Sustained spheromak technology

International Nuclear Information System (INIS)

Platts, D.A.; Sherwood, A.R.; Jarboe, T.R.; Linford, R.K.; Hoida, H.W.; Henins, I.

1984-01-01

The goal of these experiments is to devise a technique for driving a spheromak using dc-powered electrodes. The reduction or elimination of pulsed power components in the spheromak source would result in more attractive reactors, and simpler, cheaper experiments. This is important as experiments get larger and approach reactor size. According to some concepts, the dc spheromak would operate with plasma injection so that it would clean up any impurities produced during its formation. These features make the investigation of dc-powered spheromaks interesting. The questions that need to be answered in this investigation are: (1) can a spheromak be sustained by a dc source; and (2) can a practical source be designed to produce a hot clean plasma. After summarizing the evidence which suggests an answer to question one, the approach being taken to answer question two is discussed

Los Alamos Spheromak Program

International Nuclear Information System (INIS)

Knox, S.O.; Barnes, C.W.; Fernandez, J.C.

1985-01-01

The Los Alamos Spheromak Program consists of two experimental facilities. The confinement physics of sustained and decaying spheromaks are being studied in CTX, which has an extensive array of diagnostics. Experiments are directed towards extending the physics understanding of the spheromak as a magnetic confinement concept. Electrodes for the production of clean sustained spheromaks are developed on the Electrode Facility, which is more flexible in terms of experimental modifications. Improvements to helicity sources and elecrodes which are proven on the Electrode Facility are then considered for incorporation onto CTX

Theoretical issues in Spheromak research

International Nuclear Information System (INIS)

Cohen, R. H.; Hooper, E.B.; LoDestro, L.L.; Mattor, N.; Pearlstein, L.D.; Ryutov, D.D.

1997-01-01

This report summarizes the state of theoretical knowledge of several physics issues important to the spheromak. It was prepared as part of the preparation for the Sustained Spheromak Physics Experiment (SSPX), which addresses these goals: energy confinement and the physics which determines it; the physics of transition from a short-pulsed experiment, in which the equilibrium and stability are determined by a conducting wall (''''flux conserver'''') to one in which the equilibrium is supported by external coils. Physics is examined in this report in four important areas. The status of present theoretical understanding is reviewed, physics which needs to be addressed more fully is identified, and tools which are available or require more development are described. Specifically, the topics include: MHD equilibrium and design, review of MHD stability, spheromak dynamo, and edge plasma in spheromaks

Spheromak type plasma experiment apparatus

International Nuclear Information System (INIS)

Odagiri, Kiyoyuki; Miyauchi, Yasuyuki; Oomura, Hiroshi

1985-01-01

The fusion power reactor which is expected to be the most promising energy has been developed for several plasma confinement systems. Under these circumstances, Spheromak configuration has recently attracted attention because of its simple structure and efficient plasma confinement. This apparatus was ordered by the Engineering Department of University of Tokyo for basic studies of the Spheromak plasma confinement technologies. This forms Spheromak plasma according to the induction discharge system which injects this plasma with magnetic energy generated by a toroidal current in the plasma and discharges the current through the electrical feed through. Toroidal current is induced by the poloidal coil in the vessel. We worked together with the researchers of University of Tokyo to conduct experiments and confirmed the formation and confinement of Spheromak plasma in the initial test. (author)

Spheromak Physics Development

International Nuclear Information System (INIS)

Hooper, E.B.

1997-01-01

The spheromak is a Magnetic Fusion Energy (MFE) configuration, which is a leading alternative to the tokamak. It has a simple geometry which offers an opportunity to achieve the promise of fusion energy if the physics of confinement, current drive, and pressure holding capability extrapolate favorably to a reactor. Recent changes in the US MFE program, taken in response to budget constraints and programmatic directions from Congress, include a revitalization of an experimental alternative concept effort. Detailed studies of the spheromak were consequently undertaken to examine the major physics issues which need to be resolved to advance it as a fusion plasma, the optimum configuration for an advanced experiment, and its potential as a reactor. As a result of this study, we conclude that it is important to evaluate several physics issues experimentally. Such an experiment might be appropriately be named the Sustained Spheromak Physics Experiment (SSPX). It would address several critical issues, the solution to which will provide the physics basis to enable an advanced experiment. The specific scientific goals of SSPX would be to: * Demonstrate that electron and ion temperatures of a few hundred electron volts can be achieved in a steady-state spheromak plasma sustained by a magnetic dynamo (''helicity injection''). * Relate energy confinement quantitatively to the magnetic turbulence accompanying the dynamo and use this knowledge to optimize performance. * Measure the magnetic field profiles and magnetic turbulence in the plasma and relate these to the science of the magnetic dynamo which drives the current in the plasma. * Examine experimentally the pressure holding capability (''beta limit'') of the spheromak. * Understand the initial phases of the transition of the plasma from an equilibrium supported by a magnetic-flux conserving wall to one supported by external coils

A novel CDX2 isoform regulates alternative splicing.

Directory of Open Access Journals (Sweden)

Matthew E Witek

Full Text Available Gene expression is a dynamic and coordinated process coupling transcription with pre-mRNA processing. This regulation enables tissue-specific transcription factors to induce expression of specific transcripts that are subsequently amplified by alternative splicing allowing for increased proteome complexity and functional diversity. The intestine-specific transcription factor CDX2 regulates development and maintenance of the intestinal epithelium by inducing expression of genes characteristic of the mature enterocyte phenotype. Here, sequence analysis of CDX2 mRNA from colonic mucosa-derived tissues revealed an alternatively spliced transcript (CDX2/AS that encodes a protein with a truncated homeodomain and a novel carboxy-terminal domain enriched in serine and arginine residues (RS domain. CDX2 and CDX2/AS exhibited distinct nuclear expression patterns with minimal areas of co-localization. CDX2/AS did not activate the CDX2-dependent promoter of guanylyl cyclase C nor inhibit transcriptional activity of CDX2. Unlike CDX2, CDX2/AS co-localized with the putative splicing factors ASF/SF2 and SC35. CDX2/AS altered splicing patterns of CD44v5 and Tra2-β1 minigenes in Lovo colon cancer cells independent of CDX2 expression. These data demonstrate unique dual functions of the CDX2 gene enabling it to regulate gene expression through both transcription (CDX2 and pre-mRNA processing (CDX2/AS.

Spheromak Merging Experiments on SSX

Science.gov (United States)

Brown, M. R.; Kornack, T. W.; Sollins, P. K.; Luh, W. J.

1997-11-01

Spheromak merging experiments are underway at the Swarthmore Spheromak Experiment (SSX) at Swarthmore College. The spheromaks are formed by identical magnetized plasma guns and equilibrium is established in close fitting 0.5 m diameter copper flux conservers. Partial merging is achieved through openings in the back wall. We observe the formation of a reconnection boundary layer at the interface of the two spheromaks using a linear probe array. The characteristic scale of the flux reversal is about 1 cm (consistent with the diffusion scale δ_diff, the ion Larmor radius ρi and the ion inertial length c/ω_pi). Movies of the formation and evolution of the layer will be presented. Correlations between reconnection events and pulses of soft x-rays and energetic particles will be presented if available. Plans for 2D and 3D imaging of the layer will also be discussed.

Steady-state spheromak

International Nuclear Information System (INIS)

Jarboe, T.R.

1982-01-01

A major effort is being made in the national program to make the operation of axisymmetric, toroidal confinement systems steady state by the application of expensive rf current drive. Described here is a method by which such a confinement system, the spheromak, can be refluxed indefinitely through the application of dc power. As a step towards dc sustainment we have operated the present CTX source in the slow source mode with a longer power application time (approx. 0.1 ms) and successfully generated long-lived spheromaks. If the erosion of the electrodes can be controlled as well as it is with MPD arcs then dc operation should be very clean. If only a small fraction (approx. 10% for an experiment) of the poloidal flux of the spheromak connects to the source then the dc sustainment can be very efficient. The amount of connecting flux that is necessary for sustainment needs to be determined experimentally

Particle confinement and fueling effects on the Maryland spheromak

International Nuclear Information System (INIS)

Filuk, A.B.

1991-01-01

The spheromak plasma confinement concept provides the opportunity to study the evolution of a nearly force-free magnetic field configuration. The plasma currents and magnetic fields are produced self-consistently, making this type of device attractive as a possible fusion reactor. At present, spheromaks are observed to have poorer particle and magnetic confinement than expected from simple theory. The purpose of this study is to examine the role of plasma density in the decay of spheromaks produced in the Maryland Spheromak experiment. Density measurements are made with an interferometer and Langmuir probe, and results are correlated with those of other plasma diagnostics to understand the sources of plasma, the spheromak formation effects on the density, and the magnitude of particle loss during the spheromak decay. A power and particle balance computer model is constructed and applied to the spheromaks studied in order to assess the impact of high density and particle loss rate on the spheromak decay. The observations and model indicate that the decay of the spheromaks is at present dominated by impurity radiation loss. The model also predicts that high density and short particle confinement time play a critical role in the spheromak power balance when the impurity levels are reduced

Transient Transport Experiments in the CDX-U Spherical Torus

International Nuclear Information System (INIS)

T. Munsat; P.C. Efthimion; B. Jones; R. Kaita; R. Majeski; D. Stutman; G. Taylor

2001-01-01

Electron transport has been measured in the Current Drive Experiment-Upgrade (CDX-U) using two separate perturbative techniques. Gas modulation at the plasma edge was used to introduce cold-pulses which propagate towards the plasma center, providing time-of-flight information leading to a determination of chi(subscript e) as a function of radius. Sawteeth at the q=1 radius (r/a ∼ 0.15) induced heat-pulses which propagated outward towards the plasma edge, providing a complementary time-of-flight based chi(subscript e) profile measurement. This work represents the first localized measurement of chi(subscript e) in a spherical torus. It is found that chi(subscript e) = 1-2 meters squared per second in the plasma core (r/a < 1/3), increasing by an order of magnitude or more outside of this region. Furthermore, the chi(subscript e) profile exhibits a sharp transition near r/a = 1/3. Spectral and profile analyses of the soft X-rays, scanning interferometer, and edge probe data show no evidence of a significant magnetic island causing the high chi(subscript e) region

Current drive by spheromak injection into a tokamak

International Nuclear Information System (INIS)

Brown, M.R.; Bellan, P.M.

1990-01-01

The authors report the first observation of current drive by spheromak injection into a tokamak due to the process of helicity injection. Current drive is observed in Caltech's ENCORE tokamak (30% increase, ΔI > 1 kA) only when both the tokamak and injected spheromak have the same sign of helicity (where helicity is defined as positive if current flows parallel to magnetic field lines and negative if anti-parallel). The initial increase (decrease) in current is accompanied by a sharp decrease (increase) in loop voltage and the increase in tokamak helicity is consistent with the helicity content of the injected spheromak. In addition, the injection of the spheromak raises the tokamak central density by a factor of six. The introduction of cold spheromak plasma causes sudden cooling of the tokamak discharge from 12 eV to 4 eV which results in a gradual decline in tokamak plasma current by a factor of three. In a second experiment, the authors inject spheromaks into the magnetized toroidal vacuum vessel (with no tokamak plasma). An m = 1 magnetic structure forms in the vessel after the spheromak undergoes a double tilt; once in the cylindrical entrance between gun and tokamak, then again in the tokamak vessel. A horizontal shift of the spheromak equilibrium is observed in the direction opposite that of the static toroidal field. In the absence of net toroidal flux, the structure develops a helical pitch as predicted by theory. Experiments with a number of refractory metal coatings have shown that tungsten and chrome coatings provide some improvement in spheromak parameters. They have also designed and will soon construct a larger, higher current spheromak gun with a new accelerator section for injection experiments on the Phaedrus-T tokamak

Magnetic Reconnection Results on the Swarthmore Spheromak Experiment

Science.gov (United States)

Kornack, T. W.; Sollins, P. K.; Brown, M. R.

1997-11-01

Linear and 2D arrays of magnetic probes are used to study magnetic reconnection in the Swarthmore Spheromak Experiment (SSX). Opposing coaxial plasma guns form two identical spheromaks into adjacent 0.5 m diameter copper flux conservers. The flux conservers have symmetrical openings that allow the spheromaks to merge in a controlled manner. The stable equilibrium of the spheromaks provides a reservoir of magnetic flux for reconnection experiments. Currently, the magnetic configuration of the spheromaks allows the study of counter-helicity reconnection. Preliminary analysis will be presented and may include 2D B field movies of the reconnection region, measurement of the reconnection rate and comparison to the Sweet-Parker and standard Petschek models.

Spheromak Impedance and Current Amplification

International Nuclear Information System (INIS)

Fowler, T K; Hua, D D; Stallard, B W

2002-01-01

It is shown that high current amplification can be achieved only by injecting helicity on the timescale for reconnection, τ REC , which determines the effective impedance of the spheromak. An approximate equation for current amplification is: dI TOR 2 /dt ∼ I 2 /τ REC - I TOR 2 /τ closed where I is the gun current, I TOR is the spheromak toroidal current and τ CLOSED is the ohmic decay time of the spheromak. Achieving high current amplification, I TOR >> I, requires τ REC CLOSED . For resistive reconnection, this requires reconnection in a cold zone feeding helicity into a hot zone. Here we propose an impedance model based on these ideas in a form that can be implemented in the Corsica-based helicity transport code. The most important feature of the model is the possibility that τ REC actually increases as the spheromak temperature increases, perhaps accounting for the ''voltage sag'' observed in some experiments, and a tendency toward a constant ratio of field to current, B ∝ I, or I TOR ∼ I. Program implications are discussed

Sustained spheromak experiments in CTX

International Nuclear Information System (INIS)

Jarboe, T.R.; Barnes, C.W.; Henins, I.; Hoida, H.W.; Linford, R.K.; Sherwood, A.R.

1983-01-01

So far, spheromaks can be sustained as long as the source is injecting helicity. When the injection stops the configuration decays. Spheromks have been sustained for more than 1 ms with total lifetimes of more than 2 ms. The physical properties of the sustained spheromak are under investigation in this paper. Preliminary data indicate that (B) approx. = 2 kG, n approx. = 2 x 10 14 -cm -3 and T /sub e/ approx. = 20-30 eV. An helicity decay rate is determined from the ratio of an estimate of the helicity content of the spheromak and the rate of helicity flow from the source. In the coaxial source geometry a constant value of poloidal flux /PHI/ /sub p/ is placed inside the center electrode. By applying a voltage V between the two electrodes toroidal flux is injected (/PHI/ /sub t/ =V) which links the poloidal flux. The rate of helicity injection is then 2V/PHI/ /sub p/ . The helicity content of the spheromak is estimated by measuring the fields at one point and using the model described above to calculate the profiles. The result is that /TAU/ /sub Hel/ approx. = 200 us. This value is about the same as the /TAU/ /sub B/ 2 of a decaying spheromak with similar parameters. These results indicate that helicity injection is possible and that a large fraction (30-100%) of the injected helicity is absorbed

Stellarmak a hybrid stellarator: Spheromak

International Nuclear Information System (INIS)

Hartman, C.W.

1980-01-01

This paper discusses hybridization of modified Stellarator-like transform windings (T-windings) with a Spheromak or Field-Reversed-Mirror configuration. This configuration, Stellarmak, retains the important topological advantage of the Spheromak or FRM of having no plasma linking conductors or blankets. The T-windings provide rotational transformation in toroidal angle of the outer poloidal field lines, in effect creating a reversed B/sub Toroidal/ Spheromak or adding average B/sub T/ to the FRM producing higher shear, increased limiting β, and possibly greater stability to kinks and tilt. The presence of field ripple in the toroidal direction may be sufficient to inhibit cancellation of directed ion current by electron drag to allow steady state operation with the toroidal as well as poloidal current maintained by neutral beams

Spheromak tilting and its stability control

International Nuclear Information System (INIS)

Hayashi, T.; Sato, T.

1983-01-01

Spheromak tilting instability was studied. A numerical technique to create a rather arbitrarily-shaped spheromak like the one with a flux hole was investigated. The dynamics governing the tilting instability, namely, the influence of the magnetic index, the toroidal current (q-profile) and the resistivity upon the tilting growth rate, and the roles of magnetc reconnection upon the nonlinear development were studied. The best way to control the tilting instability was invented. The stabilizing effects of the vertical wall, the isolated conducting cylindrical belt, and the horizontal wall were studied. Central pole stabilization was also investigated. The influence of the wall condition, namely, whether the wall acted as a flux conserver in the spheromak creation stage or not is discussed. The present study has shown that the three- dimensional simulation is indeed useful and practical in not only studying the underlying physics but also finding a stabilization technique of spheromaks. (Kato, T.)

Development of the STPX Spheromak System

Science.gov (United States)

Williams, R. L.; Clark, J.; Weatherford, C. A.

2015-11-01

The progress made in starting up the STPX Spheromak system, which is now installed at the Florida A&M University, is reviewed. Experimental, computational and theoretical activities are underway. The control system for firing the magnetized coaxial plasma gun and for collecting data from the diagnostic probes, based on LabView, is being tested and adapted. Preliminary results of testing the installed magnetic field probes, Langmuir triple probes, cylindrical ion probes, and optical diagnostics will be discussed. Progress in modeling this spheromak using simulation codes, such as NIMROD, will be discussed. Progress in investigating the use of algebraic topology to describe this spheromak will be reported.

The Spheromak path to fusion energy

International Nuclear Information System (INIS)

Hooper, E.B.; Barnes, C.W.; Bellan, P.M.

1998-01-01

The spheromak is a simple and robust magnetofluid configuration with several attractive reactor attributes including compact geometry, no material center post, high engineering β, and sustained steady state operation through helicity injection. Spheromak physics was extensively studied in the US program and abroad (especially Japan) in the 1980' s with work continuing into the 1990s in Japan and the UK. Scientific results included demonstration of self-organization at constant helicity, control of the tilt and shift modes by shaped flux conservers, elucidation of the role of magnetic reconnection in the magnetic dynamo, and sustainment of a spheromak by helicity injection. Several groups attained electron temperatures above 100 eV in decaying plasmas, with CTX reaching 400 eV. This experiment had high magnetic field (>l T on the edge and ∼ 3 T near the symmetry axis) and good confinement. More recently, analysis of CTX found the energy confinement in the plasma core to be consistent with Rechester-Rosenbluth transport in a fluctuating magnetic field, potentially scaling to good confinement at higher electron temperatures. The SPHEX group developed an understanding of the dynamo in sustained spheromaks but in a relatively cold device. These and other physics results provide a foundation for a new ''concept exploration'' experiment to study the physics of a hot, sustained spheromak. If successful, this work leads to a next generation, proof-of-principle program. The new SSPX experiment will address the physics of a large-scale sustained spheromak in a national laboratory (LLNL) setting. The key issue in near term spheromak research will be to explore the possibly deleterious effects of sustainment on confinement. Other important issues include exploring the β scaling of confinement, scaling with Lundquist number S, and determining the need for active current-profile control. Collaborators from universities and other national laboratories are contributing

Design of a spheromak compressor driven by high explosives

International Nuclear Information System (INIS)

Henins, I.; Fernandez, J.C.; Jarboe, T.R.; Marsh, S.P.; Marklin, G.J.; Mayo, R.M.; Wysocki, F.J.

1990-01-01

High energy density spheromaks can be used to accelerate a thin section of the flux conserver wall to high velocities. The energy density of a spheromak, formed by conventional helicity injection into a flux conserver, can be increased by reducing the flux conserver volume after the spheromak is formed. A method of accomplishing this is by imploding one wall of the flux conserver with high explosives. The authors have embarked on a program to demonstrate that a spheromak can be used as an energy transfer medium, and that a velocity gain over high-explosive driven plate velocities can be achieved. To do this, a plasma gun helicity source that will inject a spheromak with suitable initial energy density and lifetime is needed. Also, an implodable flux conserver that remains intact and clean during the implosion must be developed. The flux conserver problem is probably the more challenging one, because very little experimental work has been done in the past on explosively driven metal plates into a high vacuum, with sizes and travel distances appropriate for their application. There are two necessary practical requirements for an explosive compression of a flux conserver. The first is that the imploding wall does not rupture. The second is that gasses or other debri are not ejected which could penetrate and poison the spheromak plasma, and thus reduce the spheromak lifetime below what is necessary to carry out the spheromak compression and the subsequent acceleration of the flyer plate. The authors have designed and fabricated a plasma gun to be used for injecting the initial spheromak plasma into the collapsible flux conserver

CDX2 gene expression in acute lymphoblastic leukemia

International Nuclear Information System (INIS)

Arnaoaut, H.H.; Mokhtar, D.A.; Samy, R.M.; Omar, Sh.A.; Khames, S.A.

2014-01-01

CDX genes are classically known as regulators of axial elongation during early embryogenesis. An unsuspected role for CDX genes has been revealed during hematopoietic development. The CDX gene family member CDX2 belongs to the most frequent aberrantly expressed proto-oncogenes in human acute leukemias and is highly leukemogenic in experimental models. We used reversed transcriptase polymerase chain reaction (RT-PCR) to determine the expression level of CDX2 gene in 30 pediatric patients with acute lymphoblastic leukemia (ALL) at diagnosis and 30 healthy volunteers. ALL patients were followed up to detect minimal residual disease (MRD) on days 15 and 42 of induction. We found that CDX2 gene was expressed in 50% of patients and not expressed in controls. Associations between gene expression and different clinical and laboratory data of patients revealed no impact on different findings. With follow up, we could not confirm that CDX2 expression had a prognostic significance.

Scaling studies of spheromak formation and equilibrium

International Nuclear Information System (INIS)

Geddes, C.G.; Kornack, T.W.; Brown, M.R.

1998-01-01

Formation and equilibrium studies have been performed on the Swarthmore Spheromak Experiment (SSX). Spheromaks are formed with a magnetized coaxial plasma gun and equilibrium is established in both small (d small =0.16 m) and large (d large =3d small =0.50 m) copper flux conservers. Using magnetic probe arrays it has been verified that spheromak formation is governed solely by gun physics (in particular the ratio of gun current to flux, μ 0 I gun /Φ gun ) and is independent of the flux conserver dimensions. It has also been verified that equilibrium is well described by the force free condition ∇xB=λB (λ=constant), particularly early in decay. Departures from the force-free state are due to current profile effects described by a quadratic function λ=λ(ψ). Force-free SSX spheromaks will be merged to study magnetic reconnection in simple magnetofluid structures. copyright 1998 American Institute of Physics

Computational studies of ohmic heating in the spheromak

International Nuclear Information System (INIS)

Olson, R.E.

1983-01-01

Time-dependent computational simulations using both single-fluid O-D and two-fluid 1 1/2-D models are developed for and utilized in an investigation of the ohmic heating of a spheromak plasma. The plasma density and composition, the applied magnetic field strength, the plasma size, and the plasma current density profile are considered for their effects on the spheromak heating rate and maximum achievable temperature. The feasibility of ohmic ignition of a reactor-size spheromak plasma is also contemplated

Overview of the HIT-SI3 spheromak experiment

Science.gov (United States)

Hossack, A. C.; Jarboe, T. R.; Chandra, R. N.; Morgan, K. D.; Sutherland, D. A.; Everson, C. J.; Penna, J. M.; Nelson, B. A.

2017-10-01

The HIT-SI and HIT-SI3 spheromak experiments (a = 23 cm) study efficient, steady-state current drive for magnetic confinement plasmas using a novel method which is ideal for low aspect ratio, toroidal geometries. Sustained spheromaks show coherent, imposed plasma motion and low plasma-generated mode activity, indicating stability. Analysis of surface magnetic fields in HIT-SI indicates large n = 0 and 1 mode amplitudes and little energy in higher modes. Within measurement uncertainties all the n = 1 energy is imposed by the injectors, rather than being plasma-generated. The fluctuating field imposed by the injectors is sufficient to sustain the toroidal current through dynamo action whereas the plasma-generated field is not (Hossack et al., Phys. Plasmas, 2017). Ion Doppler spectroscopy shows coherent, imposed plasma motion inside r 10 cm in HIT-SI and a smaller volume of coherent motion in HIT-SI3. Coherent motion indicates the spheromak is stable and a lack of plasma-generated n = 1 energy indicates the maximum q is maintained below 1 for stability during sustainment. In HIT-SI3, the imposed mode structure is varied to test the plasma response (Hossack et al., Nucl. Fusion, 2017). Imposing n = 2, n = 3, or large, rotating n = 1 perturbations is correlated with transient plasma-generated activity. Work supported by the U.S. Department of Energy, Office of Science, Office of Fusion Energy Sciences, under Award Number DE-FG02-96ER54361.

Final Report Sustained Spheromak Physics Project FY 1997 - FY 1999

International Nuclear Information System (INIS)

Hooper, E.B.; Hill, D.N.

2000-01-01

This is the final report on the LDRD SI-funded Sustained Spheromak Physics Project for the years FY1997-FY1999, during which the SSPX spheromak was designed, built, and commissioned for operation at LLNL. The specific LDRD project covered in this report concerns the development, installation, and operation of specialized hardware and diagnostics for use on the SSPX facility in order to study energy confinement in a sustained spheromak plasma configuration. The USDOE Office of Fusion Energy Science funded the construction and routine operation of the SSPX facility. The main distinctive feature of the spheromak is that currents in the plasma itself produce the confining toroidal magnetic field, rather than external coils, which necessarily thread the vacuum vessel. There main objective of the Sustained Spheromak Physics Project was to test whether sufficient energy confinement could be maintained in a spheromak plasma sustained by DC helicity injection. Achieving central electron temperatures of several hundred eV would indicate this. In addition, we set out to determine how the energy confinement scales with T c and to relate the confinement time to the level of internal magnetic turbulence. Energy confinement and its scaling are the central technical issues for the spheromak as a fusion reactor concept. Pending the outcome of energy confinement studies now under way, the spheromak could be the basis for an attractive fusion reactor because of its compact size, simply-connected magnetic geometry, and potential for steady-state current drive

Magnetic helicity balance in the Sustained Spheromak Plasma Experiment

International Nuclear Information System (INIS)

Stallard, B.W.; Hooper, E.B.; Woodruff, S.; Bulmer, R.H.; Hill, D.N.; McLean, H.S.; Wood, R.D.

2003-01-01

The magnetic helicity balance between the helicity input injected by a magnetized coaxial gun, the rate-of-change in plasma helicity content, and helicity dissipation in electrode sheaths and Ohmic losses have been examined in the Sustained Spheromak Plasma Experiment (SSPX) [E. B. Hooper, L. D. Pearlstein, and R. H. Bulmer, Nucl. Fusion 39, 863 (1999)]. Helicity is treated as a flux function in the mean-field approximation, allowing separation of helicity drive and losses between closed and open field volumes. For nearly sustained spheromak plasmas with low fluctuations, helicity balance analysis implies a decreasing transport of helicity from the gun input into the spheromak core at higher spheromak electron temperature. Long pulse discharges with continuously increasing helicity and larger fluctuations show higher helicity coupling from the edge to the spheromak core. The magnitude of the sheath voltage drop, inferred from cathode heating and a current threshold dependence of the gun voltage, shows that sheath losses are important and reduce the helicity injection efficiency in SSPX

Sustained Spheromak Physics Experiment, SSPX

International Nuclear Information System (INIS)

Hooper, E.B.

1997-01-01

The Sustained Spheromak Physics Experiment is proposed for experimental studies of spheromak confinement issues in a controlled way: in steady state relative to the confinement timescale and at low collisionality. Experiments in a flux - conserver will provide data on transport in the presence of resistive modes in shear-stabilized systems and establish operating regimes which pave the way for true steady-state experiments with the equilibrium field supplied by external coils. The proposal is based on analysis of past experiments, including the achievement of T e = 400 eV in a decaying spheromak in CTX. Electrostatic helicity injection from a coaxial ''''gun'''' into a shaped flux conserver will form and sustain the plasma for several milliseconds. The flux conserver minimizes fluxline intersection with the walls and provides MHD stability. Improvements from previous experiments include modem wall conditioning (especially boronization), a divertor for density and impurity control, and a bias magnetic flux for configurational flexibility. The bias flux will provide innovative experimental opportunities, including testing helicity drive on the large-radius plasma boundary. Diagnostics include Thomson scattering for T e measurements and ultra-short pulse reflectrometry to measure density and magnetic field profiles and turbulence. We expect to operate at T e of several hundred eV, allowing improved understanding of energy and current transport due to resistive MHD turbulence during sustained operation. This will provide an exciting advance in spheromak physics and a firm basis for future experiments in the fusion regime

Investigations into the relationship between spheromak, solar, and astrophysical plasmas

International Nuclear Information System (INIS)

Bellan, P.M.; Hsu, S.C.; Hansen, J.F.; Tokman, M.; Pracko, S.E.; Romero-Talamas, C.A.

2003-01-01

Spheromaks offer the potential for a simple, low cost fusion reactor and involve physics similar to certain solar and astrophysical phenomena. A program to improve understanding of spheromaks by exploiting this relationship is underway using (i) a planar spheromak gun and (ii) a solar prominence simulator. These devices differ in symmetry but both involve spheromak technology whereby high-voltage is applied across electrodes linking a bias magnetic flux created by external coils. The planar spheromak gun consists of a co-planar disk and annulus linked by a poloidal bias field. Application of high voltage across the gap between disk and annulus drives a current along the bias field. If the current to flux ratio exceeds the inverse of the characteristic linear dimension, a spheromak is ejected. A distinct kink forms just below the ejection threshold. The solar simulation gun consists of two adjacent electromagnets which generate a 'horse-shoe' arched bias field. A current is driven along this arched field by a capacitor bank. The current channel first undergoes pinching, then writhes, and finally bulges outwards due to the hoop force. (author)

Re-examination of spheromak experiments and opportunities

International Nuclear Information System (INIS)

Hooper, B.E.; Hammer, J.H.; Barnes, C.W.; Fernandez, J.C.; Wysocki, F.J.

1996-01-01

The results of spheromak experiments are reexamined in light of the hypothesis that the core energy confinement is considerably better than the global confinement and that it extrapolates favorably with magnetic Reynolds number S. The data in decaying spheromaks are found to be consistent with the hypothesis and with magnetic fluctuations scaling as S -1/2 and determining the electron thermal conductivity. No conclusion is drawn from the data for sustained spheromaks, indicating the importance of a new experiment to determine core energy confinement while helicity is injected. The characteristics of such an experiment are discussed, including the importance of using modern vacuum and wall-conditioning techniques and of minimizing magnetic field errors. 44 refs., 7 figs., 1 tab

Studies of conceptual spheromak fusion reactors

International Nuclear Information System (INIS)

Katsurai, M.; Yamada, M.

1982-01-01

Preliminary design studies are carried out for a spheromak fusion reactor. Simplified circuit theory is applied to obtain the characteristic relations among various parameters of the spheromak configuration for an aspect ratio of A >or approx. 1.6. These relations are used to calculate the parameters for the conceptual designs of three types of fusion reactor: (1) the DT reactor with two-component-type operation, (2) the ignited DT reactor, and (3) the ignited catalysed-type DD reactor. With a total wall loading of approx. 4 MW.m -2 , it is found that edge magnetic fields of only approx. 4 T (DT) and approx. 9 T (Cat. DD) are required for ignited reactors of 1 m plasma (minor) radius with output powers in the gigawatt range. An assessment of various schemes of generation, compression and translation of spheromak plasmas is presented. (author)

Methylation-Dependent Activation of CDX1 through NF-κB

Science.gov (United States)

Rau, Tilman T.; Rogler, Anja; Frischauf, Myrjam; Jung, Andreas; Konturek, Peter C.; Dimmler, Arno; Faller, Gerhard; Sehnert, Bettina; El-Rifai, Wael; Hartmann, Arndt; Voll, Reinhard E.; Schneider-Stock, Regine

2013-01-01

The caudal homeobox factor 1 (CDX1) is an essential transcription factor for intestinal differentiation. Its aberrant expression in intestinal metaplasia of the upper gastrointestinal tract is a hallmark within the gastritis-metaplasia-carcinoma sequence. CDX1 expression is influenced by certain pathways, such as Wnt, Ras, or NF-κB signaling; however, these pathways alone cannot explain the transient expression of CDX1 in intestinal metaplasia or the molecular inactivation mechanism of its loss in cases of advanced gastric cancer. In this study, we investigated the epigenetic inactivation of CDX1 by promoter methylation, as well as the functional link of CDX1 promoter methylation to the inflammatory NF-κB signaling pathway. We identified methylation-dependent NF-κB binding to the CDX1 promoter and quantified it using competitive electrophoretic mobility shift assays and chromatin immunoprecipitation. A methylated CDX1 promoter was associated with closed chromatin structure, reduced NF-κB binding, and transcriptional silencing. Along the gastritis-metaplasia-carcinoma sequence, we observed a biphasic pattern of tumor necrosis factor-α (TNF-α) protein expression and an inverse biphasic pattern of CDX1 promoter methylation; both are highly consistent with CDX1 protein expression. The stages of hyper-, hypo-, and hyper-methylation patterns of the CDX1 promoter were inversely correlated with the NF-κB signaling activity along this sequence. In conclusion, these functionally interacting events drive CDX1 expression and contribute to intestinal metaplasia, epithelial dedifferentiation, and carcinogenesis in the human stomach. PMID:22749770

Steady-state operation of spheromaks by inductive techniques

International Nuclear Information System (INIS)

Janos, A.

1984-04-01

A method to maintain a steady-state spheromak configuration inductively using the S-1 Spheromak device is described. The S-1 Spheromak formation apparatus can be utilized to inject magnetic helicity continuously (C.W., not pulsed or D.C.) into the spheromak configuration after equilibrium is achieved in the linked mode of operation. Oscillation of both poloidal- and toroidal-field currents in the flux core (psi-phi Pumping), with proper phasing, injects a net time-averaged helicity into the plasma. Steady-state maintenance relies on flux conversion, which has been earlier identified. Relevant experimental data from the operation of S-1 are described. Helicity flow has been measured and the proposed injection scheme simulated. In a reasonable time practical voltages and frequencies can inject an amount of helicity comparable to that in the initial plasma. Plasma currents can be maintained or increased. This pumping technique is similar to F-THETA Pumping of a Reversed-Field-Pinch but is applied to this inverse-pinch formation

Spheromak experiment using separate guns for formation and sustainment

International Nuclear Information System (INIS)

Brown, M.R.; Martin, A.

1996-01-01

An experiment is described that incorporates the use of separate magnetized plasma guns for formation and sustainment of a spheromak. It is shown that energy coupling efficiency approaches unity if the gun and spheromak are of comparable size. A large gun should be able to operate at lower current and therefore lower voltage. In addition, it is expected that a gun matched to the size of the spheromak will cause less perturbation to the equilibrium. It is proposed to use a smaller gun for spheromak formation and a large, efficient gun for sustainment. The theoretical basis for the experiment is developed, and the details of the experiment are described. A prediction of the equilibrium magnetic flux surfaces using the EFIT code is presented. 28 refs., 3 figs., 1 tab

Advanced spheromak fusion reactor

International Nuclear Information System (INIS)

Fowler, T.K.

1996-01-01

The spheromak has no toroidal magnetic field coils or other structure along its geometric axis, and is thus more attractive than the leading magnetic fusion reactor concept, the tokamak. As a consequence of this and other attributes, the spheromak reactor may be compact and produce a power density sufficiently high to warrant consideration of a liquid 'blanket' that breeds tritium, converts neutron kinetic energy to heat, and protects the reactor vessel from severe neutron damage. However, the physics is more complex, so that considerable research is required to learn how to achieve the reactor potential. Critical physics problems and possible ways of solving them are described. The opportunities and issues associated with a possible liquid wall are considered to direct future research

Spheromak formation studies in SSPX

International Nuclear Information System (INIS)

Hill, D.N.; Bulmer, R.H.; Cohen, B.L.; Hooper, E.B.; LoDestro, L.L.; Mattor, N.; McLean, H.S.; Moller, J.; Pearlstein, L.D.; Ryutov, D.D.; Stallard, B.W.; Wood, R.D.; Woodruff, S.; Holcomb, C.T.; Jarboe, T.; Sovinec, C.R.; Wang, Z.; Wurden, G.

2000-01-01

We present results from the Sustained Spheromak Physics Experiment (SSPX) at LLNL, which has been built to study energy confinement in spheromak plasmas sustained for up to 2 ms by coaxial DC helicity injection. Peak toroidal currents as high as 600kA have been obtained in the 1m dia. (0.23m minor radius) device using injection currents between 200-400kA; these currents generate edge poloidal fields in the range of 0.2-0.4T. The internal field and current profiles are inferred from edge field measurements using the CORSICA code. Density and impurity control is obtained using baking, glow discharge cleansing, and titanium gettering, after which long plasma decay times (τ (ge) 1.5ms) are observed and impurity radiation losses are reduced from ∼50% to e (0)∼120eV and β e ∼7%. Edge field measurements show the presence of n=1 modes during the formation phase, as has been observed in other spheromaks. This mode dies away during sustainment and decay so that edge fluctuation levels as low as 1% have been measured. These results are compared with numerical simulations using the NIMROD code

Cdx function is required for maintenance of intestinal identity in the adult.

Science.gov (United States)

Hryniuk, Alexa; Grainger, Stephanie; Savory, Joanne G A; Lohnes, David

2012-03-15

The homeodomain transcription factors Cdx1 and Cdx2 are expressed in the intestinal epithelium from early development, with expression persisting throughout the life of the animal. While our understanding of the function of Cdx members in intestinal development has advanced significantly, their roles in the adult intestine is relatively poorly understood. In the present study, we found that ablation of Cdx2 in the adult small intestine severely impacted villus morphology, proliferation and intestinal gene expression patterns, resulting in the demise of the animal. Long-term loss of Cdx2 in a chimeric model resulted in loss of all differentiated intestinal cell types and partial conversion of the mucosa to a gastric-like epithelium. Concomitant loss of Cdx1 did not exacerbate any of these phenotypes. Loss of Cdx2 in the colon was associated with a shift to a cecum-like epithelial morphology and gain of cecum-associated genes which was more pronounced with subsequent loss of Cdx1. These findings suggest that Cdx2 is essential for differentiation of the small intestinal epithelium, and that both Cdx1 and Cdx2 contribute to homeostasis of the colon. Copyright © 2012 Elsevier Inc. All rights reserved.

A new diagnostic for spheromaks

International Nuclear Information System (INIS)

Boyd, D.A.

1986-01-01

Electron cyclotron emission from a spheromak plasma may be able to provide information about the confining magnetic field of the system. Emission generated in the extraordinary mode wit hits electric vector perpendicular to the local magnetic field at sufficiently high frequency will propagate out of the plasma while retaining the original orientation if its electric vector. Thus, a measurement of the orientation of the emergent electric vector and the emission frequency will allow one to deduce the orientation and strength of the magnetic field at the radiation source. In this paper, simple models of the Maryland spheromak are used to examine the practicality of such a diagnostic

??????????? ????????? ???????????? ???????????? NH4X (?=??,?1) ??? ??????????? CdxHgi-xTe ??????? ???????? ???????????? ???????

OpenAIRE

??????, ?. ?.; ?????????, ?. ?.; ???????, ?. ?.; ?????????, ?. ?.; ?????????, ?. ?.

2004-01-01

?? ?????? ??????????? ?????????? ???????????? ?????? ??????? ???? ??????? CdxHgi_xTe-Hg-NH4Br ??? ??????? ?????? Hg ? ????????? ?????????? 560-860? ? ??????????? ?????? ?? = 103-=-105 ?? ????????? ????????, ??? ??????? ???????? ????? ? ??????????????? ??????, ????? ? ?????? - CdBr2, Hg, ??2. ??? ????????? ??????? ??????? ???????????? CdxHgi_xTe ??????? ? = 0.2; 0.3; 0.4 ?? ????????? ??? ??? ? ??? ?????????? ??????? ???????? ??????? (??? ?????? ?????? ????? ? ???????) ????????? ??????????? ???...

All plasma spheromak: the plasmak

International Nuclear Information System (INIS)

Koloc, P.; Ogden, J.

1981-01-01

There has been an evolutionary pattern established in magnetic fusion concepts. The flow in ideas follows three directions. By extrapolating this evolutionary movement, we have anticipated the concept called Spheromak and have predicted the omega of this evolution which is called PLASMAK, or Plasma Spheromak. The evolutionary directions are from open systems to closed systems, from zero or low dimensional compression schemes to three dimensional compression, and finally from plasma configurations without any self confining currents to a plasma configuration which is completely self confined except for the mechanical pressure necessary to maintain the verticle field and hoop stress. Nevertheless, the plasma is imprisoned by heavy poloidal coils and a vacuum wall

Field and current amplification in the SSPX spheromak

International Nuclear Information System (INIS)

Hill, D.N. . hilld@llnl.gov; Bulmer, R.H.; Cohen, B.I.

2003-01-01

Results are presented from experiments relating to magnetic field generation and current amplification in the SSPX spheromak. The SSPX spheromak plasma is driven by DC coaxial helicity injection using a 2MJ capacitor bank. Peak toroidal plasma currents of up to 0.7MA and peak edge poloidal fields of 0.3T are produced; lower current discharges can be sustained up to 3.5msec. When edge magnetic fluctuations are reduced below 1% by driving the plasma near threshold, it is possible to produce plasmas with Te > 150eV, e >∼4% and core χ e ∼30m 2 /s. Helicity balance for these plasmas suggests that sheath dissipation can be significant, pointing to the importance of maximizing the voltage on the coaxial injector. For most operational modes we find a stiff relationship between peak spheromak field and injector current, and little correlation with plasma temperature, which suggests that other processes than ohmic dissipation may limit field amplification. However, slowing spheromak buildup by limiting the initial current pulse increases the ratio of toroidal current to injected current and points to new operating regimes with more favorable current amplification. (author)

Stability of force-free spheromak plasma in spheroidal flux conserver

International Nuclear Information System (INIS)

Kaneko, Shobu; Tsutsui, Hiroaki

1988-01-01

The Woltjer-Taylor method is applied to spheromak plasmas in spheroidal flux conservers. As models of the flux conserver, both oblate and prolate spheroidal vessels with a center conductor are used. The plasma is not assumed to be nearly spherical, and the Rayleigh-Ritz method and the finite element method are used to evaluate the eigenvalues. The oblate spheromak is shown to be stable irrespective of the shape of the flux conserver. Though the prolate spheromak is unstable if there is no center conductor, it can be stable if the center conductor is installed. (author)

Simulation of Spheromak Evolution and Energy Confinement

International Nuclear Information System (INIS)

Cohen, B; Hooper, E; Cohen, R; Hill, D; McLean, H; Wood, R; Woodruff, S; Sovinec, C; Cone, G

2004-01-01

Simulation results are presented that illustrate the formation and decay of a spheromak plasma driven by a coaxial electrostatic plasma gun, and that model the energy confinement of the plasma. The physics of magnetic reconnection during spheromak formation is also illuminated. The simulations are performed with the three-dimensional, time-dependent, resistive magnetohydrodynamic NIMROD code. The simulation results are compared to data from the SSPX spheromak experiment at the Lawrence Livermore National Laboratory. The simulation results are tracking the experiment with increasing fidelity (e.g., improved agreement with measurements of the magnetic field, fluctuation amplitudes, and electron temperature) as the simulation has been improved in its representations of the geometry of the experiment (plasma gun and flux conserver), the magnetic bias coils, and the detailed time dependence of the current source driving the plasma gun, and uses realistic parameters. The simulations are providing a better understanding of the dominant physics in SSPX, including when the flux surfaces close and the mechanisms limiting the efficiency of electrostatic drive

Increased particle confinement with the use of external dc bias field in the CTX spheromak

International Nuclear Information System (INIS)

Barnes, C.W.; Hoida, H.W.; Henins, I.; Fernandez, J.C.; Jarboe, T.R.; Marklin, G.J.

1985-01-01

Spheromaks are formed in a mesh flux conserver in the presence of an external dc bias field. The spheromaks remain stable to tilt instabilities with ratios of bias-to-spheromak flux of up to 47 +- 7%. Normally applied bias flux puts the spheromak separatrix inside the metal mesh and improves the particle confinement

Studies on spheromak plasma production by external-flux-core method, (2)

International Nuclear Information System (INIS)

Arata, Masanori; Katsurai, Makoto

1984-01-01

The spheromak technique, one of magnetic plasma containment techniques, has such arrangement of magnetic fields that the toroidal magnetic field is produced by the poloidal current flowing in plasma, and the poloidal magnetic field is produced by the toroidal current in plasma and the current in external coils. The authors proposed external flux core method as the technique of plasma formation by this spheromak method, in which the toroidal magnetic field is injected by the discharge using electrodes, whereas the poloidal magnetic field is injected by induction discharge without electrode. Its fundamental action was analyzed by computer simulation and confirmed by experiment. In this study, the behavior of the spheromak plasma produced was investigated in detail and summarized. The contents were the measurement of the spheromak configuration produced and the estimation of plasma parameters. The experimental setup, the principle of action, and the experimental results of magnetic field distribution obtained by a magnetic probe, ion current measured by an electrostatic probe, electron temperature by spectroscopic measurement and the behavior of spheromak plasma observed with an image converter camera are reported. (Kako, I.)

CDX1 is an important molecular mediator of Barrett's metaplasia

DEFF Research Database (Denmark)

Wong, N A C S; Wilding, J; Bartlett, S

2005-01-01

and the inflammatory cytokines TNF-alpha and IL-1beta were all found to increase CDX1 mRNA expression in vitro. These effects were primarily mediated by NF-kappaB signaling but only occurred when the CDX1 promoter was unmethylated or partially methylated. The data suggest that CDX1 is a key molecule linking...

Helicobacter pyloria ssociation with expression of cdx2 in intestinal metaplasia

International Nuclear Information System (INIS)

Malik, T.H.; Hong, X.

2017-01-01

To assess whether helicobacter pylori was associated with CDX2 expression in intestinal metaplasia, atrophic gastritis, dysplasia and gastric cancer. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pathology, The First Hospital of Jilin University, Changchun, China, from August 2016 to January 2017. Methodology: CDX2 expression was evaluated in 62 gastric antral biopsies; including 32 cases of intestinal metaplasia (IM) and 10 cases each of atrophic gastritis (AG), dysplasia and gastric cancer. Hematoxylin and Eosin staining was used to detect H.pyloriand immunohistochemistry was performed to observe CDX2 in the samples. Results: Of the 62 patients inducted in the study, CDX2 expression was observed in 53 (85.5%). Mean age of these patients was 59 years (s.d.:11.3; range: 38-87) and included 32 males (60.38%) and 21 females (39.62%). However, age and gender were not found to be significantly associated with expression of CDX2 (p >0.05). CDX2 was very frequently expressed in individuals with IM (90.6%). Most of the patients with IM were males (17/29) as compared to females (12/29). However, the difference was not statistically significant (p=0.568). Only 4 out of 29 IM CDX2 positive specimens tested positive for H.pylori(p=1.0). Conclusion: CDX2 is highly expressed along the atrophic gastritis-metaplasia-dysplasia-cancer sequential. Though CDX2 expression is quite dominant in IM, but its expression is not associated with H.pylori infection. (author)

Review of spheromak research

International Nuclear Information System (INIS)

Jarboe, T.R.

1994-01-01

Spheromak research from 1979 to the present is reviewed including over 160 references. Emphasis is on understanding and interpretation of results. In addition to summarizing results some new interpretations are presented. An introduction and brief history is followed by a discussion of generalized helicity and its time derivative. Formation and sustainment are discussed including five different methods, flux core, θ-pinch z-pinch, coaxial source, conical θ-pinch, and kinked z-pinch. All methods are helicity injections. Steady-state methods and rules for designing spheromak experiments are covered, followed by equilibrium and stability. Methods of stabilizing the tilt and shift modes are discussed as well as their impact on the reactor designs. Current-driven and pressure-driven instabilities as well as relaxation in general are covered. Energy confinement is discussed in terms of helicity decay time and βs limits. The confinement in high and low open-flux geometries are compared and the reactor implications discussed. (author)

Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1

DEFF Research Database (Denmark)

Chan, Carol W M; Wong, Newton A; Liu, Ying

2009-01-01

colorectal cancer cell lines. Deletion and mutation analysis of the KRT20 promoter showed that the minimum regulatory region for the control of KRT20 expression by CDX1 is within 246 bp upstream of the KRT20 transcription start site. ChIP analysis confirmed that CDX1 binds to the predicted CDX elements...... in this region of the KRT20 promoter in vivo. In addition, immunohistochemistry showed expression of CDX1 parallels that of KRT20 in the normal crypt, which further supports their close relationship. In summary, our observations strongly imply that KRT20 is directly regulated by CDX1, and therefore suggest...... a role for CDX1 in maintaining differentiation in intestinal epithelial cells. Because a key feature of the development of a cancer is an unbalanced program of proliferation and differentiation, dysregulation of CDX1 may be an advantage for the development of a colorectal carcinoma. This could, therefore...

Ohmic heating of a spheromak to 100 eV

Energy Technology Data Exchange (ETDEWEB)

Jarboe, T.R.; Barnes, C.W.; Henins, I.; Hoida, H.W.; Knox, S.O.; Linford, R.K.; Sherwood, A.R.

1984-01-01

The first spheromaks with Thomson-scattering-measured electron temperatures of over 100 eV are described. The spheromak is generated by a magnetized coaxial plasma source in a background gas of 30 mTorr of H/sub 2/, and it is stably confined in an oblate 80 cm diam copper mesh flux conserver. The open mesh design allows rapid impurity transport out of the spheromak. The peak temperature, measured using multipoint Thomson scattering, is observed to rise from approximately 25 eV to over 100 eV in about 0.2 msec due to Ohmic heating from the decaying magnetic fields. Density (approx.5 x 10/sup 13/ cm/sup -3/) and magnetic fields (approximately 2 kG) are measured using interferometry and magnetic probes.

Ohmic heating of a spheromak to 100 eV

International Nuclear Information System (INIS)

Jarboe, T.R.; Barnes, C.W.; Henins, I.; Hoida, H.W.; Knox, S.O.; Linford, R.K.; Sherwood, A.R.

1984-01-01

The first spheromaks with Thomson-scattering-measured electron temperatures of over 100 eV are described. The spheromak is generated by a magnetized coaxial plasma source in a background gas of 30 mTorr of H 2 , and it is stably confined in an oblate 80 cm diam copper mesh flux conserver. The open mesh design allows rapid impurity transport out of the spheromak. The peak temperature, measured using multipoint Thomson scattering, is observed to rise from approximately 25 eV to over 100 eV in about 0.2 msec due to Ohmic heating from the decaying magnetic fields. Density (approx.5 x 10 13 cm -3 ) and magnetic fields (approximately 2 kG) are measured using interferometry and magnetic probes

Cdx2 modulates proliferation in normal human intestinal epithelial crypt cells

International Nuclear Information System (INIS)

Escaffit, Fabrice; Pare, Frederic; Gauthier, Remy; Rivard, Nathalie; Boudreau, Francois; Beaulieu, Jean-Francois

2006-01-01

The homeobox gene Cdx2 is involved in the regulation of the expression of intestine specific markers such as sucrase-isomaltase and lactase-phlorizin hydrolase. Previous studies performed with immortalized or transformed intestinal cell lines have provided evidence that Cdx2 can promote morphological and functional differentiation in these experimental models. However, no data exist concerning the implication of this factor in normal human intestinal cell physiology. In the present work, we have investigated the role of Cdx2 in normal human intestinal epithelial crypt (HIEC) cells that lack this transcription factor. The establishment of HIEC cells expressing Cdx2 in an inducible manner shows that forced expression of Cdx2 significantly alters the proliferation of intestinal crypt cells and stimulates dipeptidylpeptidase IV expression but is not sufficient to trigger intestinal terminal differentiation. These observations suggest that Cdx2 requires additional factors to activate the enterocyte differentiation program in normal undifferentiated cells

HOXB4 Gene Expression Is Regulated by CDX2 in Intestinal Epithelial Cells

DEFF Research Database (Denmark)

Jørgensen, Steffen; Coshun, Mehmet; Mikkelsen Homburg, Keld

2016-01-01

analysis and expression data from Caco2 cells also suggests a role for CDX2 in the regulation of HOXB4 gene expression in the intestinal epithelium. Thus, the aim of this study was to investigate whether HOXB4 gene expression is regulated by CDX2 in the intestinal epithelium. We demonstrated binding of CDX......The mammalian Caudal-related homeobox transcription factor 2 (CDX2) plays a key role in the homeobox regulatory network and is essential in regulating the expression of several homeobox (HOX) genes during embryonic development, particularly in the gut. Genome-wide CDX2 chromatin immunoprecipitation......2 to four different CDX2 binding sites in an enhancer region located upstream of the HOXB4 transcription start site. Mutations in the CDX2 binding sites reduced HOXB4 gene activity, and knock down of endogenous CDX2 expression by shRNA reduced HOXB4 gene expression. This is the first report...

Stellarator-Spheromak

International Nuclear Information System (INIS)

Moroz, P.E.

1997-03-01

A novel concept for magnetic plasma confinement, Stellarator-Spheromak (SSP), is proposed. Numerical analysis with the classical-stellarator-type outboard stellarator windings demonstrates a number of potential advantages of SSP for controlled nuclear fusion. Among the main ones are: simple and compact magnet coil configuration, absence of material structures (e.g. magnet coils or conducting walls) in the center of the torus, high rotational transform, and a possibility of MHD equilibria with very high β (pressure/magnetic pressure) of the confined plasma

Simulation of Spheromak Evolution and Energy Confinement

International Nuclear Information System (INIS)

Cohen, B.; Hooper, E.; Cohen, R.; Hill, D.; McLean, H.; Wood, R.; Woodruff, S.

2004-01-01

Simulation results are presented that illustrate the formation and decay of a spheromak plasma driven by a coaxial electrostatic plasma gun, and that model the energy confinement of the plasma. The physics of magnetic reconnection during spheromak formation is also illuminated. The simulations are performed with the three-dimensional, time-dependent, resistive magnetohydrodynamic NIMROD code. The dimensional, simulation results are compared to data from the SSPX spheromak experiment at the Lawrence Livermore National Laboratory. The simulation results are tracking the experiment with increasing fidelity (e.g., improved agreement with measurements of the magnetic field, fluctuation amplitudes, and electron temperature) as the simulation has been improved in its representations of the geometry of the experiment (plasma gun and flux conserver), the magnetic bias coils, and the detailed time dependence of the current source driving the plasma gun, and uses realistic parameters. The simulations are providing a better understanding of the dominant physics in SSPX, including when the flux surfaces close and the mechanisms limiting the efficiency of electrostatic drive

Stability of spheroidal spheromak plasma by use of force-free approximation

International Nuclear Information System (INIS)

Kaneko, Shobu; Tsutsui, Hiroaki.

1987-09-01

The Woltjer-Taylor method is applied to spheromak plasmas in spheroidal flux conservers. As models of the flux conserver, both oblate and prolate spheroidal vessels with a center conductor are used. The plasma is not assumed to be nearly spherical, and the Rayleigh-Ritz method and the finite element method are used to evaluate the eigenvalues. The oblate spheromak is shown to be stable irrespective of the shape of the flux conserver. Though the prolate spheromak is unstable if there is no center conductor, it can be stable if the center conductor is installed. (author)

Theoretical investigation of field-line quality in a driven spheromak

International Nuclear Information System (INIS)

Cohen, R.H.; Cohen, B.I.; Berk, H.L.

2003-01-01

Theoretical studies aimed at predicting and diagnosing field-line quality in a spheromak are described. These include nonlinear 3-D MHD simulations, stability studies, analyses of confinement in spheromaks dominated by either open (stochastic) field lines or approximate flux surfaces, and a theory of fast electrons as a probe of field-line length. (author)

Reactivation of CDX2 in Gastric Cancer as Mark for Gene Silencing Memory

International Nuclear Information System (INIS)

Kameoka, Yuri; Kitazawa, Riko; Ariasu, Kanazu; Tachibana, Ryosuke; Mizuno, Yosuke; Haraguchi, Ryuma; Kitazawa, Sohei

2015-01-01

To explore the epigenetic mechanism that reactivates CDX2 (a homeobox transcription factor that serves as a tumor-suppressor gene) in intestinal-type gastric cancer during cancer progression, we examined the methylation status of the CDX2 gene promoter and the expression pattern of methyl-CpG binding protein-2 (MeCP2). From archives of the pathology records of surgically excised advanced stomach cancer cases in the Department of Molecular Pathology, Ehime University in a past decate (n=265), 10 cases of intestinal-type tubular adenocarcinoma, well-differentiated type (wel) with minor poorly-differentiated adenocarcinoma (por) components were selected. The expression pattern of CDX2, MUC2 and MeCP2 in these 10 cases was analyzed by immunohistochemistry. The cancerous and non-cancerous areas were selectively obtained by microdissection, and the methylation status of the CDX2 promoter of each area was assessed by methylation-specific polymerase chain reaction (MSP). In all 10 cases, CDX2 expression was clearly observed in the nucleus of the non-cancerous background of the intestinal metaplasic area, where the unmethylation pattern of the CDX2 gene promoter prevailed with reduced MeCP2 expression. In this metaplastic area, CDX2 expression was co-localized with its target gene, MUC2. CDX2 expression then disappeared from the deep invasive wel area. Reflecting the reduced CDX2 expression, microdissected samples from all the wel areas showed hypermethylation of the CDX2 gene promoter by MSP, with prominent MeCP2 expression. Interestingly, while hypermethylation of the CDX2 gene promoter was maintained in the por area in 8 of the 10 cases, CDX2 expression was restored in por areas where MeCP2 expression was markedly and selectively reduced. The other two cases, however, showed a constant MeCP2 expression level comparable to the surrounding deep invasive wel area with negative CDX2 expression. Therefore, gene silencing by hypermethylation may be overcome by the reduction of

Prognostic, predictive and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer.

Science.gov (United States)

Bruun, Jarle; Sveen, Anita; Barros, Rita; Eide, Peter W; Eilertsen, Ina; Kolberg, Matthias; Pellinen, Teijo; David, Leonor; Svindland, Aud; Kallioniemi, Olli; Guren, Marianne G; Nesbakken, Arild; Almeida, Raquel; Lothe, Ragnhild A

2018-06-14

We aimed to refine the value of CDX2 as an independent prognostic and predictive biomarker in colorectal cancer (CRC) according to disease stage and chemotherapy sensitivity in preclinical models. CDX2 expression was evaluated in 1045 stage I-IV primary CRCs by gene expression (n=403) or immunohistochemistry (n=642) and in relation to 5-year relapse-free survival (RFS), overall survival (OS), and chemotherapy. Pharmacogenomic associations between CDX2 expression and 69 chemotherapeutics were assessed by drug screening of 35 CRC cell lines. CDX2 expression was lost in 11.6% of cases and showed independent poor prognostic value in multivariable models. For individual stages, CDX2 was prognostic only in stage IV, independent of chemotherapy. Among stage I-III patients not treated in an adjuvant setting, CDX2 loss was associated with a particularly poor survival in the BRAF-mutated subgroup, but prognostic value was independent of microsatellite instability status and the consensus molecular subtypes In stage III, the 5-year RFS rate was higher among patients with loss of CDX2 who received adjuvant chemotherapy than among patients who did not. The CDX2-negative cell lines were significantly more sensitive to chemotherapeutics than CDX2-positive cells, and the multidrug resistance genes MDR1 and CFTR were significantly downregulated both in CDX2-negative cells and patient tumors. Molecular Oncology (2018) © 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos

NARCIS (Netherlands)

Young, Teddy; Rowland, Jennifer Elizabeth; van de Ven, Cesca; Bialecka, Monika; Novoa, Ana; Carapuco, Marta; van Nes, Johan; de Graaff, Wim; Duluc, Isabelle; Freund, Jean-Noël; Beck, Felix; Mallo, Moises; Deschamps, Jacqueline

2009-01-01

Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis, and caudal urorectal structures. We show that trunk Hox genes stimulate axial extension, as they can largely rescue these Cdx mutant

Fundamental Magnetofluid Physics Studies on the Swarthmore Spheromak Experiment: Reconnection and Sustainment

International Nuclear Information System (INIS)

Brown, M.R.

2001-01-01

The general goal of the Magnetofluids Laboratory at Swarthmore College is to understand how magnetofluid kinetic energy can be converted to magnetic energy as it is in the core of the earth and sun (the dynamo problem) and to understand how magnetic energy can be rapidly converted back to kinetic energy and heat as it is in solar flares (the magnetic reconnection problem). Magnetic reconnection has been studied using the Swarthmore Spheromak Experiment (SSX) which was designed and built under this Junior Faculty Grant. In SSX we generate and merge two rings of magnetized plasma called spheromaks and study their interaction. The spheromaks have many properties similar to solar flares so this work is directly relevant to basic solar physics. In addition, since the spheromak is a magnetic confinement fusion configuration, issues of formation and stability have direct impact on the fusion program

Studies of non-inductive current drive in the CDX-U tokamak

International Nuclear Information System (INIS)

Hwang, Y.S.

1993-01-01

Two types of novel, non-inductive current drive concepts for starting-up and maintaining tokamak discharges, dc-helicity injection and internally-generated pressure-driven currents, have been developed on the CDX-U tokamak. To study the equilibrium and transport of these plasmas, a full set of magnetic diagnostics was installed. By applying a finite element method and a least squares error fitting technique, internal plasma current distributions are reconstructed from the measurements. Electron density distributions were obtained from 2 mm interferometer measurements by a similar least squares error technique utilizing magnetic flux configurations obtained by the magnetic analysis. Neoclassical pressure-driven currents in ECH plasmas are modeled with the reconstructed magnetic structure, using the electron density distribution and the electron temperature profile measured by a Langmuir probe. In the dc-helicity injection scheme, the need to increase injection current and maintain plasma equilibrium restricts possible arrangements. Several injection configurations were investigated, with the best found to be outside injection with a single divertor configuration, where the cathode is placed at the low field side of the x-point. Both pressure-driven and dc-helicity injected tokamaks show the importance of plasma equilibrium in obtaining high plasma current. Programmed vertical field operation has proven to be very important in achieving high plasma current. These non-inductive current drive techniques show great potential as efficient current drive methods for future steady-state and/or long-pulse fusion reactors

Pressure effect on equilibrium configuration of CTCC-2 spheromak

International Nuclear Information System (INIS)

Nishikawa, M.; Kato, Y.; Satomi, N.; Watanabe, K.

1990-01-01

In CTCC-2 experiment, the initial plasma is produced by a magnetized gun and ejected into a metallic aluminum flux conserver (FC) with thickness of 15 mm. The spheromak is formed in the FC during a life time of 1.5 ms, in which the plasma is isolated from any external feeder. A choking-field-generating coil is equipped on the entrance of the spheroidal FC. The choking field is suppressing some leakage of spheromak field along the entrance duct, which is made of thin stainless steel plate (0.8 mm) for rapid penetration of the choking magnetic field. This resistive part acts as an effective plasma current limiter, which produces stable currentless region (flux hole). The flux hole increases magnetic shear without inserting a central conducting pole along the symmetric axis and is controlled to decrease with the choking field strength. Thus, in CTCC-2 spheromak, a stable oblate spheroidal boundary is rigidly fixed by the metal wall of FC and the entrance hole of FC is effectively closed by choking magnetic field, so that it is suitable to investigate precisely a fine structure of configuration. In spheromak configuration whose aspect ratio is near one, the ratio of the magnetic strength at the inner part to that at the outer part on equi-flux surface (mirror ratio) becomes very large in comparison with that of a large aspect ratio. This extreme configuration with a high mirror ratio may be associated with an anisotropic pressure effect even in collisional state like as our experimental condition. They have investigated the pressure effect on spheromak configuration in more detail. The obtained equilibrium profile is grossly explained by a theoretical profile on assuming low beta limit until now. However, the authors observe a systematic discrepancy between a measured poloidal profile and a theoretical one as mentioned

MHD stability analysis of axisymmetric surface current model tokamaks close to the spheromak regime

International Nuclear Information System (INIS)

Honma, Toshihisa; Kaji, Ikuo; Fukai, Ichiro; Kito, Masafumi.

1984-01-01

In the toroidal coordinates, a stability analysis is presented for very low-aspect-ratio tokamaks with circular cross section which is described by a surface current model (SCM) of axisymmetric equilibria. The energy principle determining the stability of plasma is treated without any expansion of aspect ratio. Numerical results show that, owing to the occurrence of the non-axisymmetric (n=1) unstable modes, there exists no MHD-stable ideal SCM spheromak characterized by zero external toroidal vacuum field. Instead, a stable spheromak-type plasma which comes to the ideal SCM spheromak is provided by the configuration with a very weak external toroidal field. Close to the spheromak regime (1.0 1 aspect ratio< = 1.1), the minimum safety factor and the critical β-values increase mo notonically with aspect ratio decreasing from a large value, and curves of βsub(p) versus β in the marginal stability approach to an ideal SCM spheromak line βsub(p)=β. (author)

Steady-state spheromak reactor studies

International Nuclear Information System (INIS)

Krakowski, R.A.; Hagenson, R.L.

1985-01-01

After summarizing the essential elements of a gun-sustained spheromak, the potential for a steady-state is explored by means of a comprehensive physics/engineering/costing model. A range of cost-optimized reactor design points is presented, and the sensitivity of cost to key physics, engineering, and operational variables is reported

Spherical Torus Plasma Interactions with Large-area Liquid Lithium Surfaces in CDX-U

International Nuclear Information System (INIS)

Kaita, R.; Majeski, R.; Boaz, M.; Efthimion, P.; Jones, B.; Hoffman, D.; Kugel, H.; Menard, J.; Munsat, T.; Post-Zwicker, A.; Soukhanovskii, V.; Spaleta, J.; Taylor, G.; Timberlake, J.; Woolley, R.; Zakharov, L.; Finkenthal, M.; Stutman, D.; Antar, G.; Doerner, R.; Luckhardt, S.; Maingi, R.; Maiorano, M.; Smith, S.

2002-01-01

The Current Drive Experiment-Upgrade (CDX-U) device at the Princeton Plasma Physics Laboratory (PPPL) is a spherical torus (ST) dedicated to the exploration of liquid lithium as a potential solution to reactor first-wall problems such as heat load and erosion, neutron damage and activation, and tritium inventory and breeding. Initial lithium limiter experiments were conducted with a toroidally-local liquid lithium rail limiter (L3) from the University of California at San Diego. Spectroscopic measurements showed a clear reduction of impurities in plasmas with the L3, compared to discharges with a boron carbide limiter. The evidence for a reduction in recycling was less apparent, however. This may be attributable to the relatively small area in contact with the plasma, and the presence of high-recycling surfaces elsewhere in the vacuum chamber. This conclusion was tested in subsequent experiments with a fully toroidal lithium limiter that was installed above the floor of the vacuum vessel. The new limiter covered over ten times the area of the L3 facing the plasma. Experiments with the toroidal lithium limiter have recently begun. This paper describes the conditioning required to prepare the lithium surface for plasma operations, and effect of the toroidal liquid lithium limiter on discharge performance

Spherical Torus Plasma Interactions with Large-area Liquid Lithium Surfaces in CDX-U

Energy Technology Data Exchange (ETDEWEB)

R. Kaita; R. Majeski; M. Boaz; P. Efthimion; B. Jones; D. Hoffman; H. Kugel; J. Menard; T. Munsat; A. Post-Zwicker; V. Soukhanovskii; J. Spaleta; G. Taylor; J. Timberlake; R. Woolley; L. Zakharov; M. Finkenthal; D. Stutman; G. Antar; R. Doerner; S. Luckhardt; R. Maingi; M. Maiorano; S. Smith

2002-01-18

The Current Drive Experiment-Upgrade (CDX-U) device at the Princeton Plasma Physics Laboratory (PPPL) is a spherical torus (ST) dedicated to the exploration of liquid lithium as a potential solution to reactor first-wall problems such as heat load and erosion, neutron damage and activation, and tritium inventory and breeding. Initial lithium limiter experiments were conducted with a toroidally-local liquid lithium rail limiter (L3) from the University of California at San Diego. Spectroscopic measurements showed a clear reduction of impurities in plasmas with the L3, compared to discharges with a boron carbide limiter. The evidence for a reduction in recycling was less apparent, however. This may be attributable to the relatively small area in contact with the plasma, and the presence of high-recycling surfaces elsewhere in the vacuum chamber. This conclusion was tested in subsequent experiments with a fully toroidal lithium limiter that was installed above the floor of the vacuum vessel. The new limiter covered over ten times the area of the L3 facing the plasma. Experiments with the toroidal lithium limiter have recently begun. This paper describes the conditioning required to prepare the lithium surface for plasma operations, and effect of the toroidal liquid lithium limiter on discharge performance.

Multilayer mirror and foil filter AXUV diode arrays on CDX-U spherical torus

International Nuclear Information System (INIS)

Soukhanovskii, V. A.; Stutman, D.; Iovea, M.; Finkenthal, M.; Moos, H. W.; Munsat, T.; Jones, B.; Hoffman, D.; Kaita, R.; Majeski, R.

2001-01-01

Recent upgrades to CDX-U spherical torus diagnostics include two 10-channel AXUV diode arrays. The multilayer mirror (MLM) array measures the λ150 O VI brightness profile in the poloidal plane using the Mo/B 4 C synthetic multilayer structures as dispersive elements. The foil filter array has a tangential view and is equipped with interchangeable clear aperture, beryllium and titanium filters. This allows measurements of radiated power, O VI or C V radial distributions, respectively. The O VI and C V emissivity and the radiated power profiles are highly peaked. A Neoclassical impurity accumulation mechanism is considered as an explanation. For radiated power measurements in the T e ≤100 eV plasmas, photon energy dependent corrections must be used in order to account for nonlinear AXUV sensitivity in the range E phot ≤20 eV. The arrays are also used for characterization of resistive MHD phenomena, such as the low m modes, saw-tooth oscillations and internal reconnection events. Based on the successful operation of the diagnostics, a new ultra soft x-ray multilayer mirror diode AXUV diode array monitoring the 34 Aa emissivity distribution of C VI will be built and installed on the National Spherical Torus Experiment

Progress with energy confinement time in the CTX spheromak

International Nuclear Information System (INIS)

Jarboe, T.R.; Fernandez, J.C.; Wysocki, F.J.; Barnes, C.W.; Henins, I.; Knox, S.O.; Marklin, G.J.

1990-01-01

The 0.67 m radius mesh flux conserver (MFC) in CTX was replaced by a solid flux conserver (SFC), resulting in greatly reduced field errors. Decreased spheromak open flux led to vastly improved decaying discharged, including increased global energy confinement times, τ E (from 20 to 180 μs), and corresponding magnetic energy decay times, τ B 2 (from 0.7 to 2 ms). Improved confinement allowed the observation of the pressure-driven instability (predicted by Mercier) which ejects plasma from the spheromak interior to the wall

Spheromak Buildup in SSPX using a Modular Capacitor Bank

International Nuclear Information System (INIS)

Wood, R D; McLean, H S; Hill, D N; Hooper, E B; Romero-Talamas, C A

2006-01-01

The Sustained Spheromak Physics Experiment (SSPX) [1] was designed to address both magnetic field generation and confinement. The SSPX produces 1.5-3.5msec, spheromak plasmas with a 0.33m major radius and a minor radius of ∼0.23m. DC coaxial helicity injection is used to build and sustain the spheromak plasma within the flux conserver. Optimal operation is obtained by flattening the profile of λ = μ 0 j/B, consistent with reducing the drive for tearing and other MHD modes, and matching of edge current and bias flux to minimize |(delta)B/B| rms . With these optimizations, spheromak plasmas with central T e >350eV and β e ∼ 5% with toroidal fields of 0.6T [3] have been obtained. If a favorable balance between current drive efficiency and energy confinement can be shown, the spheromak has the potential to yield an attractive magnetic fusion concept [4]. The original SSPX power system consists of two lumped-circuit capacitor banks with fixed circuit parameters. This power system is used to produce an initial fast formation current pulse (10kV, 0.5MJ formation bank), followed by a lower current, 3.5ms flattop sustainment pulse (5kV, 1.5MJ sustainment bank). Experimental results indicate that a variety of injected current pulses, such as a longer sustainment flattop [5], higher and longer fast formation [6], and multiple current pulses [7], might further our understanding of magnetic field generation. Although the formation bank can be split into two independent banks capable of producing other injected current waveforms, the variety of current waveforms produced by this power system is limited. Thus, to extend the operating range of the SSPX, a new pulsed-power system has been designed and partially constructed. In this paper, we discuss the design of the programmable bank and present first results from using the bank to increase the magnetic field in SSPX

Power balance and characterization of impurities in the Maryland Spheromak

International Nuclear Information System (INIS)

Cote, C.

1993-01-01

The Maryland Spheromak is a medium size magnetically confined plasma of toroidal shape. Low T e and higher n e than expected contribute to produce a radiation dominated short-lived spheromak configuration. A pyroelectric radiation detector and a VUV spectrometer have been used for space and time-resolved measurements of radiated power and impurity line emission. Results from the bolometry and VUV spectroscopy diagnostics have been combined to give the absolute concentrations of the major impurity species together with the electron temperature. The large amount of oxygen and nitrogen ions in the plasma very early in the discharge is seen to be directly responsible for the abnormally high electron density. The dominant power loss mechanisms are found to be radiation (from impurity line emission) and electron convection to the end walls during the formation phase of the spheromak configuration, and radiation only during the decay phase

Power balance and characterization of impurities in the Maryland Spheromak

Energy Technology Data Exchange (ETDEWEB)

Cote, Claude [Univ. of Maryland, College Park, MD (United States)

1993-01-01

The Maryland Spheromak is a medium size magnetically confined plasma of toroidal shape. Low T_e and higher n_e than expected contribute to produce a radiation dominated short-lived spheromak configuration. A pyroelectric radiation detector and a VUV spectrometer have been used for space and time-resolved measurements of radiated power and impurity line emission. Results from the bolometry and VUV spectroscopy diagnostics have been combined to give the absolute concentrations of the major impurity species together with the electron temperature. The large amount of oxygen and nitrogen ions in the plasma very early in the discharge is seen to be directly responsible for the abnormally high electron density. The dominant power loss mechanisms are found to be radiation (from impurity line emission) and electron convection to the end walls during the formation phase of the spheromak configuration, and radiation only during the decay phase.

Multi-pulse power injection and spheromak sustainment in SSPX

Science.gov (United States)

Stallard, B. W.; Hill, D. N.; Hooper, E. B.; Bulmer, R. H.; McLean, H. S.; Wood, R. D.; Woodruff, S.; Sspx Team

2000-10-01

Lawrence Livermore National Laboratory, Livermore, CA 94550, USA. Spheromak formation (gun injection phase) and sustainment experiments are now routine in SSPX using a multi-bank power system. Gun voltage, impedance, and power coupling show a clear current threshold dependence on gun flux (I_th~=λ_0φ_gun/μ_0), increasing with current above the threshold, and are compared with CTX results. The characteristic gun inductance, L_gun~=0.6 μH, derived from the gun voltage dependence on di/dt, is larger than expected from Corsica modeling of the spheromak equilibrium. It’s value is consistent with the n=1 ‘doughook’ mode structure reported in SPHEX and believed important for helicity injection and toroidal current drive. Results of helicity and power balance calculations of spheromak poloidal field buildup are compared with experiment and used to project sustainment with a future longer pulse power supply. This work was performed under the auspices of US DOE by the University of California Lawrence Livermore National Laboratory under Contract No. W-7405-ENG-48.

The clinical perspectives of CDX2 expression in colorectal cancer

DEFF Research Database (Denmark)

Olsen, Jesper; Espersen, Maiken Lise Marcker; Jess, P

2014-01-01

, however the expression pattern may often be heterogeneous within the tumor and can be selectively down regulated at the invasive front and in tumor buddings. Loss of CDX2 expression is probably correlated to tumor grade, stage, right-sided tumor location, MMR-deficiency, CIMP, and BRAF mutations. The CDX2...

Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2)

DEFF Research Database (Denmark)

Boyd, Mette; Hansen, Morten; Jensen, Tine G K

2010-01-01

The CDX2 transcription factor is known to play a crucial role in inhibiting proliferation, promoting differentiation and the expression of intestinal specific genes in intestinal cells. The overall effect of CDX2 in intestinal cells has previously been investigated in conditional knock-out mice......, revealing a critical role of CDX2 in the formation of the normal intestinal identity. The identification of direct targets of transcription factors is a key problem in the study of gene regulatory networks. The ChIP-seq technique combines chromatin immunoprecipitation (ChIP) with next generation sequencing...... resulting in a high throughput experimental method of identifying direct targets of specific transcription factors. The method was applied to CDX2, leading to the identification of the direct binding of CDX2 to several known and novel target genes in the intestinal cell. Examination of the transcript levels...

The Homeodomain Transcription Factor Cdx1 Does Not Behave as an Oncogene in Normal Mouse Intestine

Directory of Open Access Journals (Sweden)

Mary Ann S. Crissey

2008-01-01

Full Text Available The Caudal-related homeobox genes Cdx1 and Cdx2 are intestine-specific transcription factors that regulate differentiation of intestinal cell types. Previously, we have shown Cdx1 to be antiproliferative and to promote cell differentiation. However, other studies have suggested that Cdx1 may be an oncogene. To test for oncogenic behavior, we used the murine villin promoter to ectopically express Cdx1 in the small intestinal villi and colonic surface epithelium. No changes in intestinal architecture, cell differentiation, or lineage selection were observed with expression of the transgene. Classic oncogenes enhance proliferation and induce tumors when ectopically expressed. However, the Cdx1 transgene neither altered intestinal proliferation nor induced spontaneous intestinal tumors. In a murine model for colitis-associated cancer, the Cdx1 transgene decreased, rather than increased, the number of adenomas that developed. In the polyps, the expression of the endogenous and the transgenic Cdx1 proteins was largely absent, whereas endogenous Villin expression was retained. This suggests that transgene silencing was specific and not due to a general Villin inactivation. In conclusion, neither the ectopic expression of Cdx1 was associated with changes in intestinal cell proliferation or differentiation nor was there increased intestinal cancer susceptibility. Our results therefore suggest that Cdx1 is not an oncogene in normal intestinal epithelium.

Measurement of magnetic properties of confined compact toroid plasma (spheromak)

International Nuclear Information System (INIS)

Hwang, Fu-Kwun.

1991-01-01

The theoretical aspect of the spheromak is described in this paper. The MS machine hardware will be explored along with the formation scheme and diagnostic systems. The magnetic pickup probes, their calibration procedures and the data analysis methods will be discussed. Observations from the probe measurements and magnetic properties of the MS spheromak are considered. The axisymmetric Grad-Shafranov equilibrium code calculations are presented and compared with the measurements. Magnetic helicity and its correlation with the experimental observations is described

The Homeodomain Transcription Factor Cdx1 Does Not Behave as an Oncogene in Normal Mouse Intestine1

Science.gov (United States)

Crissey, Mary Ann S; Guo, Rong-Jun; Fogt, Franz; Li, Hong; Katz, Jonathan P; Silberg, Debra G; Suh, Eun Ran; Lynch, John P

2008-01-01

The Caudal-related homeobox genes Cdx1 and Cdx2 are intestine-specific transcription factors that regulate differentiation of intestinal cell types. Previously, we have shown Cdx1 to be antiproliferative and to promote cell differentiation. However, other studies have suggested that Cdx1 may be an oncogene. To test for oncogenic behavior, we used the murine villin promoter to ectopically express Cdx1 in the small intestinal villi and colonic surface epithelium. No changes in intestinal architecture, cell differentiation, or lineage selection were observed with expression of the transgene. Classic oncogenes enhance proliferation and induce tumors when ectopically expressed. However, the Cdx1 transgene neither altered intestinal proliferation nor induced spontaneous intestinal tumors. In a murine model for colitis-associated cancer, the Cdx1 transgene decreased, rather than increased, the number of adenomas that developed. In the polyps, the expression of the endogenous and the transgenic Cdx1 proteins was largely absent, whereas endogenous Villin expression was retained. This suggests that transgene silencing was specific and not due to a general Villin inactivation. In conclusion, neither the ectopic expression of Cdx1 was associated with changes in intestinal cell proliferation or differentiation nor was there increased intestinal cancer susceptibility. Our results therefore suggest that Cdx1 is not an oncogene in normal intestinal epithelium. PMID:18231635

Simulation of multi-pulse coaxial helicity injection in the Sustained Spheromak Physics Experiment

Science.gov (United States)

O'Bryan, J. B.; Romero-Talamás, C. A.; Woodruff, S.

2018-03-01

Nonlinear, numerical computation with the NIMROD code is used to explore magnetic self-organization during multi-pulse coaxial helicity injection in the Sustained Spheromak Physics eXperiment. We describe multiple distinct phases of spheromak evolution, starting from vacuum magnetic fields and the formation of the initial magnetic flux bubble through multiple refluxing pulses and the eventual onset of the column mode instability. Experimental and computational magnetic diagnostics agree on the onset of the column mode instability, which first occurs during the second refluxing pulse of the simulated discharge. Our computations also reproduce the injector voltage traces, despite only specifying the injector current and not explicitly modeling the external capacitor bank circuit. The computations demonstrate that global magnetic evolution is fairly robust to different transport models and, therefore, that a single fluid-temperature model is sufficient for a broader, qualitative assessment of spheromak performance. Although discharges with similar traces of normalized injector current produce similar global spheromak evolution, details of the current distribution during the column mode instability impact the relative degree of poloidal flux amplification and magnetic helicity content.

Effects of homeodomain protein CDX2 expression on the proliferation and migration of lovo colon cancer cells.

Science.gov (United States)

Zheng, Jian-bao; Sun, Xue-jun; Qi, Jie; Li, Shou-shuai; Wang, Wei; Ren, Hai-liang; Tian, Yong; Lu, Shao-ying; Du, Jun-kai

2011-09-01

The homeobox gene, CDX2, plays a major role in development, especially in the gut, and also functions as a tumor suppressor in the adult colon. In the present study, we investigated the effects of CDX2 expression on the proliferation, migration, and apoptosis of the human colon cancer cell line, Lovo. Lovo cells exogenously expressing CDX2 exhibited no significant differences in the percentage of cells in G1- and S-phase or in apoptosis, as determined by flow cytometry. MTT assay also confirmed that CDX2 expression had no effect on proliferation in these cells. Interestingly, conditioned medium collected from CDX2-overexpressing Lovo cells showed a significant decrease in secretion of MMP-2 and the invasive potential of these cells was significantly inhibited. Collectively, these data suggest that CDX2 may play a critical role in the migration and metastasis of colon carcinoma and over-expression of CDX2 in colon cancer cells markedly inhibits invasion. Based on these results, exogenous expression of CDX2 might be a promising option in the treatment of colon carcinoma.

Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer.

Directory of Open Access Journals (Sweden)

Yutaka Naito

Full Text Available REG4, which encodes Reg IV protein, is a member of the calcium-dependent lectin superfamily and potent activator of the epidermal growth factor receptor/Akt/activator protein-1 signaling pathway. Several human cancers overexpress Reg IV, and Reg IV expression is associated with intestinal phenotype differentiation. However, regulation of REG4 transcription remains unclear. In the present study, we investigated whether CDX2 regulates Reg IV expression in gastric cancer (GC cells. Expression of Reg IV and CDX2 was analyzed by Western blot and quantitative reverse transcription-polymerase chain reaction in 9 GC cell lines and 2 colon cancer cell lines. The function of the 5'-flanking region of the REG4 gene was characterized by luciferase assay. In 9 GC cell lines, endogenous Reg IV and CDX2 expression were well correlated. Using an estrogen receptor-regulated form of CDX2, rapid induction of Reg IV expression was observed in HT-29 cells. Reporter gene assays revealed an important role in transcription for consensus CDX2 DNA binding elements in the 5'-flanking region of the REG4 gene. Chromatin immunoprecipitation assays showed that CDX2 binds directly to the 5'-flanking region of REG4. These results indicate that CDX2 protein directly regulates Reg IV expression.

Prospects for spheromak fusion reactors

International Nuclear Information System (INIS)

Fowler, T.K.; Hua, D.D.

1995-01-01

The reactor study of Hagenson and Krakowski demonstrated the attractiveness of the spheromak as a compact fusion reactor, based on physics principles confirmed in CTX experiments in many respects. Most uncertain was the energy confinement time and the role of magnetic turbulence inherent in the concept. In this paper, a one-dimensional model of heat confinement, calibrated by CTX, predicts negligible heat loss by magnetic turbulence at reactor scale

Confinement requirements for OHMIC-compressive ignition of a Spheromak plasma

International Nuclear Information System (INIS)

Olson, R.; Gilligan, J.; Miley, G.

1980-01-01

The Moving Plasmoid Reactor (MPR) is an attractive alternative magnetic fusion scheme in which Spheromak plasmoids are envisioned to be formed, compressed, burned, and expanded as the plasmoids translate through a series of linear reactor modules. Although auxiliary heating of the plasmoids may be possible, the MPR scenario would be especially interesting if ohmic decay and compression along were sufficient to heat the plasmoids to an ignition temperature. In the present work, we will study the transport conditions under which a Spheromak plasmoid could be expected to reach ignition via a combination of ohmic and compression heating

Confinement requirements for ohmic-compressive ignition of a Spheromak plasma

International Nuclear Information System (INIS)

Olson, R.E.; Miley, G.H.

1981-01-01

The Moving Plasmoid Reactor (MPR) is an attractive alternative magnetic fusion scheme in which Spheromak plasmoids are envisioned to be formed, compressed, burned, and expanded as the plasmoids translate through a series of linear reactor modules. Although auxiliary heating of the plasmoids may be possible, the MPR scenario would be especially interesting if ohmic decay and compression alone is sufficient to heat the plasmoids to an ignition temperature. In the present work, we examine the transport conditions under which a Spheromak plasmoid can be expected to reach ignition via a combination of ohmic and compression heating

CDX2 prognostic value in stage II/III resected colon cancer is related to CMS classification.

Science.gov (United States)

Pilati, C; Taieb, J; Balogoun, R; Marisa, L; de Reyniès, A; Laurent-Puig, P

2017-05-01

Caudal-type homeobox transcription factor 2 (CDX2) is involved in colon cancer (CC) oncogenesis and has been proposed as a prognostic biomarker in patients with stage II or III CC. We analyzed CDX2 expression in a series of 469 CC typed for the new international consensus molecular subtype (CMS) classification, and we confirmed results in a series of 90 CC. Here, we show that lack of CDX2 expression is only present in the mesenchymal subgroup (CMS4) and in MSI-immune tumors (CMS1) and not in CMS2 and CMS3 colon cancer. Although CDX2 expression was a globally independent prognostic factor, loss of CDX2 expression is not associated with a worse prognosis in the CMS1 group, but is highly prognostic in CMS4 patients for both relapse free and overall survival. Similarly, lack of CDX2 expression was a bad prognostic factor in MSS patients, but not in MSI. Our work suggests that combination of the consensual CMS classification and lack of CDX2 expression could be a useful marker to identify CMS4/CDX2-negative patients with a very poor prognosis. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

New mode of operating a magnetized coaxial plasma gun for injecting magnetic helicity into a spheromak

International Nuclear Information System (INIS)

Woodruff, S.; Hill, D.N.; Stallard, B.W.; Bulmer, R.; Cohen, B.; Holcomb, C.T.; Hooper, E.B.; McLean, H.S.; Moller, J.; Wood, R.D.

2003-01-01

By operating a magnetized coaxial plasma gun continuously with just sufficient current to enable plasma ejection, large gun-voltage spikes (∼1 kV) are produced, giving the highest sustained voltage ∼500 V and highest sustained helicity injection rate observed in the Sustained Spheromak Physics Experiment. The spheromak magnetic field increases monotonically with time, exhibiting the lowest fluctuation levels observed during formation of any spheromak (B-tilde)/B≥2%). The results suggest an important mechanism for field generation by helicity injection, namely, the merging of helicity-carrying filaments

New mode of operating a magnetized coaxial plasma gun for injecting magnetic helicity into a spheromak.

Science.gov (United States)

Woodruff, S; Hill, D N; Stallard, B W; Bulmer, R; Cohen, B; Holcomb, C T; Hooper, E B; McLean, H S; Moller, J; Wood, R D

2003-03-07

By operating a magnetized coaxial plasma gun continuously with just sufficient current to enable plasma ejection, large gun-voltage spikes (approximately 1 kV) are produced, giving the highest sustained voltage approximately 500 V and highest sustained helicity injection rate observed in the Sustained Spheromak Physics Experiment. The spheromak magnetic field increases monotonically with time, exhibiting the lowest fluctuation levels observed during formation of any spheromak (B/B>/=2%). The results suggest an important mechanism for field generation by helicity injection, namely, the merging of helicity-carrying filaments.

Route to High Temperatures by Current Amplification in the Sustained Spheromak Physics Experiment (SSPX)

International Nuclear Information System (INIS)

Woodruff, S.; Holbomb, C. T.; Stallard, B. W.; Hill, D. N.; Hooper, E. B.; McLean, H. S.; Wood, R. D.; Bulmer, R.; Cohen, B.; Sovinec, C.; Pearlstein, L. D.

2002-01-01

For the spheromak to be attractive as a reactor concept it would be necessary to sustain the configuration with a low recycling power, reflected in the current amplification factor: A 1 = I tor /I gun , where I tor is the toroidal current and I gun is the gun current. It is understood that A 1 needs to be around 60 for a reactor [1], although the highest obtained so far in the spheromak has been ∼3 [2]. The spheromak is a simply connected toroidal confinement device related to the reversed field pinch in that the q-profile falls at the edge and the first wall is conducting, although the central solenoid is absent. In the spheromak, the paradigm for field generation (and hence current amplification) is the injection of helicity, K = ∫A.BdV = 2ΦΨ where φ and Ψ are linked fluxes. Helicity is additive in the process of electrostatic injection by a coaxial gun [3]: K = 2V gunΨgun , where V gun is the voltage applied between two coaxial electrodes (giving the rate of toroidal flux injection) and Ψ gun is the poloidal vacuum flux connecting them. SSPX [4] is a 1m wide coaxial-gun-driven spheromak with W-coated copper electrodes (FIGURE 1) and a uniquely programmable vacuum field configuration. SSPX was built to assess if confinement can be reasonably preserved during injection, and to address the specific physics of the processes governing helicity injection

Role of Cdx and Hox genes in posterior axial extension in the mouse

NARCIS (Netherlands)

Young, T.

2009-01-01

Hox and Cdx genes are phylogenetically related transcription factor-encoding genes that control positional tissue identity during embryonic develop- ment. In addition, mutations impairing Cdx activity in mice elicit poste- rior body truncations, affecting the axial skeleton, the neuraxis and cau-

Relaxation phenomena in the high temperature S-1 spheromak

International Nuclear Information System (INIS)

Ono, Y.; Ellis, R.A. Jr.; Janos, A.C.; Levinton, F.M.; Mayo, R.M.; Motley, R.W.; Ueda, Y.; Yamada, M.

1988-06-01

Operation of the S-1 device in a high current density (j/n/sub e/ ≥ 2 /times/ 10 -14 A/center dot/m) regime has created high electron temperature spheromaks (50eV ≤ T/sub e/ ≤ 130eV). The mechanisms and causes of the periodic relaxation events often observed in these hotter spheromak plasmas were made clear. Also, a relationship between the MHD relaxation cycle and confinement characteristics was revealed for the first time. Resistive loss at the outer edge of the plasma causes a departure from the initial force-free minimum-energy Taylor state to a MHD profile unstable to low-n ideal MHD modes; a relaxation event then returns the configuration to nearly a Taylor state. 11 refs., 5 figs

CDX2 hox gene product in a rat model of esophageal cancer

Directory of Open Access Journals (Sweden)

Rizzetto Christian

2009-08-01

Full Text Available Abstract Background Barrett's mucosa is the precursor of esophageal adenocarcinoma. The molecular mechanisms behind Barrett's carcinogenesis are largely unknown. Experimental models of longstanding esophageal reflux of duodenal-gastric contents may provide important information on the biological sequence of the Barrett's oncogenesis. Methods The expression of CDX2 hox-gene product was assessed in a rat model of Barrett's carcinogenesis. Seventy-four rats underwent esophago-jejunostomy with gastric preservation. Excluding perisurgical deaths, the animals were sacrificed at various times after the surgical treatment (Group A: 30 weeks. Results No Cdx2 expression was detected in either squamous epithelia of the proximal esophagus or squamous cell carcinomas. De novo Cdx2 expression was consistently documented in the proliferative zone of the squamous epithelium close to reflux ulcers (Group A: 68%; Group B: 64%; Group C: 80%, multilayered epithelium and intestinal metaplasia (Group A: 9%; Group B: 41%; Group C: 60%, and esophageal adenocarcinomas (Group B: 36%; Group C: 35%. A trend for increasing overall Cdx2 expression was documented during the course of the experiment (p = 0.001. Conclusion De novo expression of Cdx2 is an early event in the spectrum of the lesions induced by experimental gastro-esophageal reflux and should be considered as a key step in the morphogenesis of esophageal adenocarcinoma.

CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia

DEFF Research Database (Denmark)

Pinto, Rita; Barros, Rita; Pereira-Castro, Isabel

2015-01-01

lesions and in the intestine, CDX2 homeobox transcription factor is co-expressed with STn and ST6GalNAc-I. We therefore hypothesized that CDX2 might induce STn expression by positive regulation of ST6GalNAc-I. We showed that ST6GalNAc-I transcript levels and CDX2 have a coordinated expression upon Caco-2...... in vitro differentiation, and overexpression of CDX2 in MKN45 gastric cells increases ST6GalNAc-I transcript levels. Nine putative CDX-binding sites in the ST6GalNAc-I-regulatory sequence were identified and analyzed by chromatin immunoprecipitation in Caco-2 cells and in IM. The results showed that CDX2...... protein is recruited to all regions, being the most proximal sites preferentially occupied in vivo. Luciferase assays demonstrated that CDX2 is able to transactivate ST6GalNac-I-regulatory region. The induction was stronger for the regions mapped in the neighbourhood of ATG start codon and site...

Theory of the evolution of the decaying spheromak

International Nuclear Information System (INIS)

Sgro, A.G.; Marklin, G.; Mirin, A.A.

1986-01-01

The strongly nonlinear dynamics present in decaying Spheromaks has been studied by various computational methods, demonstrating the tendency of the plasma to oscillate about or approach relaxed states and resulting in new insight into the significance of minimum energy states

High aspect ratio spheromak experiments

International Nuclear Information System (INIS)

Robertson, S.; Schmid, P.

1987-05-01

The Reversatron RFP (R/a = 50cm/8cm) has been operated as an ohmically heated spheromak of high aspect ratio. We find that the dynamo can drive the toroidal field upward at rates as high as 10 6 G/sec. Discharges can be initiated and ramped upward from seed fields as low as 50 G. Small toroidal bias fields of either polarity (-0.2 < F < 0.2) do not significantly affect operation. 5 refs., 3 figs

The spheromak as a prototype for ultra-high-field superconducting magnets

International Nuclear Information System (INIS)

Furth, H.P.; Jardin, S.C.

1987-08-01

In view of current progress in the development of superconductor materials, the ultimate high-field limit of superconducting magnets is likely to be set by mechanical stress problems. Maximum field strength should be attainable by means of approximately force-free magnet windings having favorable ''MHD'' stability properties (so that small winding errors will not grow). Since a low-beta finite-flux-hole spheromak configuration qualifies as a suitable prototype, the theoretical and experimental spheromak research effort of the past decade has served to create a substantial technical basis for the design of ultra-high-field superconducting coils. 11 refs

Asymmetric Localization of Cdx2 mRNA during the First Cell-Fate Decision in Early Mouse Development

Directory of Open Access Journals (Sweden)

Maria Skamagki

2013-02-01

Full Text Available A longstanding question in mammalian development is whether the divisions that segregate pluripotent progenitor cells for the future embryo from cells that differentiate into extraembryonic structures are asymmetric in cell-fate instructions. The transcription factor Cdx2 plays a key role in the first cell-fate decision. Here, using live-embryo imaging, we show that localization of Cdx2 transcripts becomes asymmetric during development, preceding cell lineage segregation. Cdx2 transcripts preferentially localize apically at the late eight-cell stage and become inherited asymmetrically during divisions that set apart pluripotent and differentiating cells. Asymmetric localization depends on a cis element within the coding region of Cdx2 and requires cell polarization as well as intact microtubule and actin cytoskeletons. Failure to enrich Cdx2 transcripts apically results in a significant decrease in the number of pluripotent cells. We discuss how the asymmetric localization and segregation of Cdx2 transcripts could contribute to multiple mechanisms that establish different cell fates in the mouse embryo.

Structure of Maryland Spheromak plasmas

International Nuclear Information System (INIS)

Hess, R.; Chinfatt, C.; Cote, C.; DeSilva, A.; Filuk, A.; Goldenbaum, G.; Gauvreau, J.; Hwang, Fukwun

1990-01-01

Recent efforts on the Maryland Spheromak (MS) have concentrated on detailed measurement of magnetic field structures in order to better understand the formation and evolution of the spheromak configuration. These efforts were prompted by results showing a very rapid decay of the magnetic field under certain conditions. It was not known if this loss was a rapid movement of the plasma to the walls of the vacuum vessel, or by some mechanism causing a rapid decay of a more or less stationary field. To investigate the magnetic field structure in more detail, an array of magnetic probes was built that could be moved from shot to shot so as to acquire a complete map of the three magnetic field components in a plane containing the symmetry axis of the machine. Data taken with these probes in a case where the rapid loss of field occurs is given. Further analysis of the data shows that the instability that forms is a combination of tilt and shift. The initial asymmetry of the magnetic field is possibly due to the non-symmetric configuration of the reversal field coils, or the non-symmetric cabling to the I z electrodes. Future work will concentrate on eliminating the initial plasma asymmetry by eliminating any asymmetries in the machine, and on stopping the tilt/shift instability by different configurations for the passive stabilization coils

Progress in the SSPX Spheromak

International Nuclear Information System (INIS)

McLean, H S; Woodruff, S; Hill, D N; Bulmer, R H; Cohen, B I; Hooper, E B; Moller, J; Ryutov, D D; Stallard, B W; Wood, R D; Holcomb, C T; Jarboe, T R; Romero-Talamas, C

2003-01-01

The spheromak, with its simply connected geometry, holds promise as a less expensive fusion reactor. It has reasonably good plasma beta and can be formed and sustained in steady state with a magnetized coaxial plasma gun. The Sustained Spheromak Physics Experiment (SSPX) shown in Fig. 1 was constructed to investigate the key issues of magnetic field generation and energy confinement. In addition to the coaxial gun, nine magnetic field coils are utilized to shape the vacuum magnetic flux. This flexibility allows operation in many different regimes producing very different plasma characteristics. Pulse length is extended and magnetic field strength is increased. Improved surface conditioning produces plasmas with low impurity content, and higher electron temperature, T e . Electron heat transport within the separatrix is reduced by a factor of 4. The results strongly suggest the existence of closed flux surfaces even though the plasma is connected to the coaxial source. The CORSICA Grad-Shafranov 2-d equilibrium code with data from edge magnetic probes along with T e and electron density ne from Thomson scattering is used to calculate internal profiles: normalized current γ = μ 0 J/B, safety factor = q, ohmic heating, thermal energy density, and thermal diffusivity = ξ e . Ohmic heating is calculated by assuming spatially constant Spitzer resistivity with Z eff =2.3 estimated by VUV spectroscopy

Formation of a field-reversed configuration by coalescence of spheromaks

International Nuclear Information System (INIS)

Dasgupta, B.; Sato, Tetsuya; Hayashi, Takaya; Watanabe, Kunihiko; Watanabe, Tomohiko

1995-01-01

We present a numerical simulation of the slow formation of FRC by the merging of two spheromaks with opposite toroidal fluxes. A rather important feature of such a method of formation of FRC should be made explicit. A spheromak is basically a Taylor minimum energy state. On the other hand the FRC with its single component poloidal magnetic field and high plasma beta is decidedly far away from a Taylor state. So a numerical simulation of this process, besides demonstrating the feasibility of such FRC formation, is expected to show the traits in the process of transition from a Taylor state to a non-Taylor state. 5 refs., 2 figs., 1 tab

Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models.

Science.gov (United States)

Khandelwal, Garima; Girotti, María Romina; Smowton, Christopher; Taylor, Sam; Wirth, Christopher; Dynowski, Marek; Frese, Kristopher K; Brady, Ged; Dive, Caroline; Marais, Richard; Miller, Crispin

2017-08-01

Patient-derived xenograft (PDX) and circulating tumor cell-derived explant (CDX) models are powerful methods for the study of human disease. In cancer research, these methods have been applied to multiple questions, including the study of metastatic progression, genetic evolution, and therapeutic drug responses. As PDX and CDX models can recapitulate the highly heterogeneous characteristics of a patient tumor, as well as their response to chemotherapy, there is considerable interest in combining them with next-generation sequencing to monitor the genomic, transcriptional, and epigenetic changes that accompany oncogenesis. When used for this purpose, their reliability is highly dependent on being able to accurately distinguish between sequencing reads that originate from the host, and those that arise from the xenograft itself. Here, we demonstrate that failure to correctly identify contaminating host reads when analyzing DNA- and RNA-sequencing (DNA-Seq and RNA-Seq) data from PDX and CDX models is a major confounding factor that can lead to incorrect mutation calls and a failure to identify canonical mutation signatures associated with tumorigenicity. In addition, a highly sensitive algorithm and open source software tool for identifying and removing contaminating host sequences is described. Importantly, when applied to PDX and CDX models of melanoma, these data demonstrate its utility as a sensitive and selective tool for the correction of PDX- and CDX-derived whole-exome and RNA-Seq data. Implications: This study describes a sensitive method to identify contaminating host reads in xenograft and explant DNA- and RNA-Seq data and is applicable to other forms of deep sequencing. Mol Cancer Res; 15(8); 1012-6. ©2017 AACR . ©2017 American Association for Cancer Research.

Controlled and spontaneous magnetic field generation in a gun-driven spheromak

International Nuclear Information System (INIS)

Woodruff, S.; Cohen, B.I.; Hooper, E.B.; Mclean, H.S.; Stallard, B.W.; Hill, D.N.; Holcomb, C.T.; Romero-Talamas, C.; Wood, R.D.; Cone, G.; Sovinec, C.R.

2005-01-01

In the Sustained Spheromak Physics Experiment, SSPX [E. B. Hooper, D. Pearlstein, and D. D. Ryutov, Nucl. Fusion 39, 863 (1999)], progress has been made in understanding the mechanisms that generate fields by helicity injection. SSPX injects helicity (linked magnetic flux) from 1 m diameter magnetized coaxial electrodes into a flux-conserving confinement region. Control of magnetic fluctuations (δB/B∼1% on the midplane edge) yields T e profiles peaked at >200 eV. Trends indicate a limiting beta (β e ∼4%-6%), and so we have been motivated to increase T e by operating with stronger magnetic field. Two new operating modes are observed to increase the magnetic field: (A) Operation with constant current and spontaneous gun voltage fluctuations. In this case, the gun is operated continuously at the threshold for ejection of plasma from the gun: stored magnetic energy of the spheromak increases gradually with δB/B∼2% and large voltage fluctuations (δV∼1 kV), giving a 50% increase in current amplification, I tor /I gun . (B) Operation with controlled current pulses. In this case, spheromak magnetic energy increases in a stepwise fashion by pulsing the gun, giving the highest magnetic fields observed for SSPX (∼0.7 T along the geometric axis). By increasing the time between pulses, a quasisteady sustainment is produced (with periodic good confinement), comparing well with resistive magnetohydrodynamic simulations. In each case, the processes that transport the helicity into the spheromak are inductive and exhibit a scaling of field with current that exceeds those previously obtained. We use our newly found scaling to suggest how to achieve higher temperatures with a series of pulses

Controlled and Spontaneous Magnetic Field Generation in a Gun-Driven Spheromak

International Nuclear Information System (INIS)

Woodruff, S; Cohen, B I; Hooper, E B; McLean, H S; Stallard, B W; Hill, D N; Holcomb, C T; Romero-Talamas, C; Wood, R D; Cone, G; Sovinec, C R

2005-04-01

In the Sustained Spheromak Physics Experiment, SSPX, progress has been made in understanding the mechanisms that generate fields by helicity injection. SSPX injects helicity (linked magnetic flux) from 1-m diameter magnetized coaxial electrodes into a flux-conserving confinement region. Control of magnetic fluctuations ((delta)B/B∼1% on the midplane edge) yields T e profiles peaked at > 200eV. Trends indicate a limiting beta (β e ∼ 4-6%), and so we have been motivated to increase T e by operating with stronger magnetic field. Two new operating modes are observed to increase the magnetic field: (A) Operation with constant current and spontaneous gun voltage fluctuations. In this case, the gun is operated continuously at the threshold for ejection of plasma from the gun: stored magnetic energy of the spheromak increases gradually with (delta)B/B ∼2% and large voltage fluctuations ((delta)V ∼ 1kV), giving a 50% increase in current amplification, I tor /I gun . (B) Operation with controlled current pulses. In this case, spheromak magnetic energy increases in a stepwise fashion by pulsing the gun, giving the highest magnetic fields observed for SSPX (∼0.7T along the geometric axis). By increasing the time between pulses, a quasi-steady sustainment is produced (with periodic good confinement), comparing well with resistive MHD simulations. In each case, the processes that transport the helicity into the spheromak are inductive and exhibit a scaling of field with current that exceeds those previously obtained. We use our newly found scaling to suggest how to achieve higher temperatures with a series of pulses

Association of CDX2 Expression With Survival in Early Colorectal Cancer: A Systematic Review and Meta-analysis.

Science.gov (United States)

Tomasello, Gianluca; Barni, Sandro; Turati, Luca; Ghidini, Michele; Pezzica, Ezio; Passalacqua, Rodolfo; Petrelli, Fausto

2018-02-15

CDX2 is a homeobox gene encoding transcriptional factors for intestinal organogenesis and represents a specific marker of colorectal adenocarcinoma (CRC) differentiation. We have evaluated if CDX2 expression is associated with better overall and disease-free survival (OS and DFS) in patients with CRC. PubMed, SCOPUS, EMBASE, The Cochrane Library, and Web of Science (from inception to July 2017) were systematically reviewed for relevant studies on adult patients with CRC where OS and DFS were calculated according to CDX2 expression in uni- or multivariate analysis were included. Hazard ratio (HR) for mortality and/or disease progression was calculated. The search produced 16 studies suitable for inclusion (6291 individual patients). The meta-analysis showed a reduced risk of death for patients with CDX2-positive CRC in 14 studies (HR, 0.5; 95% confidence interval [CI], 0.38-0.66; P < .001 according to random effect model). In 6 studies where only DFS data was available, CDX2 expression led to a 52% lower risk of relapse or death (HR, 0.48; 95% CI, 0.39-0.59; P < .001 according to random effect model). The results did not change as a function of ethnicity, type of study, CDX2 detection modality, or stage. Interestingly, in stages II to III, CDX2 expression was associated with a 70% lower risk of death (HR, 0.3; 95% CI, 0.12-0.77; P = .01). CDX2 expression confirms to be a strong prognostic factor in stage II and III CRC. In this setting, along with other clinical and pathologic factors, the lack of expression of CDX2 may be considered an important variable when deciding for adjuvant chemotherapy. Copyright © 2018 Elsevier Inc. All rights reserved.

Effects of passive coils on spheromak gross MHD instabilities

International Nuclear Information System (INIS)

Munson, C.; Janos, A.; Paul, S.; Wysocki, F.; Yamada, M.

1983-01-01

The experimental investigation of the effectiveness of figure-8 coils in stabilizing the n=1 tilting mode of spheromak plasmas in Proto S-1 A/B is extended. In addition, another coil configuration, the saddle coil, is examined

Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus.

Directory of Open Access Journals (Sweden)

Jianping Kong

2011-04-01

Full Text Available Barrett's esophagus (BE is an intestinal metaplasia that occurs in the setting of chronic acid and bile reflux and is associated with a risk for adenocarcinoma. Expression of intestine-specific transcription factors in the esophagus likely contributes to metaplasia development. Our objective was to explore the effects of an intestine-specific transcription factor when expressed in the mouse esophageal epithelium. Transgenic mice were derived in which the transcription factor Cdx2 is expressed in squamous epithelium using the murine Keratin-14 gene promoter. Effects of the transgene upon cell proliferation and differentiation, gene expression, and barrier integrity were explored. K14-Cdx2 mice express the Cdx2 transgene in esophageal squamous tissues. Cdx2 expression was associated with reduced basal epithelial cell proliferation and altered cell morphology. Ultrastructurally two changes were noted. Cdx2 expression was associated with dilated space between the basal cells and diminished cell-cell adhesion caused by reduced Desmocollin-3 mRNA and protein expression. This compromised epithelial barrier function, as the measured trans-epithelial electrical resistance (TEER of the K14-Cdx2 epithelium was significantly reduced compared to controls (1189 Ohm*cm(2 ±343.5 to 508 Ohm*cm(2±92.48, p = 0.0532. Secondly, basal cells with features of a transitional cell type, intermediate between keratinocytes and columnar Barrett's epithelial cells, were observed. These cells had reduced keratin bundles and increased endoplasmic reticulum levels, suggesting the adoption of secretory-cell features. Moreover, at the ultrastructural level they resembled "Distinctive" cells associated with multilayered epithelium. Treatment of the K14-Cdx2 mice with 5'-Azacytidine elicited expression of BE-associated genes including Cdx1, Krt18, and Slc26a3/Dra, suggesting the phenotype could be advanced under certain conditions. We conclude that ectopic Cdx2 expression in

Isolation and characterization of the human CDX1 gene: A candidate gene for diastrophic dysplasia

Energy Technology Data Exchange (ETDEWEB)

Bonner, C.; Loftus, S.; Wasmuth, J.J. [Univ. of California, Irvine, CA (United States)

1994-09-01

Diastrophic dysplasia is an autosomal recessive disorder characterized by short stature, dislocation of the joints, spinal deformities and malformation of the hands and feet. Multipoint linkage analysis places the diastrophic dysplasia (DTD) locus in 5q31-5q34. Linkage disequilibrium mapping places the DTD locus near CSFIR in the direction of PDGFRB (which is tandem to CSFIR). This same study tentatively placed PDGFRB and DTD proximal to CSFIR. Our results, as well as recently reported work from other laboratories, suggest that PDGFRB (and possibly DTD) is distal rather than proximal to CSFIR. We have constructed a cosmid contig covering approximately 200 kb of the region containing CSFIR. Several exons have been {open_quotes}trapped{close_quotes} from these cosmids using exon amplification. One of these exons was trapped from a cosmid isolated from a walk from PDGFRB, approximately 80 kb from CSFIR. This exon was sequenced and was determined to be 89% identical to the nucleotide sequence of exon two of the murine CDX1 gene (100% amino acid identity). The exon was used to isolate the human CDX gene. Sequence analysis of the human CDX1 gene indicates a very high degree of homology to the murine gene. CDX1 is a caudal type homeobox gene expressed during gastrulation. In the mouse, expression during gastrulation begins in the primitive streak and subsequently localizes to the ectodermal and mesodermal cells of the primitive streak, neural tube, somites, and limb buds. Later in gastrulation, CDX1 expression becomes most prominent in the mesoderm of the forelimbs, and, to a lesser extent, the hindlimbs. CDX1 is an intriguing candidate gene for diastrophic dysplasia. We are currently screening DNA from affected individuals and hope to shortly determine whether CDX1 is involved in this disorder.

The spheromak as a compact fusion reactor

Energy Technology Data Exchange (ETDEWEB)

Hagenson, R.L.; Krakowski, R.A.

1987-03-01

After summarizing the economic and utility-based rationale for compact, higher-power-density fusion reactors, the gun-sustained spheromak concept is explored as one of a number of poloidal-field-dominated confinement configurations that might improve the prospects for economically attractive and operationally simplified fusion power plants. Using a comprehensive physics/engineering/costing model for the spheromak, guided by realistic engineering constraints and physics extrapolation, a range of cost-optimized reactor design points is presented, and the sensitivity of cost to key physics, engineering, and operational variables is reported. The results presented herein provide the basis for conceptual engineering designs of key fusion-power-core (FPC) subsystems and more detailed plasma modeling of this promising, high mass-power-density concept, which stresses single-piece FPC maintenance, steady-state current drive through electrostatic magnetic helicity injection, a simplified co-axial electrode-divertor, and efficient resistive-coal equilibrium-field coils. The optimal FPC size and the cost estimates project a system that competes aggressively with the best offered by alternative energy sources while simplifying considerably the complexity that has generally been associated with most approaches to magnetic fusion energy.

The spheromak as a compact fusion reactor

International Nuclear Information System (INIS)

Hagenson, R.L.; Krakowski, R.A.

1987-03-01

After summarizing the economic and utility-based rationale for compact, higher-power-density fusion reactors, the gun-sustained spheromak concept is explored as one of a number of poloidal-field-dominated confinement configurations that might improve the prospects for economically attractive and operationally simplified fusion power plants. Using a comprehensive physics/engineering/costing model for the spheromak, guided by realistic engineering constraints and physics extrapolation, a range of cost-optimized reactor design points is presented, and the sensitivity of cost to key physics, engineering, and operational variables is reported. The results presented herein provide the basis for conceptual engineering designs of key fusion-power-core (FPC) subsystems and more detailed plasma modeling of this promising, high mass-power-density concept, which stresses single-piece FPC maintenance, steady-state current drive through electrostatic magnetic helicity injection, a simplified co-axial electrode-divertor, and efficient resistive-coal equilibrium-field coils. The optimal FPC size and the cost estimates project a system that competes aggressively with the best offered by alternative energy sources while simplifying considerably the complexity that has generally been associated with most approaches to magnetic fusion energy

Ion temperature measurements in the Maryland Spheromak

International Nuclear Information System (INIS)

Gauvreau, J.L.

1992-01-01

Initial spectroscopic data from MS showed evidence of ion heating as deduced from the line widths of different ion species. Detailed measurements of OIV spectral emission line profiles in space and time revealed that heating takes place at early time, before spheromak formation and is occurring within the current discharge. The measured ion temperature is several times the electron temperature and cannot be explained by classical (Spitzer) resistivity. Classically, ions are expected to have lower temperatures than the electrons and therefore, lower temperatures than observed. High ion temperatures have been observed in different RFP's and Spheromaks but are usually associated with relaxation to the Taylor state and occur in the sustainment phase. During formation, the current delivered to start the discharge is not axisymmetric and as a consequence, X-points appear in the magnetic flux. A two dimensional analysis predicts that magnetic reconnection occurring at an X-point can give rise to high ion heating rates. A simple 0-dimensional calculation showed that within the first 20 μs, a conversion of mass flow kinetic energy into ion temperature could take place due to viscosity

Model predictions for auxiliary heating in spheromaks

International Nuclear Information System (INIS)

Fauler, T.K.; Khua, D.D.

1997-01-01

Calculations are presented of the plasma temperature waited for under auxiliary heating in spheromaks. A model, ensuring good agreement of earlier experiments with joule heating results, is used. The model includes heat losses due to magnetic fluctuations and shows that the plasma temperatures of the kilo-electron-volt order may be achieved in a small device with the radius of 0.3 m only

Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells

DEFF Research Database (Denmark)

Olsen, Anders Krüger; Coskun, Mehmet; Bzorek, Michael

2013-01-01

was associated with endogenous downregulation of APC and AXIN2 expression in Caco-2 cells but did not affect GSK3β expression. Furthermore, elevated levels of nuclear β-catenin and reduced levels of cytoplasmic APC were correlated to a low CDX2 expression in migrating colon cancer cells in vivo. These results......Wnt signaling is often constitutively active in colorectal cancer cells. The expression of the intestinal specific transcription factor CDX2 is found to be transiently decreased in invasive cells at the tumor/stroma interface. A recent ChIP-Seq study has indicated that several Wnt signaling......-related genes are regulated by CDX2. The aim was to investigate the role of decreased CDX2 level on the expression of APC, AXIN2 and GSK3β in migrating colon cancer cells at the invasive front. CDX2-bound promoter and enhancer regions from APC, AXIN2 and GSK3β were analyzed for gene regulatory activity...

SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

International Nuclear Information System (INIS)

Lundberg, Ida V.; Edin, Sofia; Eklöf, Vincy; Öberg, Åke; Palmqvist, Richard; Wikberg, Maria L.

2016-01-01

To improve current treatment strategies for patients with aggressive colorectal cancer (CRC), the molecular understanding of subgroups of CRC with poor prognosis is of vast importance. SOX2 positive tumors have been associated with a poor patient outcome, but the functional role of SOX2 in CRC patient prognosis is still unclear. An in vitro cell culture model expressing SOX2 was used to investigate the functional role of SOX2 in CRC. In vitro findings were verified using RNA from fresh frozen tumor tissue or immunohistochemistry on formalin fixed paraffin embedded (FFPE) tumor tissue from a cohort of 445 CRC patients. Using our in vitro model, we found that SOX2 expressing cells displayed several characteristics of cancer stem cells; such as a decreased proliferative rate, a spheroid growth pattern, and increased expression of stem cell markers CD24 and CD44. Cells expressing SOX2 also showed down-regulated expression of the intestinal epithelial marker CDX2. We next evaluated CDX2 expression in our patient cohort. CDX2 down-regulation was more often found in right sided tumors of high grade and high stage. Furthermore, a decreased expression of CDX2 was closely linked to MSI, CIMP-high as well as BRAF mutated tumors. A decreased expression of CDX2 was also, in a stepwise manner, strongly correlated to a poor patient prognosis. When looking at SOX2 expression in relation to CDX2, we found that SOX2 expressing tumors more often displayed a down-regulated expression of CDX2. In addition, SOX2 expressing tumors with a down-regulated CDX2 expression had a worse patient prognosis compared to those with retained CDX2 expression. Our results indicate that SOX2 expression induces a cellular stem cell state in human CRC with a decreased expression of CDX2. Furthermore, a down-regulated expression of CDX2 results in a poor patient prognosis in CRC and at least part of the prognostic importance of SOX2 is mediated through CDX2 down-regulation. The online version of this

CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer

DEFF Research Database (Denmark)

Olsen, J.; Eiholm, Susanne; Kirkeby, L T

2016-01-01

adjacent tissue were fixed in liquid nitrogen for RNA extraction or in formalin and paraffin embedded (FFPE) for immunohistochemical staining. CDX2 mRNA expression was evaluated by RT-qPCR. FFPE sections were stained for MLH1, MSH2, MSH6, PMS2, and CDX2. RESULTS: A total of 191 patient samples were...

Particle diffusion in a spheromak

International Nuclear Information System (INIS)

Meyerhofer, D.D.; Levinton, F.M.; Yamada, M.

1988-01-01

The local carbon particle diffusion coefficient was measured in the Proto S-1/C spheromak using a test particle injection scheme. When the plasma was not in a force-free Taylor state, and when there were pressure gradients in the plasma, the particle diffusion was five times that predicted by Bohm and was consistent with collisional drift wave diffusion. The diffusion appears to be driven by correlations of the fluctuating electric field and density. During the decay phase of the discharge when the plasma was in the Taylor state, the diffusion coefficient of the carbon was classical. 23 refs., 4 figs

The role of CDX2 in intestinal homeostasis and inflammation

DEFF Research Database (Denmark)

Coskun, Mehmet; Troelsen, Jesper Thorvald; Nielsen, Ole Haagen

2011-01-01

a causal role in a large number of diseases and developmental disorders. Inflammatory bowel disease (IBD) is characterized by a chronically inflamed mucosa caused by dysregulation of the intestinal immune homeostasis. The aetiology of IBD is thought to be a combination of genetic and environmental factors......, including luminal bacteria. The Caudal-related homeobox transcription factor 2 (CDX2) is critical in early intestinal differentiation and has been implicated as a master regulator of the intestinal homeostasis and permeability in adults. When expressed, CDX2 modulates a diverse set of processes including...... of the intestinal homeostasis and further to reveal its potential role in inflammation....

Effect of composition on SILAR deposited CdxZn1-xS thin films

Science.gov (United States)

Ashith V., K.; Gowrish Rao, K.

2018-04-01

In the group of II-VI compound semiconductor, cadmium zinc sulphide (CdxZn1-xS) thin films have broad application in photovoltaic, optoelectronic devices etc. For heterojunction aspects, CdxZn1-xS thin film can be used as heterojunction partner for CdTe as the absorber layer. In this work, CdZnS thin films prepared on glass substrates by Successive Ion Layer Adsorption and Reaction (SILAR) method by varying the composition. The XRD patterns of deposited films showed polycrystalline with the hexagonal phase. The crystallite size of the films was estimated from W-H plot. The bond length of the film varied w.r.to the composition of the CdxZn1-xS films. The urbach energy of the films was calcualted from absorbance data.

CDX2 Stimulates the Proliferation of Porcine Intestinal Epithelial Cells by Activating the mTORC1 and Wnt/β-Catenin Signaling Pathways.

Science.gov (United States)

Fan, Hong-Bo; Zhai, Zhen-Ya; Li, Xiang-Guang; Gao, Chun-Qi; Yan, Hui-Chao; Chen, Zhe-Sheng; Wang, Xiu-Qi

2017-11-18

Caudal type homeobox 2 (CDX2) is expressed in intestinal epithelial cells and plays a role in gut development and homeostasis by regulating cell proliferation. However, whether CDX2 cooperates with the mammalian target of rapamycin complex 1 (mTORC1) and Wnt/β-catenin signaling pathways to stimulate cell proliferation remains unknown. The objective of this study was to investigate the effect of CDX2 on the proliferation of porcine jejunum epithelial cells (IPEC-J2) and the correlation between CDX2, the mTORC1 and Wnt/β-catenin signaling pathways. CDX2 overexpression and knockdown cell culture models were established to explore the regulation of CDX2 on both pathways. Pathway-specific antagonists were used to verify the effects. The results showed that CDX2 overexpression increased IPEC-J2 cell proliferation and activated both the mTORC1 and Wnt/β-catenin pathways, and that CDX2 knockdown decreased cell proliferation and inhibited both pathways. Furthermore, the mTORC1 and Wnt/β-catenin pathway-specific antagonist rapamycin and XAV939 (3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)]-4H -thiopyrano[4,3-d]pyrimidin-4-one) both suppressed the proliferation of IPEC-J2 cells overexpressing CDX2, and that the combination of rapamycin and XAV939 had an additive effect. Regardless of whether the cells were treated with rapamycin or XAV939 alone or in combination, both mTORC1 and Wnt/β-catenin pathways were down-regulated, accompanied by a decrease in CDX2 expression. Taken together, our data indicate that CDX2 stimulates porcine intestinal epithelial cell proliferation by activating the mTORC1 and Wnt/β-catenin signaling pathways.

TNF-a-induced down-regulation of CDX2 suppresses MEP1A expression in colitis

DEFF Research Database (Denmark)

Coskun, Mehmet; Olsen, Anders Krüger; Holm, Thomas Lindebo

2012-01-01

was investigated in colonic biopsies of ulcerative colitis (UC) patients and in dextran sodium sulfate (DSS)-induced colitis. CDX2 protein expression was investigated by immunoblotting and immunohistochemical procedures. CDX2 and MEP1A regulation was examined in TNF-a-treated Caco-2 cells by reverse transcription...

Equilibrium and stability of the Los Alamos spheromak

International Nuclear Information System (INIS)

Marklin, G.

1984-01-01

The open mesh flux conserver (MFC) on the Los Alamos spheromak (CTX) has been equipped with a large number of Rogowski loops measuring the current in the individual segments of the MFC, providing a complete picture of the surface current pattern induced by the equilibrium and oscillations of the confined plasma. An analysis was made of the data from these Rogowski loops

First-principles calculations of structural, electronic and optical properties of CdxZn1-xS alloys

KAUST Repository

Noor, Naveed Ahmed; Ikram, Nazma; Ali, Sana Zulfiqar; Nazir, Safdar; Alay-E-Abbas, Syed Muhammad; Shaukat, Ali

2010-01-01

Structural, electronic and optical properties of ternary alloy system CdxZn1-xS have been studied using first-principles approach based on density functional theory. Electronic structure, density of states and energy band gap values for CdxZn1-xS

Loss of Cdx2 expression in primary tumors and lymph node metastases is specific for mismatch repair-deficiency in colorectal cancer

Directory of Open Access Journals (Sweden)

Heather eDawson

2013-10-01

Full Text Available Background: Approximately 20% of all colorectal cancers are hypothesized to arise from the serrated pathway characterized by mutation in BRAF, high-level CpG Island Methylator Phenotype (CIMP and microsatellite instability/mismatch repair (MMR-deficiency. MMR-deficient cancers show frequent losses of Cdx2, a homeodomain transcription factor. Here, we determine the predictive value of Cdx2 expression for MMR-deficiency and investigate changes in expression between primary cancers and matched lymph node metastases. Methods: Immunohistochemistry for Cdx2, Mlh1, Msh2, Msh6, and Pms2 was performed on whole tissue sections from 201 patients with primary colorectal cancer and 59 cases of matched lymph node metastases. Receiver operating characteristic (ROC curve analysis and Area under the Curve (AUC were investigated; association of Cdx2 with clinicopathological features and patient survival was carried out.Results Loss of Cdx2 expression was associated with higher tumor grade (p=0.0002, advanced pT (p=0.0166, and perineural invasion (p=0.0228. Cdx2 loss was an unfavorable prognostic factor in univariate (p=0.0145 and multivariate (p=0.0427; HR (95%CI: 0.58 (0.34-0.98 analysis. The accuracy (AUC for discriminating MMR-proficient and –deficient cancers was 87% (OR (95%CI:0.96 (0.95-0.98; p<0.0001. Specificity and negative predictive value for MMR-deficiency was 99.1% and 96.3%. 174 patients had MMR-proficient cancers, of which 60 (34.5% showed Cdx2 loss. Cdx2 loss in metastases was related to MMR-deficiency (p<0.0001. There was no difference in expression between primary tumors and matched metastases.Conclusion: Loss of Cdx2 is a sensitive and specific predictor of MMR-deficiency, but is not limited to these tumors, suggesting that events upstream of the development of MSI may impact Cdx2 expression.

Instantaneous current and field structure of a gun-driven spheromak for two gun polarities

International Nuclear Information System (INIS)

Woodruff, S; Nagata, M

2002-01-01

The instantaneous plasma structure of the SPHEX spheromak is determined here by numerically processing data from insertable Rogowski and magnetic field probes. Data is presented and compared for two modes of gun operation: with the central electrode biased positively and negatively. It is found that while the mean-, or even instantaneous-, field structure would give the impression of a roughly axisymmetric spheromak, the instantaneous current structure does not. Hundred per cent variations in J measured at the magnetic axis can be explained by the rotation of a current filament that has a width equal to half of the radius of the flux-conserving first wall. In positive gun operation, current leaves the filament in the confinement region leading to high wall current there. In negative gun operation, wall current remains low as all injected current returns to the gun through the plasma. The plasma, in either instance, is strongly asymmetric. We discuss evidence for the existence of the current filament in other gun-driven spheromaks and coaxial plasma thrusters

Critical beta for analytical spheromak equilibria

International Nuclear Information System (INIS)

Freire, E.M.; Clemente, R.A.

1985-01-01

The Mercier criterion is applied to two analytical spheromak equilibria, one with a spherical separatrix and the other with a cylindrical one of variable elongation. The maximum beta, defined as the ratio between the plasma pressure and the magnetic pressure averaged over the plasma volume, for which the criterion is satisfied on every magnetic surface, has been obtained. In the spherical model the critical beta is 0.003, while in the cylindrical case it is a function of the elongation of the separatrix with a maximum of 0.083. (author)

Field-Reversed Configuration Formation Scheme Utilizing a Spheromak and Solenoid Induction

International Nuclear Information System (INIS)

Gerhardt, S.P.; Belova, E.V.; Yamada, M.; Ji, H.; Ren, Y.; McGeehan, B.; Inomoto, M.

2008-01-01

A new field-reversed configuration (FRC) formation technique is described, where a spheromak transitions to a FRC with inductive current drive. The transition is accomplished only in argon and krypton plasmas, where low-n kink modes are suppressed; spheromaks with a lighter majority species, such as neon and helium, either display a terminal tilt-mode, or an n=2 kink instability, both resulting in discharge termination. The stability of argon and krypton plasmas through the transition is attributed to the rapid magnetic diffusion of the currents that drive the kink-instability. The decay of helicity during the transition is consistent with that expected from resistivity. This observation indicates a new scheme to form a FRC plasma, provided stability to low-n modes is maintained, as well as a unique situation where the FRC is a preferred state

Heat loss by helicity injection in spheromaks

International Nuclear Information System (INIS)

Fowler, T.K.

1994-01-01

A model is presented for spheromak buildup and decay including thermal diffusivity associated with magnetic turbulence during helicity injection. It is shown that heat loss by magnetic turbulence scales more favorably than gyroBohm transport. Thus gyroBohm scaling for the proposed ignition experiment would be the conservative choice, though present experiments may be dominated by magnetic turbulence. Because of a change in boundary conditions when the gun is turned off, the model may account for the observed increase in electron temperature in CTX after turnoff

CDX2 expression is concordant between primary colorectal cancer lesions and corresponding liver metastases independent of chemotherapy: a single-center retrospective study in Japan.

Science.gov (United States)

Shigematsu, Yasuyuki; Inamura, Kentaro; Mise, Yoshihiro; Saiura, Akio; Rehnberg, Emil; Yamamoto, Noriko; Ishikawa, Yuichi; Takahashi, Shunji; Kanda, Hiroaki

2018-03-30

Loss of caudal-type homeobox transcription factor 2 (CDX2) expression in colorectal cancers (CRCs) has recently been proposed as a promising predictive biomarker for not only prognosis but also response to chemotherapy. However, the relationship between alterations in CDX2 expression during cancer progression and response to chemotherapy remains unclear. We herein aimed to determine the concordance of CDX2 expression between primary CRCs and corresponding liver metastases, in association with chemotherapy. Primary CRCs exhibited heterogeneous CDX2 expression. Seven of the 144 CRCs in the cohort (4.9%, 95% confidential interval, 2.0%-9.8%) were CDX2-negative. The concordance rate of the CDX2 expression status in patients who did not receive chemotherapy was 100% ( P = 0.041), whereas the concordance rate among patients who received chemotherapy only after primary resection was 96.3% ( P = 0.005). Moreover, the concordance rate in patients who received chemotherapy before both primary resection and liver metastasectomy was 100% ( P < 0.001). CDX2 expression status was highly concordant between primary CRCs and corresponding liver metastases, independent of chemotherapy, suggesting that the CDX2 expression status in CRCs was not affected by metastasis or chemotherapy. A total of 144 consecutive patients with CRC who were treated at a single center in Japan between 2006 and 2014 were included. Formalin-fixed paraffin-embedded whole sections of surgically resected primary CRCs and corresponding liver metastases were assessed for CDX2 expression by immunohistochemistry.

Experiments of spheromak and reversed field configuration in 2m theta pinch

International Nuclear Information System (INIS)

Nogi, Y.; Shimamura, S.; Ogura, H.; Osanai, Y.; Saito, K.; Shiina, S.; Yoshimura, H.

1981-01-01

Since the z-current produces the paramagnetic field near the electrodes, the spheromak formation is more difficult in the straight bias field. In order to help the reconnection at the coil ends, the cusp bias coils are added to both ends of the straight coil. Then the spheromak configuration is formed and the plasma is confined for 5 to 10 μs. On the other hand, the RFC continues for about 30 μs in case of the straight bias field. The confinement time is limited by the rotational instability. Although the start time of the instability is not clear, the elongation of the plasma is detected in 15 to 20 μs after the RFC is formed. The period of the rotation is slightly different every shot. Detailed study of the instability is being pursued

Regulation of Laminin γ2 Expression by CDX2 in Colonic Epithelial Cells Is Impaired During Active Inflammation

DEFF Research Database (Denmark)

Coskun, Mehmet; Soendergaard, Christoffer; Jørgensen, Steffen

2017-01-01

and to assess the influence of inflammation. Transcriptional regulation of LAMC2 was examined by reporter gene assays, overexpression, and shRNA-mediated knock-down of CDX2. CDX2-DNA interactions were assessed by chromatin immunoprecipitation on Caco-2 cells without or with TNF-α, as well as in purified colonic......The expression of Caudal-related homeobox transcription factor 2 (CDX2) is impaired by tumor necrosis factor-α (TNF-α)-mediated activation of nuclear factor-κB (NF-κB) in ulcerative colitis (UC). Laminin subunit γ2 (LAMC2) is an epithelial basement membrane protein implicated in cell migration......, proliferation, differentiation, as well as tumor invasion and intestinal inflammation, and its expression is enhanced by TNF-α in a NF-κB-dependent regulation of the recently identified LAMC2 enhancer. The aim was to determine whether CDX2 is involved in the basal regulation of LAMC2 in epithelial cells...

An integrated model of multiple-condition ChIP-Seq data reveals predeterminants of Cdx2 binding.

Directory of Open Access Journals (Sweden)

Shaun Mahony

2014-03-01

Full Text Available Regulatory proteins can bind to different sets of genomic targets in various cell types or conditions. To reliably characterize such condition-specific regulatory binding we introduce MultiGPS, an integrated machine learning approach for the analysis of multiple related ChIP-seq experiments. MultiGPS is based on a generalized Expectation Maximization framework that shares information across multiple experiments for binding event discovery. We demonstrate that our framework enables the simultaneous modeling of sparse condition-specific binding changes, sequence dependence, and replicate-specific noise sources. MultiGPS encourages consistency in reported binding event locations across multiple-condition ChIP-seq datasets and provides accurate estimation of ChIP enrichment levels at each event. MultiGPS's multi-experiment modeling approach thus provides a reliable platform for detecting differential binding enrichment across experimental conditions. We demonstrate the advantages of MultiGPS with an analysis of Cdx2 binding in three distinct developmental contexts. By accurately characterizing condition-specific Cdx2 binding, MultiGPS enables novel insight into the mechanistic basis of Cdx2 site selectivity. Specifically, the condition-specific Cdx2 sites characterized by MultiGPS are highly associated with pre-existing genomic context, suggesting that such sites are pre-determined by cell-specific regulatory architecture. However, MultiGPS-defined condition-independent sites are not predicted by pre-existing regulatory signals, suggesting that Cdx2 can bind to a subset of locations regardless of genomic environment. A summary of this paper appears in the proceedings of the RECOMB 2014 conference, April 2-5.

Cdx2 Polymorphism Affects the Activities of Vitamin D Receptor in Human Breast Cancer Cell Lines and Human Breast Carcinomas

Science.gov (United States)

Di Benedetto, Anna; Korita, Etleva; Goeman, Frauke; Sacconi, Andrea; Biagioni, Francesca; Blandino, Giovanni; Strano, Sabrina; Muti, Paola; Mottolese, Marcella; Falvo, Elisabetta

2015-01-01

Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). It regulates the action of hormone responsive genes and is involved in cell cycle regulation, differentiation and apoptosis. VDR is a critical component of the vitamin D pathway and different common single nucleotide polymorphisms have been identified. Cdx2 VDR polymorphism can play an important role in breast cancer, modulating the activity of VDR. The objective of this study is to assess the relationship between the Cdx2 VDR polymorphism and the activities of VDR in human breast cancer cell lines and carcinomas breast patients. Cdx2 VDR polymorphism and antiproliferative effects of vitamin D treatment were investigated in a panel of estrogen receptor-positive (MCF7 and T-47D) and estrogen receptor-negative (MDA-MB-231, SUM 159PT, SK-BR-3, BT549, MDA-MB-468, HCC1143, BT20 and HCC1954) human breast cancer cell lines. Furthermore, the potential relationship among Cdx2 VDR polymorphism and a number of biomarkers used in clinical management of breast cancer was assessed in an ad hoc set of breast cancer cases. Vitamin D treatment efficacy was found to be strongly dependent on the Cdx2 VDR status in ER-negative breast cancer cell lines tested. In our series of breast cancer cases, the results indicated that patients with variant homozygote AA were associated with bio-pathological characteristics typical of more aggressive tumours, such as ER negative, HER2 positive and G3. Our results may suggest a potential effect of Cdx2 VDR polymorphism on the efficacy of vitamin D treatment in aggressive breast cancer cells (estrogen receptor negative). These results suggest that Cdx2 polymorphism may be a potential biomarker for vitamin D treatment in breast cancer, independently of the VDR receptor expression. PMID:25849303

Cdx2 polymorphism affects the activities of vitamin D receptor in human breast cancer cell lines and human breast carcinomas.

Directory of Open Access Journals (Sweden)

Claudio Pulito

Full Text Available Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR. It regulates the action of hormone responsive genes and is involved in cell cycle regulation, differentiation and apoptosis. VDR is a critical component of the vitamin D pathway and different common single nucleotide polymorphisms have been identified. Cdx2 VDR polymorphism can play an important role in breast cancer, modulating the activity of VDR. The objective of this study is to assess the relationship between the Cdx2 VDR polymorphism and the activities of VDR in human breast cancer cell lines and carcinomas breast patients. Cdx2 VDR polymorphism and antiproliferative effects of vitamin D treatment were investigated in a panel of estrogen receptor-positive (MCF7 and T-47D and estrogen receptor-negative (MDA-MB-231, SUM 159PT, SK-BR-3, BT549, MDA-MB-468, HCC1143, BT20 and HCC1954 human breast cancer cell lines. Furthermore, the potential relationship among Cdx2 VDR polymorphism and a number of biomarkers used in clinical management of breast cancer was assessed in an ad hoc set of breast cancer cases. Vitamin D treatment efficacy was found to be strongly dependent on the Cdx2 VDR status in ER-negative breast cancer cell lines tested. In our series of breast cancer cases, the results indicated that patients with variant homozygote AA were associated with bio-pathological characteristics typical of more aggressive tumours, such as ER negative, HER2 positive and G3. Our results may suggest a potential effect of Cdx2 VDR polymorphism on the efficacy of vitamin D treatment in aggressive breast cancer cells (estrogen receptor negative. These results suggest that Cdx2 polymorphism may be a potential biomarker for vitamin D treatment in breast cancer, independently of the VDR receptor expression.

Simulation study of stepwise relaxation in a spheromak plasma

International Nuclear Information System (INIS)

Horiuchi, Ritoku; Uchida, Masaya; Sato, Tetsuya.

1991-10-01

The energy relaxation process of a spheromak plasma in a flux conserver is investigated by means of a three-dimensional magnetohydrodynamic simulation. The resistive decay of an initial force-free profile brings the spheromak plasma to an m = 1/n = 2 ideal kink unstable region. It is found that the energy relaxation takes place in two steps; namely, the relaxation consists of two physically distinguished phases, and there exists an intermediate phase in between, during which the relaxation becomes inactive temporarily. The first relaxation corresponds to the transition from an axially symmetric force-free state to a helically symmetric one with an n = 2 crescent magnetic island structure via the helical kink instability. The n = 2 helical structure is nonlinearly sustained in the intermediate phase. The helical twisting of the flux tube creates a reconnection current in the vicinity of the geometrical axis. The second relaxation is triggered by the rapid growth of the n = 1 mode when the reconnection current exceeds a critical value. The helical twisting relaxes through magnetic reconnection toward an axially symmetric force-free state. It is also found that the poloidal flux reduces during the helical twisting in the first relaxation and the generation of the toroidal flux occurs through the magnetic reconnection process in the second relaxation. (author)

Prognostic significance of Cdx2 immunohistochemical expression in gastric cancer: a meta-analysis of published literatures

Directory of Open Access Journals (Sweden)

Wang Xiao-Tong

2012-11-01

Full Text Available Abstract Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early intestinal-type gastric cancer. However, its prognostic value and significance in gastric cancer remain controversial. A meta-analysis based on published studies was performed to obtain an accurate evaluation of the association between the presence of Cdx2-positive in clinical samples and clinical outcome. A total of 13 eligible retrospective cohort studies with 1513 patients were included. Cdx2-positive cases were significantly associated with higher male-to-female ratio (RR=1.27, 95% CI: 1.17–1.38, PPP=0.002 fixed-effect and lymph node metastasis (RR=1.52, 95% CI: 1.33-1.73, PP

Expression of an Intestine-Specific Transcription Factor (CDX1) in Intestinal Metaplasia and in Subsequently Developed Intestinal Type of Cholangiocarcinoma in Rat Liver

Science.gov (United States)

Ren, Ping; Silberg, Debra G.; Sirica, Alphonse E.

2000-01-01

CDX1 is a caudal-type homeobox intestine-specific transcription factor that has been shown to be selectively expressed in epithelial cells in intestinal metaplasia of the human stomach and esophagus and variably expressed in human gastric and esophageal adenocarcinomas (Silberg DG, Furth EE, Taylor JK, Schuck T, Chiou T, Traber PG: Gastroenterology 1997, 113: 478–486). Through the use of immunohistochemistry and Western blotting, we investigated whether CDX1 is also uniquely associated with the intestinal metaplasia associated with putative precancerous cholangiofibrosis induced in rat liver during furan cholangiocarcinogenesis, as well as expressed in neoplastic glands in a subsequently developed intestinal type of cholangiocarcinoma. In normal, control adult rat small intestine, specific nuclear immunoreactivity for CDX1 was most prominent in enterocytes lining the crypts. In comparison, epithelium from intestinal metaplastic glands within furan-induced hepatic cholangiofibrosis and neoplastic epithelium from later developed primary intestinal-type cholangiocarcinoma each demonstrated strong nuclear immunoreactivity for CDX1. CDX1-positive cells were detected in hepatic cholangiofibrotic tissue as early as 3 weeks after the start of chronic furan treatment. We further determined that the percentages of CDX1-positive neoplastic glands and glandular nuclei are significantly higher in primary tumors than in a derived, transplantable cholangiocarcinoma serially-propagated in vivo. Western blotting confirmed our immunohistochemical results, and no CDX1 immunoreactivity was detected in normal adult rat liver or in hyperplastic biliary epithelial cells. These findings indicate that CDX1 is specifically associated with early intestinal metaplasia and a later developed intestinal-type of cholangiocarcinoma induced in the liver of furan-treated rats. PMID:10666391

Synthesis and spectroscopic study of high quality alloy Cdx S ...

Indian Academy of Sciences (India)

Wintec

In the present study, we report the synthesis of high quality CdxZn1–xS nanocrystals alloy at. 150°C with .... (XRD) using a Siemens model D 500, powder X-ray ... decays were analysed using IBH DAS6 software. 3. ... This alloying process is.

A spheromak ignition experiment reusing Mirror Fusion Test Facility (MFTF) equipment

International Nuclear Information System (INIS)

Fowler, T.K.

1993-01-01

Based on available experimental results and theory, a scenario is presented to achieve ohmic ignition in a spheromak by slow (∼ 10 sec.) helicity injection using power from the Mirror Fusion Test Facility (MFTF) substation. Some of the other parts needed (vacuum vessel, coils, power supplies, pumps, shielded building space) might also be obtained from MFTF or other salvage, as well as some components needed for intermediate experiments for additional verification of the concept (especially confinement scaling). The proposed ignition experiment would serve as proof-of-principle for the spheromak DT fusion reactor design published by Hagenson and Krakowski, with a nuclear island cost about ten times less than a tokamak of comparable power. Designs at even higher power density and lower cost might be possible using Christofilos' concept of a liquid lithium blanket. Since all structures would be protected from neutrons by the lithium blanket and the tritium inventory can be reduced by continuous removal from the liquid blanket, environmental and safety characteristics appear to be favorable

Magnetic flux conversion and relaxation toward a minimum-energy state in S-1 spheromak plasmas

International Nuclear Information System (INIS)

Janos, A.

1985-09-01

S-1 Spheromak currents and magnetic fluxes have been measured with Rogowski coils and flux loops external to the plasma. Toroidal plasma currents up to 350 kA and spheromak configuration lifetimes over 1.0 msec have been achieved at moderate power levels. The plasma formation in the S-1 Spheromak device is based on an inductive transfer of poloidal and toroidal magnetic flux from a toroidal ''flux core'' to the plasma. Formation is programmed to guide the configuration into a force-free, minimum-energy Taylor state. Properly detailed programming of the formation process is found not to be essential since plasmas adjust themselves during formation to a final equilibrium near the Taylor state. After formation, if the plasma evolves away from the stable state, then distinct relaxation oscillation events occur which restore the configuration to that stable state. The relaxation process involves reconnection of magnetic field lines, and conversion of poloidal to toroidal magnetic flux (and vice versa) has been observed and documented. The scaling of toroidal plasma current and toroidal magnetic flux in the plasma with externally applied currents is consistent with the establishment of a Taylor state after formation. In addition, the magnetic helicity is proportional to that injected from the flux core, independent of how that helicity is generated

Axisymmetric force-free states and relaxation of a spheroidal spheromak

International Nuclear Information System (INIS)

Throumoulopoulos, G.N.; Pantis, G.

1990-01-01

Axisymmetric force-free equilibrium eigenstates for a prolate as well as an oblate spheroidal Spheromak with arbitrary elongation are obtained. In the framework of the Woltjer-Taylor relaxation theory the relaxed states are also identified. A simple hypothesis for the relaxation process is introduced, which implies that the plasma relaxes from multitoroidal formations to a singly toroidal configuration, in qualitative agreement with experimental results. (author)

Axisymmetric force-free states and relaxation of a spheroidal spheromak

International Nuclear Information System (INIS)

Throumoulopoulos, G.N.; Pantis, G.

1990-01-01

Axisymmetric force-free equilibrium eigenstates for a prolate as well as an oblate spheroidal spheromak with arbitrary elongation are obtained. In the framework of the Woltjer-Taylor relaxation theory the relaxed states are also identified. A simple hypothesis for the relaxation process is introduced which implies that the plasma relaxes from multitoroidal formations to a singly toroidal configuration in qualitative agreement with experimental results. (Author)

Nonlinear saturation of non-resonant internal instabilities in a straight spheromak

International Nuclear Information System (INIS)

Park, W.; Jardin, S.C.

1982-04-01

An initial value numerical solution of the time dependent nonlinear ideal magnetohydrodynamic equations demonstrates that spheromak equilibria which are linearly unstable to nonresonant helical internal perturbations saturate at low amplitude without developing singularities. These instabilities thus represent the transition from an axisymmetric to a non-axisymmetric equilibrium state, caused by a peaking of the current density

Current-driven instabilities of the kinetic shear Alfven wave: Application to reversed field pinches and spheromaks

International Nuclear Information System (INIS)

Meyerhofer, D.D.; Perkins, F.W.

1984-01-01

The kinetic Alfven wave is studied in a cylindrical force-free plasma with self-consistent magnetic fields. This equilibrium represents a reversed field pinch or a spheromak. The stability of the wave is found to depend on the ratio of the electron drift velocity to the Alfven velocity. This ratio varies inversely with the square root of the plasma line density. The critical line density using the Spitzer--Harm electron distribution function is found for reversed field pinches with deuterium plasmas to be approximately 2 x 10 18 and is 5 x 10 17 m -1 in spheromaks with hydrogen plasmas. The critical line density is in reasonable agreement with experimental data for reversed field pinches

Current driven instabilities of the kinetic shear Alfven wave: application to reversed field pinches and spheromaks

International Nuclear Information System (INIS)

Meyerhofer, D.D.; Perkins, F.W.

1984-04-01

The kinetic Alfven wave is studied in a cylindrical force-free plasma with self-consistent magnetic fields. This equilibrium represents a reversed field pinch or a spheromak. The stability of the wave is found to depend on the ratio of the electron drift velocity to the Alfven velocity. This ratio varies inversely with the square root of the plasma line density. The critical line density using the Spitzer-Harm electron distribution function is found for reversed field pinches with deuterium plasmas to be approximately 2 x 10 18 m -1 and is 5 x 10 17 m -1 in spheromaks with hydrogen plasmas. The critical line density is in reasonable agreement with experimental data for reversed field pinches

Experimental identification of the kink instability as a poloidal flux amplification mechanism for coaxial gun spheromak formation

International Nuclear Information System (INIS)

Hsu, S.C.; Bellan, P.M.

2003-01-01

The magnetohydrodynamic kink instability is observed and identified experimentally as a poloidal flux amplification mechanism for coaxial gun spheromak formation. Plasmas in this experiment fall into three distinct regimes which depend on the peak gun current to magnetic flux ratio, with (I) low values resulting in a straight plasma column with helical magnetic field, (II) intermediate values leading to kinking of the column axis, and (III) high values leading immediately to a detached plasma. Onset of column kinking agrees quantitatively with the Kruskal-Shafranov limit, and the kink acts as a dynamo which converts toroidal to poloidal flux. Regime II clearly leads to both poloidal flux amplification and the development of a spheromak configuration

Experimental identification of the kink instability as a poloidal flux amplification mechanism for coaxial gun spheromak formation.

Science.gov (United States)

Hsu, S C; Bellan, P M

2003-05-30

The magnetohydrodynamic kink instability is observed and identified experimentally as a poloidal flux amplification mechanism for coaxial gun spheromak formation. Plasmas in this experiment fall into three distinct regimes which depend on the peak gun current to magnetic flux ratio, with (I) low values resulting in a straight plasma column with helical magnetic field, (II) intermediate values leading to kinking of the column axis, and (III) high values leading immediately to a detached plasma. Onset of column kinking agrees quantitatively with the Kruskal-Shafranov limit, and the kink acts as a dynamo which converts toroidal to poloidal flux. Regime II clearly leads to both poloidal flux amplification and the development of a spheromak configuration.

Properties of spheromaks generated by a magnetized coaxial source

International Nuclear Information System (INIS)

Hoida, H.W.; Henins, I.; Jarboe, T.R.; Linford, R.K.; Lipson, J.; Marshall, J.; Platts, D.A.; Sherwood, A.R.; Tuszewski, M.

1981-01-01

In gun-generated spheromaks impurity contamination plays an important role in determining the energy loss. Metallic impurities can be reduced by an appropriate change of source parameters. The reduction of the level of metal impurities results in a spectrum showing a preponderance of oxygen and carbon lines and OIV radiation is observed to increase indicating a warmer plasma. However, the plasma lifetime is not changed. Discharge cleaning techniques appear to be necessary. It is still possible that electron heat conduction during the reconnection processs will be found to be important once the impurities are reduced

Properties of spheromaks generated by a magnetized coaxial source

Energy Technology Data Exchange (ETDEWEB)

Hoida, H.W.; Henins, I.; Jarboe, T.R.; Linford, R.K.; Lipson, J.; Marshall, J.; Platts, D.A.; Sherwood, A.R.; Tuszewski, M.

1981-01-01

In gun-generated spheromaks impurity contamination plays an important role in determining the energy loss. Metallic impurities can be reduced by an appropriate change of source parameters. The reduction of the level of metal impurities results in a spectrum showing a preponderance of oxygen and carbon lines and OIV radiation is observed to increase indicating a warmer plasma. However, the plasma lifetime is not changed. Discharge cleaning techniques appear to be necessary. It is still possible that electron heat conduction during the reconnection processs will be found to be important once the impurities are reduced.

Tearing-mode stability of a forming Spheromak plasma

International Nuclear Information System (INIS)

Heidbrink, W.W.; Jardin, S.C.; Chance, M.S.

1981-10-01

The results of numerical calculations of Δ' for a class of equilibria typical of those encountered during the early formation stage of the S1 Spheromak are presented. The equilibrium plasma is assumed to be cylindrically symmetric and pressureless. It encloses a current carrying perfect conductor (flux core) and is surrounded by a vacuum with zero longitudinal field. Stability boundaries in the space formed by the equilibrium parameters are mapped. The plasma is tearing mode stable provided B/sub z//B/sub theta/ at the flux core is below a certain critical value which depends on the equilibrium parameters. For typical equilibria, this critical value is 0.65

Involvement of CDX2 in the cross talk between TNF-α and Wnt signaling pathway in the colon cancer cell line Caco-2

DEFF Research Database (Denmark)

Coskun, Mehmet; Olsen, Anders Krüger; Bzorek, Michael

2014-01-01

buddings in areas with TNF-α expression in the surrounding inflammatory cells. In vitro studies revealed that TNF-α treatment showed a dose-dependent decrease of CDX2 messenger RNA (mRNA) and protein expression in Caco-2 cells. Inhibition of nuclear factor-kappaB or p38 pathways showed...... targets were significantly elevated in TNF-α-treated Caco-2 cells. These findings were associated with reduced binding of CDX2 to promoter or enhancer regions of APC, AXIN2 and GSK3β. In conclusion, it was found that TNF-α induces the expression of Wnt signaling components through a downregulation......Tumor necrosis factor-α (TNF-α) is highly upregulated in inflammation and reduces the expression of the intestinal transcription factor, Caudal-related homeobox transcription factor 2 (CDX2). Wnt/β-catenin signaling is critical for intestinal cell proliferation, but a decreased CDX2 expression has...

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

Science.gov (United States)

Platet, Nadine; Hinkel, Isabelle; Richert, Ludovic; Murdamoothoo, Devadarssen; Moufok-Sadoun, Ahlam; Vanier, Marie; Lavalle, Philippe; Gaiddon, Christian; Vautier, Dominique; Freund, Jean-Noel; Gross, Isabelle

2017-02-01

The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription factor essential for gut development, acts as a colon-specific tumor suppressor and opposes metastasis. Here, using a combination of biochemical, biophysical, and immunofluorescence techniques, we further investigated the mechanisms promoted by CDX2 that might antagonize tumor cell dissemination. We found that CDX2 expression regulates the transcription of RHO GEFs, thereby activating RHO signaling cascades that lead to reorganization of the actin cytoskeleton and enhanced adherent junctions. Accordingly, we observed by atomic force microscopy (AFM) that colon cancer cells expressing CDX2 are less deformable, a feature that has been shown to correlate with poor metastatic potential. Thus, this study illustrates how the loss of expression of a transcription factor during colon cancer progression modifies the biomechanical characteristics of tumor cells and hence facilitates invasion and metastasis. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The University of Maryland spheromak fusion experiment: Final report

International Nuclear Information System (INIS)

Antoniades, J.A.; Chin-Fatt, C.; DeSilva, A.W.; Goldenbaum, G.C.; Hess, R.A.; Shaw, R.S.

1986-01-01

The spheromak is a magnetic plasma confinement configuration that features a simple magnetic structure free of coils that link the plasma torus. It offers the possibility of a simple and efficient confinement system for a fusion plasma. Design of the experimental apparatus occupied the first 15 months of the contract period. At the same time, computer studies of the formation of the spheromak plasma, using a two-dimensional MHD code were performed. After the first 12 months of the contract period, subcontracts were let for major components of the system, particularly for the liquid nitrogen cooled bias magnetic coils, the associated power supplies, and the capacitors for the reversal bank. When the design work was complete, the machining contract for the vacuum vessel was placed. At about this time, work on the operating system for the control computer was begun. The necessary hardware items for the data acquisition computer were decided upon and ordered at the end of the second year. The capacitor bank for the Z-directed current (I/sub z/ bank) was rebuilt from existing parts here, and construction of this bank and of the parts for the reversal bank was accomplished while the outside fabrication of other major parts was in progress. Switching hardware for the two capacitor banks was fabricated in house to reduce costs. As capacitors for the reversal bank were delivered, they were incorporated into the bank modules. A full description of the MS experimental hardware is described in this paper. 2 refs., 9 figs., 1 tab

First-principles calculations of structural, electronic and optical properties of CdxZn1-xS alloys

KAUST Repository

Noor, Naveed Ahmed

2010-10-01

Structural, electronic and optical properties of ternary alloy system CdxZn1-xS have been studied using first-principles approach based on density functional theory. Electronic structure, density of states and energy band gap values for CdxZn1-xS are estimated in the range 0 ≤ x ≤ 1 using both the standard local density approximation (LDA) as well as the generalized gradient approximations (GGA) of Wu-Cohen (WC) for the exchange-correlation potential. It is observed that the direct band gap EgΓ-Γ of CdxZn1-xS decreases nonlinearly with the compositional parameter x, as observed experimentally. It is also found that Cd s and d, S p and Zn d states play a major role in determining the electronic properties of this alloy system. Furthermore, results for complex dielectric constant ε(ω), refractive index n(ω), normal-incidence reflectivity R(ω), absorption coefficient α(ω) and optical conductivity σ(ω) are also described in a wide range of the incident photon energy and compared with the existing experimental data. © 2010 Elsevier B.V. All rights reserved.

3-D MHD modeling and stability analysis of jet and spheromak plasmas launched into a magnetized plasma

Science.gov (United States)

Fisher, Dustin; Zhang, Yue; Wallace, Ben; Gilmore, Mark; Manchester, Ward; Arge, C. Nick

2016-10-01

The Plasma Bubble Expansion Experiment (PBEX) at the University of New Mexico uses a coaxial plasma gun to launch jet and spheromak magnetic plasma configurations into the Helicon-Cathode (HelCat) plasma device. Plasma structures launched from the gun drag frozen-in magnetic flux into the background magnetic field of the chamber providing a rich set of dynamics to study magnetic turbulence, force-free magnetic spheromaks, and shocks. Preliminary modeling is presented using the highly-developed 3-D, MHD, BATS-R-US code developed at the University of Michigan. BATS-R-US employs an adaptive mesh refinement grid that enables the capture and resolution of shock structures and current sheets, and is particularly suited to model the parameter regime under investigation. CCD images and magnetic field data from the experiment suggest the stabilization of an m =1 kink mode trailing a plasma jet launched into a background magnetic field. Results from a linear stability code investigating the effect of shear-flow as a cause of this stabilization from magnetic tension forces on the jet will be presented. Initial analyses of a possible magnetic Rayleigh Taylor instability seen at the interface between launched spheromaks and their entraining background magnetic field will also be presented. Work supported by the Army Research Office Award No. W911NF1510480.

Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus.

Directory of Open Access Journals (Sweden)

Douglas B Stairs

Full Text Available Barrett's esophagus is a premalignant condition whereby the normal stratified squamous esophageal epithelium undergoes a transdifferentiation program resulting in a simple columnar epithelium reminiscent of the small intestine. These changes are typically associated with the stratified squamous epithelium chronically exposed to acid and bile salts as a result of gastroesophageal reflux disease (GERD. Despite this well-defined epidemiologic association between acid reflux and Barrett's esophagus, the genetic changes that induce this transdifferentiation process in esophageal keratinocytes have remained undefined.To begin to identify the genetic changes responsible for transdifferentiaiton in Barrett's esophagus, we performed a microarray analysis of normal esophageal, Barrett's esophagus and small intestinal biopsy specimens to identify candidate signaling pathways and transcription factors that may be involved. Through this screen we identified the Cdx1 homeodomain transcription factor and the c-myc pathway as possible candidates. Cdx1 and c-myc were then tested for their ability to induce transdifferentiation in immortalized human esophageal keratinocytes using organotypic culturing methods. Analyses of these cultures reveal that c-myc and cdx1 cooperate to induce mucin production and changes in keratin expression that are observed in the epithelium of Barrett's esophagus.These data demonstrate the ability of Cdx1 and c-myc to initiate the earliest stages of transdifferentiation of esophageal keratinocytes toward a cell fate characteristic of Barrett's esophagus.

On the jets, kinks, and spheromaks formed by a planar magnetized coaxial gun

International Nuclear Information System (INIS)

Hsu, S.C.; Bellan, P.M.

2005-01-01

Measurements of the various plasma configurations produced by a planar magnetized coaxial gun provide insight into the magnetic topology evolution resulting from magnetic helicity injection. Important features of the experiments are a very simple coaxial gun design so that all observed geometrical complexity is due to the intrinsic physical dynamics rather than the source shape and use of a fast multiple-frame digital camera which provides direct imaging of topologically complex shapes and dynamics. Three key experimental findings were obtained: (1) formation of an axial collimated jet [Hsu and Bellan, Mon. Not. R. Astron. Soc. 334, 257 (2002)] that is consistent with a magnetohydrodynamic description of astrophysical jets (2) identification of the kink instability when this jet satisfies the Kruskal-Shafranov limit, and (3) the nonlinear properties of the kink instability providing a conversion of toroidal to poloidal flux as required for spheromak formation by a coaxial magnetized source [Hsu and Bellan, Phys. Rev. Lett. 90, 215002 (2003)]. An interpretation is proposed for how the n=1 central column instability provides flux amplification during spheromak formation and sustainment, and it is shown that jet collimation can occur within one rotation of the background poloidal field

NKX2.2, PDX-1 and CDX-2 as potential biomarkers to differentiate well-differentiated neuroendocrine tumors.

Science.gov (United States)

Yang, Michelle X; Coates, Ryan F; Ambaye, Abiy; Cortright, Valerie; Mitchell, Jeannette M; Buskey, Alexa M; Zubarik, Richard; Liu, James G; Ades, Steven; Barry, Maura M

2018-01-01

Well-differentiated neuroendocrine tumors (NET) most frequently arise from the gastrointestinal tract (GI), pancreas, and lung. Patients often present as metastasis with an unknown primary, and the clinical management and outcome depend on multiple factors, including the accurate diagnosis with the tumor primary site. Determining the site of the NET with unknown primary remains challenging. Many biomarkers have been investigated in primary NETs and metastatic NETs, with heterogeneous sensitivity and specificity observed. We used high-throughput tissue microarray (TMA) and immunohistochemistry (IHC) with antibodies against a panel of transcriptional factors including NKX2.2, PDX-1, PTF1A, and CDX-2 on archived formalin-fixed paraffin-embedded NETs, and investigated the protein expression pattern of these transcription factors in 109 primary GI ( N  = 81), pancreatic ( N  = 17), and lung ( N  = 11) NETs. Differential expression pattern of these markers was observed. In the GI and pancreatic NETs ( N  = 98), NKX2.2, PDX-1, and CDX-2 were immunoreactive in 82 (84%), 14 (14%), and 52 (52%) cases, respectively. PDX-1 was expressed mainly in the small intestinal and appendiceal NETs, occasionally in the pancreatic NETs, and not in the colorectal NETs. All three biomarkers including NKX2.2, PDX-1, and CDX-2 were completely negative in lung NETs. PTF1A was expressed in all normal and neuroendocrine tumor cells. Our findings suggest that NKX2.2 was a sensitive and specific biomarker for the GI and pancreatic neuroendocrine tumors. We proposed that a panel of immunostains including NKX2.2, PDX-1, and CDX-2 may show diagnostic utility for the most common NETs.

Roles of CDX2 and EOMES in human induced trophoblast progenitor cells

Energy Technology Data Exchange (ETDEWEB)

Chen, Ying, E-mail: ying.chen@hc.msu.edu [Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503 (United States); Wang, Kai [Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503 (United States); Gong, Yun Guo; Khoo, Sok Kean [Genomic Microarray Core Facility, Van Andel Research Institute, Grand Rapids, MI 49503 (United States); Leach, Richard, E-mail: Richard.Leach@hc.msu.edu [Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503 (United States); Department of Obstetrics, Gynecology and Women’s Health, Spectrum Health Medical Group, Grand Rapids, MI 49503 (United States)

2013-02-08

Highlights: ► CDX2 and EOMES play critical roles in human induced trophoblast progenitors (iTP). ► iTP cells directly transformed from fibroblasts. ► Differentiation of iTP cells into extravillous trophoblasts and syncytiotrophoblasts. -- Abstract: Abnormal trophoblast lineage proliferation and differentiation in early pregnancy have been associated with the pathogenesis of placenta diseases of pregnancy. However, there is still a gap in understanding the molecular mechanisms of early placental development due to the limited primary trophoblast cultures and fidelity of immortalized trophoblast lines. Trophoblasts stem (TS) cells, an in vitro model of trophectoderm that can differentiate into syncytiotrophoblasts and extravillous trophoblasts, can be an attractive tool for early pregnancy research. TS cells are well established in mouse but not in humans due to insufficient knowledge of which trophoblast lineage-specific transcription factors are involved in human trophectoderm (TE) proliferation and differentiation. Here, we applied induced pluripotent stem cell technique to investigate the human trophoblast lineage-specific transcription factors. We established human induced trophoblast progenitor (iTP) cells by direct reprogramming the fibroblasts with a pool of mouse trophoblast lineage-specific transcription factors consisting of CDX2, EOMES, and ELF5. The human iTP cells exhibit epithelial morphology and can be maintained in vitro for more than 2 months. Gene expression profile of these cells was tightly clustered with human trophectoderm but not with human neuron progenitor cells, mesenchymal stem cells, or endoderm cells. These cells are capable of differentiating into cells with an invasive capacity, suggesting extravillous trophoblasts. They also form multi-nucleated cells which secrete human chorionic gonadotropin and estradiol, consistent with a syncytiotrophoblast phenotype. Our results provide the evidence that transcription factors CDX2 and

Two-fluid (plasma-neutral) Extended-MHD simulations of spheromak configurations in the HIT-SI experiment with PSI-Tet

Science.gov (United States)

Sutherland, D. A.; Hansen, C. J.; Jarboe, T. R.

2017-10-01

A self-consistent, two-fluid (plasma-neutral) dynamic neutral model has been implemented into the 3-D, Extended-MHD code PSI-Tet. A monatomic, hydrogenic neutral fluid reacts with a plasma fluid through elastic scattering collisions and three inelastic collision reactions: electron-impact ionization, radiative recombination, and resonant charge-exchange. Density, momentum, and energy are evolved for both the plasma and neutral species. The implemented plasma-neutral model in PSI-Tet is being used to simulate decaying spheromak configurations in the HIT-SI experimental geometry, which is being compare to two-photon absorption laser induced fluorescence measurements (TALIF) made on the HIT-SI3 experiment. TALIF is used to measure the absolute density and temperature of monatomic deuterium atoms. Neutral densities on the order of 1015 m-3 and neutral temperatures between 0.6-1.7 eV were measured towards the end of decay of spheromak configurations with initial toroidal currents between 10-12 kA. Validation results between TALIF measurements and PSI-Tet simulations with the implemented dynamic neutral model will be presented. Additionally, preliminary dynamic neutral simulations of the HIT-SI/HIT-SI3 spheromak plasmas sustained with inductive helicity injection will be presented. Lastly, potential benefits of an expansion of the two-fluid model into a multi-fluid model that includes multiple neutral species and tracking of charge states will be discussed.

Local carbon diffusion coefficient measurement in the S-1 spheromak

International Nuclear Information System (INIS)

Mayo, R.M.; Levinton, F.M.; Meyerhofer, D.D.; Chu, T.K.; Paul, S.F.; Yamada, M.

1988-10-01

The local carbon diffusion coefficient was measured in the S - 1 spheromak by detecting the radial spread of injected carbon impurity. The radial impurity density profile is determined by the balance of ionization and diffusion. Using measured local electron temperature T/sub e/ and density n/sub e/, the ionization rate is determined from which the particle diffusion coefficient is inferred. The results found in this work are consistent with Bohm diffusion. The absolute magnitude of D/sub /perpendicular// was determined to be (4/approximately/6) /times/ D/sub Bohm/. 25 refs., 13 figs., 2 tabs

Growth and characterization of Hg1–xCdxTe epitaxial films by ...

Indian Academy of Sciences (India)

Unknown

Abstract. Growth of Hg1–xCdxTe epitaxial films by a new technique called asymmetric vapour phase epitaxy. (ASVPE) has been carried out on CdTe and CZT substrates. The critical problems faced in normal vapour phase epitaxy technique like poor surface morphology, composition gradient and dislocation multiplication.

Selective decay in a helicity-injected spheromak

International Nuclear Information System (INIS)

MartInez, P L Garcia; Farengo, R

2009-01-01

The non-linear evolution of several unstable equilibria, representative of helicity-injected spheromak configurations inside a cylindrical flux conserver, is studied by means of three dimensional resistive MHD simulations. These equilibria are force-free (∇ x B = λ(ψ)B) but do not correspond to minimum energy states, having linear λ(ψ) profiles with negative slope. Several aspects of this process are studied (magnetic energy relaxation, selective helicity decay, relaxed profiles) for different initial A slopes. The stability threshold predicted by linear theory is recovered. The results show that complete plasma relaxation leading to a uniform A, is achieved only if the initial profile is hollow enough. The evolution for cases just above the stability threshold is more gentle and does not end in a Taylor state. The final state in these cases has a linear λ(ψ) profile, as the initial condition, but with a smaller slope.

Cdx-2 polymorphism in Vitamin D Receptor gene was associated with serum 25-hydroxyvitamin D levels, bone mineral density and fracture in middle-aged and elderly Chinese women.

Science.gov (United States)

Ling, Yan; Lin, Huandong; Aleteng, Qiqige; Ma, Hui; Pan, Baishen; Gao, Jian; Gao, Xin

2016-05-15

The aim of the current study was to examine the relationship between Cdx-2 polymorphism in the promoter region of the VDR gene and serum 25-hydroxyvitamin D (25(OH)D) levels, bone mineral density (BMD) and fracture in Chinese population. This was a cross-sectional study, which included 738 individuals (428 women and 310 men) aged 45 years or older. In women, the association of Cdx-2 polymorphism with serum 25(OH)D levels was significant adjusting for age, BMI, estimated glomerular filtration rate, menopausal status and season of blood collection (P = 0.002). Cdx-2 polymorphism was associated with lumbar spine BMD adjusted for age, BMI, menopausal status and serum 25(OH)D in women (P = 0.005). But it was not associated with femoral neck BMD or total hip BMD in women. In women, Cdx-2 polymorphism was also associated with fracture adjusted for age, BMI, menopausal status, serum 25(OH)D and total hip BMD (P = 0.03). Carriers of AA and AG genotypes was associated with a higher odds of fracture compared with the carriers of GG genotype (OR = 2.14, 95% CI 1.04-4.42 and OR = 1.90, 95% CI 1.03-3.51). In men, Cdx-2 polymorphism was not associated with serum 25(OH)D levels, BMD or fracture. Our results indicate that the association of Cdx-2 polymorphism in the VDR gene with serum 25(OH)D levels, BMD and fracture may have sex differences. Cdx-2 polymorphism in the VDR gene may affect the serum 25(OH)D concentrations and the risk of osteoporosis and fracture in middle-aged and elderly Chinese women. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The Structural, Dielectric, Lattice Dynamical and Thermodynamic Properties of Zinc-Blende CdX (X=S, Se, Te) from First-Principles Analysis

International Nuclear Information System (INIS)

Feng Shi-Quan; Li Jun-Yu; Cheng Xin-Lu

2015-01-01

The structural, dielectric, lattice dynamical and thermodynamic properties of zinc-blende CdX (X=S, Se, Te) are studied by using a plane-wave pseudopotential method within the density-functional theory. Our calculated lattice constants and bulk modulus are compared with the published experimental and theoretical data. In addition, the Born effective charges, electronic dielectric tensors, phonon frequencies, and longitudinal optical-transverse optical splitting are calculated by the linear-response approach. Some of the characteristics of the phonon-dispersion curves for zinc-blende CdX (X=S, Se, Te) are summarized. What is more, based on the lattice dynamical properties, we investigate the thermodynamic properties of CdX (X=S, Se, Te) and analyze the temperature dependences of the Helmholtz free energy F, the internal energy E, the entropy S and the constant-volume specific heat C_v. The results show that the heat capacities for CdTe, CdSe, and CdS approach approximately to the Petit-Dulong limit 6R. (paper)

Resistive stability of the cylindrical spheromak

International Nuclear Information System (INIS)

DeLucia, J.; Jardin, S.C.; Glasser, A.H.

1983-11-01

The growth rates for resistive instabilities in a straight circular cylinder with spheromak profiles are computed by using two complementary methods. The first method employs boundary layer analysis and asymptotic matching, most valid for values of the magnetic Reynolds number S greater than or equal to 10 5 . The second method solved the full linearized resistive MHD equations as an initial value problem, utilizing zone packing around the mode rational surface. Resolution requirements limit this to S less than or equal to 10 7 . The results from these two methods agree to better than 1 in 10 3 in the overlap region 10 7 greater than or equal to S greater than or equal to 10 5 . A scan of parameter space reveals that for parabolic q-profiles, the least unstable configurations have q 0 R/a approx. 0.67. The Hall term in Ohm's Law is easily incorporated into both methods. Recalculating the resistive MHD growth rates in the presence of this term shows that the resistive interchange mode is completely stabilized for a large enough value of the ion cyclotron time

Relaxation and particle diffusion in the Proto S-1/C spheromak

International Nuclear Information System (INIS)

Meyerhofer, D.D.

1987-01-01

The relationship between relaxation and particle diffusion in the Proto S-1C spheromak has been studied. The plasma was formed in a magnetic configuration which was not the minimum-energy Taylor state, and went through a period of relaxation before its magnetic configuration was that of the Taylor state. Early in the relaxation phase, the internal and external magnetic fluctuations were correlated and it was found that, at the time of peak amplitude, they had a radial structure of a tearing mode. After the reconnection of these modes, the plasma continued to evolve towards the Taylor state with only small magnetic fluctuations at the center of plasma. The local particle diffusion coefficient was measured in these Proto S-1C discharges, the technique used was to inject a delta-function source of impurities into the plasma and observe the motion of the impurities relative to the flux surface. It was found that, during the decay phase of the spheromak discharge, when the plasma was in a Taylor state, the carbon diffusion coefficient was explained classically. While the plasma was relaxing towards the Taylor state, the diffusion coefficient was 2 ∼ 4a times larger than classical. At this time, the plasma was not yet force-free. This nonclassical diffusion appears to have been caused by v/sub ExB/ velocities due to correlations between the fluctuating electric field and density. Because the v/sub ExB/ velocity acts on all of the plasma species similarly, the anomalous hydrogen-particle diffusion coefficient should have been as large as that of carbon

Theory of edge plasma in a spheromak

International Nuclear Information System (INIS)

Hooper, E.B.

1998-01-01

Properties of the edge plasma in the SSPX spheromak during the plasma formation and sustainment phases are discussed. For the breakdown and formation phase, the main emphasis is on the analysis of possible plasma contamination by impurities from the electrodes of the plasma gun (helicity injector). The issue of an azimuthally uniform breakdown initiation is also discussed. After the plasma settles down in the main vacuum chamber, one has to sustain the current between the electrodes, in order to continuously inject helicity. We discuss properties of the plasma on the field lines intersecting the electrodes. We conclude that the thermal balance of this plasma is maintained by Joule heating competing with parallel heat losses to the electrodes. The resulting plasma temperature is in the range of 15 - 30 eV. Under the expected operational conditions, the ''current'' velocity of the electrons is only slightly below their thermal velocity. Implications of this observation are briefly discussed

Loss of CDX2 Expression and Microsatellite Instability Are Prominent Features of Large Cell Minimally Differentiated Carcinomas of the Colon

Science.gov (United States)

Hinoi, Takao; Tani, Masachika; Lucas, Peter C.; Caca, Karel; Dunn, Rodney L.; Macri¶, Ettore; Loda¶, Massimo; Appelman, Henry D.; Cho, Kathleen R.; Fearon, Eric R.

2001-01-01

Most large bowel cancers are moderately to well-differentiated adenocarcinomas comprised chiefly or entirely of glands lined by tall columnar cells. We have identified a subset of poorly differentiated colon carcinomas with a distinctive histopathological appearance that we term large cell minimally differentiated carcinomas (LCMDCs). These tumors likely include a group of poorly differentiated carcinomas previously described by others as medullary adenocarcinomas. To better understand the pathogenesis of these uncommon neoplasms, we compared molecular features of 15 LCMDCs to those present in 25 differentiated adenocarcinomas (DACs) of the colon. Tumors were examined for alterations commonly seen in typical colorectal carcinomas, including increased p53 and β-catenin immunoreactivity, K-ras gene mutations, microsatellite instability, and loss of heterozygosity of markers on chromosomes 5q, 17p, and 18q. In addition, tumors were evaluated by immunohistochemistry for CDX2, a homeobox protein whose expression in normal adult tissues is restricted to intestinal and colonic epithelium. Markedly reduced or absent CDX2 expression was noted in 13 of 15 (87%) LCMDCs, whereas only 1 of the 25 (4%) DACs showed reduced CDX2 expression (P < 0.001). Nine of 15 (60%) LCMDCs had the high-frequency microsatellite instability phenotype, but only 2 of 25 (8%) DACs had the high-frequency microsatellite instability phenotype (P = 0.002). Our findings provide support for the hypothesis that the molecular pathogenesis of LCMDCs is distinct from that of most DACs. CDX2 alterations and DNA mismatch repair defects have particularly prominent roles in the development of LCMDCs. PMID:11733373

Design of spheromak injector using conical accelerator for large helical device

Energy Technology Data Exchange (ETDEWEB)

Miyazawa, J.; Yamada, H.; Yasui, K.; Kato, S. [National Inst. for Fusion Science, Toki, Gifu (Japan); Fukumoto, N.; Nagata, M.; Uyama, T. [Himeji Inst. of Tech., Hyogo (Japan)

1999-11-01

Optimization of CT injector for LHD has been carried out and conical electrode for adiabatic CT compression is adopted in the design. Point-model of CT acceleration in a co-axial electrode is solved to optimize the electrode geometry and the power supplies. Large acceleration efficiency of 34% is to be obtained with 3.2 m long conical accelerator and 40 kV - 42 kJ power supply. The operation scenario of a CT injector named SPICA mk. I (SPheromak Injector using Conical Accelerator) consisting of 0.8 m conical accelerator is discussed based on this design. (author)

Sustained spheromak coaxial gun operation in the presence of an n=1 magnetic distortion

International Nuclear Information System (INIS)

Holcomb, C.T.; Jarboe, T.R.; Hill, D.N.; Woodruff, S.; Wood, R.D.

2006-01-01

The Sustained Spheromak Physics Experiment (SSPX) [E. B. Hooper, L. D. Pearlstein, and R. H. Bulmer, Nucl. Fusion 39, 863 (1999)] uses a magnetized coaxial gun to form and sustain spheromaks by helicity injection. Internal probes give the magnetic profile within the gun. An analysis of these data show that a number of commonly applied assumptions are not completely correct, and some previously unrecognized processes may be at work. Specifically, the fraction of the available vacuum flux spanning the gun that is stretched out of the gun is variable and not usually 100%. The n=1 mode that is present during sustained discharges has its largest value of δB/B within the gun, so that instantaneously B within the gun is not axisymmetric. By applying a rigid-rotor model to account for the mode, the instantaneous field and current structure within the gun are determined. The current density is also highly nonaxisymmetric and the local value of λ≡μ 0 j parallel /B is not constant, although the global value λ g ≡μ 0 I g /ψ g closely matches that expected by axisymmetric models. The current distribution near the gun muzzle suggests a cross-field current exists, and this is explained as a line-tying reaction to plasma rotation

Local drift parameter, j/n/sub e/ and resistivity anomaly measurements in CTX spheromaks

International Nuclear Information System (INIS)

Hoida, H.W.; Barnes, C.W.; Henins, I.; Jarboe, T.R.; Marklin, G.; Buchenauer, C.J.; Knox, S.O.

1985-01-01

In a spheromak, the magnetic fields confining the plasma are generated primarily by internal currents rather than external coils. In order to provide information on the possible existence of current-driven microinstabilities, localized measurements of the ratio of the drift velocity of the electrons generating the internal current to their thermal velocity, V/sub d//V/sub th/ proportional to j/n/sub e/√T/sub e/ (known as the drift or streaming parameter), and j/n/sub e/ (proportional to V/sub d/) are needed. These microinstabilities are in some theories associated with an increase in the resistivity anomaly factor (eta/eta/sub Spitzer/). We present results on local measurements (at the magnetic axis) of the values of V/sub d//V/sub th/ and eta/eta/sub Spitzer/ by combining data from the spatially-resolved diagnostics employed on the CTX spheromak experiment, coupled with current density profile information from equilibrium measurements. The values of V/sub d//V/sub th/ and j/n/sub e/ appear to be correlated with local variations in eta/eta/sub Spitzer/, and can be changed by varying the plasma density. Data sets are presented for three values of n/sub e/

A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding

Directory of Open Access Journals (Sweden)

Annabelle Lewis

2014-08-01

Full Text Available A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC. The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs16969681, is also associated with CRC susceptibility, conferring ∼20% differential risk in the general population. We hypothesized the underlying cause to be moderate differences in GREM1 expression. We showed that rs16969681 lies in a region of active chromatin with allele- and tissue-specific enhancer activity. The CRC high-risk allele was associated with stronger gene expression, and higher Grem1 mRNA levels increased the intestinal tumor burden in ApcMin mice. The intestine-specific transcription factor CDX2 and Wnt effector TCF7L2 bound near rs16969681, with significantly higher affinity for the risk allele, and CDX2 overexpression in CDX2/GREM1-negative cells caused re-expression of GREM1. rs16969681 influences CRC risk through effects on Wnt-driven GREM1 expression in colorectal tumors.

Magnetohydrodynamic stability of spheromak plasma in spheroidal flux conserver

International Nuclear Information System (INIS)

Kaneko, Shobu; Kamitani, Atsushi.

1985-11-01

The MHD equilibrium configurations of spheromak plasmas in a spheroidal flux conserver are determined by use of a pressure distribution whose derivative dp/dψ vanishes on the magnetic axis, and by use of an optimized distribution. Here p is the pressure and ψ is the flux function. These equilibria are shown to be stable for symmetric modes. The stability for localized modes is investigated by the Mercier criterion. The values of the maximum beta ratio β max are evaluated for both pressure distributions and are shown to become about two times larger by optimization. If the condition, q axis max are found to be less than 30 %. The oblate spheroidal flux conserver is shown to be better than the toroidal conserver with a rectangular cross section from the standpoint of stability. (author)

Confinement and power balance in the S-1 spheromak

Energy Technology Data Exchange (ETDEWEB)

Levinton, F.M.; Meyerhofer, D.D.; Mayo, R.M.; Janos, A.C.; Ono, Y.; Ueda, Y.; Yamada, M.

1989-07-01

The confinement and scaling features of the S-1 spheromak have been investigated using magnetic, spectroscopic, and Thomson scattering data in conjunction with numerical modeling. Results from the multipoint Thomson scattering diagnostic shows that the central beta remains constant (/beta//sub to/ /approximately/ 5%) as the plasma current density increases from 0.68--2.1 MA/m/sup 2/. The density is observed to increase slowly over this range, while the central electron temperature increases much more rapidly. Analysis of the global plasma parameters shows a decrease in the volume average beta and energy confinement as the total current is increased. The power balance has been modeled numerically with a 0-D non-equilibrium time-dependent coronal model and is consistent with the experimental observations. 20 refs., 12 figs., 2 tabs.

Confinement and power balance in the S-1 spheromak

International Nuclear Information System (INIS)

Levinton, F.M.; Meyerhofer, D.D.; Mayo, R.M.; Janos, A.C.; Ono, Y.; Ueda, Y.; Yamada, M.; Rochester Univ., NY; Los Alamos National Lab., NM; Princeton Univ., NJ

1989-07-01

The confinement and scaling features of the S-1 spheromak have been investigated using magnetic, spectroscopic, and Thomson scattering data in conjunction with numerical modeling. Results from the multipoint Thomson scattering diagnostic shows that the central beta remains constant (β to ∼ 5%) as the plasma current density increases from 0.68--2.1 MA/m 2 . The density is observed to increase slowly over this range, while the central electron temperature increases much more rapidly. Analysis of the global plasma parameters shows a decrease in the volume average beta and energy confinement as the total current is increased. The power balance has been modeled numerically with a 0-D non-equilibrium time-dependent coronal model and is consistent with the experimental observations. 20 refs., 12 figs., 2 tabs

Recent results from the Los Alamos CTX spheromak

Energy Technology Data Exchange (ETDEWEB)

Barnes, C.W.; Henins, I.; Hoida, H.W.; Jarboe, T.R.; Knox, S.O.; Linford, R.K.; Platts, D.A.; Sherwood, A.R.

1982-01-01

Continued discharge cleaning, improved vacuum practices, and optimized plasma formation operation have resulted in the Los Alamos CTX spheromak experiment achieving 1 millisecond plasma lifetimes with average temperatures of 20 to 40 eV. Impurity radiation power loss has been reduced significantly and the plasma behavior appears to be dominated by pressure-driven instabilities causing increased particle loss. The major advance in operation has been the use of a constant, uniform background of 5 to 20 mTorr of H/sub 2/ filling the vacuum tank, flux conserver, and plasma source. This fill operation directly reduces the impurities generated in the plasma source, allows operation of the source at parameters resulting in fewer impurities, and provides a neutral source to maintain the density for long lifetimes. In this paper we present data on the improved operation of CTX, and present evidence for its ..beta..-limited operation.

Recent results from the Los Alamos CTX spheromak

International Nuclear Information System (INIS)

Barnes, C.W.; Henins, I.; Hoida, H.W.; Jarboe, T.R.; Knox, S.O.; Linford, R.K.; Platts, D.A.; Sherwood, A.R.

1982-01-01

Continued discharge cleaning, improved vacuum practices, and optimized plasma formation operation have resulted in the Los Alamos CTX spheromak experiment achieving 1 millisecond plasma lifetimes with average temperatures of 20 to 40 eV. Impurity radiation power loss has been reduced significantly and the plasma behavior appears to be dominated by pressure-driven instabilities causing increased particle loss. The major advance in operation has been the use of a constant, uniform background of 5 to 20 mTorr of H 2 filling the vacuum tank, flux conserver, and plasma source. This fill operation directly reduces the impurities generated in the plasma source, allows operation of the source at parameters resulting in fewer impurities, and provides a neutral source to maintain the density for long lifetimes. In this paper we present data on the improved operation of CTX, and present evidence for its β-limited operation

Interface properties of MIS structures based on hetero-epitaxial graded-gap Hg1-xCdxTe with CdTe interlayer created in situ during MBE growth

Science.gov (United States)

Voitsekhovskii, Alexander V.; Nesmelov, Sergey N.; Dzyadukh, Stanislav M.; Varavin, Vasily S.; Dvoretsky, Sergey A.; Mikhailov, Nikolay N.; Yakushev, Maksim V.; Sidorov, Georgy Yu.

2017-11-01

Heterostructures based on n-Hg1-xCdxTe (x = 0.23-0.40) with near-surface graded-gap layers were grown by molecular beam epitaxy on Si (013) substrates. At 77 K, the admittance of the In/Al2O3/Hg1-xCdxTe metal-insulator-semiconductor (MIS) structures with grown in situ CdTe intermediate layer and without such a layer was investigated. It has been established that MIS structures of In/Al2O3/Hg1-xCdxTe with an interlayer of in situ grown CdTe are characterized by the electrical strength of the dielectric and the qualitative interface. The hysteresis of the capacitive characteristics is practically absent within a small range of variation in the bias voltage. The density of fast surface states at the minimum does not exceed 2.2 × 1010 eV-1 cm-2. MIS structures of In/Al2O3/Hg1-xCdxTe without an intermediate layer of CdTe have significantly higher densities of fast and slow surface states, as well as lower values of the differential resistance of the space-charge region in the regime of strong inversion.

Amplification of S-1 Spheromak current by an inductive current transformer

International Nuclear Information System (INIS)

Jardin, S.C.; Janos, A.; Yamada, M.

1985-11-01

We attempt to predict the consequences of adding an inductive current transformer (OH Transformer) to the present S-1 Spheromak experiment. Axisymmetric modeling with only classical dissipation shows an increase of toroidal current and a shrinking and hollowing of the current channel, conserving toroidal flux. These unstable profiles will undergo helical reconnection, conserving helicity K = ∫ A-vector x B-vector d tau while increasing the toroidal flux and decreasing the poloidal flux so that the plasma relaxes toward the Taylor state. This flux rearrangement is modeled by a new current viscosity term in the mean-field Ohm's law which conserves helicity and dissipates energy

Relationship among mismatch repair deficiency, CDX2 loss, p53 and E-cadherin in colon carcinoma and suitability of using a double panel of mismatch repair proteins by immunohistochemistry.

Science.gov (United States)

Sayar, Ilyas; Akbas, Emin Murat; Isik, Arda; Gokce, Aysun; Peker, Kemal; Demirtas, Levent; Gürbüzel, Mehmet

2015-09-01

Biomarkers such as mismatch repair proteins, CDX2, p53, and E-cadherin are blamed for colon cancers, but the relationships of these biomarkers with each other and with pathological risk factors in colon carcinoma are still not clear. The aim of this study was to evaluate the association of these biomarkers with each other by using immunohistochemical staining and to compare their expression with pathological risk factors for colonic adenocarcinoma. We also aimed to study the usability of a double panel of mismatch repair proteins. One hundred and eleven cases with colonic adenocarcinoma were examined. There was a statistically significant relationship between tumor histological differentiation and perineural invasion, vascular invasion, mismatch repair deficiency, p53, CDX2, and E-cadherin (p < 0.05). PMS2 and MSH6 loss covered 100% of cases with mismatch repair deficiency. Mismatch repair deficiency was correlated with CDX2 loss and E-cadherin expression (p < 0.05). It was also observed that cases with PMS2 loss covered all the cases with CDX2 loss. In conclusion, this double panel may be used instead of a quadruple panel for detecting mismatch repair deficiency. Association of CDX2 and PMS2 in the present study is necessary to conduct further genetic and pathological studies focusing on these two markers together.

0-D study of the compression of low temperature spheromaks

International Nuclear Information System (INIS)

Meyerhofer, D.D.; Hulse, R.A.; Zweibel, E.G.

1985-09-01

Compression of low temperature spheromak plasmas has been studied with the aid of a O-D two-fluid computer code. It is found that in a plasma which is radiation dominated, the electron temperature can be increased by up to a factor of seven for a compression of a factor of two, provided the temperature is above some critical value (approx.25eV) and the electron density particle confinement time product n/sub e/tau/sub p/ greater than or equal to 1 x 10 9 s/cm 3 . If the energy balance is dominated by particle confinement losses rather than radiation losses, the effect of compression is to raise the temperature as T/sub e/ approx.C/sup 6/5/, for constant tau/sub p/

Energy conversion and concentration in a high-current gaseous discharge: Dense plasma spheromak in plasma focus experiments

International Nuclear Information System (INIS)

Kukushkin, A.B.; Rantsev-Kartinov, V.A.; Terentiev, A.R.

1995-01-01

Experimental results are presented which verify the possibility of the self-generated transformation of the magnetic field in plasma focus discharges to give a closed, spheromak-like magnetic configuration (SLMC). The energy conversion mechanism suggests a possibility of further concentrating the plasma power density by means of natural compressing the SLMC-trapped plasma by the residual magnetic field of the plasma focus discharge

Verification of the Taylor (minimum energy) state in the S-1 Spheromak

International Nuclear Information System (INIS)

Hart, G.W.; Janos, A.; Meyerhofer, D.D.; Yamada, M.

1985-09-01

Experimental measurements of the equilibrium in the S-1 Spheromak by use of magnetic probes inside the plasma show that the final magnetic equilibrium is one which has relaxed close to the Taylor (minimum-energy) state, even though the plasma is far from that state during formation. The comparison is made by calculating the two-dimensional μ profile of the plasma from the probe data, where μ is defined as μ 0 j/sub parallel//B. Measurements using a triple Langmuir probe provide evidence to support the conclusion that the pressure gradients in the relaxed state are confined to the edge region of the plasma

Tilt and shift mode stability in a spheromak with a flux core

Energy Technology Data Exchange (ETDEWEB)

Finn, J.M.; Jardin, S.C.

1984-07-01

The stability of spheromak equilibria with a flux core, or reversal coil, is studied by means of an ideal MHD code. Results depend critically upon whether the flux hole region (the current free area just inside the separatrix) is treated as perfectly conducting plasma or as vacuum. This indicates that the tilt and shift modes persist as resistive instabilities if they are stable in ideal MHD. Specifically, for nonoptimally shaped equilibria, the flux core must nearly touch the current channel if the flux hole is vacuum, whereas the core may be slightly outside the separatrix if the flux hole has conducting plasma. A larger margin exists for optimally shaped equilibria.

Global magnetic fluctuations in S-1 spheromak plasmas and relaxation toward a minimum-energy state

International Nuclear Information System (INIS)

Janos, A.; Hart, G.W.; Yamada, M.

1986-01-01

Globally coherent modes have been observed during formation in the S-1 Spheromak plasma. These modes play an important role in flux conversion and plasma relaxation toward a minimum-energy state. A significant finding is the temporal progression through the n = 5, 4, 3, 2; m = 1 mode sequence as q rises through rational fractions m/n. Peak amplitudes of the modes relative to the unperturbed field are typically less than 5%, while amplitudes as high as 20% have been observed

The dynomak: An advanced spheromak reactor concept with imposed-dynamo current drive and next-generation nuclear power technologies

Energy Technology Data Exchange (ETDEWEB)

Sutherland, D.A., E-mail: das1990@uw.edu; Jarboe, T.R.; Morgan, K.D.; Pfaff, M.; Lavine, E.S.; Kamikawa, Y.; Hughes, M.; Andrist, P.; Marklin, G.; Nelson, B.A.

2014-04-15

A high-β spheromak reactor concept has been formulated with an estimated overnight capital cost that is competitive with conventional power sources. This reactor concept utilizes recently discovered imposed-dynamo current drive (IDCD) and a molten salt (FLiBe) blanket system for first wall cooling, neutron moderation and tritium breeding. Currently available materials and ITER-developed cryogenic pumping systems were implemented in this concept from the basis of technological feasibility. A tritium breeding ratio (TBR) of greater than 1.1 has been calculated using a Monte Carlo N-Particle (MCNP5) neutron transport simulation. High temperature superconducting tapes (YBCO) were used for the equilibrium coil set, substantially reducing the recirculating power fraction when compared to previous spheromak reactor studies. Using zirconium hydride for neutron shielding, a limiting equilibrium coil lifetime of at least thirty full-power years has been achieved. The primary FLiBe loop was coupled to a supercritical carbon dioxide Brayton cycle due to attractive economics and high thermal efficiencies. With these advancements, an electrical output of 1000 MW from a thermal output of 2486 MW was achieved, yielding an overall plant efficiency of approximately 40%.

Experimental Identification of the Kink Instability as a Poloidal Flux Amplification Mechanism for Coaxial Gun Spheromak Formation

OpenAIRE

Hsu, S. C.; Bellan, P. M.

2003-01-01

The magnetohydrodynamic kink instability is observed and identified experimentally as a poloidal flux amplification mechanism for coaxial gun spheromak formation. Plasmas in this experiment fall into three distinct regimes which depend on the peak gun current to magnetic flux ratio, with (I) low values resulting in a straight plasma column with helical magnetic field, (II) intermediate values leading to kinking of the column axis, and (III) high values leading immediately to a detached plasma...

Magnetohydrodynamic simulation of kink instability and plasma flow during sustainment of a coaxial gun spheromak

International Nuclear Information System (INIS)

Kanki, Takashi; Nagata, Masayoshi; Kagei, Yasuhiro

2010-01-01

Kink instability and the subsequent plasma flow during the sustainment of a coaxial gun spheromak are investigated by three-dimensional nonlinear magnetohydrodynamic simulations. Analysis of the parallel current density λ profile in the central open column revealed that the n = 1 mode structure plays an important role in the relaxation and current drive. The toroidal flow (v t ≈ 37 km/s) is driven by magnetic reconnection occurring as a result of the helical kink distortion of the central open column during repetitive plasmoid ejection and merging. (author)

Dynamics of spheromak-like compact toroids in a drift tube

International Nuclear Information System (INIS)

Suzuki, Y.; Kishimoto, Y.; Hayashi, T.

2001-01-01

In order to supply plasma fuel confined in spheromak-like compact toroids (SCTs) to a fusion device, the SCTs must be successfully guided through a drift tube region, in which they might be influenced by the magnetic field leaking from the fusion device. To reveal the SCT dynamics in a drift tube, MHD numerical simulations, where the SCTs are accelerated in a co-axial perfectly conducting cylinder with an external magnetic field, are carried out. In addition, the effect of an extended central electrode is examined by changing the length of the inner conducting cylinder. It is revealed that the SCT penetration depth is shorter than that estimated from the conventional conducting sphere model and that the SCTs are further decelerated by extending the inner conducting cylinder. These results are consistent with the results of the compact toroid injection experiment performed on the TEXT Upgrade tokamak. Finally, the deceleration mechanism of the SCTs is discussed by comparing the simulation result with the proposed theoretical model. (author)

Expressão de CDX2 e mucinas (MUC1, MUC2, MUC5AC e MUC6 em esôfago de Barrett antes e após fundoplicatura de Nissen Expression of CDX2 and mucins (MUC1, MUC2, MUC5AC and MUC6 in Barrett's esophagus before and after Nissen fundoplication

Directory of Open Access Journals (Sweden)

Luciana Rodrigues de Meirelles

2012-10-01

Full Text Available INTRODUÇÃO: O esôfago de Barrett (EB corresponde à substituição do epitélio escamoso por um do tipo intestinal, em resposta ao refluxo crônico nos pacientes com doença do refluxo gastroesofágico (DRGE. É um importante precursor do adenocarcinoma esofágico. A fundoplicatura de Nissen (FN é uma cirurgia antirrefluxo que visa a reduzir a agressão à mucosa esofágica. Alterações no padrão de expressão imuno-histoquímica de mucinas e de CDX2 no EB antes e depois da FN podem ser úteis na identificação de um padrão de expressão desses marcadores e, eventualmente, na identificação de casos com risco de evolução para malignidade. OBJETIVOS: Avaliar e comparar a imunoexpressão de CDX2 e mucinas no EB de pacientes com DRGE submetidos à FN antes e após a cirurgia. MATERIAIS E MÉTODOS: Estudo retrospectivo de 25 pacientes com diagnóstico de DRGE e EB submetidos à FN, acompanhados por, pelo menos, três anos. Foram feitos análise histológica e estudo imuno-histoquímico das biópsias endoscópicas antes e após a cirurgia, comparando-se a inflamação e a imunoexpressão de MUC1, MUC2, MUC5AC, MUC6 e CDX2. Estimou-se a porcentagem de células com expressão para os marcadores estudados na mucosa de Barrett: 0%-25%, 25%-75% e 75%-100% das células positivas. Foram utilizados os testes de McNemar e Stuart-William e adotou-se o nível de 5% de significância estatística. RESULTADOS E CONCLUSÃO: Não houve diferenças significativas quanto a presença ou intensidade de inflamação, nem da imunoexpressão de mucinas e CDX2 no EB antes e após a FN. O tratamento cirúrgico não influenciou a mudança da expressão dessas glicoproteínas no EB.INTRODUCTION: Barrett´s esophagus (BE is characterized by the exchange of esophageal squamous epithelium for intestinal type in response to chronic reflux in patients with gastroesophageal reflux disease (GERD.It is an important precursor of esophageal adenocarcinoma. Nissen

Properties of arsenic–implanted Hg1-xCdxTe MBE films

Directory of Open Access Journals (Sweden)

Izhnin Igor I.

2017-01-01

Full Text Available Defect structure of arsenic-implanted Hg1-xCdxTe films (x=0.23–0.30 grown with molecular-beam epitaxy on Si substrates was investigated with the use of optical methods and by studying the electrical properties of the films. The structural perfection of the films remained higher after implantation with more energetic arsenic ions (350 keV vs 190 keV. 100%-activation of implanted ions as a result of post-implantation annealing was achieved, as well as the effective removal of radiation-induced donor defects. In some samples, however, activation of acceptor-like defects not related to mercury vacancies as a result of annealing was observed, possibly related to the effect of the substrate.

Formation of Dirac point and the topological surface states inside the strained gap for mixed 3D Hg1-xCdx Te

Science.gov (United States)

Marchewka, Michał

2016-10-01

In this paper the results of the numerical calculation obtained for the three-dimensional (3D) strained Hg1-xCdx Te layers for the x-Cd composition from 0.1 to 0.155 and a different mismatch of the lattice constant are presented. For the investigated region of the Cd composition (x value) the negative energy gap (Eg =Γ8 -Γ6) in the Hg1-xCdx Te is smaller than in the case of pure HgTe which, as it turns out, has a significant influence on the topological surface states (TSS) and the position of the Dirac point. The numerical calculation based on the finite difference method applied for the 8×8 kp model with the in-plane tensile strain for (001) growth oriented structure shows that the Dirac cone inside the induced insulating band gap for non zero of the Cd composition and a bigger strain caused by the bigger lattice mismatch (than for the 3D HgTe TI) can be obtained. It was also shown how different x-Cd compounds move the Dirac cone from the valence band into the band gap. The presented results show that 75 nm wide 3D Hg1-xCdx Te structures with x ≈ 0.155 and 1.6% lattice mismatch make the system a true topological insulator with the dispersion of the topological surface states similar to those ones obtained for the strained CdTe/HgTe QW.

Effect of the helicity injection rate and the Lundquist number on spheromak sustainment

Science.gov (United States)

García-Martínez, Pablo Luis; Lampugnani, Leandro Gabriel; Farengo, Ricardo

2014-12-01

The dynamics of the magnetic relaxation process during the sustainment of spheromak configurations at different helicity injection rates is studied. The three-dimensional activity is recovered using time-dependent resistive magnetohydrodynamic simulations. A cylindrical flux conserver with concentric electrodes is used to model configurations driven by a magnetized coaxial gun. Magnetic helicity is injected by tangential boundary flows. Different regimes of sustainment are identified and characterized in terms of the safety factor profile. The spatial and temporal behavior of fluctuations is described. The dynamo action is shown to be in close agreement with existing experimental data. These results are relevant to the design and operation of helicity injected devices, as well as to basic understanding of the plasma relaxation mechanism in quasi-steady state.

Effect of the helicity injection rate and the Lundquist number on spheromak sustainment

Energy Technology Data Exchange (ETDEWEB)

García-Martínez, Pablo Luis, E-mail: pablogm@cab.cnea.gov.ar [Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and Sede Andina—Universidad Nacional de Río Negro (UNRN), Av. Bustillo 9500, 8400 San Carlos de Bariloche, Río Negro (Argentina); Lampugnani, Leandro Gabriel; Farengo, Ricardo [Instituto Balseiro and Centro Atómico Bariloche (CAB-CNEA), Av. Bustillo 9500, 8400 San Carlos de Bariloche, Río Negro (Argentina)

2014-12-15

The dynamics of the magnetic relaxation process during the sustainment of spheromak configurations at different helicity injection rates is studied. The three-dimensional activity is recovered using time-dependent resistive magnetohydrodynamic simulations. A cylindrical flux conserver with concentric electrodes is used to model configurations driven by a magnetized coaxial gun. Magnetic helicity is injected by tangential boundary flows. Different regimes of sustainment are identified and characterized in terms of the safety factor profile. The spatial and temporal behavior of fluctuations is described. The dynamo action is shown to be in close agreement with existing experimental data. These results are relevant to the design and operation of helicity injected devices, as well as to basic understanding of the plasma relaxation mechanism in quasi-steady state.

Transport and fluctuations in high temperature spheromak plasmas

International Nuclear Information System (INIS)

McLean, H.S.; Wood, R.D.; Cohen, B.I.; Hooper, E.B.; Hill, D.N.; Moller, J.M.; Romero-Talamas, C.; Woodruff, S.

2006-01-01

Higher electron temperature (T e >350 eV) and reduced electron thermal diffusivity (χ e 2 /s) is achieved in the Sustained Spheromak Physics Experiment (SSPX) by increasing the discharge current=I gun and gun bias flux=ψ gun in a prescribed manner. The internal current and q=safety factor profile derived from equilibrium reconstruction as well as the measured magnetic fluctuation amplitude can be controlled by programming the ratio λ gun =μ 0 I gun /ψ gun . Varying λ gun above and below the minimum energy eigenvalue=λ FC of the flux conserver (∇xB-vector=λ FC B-vector) varies the q profile and produces the m/n=poloidal/toroidal magnetic fluctuation mode spectrum expected from mode-rational surfaces with q=m/n. The highest T e is measured when the gun is driven with λ gun slightly less than λ FC , producing low fluctuation amplitudes ( e as T e increases, differing from Bohm or open field line transport models where χ e increases with T e . Detailed resistive magnetohydrodynamic simulations with the NIMROD code support the analysis of energy confinement in terms of the causal link with the q profile, magnetic fluctuations associated with low-order mode-rational surfaces, and the quality of magnetic surfaces

The impedance of energy efficiency of a coaxial magnetized plasma source used for spheromak formation and sustainment

International Nuclear Information System (INIS)

Barnes, C.W.; Jarboe, T.R.; Marklin, G.J.; Knox, S.O.; Henins, I.

1989-01-01

Electrostatic (dc) helicity injection has previously been shown to successfully sustain the magnetic fields of spheromaks and tokamaks. The magnitude of the injected magnetic helicity balances (within experimental error) the flux lost be resistive decay of the toroidal equilibrium. The problem of optimizing this current drive scheme hence involves maximizing the injected helicity (the voltage-connecting-flux product) while minimizing the current (which multiplied by the voltage represents the energy input and also possible damage to the electrodes). The impedance (voltage-to-current ratio) and energy efficiency of a dc helicity injection experiment are studied on the CTX spheromak. Over several years changes were made in the physical geometry of the coaxial magnetized plasmas source as well as changes in the external electrical circuit. The source could be operated over a wide range of external charging voltage (and hence current), applied axial flux, and source gas flow rate. A database of resulting voltage, helicity injection, efficiency, electron density, and rotation has been created. These experimental results are compared to an ideal magnetohydrodynamic theory of magnetic flux flow. The theory is parameterized by the dimensionless Hall parameter, the ratio of electric to mass current. For a constant Hall parameter the theory explains why the voltage depends quadratically on the current at constant flux. The theory also explains the approximately linear dependence of the impedance-to-current ratio on the current-to-flux ratio of the source. 9 refs., 6 figs

Configuration of gun-generated spheromak in effectively closed metal flux conserver

International Nuclear Information System (INIS)

Kato, Yushi; Nishikawa, Masahiro; Honda, Yoshihide; Satomi, Norio; Watanabe, Kenji

1988-01-01

In the CTCC-II spheromak experiment, the gun-generated plasma is confined in a spheroidal aluminum flux conserver (FC) with a choking coil. This coil produces the additional magnetic field to close perfectly all magnetic surfaces into the FC, i.e. the entrance hole for plasma injection is enable to be closed by magnetic field. Hence the plasma is confined in the effectively closed metal FC. In this experiment the average life time is 1.2 msec, and electron density and temperature are n e = 2 x 10 13 /cc, T e = 30 eV, respectively. The configuration with a flux hole region in which the toroidal magnetic field vanishes around the geometrical axis has been observed in the FC. The radius of the flux hole depends on the condition how the external choking field is applied. The flux hole enhances the magnetic shear near the plasma surfaces and, therefore, has a stabilizing effect even without inserting the central conducting pole. (author)

HIFLUX: OBLATE FRCS, DOUBLE HELICES,SPHEROMAKS AND RFPS IN ONE SYSTEM

International Nuclear Information System (INIS)

SCHAFFER, M.J.; BOEDO, J.A.

2003-01-01

OAK-B135 High magnetic flux is required for thermonuclear FRC reactors and, more immediately, to advance the FRC experimental program in general. Oblate FRCs are of special interest because they are predicted to have certain improved MHD stability over elongated FRCs, and oblate FRCs may yield the most compact, magnetically confined fusion reactors. Neither oblate nor high-flux FRCs have been investigated experimentally to date. Our presently proposed technique is to make two high-flux, oppositely-handed plasmas by a pair of large, external, reversed-field pinch (RFP) sources. The plasmas would propagate as two Taylor-relaxed double-helix plasmas, to an oblate main plasma chamber, where they would relax further to a counter-helicity pair of spheromaks, which would finally merge into a single high-flux FRC. A concept for a new experimental facility, HIFLUX, to make and study high-magnetic-flux oblate Field-Reversed Configuration (FRC) plasmas, is described. Similar principles might also enable high flux non-inductive startup of other plasma devices

Magnetohydrodynamic equilibrium and stability of spheromak with spheroidal plasma-vacuum interface

International Nuclear Information System (INIS)

Kaneko, Shobu; Kamitani, Atsushi; Takimoto, Akio.

1985-05-01

The analytic solutions to the Grad-Shafranov equation are obtained for a prolate and an oblate spheroidal plasma by using Hill's vortex model. Effects of a toroidal magnetic field Bsub(phi) on the MHD equilibrium configurations are investigated by using these analytic solutions. When Bsub(phi) is larger than that of the force-free configuration, the spheroidal plasmas in a vacuum magnetic field are shown to be unable in the MHD equilibrium. The several physical quantities on the equilibrium configuration are evaluated. The spheromak plasma is proved to be unstable if dp/d psi not equal 0 and d 2 V/d psi 2 >= 0 on the magnetic axis. Here p is the pressure and V(psi) the volume surrounded by a magnetic surface of psi=const. The equilibrium configurations of the spheroidal plasmas by using Hill's vortex model are shown to satisfy the above conditions, i.e., to be unstable. (author)

Magnetohydrodynamic equilibrium and stability of spheromak with spheroidal plasma-vacuum interface

International Nuclear Information System (INIS)

Kaneko, Shobu; Kamitani, Atsushi; Takimoto, Akio

1985-01-01

The analytic solutions to the Grad-Shafranov equation are obtained for a prolate and an oblate spheroidal plasma by using Hill's vortex model. Effects of a toroidal magnetic field Bsub(phi) on the MHD equilibrium configurations are investigated by using these analytic solutions. When Bsub(phi) is stronger than that of the force-free configuration, the spheroidal plasmas in a vacuum magnetic field are shown to be unable in the MHD equilibrium. The several physical quantities on the equilibrium configuration are evaluated. The spheromak plasma is proved to be unstable if dp/d psi not equal 0 and d 2 V/d psi 2 >= 0 on the magnetic axis. Here p is the pressure and V(psi) the volume surrounded by a magnetic surface of psi = const. The equilibrium configurations of the spheroidal plasmas by using Hill's vortex model are shown to satisfy the above conditions, i.e., to be unstable. (author)

Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells

Energy Technology Data Exchange (ETDEWEB)

Yap, Chui Sun; Sinha, Rohit Anthony [Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, 8, College Road, Singapore 169857 (Singapore); Ota, Sho; Katsuki, Masahito [Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan); Yen, Paul Michael, E-mail: paul.yen@duke-nus.edu.sg [Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, 8, College Road, Singapore 169857 (Singapore)

2013-11-01

Highlights: •Thyroid hormone induces miR-181d expression in human hepatic cells and mouse livers. •Thyroid hormone downregulates CDX2 and SOAT2 (or ACAT2) via miR-181d. •miR-181d reduces cholesterol output from human hepatic cells. -- Abstract: Thyroid hormones (THs) regulate transcription of many metabolic genes in the liver through its nuclear receptors (TRs). Although the molecular mechanisms for positive regulation of hepatic genes by TH are well understood, much less is known about TH-mediated negative regulation. Recently, several nuclear hormone receptors were shown to downregulate gene expression via miRNAs. To further examine the potential role of miRNAs in TH-mediated negative regulation, we used a miRNA microarray to identify miRNAs that were directly regulated by TH in a human hepatic cell line. In our screen, we discovered that miRNA-181d is a novel hepatic miRNA that was regulated by TH in hepatic cell culture and in vivo. Furthermore, we identified and characterized two novel TH-regulated target genes that were downstream of miR-181d signaling: caudal type homeobox 2 (CDX2) and sterol O-acyltransferase 2 (SOAT2 or ACAT2). CDX2, a known positive regulator of hepatocyte differentiation, was regulated by miR-181d and directly activated SOAT2 gene expression. Since SOAT2 is an enzyme that generates cholesteryl esters that are packaged into lipoproteins, our results suggest miR-181d plays a significant role in the negative regulation of key metabolic genes by TH in the liver.

The S-1 Spheromak Control System

International Nuclear Information System (INIS)

Mathe, P.; Mika, R.; Oliaro, G.

1983-01-01

The use of a CAMAC based DEC LSI-11/23 microcomputer to perform all control functions for the S-1 Spheromak is described. The system monitors and controls the three coil systems, Toroidal, Poloidal, and Equilibrium field coils and their associated power sources, the water cooling system, the personnel and machine safety system, the machine and diagnostic timing system and the control room display and operator interface. Future requirements include control of the vacuum system, the gas injection system and interface to the PPPL Data Acquisition System DEC10. The computer is connected to five remotely located CAMAC crates by a fiber-optic serial highway operating at five megahertz. These crates contain interface modules required to control the S-1 experiment. These modules include: D/A and A/D converters, fast transient digitizers, timing modules, temperature sensing modules, CRT alphanumeric display drivers, watchdog timers, and relay and TTL parallel I/O ports. The computer itself resides in crate number0 and consists of an LSI-11/23 with hardware floating post processor, memory management, 256K bytes of memory, four RS-232 serial ports and a 30 megabyte hard disk with a one megabyte floppy disk backup. The majority of software is written in FORTRAN with a few speed critical programs written in PDP-11 MACRO assembly language. The software simulates a sequential state machine which allows easily changeable logic since all logic is represented by standard Boolean Fortran statements. The RSX-11/m operating system allows multiple tasks to be active simultaneously. This provides computing time for operator interactions, editing of critical machine parameters, data analysis and transmission of data to other computers while still maintaining the scan activity which constantly monitors machine parameters

Phosphine-free synthesis of high-quality reverse type-I ZnSe/CdSe core with CdS/CdxZn1 - xS/ZnS multishell nanocrystals and their application for detection of human hepatitis B surface antigen

Science.gov (United States)

Shen, Huaibin; Yuan, Hang; Niu, Jin Zhong; Xu, Shasha; Zhou, Changhua; Ma, Lan; Li, Lin Song

2011-09-01

Highly photoluminescent (PL) reverse type-I ZnSe/CdSe nanocrystals (NCs) and ZnSe/CdSe/CdS/CdxZn1 - xS/ZnS core/multishell NCs were successfully synthesized by a phosphine-free method. By this low-cost, 'green' synthesis route, more than 10 g of high-quality ZnSe/CdSe/CdS/CdxZn1 - xS/ZnS NCs were synthesized in a large scale synthesis. After the overgrowth of a CdS/CdxZn1 - xS/ZnS multishell on ZnSe/CdSe cores, the PL quantum yields (QYs) increased from 28% to 75% along with the stability improvement. An amphiphilic oligomer was used as a surface coating agent to conduct a phase transfer experiment, core/multishell NCs were dissolved in water by such surface modification and the QYs were still kept above 70%. The as-prepared water dispersible ZnSe/CdSe/CdS/CdxZn1 - xS/ZnS core/multishell NCs not only have high fluorescence QYs but also are extremely stable in various physiological conditions. Furthermore, a biosensor system (lateral flow immunoassay system, LFIA) for the detection of human hepatitis B surface antigen (HBsAg) was developed by using this water-soluble core/multishell NCs as a fluorescent label and a nitrocellulose filter membrane for lateral flow. The result showed that such ZnSe/CdSe/CdS/CdxZn1 - xS/ZnS core/multishell NCs were excellent fluorescent labels to detect HBsAg. The sensitivity of HBsAg detection could reach as high as 0.05 ng ml - 1.

Bandgap engineering of Cu2CdxZn1−xSnS4 alloy for photovoltaic applications: A complementary experimental and first-principles study

KAUST Repository

Xiao, Zhen-Yu; Li, Yong-Feng; Yao, Bin; Deng, Rui; Ding, Zhan-Hui; Wu, Tao; Yang, Gang; Li, Chun-Ran; Dong, Zi-Yuan; Liu, Lei; Zhang, Li-Gong; Zhao, Hai-Feng

2013-01-01

We report on bandgap engineering of an emerging photovoltaic material of Cu2CdxZn1-xSnS4 (CCZTS) alloy. CCZTS alloy thin films with different Cd contents and single kesterite phase were fabricated using the sol-gel method. The optical absorption

Three dimensional simulation study of spheromak injection into magnetized plasmas

International Nuclear Information System (INIS)

Suzuki, Y.; Watanabe, T.H.; Sato, T.; Hayashi, T.

2000-01-01

The three dimensional dynamics of a spheromak-like compact toroid (SCT) plasmoid, which is injected into a magnetized target plasma region, is investigated by using MHD numerical simulations. It is found that the process of SCT penetration into this region is much more complicated than that which has been analysed so far by using a conducting sphere (CS) model. The injected SCT suffers from a tilting instability, which grows with a similar timescale to that of the SCT penetration. The instability is accompanied by magnetic reconnection between the SCT magnetic field and the target magnetic field, which disrupts the magnetic configuration of the SCT. Magnetic reconnection plays a role in supplying the high density plasma, initially confined in the SCT magnetic field, to the target region. The penetration depth of the SCT high density plasma is also examined. It is shown to be shorter than that estimated from the CS model. The SCT high density plasma is decelerated mainly by the Lorentz force of the target magnetic field, which includes not only the magnetic pressure force but also the magnetic tension force. Furthermore, by comparing the SCT plasmoid injection with the bare plasmoid injection, magnetic reconnection is considered to relax the magnetic tension force, i.e. the deceleration of the SCT plasmoid. (author)

Performance Projections For The Lithium Tokamak Experiment (LTX)

International Nuclear Information System (INIS)

Majeski, R.L.; Berzak, T.; Gray, R.; Kaita, T.; Kozub, F.; Levinton, D.P.; Lundberg, J.; Manickam, G.V.; Pereverzev, K.; Snieckus, V.; Soukhanovskii, J.; Spaleta, D.; Stotler, T.; Strickler, J.; Timberlake, J.; Zakharov, L.; Zakharov, Y.

2009-01-01

Use of a large-area liquid lithium limiter in the CDX-U tokamak produced the largest relative increase (an enhancement factor of 5-10) in Ohmic tokamak confinement ever observed. The confinement results from CDX-U do not agree with existing scaling laws, and cannot easily be projected to the new lithium tokamak experiment (LTX). Numerical simulations of CDX-U low recycling discharges have now been performed with the ASTRA-ESC code with a special reference transport model suitable for a diffusion-based confinement regime, incorporating boundary conditions for nonrecycling walls, with fueling via edge gas puffing. This model has been successful at reproducing the experimental values of the energy confinement (4-6 ms), loop voltage (<0.5 V), and density for a typical CDX-U lithium discharge. The same transport model has also been used to project the performance of the LTX, in Ohmic operation, or with modest neutral beam injection (NBI). NBI in LTX, with a low recycling wall of liquid lithium, is predicted to result in core electron and ion temperatures of 1-2 keV, and energy confinement times in excess of 50 ms. Finally, the unique design features of LTX are summarized

The PEP-3-KLH (CDX-110) vaccine in glioblastoma multiforme patients

Science.gov (United States)

Heimberger, Amy B.; Sampson, John H

2009-01-01

Conventional therapies for glioblastoma multiforme (GBM) fail to target tumor cells exclusively resulting in non-specific toxicity. Immune targeting of tumor-specific mutations may allow for more precise eradication of neoplastic cells. The epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation that is widely expressed on GBM and other neoplasms and its expression enhances tumorigenicity. This in-frame deletion mutation splits a codon resulting in a novel glycine at the fusion junction producing a tumor-specific epitope target for cellular or humoral immunotherapy. We have previously shown that vaccination with a peptide that spans the EGFRvIII fusion junction (PEPvIII-KLH/CDX-110) is an efficacious immunotherapy in syngeneic murine models. In this review, we summarize our results in GBM patients targeting this mutation in multiple, multi-institutional Phase II immunotherapy trials. These trials demonstrated that a selected population of GBM patients who received the vaccines targeting EGFRvIII had an unexpectedly long survival time. Further therapeutic strategies and potential pitfalls using this approach are discussed. PMID:19591631

Theoretical aspects of the use of pulsed reflectometry in a spheromak plasma

Energy Technology Data Exchange (ETDEWEB)

Cohen, B. J., LLNL

1998-06-11

Pulsed reflectometry using both ordinary (O) and extraordinary (X) modes has the potential of providing time and space-resolved measurements of the electron density, the magnitude of the magnetic field, and the magnetic shear as a function of radius. Such a diagnostic also yields the current profile from the curl of the magnetic field. This research addresses theoretical issues associated with the use of reflectometry in the SSPX spheromak experiment at the Lawrence Livermore National Laboratory. We have extended a reflectometry simulation model to accommodate O and X-mode mixed polarization and linear mode conversion between the two polarizations. A Wentzel-Kramers-Brillouin-Jeffreys (WKBJ) formula for linear mode conversion agrees reasonably well with direct numerical solutions of the wave equation, and we have reconstructed the magnetic pitch-angle profile by matching the results of the WKBJ formula with the mode conversion data observed in simulations using a least-squares determination of coefficients in trial functions for the profile. The reflectometry data also yield information on fluctuations. Instrumental issues, e.g., the effects of microwave mixers and filters on model reflectometry pulses, have been examined to optimize the performance of the reflectometry diagnostics.

A pSMAD/CDX2 Complex Is Essential for the Intestinalization of Epithelial Metaplasia

Directory of Open Access Journals (Sweden)

Luigi Mari

2014-05-01

Full Text Available The molecular mechanisms leading to epithelial metaplasias are poorly understood. Barrett's esophagus is a premalignant metaplastic change of the esophageal epithelium into columnar epithelium, occurring in patients suffering from gastroesophageal reflux disease. Mechanisms behind the development of the intestinal subtype, which is associated with the highest cancer risk, are unclear. In humans, it has been suggested that a nonspecialized columnar metaplasia precedes the development of intestinal metaplasia. Here, we propose that a complex made up of at least two factors needs to be activated simultaneously to drive the expression of intestinal type of genes. Using unique animal models and robust in vitro assays, we show that the nonspecialized columnar metaplasia is a precursor of intestinal metaplasia and that pSMAD/CDX2 interaction is essential for the switch toward an intestinal phenotype.

Magnetic structure in the entrance region of spheromaks sustained by a magnetized coaxial plasma gun under long pulse operation

International Nuclear Information System (INIS)

Amemiya, Naoyuki; Takaichi, Kazuaki; Katsurai, Makoto

1989-01-01

The magnetic structure in coaxial-gun-sustained spheromaks has been investigated. The plasma gun has been operated with a small axial/radial bias magnetic flux as compared to the azimuthal magnetic flux produced by the discharge current. Stronger magnetic field is observed in the entrance region (ER) than in the flux conserver (FC). In both ER and FC, the magnetic structure is nearly axisymmetric. The axial magnetic field in ER is amplified up to about sixteen times as large as the bias magnetic field. This amplification is limited by the drastic change in the magnetic structure, which occurs when the discharge current becomes very large. The magnetic structure before the drastic change is interpreted with the Bessel function model. The μ estimation shows that the magnetic structure is mainly determined by the boundary geometry, not by the external magnetic flux and current. (author)

Formation and sustainment of field reversed configuration (FRC) plasmas by spheromak merging and neutral beam injection

Energy Technology Data Exchange (ETDEWEB)

Yamada, Masaaki [Princeton Plasma Physics Laboratory, Princeton University Princeton, New Jersey USA (United States)

2016-03-25

This paper briefly reviews a compact toroid reactor concept that addresses critical issues for forming, stabilizing and sustaining a field reversed configuration (FRC) with the use of plasma merging, plasma shaping, conducting shells, neutral beam injection (NBI). In this concept, an FRC plasma is generated by the merging of counter-helicity spheromaks produced by inductive discharges and sustained by the use of neutral beam injection (NBI). Plasma shaping, conducting shells, and the NBI would provide stabilization to global MHD modes. Although a specific FRC reactor design is outside the scope of the present paper, an example of a promising FRC reactor program is summarized based on the previously developed SPIRIT (Self-organized Plasmas by Induction, Reconnection and Injection Techniques) concept in order to connect this concept to the recently achieved the High Performance FRC plasmas obtained by Tri Alpha Energy [Binderbauer et al, Phys. Plasmas 22,056110, (2015)]. This paper includes a brief summary of the previous concept paper by M. Yamada et al, Plasma Fusion Res. 2, 004 (2007) and the recent experimental results from MRX.

Metastable phases freezing from melts of reciprocal systems PbX + CdI2=CdX + PbI2 (X=S, Se, Te)

International Nuclear Information System (INIS)

Odin, I.N.; Chukichev, M.V.

2001-01-01

The transformations in the mutual PbX + CdI 2 =CdX + PbI 2 (X=S, Se, Te) systems leading to the crystallization of metastable polytypical modifications of lead iodide in metastable ternary compounds are studied for the first time. Microstructural and X-ray diffraction analyses were conducted. Their phase diagrams were constructed. The luminescence properties of the stable and metastable modifications of the lead iodide and the metastable compound Pb 4 SeI 6 were investigated. The lines 504 and 512 nm are noted in the 2H-PbI 2 cathodoluminescence spectra. The close lines - 508 and 516 nm provide for the 6R-PbI 2 modification. The metastable compound Pb 4 SeI 6 is characterized by the 769 and 868 nm lines [ru

77 FR 39760 - Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To Add...

Science.gov (United States)

2012-07-05

... entities: Argentina, Venezuela, Brazil, Malaysia, Colombia, Hungary, Indonesia, Panama, Peru, South Africa.... 15 U.S.C. 78q-1(b)(3)(F). Though the CDX.EM Contracts are not themselves securities, the safety and...

Visible Spectrometer at the Compact Toroid Injection Experiment, the Sustained Spheromak Plasma Experiment and the Alcator C-Mod Tokamak for Doppler Width and Shift Measurements

Energy Technology Data Exchange (ETDEWEB)

Graf, A; Howard, S; Horton, R; Hwang, D; May, M; Beiersdorfer, P; McLean, H; Terry, J

2006-05-15

A novel Doppler spectrometer is currently being used for ion or neutral velocity and temperature measurements on the Alcator C-Mod Tokamak. The spectrometer has an f/No. of {approx}3.1 and is appropriate for visible light (3500-6700 {angstrom}). The full width at half maximum from a line emitting calibration source has been measured to be as small as 0.4 {angstrom}. The ultimate time resolution is line brightness light limited and on the order of ms. A new photon efficient detector is being used for the setup at C-Mod. Time resolution is achieved by moving the camera during a plasma discharge in a perpendicular direction through the dispersion plane of the spectrometer causing a vertical streaking across the camera face. Initial results from C-Mod as well as previous measurements from the Compact Toroid Injection Experiment (CTIX) and the Sustained Spheromak Plasma Experiment (SSPX) are presented.

Comparison of three sampling instruments, Cytobrush, Curette and OralCDx, for liquid-based cytology of the oral mucosa.

Science.gov (United States)

Reboiras-López, M D; Pérez-Sayáns, M; Somoza-Martín, J M; Antúnez-López, J R; Gándara-Vila, P; Gayoso-Diz, P; Gándara-Rey, J M; García-García, A

2012-01-01

Exfoliative cytology of the oral cavity is a simple and noninvasive technique that permits the study of epithelial cells. Liquid-based cytology is an auxiliary diagnostic tool for improving the specificity and sensitivity of conventional cytology. The objective of our study was to compare the quality of normal oral mucosa cytology samples obtained using three different instruments, Cytobrush®, dermatological curette and Oral CDx® for liquid-based cytology. One hundred four cytological samples of oral cavity were analyzed. Samples were obtained from healthy volunteer subjects using all three instruments. The clinical and demographic variables were age, sex and smoking habits. We analyzed cellularity, quality of the preparation and types of cells in the samples. All preparations showed appropriate preparation quality. In all smears analyzed, cells were distributed uniformly and showed no mucus, bleeding, inflammatory exudate or artifacts. We found no correlation between the average number of cells and the type of instrument. The samples generally consisted of two types of cells: superficial and intermediate. No differences were found among the cytological preparations of these three instruments. We did not observe basal cells in any of the samples analyzed.

Effect of Cd doping on magnetocaloric effect and critical behavior analysis on perovskite Nd1-xCdxMnO3 (x = 0, 0.1, 0.2, 0.3, and 0.4) manganite polycrystals

Science.gov (United States)

Saravanan, C.; Thiyagarajan, R.; Manikandan, K.; Sathiskumar, M.; Kanjariya, P. V.; Bhalodia, J. A.; Arumugam, S.

2017-12-01

We report the doping effect of divalent cation Cd2+ at Nd-site of intermediate bandwidth manganite system NdMnO3 through the temperature- and magnetic field-dependent magnetization measurements. The parent compound shows paramagnetic-antiferromagnetic transition at 56 K, whereas Cd doped samples show the paramagnetic-ferromagnetic transition with fluctuating TC. During this transition, Nd1-xCdxMnO3 (x = 0.1 and 0.2) samples exhibit first order nature, whereas Nd1-xCdxMnO3 (x = 0.3 and 0.4) samples exhibit second order nature. It confirms a crossover from first order transition to second order transition while x = 0.2 to x = 0.3. By having first order transition, x = 0.2 sample exhibits high magnetic entropy change of 3.62 J kg-1 K-1 for the magnetic field change of 5 T out of all compositions. By having second order transitions, x = 0.4 sample exhibits a high relative cooling power of 319.71 J kg-1 for the magnetic field change of 5 T out of all the compositions. The critical behavior of second order transition of x = 0.3 and 0.4 samples has been analyzed using Arrott and Kouvel-Fisher plots. The estimated critical exponents of these samples are nearly matched with the mean free model, which can be explained by the existence of dipole-dipole interaction by the Cd doping which strengthens long range ferromagnetic interactions between the spins.

Interaction of a spheromak-like compact toroid with a high beta spherical tokamak plasma

International Nuclear Information System (INIS)

Hwang, D.Q.; McLean, H.S.; Baker, K.L.; Evans, R.W.; Horton, R.D.; Terry, S.D.; Howard, S.; Schmidt, G.L.

2000-01-01

Recent experiments using accelerated spheromak-like compact toroids (SCTs) to fuel tokamak plasmas have quantified the penetration mechanism in the low beta regime; i.e. external magnetic field pressure dominates plasma thermal pressure. However, fusion reactor designs require high beta plasma and, more importantly, the proper plasma pressure profile. Here, the effect of the plasma pressure profile on SCT penetration, specifically, the effect of diamagnetism, is addressed. It is estimated that magnetic field pressure dominates penetration even up to 50% local beta. The combination of the diamagnetic effect on the toroidal magnetic field and the strong poloidal field at the outer major radius of a spherical tokamak will result in a diamagnetic well in the total magnetic field. Therefore, the spherical tokamak is a good candidate to test the potential trapping of an SCT in a high beta diamagnetic well. The diamagnetic effects of a high beta spherical tokamak discharge (low aspect ratio) are computed. To test the penetration of an SCT into such a diamagnetic well, experiments have been conducted of SCT injection into a vacuum field structure which simulates the diamagnetic field effect of a high beta tokamak. The diamagnetic field gradient length is substantially shorter than that of the toroidal field of the tokamak, and the results show that it can still improve the penetration of the SCT. Finally, analytic results have been used to estimate the effect of plasma pressure on penetration, and the effect of plasma pressure was found to be small in comparison with the magnetic field pressure. The penetration condition for a vacuum field only is reported. To study the diamagnetic effect in a high beta plasma, additional experiments need to be carried out on a high beta spherical tokamak. (author)

Selecting the optimal synthesis parameters of InP/CdxZn1-xSe quantum dots for a hybrid remote phosphor white LED for general lighting applications.

Science.gov (United States)

Ryckaert, Jana; Correia, António; Tessier, Mickael D; Dupont, Dorian; Hens, Zeger; Hanselaer, Peter; Meuret, Youri

2017-11-27

Quantum dots can be used in white LEDs for lighting applications to fill the spectral gaps in the combined emission spectrum of the blue pumping LED and a broad band phosphor, in order to improve the source color rendering properties. Because quantum dots are low scattering materials, their use can also reduce the amount of backscattered light which can increase the overall efficiency of the white LED. The absorption spectrum and narrow emission spectrum of quantum dots can be easily tuned by altering their synthesis parameters. Due to the re-absorption events between the different luminescent materials and the light interaction with the LED package, determining the optimal quantum dot properties is a highly non-trivial task. In this paper we propose a methodology to select the optimal quantum dot to be combined with a broad band phosphor in order to realize a white LED with optimal luminous efficacy and CRI. The methodology is based on accurate and efficient simulations using the extended adding-doubling approach that take into account all the optical interactions. The method is elaborated for the specific case of a hybrid, remote phosphor white LED with YAG:Ce phosphor in combination with InP/CdxZn 1-x Se type quantum dots. The absorption and emission spectrum of the quantum dots are generated in function of three synthesis parameters (core size, shell size and cadmium fraction) by a semi-empirical 'quantum dot model' to include the continuous tunability of these spectra. The sufficiently fast simulations allow to scan the full parameter space consisting of these synthesis parameters and luminescent material concentrations in terms of CRI and efficacy. A conclusive visualization of the final performance allows to make a well-considered trade-off between these performance parameters. For the hybrid white remote phosphor LED with YAG:Ce and InP/CdxZn 1-x Se quantum dots a CRI Ra = 90 (with R9>50) and an overall efficacy of 110 lm/W is found.

Effects of Large Area Liquid Lithium Limiters on Spherical Torus Plasmas

International Nuclear Information System (INIS)

Kaita, R.; Majeski, R.; Boaz, M.; Efthimion, P.; Gettelfinger, G.; Gray, T.; Hoffman, D.; Jardin, S.; Kugel, H.; Marfuta, P.; Munsat, T.; Neumeyer, C.; Raftopoulos, S.; Soukhanovskii, V.; Spaleta, J.; Taylor, G.; Timberlake, J.; Woolley, R.; Zakharov, L.; Finkenthal, M.; Stutman, D.; Delgado-Aparicio, L.; Seraydarian, R.P.; Antar, G.; Doerner, R.; Luckhardt, S.; Baldwin, M.; Conn, R.W.; Maingi, R.; Menon, M.; Causey, R.; Buchenauer, D.; Ulrickson, M.; Jones, B.; Rodgers, D.

2004-01-01

Use of a large-area liquid lithium surface as a first wall has significantly improved the plasma performance in the Current Drive Experiment-Upgrade (CDX-U) at the Princeton Plasma Physics Laboratory. Previous CDX-U experiments with a partially-covered toroidal lithium limiter tray have shown a decrease in impurities and the recycling of hydrogenic species. Improvements in loading techniques have permitted nearly full coverage of the tray surface with liquid lithium. Under these conditions, there was a large drop in the loop voltage needed to sustain the plasma current. The data are consistent with simulations that indicate more stable plasmas having broader current profiles, higher temperatures, and lowered impurities with liquid lithium walls. As further evidence for reduced recycling with a liquid lithium limiter, the gas puffing had to be increased by up to a factor of eight for the same plasma density achieved with an empty toroidal tray limiter

Effects of large area liquid lithium limiters on spherical torus plasmas

International Nuclear Information System (INIS)

Kaita, R.; Majeski, R.; Boaz, M.; Efthimion, P.; Gettelfinger, G.; Gray, T.; Hoffman, D.; Jardin, S.; Kugel, H.; Marfuta, P.; Munsat, T.; Neumeyer, C.; Raftopoulos, S.; Soukhanovskii, V.; Spaleta, J.; Taylor, G.; Timberlake, J.; Woolley, R.; Zakharov, L.; Finkenthal, M.; Stutman, D.; Delgado-Aparicio, L.; Seraydarian, R.P.; Antar, G.; Doerner, R.; Luckhardt, S.; Baldwin, M.; Conn, R.W.; Maingi, R.; Menon, M.; Causey, R.; Buchenauer, D.; Ulrickson, M.; Jones, B.; Rodgers, D.

2005-01-01

Use of a large-area liquid lithium surface as a limiter has significantly improved the plasma performance in the Current Drive Experiment-Upgrade (CDX-U) at the Princeton Plasma Physics Laboratory. Previous CDX-U experiments with a partially-covered toroidal lithium limiter tray have shown a decrease in impurities and the recycling of hydrogenic species. Improvements in loading techniques have permitted nearly full coverage of the tray surface with liquid lithium. Under these conditions, there was a large drop in the loop voltage needed to sustain the plasma current. The data are consistent with simulations that indicate more stable plasmas having broader current profiles, higher temperatures, and lowered impurities with liquid lithium walls. As further evidence for reduced recycling with a liquid lithium limiter, the gas puffing had to be increased by up to a factor of eight for the same plasma density achieved with an empty toroidal tray limiter

Final Technical Report - ''Determining How Magnetic Helicity Injection Really Works''

International Nuclear Information System (INIS)

Paul M. Bellan

2005-01-01

This research program involved direct observation of the complicated plasma dynamics underlying spheromak formation. Spheromaks are self-organizing magnetically dominated plasma configurations which potentially offer a simple, low-cost means for confining the plasma in a controlled thermonuclear fusion reactor. The spheromak source used in these studies was a coaxial co-planar magnetized plasma gun which was specifically designed to have the simplest relevant geometry. The simplicity of the geometry facilitated understanding of the basic physics and minimized confusion that would otherwise have resulted from complexities due to the experimental geometry. The coaxial plasma gun was mounted on one end of a large vacuum tank that had excellent optical access so the spheromak formation process could be tracked in detail using ultra-high speed cameras. The main accomplishments of this research program were (1) obtaining experimental data characterizing the detailed physics underlying spheromak formation and the development of new theoretical models motivated by these observations, (2) determining the relationship between spheromak physics and astrophysical jets, (3) developing a new high-speed camera diagnostic for the SSPX spheromak at the Lawrence Livermore National Lab, and (4) training graduate students and postdoctoral fellows

Energy efficiency of the CTX magnetized coaxial plasma source

International Nuclear Information System (INIS)

Fernandez, J.C.; Barnes, C.W.; Jarboe, T.R.; Knox, S.O.; Platts, D.A.; McKenna, K.F.

1985-01-01

The energy efficiency of the CTX coaxial plasma source in creating spheromaks is determined experimentally to be in agreement with the theoretical prediction of lambda/sub sp//lambda/sub g/, where del x B = lambda/sub sp/ B in the spheromak, and lambda/sub g/ identical with μ 0 I/sub g//phi/sub g/ with I/sub g/ the source current and phi/sub g/ the magnetic flux through either source electrode. This is shown to be equivalent to magnetic helicity conservation. The spheromak impurity radiation was measured using an absolutely calibrated single chord bolometer system. The theoretical efficiency is within the experimental uncertainty of the ratio of spheromak radiated energy to source input energy in a group of ''dirty'' discharges. But the radiation measurement uncertainty is too large to determine whether a substantial part of the excess source energy not used in the production of spheromak magnetic energy is radiated from the spheromak volume

Evaluation of diagnostic ability of CCD digital radiography in the detection of incipient dental caries

International Nuclear Information System (INIS)

Lee, Wan; Lee, Byung Do

2003-01-01

The purpose of this experiment was to evaluate the diagnostic ability of a CCD-based digital system (CDX-2000HQ) in the detection of incipient dental caries. 93 extracted human teeth with sound proximal surfaces and interproximal artificial cavities were radiographed using 4 imaging methods. Automatically processed No.2 Insight film (Eastman Kodak Co., U.S.A.) was used for conventional radiography, scanned images of conventional radiograms for indirect digital radiography were used. For the direct digital radiography, the CDX-2000HQ CCD system (Biomedisys Co. Korea) was used. The subtraction images were made from two direct digital images by Sunny program in the CDX-2000HQ system. Two radiologists and three endodontists examined the presence of lesions using a five-point confidence scale and compared the diagnostic ability by ROC (Receiver Operating Characteristic) analysis and one way ANOVA test. The mean ROC areas of conventional radiography, indirect digital radiography, direct digital radiography, and digital subtraction radiography were 0.9093, 0.9102, 0.9184, and 0.9056, respectively. The diagnostic ability of direct digital radiography was better than the other imaging modalities, but there were no statistical differences among these imaging modalities (p>0.05). These results indicate that new CCD-based digital systems (CDX-2000HQ) have the potential to serve as an alternative to conventional radiography in the detection of incipient dental caries.

Recent progress on the HESS experiment

International Nuclear Information System (INIS)

Mayo, R.M.; Barnes, D.C.; Freeman, B.; Henins, I.; Jarboe, T.R.; Platts, D.

1990-01-01

The new objective of the Los Alamos spheromak program is to assess the use of magnetized plasmas as an energy transfer medium to accelerate material objects to hyper-velocities (approx-gt 20 km/s). In meeting this objective, the authors are committed to the subordinate goals of (1) creating high field, long-lived spheromak discharges, (2) examining the technical feasibility of employing High Explosives (HE) to compress seed spheromaks, and (3) investigate the technical requirements involved in forming spheromaks by Mechanical Helicity Injection (HMI) using HE. This paper describes the recent efforts of the CTR-5, M-4, and M-6 groups at Los Alamos in assessing the feasibility of generating magnetic helicity by mechanical means in the High Explosive Spheromak Source (HESS) experiment

Improvement of tokamak performance by injection of electrons

International Nuclear Information System (INIS)

Ono, Masayuki.

1992-12-01

Concepts for improving tokamak performance by utilizing injection of hot electrons are discussed. Motivation of this paper is to introduce the research work being performed in this area and to refer the interested readers to the literature for more detail. The electron injection based concepts presented here have been developed in the CDX, CCT, and CDX-U tokamak facilities. The following three promising application areas of electron injection are described here: 1. Non-inductive current drive, 2. Plasma preionization for tokamak start-up assist, and 3. Charging-up of tokamak flux surfaces for improved plasma confinement. The main motivation for the dc-helicity injection current drive is in its efficiency that, in theory, is independent of plasma density. This property makes it attractive for driving currents in high density reactor plasmas

Two novel compact toroidal concepts with Stellarator features

International Nuclear Information System (INIS)

Moroz, P.E.

1997-07-01

Two novel compact toroidal concepts are presented. One is the Stellarator-Spheromak (SSP) and another is the Extreme-Low-Aspect-Ratio Stellarator (ELARS). An SSP device represents a hybrid between a spherical stellarator (SS) and a spheromak. This configuration retains the main advantages of spheromaks ans has a potential for improving the spheromak concept regarding its main problems. The MHD equilibrium in an SSP with very high β of the confined plasma is demonstrated. Another concept, ELARS, represents an extreme limit of the SS approach, and considers devices with stellarator features and aspect ratios A ∼ 1. We have succeeded in finding ELARS configurations with extremely compact, modular, and simple design compatible with significant rotational transform, large plasma volume, and good particle transport characteristics

Plasma response to sustainment with imposed-dynamo current drive in HIT-SI and HIT-SI3

Science.gov (United States)

Hossack, A. C.; Jarboe, T. R.; Chandra, R. N.; Morgan, K. D.; Sutherland, D. A.; Penna, J. M.; Everson, C. J.; Nelson, B. A.

2017-07-01

The helicity injected torus—steady inductive (HIT-SI) program studies efficient, steady-state current drive for magnetic confinement plasmas using a novel experimental method. Stable, high-beta spheromaks have been sustained using steady, inductive current drive. Externally induced loop voltage and magnetic flux are oscillated together so that helicity and power injection are always positive, sustaining the edge plasma current indefinitely. Imposed-dynamo current drive (IDCD) theory further shows that the entire plasma current is sustained. The method is ideal for low aspect ratio, toroidal geometries with closed flux surfaces. Experimental studies of spheromak plasmas sustained with IDCD have shown stable magnetic profiles with evidence of pressure confinement. New measurements show coherent motion of a stable spheromak in response to the imposed perturbations. On the original device two helicity injectors were mounted on either side of the spheromak and the injected mode spectrum was predominantly n  =  1. Coherent, rigid motion indicates that the spheromak is stable and a lack of plasma-generated n  =  1 energy indicates that the maximum q is maintained below 1 during sustainment. Results from the HIT-SI3 device are also presented. Three inductive helicity injectors are mounted on one side of the spheromak flux conserver. Varying the relative injector phasing changes the injected mode spectrum which includes n  =  2, 3, and higher modes.

Surface Treatment of a Lithium Limiter for Spherical Torus Plasma Experiments

Energy Technology Data Exchange (ETDEWEB)

Kaita, R.; Majeski, R.; Doerner, R.; Antar, G.; Timberlake, J.; Spaleta, J.; Hoffman, D.; Jones, B.; Munsat, T.; Kugel, H.; Taylor, G.; Stutman, D.; Soukhanovskii, V.; Maingi, R.; Molesa, S.; Efthimion, P.; Menard, J.; Finkenthal, M.; Luckhardt, S.

2001-03-20

The concept of a flowing lithium first wall for a fusion reactor may lead to a significant advance in reactor design, since it could virtually eliminate the concerns with power density and erosion, tritium retention, and cooling associated with solid walls. As part of investigations to determine the feasibility of this approach, plasma interaction questions in a toroidal plasma geometry are being addressed in the Current Drive eXperiment-Upgrade (CDX-U) spherical torus (ST). The first experiments involved a toroidally local lithium limiter (L3). Measurements of pumpout rates indicated that deuterium pumping was greater for the L3 compared to conventional boron carbide limiters. The difference in the pumpout rates between the two limiter types decreased with plasma exposure, but argon glow discharge cleaning was able to restore the pumping effectiveness of the L3. At no point, however, was the extremely low recycling regime reported in previous lithium experiments achieved. This may be due to the much larger lithium surfaces that were exposed to the plasma in the earlier work. The possibility will be studied in the next set of CDX-U experiments, which are to be conducted with a large area, fully toroidal lithium limiter.

Surface Treatment of a Lithium Limiter for Spherical Torus Plasma Experiments

International Nuclear Information System (INIS)

Kaita, R.; Majeski, R.; Doerner, R.; Antar, G.; Timberlake, J.; Spaleta, J.; Hoffman, D.; Jones, B.; Munsat, T.; Kugel, H.; Taylor, G.; Stutman, D.; Soukhanovskii, V.; Maingi, R.; Molesa, S.; Efthimion, P.; Menard, J.; Finkenthal, M.; Luckhardt, S.

2001-01-01

The concept of a flowing lithium first wall for a fusion reactor may lead to a significant advance in reactor design, since it could virtually eliminate the concerns with power density and erosion, tritium retention, and cooling associated with solid walls. As part of investigations to determine the feasibility of this approach, plasma interaction questions in a toroidal plasma geometry are being addressed in the Current Drive eXperiment-Upgrade (CDX-U) spherical torus (ST). The first experiments involved a toroidally local lithium limiter (L3). Measurements of pumpout rates indicated that deuterium pumping was greater for the L3 compared to conventional boron carbide limiters. The difference in the pumpout rates between the two limiter types decreased with plasma exposure, but argon glow discharge cleaning was able to restore the pumping effectiveness of the L3. At no point, however, was the extremely low recycling regime reported in previous lithium experiments achieved. This may be due to the much larger lithium surfaces that were exposed to the plasma in the earlier work. The possibility will be studied in the next set of CDX-U experiments, which are to be conducted with a large area, fully toroidal lithium limiter

Molecular insight into the inclusion of the dietary plant flavonol fisetin and its chromophore within a chemically modified γ-cyclodextrin: Multi-spectroscopic, molecular docking and solubility studies.

Science.gov (United States)

Pahari, Biswapathik; Chakraborty, Sandipan; Sengupta, Pradeep K

2018-09-15

We explored the encapsulation of dietary plant flavonols fisetin and its chromophore 3-hydroxyflavone, within 2-hydroxypropyl-γ-cyclodextrin (HPγ-CDx) nano-cavity in aqueous solution using multi-spectroscopic approaches and molecular docking. Upon addition of HPγ-CDx, dramatic changes occur in the intrinsic 'two color' fluorescence behavior of the fluorophores. This is manifested by significant increase in the steady state fluorescence intensities, anisotropies, average fluorescence lifetimes and rotational correlation times. Furthermore, in the CDx environment, intrinsically achiral flavonols exhibit prominent induced circular dichroism bands. These findings indicate that the flavonol molecules spontaneously enter the relatively hydrophobic, chiral environment of the HPγ-CDx nano-cavities. Molecular docking computations corroborate the spectroscopic findings, and predict selectivity in orientation of the encapsulated flavonols. HPγ-CDx inclusion increases the aqueous solubility of individual flavonols ∼100-1000 times. The present study demonstrates that the hydroxypropyl substituent in γ-CDx controls the inclusion mode of the flavonols, leading to their enhanced solubilization and altered spectral signatures. Copyright © 2018 Elsevier Ltd. All rights reserved.

Reaction kinetics and transformation of carbadox and structurally related compounds with aqueous chlorine.

Science.gov (United States)

Shah, Amisha D; Kim, Jae-Hong; Huang, Ching-Hua

2006-12-01

The potential release of carbadox (CDX), a commonly used antibacterial agent in swine husbandry, into water systems is of a concern due to its carcinogenic and genotoxic effects. Until this study, the reactivity of carbadox (possessing quinoxaline N,N'-dioxide and hydrazone moieties) toward aqueous chlorine has yetto be investigated in depth. Chemical reactivity, reaction kinetics, and transformation pathways of carbadox and structurally related compounds with free chlorine under typical water treatment conditions were determined. This study found that only CDX and desoxycarbadox (DCDX), a main metabolite of CDX with no ring N-oxide groups, react rapidly with free chlorine while other structurally related compounds including olaquindox, quindoxin, quinoxaline N-oxide, quinoxaline, and quinoline N-oxide do not. The reaction kinetics of CDX and DCDX with chlorine are highly pH dependent (e.g., the apparent second-order rate constant, kapp, for CDX ranges from 51.8 to 3.15 x 10(4) M(-1)s(-1) at pH 4-11). The high reactivity of CDX and DCDX to chlorine involves deprotonation of their hydrazone N-H moieties where initial chlorine attack results in a reactive intermediate that is further attacked by nucleophiles in the matrix to yield non-chlorinated, hydroxylated, and larger molecular weight byproducts. All of the CDX's byproducts retain their biologically active N-oxide groups, suggesting that they may remain as active antibacterial agents.

Bandgap engineering of Cu2CdxZn1−xSnS4 alloy for photovoltaic applications: A complementary experimental and first-principles study

KAUST Repository

Xiao, Zhen-Yu

2013-11-11

We report on bandgap engineering of an emerging photovoltaic material of Cu2CdxZn1-xSnS4 (CCZTS) alloy. CCZTS alloy thin films with different Cd contents and single kesterite phase were fabricated using the sol-gel method. The optical absorption measurements indicate that the bandgap of the kesterite CCZTS alloy can be continuously tuned in a range of 1.55-1.09 eV as Cd content varied from x = 0 to 1. Hall effect measurements suggest that the hole concentration of CCZTS films decreases with increasing Cd content. The CCZTS-based solar cell with x = 0.47 demonstrates a power conversion efficiency of 1.2%. Our first-principles calculations based on the hybrid functional method demonstrate that the bandgap of the kesterite CCZTS alloy decreases monotonically with increasing Cd content, supporting the experimental results. Furthermore, Cu2ZnSnS4/Cu 2CdSnS4 interface has a type-I band-alignment with a small valence-band offset, explaining the narrowing of the bandgap of CCZTS as the Cd content increases. Our results suggest that CCZTS alloy is a potentially suitable material to fabricate high-efficiency multi-junction tandem solar cells with different bandgap-tailored absorption layers. © 2013 AIP Publishing LLC.

Current drive by neutral beams, rotating magnetic fields and helicity injection in compact toroids

International Nuclear Information System (INIS)

Farengo, R.; Arista, N.R.; Lifschitz, A.F.; Clemente, R.A.

2003-01-01

The use of neutral beams (NB) for current drive and heating in spheromaks, the relaxed states of flux core spheromaks (FCS) sustained by helicity injection and the effect of ion dynamics on rotating magnetic field (RMF) current drive in spherical tokamaks (ST) are studied. (author)

Appropriate materials and preparation techniques for polycrystalline-thin-film thermophotovoltaic cells

Science.gov (United States)

Dhere, Neelkanth G.

1997-03-01

Polycrystalline-thin-film thermophotovoltaic (TPV) cells have excellent potential for reducing the cost of TPV generators so as to address the hitherto inaccessible and highly competitive markets such as self-powered gas-fired residential warm air furnaces and energy-efficient electric cars, etc. Recent progress in polycrystalline-thin-film solar cells have made it possible to satisfy the diffusion length and intrinsic junction rectification criteria for TPV cells operating at high fluences. Continuous ranges of direct bandgaps of the ternary and pseudoternary compounds such as Hg1-xCdxTe, Pb1-xCdxTe, Hg1-xZnxTe, and Pb1-xZnxS cover the region of interest of 0.50-0.75 eV for efficient TPV conversion. Other ternary and pseudoternary compounds which show direct bandgaps in most of or all of the 0.50-0.75 eV range are Pb1-xZnxTe, Sn1-xCd2xTe2, Pb1-xCdxSe, Pb1-xZnxSe, and Pb1-xCdxS. Hg1-xCdxTe (with x~0.21) has been studied extensively for infrared detectors. PbTe and Pb1-xSnxTe have also been studied for infrared detectors. Not much work has been carried out on Hg1-xZnxTe thin films. Hg1-xCdxTe and Pb1-xCdxTe alloys cover a wide range of cut-off wavelengths from the far infrared to the near visible. Acceptors and donors are introduced in these materials by excess non-metal (Te) and excess metal (Hg and Pb) respectively. Extrinsic acceptor impurities are Cu, Au, and As while and In and Al are donor impurities. Hg1-xCdxTe thin films have been deposited by isothermal vapor-phase epitaxy (VPE), liquid phase epitaxy (LPE), hot-wall metalorganic chemical vapor deposition (MOCVD), electrodeposition, sputtering, molecular beam epitaxy (MBE), laser-assisted evaporation, and vacuum evaporation with or without hot-wall enclosure. The challenge in the preparation of Hg1-xCdxTe is to provide excess mercury incidence rate, to optimize the deposition parameters for enhanced mercury incorporation, and to achieve the requisite stoichiometry, grain size, and doping. MBE and MOCVD

Application of a magnetized coaxial plasma gun for formation of a high-beta field-reversed configuration

Energy Technology Data Exchange (ETDEWEB)

Nishida, T. [College of Science and Technology, Nihon University, 1-8 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan); Kiguchi, T. [College of Science and Technology, Nihon University, 1-8 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan); Asai, T. [College of Science and Technology, Nihon University, 1-8 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan)]. E-mail: asai@phys.cst.nihon-u.ac.jp; Takahashi, T. [College of Science and Technology, Nihon University, 1-8 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan); Matsuzawa, Y. [College of Science and Technology, Nihon University, 1-8 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan); Okano, T. [College of Science and Technology, Nihon University, 1-8 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan); Nogi, Y. [College of Science and Technology, Nihon University, 1-8 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan)

2006-11-15

We have tested a field-reversed configuration (FRC) formation with a spheromak injection for the first time. In this method, initial pre-ionized plasma is injected as a magnetized spheromak-like plasmoid into the discharge chamber prior to main field reversal. The FRC plasma with an electron density of 1.3 x 10{sup 21} m{sup -3}, a separatrix radius of 0.04 m and a plasma length of 0.8 m was produced successfully in initial background plasma of about 1.6 x 10{sup 19} m{sup -3} by spheromak injection. The density is about one third of the conventional formed by the z-ionized method.

Overcoming regulatory challenges in the development of companion diagnostics for monitoring and safety.

Science.gov (United States)

Shimazawa, Rumiko; Ikeda, Masayuki

2016-03-01

Concurrent development and co-approval of a companion diagnostic (CDx) with a corresponding drug is ideal, but often unfeasible. Because of limited exposure to a drug in clinical trials, crucial information on safety is sometimes revealed only after approval. Therefore, a CDx for monitoring/safety is often developed after approval of a corresponding drug. However, regulatory guidance is insufficient if contemporaneous development is not possible, thereby leaving plenty of opportunities for improvement with respect to pharmacovigilance and retrospective validation of the CDx. Furthermore, global harmonization of guidance on how to incorporate new scientific information from retrospective analyses of biomarkers should lead to the establishment of more evidence for the development of CDx for approved drugs.

3D nanospherical CdxZn1-xS/reduced graphene oxide composites with superior photocatalytic activity and photocorrosion resistance

Science.gov (United States)

Huang, Meina; Yu, Jianhua; Deng, Changshun; Huang, Yingheng; Fan, Minguang; Li, Bin; Tong, Zhangfa; Zhang, Feiyue; Dong, Lihui

2016-03-01

Herein, a series of CdxZn1-xS and sulfide/graphene photocatalysts with 3D nanospherical framework have been successfully fabricated by one-pot solvothermal method for the first time. The morphology and structure of samples were confirmed by X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray (EDX) spectrometry, N2 adsorption, Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS) and ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS). The as-prepared samples exhibit excellent photocatalytic activities and photocorrosion resistance in the degradation of dyes under visible light. The Cd0.5Zn0.5S/rGO sample shows the most efficient in the photodegradation of methyl orange (MO). It takes about 30 min for degradation completely. The enhanced photocatalytic activity is mainly attributed to the slow photon enhancement of the 3D structure, and the heterojunction between the 3D nanospherical Cd0.5Zn0.5S solid solutions and a high quality 2D rGO support, which can greatly promote the separation of light-induced electrons and holes. Moreover, the large SBET and extended light absorption range also play an important role for improving the photocatalytic activity. The high photocatalytic stability is due to the successful inhibition of the photocorrosion of Cd0.5Zn0.5S/rGO by forming heterojunction between CdS and ZnS, and transferring the photogenerated electrons of Cd0.5Zn0.5S to rGO. The present work can provide rational design of graphene-based photocatalysts with large contact interface and strong interaction between the composites for other application.

Experiments with Liquid Metal Walls: Status of the Lithium Tokamak Experiment

OpenAIRE

Boyle, Dennis; Gray, Timothy; Granstedt, Erik; Kozub, Thomas; Berzak, Laura; Hammett, Gregory; Kugel, Henry; Leblanc, Benoit; Logan, Nicholas; Jacobson, Craig M.; Lucia, Matthew; Jones, Andrew; Lundberg, Daniel; Timberlake, John; Majeski, Richard

2010-01-01

Liquid metal walls have been proposed to address the first wall challenge for fusion reactors. The Lithium Tokamak Experiment (LTX) at the Princeton Plasma Physics Laboratory (PPPL) is the first magnetic confinement device to have liquid metal plasma-facing components (PFC's) that encloses virtually the entire plasma. In the Current Drive Experiment-Upgrade (CDX-U), a predecessor to LTX at PPPL, the highest improvement in energy confinement ever observed in Ohmically-heated tokamak plasmas wa...

Reduction of plasma density in the Helicity Injected Torus with Steady Inductance experiment by using a helicon pre-ionization source

International Nuclear Information System (INIS)

Hossack, Aaron C.; Jarboe, Thomas R.; Victor, Brian S.; Firman, Taylor; Prager, James R.; Ziemba, Timothy; Wrobel, Jonathan S.

2013-01-01

A helicon based pre-ionization source has been developed and installed on the Helicity Injected Torus with Steady Inductance (HIT-SI) spheromak. The source initiates plasma breakdown by injecting impurity-free, unmagnetized plasma into the HIT-SI confinement volume. Typical helium spheromaks have electron density reduced from (2–3) × 10 19 m −3 to 1 × 10 19 m −3 . Deuterium spheromak formation is possible with density as low as 2 × 10 18 m −3 . The source also enables HIT-SI to be operated with only one helicity injector at injector frequencies above 14.5 kHz. A theory explaining the physical mechanism driving the reduction of breakdown density is presented

Carbon supported Pd-Co-Mo alloy as an alternative to Pt for oxygen reduction in direct ethanol fuel cells

Energy Technology Data Exchange (ETDEWEB)

Rao, Ch. Venkateswara [National Centre for Catalysis Research, Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, TN (India); Viswanathan, B., E-mail: bvnathan@acer.iitm.ernet.i [National Centre for Catalysis Research, Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, TN (India)

2010-03-01

Carbon black (CDX975) supported Pd and Pd-Co-Mo alloy nanoparticles are prepared by the reduction of metal precursors with hydrazine in reverse microemulsion of water/Triton-X-100/propanol-2/cyclohexane. The as-synthesized Pd-Co-Mo/CDX975 is heat treated at 973, 1073 and 1173 K to promote alloy formation. The prepared materials are characterized by powder XRD and EDX. Face-centred cubic structure of Pd is evident from XRD. The chemical composition of the respective elements in the catalysts is evaluated from the EDX analysis and observed that it is in good agreement with initial metal precursor concentrations. Oxygen reduction measurements performed by linear sweep voltammetry indicate the good catalytic activity of Pd-Co-Mo alloys compared to Pd. This is due to the suppression of (hydr)oxy species on Pd surface by the presence of alloying elements, Co and Mo. Among the investigated catalysts, heat-treated Pd-Co-Mo/CDX975 at 973 K exhibited good ORR activity compared to the catalysts heat treated at 1073 and 1173 K. This is due to the small crystallite size and high surface area. Rotating disk electrode (RDE) measurements indicated the comparable ORR activity of heat-treated Pd-Co-Mo/CDX975 at 973 K with that of commercial Pt/C. Kinetic analysis reveals that the ORR on Pd-Co-Mo/CDX975 follows the four-electron pathway leading to water. Moreover, Pd-Co-Mo/CDX975 exhibited substantially higher ethanol tolerance during the ORR than Pt/C. Good dispersion of metallic nanoparticles on the carbon support is observed from HRTEM images. Single-cell direct ethanol fuel cell tests indicated the comparable performance of Pd-Co-Mo/CDX975 with that of commercial Pt/C. Stability under DEFC operating conditions for 50 h indicated the good stability of Pd-Co-Mo/CDX975 compared with that of Pt/C.

Reduction of plasma density in the Helicity Injected Torus with Steady Inductance experiment by using a helicon pre-ionization source

Energy Technology Data Exchange (ETDEWEB)

Hossack, Aaron C.; Jarboe, Thomas R.; Victor, Brian S. [Department of Aeronautics and Astronautics, University of Washington, Seattle, Washington 98195 (United States); Firman, Taylor; Prager, James R.; Ziemba, Timothy [Eagle Harbor Technologies, Inc., 119 W. Denny Way, Suite 210, Seattle, Washington 98119 (United States); Wrobel, Jonathan S. [979B West Moorhead Circle, Boulder, Colorado 80305 (United States)

2013-10-15

A helicon based pre-ionization source has been developed and installed on the Helicity Injected Torus with Steady Inductance (HIT-SI) spheromak. The source initiates plasma breakdown by injecting impurity-free, unmagnetized plasma into the HIT-SI confinement volume. Typical helium spheromaks have electron density reduced from (2–3) × 10{sup 19} m{sup −3} to 1 × 10{sup 19} m{sup −3}. Deuterium spheromak formation is possible with density as low as 2 × 10{sup 18} m{sup −3}. The source also enables HIT-SI to be operated with only one helicity injector at injector frequencies above 14.5 kHz. A theory explaining the physical mechanism driving the reduction of breakdown density is presented.

Progress Towards High Performance, Steady-state Spherical Torus

International Nuclear Information System (INIS)

Ono, M.; Bell, M.G.; Bell, R.E.; Bigelow, T.; Bitter, M.; Blanchard, W.; Boedo, J.; Bourdelle, C.; Bush, C.; Choe, W.; Chrzanowski, J.; Darrow, D.S.; Diem, S.J.; Doerner, R.; Efthimion, P.C.; Ferron, J.R.; Fonck, R.J.; Fredrickson, E.D.; Garstka, G.D.; Gates, D.A.; Gray, T.; Grisham, L.R.; Heidbrink, W.; Hill, K.W.; Hoffman, D.; Jarboe, T.R.; Johnson, D.W.; Kaita, R.; Kaye, S.M.; Kessel, C.; Kim, J.H.; Kissick, M.W.; Kubota, S.; Kugel, H.W.; LeBlanc, B.P.; Lee, K.; Lee, S.G.; Lewicki, B.T.; Luckhardt, S.; Maingi, R.; Majeski, R.; Manickam, J.; Maqueda, R.; Mau, T.K.; Mazzucato, E.; Medley, S.S.; Menard, J.; Mueller, D.; Nelson, B.A.; Neumeyer, C.; Nishino, N.; Ostrander, C.N.; Pacella, D.; Paoletti, F.; Park, H.K.; Park, W.; Paul, S.F.; Peng, Y.-K. M.; Phillips, C.K.; Pinsker, R.; Probert, P.H.; Ramakrishnan, S.; Raman, R.; Redi, M.; Roquemore, A.L.; Rosenberg, A.; Ryan, P.M.; Sabbagh, S.A.; Schaffer, M.; Schooff, R.J.; Seraydarian, R.; Skinner, C.H.; Sontag, A.C.; Soukhanovskii, V.; Spaleta, J.; Stevenson, T.; Stutman, D.; Swain, D.W.; Synakowski, E.; Takase, Y.; Tang, X.; Taylor, G.; Timberlake, J.; Tritz, K.L.; Unterberg, E.A.; Von Halle, A.; Wilgen, J.; Williams, M.; Wilson, J.R.; Xu, X.; Zweben, S.J.; Akers, R.; Barry, R.E.; Beiersdorfer, P.; Bialek, J.M.; Blagojevic, B.; Bonoli, P.T.; Carter, M.D.; Davis, W.; Deng, B.; Dudek, L.; Egedal, J.; Ellis, R.; Finkenthal, M.; Foley, J.; Fredd, E.; Glasser, A.; Gibney, T.; Gilmore, M.; Goldston, R.J.; Hatcher, R.E.; Hawryluk, R.J.; Houlberg, W.; Harvey, R.; Jardin, S.C.; Hosea, J.C.; Ji, H.; Kalish, M.; Lowrance, J.; Lao, L.L.; Levinton, F.M.; Luhmann, N.C.; Marsala, R.; Mastravito, D.; Menon, M.M.; Mitarai, O.; Nagata, M.; Oliaro, G.; Parsells, R.; Peebles, T.; Peneflor, B.; Piglowski, D.; Porter, G.D.; Ram, A.K.; Rensink, M.; Rewoldt, G.; Roney, P.; Shaing, K.; Shiraiwa, S.; Sichta, P.; Stotler, D.; Stratton, B.C.; Vero, R.; Wampler, W.R.; Wurden, G.A.

2003-01-01

Research on the Spherical Torus (or Spherical Tokamak) is being pursued to explore the scientific benefits of modifying the field line structure from that in more moderate aspect-ratio devices, such as the conventional tokamak. The Spherical Tours (ST) experiments are being conducted in various U.S. research facilities including the MA-class National Spherical Torus Experiment (NSTX) at Princeton, and three medium-size ST research facilities: Pegasus at University of Wisconsin, HIT-II at University of Washington, and CDX-U at Princeton. In the context of the fusion energy development path being formulated in the U.S., an ST-based Component Test Facility (CTF) and, ultimately a Demo device, are being discussed. For these, it is essential to develop high-performance, steady-state operational scenarios. The relevant scientific issues are energy confinement, MHD stability at high beta (B), noninductive sustainment, ohmic-solenoid-free start-up, and power and particle handling. In the confinement area, the NSTX experiments have shown that the confinement can be up to 50% better than the ITER-98-pby2 H-mode scaling, consistent with the requirements for an ST-based CTF and Demo. In NSTX, CTF-relevant average toroidal beta values bT of up to 35% with the near unity central betaT have been obtained. NSTX will be exploring advanced regimes where bT up to 40% can be sustained through active stabilization of resistive wall modes. To date, the most successful technique for noninductive sustainment in NSTX is the high beta-poloidal regime, where discharges with a high noninductive fraction (∼60% bootstrap current + neutral-beam-injected current drive) were sustained over the resistive skin time. Research on radio-frequency-based heating and current drive utilizing HHFW (High Harmonic Fast Wave) and EBW (Electron Bernstein Wave) is also pursued on NSTX, Pegasus, and CDX-U. For noninductive start-up, the Coaxial Helicity Injection (CHI), developed in HIT/HIT-II, has been adopted

Particle transport and gas feed during gun injection

International Nuclear Information System (INIS)

Fowler, T K.

1999-01-01

It is shown that ion and neutral transport during gun injection tends to equalize the density in the spheromak to that in the open-line current channel. Since a gun operating at or near the ion saturation current requires a minimum density, because of transport these gun requirements also determine a minimum density in the spheromak that increases as the field increases. Hence attaining high fields by gun injection sets lower limits on the density, which in turn limits the temperature of the plasma and increases its ohmic resistance. Estimates of these effects are given using 0-D models calibrated to CTX, as guidance to 2-D UEDGE calculations in progress. For gun power levels in SSPX and the Pulsed Spheromak reactor, we find that buildup persists to the highest field levels of interest

Enhanced Mode Conversion of Thermally Emitted Electron Bernstein Waves (EBW)to Extraordinary Mode

International Nuclear Information System (INIS)

Jones, B.; Efthimion, P.C.; Taylor, G.; Munsat, T.; Wilson, J.R.; Hosea, J.C.; Kaita, R.; Majeski, R.; Maingi, R.; Shiraiwa, S.; Spaleta, J.

2002-01-01

In the CDX-U spherical torus, approximately 100% conversion of thermal EBWs to X-mode has been observed by controlling the electron density scale length (Ln) in the conversion region with a local limiter outside the last closed flux surface. The radiation temperature profile agrees with Thomson scattering electron temperature data. Results are consistent with theoretical calculations of conversion efficiency using measured Ln. By reciprocity of the conversion process, prospects for efficient coupling in EBW heating and current drive scenarios are strongly supported

Enhanced Mode Conversion of Thermally Emitted Electron Bernstein Waves (EBW)to Extraordinary Mode; TOPICAL

International Nuclear Information System (INIS)

B. Jones; P.C. Efthimion; G. Taylor; T. Munsat; J.R. Wilson; J.C. Hosea; R. Kaita; R. Majeski; R. Maingi; S. Shiraiwa; J. Spaleta

2002-01-01

In the CDX-U spherical torus, approximately 100% conversion of thermal EBWs to X-mode has been observed by controlling the electron density scale length (Ln) in the conversion region with a local limiter outside the last closed flux surface. The radiation temperature profile agrees with Thomson scattering electron temperature data. Results are consistent with theoretical calculations of conversion efficiency using measured Ln. By reciprocity of the conversion process, prospects for efficient coupling in EBW heating and current drive scenarios are strongly supported

Flourimetric and prototropic studies on the inclusion complexation of 2-amino and 4-aminodiphenyl ethers with {beta}-cyclodextrin: Unusual behavior of 4-aminodiphenyl ether

Energy Technology Data Exchange (ETDEWEB)

Enoch, Israel V. Muthu Vijayan [Department of Chemistry, Annamalai University, Annamalainagar 608 002, Tamil Nadu (India); Swaminathan, Meenakshisundaram [Department of Chemistry, Annamalai University, Annamalainagar 608 002, Tamil Nadu (India)], E-mail: chemsam@yahoo.com

2007-12-15

The fluorescence characteristics of diphenyl ether (DPE), 2-aminodiphenyl ether (2ADPE) and 4-aminodiphenyl ether (4ADPE) and prototropic behavior of 2ADPE and 4ADPE on inclusion complexation with {beta}-cyclodextrin have been investigated. DPE forms 1:1 complex whereas 2ADPE and 4ADPE form 1:2 complex with {beta}-CDx. The fluorimetric and prototropic behaviors of 4ADPE in {beta}-CDx are different from those in aqueous solution. The dual fluorescence of 4ADPE in {beta}-CDx is found to be due to twisted intramolecular charge transfer (TICT) character induced by inclusion complexation. The two equilibria viz. monocation{r_reversible}monocation solvent exciplex{r_reversible}neutral reported for 4ADPE in aqueous solution are not observed in presence of {beta}-CDx. The ground and excited state pK{sub a} values for monocation-neutral equilibrium of 2ADPE and 4ADPE have been reported.

GPNMB expression in uveal melanoma: a potential for targeted therapy.

Science.gov (United States)

Williams, Michelle D; Esmaeli, Bita; Soheili, Aydin; Simantov, Ronit; Gombos, Dan S; Bedikian, Agop Y; Hwu, Patrick

2010-06-01

Uveal melanoma is an aggressive disease without effective adjuvant therapy for metastases. Despite genomic differences between cutaneous and uveal melanomas, therapies based on shared biological factors could be effective against both tumor types. High expression of glycoprotein-NMB (GPNMB) in cutaneous melanomas led to the development of CDX-011 (glembatumumab vedotin), a fully human monoclonal antibody against the extracellular domain of GPNMB conjugated to the cytotoxic microtubule toxin monomethylauristatin E. Ongoing phase II trials suggest that CDX-011 has activity against advanced cutaneous melanomas. To determine the potential role of CDX-011 in uveal melanomas, we studied their GPNMB expression. Paraffin-embedded tissues from 22 uveal melanomas treated by enucleation from 2004-2007 at one institution were evaluated immunohistochemically for expression of GPNMB using biotinylated CDX-011 (unconjugated) antibody. Melanoma cells were evaluated for percentage and intensity of expression. Spectral imaging was used in one case with high melanin content. Clinical data were reviewed. Twelve women and 10 men with a median age of 58.7 years (range: 28-83 years) were included. Eighteen of 21 tumors evaluated immunohistochemically (85.7%) expressed GPNMB in 10-90% of tumor cells with variable intensity (5 tumors, 1+; 11, 2+; and 2, 3+). Eleven of 18 tumors (61.1%) expressed GPNMB in >or=50% of cells. Spectral imaging showed diffuse CDX-011 (unconjugated) reactivity in the remaining case. Uveal melanoma, like cutaneous melanoma, commonly expresses GPNMB. Ongoing clinical trials of CDX-011 should be extended to patients with metastatic uveal melanoma to determine potential efficacy in this subset of patients with melanoma.

Improvement in Plasma Performance with Lithium Coatings in NSTX

International Nuclear Information System (INIS)

Kaita, R.

2009-01-01

Lithium as a plasma-facing material has attractive features, including a reduction in the recycling of hydrogenic species and the potential for withstanding high heat and neutron fluxes in fusion reactors. Dramatic effects on plasma performance with lithium-coated plasma-facing components (PFC's) have been demonstrated on many fusion devices, including TFTR, T-11M, and FT-U. Using a liquid-lithium-filled tray as a limiter, the CDX-U device achieved very significant enhancement in the confinement time of ohmically heated plasmas. The recent NSTX experiments reported here have demonstrated, for the first time, significant and recurring benefits of lithium PFC coatings on divertor plasma performance in both L- and H- mode regimes heated by neutral beams.

Meta-analysis of two computer-assisted screening methods for diagnosing oral precancer and cancer.

Science.gov (United States)

Ye, Xiaojing; Zhang, Jing; Tan, Yaqin; Chen, Guanying; Zhou, Gang

2015-11-01

The early diagnosis of oral precancer and cancer is crucial and could have the highest impact on improving survival rates. A meta-analysis was conducted to compare the accuracy between the OralCDx brush biopsy and DNA-image cytometry in diagnosing both conditions. Bibliographic databases were systematically searched for original relevant studies on the early diagnosis of oral precancer and oral cancer. Study characteristics were evaluated to determine the accuracy of the two screening strategies. Thirteen studies (eight of OralCDx brush biopsy and five of DNA-image cytometry) were identified as having reported on 1981 oral mucosa lesions. The meta-analysis found that the area under the summary receiver operating characteristic curves of the OralCDx brush biopsy and DNA-image cytometry were 0.8879 and 0.9885, respectively. The pooled sensitivity, specificity, and diagnostic odds ratio of the OralCDx brush biopsy were 86% (95% CI 81-90), 81% (95% CI 78-85), and 20.36 (95% CI 2.72-152.67), respectively, while these modalities of DNA-image cytometry were 89% (95% CI 83-94), 99% (95% CI 97-100), and 446.08 (95% CI 73.36-2712.43), respectively. Results of a pairwise comparison between each modality demonstrated that specificity, area under the curve (AUC), and Q(∗) index of DNA-image cytometry was significantly higher than that of the OralCDx brush biopsy (Z=2.821, p0.05). In conclusion, the meta-analysis of the published studies indicated that DNA-image cytometry is more accurate than the OralCDx brush biopsy in diagnosing oral precancer and oral cancer. Copyright © 2015 Elsevier Ltd. All rights reserved.

Increasing the magnetic helicity content of a plasma by pulsing a magnetized source.

Science.gov (United States)

Woodruff, S; Stallard, B W; McLean, H S; Hooper, E B; Bulmer, R; Cohen, B I; Hill, D N; Holcomb, C T; Moller, J; Wood, R D

2004-11-12

By operating a magnetized coaxial gun in a pulsed mode it is possible to produce large voltage pulses of duration approximately 500 mus while reaching a few kV, giving a discrete input of helicity into a spheromak. In the sustained spheromak physics experiment (SSPX), it is observed that pulsing serves to nearly double the stored magnetic energy and double the temperature. We discuss these results by comparison with 3D MHD simulations of the same phenomenon.

Experimental investigation of coaxial-gun-formed plasmas injected into a background transverse magnetic field or plasma

Science.gov (United States)

Zhang, Yue; Fisher, Dustin M.; Gilmore, Mark; Hsu, Scott C.; Lynn, Alan G.

2018-05-01

Injection of coaxial-gun-formed magnetized plasmas into a background transverse vacuum magnetic field or into a background magnetized plasma has been studied in the helicon-cathode (HelCat) linear plasma device at the University of New Mexico [M. Gilmore et al., J. Plasma Phys. 81, 345810104 (2015)]. A magnetized plasma jet launched into a background transverse magnetic field shows emergent kink stabilization of the jet due to the formation of a sheared flow in the jet above the kink stabilization threshold 0.1kVA [Y. Zhang et al., Phys. Plasmas 24, 110702 (2017)]. Injection of a spheromak-like plasma into a transverse background magnetic field led to the observation of finger-like structures on the side with a stronger magnetic field null between the spheromak and the background field. The finger-like structures are consistent with magneto-Rayleigh-Taylor instability. Jets or spheromaks launched into a background, low-β magnetized plasma show similar behavior as above, respectively, in both cases.

40 CFR 720.40 - General.

Science.gov (United States)

2010-07-01

... the e-PMN software as follows: (A) Website. Go to EPA's TSCA New Chemicals Program website at http... from the CDX website at http://cdx.epa.gov/epa_home.asp. (f) New information. During the notice review... submitted the test data to EPA. (ii) The date the test data were submitted to EPA. (iii) A citation for the...

Antral atrophy, intestinal metaplasia, and pre-neoplastic markers in Mexican children with Helicobacter pylori-positive and negative gastritis

Science.gov (United States)

Villarreal-Calderon, Rodolfo; Luévano-González, Arturo; Aragón-Flores, Mariana; Zhu, Hongtu; Yuan, Ying; Xiang, Qun; Yan, Benjamin; Stoll, Kathryn Anne; Cross, Janet V.; Iczkowski, Kenneth A.; Mackinnon, Alexander Craig

2015-01-01

Chronic inflammation and infection are major risk factors for gastric carcinogenesis in adults. As chronic gastritis is common in Mexican children, diagnosis of Helicobacter pylori and other causes of gastritis are critical for the identification of children who would benefit from closer surveillance. Antral biopsies from 82 Mexican children (mean age 8.3±4.8y) with chronic gastritis (36 H. pylori +, 46 H. pylori -) were examined for gastritis activity, atrophy, intestinal metaplasia, and immunohistochemical expression of gastric carcinogenesis biomarkers CDX2, ephrin type-B receptor 4, matrix metalloproteinase 3 (MMP3), macrophage migration inhibitory factor (MIF), p53, β-catenin, and E-cadherin. Atrophy was diagnosed in 7/82 (9%) and intestinal metaplasia in 5/82 (6%) by routine histology, while 6 (7%) additional children (3 H. pylori +) exhibited aberrant CDX2 expression without intestinal metaplasia. Significant positive correlations were seen between EphB4, MMP3, and MIF (p<0.0001). Atrophy and follicular pathology were more frequent in H. pylori + biopsies (p<0.0001), while intestinal metaplasia and CDX2 expression showed no significant correlation with H. pylori status. Antral biopsies demonstrating atrophy, intestinal metaplasia, and/or aberrant CDX2 expression were seen in 21.95 % (18/82) of the children, potentially identifying those who would benefit from closer surveillance and preventive dietary strategies. Biomarkers CDX2, EphB4, MMP3, and MIF may be useful in the work-up of pediatric gastritis. PMID:24656654

Photophysical and photoprototropic characteristics of phenothiazine in aqueous and β-cyclodextrin media

Energy Technology Data Exchange (ETDEWEB)

Rajamohan, Rajaram, E-mail: rajmohanau@gmail.com [Department of Chemistry, S.K.P Institute of Technology, Tiruvannamalai 606611 (India); Nayaki, Sundararajulu Kothai [Chemistry Section, FEAT, Annamalai University, Annamalainagar 608002 (India); Sivakumar, Krishnamoorthy [Department of Chemistry, SCSV University, Enathur, Kanchipuram 631561 (India); Swaminathan, Meenakshisundaram [Department of Chemistry, Annamalai University, Annamalainagar 608002 (India)

2015-12-15

The photophysical and photoprototropic characteristics of phenothiazine (PTZ) in aqueous and β-cyclodextrin (β-CD) media have been investigated using absorption, steady state and time resolved fluorescence measurements. The absorbance and fluorescence intensities of the neutral and monocationic forms of PTZ are enhanced by the addition of β-cyclodextrin and it is due to the formation of 1:1 inclusion complex. The formation of complex is confirmed by the decay analysis and Job's continuous variation method in the liquid state while FT-IR spectral study and SEM image analysis in the solid state. The peak and pK{sub a}* values of PTZ in aqueous media are higher than in β-CD medium, which reveals that the >NH group of PTZ lies in the β-CD cavity. - Highlights: • Increase in the absorbance and fluorescence intensity of PTZ by the addition of β-CDx is confirmed the complex formation. • Biexponential decay is noticed for PTZ by the addition of β-CDx is due to the formation of inclusion complex. • FT-IR and SEM images analysis confirms complex between PTZ and β-CDx in solid state. • The pK{sub a} and pK{sub a}* values of PTZ in aqueous medium is higher than in β-CDx medium, which reveals that the >NH group of PTZ lies in the β-CDx cavity. • The orientation of the inclusion complex is proposed by PatchDock server.

Magnetohydrodynamic Particle Acceleration Processes: SSX Experiments, Theory and Astrophysical Applications

International Nuclear Information System (INIS)

Matthaeus, W.; Brown, M.

2006-01-01

This is the final technical report for a funded program to provide theoretical support to the Swarthmore Spheromak Experiment. We examined mhd relaxation, reconnecton between two spheromaks, particle acceleration by these processes, and collisonless effects, e.g., Hall effect near the reconnection zone,. Throughout the project, applications to space plasma physics and astrophysics were included. Towards the end of the project we were examining a more fully turbulent relaxation associated with unconstrained dynamics in SSX. We employed experimental, spacecraft observations, analytical and numerical methods.

Final Technical Report for NSF/DOE partnership grant ER54905; 2006-2009

International Nuclear Information System (INIS)

Stenzel, Reiner; Urrutia, J. Manuel

2009-01-01

The nonlinear physics of electron magnetohydrodynamics (EMHD) in plasmas. Time-varying wave magnetic field exceeding the background magnetic field produces highly nonlinear whistler mode since the wave dispersion depends on the total magnetic field. There exists no theory for such whistler modes. The present experimental work is the first one to explore this regime of nonlinear whistlers. A field-reversed configuration has been found which has the same vortex topology as an MHD spheromak, termed a whistler spheromak. Whistler mirrors have compressed and twisted field lines propagating in the whistler mode. Their helicity properties have been studied. Whistler spheromaks and mirrors have different propagation and damping characteristics. Wave collisions have been studied. Head-on collisions of two whistler spheromaks form a stationary field-reversed configuration (FRC) without helicity. When whistler spheromaks are excited the toroidal current flows mainly in the toroidal null line. It is only carried by electrons since ion currents and displacement currents are negligible. A change in the poloidal (axial) magnetic field induces a toroidal electric field which drives the current. Magnetic energy is dissipated and converted into electron kinetic energy. This process is called magnetic reconnection in 2D geometries, which are simplifications for theoretical convenience but rarely occur in nature. A crucial aspect of reconnection is its rate, determined by the electron collisionality. Regular Coulomb collisions can rarely account for the observed reconnection rates. In the present experiments we have also observed fast reconnection and explained it by electron transit time damping in the finite-size null layer. Electrons move faster than a whistler spheromak, hence transit through the toroidal null line where they are freely accelerated. The transit time is essentially the collision time but no particle collisions are required. Strong electron heating and visible light

NIMROD simulations and physics assessment of possible designs for a next generation Steady Inductive Helicity Injection HIT device

Science.gov (United States)

Penna, James; Morgan, Kyle; Grubb, Isaac; Jarboe, Thomas

2017-10-01

The Helicity Injected Torus - Steady Inductive 3 (HIT-SI3) experiment forms and maintains spheromaks via Steady Inductive Helicity Injection (SIHI) using discrete injectors that inject magnetic helicity via a non-axisymmetric perturbation and drive toroidally symmetric current. Newer designs for larger SIHI-driven spheromaks incorporate a set of injectors connected to a single external manifold to allow more freedom for the toroidal structure of the applied perturbation. Simulations have been carried out using the NIMROD code to assess the effectiveness of various imposed mode structures and injector schema in driving current via Imposed Dynamo Current Drive (IDCD). The results are presented here for varying flux conserver shapes on a device approximately 1.5 times larger than the current HIT-SI3 experiment. The imposed mode structures and spectra of simulated spheromaks are analyzed in order to examine magnetic structure and stability and determine an optimal regime for IDCD sustainment in a large device. The development of scaling laws for manifold operation is also presented, and simulation results are analyzed and assessed as part of the development path for the large scale device.

Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression

DEFF Research Database (Denmark)

Pinto, Rita; Hansen, Lars; Hintze, John

2017-01-01

to be a limitation. Here, we report that the combined use of genome editing tools and last generation Tet-On systems can resolve these issues. Our principle is based on precise integration of inducible transcriptional elements (coined PrIITE) targeted to: (i) exons of an endogenous gene of interest (GOI) and (ii......Tetracycline-based inducible systems provide powerful methods for functional studies where gene expression can be controlled. However, the lack of tight control of the inducible system, leading to leakiness and adverse effects caused by undesirable tetracycline dosage requirements, has proven......) a safe harbor locus. Using PrIITE cells harboring a GFP reporter or CDX2 transcription factor, we demonstrate discrete inducibility of gene expression with complete abrogation of leakiness. CDX2 PrIITE cells generated by this approach uncovered novel CDX2 downstream effector genes. Our results provide...

Comparison of U-Pu-Mo, U-Pu-Nb, U-Pu-Ti and U-Pu-Zr alloys; Comparaison des alliages U-Pu-Mo, U-Pu-Nb, U-Pu-Ti, U-Pu-Zr

Energy Technology Data Exchange (ETDEWEB)

Boucher, R; Barthelemy, P [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1964-07-01

The data concerning the U-Pu, U-Pu-Mo and U-Pu-Nb are recalled. The results obtained with U-Pu-Ti and U-Pu-Zr alloys containing 15-20 per cent Pu and 10 wt. per cent ternary element are reported. The transformation temperatures, the expansion coefficients, the nature of phases, the thermal cycling behaviour have been determined. A list of the principal properties of these different alloys is presented and the possibilities of their use as fast reactor's fuel element are considered. The U-Pu-Ti alloys seem to be quite promising: easiness of fabrication, large thermal stability, excellent behaviour in air, small quantity of zeta phase, temperature of solidus superior to 1100 deg. C. (authors) [French] On rappelle brievement les connaissances acquises sur les alliages U-Pu, U-Pu-Mo et U-Pu-Nb. On presente les resultats obtenus avec les alliages U-Pu-Ti et U-Pu-Zr pour des teneurs de 15 a 20 pour cent de plutonium et 10 pour cent en poids d'element ternaire. On a determine les temperatures de transformation, les coefficients de dilatation, la nature des phases, la conductibilite thermique a 20 deg. C, la tenue au cyclage thermique et diverses autres proprietes. Un tableau resume les principales proprietes des divers alliages. On considere les possibilites d'emploi de ces alliages comme combustibles de reacteur rapide. Les alliages U-Pu-Ti paraissent particulierement interessants: facilite d'elaboration, stabilite thermique etendue, tenue dans l'air excellente, faible quantite de la phase U-Pu zeta, temperature de fusion commencante superieure a 1100 deg. C. (auteurs)

Contrasting Binding of Fisetin and daidzein in γ-Cyclodextrin Nanocavity

OpenAIRE

Pahari, Biswapathik; Sengupta, Bidisha; Chakraborty, Sandipan; Thomas, Briannica; McGowan, Dyffreyon; Sengupta, Pradeep K.

2012-01-01

Steady state and time resolved fluorescence along with anisotropy and induced circular dichroism (ICD) spectroscopy provide useful tools to observe and understand the behavior of the therapeutically important plant flavonoids fisetin and daidzein in γ-cyclodextrin (γ-CDx) nanocavity. Benesi-Hildebrand plots indicated 1:1 stoichiometry for both the supramolecular complexes. However the mode of the binding of fisetin significantly differs from daidzein in γ-CDx, as is observed from ICD spectra ...

Isotope shift of 234U, 236U, 238U in U I

International Nuclear Information System (INIS)

Gagne, J.M.; Nguyen Van, S.; Saint-Dizier, J.P.; Pianarosa, P.

1976-01-01

New and very accurate data of isotope shifts and relative isotope shifts in 234 U, 236 U, 238 U are presented. The invariance of the relative isotope shift, for the transitions we have investigated, supports the hypothesis that the so called specific mass effect is negligible in uranium

The role of improved fusion concepts

International Nuclear Information System (INIS)

Nelson, D.B.; Linford, R.K.; Liu, C.S.; Logan, B.G.; Rose, P.H.

1985-01-01

The U.S. Dept. of Energy discusses concept improvement in the tokamak and concept improvement in the mirror. Controlled Thermonuclear Research comments on what constitutes an attractive fusion reactor, and provides a table of achieved parameters of RFP, FRC and the spheromak experiments. GA Technologies Inc. remarks on the direction which industry must take in the fusion program. The Lawrence Livermore National Laboratory concentrates on commercial reactor studies. Spectra Technology focuses on problems dealing with fusion proponents making a convincing and clear economic argument for fusion based on a mils per kilowat basis, and the large costs of flagship experiments. The Oak Ridge National Laboratory remarks on the need for an economic energy source for fusion. A table of cost of electricity contours is shown

The role of improved fusion concepts

Energy Technology Data Exchange (ETDEWEB)

Nelson, D.B.; Linford, R.K.; Liu, C.S.; Logan, B.G.; Rose, P.H.

1985-06-01

The U.S. Dept. of Energy discusses concept improvement in the tokamak and concept improvement in the mirror. Controlled Thermonuclear Research comments on what constitutes an attractive fusion reactor, and provides a table of achieved parameters of RFP, FRC and the spheromak experiments. GA Technologies Inc. remarks on the direction which industry must take in the fusion program. The Lawrence Livermore National Laboratory concentrates on commercial reactor studies. Spectra Technology focuses on problems dealing with fusion proponents making a convincing and clear economic argument for fusion based on a mils per kilowat basis, and the large costs of flagship experiments. The Oak Ridge National Laboratory remarks on the need for an economic energy source for fusion. A table of cost of electricity contours is shown.

EMAPS: An Efficient Multiscale Approach to Plasma Systems with Non-MHD Scale Effects

Energy Technology Data Exchange (ETDEWEB)

Omelchenko, Yuri A. [SciberQuest, Inc., Del Mar, CA (United States); Karimabadi, Homa [SciberQuest, Inc., Del Mar, CA (United States)

2014-10-14

Using Discrete-Event Simulation (DES) as a novel paradigm for time integration of large-scale physics-driven systems, we have achieved significant breakthroughs in simulations of multi-dimensional magnetized plasmas where ion kinetic and finite Larmor radius (FLR) and Hall effects play a crucial role. For these purposes we apply a unique asynchronous simulation tool: a parallel, electromagnetic Particle-in-Cell (PIC) code, HYPERS (Hybrid Particle Event-Resolved Simulator), which treats plasma electrons as a charge neutralizing fluid and solves a self-consistent set of non-radiative Maxwell, electron fluid equations and ion particle equations on a structured computational grid. HYPERS enables adaptive local time steps for particles, fluid elements and electromagnetic fields. This ensures robustness (stability) and efficiency (speed) of highly dynamic and nonlinear simulations of compact plasma systems such spheromaks, FRCs, ion beams and edge plasmas. HYPERS is a unique asynchronous code that has been designed to serve as a test bed for developing multi-physics applications not only for laboratory plasma devices but generally across a number of plasma physics fields, including astrophysics, space physics and electronic devices. We have made significant improvements to the HYPERS core: (1) implemented a new asynchronous magnetic field integration scheme that preserves local divB=0 to within round-off errors; (2) Improved staggered-grid discretizations of electric and magnetic fields. These modifications have significantly enhanced the accuracy and robustness of 3D simulations. We have conducted first-ever end-to-end 3D simulations of merging spheromak plasmas. The preliminary results show: (1) tilt-driven relaxation of a freely expanding spheromak to an m=1 Taylor helix configuration and (2) possibility of formation of a tilt-stable field-reversed configuration via merging and magnetic reconnection of two double-sided spheromaks with opposite helicities.

A Challenging Solar Eruptive Event of 18 November 2003 and the Causes of the 20 November Geomagnetic Superstorm. IV. Unusual Magnetic Cloud and Overall Scenario

Science.gov (United States)

Grechnev, V. V.; Uralov, A. M.; Chertok, I. M.; Belov, A. V.; Filippov, B. P.; Slemzin, V. A.; Jackson, B. V.

2014-12-01

The geomagnetic superstorm of 20 November 2003 with Dst=-422 nT, one of the most intense in history, is not well understood. The superstorm was caused by a moderate solar eruptive event on 18 November, comprehensively studied in our preceding Papers I - III. The analysis has shown a number of unusual and extremely complex features, which presumably led to the formation of an isolated right-handed magnetic-field configuration. Here we analyze the interplanetary disturbance responsible for the 20 November superstorm, compare some of its properties with the extreme 28 - 29 October event, and reveal a compact size of the magnetic cloud (MC) and its disconnection from the Sun. Most likely, the MC had a spheromak configuration and expanded in a narrow angle of ≤ 14∘. A very strong magnetic field in the MC up to 56 nT was due to the unusually weak expansion of the disconnected spheromak in an enhanced-density environment constituted by the tails of the preceding ICMEs. Additional circumstances favoring the superstorm were i) the exact impact of the spheromak on the Earth's magnetosphere and ii) the almost exact southward orientation of the magnetic field, corresponding to the original orientation in its probable source region near the solar disk center.

Comparison of U-Pu-Mo, U-Pu-Nb, U-Pu-Ti and U-Pu-Zr alloys

International Nuclear Information System (INIS)

Boucher, R.; Barthelemy, P.

1964-01-01

The data concerning the U-Pu, U-Pu-Mo and U-Pu-Nb are recalled. The results obtained with U-Pu-Ti and U-Pu-Zr alloys containing 15-20 per cent Pu and 10 wt. per cent ternary element are reported. The transformation temperatures, the expansion coefficients, the nature of phases, the thermal cycling behaviour have been determined. A list of the principal properties of these different alloys is presented and the possibilities of their use as fast reactor's fuel element are considered. The U-Pu-Ti alloys seem to be quite promising: easiness of fabrication, large thermal stability, excellent behaviour in air, small quantity of zeta phase, temperature of solidus superior to 1100 deg. C. (authors) [fr

Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice.

Science.gov (United States)

Sasada, Tatsunari; Hinoi, Takao; Saito, Yasufumi; Adachi, Tomohiro; Takakura, Yuji; Kawaguchi, Yasuo; Sotomaru, Yusuke; Sentani, Kazuhiro; Oue, Naohide; Yasui, Wataru; Ohdan, Hideki

2015-01-01

The gastrointestinal tract is continuously exposed to a variety of chemicals and commensal bacteria. Recent studies have shown that changes in gut microbial populations caused by chlorine or other chemicals in the drinking water influence the development of human colorectal cancer, although the mechanism of tumorigenesis in the gut epithelium is obfuscated by the diversity of microflora and complexity of the tumor microenvironment. In this regard, mouse models that recapitulate human colorectal cancer are an invaluable tool. In this study, we used two conditional adenomatous polyposis coli (Apc) knockout mouse models to investigate the effect of chlorinated water on tumorigenesis in the digestive tract. Mice with colon-specific carcinoma--caused by either chromosomal (CDX2P 9.5-NLS Cre;Apc(+/flox), abbreviated to CPC;Apc) or microsatellite (CDX2P9.5-G19Cre;Apc(flox/flox) and CDX2P9.5-G22Cre;Apc(flox/flox)) instability, respectively--were administered chlorinated (10.0 mg/L chlorine) or tap (0.7 mg/L chlorine) water and evaluated for colon polyp formation. In CPC;Apc mice given chlorinated drinking water, tumors tended to develop in the colon, whereas in those that drank tap water, tumors were mostly observed in the small intestine. There was no difference in the rate of tumor formation of CDX2P9.5-G19Cre;Apc(flox/flox) and CDX2P9.5-G22Cre;Apc(flox/flox) mice consuming chlorinated as compared to tap water, suggesting that microsatellite instability in the Apc gene does not significantly affect tumorigenesis. Chlorinated water altered the enteric environment by reducing the fecal populations of the obligatory anaerobes Clostridium perfringens and C. difficile, as well as species belonging to the Atopobium cluster, including Enterobacteriaceae and Staphylococcus sp., which was associated with colon tumorigenesis in CPC;Apc mice. These results suggest that differences in tumorigenesis among CPC;Apc mice consuming chlorinated versus tap water may be due to differences

Equilibrium electrode U(4)-U and redox U(4)-U(3) potentials in molten alkali metal chlorides medium

Energy Technology Data Exchange (ETDEWEB)

Smirnov, M V; Kudyakov, V Ya; Komarov, V E; Salyulev, A B [AN SSSR, Sverdlovsk. Inst. Ehlektrokhimii

1979-02-01

Conditional standard electrode potentials of uranium are determined for diluted solutions of its tetrachloride in alkali metal chloride melts (LiCl, NaCl, NaCl-KCl, KCl, RbCl and CsCl) when using U(4) ion activity coefficient values experimentally found by the tensimetric method. These potentials shift to the electronegative side at the temperature decrease and alkali cation radius increase rsub(Msup(+)) according to the empiric ratio E*U(4)-U= -3.06+6.87x10/sup -4/ T-(1.67-10/sup -4/T-0.44) 1/rsub(Msup(+)) +-0.01. The temperature dependences of formal conditional redox potentials of the U(4)-U(3) system for above melted chlorides are estimated. The E*U(4)-U(3) value also becomes more electronegative in the series LiCl, NaCl, NaCl-KCl, KCl, RbCl and CsCl. This alternation is satisfactorily described by the empiric expression E*U(4)-U(3)= -1.74+1.74x10/sup -4/T-(0.71x10/sup -4/T-0.20) 1rsub(Msup(+)) +-0.05. The calculated values Eu*(4)-U(3) are compared with those directly measured for the NaCl-KCl equimolar mixture and 3LiCl-2KCl eutectic mixture. A satisfactory confirmity has been observed.

Equilibrium electrode U(4)-U and redox U(4)-U(3) potentials in molten alkali metal chlorides medium

International Nuclear Information System (INIS)

Smirnov, M.V.; Kudyakov, V.Ya.; Komarov, V.E.; Salyulev, A.B.

1979-01-01

Conditional standard electrode potentials of uranium are determined for diluted solutions of its tetrachloride in alkali metal chloride melts (LiCl, NaCl, NaCl-KCl, KCl, RbCl and CsCl) when using U(4) ion activity coefficient values experimentally found by the tensimetric method. These potentials shift to the electronegative side at the temperature decrease and alkali cation radius increase rsub(Msup(+)) according to the empiric ratio E*U(4)-U= -3.06+6.87x10 -4 T-(1.67-10 -4 T-0.44) 1/rsub(Msup(+)) +-0.01. The temperature dependences of formal conditional redox potentials of the U(4)-U(3) system for above melted chlorides are estimated. The E*U(4)-U(3) value also becomes more electronegative in the series LiCl, NaCl, NaCl-KCl, KCl, RbCl and CsCl. This alternation is satisfactorily described by the empiric expression E*U(4)-U(3)= -1.74+1.74x10 -4 T-(0.71x10 -4 T-0.20) 1rsub(Msup(+)) +-0.05. The calculated values Eu*(4)-U(3) are compared with those directly measured for the NaCl-KCl equimolar mixture and 3LiCl-2KCl eutectic mixture. A satisfactory confirmity has been observed

Optimization of the Magnetic Field Structure for Sustained Plasma Gun Helicity Injection for Magnetic Turbulence Studies at the Bryn Mawr Plasma Laboratory

Science.gov (United States)

Cartagena-Sanchez, C. A.; Schaffner, D. A.; Johnson, H. K.; Fahim, L. E.

2017-10-01

A long-pulsed magnetic coaxial plasma gun is being implemented and characterized at the Bryn Mawr Plasma Laboratory (BMPL). A cold cathode discharged between the cylindrical electrodes generates and launches plasma into a 24cm diameter, 2m long chamber. Three separately pulsed magnetic coils are carefully positioned to generate radial magnetic field between the electrodes at the gun edge in order to provide stuffing field. Magnetic helicity is continuously injected into the flux-conserving vacuum chamber in a process akin to sustained slow-formation of spheromaks. The aim of this source, however, is to supply long pulses of turbulent magnetized plasma for measurement rather than for sustained spheromak production. The work shown here details the optimization of the magnetic field structure for this sustained helicity injection.

U.S. Korean Youth's Ideas and Experience of U.S. Education, U.S. Society, and U.S. History

Science.gov (United States)

An, Sohyun

2009-01-01

Drawing on and conversing with the large body of research and literature on young people's historical understanding, Asian American education, transnational migration, and Korean American studies, this dissertation research explored contemporary U.S. Korean youth's ideas and experiences of U.S. education, U.S. society and U.S. history.…

Corruption of homeostatic mechanisms in the guanylyl cyclase C signaling pathway underlying colorectal tumorigenesis.

Science.gov (United States)

Li, Peng; Waldman, Scott A

2010-08-01

Colon cancer, the second leading cause of cancer-related mortality worldwide, originates from the malignant transformation of intestinal epithelial cells. The intestinal epithelium undergoes a highly organized process of rapid regeneration along the crypt-villus axis, characterized by proliferation, migration, differentiation and apoptosis, whose coordination is essential to maintaining the mucosal barrier. Disruption of these homeostatic processes predisposes cells to mutations in tumor suppressors or oncogenes, whose dysfunction provides transformed cells an evolutionary growth advantage. While sequences of genetic mutations at different stages along the neoplastic continuum have been established, little is known of the events initiating tumorigenesis prior to adenomatous polyposis coli (APC) mutations. Here, we examine a role for the corruption of homeostasis induced by silencing novel tumor suppressors, including the intestine-specific transcription factor CDX2 and its gene target guanylyl cyclase C (GCC), as early events predisposing cells to mutations in APC and other sequential genes that initiate colorectal cancer. CDX2 and GCC maintain homeostatic regeneration in the intestine by restricting cell proliferation, promoting cell maturation and adhesion, regulating cell migration and defending the intestinal barrier and genomic integrity. Elimination of CDX2 or GCC promotes intestinal tumor initiation and growth in aged mice, mice carrying APC mutations or mice exposed to carcinogens. The roles of CDX2 and GCC in suppressing intestinal tumorigenesis, universal disruption in their signaling through silencing of hormones driving GCC, and the uniform overexpression of GCC by tumors underscore the potential value of oral replacement with GCC ligands as targeted prevention and therapy for colorectal cancer.

Determination of the isotopic ratio 234 U/238 U and 235 U/238 U in uranium commercial reagents by alpha spectroscopy

International Nuclear Information System (INIS)

Iturbe G, J.L.

1990-02-01

In this work the determination of the isotope ratio 234 U/ 238 U and 235 U/ 238 U obtained by means of the alpha spectroscopy technique in uranium reagents of commercial marks is presented. The analyzed uranium reagents were: UO 2 (*) nuclear purity, UO 3 (*) poly-science, metallic uranium, uranyl nitrate and uranyl acetate Merck, uranyl acetate and uranyl nitrate Baker, uranyl nitrate (*) of the Refinement and Conversion Department of the ININ, uranyl acetate (*) Medi-Lab Sigma of Mexico and uranyl nitrate Em Science. The obtained results show that the reagents that are suitable with asterisk (*) are in radioactive balance among the one 234 U/ 238 U, since the obtained value went near to the unit. In the case of the isotope ratio 235 U/ 238 U the near value was also obtained the one that marks the literature that is to say 0.04347, what indicates that these reagents contain the isotope of 235 U in the percentage found in the nature of 0.71%. The other reagents are in radioactive imbalance among the 234 U/ 238 U, the found values fluctuated between 0.4187 and 0.1677, and for the quotient of activities 235 U/ 238 U its were of 0.0226, and the lowest of 0.01084. Also in these reagents it was at the 236 U as impurity. The isotope of 236 U is an isotope produced artificially, for what is supposed that the reagents that are in radioactive imbalance were synthesized starting from irradiated fuel. (Author)

Operation of SPHEX in helium and deuterium

International Nuclear Information System (INIS)

Gee, S.J.; Rusbridge, M.G.

1994-01-01

In the SPHEX spheromak a magnetised Marshall gun generates a toroidal plasma with embedded toroidal and poloidal magnetic fields. The resulting spheromak plasma is almost entirely governed by the programmed gun flux, Ψ G . Surprisingly then following ejection, the voltage V G between the gun electrodes attains a value which is largely independent of Ψ G . The SPHEX power supply acts as an approximate current source, consequently V G is entirely determined by the non linear load presented to it by the plasma, for any given gun current. The signature of initial gas breakdown in the gun is a period of low V G (∼ 140 V) called the pedestal. This is interpreted as the electrode sheath voltage, and persists throughout the discharge. After the initial gas breakdown, the gun voltage remains at this pedestal voltage as the gun current builds up, until the instant of plasma ejection when it starts to rise rapidly. Ejection is governed by a simple force balance at the gun muzzle, occurring when the internal azimuthal field due to the gun current exceeds the external radial field from the gun solenoid. The sharp rise in V G continues until it reaches some critical value when it abruptly stops, suggesting that a breakdown of the 'magnetic insulation' occurs, which is then subsequently maintained at a finite V G throughout the discharge. This implied breakdown cannot be 'gas like' which would tend to reduce V G to the pedestal voltage and would divert all of the gun current from the spheromak, neither of which are seen. Nor can it be due to 'short flux' linking the gun electrodes (effectively bypassing the spheromak) since this would short out the electrodes at any voltage. We propose that the observed gun voltage is limited by breakdown of the azimuthal magnetic insulation between the gun electrodes, by ions which acquire enough energy so that their Larmor diameter equals the inter electrode gap. (author) 7 refs., 4 figs

Operation of SPHEX in helium and deuterium

Energy Technology Data Exchange (ETDEWEB)

Gee, S.J.; Rusbridge, M.G. [Manchester Univ. (United Kingdom). Dept. of Physics

1994-12-31

In the SPHEX spheromak a magnetised Marshall gun generates a toroidal plasma with embedded toroidal and poloidal magnetic fields. The resulting spheromak plasma is almost entirely governed by the programmed gun flux, {Psi}{sub G}. Surprisingly then following ejection, the voltage V{sub G} between the gun electrodes attains a value which is largely independent of {Psi}{sub G}. The SPHEX power supply acts as an approximate current source, consequently V{sub G} is entirely determined by the non linear load presented to it by the plasma, for any given gun current. The signature of initial gas breakdown in the gun is a period of low V{sub G} ({approx} 140 V) called the pedestal. This is interpreted as the electrode sheath voltage, and persists throughout the discharge. After the initial gas breakdown, the gun voltage remains at this pedestal voltage as the gun current builds up, until the instant of plasma ejection when it starts to rise rapidly. Ejection is governed by a simple force balance at the gun muzzle, occurring when the internal azimuthal field due to the gun current exceeds the external radial field from the gun solenoid. The sharp rise in V{sub G} continues until it reaches some critical value when it abruptly stops, suggesting that a breakdown of the `magnetic insulation` occurs, which is then subsequently maintained at a finite V{sub G} throughout the discharge. This implied breakdown cannot be `gas like` which would tend to reduce V{sub G} to the pedestal voltage and would divert all of the gun current from the spheromak, neither of which are seen. Nor can it be due to `short flux` linking the gun electrodes (effectively bypassing the spheromak) since this would short out the electrodes at any voltage. We propose that the observed gun voltage is limited by breakdown of the azimuthal magnetic insulation between the gun electrodes, by ions which acquire enough energy so that their Larmor diameter equals the inter electrode gap. (author) 7 refs., 4 figs.

Conceptual design of a cassette compact toroid reactor (the zero-phase study) - Quick replacement of the reactor core

International Nuclear Information System (INIS)

Nishikawa, M.; Narikawa, T.; Iwamoto, M.; Watanabe, K.

1986-01-01

A study of a conceptual design for a ''cassette'' compact toroid reactor has been performed that emphasizes quick replacement handling. The core plasma, spheromak, is ohmically heated in a merging process between the core plasma and the gun-produced spheromak. The quick handling of replacement accomplished by using a functional material, a shape memory alloy (SMA) joint, which is proposed for release from first-wall high neutron loading in a newly devised mechanical and structural method. The SMA joint can be used for connecting or disconnecting the coupling by simply controlling the SMA temperature without the need for a robot system. Effective heat removal from the first wall and thermal and electromagnetic stress in a fusion core with very high heat flux are discussed from an engineering standpoint

Anti-U-like as an alloantibody in S-s-U- and S-s-U+(var) black people.

Science.gov (United States)

Peyrard, Thierry; Lam, Yin; Saison, Carole; Arnaud, Lionel; Babinet, Jérôme; Rouger, Philippe; Bierling, Philippe; Janvier, Daniel

2012-03-01

S, s, and U antigens belong to the MNS system. They are carried by glycophorin B (GPB), encoded by GYPB. Black people with the low-prevalence S-s- phenotype, either U- or U+(var), can make a clinically significant anti-U. Anti-U-like, a cold immunoglobulin G autoantibody quite commonly observed in S-s+U+ black persons, was previously described to be nonreactive with ficin-, α-chymotrypsin-, and pronase-treated red blood cells (RBCs); nonreactive or weakly reactive with papain-treated RBCs; and reactive with trypsin-treated RBCs. Here we describe, in S-s- people from different molecular backgrounds, an alloantibody to a high-prevalence GPB antigen, which presents the same pattern of reactivity with proteases as autoanti-U-like. Four S-s- patients with an alloantibody to a high-prevalence GPB antigen were investigated by serologic and molecular methods. An alloantibody was observed in two S-s-U-/Del GYPB, one S-s-U+(var)/GYPB(P2), and one S-s-U+(var)/GYPB(NY) patients. As this alloantibody showed the same pattern of reactivity with proteases as autoanti-U-like, we decided to name it "anti-U-like." Anti-U-like made by the two S-s-U- patients was reactive with the S-s-U+(var) RBCs of the two other patients. S-s-U-/Del GYPB, S-s-U+(var)/GYPB(P2), and S-s-U+(var)/GYPB(NY) patients can make an alloanti-U-like. Anti-U-like made by S-s-U- people appears reactive with GYPB(P2) and GYPB(NY) RBCs, which both express a weak and partial U-like reactivity. We recommend transfusing S-s-U- RBCs in S-s-U- patients showing alloanti-U-like. Our study contributes to a better understanding of alloimmunization to GPB in black people and confirms importance of genotyping in S-s- patients, especially those with sickle cell disease to be frequently transfused. © 2011 American Association of Blood Banks.

Behavior of uranium along Jucar River (Eastern Spain). Determination of 234U/238U and 235U/238U ratios

International Nuclear Information System (INIS)

Rodriguez-Alvarez, M.J.; Sanchez, F.

1995-01-01

The uranium concentration and the 234 U/ 238 U, 235 U/ 238 U activity ratios were studied in water samples from Jucar River, using low-level α-spectrometry. The effects of pH, temperature and salinity were considered and more detailed sampling was done in the neighbourhood of Cofrentes Nuclear Plant (Valencia, Spain). Changes were observed in the uranium concentration with the salinity and the 234 U/ 238 U activity ratio was found to vary with pH. Leaching and dilution, which depend on pH and salinity, are the probable mechanisms for these changes in the concentration of uranium and the activity ratios. (author) 25 refs.; 4 figs.; 1 tab

238U, 234U and 232Th in seawater

International Nuclear Information System (INIS)

Chen, J.H.; Edwards, R.L.; Wasserburg, G.J.

1986-01-01

We have developed techniques to determine 238 U, 234 U and 232 Th concentrations in seawater by isotope dilution mass spectrometry. Using these techniques, we have measured 238 U, 234 U and 232 Th in vertical profiles of unfiltered, acidified seawater from the Atlantic and 238 U and 234 U in vertical profiles from the Pacific. Determinations of 234 U/ 238 U at depths ranging from 0 to 4900 m in the Atlantic (7 0 44'N, 40 0 43'W) and the Pacific (14 0 41'N, 160 0 01'W) Oceans are the same within experimental error (±5per mille, 2σ). The average of these 234 U/ 238 U measurements is 144±2per mille (2σ) higher than the equilibrium ratio of 5.472 x 10 -5 . U concentrations, normalized to 35per mille salinity, range from 3.162 to 3.281 ng/g, a range of 3.8%. The average concentration of the Pacific samples (31 0 4'N, 159 0 1'W) is ∝1% higher than that of the Atlantic (7 0 44'N, 40 0 43'W and 31 0 49'N, 64 0 6'W). 232 Th concentrations from an Atlantic profile range from 0.092 to 0.145 pg/g. The observed constancy of the 234 U/ 238 U ratio is consistent with the predicted range of 234 U/ 238 U using a simple two-box model and the residence time of deep water in the ocean determined from 14 C. The variation in salinity-normalized U concentrations suggests that U may be much more reactive in the marine environment than previously thought. (orig./WB)

Transformation temperatures γU → δUZr2 Y γU →αU in U-Zr-Nb alloys

International Nuclear Information System (INIS)

Komar Varela, Carolina L.; Arico, Sergio F.; Gribaudo, Luis M.; Comision Nacional de Energia Atomica, General San Martin

2009-01-01

The international RERTR program has as primary objective the development of new fuels for research and test reactors to satisfy the requirement of low enrichment in 235 U (lower than 20 %). It is known that the cubic-phase (γU) has an excellent behaviour under irradiation. In this context, in the Materials Department (GIDAT-GAEN-CNEA) U-Zr-Nb alloys are considered candidates for the development of a high-density monolithic-type nuclear fuel. It is necessary to evaluate the thermodynamic parameters that allow to obtain a range of concentrations of the U-Zr-Nb system in which this phase can be retained in the metastable condition with the required 235 U density. In this work, eight U alloys with concentrations ranging from 13.9 to 43.7 wt.% Zr and from 0 to 6.4 wt.% Nb, were fabricated. Dynamical measurements of electrical resistivity, with a cooling rate of 4 o C/min, were performed and the results were analyzed. Considering this cooling rate, a Nb concentration of at least 17.8 wt. % would inhibit the transformation γU→ δUZr 2 and a concentration of al least 23.3 wt % would inhibit the γU → αU transformation. (author)

Juvenile idiopathic arthritis patients and their skeletal status: possible role of vitamin D receptor gene polymorphism.

Science.gov (United States)

Kostik, M M; Smirnov, A M; Demin, G S; Scheplyagina, L A; Larionova, V I

2014-01-01

We evaluated bone mineralization and metabolism changes related to vitamin D receptor (VDR) polymorphic genotypes in children with juvenile idiopathic arthritis. One hundred and ninety eight children (82 boys and 116 girls) were included in our study. Bone mineral density (BMD) was measured by lumbar spine DXA. Osteocalcin, CTX, parathyroid hormone, total and ionized calcium, inorganic phosphate, total alkaline phosphatase activity was utilized for assessment of bone metabolism. Molecular testing: TaqI (rs731236) and Cdx2 (rs11568820) polymorphisms of VDR were detected by RFLP. No differences in TaqI and Cdx2 haplotypes, genotypes and alleles distribution related with normal and low BMD (Zscore 90th percentile) had the highest frequency of allele A-contained genotypes (GA+AA) of Cdx2 VDR (p = 0.009). Girls with TT TaqI VDR, who never been treated by glucocorticoides had lower BMD-Zscore than C allele carriers (TT = -0.94SD [IQR: -2.1;-0.5], TC+CC = -0.62SD [IQR: -1.26;0.39], p = 0.03). Girls with Tanner I with TT had higher total and ionized Ca level than carriers of C allele (Ca: TT = 2.43 ± 0.15 mmol/l, TC+CC = 2.28 ± 0.2 mmol/l, p = 0.024; Ca(2+): TT = 1.15 ± 0.08 mmol/l, TC+CC = 1.06 ± 0.13 mmol/l, p = 0.026). Presence of TT genotype negatively correlated with BMD-Zscore (r = -0.28, p = 0.04), and positively with frequency of LBMD (r = 0.3, p = 0.037). Boy with GG Cdx2 genotype had lower total Ca (GG = 2.3 ± 0.17 mmol/l, GA+AA = 2.43 ± 0.17 mmol/l, p = 0.004) compare with carriers of A allele. Pubertal boys (Tanner IV-V) with GG had higher CTX (GG = 1.75 ± 0.11 ng/ml, GA+AA = 1.06 ± 0.07 ng/ml, p = 0.04. TT genotype of TaqI and GG genotype of Cdx2 VDR is a negative factor impact bone mineralization metabolism and linear growth.

Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients.

Science.gov (United States)

Morse, Michael A; Chapman, Robert; Powderly, John; Blackwell, Kimberly; Keler, Tibor; Green, Jennifer; Riggs, Renee; He, Li-Zhen; Ramakrishna, Venky; Vitale, Laura; Zhao, Biwei; Butler, Stephen A; Hobeika, Amy; Osada, Takuya; Davis, Thomas; Clay, Timothy; Lyerly, H Kim

2011-07-15

The use of tumor-derived proteins as cancer vaccines is complicated by tolerance to these self-antigens. Tolerance may be broken by immunization with activated, autologous, ex vivo generated and antigen-loaded, antigen-presenting cells (APC); however, targeting tumor antigen directly to APC in vivo would be a less complicated strategy. We wished to test whether targeted delivery of an otherwise poorly immunogenic, soluble antigen to APC through their mannose receptors (MR) would induce clinically relevant immunity. Two phase I studies were conducted with CDX-1307, a vaccine composed of human chorionic gonadotropin beta-chain (hCG-β) fused to an MR-specific monoclonal antibody, administered either locally (intradermally) or systemically (intravenously) in patients with advanced epithelial malignancies. An initial dose escalation of single-agent CDX-1307 was followed by additional cohorts of CDX-1307 combined with granulocyte-macrophage colony-stimulating factor (GM-CSF) and the Toll-like receptor (TLR) 3 agonist polyinosinic-polycytidylic acid (poly-ICLC) and TLR7/8 agonist resiquimod to activate the APC. CDX-1307 induced consistent humoral and T-cell responses to hCG-β when coadministered with TLR agonists. Greater immune responses and clinical benefit, including the longest duration of stable disease, were observed with immunization combined with local TLR agonists. Immune responses were induced equally efficiently in patients with elevated and nonelevated levels of serum hCG-β. Antibodies within the serum of vaccinated participants had tumor suppressive function in vitro. Toxicity consisted chiefly of mild injection site reactions. APC targeting and activation induce adaptive immunity against poorly immunogenic self-antigens which has implications for enhancing the efficacy of cancer immunotherapy.

Determination of the isotopic ratio {sup 234} U/{sup 238} U and {sup 235} U/{sup 238} U in uranium commercial reagents by alpha spectroscopy; Determinacion de la relacion isotopica {sup 234} U/{sup 238} U y {sup 235} U/{sup 238} U en reactivos comerciales de uranio por espectrometria alfa

Energy Technology Data Exchange (ETDEWEB)

Iturbe G, J L

1990-02-15

In this work the determination of the isotope ratio {sup 234} U/{sup 238} U and {sup 235} U/{sup 238} U obtained by means of the alpha spectroscopy technique in uranium reagents of commercial marks is presented. The analyzed uranium reagents were: UO{sub 2} (*) nuclear purity, UO{sub 3} (*) poly-science, metallic uranium, uranyl nitrate and uranyl acetate Merck, uranyl acetate and uranyl nitrate Baker, uranyl nitrate (*) of the Refinement and Conversion Department of the ININ, uranyl acetate (*) Medi-Lab Sigma of Mexico and uranyl nitrate Em Science. The obtained results show that the reagents that are suitable with asterisk (*) are in radioactive balance among the one {sup 234} U/{sup 238} U, since the obtained value went near to the unit. In the case of the isotope ratio {sup 235} U/{sup 238} U the near value was also obtained the one that marks the literature that is to say 0.04347, what indicates that these reagents contain the isotope of {sup 235} U in the percentage found in the nature of 0.71%. The other reagents are in radioactive imbalance among the {sup 234} U/{sup 238} U, the found values fluctuated between 0.4187 and 0.1677, and for the quotient of activities {sup 235} U/{sup 238} U its were of 0.0226, and the lowest of 0.01084. Also in these reagents it was at the {sup 236} U as impurity. The isotope of {sup 236} U is an isotope produced artificially, for what is supposed that the reagents that are in radioactive imbalance were synthesized starting from irradiated fuel. (Author)

Hydrogen absorption properties of U6Mn and U6Ni

International Nuclear Information System (INIS)

Ito, H.; Yamawaki, M.; Yamamoto, T.

1998-01-01

The hydrogen absorption properties of U, U 6 Mn and U 6 Ni were investigated at hydrogen pressures below 10 5 Pa. The pressure-composition (P-C) isotherms of U, U 6 Mn and U 6 Ni were obtained and the amounts of absorbed hydrogen for U, U 6 Mn and U 6 Ni were determined to be 3, 16.6 and 16.0 for x in MH x , where M is U, U 6 Mn and U 6 Ni, respectively. The desorption plateau pressures at 573 K decreased in the order: U 6 Mn-H>U 6 Ni-H>U-H. In addition, the results for the amounts of absorbed hydrogen suggests the formation of ternary hydrides U 6 MnH 18 and U 6 NiH 14 . (orig.)

Heterogeneity in the 238U/235U Ratios of Angrites.

Science.gov (United States)

Tissot, F.; Dauphas, N.; Grove, T. L.

2016-12-01

Angrites are differentiated meteorites of basaltic composition, of either volcanic or plutonic origin, that display minimal post-crystallization alteration, metamorphism, shock or impact brecciation. Because quenched angrites cooled very rapidly, all radiochronometric systems closed simultaneously in these samples. Quenched angrites are thus often used as anchors for cross-calibrating short-lived dating methods (e.g., 26Al-26Mg) and the absolute dating techniques (e.g, Pb-Pb). Due to the constancy of the 238U/235U ratio in natural samples, Pb-Pb ages have long been calculated using a "consensus" 238U/235U ratio, but the discovery of resolvable variations in the 238U/235U ratio of natural samples, means that the U isotopic composition of the material to date also has to be determined in order to obtain high-precision Pb-Pb ages. We set out (a) to measure at high-precision the 238U/235U ratio of a large array of angrites to correct their Pb-Pb ages, and (b) to identify whether all angrites have a similar U isotopic composition, and, if not, what were the processes responsible for this variability. Recently, Brennecka & Wadhwa (2012) suggested that the angrite-parent body had a homogeneous 238U/235U ratio. They reached this conclusion partly because they propagated the uncertainties of the U isotopic composition of the various U double spikes that they used onto the final 238U/235U ratio the sample. Because this error is systematic (i.e., it affects all samples similarly), differences in the δ238U values of samples corrected by the same double spike are better known than one would be led to believe if uncertainties on the spike composition are propagated. At the conference, we will present the results of the high-precision U isotope analyses for six angrite samples: NWA 4590, NWA 4801, NWA 6291, Angra dos Reis, D'Orbigny, and Sahara 99555. We will show that there is some heterogeneity in the δ238U values of the angrites and will discuss the possible processes by

Los Alamos Compact Toroid, fast liner, and High-Density Z-Pinch programs

International Nuclear Information System (INIS)

Linford, R.K.; Hammel, J.E.; Sherwood, H.R.

1982-01-01

The compact Toroid and High Density Z-Pinch are two of the plasma configurations presently being studied at Los Alamos. This paper summarizes these two programs along with the recently terminated Fast Liner Program. Included in this discussion is an analysis of compact Toroid formation techniques showing the tearing and reconnection of the fields that separate the spheromak from the radial fields of the coaxial source, and the final equilibrium state of the elongated FRC in the theta-pinch coil. In addition the typical dimensions of the geometry of the Fast Liner experiments are delineated Z-pinch and electrode assembly is displayed as is a graphic of the temporal behavior of the current required for radial equilibrium. Spheromak is examined in terms of formation, gross stability, and equilibrium and field reversed configuration is discussed in terms of gross stability, equilibrium, and confinement scaling

Compact toroidal plasmas: Simulations and theory

International Nuclear Information System (INIS)

Harned, D.S.; Hewett, D.W.; Lilliequist, C.G.

1983-01-01

Realistic FRC equilibria are calculated and their stability to the n=1 tilting mode is studied. Excluding kinetic effects, configurations ranging from elliptical to racetrack are unstable. Particle simulations of FRCs show that particle loss on open field lines can cause sufficient plasma rotation to drive the n=2 rotational instability. The allowed frequencies of the shear Alfven wave are calculated for use in heating of spheromaks. An expanded spheromak is introduced and its stability properties are studied. Transport calculations of CTs are described. A power balance model shows that many features of gun-generated CT plasmas can be explained by the dominance of impurity radiation. It is shown how the Taylor relaxation theory, applied to gun-generated CT plasmas, leads to the possibility of steady-state current drive. Lastly, applications of accelerated CTs are considered. (author)

Preparation of 235mU targets for 235U(n,n')235mU cross section measurements

International Nuclear Information System (INIS)

Bond, E.M.; Vieira, D.J.; Rundberg, R.S.; Glover, S.; Hynek, D.; Jansen, Y.; Becker, J.; Macri, R.

2008-01-01

This paper describes the preparation of samples for an experiment to measure the cross-section for 235 U(n,n') 235m U in a fast fission spectrum of neutrons provided by a fast pulsed reactor/critical assembly. Samples of 235m U have been prepared for the calibration of the internal conversion electron detector that is used for the 235m U measurement. Two methods are described for the preparation of 235 mU. The first method used a U-Pu chemical separation based on anion-exchange chromatography and the second method used an alpha recoil collection method. Thin, uniform samples of 235m U+ 235 U were prepared for the experiment using electrodeposition. (author)

Intenzitet stresa kod učitelja u osnovnim školama

OpenAIRE

Tomašević, Suzana; Horvat, Gordana; Leutar, Zdravka; Horvat, Gordana

2016-01-01

Cilj ovog rada bio je istražiti intenzitet stresa kod učitelja razredne i predmetne nastave u seoskim i gradskim osnovnim školama. Ovim istraživanjem želi se utvrditi postoji li statistički značajna razlika u intenzitetu stresa između učitelja razredne nastave i učitelja predmetne nastave s obzirom na mjesto rada, selo ili grad. U istraživanju je korišten psihologijski instrument za mjerenje percepcije stresa (PerceivedStressScale) (Cohen, S., Kamarck, T, Mermelstein, R. 1983). Istraživanj...

Environmental control of U concentration and 234U/238U in speleothems at subannual resolution

Science.gov (United States)

Hu, C.; Henderson, G. M.

2003-12-01

Trace element and isotope variability in speleothems encodes a range of information about the past environment, although its interpretation is often problematic. U concentration and isotopes have frequently been analysed in speleothems in order to provide chronology, but their use as environmental proxies in their own right has not been comprehensively investigated. In this study, we have investigated the environmental controls of U in a stalagmite from the Central Yangtze Valley in China. This stalagmite grew rapidly throughout the Holocone and contains visible annual layers about 300microns thick. Analysis of a portion of the stalagmite corresponding to the 1970s by electron probe, LA-ICP-MS, and by physical subsampling indicate clear annual cycles in Sr/Ca, Mg/Ca, and Ba/Ca. The reasonably open cave structure and the correlation of Sr/Ca with Mg/Ca suggest that temperature exerts considerable control over these trace element variations. U/Ca also varies seasonally by up to 42 % and shows a clear anti-correlation with Mg/Ca (correlation coefficient -0.64). Based on the inverse relationship between U/Ca and temperature exhibited in other carbonates (e.g. corals) the speleothem U/Ca is suggested to be controlled primarily by temperature and may provide a paleo cave thermometer with less rainfall influence than Mg/Ca. Ongoing monitoring of the cave temperature and humidity will assess the robustness of this conclusion and the sensitivity of speleothem U/Ca to temperature. (234U/238U) in this stalagmite range from 1.733 to 1.872 during the Holocene. The U concentration is high enough (typically 0.48 ppm) and growth rate fast enough, that (234U/238U) can also be measured at a subannual resolution. The expected alpha-recoil control of excess 234U supply suggests that these measurements may provide a measure of the transit time of recharge waters to the stalagmite during the seasonal cycle. Such a proxy would enable deconvolution of temperature and recharge-rate control

7 CFR 51.2541 - U.S. Fancy, U.S. Extra No. 1, U.S. No. 1 And U.S. Select Grades.

Science.gov (United States)

2010-01-01

... PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND STANDARDS) United States Standards for Grades of Pistachio.... Fancy,” “U.S. Extra No. 1,” “U.S. No. 1,” and “U.S. Select” consists of pistachio nuts in the shell...

U.S., U.S.S.R. Marine Expedition

Science.gov (United States)

Wainger, Lisa A.

An historic expedition involving U.S. and U.S.S.R. scientists may open a new era of cooperation in marine research. A University of California, San Diego/Scripps Institution of Oceanography ship carrying a team that includes two Soviet scientists is on an expedition that will take the R/V Thomas Washington into the Exclusive Economic Zone (EEZ) of the U.S.S.R. For the first time in a decade a U.S. research vessel has been given permission to operate in the Soviet Union's EEZ, according to Department of State representative Tom Cocke, who worked with Scripps on this project. The ship will also operate in the U.S. EEZ and international waters.

Informacioni sistemi u upravljanju rizicima u životnoj sredini

Directory of Open Access Journals (Sweden)

Dejan Inđić

2013-02-01

Full Text Available Normal 0 MicrosoftInternetExplorer4 Sažetak: Zemljotresi, poplave, nuklearni i hemijski akcidenti, zagađivanje vazduha, zemljišta i voda, ukazuju na sve veće prisustvo nesreća nastalih intenzivnim razvojem i često nekontrolisanom primenom tehnološkog razvoja. Pred društvo se postavlja problem kako se što bolje pripremiti, kako obezbediti veću usklađenost i funkcionisanje aktivnosti i mera za sprečavanje nastanka akcidentnih situacija i kako uneti promene u društveni i tehnološki razvoj koje će ići u korist prirode, ali i za dobrobit budućih generacija. U radu je prikazano korišćenje različitih informacionih sistema (IS u upravljanju rizicima u životnoj sredini i predlog za izradu jedinstvenog IS u Republici Srbiji.

[Value of immunocytochemistry in differential diagnosis of gastric adenocarcinoma, reactive mesothelial cells and malignant epithelial mesothelioma in metastatic effusion fluid].

Science.gov (United States)

Lyu, M; Cha, N; Zou, Y F; Leng, J H; Xu, L; Sun, Y; Hao, Y Y

2018-03-08

Objective: To investigate the diagnostic value of some antibodies in peritoneal fluid of patients with gastric cancer and malignant epithelioid mesothelioma in serous effusion. Methods: One hundred and eighty-two cases of serous effusion were collected at Jilin Cancer Hospital, from July 2012 to July 2016. The expression of GLUT1, CDX2, Villin, calretinin and WT1 was evaluated using SP immunocytochemical technique in peritoneal fluid samples collected from 98 patients with gastric cancer and 74 patients with reactive mesothelial cells. The expression of GLUT1, calretinin and WT1 was also evaluated in serous effusion from 10 patients with mesothelioma. Results: The sensitivity of GLUT1, CDX2 and Villin in adenocarcinoma cells was 91.8%(90/98), 68.4% (67/98) and 88.8%(87/98), respectively. The specificity was 95.9% (71/74), 100.0%(74/74) and 100.0% (74/74), respectively. The sensitivity of calretinin and WT1 for reactive mesothelium was 93.2% (69/74) and 79.7% (59/74), respectively. The specificity was 96.9% (95/98) and 100.0% (98/98), respectively. The sensitivity of GLUT1, calretinin and WT1 for mesothelioma was 9/10, 9/10 and 7/10. The reactivity of GLUT1, CDX2, Villin, calretinin and WT1 showed a significant difference ( P <0.01) between adenocarcinoma cells and reactive mesothelium. The reactivity of GLUT1 showed a significant difference ( P <0.01) between mesothelioma and reactive mesothelium. Conclusions: The optimal combination is a panel of GLUT1, CDX2, Villin, calretinin and WT1 for differential diagnosis between adenocarcinoma cells and reactive mesothelium in peritoneal fluid of patients with gastric cancer. Whereas GLUT1, calretinin and WT1 is the best for differential diagnosis between reactive mesothelium and mesothelioma in serous effusions.

Theoretical plasma physics: Progress report, January 1, 1987-December 31, 1987

International Nuclear Information System (INIS)

Boozer, A.H.; Vahala, G.; Tracy, E.R.

1987-09-01

During the past year, research has been carried out on current drive in tokamaks and in spheromaks, fast integration techniques for magnetic field lines, alpha particle diagnostics that use CO 2 laser scattering, and plasma turbulence. This paper discusses this research

Kinetics of U(VI) reduction control kinetics of U(IV) reoxidation

International Nuclear Information System (INIS)

Senko, J.M.; Minyard, M.L.; Dempsey, B.A.; Roden, E.E.; Yeh, G.-T.; Burgos, W.D.

2006-01-01

For the in situ reductive immobilization of U to be an acceptable strategy for the removal of that element from groundwater, the long-term stability of U(IV) must be determined. Rates of biotransformation of Fe species influence the mineralogy of the resulting products (Fredrickson et al., 2003; Senko et al., 2005), and we hypothesize that the rate of U(VI) reduction influences the mineralogy of resultant U(IV) precipitates. We hypothesize that slower rates of U(VI) reduction will yield U(IV) phases that are more resistant to reoxidation, and will therefore be more stable upon cessation of electron donor addition. U(IV) phases formed by relatively slow reduction may be more crystalline or larger in comparison to their relatively rapidly-formed counterparts (Figure 1), thus limiting the reactivity of slowly-formed U(IV) phases toward various oxidants. The physical location of U(IV) precipitates relative to bacterial cells may also limit the reactivity of biogenic U(IV) phases. In this situation, we expect that precipitation of U(IV) within the bacterial cell may protect U(IV) from reoxidation by limiting physical contact between U(IV) and oxidants (Figure 1). We assessed the effect of U(VI) reduction rate on the subsequent reoxidation of biogenic U(IV) and are currently conducting column scale studies to determine whether U(VI) reduction rate can be manipulated by varying the electron donor concentration used to stimulate U(VI) reduction

Perspektive promidžbe u XXI. stoljeću

OpenAIRE

Haramija, Predrag; Njavro, Đuro; Propat Darrer, Jagoda

2012-01-01

Otkriće i primjena novih postupaka u promidžbi ovisna je o dvjema vrstama silnica; s jedne strane, o novim tehničkim ili tehnološkim otkrićima glede sredstava komunikacije, a s druge strane o novim situacijama odnosno okolnostima u gospodarskome i društvenom okružju. U radu se prikazuje dosadašnji razvoj i istražuju moguće dominantne tendencije promidžbe u XXI. stoljeću. Početak XXI. stoljeća obilježava zasićenost potrošača mnoštvom promidžbenih poruka i sve veće nepovjerenje u njih, s...

Konstruktivistički pristup obrazovnom postignuću učenika

OpenAIRE

Gutvajn, Nikoleta

2009-01-01

U savremenoj pedagoškoj literaturi, razlike u obrazovnom postignuću učenika se, veomaretko, proučavaju iz perspektive učenika što je, verovatno, jedan od bitnih razloga zakontinuiranu egzistenciju kategorije „neuspešan učenik”. Cilj našeg istraživanja bio je dase problem školskog neuspeha razmotri iz perspektive učenika koji su pozicionirani kaoneuspešni. Umesto mnogobrojnih pretpostavki istraživača o tome zašto su neki učenicineusp...

Operational Characteristics of Liquid Lithium Divertor in NSTX

Science.gov (United States)

Kaita, R.; Kugel, H.; Abrams, T.; Bell, M. G.; Bell, R. E.; Gerhardt, S.; Jaworski, M. A.; Kallman, J.; Leblanc, B.; Mansfield, D.; Mueller, D.; Paul, S.; Roquemore, A. L.; Scotti, F.; Skinner, C. H.; Timberlake, J.; Zakharov, L.; Maingi, R.; Nygren, R.; Raman, R.; Sabbagh, S.; Soukhanovskii, V.

2010-11-01

Lithium coatings on plasma-facing components (PFC's) have resulted in improved plasma performance on NSTX in deuterium H-mode plasmas with neutral beam heating.^ Salient results included improved electron confinement and ELM suppression. In CDX-U, the use of lithium-coated PFC's and a large-area liquid lithium limiter resulted in a six-fold increase in global energy confinement time. A Liquid Lithium Divertor (LLD) has been installed in NSTX for the 2010 run campaign. The LLD PFC consists of a thin film of lithium on a temperature-controlled substrate to keep the lithium liquefied between shots, and handle heat loads during plasmas. This capability was demonstrated when the LLD withstood a strike point on its surface during discharges with up to 4 MW of neutral beam heating.

Online Manufacturing Training. ToolingU Review (U)

Energy Technology Data Exchange (ETDEWEB)

Montano, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-03-23

The following report is a review of ToolingU, an online manufacturing training website. ToolingU provided the author with a trail account where a number of courses were taken and the overall program was evaluated. A review of the classes revealed that most of the offerings directly align with work at the Laboratory. Ease of use, effectiveness of the system and price all make ToolingU an attractive option for manufacturing training needs.

Contribution to the study of U-Ti and U-Pu-Ti carbides; Contribution a l'etude des carbures U-C-Ti et (U, Pu) - C-Ti

Energy Technology Data Exchange (ETDEWEB)

Milet, C A [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1968-07-01

After having discussed the reasons to use (U,Pu) carbides as fast reactor fuel, we examine the influence of the addition of titanium to these carbides. A preliminary study has been done on the system of U-C-Ti and some properties have been measured such as: density, thermal expansion, electrical resistivity, atmospheric corrosion and compatibility with stainless steel. The systems U-Pu-C-Ti (Pu/U + Pu equal to 15 per cent) and U-C-Ti have been found to be very similar. There exists a two phases region (U,Pu)C + TiC, an eutectic between (U,Pu)C and TiC for approximately 15 at %. The solubilities of U + Pu in TiC and of Ti in (U,Pu)C is less than 1 % at. The addition of titanium does not markedly change thermal expansion coefficients of (U,Pu)C. However the resistance to atmospheric corrosion and compatibility with stainless steel is improved. Thermal conductivity, calculated from electrical resistivity, has increased. On the other side, the density of fissile material is lowered. The combination of (U,Pu)C + TiC seems to be the most promising alloy for application as nuclear fuel. (author) [French] Apres avoir rappele les problemes poses par un combustible pour les reacteurs a neutrons rapides et l'interet des carbures U-Pu-C comme combustible, on examine l'influence de l'addition de titane dans ces carbures. Une etude preliminaire sur le systeme U-C-Ti a ete effectuee et quelques proprietes sont indiquees: densite, coefficients de dilatation, resistivite electrique, tenue a la corrosion atmospherique, compatibilite avec l'acier inoxydable. Le systeme U-Pu-C-Ti (Pu/U + Pu egal a 15 pour cent) presente de grandes analogies avec le systeme U-C-Ti. Il existe un domaine biphase (U,Pu)C + TiC, un eutectique entre (U,Pu)C et TiC pour environ 15 at % Ti; les solubilites de U + Pu clans TiC et de Ti dans (U,Pu)C sont inferieures a 1 at %. Par rapport a la phase (U,Pu)C, l'addition de titane est sans effets importants sur les coefficients de dilatation. Par contre la tenue a

Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis.

Directory of Open Access Journals (Sweden)

Aseervatham Anusha Amali

Full Text Available Mice lacking the 4th-group paralog Hoxd4 display malformations of the anterior vertebral column, but are viable and fertile. Here, we report that zebrafish embryos having decreased function of the orthologous hoxd4a gene manifest striking perturbations in vasculogenesis, angiogenesis and primitive and definitive hematopoiesis. These defects are preceded by reduced expression of the hemangioblast markers scl1, lmo2 and fli1 within the posterior lateral plate mesoderm (PLM at 13 hours post fertilization (hpf. Epistasis analysis revealed that hoxd4a acts upstream of meis1.1 but downstream of cdx4 as early as the shield stage in ventral-most mesoderm fated to give rise to hemangioblasts, leading us to propose that loss of hoxd4a function disrupts hemangioblast specification. These findings place hoxd4a high in a genetic hierarchy directing hemangioblast formation downstream of cdx1/cdx4 and upstream of meis1.1. An additional consequence of impaired hoxd4a and meis1.1 expression is the deregulation of multiple Hox genes implicated in vasculogenesis and hematopoiesis which may further contribute to the defects described here. Our results add to evidence implicating key roles for Hox genes in their initial phase of expression early in gastrulation.

Generalized helicity and its time derivative

International Nuclear Information System (INIS)

Jarboe, T.R.; Marklin, G.J.

1985-01-01

Spheromaks can be sustained against resistive decay by helicity injection because they tend to obey the minimum energy principle. This principle states that a plasma-laden magnetic configuration will relax to a state of minimum energy subject to the constraint that the magnetic helicity is conserved. Use of helicity as a constraint on the minimization of energy was first proposed by Woltjer in connection with astrophysical phenomena. Helicity does decay on the resistive diffusion time. However, if helicity is created and made to flow continuoiusly into a confinement geometry, these additional linked fluxes can relax and sustain the configuration indefinitely against the resistive decay. In this paper we will present an extension of the definition of helicity to include systems where B vector can penetrate the boundary and the penetration can be varying in time. We then discuss the sustainment of RFPs and spheromaks in terms of helicity injection

77 FR 47169 - Clearing Requirement Determination Under Section 2(h) of the CEA

Science.gov (United States)

2012-08-07

... cleared through central counterparties and traded on exchanges or electronic trading platforms, where... Yield (consisting of 100 high yield corporate reference entities) (CDX.NA.HY). The standard currency for...

Neutron inelastic-scattering cross sections of 232Th, 233U, 235U, 238U, 239Pu and 240Pu

International Nuclear Information System (INIS)

Smith, A.B.; Guenther, P.T.

1982-01-01

Differential-neutron-emission cross sections of 232 Th, 233 U, 235 U, 238 U, 239 Pu and 240 Pu are measured between approx. = 1.0 and 3.5 MeV with the angle and magnitude detail needed to provide angle-integrated emission cross sections to approx. 232 Th, 233 U, 235 U and 238 U inelastic-scattering values, poor agreement is observed for 240 Pu, and a serious discrepancy exists in the case of 239 Pu

Analysis of 235U enrichment by chemical exchange in U(IV) - U(VI) system on anionite

International Nuclear Information System (INIS)

Raica, Paula; Axente, Damian

2007-01-01

Full text: A theoretical study about the 235 U enrichment by chemical exchange method in U(IV)-U(VI) system on anion-exchange resins is presented. The 235 U isotope concentration profiles along the band were numerically calculated using an accurate mathematical model and simulations were carried out for the situation of product and waste withdrawal and feed supply. By means of numerical simulation, an estimation of the migration time, necessary for a desired enrichment degree, was obtained. The required migration distance, the production of uranium 3 at.% 235 U per year and the plant configuration are calculated for different operating conditions. An analysis of the process scale for various experimental conditions is also presented. (authors)

Princeton Plasma Physics Laboratory annual report, October 1, 1984-September 30, 1985

International Nuclear Information System (INIS)

Phillips, C.A.

1985-01-01

Summaries of research progress during this period are given for the following areas: (1) TFTR, (2) PLT, (3) PBX, (4) S-1 Spheromak, (5) Advanced Concepts Torus-1, (6) x-ray laser studies, (7) theory, (8) tokamak modeling, (9) spin-polarization, and (10) ignition studies

Anomalous isotope effects in the U(IV)-U(VI) exchange system

International Nuclear Information System (INIS)

Fujii, Yasuhiko; Nomura, Masao; Okamoto, Makoto; Onitsuka, Hatsuki; Nakanishi, Takashi.

1992-01-01

In previous papers, the enrichment of 236 U in the U(IV) - U(VI) chemical exchange system was found to be significantly smaller than the value estimated by the normal mass dependence enrichment of 235 U. Further experiments have been carried out in the present work to confirm the strange phenomenon of the isotopic anomaly in uranium enrichment. The results have indicated that the separation coefficient of 236 U is the same value as one previously reported. To confirm the anomaly of uranium isotope separation, α-ray spectrometry was implemented to check the enrichment behavior of 234 U. Although no theoretical explanation is given for the isotopic anomaly, this is favorable phenomenon for the re-enrichment of recycled uranium which contains isotopes 232 U and 236 U. (author)

Vector coherent state representations of SO5 contains SU2 + SU2 contains U1 + U1 and SO5 contains U1 + U1

International Nuclear Information System (INIS)

Pan Feng

1991-01-01

VCS representations of SO 5 contains SU 2 + SU 2 contains U 1 + U 1 and SO 5 contains U 1 + U 1 are discussed. Reduced matrix elements for SO 5 contains SU 2 + SU 2 are derived. The multiplicity of a weight for SO 5 is determined by using the K-matrix technique

Thermodynamic modeling of the Al-U and Co-U systems

International Nuclear Information System (INIS)

Wang, J.; Liu, X.J.; Wang, C.P.

2008-01-01

The thermodynamic assessments of the Al-U and Co-U systems have been carried out by using the CALPHAD (Calculation of Phase Diagrams) method on the basis of the experimental data including thermodynamic properties and phase equilibria. Gibbs free energies of the solution phases were described by the subregular solution models with the Redlich-Kister equation, and those of the intermetallic compounds described by the sublattice models. A consistent set of thermodynamic parameters has been derived for describing the Gibbs free energies of each solution phase and intermetallic compounds in the Al-U and Co-U binary systems. The calculated phase diagrams and thermodynamic properties in the Al-U and Co-U systems are in good agreement with experimental data

Odnos između ortodontskih i izgovornih poremećaja u adolescenata

OpenAIRE

Hunski, M.; Ivičević-Desnica, J.; Škarić, I.; Horga, D.

2003-01-01

Različita su istraživanja pokazala da je broj izgovornih poremećaja veći u populaciji s ortodontskim anomalijama nego u osoba bez njih. Odnos između anatomskih struktura u orofacijalnoj regiji i izgovornih kompenzacijskih mehanizama u osoba s ortodontskim anomalijama zanimljiv je i s teoretskoga i s praktičnoga stajališta. U ovom je istraživanju na uzorku od 282 srednjoškolca (203 - 72% djevojaka i 79 - 28% dječaka) u dobi od 15 do 18 godina istražen odnos između ortodontskih i izgovornih por...

In-pile test results of U-silicide or U-nitride coated U-7Mo particle dispersion fuel in Al

Science.gov (United States)

Kim, Yeon Soo; Park, J. M.; Lee, K. H.; Yoo, B. O.; Ryu, H. J.; Ye, B.

2014-11-01

U-silicide or U-nitride coated U-Mo particle dispersion fuel in Al (U-Mo/Al) was in-pile tested to examine the effectiveness of the coating as a diffusion barrier between the U-7Mo fuel kernels and Al matrix. This paper reports the PIE data and analyses focusing on the effectiveness of the coating in terms of interaction layer (IL) growth and general fuel performance. The U-silicide coating showed considerable success, but it also provided evidence for additional improvement for coating process. The U-nitride coated specimen showed largely inefficient results in reducing IL growth. From the test, important observations were also made that can be utilized to improve U-Mo/Al fuel performance. The heating process for coating turned out to be beneficial to suppress fuel swelling. The use of larger fuel particles confirmed favorable effects on fuel performance.

In-pile test results of U-silicide or U-nitride coated U-7Mo particle dispersion fuel in Al

Energy Technology Data Exchange (ETDEWEB)

Kim, Yeon Soo, E-mail: yskim@anl.gov [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Park, J.M.; Lee, K.H.; Yoo, B.O. [Korea Atomic Energy Research Institute, 989-111 Daedeokdaero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Ryu, H.J. [Dept. of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Ye, B. [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States)

2014-11-15

U-silicide or U-nitride coated U-Mo particle dispersion fuel in Al (U-Mo/Al) was in-pile tested to examine the effectiveness of the coating as a diffusion barrier between the U-7Mo fuel kernels and Al matrix. This paper reports the PIE data and analyses focusing on the effectiveness of the coating in terms of interaction layer (IL) growth and general fuel performance. The U-silicide coating showed considerable success, but it also provided evidence for additional improvement for coating process. The U-nitride coated specimen showed largely inefficient results in reducing IL growth. From the test, important observations were also made that can be utilized to improve U-Mo/Al fuel performance. The heating process for coating turned out to be beneficial to suppress fuel swelling. The use of larger fuel particles confirmed favorable effects on fuel performance.

Assay of Uranium Isotopic Ratios 234U/238U, 235U/238U in Bottom Sediment Samples Using Destructive and Non Destructive Techniques (Nasser Lake)

International Nuclear Information System (INIS)

Agha, A.R.; El-Mongy, S.A.; Kandel, A.E.

2011-01-01

Nasser Lake is the greatest man-made lake in the World. It is considered as the main source of water where the Nile water is impounded behind the Aswan high dam.. Uranium has three naturally occurring isotopes 234 U, 235 U and 238 U with isotopic abundance 0.00548, 0.7200 and 99.2745 atom percent. Dissolved uranium in the lake is primary due to weathering process. Monitoring of the isotopic ratios of uranium is used as a good indicator to trace and evaluate the origin and activities associated with any variation of uranium in the lake environment. The main objective of the present study is to clarify any potential variation of natural uranium 234 U/ 238 U, 235 U/ 238 U ratios in sediment samples of Nasser Lake by using destructive alpha and non destructive gamma- techniques. The results show that the uranium isotopic activity ratios are very close to the natural values. This study can also be used for radiological protection and safety evaluation purposes.

A mixed-valent uranium phosphonate framework containing U{sup IV}, U{sup V}, and U{sup VI}

Energy Technology Data Exchange (ETDEWEB)

Chen, Lanhua; Zheng, Tao; Wang, Yaxing; Diwu, Juan; Chai, Zhifang; Wang, Shuao [School for Radiological and interdisciplinary Sciences (RAD-X), Soochow University, Suzhou (China); Collaborative Innovation Center of Radiation Medicine, Jiangsu Higher Education Institutions, Suzhou (China); Bao, Songsong; Zheng, Limin [State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University (China); Zhang, Linjuan; Wang, Jianqiang [Shanghai Institute of Applied Physics and, Key Laboratory of Nuclear Radiation and Nuclear Energy Technology, Chinese Academy of Sciences, Shanghai (China); Liu, Hsin-Kuan [Department of Chemistry, National Central University, Jhongli (China); Albrecht-Schmitt, Thomas E. [Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL (United States)

2016-08-16

It is shown that U{sup V}O{sub 2}{sup +} ions can reside at U{sup VI}O{sub 2}{sup 2+} lattice sites during mild reduction and crystallization process under solvothermal conditions, yielding a complicated and rare mixed-valent uranium phosphonate compound that simultaneously contains U{sup IV}, U{sup V}, and U{sup VI}. The presence of uranium with three oxidation states was confirmed by various characterization techniques, including X-ray crystallography, X-ray photoelectron, electron paramagnetic resonance, FTIR, UV/Vis-NIR absorption, and synchrotron radiation X-ray absorption spectroscopy, and magnetism measurements. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Measurement of 233U/234U ratios in contaminated groundwater using alpha spectrometry

International Nuclear Information System (INIS)

Harrison, Jennifer J.; Payne, Timothy E.; Wilsher, Kerry L.; Thiruvoth, Sangeeth; Child, David P.; Johansen, Mathew P.; Hotchkis, Michael A.C.

2016-01-01

The uranium isotope 233 U is not usually observed in alpha spectra from environmental samples due to its low natural and fallout abundance. It may be present in samples from sites in the vicinity of nuclear operations such as reactors or fuel reprocessing facilities, radioactive waste disposal sites or sites affected by clandestine nuclear operations. On an alpha spectrum, the two most abundant alpha emissions of 233 U (4.784 MeV, 13.2%; and 4.824 MeV, 84.3%) will overlap with the 234 U doublet peak (4.722 MeV, 28.4%; and 4.775 MeV, 71.4%), if present, resulting in a combined 233+234 U multiplet. A technique for quantifying both 233 U and 234 U from alpha spectra was investigated. A series of groundwater samples were measured both by accelerator mass spectrometry (AMS) to determine 233 U/ 234 U atom and activity ratios and by alpha spectrometry in order to establish a reliable 233 U estimation technique using alpha spectra. The Genie™ 2000 Alpha Analysis and Interactive Peak Fitting (IPF) software packages were used and it was found that IPF with identification of three peaks ( 234 U minor, combined 234 U major and 233 U minor, and 233 U major) followed by interference correction on the combined peak and a weighted average activity calculation gave satisfactory agreement with the AMS data across the 233 U/ 234 U activity ratio range (0.1–20) and 233 U activity range (2–300 mBq) investigated. Correlation between the AMS 233 U and alpha spectrometry 233 U was r 2  = 0.996 (n = 10). - Highlights: • Describes a technique for deconvoluting the combined 233 U and 234 U multiplet in alpha spectra. • Enables 233 U and 234 U activities and 233 U/ 234 U ratios to be quantified without requiring additional analysis and measurement. • Applicable to an environmental matrix (groundwater) using standard alpha spectrometry counting equipment, operation and set-up.

Seawater 234U/238U recorded by modern and fossil corals

Science.gov (United States)

Chutcharavan, Peter M.; Dutton, Andrea; Ellwood, Michael J.

2018-03-01

U-series dating of corals is a crucial tool for generating absolute chronologies of Late Quaternary sea-level change and calibrating the radiocarbon timescale. Unfortunately, coralline aragonite is susceptible to post-depositional alteration of its primary geochemistry. One screening technique used to identify unaltered corals relies on the back-calculation of initial 234U/238U activity (δ234Ui) at the time of coral growth and implicitly assumes that seawater δ234U has remained constant during the Late Quaternary. Here, we test this assumption using the most comprehensive compilation to date of coral U-series measurements. Unlike previous compilations, this study normalizes U-series measurements to the same decay constants and corrects for offsets in interlaboratory calibrations, thus reducing systematic biases between reported δ234U values. Using this approach, we reassess (a) the value of modern seawater δ234U, and (b) the evolution of seawater δ234U over the last deglaciation. Modern coral δ234U values (145.0 ± 1.5‰) agree with previous measurements of seawater and modern corals only once the data have been normalized. Additionally, fossil corals in the surface ocean display δ234Ui values that are ∼5-7‰ lower during the last glacial maximum regardless of site, taxon, or diagenetic setting. We conclude that physical weathering of U-bearing minerals exposed during ice sheet retreat drives the increase in δ234U observed in the oceans, a mechanism that is consistent with the interpretation of the seawater Pb-isotope signal over the same timescale.

Photochemistry of U(BH4)4 and U(BD4)4

International Nuclear Information System (INIS)

Paine, R.T.; Schonberg, P.R.; Light, R.W.; Danen, W.C.; Freund, S.M.

1979-01-01

U(BH 4 ) 4 and U(BD 4 ) 4 are observed to undergo complex degradation reactions promoted by broadband UV radiation. The primary products of these reactions appear to be U(BH 4 ) 3 , B 2 H 6 , H 2 , U(BD 4 ) 3 , B 2 D 6 and D 2 . Further, U(BD 4 ) 4 undergoes a related decomposition reaction under the influence of CO 2 laser irradiation at 924.97 cm -1 . (author)

Supersymmetric U boson and the old U(1) problem

International Nuclear Information System (INIS)

Kim, B.R.

1983-01-01

In the supersymmetric SU(3)xSU(2)xU(1)xUsup(')(1) model the new gauge group Usup(')(1) enforces the introduction of mirror fermions. In this note we address the inverse question. If one starts with SU(3)xSU(2)xU(1) including mirror fermions, what physical arguments other than the supersymmetric require the introduction of a new gauge group Usup(')(1). It turns out that the old U(1) problem is closely related with this question. Further we give an estimate for the upper bound for the parameter of the supersymmetric U boson r and x. (orig.)

Review of recent experiments on magnetic reconnection in laboratory plasmas

International Nuclear Information System (INIS)

Yamada, M.

1995-02-01

The present paper reviews recent laboratory experiments on magnetic reconnection. Examples will be drawn from electron current sheet experiments, merging spheromaks, and from high temperature tokamak plasmas with the Lundquist numbers exceeding 10 7 . These recent laboratory experiments create an environment which satisfies the criteria for MHD plasma and in which the global boundary conditions can be controlled externally. Experiments with fully three dimensional reconnection are now possible. In the most recent TFTR tokamak discharges, Motional Stark effect (MSE) data have verified the existence of a partial reconnection. In the experiment of spheromak merging, a new plasma acceleration parallel to the neutral line has been indicated. Together with the relationship of these observations to the analysis of magnetic reconnection in space and in solar flares, important physics issues such as global boundary conditions, local plasma parameters, merging angle of the field lines, and the 3-D aspects of the reconnection are discussed

Nonlinear electron magnetohydrodynamics physics. IV. Whistler instabilities

International Nuclear Information System (INIS)

Urrutia, J. M.; Stenzel, R. L.; Strohmaier, K. D.

2008-01-01

A very large low-frequency whistler mode is excited with magnetic loop antennas in a uniform laboratory plasma. The wave magnetic field exceeds the ambient field causing in one polarity a field reversal, and a magnetic topology resembling that of spheromaks in the other polarity. These propagating ''whistler spheromaks'' strongly accelerate the electrons and create non-Maxwellian distributions in their toroidal current ring. It is observed that the locally energized electrons in the current ring excite new electromagnetic instabilities and emit whistler modes with frequencies unrelated to the applied frequency. Emissions are also observed from electrons excited in X-type neutral lines around the antenna. The properties of the excited waves such as amplitudes, frequency spectra, field topologies, propagation, polarization, growth, and damping have been investigated. The waves remain linear (B wave 0 ) and convert a small part of the electron kinetic energy into wave magnetic energy (B wave 2 /2μ 0 e )

Application of Coaxial Ion Gun for Film Generation and Ion Implantation

Science.gov (United States)

Takatsu, Mikio; Asai, Tomohiko; Kurumi, Satoshi; Suzuki, Kaoru; Hirose, Hideharu; Masutani, Shigeyuki

A magnetized coaxial plasma gun (MCPG) is here utilized for deposition on high-melting-point metals. MCPGs have hitherto been studied mostly in the context of nuclear fusion research, for particle and magnetic helicity injection and spheromak formation. During spheromak formation, the electrode materials are ionized and mixed into the plasmoid. In this study, this ablation process by gun-current sputtering is enhanced for metallic thin-film generation. In the proposed system geometry, only ionized materials are electromagnetically accelerated by the self-Lorentz force, with ionized operating gas as a magnetized thermal plasmoid, contributing to the thin-film deposition. This reduces the impurity and non-uniformity of the deposited thin-film. Furthermore, as the ions are accelerated in a parallel direction to the injection axis, vertical implantation of the ions into the substrate surface is achieved. To test a potential application of the developed system, experiments were conducted involving the formation of a buffer layer on hard ceramics, for use in dental materials.

Recent results from the HIT-II and HIT-SI helicity injection current drive experiments

International Nuclear Information System (INIS)

Jarboe, T.R.; Hamp, W.T.; Izzo, V.A.; Nelson, B.A.; O'Neill, R.G.; Raman, R.; Redd, A.J.; Sieck, P.E.; Smith, R.J.

2005-01-01

Three important results are reported. 1) CHI startup has produced 100 kA of closed current without using poloidal field (PF) coils or any transformer action. The initial equilibrium is then driven to 240 kA with a 3 V transformer loop voltage, indicating high quality plasma. 2) For the first time CHI alone has produced toroidal currents (350 kA) that far exceed q a I inj , and with I p /I tf as high as 1.2. The key to these new results appears to be having the toroidal field small enough that relaxation will occur. 3) The steady inductive helicity injection spheromak experiment has operated at 5 kHz for 6 ms with current amplitudes up to 11 kA in each injector. The helicity injection rate is nearly constant with the ExB flow always into the plasma and not into the walls. NIMROD simulations of HIT-SI show a buildup of spheromak fields. (author)

Merging formation of FRC and its application to high-beta ST formation

International Nuclear Information System (INIS)

Ono, Y.; Inomoto, M.; Ueda, Y.; Matsuyama, T.; Ohshima, Y.; Katsurai, M.

2001-01-01

Merging formation of field-reversed configuration (FRC) explored not only a new scenario of highly-efficient FRC formation/amplification experiment but also a new boundary research between FRC, spheromak and spherical tokamak (ST). A new finding is that the produced FRC is transformed stably into an ultra-high-β ST by applying external toroidal field B t,ext . The toroidal field was observed to vanish around magnetic axis after the B t,ext application to the FRC, indicating formation of diamagnetic ST. The hollow current profile of FRC was maintained during the equilibrium transition, eliminating a need for the difficult hollow-current-formation process of start-up discharge of high-β ST. The energy-conversion effect of merging transformed the force-free merging spheromaks with paramagnetic current into the FRC with diamagnetic current and the further application of B t,ext did the FRC into the ultra-high-β (>60%)/diamagnetic ST, indicating the close relationship between FRC and ST in second stability. (author)

Evolucija softvera u Turskoj

OpenAIRE

Mishra, Alok; Yazici, Ali; Cetin, Semih

2016-01-01

Prema zadnjem izvještaju Gartnera, Turska se sada treba uzeti u obzir jer si je osigurala mjesto među 30 vodećih zemalja na svijetu u području inormacijske tehnologije (IT) i inozemnih usluga. Tijekom zadnjeg desetljeća postignut je izvanredan napredak u području izrade kompjutorskih programa, a to je rezultiralo porastom izvoza u mnoge zemlje. U ovom radu dajemo pregled pomaka koji je Turska učinila u izradi programa, uključujući postojeće trendove, ispitivanja, kvalitetu i prihvaćanje agiln...

Contribution to the study of U-Ti and U-Pu-Ti carbides

International Nuclear Information System (INIS)

Milet, C.A.

1968-01-01

After having discussed the reasons to use (U,Pu) carbides as fast reactor fuel, we examine the influence of the addition of titanium to these carbides. A preliminary study has been done on the system of U-C-Ti and some properties have been measured such as: density, thermal expansion, electrical resistivity, atmospheric corrosion and compatibility with stainless steel. The systems U-Pu-C-Ti (Pu/U + Pu equal to 15 per cent) and U-C-Ti have been found to be very similar. There exists a two phases region (U,Pu)C + TiC, an eutectic between (U,Pu)C and TiC for approximately 15 at %. The solubilities of U + Pu in TiC and of Ti in (U,Pu)C is less than 1 % at. The addition of titanium does not markedly change thermal expansion coefficients of (U,Pu)C. However the resistance to atmospheric corrosion and compatibility with stainless steel is improved. Thermal conductivity, calculated from electrical resistivity, has increased. On the other side, the density of fissile material is lowered. The combination of (U,Pu)C + TiC seems to be the most promising alloy for application as nuclear fuel. (author) [fr

All Small Nuclear RNAs (snRNAs) of the [U4/U6.U5] Tri-snRNP Localize to Nucleoli; Identification of the Nucleolar Localization Element of U6 snRNA

Science.gov (United States)

Gerbi, Susan A.; Lange, Thilo Sascha

2002-01-01

Previously, we showed that spliceosomal U6 small nuclear RNA (snRNA) transiently passes through the nucleolus. Herein, we report that all individual snRNAs of the [U4/U6.U5] tri-snRNP localize to nucleoli, demonstrated by fluorescence microscopy of nucleolar preparations after injection of fluorescein-labeled snRNA into Xenopus oocyte nuclei. Nucleolar localization of U6 is independent from [U4/U6] snRNP formation since sites of direct interaction of U6 snRNA with U4 snRNA are not nucleolar localization elements. Among all regions in U6, the only one required for nucleolar localization is its 3′ end, which associates with the La protein and subsequently during maturation of U6 is bound by Lsm proteins. This 3′-nucleolar localization element of U6 is both essential and sufficient for nucleolar localization and also required for localization to Cajal bodies. Conversion of the 3′ hydroxyl of U6 snRNA to a 3′ phosphate prevents association with the La protein but does not affect U6 localization to nucleoli or Cajal bodies. PMID:12221120

Formation Dirac point and the topological surface states for HgCdTe-QW and mixed 3D HgCdTe TI

Science.gov (United States)

Marchewka, Michał

2017-01-01

In this paper the results of numerical calculations based on the finite difference method (FDM) for the 2D and 3D TI with and without uniaxial tensile strain for mixed Hg1-xCdxTe structures are presented. The numerical calculations were made using the 8×8 model for x from 0 up to 0.155 and for the wide range for the thickness from a few nm for 2D up to 150 nm for 3D TI as well as for different mismatch of the lattice constant and different barrier potential in the case of the QW. For the investigated region of the Cd composition (x value) the negative energy gap (Eg=Γ8-Γ6) in the Hg1-xCdxTe is smaller than in the case of pure HgTe which, as it turns out, has a significant influence on the topological surface states (TSS) and the position of the Dirac point for QW as well as for 3D TI. The results show that the strained gap and the position of the Dirac point against the Γ8 is a function of the x-Cd compounds in the case of the 3D TI as well as the critical width of the mixed Hg1-xCdxTe QW.

Razlika između klasične i keynesijanske ekonomske doktrine u 20. stoljeću s implikacijama na hrvatsku tranziciju

OpenAIRE

Brumec, Dino

2017-01-01

U dvadeseto stoljeće svijet je ušao s nepoljuljanom vjerom u snagu slobodnog tržišta koje će regulirati odnose među ljudima na svakoj razini. Prvi znanstvenik koji se suprostavio toj vjeri na jasno strukturiran način bio je John Maynard Keynes koji je ponudio državi doktrinu u kojoj njeno djelovanje ima velik prostor te je u vrlo kratkom roku postao najutjecajniji ekonomist na svijetu. Nasuprot njemu stajao je Friedrich Hayek koji je državi nudio mnogo manje utjecaja u gos...

Istraživanje virusnih bolesti u nekih slatkovodnih riba u Republici Kosovo.

OpenAIRE

Rexhepi, Agim; Bërxholi, Kristaq; Scheinert, Peter; Hamidi, Afrim; Sherifi, Kurtesh

2011-01-01

U radu je istražena prisutnost virusne hemoragijske septikemije, zarazne hematopoetske nekroze i zarazne nekroze gušterače u potočne pastrve te proljetne viremije šarana u šarana i bijelog glavaša na Kosovu. Uzeti materijal bio je pretražen RT-PCR-om i ugniježđenim PCR-om u laboratoriju službe za životinjsko zdravlje u Münchenu u Njemačkoj. Uzorci šarana i bijeloga glavaša bili su prikupljeni na šaranskom ribnjačarstvu, na jezeru i rijeci, a uzorci potočne pastrve na pet rijeka. U razdoblju o...

U-Shaped Interest in U-Shaped Development--and What It Means

Science.gov (United States)

Siegler, Robert S.

2004-01-01

Interest in U-shaped development has itself undergone a U-shaped progression. Twenty-five years ago, interest in U-shaped development was high. This interest was evident at a 1978 conference in Tel Aviv on "U-shaped Behavioral Growth" that resulted in the publication of a book of the same title 4 years later (Strauss, 1982). The breadth…

77 FR 29636 - Environmental Impacts Statements; Notice of Availability

Science.gov (United States)

2012-05-18

...: https://cdx.epa.gov . EIS No. 20120146, Final EIS, USFS, OR, Jackson Vegetation Management Project... Period Ends: 07/02/2012, Contact: Michael Barnette 727-824-5312. EIS No. 20120154, Final EIS, USFWS, MT...

Proceedings of the third symposium on the physics and technology of compact toroids in the magnetic fusion energy program

International Nuclear Information System (INIS)

Siemon, R.E.

1981-03-01

This document contains papers contributed by the participants of the Third Symposium on Physics and Technology of Compact Toroids in the Magnetic Fusion Energy Program. Subjects include reactor aspects of compact toroids, energetic particle rings, spheromak configurations (a mixture of toroidal and poloidal fields), and field-reversed configurations

Usne u lavi

Directory of Open Access Journals (Sweden)

Una Krizmanić Ožegović

2017-06-01

Full Text Available [...] opatica je žena, ali žena koju se ne vidi svaki dan. Muškarci je se ne mogu nauživati u svakodnevnom ophođenju, stoga je žele s još većim žarom, skrivena je, zakukuljena, odsječena od svijeta u samostanu, u zatvoru, u beskrajnom zdanju u kojem se iza svakih vrata skrivaju još jedna. Carlos Fuentes, Constancia i druge priče za djeviceBože, oprosti mi. Možeš razumjeti silnu mahnitost u mojim prstima, vulkansku i suspregnutu potrebu mojih usana, vrelinu, i, o moj Bože, miris. Mnoštvo mirisa, otporne dlačice, znoj, znoj, prosta ruka, neobuzdana, poremećena, gruba. Gruba ruka kreće se u rupi, u kaljuži mojega bića. Svjedok – noć: pozornica za nasuprotnosti, noge i raskriljene proscenije, predstava uživo odakle se mrijeste strašne sablasti. Hitnem se s vrhunca svoje vjere, tijelo mi se razvaljuje u prah: prah koji se slobodno kreće, prah koji živi, prah koji je daleko od tebe, Gospodine. Jer griješim s golemim užitkom! I griješim misleći oživjeti. Gospodine, ja umirem od užitka u rukama, jezik traži ono što ne može dodirnuti, slina curi preko otvora; stenjem od trenja grješnih ruku, stenjem, vapim nijemo, ne da bih ti protuslovila, stenjem ne bih li te spoznala; pripojila. Svaka moja pora mjesto je otvorena dijaloga – začepljena znojem i magijom, bludi i slinom. Ruke, nezaustavljive, diraju mi kožu, rupe, mrse dlačice, prodiru divlje kao da nisam ni svoja, ni njihova gospodarica. Ruke puštaju da po njima curi slina s kojom prvo nisam znala što bih, onda sam je prisvojila, pa poslije tražila u iskusnu ritmu. Slina, proziran mulj, nedolično teče iz duše, predaje me na milost noći i mene same, curi, širi se prema netaknutim otvorima, olakšava mi pristup uskim, zabranjenim prolazima, Gospodine. Jer nastojala sam biti, bila sam u zabranjenim i uskim prolazima; zato griješim, Gospodine: s glazbom koja mi klizi niz dušu, s mutnom slinom, obilatom, demonskom, kola mi utrobom, prodire mirisom, miluje

Tank 241-U-102, Grab Samples 2U-99-1, 2U-99-2 and 2U-99-3 Analytical Results for the Final Report

International Nuclear Information System (INIS)

STEEN, F.H.

1999-01-01

This document is the final report for tank 241-U-102 grab samples. Five grab samples were collected from riser 13 on May 26, 1999 and received by the 222-S laboratory on May 26 and May 27, 1999. Samples 2U-99-3 and 2U-99-4 were submitted to the Process Chemistry Laboratory for special studies. Samples 2U-99-1, 2U-99-2 and 2U-99-5 were submitted to the laboratory for analyses. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan for Fiscal year 1999 (TSAP) (Sasaki, 1999) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Fowler 1995, Mulkey and Miller 1998). The analytical results are presented in the data summary report. None of the subsamples submitted for differential scanning calorimetry (DSC), total organic carbon (TOC) and plutonium 239 (Pu239) analyses exceeded the notification limits as stated in TSAP

Master formula approach to broken chiral U(3)xU(3) symmetry

Energy Technology Data Exchange (ETDEWEB)

Hiroyuki Kamano

2010-04-01

The master formula approach to chiral symmetry breaking proposed by Yamagishi and Zahed is extended to the U_R(3)xU_L(3) group, in which effects of the U_A(1) anomaly and the flavor symmetry breaking m_u \

U(1) x U(1) x U(1) symmetry of the Kimura 3ST model and phylogenetic branching processes

International Nuclear Information System (INIS)

Bashford, J D; Jarvis, P D; Sumner, J G; Steel, M A

2004-01-01

An analysis of the Kimura 3ST model of DNA sequence evolution is given on the basis of its continuous Lie symmetries. The rate matrix commutes with a U(1) x U(1) x U(1) phase subgroup of the group GL(4) of 4 x 4 invertible complex matrices acting on a linear space spanned by the four nucleic acid base letters. The diagonal 'branching operator' representing speciation is defined, and shown to intertwine the U(1) x U(1) x U(1) action. Using the intertwining property, a general formula for the probability density on the leaves of a binary tree under the Kimura model is derived, which is shown to be equivalent to established phylogenetic spectral transform methods. (letter to the editor)

A Challenging Solar Eruptive Event of 18 November 2003 and the Causes of the 20 November Geomagnetic Superstorm. III. Catastrophe of the Eruptive Filament at a Magnetic Null Point and Formation of an Opposite-Handedness CME

Science.gov (United States)

Uralov, A. M.; Grechnev, V. V.; Rudenko, G. V.; Myshyakov, I. I.; Chertok, I. M.; Filippov, B. P.; Slemzin, V. A.

2014-10-01

Our analysis in Papers I and II (Grechnev et al., Solar Phys. 289, 289, 2014b and Solar Phys. 289, 1279, 2014c) of the 18 November 2003 solar event responsible for the 20 November geomagnetic superstorm has revealed a complex chain of eruptions. In particular, the eruptive filament encountered a topological discontinuity located near the solar disk center at a height of about 100 Mm, bifurcated, and transformed into a large cloud, which did not leave the Sun. Concurrently, an additional CME presumably erupted close to the bifurcation region. The conjectures about the responsibility of this compact CME for the superstorm and its disconnection from the Sun are confirmed in Paper IV (Grechnev et al., Solar Phys. submitted, 2014a), which concludes about its probable spheromak-like structure. The present article confirms the presence of a magnetic null point near the bifurcation region and addresses the origin of the magnetic helicity of the interplanetary magnetic clouds and their connection to the Sun. We find that the orientation of a magnetic dipole constituted by dimmed regions with the opposite magnetic polarities away from the parent active region corresponded to the direction of the axial field in the magnetic cloud, while the pre-eruptive filament mismatched it. To combine all of the listed findings, we propose an intrinsically three-dimensional scheme, in which a spheromak-like eruption originates via the interaction of the initially unconnected magnetic fluxes of the eruptive filament and pre-existing ones in the corona. Through a chain of magnetic reconnections their positive mutual helicity was transformed into the self-helicity of the spheromak-like magnetic cloud.

Measurement of the 235U/238U fission cross section ratio in the 235U fission neutron spectrum

International Nuclear Information System (INIS)

Azimi-Garakani, D.; Bagheri-Darbandi, M.

1983-06-01

Fission cross section ratio of 235 U to 238 U has been measured in the fast neutron field generated by the 235 U fission plate installed on the thermal column of the Tehran Research Reactor (TRR) with a Makrofol solid state nuclear track detector. The experiments were carried out with a set of total six enriched 235 U and depleted 238 U deposits with different masses and Makrofol films of 0.025mm and 0.060mm thicknesses. The chemically etched tracks were counted by an optical microscope. No significant differences were observed with the thin and the thick films. The results showed that the average fission cross section ratio is 3.83+-0.25. (author)

75 FR 773 - TSCA Section 5 Premanufacture and Significant New Use Notification Electronic Reporting...

Science.gov (United States)

2010-01-06

... Java 6 programming language, which can be downloaded free from http://www.java.com , if it is not... application programming interface to enable the submitter to interact with CDX to encrypt the submission. The...

The fission cross sections of 230Th, 232Th, 233U, 234U, 236U, 238U, 237Np, 239Pu and 242Pu relative 235U at 14.74 MeV neutron energy

International Nuclear Information System (INIS)

Meadows, J.W.

1986-12-01

The measurement of the fission cross section ratios of nine isotopes relative to 235 U at an average neutron energy of 14.74 MeV is described with particular attention to the determination of corrections and to sources of error. The results are compared to ENDF/B-V and to other measurements of the past decade. The ratio of the neutron induced fission cross section for these isotopes to the fission cross section for 235 U are: 230 Th - 0.290 +- 1.9%; 232 Th - 0.191 +- 1.9%; 233 U - 1.132 +- 0.7%; 234 U - 0.998 +- 1.0%; 236 U - 0.791 +- 1.1%; 238 U - 0.587 +- 1.1%; 237 Np - 1.060 +- 1.4%; 239 Pu - 1.152 +- 1.1%; 242 Pu - 0.967 +- 1.0%. 40 refs., 11 tabs., 9 figs

DENSITY-FUNCTIONAL STUDY OF U-Mo AND U-Zr ALLOYS

Energy Technology Data Exchange (ETDEWEB)

Landa, A; Soderlind, P; Turchi, P A

2010-11-01

Density-functional theory previously used to describe phase equilibria in U-Zr alloys [A. Landa, P. Soederlind, P.E.A. Turchi, J. Alloys Comp. 478 (2009) 103-110] is extended to investigate the ground-state properties of U-Mo solid solutions. We discuss how the heat of formation in both alloys correlates with the charge transfer between the alloy components, and how the specific behavior of the density of states in the vicinity of the Fermi level promotes the stabilization of the U{sub 2}Mo compound. Our calculations prove that, due to the existence of a single {gamma}-phase over the typical fuel operation temperatures, {gamma}-U-Mo alloys should indeed have much lower constituent redistribution than {gamma}-U-Zr alloys for which binodal decomposition causes a high degree of constituent redistribution.

Homeobox gene expression in Brachiopoda

DEFF Research Database (Denmark)

Altenburger, Andreas; Martinez, Pedro; Wanninger, Andreas

2011-01-01

(ectoderm) specification with co-opted functions in notochord formation in chordates and left/right determination in ambulacrarians and vertebrates. The caudal ortholog, TtrCdx, is first expressed in the ectoderm of the gastrulating embryo in the posterior region of the blastopore. Its expression stays......The molecular control that underlies brachiopod ontogeny is largely unknown. In order to contribute to this issue we analyzed the expression pattern of two homeobox containing genes, Not and Cdx, during development of the rhynchonelliform (i.e., articulate) brachiopod Terebratalia transversa...... completion of larval development, which is marked by a three-lobed body with larval setae. Expression starts at gastrulation in two areas lateral to the blastopore and subsequently extends over the animal pole of the gastrula. With elongation of the gastrula, expression at the animal pole narrows to a small...

U enrichment and Th/U fractionation in Archean boninites: Implications for paleo-ocean oxygenation and U cycling at juvenile subduction zones

Science.gov (United States)

Manikyamba, C.; Said, Nuru; Santosh, M.; Saha, Abhishek; Ganguly, Sohini; Subramanyam, K. S. V.

2018-05-01

Phanerozoic boninites record enrichments of U over Th, giving Th/U: 0.5-1.6, relative to intraoceanic island arc tholeiites (IAT) where Th/U averages 2.6. Uranium enrichment is attributed to incorporation of shallow, oxidized fluids, U-rich but Th-poor, from the slab into the melt column of boninites which form in near-trench to forearc settings of suprasubduction zone ophiolites. Well preserved Archean komatiite-tholeiite, plume-derived, oceanic volcanic sequences have primary magmatic Th/U ratios of 4.4-3.6, and Archean convergent margin IAT volcanic sequences, having REE and HFSE compositions similar to Phanerozoic IAT equivalents, preserve primary Th/U of 4-3.6. The best preserved Archean boninites of the 3.0 Ga Olondo and 2.7 Ga Gadwal greenstone belts, hosted in convergent margin ophiolite sequences, also show relative enrichments of U over Th, with low average Th/U ∼3 relative to coeval IAT, and Phanerozoic counterparts which are devoid of crustal contamination and therefore erupted in an intraoceanic setting, with minimal contemporaneous submarine hydrothermal alteration. Later enrichment of U is unlikely as Th-U-Nb-LREE patterns are coherent in these boninites whereas secondary effects induce dispersion of Th/U ratios. The variation in Th/U ratios from Archean to Phanerozoic boninites of greenstone belts to ophiolitic sequences reflect on genesis of boninitic lavas at different tectono-thermal regimes. Consequently, if the explanation for U enrichment in Phanerozoic boninites also applies to Archean examples, the implication is that U was soluble in oxygenated Archean marine water up to 600 Ma before the proposed great oxygenation event (GOE) at ∼2.4 Ga. This interpretation is consistent with large Ce anomalies in some hydrothermally altered Archean volcanic sequences aged 3.0-2.7 Ga.

Thinking about U : Theorizing and testing U - and inverted U-shaped relationships in strategy research

NARCIS (Netherlands)

Haans, Richard; Pieters, Constant; He, Zilin

U- and inverted U-shaped relationships are increasingly explored in strategy research, with 11 percent of all articles published in Strategic Management Journal (SMJ) in 2008–2012 investigating such quadratic relationships. Moreover, a movement towards introducing moderation to quadratic

VIS-NIR Lightweight Spectrometer for the Sun and the Moon, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — EPIR Inc. and Brimrose Technology Corporation propose a miniaturized spectrometer covering the 0.35 to 2.3um wavelength range by integrating a Hg1-xCdxTe (MCT) -...

Axially symmetric U-O-Ln- and U-O-U-containing molecules from the control of uranyl reduction with simple f-block halides

International Nuclear Information System (INIS)

Arnold, Polly L.; Cowie, Bradley E.; Suvova, Marketa; Zegke, Markus; Love, Jason B.; Magnani, Nicola; Colineau, Eric; Griveau, Jean-Christophe; Caciuffo, Roberto

2017-01-01

The reduction of U"V"I uranyl halides or amides with simple Ln"I"I or U"I"I"I salts forms highly symmetric, linear, oxo-bridged trinuclear U"V/Ln"I"I"I/U"V, Ln"I"I"I/U"I"V/Ln"I"I"I, and U"I"V/U"I"V/U"I"V complexes or linear Ln"I"I"I/U"V polymers depending on the stoichiometry and solvent. The reactions can be tuned to give the products of one- or two-electron uranyl reduction. The reactivity and magnetism of these compounds are discussed in the context of using a series of strongly oxo-coupled homo- and heterometallic poly(f-block) chains to better understand fundamental electronic structure in the f-block. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

Axially symmetric U-O-Ln- and U-O-U-containing molecules from the control of uranyl reduction with simple f-block halides

Energy Technology Data Exchange (ETDEWEB)

Arnold, Polly L.; Cowie, Bradley E.; Suvova, Marketa; Zegke, Markus; Love, Jason B. [EaStCHEM School of Chemistry, University of Edinburgh (United Kingdom); Magnani, Nicola; Colineau, Eric; Griveau, Jean-Christophe; Caciuffo, Roberto [European Commission, Directorate for Nuclear Safety and Security, Joint Research Centre, Karlsruhe (Germany)

2017-08-28

The reduction of U{sup VI} uranyl halides or amides with simple Ln{sup II} or U{sup III} salts forms highly symmetric, linear, oxo-bridged trinuclear U{sup V}/Ln{sup III}/U{sup V}, Ln{sup III}/U{sup IV}/Ln{sup III}, and U{sup IV}/U{sup IV}/U{sup IV} complexes or linear Ln{sup III}/U{sup V} polymers depending on the stoichiometry and solvent. The reactions can be tuned to give the products of one- or two-electron uranyl reduction. The reactivity and magnetism of these compounds are discussed in the context of using a series of strongly oxo-coupled homo- and heterometallic poly(f-block) chains to better understand fundamental electronic structure in the f-block. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

Moral u Hrvatskoj u sociologijskoj perspektivi

OpenAIRE

ČRPIĆ, Gordan; VALKOVIĆ, Marijan

2000-01-01

U radu se obrađuje stanje morala u Republici Hrvatskoj na temelju empirijskih socioreligijskih istraživanja provedenih na općoj populaciji građana koncem 1997. i početkom 1998. godine na uzorku od 1245 ispitanika, te na populaciji studenata hrvatskih sveučilišta 1999. godine na uzorku od 692 ispitanika. Rezultati su prikazani kroz sedam poglavlja rada i pokazuju da su mladi općenito permisivniji s obzirom na sve promatrane dimenzije morala. Religioznost se pokazala kao jasan kriterij zauziman...

77 FR 31355 - Environmental Impacts Statements; Notice of Availability

Science.gov (United States)

2012-05-25

...: https://cdx.epa.gov . EIS No. 20120157, Final EIS, FTA, GA, Tier 1--Atlanta Beltline City of Atlanta..., Review Period Ends: 06/ 25/2012, Contact: Brian Smart 404-865-5600. EIS No. 20120158, Draft EIS, USACE...

Limitations on the precision of 238U/235U measurements and implications for environmental monitoring

International Nuclear Information System (INIS)

Russ III, G.P.

1997-01-01

The ability to determine the isotopic composition of uranium in environmental samples is an important component of the International Atomic Energy Agency's (IAEA) safeguards program, and variations in the isotopic ratio 238 U/ 235 U provide the most direct evidence of isotopic enrichment activities. The interpretation of observed variations in 238 U/ 235 U depends on the ability to distinguish enrichment from instrumental biases and any variations occurring in the environment but not related to enrichment activities. Instrumental biases that have historically limited the accuracy of 238 U/ 235 U determinations can be eliminated by the use of the 233 U/ 236 U double-spike technique. With this technique, it is possible to determine the 238 U/ 235 U in samples to an accuracy equal to the precision of the measurement, ca. 0.1% for a few 10's of nanograms of uranium. Given an accurate determination of 238 U/ 235 U, positive identification of enrichment activities depends on the observed value being outside the range of 238 U/ 235 U's expected as a result of natural or environmental variations. Analyses of a suite of soil samples showed no variation beyond 0.2% in 238 U/ 235 U

U Shrinivasa

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. U Shrinivasa. Articles written in Resonance – Journal of Science Education. Volume 17 Issue 4 April 2012 pp 365-377 General Article. The Evolution of Diesel Engines · U Shrinivasa · More Details Fulltext PDF ...

Annual report, October 1, 1979-September 30, 1980

International Nuclear Information System (INIS)

1981-05-01

This annual report covers research progress on each of the following areas: (1) PLT device, (2) PDX, (3) spheromak, (4) smaller devices, (5) theory, (6) TFTR, (7) applied physics, (8) TFTR blanket module experiments, (9) advanced toroidal facility, (10) advanced projects design and analysis, (11) engineering, and (12) fabrication, operations and maintenance

International Atomic Energy Agency Technical Committee Meeting, Innovative approaches to fusion energy, Pleasanton, CA, October 20-23, 1997

International Nuclear Information System (INIS)

Perkins, L. J.

1997-01-01

The Purpose of this Meeting is to provide a forum for discussion of approaches to fusion other than conventional tokamaks and stellarators, such as: (1) quasi-steady-state systems (mirrors, RFP's, spheromaks, FRC'S, spherical tori,...); (2) short-pulsed systems (liners, Z-pinch variants, plasma foci, novel ICF, ...); and (3) fusion technology innovations

Annual report, October 1, 1979-September 30, 1980

Energy Technology Data Exchange (ETDEWEB)

1981-05-01

This annual report covers research progress on each of the following areas: (1) PLT device, (2) PDX, (3) spheromak, (4) smaller devices, (5) theory, (6) TFTR, (7) applied physics, (8) TFTR blanket module experiments, (9) advanced toroidal facility, (10) advanced projects design and analysis, (11) engineering, and (12) fabrication, operations and maintenance. (MOW)

234U/238U activity ratio in groundwater - an indicator of past hydrogeological processes

International Nuclear Information System (INIS)

Rasilainen, K.; Suksi, J.; Marcos, N.; Nordman, H.

2005-01-01

In this report we describe the long-term behaviour of the uranium isotopes, U-234 and U-238 in groundwater systems. U is a redox sensitive element what for its behaviour is largely controlled by changes in the environmental conditions. A striking feature in U isotope geochemistry is seemingly different behaviour of U-238 and U-234. U isotopes fractionate at the rock-groundwater interface depending on chemical and radiological factors. Changes of the redox conditions in groundwater may thus affect the behaviour of U and its isotopes resulting in variable U concentration and U-234/U-238 activity ratios (AR). We examined the formation of ARs in different groundwater types from a geochemical and a physical/radiological point of view. It was envisaged that AR in groundwater is the consequence of radiological, chemical and hydrological processes. Groundwater condition (redox, flow, etc.) play a very important role in controlling the mass flow of U isotopes. Quantitative α-recoil modelling showed that α-recoil induced flux can be considered insignificant in cases of high-flow. This was an important finding because the exclusion of direct a-recoil means that it is groundwater chemistry and its variations which controls the U-234 mass flow and the formation of AR. Therefore, AR values could be used more confidently to indicate past redox changes and possibly flow paths. (orig.)

Higgs phenomenology in the minimal S U (3 )L×U (1 )X model

Science.gov (United States)

Okada, Hiroshi; Okada, Nobuchika; Orikasa, Yuta; Yagyu, Kei

2016-07-01

We investigate the phenomenology of a model based on the S U (3 )c×S U (3 )L×U (1 )X gauge theory, the so-called 331 model. In particular, we focus on the Higgs sector of the model which is composed of three S U (3 )L triplet Higgs fields and is the minimal form for realizing a phenomenologically acceptable scenario. After the spontaneous symmetry breaking S U (3 )L×U (1 )X→S U (2 )L×U (1 )Y , our Higgs sector effectively becomes that with two S U (2 )L doublet scalar fields, in which the first- and the second-generation quarks couple to a different Higgs doublet from that which couples to the third-generation quarks. This structure causes the flavor-changing neutral current mediated by Higgs bosons at the tree level. By taking an alignment limit of the mass matrix for the C P -even Higgs bosons, which is naturally realized in the case with the breaking scale of S U (3 )L×U (1 )X much larger than that of S U (2 )L×U (1 )Y, we can avoid current constraints from flavor experiments such as the B0-B¯ 0 mixing even for the Higgs bosons masses that are O (100 ) GeV . In this allowed parameter space, we clarify that a characteristic deviation in quark Yukawa couplings of the Standard Model-like Higgs boson is predicted, which has a different pattern from that seen in two Higgs doublet models with a softly broken Z2 symmetry. We also find that the flavor-violating decay modes of the extra Higgs boson, e.g., H /A →t c and H±→t s , can be dominant, and they yield the important signature to distinguish our model from the two Higgs doublet models.

ARIES-ST STUDIES REPORT FOR THE PERIOD JANUARY 1, 1998 THROUGH DECEMBER 31, 1998

International Nuclear Information System (INIS)

V.S. CHAN; L.L. LAO; Y.R. LIN-LIU; R.L. MILLER; T.W. PETRIE; P.A. POLITZER; R. PRATER; M.J. SCHAFFER; G.M. STAEBLER; R.D. STAMBAUGH; A.D. TURNBULL; W.P.WEST

1999-01-01

During 1998, the General Atomics (GA) ARIES-Spherical Torus (ST) team examined several critical issues related to the physics performance of the ARIES-ST design, and a number of suggestions were made concerning possible improvements in performance. These included specification of a reference plasma equilibrium, optimization about the reference equilibrium to achieve higher beta limits, examination of three possible schemes for plasma initiation, development of a detailed scenario for ramp-up of the plasma current and pressure to its full, final operating values, an assessment of the requirement for electron confinement, and several suggestions for divertor heat flux reduction. The reference equilibrium was generated using the TOQ code, with the specification of a 100%, self-consistent bootstrap current. The equilibrium has β = 51%, 10% below the stability limit (a margin specified by the ARIES-ST study). In addition, a series of intermediate equilibria were defined, corresponding to the ramp-up scenario discussed. A study of the influence of shaping on ARIES-ST performance indicates that significant improvement in both kink and ballooning stability can be obtained by modest changes in the squareness of the plasma. In test equilibria the ballooning beta limit is increased from 58% to 67%. Also the maximum allowable plasma-wall separation for kink stability can be increased by 30%. Three schemes were examined for noninductive plasma initiation. These are helicity injection (HICD), electron cyclotron heating (ECH)-assisted startup, and inductive startup using only the external equilibrium coils. HICD startup experiments have been done on the HIT and CDX devices. ECH-assisted startup has been demonstrated on CDX-U and DIII-D. External coil initiation is based on calculations for a proposed DIII-D experiment. In all cases, plasma initiation and preparation of an approximately 0.3 MA plasma for ARIES-ST appears entirely feasible

Resonance Region Covariance Analysis Method and New Covariance Data for Th-232, U-233, U-235, U-238, and Pu-239

International Nuclear Information System (INIS)

Leal, Luiz C.; Arbanas, Goran; Derrien, Herve; Wiarda, Dorothea

2008-01-01

Resonance-parameter covariance matrix (RPCM) evaluations in the resolved resonance region were done for 232Th, 233U, 235U, 238U, and 239Pu using the computer code SAMMY. The retroactive approach of the code SAMMY was used to generate the RPCMs for 233U, 235U. RPCMs for 232Th, 238U and 239Pu were generated together with the resonance parameter evaluations. The RPCMs were then converted in the ENDF format using the FILE32 representation. Alternatively, for computer storage reasons, the FILE32 was converted in the FILE33 cross section covariance matrix (CSCM). Both representations were processed using the computer code PUFF-IV. This paper describes the procedures used to generate the RPCM with SAMMY.

Uranium 234U and 238U isotopes in the southern Baltic environment

International Nuclear Information System (INIS)

Borylo, A.; Skwarzec, B.

2002-01-01

The concentration and distribution of uranium in water and sediment of selected basins of the southern Baltic Sea have been analysed. It was observed that the concentration of uranium in sediments increases with core depth. This is probably connected to diffusion processes from sediments to water through interstitial water where uranium concentration is much higher than in bottom water. The measurements of 234 U/ 238 U activity ratios indicate that sedimentation of terrigenic material and transport through Vistula river are the major sources of uranium in sediments of the southern Baltic Sea. Estimation of the 234 U/ 238 U ratios in reduction areas of the Baltic Deep and the Bornholm Deep suggest that the processes of reduction of U(VI) to U(IV) and of removal of authogenic uranium from seawater to sediments do not play major roles in the Gdansk Deep. (author)

Seoska prehrana u Baranji

OpenAIRE

Somek-Machala, Božica

1993-01-01

Način prehrane seoskog stanovništva u uskoj je vezi s krajem, društvenim i povijesnim prilikama u kojima živi, te duhovnom kulturnom vezom uz tradiciju, običaje i religiju, koji diktiraju izbor hrane, način pripreme i broj obroka u svakodnevnoj prehrani i u onoj koja prati određene rituale.

Kemija u nastavi: Etimološki pristup učenju kemije

OpenAIRE

Raos, Nenad; Raos (ur.), Nenad

2018-01-01

Etimološki pristup učenju kemije je u tome da ne objasnimo samo što ime ili termin znači nego i da ukažemo na njegovo izvorno značenje te objasnimo kako je našao svoj put do kemije. U članku se razmatra povijest anorganske kemije kroz povijest imenovanja kemijskih elemenata. Povijest pak organske kemije otkriva, upravo kroz imena spojeva, da se temeljila prije svega na izolaciji čistih tvari iz prirodnih materijala. Etimološki pristup učenju kemije olakšava usvajanje kemijske nomenklature i t...

U.S. Level III and IV Ecoregions (U.S. EPA)

Data.gov (United States)

U.S. Environmental Protection Agency — This map service displays Level III and Level IV Ecoregions of the United States and was created from ecoregion data obtained from the U.S. Environmental Protection...

Thermodynamic calculation of phase equilibria of the U-Ga and U-W systems

International Nuclear Information System (INIS)

Wang, J.; Liu, X.J.; Wang, C.P.

2008-01-01

The thermodynamic assessments of the U-Ga and U-W systems have been carried out by using the CALPHAD (calculation of phase diagrams) method using experimental data including thermodynamic properties and phase equilibria. Gibbs free energies of the solution phases were described by the subregular solution models with the Redlich-Kister equation, and those of the intermetallic compounds were described by the sublattice models. A consistent set of thermodynamic parameters has been derived for the Gibbs free energy of each phase in the U-Ga and U-W binary systems, respectively. The calculated phase diagrams and thermodynamic properties in the U-Ga and U-W systems are in good agreement with experimental data

Algebraic formulas for some nontrivial U/sub n/ 6j symbols and U/sub m/n contains U/sub m/ x U/sub n/ 3jm symbols

International Nuclear Information System (INIS)

Haase, R.W.; Butler, P.H.

1985-01-01

We give tables of algebraic formulas for some nontrivial 6j symbols and 3jm symbols of the unitary groups. The tables demonstrate that the building-up method can be used successfully to obtain the rank dependence of unitary group j and jm symbols. To emphasize the rank-dependent nature of this calculation, we have employed the composite Young tableaux notation (or back-to-back notation) to label the unitary group irreps. In using this notation, the transpose conjugate symmetry of the corresponding composite Young diagram leads to a new symmetry of the unitary group 6j and 3jm symbols. The transposition of the groups U/sub m/ and U/sub n/ gives rise to a further symmetry of the 3jm symbols of U/sub m/n contains U/sub m/ x U/sub n/

Path integral for coherent states of the dynamical U2 group and U2/1 supergroup

International Nuclear Information System (INIS)

Kochetov, E.A.

1992-01-01

A part-integral formulation in the representation of coherent states for the unitary U 2 group and U 2/1 supergroup is introduced. U 2 and U 2/1 path integrals are shown to be defined on the coset spaces U 2 /U 1 xU 1 and U 2/1 /U 1/1 xU 1 , respectively. These coset appears as curved classical phase spaces. Partition functions are expressed as path integrals over these spaces. In the case when U 2 and U 2/1 are the dynamical groups, the corresponding path integrals are evaluated with the help of linear fractional transformations that appear as the group (supergroup) action in the coset space (superspace). Possible applications for quantum models are discussed. 9 refs

Initial Results of the SSPX Transient Internal Probe System for Measuring Toroidal Field Profiles

Science.gov (United States)

Holcomb, C. T.; Jarboe, T. R.; Mattick, A. T.; Hill, D. N.; McLean, H. S.; Wood, R. D.; Cellamare, V.

2000-10-01

Lawrence Livermore National Laboratory, Livermore, CA 94550, USA. The Sustained Spheromak Physics Experiment (SSPX) is using a field profile diagnostic called the Transient Internal Probe (TIP). TIP consists of a verdet-glass bullet that is used to measure the magnetic field by Faraday rotation. This probe is shot through the spheromak by a light gas gun at speeds near 2 km/s. An argon laser is aligned along the path of the probe. The light passes through the probe and is retro-reflected to an ellipsometer that measures the change in polarization angle. The measurement is spatially resolved down to the probes’ 1 cm length to within 15 Gauss. Initial testing results are given. This and future data will be used to determine the field profile for equilibrium reconstruction. TIP can also be used in conjunction with wall probes to map out toroidal mode amplitudes and phases internally. This work was performed under the auspices of US DOE by the University of California Lawrence Livermore National Laboratory under Contract No. W-7405-ENG-48.

Current drive by neutral beams, rotating magnetic fields and helicity injection in compact toroids

International Nuclear Information System (INIS)

Farengo, R.

2002-01-01

A Monte-Carlo code is used to study neutral beam current drive in Spheromaks. The exact particle trajectories are followed in the self-consistent equilibria calculated including the beam current. Reducing Z(eff) does not increase the current drive efficiency because the reduction of the stopping cross section is compensated by an increase in the electron canceling current. Significant changes in the safety factor profile can be produced with relatively low beam currents. Minimum dissipation states of a flux core spheromak sustained by helicity injection are presented. Helicity balance is used as a constraint and the resistivity is considered to be non-uniform. Two types of relaxed states are found; one has a central core of open flux surrounded by a toroidal region of closed flux surfaces and the other has the open flux wrapped around the closed flux surfaces. Non-uniform resistivity effects can be very important due to the changes they produce in the safety factor profile. A hybrid, fluid electrons particle ions, code is employed to study ion dynamics in FRCs sustained by rotating magnetic fields. (author)

Numerical Study of the Formation, Ion Spin-up and Nonlinear Stability Properties of Field-reversed Configurations

International Nuclear Information System (INIS)

Belova, E.V.; Davidson, R.C.; Ji, H.; Yamada, M.; Cothran, C.D.; Brown, M.R.; Schaffer, M.J.

2004-01-01

Results of three-dimensional numerical simulations of field-reversed configurations (FRCs) are presented. Emphasis of this work is on the nonlinear evolution of magnetohydrodynamic (MHD) instabilities in kinetic FRCs and the new FRC formation method by the counter-helicity spheromak merging. Kinetic simulations show nonlinear saturation of the n = 1 tilt mode, where n is the toroidal mode number. The n = 2 and n = 3 rotational modes are observed to grow during the nonlinear phase of the tilt instability due to the ion spin-up in the toroidal direction. The ion toroidal spin-up is shown to be related to the resistive decay of the internal flux, and the resulting loss of particle confinement. Three-dimensional MHD simulations of counter-helicity spheromak merging and FRC formation show good agreement with results from the SSX-FRC experiment. Simulations show formation of an FRC in about 30 Alfven times for typical experimental parameters. The growth rate of the n = 1 tilt mode is shown to be significantly reduced compared to the MHD growth rate due to the large plasma viscosity and field-line-tying effects

U.S.-South Korea Relations

Science.gov (United States)

2012-05-15

After Realignment Plan Is Implemented................................................... 22 Tables Table 1. Annual U.S.-South Korea Merchandise ...In addition to their formal dinner, Obama and Lee had a private dinner at a local Korean restaurant and made a joint visit to a General Motors...U.S. trade. Table 1. Annual U.S.-South Korea Merchandise Trade, Selected Years (Billions of Nominal U.S. Dollars) Year U.S. Exports U.S. Imports

The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180)

DEFF Research Database (Denmark)

Behrendt, Niels

2004-01-01

The breakdown of the barriers formed by extracellular matrix proteins is a pre-requisite for all processes of tissue remodeling. Matrix degradation reactions take part in specific physiological events in the healthy organism but also represent a crucial step in cancer invasion. These degradation...... on the surface of various cell types that serves to bind the urokinase plasminogen activator and localize the activation reactions in the proteolytic cascade system of plasminogen activation. uPARAP is an integral membrane protein with a pronounced role in the internalization of collagen for intracellular...... degradation. Both receptors have additional functions that are currently being unraveled. The present discussion of uPAR and uPARAP is centered on their protein structure and molecular and cellular function....

RMP Guidance for Warehouses - Chapter 9: Risk Management Plan

Science.gov (United States)

Submit one RMP, including offsite consequence analysis, for all of your covered processes using the web-based RMP*eSubmit. Your RMP is then stored on EPA's Central Data Exchange (CDX) where you can access it and make changes or corrections.

RMP Guidance for Chemical Distributors - Chapter 9: Risk Management Plan

Science.gov (United States)

You must submit one RMP for all of covered processes, using free software RMP*eSubmit on EPA's Central Data Exchange (CDX), and fully update and resubmit at least every five years. You may claim confidential business information and trade secrets.

235U and 238U (n,xn gamma) cross-sections

International Nuclear Information System (INIS)

Bacquias, A.; Dessagne, Ph.; Kerveno, M.; Rudolf, G.; Thiry, J.C.; Borcea, C.; Negret, A.L.; Drohe, J.C.; Nankov, N.; Nyman, M.; Plompen, A.; Rouki, C.; Stanoiu, M.

2014-01-01

The (n,n') and (n,2n) are important processes in the energy domain of fission neutrons, but the cross-sections suffer from large uncertainties, not compatible with the objectives fixed for future and advanced nuclear reactors. This paper presents our experimental effort to improve 235 U and 238 U (n,xnγ) cross-section data. The experiments were performed at the GELINA facility (Belgium), which provides a pulsed (800 Hz) neutron beam covering a wide energy spectrum (from a few eV to about 20 MeV). The GRAPhEME set-up is designed for prompt gamma spectroscopy and time-of-flight measurement. The analysis methods are presented. Already published results on 235 U are shown, as well as results on 238 U. The interpretation and discussion rely on the comparison with TALYS and EMPIRE predictions. (authors)

Antibody-based PET of uPA/uPAR signaling with broad applicability for cancer imaging

DEFF Research Database (Denmark)

Yang, Dongzhi; Severin, Gregory; Dougherty, Casey A.

2016-01-01

Mounting evidence suggests that the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a central role in tumor progression. The goal of this study was to develop an 89Zr-labeled, antibody-based positron emission tomography (PET) tracer for quantitative imaging of the uPA/uPAR system....... An anti-uPA monoclonal antibody (ATN-291) was conjugated with a deferoxamine (Df) derivative and subsequently labeled with 89Zr. Flow cytometry, microscopy studies, and competitive binding assays were conducted to validate the binding specificity of Df-ATN-291 against uPA. PET imaging with 89Zr-Df-ATN-291...... was carried out in different tumors with distinct expression levels of uPA. Biodistribution, histology examination, and Western blotting were performed to correlate tumor uptake with uPA or uPAR expression. ATN-291 retained uPA binding affinity and specificity after Df conjugation. 89Zr-labeling of ATN-291...

Magnetohydrodynamic Particle Acceleration Processes: SSX Experiments, Theory, and Astrophysical Applications

International Nuclear Information System (INIS)

Brown, Michael R.

2006-01-01

The purpose of the project was to provide theoretical and modeling support to the Swarthmore Spheromak Experiment (SSX). Accordingly, the theoretical effort was tightly integrated into the SSX experimental effort. During the grant period, Michael Brown and his experimental collaborators at Swarthmore, with assistance from W. Matthaeus as appropriate, made substantial progress in understanding the physics SSX plasmas

Physics issues of a proposed program, SPIRIT

International Nuclear Information System (INIS)

Ji, Hantao; Yamada, Masaaki

2000-01-01

Physics issues of the proposed program, SPIRIT (Self-organized Plasma with Induction, Reconnection, and Induction Techniques) are discussed. The main purpose of this program is to explore the physics of global stability and sustainment of compact toroids, including FRC (field reversed configuration) as well as low-aspect-ratio RFP (reversed field pinch), spheromak and spherical torus. (author)

U.S. uranium supply outlook

International Nuclear Information System (INIS)

Hogerton, J.F.

1977-01-01

The subject is analysed in the light of figures and forecasts contained in the following diagrams: forecasts of U.S. uranium production, 1977 to 1990; indicated relationship between annual U.S. uranium supply and demand, 1977 to 1986; presently indicated cumulative U.S. uranium supply/demand balance, 1977 to 1990; indicated cumulative U.S. supply/demand balance (shortage or surpluses) 1976 to 1990; presently indicated balance between outstanding U.S. utility procurement needs and uncommitted domestic supply capability 1977 to 1986; projected U.S. uranium requirements in relation to existing supply base and presently indicated additional domestic resource potential, 1977 to 2000. (U.K.)

Modern applied U-statistics

CERN Document Server

Kowalski, Jeanne

2008-01-01

A timely and applied approach to the newly discovered methods and applications of U-statisticsBuilt on years of collaborative research and academic experience, Modern Applied U-Statistics successfully presents a thorough introduction to the theory of U-statistics using in-depth examples and applications that address contemporary areas of study including biomedical and psychosocial research. Utilizing a "learn by example" approach, this book provides an accessible, yet in-depth, treatment of U-statistics, as well as addresses key concepts in asymptotic theory by integrating translational and cross-disciplinary research.The authors begin with an introduction of the essential and theoretical foundations of U-statistics such as the notion of convergence in probability and distribution, basic convergence results, stochastic Os, inference theory, generalized estimating equations, as well as the definition and asymptotic properties of U-statistics. With an emphasis on nonparametric applications when and where applic...

The Effect of Early Diagenesis on the 238U/235U Ratio of Platform Carbonates.

Science.gov (United States)

Tissot, F.; Chen, C.; Go, B. M.; Naziemiec, M.; Healy, G.; Swart, P. K.; Dauphas, N.

2017-12-01

In the past 15 years, the so-called non-traditional stable isotopes systems (e.g., Mg, Fe, Mo, U) have emerged as powerful tracers of both high-T and low-T geochemical processes (e.g., [1]). Of particular interest for paleoredox studies is the ratio of "stable" isotopes of U (238U/235U), which has the potential to track the global extent of oceanic anoxia (e.g., [2, 3]). Indeed, in the modern ocean, U exists in two main oxidation states, soluble U6+ and insoluble U4+, and has a mean residence time of 400 kyr ([4]), much longer than the global ocean mixing time (1-2 kyr). As such the salinity-normalized ocean is homogeneous with regards to both U concentrations and isotopes (δ238USW = -0.392±0.005 ‰, [2]). The value of δ238USW at any given time is therefore the balance between U input to the ocean, mainly from rivers, and U removal, mostly into biogenic carbonates, anoxic/euxinic sediments and suboxic/hypoxic sediments (e.g., [2, 5]). Because the 238U/235U ratio of the past ocean cannot be measured directly, it has to be estimated from the measurement of the 238U/235U ratio of a sedimentary rock and assuming a constant fractionation factor. Carbonates appear as a promising record since they span most of Earth's history, and the δ238U values of modern primary carbonate precipitates and well-preserved fossil aragonitic coral up to 600 ka are indistinguishable from that of seawater (e.g., [2, 6, 7]). Yet, the effect of secondary processes on the δ238U values of non-coral carbonates, which represent the bulk of the rock record, has only been studied in a handful of shallow samples (down to 40cm, [6]) and remains poorly understood. To investigate the effect of early diagenesis on the 238U/235U ratio of carbonates on the 30kyr to 1Myr timescale, we measured δ13C, δ18O, and δ238U in samples from a 220m long drill core from the Bahamas carbonate platform. In order to separate lattice bound U from secondary U we developed a leaching protocol applicable to carbonate

Interdiffusion between U(Mo,Pt) or U(Mo,Zr) and Al or Al A356 alloy

International Nuclear Information System (INIS)

Komar Varela, C.; Mirandou, M.; Arico, S.; Balart, S.; Gribaudo, L.

2009-01-01

Solid state reactions in chemical diffusion couples U-7 wt.%Mo-0.9 wt.%Pt/Al at 580 deg. C and U-7 wt.%Mo-0.9 wt.%Pt/Al A356 alloy, U-7 wt.%Mo-1 wt.%Zr/Al and U-7 wt.%Mo-1 wt.%Zr/Al A356 alloy at 550 deg. C were characterized. Results were obtained from optical and scanning electron microscopy, electron probe microanalysis and X-ray diffraction. The UAl 3, UAl 4 and Al 20 Mo 2 U phases were identified in the interaction layers of γU(Mo,Pt)/Al and γU(Mo,Zr)/Al diffusion couples. Al 43 Mo 4 U 6 ternary compound was also identified in γU(Mo,Zr)/Al due to the decomposition of γU(Mo,Zr) phase. The U(Al,Si) 3 and U 3 Si 5 phases were identified in the interaction layers of γU(Mo,Pt)/Al A356 and γU(Mo,Zr)/Al A356 diffusion couples. These phases are formed due to the migration of Si to the interaction layer. In the diffusion couple U(Mo,Zr)/Al A356, Zr 5 Al 3 phase was also identified in the interaction layer. The use of synchrotron radiation at Brazilian Synchrotron Light Laboratory (LNLS, CNPq, Campinas, Brazil) was necessary to achieve a complete crystallographic characterization.

Ekvivalences pamata kategorijas , tulkojot specializētos tekstus ar angļu-latviešu un latviešu-angļu tulkojumu piemēriem

OpenAIRE

Saveļjevs, Jurijs

2014-01-01

Maģistra darbs ar nosaukumu „Ekvivalences pamata kategorijas, tulkojot specializētos tekstus, ar angļu-latviešu un latviešu-angļu tulkojumu piemēriem” ir veltīts dabiskās un virzītās, kā arī formālās un dinamiskās ekvivalences jēdzienu pētījumam. Darba teorētiskajā daļā tiek iztirzāta leksiski-sintaktisko valodas elementu ekvivalences jēdziena izcelsme un attīstība, tā pašreizējais stāvoklis un dažādu pētnieku tā redzējums. tāpat tiek izvērtētas ekvivalences jēdziena pamata kategorijas – dabi...

γ-U phase in U-Pt system retained to low temperatures by means of rapid cooling

Energy Technology Data Exchange (ETDEWEB)

Kim-Ngan, N.-T.H., E-mail: tarnawsk@up.krakow.pl [Institute of Physics, Pedagogical University, Podchorazych 2, 30 084 Kraków (Poland); Paukov, M. [Faculty of Mathematics and Physics, Charles University, Ke Karlovu 5, 12116 Prague (Czech Republic); Tarasenko, R. [Faculty of Mathematics and Physics, Charles University, Ke Karlovu 5, 12116 Prague (Czech Republic); Institute of Physics, Faculty of Science, P.J. Šafárik University, Park Angelinum 9, 04154 Košice (Slovakia); Tkáč, V.; Minarik, P.; Drozdenko, D.; Havela, L. [Faculty of Mathematics and Physics, Charles University, Ke Karlovu 5, 12116 Prague (Czech Republic)

2016-10-15

Splat-cooling technique with a cooling rate better than 10{sup 6} K/s helps to increase the Pt solubility in the (cubic) γ-U phase and retain such γ-U phase in U-15 at.% Pt splat down to low temperatures. The splat-cooled U-Pt alloys are very stable in exposing to air. The γ-U phase (U-15 at.% Pt splat) is characterized by a negative temperature coefficient of the resistivity (dρ/dT < 0). The splats become superconducting below 1.1 K. - Highlights: • γ-U phase stabilization in U-15 at.% Pt splat-cooled alloys. • Splat-cooling helps to increase the Pt solubility in cubic γ-U phase. • All U-Pt alloys (0–15 at.% Pt) become superconducting below 1.1 K.

238U, 234U and 230Th in uranium miners' lungs

International Nuclear Information System (INIS)

Singh, M.P.; Wrenn, M.E.; Archer, V.E.; Saccomanno, G.

1981-01-01

Fourteen uranium miners' lungs from Colorado plateau were collected at autopsy and the concentrations of 238 U, 234 U and 230 Th were determined by radiochemical procedures utilizing solvent extraction - alpha spectrometric techniques. The uranium and thorium isotopes are in near equilibrium with average concentrations of 238 U, 234 U and 230 Th being 89.3, 95.2 and 91.1 pCi/kg respectively. The combined average radiation dose rate to lung from these three isotopes is about 24.2 mrad/year at death excluding the unmeasured contribution from the 226 Ra and daughters. The average concentration of 230 Th is about 65 times higher than the mean concentration of 230 Th in lungs of non-miners dying at comparable ages from the same region

222Rn content and 234U/238U activity ratio in groundwaters

International Nuclear Information System (INIS)

Olguin, M.T.; Segovia, N.; Ordonez, E.; Iturbe, J.L.; Bulbulian, S.; Carrillo, J.

1990-01-01

Geochemical radioanalytical studies of ground water were perfomed in the valleys of Villa de Reyes and San Luis Potosi, Mexico. The experiments were designed to measure radon and uranium content and 234 U/ 238 U activity ratio in ground water samples taken from wells in these sites and at the Nuclear Center of Salazar, Mexico. 222 Rn content varied depending on the sample source, reaching a maximum value of 235 pCi/l; uranium concentration results were less than 1 μg/l and 234 U/ 238 U activity ratios were close to equilibrium. (author) 9 refs.; 1 fig.; 1 tab

General RMP Guidance - Chapter 9: Risk Management Plan

Science.gov (United States)

You must submit one risk management plan (RMP) to EPA for all of your covered processes. The internet-based RMP*eSubmit allows you to submit your RMP in EPA's Central Data Exchange (CDX), where you can access and change/correct existing RMPs.

Hydration structures of U(III) and U(IV) ions from ab initio molecular dynamics simulations

International Nuclear Information System (INIS)

Leung, Kevin; Nenoff, Tina M.

2012-01-01

We apply DFT+U-based ab initio molecular dynamics simulations to study the hydration structures of U(III) and U(IV) ions, pertinent to redox reactions associated with uranium salts in aqueous media. U(III) is predicted to be coordinated to 8 water molecules, while U(IV) has a hydration number between 7 and 8. At least one of the innershell water molecules of the hydrated U(IV) complex becomes spontaneously deprotonated. As a result, the U(IV)–O pair correlation function exhibits a satellite peak at 2.15 Å associated with the shorter U(IV)–(OH − ) bond. This feature is not accounted for in analysis of extended x-ray absorption fine structure and x-ray adsorption near edge structure measurements, which yield higher estimates of U(IV) hydration numbers. This suggests that it may be useful to include the effect of possible hydrolysis in future interpretation of experiments, especially when the experimental pH is close to the reported hydrolysis equilibrium constant value.

Abreniešu identitāte atmiņu stāstos

OpenAIRE

Rātfeldere, Linda

2013-01-01

Izmantojot gan biogrāfiskās intervijas ar abreniešiem, gan muzejos un arhīvos iegūtos materiālus, bakalaura darba "Abreniešu identiāte atmiņu stāstos" mērķis ir caur atmiņu stāstiem pētīt abreniešu identitāti, tās trīs komponentus: vietu, valodu un savstarpējās attiecības. Šim nolūkam, pirmkārt, sniegts Abrenes vēsturiskais, sociālais un kultūras konteksts, plašāk aplūkojot tos aspektus, kas ir būtiski tieši identitātes izpētē. Otrkārt, analizētas abreniešu personiskās atmiņas par Abrenes kul...

Intake of 210Po, 234U and 238U radionuclides with beer in Poland

International Nuclear Information System (INIS)

Skwarzec, B.; Struminska, D.I.; Borylo, A.; Falandysz, J.

2004-01-01

238 U, 234 U and 210 Po activity concentrations were determined in beer in Poland by alpha-spectrometry with low-level activity silicon detectors. The results revealed that the mean concentrations of 238 U, 234 U and 210 Po in the analyzed beer samples were 4.63, 4.11 and 4.94 mBq x dm -3 , respectively, the highest in Tyskie (5.71 for 210 Po, 5.06 for 234 U and 6.11 for 238 U) and the lowest in Lech (2.49 for 210 Po). The effective radiation dose due to uranium and polonium ingestions by beer was calculated and were compared to the effective radiation dose from drinking water. (author)

Geochemical control on the reduction of U(VI) to mononuclear U(IV) species in lacustrine sediments

Science.gov (United States)

Stetten, L.; Mangeret, A.; Brest, J.; Seder-Colomina, M.; Le Pape, P.; Ikogou, M.; Zeyen, N.; Thouvenot, A.; Julien, A.; Alcalde, G.; Reyss, J. L.; Bombled, B.; Rabouille, C.; Olivi, L.; Proux, O.; Cazala, C.; Morin, G.

2018-02-01

Contaminated systems in which uranium (U) concentrations slightly exceed the geochemical background are of particular interest to identify natural processes governing U trapping and accumulation in Earth's surface environments. For this purpose, we examined the role of early diagenesis on the evolution of U speciation and mobility in sediments from an artificial lake located downstream from a former mining site. Sediment and pore water chemistry together with U and Fe solid state speciation were analyzed in sediment cores sampled down to 50 cm depth at four locations in the lake. These organic-rich sediments (∼12% organic C) exhibited U concentrations in the 40-80 mg kg-1 range. The sediment columns were anoxic 2-3 mm below the sediment-water interface and pore waters pH was circumneutral. Pore water chemistry profiles showed that organic carbon mineralization was associated with Fe and Mn reduction and was correlated with a decrease in dissolved U concentration with depth. Immobilization of U in the sediment was correlated with the reduction of U(VI) to U(IV) at depth, as shown by U LIII-edge XANES spectroscopic analysis. XANES and EXAFS spectroscopy at the Fe K-edge showed the reduction of structural Fe(III) to Fe(II) in phyllosilicate minerals with depth, coincident with U(VI) to U(IV) reduction. Thermodynamic modeling suggests that Fe(II) could act as a major reducing agent for U(VI) during early diagenesis of these sediments, leading to complete U reduction below ∼30 cm depth. Shell-by-shell and Cauchy-Wavelet analysis of U LIII-EXAFS spectra indicates that U(VI) and U(IV) are mainly present as mononuclear species bound to C, P or Si ligands. Chemical extractions confirmed that ∼60-80% of U was present as non-crystalline species, which emphasizes that such species should be considered when evaluating the fate of U in lacustrine environments and the efficiency of sediment remediation strategies.

Quantum algebra U{sub qp}(u{sub 2}) and application to the rotational collective dynamics of the nuclei; Algebre quantique U{sub qp}(u{sub 2}) et application a la dynamique collective de rotation dans les noyaux

Energy Technology Data Exchange (ETDEWEB)

Barbier, R

1995-09-22

This thesis concerns some aspects of new symmetries in Nuclear Physics. It comprises three parts. The first one is devoted to the study of the quantum algebra U{sub qp}(u{sub 2}). More precisely, we develop its Hopf algebraic structure and we study its co-product structure. The bases of the representation theory of U{sub qp}(u{sub 2}) are introduced. On one hand, we construct the finite-dimensional irreducible representations of U{sub qp}(u{sub 2}). On the other hand, we calculate the Clebsch-Gordan coefficients with the projection operator method. To complete our study, we construct some deformed boson mappings of the quantum algebras U{sub qp}(u{sub 2}), U{sub q{sup 2}}(su{sub 2}) and U{sub qp}(u{sub 1,1}). The second part deals with the construction of a new phenomenological model of the non rigid rotator. This model is based on the quantum algebra U{sub qp}(u{sub 2}). The rotational energy and the E2 reduced transition probabilities are obtained. They depend on the two deformation parameters q and p of the quantum algebra. We show how the use of the two-parameter deformation of the algebra U{sub qp}(u{sub 2}) leads to a generalization of the U{sub q}(su{sub 2})-rotator model. We also introduce a new model of the anharmonic oscillator on the basis of the quantum algebra U{sub qp}(u{sub 2}). We show that the system of the U{sub q}(su{sub 2})-rotator and of the anharmonic oscillator can be coupled with the use of the deformation parameters of U{sub qp}(u{sub 2}). A ro-vibration energy formula and expansion `a la` Dunham are obtained. The aim of the last part is to apply our non rigid rotator model to the rotational collective dynamics of the superdeformed nuclei of the A{approx}130 - 150 and A{approx}190 mass regions and deformed nuclei of the actinide and rare earth series. We adjust the free parameters of our model and compare our results with those from four other models of the non rigid rotator. A comparative analysis is given in terms of transition energies.

uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells.

Science.gov (United States)

Laurenzana, Anna; Chillà, Anastasia; Luciani, Cristina; Peppicelli, Silvia; Biagioni, Alessio; Bianchini, Francesca; Tenedini, Elena; Torre, Eugenio; Mocali, Alessandra; Calorini, Lido; Margheri, Francesca; Fibbi, Gabriella; Del Rosso, Mario

2017-09-15

In this manuscript, we show the involvement of the uPA/uPAR system in the regulation of aerobic glycolysis of melanoma cells. uPAR over-expression in human melanoma cells controls an invasive and glycolytic phenotype in normoxic conditions. uPAR down-regulation by siRNA or its uncoupling from integrins, and hence from integrin-linked tyrosine kinase receptors (IL-TKRs), by an antagonist peptide induced a striking inhibition of the PI3K/AKT/mTOR/HIF1α pathway, resulting into impairment of glucose uptake, decrease of several glycolytic enzymes and of PKM2, a checkpoint that controls metabolism of cancer cells. Further, binding of uPA to uPAR regulates expression of molecules that govern cell invasion, including extracellular matrix metallo-proteinases inducer (EMPPRIN) and enolase, a glycolytyc enzyme that also serves as a plasminogen receptor, thus providing a common denominator between tumor metabolism and phenotypic invasive features. Such effects depend on the α5β1-integrin-mediated uPAR connection with EGFR in melanoma cells with engagement of the PI3K-mTOR-HIFα pathway. HIF-1α trans-activates genes whose products mediate tumor invasion and glycolysis, thus providing the common denominator between melanoma metabolism and its invasive features. These findings unveil a unrecognized interaction between the invasion-related uPAR and IL-TKRs in the control of glycolysis and disclose a new pharmacological target (i.e., uPAR/IL-TKRs axis) for the therapy of melanoma. © 2017 UICC.

Bruksizam u djece

OpenAIRE

Crnić, Kristina

2017-01-01

Bruksizam se definira kao parafunkcijsko škripanje ili stiskanje zubima. Etiologija je nejasna, ali se danas smatra da postoji više uzročnih faktora. Među primarnim faktorima smatra se psihološki stres djeteta. Postoji manjak informacija o bruksizmu u djece zbog komplikacija provođenja istraživanja jer su ispitanici maloljetnici. Razne su metode koje se koriste u dijagnozi bruksizma. Uključuju stručno konstruirane upitnike i intervjue namijenjene i djeci i roditeljima te klinički pregled ...

A contribution to the kinetic study of the metatectic reaction U+U{sub 3}Si{sub 2}{yields}U{sub 3}Si; Contribucion al Estudio cinetico de la Reaccion Metatectica U+U{sub 3}Si{sub 2} U{sub 3}Si

Energy Technology Data Exchange (ETDEWEB)

Arroyo Ruiperez, J; Esteban Hernandez, J A

1962-07-01

An experimental study has been made to decide upon the advantages and drawbacks of the different methods and reagents employed in the metallography of U-Si alloys. It has been observed that all samples thermally treated to form the epsilon-phase undergo from the beginning a coalescence of the U{sub 3}Si{sub 2} particles, which makes practically useless any fine state of dispersion that might be present originally, as recommended by some authors. The coalescence of the U{sub 3}Si{sub 2} particle decreases the surface available for reaction and consequently the reaction rate. (Author) 7 refs.

Periodic light variations of young stars U X Orion and S U Auriga

International Nuclear Information System (INIS)

Minikulov, N.Kh.; Abdulloev, S.Kh.

2007-01-01

The light curves of young variable stars U X Orion and S U Auriga are created from archive data of Institute of Astrophysics of the Academy of Sciences of the Republic of Tajikistan and other sources. It is established that periodic light variations of young stars U X Orion and S U Auriga occurs to duration of 36.4 and 29.8 years, accordingly. It is supposed that such periodic light variations are connected with existence a planetary system around these stars

Pusaudžu trauksmes, pašcieņas un viņu māšu audzināšanas stilu saistība.

OpenAIRE

Valere, Linda

2007-01-01

Bakalaura darba tēma ir „Pusaudžu trauksmes, pašcieņas un viņu māšu audzināšanas stilu saistība”. Pusaudžu trauksme ir ļoti aktuāla problēma. Trauksmes traucējumu izplatība pusaudžiem svārstās no 12% līdz 17,3 % (Vasey & Ollendick, 2000 kā minēts Fraire, 2006), un tie rada lielu risku atkārtotiem trauksmes traucējumiem jau pieaugušā vecumā (Pine, Cohen, Gurley, Brook & Ma, 1998). Pētījuma mērķis ir noskaidrot, vai pastāv saistība starp pusaudžu trauksmi, pašcieņu un viņu māšu audzināšanas sti...

238U, 234U and 230Th in uranium miners' lungs

International Nuclear Information System (INIS)

Singh, N.P.; Wrenn, M.E.; Bennett, D.B.; Archer, V.; Saccomanno, G.

1982-01-01

Fourteen uranium miners' lungs from the Colorado Plateau were collected at autopsy and the concentrations of 238 U, 234 U and 230 Th were determined by radiochemical procedures utilizing solvent extraction and alpha spectrometric techniques. The uranium and thorium isotopes are in near equilibrium with average concentrations of 238 U, 234 U and 230 Th being 89.3, 95.2, and 91.1 pCi/kg respectively. The combined average radiation dose rate to lung from these three isotopes is about 24.1 mrad/year at death excluding the unmeasured contribution from the 226 Ra and daughters. The average concentration of 230 Th is about 65 times higher than the mean concentration of 230 Th in lungs of non-miners from the same region dying at comparable ages

Nu2U

DEFF Research Database (Denmark)

Sørensen, Hans Eibe; Williamson, Trevor

Abstract In September 2014, nine months after launching a major growth opportunity, Jenny Dunne, managing director of Nu2U, called for an extraordinary status meeting with her COO and CMO. A fast-growing online retailer of refurbished household appliances, Nu2U planned to acquire market share...... by improving internal logistics and delivery services, aided by a new, fully integrated software system. The company's gross profit had been increasing steadily, but recent accounts revealed a fall in net profit margins. It became apparent that implementation of the business plan for the project...... was problematic because of loose governance and poor communication across Nu2U's different specialist functions during planning and implementation. The Nu2U case illustrates how executives' cognition and span of control/overview may be hampered in fast-growing firms and how this ...

Uranium ((234)U, (235)U and (238)U) contamination of the environment surrounding phosphogypsum waste heap in Wiślinka (northern Poland).

Science.gov (United States)

Olszewski, Grzegorz; Boryło, Alicja; Skwarzec, Bogdan

2015-08-01

The aim of this work was to determine the uranium concentration ((234)U, (235)U and (238)U) and values of the activity ratio (234)U/(238)U in soil samples collected near phosphogypsum waste heap in Wiślinka (northern Poland). On the basis of the studies it was found that the values of the (234)U/(238)U activity ratio in the analyzed soils collected in the vicinity of phosphogypsum dump in Wiślinka are in most cases close to one and indicate the phosphogypsum origin of the analyzed nuclides. The obtained results of uranium concentrations are however much lower than in previous years before closing of the phosphogypsum stockpile. After this process and covering the phosphogypsum stockpile in Wiślinka with sewage sludge, phosphogypsum particles are successfully immobilized. In the light of the results the use of phosphate fertilizers seems to be a major problem. Prolonged and heavy rains can cause leaching accumulated uranium isotopes in the phosphogypsum stockpile, which will be washed into the Martwa Wisła and on the fields in the immediate vicinity of this storage. Copyright © 2015 Elsevier Ltd. All rights reserved.

A Quantitative Assessment of Factors Affecting the Technological Development and Adoption of Companion Diagnostics

Directory of Open Access Journals (Sweden)

Dee eLuo

2016-01-01

Full Text Available Rapid innovation in (epigenetics and biomarker sciences is driving a new drug development and product development pathway, with the personalized medicine era dominated by biologic therapeutics and companion diagnostics. Companion diagnostics (CDx are tests and assays that detect biomarkers and specific mutations to elucidate disease pathways, stratify patient populations, and target drug therapies. CDx can substantially influence the development and regulatory approval for certain high-risk biologics. However, despite the increasingly important role of companion diagnostics in the realization of personalized medicine, in the United States, there are only twenty-three Food and Drug Administration (FDA approved companion diagnostics on the market for eleven unique indications. Personalized medicines have great potential, yet their use is currently constrained. A major factor for this may lie in the increased complexity of the companion diagnostic and corresponding therapeutic development and adoption pathways. Understanding the market dynamics of companion diagnostic/therapeutic (CDx/Rx pairs is important to further development and adoption of personalized medicine. Therefore, data collected on a variety of factors may highlight incentives or disincentives driving the development of companion diagnostics. Statistical analysis for thirty-six hypotheses resulted in two significant relationships and thirty-four non-significant relationships. The sensitivity of the companion diagnostic was the only factor that significantly correlated with the price of the companion diagnostic. This result indicates that while there is regulatory pressure for the diagnostic and pharmaceutical industry to collaborate and co-develop companion diagnostics for the approval of personalized therapeutics, there seems to be a lack of parallel economic collaboration to incentivize development of companion diagnostics.

A Quantitative Assessment of Factors Affecting the Technological Development and Adoption of Companion Diagnostics.

Science.gov (United States)

Luo, Dee; Smith, James A; Meadows, Nick A; Schuh, A; Manescu, Katie E; Bure, Kim; Davies, Benjamin; Horne, Rob; Kope, Mike; DiGiusto, David L; Brindley, David A

2015-01-01

Rapid innovation in (epi)genetics and biomarker sciences is driving a new drug development and product development pathway, with the personalized medicine era dominated by biologic therapeutics and companion diagnostics. Companion diagnostics (CDx) are tests and assays that detect biomarkers and specific mutations to elucidate disease pathways, stratify patient populations, and target drug therapies. CDx can substantially influence the development and regulatory approval for certain high-risk biologics. However, despite the increasingly important role of companion diagnostics in the realization of personalized medicine, in the USA, there are only 23 Food and Drug Administration (FDA) approved companion diagnostics on the market for 11 unique indications. Personalized medicines have great potential, yet their use is currently constrained. A major factor for this may lie in the increased complexity of the companion diagnostic and corresponding therapeutic development and adoption pathways. Understanding the market dynamics of companion diagnostic/therapeutic (CDx/Rx) pairs is important to further development and adoption of personalized medicine. Therefore, data collected on a variety of factors may highlight incentives or disincentives driving the development of companion diagnostics. Statistical analysis for 36 hypotheses resulted in two significant relationships and 34 non-significant relationships. The sensitivity of the companion diagnostic was the only factor that significantly correlated with the price of the companion diagnostic. This result indicates that while there is regulatory pressure for the diagnostic and pharmaceutical industry to collaborate and co-develop companion diagnostics for the approval of personalized therapeutics, there seems to be a lack of parallel economic collaboration to incentivize development of companion diagnostics.

Coalbed methane: new frontier

Energy Technology Data Exchange (ETDEWEB)

Eaton, S.

2003-02-01

There are large numbers of stacked coal seams permeated with methane or natural gas in the Western Canadian Sedimentary Basin, and approximately 20 coalbed methane pilot projects are operating in the area, and brief descriptions of some of them were provided. Coalbed methane reserves have a long life cycle. A definition of coalbed methane can be a permeability challenged reservoir. It is not uncommon for coalbed methane wells to flow water for periods varying from 2 to 6 months after completion before the production of natural gas. A made-in-Canada technological solution is being developed by CDX Canada Inc., along with its American parent company. The techniques used by CDX are a marriage between coal mining techniques and oil and gas techniques. A brief description of coalification was provided. Nexen is participating in the production of gas from an Upper Mannville coal at 1 000-metres depth in a nine-well pilot project. The Alberta Foothills are considered prime exploration area since older coal is carried close to the surface by thrusting. CDX Canada uses cavitation completion in vertical wells. Cavitation consists in setting the casing above the coal seam and drilling ahead under balanced. The design of wells for coalbed methane gas is based on rock and fluid mechanics. Hydraulic fracturing completions is also used, as are tiltmeters. An enhanced coalbed methane recovery pilot project is being conducted by the Alberta Research Council at Fenn-Big Valley, located in central Alberta. It injects carbon dioxide, which shows great potential for the reduction of greenhouse gas emissions. 1 figs.

Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features.

Science.gov (United States)

Zlobec, Inti; Bihl, Michel; Foerster, Anja; Rufle, Alex; Lugli, Alessandro

2011-11-01

CpG island methylator phenotype (CIMP) is being investigated for its role in the molecular and prognostic classification of colorectal cancer patients but is also emerging as a factor with the potential to influence clinical decision-making. We report a comprehensive analysis of clinico-pathological and molecular features (KRAS, BRAF and microsatellite instability, MSI) as well as of selected tumour- and host-related protein markers characterizing CIMP-high (CIMP-H), -low, and -negative colorectal cancers. Immunohistochemical analysis for 48 protein markers and molecular analysis of CIMP (CIMP-H: ≥ 4/5 methylated genes), MSI (MSI-H: ≥ 2 instable genes), KRAS, and BRAF were performed on 337 colorectal cancers. Simple and multiple regression analysis and receiver operating characteristic (ROC) curve analysis were performed. CIMP-H was found in 24 cases (7.1%) and linked (p CIMP-low or -negative cases. Of the 48 protein markers, decreased levels of RKIP (p = 0.0056), EphB2 (p = 0.0045), CK20 (p = 0.002), and Cdx2 (p CIMP-H, independently of MSI status. In addition to the expected clinico-pathological and molecular associations, CIMP-H colorectal cancers are characterized by a loss of protein markers associated with differentiation, and metastasis suppression, and have increased CD8+ T-lymphocytes regardless of MSI status. In particular, Cdx2 loss seems to strongly predict CIMP-H in both microsatellite-stable (MSS) and MSI-H colorectal cancers. Cdx2 is proposed as a surrogate marker for CIMP-H. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

U(VI) sorption on kaolinite. Effects of pH, U(VI) concentration and oxyanions

International Nuclear Information System (INIS)

Liang Gao; Ziqian Yang; Keliang Shi; Xuefeng Wang; Zhijun Guo; Wangsuo Wu

2010-01-01

U(VI) sorption on kaolinite was studied as functions of contact time, pH, U(VI) concentration, solid-to-liquid ratio (m/V) by using a batch experimental method. The effects of sulfate and phosphate on U(VI) sorption were also investigated. It was found that the sorption kinetics of U(VI) can be described by a pseudo-second-order model. Potentiometric titrations at variable ionic strengths indicated that the titration curves of kaolinite were not sensitive to ionic strength, and that the pH of the zero net proton charge (pH PZNPC ) was at 6.9. The sorption of U(VI) on kaolinite increased with pH up to 6.5 and reached a plateau at pH >6.5. The presence of phosphate strongly increased U(VI) sorption especially at pH <5.5, which may be due to formation of ternary surface complexes involving phosphate. In contrast, the presence of sulfate did not cause any apparent effect on U(VI) sorption. A double layer model was used to interpret both results of potentiometric titrations and U(VI) sorption on kaolinite. (author)

Ground water contamination with (238)U, (234)U, (235)U, (226)Ra and (210)Pb from past uranium mining: cove wash, Arizona.

Science.gov (United States)

Dias da Cunha, Kenya Moore; Henderson, Helenes; Thomson, Bruce M; Hecht, Adam A

2014-06-01

The objectives of the study are to present a critical review of the (238)U, (234)U, (235)U, (226)Ra and (210)Pb levels in water samples from the EPA studies (U.S. EPA in Abandoned uranium mines and the Navajo Nation: Red Valley chapter screening assessment report. Region 9 Superfund Program, San Francisco, 2004, Abandoned uranium mines and the Navajo Nation: Northern aum region screening assessment report. Region 9 Superfund Program, San Francisco, 2006, Health and environmental impacts of uranium contamination, 5-year plan. Region 9 Superfund Program, San Franciso, 2008) and the dose assessment for the population due to ingestion of water containing (238)U and (234)U. The water quality data were taken from Sect. "Data analysis" of the published report, titled Abandoned Uranium Mines Project Arizona, New Mexico, Utah-Navajo Lands 1994-2000, Project Atlas. Total uranium concentration was above the maximum concentration level for drinking water (7.410-1 Bq/L) in 19 % of the water samples, while (238)U and (234)U concentrations were above in 14 and 17 % of the water samples, respectively. (226)Ra and (210)Pb concentrations in water samples were in the range of 3.7 × 10(-1) to 5.55 × 102 Bq/L and 1.11 to 4.33 × 102 Bq/L, respectively. For only two samples, the (226)Ra concentrations exceeded the MCL for total Ra for drinking water (0.185 Bq/L). However, the (210)Pb/(226)Ra ratios varied from 0.11 to 47.00, and ratios above 1.00 were observed in 71 % of the samples. Secular equilibrium of the natural uranium series was not observed in the data record for most of the water samples. Moreover, the (235)U/(total)U mass ratios ranged from 0.06 to 5.9 %, and the natural mass ratio of (235)U to (total)U (0.72 %) was observed in only 16 % of the water samples, ratios above or below the natural ratio could not be explained based on data reported by U.S. EPA. In addition, statistical evaluations showed no correlations among the distribution of the radionuclide concentrations

77 FR 22623 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing of Proposed Rule Change To...

Science.gov (United States)

2012-04-16

..., Panama, Peru, South Africa, the Philippines, Turkey, Russia, Ukraine and Mexico. CDX.EM Contracts... to [email protected] . Please include File Number SR-ICC-2012-04 on the subject line. Paper Comments Send paper comments in triplicate to Elizabeth M. Murphy, Secretary, Securities and Exchange...

Ultrasoft x-ray imaging system for the National Spherical Torus Experiment

Science.gov (United States)

Stutman, D.; Finkenthal, M.; Soukhanovskii, V.; May, M. J.; Moos, H. W.; Kaita, R.

1999-01-01

A spectrally resolved ultrasoft x-ray imaging system, consisting of arrays of high resolution (the National Spherical Torus Experiment. Initially, three poloidal arrays of diodes filtered for C 1s-np emission will be implemented for fast tomographic imaging of the colder start-up plasmas. Later on, mirrors tuned to the C Lyα emission will be added in order to enable the arrays to "see" the periphery through the hot core and to study magnetohydrodynamic activity and impurity transport in this region. We also discuss possible core diagnostics, based on tomographic imaging of the Lyα emission from the plume of recombined, low Z impurity ions left by neutral beams or fueling pellets. The arrays can also be used for radiated power measurements and to map the distribution of high Z impurities injected for transport studies. The performance of the proposed system is illustrated with results from test channels on the CDX-U spherical torus at Princeton Plasma Physics Laboratory.

Investigating Uranium Mobility Using Stable Isotope Partitioning of 238U/235U and a Reactive Transport Model

Science.gov (United States)

Bizjack, M.; Johnson, T. M.; Druhan, J. L.; Shiel, A. E.

2015-12-01

We report a numerical reactive transport model which explicitly incorporates the effectively stable isotopes of uranium (U) and the factors that influence their partitioning in bioactive systems. The model reproduces trends observed in U isotope ratios and concentration measurements from a field experiment, thereby improving interpretations of U isotope ratios as a tracer for U reactive transport. A major factor contributing to U storage and transport is its redox state, which is commonly influenced by the availability of organic carbon to support metal-reducing microbial communities. Both laboratory and field experiments have demonstrated that biogenic reduction of U(VI) fractionates the stable isotope ratio 238U/235U, producing an isotopically heavy solid U(IV) product. It has also been shown that other common reactive transport processes involving U do not fractionate isotopes to a consistently measurable level, which suggests the capacity to quantify the extent of bioreduction occurring in groundwater containing U using 238U/235U ratios. A recent study of a U bioremediation experiment at the Rifle IFRC site (Colorado, USA) applied Rayleigh distillation models to quantify U stable isotope fractionation observed during acetate amendment. The application of these simplified models were fit to the observations only by invoking a "memory-effect," or a constant source of low-concentration, unfractionated U(VI). In order to more accurately interpret the measured U isotope ratios, we present a multi-component reactive transport model using the CrunchTope software. This approach is capable of quantifying the cycling and partitioning of individual U isotopes through a realistic network of transport and reaction pathways including reduction, oxidation, and microbial growth. The model incorporates physical heterogeneity of the aquifer sediments through zones of decreased permeability, which replicate the observed bromide tracer, major ion chemistry, U concentration, and U

Enzymatic reduction of U(VI) in groundwaters; Reduction enzymatique de U(VI) dans des eaux souterraines

Energy Technology Data Exchange (ETDEWEB)

Addelouas, A.; Gong, W. [Center for Radioactive Waste Management, Advanced Materials Laboratory, 1001 University, Albuquerque (United States); Lutze, W.; Nuttall, E. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Chemical and Nuclear Engineering; Fritz, B.; Crovisier, J.L. [Centre National de la Recherche Scientifique (CNRS), 67 - Strasbourg (France). Centre de Sedimentologie et Geochimie de la Surface

1999-03-01

The use of enzymatic reduction of U(VI) in remediation of groundwater contaminated with U(VI) is receiving considerable attention. Certain strains of bacteria can combine the oxidation of an organic compound to the reduction of U(VI) to U(IV), which precipitates as uraninite. In the present study, we tested the reduction of U(VI) in groundwaters with various origins and compositions. In all groundwaters u(VI) was reduced by sulfate reducing bacteria that had been activated by ethanol and tri-metaphosphate. The reduction rate of U(VI) depends on sulfate concentration in water and the abundance of bacteria in the system. This work shows that bacteria capable of U(VI) reduction are ubiquitous in nature, and suggests the possibility of a large application of the enzymatic reduction of U(VI) for in situ clean up of groundwaters contaminated with uranium. (authors) 12 refs.

International Aviation: Competition Issues in the U.S. - U.K. Market

Science.gov (United States)

1997-06-04

Access to London's Heathrow Airport is important to any airline that desires to : be a major participant in the transatlantic market. Current U.S. bilateral : aviation agreement with the United Kingdom restricts the number of U.S. airlines : that can...

Isothermal section of diagram of U-Mo-B and U-Re-B systems

International Nuclear Information System (INIS)

Val'ovka, I.P.; Kuz'ma, Yu.B.

1986-01-01

The methods of X-ray analysis are used to study the U-Mo-B and U-Re-B systems and to plot phase equilibrium diagrams at 1000 and 800 deg C, respectively. A formation of boride UMoB 4 (structure of the ThMoB 4 type) is confirmed in the U-Mo-B system and new compounds are found: U 2 MoB 6 (rhombic structure of the Y 2 ReB 6 type, a=0.9301(9), b=1.1434(11), c=0.3678(4) nm), ∼UMo 2 B 6 and ∼ UMo 4 B 4 with unknown structures. In the U-Re-B system besides previously known boride UReB 4 (the ThMoB 4 structure type), new ones are obtained: U 2 ReB 6 (Y 2 ReB 6 type, a=0.9373(9), b=1.1529(13), c0.3653(4) nm) and UReB 3 (hexagonal structure of the proper type, a=0.5083(1), c=0.5095(1) nm)

Princeton Plasma Physics Laboratory annual report, October 1, 1983-September 30, 1984

Energy Technology Data Exchange (ETDEWEB)

Phillips, C.A. (ed.)

1984-01-01

Progress made during this reporting period is reported for each of the following areas: (1) principal parameters achieved in experimental devices, (2) TFTR, (3) PLT, (4) PBX, (5) S-1 Spheromak, (6) advanced concepts Torus-1, (7) x-ray laser studies, (8) theory, (9) tokamak modeling, (10) reactor studies, (11) spin-polarized fusion program, (12) tokamak fusion core experiment, and (13) engineering. (MOW)

Parallel-beam correlation technique for measuring density fluctuations in plasmas with strong magnetic shear

International Nuclear Information System (INIS)

Jacobson, A.R.

1981-04-01

A laser diagnostic scheme is described which facilitates localization of density fluctuations along the line of sight. The method exploits both the generally observed anisotropy of density fluctuations in low-beta plasmas, as well as the twisting of the magnetic field which occurs across the minor diameter of reversed-field pinches, spheromaks, etc. Both interferometric and schlieren variations are discussed

Princeton Plasma Physics Laboratory annual report, October 1, 1983-September 30, 1984

International Nuclear Information System (INIS)

Phillips, C.A.

1984-01-01

Progress made during this reporting period is reported for each of the following areas: (1) principal parameters achieved in experimental devices, (2) TFTR, (3) PLT, (4) PBX, (5) S-1 Spheromak, (6) advanced concepts Torus-1, (7) x-ray laser studies, (8) theory, (9) tokamak modeling, (10) reactor studies, (11) spin-polarized fusion program, (12) tokamak fusion core experiment, and (13) engineering

Princeton Plasma Physics Laboratory: Annual report, October 1, 1986--September 30, 1987

International Nuclear Information System (INIS)

1987-01-01

This report contains papers on the following topics: Principle Parameters Achieved in Experimental Devices (FY87); Tokamak Fusion Test Reactor; Princeton Beta Experiment-Modification; S-1 Spheromak; Current-Drive Experiment; X-Ray Laser Studies; Theoretical Division; Tokamak Modeling; Compact Ignition Tokamak; Engineering Department; Project Planning and Safety Office; Quality Assurance and Reliability; Administrative Operations; and PPPL Patent Invention Disclosures (FY87)

Azimuthal Anisotropy in U +U and Au +Au Collisions at RHIC

Science.gov (United States)

Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alekseev, I.; Alford, J.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Averichev, G. S.; Banerjee, A.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bhattarai, P.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Bouchet, J.; Brandin, A. V.; Bunzarov, I.; Burton, T. P.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Campbell, J. M.; Cebra, D.; Cervantes, M. C.; Chakaberia, I.; Chaloupka, P.; Chang, Z.; Chattopadhyay, S.; Chen, J. H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H. J.; Das, S.; De Silva, L. C.; Debbe, R. R.; Dedovich, T. G.; Deng, J.; Derevschikov, A. A.; di Ruzza, B.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J. L.; Draper, J. E.; Du, C. M.; Dunkelberger, L. E.; Dunlop, J. C.; Efimov, L. G.; Engelage, J.; Eppley, G.; Esha, R.; Evdokimov, O.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Fedorisin, J.; Feng, Z.; Filip, P.; Fisyak, Y.; Flores, C. E.; Fulek, L.; Gagliardi, C. A.; Garand, D.; Geurts, F.; Gibson, A.; Girard, M.; Greiner, L.; Grosnick, D.; Gunarathne, D. S.; Guo, Y.; Gupta, S.; Gupta, A.; Guryn, W.; Hamad, A.; Hamed, A.; Haque, R.; Harris, J. W.; He, L.; Heppelmann, S.; Heppelmann, S.; Hirsch, A.; Hoffmann, G. W.; Hofman, D. J.; Horvat, S.; Huang, H. Z.; Huang, B.; Huang, X.; Huck, P.; Humanic, T. J.; Igo, G.; Jacobs, W. W.; Jang, H.; Jiang, K.; Judd, E. G.; Kabana, S.; Kalinkin, D.; Kang, K.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Khan, Z. H.; Kikola, D. P.; Kisel, I.; Kisiel, A.; Koetke, D. D.; Kollegger, T.; Kosarzewski, L. K.; Kotchenda, L.; Kraishan, A. F.; Kravtsov, P.; Krueger, K.; Kulakov, I.; Kumar, L.; Kycia, R. A.; Lamont, M. A. C.; Landgraf, J. M.; Landry, K. D.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, W.; Li, Y.; Li, C.; Li, Z. M.; Li, X.; Li, X.; Lisa, M. A.; Liu, F.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, X.; Ma, L.; Ma, R.; Ma, Y. G.; Ma, G. L.; Magdy, N.; Majka, R.; Manion, A.; Margetis, S.; Markert, C.; Masui, H.; Matis, H. S.; McDonald, D.; Meehan, K.; Minaev, N. G.; Mioduszewski, S.; Mohanty, B.; Mondal, M. M.; Morozov, D. A.; Mustafa, M. K.; Nandi, B. K.; Nasim, Md.; Nayak, T. K.; Nigmatkulov, G.; Nogach, L. V.; Noh, S. Y.; Novak, J.; Nurushev, S. B.; Odyniec, G.; Ogawa, A.; Oh, K.; Okorokov, V.; Olvitt, D. L.; Page, B. S.; Pak, R.; Pan, Y. X.; Pandit, Y.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Peterson, A.; Pile, P.; Planinic, M.; Pluta, J.; Poljak, N.; Poniatowska, K.; Porter, J.; Posik, M.; Poskanzer, A. M.; Pruthi, N. K.; Putschke, J.; Qiu, H.; Quintero, A.; Ramachandran, S.; Raniwala, S.; Raniwala, R.; Ray, R. L.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Roy, A.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Sakrejda, I.; Salur, S.; Sandweiss, J.; Sarkar, A.; Schambach, J.; Scharenberg, R. P.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Seger, J.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Sharma, B.; Sharma, M. K.; Shen, W. Q.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Sikora, R.; Simko, M.; Skoby, M. J.; Smirnov, D.; Smirnov, N.; Song, L.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Stepanov, M.; Stock, R.; Strikhanov, M.; Stringfellow, B.; Sumbera, M.; Summa, B. J.; Sun, X.; Sun, X. M.; Sun, Z.; Sun, Y.; Surrow, B.; Svirida, D. N.; Szelezniak, M. A.; Tang, Z.; Tang, A. H.; Tarnowsky, T.; Tawfik, A. N.; Thomas, J. H.; Timmins, A. R.; Tlusty, D.; Tokarev, M.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Tripathy, S. K.; Trzeciak, B. A.; Tsai, O. D.; Ullrich, T.; Underwood, D. G.; Upsal, I.; Van Buren, G.; van Nieuwenhuizen, G.; Vandenbroucke, M.; Varma, R.; Vasiliev, A. N.; Vertesi, R.; Videbaek, F.; Viyogi, Y. P.; Vokal, S.; Voloshin, S. A.; Vossen, A.; Wang, F.; Wang, Y.; Wang, H.; Wang, J. S.; Wang, Y.; Wang, G.; Webb, G.; Webb, J. C.; Wen, L.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y. F.; Xiao, Z.; Xie, W.; Xin, K.; Xu, Y. F.; Xu, N.; Xu, Z.; Xu, Q. H.; Xu, H.; Yang, Y.; Yang, Y.; Yang, C.; Yang, S.; Yang, Q.; Ye, Z.; Yepes, P.; Yi, L.; Yip, K.; Yoo, I.-K.; Yu, N.; Zbroszczyk, H.; Zha, W.; Zhang, X. P.; Zhang, J. B.; Zhang, J.; Zhang, Z.; Zhang, S.; Zhang, Y.; Zhang, J. L.; Zhao, F.; Zhao, J.; Zhong, C.; Zhou, L.; Zhu, X.; Zoulkarneeva, Y.; Zyzak, M.; STAR Collaboration

2015-11-01

Collisions between prolate uranium nuclei are used to study how particle production and azimuthal anisotropies depend on initial geometry in heavy-ion collisions. We report the two- and four-particle cumulants, v2{2 } and v2{4 }, for charged hadrons from U +U collisions at √{sNN }=193 GeV and Au +Au collisions at √{sNN}=200 GeV . Nearly fully overlapping collisions are selected based on the energy deposited by spectators in zero degree calorimeters (ZDCs). Within this sample, the observed dependence of v2{2 } on multiplicity demonstrates that ZDC information combined with multiplicity can preferentially select different overlap configurations in U +U collisions. We also show that v2 vs multiplicity can be better described by models, such as gluon saturation or quark participant models, that eliminate the dependence of the multiplicity on the number of binary nucleon-nucleon collisions.

Azimuthal Anisotropy in U+U and Au+Au Collisions at RHIC.

Science.gov (United States)

Adamczyk, L; Adkins, J K; Agakishiev, G; Aggarwal, M M; Ahammed, Z; Alekseev, I; Alford, J; Aparin, A; Arkhipkin, D; Aschenauer, E C; Averichev, G S; Banerjee, A; Bellwied, R; Bhasin, A; Bhati, A K; Bhattarai, P; Bielcik, J; Bielcikova, J; Bland, L C; Bordyuzhin, I G; Bouchet, J; Brandin, A V; Bunzarov, I; Burton, T P; Butterworth, J; Caines, H; Calderón de la Barca Sánchez, M; Campbell, J M; Cebra, D; Cervantes, M C; Chakaberia, I; Chaloupka, P; Chang, Z; Chattopadhyay, S; Chen, J H; Chen, X; Cheng, J; Cherney, M; Christie, W; Contin, G; Crawford, H J; Das, S; De Silva, L C; Debbe, R R; Dedovich, T G; Deng, J; Derevschikov, A A; di Ruzza, B; Didenko, L; Dilks, C; Dong, X; Drachenberg, J L; Draper, J E; Du, C M; Dunkelberger, L E; Dunlop, J C; Efimov, L G; Engelage, J; Eppley, G; Esha, R; Evdokimov, O; Eyser, O; Fatemi, R; Fazio, S; Federic, P; Fedorisin, J; Feng, Z; Filip, P; Fisyak, Y; Flores, C E; Fulek, L; Gagliardi, C A; Garand, D; Geurts, F; Gibson, A; Girard, M; Greiner, L; Grosnick, D; Gunarathne, D S; Guo, Y; Gupta, S; Gupta, A; Guryn, W; Hamad, A; Hamed, A; Haque, R; Harris, J W; He, L; Heppelmann, S; Heppelmann, S; Hirsch, A; Hoffmann, G W; Hofman, D J; Horvat, S; Huang, H Z; Huang, B; Huang, X; Huck, P; Humanic, T J; Igo, G; Jacobs, W W; Jang, H; Jiang, K; Judd, E G; Kabana, S; Kalinkin, D; Kang, K; Kauder, K; Ke, H W; Keane, D; Kechechyan, A; Khan, Z H; Kikola, D P; Kisel, I; Kisiel, A; Koetke, D D; Kollegger, T; Kosarzewski, L K; Kotchenda, L; Kraishan, A F; Kravtsov, P; Krueger, K; Kulakov, I; Kumar, L; Kycia, R A; Lamont, M A C; Landgraf, J M; Landry, K D; Lauret, J; Lebedev, A; Lednicky, R; Lee, J H; Li, W; Li, Y; Li, C; Li, Z M; Li, X; Li, X; Lisa, M A; Liu, F; Ljubicic, T; Llope, W J; Lomnitz, M; Longacre, R S; Luo, X; Ma, L; Ma, R; Ma, Y G; Ma, G L; Magdy, N; Majka, R; Manion, A; Margetis, S; Markert, C; Masui, H; Matis, H S; McDonald, D; Meehan, K; Minaev, N G; Mioduszewski, S; Mohanty, B; Mondal, M M; Morozov, D A; Mustafa, M K; Nandi, B K; Nasim, Md; Nayak, T K; Nigmatkulov, G; Nogach, L V; Noh, S Y; Novak, J; Nurushev, S B; Odyniec, G; Ogawa, A; Oh, K; Okorokov, V; Olvitt, D L; Page, B S; Pak, R; Pan, Y X; Pandit, Y; Panebratsev, Y; Pawlik, B; Pei, H; Perkins, C; Peterson, A; Pile, P; Planinic, M; Pluta, J; Poljak, N; Poniatowska, K; Porter, J; Posik, M; Poskanzer, A M; Pruthi, N K; Putschke, J; Qiu, H; Quintero, A; Ramachandran, S; Raniwala, S; Raniwala, R; Ray, R L; Ritter, H G; Roberts, J B; Rogachevskiy, O V; Romero, J L; Roy, A; Ruan, L; Rusnak, J; Rusnakova, O; Sahoo, N R; Sahu, P K; Sakrejda, I; Salur, S; Sandweiss, J; Sarkar, A; Schambach, J; Scharenberg, R P; Schmah, A M; Schmidke, W B; Schmitz, N; Seger, J; Seyboth, P; Shah, N; Shahaliev, E; Shanmuganathan, P V; Shao, M; Sharma, B; Sharma, M K; Shen, W Q; Shi, S S; Shou, Q Y; Sichtermann, E P; Sikora, R; Simko, M; Skoby, M J; Smirnov, D; Smirnov, N; Song, L; Sorensen, P; Spinka, H M; Srivastava, B; Stanislaus, T D S; Stepanov, M; Stock, R; Strikhanov, M; Stringfellow, B; Sumbera, M; Summa, B J; Sun, X; Sun, X M; Sun, Z; Sun, Y; Surrow, B; Svirida, D N; Szelezniak, M A; Tang, Z; Tang, A H; Tarnowsky, T; Tawfik, A N; Thomas, J H; Timmins, A R; Tlusty, D; Tokarev, M; Trentalange, S; Tribble, R E; Tribedy, P; Tripathy, S K; Trzeciak, B A; Tsai, O D; Ullrich, T; Underwood, D G; Upsal, I; Van Buren, G; van Nieuwenhuizen, G; Vandenbroucke, M; Varma, R; Vasiliev, A N; Vertesi, R; Videbaek, F; Viyogi, Y P; Vokal, S; Voloshin, S A; Vossen, A; Wang, F; Wang, Y; Wang, H; Wang, J S; Wang, Y; Wang, G; Webb, G; Webb, J C; Wen, L; Westfall, G D; Wieman, H; Wissink, S W; Witt, R; Wu, Y F; Xiao, Z; Xie, W; Xin, K; Xu, Y F; Xu, N; Xu, Z; Xu, Q H; Xu, H; Yang, Y; Yang, Y; Yang, C; Yang, S; Yang, Q; Ye, Z; Yepes, P; Yi, L; Yip, K; Yoo, I-K; Yu, N; Zbroszczyk, H; Zha, W; Zhang, X P; Zhang, J B; Zhang, J; Zhang, Z; Zhang, S; Zhang, Y; Zhang, J L; Zhao, F; Zhao, J; Zhong, C; Zhou, L; Zhu, X; Zoulkarneeva, Y; Zyzak, M

2015-11-27

Collisions between prolate uranium nuclei are used to study how particle production and azimuthal anisotropies depend on initial geometry in heavy-ion collisions. We report the two- and four-particle cumulants, v_{2}{2} and v_{2}{4}, for charged hadrons from U+U collisions at sqrt[s_{NN}]=193  GeV and Au+Au collisions at sqrt[s_{NN}]=200  GeV. Nearly fully overlapping collisions are selected based on the energy deposited by spectators in zero degree calorimeters (ZDCs). Within this sample, the observed dependence of v_{2}{2} on multiplicity demonstrates that ZDC information combined with multiplicity can preferentially select different overlap configurations in U+U collisions. We also show that v_{2} vs multiplicity can be better described by models, such as gluon saturation or quark participant models, that eliminate the dependence of the multiplicity on the number of binary nucleon-nucleon collisions.

Colorimetric on-line control of U

International Nuclear Information System (INIS)

Perez, J.J.; Boisde, G.; Dedaldechamp, P.; Dureault, B.

The instrumentation developed for the automatic colorimetric control of U is presented. Two techniques are used: absorptiometry of U ions using optical probes enabling to measure in situ the solutions containing 0.5 g U(IV)/l or 1 g U(VI)/l; colorimetry of the U-DBM complexe after separation of U by TOPO (this technique is applied to the control of U at the ppm level). The automatic devices used are described. They are experimented in laboratory or in pilot-plant [fr

Žalba u upravnom sporu

OpenAIRE

Đerđa, Dario; Galić, Ante

2014-01-01

U radu se razmatra uvođenje dvostupanjskog sustava upravnog sudovanja u Hrvatskoj 2010. godine. Utvrđuje se potreba uvođenja žalbe u upravnosudski sustav te se pojedinačno analiziraju ograničenja vezana uz ovaj institut. Najprije se razmatra ograničenje izjavljivanja žalbe protiv rješenja, zatim stavljanje nekih prvostupanjskih upravnih sporova u nadležnost Visokog upravnog suda Republike Hrvatske te, konačno, ograničenja izjavljivanja žalbe na neke vrste presuda upravnih sudova. Nadalje se u...

Safety assessment for the S-1 Spheromak

International Nuclear Information System (INIS)

Ellis, R. Jr.; Stencel, J.R.

1984-02-01

The S-1 machine is part of the Magnetic Fusion Program. The goal of the Magnetic Fusion Program is to develop and demonstrate the practical application of fusion. S-1 is an experimental device which will provide an essential link in the research effort aiming at the realization of fusion power

Optogalvanic measurement of isotope shifts of doubly ionized uranium (U III) made using natural-U samples

International Nuclear Information System (INIS)

Piyakis, K.N.; Gagne, J.

1989-01-01

An efficient method of identifying 235 U III (in natural-U samples), with the help of the optogalvanic effect in a hollow-cathode discharge, is presented. The use of this method enabled us to carry out the measurement of isotope shifts and the preliminary investigation of hyperfine structures of U III. The 238 U-- 235 U shifts for the 591.313-, 586.045-, and 610.497-nm U III lines are found to be 921(3), 417(6), and 392(12) mK, respectively

Theoretical modeling of the uranium 4f XPS for U(VI) and U(IV) oxides

Energy Technology Data Exchange (ETDEWEB)

Bagus, Paul S. [Department of Chemistry, University of North Texas, Denton, Texas 76203-5017 (United States); Nelin, Connie J. [Consulting and Services, 6008 Maury' s Trail, Austin, Texas 78730 (United States); Ilton, Eugene S. [Pacific Northwest National Laboratory, Richland, Washington 99352 (United States)

2013-12-28

A rigorous study is presented of the physical processes related to X-Ray photoelectron spectroscopy, XPS, in the 4f level of U oxides, which, as well as being of physical interest in themselves, are representative of XPS in heavy metal oxides. In particular, we present compelling evidence for a new view of the screening of core-holes that extends prior understandings. Our analysis of the screening focuses on the covalent mixing of high lying U and O orbitals as opposed to the, more common, use of orbitals that are nominally pure U or pure O. It is shown that this covalent mixing is quite different for the initial and final, core-hole, configurations and that this difference is directly related to the XPS satellite intensity. Furthermore, we show that the high-lying U d orbitals as well as the U(5f) orbital may both contribute to the core-hole screening, in contrast with previous work that has only considered screening through the U(5f) shell. The role of modifying the U-O interaction by changing the U-O distance has been investigated and an unexpected correlation between U-O distance and XPS satellite intensity has been discovered. The role of flourite and octahedral crystal structures for U(IV) oxides has been examined and relationships established between XPS features and the covalent interactions in the different structures. The physical views of XPS satellites as arising from shake processes or as arising from ligand to metal charge transfers are contrasted; our analysis provides strong support that shake processes give a more fundamental physical understanding than charge transfer. Our theoretical studies are based on rigorous, strictly ab initio determinations of the electronic structure of embedded cluster models of U oxides with formal U(VI) and U(IV) oxidation states. Our results provide a foundation that makes it possible to establish quantitative relationships between features of the XPS spectra and materials properties.

Theoretical modeling of the uranium 4f XPS for U(VI) and U(IV) oxides

Science.gov (United States)

Bagus, Paul S.; Nelin, Connie J.; Ilton, Eugene S.

2013-12-01

A rigorous study is presented of the physical processes related to X-Ray photoelectron spectroscopy, XPS, in the 4f level of U oxides, which, as well as being of physical interest in themselves, are representative of XPS in heavy metal oxides. In particular, we present compelling evidence for a new view of the screening of core-holes that extends prior understandings. Our analysis of the screening focuses on the covalent mixing of high lying U and O orbitals as opposed to the, more common, use of orbitals that are nominally pure U or pure O. It is shown that this covalent mixing is quite different for the initial and final, core-hole, configurations and that this difference is directly related to the XPS satellite intensity. Furthermore, we show that the high-lying U d orbitals as well as the U(5f) orbital may both contribute to the core-hole screening, in contrast with previous work that has only considered screening through the U(5f) shell. The role of modifying the U-O interaction by changing the U-O distance has been investigated and an unexpected correlation between U-O distance and XPS satellite intensity has been discovered. The role of flourite and octahedral crystal structures for U(IV) oxides has been examined and relationships established between XPS features and the covalent interactions in the different structures. The physical views of XPS satellites as arising from shake processes or as arising from ligand to metal charge transfers are contrasted; our analysis provides strong support that shake processes give a more fundamental physical understanding than charge transfer. Our theoretical studies are based on rigorous, strictly ab initio determinations of the electronic structure of embedded cluster models of U oxides with formal U(VI) and U(IV) oxidation states. Our results provide a foundation that makes it possible to establish quantitative relationships between features of the XPS spectra and materials properties.

IAEA CIELO Evaluation of Neutron-induced Reactions on 235U and 238U Targets

Science.gov (United States)

Capote, R.; Trkov, A.; Sin, M.; Pigni, M. T.; Pronyaev, V. G.; Balibrea, J.; Bernard, D.; Cano-Ott, D.; Danon, Y.; Daskalakis, A.; Goričanec, T.; Herman, M. W.; Kiedrowski, B.; Kopecky, S.; Mendoza, E.; Neudecker, D.; Leal, L.; Noguere, G.; Schillebeeckx, P.; Sirakov, I.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.

2018-02-01

Evaluations of nuclear reaction data for the major uranium isotopes 238U and 235U were performed within the scope of the CIELO Project on the initiative of the OECD/NEA Data Bank under Working Party on Evaluation Co-operation (WPEC) Subgroup 40 coordinated by the IAEA Nuclear Data Section. Both the mean values and covariances are evaluated from 10-5 eV up to 30 MeV. The resonance parameters of 238U and 235U were re-evaluated with the addition of newly available data to the existing experimental database. The evaluations in the fast neutron range are based on nuclear model calculations with the code EMPIRE-3.2 Malta above the resonance range up to 30 MeV. 235U(n,f), 238U(n,f), and 238U(n,γ) cross sections and 235U(nth,f) prompt fission neutron spectrum (PFNS) were evaluated within the Neutron Standards project and are representative of the experimental state-of-the-art measurements. The Standards cross sections were matched in model calculations as closely as possible to guarantee a good predictive power for cross sections of competing neutron scattering channels. 235U(n,γ) cross section includes fluctuations observed in recent experiments. 235U(n,f) PFNS for incident neutron energies from 500 keV to 20 MeV were measured at Los Alamos Chi-Nu facility and re-evaluated using all available experimental data. While respecting the measured differential data, several compensating errors in previous evaluations were identified and removed so that the performance in integral benchmarks was restored or improved. Covariance matrices for 235U and 238U cross sections, angular distributions, spectra and neutron multiplicities were evaluated using the GANDR system that combines experimental data with model uncertainties. Unrecognized systematic uncertainties were considered in the uncertainty quantification for fission and capture cross sections above the thermal range, and for neutron multiplicities. Evaluated files were extensively benchmarked to ensure good performance in

Review of the thermodynamics of the U--C, Pu--C, and U--Pu--C systems

International Nuclear Information System (INIS)

Tetenbaum, M.; Sheth, A.; Olson, W.

1975-06-01

Thermodynamic properties such as enthalpy, heat capacity, entropy, heat and free energy of formation, and vaporization behavior are presented for the U--C, Pu--C, and U--Pu--C systems. These properties are of interest to scientists and engineers involved in the expanding field of advanced fuel LMFBR systems. The information on these systems has been derived largely from the discussions of the IAEA Panel on the assessment of thermodynamic properties of the U--C, Pu--C, and U--Pu--C systems. (U.S.)

uPAR as anti-cancer target

DEFF Research Database (Denmark)

Lund, Ida K; Illemann, Martin; Thurison, Tine

2011-01-01

, and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models....

Dissolution behaviour of 238U, 234U and 230Th deposited on filters from personal dosemeters

International Nuclear Information System (INIS)

Beckova, V.; Malatova, I.

2008-01-01

Kinetics of dissolution of 238 U, 234 U and 230 Th dust deposited on filters from personal alpha dosemeters was studied by means of a 26-d in vitro dissolution test with a serum ultra-filtrate simulant. Dosemeters had been used by miners at the uranium mine 'Dolni Rozinka' at Rozna, Czech Republic. The sampling flow-rate as declared by the producer is 4 l h -1 and the sampling period is typically 1 month. Studied filters contained 125 ± 6 mBq 238 U in equilibrium with 234 U and 230 Th; no 232 Th series nuclides were found. Half-time of rapid dissolution of 1.4 d for 238 U and 234 U and slow dissolution half-times of 173 and 116 d were found for 238 U and 234 U, respectively. No detectable dissolution of 230 Th was found. (authors)

Multichannel interactions in the (1σ/sub g/)2(1σ/sub u/)nsσ, ndλ(3Σ+/sub u/,3Σ+/sub u/,3Pi/sub u/,3Δ/sub u/) Rydberg structures of He2

International Nuclear Information System (INIS)

Ginter, D.S.; Ginter, M.L.

1988-01-01

We show that a minimal parameter coupled channel model based on eigenquantum defect theory can reproduce quantitatively the known Rydberg structures associated with six channels of nsσ,ndλ( 3 Σ + /sub u/, 3 Σ + /sub u/, 3 Pi/sub u/, 3 Δ/sub u/) v = 0 ancestry in He 2 . Except for a few levels affected by accidental perturbations, these extensive level structures can be reproduced to within average experimental uncertainties. Previously unreported spectral analyses for transitions to the b 3 Pi/sub g/ state from rotational levels in the nl channel segments with n = 12--18 are included in this work. These spectral transitions were predicted and observed in the early stages of this investigation and were used to determine a number of new energy levels for the n = 3--18 data base used in subsequent calculations. The model uses a U matrix modified slightly from a Hund's case (b) to case (d) transformation and energy dependent eigenquantum defects μ/sub α/. Discussed in detail is a specific 14 parameter representation for ∼500 energy levels in which 2 parameters modify U to include interactions between ns and nd and 12 parameters describe the variation of the μ/sub α/'s with energy

A contribution to the kinetic study of the metatectic reaction U+U3Si2→U3Si

International Nuclear Information System (INIS)

Arroyo Ruiperez, J.; Esteban Hernandez, J. A.

1962-01-01

An experimental study has been made to decide upon the advantages and drawbacks of the different methods and reagents employed in the metallography of U-Si alloys. It has been observed that all samples thermally treated to form the epsilon-phase undergo from the beginning a coalescence of the U 3 Si 2 particles, which makes practically useless any fine state of dispersion that might be present originally, as recommended by some authors. The coalescence of the U 3 Si 2 particle decreases the surface available for reaction and consequently the reaction rate. (Author) 7 refs

Photochemistry of U(BH/sub 4/)/sub 4/ and U(BD/sub 4/)/sub 4/

Energy Technology Data Exchange (ETDEWEB)

Paine, R T; Schonberg, P R; Light, R W [New Mexico Univ., Albuquerque (USA). Dept. of Chemistry; Danen, W C; Freund, S M

1979-01-01

U(BH/sub 4/)/sub 4/ and U(BD/sub 4/)/sub 4/ are observed to undergo complex degradation reactions promoted by broadband UV radiation. The primary products of these reactions appear to be U(BH/sub 4/)/sub 3/, B/sub 2/H/sub 6/, H/sub 2/, U(BD/sub 4/)/sub 3/, B/sub 2/D/sub 6/ and D/sub 2/. Further, U(BD/sub 4/)/sub 4/ undergoes a related decomposition reaction under the influence of CO/sub 2/ laser irradiation at 924.97 cm/sup -1/.

Uranium contents and 234U/238U activity ratios of modern and fossil marine bivalle molluscan shells

International Nuclear Information System (INIS)

Mitsuda, Hiroshi

1984-01-01

Uranium contents and 234 U/ 238 U activity ratios in modern and fossil marine bivalle molluscan shells were measured by alpha-spectrometry. Uranium contents and 234 U/ 238 U activity ratios in modern shells were averaged to be 0.266 (dpm/g), and 1.18, respectively and those in fossil shells were averaged to be 0.747 (dpm/g), and 1.19, respectivily. Uranium contents in fossil shells were obviously higher than those in modern shells. It can be explained by the addition of uranium to shell during the deposition. In fossil shells, 234 U/ 238 U activity ratio decreases as 238 U content increases the same tendency is not found in modern shells. The author proposed a mechanism of selective loss of 238 U from the fossil shells for the explanation of this tendency. The height activity ratio of 234 U/ 238 U measured on the fossil shells than that measured on the modern shells, also support the selective loss of 238 U from the fossil shells. (author)

Oltar Sv. Jeronima u crkvi Sv. Šime u Zadru i radionica Bettamelli

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Bojan Goja

2012-12-01

Full Text Available U radu se na temelju arhivskih podataka govori o oltaru Sv. Jeronima u crkvi Sv. Šime u Zadru. Od ranije se zna da je oltar dala podići i o njegovu se uređenju brinula bratovština hrvatskih i albanskih vojnika (Croatti a cavallo i Soldati Albanesi u službi Mletačke Republike, osnovana 1675. godine u Zadru. Novim je arhivskim istraživanjima utvrđeno da je dana 26. rujna 1694. godine bratovština odobrila izdatak u iznosu od 200 srebrnih dukata, namijenjenih venecijanskim klesarima braći Bettamelli kao predujam za izradu oltara te da su radovi na njegovu podizanju započeti u travnju 1696. godine. Na temelju zapisa o gradnji oltara iznijeta je pretpostavka da se grb na istočnom pilastru stipesa oltara, ranije povezivan s predstavnicima obitelji Civran, odnosi na zadarskog plemića i istaknutog zapovjednika u mletačkoj vojsci, Šimuna Fanfognu (Zadar, 7. travnja 1663. - Lendinara, 6. ožujka 1707. koji je obavljao i dužnost prokuratora oltara. Brojni radovi na uređenju oltara i kapele Sv. Jeronima obavljani su i tijekom čitavog 18. stoljeća, a na njima su bili uposleni brojni mjesni majstori različitih struka: graditelji Antonio Piovesana (1742. i Antonio Bernardini (1789., oltarist Girolamo Picco (1756., marangon Domenico Tomaselli (1743., kovač Antonelli (1744. te zlatari Zorzi Cullisich (1738., Nicolò Giurovich (1752. i Giuseppe Rado (1755.. Donose se još neke zanimljivosti vezane uz uređenje oltara i djelovanje bratovštine Sv. Jeronima.

Dissolution behaviour of 238U, 234U and 230Th deposited on filters from personal dosemeters.

Science.gov (United States)

Becková, Vera; Malátová, Irena

2008-01-01

Kinetics of dissolution of (238)U, (234)U and (230)Th dust deposited on filters from personal alpha dosemeters was studied by means of a 26-d in vitro dissolution test with a serum ultrafiltrate simulant. Dosemeters had been used by miners at the uranium mine 'Dolní Rozínka' at Rozná, Czech Republic. The sampling flow-rate as declared by the producer is 4 l h(-1) and the sampling period is typically 1 month. Studied filters contained 125 +/- 6 mBq (238)U in equilibrium with (234)U and (230)Th; no (232)Th series nuclides were found. Half-time of rapid dissolution of 1.4 d for (238)U and (234)U and slow dissolution half-times of 173 and 116 d were found for (238)U and (234)U, respectively. No detectable dissolution of (230)Th was found.

MBE growth of Topological Isolators based on strained semi-metallic HgCdTe layers

Science.gov (United States)

Grendysa, J.; Tomaka, G.; Sliz, P.; Becker, C. R.; Trzyna, M.; Wojnarowska-Nowak, R.; Bobko, E.; Sheregii, E. M.

2017-12-01

Particularities of Molecular Beam Epitaxial (MBE) technology for the growth of Topological Insulators (TI) based on the semi-metal Hg1-xCdx Te are presented. A series of strained layers grown on GaAs substrates with a composition close to the 3D Dirac point were studied. The composition of the layers was verified by means of the position of the E1 maximum in optical reflectivity in the visible region. The surface morphology was determined via atomic force and electron microscopy. Magneto-transport measurements show quantized Hall resistance curves and Shubnikov de Hass oscillations (up to 50 K). It has been demonstrated that a well-developed MBE technology enables one to grow strained Hg1-xCdx Te layers on GaAs/CdTe substrates with a well-defined composition near the 3D Dirac point and consequently allows one to produce a 3D topological Dirac semimetal - 3D analogy of graphene - for future applications.

Helicobacter pylori as a crucial factor in intestinal metaplasia development of gastric mucosa

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Sergii Vernygorodskyi

2016-06-01

Full Text Available Helicobacter pylori (H. pylori is detected on the surface of gastric epithelium and in goblet cells, predominantly in patients with chronic atrophic gastritis and incomplete intestinal metaplasia (IM. H. pylori infection persistence leads to the formation of gastrointestinal phenotype of IM. H. pylori can be considered as an etiological factor of IM. It inhibits the expression of SOX2 in gastric epithelial cells, hence activating transcription factor CDX2 as a counterpart to MUC5AC gene inhibition and MUC2 gene induction. Thus, in metaplastic cells, programming differentiation after intestinal phenotype will develop. The role of H. pylori in the origin of intestinal metaplasia of gastric mucosa was defined in this study to elucidate the probable mechanism of cell reprogramming. The activation of CDX2, with simultaneous inactivation and decreased number of genes (e.g., SHH, SOX2, and RUNX3 responsible for gastric differentiation, was identified to cause the appearance of IM.

Massless Dirac fermions in semimetal HgCdTe

Science.gov (United States)

Marchewka, M.; Grendysa, J.; Żak, D.; Tomaka, G.; Śliż, P.; Sheregii, E. M.

2017-01-01

Magneto-transport results obtained for the strained 100 nm thick Hg1-x CdxTe (x=0.135) layer grown by MBE on the CdTe/GaAs substrate are interpreted by the 8×8 kp model with the in-plane tensile strain. The dispersion relation for the investigated structure proves that the Dirac point is located in the gap caused by the strain. It is also shown that the fan of the Landau Levels (LL's) energy calculated for topological protected surface states for the studied HgCdTe alloy corresponds to the fan of the LL's calculated using the graphen-like Hamiltonian which gives excellent agreement with the experimental data for velocity on the Fermi level equal to vf ≈ 0.85×106 m/s. That characterized strained Hg1-x CdxTe layers (0.13 < x < 0.14) are a perfect Topological Insulator with good perspectives of further applications.

Reduction of U3O8 to U by a metallic reductant, Li

International Nuclear Information System (INIS)

Jin-Mok Hur; Sun-Seok Hong; Hansoo Lee

2010-01-01

Reduction of U 3 O 8 was investigated for the recycling of spent oxide fuel from a commercial nuclear power plant. The possible reduction methods were proposed and compared. Based on the thermodynamic analysis, Li metal was selected as a reductant. The optimum reaction temperature for the reduction of U 3 O 8 was investigated at the wider reaction temperature range. The adverse oxidation of U metal by Li 2 O at 1,000 deg C was experimentally verified. Ellingham diagram was constructed to investigate the extent of the uranium oxides reduction when the reaction was carried out above melting point of U metal. (author)

U and Th background contents in the Crimea rocks, Th/U ratio interpretation

International Nuclear Information System (INIS)

Gerasimov, Yu.G.; Voronova, M.A.; AN Ukrainskoj SSR, Kiev. Inst. Geologicheskikh Nauk)

1981-01-01

Radiogeochemical sampling of rocks in the Crimea is carried out. Analyses for U are made by luminescence method, while for Th by X-ray one. About 1000 samples, characterizing the whole stratigraphical cross section except Pz of crystalline rocks, have been analyzed. Low background values for U and Th are established; U content of 1.3-2.3 g/kg and Th content of 7.0-9.0 g/kg are predominant, that is lower than the clark of the earth crust. The distribution of radioelements in stepper and submontane Crimea is gradual, while in mountain part - the mosaic one. Results of Th/U ratios interpretation are presented [ru

Extreme fractionation of 234U 238U and 230Th 234U in spring waters, sediments, and fossils at the Pomme de Terre Valley, southwestern Missouri

Science.gov (United States)

Szabo, B. J.

1982-01-01

Isotopic fractionation as great as 1600% exists between 234U and 238U in spring waters, sediments, and fossils in the Pomme de Terre Valley, southwestern Missouri. The activity ratios of 234U 238U in five springs range from 7.2 to 16 in water which has been discharged for at least the past 30,000 years. The anomalies in 234U 238U ratio in deep water have potential usefulness in hydrologic investigations in southern Missouri. Clayey units overlying the spring bog sediments of Trolinger Spring are enriched in 230Th relative to their parent 234U by as much as 720%. The results indicate that both preferential displacement via alpha recoil ejection and the preferential emplacement via recoiling and physical entrapment are significant processes that are occurring in the geologic environment. ?? 1982.

U Ananth Kini

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. U Ananth Kini. Articles written in Resonance – Journal of Science Education. Volume 6 Issue 12 December 2001 pp 69-79 General Article. Peer-to-Peer Networking - Is this the Future of Network Computing? U Ananth Kini Samarth M Shetty · More Details Fulltext ...

A U Ubale

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A U Ubale. Articles written in Bulletin of Materials Science. Volume 28 Issue 1 February 2005 pp 43-47 Thin Films. Preparation and study of thickness dependent electrical characteristics of zinc sulfide thin films · A U Ubale D K Kulkarni · More Details Abstract Fulltext PDF.

Progress on FIR interferometry and Thomson Scattering measurements on HIT-SI3

Science.gov (United States)

Everson, Christopher; Jarboe, Thomas; Morgan, Kyle

2017-10-01

Spatially resolved measurements of the electron temperature (Te) and density (ne) will be fundamental in assessing the degree to which HIT-SI3 demonstrates closed magnetic flux and energy confinement. Further, electron temperature measurements have not yet been made on an inductively-driven spheromak. Far infrared (FIR) interferometer and Thomson Scattering (TS) systems have been installed on the HIT-SI3 spheromak. The TS system currently implemented on HIT-SI3 was originally designed for other magnetic confinement experiments, and progress continues toward modifying and optimizing for HIT-SI3 plasmas. Initial results suggest that the electron temperature is of order 10 eV. Plans to modify the TS system to provide more sensitivity and accuracy at low temperatures are presented. The line-integrated ne is measured on one chord by the FIR interferometer, with densities near 5x1019 m-3. Four cylindrical volumes have been added to the HIT-SI3 apparatus to enhance passive pumping. It is hoped that this will allow for more control of the density during the 2 ms discharges. Density measurements from before and after the installation of the passive pumping volumes are presented for comparison.

Observations and modeling of magnetized plasma jets and bubbles launched into a transverse B-field

Science.gov (United States)

Fisher, Dustin M.; Zhang, Yue; Wallace, Ben; Gilmore, Mark; Manchester, Ward B., IV; van der Holst, Bart; Rogers, Barrett N.; Hsu, Scott C.

2017-10-01

Hot, dense, plasma structures launched from a coaxial plasma gun on the HelCat dual-source plasma device at the University of New Mexico drag frozen-in magnetic flux into the chamber's background magnetic field providing a rich set of dynamics to study magnetic turbulence, force-free magnetic spheromaks, shocks, as well as CME-like dynamics possibly relevant to the solar corona. Vector magnetic field data from an eleven-tipped B-dot rake probe and images from an ultra-fast camera will be presented in comparison with ongoing MHD modeling using the 3-D MHD BATS-R-US code developed at the University of Michigan. BATS-R-US employs an adaptive mesh refinement grid (AMR) that enables the capture and resolution of shock structures and current sheets and is uniquely suited for flux-rope expansion modeling. Recent experiments show a possible magnetic Rayleigh-Taylor (MRT) instability that appears asymmetrically at the interface between launched spheromaks (bubbles) and their entraining background magnetic field. Efforts to understand this instability using in situ measurements, new chamber boundary conditions, and ultra-fast camera data will be presented. Work supported by the Army Research Office Award No. W911NF1510480.

Numerical Study of Field-reversed Configurations: The Formation and Ion Spin-up

International Nuclear Information System (INIS)

Belova, E.V.; Davidson, R.C.; Ji, H.; Yamada, M.; Cothran, C.D.; Brown, M.R.; Schaffer, M.J.

2005-01-01

Results of three-dimensional numerical simulations of field-reversed configurations (FRCs) are presented. Emphasis of this work is on the nonlinear evolution of magnetohydrodynamic (MHD) instabilities in kinetic FRCs, and the new FRC formation method by counter-helicity spheromak merging. Kinetic simulations show nonlinear saturation of the n = 1 tilt mode, where n is the toroidal mode number. The n = 2 and n = 3 rotational modes are observed to grow during the nonlinear phase of the tilt instability due to the ion spin-up in the toroidal direction. The ion toroidal spin-up is shown to be related to the resistive decay of the internal flux, and the resulting loss of particle confinement. Three-dimensional MHD simulations of counter-helicity spheromak merging and FRC formation show good qualitative agreement with results from the SSX-FRC experiment. The simulations show formation of an FRC in about 20-30 Alfven times for typical experimental parameters. The growth rate of the n = 1 tilt mode is shown to be significantly reduced compared to the MHD growth rate due to the large plasma viscosity and field-line-tying effects

Izvršilne funkcije pri učencih s primanjkljaji na posameznih področjih učenja

OpenAIRE

Senekovič, Jasna

2017-01-01

V magistrskem delu z naslovom Izvršilne funkcije pri učencih s primanjkljaji na posameznih področjih učenja v prvem delu predstavljamo dosedanja spoznanja o izvršilnih funkcijah in učnih težavah v osnovni šoli, še posebej učencev s primanjkljaji na posameznih področjih učenja (PPPU). Tako smo v teoretičnem delu najprej opredelili osnovne pojme izvršilne funkcije, samoregulacija, metakognicija, učenje učenja in učne težave, posebej še primanjkljaje na posameznih področjih učenja. Podrobneje sm...

Etika u poduzetništvu

OpenAIRE

Ivančir, Monika

2018-01-01

Ovim diplomskim radom ukazuje se na problematiku današnjice glede poslovne etike. Naglasak se stavlja na etiku u poduzetništvu. Istaknuti su najčešći moralni problemi s kojima se susreću današnji poduzetnici i želi se naglasiti važnost etike u svim poslovnim odnosima i odlukama. Zadaća svakog poduzetnika, koji se želi voditi načelima etike, jest da uspostavi ravnotežu između ekonomske i društveno odgovorne strane poslovanja. Samo na taj način, na današnjem promjenjivom tržištu, poduzetnik...

Edward U Lorenz

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Edward U Lorenz. Articles written in Resonance – Journal of Science Education. Volume 20 Issue 3 March 2015 pp 260-263 Classics. Predictability: Does the Flap of a Butterfly's Wings in Brazil Set off a Tornado in Texas? Edward U Lorenz · More Details Fulltext ...

Photoluminescence from CdxHg1-xTe

International Nuclear Information System (INIS)

Breivik, M; Selvig, E; Tonheim, C R; Brendhagen, E; Brudevoll, T; Rheenen, A D van; Steen, H; Nicolas, S; Lorentzen, T; Haakenaasen, R

2008-01-01

We present important aspects of photoluminescence (PL) of Cd x Hg 1-x Te in the infrared part of the spectrum where background thermal radiation significantly affects the PL spectrum. We show how the background spectrum can be removed from the data. We also show how the wavelength of the excitation laser affects the relative intensity of the PL peaks from a multi-layer structure. Finally, we present temperature dependent PL of a Cd 0.36 Hg 0.64 Te/Cd 0.61 Hg 0.39 Te multiple quantum well structure grown on a 4 μm thick Cd 0.36 Hg 0.64 Te buffer layer. We attribute the low temperature peak from the buffer layer to impurities. The impurity levels are depopulated as the temperature increases, resulting in a decreased PL peak intensity. Above ∼200 K a band-to-band peak from the buffer layer is observed. The quantum well peak persists up to ∼200 K

The inflow of 234U and 238U from the River Odra drainage basin to the Baltic Sea

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Bogdan Skwarzec

2010-12-01

Full Text Available In this study the activity of uranium isotopes 234U and 238U in Odra river water samples, collected from October 2003 to July2004, was measured using alpha spectrometry. The uranium concentrations were different in each of the seasons analysed; the lowest values were recorded in summer. In all seasons, uranium concentrations were the highest in Bystrzyca river waters (from 27.81 ± 0.29Bq m-3 of 234U and 17.82 ± 0.23 Bq m-3 of 238U in spring to 194.76 ± 3.43 Bq m-3 of 234U and 134.88 ± 2.85 Bq m-3 of 238U in summer. The lowest concentrations were noted in the Mała Panew (from 1.33 ± 0.02 Bq m-3 of 234U and 1.06 ± 0.02 Bq m-3 of 238U in spring to 3.52 ± 0.05 Bq m-3 of 234U and 2.59± 0.04 Bq m-3 of 238U in autumn. The uranium radionuclides 234U and 238U in the water samples were not in radioactive equilibrium. The 234U / 238U activity ratios were the highest in Odra water samples collected at Głogów (1.84 in autumn, and the lowest in water from the Noteć (1.03 in winter and spring. The 234U / 238U activity ratio decreases along the main stream of the Odra, owing to changes in the salinity of the river's waters. Annually, 8.19 tons of uranium (126.29 G Bq of 234U and 100.80 G Bq of 238U flow into the Szczecin Lagoon with Odra river waters.

Joint U. S. --U. S. S. R. test of U. S. MHD electrode systems in U. S. S. R. U-02 MHD facility (phase I). Final report

Energy Technology Data Exchange (ETDEWEB)

Hosler, W R [ed.

1976-01-01

The first (Phase I) joint U.S.-U.S.S.R. test of U.S. electrode materials was carried out in Moscow between September 25 and October 8, 1975 in the Soviet U-02 MHD facility. The test procedure followed closely a predetermined work plan designed to test five different zirconia based materials and the cathode and anode electrode wall modules under MHD operating conditions. The materials which were selected were 88Zr0/sub 2/-12Y/sub 2/0/sub 3/, 82Zr0/sub 2/-18Ce02, 50Zr0/sub 2/-50Ce0/sub 2/, 25Zr0/sub 2/-75Ce0/sub 2/ and 20Zr0/sub 2/-78Ce0/sub 2/-2Ta/sub 2/0/sub 5/. The electrode modules were constructed by Westinghouse Research and Development Laboratory. Each of the five electrode materials had four different current densities established between the anode and cathode during the experiment which lasted a total of 127 hours. There were four main phases in the test schedule: (1) start-up of the channel over a specific heating period. No seed (K/sub 2/C0/sub 3/) introduction - 18 hours. (2) Electrical tests at operating temperature to investigate electro-physical characteristics of the channel and electrodes - 6 hours. (3) Operating life test - 94 hours. (4) Shut-down of the channel over a specific cool down period - 9 hours. All except six electrode pairs performed satisfactorily during the entire test. These were the pairs which were designated to carry maximum or near maximum current density. Five pairs failed early in the life test and the sixth pair failed in the last several hours. Failure was not due to the electrode materials, however, but due to lead-out melting caused by joule heating in the platinum wires. The U-02 facility is described and the operational parameters are given for each phase of the test. The electrode and insulating walls are described and the appropriate parameters that are used to predict the performance of the module are given.

G U Kulkarni

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. G U Kulkarni. Articles written in Bulletin of Materials Science. Volume 24 Issue 5 October 2001 pp 515-521 Magnetic Materials. Submicron particles of Co, Ni and Co–Ni alloys · P Saravanan T A Jose P John Thomas G U Kulkarni · More Details Abstract Fulltext PDF. Magnetic ...

U.V.-enhanced reactivation of u.v.-irradiated herpes virus by primary cultures of rat hepatocytes

International Nuclear Information System (INIS)

Zurlo, J.; Yager, J.D.

1984-01-01

Carcinogen treatment of cultured mammalian cells prior to infection with u.v.-irradiated virus results in enhanced virus survival and mutagenesis suggesting the induction of SOS-type processes. In this paper, we report the development of a primary rat hepatocyte culture system to investigate cellular responses to DNA damage which may be relevant to hepatocarcinogenesis in vivo. We have obtained data demonstrating that enhanced reactivation of u.v.-irradiated Herpes simplex virus type 1 (HSV-1) occurs in hepatocytes irradiated with u.v. Cultured hepatocytes were pretreated with u.v. at the time of enhanced DNA synthesis. These treatments caused an inhibition followed by a recovery of DNA synthesis. At various times after pretreatment, the hepatocytes were infected with control or u.v.-irradiated HSV-1 at low multiplicity, and virus survival was measured by direct plaque assay. U.v.-irradiated HSV-1 exhibited the expected two-component survival curve in control or u.v. pretreated hepatocytes. The magnitude of enhanced reactivation of HSV-1 was dependent on the u.v. dose to the hepatocytes, the time of infection following u.v. pretreatment, and the level of DNA synthesis at the time of pretreatment. These results suggest that u.v. treatment of rat hepatocytes causes the induction of SOS-type functions that may have a role in the initiation of hepatocarcinogenesis

Uniqueness of Positive Solutions of Δu+f(u)=0 in N, N<=3

Science.gov (United States)

Cortázar, Carmen; Elgueta, Manuel; Felmer, Patricio

We study the uniqueness of radial ground states for the semilinear elliptic partial differential equation $Δ u+f(u)=0 {(*)}$ in N. We assume that the function f has two zeros, the origin and u0>0. Above u0 the function f is positive, is locally Lipschitz continuous and satisfies convexity and growth conditions of a superlinear nature. Below u0, f is assumed to be non-positive, non-identically zero and merely continuous. Our results are obtained through a careful analysis of the solutions of an associated initial-value problem, and the use of a monotone separation theorem. It is known that, for a large class of functions f, the ground states of (*) are radially symmetric. In these cases our result implies that (*) possesses at most one ground state.

Nizozemska bolest u Bolivarijanskoj Republici Venezueli

OpenAIRE

Jošić, Doc. dr. sc. Hrvoje; Maček Pandak, Fran

2017-01-01

Venezuela je od svog osamostaljenja gospodarstvo temeljila na proizvodnji i izvozu jednog proizvoda. U 19. stoljeću to su bili kava i kakaovac koje je u 20. stoljeću zamijenila nafta. Navedeno je dovelo do nizozemske bolesti koja je gušila ostale gospodarske grane, pa su često korumpirane vlasti kupovale socijalni mir socijalističkim politikama i državnom potrošnjom. 1980-ih došlo je do prvog značajnijeg pada cijene nafte u 20. stoljeću te je Venezuela morala provesti liberalne reforme kako b...

The fission cross sections of /sup 230/Th, /sup 232/Th, /sup 233/U, /sup 234/U, /sup 236/U, /sup 238/U, /sup 237/Np, /sup 239/Pu and /sup 242/Pu relative /sup 235/U at 14. 74 MeV neutron energy

Energy Technology Data Exchange (ETDEWEB)

Meadows, J.W.

1986-12-01

The measurement of the fission cross section ratios of nine isotopes relative to /sup 235/U at an average neutron energy of 14.74 MeV is described with particular attention to the determination of corrections and to sources of error. The results are compared to ENDF/B-V and to other measurements of the past decade. The ratio of the neutron induced fission cross section for these isotopes to the fission cross section for /sup 235/U are: /sup 230/Th - 0.290 +- 1.9%; /sup 232/Th - 0.191 +- 1.9%; /sup 233/U - 1.132 +- 0.7%; /sup 234/U - 0.998 +- 1.0%; /sup 236/U - 0.791 +- 1.1%; /sup 238/U - 0.587 +- 1.1%; /sup 237/Np - 1.060 +- 1.4%; /sup 239/Pu - 1.152 +- 1.1%; /sup 242/Pu - 0.967 +- 1.0%. 40 refs., 11 tabs., 9 figs.

77 FR 42727 - Environmental Impacts Statements; Notice of Availability

Science.gov (United States)

2012-07-20

...: https://cdx.epa.gov . EIS No. 20120230, Draft EIS, USACE, CA, Sierra Vista Specific Plan Development... No. 20120232, Final EIS, RUS, MN, Hampton--Rochester--La Crosse Transmission System Improvement... Hampton, MN and La Crosse, WI, Review Period Ends: 08/20/2012, Contact: Stephanie A. Strength 202-720-0820...

78 FR 23927 - Forms and Procedures for Submitting Attest Engagements Under Various Subparts

Science.gov (United States)

2013-04-23

... attest engagement procedures described in this notice are effective starting with attest engagements due... documents and provide a secure environment for data exchange. Among the advantages offered by CDX are the... claimed as confidential business information by the submitter), but the data must be made available to EPA...

Thermoelectric material comprising scandium doped zinc cadmium oxide

DEFF Research Database (Denmark)

2016-01-01

There is presented a composition of scandium doped Zinc Cadmium Oxide with the general formula ZnzCdxScyO which the inventors have prepared, and for which material the inventors have made the insight that it is particularly advantageous as an n-type oxide material, such as particularly advantageous...

Preparation of D-[U-14C]galactose and α-D-[U-14C]galactose-1-phosphate

International Nuclear Information System (INIS)

Kolina, J.; Hromadkova, B.

1989-01-01

Optically pure D-[U- 14 C]galactose was prepared on a preparatory scale using the galactokinase enzyme. The suggested procedure allows to also prepare a α-D-[U- 14 C]galactose-1-phosphate and L-[U- 14 ]galactose giving good yield. The experiments proved that the raw fraction isolated from yeast of the Kluyveromyces fragilis strain or the Kluyveromyces lactis strain shows sufficient activity. Phosphorylation of D-[U- 14 C]galactose practically terminates after 30 mins of incubation. DL-[U- 14 C]galactose isolated using preparatory paper chromatography from the acid hydrolyzate of [U- 14 C] polysaccharide is a satisfactory radioactive precursor. The developed preparation procedure theoretically contributed towards the further elucidation of the problem of the proportional representation of galactose stereo-isomers in extracellular polysaccharide isolated from red algae. In this respect data in the literature differ and some sources state a significantly higher propertion of L-galactose. The experiments showed that [U- 14 C] polysaccharide isolated from the red algae Porphyridium cruentum prevalently contains D-[U- 14 C]galactose, which confirms the process of enzyme reaction. (author). 1 tab., 4 refs

Kinetics and mechanism of photoaccelerated isotope exchange between U(VI) and U(IV) in oxalate solutions

International Nuclear Information System (INIS)

Shaban, I.S.; Owreit, M.F.; Nikitenko, S.I.

1992-01-01

A kinetic study of thermal and photoaccelerated U(IV)-U(VI) isotope exchange has been carried out in oxalate solutions at 11-40 deg C. The rate and quantum yield were determined as a function of U(IV), U(VI) and oxalate concentration, wavelength of incident light, temperature and absorbed dose of γ-radiation. The kinetic equations for thermal and photoaccelerated exchange have been obtained. It was assumed that the mechanism of exchange involves formation of U(V) as an intermediate, followed by slow exchange between U(V) and U(IV). The isokinetic dependence confirms the identity of limiting stages for thermal and photostimulated exchange. The upper component of photoexcited T 1 level of uranyl is supposed to be the most reactive in the process of U(V) generation. It was observed that the small doses of γ-radiation evoke the acceleration of isotope exchange, however, at D>100 krad the rate of exchange is reduced to the level of thermal exchange. (author) 8 refs.; 4 figs.; 2 tabs

OSNOVNA PODRUČJA PRIMJENE MARKETINGA U FINANCIJSKIM INSTITUCIJAMA U TRANZICIJSKIM I NEDOVOLJNO RAZVIJENIM ZEMLJAMA

OpenAIRE

Tomašević Lišanin, Marija; Pavičić, Jurica; Renko, Fran

2000-01-01

Autori ovog članka smatraju da se efikasan marketing u financijskim institucijama u tranzicijskim i u nedovoljno razvijenim zemljama mora usmjeravati na rješavanje triju osnovnih marketinških problema tih institucija: na izgradnju povjerenja, na informiranje i na izgradnju kvalitetnih dugoročnih odnosa s komitentima, pa su stoga tome problemu posvetili posebnu pažnju.

Fission Product Yields of 233U, 235U, 238U and 239Pu in Fields of Thermal Neutrons, Fission Neutrons and 14.7-MeV Neutrons

Science.gov (United States)

Laurec, J.; Adam, A.; de Bruyne, T.; Bauge, E.; Granier, T.; Aupiais, J.; Bersillon, O.; Le Petit, G.; Authier, N.; Casoli, P.

2010-12-01

The yields of more than fifteen fission products have been carefully measured using radiochemical techniques, for 235U(n,f), 239Pu(n,f) in a thermal spectrum, for 233U(n,f), 235U(n,f), and 239Pu(n,f) reactions in a fission neutron spectrum, and for 233U(n,f), 235U(n,f), 238U(n,f), and 239Pu(n,f) for 14.7 MeV monoenergetic neutrons. Irradiations were performed at the EL3 reactor, at the Caliban and Prospero critical assemblies, and at the Lancelot electrostatic accelerator in CEA-Valduc. Fissions were counted in thin deposits using fission ionization chambers. The number of fission products of each species were measured by gamma spectrometry of co-located thick deposits.

KONJOGOJSTVO U REPUBLICI HRVATSKOJ - STANJE I PERSPEKTIVA

OpenAIRE

Baban, Mirjana; Gregić, Maja; Korabi, Nidal; Antunović, Boris

2013-01-01

Ulaskom Republike Hrvatske u Europsku uniju u posljednjih nekoliko godina implementiraju se prilagodbe koje će osigurati usklađivanje konjogojstva s važećim europskim propisima. Unatoč globalnoj ekonomskoj krizi i u sektoru konjogojstva, ukupan broj konja se u Hrvatskoj kontinuirano povećava i nastavljaju se pozitivni trendovi u uzgoju. No, iako postoji uzlazni trend, posljedice recesije zasigurno će ostaviti traga i na brojnom stanju konja u Hrvatskoj. U posljednjem desetljeću broj konja pod...

Association of vitamin D receptor gene polymorphisms with polycystic ovary syndrome among Indian women

Science.gov (United States)

Dasgupta, Shilpi; Dutta, Joyita; Annamaneni, Sandhya; Kudugunti, Neelaveni; Battini, Mohan Reddy

2015-01-01

Background & objectives: The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS). Studies on VDR polymorphisms among PCOS women are sparse. We undertook this study to investigate the association pattern of VDR polymorphisms (Cdx2, Fok1, Apa1 and Taq1) with PCOS among Indian women. Methods: For the present study, 250 women with PCOS and 250 normal healthy control women were selected from Hyderabad city, Telangana, India. The four VDR polymorphisms were genotyped and analysed using ASM-PCR (allele specific multiple PCR) and PCR-RFLP (restriction fragment length polymorphism). Results: The genotype and allele frequency distributions of only Cdx2 showed significant difference between the PCOS cases and control women, indicating protective role of this SNP against PCOS phenotype. However, significant association was observed between VDR genotypes and some of the PCOS specific clinical/biochemical traits. For example, Fok1 showed a significant genotypic difference for the presence of infertility and Cdx2 genotpes showed association with testosterone levels. Further, the two haplotypes, ACCA and ACTA, were found to be significantly associated with PCOS indicating haplotype specific risk. Interpretation & conclusions: Although VDR polymorphisms have not shown significant association with PCOS, in view of functional significance of the SNPs considered, one cannot yet rule out the possibility of their association with PCOS. Further, specifically designed studies on large cohorts are required to conclusively establish the role of VDR polymorphisms in PCOS, particularly including data on vitamin D levels. PMID:26458343

Association of vitamin D receptor gene polymorphisms with polycystic ovary syndrome among Indian women

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Shilpi Dasgupta