, the stationary finger is considerably stiffer than an active IPMC finger, which helps in positional accuracy. Using half the IPMC, the single fingered gripper is the economical choice. (paper)

  11. Single-photon decision maker

    Naruse, Makoto; Berthel, Martin; Drezet, Aurélien; Huant, Serge; Aono, Masashi; Hori, Hirokazu; Kim, Song-Ju

    2015-08-01

    Decision making is critical in our daily lives and for society in general and is finding evermore practical applications in information and communication technologies. Herein, we demonstrate experimentally that single photons can be used to make decisions in uncertain, dynamically changing environments. Using a nitrogen-vacancy in a nanodiamond as a single-photon source, we demonstrate the decision-making capability by solving the multi-armed bandit problem. This capability is directly and immediately associated with single-photon detection in the proposed architecture, leading to adequate and adaptive autonomous decision making. This study makes it possible to create systems that benefit from the quantum nature of light to perform practical and vital intelligent functions.

  12. Protein determination in single corns

    Determination of protein content in food materials is usually done by analyzing the nitrogen amount by wet chemical Kjeldahl method. An improved accuracy accompanied by smaller analyzing intervals can be achieved using nondestructive neutron activation. Analyses have been performed using 14 MeV neutrons to determine the content of N and P in single wheat corns. Irradiation parameters have been optimized to prevent serious radiation damage in grains. About 200 single corns have been investigated with total net weights ranging from 30 to 70 mg. The tested arrangement allows determination of nitrogen amount in a single corn down to 0.3 mg with an accuracy of better than 4 %. Mean nitrogen concentrations in the range from 9 to 19% per corn have been detected. (author) 5 refs.; 6 figs

  13. Polyamide 6 single polymer composites

    2009-08-01

    Full Text Available Combining the two basic techniques used for the preparation of single polymer composites (SPCs, hot compaction and film stacking, a polyamide 6 (PA 6 single polymer composite was manufactured. The starting materials were PA 6 high tenacity yarn (reinforcement and PA 6 film prepared via melt quenching (matrix, both expected to be the two principal polymorphic modifications of PA 6 and thus differing in their melting temperatures. The prepared single polymer composite is characterized by a layered structure and shows superior mechanical properties due to the good wetting – tensile modulus is improved by 200% and the ultimate tensile strength – by 300–400% as compared to the isotropic matrix film. Improvement of the interfacial adhesion via transreactions promoted by Sb2O3 as a catalyst was also undertaken.

  14. Single Page Web Applications Security

    Bogdan Beda

    2015-06-01

    Full Text Available With the constant spread of internet access, the world of software is constantly transforming product shapes into services delivered via web browsers. Modern next generation web applications change the way browsers and users interact with servers. A lot of word scale services have already been delivered by top companies as Single Page Applications. Moving services online poses a big attention towards data protection and web application security. Single Page Application are exposed to server-side web applications security in a new way. Also, having application logic being executed by untrusted client environment requires close attention on client application security. Single Page Applications are vulnerable to the same security threads as server-side web application thus not making them less secure. Defending techniques can be easily adapted to guard against hacker attacks.

  15. Nonlinear interaction between single photons.

    Guerreiro, T; Martin, A; Sanguinetti, B; Pelc, J S; Langrock, C; Fejer, M M; Gisin, N; Zbinden, H; Sangouard, N; Thew, R T

    2014-10-24

    Harnessing nonlinearities strong enough to allow single photons to interact with one another is not only a fascinating challenge but also central to numerous advanced applications in quantum information science. Here we report the nonlinear interaction between two single photons. Each photon is generated in independent parametric down-conversion sources. They are subsequently combined in a nonlinear waveguide where they are converted into a single photon of higher energy by the process of sum-frequency generation. Our approach results in the direct generation of photon triplets. More generally, it highlights the potential for quantum nonlinear optics with integrated devices and, as the photons are at telecom wavelengths, it opens the way towards novel applications in quantum communication such as device-independent quantum key distribution. PMID:25379916

  16. Transform-limited single photons from a single quantum dot

    Kuhlmann, Andreas V.; Prechtel, Jonathan H.; Houel, Julien; Ludwig, Arne; Reuter, Dirk; Wieck, Andreas D.; Warburton, Richard J.

    2015-09-01

    Developing a quantum photonics network requires a source of very-high-fidelity single photons. An outstanding challenge is to produce a transform-limited single-photon emitter to guarantee that single photons emitted far apart in the time domain are truly indistinguishable. This is particularly difficult in the solid-state as the complex environment is the source of noise over a wide bandwidth. A quantum dot is a robust, fast, bright and narrow-linewidth emitter of single photons; layer-by-layer growth and subsequent nano-fabrication allow the electronic and photonic states to be engineered. This represents a set of features not shared by any other emitter but transform-limited linewidths have been elusive. Here, we report transform-limited linewidths measured on second timescales, primarily on the neutral exciton but also on the charged exciton close to saturation. The key feature is control of the nuclear spins, which dominate the exciton dephasing via the Overhauser field.

  17. Single top prospects at LHC

    Cristinziani, Markus

    2008-01-01

    Single top quark processes are interesting as direct probes of the $Wtb$ vertex, and are also an important background in searches of the Higgs boson and beyond the standard model physics. Both ATLAS and CMS have performed studies with simulated data to estimate the expected uncertainty on the production cross section measurements of the three single top processes ($t$-channel, s-channel, $tW$ production) in the first years of LHC operations. Results in the different channels and for the two experiments are reported.

  18. Single Electron Transistor: Applications & Problems

    Om Kumar

    2010-12-01

    Full Text Available The goal of this paper is to review in brief the basic physics of nanoelectronic device single-electron transistor [SET] as well as prospective applications and problems in their applications. SET functioning based on the controllable transfer of single electrons between small conducting "islands". The device properties dominated by the quantum mechanical properties of matter and provide new characteristics coulomb oscillation, coulomb blockade that is helpful in a number of applications. SET is able to shear domain with silicon transistor in near future and enhance the device density. Recent research in SET gives new ideas which are going to revolutionize the random access memory and digital data storage technologies.

  19. Single particle-induced latchup

    This paper presents an up-to-date overview of the single-event latchup (SEL) hard failure mode encountered in electronic device applications involving heavy ion environment. This phenomenon is specific to CMOS technology. Single-event latchup is discussed after a short description of the effects induced by the interaction of a heavy ion with silicon. Understanding these effects is necessary to understand the different failures. This paper includes a description of the latchup phenomenon and the different triggering modes, reviews of models and hardening solutions, and finally presents new developments in simulation approaches

  20. Single crystalline mesoporous silicon nanowires

    Hochbaum, A.I.; Gargas, Daniel; Jeong Hwang, Yun; Yang, Peidong

    2009-08-04

    Herein we demonstrate a novel electroless etching synthesis of monolithic, single-crystalline, mesoporous silicon nanowire arrays with a high surface area and luminescent properties consistent with conventional porous silicon materials. These porous nanowires also retain the crystallographic orientation of the wafer from which they are etched. Electron microscopy and diffraction confirm their single-crystallinity and reveal the silicon surrounding the pores is as thin as several nanometers. Confocal fluorescence microscopy showed that the photoluminescence (PL) of these arrays emanate from the nanowires themselves, and their PL spectrum suggests that these arrays may be useful as photocatalytic substrates or active components of nanoscale optoelectronic devices.

  1. Single-molecule magnet engineering

    Pedersen, Kasper Steen; Bendix, Jesper; Clérac, Rodolphe

    2014-01-01

    to delicately tune, for instance, the properties of molecules that behave as "magnets", the so-called single-molecule magnets (SMMs). Although many interesting SMMs have been prepared by a more or less serendipitous approach, the assembly of predesigned, isolatable molecular entities into higher nuclearity...

  2. A Single-Pulse Integrator

    Miller, Arne

    1974-01-01

    A single-pulse integrator is described. It gives a relative measure of the integral of the output signal from a coil monitor on the Risø 10 MeV linear accelerator, and displays the value on a digital voltmeter. The reproduccibility is found to be better than ±1% for an accelerated pulse charge...

  3. Prospects of Single Tax Payers

    Tofan Ivan M.

    2014-03-01

    Full Text Available The article speaks about problem aspects of taxation, which were set by the state for the single tax administering due to permanent and system changes in the tax legislation. It shows the necessity of search for alternative methods of administering in the process of taxation of single tax payers by fiscal services. The goal of the article is the study of prospects of further taxation of entrepreneurs – single tax payers on the basis of analysis of conditions and principles created by the state for the business. The article used methods of system analysis, comparison, forecasting and modelling. It analyses the process of evolution of the simplified taxation system, accounting and reporting from the moment of its adoption until today. The article presents the structure of the quantitative composition of single tax payers depending on the selected groups. It marks out and characterises administrative and fiscal factors that do not facilitate further development of entrepreneurship in Ukraine. In the result of the conducted studies the article outlines problem aspects of organisation of taxation of the small business and offers specific and real ways of their overcoming or partial solution.

  4. Single liner shipping service design

    Plum, Christian Edinger Munk; Pisinger, David; Salazar-González, Juan-José;

    2014-01-01

    demand under commercially driven constraints. This paper introduces the Single Liner Shipping Service Design Problem. Arc-flow and path-flow models are presented using state-of-the-art elements from the wide literature on pickup and delivery problems. A Branch-and-Cut-and-Price algorithm is proposed...

  5. Single mode glass fiber welding

    Nelson, M. D.; Fearnehough, H. T.; Goldstein, R.; Goss, W. C.

    1979-01-01

    The electric-arc welding of commercially available single-mode optical fiber has been demonstrated. A mean transmission of 92% and a maximum transmission of 98% are reported for welds of fiber waveguide of 4.5 microns core diameter.

  6. CERN single sign on solution

    Ormancey, E [System Architect, CERN IT/IS CERN, Route de Meyrin, CH-1211 Geneva 23 (Switzerland)], E-mail: Emmanuel.Ormancey@cern.ch

    2008-07-15

    The need for Single Sign On has always been restricted by the absence of cross platform solutions: a single sign on working only on one platform or technology is nearly useless. The recent improvements in Web Services Federation (WS-Federation) standard enabling federation of identity, attribute, authentication and authorization information can now provide real extended Single Sign On solutions. Various solutions have been investigated at CERN and now, a Web SSO solution using some parts of WS-Federation technology is available. Using the Shibboleth Service Provider module for Apache hosted web sites and Microsoft ADFS as the identity provider linked to Active Directory user, users can now authenticate on any web application using a single authentication platform, providing identity, user information (building, phone...) as well as group membership enabling authorization possibilities. A typical scenario: a CERN user can now authenticate on a Linux/Apache website using Windows Integrated credentials, and his Active Directory group membership can be checked before allowing access to a specific web page.

  7. CERN single sign on solution

    Ormancey, E.

    2008-07-01

    The need for Single Sign On has always been restricted by the absence of cross platform solutions: a single sign on working only on one platform or technology is nearly useless. The recent improvements in Web Services Federation (WS-Federation) standard enabling federation of identity, attribute, authentication and authorization information can now provide real extended Single Sign On solutions. Various solutions have been investigated at CERN and now, a Web SSO solution using some parts of WS-Federation technology is available. Using the Shibboleth Service Provider module for Apache hosted web sites and Microsoft ADFS as the identity provider linked to Active Directory user, users can now authenticate on any web application using a single authentication platform, providing identity, user information (building, phone...) as well as group membership enabling authorization possibilities. A typical scenario: a CERN user can now authenticate on a Linux/Apache website using Windows Integrated credentials, and his Active Directory group membership can be checked before allowing access to a specific web page.

  8. CERN single sign on solution

    The need for Single Sign On has always been restricted by the absence of cross platform solutions: a single sign on working only on one platform or technology is nearly useless. The recent improvements in Web Services Federation (WS-Federation) standard enabling federation of identity, attribute, authentication and authorization information can now provide real extended Single Sign On solutions. Various solutions have been investigated at CERN and now, a Web SSO solution using some parts of WS-Federation technology is available. Using the Shibboleth Service Provider module for Apache hosted web sites and Microsoft ADFS as the identity provider linked to Active Directory user, users can now authenticate on any web application using a single authentication platform, providing identity, user information (building, phone...) as well as group membership enabling authorization possibilities. A typical scenario: a CERN user can now authenticate on a Linux/Apache website using Windows Integrated credentials, and his Active Directory group membership can be checked before allowing access to a specific web page

  9. Handbook for Prospective Single Parents.

    Marindin, Hope

    This handbook for prospective single adoptive parents provides information on locating and adopting a child, necessary clothing and supplies for children of various ages, health and day care arrangements, expenses incurred after adoption, various financial benefits and subsidies available to the adoptive parent, and legal and financial provisions…

  10. SINGLE FIBER TESTING VIA FAVIMAT

    Cotton fiber is usually tested in bulk form utilizing a mass or beard of fibers to be presented to a test instrument for measurement. There are many reasons for this, not the least of which is that handling single cotton fibers is tedious and time consuming. Cotton breeders are being pushed to mak...

  11. Single port Billroth I gastrectomy

    Jeremy R Huddy

    2013-01-01

    Full Text Available Introduction: Experience has allowed increasingly complex procedures to be undertaken by single port surgery. We describe a technique for single port Billroth I gastrectomy with a hand-sewn intracorporeal anastomosis in the resection of a benign tumour diagnosed incidentally on a background of cholelithiasis. Materials and Methods: Single port Billroth I gastrectomy and cholecystectomy was performed using a transumbilical quadport. Flexible tipped camera and straight conventional instruments were used throughout the procedure. The stomach was mobilised including a limited lymph node dissection and resection margins in the proximal antrum and duodenum were divided with a flexible tipped laparoscopic stapler. The lesser curve was reconstructed and an intracorporal hand sewn two layer end-to-end anastomosis was performed using unidirectional barbed sutures. Intraoperative endoscopy confirmed the anastomosis to be patent without leak. Results: Enteral feed was started on the day of surgery, increasing to a full diet by day 6. Analgesic requirements were a patient-controlled analgesia morphine pump for 4 postoperative days and paracetamol for 6 days. There were no postoperative complications and the patient was discharged on the eighth day. Histology confirmed gastric submucosal lipoma. Discussion: As technology improves more complex procedures are possible by single port laparoscopic surgery. In this case, flexible tipped cameras and unidirectional barbed sutures have facilitated an intracorporal hand-sewn two layer end-to-end anastomosis. Experience will allow such techniques to become mainstream.

  12. Single Electron Transistor: Applications & Problems

    Om Kumar

    2010-12-01

    Full Text Available The goal of this paper is to review in brief the basic physics of nano electronic device single-electron transistor [SET] as well as prospective applications and problems in their applications. SET functioning based on the controllable transfer of single electrons between small conducting "islands". The device properties dominated by the quantum mechanical properties of matter and provide new characteristics coulomb oscillation, coulomb blockade that is helpful in a number of applications. SET is able to shear domain with silicon transistor in near future and enhance the device density. Recent research in SET gives new ideas which are going to revolutionize the random access memory and digital data storage technologies.

  13. Invariance for Single Curved Manifold

    Castro, Pedro Machado Manhaes de

    2012-08-01

    Recently, it has been shown that, for Lambert illumination model, solely scenes composed by developable objects with a very particular albedo distribution produce an (2D) image with isolines that are (almost) invariant to light direction change. In this work, we provide and investigate a more general framework, and we show that, in general, the requirement for such in variances is quite strong, and is related to the differential geometry of the objects. More precisely, it is proved that single curved manifolds, i.e., manifolds such that at each point there is at most one principal curvature direction, produce invariant is surfaces for a certain relevant family of energy functions. In the three-dimensional case, the associated energy function corresponds to the classical Lambert illumination model with albedo. This result is also extended for finite-dimensional scenes composed by single curved objects. © 2012 IEEE.

  14. Femtosecond single-electron diffraction

    S. Lahme

    2014-05-01

    Full Text Available Ultrafast electron diffraction allows the tracking of atomic motion in real time, but space charge effects within dense electron packets are a problem for temporal resolution. Here, we report on time-resolved pump-probe diffraction using femtosecond single-electron pulses that are free from intra-pulse Coulomb interactions over the entire trajectory from the source to the detector. Sufficient average electron current is achieved at repetition rates of hundreds of kHz. Thermal load on the sample is avoided by minimizing the pump-probe area and by maximizing heat diffusion. Time-resolved diffraction from fibrous graphite polycrystals reveals coherent acoustic phonons in a nanometer-thick grain ensemble with a signal-to-noise level comparable to conventional multi-electron experiments. These results demonstrate the feasibility of pump-probe diffraction in the single-electron regime, where simulations indicate compressibility of the pulses down to few-femtosecond and attosecond duration.

  15. Teleportation using squeezed single photons

    Branczyk, Agata M.; Ralph, T. C.

    2008-01-01

    We present an analysis of squeezed single photon states as a resource for teleportation of coherent state qubits and propose proof-of-principle experiments for the demonstration of coherent state teleportation and entanglement swapping. We include an analysis of the squeezed vacuum as a simpler approximation to small-amplitude cat states. We also investigate the effects of imperfect sources and inefficient detection on the proposed experiments.

  16. Single-electron heat diode

    Ruokola, Tomi; Ojanen, Teemu

    2011-01-01

    We introduce a new functional nanoscale device, a single-electron heat diode, consisting of two quantum dots or metallic islands coupled to electronic reservoirs by tunnel contacts. Electron transport through the system is forbidden but the capacitive coupling between the two dots allows electronic fluctuations to transmit heat between the reservoirs. When the reservoir temperatures are biased in the forward direction, heat flow is enabled by a four-step sequential tunneling cycle, while in t...

  17. Single and Coupled Nanobeam Cavities

    Ivinskaya, Aliaksandra; Lavrinenko, Andrei; Shyroki, Dzmitry M.; A. Sukhorukov, Andrey

    This book collects chapters on different theoretical and experimental aspects of photonics crystals for Nanophotonics applications. It is divided in two parts - a theoretical section and an experimental and applicative section. The first part includes chapters developing several numerical methods...... for analysis and design of photonic crystal devices, such as 2D ring resonators for filters, single and coupled nanobeam cavities, birefringence in photonic crystal cavities, threshold analysis in photonic crystal lasers, gap solitons in photonic crystals, novel photonic atolls, dynamic...

  18. Single mode levitation and translation

    Barmatz, Martin B. (Inventor); Allen, James L. (Inventor)

    1988-01-01

    A single frequency resonance mode is applied by a transducer to acoustically levitate an object within a chamber. This process allows smooth movement of the object and suppression of unwanted levitation modes that would urge the object to a different levitation position. A plunger forms one end of the chamber, and the frequency changes as the plunger moves. Acoustic energy is applied to opposite sides of the chamber, with the acoustic energy on opposite sides being substantially 180 degrees out of phase.

  19. Single electron relativistic clock interferometer

    Bushev, Pavel; Sholokhov, Dmitry; Kukharchyk, Nadezhda; Zych, Magdalena

    2016-01-01

    Although time is one of the fundamental notions in physics, it does not have a unique description. In quantum theory time is a parameter ordering the succession of the probability amplitudes of a quantum system, while according to relativity theory each system experiences in general a different proper time, depending on the system's world line, due to time to time dilation. It is therefore of fundamental interest to test the notion of time in the regime where both quantum and relativistic effects play a role, for example, when different amplitudes of a single quantum clock experience different magnitudes of time dilation. Here we propose a realization of such an experiment with a single electron in a Penning trap. The clock can be implemented in the electronic spin precession and its time dilation then depends on the radial (cyclotron) state of the electron. We show that coherent manipulation and detection of the electron can be achieved already with present day technology. A single electron in a Penning trap...

  20. Adoption and Single Parents: A Review.

    Groze, Vic

    1991-01-01

    Examines the literature about people who choose to become single adoptive parents. Reviews the demographic and personal characteristics of single parents who adopt, and summarizes the experiences of single parents with the children they adopt. Calls for further research on single parents who adopt special needs children. (GH)

  1. Single Molecule Applications of Quantum Dots

    Rasmussen, Thomas Elmelund; Jauffred, Liselotte; Brewer, Jonathan R.;

    2013-01-01

    tracking single lipids in lipid bilayers, 4) two-photon fluorescence correlation spectroscopy of QDs and 5) optical trapping and excitation of single QDs. In all of these applications, the focus is on the single particle sensitivity level of QDs. The high applicability of QDs in live cell imaging...... experiments held together with the prospects in localization microscopy and single molecule manipulation experiments gave QDs a promising future in single molecule research....

  2. Experimental techniques for single cell and single molecule biomechanics

    Lim, C.T. [Nano Biomechanics Laboratory, Division of Bioengineering and Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576 (Singapore)]. E-mail: ctlim@nus.edu.sg; Zhou, E.H. [Nano Biomechanics Laboratory, Division of Bioengineering and Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576 (Singapore); Li, A. [Nano Biomechanics Laboratory, Division of Bioengineering and Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576 (Singapore); Vedula, S.R.K. [Nano Biomechanics Laboratory, Division of Bioengineering and Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576 (Singapore); Fu, H.X. [Nano Biomechanics Laboratory, Division of Bioengineering and Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576 (Singapore)

    2006-09-15

    Stresses and strains that act on the human body can arise either from external physical forces or internal physiological environmental conditions. These biophysical interactions can occur not only at the musculoskeletal but also cellular and molecular levels and can determine the health and function of the human body. Here, we seek to investigate the structure-property-function relationship of cells and biomolecules so as to understand their important physiological functions as well as establish possible connections to human diseases. With the recent advancements in cell and molecular biology, biophysics and nanotechnology, several innovative and state-of-the-art experimental techniques and equipment have been developed to probe the structural and mechanical properties of biostructures from the micro- down to picoscale. Some of these experimental techniques include the optical or laser trap method, micropipette aspiration, step-pressure technique, atomic force microscopy and molecular force spectroscopy. In this article, we will review the basic principles and usage of these techniques to conduct single cell and single molecule biomechanics research.

  3. Experimental techniques for single cell and single molecule biomechanics

    Stresses and strains that act on the human body can arise either from external physical forces or internal physiological environmental conditions. These biophysical interactions can occur not only at the musculoskeletal but also cellular and molecular levels and can determine the health and function of the human body. Here, we seek to investigate the structure-property-function relationship of cells and biomolecules so as to understand their important physiological functions as well as establish possible connections to human diseases. With the recent advancements in cell and molecular biology, biophysics and nanotechnology, several innovative and state-of-the-art experimental techniques and equipment have been developed to probe the structural and mechanical properties of biostructures from the micro- down to picoscale. Some of these experimental techniques include the optical or laser trap method, micropipette aspiration, step-pressure technique, atomic force microscopy and molecular force spectroscopy. In this article, we will review the basic principles and usage of these techniques to conduct single cell and single molecule biomechanics research

  4. Single ion cavity QED experiments

    Full text: We have set up a spherical Paul trap for a storing a single Ca+ ion placed in the center of a high finesse near confocal resonator. We report on experiments demonstrating the coupling of the narrow S1/2-D5/2 transition to the cavity internal light field. Due to the coupling, the ion acts as sensitive probe for the cavity internal field. We are able to map the field distribution by measuring the excitation probability. Scanning the cavity over the resonance imprints a Doppler frequency shift on the cavity field which leads to a spectral shift and a asymmetric broadening of the S-D transition. (author)

  5. Investigation of single event latchup

    Radiation effects on avionics microelectronics are important reliability issues for many space applications. In particular, single-event latchup (SEL) phenomenon is a major threat to CMOS integrated circuits in space systems. To effectively circumvent the failure, it is important to know the behavior of such devices during latchup. In this paper, the mechanisms for SEL in CMOS devices are investigated. Several microelectronic devices used in avionics are tested using heavy ion beams, pulsed laser and 252Cf source. Based on the SEL test results, SEL-hardening and monitoring methods for preventing SEL from the systems design level are proposed. (authors)

  6. SINGLE HEATER TEST FINAL REPORT

    The Single Heater Test is the first of the in-situ thermal tests conducted by the U.S. Department of Energy as part of its program of characterizing Yucca Mountain in Nevada as the potential site for a proposed deep geologic repository for the disposal of spent nuclear fuel and high-level nuclear waste. The Site Characterization Plan (DOE 1988) contained an extensive plan of in-situ thermal tests aimed at understanding specific aspects of the response of the local rock-mass around the potential repository to the heat from the radioactive decay of the emplaced waste. With the refocusing of the Site Characterization Plan by the ''Civilian Radioactive Waste Management Program Plan'' (DOE 1994), a consolidated thermal testing program emerged by 1995 as documented in the reports ''In-Situ Thermal Testing Program Strategy'' (DOE 1995) and ''Updated In-Situ Thermal Testing Program Strategy'' (CRWMS M and O 1997a). The concept of the Single Heater Test took shape in the summer of 1995 and detailed planning and design of the test started with the beginning fiscal year 1996. The overall objective of the Single Heater Test was to gain an understanding of the coupled thermal, mechanical, hydrological, and chemical processes that are anticipated to occur in the local rock-mass in the potential repository as a result of heat from radioactive decay of the emplaced waste. This included making a priori predictions of the test results using existing models and subsequently refining or modifying the models, on the basis of comparative and interpretive analyses of the measurements and predictions. A second, no less important, objective was to try out, in a full-scale field setting, the various instruments and equipment to be employed in the future on a much larger, more complex, thermal test of longer duration, such as the Drift Scale Test. This ''shake down'' or trial aspect of the Single Heater Test applied not just to the hardware, but also to the teamwork and cooperation between

  7. Companded single sideband satellite transmission

    Brown, R. J.; Guha, M. L.; Hedinger, R. A.; Hoover, M. L.

    Investigations have shown companded single sideband transmission (CSSB) of up to 7800 voice circuits per transponder on TELSTAR 3 to be technically feasible. Achievement of this capacity increases the transponder utilization of TELSTAR 3 more than four-fold with respect to current FDM-FM transmission. The major new factors that permit this enhanced capability are the employment of solid-state power amplifiers (SSPAs) aboard TELSTAR 3, the introduction of syllabic compandors to subjectively reduce the effect of increased link noise, and the recognition of the reality of reduced long-term average power per circuit on selected trunks. The analysis, experiments, and implementation supporting this capability are described.

  8. Single Bacterium Detection Using Sers

    Gonchukov, S. A.; Baikova, T. V.; Alushin, M. V.; Svistunova, T. S.; Minaeva, S. A.; Ionin, A. A.; Kudryashov, S. I.; Saraeva, I. N.; Zayarny, D. A.

    2016-02-01

    This work is devoted to the study of a single Staphylococcus aureus bacterium detection using surface-enhanced Raman spectroscopy (SERS) and resonant Raman spectroscopy (RS). It was shown that SERS allows increasing sensitivity of predominantly low frequency lines connected with the vibrations of Amide, Proteins and DNA. At the same time the lines of carotenoids inherent to this kind of bacterium are well-detected due to the resonance Raman scattering mechanism. The reproducibility and stability of Raman spectra strongly depend on the characteristics of nanostructured substrate, and molecular structure and size of the tested biological object.

  9. Single electron states in polyethylene

    We report computer simulations of an excess electron in various structural motifs of polyethylene at room temperature, including lamellar and interfacial regions between amorphous and lamellae, as well as nanometre-sized voids. Electronic properties such as density of states, mobility edges, and mobilities are computed on the different phases using a block Lanczos algorithm. Our results suggest that the electronic density of states for a heterogeneous material can be approximated by summing the single phase density of states weighted by their corresponding volume fractions. Additionally, a quantitative connection between the localized states of the excess electron and the local atomic structure is presented

  10. SINGLE HEATER TEST FINAL REPORT

    J.B. Cho

    1999-05-01

    The Single Heater Test is the first of the in-situ thermal tests conducted by the U.S. Department of Energy as part of its program of characterizing Yucca Mountain in Nevada as the potential site for a proposed deep geologic repository for the disposal of spent nuclear fuel and high-level nuclear waste. The Site Characterization Plan (DOE 1988) contained an extensive plan of in-situ thermal tests aimed at understanding specific aspects of the response of the local rock-mass around the potential repository to the heat from the radioactive decay of the emplaced waste. With the refocusing of the Site Characterization Plan by the ''Civilian Radioactive Waste Management Program Plan'' (DOE 1994), a consolidated thermal testing program emerged by 1995 as documented in the reports ''In-Situ Thermal Testing Program Strategy'' (DOE 1995) and ''Updated In-Situ Thermal Testing Program Strategy'' (CRWMS M&O 1997a). The concept of the Single Heater Test took shape in the summer of 1995 and detailed planning and design of the test started with the beginning fiscal year 1996. The overall objective of the Single Heater Test was to gain an understanding of the coupled thermal, mechanical, hydrological, and chemical processes that are anticipated to occur in the local rock-mass in the potential repository as a result of heat from radioactive decay of the emplaced waste. This included making a priori predictions of the test results using existing models and subsequently refining or modifying the models, on the basis of comparative and interpretive analyses of the measurements and predictions. A second, no less important, objective was to try out, in a full-scale field setting, the various instruments and equipment to be employed in the future on a much larger, more complex, thermal test of longer duration, such as the Drift Scale Test. This ''shake down'' or trial aspect of the Single Heater Test applied

  11. Single crystalline mesoporous silicon nanowires

    Hochbaum, Allon; Dargas, Daniel; Hwang, Yun Jeong; Yang, Peidong

    2009-08-18

    Herein we demonstrate a novel electroless etching synthesis of monolithic, single-crystalline, mesoporous silicon nanowire arrays with a high surface area and luminescent properties consistent with conventional porous silicon materials. The photoluminescence of these nanowires suggest they are composed of crystalline silicon with small enough dimensions such that these arrays may be useful as photocatalytic substrates or active components of nanoscale optoelectronic devices. A better understanding of this electroless route to mesoporous silicon could lead to facile and general syntheses of different narrow bandgap semiconductor nanostructures for various applications.

  12. Microscopic identification of single particles

    McCrone, W.C.

    1961-01-01

    To identify single small particles in trace analysis, the microscopist uses morphological analysis, i.e., shape characteristics either of the object as a whole or of the significant component parts. The less experienced microscopists must measure quantitative properties which can be tabulated for ready reference. Examples of these characteristics and quantitative properties further explain the measuring process. A great deal of time and effort is necessary to acquire the necessary skill and confidence to do microscopic analysis. Fusion methods are an example of simplified procedures for less trained personnel. The examples illustrate applications in air pollution, pathology, criminology, and other disciplines. 6 references, 1 figure, 4 tables.

  13. Microfluidics for single cell analysis

    Jensen, Marie Pødenphant

    cells, and simultaneously be fabricated and operated at low costs and be user-friendly. These challenges were addressed through development of two microfluidic devices, one for rare cell isolation based on pinched flow fractionation (PFF) and one for single cell capture based on hydrodynamic trapping....... Both devices were fabricated by injection moulding with a nickel master. CTC isolation was realised using PFF, which is a passive, size-based microfluidic technique. The focus was mainly on experimental work; however designs were based on flow calculations and analysed with numerical simulations to...

  14. Magnetic remanence in single atoms.

    Donati, F; Rusponi, S; Stepanow, S; Wäckerlin, C; Singha, A; Persichetti, L; Baltic, R; Diller, K; Patthey, F; Fernandes, E; Dreiser, J; Šljivančanin, Ž; Kummer, K; Nistor, C; Gambardella, P; Brune, H

    2016-04-15

    A permanent magnet retains a substantial fraction of its saturation magnetization in the absence of an external magnetic field. Realizing magnetic remanence in a single atom allows for storing and processing information in the smallest unit of matter. We show that individual holmium (Ho) atoms adsorbed on ultrathin MgO(100) layers on Ag(100) exhibit magnetic remanence up to a temperature of 30 kelvin and a relaxation time of 1500 seconds at 10 kelvin. This extraordinary stability is achieved by the realization of a symmetry-protected magnetic ground state and by decoupling the Ho spin from the underlying metal by a tunnel barrier. PMID:27081065

  15. A single pass electron accelerator

    Higher volumes, increasing competition and the need to improve quality have led us to re-examine the process for irradiation of tubing and wire. Traditionally in Raychem, product irradiation has involved the use of large multi-purpose facilities that were designed to handle relatively small volumes of a large variety of products as a separate process. Today, with larger volumes of certain products, there is an interest in combining processes to improve quality and reduce cost. We have recently designed and constructed a small, low voltage accelerator system that can be placed in-line with another manufacturing process and can uniformly irradiate a tube or wire product in a single pass. The system is comprised to two conventional accelerator systems having elongated filaments and placed on opposite sides of a linear product path. The ribbon shaped electron beams from these two accelerators are scanned, after acceleration toward the product path, in a conventional manner and 180 degrees out of phase from each other. The two accelerated electron beams then enter a third magnetic field that is synchronous with the scanning magnets and whose oscillating polarity is such that the ribbon beams are converged onto a tubular shaped window close to and around a segment of the product path. Trials with a prototype system have produced tubing having a dose concentricity of better than ± 10 percent on a single pass through the system. (author)

  16. A single pass electron accelerator

    Schuetz, M.N.; Vroom, D.A. [Raychem Corp., Menlo Park, CA (United States)

    1995-10-01

    Higher volumes, increasing competition and the need to improve quality have led us to re-examine the process for irradiation of tubing and wire. Traditionally in Raychem, product irradiation has involved the use of large multi-purpose facilities that were designed to handle relatively small volumes of a large variety of products as a separate process. Today, with larger volumes of certain products, there is an interest in combining processes to improve quality and reduce cost. We have recently designed and constructed a small, low voltage accelerator system that can be placed in-line with another manufacturing process and can uniformly irradiate a tube or wire product in a single pass. The system is comprised to two conventional accelerator systems having elongated filaments and placed on opposite sides of a linear product path. The ribbon shaped electron beams from these two accelerators are scanned, after acceleration toward the product path, in a conventional manner and 180 degrees out of phase from each other. The two accelerated electron beams then enter a third magnetic field that is synchronous with the scanning magnets and whose oscillating polarity is such that the ribbon beams are converged onto a tubular shaped window close to and around a segment of the product path. Trials with a prototype system have produced tubing having a dose concentricity of better than {+-} 10 percent on a single pass through the system. (author).

  17. A single pass electron accelerator

    Schuetz, Marlin N.; Vroom, David A.

    1995-02-01

    Higher volumes, increasing competition and the need to improve quality have led us to re-examine the process for irradiation of tubing and wire. Traditionallyin Raychem, product irradiation has involved the use of large multi-purpose facilities that were designed to handle relatively small volumes of a large variety of products as a separate process. Today, with larger volumes of certain products, there is an interest in combining processes to improve quality and reduce cost. We have recently designed and constructed a small, low voltage accelerator system that can be placed in-line with another manufacturing process and can uniformly irradiate a tube or wire product in a single pass. The system is comprised of two conventional accelerator systems having elongated filaments and placed on opposite sides of a linear product path. The ribbon shaped electron beams from these two accelerators are scanned, after acceleration toward the product path, in a conventional manner and 180 degrees out of phase from each other. The two accelerated electron beams then enter a third magnetic field that is synchronous with the scanning magnets and whose oscillating polarity is such that the ribbon beams are converged onto a tubular shaped window close to and around a segment of the product path. Trials with a prototype system have produced tubing having a dose concentricity of better than ± 10 percent on a single pass through the system.

  18. Magnetotransport of single crystalline YSb

    Ghimire, N. J.; Botana, A. S.; Phelan, D.; Zheng, H.; Mitchell, J. F.

    2016-06-01

    We report magnetic field dependent transport measurements on a single crystal of cubic YSb together with first principles calculations of its electronic structure. The transverse magnetoresistance does not saturate up to 9 T and attains a value of 75 000% at 1.8 K. The Hall coefficient is electron-like at high temperature, changes sign to hole-like between 110 and 50 K, and again becomes electron-like below 50 K. First principles calculations show that YSb is a compensated semimetal with a qualitatively similar electronic structure to that of isostructural LaSb and LaBi, but with larger Fermi surface volume. The measured electron carrier density and Hall mobility calculated at 1.8 K, based on a single band approximation, are 6.5× {{10}20} cm‑3 and 6.2× {{10}4} cm2 Vs‑1, respectively. These values are comparable with those reported for LaBi and LaSb. Like LaBi and LaSb, YSb undergoes a magnetic field-induced metal-insulator-like transition below a characteristic temperature T m, with resistivity saturation below 13 K. Thickness dependent electrical resistance measurements show a deviation of the resistance behavior from that expected for a normal metal; however, they do not unambiguously establish surface conduction as the mechanism for the resistivity plateau.

  19. Single-molecule stochastic resonance

    Hayashi, K; Manosas, M; Huguet, J M; Ritort, F; 10.1103/PhysRevX.2.031012

    2012-01-01

    Stochastic resonance (SR) is a well known phenomenon in dynamical systems. It consists of the amplification and optimization of the response of a system assisted by stochastic noise. Here we carry out the first experimental study of SR in single DNA hairpins which exhibit cooperatively folding/unfolding transitions under the action of an applied oscillating mechanical force with optical tweezers. By varying the frequency of the force oscillation, we investigated the folding/unfolding kinetics of DNA hairpins in a periodically driven bistable free-energy potential. We measured several SR quantifiers under varied conditions of the experimental setup such as trap stiffness and length of the molecular handles used for single-molecule manipulation. We find that the signal-to-noise ratio (SNR) of the spectral density of measured fluctuations in molecular extension of the DNA hairpins is a good quantifier of the SR. The frequency dependence of the SNR exhibits a peak at a frequency value given by the resonance match...

  20. Magnetic levitation of single cells.

    Durmus, Naside Gozde; Tekin, H Cumhur; Guven, Sinan; Sridhar, Kaushik; Arslan Yildiz, Ahu; Calibasi, Gizem; Ghiran, Ionita; Davis, Ronald W; Steinmetz, Lars M; Demirci, Utkan

    2015-07-14

    Several cellular events cause permanent or transient changes in inherent magnetic and density properties of cells. Characterizing these changes in cell populations is crucial to understand cellular heterogeneity in cancer, immune response, infectious diseases, drug resistance, and evolution. Although magnetic levitation has previously been used for macroscale objects, its use in life sciences has been hindered by the inability to levitate microscale objects and by the toxicity of metal salts previously applied for levitation. Here, we use magnetic levitation principles for biological characterization and monitoring of cells and cellular events. We demonstrate that each cell type (i.e., cancer, blood, bacteria, and yeast) has a characteristic levitation profile, which we distinguish at an unprecedented resolution of 1 × 10(-4) g ⋅ mL(-1). We have identified unique differences in levitation and density blueprints between breast, esophageal, colorectal, and nonsmall cell lung cancer cell lines, as well as heterogeneity within these seemingly homogenous cell populations. Furthermore, we demonstrate that changes in cellular density and levitation profiles can be monitored in real time at single-cell resolution, allowing quantification of heterogeneous temporal responses of each cell to environmental stressors. These data establish density as a powerful biomarker for investigating living systems and their responses. Thereby, our method enables rapid, density-based imaging and profiling of single cells with intriguing applications, such as label-free identification and monitoring of heterogeneous biological changes under various physiological conditions, including antibiotic or cancer treatment in personalized medicine. PMID:26124131

  1. Single wafer rapid thermal multiprocessing

    Future success in microelectronics will demand rapid innovation, rapid product introduction and ability to react to a change in technological and business climate quickly. These technological advances in integrated electronics will require development of flexible manufacturing technology for VLSI systems. However, the current approach of establishing factories for mass manufacturing of chips at a cost of more than 200 million dollars is detrimental to flexible manufacturing. The authors propose concepts of a micro factory which may be characterized by more economical small scale production, higher flexibility to accommodate many products on several processes, and faster turnaround and learning. In-situ multiprocessing equipment where several process steps can be done in sequence may be a key ingredient in this approach. For this environment to be flexible, the equipment must have ability to change processing environment, requiring extensive in-situ measurements and real time control. This paper describes the development of a novel single wafer rapid thermal multiprocessing (RTM) reactor for next generation flexible VLSI manufacturing. This reactor will combine lamp heating, remote microwave plasma and photo processing in a single cold-wall chamber, with applications for multilayer in-situ growth and deposition of dielectrics, semiconductors and metals

  2. Single Spin Asymmetries from a Single Wilson Loop

    Boer, Daniël; Echevarria, Miguel G.; Mulders, Piet J.; Zhou, Jian

    2016-03-01

    We study the leading-power gluon transverse-momentum-dependent distributions (TMDs) of relevance to the study of asymmetries in the scattering off transversely polarized hadrons. Next-to-leading-order perturbative calculations of these TMDs show that at large transverse momentum they have common dynamical origins but that in the limit of a small longitudinal momentum fraction x , only one origin remains. We find that in this limit, only the dipole-type gluon TMDs survive and become identical to each other. At small x , they are all given by the expectation value of a single Wilson loop inside the transversely polarized hadron, the so-called spin-dependent odderon. This universal origin of transverse spin asymmetries at small x is of importance to current and future experimental studies, paving the way to a better understanding of the role of gluons in the three-dimensional structure of spin-polarized protons.

  3. Single spin asymmetries from a single Wilson loop

    Boer, Daniël; Mulders, Piet; Zhou, Jian

    2015-01-01

    We study the leading-power gluon transverse momentum dependent distributions (TMDs) of relevance to asymmetries in the scattering off transversely polarized hadrons. Next-to-leading-order perturbative calculations of these TMDs show that at large transverse momentum they have common dynamical origins, but that in the limit of small longitudinal momentum fraction $x$ only one origin remains. We find that in this limit only the $C$-odd or dipole-type gluon TMDs survive and become identical to each other. At small $x$ they are all given by the expectation value of a single Wilson loop inside the transversely polarized hadron, the so-called spin-dependent odderon. This universal origin of transverse spin asymmetries at small $x$ is of importance to current and future experimental studies, paving the way to a better understanding of the role of gluons in the three-dimensional structure of spin-polarized protons.

  4. Single photon emission computerized tomography

    In this thesis two single-photon emission tomographic techniques are presented: (a) longitudinal tomography with a rotating slanting-hole collimator, and (b) transversal tomography with a rotating gamma camera. These methods overcome the disadvantages of conventional scintigraphy. Both detection systems and the image construction methods are explained and comparisons with conventional scintigraphy are drawn. One chapter is dedicated to the determination of system parameters like spatial resolution, contrast, detector uniformity, and size of the object, by phantom studies. In separate chapters the results are presented of detection of tumors and metastases in the liver and the liver hilus; skeletal diseases; various pathological aberrations of the brain; and myocardial perfusion. The possible use of these two ect's for other organs and body areas is discussed in the last chapter. (Auth.)

  5. Electrochemical detection of single molecules.

    Fan, F R; Bard, A J

    1995-02-10

    The electrochemical behavior of a single molecule can be observed by trapping a small volume of a dilute solution of the electroactive species between an ultramicroelectrode tip with a diameter of approximately 15 nanometers and a conductive substrate. A scanning electrochemical microscope was used to adjust the tip-substrate distance ( approximately 10 nanometers), and the oxidation of [(trimethylammonio)methyl] ferrocene (Cp(2)FeTMA(+)) to Cp(2)FeTMA(2+) was carried out. The response was stochastic, and anodic current peaks were observed as the molecule moved into and out of the electrode-substrate gap. Similar experiments were performed with a solution containing two redox species, ferrocene carboxylate (Cp(2)FeCOO(-)) and Os(bpy)(3)(2+) (bpy is 2,2'-bipyridyl). PMID:17813918

  6. Single-cycle nonlinear optics

    Max-Planck-Institut fur Quantenoptik; Goulielmakis, E.; Schultze, M.; Hofstetter, M.; Yakovlev, V. S.; Gagnon, J.; Uiberacker, M.; Aquila, A. L.; gullikson, E. M.; attwood, D. T.; Kienberger, R.; Krausz, F.; Kleineberg, U.

    2008-11-05

    Nonlinear optics plays a central role in the advancement of optical science and laser-based technologies. We report on the confinement of the nonlinear interaction of light with matter to a single wave cycle and demonstrate its utility for time-resolved and strong-field science. The electric field of 3.3-femtosecond, 0.72-micron laser pulses with a controlled and measured waveform ionizes atoms near the crests of the central wave cycle, with ionization being virtually switched off outside this interval. Isolated sub-100-attosecond pulses of extreme ultraviolet light (photon energy {approx} 80 electron volts), containing {approx} 0.5 nanojoule of energy, emerge from the interaction with a conversion efficiency of {approx} 10{sup -6}. These tools enable the study of the precision control of electron motion with light fields and electron-electron interactions with a resolution approaching the atomic unit of time ({approx} 24 attoseconds).

  7. Single-bunch kicker pulser

    The single-bunch kicker magnet is powered by a capacitor discharge pulser. The ferrite-core magnet is used to kick out one of twelve proton bunches circulating in the AGS (Alternating Gradient Synchrotron) into the experimental area. The magnet current pulse has a half-sinusoid shape, with a peak current of 2800 A. The pulse current rises and falls to zero, with minimum undershoot, in 410 nsec to minimize effects on adjacent bunches. The magnet inductance is 1.0 μHy. The pulser is mounted on the kicker magnet in the AGS ring, and is exposed to ionizing radiation. The HVDC power supply, controls, monitoring, and auxiliary circuits are housed approximately 300 feet away external to the ring. A two-gap thyratron is used to discharge the energy storage capacitor. Two hydrogen diodes are series connected to function as an inverse diode

  8. Single-bunch kicker pulser

    Frey, W.W.

    1983-01-01

    The single-bunch kicker magnet is powered by a capacitor discharge pulser. The ferrite-core magnet is used to kick out one of twelve proton bunches circulating in the AGS (Alternating Gradient Synchrotron) into the experimental area. The magnet current pulse has a half-sinusoid shape, with a peak current of 2800 A. The pulse current rises and falls to zero, with minimum undershoot, in 410 nsec to minimize effects on adjacent bunches. The magnet inductance is 1.0 ..mu..Hy. The pulser is mounted on the kicker magnet in the AGS ring, and is exposed to ionizing radiation. The HVDC power supply, controls, monitoring, and auxiliary circuits are housed approximately 300 feet away external to the ring. A two-gap thyratron is used to discharge the energy storage capacitor. Two hydrogen diodes are series connected to function as an inverse diode.

  9. Single-contact tunneling thermometry

    Maksymovych, Petro

    2016-02-23

    A single-contact tunneling thermometry circuit includes a tunnel junction formed between two objects. Junction temperature gradient information is determined based on a mathematical relationship between a target alternating voltage applied across the junction and the junction temperature gradient. Total voltage measured across the junction indicates the magnitude of the target alternating voltage. A thermal gradient is induced across the junction. A reference thermovoltage is measured when zero alternating voltage is applied across the junction. An increasing alternating voltage is applied while measuring a thermovoltage component and a DC rectification voltage component created by the applied alternating voltage. The target alternating voltage is reached when the thermovoltage is nullified or doubled by the DC rectification voltage depending on the sign of the reference thermovoltage. Thermoelectric current and current measurements may be utilized in place of the thermovoltage and voltage measurements. The system may be automated with a feedback loop.

  10. Spectral compression of single photons

    Lavoie, Jonathan; Wright, Logan G; Fedrizzi, Alessandro; Resch, Kevin J

    2013-01-01

    Photons are critical to quantum technologies since they can be used for virtually all quantum information tasks: in quantum metrology, as the information carrier in photonic quantum computation, as a mediator in hybrid systems, and to establish long distance networks. The physical characteristics of photons in these applications differ drastically; spectral bandwidths span 12 orders of magnitude from 50 THz for quantum-optical coherence tomography to 50 Hz for certain quantum memories. Combining these technologies requires coherent interfaces that reversibly map centre frequencies and bandwidths of photons to avoid excessive loss. Here we demonstrate bandwidth compression of single photons by a factor 40 and tunability over a range 70 times that bandwidth via sum-frequency generation with chirped laser pulses. This constitutes a time-to-frequency interface for light capable of converting time-bin to colour entanglement and enables ultrafast timing measurements. It is a step toward arbitrary waveform generatio...

  11. The Single Parent and Public Policy.

    Schorr, Alvin L.; Moen, Phyllis

    1979-01-01

    Single parent families are misrepresented to the general public and to themselves. Issues change focus if one views single parenthood as a normal and permanent feature of our social landscape. (Author/EB)

  12. Single-port laparoscopic surgery.

    Tsai, Anthony Y; Selzer, Don J

    2010-01-01

    Laparoscopic surgery performed through a single-incision is gaining popularity. The demand from the public for even less invasive procedures will motivate surgeons, industry, and academic centers to explore the possibilities and refine the technology. Although the idea seems quite attractive, there are several technological obstacles that are yet to be conquered by improved technology or additional training. The question of safety has yet to be answered and will require well-designed randomized control trials. Opponents to the approach argue that the size of the single incision (see Table 1) is frequently larger than all the standard laparoscopy incisions combined. On the other hand, proponents remember a similar argument from traditional open surgeons during the initial development of laparoscopy. That argument was quickly discredited when the immediate benefits oflaparoscopy were compared with patients undergoing surgery with small laparotomy incisions. During the development of a new technique, the learning curve exposes patients to risk and society to expense. LESS pioneers appear to have reached a level of comfort with technology and techniques that paves the way for scientific scrutiny. Perhaps, the surgical community will capitalize on this situation with randomized, controlled studies and sound evidence to support or refute the benefits of LESS. If we do not seize this opportunity, patient demand and industry's dual edge message of financial success versus fear of losing referrals will lead to a scenario similar to the development of laparoscopic cholecystectomy in the 1990s. Regardless of its future, the surgical community will still benefit from a renewed excitement as surgeons aim to continually reduce the amount of pain and trauma our patients must endure. In addition, technological advances on instrumentation will benefit the field of laparoscopy and improve patient care. PMID:20919511

  13. Single cancer cell analysis on a chip

    Yang, Yoonsun

    2016-01-01

    Cancer cells in blood may represent “a real time liquid biopsy” through the interrogation of single cancer cells thereby determining the outspread of their heterogeneity and guiding therapy. In this thesis, we focused on single cancer cell analysis downstream of the isolation of cancer cells from blood. We designed and developed various microfluidic devices for genetic and phenotypic characterization of single cancer cells. The limited DNA content in a single cell requires DNA amplification t...

  14. Single and multiband THz Metamaterial Polarizers

    Sangala, Bagvanth Reddy; Nagarajan, Arvind; Deshmukh, Prathmesh; Surdi, Harshad; Rana, Goutam; Gopal, Achanta Venu; Prabhu, S. S.

    2015-01-01

    We report single and multiband linear polarizers for terahertz (THz) frequencies using cut-wire metamaterials (MM). The MMs are designed by finite element method, fabricated by electron beam lithography, and characterized by THz time-domain spectroscopy. The MM unit cells consist of single or multiple length cut-wire pads of gold on semi-insulating Gallium Arsenide for single or multiple band polarizers. The dependence of the resonance frequency of the single band polarizer on the length of t...

  15. Stacking fault energy in some single crystals

    Aditya M.Vora

    2012-01-01

    The stacking fault energy of single crystals has been reported using the peak shift method.Presently studied all single crystals are grown by using a direct vapor transport (DVT) technique in the laboratory.The structural characterizations of these crystals are made by XRD.Considerable variations are shown in deformation (α) and growth (β) probabilities in single crystals due to off-stoichiometry,which possesses the stacking fault in the single crystal.

  16. Direct imaging of single UvrD helicase dynamics on long single-stranded DNA

    Lee, Kyung Suk; Balci, Hamza; Jia, Haifeng; Lohman, Timothy M.; Ha, Taekjip

    2013-01-01

    Fluorescence imaging of single-protein dynamics on DNA has been largely limited to double-stranded DNA or short single-stranded DNA. We have developed a hybrid approach for observing single proteins moving on laterally stretched kilobase-sized ssDNA. Here we probed the single-stranded DNA translocase activity of Escherichia coli UvrD by single fluorophore tracking, while monitoring DNA unwinding activity with optical tweezers to capture the entire sequence of protein binding, single-stranded ...

  17. The Promise of Single-Sex Classes

    Stotsky, Sandra

    2012-01-01

    Despite the enthusiasm and the absence of definitive research on the pros and cons of single-sex classes, a 2011 article in Science, titled "The Pseudoscience of Single-Sex Schooling," by a new organization called American Council for CoEducational Schooling (ACCES) came out with the astonishing conclusion that single-sex education is ineffective…

  18. Single Subject Research: Applications to Special Education

    Cakiroglu, Orhan

    2012-01-01

    Single subject research is a scientific research methodology that is increasingly used in the field of special education. Therefore, understanding the unique characteristics of single subject research methodology is critical both for educators and practitioners. Certain characteristics make single subject research one of the most preferred…

  19. Single-Parent Families in Rural Communities

    Lewis, Ken

    1978-01-01

    Presenting national statistics on single-parent families, this article illustrates the need for serious study of this phenomenon, suggesting that changing divorce laws, increased single-parent adoptions, and an increase in the number of supportive services for single-parent families are contingencies having significant bearing upon the…

  20. The Advantages of Single-Sex Education

    Hughes, Teresa A.

    2006-01-01

    Traditionally, single-sex education has been provided in the form of private schooling. Title IX regulations have loosened as a result of the No Child Left Behind Legislation; therefore, public school districts now have the legal right to create single-sex classes or single-sex schools if they deem it to be in the best interest of their students.…

  1. Accurate pose estimation using single marker single camera calibration system

    Pati, Sarthak; Erat, Okan; Wang, Lejing; Weidert, Simon; Euler, Ekkehard; Navab, Nassir; Fallavollita, Pascal

    2013-03-01

    Visual marker based tracking is one of the most widely used tracking techniques in Augmented Reality (AR) applications. Generally, multiple square markers are needed to perform robust and accurate tracking. Various marker based methods for calibrating relative marker poses have already been proposed. However, the calibration accuracy of these methods relies on the order of the image sequence and pre-evaluation of pose-estimation errors, making the method offline. Several studies have shown that the accuracy of pose estimation for an individual square marker depends on camera distance and viewing angle. We propose a method to accurately model the error in the estimated pose and translation of a camera using a single marker via an online method based on the Scaled Unscented Transform (SUT). Thus, the pose estimation for each marker can be estimated with highly accurate calibration results independent of the order of image sequences compared to cases when this knowledge is not used. This removes the need for having multiple markers and an offline estimation system to calculate camera pose in an AR application.

  2. Single conversion stage amplifier - SICAM

    Ljusev, P.

    2005-12-15

    This Ph.D. thesis presents a thorough analysis of the so called SICAM - SIngle Converter stage AMplifier approach to building direct energy conversion audio power amplifiers. The mainstream approach for building isolated audio power amplifiers today consists of isolated DC power supply and Class D amplifier, which essentially represents a two stage solution, where each of the components can be viewed as separate and independent part. The proposed SICAM solution strives for direct energy conversion from the mains to the audio output, by dedicating the operation of the components one to another and integrating their functions, so that the final audio power amplifier represents a single-stage topology with higher efficiency, lower volume, less board space, lower component count and subsequently lower cost. The SICAM approach is both applicable to non-isolated and isolated audio power amplifiers, but the problems encountered in these two cases are different. Non-isolated SICAM solutions are intended for both AC mains-connected and battery-powered devices. In non-isolated mains-connected SICAMs the main idea is to simplify the power supply or even provide integrated power factor correction (PFC) functions, while still maintaining low component stress and good audio performance by generally decreasing the input voltage level to the Class D audio power amplifier. On the other hand, non-isolated battery-powered SICAMs have to cope with the ever changing battery voltage and provide output voltage levels which are both lower and higher than the battery voltage, while still being simple and single-stage energy conversion solutions. In isolated SICAMs the isolation transformer adjusts the voltage level on the secondary side to the desired level, so the main challenges here are decreasing the size of the magnetic core and reducing the number and size of bulky reactive components as much as possible. The main focus of this thesis is directed towards the isolated SICAMs and

  3. Engineered Quantum Dot Single Photon Sources

    Buckley, Sonia; Vuckovic, Jelena

    2012-01-01

    Fast, high efficiency, and low error single photon sources are required for implementation of a number of quantum information processing applications. The fastest triggered single photon sources to date have been demonstrated using epitaxially grown semiconductor quantum dots (QDs), which can be conveniently integrated with optical microcavities. Recent advances in QD technology, including demonstrations of high temperature and telecommunications wavelength single photon emission, have made QD single photon sources more practical. Here we discuss the applications of single photon sources and their various requirements, before reviewing the progress made on a quantum dot platform in meeting these requirements.

  4. Prions: Beyond a Single Protein.

    Das, Alvin S; Zou, Wen-Quan

    2016-07-01

    Since the term protein was first coined in 1838 and protein was discovered to be the essential component of fibrin and albumin, all cellular proteins were presumed to play beneficial roles in plants and mammals. However, in 1967, Griffith proposed that proteins could be infectious pathogens and postulated their involvement in scrapie, a universally fatal transmissible spongiform encephalopathy in goats and sheep. Nevertheless, this novel hypothesis had not been evidenced until 1982, when Prusiner and coworkers purified infectious particles from scrapie-infected hamster brains and demonstrated that they consisted of a specific protein that he called a "prion." Unprecedentedly, the infectious prion pathogen is actually derived from its endogenous cellular form in the central nervous system. Unlike other infectious agents, such as bacteria, viruses, and fungi, prions do not contain genetic materials such as DNA or RNA. The unique traits and genetic information of prions are believed to be encoded within the conformational structure and posttranslational modifications of the proteins. Remarkably, prion-like behavior has been recently observed in other cellular proteins-not only in pathogenic roles but also serving physiological functions. The significance of these fascinating developments in prion biology is far beyond the scope of a single cellular protein and its related disease. PMID:27226089

  5. Single scatter electron Monte Carlo

    Svatos, M.M. [Lawrence Livermore National Lab., CA (United States)|Wisconsin Univ., Madison, WI (United States)

    1997-03-01

    A single scatter electron Monte Carlo code (SSMC), CREEP, has been written which bridges the gap between existing transport methods and modeling real physical processes. CREEP simulates ionization, elastic and bremsstrahlung events individually. Excitation events are treated with an excitation-only stopping power. The detailed nature of these simulations allows for calculation of backscatter and transmission coefficients, backscattered energy spectra, stopping powers, energy deposits, depth dose, and a variety of other associated quantities. Although computationally intense, the code relies on relatively few mathematical assumptions, unlike other charged particle Monte Carlo methods such as the commonly-used condensed history method. CREEP relies on sampling the Lawrence Livermore Evaluated Electron Data Library (EEDL) which has data for all elements with an atomic number between 1 and 100, over an energy range from approximately several eV (or the binding energy of the material) to 100 GeV. Compounds and mixtures may also be used by combining the appropriate element data via Bragg additivity.

  6. Single Molecule Studies of Chromatin

    Jeans, C; Thelen, M P; Noy, A

    2006-02-06

    In eukaryotic cells, DNA is packaged as chromatin, a highly ordered structure formed through the wrapping of the DNA around histone proteins, and further packed through interactions with a number of other proteins. In order for processes such as DNA replication, DNA repair, and transcription to occur, the structure of chromatin must be remodeled such that the necessary enzymes can access the DNA. A number of remodeling enzymes have been described, but our understanding of the remodeling process is hindered by a lack of knowledge of the fine structure of chromatin, and how this structure is modulated in the living cell. We have carried out single molecule experiments using atomic force microscopy (AFM) to study the packaging arrangements in chromatin from a variety of cell types. Comparison of the structures observed reveals differences which can be explained in terms of the cell type and its transcriptional activity. During the course of this project, sample preparation and AFM techniques were developed and optimized. Several opportunities for follow-up work are outlined which could provide further insight into the dynamic structural rearrangements of chromatin.

  7. Single Image Improvement using Superresolution

    Shwetambari Shinde

    2012-05-01

    Full Text Available Methods for super-resolution can be broadly classified into two families of methods: (i The classicalmulti-image super-resolution (combining images obtained at subpixel misalignments, and (ii ExampleBased super-resolution (learning correspondence between low and high resolution image patches from a database. In this paper we propose a unified framework for combining these two families of methods. We further show how this combined approach can be applied to obtain super resolution from as little as a single image (with no database or prior examples. Our approach is based on the observation that patches in a natural image tend to redundantly recur many times inside the image, both within the same scale, as well as across different scales. Recurrence of patches within the same image scale (at sub pixel misalignments gives rise to the classical super-resolution, whereas recurrence of patches across different scales of the same image gives rise to example-based super-resolution. Our approach attempts to recover at each pixel its best possible resolution increase based on its patch redundancy within and across scales.

  8. Single-Scale Natural SUSY

    Randall, Lisa

    2012-01-01

    We consider the prospects for natural SUSY models consistent with current data. Recent constraints make the standard paradigm unnatural so we consider what could be a minimal extension consistent with what we now know. The most promising such scenarios extend the MSSM with new tree-level Higgs interactions that can lift its mass to at least 125 GeV and also allow for flavor-dependent soft terms so that the third generation squarks are lighter than current bounds on the first and second generation squarks. We argue that a common feature of almost all such models is the need for a new scale near 10 TeV, such as a scale of Higgsing or confinement of a new gauge group. We consider the question whether such a model can naturally derive from a single mass scale associated with supersymmetry breaking. Most such models simply postulate new scales, leaving their proximity to the scale of MSSM soft terms a mystery. This coincidence problem may be thought of as a mild tuning, analogous to the usual mu problem. We find t...

  9. Single-photon emission tomography.

    Goffin, Karolien; van Laere, Koen

    2016-01-01

    Single-photon emission computed tomography (SPECT) is a functional nuclear imaging technique that allows visualization and quantification of different in vivo physiologic and pathologic features of brain neurobiology. It has been used for many years in diagnosis of several neurologic and psychiatric disorders. In this chapter, we discuss the current state-of-the-art of SPECT imaging of brain perfusion and dopamine transporter (DAT) imaging. Brain perfusion SPECT imaging plays an important role in the localization of the seizure onset zone in patients with refractory epilepsy. In cerebrovascular disease, it can be useful in determining the cerebrovascular reserve. After traumatic brain injury, SPECT has shown perfusion abnormalities despite normal morphology. In the context of organ donation, the diagnosis of brain death can be made with high accuracy. In neurodegeneration, while amyloid or (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) are the nuclear diagnostic tools of preference for early and differential diagnosis of dementia, perfusion SPECT imaging can be useful, albeit with slightly lower accuracy. SPECT imaging of the dopamine transporter system is widely available in Europe and Asia, but since recently also in the USA, and has been accepted as an important diagnostic tool in the early and differential diagnosis of parkinsonism in patients with unclear clinical features. The combination of perfusion SPECT (or FDG-PET) and DAT imaging provides differential diagnosis between idiopathic Parkinson's disease, Parkinson-plus syndromes, dementia with Lewy bodies, and essential tremor. PMID:27432669

  10. Silicon single-electron devices

    Single-electron devices (SEDs) are attracting a lot of attention because of their capability of manipulating just one electron. For their operation, they utilize the Coulomb blockade (CB), which occurs in tiny structures made from conductive material due to the electrostatic interactions of confined electrons. Metals or III-V compound semiconductors have so far been used to investigate the CB and related phenomena from the physical point of view. However, silicon is preferable from the viewpoint of applications to integrated circuits because, on a silicon substrate, SEDs can be used in combination with conventional complementary metal-oxide-semiconductor (CMOS) circuits. In addition, the well established fabrication technologies for CMOS large-scale integrated circuits (LSIs) can be applied to making such small structures. LSI applications of the silicon SEDs can be categorized into two fields: memory and logic. Many kinds of device structure and fabrication process have been proposed and tested for these purposes. This paper introduces the current status of silicon-based SED studies for LSI applications. (author)

  11. Formal and Informal Support Systems for Single Women and Single Mothers in Malaysia

    Endut Noraida; Azmawati Azman Azwan; Mohd Hashim Intan Hashimah

    2015-01-01

    The aim of this paper is to explore how formal and informal supports were being experienced by single women and single mothers in Malaysia. Closely examining formal and informal support systems reported by single mothers and single women in Malaysia, participants generally reported good and were mainly satisfied with their informal support system. Informal support system comprised of mostly family members and friends. However, formal support system was still lacking and both single women and ...

  12. Evaluation of Pain in Single and Multi Rooted Teeth Treated in Single Visit Endodontic Therapy

    Raju, T B V G; Seshadri, Abitha; Vamsipavani, B; Abhilash, K; Subhash, A V; Kumari, K.V Halini

    2014-01-01

    Background: The incidence of post-operative pain was compared following single-visit canal treatment in single- and multi-rooted teeth, with and without periapical radiolucency. The article also reviews the issues of postoperative pain and healing, following single-visit and multi-visit endodontic therapy. Single-visit endodontic therapy (SVE) was performed in 50 single-rooted teeth and 60 multiple-rooted teeth.

  13. The influence of single parenthood on the social needs of the single parent

    Dionysia F. Antonopoulou

    2012-01-01

    The changes occurring in the socio-economic situation in our country shape the environment that single - parent families experience. The treatment of single- parent families as a factor of economic and social development is a key objective in a state with a social character. AIM: The aim of this study was to research the phenomenon of single- parent families in Greece, and the effect of single parenthood on the social needs of the single parent. MATERIAL-METHOD: A specially designed, anonymou...

  14. NCBI nr-aa BLAST: CBRC-OPRI-01-0211 [SEVENS

    Full Text Available CBRC-OPRI-01-0211 ref|XP_740158.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85547.1| hypothetical protein PC403595.00.0 [Plasmodium chabaudi chabaudi] XP_740158.1 8e-21 45% ...

  15. NCBI nr-aa BLAST: CBRC-MDOM-11-0023 [SEVENS

    Full Text Available CBRC-MDOM-11-0023 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 3e-40 64% ...

  16. NCBI nr-aa BLAST: CBRC-MEUG-01-0601 [SEVENS

    Full Text Available CBRC-MEUG-01-0601 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 2e-29 51% ...

  17. NCBI nr-aa BLAST: CBRC-MDOM-03-0306 [SEVENS

    Full Text Available CBRC-MDOM-03-0306 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 5e-52 57% ...

  18. NCBI nr-aa BLAST: CBRC-PHAM-01-1543 [SEVENS

    Full Text Available CBRC-PHAM-01-1543 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-05 24% ...

  19. NCBI nr-aa BLAST: CBRC-PVAM-01-0839 [SEVENS

    Full Text Available CBRC-PVAM-01-0839 ref|XP_740158.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85547.1| hypothetical protein PC403595.00.0 [Plasmodium chabaudi chabaudi] XP_740158.1 5e-14 47% ...

  20. NCBI nr-aa BLAST: CBRC-MEUG-01-1314 [SEVENS

    Full Text Available CBRC-MEUG-01-1314 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-41 60% ...

  1. NCBI nr-aa BLAST: CBRC-MDOM-01-0513 [SEVENS

    Full Text Available CBRC-MDOM-01-0513 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-26 39% ...

  2. NCBI nr-aa BLAST: CBRC-MDOM-01-0072 [SEVENS

    Full Text Available CBRC-MDOM-01-0072 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 7e-57 57% ...

  3. NCBI nr-aa BLAST: CBRC-PVAM-01-1324 [SEVENS

    Full Text Available CBRC-PVAM-01-1324 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 1e-11 45% ...

  4. NCBI nr-aa BLAST: CBRC-MDOM-03-0287 [SEVENS

    Full Text Available CBRC-MDOM-03-0287 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 2e-23 49% ...

  5. NCBI nr-aa BLAST: CBRC-OPRI-01-1145 [SEVENS

    Full Text Available CBRC-OPRI-01-1145 ref|XP_740158.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85547.1| hypothetical protein PC403595.00.0 [Plasmodium chabaudi chabaudi] XP_740158.1 4e-19 43% ...

  6. NCBI nr-aa BLAST: CBRC-TTRU-01-0610 [SEVENS

    Full Text Available CBRC-TTRU-01-0610 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 0.016 25% ...

  7. NCBI nr-aa BLAST: CBRC-MEUG-01-2523 [SEVENS

    Full Text Available CBRC-MEUG-01-2523 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-16 33% ...

  8. NCBI nr-aa BLAST: CBRC-PVAM-01-0934 [SEVENS

    Full Text Available CBRC-PVAM-01-0934 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-37 52% ...

  9. NCBI nr-aa BLAST: CBRC-PHAM-01-1050 [SEVENS

    Full Text Available CBRC-PHAM-01-1050 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-08 36% ...

  10. NCBI nr-aa BLAST: CBRC-MDOM-06-0006 [SEVENS

    Full Text Available CBRC-MDOM-06-0006 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 1e-26 51% ...

  11. NCBI nr-aa BLAST: CBRC-TTRU-01-0662 [SEVENS

    Full Text Available CBRC-TTRU-01-0662 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 7e-04 26% ...

  12. NCBI nr-aa BLAST: CBRC-MDOM-04-0068 [SEVENS

    Full Text Available CBRC-MDOM-04-0068 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 6e-27 48% ...

  13. NCBI nr-aa BLAST: CBRC-OPRI-01-1422 [SEVENS

    Full Text Available CBRC-OPRI-01-1422 ref|XP_740158.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85547.1| hypothetical protein PC403595.00.0 [Plasmodium chabaudi chabaudi] XP_740158.1 2e-22 47% ...

  14. NCBI nr-aa BLAST: CBRC-MDOM-06-0140 [SEVENS

    Full Text Available CBRC-MDOM-06-0140 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 6e-33 43% ...

  15. NCBI nr-aa BLAST: CBRC-MDOM-06-0183 [SEVENS

    Full Text Available CBRC-MDOM-06-0183 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 8e-31 57% ...

  16. NCBI nr-aa BLAST: CBRC-PVAM-01-1373 [SEVENS

    Full Text Available CBRC-PVAM-01-1373 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 3e-46 52% ...

  17. NCBI nr-aa BLAST: CBRC-MDOM-03-0012 [SEVENS

    Full Text Available CBRC-MDOM-03-0012 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-43 60% ...

  18. NCBI nr-aa BLAST: CBRC-MDOM-06-0186 [SEVENS

    Full Text Available CBRC-MDOM-06-0186 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 8e-25 38% ...

  19. NCBI nr-aa BLAST: CBRC-MEUG-01-1761 [SEVENS

    Full Text Available CBRC-MEUG-01-1761 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 1e-31 51% ...

  20. NCBI nr-aa BLAST: CBRC-MDOM-01-0389 [SEVENS

    Full Text Available CBRC-MDOM-01-0389 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 3e-32 54% ...

  1. NCBI nr-aa BLAST: CBRC-MEUG-01-1167 [SEVENS

    Full Text Available CBRC-MEUG-01-1167 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 2e-29 60% ...

  2. NCBI nr-aa BLAST: CBRC-MDOM-08-0071 [SEVENS

    Full Text Available CBRC-MDOM-08-0071 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 9e-60 60% ...

  3. NCBI nr-aa BLAST: CBRC-MDOM-03-0387 [SEVENS

    Full Text Available CBRC-MDOM-03-0387 ref|XP_734055.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85114.1| hypothetical protein PC403034.00.0 [Plasmodium chabaudi chabaudi] XP_734055.1 0.002 47% ...

  4. NCBI nr-aa BLAST: CBRC-MDOM-03-0312 [SEVENS

    Full Text Available CBRC-MDOM-03-0312 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 5e-39 52% ...

  5. NCBI nr-aa BLAST: CBRC-MDOM-04-0421 [SEVENS

    Full Text Available CBRC-MDOM-04-0421 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-22 37% ...

  6. NCBI nr-aa BLAST: CBRC-MDOM-03-0392 [SEVENS

    Full Text Available CBRC-MDOM-03-0392 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-38 68% ...

  7. NCBI nr-aa BLAST: CBRC-MDOM-01-0542 [SEVENS

    Full Text Available CBRC-MDOM-01-0542 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 5e-49 59% ...

  8. NCBI nr-aa BLAST: CBRC-MDOM-05-0139 [SEVENS

    Full Text Available CBRC-MDOM-05-0139 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 8e-47 53% ...

  9. NCBI nr-aa BLAST: CBRC-MLUC-01-0121 [SEVENS

    Full Text Available CBRC-MLUC-01-0121 ref|XP_740158.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85547.1| hypothetical protein PC403595.00.0 [Plasmodium chabaudi chabaudi] XP_740158.1 4e-27 44% ...

  10. NCBI nr-aa BLAST: CBRC-VPAC-01-1208 [SEVENS

    Full Text Available CBRC-VPAC-01-1208 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 4e-19 32% ...

  11. NCBI nr-aa BLAST: CBRC-MDOM-06-0147 [SEVENS

    Full Text Available CBRC-MDOM-06-0147 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-34 48% ...

  12. NCBI nr-aa BLAST: CBRC-MDOM-03-0230 [SEVENS

    Full Text Available CBRC-MDOM-03-0230 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 3e-23 44% ...

  13. NCBI nr-aa BLAST: CBRC-MDOM-05-0028 [SEVENS

    Full Text Available CBRC-MDOM-05-0028 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 3e-19 36% ...

  14. NCBI nr-aa BLAST: CBRC-MDOM-03-0236 [SEVENS

    Full Text Available CBRC-MDOM-03-0236 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 4e-30 48% ...

  15. NCBI nr-aa BLAST: CBRC-MDOM-04-0214 [SEVENS

    Full Text Available CBRC-MDOM-04-0214 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 5e-42 53% ...

  16. NCBI nr-aa BLAST: CBRC-PHAM-01-1832 [SEVENS

    Full Text Available CBRC-PHAM-01-1832 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 5e-27 53% ...

  17. NCBI nr-aa BLAST: CBRC-MDOM-05-0084 [SEVENS

    Full Text Available CBRC-MDOM-05-0084 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 8e-24 38% ...

  18. NCBI nr-aa BLAST: CBRC-MDOM-04-0422 [SEVENS

    Full Text Available CBRC-MDOM-04-0422 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 5e-57 67% ...

  19. NCBI nr-aa BLAST: CBRC-MDOM-03-0060 [SEVENS

    Full Text Available CBRC-MDOM-03-0060 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-44 50% ...

  20. NCBI nr-aa BLAST: CBRC-OPRI-01-0074 [SEVENS

    Full Text Available CBRC-OPRI-01-0074 ref|XP_740158.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85547.1| hypothetical protein PC403595.00.0 [Plasmodium chabaudi chabaudi] XP_740158.1 9e-22 45% ...

  1. NCBI nr-aa BLAST: CBRC-MLUC-01-0289 [SEVENS

    Full Text Available CBRC-MLUC-01-0289 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-21 50% ...

  2. NCBI nr-aa BLAST: CBRC-MDOM-08-0070 [SEVENS

    Full Text Available CBRC-MDOM-08-0070 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-41 51% ...

  3. NCBI nr-aa BLAST: CBRC-MDOM-02-0013 [SEVENS

    Full Text Available CBRC-MDOM-02-0013 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 1e-28 50% ...

  4. NCBI nr-aa BLAST: CBRC-MDOM-09-0077 [SEVENS

    Full Text Available CBRC-MDOM-09-0077 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-20 37% ...

  5. NCBI nr-aa BLAST: CBRC-MDOM-05-0143 [SEVENS

    Full Text Available CBRC-MDOM-05-0143 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 5e-40 54% ...

  6. NCBI nr-aa BLAST: CBRC-PHAM-01-1870 [SEVENS

    Full Text Available CBRC-PHAM-01-1870 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 8e-27 44% ...

  7. NCBI nr-aa BLAST: CBRC-TTRU-01-1302 [SEVENS

    Full Text Available CBRC-TTRU-01-1302 ref|XP_740434.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH86963.1| hypothetical protein PC405176.00.0 [Plasmodium chabaudi chabaudi] XP_740434.1 0.010 25% ...

  8. NCBI nr-aa BLAST: CBRC-OPRI-01-1253 [SEVENS

    Full Text Available CBRC-OPRI-01-1253 ref|XP_740158.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85547.1| hypothetical protein PC403595.00.0 [Plasmodium chabaudi chabaudi] XP_740158.1 2e-22 46% ...

  9. NCBI nr-aa BLAST: CBRC-MDOM-03-0381 [SEVENS

    Full Text Available CBRC-MDOM-03-0381 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-44 51% ...

  10. NCBI nr-aa BLAST: CBRC-MDOM-02-0487 [SEVENS

    Full Text Available CBRC-MDOM-02-0487 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-17 37% ...

  11. NCBI nr-aa BLAST: CBRC-MDOM-01-0524 [SEVENS

    Full Text Available CBRC-MDOM-01-0524 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 5e-38 54% ...

  12. NCBI nr-aa BLAST: CBRC-OPRI-01-0484 [SEVENS

    Full Text Available CBRC-OPRI-01-0484 ref|XP_740158.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85547.1| hypothetical protein PC403595.00.0 [Plasmodium chabaudi chabaudi] XP_740158.1 1e-15 36% ...

  13. NCBI nr-aa BLAST: CBRC-TTRU-01-0062 [SEVENS

    Full Text Available CBRC-TTRU-01-0062 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 4e-18 42% ...

  14. NCBI nr-aa BLAST: CBRC-MDOM-03-0008 [SEVENS

    Full Text Available CBRC-MDOM-03-0008 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 6e-28 43% ...

  15. NCBI nr-aa BLAST: CBRC-MDOM-01-0060 [SEVENS

    Full Text Available CBRC-MDOM-01-0060 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 3e-20 45% ...

  16. NCBI nr-aa BLAST: CBRC-MDOM-01-0063 [SEVENS

    Full Text Available CBRC-MDOM-01-0063 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 4e-43 66% ...

  17. NCBI nr-aa BLAST: CBRC-MEUG-01-0720 [SEVENS

    Full Text Available CBRC-MEUG-01-0720 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 7e-50 58% ...

  18. NCBI nr-aa BLAST: CBRC-MDOM-01-0063 [SEVENS

    Full Text Available CBRC-MDOM-01-0063 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 7e-44 57% ...

  19. NCBI nr-aa BLAST: CBRC-MDOM-08-0112 [SEVENS

    Full Text Available CBRC-MDOM-08-0112 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 2e-35 56% ...

  20. NCBI nr-aa BLAST: CBRC-OPRI-01-0822 [SEVENS

    Full Text Available CBRC-OPRI-01-0822 ref|XP_740158.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85547.1| hypothetical protein PC403595.00.0 [Plasmodium chabaudi chabaudi] XP_740158.1 5e-21 47% ...

  1. NCBI nr-aa BLAST: CBRC-MDOM-09-0048 [SEVENS

    Full Text Available CBRC-MDOM-09-0048 ref|XP_734491.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH79466.1| hypothetical protein PC106124.00.0 [Plasmodium chabaudi chabaudi] XP_734491.1 2e-05 32% ...

  2. NCBI nr-aa BLAST: CBRC-MEUG-01-1883 [SEVENS

    Full Text Available CBRC-MEUG-01-1883 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-15 33% ...

  3. NCBI nr-aa BLAST: CBRC-MDOM-04-0483 [SEVENS

    Full Text Available CBRC-MDOM-04-0483 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 3e-44 50% ...

  4. NCBI nr-aa BLAST: CBRC-MDOM-03-0287 [SEVENS

    Full Text Available CBRC-MDOM-03-0287 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 4e-30 41% ...

  5. NCBI nr-aa BLAST: CBRC-MDOM-08-0081 [SEVENS

    Full Text Available CBRC-MDOM-08-0081 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 2e-34 60% ...

  6. NCBI nr-aa BLAST: CBRC-MDOM-08-0124 [SEVENS

    Full Text Available CBRC-MDOM-08-0124 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 3e-22 37% ...

  7. NCBI nr-aa BLAST: CBRC-MDOM-08-0069 [SEVENS

    Full Text Available CBRC-MDOM-08-0069 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 3e-34 52% ...

  8. NCBI nr-aa BLAST: CBRC-MDOM-01-0267 [SEVENS

    Full Text Available CBRC-MDOM-01-0267 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 4e-35 56% ...

  9. NCBI nr-aa BLAST: CBRC-MDOM-11-0023 [SEVENS

    Full Text Available CBRC-MDOM-11-0023 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-51 54% ...

  10. NCBI nr-aa BLAST: CBRC-MDOM-04-0228 [SEVENS

    Full Text Available CBRC-MDOM-04-0228 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 4e-15 40% ...

  11. NCBI nr-aa BLAST: CBRC-OPRI-01-0409 [SEVENS

    Full Text Available CBRC-OPRI-01-0409 ref|XP_736406.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH86683.1| hypothetical protein PC404847.00.0 [Plasmodium chabaudi chabaudi] XP_736406.1 1e-06 50% ...

  12. NCBI nr-aa BLAST: CBRC-MDOM-03-0132 [SEVENS

    Full Text Available CBRC-MDOM-03-0132 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-56 62% ...

  13. NCBI nr-aa BLAST: CBRC-MDOM-09-0076 [SEVENS

    Full Text Available CBRC-MDOM-09-0076 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 8e-22 32% ...

  14. NCBI nr-aa BLAST: CBRC-TTRU-01-0162 [SEVENS

    Full Text Available CBRC-TTRU-01-0162 ref|XP_745463.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH87248.1| hypothetical protein PC302387.00.0 [Plasmodium chabaudi chabaudi] XP_745463.1 0.18 28% ...

  15. NCBI nr-aa BLAST: CBRC-MDOM-01-0505 [SEVENS

    Full Text Available CBRC-MDOM-01-0505 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 2e-18 45% ...

  16. NCBI nr-aa BLAST: CBRC-MDOM-08-0194 [SEVENS

    Full Text Available CBRC-MDOM-08-0194 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-28 41% ...

  17. NCBI nr-aa BLAST: CBRC-OPRI-01-0136 [SEVENS

    Full Text Available CBRC-OPRI-01-0136 ref|XP_736406.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH86683.1| hypothetical protein PC404847.00.0 [Plasmodium chabaudi chabaudi] XP_736406.1 4e-07 52% ...

  18. NCBI nr-aa BLAST: CBRC-MDOM-06-0183 [SEVENS

    Full Text Available CBRC-MDOM-06-0183 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-40 52% ...

  19. NCBI nr-aa BLAST: CBRC-MDOM-04-0031 [SEVENS

    Full Text Available CBRC-MDOM-04-0031 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 2e-34 58% ...

  20. NCBI nr-aa BLAST: CBRC-MDOM-02-0422 [SEVENS

    Full Text Available CBRC-MDOM-02-0422 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-27 47% ...

  1. NCBI nr-aa BLAST: CBRC-MDOM-04-0455 [SEVENS

    Full Text Available CBRC-MDOM-04-0455 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-40 58% ...

  2. NCBI nr-aa BLAST: CBRC-MDOM-08-0249 [SEVENS

    Full Text Available CBRC-MDOM-08-0249 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 9e-19 33% ...

  3. NCBI nr-aa BLAST: CBRC-MDOM-03-0133 [SEVENS

    Full Text Available CBRC-MDOM-03-0133 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 3e-16 40% ...

  4. NCBI nr-aa BLAST: CBRC-GGOR-01-1464 [SEVENS

    Full Text Available CBRC-GGOR-01-1464 ref|XP_734491.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH79466.1| hypothetical protein PC106124.00.0 [Plasmodium chabaudi chabaudi] XP_734491.1 4e-05 31% ...

  5. NCBI nr-aa BLAST: CBRC-MDOM-05-0451 [SEVENS

    Full Text Available CBRC-MDOM-05-0451 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-46 52% ...

  6. NCBI nr-aa BLAST: CBRC-MEUG-01-0601 [SEVENS

    Full Text Available CBRC-MEUG-01-0601 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 1e-39 44% ...

  7. NCBI nr-aa BLAST: CBRC-PHAM-01-1704 [SEVENS

    Full Text Available CBRC-PHAM-01-1704 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 3e-44 54% ...

  8. NCBI nr-aa BLAST: CBRC-MDOM-07-0138 [SEVENS

    Full Text Available CBRC-MDOM-07-0138 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-16 34% ...

  9. NCBI nr-aa BLAST: CBRC-MEUG-01-2619 [SEVENS

    Full Text Available CBRC-MEUG-01-2619 ref|XP_732422.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH85273.1| hypothetical protein PC403258.00.0 [Plasmodium chabaudi chabaudi] XP_732422.1 4e-15 36% ...

  10. NCBI nr-aa BLAST: CBRC-MDOM-09-0085 [SEVENS

    Full Text Available CBRC-MDOM-09-0085 ref|XP_738775.1| hypothetical protein [Plasmodium chabaudi chabaudi...] emb|CAH83762.1| hypothetical protein PC401526.00.0 [Plasmodium chabaudi chabaudi] XP_738775.1 2e-27 35% ...

  11. Mechanisms of single bubble cleaning.

    Reuter, Fabian; Mettin, Robert

    2016-03-01

    The dynamics of collapsing bubbles close to a flat solid is investigated with respect to its potential for removal of surface attached particles. Individual bubbles are created by nanosecond Nd:YAG laser pulses focused into water close to glass plates contaminated with melamine resin micro-particles. The bubble dynamics is analysed by means of synchronous high-speed recordings. Due to the close solid boundary, the bubble collapses with the well-known liquid jet phenomenon. Subsequent microscopic inspection of the substrates reveals circular areas clean of particles after a single bubble generation and collapse event. The detailed bubble dynamics, as well as the cleaned area size, is characterised by the non-dimensional bubble stand-off γ=d/Rmax, with d: laser focus distance to the solid boundary, and Rmax: maximum bubble radius before collapse. We observe a maximum of clean area at γ≈0.7, a roughly linear decay of the cleaned circle radius for increasing γ, and no cleaning for γ>3.5. As the main mechanism for particle removal, rapid flows at the boundary are identified. Three different cleaning regimes are discussed in relation to γ: (I) For large stand-off, 1.8flows touch down onto the substrate and remove particles without significant contact of the gas phase. (II) For small distances, γflows at the substrate are driven by the jet impact with its subsequent radial spreading, and by the liquid following the motion of the collapsing and rebounding bubble wall. Both flows remove particles. Their relative timing, which depends sensitively on the exact γ, appears to determine the extension of the area with forces large enough to cause particle detachment. (III) At intermediate stand-off, 1.1cleaning mechanisms similar to an effective small γ collapse: particles are removed by the jet flow and the flow induced by the bubble wall oscillation. Furthermore, the observations reveal that the extent of direct bubble gas phase contact to the solid is partially

  12. Model protocells from single-chain lipids.

    Mansy, Sheref S

    2009-03-01

    Significant progress has been made in the construction of laboratory models of protocells. Most frequently the developed vesicle systems utilize single-chain lipids rather than the double-chain lipids typically found in biological membranes. Although single-chain lipids yield less robust vesicles, their dynamic characteristics are highly exploitable for protocellular functions. Herein the advantages of using single-chain lipids in the construction of protocells are discussed. PMID:19399223

  13. Single photon response of photomultiplier tubes

    Beta or gamma rays, when directly incident on the window of an optically shielded photomultiplier tube, yield a typical single photon spectrum. The single photons are possibly generated in the glass window of the photomultiplier tube through excitation of atoms in glass by electrons. The coincidence resolving time has also been measured with a 60Co gamma source and a pair of optically shielded photomultiplier tubes detecting single photons. (orig.)

  14. Gambaran Kepuasan Berwirausaha pada Wanita Single Mother

    Jamilah, Siti

    2014-01-01

    In general, the financial situation of a single mother less than adequate to fill their needs than when they have a husband. Entrepreneurship may be an option for single mother to fill their needs. When entrepreneur can handle the business they want smoothly and properly, they will feel the satisfaction on entrepreneurship. However, from the facts found in the literature and field study, there were some differences in the satisfaction of entrepreneurship on single mothers because of several t...

  15. Making "Operations" inside a Single Molecule

    2005-01-01

    @@ Free and delicate manipulation of single molecules has long been expected by scientists so as to realize specific functions. In the 1990s, the laboratory led by Prof. Wison Ho from the University of California was successful in inducing chemical reactions at the single molecule level with scanning tunneling microscopy (STM), revealing the extensive potentials of "single molecule operation." However, until recently, researchers have failed to utilize the reaction to give rise to special physical properties.

  16. Microfluidics for investigating single-cell biodynamics

    Cookson, Scott Warren

    2008-01-01

    Progress in synthetic biology requires the development of novel techniques for investigating long-term dynamics in single cells. Here, we demonstrate the utility of microfluidics for investigating single-cell biodynamics within tightly-controlled environments in the model organisms Saccharomyces cerevisiae and Escherichia coli. First, we develop a microfluidic chemostat for monitoring single-cell gene expression within large populations of S. cerevisiae over many cellular generations. We over...

  17. Ideologies of motherhood and single mothers

    O'Hagan, Clare

    2006-01-01

    This chapter examines the situation of lone parents in contemporay Ireland, in particular the workings of ideologies of motherhood and the family through different sites, contexts and institutions in order to determine the impact of these ideologies on single mothers' lives. Specifically, the number of single mothers, ideologies of motherhood and the family, the influence of Church, State and New Right and Irish social policy are examined, and their combined impact on Irish single mothers is ...

  18. Single parenthood in the government welfare system

    EWA JURCZYK-ROMANOWSKA

    2011-01-01

    Reflections on the subject of government welfare system aimed at single parents are presented in the article. Changes of civilisation are a cause of an escalation of the phenomenon of single parenthood in Poland, with the number of divorces rising year by year and an increase in the number of people who decide to live in concubinates or become single parents of children born out of wedlock. The withdrawal of the government from numerous forms of support for that social group is...

  19. Unparticle physics in single top signals

    Alan, A. T.; Pak, N. K.; Senol, A.

    2008-07-01

    We study the single production of top quarks in e+e-, ep and pp collisions in the context of unparticle physics through the Flavor Violating (FV) unparticle vertices and compute the total cross-sections for single top production as functions of scale dimension d_{{\\cal U}} . We find that among all, LHC is the most promising facility to probe the unparticle physics via single top quark production processes.

  20. Unparticle Physics in Single Top Signals

    Alan, A T; Senol, A

    2007-01-01

    We study the single production of top quarks in $e^+e^-, ep$ and $pp$ collisions in the context of unparticle physics through the Flavor Violating (FV) unparticle vertices and compute the total cross sections for single top production as functions of scale dimension $d_{\\U}$. We find that among all, LHC is the most promising facility to probe the unparticle physics via single top quark production processes.

  1. Model Protocells from Single-Chain Lipids

    Mansy, Sheref S.

    2009-01-01

    Significant progress has been made in the construction of laboratory models of protocells. Most frequently the developed vesicle systems utilize single-chain lipids rather than the double-chain lipids typically found in biological membranes. Although single-chain lipids yield less robust vesicles, their dynamic characteristics are highly exploitable for protocellular functions. Herein the advantages of using single-chain lipids in the construction of protocells are discussed.

  2. Model Protocells from Single-Chain Lipids

    Sheref S. Mansy

    2009-03-01

    Full Text Available Significant progress has been made in the construction of laboratory models of protocells. Most frequently the developed vesicle systems utilize single-chain lipids rather than the double-chain lipids typically found in biological membranes. Although single-chain lipids yield less robust vesicles, their dynamic characteristics are highly exploitable for protocellular functions. Herein the advantages of using single-chain lipids in the construction of protocells are discussed.

  3. Assessing The Single-Parent Family

    Christie-Seely, Janet; Talbot, Yves

    1985-01-01

    The increase of single-parent families causes an increase in psychosocial problems and illness associated with stress. Divorce, separation, and lone parenting have now surpassed death as a cause of single-parent families. They are major life events, and the family physician who helps anticipate them and facilitates adaptation of the family can help prevent associated morbidity and mortality. A non-judgmental approach and understanding of system theory helps in assessing the single-parent fami...

  4. Single Top Physics at ATLAS and CMS

    zur Nedden, Martin; The ATLAS collaboration

    2016-01-01

    A summary over the single top analyses in the ATLAS and CMS experiments is given. In this talk, the measurements of the single top cross sections in the t-channel, the Wt-channel and the s-channel are shown as the basis for a rich physics program with single top quarks. After discussing also the differential and fiducial cross sections and the V_tb properties, the single-top analyses are used as the bases for searches for physics beyond the Standard Model. Searches for Mono-tops, Flavour Changing Neutral Currents and anomalous couplings are discussed.

  5. Single-molecule pulling: phenomenology and interpretation

    Franco, Ignacio; Schatz, George C

    2012-01-01

    Single-molecule pulling techniques have emerged as versatile tools for probing the noncovalent forces holding together the secondary and tertiary structure of macromolecules. They also constitute a way to study at the single-molecule level processes that are familiar from our macroscopic thermodynamic experience. In this Chapter, we summarize the essential phenomenology that is typically observed during single-molecule pulling, provide a general statistical mechanical framework for the interpretation of the equilibrium force spectroscopy and illustrate how to simulate single-molecule pulling experiments using molecular dynamics.

  6. Single and multiband THz Metamaterial Polarizers

    Sangala, Bagvanth Reddy; Deshmukh, Prathmesh; Surdi, Harshad; Rana, Goutam; Gopal, Achanta Venu; Prabhu, S S

    2015-01-01

    We report single and multiband linear polarizers for terahertz (THz) frequencies using cut-wire metamaterials (MM). The MMs are designed by finite element method, fabricated by electron beam lithography, and characterized by THz time-domain spectroscopy. The MM unit cells consist of single or multiple length cut-wire pads of gold on semi-insulating Gallium Arsenide for single or multiple band polarizers. The dependence of the resonance frequency of the single band polarizer on the length of the cut-wires is explained based a transmission line model.

  7. Analysis Of Single Phase Matrix Converter

    Divya Ahirrao

    2014-03-01

    Full Text Available This paper presents concept of single phase matrix converter. Single phase matrix converter (SPMC performs a function such as frequency changer, rectifier, inverter; chopper. This reduces the need for new converter hardware. Pulse width modulation (SPWM techniques are used to calculate the switch duty ratio to synthesis the output. The simulation of converter is carried out in MATLAB/SIMULINK. Hardware design is obtained using readily available IC‟s and other components. This paper discusses the new multiple converter for single phase input using matrix topology using just a single control logic.

  8. Single top quark production with CMS

    Piccolo Davide

    2013-11-01

    Full Text Available Measurements of single top quark production performed using the CMS experiment [1] data collected in 2011 at centre-of-mass energies of 7 TeV and in 2012 at 8 TeV, are presented. The cross sections for the electroweak production of single top quarks in the t-channel and in association with W-bosons is measured and the results are used to place constraints on the CKM matrix element Vtb. Measurements of top quark properties in single top quark production are also presented. The results include the measurement of the charge ratio in the single top t-channel.

  9. Search for Single Top Production at LEP

    Achard, P; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Anderhub, H; Andreev, V P; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, G; Baksay, L; Baldew, S V; Banerjee, S; Banerjee, Sw; Barczyk, A; Barillère, R; Bartalini, P; Basile, M; Batalova, N; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biglietti, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böhm, A; Boldizsar, L; Borgia, B; Bottai, S; Bourilkov, D; Bourquin, Maurice; Braccini, S; Branson, J G; Brochu, F; Burger, J D; Burger, W J; Cai, X D; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A M; Casaus, J; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada, M; Chamizo-Llatas, M; Chang, Y H; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, Luisa; Cindolo, F; Clare, I; Clare, R; Coignet, G; Colino, N; Costantini, S; de la Cruz, B; Cucciarelli, S; van Dalen, J A; De Asmundis, R; Déglon, P L; Debreczeni, J; Degré, A; Dehmelt, K; Deiters, K; Della Volpe, D; Delmeire, E; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Dierckxsens, M; Dionisi, C; Dittmar, M; Doria, A; Dova, M T; Duchesneau, D; Echenard, B; Eline, A; El-Mamouni, H; Engler, A; Eppling, F J; Ewers, A; Extermann, P; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, M; Ferguson, T; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Fisher, W; Fisk, I; Forconi, G; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gentile, S; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; van Gulik, R; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hakobyan, R S; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hirschfelder, J; Hofer, H; Hohlmann, M; Holzner, G; Hou, S R; Hu, Y; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Käfer, D; Kaur, M; Kienzle-Focacci, M N; Kim, J K; Kirkby, Jasper; Kittel, E W; Klimentov, A; König, A C; Kopal, M; Koutsenko, V F; Kräber, M H; Krämer, R W; Krenz, W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Le Goff, J M; Leiste, R; Levtchenko, M; Levchenko, P M; Li, C; Likhoded, S A; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Lübelsmeyer, K; Luci, C; Luminari, L; Lustermann, W; Ma Wen Gan; Malgeri, L; Malinin, A; Maña, C; Mangeol, D J J; Mans, J; Martin, J P; Marzano, F; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Muanza, G S; Muijs, A J M; Musicar, B; Musy, M; Nagy, S; Natale, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Niessen, T; Nisati, A; Nowak, H; Ofierzynski, R A; Organtini, G; Palomares, C; Pandoulas, D; Paolucci, P; Paramatti, R; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pedace, M; Pensotti, S; Perret-Gallix, D; Petersen, B; Piccolo, D; Pierella, F; Pioppi, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Pothier, J; Prokofiev, D O; Prokofev, D; Quartieri, J; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Ranieri, R; Raspereza, A V; Razis, P A; Ren, D; Rescigno, M; Reucroft, S; Riemann, S; Riles, K; Roe, B P; Romero, L; Rosca, A; Rosier-Lees, S; Roth, S; Rosenbleck, C; Roux, B; Rubio, Juan Antonio; Ruggiero, G; Rykaczewski, H; Sakharov, A; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Sanders, M P; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schopper, Herwig Franz; Schotanus, D J; Schwering, G; Sciacca, C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Souga, C; Spillantini, P; Steuer, M; Stickland, D P; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Sushkov, S V; Suter, H; Swain, J D; Szillási, Z; Tang, X W; Tarjan, P; Tauscher, Ludwig; Taylor, L; Tellili, B; Teyssier, D; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Ulbricht, J; Valente, E; Van de Walle, R T; Vásquez, R P; Veszpremi, V; Vesztergombi, G; Vetlitskii, I; Vicinanza, D; Viertel, Gert M; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Wadhwa, M; Wallraff, W; Wang, X L; Wang, Z M; Weber, M; Wienemann, P; Wilkens, H; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhao, J; Zhu, G Y; Zhu, R Y; Zhuang, H L; Zichichi, A; Zimmermann, B; Zöller, M

    2002-01-01

    Single top production in e^+e^- annihilations is searched for in data collected by the L3 detector at centre-of-mass energies from 189 to 209 GeV, corresponding to a total integrated luminosity of 634 pb-1. Investigating hadronic and semileptonic top decays, no evidence of single top production at LEP is obtained and upper limits on the single top cross section as a function of the centre-of-mass energy are derived. Limits on possible anomalous couplings, as well as on the scale of contact interactions responsible for single top production are determined.

  10. Single Chromatin Fibre Assembly Using Optical Tweezers

    Bennink, M.L.; Pope, L.H.; Leuba, S.H.; Grooth, de B.G.; Greve, J.

    2001-01-01

    Here we observe the formation of a single chromatin fibre using optical tweezers. A single -DNA molecule was suspended between two micron-sized beads, one held by a micropipette and the other in an optical trap. The constrained DNA molecule was incubated with Xenopus laevis egg extract in order to r

  11. Economic Aspects of Single Parenthood in Chicago.

    Sander, William

    1985-01-01

    Estimated single parenthood rates in Chicago in 1970 and 1980. Single parenthood was related to both low earning ability and very high earning ability. The former was affected by low educational levels and high unemployment. The latter was caused by an increase in women's earning ability. (BH)

  12. Single-Gender Education: Educators' Perspective

    Fry, John P.

    2009-01-01

    The examination of educator's views regarding single-gender education was the basis of this study. The significance of the intended study is to show the educator's view of single-gender education as it relates to student academic achievement and behavioral incidents. A quantitative study was conducted utilizing a sample population of regular and…

  13. Experience with single-layer rectal anastomosis.

    Khubchandani, M; Upson, J

    1981-01-01

    Anastomotic dehiscence following resection of the large intestine is a serious complication. Satisfactory results of single-layer anastomosis depend upon meticulous technique and a scrupulously clean colon. Out of 65 single-layer anastomoses involving the rectum, significant leakage occurred in 4 patients. The results are reported in order to draw attention to the safety and efficacy of one-layer anastomosis.

  14. Solving Single-digit Sudoku Subproblems

    Eppstein, David

    2012-01-01

    We show that single-digit "Nishio" subproblems in nxn Sudoku puzzles may be solved in time o(2^n), faster than previous solutions such as the pattern overlay method. We also show that single-digit deduction in Sudoku is NP-hard.

  15. Single-Sex Schooling and Women's Education.

    Bauch, Patricia A.

    Rarely when single-sex Catholic secondary schools convert to coed school organization is the potential loss of gender-specific benefits addressed. Since the movement to coeducation is seldom accompanied by the return of a "converted" school to single-sex status, the incalculable loss to the traditional gender diversity of school organization is…

  16. Single-Level and Multilevel Mediation Analysis

    Tofighi, Davood; Thoemmes, Felix

    2014-01-01

    Mediation analysis is a statistical approach used to examine how the effect of an independent variable on an outcome is transmitted through an intervening variable (mediator). In this article, we provide a gentle introduction to single-level and multilevel mediation analyses. Using single-level data, we demonstrate an application of structural…

  17. The single backscattering of gamma rays

    The paper presents the results of the single backscattering investigations of gamma rays in various materials. A simplified mathematical model is given for determining the probability that a photon scattered back by a single Compton scattering is incident on the detector. The probability is calculated as a function of the primary photon energy and the atomic number Z of the scatterer. (Auth.)

  18. Single Parent Families: Diversity, Myths and Realities.

    Hanson, Shirley M. H., Ed.; And Others

    Major changes are taking place in western families which affect the way professionals interact with families. Drawing on a multidisciplinary team of scholars, this book presents a synthesis of the demographic, theoretical, and research data on the various permutations of the single parent family. Topics include economics, single custodial or…

  19. Single Adoptive Mothers and Their Children

    Dougherty, Sharon Ann

    1978-01-01

    In view of the increasing number of single women who adopt children, the social work profession has an obligation to learn more about this group of mothers. This article is based on a research study to identify characteristics of single adoptive mothers and their children and to learn what community supports the mothers believe would be helpful.…

  20. Improving the Single Scalar Consistency Relation

    Brooker, D J; Woodard, R P

    2016-01-01

    We propose a test of single-scalar inflation based on using the well-measured scalar power spectrum to reconstruct the tensor power spectrum, up to a single integration constant. This sort of test can be used effectively, even when the tensor power spectrum is measured too poorly to resolve the tensor spectral index.

  1. Integrated Electrowetting Nanoinjector for Single Cell Transfection

    Elaheh Shekaramiz; Ganeshkumar Varadarajalu; Day, Philip J.; Kumar Wickramasinghe, H.

    2016-01-01

    Single cell transfection techniques are essential to understand the heterogeneity between cells. We have developed an integrated electrowetting nanoinjector (INENI) to transfect single cells. The high transfection efficiency, controlled dosage delivery and ease of INENI fabrication promote the widespread application of the INENI in cell transfection assays.

  2. Simple microcavity for single-photon generation.

    Plakhotnik, Taras

    2005-04-18

    A new design of an optical resonator for generation of single-photon pulses is proposed. The resonator is made of a cylindrical or spherical piece of a polymer squeezed between two flat dielectric mirrors. The mode characteristics of this resonator are calculated numerically. The numerical analysis is backed by a physical explanation. The decay time and the mode volume of the fundamental mode are sufficient for achieving more than 96% probability of generating a single-photon in a single-mode. The corresponding requirement for the reflectivity of the mirrors (~99.9%) and the losses in the polymer (100 dB/m) are quite modest. The resonator is suitable for single-photon generation based on optical pumping of a single quantum system such as an organic molecule, a diamond nanocrystal, or a semiconductor quantum dot if they are imbedded in the polymer. PMID:19495201

  3. Chemical principles of single-molecule electronics

    Su, Timothy A.; Neupane, Madhav; Steigerwald, Michael L.; Venkataraman, Latha; Nuckolls, Colin

    2016-03-01

    The field of single-molecule electronics harnesses expertise from engineering, physics and chemistry to realize circuit elements at the limit of miniaturization; it is a subfield of nanoelectronics in which the electronic components are single molecules. In this Review, we survey the field from a chemical perspective and discuss the structure-property relationships of the three components that form a single-molecule junction: the anchor, the electrode and the molecular bridge. The spatial orientation and electronic coupling between each component profoundly affect the conductance properties and functions of the single-molecule device. We describe the design principles of the anchor group, the influence of the electronic configuration of the electrode and the effect of manipulating the structure of the molecular backbone and of its substituent groups. We discuss single-molecule conductance switches as well as the phenomenon of quantum interference and then trace their fundamental roots back to chemical principles.

  4. Microorganism characterization by single particle mass spectrometry.

    Russell, Scott C

    2009-01-01

    In recent years a major effort by several groups has been undertaken to identify bacteria by mass spectrometry at the single cell level. The intent of this review is to highlight the recent progress made in the application of single particle mass spectrometry to the analysis of microorganisms. A large portion of the review highlights improvements in the ionization and mass analysis of bio-aerosols, or particles that contain biologically relevant molecules such as peptides or proteins. While these are not direct applications to bacteria, the results have been central to a progression toward single cell mass spectrometry. Developments in single particle matrix-assisted laser desorption/ionization (MALDI) are summarized. Recent applications of aerosol laser desorption/ionization (LDI) to the analysis of single microorganisms are highlighted. Successful applications of off-line and on-the-fly aerosol MALDI to microorganism detection are discussed. Limitations to current approaches and necessary future achievements are also addressed. PMID:18949817

  5. Extracting Models in Single Molecule Experiments

    Presse, Steve

    2013-03-01

    Single molecule experiments can now monitor the journey of a protein from its assembly near a ribosome to its proteolytic demise. Ideally all single molecule data should be self-explanatory. However data originating from single molecule experiments is particularly challenging to interpret on account of fluctuations and noise at such small scales. Realistically, basic understanding comes from models carefully extracted from the noisy data. Statistical mechanics, and maximum entropy in particular, provide a powerful framework for accomplishing this task in a principled fashion. Here I will discuss our work in extracting conformational memory from single molecule force spectroscopy experiments on large biomolecules. One clear advantage of this method is that we let the data tend towards the correct model, we do not fit the data. I will show that the dynamical model of the single molecule dynamics which emerges from this analysis is often more textured and complex than could otherwise come from fitting the data to a pre-conceived model.

  6. Single-incision total laparoscopic hysterectomy

    Sinha Rakesh

    2011-01-01

    Full Text Available Single-incision laparoscopic surgery is an alternative to conventional multiport laparoscopy. Single-access laparoscopy using a transumbilical port affords maximum cosmetic benefits because the surgical incision is hidden in the umbilicus. The advantages of single-access laparoscopic surgery may include less bleeding, infection, and hernia formation and better cosmetic outcome and less pain. The disadvantages and limitations include longer surgery time, difficulty in learning the technique, and the need for specialized instruments. Ongoing refinement of the surgical technique and instrumentation is likely to expand its role in gynecologic surgery in the future. We perform single-incision total laparoscopic hysterectomy using three ports in the single transumbilical incision.

  7. Structure and interactions of a malarial vaccine candidate, AMA1, form the parasite plasmodium falciparum

    Full text: Apical membrane antigen 1 (AMA1), a merozoite surface protein found in all species of Plasmodium and other apicomplexan parasites, is a strong candidate for inclusion in a malarial vaccine. Recombinant AMA1 protected against P. fragile in monkeys and P. chabaudi adami in mice. P. falciparum AMA1 which has a 62-kDa ectodomain consisting of three disulphide-stabilised domains, is a target of antibodies that inhibit merozoite invasion in vitro. Here we describe the solution structure of domain III (14 kDa), determined by NMR on 15N- and 13C/15N-labelled samples. It has a well-defined disulphide-stabilised core interrupted by a disordered loop, and both the N- and C-terminal regions of the molecule are unstructured. The structured region includes all three disulphide bonds. Naturally-occurring mutations across 11 different P falciparum strains that are located far apart in the sequence cluster around the disulphide core in the 3D structure of domain III, suggesting that this region contains the major epitopes recognised by neutralising antibodies. Consistent with this, the disulphide-bond stabilised conformation of the ectodomain was essential for protection, as the antigen was not an effective vaccine after reduction and alkylation. Peptides have been found by phage display that bind to AMA1 and block merozoite invasion of erythrocytes. We have investigated their solution structures and interaction with full-length AMA1 ectodomain in an effort to understand the structure-function relationships of this important vaccine candidate

  8. Coherent single-photon absorption by single emitters coupled to 1D nanophotonic waveguides

    Chen, Yuntian; Wubs, Martijn; Mørk, Jesper;

    2012-01-01

    We have derived an efficient model that allows calculating the dynamical single-photon absorption of an emitter coupled to a waveguide. We suggest a novel and simple structure that leads to strong single-photon absorption.......We have derived an efficient model that allows calculating the dynamical single-photon absorption of an emitter coupled to a waveguide. We suggest a novel and simple structure that leads to strong single-photon absorption....

  9. Coherent single-photon absorption by single emitters coupled to one-dimensional nanophotonic waveguides

    Chen, Yuntian; Wubs, Martijn; Mørk, Jesper; Koenderink, A. Femius

    2011-01-01

    We study the dynamics of single-photon absorption by a single emitter coupled to a one-dimensional waveguide that simultaneously provides channels for spontaneous emission (SE) decay and a channel for the input photon. We have developed a time-dependent theory that allows us to specify any input ...... can be improved by a further 4% by engineering the dispersion. Efficient single-photon absorption by a single emitter has potential applications in quantum communication and quantum computation....

  10. Postsecondary Education and Economic Well-Being of Single Mothers and Single Fathers

    Zhan, Min; Pandey, Shanta

    2004-01-01

    We investigate the effects of post-secondary education on the economic well-being of single parents. The data for this study are from the 1993 Panel Study of Income Dynamics, with a sample of 930 single mothers and 168 single fathers. The results indicate that post-secondary education, particularly a 4-year college degree, improves the economic…

  11. A Single Father's Shopping Bag: Purchasing Decisions in Single-Father Families

    Ziol-Guest, Kathleen M.

    2009-01-01

    Using data from the 1980 to 2003 panels of the Consumer Expenditure Survey, this article examines purchasing decisions in father-headed single-parent families. Single-father expenditures are compared to both married-parent expenditures and single-mother expenditures on 17 broad categories of household-level goods and services. Multivariate…

  12. Single-atom conductance of Y

    Parveen, Nadia; Ishino, Yuji; Kurokawa, Shu; Sakai, Akira

    2016-05-01

    Y is a trivalent metal like Al but has one d valence electron instead of one p valence electron in Al. This makes a single-atom contact of Y a suitable playground for investigating how d valence electrons contribute to the single-atom conductance. In this paper, we present the results of our theoretical and experimental studies of the single-atom conductance of Y. We carried out conductance measurements on Y contacts and found that the conductance histogram observed at 4 K exhibits a single broad peak at 1.9G0. We also calculated the electron transmission through a Y single-atom contact and obtained the total transmission 1.75 at the Fermi level. Both our theoretical and experimental findings consistently indicate that the single-atom conductance of Y lies at (1.8 - 1.9)G0, which is nearly twice as high as that of Al. This increase in the single-atom conductance is due to the second and the third eigenchannels of Y which accomplish higher transmission compared to those of Al. We found that the difference in the contours of sd- and sp-eigenchannels can account for the higher transmission of the sd-eigenchannels.

  13. Single charge detection in capacitively coupled integrated single electron transistors based on single-walled carbon nanotubes

    Zhou, Xin; Ishibashi, Koji

    2012-09-01

    Single charge detection is demonstrated in the capacitively coupled integrated single electron transistors (SETs) in single-walled carbon nanotubes (SWCNTs) quantum dots. Two SETs are fabricated based on two different SWCNTs aligned in parallel, by taking advantage of the aligned growth of SWCNTs and subsequent transfer-printed techniques. In order to make both two SETs be capacitively coupled, a metal finger is fabricated on the top of them. The charge sensing is proved by the response of a detector current in one SWCNT-SET when the number of electrons in the other SWCNT-SET is changed by sweeping the corresponding gate voltages. In this integrated device, shifts of Coulomb oscillation peaks due to the single electron event are also observed.

  14. Thermally activated, single component epoxy systems

    Unruh, David A.

    2011-08-23

    A single component epoxy system in which the resin and hardener components found in many two-component epoxies are combined onto the same molecule is described. The single molecule precursor to the epoxy resin contains both multiple epoxide moieties and a diamine held latent by thermally degradable carbamate linkages. These bis-carbamate "single molecule epoxies" have an essentially infinite shelf life and access a significant range in curing temperatures related to the structure of the carbamate linkages used. © 2011 American Chemical Society.

  15. Generation of single plasma channel in air

    The conditions of generating a single plasma channel in air are studied by using picosecond and femtosecond laser pulse. A stable and single plasma channel can be generated by a picosecond laser pulse with energy of 8-12 mJ and focusing length of 15 cm. The self-generated light emission is observed to be confined in the plasma channel and propagates in the channel. When using short focal length lenses it is easy to generate a single plasma channel in air with femtosecond laser with energy less than 10 mJ. (authors)

  16. Single-instruction multiple-data execution

    Hughes, Christopher J

    2015-01-01

    Having hit power limitations to even more aggressive out-of-order execution in processor cores, many architects in the past decade have turned to single-instruction-multiple-data (SIMD) execution to increase single-threaded performance. SIMD execution, or having a single instruction drive execution of an identical operation on multiple data items, was already well established as a technique to efficiently exploit data parallelism. Furthermore, support for it was already included in many commodity processors. However, in the past decade, SIMD execution has seen a dramatic increase in the set of

  17. SPM analysis of single aerosol particles

    Aerosol samples were collected using Anderson cascade impact samplers and the dispersed single aerosol particles were embedded in thin PVDF films. A group of single aerosol particles distributed in an area of 180 μm x 150 μm was analyzed by the scanning proton microprobe (SPM). The distributions of 12 elements in the group were mapped with the three dimensional contour technique. Air pollution sources were then analyzed in some details. It is shown that analysis of the group of single aerosol particles by SPM may become a new approach to the study of air pollution

  18. Automated Single Cell Data Decontamination Pipeline

    Tennessen, Kristin [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Pati, Amrita [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.

    2014-03-21

    Recent technological advancements in single-cell genomics have encouraged the classification and functional assessment of microorganisms from a wide span of the biospheres phylogeny.1,2 Environmental processes of interest to the DOE, such as bioremediation and carbon cycling, can be elucidated through the genomic lens of these unculturable microbes. However, contamination can occur at various stages of the single-cell sequencing process. Contaminated data can lead to wasted time and effort on meaningless analyses, inaccurate or erroneous conclusions, and pollution of public databases. A fully automated decontamination tool is necessary to prevent these instances and increase the throughput of the single-cell sequencing process

  19. Absorption imaging of a single atom

    Streed, E. W.; Jechow, A.; Norton, B. G.; Kielpinski, D.

    2012-01-01

    Absorption imaging has played a key role in the advancement of science from van Leeuwenhoek's discovery of red blood cells to modern observations of dust clouds in stellar nebulas and Bose-Einstein condensates. Here we show the first absorption imaging of a single atom isolated in vacuum. The optical properties of atoms are thoroughly understood, so a single atom is an ideal system for testing the limits of absorption imaging. A single atomic ion was confined in an RF Paul trap and the absorp...

  20. Relaxor-PT Single Crystal Piezoelectric Sensors

    Xiaoning Jiang

    2014-07-01

    Full Text Available Relaxor-PbTiO3 piezoelectric single crystals have been widely used in a broad range of electromechanical devices, including piezoelectric sensors, actuators, and transducers. This paper reviews the unique properties of these single crystals for piezoelectric sensors. Design, fabrication and characterization of various relaxor-PT single crystal piezoelectric sensors and their applications are presented and compared with their piezoelectric ceramic counterparts. Newly applicable fields and future trends of relaxor-PT sensors are also suggested in this review paper.

  1. Single-cell technologies in environmental omics

    Kodzius, Rimantas

    2015-10-22

    Environmental studies are primarily done by culturing isolated microorganisms or by amplifying and sequencing conserved genes. Difficulties understanding the complexity of large numbers of various microorganisms in an environment led to the development of techniques to enrich specific microorganisms for upstream analysis, ultimately leading to single-cell isolation and analyses. We discuss the significance of single-cell technologies in omics studies with focus on metagenomics and metatranscriptomics. We propose that by reducing sample heterogeneity using single-cell genomics, metaomic studies can be simplified.

  2. Single Top Quark Production at the Tevatron

    Peters, Yvonne

    2012-01-01

    While the heaviest known elementary particle, the top quark, has been discovered in 1995 by the CDF and D0 collaborations in ttbar events, it took 14 more years until the observation of single top quark production. In this article, we discuss recent studies of single top quark production by the CDF and D0 collaborations at the Tevatron. In particular, we present the measurement of single top quark s- and t-channel production combined, the first observation of t-channel production, the simultaneous measurement of s- and t-channel production cross sections as well as the extraction of the CMK matrix element |Vtb}|.

  3. Handbook of single-molecule electronics

    Moth-Poulsen, Kasper

    2015-01-01

    Single-molecule electronics has evolved as a vibrant research field during the last two decades. The vision is to be able to create electronic components at the highest level of miniaturization-the single molecule. This book compiles and details cutting-edge research with contributions from chemists, physicists, theoreticians, and engineers. It covers all aspects of single-molecule electronics, from the theory through experimental realizations and the chemical synthesis of molecular components to the implementation of molecular components in future integrated circuits. This book describes in d

  4. CP Violation in Single Top Quark Production

    Geng, Weigang [Michigan State Univ., East Lansing, MI (United States)

    2012-01-01

    We present a search for CP violation in single top quark production with the DØ experiment at the Tevatron proton-antiproton collider. CP violation in the top electroweak interaction results in different single top quark production cross sections for top and antitop quarks. We perform the search in the single top quark final state using 5.4 fb-1 of data, in the s-channel, t-channel, and for both combined. At this time, we do not see an observable CP asymmetry.

  5. Single spin asymmetry for charm mesons

    Dominguez Zacarias, G. [PIMAyC, Eje Central Lazaro Cardenas No. 152, Apdo. Postal 14-805, D.F. (Mexico); Herrera, G.; Mercado, J. [Centro de Investigacion y de Estudios Avanzados, Apdo. Postal 14-740, D.F. (Mexico)

    2007-08-15

    We study single spin asymmetries of D{sup 0} and D{sup -} mesons in polarized proton-proton collisions. A two component model is used to describe charm meson production. The production of D mesons occurs by recombination of the constituents present in the initial state as well as by fragmentation of quarks in the final state. This model has proved to describe the production of charm. The recombination component involves a mechanism of spin alignment that ends up in a single spin asymmetry. Experimental measurements of single spin asymmetry for pions at RHIC are compared with the model. Predictions for the asymmetry in D mesons are presented. (orig.)

  6. Single spin asymmetry for charm mesons

    We study single spin asymmetries of D0 and D- mesons in polarized proton-proton collisions. A two component model is used to describe charm meson production. The production of D mesons occurs by recombination of the constituents present in the initial state as well as by fragmentation of quarks in the final state. This model has proved to describe the production of charm. The recombination component involves a mechanism of spin alignment that ends up in a single spin asymmetry. Experimental measurements of single spin asymmetry for pions at RHIC are compared with the model. Predictions for the asymmetry in D mesons are presented. (orig.)

  7. Photophysics of single silicon vacancy centers in diamond: implications for single photon emission

    Neu, Elke; Becher, Christoph

    2012-01-01

    Single silicon vacancy (SiV) color centers in diamond have recently shown the ability for high brightness, narrow bandwidth, room temperature single photon emission. This work develops a model describing the three level population dynamics of single SiV centers in diamond nanocrystals on iridium surfaces including an intensity dependent de-shelving process. Furthermore, we investigate the brightness and photostability of single centers and find maximum single photon rates of 6.2 Mcps under continuous excitation. We investigate the collection efficiency of the fluorescence and estimate quantum efficiencies of the SiV centers.

  8. Fiber-pigtailed optical tweezer for single-atom trapping and single-photon generation

    Garcia, Sébastien; Hohmann, Leander; Reichel, Jakob; Long, Romain

    2013-01-01

    We demonstrate a miniature, fiber-coupled optical tweezer to trap a single atom. The same fiber is used to trap a single atom and to read out its fluorescence. To obtain a low background level, the tweezer light is chopped, and we measure the influence of the chopping frequency on the atom's lifetime. We use the single atom as a single-photon source at 780 nm and measure the second-order correlation function of the emitted photons. Because of its miniature, robust, fiber-pigtailed design, this tweezer can be implemented in a broad range of experiments where single atoms are used as a resource.

  9. Single Family Loan Sale Initiative - National Offering

    Department of Housing and Urban Development — The FHA Office of Housing is conducting a series of mortgage loan sales under the Single Family Loan Sale (SFLS) Initiative. The current sales structure consists of...

  10. Single-phase induction motor design

    Viego, P.; Pyrhoenen, J.

    1995-07-01

    The increasing costs of electrical energy and the massive use of single-phase induction motors convey a significant importance to their design and optimisation. Millions of small induction motors are manufactured and installed annually in the world. In this book the general idea of the single-phase motor properties and machine design is presented. It is supposed that the reader is familiar with the main principles of the single-phase induction motor. The study concentrates on single-phase induction motor design and optimisation. Classification and characteristics of different types of motors and windings, calculation of magnetic system dimensions and windings, mathematical models, calculation of parameters and operational characteristics and finally optimisation techniques are included. Examples related to motor calculation and optimization are introduced. (orig.)

  11. Molecular junctions: Single-molecule contacts exposed

    Nichols, Richard J.; Higgins, Simon J.

    2015-05-01

    Using a scanning tunnelling microscopy-based method it is now possible to get an atomistic-level description of the most probable binding and contact configuration for single-molecule electrical junctions.

  12. Single Institution Feasibility Trials - Cancer Imaging Program

    Within the CIP program, the current R21 mechanism provides potential funding for small, single institution feasibility trials. The current announcement is titled In Vivo Cancer Imaging Exploratory/Developmental Grants.

  13. Barium Isotopes in Single Presolar Grains

    Pellin, M. J.; Davis, A. M.; Savina, M. R.; Kashiv, Y.; Clayton, R. N.; Lewis, R. S.; Amari, S.

    2001-01-01

    Barium isotopic compositions of single presolar grains were measured by laser ablation laser resonant ionization mass spectrometry and the implications of the data for stellar processes are discussed. Additional information is contained in the original extended abstract.

  14. Maldacena's consistency relation in single field inflation

    We investigate the consistency relation relating the squeezed limit of the bi-spectrum to the scalar spectral index in single field models of inflation. We give a simple integral formula for the bi-spectrum in the squeezed limit in terms of the free mode mode functions of the primordial curvature perturbation, in any Lorentz invariant single field model of inflation and without resorting to any approximation, generalizing a recent result obtained by Ganc and Komatsu in the case of canonical kinetic terms. We use our result to verify the consistency relation in an exactly solvable class of models with a non-trivial speed of sound. We then verify the consistency relation at the first non-trivial order in the slow-varying approximation in general single field inflation (a known result) and at second order in this approximation in canonical single field inflation. This document is composed of the slides of the presentation. (author)

  15. Improved Intermittency Analysis of Single Event Data

    Janik, R. A.; Ziaja, B.

    1998-01-01

    The intermittency analysis of single event data (particle moments) in multiparticle production is improved, taking into account corrections due to the reconstruction of history of a particle cascade. This approach is tested within the framework of the $\\alpha$-model.

  16. Superconducting nanowire single-photon imager

    Zhao, Qing-Yuan; Calandri, Niccolò; Dane, Andrew E; McCaughan, Adam N; Bellei, Francesco; Wang, Hao-Zhu; Santavicca, Daniel F; Berggren, Karl K

    2016-01-01

    Detecting spatial and temporal information of individual photons is a crucial technology in today's quantum information science. Among the existing single-photon detectors, superconducting nanowire single-photon detectors (SNSPDs) have been demonstrated with a sub-50 ps timing jitter, near unity detection efficiency1, wide response spectrum from visible to infrared and ~10 ns reset time. However, to gain spatial sensitivity, multiple SNSPDs have to be integrated into an array, whose spatial and temporal resolutions are limited by the multiplexing circuit. Here, we add spatial sensitivity to a single nanowire while preserving the temporal resolution from an SNSPD, thereby turning an SNSPD into a superconducting nanowire single-photon imager (SNSPI). To achieve an SNSPI, we modify a nanowire's electrical behavior from a lumped inductor to a transmission line, where the signal velocity is slowed down to 0.02c (where c is the speed of light). Consequently, we are able to simultaneously read out the landing locati...

  17. Single cell enzyme diagnosis on the chip

    Jensen, Sissel Juul; Harmsen, Charlotte; Nielsen, Mette Juul;

    2013-01-01

    Conventional diagnosis based on ensemble measurements often overlooks the variation among cells. Here, we present a droplet-microfluidics based platform to investigate single cell activities. Adopting a previously developed isothermal rolling circle amplification-based assay, we demonstrate detec...

  18. Single Incision Laparoscopic Splenectomy: Our First Experiences

    Umut Barbaros

    2011-06-01

    Full Text Available Objective: Most laparoscopic surgeons have attempted to reduce incisional morbidity and improve cosmetic outcomes by using less and smaller trocars. Single incision laparoscopic splenectomy is a new laparoscopic procedure. Herein we would like to present our experiences.Material and Methods: Between January 2009 and June 2009, data of the 7 patients who underwent single incision laparoscopic splenectomy were evaluated retrospectively.Results: There were 7 patients (5 females and 2 males with a mean age of 29.9 years. The most common splenectomy indication was idiopathic thrombocytopenic purpura. Single incision laparoscopic splenectomy was performed successfully in 6 patients. In one patient the operation was converted to an open procedure.Conclusion: With surgeons experienced in minimally invasive surgery, single incision laparoscopic splenectomy could be performed successfully. However, in order to demonstrate the differneces between standard laparoscopic splenectomy and SILS splenetomy, prospective randomized comparative studies are required.

  19. Single Photon Emission Computed Tomography (SPECT)

    ... Tools & Resources Stroke More Single Photon Emission Computed Tomography (SPECT) Updated:Sep 11,2015 What is a ... Heart Attack Myocardial Perfusion Imaging (MPI) Positron Emission Tomography (PET) Radionuclide Ventriculography, Radionuclide Angiography, MUGA Scan Heart ...

  20. A theoretical overview on single hard diffraction

    The concept of the Pomeron structure function and its application in Single Hard Diffraction at hadron colliders and in diffractive Deep Inelastic Scattering is critically reviewed. Some alternative approaches are briefly surveyed with a focus on QCD inspired models

  1. Hyperspectral Single Pixel Image Sensor Project

    National Aeronautics and Space Administration — This is a drastic enhancement to the current prototype which only allows us to collect visible light and reconstruct a single wavelength image. This approach is a...

  2. High Energy Single Frequency Resonant Amplifier Project

    National Aeronautics and Space Administration — This SBIR phase I project proposes a single frequency high energy resonant amplifier for remote sensing. Current state-of-art technologies can not provide all...

  3. Nanospintronics: when spintronics meets single electron physics

    As spintronics goes nano, new phenomena are predicted resulting from the interplay between spin dependent transport and single electron physics. The long term goal of manipulating spins one by one would open a promising path to quantum computing. Towards this end, there is an ever-growing effort to connect spin tanks (i.e. ferromagnetic leads) to smaller and smaller objects in order to study spintronics in reduced dimensions. As the dimensions are reduced, spin dependent transport is predicted to interplay with quantum and/or single electron charging effects. We review experiments and theories on the interplay between Coulomb blockade and spin properties (namely magneto-Coulomb effects) in structures where a single nano-object is connected to ferromagnetic leads. We then discuss briefly future directions in the emerging field of nanospintronics towards quantum dots, carbon nanotubes and single molecule magnets

  4. Single Working Moms Carry a Heart Burden

    ... Single Working Moms Carry a Heart Burden Stress, finances may boost cardiovascular risks for U.S. mothers, study ... the June 16 online edition of the American Journal of Public Health . SOURCES: Frank van Lenthe, Ph. ...

  5. Broadband single-molecule excitation spectroscopy

    Piatkowski, Lukasz; Gellings, Esther; van Hulst, Niek F.

    2016-01-01

    Over the past 25 years, single-molecule spectroscopy has developed into a widely used tool in multiple disciplines of science. The diversity of routinely recorded emission spectra does underpin the strength of the single-molecule approach in resolving the heterogeneity and dynamics, otherwise hidden in the ensemble. In early cryogenic studies single molecules were identified by their distinct excitation spectra, yet measuring excitation spectra at room temperature remains challenging. Here we present a broadband Fourier approach that allows rapid recording of excitation spectra of individual molecules under ambient conditions and that is robust against blinking and bleaching. Applying the method we show that the excitation spectra of individual molecules exhibit an extreme distribution of solvatochromic shifts and distinct spectral shapes. Importantly, we demonstrate that the sensitivity and speed of the broadband technique is comparable to that of emission spectroscopy putting both techniques side-by-side in single-molecule spectroscopy.

  6. Single DNA denaturation and bubble dynamics

    While the Watson-Crick double-strand is the thermodynamically stable state of DNA in a wide range of temperature and salt conditions, even at physiological conditions local denaturation bubbles may open up spontaneously due to thermal activation. By raising the ambient temperature, titration, or by external forces in single molecule setups bubbles proliferate until full denaturation of the DNA occurs. Based on the Poland-Scheraga model we investigate both the equilibrium transition of DNA denaturation and the dynamics of the denaturation bubbles with respect to recent single DNA chain experiments for situations below, at, and above the denaturation transition. We also propose a new single molecule setup based on DNA constructs with two bubble zones to measure the bubble coalescence and extract the physical parameters relevant to DNA breathing. Finally we consider the interplay between denaturation bubbles and selectively single-stranded DNA binding proteins.

  7. Defect free single crystal thin layer

    Elafandy, Rami Tarek Mahmoud

    2016-01-28

    A gallium nitride film can be a dislocation free single crystal, which can be prepared by irradiating a surface of a substrate and contacting the surface with an etching solution that can selectively etch at dislocations.

  8. Automated single-slide staining system

    Mills, S. M.; Wilkins, J. R.

    1974-01-01

    Apparatus developed to Gram-stain single slides automatically is flexible enough to accommodate other types of staining procedures. Method frees operator and eliminates necessity for subjective evaluations as to length of staining or decolorizing time.

  9. The influence of single parenthood on the social needs of the single parent

    Dionysia F. Antonopoulou

    2012-07-01

    Full Text Available The changes occurring in the socio-economic situation in our country shape the environment that single - parent families experience. The treatment of single- parent families as a factor of economic and social development is a key objective in a state with a social character. AIM: The aim of this study was to research the phenomenon of single- parent families in Greece, and the effect of single parenthood on the social needs of the single parent. MATERIAL-METHOD: A specially designed, anonymous questionnaire was used for this research, which was given to a random sample of single-parent families with dependent children both in the urban centers and in the province. The study sample consisted of 206 single parents with dependent children. The statistical analysis was carried out with the use of the statistical package SPSS, 16.00 (SPSS Inc, Chicago, IL. RESULTS: Of the 206 participants in the study, 181 were women and 25 were men. The average age of the heads of single parent families was 44 years, while 41.7% had one child and 41.3% had 2 children. Regarding the educational level of the participants, 39.3% were high school graduates. In relation to social needs, 66.1% of single parents expresed a need for psychological support. 27.2% reported the state for psychological support. 20.9% resorted to church and the 18.0% had applied to organizations. The 32.5% of single parents expressed a need for work. CONCLUSIONS: In Greek single-parent families there is an increased need for psychological support and employment. The psychological situation, as seen in the demand for psychological support of single parents with dependent children and the lack of employment, seem to relate to the form of single parenthood, marital status, educational level and residence of the single parent family.

  10. Analysis Of Single Phase Matrix Converter

    Divya Ahirrao; Bhagyashri Gaware

    2014-01-01

    This paper presents concept of single phase matrix converter. Single phase matrix converter (SPMC) performs a function such as frequency changer, rectifier, inverter; chopper. This reduces the need for new converter hardware. Pulse width modulation (SPWM) techniques are used to calculate the switch duty ratio to synthesis the output. The simulation of converter is carried out in MATLAB/SIMULINK. Hardware design is obtained using readily available IC‟s and other components. Thi...

  11. Position Control of Single Pneumatic Muscle Actuator

    FAN Wei; PENG Guang-zheng; NING Ru-xin

    2005-01-01

    The PID, fuzzy, self-organized fuzzy and self-organized fuzzy-PID controllers are adopted in the position control of single pneumatic muscle actuator. Experiments show that the self-organized fuzzy-PID is obviously effective for the position control of single pneumatic muscle actuator, which can realize precision within 0.3 mm and withstand 18N variable load plus about 36N fixed load. It is relatively precise and robust.

  12. Efficient synergistic single-cell genome assembly

    Narjes S. Movahedi

    2016-05-01

    Full Text Available As the vast majority of all microbes are unculturable, single-cell sequencing has become a significant method to gain insight into microbial physiology. Single-cell sequencing methods, currently powered by multiple displacement genome amplification (MDA, have passed important milestones such as finishing and closing the genome of a prokaryote. However, the quality and reliability of genome assemblies from single cells are still unsatisfactory due to uneven coverage depth and the absence of scattered chunks of the genome in the final collection of reads caused by MDA bias. In this work, our new algorithm Hybrid De novo Assembler (HyDA demonstrates the power of co-assembly of multiple single-cell genomic data sets through significant improvement of the assembly quality in terms of predicted functional elements and length statistics. Co-assemblies contain significantly more base pairs and protein coding genes, cover more subsystems, and consist of longer contigs compared to individual assemblies by the same algorithm as well as state-of-the-art single-cell assemblers SPAdes and IDBA-UD. Hybrid emph{De novo} Assembler (HyDA is also able to avoid chimeric assemblies by detecting and separating shared and exclusive pieces of sequence for input data sets. By replacing one deep single-cell sequencing experiment with a few single-cell sequencing experiments of lower depth, the co-assembly method can hedge against the risk of failure and loss of the sample, without significantly increasing sequencing cost. Application of the single-cell co-assembler HyDA to the study of three uncultured members of an alkane-degrading methanogenic community validated the usefulness of the co-assembly concept. HyDA is open source and publicly available at http://chitsazlab.org/software.html and the raw reads are available at http://chitsazlab.org/research.html.

  13. Fully overheated single-electron transistor.

    Laakso, M A; Heikkilä, T T; Nazarov, Yuli V

    2010-05-14

    We consider the fully overheated single-electron transistor, where the heat balance is determined entirely by electron transfers. We find three distinct transport regimes corresponding to cotunneling, single-electron tunneling, and a competition between the two. We find an anomalous sensitivity to temperature fluctuations at the crossover between the two latter regimes that manifests in an exceptionally large Fano factor of current noise. PMID:20866990

  14. On Single-scanline Camera Calibration

    Horaud, Radu; Mohr, Roger; Lorecki, Boguslaw

    1993-01-01

    A method for calibrating single scanline CCD cameras is described. It is shown that the more classical 2D camera calibration techniques are necessary but not sufficient for solving the 1D camera calibration problem. A model for single scanline cameras is proposed, and a two-step procedure for estimating its parameters is provided. It is also shown how the extrinsic camera parameters can be determined geometrically without making explicit the intrinsic camera parameters. The accuracy of the ca...

  15. Efficient Synergistic Single-Cell Genome Assembly.

    Movahedi, Narjes S; Embree, Mallory; Nagarajan, Harish; Zengler, Karsten; Chitsaz, Hamidreza

    2016-01-01

    As the vast majority of all microbes are unculturable, single-cell sequencing has become a significant method to gain insight into microbial physiology. Single-cell sequencing methods, currently powered by multiple displacement genome amplification (MDA), have passed important milestones such as finishing and closing the genome of a prokaryote. However, the quality and reliability of genome assemblies from single cells are still unsatisfactory due to uneven coverage depth and the absence of scattered chunks of the genome in the final collection of reads caused by MDA bias. In this work, our new algorithm Hybrid De novo Assembler (HyDA) demonstrates the power of coassembly of multiple single-cell genomic data sets through significant improvement of the assembly quality in terms of predicted functional elements and length statistics. Coassemblies contain significantly more base pairs and protein coding genes, cover more subsystems, and consist of longer contigs compared to individual assemblies by the same algorithm as well as state-of-the-art single-cell assemblers SPAdes and IDBA-UD. Hybrid De novo Assembler (HyDA) is also able to avoid chimeric assemblies by detecting and separating shared and exclusive pieces of sequence for input data sets. By replacing one deep single-cell sequencing experiment with a few single-cell sequencing experiments of lower depth, the coassembly method can hedge against the risk of failure and loss of the sample, without significantly increasing sequencing cost. Application of the single-cell coassembler HyDA to the study of three uncultured members of an alkane-degrading methanogenic community validated the usefulness of the coassembly concept. HyDA is open source and publicly available at http://chitsazlab.org/software.html, and the raw reads are available at http://chitsazlab.org/research.html. PMID:27243002

  16. Early Loaded Single Implant Reinforced Mandibular Overdenture

    Nischal, K; Chowdhary, R.

    2016-01-01

    Rehabilitating atrophied mandible with two-implant supported denture is a common treatment modality for implant retained removable overdenture in mandible. This paper aims to design a treatment modality where single implant reinforced overdenture is fabricated for a severely atrophied mandibular ridge with early loading protocol. Results of studies have shown that a single implant mandibular overdenture significantly increases the satisfaction and quality of life of patients with edentulism. ...

  17. Molecular pathology of single gene disorders.

    Weatherall, D. J.

    1987-01-01

    Recent studies using recombinant DNA technology have led to an understanding of the basic molecular pathology of single gene disorders. Furthermore, methods are being developed for finding genes for conditions, whose underlying biochemistry is still not understood, or which may contribute to polygenic systems that underlie common diseases. As well as providing new approaches to carrier detection, prenatal diagnosis, and treatment of single gene disorders, these advances promise to provide imp...

  18. Neutron forward diffraction by single crystal prisms

    Sohrab Abbas; Apoorva G Wagh; Markus Strobl; Wolfgang Treimer

    2008-11-01

    We have derived analytic expressions for the deflection as well as transmitted fraction of monochromatic neutrons forward diffracted by a single crystal prism. In the vicinity of a Bragg reflection, the neutron deflection deviates sharply from that for an amorphous prism, exhibiting three orders of magnitude greater sensitivity to the incidence angle. We have measured the variation of neutron deflection and transmission across a Bragg reflection, for several single crystal prisms. The results agree well with theory.

  19. Single access retroperitoneoscopic adrenalectomy: initial experience

    Beiša, Virgilijus; Kildušis, Edvinas; Strupas, Kęstutis

    2011-01-01

    Today, endoscopic adrenalectomy has become a gold standard in endocrine surgery. To minimize the morbidity and improve cosmesis, single access retroperitoneoscopic adrenalectomy (SARA) has been developed as an alternative to traditional multiport laparoscopy and single port access (SPA) surgery, potentially exploiting even more the already proven benefits of minimally invasive surgery. We applied the SARA technique to adrenalectomy using the posterior retroperitoneal approach. The aim is to h...

  20. Single atrium - a rare case report

    Jyoti Prasad Kalita; Manuj Kumar Saikia; Amitav Sharma; Biswajeet Saikia; Gautam Chandra Das

    2016-01-01

    Single atrium is a rare congenital heart disease in which there is developmental absence of both septum primum and secondum part of atrial septum. Present study reports a case of an adolescent female patient with single atrium without any endocardial cushion defect and other variety of congenital heart disease. Clinically the patient presented with features of congestive heart failure. She underwent successful surgical separation of atrium. [Int J Res Med Sci 2016; 4(7.000): 3074-3076

  1. Supra-Pubic Single Incision Cholecystectomy

    Hagen, Monika E.; Wagner, Oliver J.; Thompson, Kari; Jacobsen, Garth; Spivack, Adam; Wong, Brian; Talamini, Mark; Horgan, Santiago

    2009-01-01

    Introduction Surgery is moving towards less invasive and cosmetically superior approaches such as single incision laparoscopy (SIL). While trans-umbilical SIL is gaining popularity, incisions may lead to post-operative deformations of the umbilicus and the possibility of an increased rate of incisional hernias. Access within the pubic hairline allows preservation of the umbilicus and results in a scar which is concealed within the pubic hair. Methods Supra-pubic single incision cholecystectom...

  2. Single sheet metal oxides and hydroxides

    Huang, Lizhi

    The synthesis of layered double hydroxides (LDHs) provides a relatively easy and traditional way to build versatile chemical compounds with a rough control of the bulk structure. The delamination of LDHs to form their single host layers (2D nanosheets) and the capability to reassemble them offer ......) Delamination of the LDHs structure (oxGRC12) with the formation of single sheet iron (hydr)oxide (SSI). (3) Assembly of the new 2D nanosheets layer by layer to achieve desired functionalities....

  3. SET Backaction on the Single Electron Box

    Turek, B. A.; Lehnert, K. W.; Clerk, A.; Gunnarsson, D.; Bladh, K.; Delsing, P.; Schoelkopf, R. J.

    2005-01-01

    We report an experimental observation of the backaction of a Single Electron Transistor (SET) measuring the Coulomb staircase of a single electron box. As current flows through the SET, the charge state of the SET island fluctuates. These fluctuations capacitively couple to the box and cause changes in the position, width, and asymmetry of the Coulomb staircase. A sequential tunnelling model accurately recreates these effects, confirming this mechanism of the backaction of an SET. This is a f...

  4. Single particle dynamics in circular accelerators

    Ruth, R.D.

    1986-10-01

    The purpose of this paper is to introduce the reader to the theory associated with the transverse dynamics of single particle, in circular accelerators. The discussion begins with a review of Hamiltonian dynamics and canonical transformations. The case of a single particle in a circular accelerator is considered with a discussion of non-linear terms and chromaticity. The canonical perturbation theory is presented and nonlinear resonances are considered. Finally, the concept of renormalization and residue criterion are examined. (FI)

  5. On-Chip Single Plasmon Detection

    Heeres, Reinier W.; Dorenbos, Sander N.; Koene, Benny; Solomon, Glenn S.; Kouwenhoven, Leo P.; Zwiller, Valery

    2010-01-01

    Surface plasmon polaritons (plasmons) have the potential to interface electronic and optical devices. They could prove extremely useful for integrated quantum information processing. Here we demonstrate on-chip electrical detection of single plasmons propagating along gold waveguides. The plasmons are excited using the single-photon emission of an optically emitting quantum dot. After propagating for several micrometers, the plasmons are coupled to a superconducting detector in the near-field...

  6. Single-molecule recognition imaging microscopy

    Stroh, C.; Wang, H.; Bash, R.; B Ashcroft; Nelson, J.; Gruber, H; Lohr, D.; Lindsay, S M; Hinterdorfer, P.

    2004-01-01

    Atomic force microscopy is a powerful and widely used imaging technique that can visualize single molecules and follow processes at the single-molecule level both in air and in solution. For maximum usefulness in biological applications, atomic force microscopy needs to be able to identify specific types of molecules in an image, much as fluorescent tags do for optical microscopy. The results presented here demonstrate that the highly specific antibody–antigen interaction can be used to gener...

  7. Single cell genomics: advances and future perspectives.

    Macaulay, Iain C.; Thierry Voet

    2014-01-01

    Advances in whole-genome and whole-transcriptome amplification have permitted the sequencing of the minute amounts of DNA and RNA present in a single cell, offering a window into the extent and nature of genomic and transcriptomic heterogeneity which occurs in both normal development and disease. Single-cell approaches stand poised to revolutionise our capacity to understand the scale of genomic, epigenomic, and transcriptomic diversity that occurs during the lifetime of an individual organis...

  8. Experimental measurements on a single sweeping jet

    Hirsch, Damian; Graff, Emilio; Gharib, Morteza

    2014-11-01

    ``Sweeping jets'' proved their effectiveness as Active Flow Control (AFC) actuators in improving the performance of vertical tails of generic and full-scale models. To gain further knowledge about the fundamental flow physics, the jets were investigated experimentally. The influence of a single jet on its surroundings was studied, especially the entrainment region. The results were compared to previous experiments to study the difference between a single isolated jet and multiple jets mounted on a vertical tail. Supported by the Boeing Company.

  9. Single-molecule dynamics at variable temperatures

    Zondervan, Rob

    2006-01-01

    Single-molecule optics has evolved from a specialized variety of optical spectroscopy at low temperatures into a versatile tool to address questions in physics, chemistry, biology, and materials science. In this thesis, the potential of single-molecule (and ensemble) optical microscopy at variable temperatures is demonstrated: Electron transfer has been identified as a crucial step in the photodynamics of organic fluorophores, and long-term memory effects have been discovered in the relaxatio...

  10. Efficient Synergistic Single-Cell Genome Assembly

    Movahedi, Narjes S.; Embree, Mallory; Nagarajan, Harish; Zengler, Karsten; Chitsaz, Hamidreza

    2016-01-01

    As the vast majority of all microbes are unculturable, single-cell sequencing has become a significant method to gain insight into microbial physiology. Single-cell sequencing methods, currently powered by multiple displacement genome amplification (MDA), have passed important milestones such as finishing and closing the genome of a prokaryote. However, the quality and reliability of genome assemblies from single cells are still unsatisfactory due to uneven coverage depth and the absence of scattered chunks of the genome in the final collection of reads caused by MDA bias. In this work, our new algorithm Hybrid De novo Assembler (HyDA) demonstrates the power of coassembly of multiple single-cell genomic data sets through significant improvement of the assembly quality in terms of predicted functional elements and length statistics. Coassemblies contain significantly more base pairs and protein coding genes, cover more subsystems, and consist of longer contigs compared to individual assemblies by the same algorithm as well as state-of-the-art single-cell assemblers SPAdes and IDBA-UD. Hybrid De novo Assembler (HyDA) is also able to avoid chimeric assemblies by detecting and separating shared and exclusive pieces of sequence for input data sets. By replacing one deep single-cell sequencing experiment with a few single-cell sequencing experiments of lower depth, the coassembly method can hedge against the risk of failure and loss of the sample, without significantly increasing sequencing cost. Application of the single-cell coassembler HyDA to the study of three uncultured members of an alkane-degrading methanogenic community validated the usefulness of the coassembly concept. HyDA is open source and publicly available at http://chitsazlab.org/software.html, and the raw reads are available at http://chitsazlab.org/research.html.

  11. Indium Single-Ion Frequency Standard

    Nagourney, Warren

    2001-01-01

    A single laser-cooled indium ion is a promising candidate for an ultimate resolution optical time or frequency standard. It can be shown that single ions from group IIIA of the periodic table (indium, thallium, etc.) can have extremely small systematic errors. In addition to being free from Doppler, transit-time and collisional shifts, these ions are also quite insensitive to perturbations from ambient magnetic and electric fields (mainly due to the use of a J=0-0 transition for spectroscopy). Of all group IIIA ions, indium seems to be the most practical, since it is heavy enough to have a tolerable intercombination cooling transition rate and (unlike thallium) has transitions which are easily accessible with frequency multiplied continuous-wave lasers. A single indium ion standard has a potential inaccuracy of one part in 10(exp 18) for integration times of 10(exp 6) seconds. We have made substantial progress during the grant period in constructing a frequency standard based upon a single indium ion. At the beginning of the grant period, single indium ions were being successfully trapped, but the lasers and optical systems were inadequate to achieve the desired goal. We have considerably improved the stability of the dye laser used to cool the ions and locked it to a molecular resonance line, making it possible to observe stable cooling-line fluorescence from a single indium ion for reasonable periods of time, as required by the demands of precision spectroscopy. We have substantially improved the single-ion fluorescence signal with significant benefits for the detection efficiency of forbidden transitions using the 'shelving' technique. Finally, we have constructed a compact, efficient UV 'clock' laser and observed 'clock' transitions in single indium ions using this laser system. We will elaborate on these accomplishments.

  12. Testing the single-state dominance hypothesis

    Álvarez-Rodríguez, R. [Universidad Politécnica de Madrid, Avda. Juan Herrera 4, E-28040 Madrid (Spain); Moreno, O.; Moya de Guerra, E. [Universidad Complutense de Madrid, Avda. Complutense, E-28040 Madrid (Spain); Sarriguren, P. [Instituto de Estructura de la Materia (CSIC), Serrano 123, E-28006 Madrid (Spain); Šimkovic, F. [Comenius University, SK-842 15 Bratislava (Slovakia); Faessler, A. [University of Tübingen, D-72076 Tübingen (Germany)

    2013-12-30

    We present a theoretical analysis of the single-state dominance hypothesis for the two-neutrino double-beta decay process. The theoretical framework is a proton-neutron QRPA based on a deformed Hartree-Fock mean field with BCS pairing correlations. We focus on the decays of {sup 100}Mo, {sup 116}Cd and {sup 128}Te. We do not find clear evidences for single-state dominance within the present approach.

  13. Electrically Anisotropic Layered Perovskite Single Crystal

    Li, Ting-You

    2016-04-01

    Organic-inorganic hybrid perovskites (OIHPs), which are promising materials for electronic and optoelectronic applications (1-10), have made into layered organic-inorganic hybrid perovskites (LOIHPs). These LOIHPs have been applied to thin-film transistors, solar cells and tunable wavelength phosphors (11-18). It is known that devices fabricated with single crystal exhibit the superior performance, which makes the growth of large-sized single crystals critical for future device applications (19-23). However, the difficulty in growing large-sized LOIHPs single crystal with superior electrical properties limits their practical applications. Here, we report a method to grow the centimeter-scaled LOIHP single crystal of [(HOC2H4NH3)2PbI4], demonstrating the potentials in mass production. After that, we reveal anisotropic electrical and optoelectronic properties which proved the carrier propagating along inorganic framework. The carrier mobility of in-inorganic-plane (in-plane) devices shows the average value of 45 cm2 V–1 s–1 which is about 100 times greater than the record of LOIHP devices (15), showing the importance of single crystal in device application. Moreover, the LOIHP single crystals show its ultra-short carrier lifetime of 42.7 ps and photoluminescence quantum efficiency (PLQE) of 25.4 %. We expect this report to be a start of LOIHPs for advanced applications in which the anisotropic properties are needed (24-25), and meets the demand of high-speed applications and fast-response applications.

  14. Treatment of Plasmodium chabaudi Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System

    Zoraima Neto; Marta Machado; Ana Lindeza; Virgílio do Rosário; Gazarini, Marcos L.; Dinora Lopes

    2013-01-01

    Antimalarial drug resistance remains a major obstacle in malaria control. Evidence from Southeast Asia shows that resistance to artemisinin combination therapy (ACT) is inevitable. Ethnopharmacological studies have confirmed the efficacy of curcumin against Plasmodium spp. Drug interaction assays between curcumin/piperine/chloroquine and curcumin/piperine/artemisinin combinations and the potential of drug treatment to interfere with the ubiquitin proteasome system (UPS) were analyzed. In vivo...

  15. Identifying single copy orthologs in Metazoa.

    Christopher J Creevey

    2011-12-01

    Full Text Available The identification of single copy (1-to-1 orthologs in any group of organisms is important for functional classification and phylogenetic studies. The Metazoa are no exception, but only recently has there been a wide-enough distribution of taxa with sufficiently high quality sequenced genomes to gain confidence in the wide-spread single copy status of a gene.Here, we present a phylogenetic approach for identifying overlooked single copy orthologs from multigene families and apply it to the Metazoa. Using 18 sequenced metazoan genomes of high quality we identified a robust set of 1,126 orthologous groups that have been retained in single copy since the last common ancestor of Metazoa. We found that the use of the phylogenetic procedure increased the number of single copy orthologs found by over a third more than standard taxon-count approaches. The orthologs represented a wide range of functional categories, expression profiles and levels of divergence.To demonstrate the value of our set of single copy orthologs, we used them to assess the completeness of 24 currently published metazoan genomes and 62 EST datasets. We found that the annotated genes in published genomes vary in coverage from 79% (Ciona intestinalis to 99.8% (human with an average of 92%, suggesting a value for the underlying error rate in genome annotation, and a strategy for identifying single copy orthologs in larger datasets. In contrast, the vast majority of EST datasets with no corresponding genome sequence available are largely under-sampled and probably do not accurately represent the actual genomic complement of the organisms from which they are derived.

  16. Comparing the linewidths from single-pass SPDC and singly resonant cavity SPDC

    Slattery, Oliver; Ma, Lijun; Kuo, Paulina; Tang, Xiao

    2015-09-01

    Spontaneous parametric down-conversion (SPDC) is a common method to generate entangled photon pairs for use in quantum communications. The generated single photon linewidth is a critical issue for photon-atom interactions in quantum memory applications. We compare the linewidths of greatly non-degenerate single photon pairs from SPDC generated in the single-pass case and the singly-resonant cavity case. For a 6 mm periodically poled lithium niobate (PPLN) crystal, the linewidth of the generated signal photons is reduced from 1 THz in the single pass case to tens of MHz in the singly-resonant cavity case, while the brightness within the modal lineiwdth is increased by a factor of the cavity finesse, though the overall SPDC generation rate remains unchanged.

  17. Dissipation-enabled efficient excitation transfer from a single photon to a single quantum emitter

    Trautmann, N.; Alber, G.

    2016-05-01

    We propose a scheme for triggering a dissipation-dominated highly efficient excitation transfer from a single-photon wave packet to a single quantum emitter. This single-photon-induced optical pumping turns dominant dissipative processes, such as spontaneous photon emission by the emitter or cavity decay, into valuable tools for quantum information processing and quantum communication. It works for an arbitrarily shaped single-photon wave packet with sufficiently small bandwidth provided a matching condition is satisfied which balances the dissipative rates involved. Our scheme does not require additional laser pulses or quantum feedback and does not rely on high finesse optical resonators. In particular, it can be used to enhance significantly the coupling of a single photon to a single quantum emitter implanted in a one-dimensional waveguide or even in a free space scenario. We demonstrate the usefulness of our scheme for building a deterministic quantum memory and a deterministic frequency converter between photonic qubits of different wavelengths.

  18. Investigation on single carbon atom transporting through the single-walled carbon nanotube by MD simulation

    The single carbon atom transporting through the single-walled carbon nanotube has been studied by molecular-dynamics (MD) simulation. We got different trajectories of the carbon atom by changing the input parameters. The simulation results indicate that the single carbon atom with low energy can transport through the carbon nanotube under some input conditions and result in different trajectories being straight line or 'rosette' or circular. (authors)

  19. Autopsy Findings in Conjoined Twin with Single Heart and Single Liver

    Kar Asaranti; Mohanty Pranati; Kar Tushar; Behera Jagadish; Behera Susmita; Nayak Amarendra

    2012-01-01

    Thoracoomphalopagus is the commonest type of conjoined twin where the bodies are fused from upper chest to lower chest. The autopsy done can help counsil the parents for further pregnancies and determine the prognosis depending upon the type of cardiac anomaly by Seo classification when detected antenatally. We describe the detail pathological autopsy of such a case with single heart and single liver. A detail autopsy was done on the twin fetus. The twins shared a single heart and sometimes t...

  20. Bright Single Photon Emitter in Silicon Carbide

    Lienhard, Benjamin; Schroeder, Tim; Mouradian, Sara; Dolde, Florian; Trong Tran, Toan; Aharonovich, Igor; Englund, Dirk

    Efficient, on-demand, and robust single photon emitters are of central importance to many areas of quantum information processing. Over the past 10 years, color centers in solids have emerged as excellent single photon emitters. Color centers in diamond are among the most intensively studied single photon emitters, but recently silicon carbide (SiC) has also been demonstrated to be an excellent host material. In contrast to diamond, SiC is a technologically important material that is widely used in optoelectronics, high power electronics, and microelectromechanical systems. It is commercially available in sizes up to 6 inches and processes for device engineering are well developed. We report on a visible-spectrum single photon emitter in 4H-SiC. The emitter is photostable at both room and low temperatures, and it enables 2 million photons/second from unpatterned bulk SiC. We observe two classes of orthogonally polarized emitters, each of which has parallel absorption and emission dipole orientations. Low temperature measurements reveal a narrow zero phonon line with linewidth < 0.1 nm that accounts for more than 30% of the total photoluminescence spectrum. To our knowledge, this SiC color emitter is the brightest stable room-temperature single photon emitter ever observed.

  1. Diamond-based single-photon emitters

    The exploitation of emerging quantum technologies requires efficient fabrication of key building blocks. Sources of single photons are extremely important across many applications as they can serve as vectors for quantum information-thereby allowing long-range (perhaps even global-scale) quantum states to be made and manipulated for tasks such as quantum communication or distributed quantum computation. At the single-emitter level, quantum sources also afford new possibilities in terms of nanoscopy and bio-marking. Color centers in diamond are prominent candidates to generate and manipulate quantum states of light, as they are a photostable solid-state source of single photons at room temperature. In this review, we discuss the state of the art of diamond-based single-photon emitters and highlight their fabrication methodologies. We present the experimental techniques used to characterize the quantum emitters and discuss their photophysical properties. We outline a number of applications including quantum key distribution, bio-marking and sub-diffraction imaging, where diamond-based single emitters are playing a crucial role. We conclude with a discussion of the main challenges and perspectives for employing diamond emitters in quantum information processing.

  2. Oriented single crystalline titanium dioxide nanowires

    We report the synthesis of oriented single crystalline titanium dioxide (TiO2) nanowire arrays on titanium foil. The synthesis method relies on the ability to grow single crystal sodium titanate (Na2Ti2O5·H2O) nanowires on titanium foil through a novel alkali hydrothermal growth process. Following growth, the Na2Ti2O5·H2O nanowires are converted to protonated bititanate (H2Ti2O5·H2O) nanowires through an ion-exchange reaction without changing their morphology or crystal structure. Finally, the protonated bititanate nanowires are converted to single crystalline anatase TiO2 nanowires through a topotactic transformation by calcination. These three sequential steps yield a carpet of 2-50 μm long single crystalline nanowires oriented in the [100] direction and primarily normal to the titanium foil. Even longer nanowires can be grown. The single crystal TiO2 nanowire arrays on flexible titanium substrate may be used in photocatalytic and photovoltaic devices such as dye-sensitized solar cells and may enhance their performance by providing fast electron transport. The nanowires can also be used as templates for producing hierarchical nanostructures such as nanowires decorated with nanoparticles on their periphery or nanotubes with walls made of nanoparticles.

  3. Technologies for Single-Cell Isolation

    Andre Gross

    2015-07-01

    Full Text Available The handling of single cells is of great importance in applications such as cell line development or single-cell analysis, e.g., for cancer research or for emerging diagnostic methods. This review provides an overview of technologies that are currently used or in development to isolate single cells for subsequent single-cell analysis. Data from a dedicated online market survey conducted to identify the most relevant technologies, presented here for the first time, shows that FACS (fluorescence activated cell sorting respectively Flow cytometry (33% usage, laser microdissection (17%, manual cell picking (17%, random seeding/dilution (15%, and microfluidics/lab-on-a-chip devices (12% are currently the most frequently used technologies. These most prominent technologies are described in detail and key performance factors are discussed. The survey data indicates a further increasing interest in single-cell isolation tools for the coming years. Additionally, a worldwide patent search was performed to screen for emerging technologies that might become relevant in the future. In total 179 patents were found, out of which 25 were evaluated by screening the title and abstract to be relevant to the field.

  4. Single-shot and single-sensor high/super-resolution microwave imaging based on metasurface

    Libo Wang; Lianlin Li; Yunbo Li; Hao Chi Zhang; Tie Jun Cui

    2016-01-01

    Real-time high-resolution (including super-resolution) imaging with low-cost hardware is a long sought-after goal in various imaging applications. Here, we propose broadband single-shot and single-sensor high-/super-resolution imaging by using a spatio-temporal dispersive metasurface and an imaging reconstruction algorithm. The metasurface with spatio-temporal dispersive property ensures the feasibility of the single-shot and single-sensor imager for super- and high-resolution imaging, since ...

  5. An automatic single channel analyzer based on single-chip microcomputer

    The hardware and software of an automatic single channel analyzer based on AT89C51RC single-chip microcomputer is described in this paper. The equipment takes a method of channel-width-adjusting symmetrically, and makes use of single-chip microcomputer to control the two DAC0832 so as to adjust the discriminating threshold and channel-width automatically. As a result, the auto-measuring of the single channel analyzer is realized. Its circuit configuration is simple, and the uniformity of its channel-width is well, too. (authors)

  6. Single ion implantation for single donor devices using Geiger mode detectors

    Bielejec, E.; Seamons, J. A.; Carroll, M. S.

    2010-02-01

    Electronic devices that are designed to use the properties of single atoms such as donors or defects have become a reality with recent demonstrations of donor spectroscopy, single photon emission sources, and magnetic imaging using defect centers in diamond. Ion implantation, an industry standard for atom placement in materials, requires augmentation for single ion capability including a method for detecting a single ion arrival. Integrating single ion detection techniques with the single donor device construction region allows single ion arrival to be assured. Improving detector sensitivity is linked to improving control over the straggle of the ion as well as providing more flexibility in lay-out integration with the active region of the single donor device construction zone by allowing ion sensing at potentially greater distances. Using a remotely located passively gated single ion Geiger mode avalanche diode (SIGMA) detector we have demonstrated 100% detection efficiency at a distance of >75 µm from the center of the collecting junction. This detection efficiency is achieved with sensitivity to ~600 or fewer electron-hole pairs produced by the implanted ion. Ion detectors with this sensitivity and integrated with a thin dielectric, for example a 5 nm gate oxide, using low energy Sb implantation would have an end of range straggle of 98% for counting one and only one ion for a false count probability of 10-4 at an average ion number per gated window of 0.015.

  7. Photon Statistics of Single-Photon Quantum States in Real Single Photon Detection

    李刚; 李园; 王军民; 彭堃墀; 张天才

    2004-01-01

    @@ Single photon detection (SPD) with high quantum efficiency has been widely used for measurement of different quantum states with different photon distributions.Based on the direct single SPD and double-SPD of HBT configuration, we discuss the effect of a real SPD on the photon statistics measurement and it shows that the measured photon distributions for different quantum states are corrected in different forms.The results are confirmed by experiment with the strongly attenuated coherent light and thermal light.This system can be used to characterize the photon statistics of the fluorescence light from single atom or single molecular.

  8. Handbook of Single-Molecule Biophysics

    Hinterdorfer, Peter

    2009-01-01

    The last decade has seen the development of a number of novel biophysical methods that allow the manipulation and study of individual biomolecules. The ability to monitor biological processes at this fundamental level of sensitivity has given rise to an improved understanding of the underlying molecular mechanisms. Through the removal of ensemble averaging, distributions and fluctuations of molecular properties can be characterized, transient intermediates identified, and catalytic mechanisms elucidated. By applying forces on biomolecules while monitoring their activity, important information can be obtained on how proteins couple function to structure. The Handbook of Single-Molecule Biophysics provides an introduction to these techniques and presents an extensive discussion of the new biological insights obtained from them. Coverage includes: Experimental techniques to monitor and manipulate individual biomolecules The use of single-molecule techniques in super-resolution and functional imaging Single-molec...

  9. Fourier microscopy of single plasmonic scatterers

    Sersic, Ivana; Koenderink, A Femius

    2011-01-01

    We report a new experimental technique for quantifying the angular distribution of light scattered by single plasmonic and metamaterial nanoscatterers, based on Fourier microscopy in a dark field confocal set up. This new set up is a necessary tool for quantifying the scattering properties of single plasmonic and meatamaterial building blocks, as well as small coupled clusters of such building blocks, which are expected to be the main ingredients of nano-antennas, light harvesting structures and transformation optics. We present a set of measurements on Au nanowires of different lengths and show how the radiation pattern of single Au nanowires evolve with wire length and as a function of driving polarization and wave vector.

  10. Acoustic effects of single electrostatic discharges

    Orzech, Łukasz

    2015-10-01

    Electric discharges, depending on their character, can emit different types of energy, resulting in different effects. Single electrostatic discharges besides generation of electromagnetic pulses are also the source of N acoustic waves. Their specified parameters depending on amount of discharging charge enable determination of value of released charge in a function of acoustic descriptor (e.g. acoustic pressure). Presented approach is the basics of acoustic method for measurement of single electrostatic discharges, enabling direct and contactless measurement of value of charge released during ESD. Method for measurement of acoustic effect of impact of a single electrostatic discharge on the environment in a form of pressure shock wave and examples of acoustic descriptors in a form of equation Q=f(pa) are described. The properties of measuring system as well as the results of regression static analyses used to determine the described relationships are analysed in details.

  11. Titania single crystals with a curved surface

    Yang, Shuang; Yang, Bing Xing; Wu, Long; Li, Yu Hang; Liu, Porun; Zhao, Huijun; Yu, Yan Yan; Gong, Xue Qing; Yang, Hua Gui

    2014-11-01

    Owing to its scientific and technological importance, crystallization as a ubiquitous phenomenon has been widely studied over centuries. Well-developed single crystals are generally enclosed by regular flat facets spontaneously to form polyhedral morphologies because of the well-known self-confinement principle for crystal growth. However, in nature, complex single crystalline calcitic skeleton of biological organisms generally has a curved external surface formed by specific interactions between organic moieties and biocompatible minerals. Here we show a new class of crystal surface of TiO2, which is enclosed by quasi continuous high-index microfacets and thus has a unique truncated biconic morphology. Such single crystals may open a new direction for crystal growth study since, in principle, crystal growth rates of all facets between two normal {101} and {011} crystal surfaces are almost identical. In other words, the facet with continuous Miller index can exist because of the continuous curvature on the crystal surface.

  12. Early Loaded Single Implant Reinforced Mandibular Overdenture.

    Nischal, K; Chowdhary, R

    2016-01-01

    Rehabilitating atrophied mandible with two-implant supported denture is a common treatment modality for implant retained removable overdenture in mandible. This paper aims to design a treatment modality where single implant reinforced overdenture is fabricated for a severely atrophied mandibular ridge with early loading protocol. Results of studies have shown that a single implant mandibular overdenture significantly increases the satisfaction and quality of life of patients with edentulism. Midline fracture of the prosthesis is the most common complication related to single implant and two-implant retained mandibular overdentures. To manage such complication, a thin metal mesh is used to reinforce the overdenture and also to make the prostheses lighter and cost effective as compared to conventional cast metal framework. PMID:27403350

  13. Early Loaded Single Implant Reinforced Mandibular Overdenture

    K. Nischal

    2016-01-01

    Full Text Available Rehabilitating atrophied mandible with two-implant supported denture is a common treatment modality for implant retained removable overdenture in mandible. This paper aims to design a treatment modality where single implant reinforced overdenture is fabricated for a severely atrophied mandibular ridge with early loading protocol. Results of studies have shown that a single implant mandibular overdenture significantly increases the satisfaction and quality of life of patients with edentulism. Midline fracture of the prosthesis is the most common complication related to single implant and two-implant retained mandibular overdentures. To manage such complication, a thin metal mesh is used to reinforce the overdenture and also to make the prostheses lighter and cost effective as compared to conventional cast metal framework.

  14. A single-electron counter for nanodosimetry

    Breskin, A.; Chechik, R.; Pansky, A.; Shchemelinin, S. [Weizmann Inst. of Science, Rehovot (Israel). Dept. of Particle Physics; Colautti, P.; Conte, V.; De Nardo, L.; Talpo, G. [Istituto Nazionale di Fisica Nucleare, Legnaro (Italy); Tornielli, G. [Istituto Nazionale di Fisica Nucleare, Padua (Italy)

    1995-12-31

    A detector has been devised able to measure with high resolution the primary ionisation yield in tissue-equivalent gas volumes of a few nanometers equivalent length. The sensitive ionisation volume is a wall-less millimetric region defined by a properly shaped electric field. Free electrons created by the radiation inside the sensitive volume are collected into an electron multiplier, capable of efficiently counting single electrons at low gas pressure. The single-electron detection system consists of a long drift column attached to a multistep proportional counter. The electron cloud created by the radiation inside the sensitive volume, diffuses along the drift column. Single electrons, successively arriving at the multiplier are amplified, giving rise to a pulse trail from which the original number of ionisation electrons is counted. The experimental set-up, the electron counting principle, and first data are presented and discussed. (author).

  15. A single-electron counter for nanodosimetry

    A detector has been devised able to measure with high resolution the primary ionisation yield in tissue-equivalent gas volumes of a few nanometers equivalent length. The sensitive ionisation volume is a wall-less millimetric region defined by a properly shaped electric field. Free electrons created by the radiation inside the sensitive volume are collected into an electron multiplier, capable of efficiently counting single electrons at low gas pressure. The single-electron detection system consists of a long drift column attached to a multistep proportional counter. The electron cloud created by the radiation inside the sensitive volume, diffuses along the drift column. Single electrons, successively arriving at the multiplier are amplified, giving rise to a pulse trail from which the original number of ionisation electrons is counted. The experimental set-up, the electron counting principle, and first data are presented and discussed. (author)

  16. Watching single protein molecules in action

    Heiðarsson, Pétur Orri

    . This knowledge-gap is partly due to our inability to unveil the details of folding mechanisms that can be buried in the ensemble-averaged output of traditional bulk methods. Single-molecule techniques have provided a perspective beyond the ensemble average and enable studying the folding trajectories...... of protein molecules in unprecedented detail. These methods can, in principle, detect rare folding or misfolding events, and ultimately lead to a reconstruction of the free energy landscape. In this thesis, the folding mechanism of both single- and double-domain proteins is unraveled using single......-molecule optical tweezers. We first focused on the mechanical properties and unfolding pathway of the four-helix acyl-CoA binding protein (ACBP). Contrary to previous studies which have shown protein native states to be brittle, we observed extraordinary compliance for ACBP along two orthogonal pulling axis, with...

  17. Sample preparation for single molecule localization microscopy.

    Allen, John R; Ross, Stephen T; Davidson, Michael W

    2013-11-21

    Single molecule localization-based optical nanoscopy was introduced in 2006, surpassing traditional diffraction-limited resolutions by an order of magnitude. Seven years later, this superresolution technique is continuing to follow a trend of increasing popularity and pervasiveness, with the proof-of-concept work long finished and commercial implementations now available. However one important aspect that tends to become lost in translation is the importance of proper sample preparation, with very few resources addressing the considerations that must be made when preparing samples for imaging with single molecule level sensitivity. Presented here is a an in-depth analysis of all aspects of sample preparation for single molecule superresolution, including both live and fixed cell preparation, choice of fluorophore, fixation and staining techniques, and imaging buffer considerations. PMID:24084850

  18. Exploring patterns in European singles charts

    Buda, Andrzej

    2015-01-01

    European singles charts are important part of the music industry responsible for creating popularity of songs. After modeling and exploring dynamics of global album sales in previous papers, we investigate patterns of hit singles popularity according to all data (1966-2015) from weekly charts (polls) in 12 Western European countries. The dynamics of building popularity in various national charts is more than the economy because it depends on spread of information. In our research we have shown how countries may be affected by their neighbourhood and influenced by technological era. We have also computed correlations with geographical and cultural distances between countries in analog, digital and Internet era. We have shown that time delay between the single premiere and the peak of popularity has become shorter under the influence of technology and the popularity of songs depends on geographical distances in analog (1966-1987) and Internet (2004-2015) era. On the other hand, cultural distances between nation...

  19. THE BERTRAND MODEL OF THE SINGLE MARKET

    Vadasan Ioana

    2010-12-01

    Full Text Available Starting with the signification of the rationality hypothesis when the agent’s contentment is directly affected by the other agents’ decisions, the theory of games defines solutions for solving different situations of conflict. The economic actors have different behaviours of the Single Market. Oligopoly strategic behaviours were analysed by the Bertrand model. The two types revealed in the work show that strategic interactions are sensitive to the companies’ features, products and markets. Regarding the situation when we have an oligopoly competition, the companies make interdependent decisions in the environment affected by risk and uncertainty of the Single Market. For this reason it is an opportunity to study the structure of oligopoly type of of the Single Market with the aid of non – cooperative games.

  20. Anisotropic Shock Propagation in Single Crystals

    Eggert, J; Hicks, D; Celliers, P; Bradley, D; Cox, J; Unites, W; Collins, G; McWilliams, R; Jeanloz, R; Bruygoo, S; Loubeyre, P

    2005-05-26

    Most single-crystal shock experiments have been performed in high-symmetry directions while the nature of shock propagation in low-symmetry directions remains relatively unstudied. It is well known that small-amplitude, linear acoustic waves propagating in low-symmetry directions can focus and/or form caustics (Wolfe, 1995). In this report we provide evidence for similar focusing behavior in nonlinear (shock) waves propagating in single crystals of silicon and diamond. Using intense lasers, we have driven non-planar (divergent geometry) shock waves through single-crystals of silicon or diamond and into an isotropic backing plate. On recovery of the backing plates we observe a depression showing evidence of anisotropic plastic strain with well-defined crystallographic registration. We observe 4-, 2-, and 3-fold symmetric impressions for [100], [110], and [111] oriented crystals respectively.

  1. What are single photons good for?

    Sangouard, Nicolas; Zbinden, Hugo

    2012-10-01

    In a long-held preconception, photons play a central role in present-day quantum technologies. But what are sources producing photons one by one good for precisely? Well, in opposition to what many suggest, we show that single-photon sources are not helpful for point to point quantum key distribution because faint laser pulses do the job comfortably. However, there is no doubt about the usefulness of sources producing single photons for future quantum technologies. In particular, we show how single-photon sources could become the seed of a revolution in the framework of quantum communication, making the security of quantum key distribution device-independent or extending quantum communication over many hundreds of kilometers. Hopefully, these promising applications will provide a guideline for researchers to develop more and more efficient sources, producing narrowband, pure and indistinguishable photons at appropriate wavelengths.

  2. What are single photons good for?

    Sangouard, Nicolas

    2012-01-01

    In a long-held preconception, photons play a central role in present-day quantum technologies. But what are sources producing photons one by one good for precisely? Well, in opposition to what many suggest, we show that single-photon sources are not helpful for point to point quantum key distribution because faint laser pulses do the job comfortably. However, there is no doubt about the usefulness of sources producing single photons for future quantum technologies. In particular, we show how single-photon sources could become the seed of a revolution in the framework of quantum communication, making the security of quantum key distribution device independent or extending quantum communication over many hundreds of kilometers. Hopefully, these promising applications will provide a guideline for researchers to develop more and more efficient sources, producing narrowband, pure and indistinguishable photons at appropriate wavelengths.

  3. Single top quark production with CMS

    Mitra, Soureek

    2016-01-01

    Measurements of single top quark production are presented, performed using CMS data collected in 2011, 2012 and 2015 at centre-of-mass energies of 7, 8 and 13 TeV respectively. The cross sections for the electroweak production of single top quarks in the t-channel and in association with W-bosons is measured and the results are used to place constraints on the CKM matrix element Vtb. In the t-channel the ratio of top and anti-top production cross sections is determined and compared with predictions from different parton density distribution functions. In the same channel, the inclusive cross-section in the fiducial volume is also measured. Measurements of top quark properties in single top quark production such as the top-quark polarisation, W-helicity in top quark decay and searches for anomalous couplings to gluons, photons are also presented,. A search for the s-channel is also performed.

  4. Unparticle physics in single top signals

    Alan, A.T.; Senol, A. [Abant Izzet Baysal Univ., Dept. of Physics (Turkey); Pak, N.K. [Middle East Technical Univ., Dept. of Physics, Ankara (Turkey)

    2008-07-15

    A new scheme has been recently proposed, it is based on the existence of a non-trivial scale-invariant sector at a much higher scale than that of the standard model. This sector might couple to standard model fields via non-renormalizable effective interactions involving invisible massless objects of fractional scale dimension, dubbed as unparticles. We study the single production of top quarks in e{sup +}e{sup -}, ep and pp collisions in the context of unparticle physics through the flavor violating unparticle vertices and compute the total cross-sections for single top production as functions of scale dimension. We show that among all, LHC is the most promising facility to probe the unparticle physics via single top quark production processes.

  5. Tunable unidirectional scattering of ellipsoidal single nanoparticle

    Reena, Kalra, Yogita; Kumar, Ajeet; Sinha, R. K.

    2016-06-01

    We report unidirectional scattering by tri-axial single ellipsoidal dielectric nanoparticle, which is applicable in the design and development of tunable, low-loss and ultra-compact nanoantennas. Based on the orientation and rotation of the ellipsoidal nanoparticle, three types of modes, one longitudinal mode and two transverse modes, have been excited. Electric and magnetic dipoles have been optically induced in the nanoparticle. Generalized Kerker's conditions have been applied at the interference of optically induced electric and magnetic dipoles. Azimuthally symmetric forward scattering with complete suppression of backward scattering using first Generalized Kerker's condition has been achieved at three different wavelengths for the allowed longitudinal mode and transverse modes in the optical region using single ellipsoidal nanoparticle. Due to 3-fold symmetry, forward scattering can be tuned at different wavelengths, using single ellipsoidal nanoparticle just by changing the direction of the incident electric field.

  6. Single-Molecule Studies in Live Cells

    Yu, Ji

    2016-05-01

    Live-cell single-molecule experiments are now widely used to study complex biological processes such as signal transduction, self-assembly, active trafficking, and gene regulation. These experiments' increased popularity results in part from rapid methodological developments that have significantly lowered the technical barriers to performing them. Another important advance is the development of novel statistical algorithms, which, by modeling the stochastic behaviors of single molecules, can be used to extract systemic parameters describing the in vivo biochemistry or super-resolution localization of biological molecules within their physiological environment. This review discusses recent advances in experimental and computational strategies for live-cell single-molecule studies, as well as a selected subset of biological studies that have utilized these new technologies.

  7. Gated Mode Superconducting Nanowire Single Photon Detectors

    Akhlaghi, Mohsen K

    2011-01-01

    Single Photon Detectors (SPD) are fundamental to quantum optics and quantum information. Superconducting Nanowire SPDs (SNSPD) [1] provide high performance in terms of quantum efficiency (QE), dark count rate (DCR) and timing jitter [2], but have limited maximum count rate (MCR) when operated as a free-running mode (FM) detector [3, 4]. However, high count rates are needed for many applications like quantum computing [5] and communication [6], and laser ranging [7]. Here we report the first operation of SNSPDs in a gated mode (GM) that exploits a single photon triggered latching phenomenon to detect photons. We demonstrate operation of a large active area single element GM-SNSPD at 625MHz, one order of magnitude faster than its FM counterpart. Contrary to FM-SNSPDs, the MCR in GM can be pushed to GHz range without a compromise on the active area or QE, while reducing the DCR.

  8. General formalism for singly thermostated Hamiltonian dynamics.

    Ramshaw, John D

    2015-11-01

    A general formalism is developed for constructing modified Hamiltonian dynamical systems which preserve a canonical equilibrium distribution by adding a time evolution equation for a single additional thermostat variable. When such systems are ergodic, canonical ensemble averages can be computed as dynamical time averages over a single trajectory. Systems of this type were unknown until their recent discovery by Hoover and colleagues. The present formalism should facilitate the discovery, construction, and classification of other such systems by encompassing a wide class of them within a single unified framework. This formalism includes both canonical and generalized Hamiltonian systems in a state space of arbitrary dimensionality (either even or odd) and therefore encompasses both few- and many-particle systems. Particular attention is devoted to the physical motivation and interpretation of the formalism, which largely determine its structure. An analogy to stochastic thermostats and fluctuation-dissipation theorems is briefly discussed. PMID:26651677

  9. Quantification of circadian rhythms in single cells.

    Pål O Westermark

    2009-11-01

    Full Text Available Bioluminescence techniques allow accurate monitoring of the circadian clock in single cells. We have analyzed bioluminescence data of Per gene expression in mouse SCN neurons and fibroblasts. From these data, we extracted parameters such as damping rate and noise intensity using two simple mathematical models, one describing a damped oscillator driven by noise, and one describing a self-sustained noisy oscillator. Both models describe the data well and enabled us to quantitatively characterize both wild-type cells and several mutants. It has been suggested that the circadian clock is self-sustained at the single cell level, but we conclude that present data are not sufficient to determine whether the circadian clock of single SCN neurons and fibroblasts is a damped or a self-sustained oscillator. We show how to settle this question, however, by testing the models' predictions of different phases and amplitudes in response to a periodic entrainment signal (zeitgeber.

  10. Single Mode Fiber Optic Connectors And Splices

    Woods, John G.

    1984-08-01

    There is a trend toward increasing use of single mode transmission, particularly in telecommunications where high data bit rates are transmitted for long distances. Inter-connections of multimode fibers can be made in a number of ways, using ferrules, v-grooves, elastomeric splices, etc. However, the connection of single mode fibers, which have core diameters of 4 to 13 μm, requires more precise alignment than do the multimode fibers having core diameters of 50 μm or more. At TRW, we have adapted the four rod alignment guide concept for single mode fiber inter-connections. The principle of this OPTAGUIDE* alignment guide is presented. The single mode connectors and splices use the four rod scheme with an index matching material to eliminate or reduce the losses incurred through fiber end roughness or angularity. We are able to produce demountable connectors for 80/4.4 pm fibers having typical insertion losses of 1.0dB. The main factors in obtaining this result are the naturally precise fiber alignment provided by the alignment guide, and the ability of several manufacturers to maintain tight diametral and core offset tolerances. The single mode OPTALIGN* SM Connectors have been subjected to performance and environmental tests including repeated matings, temperature cycle and vibration. The results of these tests are described in this paper. A feature of the OPTALIGN* SM Connectors is the relative ease and speed of attachment to fiber optic cable in the field, without the use of epoxy or polishing procedures. The alignment guide concept has also been applied to permanent single mode splices. The splicing procedure is simple to perform in the field without expensive or delicate equipment. Construction and assembly procedures of the demountable connectors and permanent splices will be described with the aid of diagrams and photographs.

  11. Single-pixel complementary compressive sampling spectrometer

    Lan, Ruo-Ming; Liu, Xue-Feng; Yao, Xu-Ri; Yu, Wen-Kai; Zhai, Guang-Jie

    2016-05-01

    A new type of compressive spectroscopy technique employing a complementary sampling strategy is reported. In a single sequence of spectral compressive sampling, positive and negative measurements are performed, in which sensing matrices with a complementary relationship are used. The restricted isometry property condition necessary for accurate recovery of compressive sampling theory is satisfied mathematically. Compared with the conventional single-pixel spectroscopy technique, the complementary compressive sampling strategy can achieve spectral recovery of considerably higher quality within a shorter sampling time. We also investigate the influence of the sampling ratio and integration time on the recovery quality.

  12. Coupling single emitters to quantum plasmonic circuits

    Huck, Alexander

    2016-01-01

    In recent years the controlled coupling of single photon emitters to propagating surface plasmons has been intensely studied, which is fueled by the prospect of a giant photonic non-linearity on a nano-scaled platform. In this article we will review the recent progress on coupling single emitters to nano-wires towards the construction of a new platform for strong light-matter interaction. The control over such a platform might open new doors for quantum information processing and quantum sensing at the nanoscale, and for the study of fundamental physics in the ultra-strong coupling regime.

  13. Luminescence investigation of zinc molybdate single crystals

    Zinc molybdate is considered as an alternative to the sheelite-type molybdate crystals for cryogenic scintillating bolometers. We report the results of the first investigation of the luminescent properties of bulk ZnMoO4 single crystals grown by Czochralski method. The temperature dependence of the luminescence intensity under different excitation energies was studied, optical characteristics of zinc molybdate are presented. The potential of ZnMoO4 single crystal as a scintillating material at low temperature is demonstrated. (copyright 2009 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  14. Interfacing superconducting qubits and single optical photons

    Das, Sumanta; Sørensen, Anders S

    2016-01-01

    We propose an efficient light-matter interface at optical frequencies between a superconducting qubit and a single photon. The desired interface is based on a hybrid architecture composed of an organic molecule embedded inside an optical waveguide and electrically coupled to a superconducting qubit far from the optical axis. We show that high fidelity, photon-mediated, entanglement between distant superconducting qubits can be achieved with incident pulses at the single photon level. Such low light level is highly sought for to overcome the decoherence of the superconducting qubit caused by absorption of optical photons.

  15. Superconducting Quantum Interference Single-Electron Transistor

    Enrico, Emanuele; Giazotto, Francesco

    2016-06-01

    We propose the concept of a quantized single-electron source based on the interplay between Coulomb blockade and magnetic flux-controllable superconducting proximity effect. We show that flux dependence of the induced energy gap in the density of states of a nanosized metallic wire can be exploited as an efficient tunable energy barrier which enables charge-pumping configurations with enhanced functionalities. This control parameter strongly affects the charging landscape of a normal metal island with non-negligible Coulombic energy. Under a suitable evolution of a time-dependent magnetic flux the structure behaves like a turnstile for single electrons in a fully electrostatic regime.

  16. Route to intense single attosecond pulses

    Tsakiris, George D.; Eidmann, Klaus; Meyer-ter-Vehn, Jürgen; Krausz, Ferenc

    2006-02-01

    A feasibility study is presented for the generation of single attosecond pulses using harmonics produced by planar targets irradiated at high intensities. The investigation focuses on the interaction of a few-optical cycles, carrier-envelope phase controlled, near-infrared laser pulse with an overdense plasma. The results obtained using an one-dimensional particle-in-cell code indicate that at laser intensities of 1020 W cm-2 a single sub-fs pulse can be generated in the 20 70 eV spectral range with an efficiency of a few per cent and with 10-3 to 10-4 for higher photon energies.

  17. Route to intense single attosecond pulses

    A feasibility study is presented for the generation of single attosecond pulses using harmonics produced by planar targets irradiated at high intensities. The investigation focuses on the interaction of a few-optical cycles, carrier-envelope phase controlled, near-infrared laser pulse with an overdense plasma. The results obtained using an one-dimensional particle-in-cell code indicate that at laser intensities of 1020 W cm-2 a single sub-fs pulse can be generated in the 20-70 eV spectral range with an efficiency of a few per cent and with 10-3 to 10-4 for higher photon energies

  18. Single Molecule Biophysics Experiments and Theory

    Komatsuzaki, Tamiki; Takahashi, Satoshi; Yang, Haw; Silbey, Robert J; Rice, Stuart A; Dinner, Aaron R

    2011-01-01

    Discover the experimental and theoretical developments in optical single-molecule spectroscopy that are changing the ways we think about molecules and atoms The Advances in Chemical Physics series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. This latest volume explores the advent of optical single-molecule spectroscopy, and how atomic force microscopy has empowered novel experiments on individual biomolecules, opening up new frontiers in molecular and cell biology and leading to new theoretical approaches

  19. Generation of Single, Monodisperse Compound Droplets

    Black, James

    2010-01-01

    The generation of single, monodisperse compound droplets is shown in these fluid dynamics videos. In an apparatus designed to produce single compound droplets, a piezoelectric diaphragm generates a pressure pulse from a voltage waveform input to eject a droplet. In the method presented, oil is allowed to flow into the water nozzle with the pressure pulse ejecting both fluids as a compound droplet. Experiments were performed to demonstrate how changes in water pressure affect compound droplet compositions. It was found that increasing the water pressure decreased the thickness of the compound droplet's oil layer.

  20. Single Particle X-ray Diffractive Imaging

    Bogan, M J; Benner, W H; Boutet, S; Rohner, U; Frank, M; Seibert, M; Maia, F; Barty, A; Bajt, S; Riot, V; Woods, B; Marchesini, S; Hau-Riege, S P; Svenda, M; Marklund, E; Spiller, E; Hajdu, J; Chapman, H N

    2007-10-01

    In nanotechnology, strategies for the creation and manipulation of nanoparticles in the gas phase are critically important for surface modification and substrate-free characterization. Recent coherent diffractive imaging with intense femtosecond X-ray pulses has verified the capability of single-shot imaging of nanoscale objects at sub-optical resolutions beyond the radiation-induced damage threshold. By intercepting electrospray-generated particles with a single 15 femtosecond soft-X-ray pulse, we demonstrate diffractive imaging of a nanoscale specimen in free flight for the first time, an important step toward imaging uncrystallized biomolecules.

  1. Luminescence investigation of zinc molybdate single crystals

    Vasil' ev, Andrey [Skobeltsyn Institute of Nuclear Physics, M. V. Lomonosov Moscow State University (Russian Federation); Kamenskikh, Irina; Kolobanov, Vitaly; Savon, Alexander [Synchrotron Radiation Laboratory, Physics Faculty, Moscow State University (Russian Federation); Mikhailin, Vitaly [Skobeltsyn Institute of Nuclear Physics, M. V. Lomonosov Moscow State University (Russian Federation); Synchrotron Radiation Laboratory, Physics Faculty, Moscow State University (Russian Federation); Ivleva, Ludmila; Voronina, Irina; Berezovskaya, Ludmila [A. M. Prokhorov General Physics Institute of RAS, Moscow (Russian Federation); Spassky, Dmitry

    2009-07-15

    Zinc molybdate is considered as an alternative to the sheelite-type molybdate crystals for cryogenic scintillating bolometers. We report the results of the first investigation of the luminescent properties of bulk ZnMoO{sub 4} single crystals grown by Czochralski method. The temperature dependence of the luminescence intensity under different excitation energies was studied, optical characteristics of zinc molybdate are presented. The potential of ZnMoO{sub 4} single crystal as a scintillating material at low temperature is demonstrated. (copyright 2009 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  2. Friction stir welding of single crystal aluminium

    Fonda, Richard Warren; Wert, John A.; Reynolds, A.P.;

    2007-01-01

    Friction stir welds were prepared in different orientations in an aluminium single crystal. The welds were quenched to preserve the microstructure surrounding the tool and then electron backscattered diffraction was used to reveal the generation of grain boundaries and the evolution of...... crystallographic texture around the tool in each weld. The extent of both dynamic recrystallisation and conventional recrystallisation varied considerably as a function of weld orientation. As the base plate begins to interact with the deformation field surrounding the tool, regions of the single crystal rotate to...

  3. Single-Trial Inference on Visual Attention

    Dyrholm, Mads; Kyllingsbæk, Søren; Vangkilde, Signe Allerup;

    2011-01-01

    In this paper we take a step towards single-trial behavioral modeling within a Theory of Visual Attention (TVA). In selective attention tasks, such as the Partial Report paradigm, the subject is asked to ignore distractors and only report stimuli that belong to the target class. Nothing about a...... Report trial. This result retrodicts a latent attentional state of the subject using the observed response from that particular trial and thus differs from other predictions made with TVA which are based on expected values of observed variables. We show an example of the result in single-trial analysis...

  4. Single-Trial Inference on Visual Attention

    Dyrholm, Mads; Kyllingsbæk, Søren; Vangkilde, Signe Allerup;

    In this paper we take a step towards single-trial behavioral modeling within a Theory of Visual Attention (TVA). In selective attention tasks, such as the Partial Report paradigm, the subject is asked to ignore distractors and only report stimuli that belong to the target class. Nothing about a...... Report trial. This result retrodicts a latent attentional state of the subject using the observed response from that particular trial and thus differs from other predictions made with TVA which are based on expected values of observed variables. We show an example of the result in single-trial analysis...

  5. Electron impact single ionization of copper

    L K Jha; O P Roy; B N Roy

    2000-09-01

    Electron impact single ionization cross sections of copper have been calculated in the binary encounter approximation using accurate expression for as given by Vriens and Hartree–Fock momentum distribution for the target electron. The BEA calculation based on the usual procedure does not show satisfactory agreement with experiment in this case but a striking modification is found to be successful in explaining the experimental observations. The discrepancy is linked with the ionization of the 310 electrons and probably effective single ionization does not take place from 3 shell of copper leading to smaller values of experimental cross sections.

  6. Automated single-slide staining device

    Wilkins, J. R.; Mills, S. M. (Inventor)

    1977-01-01

    A simple apparatus and method is disclosed for making individual single Gram stains on bacteria inoculated slides to assist in classifying bacteria in the laboratory as Gram-positive or Gram-negative. The apparatus involves positioning a single inoculated slide in a stationary position and thereafter automatically and sequentially flooding the slide with increments of a primary stain, a mordant, a decolorizer, a counterstain and a wash solution in a sequential manner without the individual lab technician touching the slide and with minimum danger of contamination thereof from other slides.

  7. Some Effects on A Single Particle Energies

    WANG Qiu-Ling; LUO Yan-An; CAI Chong-Hai; NING Ping-Zhi

    2002-01-01

    With the phenomenological A-nucleus potentials of Woods-Saxon shape,the effects of the maas-number dependence of the shrinkage,the effective mass m*^ and the charge-symmetry breaking (CSB) on the single particle energies are discussed.It is found that the single particle energies are not sensitive to the effective mass m*^.But the radius parameter depended on the mass number (ro (Ac) = r1 + r2A-2/3) can substantially improve the results.We also found that CSB effect is significant for heavy hypernuclei with a large neutron excess.

  8. 78 FR 75897 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

    2013-12-13

    ... Parts 4022 and 4044 Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single... regulations on Benefits Payable in Terminated Single- Employer Plans and Allocation of Assets in Single... Allocation of Assets in Single-Employer Plans (29 CFR Part 4044) and Benefits Payable in Terminated...

  9. 34 CFR 403.82 - In what settings may the Single Parents, Displaced Homemakers, and Single Pregnant Women Program...

    2010-07-01

    ... Homemakers, and Single Pregnant Women Program be offered? 403.82 Section 403.82 Education Regulations of the... Secretary Assist Under the Basic Programs? Single Parents, Displaced Homemakers, and Single Pregnant Women Program § 403.82 In what settings may the Single Parents, Displaced Homemakers, and Single Pregnant...

  10. Sex Differences in Parenting Behaviors in Single-Mother and Single-Father Households

    Dufur, Mikaela J.; Howell, Nyssa C.; Downey, Douglas B.; Ainsworth, James W.; Lapray, Alice J.

    2010-01-01

    Research on family structure has led some to claim that sex-based parenting differences exist. But if such differences exist in single-parent families, the absence of a second parent rather than specific sex-typed parenting might explain them. We examine differences in mothering and fathering behavior in single-parent households, where number of…

  11. Direct imaging of single UvrD helicase dynamics on long single-stranded DNA.

    Lee, Kyung Suk; Balci, Hamza; Jia, Haifeng; Lohman, Timothy M; Ha, Taekjip

    2013-01-01

    Fluorescence imaging of single-protein dynamics on DNA has been largely limited to double-stranded DNA or short single-stranded DNA. We have developed a hybrid approach for observing single proteins moving on laterally stretched kilobase-sized ssDNA. Here we probed the single-stranded DNA translocase activity of Escherichia coli UvrD by single fluorophore tracking, while monitoring DNA unwinding activity with optical tweezers to capture the entire sequence of protein binding, single-stranded DNA translocation and multiple pathways of unwinding initiation. The results directly demonstrate that the UvrD monomer is a highly processive single-stranded DNA translocase that is stopped by a double-stranded DNA, whereas two monomers are required to unwind DNA to a detectable degree. The single-stranded DNA translocation rate does not depend on the force applied and displays a remarkable homogeneity, whereas the unwinding rate shows significant heterogeneity. These findings demonstrate that UvrD assembly state regulates its DNA helicase activity with functional implications for its stepping mechanism, and also reveal a previously unappreciated complexity in the active species during unwinding. PMID:23695672

  12. Voting in general elections on single day and in single phase

    varma, Vijaya krushna varma

    2014-01-01

    This expanded banking system will help the Election Commission conduct voting in General elections on single day and in single phase. All elections from panchayats to Parliament can be conducted with the help of expanded banking system with minimum cost and without rigging and impersonate voting.

  13. Single Molecule Analysis Research Tool (SMART: an integrated approach for analyzing single molecule data.

    Max Greenfeld

    Full Text Available Single molecule studies have expanded rapidly over the past decade and have the ability to provide an unprecedented level of understanding of biological systems. A common challenge upon introduction of novel, data-rich approaches is the management, processing, and analysis of the complex data sets that are generated. We provide a standardized approach for analyzing these data in the freely available software package SMART: Single Molecule Analysis Research Tool. SMART provides a format for organizing and easily accessing single molecule data, a general hidden Markov modeling algorithm for fitting an array of possible models specified by the user, a standardized data structure and graphical user interfaces to streamline the analysis and visualization of data. This approach guides experimental design, facilitating acquisition of the maximal information from single molecule experiments. SMART also provides a standardized format to allow dissemination of single molecule data and transparency in the analysis of reported data.

  14. Method for forming single phase, single crystalline 2122 BCSCO superconductor thin films by liquid phase epitaxy

    Pandey, Raghvendra K. (Inventor); Raina, Kanwal (Inventor); Solayappan, Narayanan (Inventor)

    1994-01-01

    A substantially single phase, single crystalline, highly epitaxial film of Bi.sub.2 CaSr.sub.2 Cu.sub.2 O.sub.8 superconductor which has a T.sub.c (zero resistance) of 83 K is provided on a lattice-matched substrate with no intergrowth. This film is produced by a Liquid Phase Epitaxy method which includes the steps of forming a dilute supercooled molten solution of a single phase superconducting mixture of oxides of Bi, Ca, Sr, and Cu having an atomic ratio of about 2:1:2:2 in a nonreactive flux such as KCl, introducing the substrate, e.g., NdGaO.sub.3, into the molten solution at 850.degree. C., cooling the solution from 850.degree. C. to 830.degree. C. to grow the film and rapidly cooling the substrate to room temperature to maintain the desired single phase, single crystalline film structure.

  15. Single ricin detection by AFM chemomechanical mapping

    This research reports a method of detecting ricin molecules immobilized on chemically modified gold (Au;111) surface by chemomechanically mapping the molecular interactions with a chemically modified Atomic Force Microscope (AFM) tip. AFM images resolved the different fold-up conformations of single...

  16. CHARACTERISTICS OF SINGLE PARTICLE COAL COMBUSTION

    The paper discusses the measurement of the burning history of single coal particles, using a two-color optical pyrometer. rom intensity traces at two wavelengths, information on burning times and temperatures, the duration of a volatile flame, and projected areas was obtained for...

  17. Aortic valve annuloplasty: new single suture technique.

    Schöllhorn, Joachim; Rylski, Bartosz; Beyersdorf, Friedhelm

    2014-06-01

    Reconstruction strategies for aortic valve insufficiency in the presence of aortic annulus dilatation are usually surgically challenging. We demonstrate a simple, modified Taylor technique of downsizing and stabilization of the aortic annulus using a single internal base suture. Since April 2011, 22 consecutive patients have undergone safe aortic valve annuloplasty. No reoperations for aortic valve insufficiency and no deaths occurred. PMID:24882316

  18. Single-Case Designs Technical Documentation

    Kratochwill, T. R.; Hitchcock, J.; Horner, R. H.; Levin, J. R.; Odom, S. L.; Rindskopf, D. M; Shadish, W. R.

    2010-01-01

    In an effort to expand the pool of scientific evidence available for review, the What Works Clearinghouse (WWC) assembled a panel of national experts in single-case design (SCD) and analysis to draft SCD Standards. SCDs are adaptations of interrupted time-series designs and can provide a rigorous experimental evaluation of intervention effects.…

  19. Tuneable graphene nanopores for single biomolecule detection.

    Al-Dirini, Feras; Mohammed, Mahmood A; Hossain, Md Sharafat; Hossain, Faruque M; Nirmalathas, Ampalavanapillai; Skafidas, Efstratios

    2016-05-21

    Solid-state nanopores are promising candidates for next generation DNA and protein sequencing. However, once fabricated, such devices lack tuneability, which greatly restricts their biosensing capabilities. Here we propose a new class of solid-state graphene-based nanopore devices that exhibit a unique capability of self-tuneability, which is used to control their conductance, tuning it to levels comparable to the changes caused by the translocation of a single biomolecule, and hence, enabling high detection sensitivities. Our presented quantum simulation results suggest that the smallest amino acid, glycine, when present in water and in an aqueous saline solution can be detected with high sensitivity, up to a 90% change in conductance. Our results also suggest that passivating the device with nitrogen, making it an n-type device, greatly enhances its sensitivity, and makes it highly sensitive to not only the translocation of a single biomolecule, but more interestingly to intramolecular electrostatics within the biomolecule. Sensitive detection of the carboxyl group within the glycine molecule, which carries a charge equivalent to a single electron, is achieved with a conductance change that reaches as high as 99% when present in an aqueous saline solution. The presented findings suggest that tuneable graphene nanopores, with their capability of probing intramolecular electrostatics, could pave the way towards a new generation of single biomolecule detection devices. PMID:27171594

  20. Dose optimisation in single plane interstitial brachytherapy

    Tanderup, Kari; Hellebust, Taran Paulsen; Honoré, Henriette H;

    2006-01-01

    BACKGROUND AND PURPOSE: Brachytherapy dose distributions can be optimised       by modulation of source dwell times. In this study dose optimisation in       single planar interstitial implants was evaluated in order to quantify the       potential benefit in patients. MATERIAL AND METHODS: In 14...

  1. Theory of Single Point Incremental Forming

    Martins, P.A.F.; Bay, Niels; Skjødt, Martin;

    2008-01-01

    This paper presents a closed-form theoretical analysis modelling the fundamentals of single point incremental forming and explaining the experimental and numerical results available in the literature for the past couple of years. The model is based on membrane analysis with bi-directional in...

  2. Production amplitude for a single scalar resonance

    We derive a simple expression for the production amplitude of two pseudoscalar mesons involving a single scalar resonance. This amplitude is determined by a combination of Watson's phase δ(s) and another phase ω(s), related to an unambiguous two-meson propagator. With a lagrangian model, we study the σππ system

  3. Congenital malformation of inner ear, single cavity

    Congenital malformations of the inner ear are rare conditions, but their detection requires high diagnostic accuracy. In this report we describe the case of a patient with single or common cavity, discuss the corresponding radiological images, describe the treatment of this patient with a cochlear implant, and review the classification and differential diagnosis of the other anomalies of the inner ear.

  4. High-Performance Single Nanowire Tunnel Diodes

    Wallentin, Jesper; Persson, Johan Mikael; Wagner, Jakob Birkedal;

    2010-01-01

    We demonstrate single nanowire tunnel diodes with room temperature peak current densities of up to 329 A/cm(2). Despite the large surface to volume ratio of the type-II InP-GaAs axial heterostructure nanowires, we measure peak to valley current ratios (PVCR) of up to 8.2 at room temperature and 2...

  5. Unvented single stack sanitary drainage system I

    Najman, Z.

    This report forms the basis of the preparation of design recommendations. In the observation tables all single results from 147 tests of charging are dispersed on 53 test set-ups. At test set-ups in 1 till 4 floors height discharge pipes with dimensions of 100, 125, and 150 mm were tested with di...

  6. An introduction to single implant abutments.

    Warreth, Abdulhadi

    2013-01-01

    This article is an introduction to single implant abutments and aims to provide basic information about abutments which are essential for all dental personnel who are involved in dental implantology. Clinical Relevance: This article provides a basic knowledge of implants and implant abutments which are of paramount importance, as replacement of missing teeth with oral implants has become a well-established clinical procedure.

  7. Discovery of single top quark production

    Gillberg, Dag

    2011-01-01

    The top quark is by far the heaviest known fundamental particle with a mass nearing that of a gold atom. Because of this strikingly high mass, the top quark has several unique properties and might play an important role in electroweak symmetry breaking—the mechanism that gives all elementary particles mass. Creating top quarks requires access to very high energy collisions, and at present only the Tevatron collider at Fermilab is capable of reaching these energies. Until now, top quarks have only been observed produced in pairs via the strong interaction. At hadron colliders, it should also be possible to produce single top quarks via the electroweak interaction. Studies of single top quark production provide opportunities to measure the top quark spin, how top quarks mix with other quarks, and to look for new physics beyond the standard model. Because of these interesting properties, scientists have been looking for single top quarks for more than 15 years. This thesis presents the first discovery of singl...

  8. Information processing at single neuron level

    Vidybida, A. K.

    2007-01-01

    Based on numerical simulation of Hodgkin and Huxley type neuron stimulated from many synaptic inputs, an abstract concept of signal processing in individual neuron is proposed. In the concept proposed, neuron performs binding of synaptic inputs into a single output event, based on the degree of temporal coherence between the inputs. Inhibition serves as controlling factor of this type of binding.

  9. Single-electronic radio-frequency refrigerator.

    Kafanov, S; Kemppinen, A; Pashkin, Yu A; Meschke, M; Tsai, J S; Pekola, J P

    2009-09-18

    We demonstrate experimentally that a hybrid single-electron transistor with superconducting leads and a normal-metal island can be refrigerated by an alternating voltage applied to the gate electrode. The simultaneous measurement of the dc current induced by the rf gate through the device at a small bias voltage serves as an in situ thermometer. PMID:19792419

  10. Quantum sensors based on single diamond defects

    NV centers in diamond are promising sensors able to detect electric and magnetic fields at nanoscale. Here we report on the detection of biomolecules using magnetic noise induced by their electron and nuclear spins. Presented results show first steps towards establishing novel sensing technology for visualizing single proteins and study of their dynamics. (author)

  11. Nanomechanics of Single Crystalline Tungsten Nanowires

    Volker Cimalla

    2008-01-01

    Full Text Available Single crystalline tungsten nanowires were prepared from directionally solidified NiAl-W alloys by a chemical release from the resulting binary phase material. Electron back scatter diffraction (EBSD proves that they are single crystals having identical crystallographic orientation. Mechanical investigations such as bending tests, lateral force measurements, and mechanical resonance measurements were performed on 100–300 nm diameter wires. The wires could be either directly employed using micro tweezers, as a singly clamped nanowire or in a doubly clamped nanobridge. The mechanical tests exhibit a surprisingly high flexibility for such a brittle material resulting from the small dimensions. Force displacement measurements on singly clamped W nanowires by an AFM measurement allowed the determination of a Young's modulus of 332 GPa very close to the bulk value of 355 GPa. Doubly clamped W nanowires were employed as resonant oscillating nanowires in a magnetomotively driven resonator running at 117 kHz. The Young's modulus determined from this setup was found to be higher 450 GPa which is likely to be an artefact resulting from the shift of the resonance frequency by an additional mass loading.

  12. From Single Market to Economic Union

    Bartalevich, Dzmitry

    2014-01-01

    Book review of: From Single Market to Economic Union: Essays in Memory of John A. Usher / edited by N.N. Shuibhne and L.W. Gormley (Oxford: Oxford University Press, 2012, ISBN 9780199695706); viii + 431pp., £75.00 hb....

  13. Nano-soldering to single atomic layer

    Girit, Caglar O.; Zettl, Alexander K.

    2011-10-11

    A simple technique to solder submicron sized, ohmic contacts to nanostructures has been disclosed. The technique has several advantages over standard electron beam lithography methods, which are complex, costly, and can contaminate samples. To demonstrate the soldering technique graphene, a single atomic layer of carbon, has been contacted, and low- and high-field electronic transport properties have been measured.

  14. Focusing a deterministic single-ion beam

    We focus down an ion beam consisting of single 40Ca+ ions to a spot size of a few micrometers using an einzel lens. Starting from a segmented linear Paul trap, we have implemented a procedure that allows us to deterministically load a predetermined number of ions by using the potential shaping capabilities of our segmented ion trap. For single-ion loading, an efficiency of 96.7(7)% has been achieved. These ions are then deterministically extracted out of the trap and focused down to a 1σ-spot radius of (4.6±1.3) μm at a distance of 257 mm from the trap center. Compared to previous measurements without ion optics, the einzel lens is focusing down the single-ion beam by a factor of 12. Due to the small beam divergence and narrow velocity distribution of our ion source, chromatic and spherical aberration at the einzel lens is vastly reduced, presenting a promising starting point for focusing single ions on their way to a substrate.

  15. Divorce, Single Parenting, and Child Development.

    Crossman, Sharyn M.; Adams, Gerald R.

    1980-01-01

    Investigated whether a preschool intervention program for children from single-parent households could be effective in establishing the conditions appropriate for allowing the child to recover from the harmful consequences of divorce and limited adult-child interaction. (Author/DB)

  16. Single-Parent Families: Myth and Reality

    Verzaro, Marce; Hennon, Charles B.

    1980-01-01

    Examines the myths surrounding single-parent families. Discusses lifestyles, parental roles, parent-child relationships, psychological development of the child, and how these concerns affect home economics programs (knowledge, skills, coping patterns, teaching methods, the role of 4-H, stereotypes, and teachers' communication with parents). (CT)

  17. Scalable dielectrophoresis of single walled carbon nanotubes

    Fitzhugh, William A.

    Single Walled Carbon Nanotubes (SWNTs) have attracted much attention as a candidate material for future nano-scale 'beyond silicon' devices. However industrial scale operations have been impeded by difficulties in separating the metallic and semiconducting species. This paper addresses the use of highly inhomogeneous alternating electric fields, dielectrophoresis, to isolate SWNT species in scaled systems. Both numerical and experimental methods will be discussed.

  18. Superconductivity in Single-Crystal YIn3

    Johnson, S D; Young, J. R.; Zieve, R. J.; Cooley, J. C.

    2011-01-01

    We measure the superconducting transition of YIn$_3$ by resistivity, susceptibility, and specific heat. Despite using high-quality single-crystal samples, the transitions detected by the three techniques are shifted from each other in temperature, suggesting a region of filamentary superconductivity. We discuss the possible implications for filamentary superconductivity in unconventional superconductors.

  19. Single Boson Realizations of the Higgs Algebra

    RUANDong; WUChu; SUNHong-Zhou

    2003-01-01

    We obtained for the Higgs algebra three kinds of single boson realizations such as the unitary Holstein-Primakoff-like realization, the non-unitary Dyson-like realization, and the unitary Villain-like realization. The corre-sponding similarity transformations between the Holstein-Primakoff-like realizations and the Dyson-like realizations are given.

  20. Single-mode biological distributed feedback laser

    Vannahme, Christoph; Maier-Flaig, Florian; Lemmer, Uli;

    2013-01-01

    Single-mode second order distributed feedback (DFB) lasers of riboflavin (vitamin B2) doped gelatine films on nanostructured low refractive index material are demonstrated. Manufacturing is based on a simple UV nanoimprint and spin-coating. Emission wavelengths of 543 nm and 562 nm for two...