Canonical correlation analysis of professional stress,social support,and professional burnout among low-rank army officers

Directory of Open Access Journals (Sweden)

Chuan-yun LI

2011-12-01

Full Text Available Objective The present study investigates the influence of professional stress and social support on professional burnout among low-rank army officers.Methods The professional stress,social support,and professional burnout scales among low-rank army officers were used as test tools.Moreover,the officers of established units(battalion,company,and platoon were chosen as test subjects.Out of the 260 scales sent,226 effective scales were received.The descriptive statistic and canonical correlation analysis models were used to analyze the influence of each variable.Results The scores of low-rank army officers in the professional stress,social support,and professional burnout scales were more than average,except on two factors,namely,interpersonal support and de-individualization.The canonical analysis identified three groups of canonical correlation factors,of which two were up to a significant level(P < 0.001.After further eliminating the social support variable,the canonical correlation analysis of professional stress and burnout showed that the canonical correlation coefficients P corresponding to 1 and 2 were 0.62 and 0.36,respectively,and were up to a very significant level(P < 0.001.Conclusion The low-rank army officers experience higher professional stress and burnout levels,showing a lower sense of accomplishment,emotional exhaustion,and more serious depersonalization.However,social support can reduce the onset and seriousness of professional burnout among these officers by lessening pressure factors,such as career development,work features,salary conditions,and other personal factors.

Canonical correlation analysis of synchronous neural interactions and cognitive deficits in Alzheimer's dementia

Science.gov (United States)

Karageorgiou, Elissaios; Lewis, Scott M.; Riley McCarten, J.; Leuthold, Arthur C.; Hemmy, Laura S.; McPherson, Susan E.; Rottunda, Susan J.; Rubins, David M.; Georgopoulos, Apostolos P.

2012-10-01

In previous work (Georgopoulos et al 2007 J. Neural Eng. 4 349-55) we reported on the use of magnetoencephalographic (MEG) synchronous neural interactions (SNI) as a functional biomarker in Alzheimer's dementia (AD) diagnosis. Here we report on the application of canonical correlation analysis to investigate the relations between SNI and cognitive neuropsychological (NP) domains in AD patients. First, we performed individual correlations between each SNI and each NP, which provided an initial link between SNI and specific cognitive tests. Next, we performed factor analysis on each set, followed by a canonical correlation analysis between the derived SNI and NP factors. This last analysis optimally associated the entire MEG signal with cognitive function. The results revealed that SNI as a whole were mostly associated with memory and language, and, slightly less, executive function, processing speed and visuospatial abilities, thus differentiating functions subserved by the frontoparietal and the temporal cortices. These findings provide a direct interpretation of the information carried by the SNI and set the basis for identifying specific neural disease phenotypes according to cognitive deficits.

DNA pattern recognition using canonical correlation algorithm.

Science.gov (United States)

Sarkar, B K; Chakraborty, Chiranjib

2015-10-01

We performed canonical correlation analysis as an unsupervised statistical tool to describe related views of the same semantic object for identifying patterns. A pattern recognition technique based on canonical correlation analysis (CCA) was proposed for finding required genetic code in the DNA sequence. Two related but different objects were considered: one was a particular pattern, and other was test DNA sequence. CCA found correlations between two observations of the same semantic pattern and test sequence. It is concluded that the relationship possesses maximum value in the position where the pattern exists. As a case study, the potential of CCA was demonstrated on the sequence found from HIV-1 preferred integration sites. The subsequences on the left and right flanking from the integration site were considered as the two views, and statistically significant relationships were established between these two views to elucidate the viral preference as an important factor for the correlation.

Scalable and Flexible Multiview MAX-VAR Canonical Correlation Analysis

Science.gov (United States)

Fu, Xiao; Huang, Kejun; Hong, Mingyi; Sidiropoulos, Nicholas D.; So, Anthony Man-Cho

2017-08-01

Generalized canonical correlation analysis (GCCA) aims at finding latent low-dimensional common structure from multiple views (feature vectors in different domains) of the same entities. Unlike principal component analysis (PCA) that handles a single view, (G)CCA is able to integrate information from different feature spaces. Here we focus on MAX-VAR GCCA, a popular formulation which has recently gained renewed interest in multilingual processing and speech modeling. The classic MAX-VAR GCCA problem can be solved optimally via eigen-decomposition of a matrix that compounds the (whitened) correlation matrices of the views; but this solution has serious scalability issues, and is not directly amenable to incorporating pertinent structural constraints such as non-negativity and sparsity on the canonical components. We posit regularized MAX-VAR GCCA as a non-convex optimization problem and propose an alternating optimization (AO)-based algorithm to handle it. Our algorithm alternates between {\\em inexact} solutions of a regularized least squares subproblem and a manifold-constrained non-convex subproblem, thereby achieving substantial memory and computational savings. An important benefit of our design is that it can easily handle structure-promoting regularization. We show that the algorithm globally converges to a critical point at a sublinear rate, and approaches a global optimal solution at a linear rate when no regularization is considered. Judiciously designed simulations and large-scale word embedding tasks are employed to showcase the effectiveness of the proposed algorithm.

Canonical correlation between the gamma and X-ray data of Swift GRBs

International Nuclear Information System (INIS)

Balazs, L. G.; Horvath, I.; Meszaros, P.; Tusnady, G.; Veres, P.

2009-01-01

We used the canonical correlation analysis of the multivariate statistics to study the interrelation between the gamma (Fluence, 1 sec Peakflux, duration) and X-ray (early X flux, 24 hours X flux, X decay index, X spectral index, X HI column density) data. We computed the canonical correlations and variables showing that there is a significant interrelation between the gamma and X-ray data. Using the canonical variables resulted in the analysis we computed their correlations (canonical loadings) with the original ones. The canonical loadings revealed that the gamma-ray fluence and the early X-ray flux give the strongest contribution to the correlation in contrast to the X-ray decay index and spectral index. An interesting new result appears to be the strong contribution of the HI column density to the correlation. Accepting the collapsar model of long GRBs this effect may be interpreted as an indication for the ejection of an HI envelope by the progenitor in the course of producing the GRB.

Generalized canonical correlation analysis of matrices with missing rows : A simulation study

NARCIS (Netherlands)

van de Velden, Michel; Bijmolt, Tammo H. A.

A method is presented for generalized canonical correlation analysis of two or more matrices with missing rows. The method is a combination of Carroll's (1968) method and the missing data approach of the OVERALS technique (Van der Burg, 1988). In a simulation study we assess the performance of the

Climate Prediction Center (CPC)Ensemble Canonical Correlation Analysis 90-Day Seasonal Forecast of Precipitation

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Ensemble Canonical Correlation Analysis (ECCA) precipitation forecast is a 90-day (seasonal) outlook of US surface precipitation anomalies. The ECCA uses...

Group sparse canonical correlation analysis for genomic data integration.

Science.gov (United States)

Lin, Dongdong; Zhang, Jigang; Li, Jingyao; Calhoun, Vince D; Deng, Hong-Wen; Wang, Yu-Ping

2013-08-12

The emergence of high-throughput genomic datasets from different sources and platforms (e.g., gene expression, single nucleotide polymorphisms (SNP), and copy number variation (CNV)) has greatly enhanced our understandings of the interplay of these genomic factors as well as their influences on the complex diseases. It is challenging to explore the relationship between these different types of genomic data sets. In this paper, we focus on a multivariate statistical method, canonical correlation analysis (CCA) method for this problem. Conventional CCA method does not work effectively if the number of data samples is significantly less than that of biomarkers, which is a typical case for genomic data (e.g., SNPs). Sparse CCA (sCCA) methods were introduced to overcome such difficulty, mostly using penalizations with l-1 norm (CCA-l1) or the combination of l-1and l-2 norm (CCA-elastic net). However, they overlook the structural or group effect within genomic data in the analysis, which often exist and are important (e.g., SNPs spanning a gene interact and work together as a group). We propose a new group sparse CCA method (CCA-sparse group) along with an effective numerical algorithm to study the mutual relationship between two different types of genomic data (i.e., SNP and gene expression). We then extend the model to a more general formulation that can include the existing sCCA models. We apply the model to feature/variable selection from two data sets and compare our group sparse CCA method with existing sCCA methods on both simulation and two real datasets (human gliomas data and NCI60 data). We use a graphical representation of the samples with a pair of canonical variates to demonstrate the discriminating characteristic of the selected features. Pathway analysis is further performed for biological interpretation of those features. The CCA-sparse group method incorporates group effects of features into the correlation analysis while performs individual feature

Structured sparse canonical correlation analysis for brain imaging genetics: an improved GraphNet method.

Science.gov (United States)

Du, Lei; Huang, Heng; Yan, Jingwen; Kim, Sungeun; Risacher, Shannon L; Inlow, Mark; Moore, Jason H; Saykin, Andrew J; Shen, Li

2016-05-15

Structured sparse canonical correlation analysis (SCCA) models have been used to identify imaging genetic associations. These models either use group lasso or graph-guided fused lasso to conduct feature selection and feature grouping simultaneously. The group lasso based methods require prior knowledge to define the groups, which limits the capability when prior knowledge is incomplete or unavailable. The graph-guided methods overcome this drawback by using the sample correlation to define the constraint. However, they are sensitive to the sign of the sample correlation, which could introduce undesirable bias if the sign is wrongly estimated. We introduce a novel SCCA model with a new penalty, and develop an efficient optimization algorithm. Our method has a strong upper bound for the grouping effect for both positively and negatively correlated features. We show that our method performs better than or equally to three competing SCCA models on both synthetic and real data. In particular, our method identifies stronger canonical correlations and better canonical loading patterns, showing its promise for revealing interesting imaging genetic associations. The Matlab code and sample data are freely available at http://www.iu.edu/∼shenlab/tools/angscca/ shenli@iu.edu Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Canonical correlation analysis of the career attitudes and strategies inventory and the adult career concerns inventory

Directory of Open Access Journals (Sweden)

Charlene C Lew

2006-04-01

Full Text Available This study investigated the relationships between the scales of the Adult Career Concerns Inventory (ACCI and those of the Career Attitudes and Strategies Inventory (CASI. The scores of 202 South African adults for the two inventories were subjected to a canonical correlation analysis. Two canonical variates made statistically significant contributions to the explanation of the relationships between the two sets of variables. Inspection of the correlations of the original variables with the first canonical variate suggested that a high level of career concerns in general, as measured by the ACCI, is associated with high levels of career worries, more geographical barriers, a low risk-taking style and a non-dominant interpersonal style, as measured by the CASI. The second canonical variate suggested that concerns with career exploration and advancement of one’s career is associated with low job satisfaction, low family commitment, high work involvement, and a dominant style at work.

CANONICAL CORRELATION OF MORPHOLOGIC CHARACTERISTIC AND MOTORIC ABILITIES OF YOUNG JUDO ATHLETES

Directory of Open Access Journals (Sweden)

Lulzim Ibri

2013-07-01

Full Text Available In sample from 80 young judo athletes aged from 16-17 year, was applied the system a total of 18 variables, of which 10 are morphologic characteristic and 8 motoric abilities variables, with a purpose to determinate mutual report between each other, while the information were analyzed by using canonical correlation analysis. With case of authentication statistically important relation was achieve one pair of canonical correlations statistically important. In morphologic variables field the canonical factor is interpreted in first canonical structure is the consists of variables: adipose tissue under skin of stomach (ATST, adipose tissue under skin of triceps (ATTR, adipose tissue under skin of biceps (ATBI, adipose tissue under skin of sub scapulars (ATSS, adipose tissue under skin of sub iliac a (ATSI and adipose tissue under skin of list (ATSL, so that is interpreted as a canonical factor of adipose tissue: And second structure of canonical factors of anthropometric characteristics is the consists of variables: body length: body length (LEBO, length of the leg (LELE and length of the arm (LEAR, so that is interpreted as a canonical factor of longitudinal dimensionality. The first structure of canonical factors in motoric variables is can not be interpreted because of low values of motor variables, while second structure of canonical factors of motoric abilities is the consists of variables: squeeze palm (SQPA, so that is interpreted as a canonical factor of strong factor in palm. Based on structure analysis of matrix results of canonical factors results were shown that to young judo athletes of this age exist statistically valid correlations between canonical factor of anthropometric variables and canonical factor of variables to motoric abilities which is (Rc=77 that is statistically valid in level (P=00.

Non-linear canonical correlation for joint analysis of MEG signals from two subjects

Directory of Open Access Journals (Sweden)

Cristina eCampi

2013-06-01

Full Text Available We consider the problem of analysing magnetoencephalography (MEG data measured from two persons undergoing the same experiment, and we propose a method that searches for sources with maximally correlated energies. Our method is based on canonical correlation analysis (CCA, which provides linear transformations, one for each subject, such that the correlation between the transformed MEG signals is maximized. Here, we present a nonlinear version of CCA which measures the correlation of energies. Furthermore, we introduce a delay parameter in the modelto analyse, e.g., leader-follower changes in experiments where the two subjects are engaged in social interaction.

Pyrcca: regularized kernel canonical correlation analysis in Python and its applications to neuroimaging

OpenAIRE

Natalia Y Bilenko; Jack L Gallant; Jack L Gallant

2016-01-01

In this article we introduce Pyrcca, an open-source Python package for performing canonical correlation analysis (CCA). CCA is a multivariate analysis method for identifying relationships between sets of variables. Pyrcca supports CCA with or without regularization, and with or without linear, polynomial, or Gaussian kernelization. We first use an abstract example to describe Pyrcca functionality. We then demonstrate how Pyrcca can be used to analyze neuroimaging data. Specifically, we use Py...

DNA pattern recognition using canonical correlation algorithm

Indian Academy of Sciences (India)

2015-09-28

Sep 28, 2015 ... were considered as the two views, and statistically significant relationships were established between these two ... Canonical correlation analysis is to find two sets of basis ..... Jing XY, Li S, Lan C, Zhang D, Yang JY and Liu Q 2011 Color ... Yu S, Yu K, Tresp V and Kriegel HP 2006 Multi-output regularized.

Registration of prone and supine CT colonography scans using correlation optimized warping and canonical correlation analysis

International Nuclear Information System (INIS)

Wang Shijun; Yao Jianhua; Liu Jiamin; Petrick, Nicholas; Van Uitert, Robert L.; Periaswamy, Senthil; Summers, Ronald M.

2009-01-01

Purpose: In computed tomographic colonography (CTC), a patient will be scanned twice--Once supine and once prone--to improve the sensitivity for polyp detection. To assist radiologists in CTC reading, in this paper we propose an automated method for colon registration from supine and prone CTC scans. Methods: We propose a new colon centerline registration method for prone and supine CTC scans using correlation optimized warping (COW) and canonical correlation analysis (CCA) based on the anatomical structure of the colon. Four anatomical salient points on the colon are first automatically distinguished. Then correlation optimized warping is applied to the segments defined by the anatomical landmarks to improve the global registration based on local correlation of segments. The COW method was modified by embedding canonical correlation analysis to allow multiple features along the colon centerline to be used in our implementation. Results: We tested the COW algorithm on a CTC data set of 39 patients with 39 polyps (19 training and 20 test cases) to verify the effectiveness of the proposed COW registration method. Experimental results on the test set show that the COW method significantly reduces the average estimation error in a polyp location between supine and prone scans by 67.6%, from 46.27±52.97 to 14.98 mm±11.41 mm, compared to the normalized distance along the colon centerline algorithm (p<0.01). Conclusions: The proposed COW algorithm is more accurate for the colon centerline registration compared to the normalized distance along the colon centerline method and the dynamic time warping method. Comparison results showed that the feature combination of z-coordinate and curvature achieved lowest registration error compared to the other feature combinations used by COW. The proposed method is tolerant to centerline errors because anatomical landmarks help prevent the propagation of errors across the entire colon centerline.

Semiotic Analysis of Canon Camera Advertisements

OpenAIRE

INDRAWATI, SUSAN

2015-01-01

Keywords: Semiotic Analysis, Canon Camera, Advertisement. Advertisement is a medium to deliver message to people with the goal to influence the to use certain products. Semiotics is applied to develop a correlation within element used in an advertisement. In this study, the writer chose the Semiotic analysis of canon camera advertisement as the subject to be analyzed using semiotic study based on Peirce's theory. Semiotic approach is employed in interpreting the sign, symbol, icon, and index ...

Personality disorders in substance abusers: Validation of the DIP-Q through principal components factor analysis and canonical correlation analysis

Directory of Open Access Journals (Sweden)

Hesse Morten

2005-05-01

Full Text Available Abstract Background Personality disorders are common in substance abusers. Self-report questionnaires that can aid in the assessment of personality disorders are commonly used in assessment, but are rarely validated. Methods The Danish DIP-Q as a measure of co-morbid personality disorders in substance abusers was validated through principal components factor analysis and canonical correlation analysis. A 4 components structure was constructed based on 238 protocols, representing antagonism, neuroticism, introversion and conscientiousness. The structure was compared with (a a 4-factor solution from the DIP-Q in a sample of Swedish drug and alcohol abusers (N = 133, and (b a consensus 4-components solution based on a meta-analysis of published correlation matrices of dimensional personality disorder scales. Results It was found that the 4-factor model of personality was congruent across the Danish and Swedish samples, and showed good congruence with the consensus model. A canonical correlation analysis was conducted on a subset of the Danish sample with staff ratings of pathology. Three factors that correlated highly between the two variable sets were found. These variables were highly similar to the three first factors from the principal components analysis, antagonism, neuroticism and introversion. Conclusion The findings support the validity of the DIP-Q as a measure of DSM-IV personality disorders in substance abusers.

A learning algorithm for adaptive canonical correlation analysis of several data sets.

Science.gov (United States)

Vía, Javier; Santamaría, Ignacio; Pérez, Jesús

2007-01-01

Canonical correlation analysis (CCA) is a classical tool in statistical analysis to find the projections that maximize the correlation between two data sets. In this work we propose a generalization of CCA to several data sets, which is shown to be equivalent to the classical maximum variance (MAXVAR) generalization proposed by Kettenring. The reformulation of this generalization as a set of coupled least squares regression problems is exploited to develop a neural structure for CCA. In particular, the proposed CCA model is a two layer feedforward neural network with lateral connections in the output layer to achieve the simultaneous extraction of all the CCA eigenvectors through deflation. The CCA neural model is trained using a recursive least squares (RLS) algorithm. Finally, the convergence of the proposed learning rule is proved by means of stochastic approximation techniques and their performance is analyzed through simulations.

Prediction of East African Seasonal Rainfall Using Simplex Canonical Correlation Analysis.

Science.gov (United States)

Ntale, Henry K.; Yew Gan, Thian; Mwale, Davison

2003-06-01

A linear statistical model, canonical correlation analysis (CCA), was driven by the Nelder-Mead simplex optimization algorithm (called CCA-NMS) to predict the standardized seasonal rainfall totals of East Africa at 3-month lead time using SLP and SST anomaly fields of the Indian and Atlantic Oceans combined together by 24 simplex optimized weights, and then `reduced' by the principal component analysis. Applying the optimized weights to the predictor fields produced better March-April-May (MAM) and September-October-November (SON) seasonal rain forecasts than a direct application of the same, unweighted predictor fields to CCA at both calibration and validation stages. Northeastern Tanzania and south-central Kenya had the best SON prediction results with both validation correlation and Hanssen-Kuipers skill scores exceeding +0.3. The MAM season was better predicted in the western parts of East Africa. The CCA correlation maps showed that low SON rainfall in East Africa is associated with cold SSTs off the Somali coast and the Benguela (Angola) coast, and low MAM rainfall is associated with a buildup of low SSTs in the Indian Ocean adjacent to East Africa and the Gulf of Guinea.

Comparison of JADE and canonical correlation analysis for ECG de-noising.

Science.gov (United States)

Kuzilek, Jakub; Kremen, Vaclav; Lhotska, Lenka

2014-01-01

This paper explores differences between two methods for blind source separation within frame of ECG de-noising. First method is joint approximate diagonalization of eigenmatrices, which is based on estimation of fourth order cross-cummulant tensor and its diagonalization. Second one is the statistical method known as canonical correlation analysis, which is based on estimation of correlation matrices between two multidimensional variables. Both methods were used within method, which combines the blind source separation algorithm with decision tree. The evaluation was made on large database of 382 long-term ECG signals and the results were examined. Biggest difference was found in results of 50 Hz power line interference where the CCA algorithm completely failed. Thus main power of CCA lies in estimation of unstructured noise within ECG. JADE algorithm has larger computational complexity thus the CCA perfomed faster when estimating the components.

The Application of Canonical Correlation to Two-Dimensional Contingency Tables

Directory of Open Access Journals (Sweden)

Alberto F. Restori

2010-03-01

Full Text Available This paper re-introduces and demonstrates the use of Mickey’s (1970 canonical correlation method in analyzing large two-dimensional contingency tables. This method of analysis supplements the traditional analysis using the Pearson chi-square. Examples and a MATLAB source listing are provided.

Personality Traits as Predictors of Shopping Motivations and Behaviors: A Canonical Correlation Analysis

Directory of Open Access Journals (Sweden)

Ali Gohary

2014-10-01

Full Text Available This study examines the relationship between Big Five personality traits with shopping motivation variables consisting of compulsive and impulsive buying, hedonic and utilitarian shopping values. Two hundred forty seven college students were recruited to participate in this research. Bivariate correlation demonstrates an overlap between personality traits; consequently, canonical correlation was performed to prevent this phenomenon. The results of multiple regression analysis suggested conscientiousness, neuroticism and openness as predictors of compulsive buying, impulsive buying and utilitarian shopping values. In addition, the results showed significant differences between males and females on conscientiousness, neuroticism, openness, compulsive buying and hedonic shopping value. Besides, using hierarchical regression analysis, we examined sex as moderator between Big Five personality traits and shopping variables, but we didn’t find sufficient evidence to prove it.

Social inequality, lifestyles and health - a non-linear canonical correlation analysis based on the approach of Pierre Bourdieu.

Science.gov (United States)

Grosse Frie, Kirstin; Janssen, Christian

2009-01-01

Based on the theoretical and empirical approach of Pierre Bourdieu, a multivariate non-linear method is introduced as an alternative way to analyse the complex relationships between social determinants and health. The analysis is based on face-to-face interviews with 695 randomly selected respondents aged 30 to 59. Variables regarding socio-economic status, life circumstances, lifestyles, health-related behaviour and health were chosen for the analysis. In order to determine whether the respondents can be differentiated and described based on these variables, a non-linear canonical correlation analysis (OVERALS) was performed. The results can be described on three dimensions; Eigenvalues add up to the fit of 1.444, which can be interpreted as approximately 50 % of explained variance. The three-dimensional space illustrates correspondences between variables and provides a framework for interpretation based on latent dimensions, which can be described by age, education, income and gender. Using non-linear canonical correlation analysis, health characteristics can be analysed in conjunction with socio-economic conditions and lifestyles. Based on Bourdieus theoretical approach, the complex correlations between these variables can be more substantially interpreted and presented.

Sparse and smooth canonical correlation analysis through rank-1 matrix approximation

Science.gov (United States)

Aïssa-El-Bey, Abdeldjalil; Seghouane, Abd-Krim

2017-12-01

Canonical correlation analysis (CCA) is a well-known technique used to characterize the relationship between two sets of multidimensional variables by finding linear combinations of variables with maximal correlation. Sparse CCA and smooth or regularized CCA are two widely used variants of CCA because of the improved interpretability of the former and the better performance of the later. So far, the cross-matrix product of the two sets of multidimensional variables has been widely used for the derivation of these variants. In this paper, two new algorithms for sparse CCA and smooth CCA are proposed. These algorithms differ from the existing ones in their derivation which is based on penalized rank-1 matrix approximation and the orthogonal projectors onto the space spanned by the two sets of multidimensional variables instead of the simple cross-matrix product. The performance and effectiveness of the proposed algorithms are tested on simulated experiments. On these results, it can be observed that they outperform the state of the art sparse CCA algorithms.

CANONICAL CORRELATION OF PHYSICAL AND CHEMICAL CHARACTERISTICS OF THE WOOD OF Eucalyptus grandis AND Eucalyptus saligna CLONES

Directory of Open Access Journals (Sweden)

Paulo Fernando Trugilho

2003-01-01

Full Text Available The analysis of canonical correlation measures the existence and the intensity of the association between two groups of variables. The research objectified to evaluate thecanonical correlation between chemical and physical characteristics and fiber dimensional ofwood of Eucalyptus grandis and Eucalyptus saligna clones, verifying the interdependenceamong the groups of studied variables. The analysis indicated that the canonical correlationswere high and that in two cases the first and second pair were significant at the level of 1% ofprobability. The analysis of canonical correlation showed that the groups are notindependent. The intergroup associations indicated that the wood of high insoluble lignin contentand low ash content is associated with the high radial and tangential contraction and highbasic density wood.

A canonical correlation neural network for multicollinearity and functional data.

Science.gov (United States)

Gou, Zhenkun; Fyfe, Colin

2004-03-01

We review a recent neural implementation of Canonical Correlation Analysis and show, using ideas suggested by Ridge Regression, how to make the algorithm robust. The network is shown to operate on data sets which exhibit multicollinearity. We develop a second model which not only performs as well on multicollinear data but also on general data sets. This model allows us to vary a single parameter so that the network is capable of performing Partial Least Squares regression (at one extreme) to Canonical Correlation Analysis (at the other)and every intermediate operation between the two. On multicollinear data, the parameter setting is shown to be important but on more general data no particular parameter setting is required. Finally, we develop a second penalty term which acts on such data as a smoother in that the resulting weight vectors are much smoother and more interpretable than the weights without the robustification term. We illustrate our algorithms on both artificial and real data.

Structure-constrained sparse canonical correlation analysis with an application to microbiome data analysis.

Science.gov (United States)

Chen, Jun; Bushman, Frederic D; Lewis, James D; Wu, Gary D; Li, Hongzhe

2013-04-01

Motivated by studying the association between nutrient intake and human gut microbiome composition, we developed a method for structure-constrained sparse canonical correlation analysis (ssCCA) in a high-dimensional setting. ssCCA takes into account the phylogenetic relationships among bacteria, which provides important prior knowledge on evolutionary relationships among bacterial taxa. Our ssCCA formulation utilizes a phylogenetic structure-constrained penalty function to impose certain smoothness on the linear coefficients according to the phylogenetic relationships among the taxa. An efficient coordinate descent algorithm is developed for optimization. A human gut microbiome data set is used to illustrate this method. Both simulations and real data applications show that ssCCA performs better than the standard sparse CCA in identifying meaningful variables when there are structures in the data.

Canonical correlation analysis for gene-based pleiotropy discovery.

Directory of Open Access Journals (Sweden)

Jose A Seoane

2014-10-01

Full Text Available Genome-wide association studies have identified a wealth of genetic variants involved in complex traits and multifactorial diseases. There is now considerable interest in testing variants for association with multiple phenotypes (pleiotropy and for testing multiple variants for association with a single phenotype (gene-based association tests. Such approaches can increase statistical power by combining evidence for association over multiple phenotypes or genetic variants respectively. Canonical Correlation Analysis (CCA measures the correlation between two sets of multidimensional variables, and thus offers the potential to combine these two approaches. To apply CCA, we must restrict the number of attributes relative to the number of samples. Hence we consider modules of genetic variation that can comprise a gene, a pathway or another biologically relevant grouping, and/or a set of phenotypes. In order to do this, we use an attribute selection strategy based on a binary genetic algorithm. Applied to a UK-based prospective cohort study of 4286 women (the British Women's Heart and Health Study, we find improved statistical power in the detection of previously reported genetic associations, and identify a number of novel pleiotropic associations between genetic variants and phenotypes. New discoveries include gene-based association of NSF with triglyceride levels and several genes (ACSM3, ERI2, IL18RAP, IL23RAP and NRG1 with left ventricular hypertrophy phenotypes. In multiple-phenotype analyses we find association of NRG1 with left ventricular hypertrophy phenotypes, fibrinogen and urea and pleiotropic relationships of F7 and F10 with Factor VII, Factor IX and cholesterol levels.

A canonical correlation analysis based EMG classification algorithm for eliminating electrode shift effect.

Science.gov (United States)

Zhe Fan; Zhong Wang; Guanglin Li; Ruomei Wang

2016-08-01

Motion classification system based on surface Electromyography (sEMG) pattern recognition has achieved good results in experimental condition. But it is still a challenge for clinical implement and practical application. Many factors contribute to the difficulty of clinical use of the EMG based dexterous control. The most obvious and important is the noise in the EMG signal caused by electrode shift, muscle fatigue, motion artifact, inherent instability of signal and biological signals such as Electrocardiogram. In this paper, a novel method based on Canonical Correlation Analysis (CCA) was developed to eliminate the reduction of classification accuracy caused by electrode shift. The average classification accuracy of our method were above 95% for the healthy subjects. In the process, we validated the influence of electrode shift on motion classification accuracy and discovered the strong correlation with correlation coefficient of >0.9 between shift position data and normal position data.

Sparse Canonical Correlation Analysis via Truncated ℓ1-norm with Application to Brain Imaging Genetics.

Science.gov (United States)

Du, Lei; Zhang, Tuo; Liu, Kefei; Yao, Xiaohui; Yan, Jingwen; Risacher, Shannon L; Guo, Lei; Saykin, Andrew J; Shen, Li

2016-01-01

Discovering bi-multivariate associations between genetic markers and neuroimaging quantitative traits is a major task in brain imaging genetics. Sparse Canonical Correlation Analysis (SCCA) is a popular technique in this area for its powerful capability in identifying bi-multivariate relationships coupled with feature selection. The existing SCCA methods impose either the ℓ 1 -norm or its variants. The ℓ 0 -norm is more desirable, which however remains unexplored since the ℓ 0 -norm minimization is NP-hard. In this paper, we impose the truncated ℓ 1 -norm to improve the performance of the ℓ 1 -norm based SCCA methods. Besides, we propose two efficient optimization algorithms and prove their convergence. The experimental results, compared with two benchmark methods, show that our method identifies better and meaningful canonical loading patterns in both simulated and real imaging genetic analyse.

Canonical analysis of sentinel-1 radar and sentinel-2 optical data

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Larsen, Rasmus

2017-01-01

This paper gives results from joint analyses of dual polarimety synthetic aperture radar data from the Sentinel-1 mission and optical data from the Sentinel-2 mission. The analyses are carried out by means of traditional canonical correlation analysis (CCA) and canonical information analysis (CIA......). Where CCA is based on maximising correlation between linear combinations of the two data sets, CIA maximises mutual information between the two. CIA is a conceptually more pleasing method for the analysis of data with very different modalities such as radar and optical data. Although a little...

Relationship between organisational commitment and burnout syndrome: a canonical correlation approach.

Science.gov (United States)

Enginyurt, Ozgur; Cankaya, Soner; Aksay, Kadir; Tunc, Taner; Koc, Bozkurt; Bas, Orhan; Ozer, Erdal

2016-04-01

Objective Burnout syndrome can significantly reduce the performance of health workers. Although many factors have been identified as antecedents of burnout, few studies have investigated the role of organisational commitment in its development. The purpose of the present study was to examine the relationships between subdimensions of burnout syndrome (emotional exhaustion, depersonalisation and personal accomplishment) and subdimensions of organisational commitment (affective commitment, continuance commitment and normative commitment). Methods The present study was a cross-sectional survey of physicians and other healthcare employees working in the Ministry of Health Ordu University Education and Research Hospital. The sample consisted of 486 healthcare workers. Data were collected using the Maslach Burnout Inventory and the Organisation Commitment Scale, and were analysed using the canonical correlation approach. Results The first of three canonical correlation coefficients between pairs of canonical variables (Ui , burnout syndrome and Vi, organisational commitment) was found to be statistically significant. Emotional exhaustion was found to contribute most towards the explanatory capacity of canonical variables estimated from the subdimensions of burnout syndrome, whereas affective commitment provided the largest contribution towards the explanatory capacity of canonical variables estimated from the subdimensions of organisational commitment. Conclusions The results of the present study indicate that affective commitment is the primary determinant of burnout syndrome in healthcare professionals. What is known about the topic? Organisational commitment and burnout syndrome are the most important criteria in predicting health workforce performance. An increasing number of studies in recent years have clearly indicated the field's continued relevance and importance. Conversely, canonical correlation analysis (CCA) is a technique for describing the relationship

Multidimensional correlation among plan complexity, quality and deliverability parameters for volumetric-modulated arc therapy using canonical correlation analysis.

Science.gov (United States)

Shen, Lanxiao; Chen, Shan; Zhu, Xiaoyang; Han, Ce; Zheng, Xiaomin; Deng, Zhenxiang; Zhou, Yongqiang; Gong, Changfei; Xie, Congying; Jin, Xiance

2018-03-01

A multidimensional exploratory statistical method, canonical correlation analysis (CCA), was applied to evaluate the impact of complexity parameters on the plan quality and deliverability of volumetric-modulated arc therapy (VMAT) and to determine parameters in the generation of an ideal VMAT plan. Canonical correlations among complexity, quality and deliverability parameters of VMAT, as well as the contribution weights of different parameters were investigated with 71 two-arc VMAT nasopharyngeal cancer (NPC) patients, and further verified with 28 one-arc VMAT prostate cancer patients. The average MU and MU per control point (MU/CP) for two-arc VMAT plans were 702.6 ± 55.7 and 3.9 ± 0.3 versus 504.6 ± 99.2 and 5.6 ± 1.1 for one-arc VMAT plans, respectively. The individual volume-based 3D gamma passing rates of clinical target volume (γCTV) and planning target volume (γPTV) for NPC and prostate cancer patients were 85.7% ± 9.0% vs 92.6% ± 7.8%, and 88.0% ± 7.6% vs 91.2% ± 7.7%, respectively. Plan complexity parameters of NPC patients were correlated with plan quality (P = 0.047) and individual volume-based 3D gamma indices γ(IV) (P = 0.01), in which, MU/CP and segment area (SA) per control point (SA/CP) were weighted highly in correlation with γ(IV) , and SA/CP, percentage of CPs with SA plan quality with coefficients of 0.98, 0.68 and -0.99, respectively. Further verification with one-arc VMAT plans demonstrated similar results. In conclusion, MU, SA-related parameters and PTV volume were found to have strong effects on the plan quality and deliverability.

fCCAC: functional canonical correlation analysis to evaluate covariance between nucleic acid sequencing datasets.

Science.gov (United States)

Madrigal, Pedro

2017-03-01

Computational evaluation of variability across DNA or RNA sequencing datasets is a crucial step in genomic science, as it allows both to evaluate reproducibility of biological or technical replicates, and to compare different datasets to identify their potential correlations. Here we present fCCAC, an application of functional canonical correlation analysis to assess covariance of nucleic acid sequencing datasets such as chromatin immunoprecipitation followed by deep sequencing (ChIP-seq). We show how this method differs from other measures of correlation, and exemplify how it can reveal shared covariance between histone modifications and DNA binding proteins, such as the relationship between the H3K4me3 chromatin mark and its epigenetic writers and readers. An R/Bioconductor package is available at http://bioconductor.org/packages/fCCAC/ . pmb59@cam.ac.uk. Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

Canonical correlation analysis of infant's size at birth and maternal factors: a study in rural northwest Bangladesh.

Science.gov (United States)

Kabir, Alamgir; Merrill, Rebecca D; Shamim, Abu Ahmed; Klemn, Rolf D W; Labrique, Alain B; Christian, Parul; West, Keith P; Nasser, Mohammed

2014-01-01

This analysis was conducted to explore the association between 5 birth size measurements (weight, length and head, chest and mid-upper arm [MUAC] circumferences) as dependent variables and 10 maternal factors as independent variables using canonical correlation analysis (CCA). CCA considers simultaneously sets of dependent and independent variables and, thus, generates a substantially reduced type 1 error. Data were from women delivering a singleton live birth (n = 14,506) while participating in a double-masked, cluster-randomized, placebo-controlled maternal vitamin A or β-carotene supplementation trial in rural Bangladesh. The first canonical correlation was 0.42 (P<0.001), demonstrating a moderate positive correlation mainly between the 5 birth size measurements and 5 maternal factors (preterm delivery, early pregnancy MUAC, infant sex, age and parity). A significant interaction between infant sex and preterm delivery on birth size was also revealed from the score plot. Thirteen percent of birth size variability was explained by the composite score of the maternal factors (Redundancy, RY/X = 0.131). Given an ability to accommodate numerous relationships and reduce complexities of multiple comparisons, CCA identified the 5 maternal variables able to predict birth size in this rural Bangladesh setting. CCA may offer an efficient, practical and inclusive approach to assessing the association between two sets of variables, addressing the innate complexity of interactions.

Canonical correlation analysis of infant's size at birth and maternal factors: a study in rural northwest Bangladesh.

Directory of Open Access Journals (Sweden)

Alamgir Kabir

Full Text Available This analysis was conducted to explore the association between 5 birth size measurements (weight, length and head, chest and mid-upper arm [MUAC] circumferences as dependent variables and 10 maternal factors as independent variables using canonical correlation analysis (CCA. CCA considers simultaneously sets of dependent and independent variables and, thus, generates a substantially reduced type 1 error. Data were from women delivering a singleton live birth (n = 14,506 while participating in a double-masked, cluster-randomized, placebo-controlled maternal vitamin A or β-carotene supplementation trial in rural Bangladesh. The first canonical correlation was 0.42 (P<0.001, demonstrating a moderate positive correlation mainly between the 5 birth size measurements and 5 maternal factors (preterm delivery, early pregnancy MUAC, infant sex, age and parity. A significant interaction between infant sex and preterm delivery on birth size was also revealed from the score plot. Thirteen percent of birth size variability was explained by the composite score of the maternal factors (Redundancy, RY/X = 0.131. Given an ability to accommodate numerous relationships and reduce complexities of multiple comparisons, CCA identified the 5 maternal variables able to predict birth size in this rural Bangladesh setting. CCA may offer an efficient, practical and inclusive approach to assessing the association between two sets of variables, addressing the innate complexity of interactions.

The relationship between procrastination, learning strategies and statistics anxiety among Iranian college students: a canonical correlation analysis.

Science.gov (United States)

Vahedi, Shahrum; Farrokhi, Farahman; Gahramani, Farahnaz; Issazadegan, Ali

2012-01-01

Approximately 66-80%of graduate students experience statistics anxiety and some researchers propose that many students identify statistics courses as the most anxiety-inducing courses in their academic curriculums. As such, it is likely that statistics anxiety is, in part, responsible for many students delaying enrollment in these courses for as long as possible. This paper proposes a canonical model by treating academic procrastination (AP), learning strategies (LS) as predictor variables and statistics anxiety (SA) as explained variables. A questionnaire survey was used for data collection and 246-college female student participated in this study. To examine the mutually independent relations between procrastination, learning strategies and statistics anxiety variables, a canonical correlation analysis was computed. Findings show that two canonical functions were statistically significant. The set of variables (metacognitive self-regulation, source management, preparing homework, preparing for test and preparing term papers) helped predict changes of statistics anxiety with respect to fearful behavior, Attitude towards math and class, Performance, but not Anxiety. These findings could be used in educational and psychological interventions in the context of statistics anxiety reduction.

Pyrcca: Regularized Kernel Canonical Correlation Analysis in Python and Its Applications to Neuroimaging.

Science.gov (United States)

Bilenko, Natalia Y; Gallant, Jack L

2016-01-01

In this article we introduce Pyrcca, an open-source Python package for performing canonical correlation analysis (CCA). CCA is a multivariate analysis method for identifying relationships between sets of variables. Pyrcca supports CCA with or without regularization, and with or without linear, polynomial, or Gaussian kernelization. We first use an abstract example to describe Pyrcca functionality. We then demonstrate how Pyrcca can be used to analyze neuroimaging data. Specifically, we use Pyrcca to implement cross-subject comparison in a natural movie functional magnetic resonance imaging (fMRI) experiment by finding a data-driven set of functional response patterns that are similar across individuals. We validate this cross-subject comparison method in Pyrcca by predicting responses to novel natural movies across subjects. Finally, we show how Pyrcca can reveal retinotopic organization in brain responses to natural movies without the need for an explicit model.

Hard and soft tissue correlations in facial profiles: a canonical correlation study

Directory of Open Access Journals (Sweden)

Shamlan MA

2015-01-01

Full Text Available Manal A Shamlan,1 Abdullah M Aldrees2 1Faculty of Dentistry, King Abdulaziz University, Jeddah, 2Division of Orthodontics, Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, Saudi Arabia Background: The purpose of this study was to analyze the relationship between facial hard and soft tissues in normal Saudi individuals by studying the canonical correlation between specific hard tissue landmarks and their corresponding soft tissue landmarks. Methods: A retrospective, cross-sectional study was designed, with a sample size of 60 Saudi adults (30 males and 30 females who had a class I skeletal and dental relationship and normal occlusion. Lateral cephalometric radiographs of the study sample were investigated using a series of 29 linear and angular measurements of hard and soft tissue features. The measurements were calculated electronically using Dolphin® software, and the data were analyzed using canonical correlation. Results: Eighty-four percent of the variation in the soft tissue was explained by the variation in hard tissue. Conclusion: The position of the upper and lower incisors and inclination of the lower incisors influence upper lip length and lower lip position. The inclination of the upper incisors is associated with lower lip length. Keywords: facial profile, hard tissue, soft tissue, canonical correlation

Canonical Correlation Analysis Between Supply Chain Quality Management And Competitive Advantages

Directory of Open Access Journals (Sweden)

Chaghooshi Ahmad Jafarnejad

2015-06-01

Full Text Available Competitive environment of today’s organizations, more than ever, is extensive, and the major concern for managers is to preserve and promote the sustainable competitive advantage. Companies have an obligation to improve their product quality and have extensive and close cooperation with other companies involved in the supply chain of products. Supply chain quality management (SCQM is a systematic approach to improve the performance that integrates supply chain partners and uses the opportunity in the best way, establish linkages between upstream and downstream flows, and investigate on creating value and satisfaction of intermediaries and final customers. Furthermore, achieving competitive advantages enables an organization to create a remarkable position in market and differentiate itself from competitors. This paper aims to understand the relationships between SCQM and competitive advantage. Sixty-eight experts of 25 companies in Sahami Alyaf (SA supply chain has been participated in this research. The research method used for this article is descriptive correlation. To assess the relationships between the criteria, canonical correlation analysis was used. The result shows that the SCQM and competitive advantages have a meaningful relationship. It also shows that most important variable in the linear combination of SCQM and competitive advantages are “customer focus and quality,” respectively.

Pyrcca: regularized kernel canonical correlation analysis in Python and its applications to neuroimaging

Directory of Open Access Journals (Sweden)

Natalia Y Bilenko

2016-11-01

Full Text Available In this article we introduce Pyrcca, an open-source Python package for performing canonical correlation analysis (CCA. CCA is a multivariate analysis method for identifying relationships between sets of variables. Pyrcca supports CCA with or without regularization, and with or without linear, polynomial, or Gaussian kernelization. We first use an abstract example to describe Pyrcca functionality. We then demonstrate how Pyrcca can be used to analyze neuroimaging data. Specifically, we use Pyrcca to implement cross-subject comparison in a natural movie functional magnetic resonance imaging (fMRI experiment by finding a data-driven set of functional response patterns that are similar across individuals. We validate this cross-subject comparison method in Pyrcca by predicting responses to novel natural movies across subjects. Finally, we show how Pyrcca can reveal retinotopic organization in brain responses to natural movies without the need for an explicit model.

Applications of temporal kernel canonical correlation analysis in adherence studies.

Science.gov (United States)

John, Majnu; Lencz, Todd; Ferbinteanu, Janina; Gallego, Juan A; Robinson, Delbert G

2017-10-01

Adherence to medication is often measured as a continuous outcome but analyzed as a dichotomous outcome due to lack of appropriate tools. In this paper, we illustrate the use of the temporal kernel canonical correlation analysis (tkCCA) as a method to analyze adherence measurements and symptom levels on a continuous scale. The tkCCA is a novel method developed for studying the relationship between neural signals and hemodynamic response detected by functional MRI during spontaneous activity. Although the tkCCA is a powerful tool, it has not been utilized outside the application that it was originally developed for. In this paper, we simulate time series of symptoms and adherence levels for patients with a hypothetical brain disorder and show how the tkCCA can be used to understand the relationship between them. We also examine, via simulations, the behavior of the tkCCA under various missing value mechanisms and imputation methods. Finally, we apply the tkCCA to a real data example of psychotic symptoms and adherence levels obtained from a study based on subjects with a first episode of schizophrenia, schizophreniform or schizoaffective disorder.

The Relationship Between Procrastination, Learning Strategies and Statistics Anxiety Among Iranian College Students: A Canonical Correlation Analysis

Science.gov (United States)

Vahedi, Shahrum; Farrokhi, Farahman; Gahramani, Farahnaz; Issazadegan, Ali

2012-01-01

Objective: Approximately 66-80%of graduate students experience statistics anxiety and some researchers propose that many students identify statistics courses as the most anxiety-inducing courses in their academic curriculums. As such, it is likely that statistics anxiety is, in part, responsible for many students delaying enrollment in these courses for as long as possible. This paper proposes a canonical model by treating academic procrastination (AP), learning strategies (LS) as predictor variables and statistics anxiety (SA) as explained variables. Methods: A questionnaire survey was used for data collection and 246-college female student participated in this study. To examine the mutually independent relations between procrastination, learning strategies and statistics anxiety variables, a canonical correlation analysis was computed. Results: Findings show that two canonical functions were statistically significant. The set of variables (metacognitive self-regulation, source management, preparing homework, preparing for test and preparing term papers) helped predict changes of statistics anxiety with respect to fearful behavior, Attitude towards math and class, Performance, but not Anxiety. Conclusion: These findings could be used in educational and psychological interventions in the context of statistics anxiety reduction. PMID:24644468

The integrated model of sport confidence: a canonical correlation and mediational analysis.

Science.gov (United States)

Koehn, Stefan; Pearce, Alan J; Morris, Tony

2013-12-01

The main purpose of the study was to examine crucial parts of Vealey's (2001) integrated framework hypothesizing that sport confidence is a mediating variable between sources of sport confidence (including achievement, self-regulation, and social climate) and athletes' affect in competition. The sample consisted of 386 athletes, who completed the Sources of Sport Confidence Questionnaire, Trait Sport Confidence Inventory, and Dispositional Flow Scale-2. Canonical correlation analysis revealed a confidence-achievement dimension underlying flow. Bias-corrected bootstrap confidence intervals in AMOS 20.0 were used in examining mediation effects between source domains and dispositional flow. Results showed that sport confidence partially mediated the relationship between achievement and self-regulation domains and flow, whereas no significant mediation was found for social climate. On a subscale level, full mediation models emerged for achievement and flow dimensions of challenge-skills balance, clear goals, and concentration on the task at hand.

Filter bank canonical correlation analysis for implementing a high-speed SSVEP-based brain-computer interface

Science.gov (United States)

Chen, Xiaogang; Wang, Yijun; Gao, Shangkai; Jung, Tzyy-Ping; Gao, Xiaorong

2015-08-01

Objective. Recently, canonical correlation analysis (CCA) has been widely used in steady-state visual evoked potential (SSVEP)-based brain-computer interfaces (BCIs) due to its high efficiency, robustness, and simple implementation. However, a method with which to make use of harmonic SSVEP components to enhance the CCA-based frequency detection has not been well established. Approach. This study proposed a filter bank canonical correlation analysis (FBCCA) method to incorporate fundamental and harmonic frequency components to improve the detection of SSVEPs. A 40-target BCI speller based on frequency coding (frequency range: 8-15.8 Hz, frequency interval: 0.2 Hz) was used for performance evaluation. To optimize the filter bank design, three methods (M1: sub-bands with equally spaced bandwidths; M2: sub-bands corresponding to individual harmonic frequency bands; M3: sub-bands covering multiple harmonic frequency bands) were proposed for comparison. Classification accuracy and information transfer rate (ITR) of the three FBCCA methods and the standard CCA method were estimated using an offline dataset from 12 subjects. Furthermore, an online BCI speller adopting the optimal FBCCA method was tested with a group of 10 subjects. Main results. The FBCCA methods significantly outperformed the standard CCA method. The method M3 achieved the highest classification performance. At a spelling rate of ˜33.3 characters/min, the online BCI speller obtained an average ITR of 151.18 ± 20.34 bits min-1. Significance. By incorporating the fundamental and harmonic SSVEP components in target identification, the proposed FBCCA method significantly improves the performance of the SSVEP-based BCI, and thereby facilitates its practical applications such as high-speed spelling.

Attenuation of the Squared Canonical Correlation Coefficient under Varying Estimates of Score Reliability

Science.gov (United States)

Wilson, Celia M.

2010-01-01

Research pertaining to the distortion of the squared canonical correlation coefficient has traditionally been limited to the effects of sampling error and associated correction formulas. The purpose of this study was to compare the degree of attenuation of the squared canonical correlation coefficient under varying conditions of score reliability.…

SU-F-P-64: The Impact of Plan Complexity Parameters On the Plan Quality and Deliverability of Volumetric Modulated Arc Therapy with Canonical Correlation Analysis

Energy Technology Data Exchange (ETDEWEB)

Jin, X; Yi, J; Xie, C [The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang (China)

2016-06-15

Purpose: To evaluate the impact of complexity indices on the plan quality and deliverability of volumetric modulated arc therapy (VMAT), and to determine the most significant parameters in the generation of an ideal VMAT plan. Methods: A multi-dimensional exploratory statistical method, canonical correlation analysis (CCA) was adopted to study the correlations between VMAT parameters of complexity, quality and deliverability, as well as their contribution weights with 32 two-arc VMAT nasopharyngeal cancer (NPC) patients and 31 one-arc VMAT prostate cancer patients. Results: The MU per arc (MU/Arc) and MU per control point (MU/CP) of NPC were 337.8±25.2 and 3.7±0.3, respectively, which were significantly lower than those of prostate cancer patients (MU/Arc : 506.9±95.4, MU/CP : 5.6±1.1). The plan complexity indices indicated that two-arc VMAT plans were more complex than one-arc VMAT plans. Plan quality comparison confirmed that one-arc VMAT plans had a high quality than two-arc VMAT plans. CCA results implied that plan complexity parameters were highly correlated with plan quality with the first two canonical correlations of 0.96, 0.88 (both p<0.001) and significantly correlated with deliverability with the first canonical correlation of 0.79 (p<0.001), plan quality and deliverability was also correlated with the first canonical correlation of 0.71 (p=0.02). Complexity parameters of MU/CP, segment area (SA) per CP, percent of MU/CP less 3 and planning target volume (PTV) were weighted heavily in correlation with plan quality and deliveability . Similar results obtained from individual NPC and prostate CCA analysis. Conclusion: Relationship between complexity, quality, and deliverability parameters were investigated with CCA. MU, SA related parameters and PTV volume were found to have strong effect on the plan quality and deliverability. The presented correlation among different quantified parameters could be used to improve the plan quality and the efficiency

Analysis of input variables of an artificial neural network using bivariate correlation and canonical correlation

Energy Technology Data Exchange (ETDEWEB)

Costa, Valter Magalhaes; Pereira, Iraci Martinez, E-mail: valter.costa@usp.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2011-07-01

The monitoring of variables and diagnosis of sensor fault in nuclear power plants or processes industries is very important because a previous diagnosis allows the correction of the fault and, like this, to prevent the production stopped, improving operator's security and it's not provoking economics losses. The objective of this work is to build a set, using bivariate correlation and canonical correlation, which will be the set of input variables of an artificial neural network to monitor the greater number of variables. This methodology was applied to the IEA-R1 Research Reactor at IPEN. Initially, for the input set of neural network we selected the variables: nuclear power, primary circuit flow rate, control/safety rod position and difference in pressure in the core of the reactor, because almost whole of monitoring variables have relation with the variables early described or its effect can be result of the interaction of two or more. The nuclear power is related to the increasing and decreasing of temperatures as well as the amount radiation due fission of the uranium; the rods are controls of power and influence in the amount of radiation and increasing and decreasing of temperatures; the primary circuit flow rate has the function of energy transport by removing the nucleus heat. An artificial neural network was trained and the results were satisfactory since the IEA-R1 Data Acquisition System reactor monitors 64 variables and, with a set of 9 input variables resulting from the correlation analysis, it was possible to monitor 51 variables. (author)

Analysis of input variables of an artificial neural network using bivariate correlation and canonical correlation

International Nuclear Information System (INIS)

Costa, Valter Magalhaes; Pereira, Iraci Martinez

2011-01-01

The monitoring of variables and diagnosis of sensor fault in nuclear power plants or processes industries is very important because a previous diagnosis allows the correction of the fault and, like this, to prevent the production stopped, improving operator's security and it's not provoking economics losses. The objective of this work is to build a set, using bivariate correlation and canonical correlation, which will be the set of input variables of an artificial neural network to monitor the greater number of variables. This methodology was applied to the IEA-R1 Research Reactor at IPEN. Initially, for the input set of neural network we selected the variables: nuclear power, primary circuit flow rate, control/safety rod position and difference in pressure in the core of the reactor, because almost whole of monitoring variables have relation with the variables early described or its effect can be result of the interaction of two or more. The nuclear power is related to the increasing and decreasing of temperatures as well as the amount radiation due fission of the uranium; the rods are controls of power and influence in the amount of radiation and increasing and decreasing of temperatures; the primary circuit flow rate has the function of energy transport by removing the nucleus heat. An artificial neural network was trained and the results were satisfactory since the IEA-R1 Data Acquisition System reactor monitors 64 variables and, with a set of 9 input variables resulting from the correlation analysis, it was possible to monitor 51 variables. (author)

Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of metabolic syndrome

Directory of Open Access Journals (Sweden)

Gaora Peadar Ó

2010-10-01

Full Text Available Abstract Background Currently, a number of bioinformatics methods are available to generate appropriate lists of genes from a microarray experiment. While these lists represent an accurate primary analysis of the data, fewer options exist to contextualise those lists. The development and validation of such methods is crucial to the wider application of microarray technology in the clinical setting. Two key challenges in clinical bioinformatics involve appropriate statistical modelling of dynamic transcriptomic changes, and extraction of clinically relevant meaning from very large datasets. Results Here, we apply an approach to gene set enrichment analysis that allows for detection of bi-directional enrichment within a gene set. Furthermore, we apply canonical correlation analysis and Fisher's exact test, using plasma marker data with known clinical relevance to aid identification of the most important gene and pathway changes in our transcriptomic dataset. After a 28-day dietary intervention with high-CLA beef, a range of plasma markers indicated a marked improvement in the metabolic health of genetically obese mice. Tissue transcriptomic profiles indicated that the effects were most dramatic in liver (1270 genes significantly changed; p Conclusion Bi-directional gene set enrichment analysis more accurately reflects dynamic regulatory behaviour in biochemical pathways, and as such highlighted biologically relevant changes that were not detected using a traditional approach. In such cases where transcriptomic response to treatment is exceptionally large, canonical correlation analysis in conjunction with Fisher's exact test highlights the subset of pathways showing strongest correlation with the clinical markers of interest. In this case, we have identified selenoamino acid metabolism and steroid biosynthesis as key pathways mediating the observed relationship between metabolic health and high-CLA beef. These results indicate that this type of

Adaptive Kernel Canonical Correlation Analysis Algorithms for Nonparametric Identification of Wiener and Hammerstein Systems

Directory of Open Access Journals (Sweden)

Ignacio Santamaría

2008-04-01

Full Text Available This paper treats the identification of nonlinear systems that consist of a cascade of a linear channel and a nonlinearity, such as the well-known Wiener and Hammerstein systems. In particular, we follow a supervised identification approach that simultaneously identifies both parts of the nonlinear system. Given the correct restrictions on the identification problem, we show how kernel canonical correlation analysis (KCCA emerges as the logical solution to this problem. We then extend the proposed identification algorithm to an adaptive version allowing to deal with time-varying systems. In order to avoid overfitting problems, we discuss and compare three possible regularization techniques for both the batch and the adaptive versions of the proposed algorithm. Simulations are included to demonstrate the effectiveness of the presented algorithm.

Rainfall prediction of Cimanuk watershed regions with canonical correlation analysis (CCA)

Science.gov (United States)

Rustiana, Shailla; Nurani Ruchjana, Budi; Setiawan Abdullah, Atje; Hermawan, Eddy; Berliana Sipayung, Sinta; Gede Nyoman Mindra Jaya, I.; Krismianto

2017-10-01

Rainfall prediction in Indonesia is very influential on various development sectors, such as agriculture, fisheries, water resources, industry, and other sectors. The inaccurate predictions can lead to negative effects. Cimanuk watershed is one of the main pillar of water resources in West Java. This watersheds divided into three parts, which is a headwater of Cimanuk sub-watershed, Middle of Cimanuk sub-watershed and downstream of Cimanuk sub- watershed. The flow of this watershed will flow through the Jatigede reservoir and will supply water to the north-coast area in the next few years. So, the reliable model of rainfall prediction is very needed in this watershed. Rainfall prediction conducted with Canonical Correlation Analysis (CCA) method using Climate Predictability Tool (CPT) software. The prediction is every 3months on 2016 (after January) based on Climate Hazards group Infrared Precipitation with Stations (CHIRPS) data over West Java. Predictors used in CPT were the monthly data index of Nino3.4, Dipole Mode (DMI), and Monsoon Index (AUSMI-ISMI-WNPMI-WYMI) with initial condition January. The initial condition is chosen by the last data update. While, the predictant were monthly rainfall data CHIRPS region of West Java. The results of prediction rainfall showed by skill map from Pearson Correlation. High correlation of skill map are on MAM (Mar-Apr-May), AMJ (Apr-May-Jun), and JJA (Jun-Jul-Aug) which means the model is reliable to forecast rainfall distribution over Cimanuk watersheds region (over West Java) on those seasons. CCA score over those season prediction mostly over 0.7. The accuracy of the model CPT also indicated by the Relative Operating Characteristic (ROC) curve of the results of Pearson correlation 3 representative point of sub-watershed (Sumedang, Majalengka, and Cirebon), were mostly located in the top line of non-skill, and evidenced by the same of rainfall patterns between observation and forecast. So, the model of CPT with CCA method

A canonical correlation analysis-based dynamic bayesian network prior to infer gene regulatory networks from multiple types of biological data.

Science.gov (United States)

Baur, Brittany; Bozdag, Serdar

2015-04-01

One of the challenging and important computational problems in systems biology is to infer gene regulatory networks (GRNs) of biological systems. Several methods that exploit gene expression data have been developed to tackle this problem. In this study, we propose the use of copy number and DNA methylation data to infer GRNs. We developed an algorithm that scores regulatory interactions between genes based on canonical correlation analysis. In this algorithm, copy number or DNA methylation variables are treated as potential regulator variables, and expression variables are treated as potential target variables. We first validated that the canonical correlation analysis method is able to infer true interactions in high accuracy. We showed that the use of DNA methylation or copy number datasets leads to improved inference over steady-state expression. Our results also showed that epigenetic and structural information could be used to infer directionality of regulatory interactions. Additional improvements in GRN inference can be gleaned from incorporating the result in an informative prior in a dynamic Bayesian algorithm. This is the first study that incorporates copy number and DNA methylation into an informative prior in dynamic Bayesian framework. By closely examining top-scoring interactions with different sources of epigenetic or structural information, we also identified potential novel regulatory interactions.

Quantum correlations of ideal Bose and Fermi gases in the canonical ensemble

International Nuclear Information System (INIS)

Tsutsui, Kazumasa; Kita, Takafumi

2016-01-01

We derive an expression for the reduced density matrices of ideal Bose and Fermi gases in the canonical ensemble, which corresponds to the Bloch-De Dominicis (or Wick's) theorem in the grand canonical ensemble for normal-ordered products of operators. Using this expression, we study one- and two-body correlations of homogeneous ideal gases with N particles. The pair distribution function g (2) (r) of fermions clearly exhibits antibunching with g (2) (0) = 0 due to the Pauli exclusion principle at all temperatures, whereas that of normal bosons shows bunching with g (2) (0) ≈ 2, corresponding to the Hanbury Brown-Twiss effect. For bosons below the Bose-Einstein condensation temperature T 0 , an off-diagonal long-range order develops in the one-particle density matrix to reach g (1) (r) = 1 at T = 0, and the pair correlation starts to decrease towards g (2) (r) ≈ 1 at T = 0. The results for N → ∞ are seen to converge to those of the grand canonical ensemble obtained by assuming the average <ψ(r)> of the field operator ψ(r) below T 0 . This fact justifies the introduction of the 'anomalous' average <ψ(r)> ≠ 0 below T 0 in the grand canonical ensemble as a mathematical means of removing unphysical particle-number fluctuations to reproduce the canonical results in the thermodynamic limit. (author)

Canonical correlations between agronomic traits and seed physiological quality in segregating soybean populations.

Science.gov (United States)

Pereira, E M; Silva, F M; Val, B H P; Pizolato Neto, A; Mauro, A O; Martins, C C; Unêda-Trevisoli, S H

2017-04-13

The objective of this study was to evaluate the relationship between agronomic traits and physiological traits of seeds in segregating soybean populations by canonical correlation analysis. Seven populations and two commercial cultivars in three generations were used: F 3 plants and F 4 seeds; F 4 plants and F 5 seeds, and F 4 seeds and plants. The following agronomic traits (group I) were evaluated: number of days to maturity, plant height at maturity, insertion height of first pod, number of pods, grain yield, and oil content. The physiological quality of seeds (group II) was evaluated using germination, accelerated aging, emergence, and emergence rate index tests. The results showed that agronomic traits and physiological traits of seeds are not independent. Intergroup associations were established by the first canonical pair for the generation of F 3 plants and F 4 seeds, especially between more productive plants with a larger pod number and high oil content and seeds with a high germination percentage and emergence rate. For the generation of F 4 plants and F 5 seeds, the first canonical pair indicated an association between reduced maturity cycle, seeds with a high emergence percentage and a high percentage of normal seedlings after accelerated aging. According to the second canonical pair, more productive and taller plants were associated with seed vigor. For the generation of F 4 seeds and plants, the associations established by the first canonical pair occurred between seed vigor and more productive plants with high oil content and reduced maturity cycle, and those established by the second canonical pair between seeds of high physiological quality and tall plants.

The Quality of Life of Hemodialysis Patients Is Affected Not Only by Medical but also Psychosocial Factors: a Canonical Correlation Study.

Science.gov (United States)

Kim, Kyungmin; Kang, Gun Woo; Woo, Jungmin

2018-04-02

The quality of life (QoL) of patients with end-stage renal disease (ESRD) is very poor, plausibly due to both psychosocial and medical factors. This study aimed to determine the relationship among psychosocial factors, medical factors, and QoL in patients with ESRD undergoing hemodialysis (HD). In total, 55 male and 47 female patients were evaluated (mean age, 57.1 ± 12.0 years). The QoL was evaluated using the Korean version of World Health Organization Quality of Life Scale-Abbreviated Version. The psychosocial factors were evaluated using the Hospital Anxiety and Depression Scale, Multidimensional Scale of Perceived Social Support, Montreal Cognitive Assessment, Pittsburgh Sleep Quality Index, and Zarit Burden Interview. The medical factors were assessed using laboratory examinations. Correlation and canonical correlation analyses were performed to investigate the association patterns. The QoL was significantly correlated with the psychosocial factors, and to a lesser extent with the medical factors. The medical and psychosocial factors were also correlated. The canonical correlation analysis indicated a correlation between QoL and psychosocial factors (1st canonical correlation = 0.696, P psychosocial factors were also correlated (1st canonical correlation = 0.689, P Psychosocial factors influence QoL in patients with ESRD, and should thus be carefully considered when caring for these patients in clinical practice. © 2018 The Korean Academy of Medical Sciences.

Analysis of input variables of an artificial neural network using bivariate correlation and canonical correlation

International Nuclear Information System (INIS)

Costa, Valter Magalhaes

2011-01-01

The monitoring of variables and diagnosis of sensor fault in nuclear power plants or processes industries is very important because an early diagnosis allows the correction of the fault and, like this, do not cause the production interruption, improving operator's security and it's not provoking economics losses. The objective of this work is, in the whole of all variables monitor of a nuclear power plant, to build a set, not necessary minimum, which will be the set of input variables of an artificial neural network and, like way, to monitor the biggest number of variables. This methodology was applied to the IEA-R1 Research Reactor at IPEN. For this, the variables Power, Rate of flow of primary circuit, Rod of control/security and Difference in pressure in the core of the reactor ( Δ P) was grouped, because, for hypothesis, almost whole of monitoring variables have relation with the variables early described or its effect can be result of the interaction of two or more. The Power is related to the increasing and decreasing of temperatures as well as the amount radiation due fission of the uranium; the Rods are controls of power and influence in the amount of radiation and increasing and decreasing of temperatures and the Rate of flow of primary circuit has function of the transport of energy by removing of heat of the nucleus Like this, labeling B= {Power, Rate of flow of Primary Circuit, Rod of Control/Security and Δ P} was computed the correlation between B and all another variables monitoring (coefficient of multiple correlation), that is, by the computer of the multiple correlation, that is tool of Theory of Canonical Correlations, was possible to computer how much the set B can predict each variable. Due the impossibility of a satisfactory approximation by B in the prediction of some variables, it was included one or more variables that have high correlation with this variable to improve the quality of prediction. In this work an artificial neural network

Oblique rotaton in canonical correlation analysis reformulated as maximizing the generalized coefficient of determination.

Science.gov (United States)

Satomura, Hironori; Adachi, Kohei

2013-07-01

To facilitate the interpretation of canonical correlation analysis (CCA) solutions, procedures have been proposed in which CCA solutions are orthogonally rotated to a simple structure. In this paper, we consider oblique rotation for CCA to provide solutions that are much easier to interpret, though only orthogonal rotation is allowed in the existing formulations of CCA. Our task is thus to reformulate CCA so that its solutions have the freedom of oblique rotation. Such a task can be achieved using Yanai's (Jpn. J. Behaviormetrics 1:46-54, 1974; J. Jpn. Stat. Soc. 11:43-53, 1981) generalized coefficient of determination for the objective function to be maximized in CCA. The resulting solutions are proved to include the existing orthogonal ones as special cases and to be rotated obliquely without affecting the objective function value, where ten Berge's (Psychometrika 48:519-523, 1983) theorems on suborthonormal matrices are used. A real data example demonstrates that the proposed oblique rotation can provide simple, easily interpreted CCA solutions.

Data-driven fault detection for industrial processes canonical correlation analysis and projection based methods

CERN Document Server

Chen, Zhiwen

2017-01-01

Zhiwen Chen aims to develop advanced fault detection (FD) methods for the monitoring of industrial processes. With the ever increasing demands on reliability and safety in industrial processes, fault detection has become an important issue. Although the model-based fault detection theory has been well studied in the past decades, its applications are limited to large-scale industrial processes because it is difficult to build accurate models. Furthermore, motivated by the limitations of existing data-driven FD methods, novel canonical correlation analysis (CCA) and projection-based methods are proposed from the perspectives of process input and output data, less engineering effort and wide application scope. For performance evaluation of FD methods, a new index is also developed. Contents A New Index for Performance Evaluation of FD Methods CCA-based FD Method for the Monitoring of Stationary Processes Projection-based FD Method for the Monitoring of Dynamic Processes Benchmark Study and Real-Time Implementat...

Real-Time EEG Signal Enhancement Using Canonical Correlation Analysis and Gaussian Mixture Clustering

Directory of Open Access Journals (Sweden)

Chin-Teng Lin

2018-01-01

Full Text Available Electroencephalogram (EEG signals are usually contaminated with various artifacts, such as signal associated with muscle activity, eye movement, and body motion, which have a noncerebral origin. The amplitude of such artifacts is larger than that of the electrical activity of the brain, so they mask the cortical signals of interest, resulting in biased analysis and interpretation. Several blind source separation methods have been developed to remove artifacts from the EEG recordings. However, the iterative process for measuring separation within multichannel recordings is computationally intractable. Moreover, manually excluding the artifact components requires a time-consuming offline process. This work proposes a real-time artifact removal algorithm that is based on canonical correlation analysis (CCA, feature extraction, and the Gaussian mixture model (GMM to improve the quality of EEG signals. The CCA was used to decompose EEG signals into components followed by feature extraction to extract representative features and GMM to cluster these features into groups to recognize and remove artifacts. The feasibility of the proposed algorithm was demonstrated by effectively removing artifacts caused by blinks, head/body movement, and chewing from EEG recordings while preserving the temporal and spectral characteristics of the signals that are important to cognitive research.

Association Study between Lead and Zinc Accumulation at Different Physiological Systems of Cattle by Canonical Correlation and Canonical Correspondence Analyses

Science.gov (United States)

Karmakar, Partha; Das, Pradip Kumar; Mondal, Seema Sarkar; Karmakar, Sougata; Mazumdar, Debasis

2010-10-01

Pb pollution from automobile exhausts around highways is a persistent problem in India. Pb intoxication in mammalian body is a complex phenomenon which is influence by agonistic and antagonistic interactions of several other heavy metals and micronutrients. An attempt has been made to study the association between Pb and Zn accumulation in different physiological systems of cattles (n = 200) by application of both canonical correlation and canonical correspondence analyses. Pb was estimated from plasma, liver, bone, muscle, kidney, blood and milk where as Zn was measured from all these systems except bone, blood and milk. Both statistical techniques demonstrated that there was a strong association among blood-Pb, liver-Zn, kidney-Zn and muscle-Zn. From observations, it can be assumed that Zn accumulation in cattles' muscle, liver and kidney directs Pb mobilization from those organs which in turn increases Pb pool in blood. It indicates antagonistic activity of Zn to the accumulation of Pb. Although there were some contradictions between the observations obtained from the two different statistical methods, the overall pattern of Pb accumulation in various organs as influenced by Zn were same. It is mainly due to the fact that canonical correlation is actually a special type of canonical correspondence analyses where linear relationship is followed between two groups of variables instead of Gaussian relationship.

Association Study between Lead and Zinc Accumulation at Different Physiological Systems of Cattle by Canonical Correlation and Canonical Correspondence Analyses

International Nuclear Information System (INIS)

Karmakar, Partha; Das, Pradip Kumar; Mondal, Seema Sarkar; Karmakar, Sougata; Mazumdar, Debasis

2010-01-01

Pb pollution from automobile exhausts around highways is a persistent problem in India. Pb intoxication in mammalian body is a complex phenomenon which is influence by agonistic and antagonistic interactions of several other heavy metals and micronutrients. An attempt has been made to study the association between Pb and Zn accumulation in different physiological systems of cattles (n = 200) by application of both canonical correlation and canonical correspondence analyses. Pb was estimated from plasma, liver, bone, muscle, kidney, blood and milk where as Zn was measured from all these systems except bone, blood and milk. Both statistical techniques demonstrated that there was a strong association among blood-Pb, liver-Zn, kidney-Zn and muscle-Zn. From observations, it can be assumed that Zn accumulation in cattles' muscle, liver and kidney directs Pb mobilization from those organs which in turn increases Pb pool in blood. It indicates antagonistic activity of Zn to the accumulation of Pb. Although there were some contradictions between the observations obtained from the two different statistical methods, the overall pattern of Pb accumulation in various organs as influenced by Zn were same. It is mainly due to the fact that canonical correlation is actually a special type of canonical correspondence analyses where linear relationship is followed between two groups of variables instead of Gaussian relationship.

Clinical Trials With Large Numbers of Variables: Important Advantages of Canonical Analysis.

Science.gov (United States)

Cleophas, Ton J

2016-01-01

Canonical analysis assesses the combined effects of a set of predictor variables on a set of outcome variables, but it is little used in clinical trials despite the omnipresence of multiple variables. The aim of this study was to assess the performance of canonical analysis as compared with traditional multivariate methods using multivariate analysis of covariance (MANCOVA). As an example, a simulated data file with 12 gene expression levels and 4 drug efficacy scores was used. The correlation coefficient between the 12 predictor and 4 outcome variables was 0.87 (P = 0.0001) meaning that 76% of the variability in the outcome variables was explained by the 12 covariates. Repeated testing after the removal of 5 unimportant predictor and 1 outcome variable produced virtually the same overall result. The MANCOVA identified identical unimportant variables, but it was unable to provide overall statistics. (1) Canonical analysis is remarkable, because it can handle many more variables than traditional multivariate methods such as MANCOVA can. (2) At the same time, it accounts for the relative importance of the separate variables, their interactions and differences in units. (3) Canonical analysis provides overall statistics of the effects of sets of variables, whereas traditional multivariate methods only provide the statistics of the separate variables. (4) Unlike other methods for combining the effects of multiple variables such as factor analysis/partial least squares, canonical analysis is scientifically entirely rigorous. (5) Limitations include that it is less flexible than factor analysis/partial least squares, because only 2 sets of variables are used and because multiple solutions instead of one is offered. We do hope that this article will stimulate clinical investigators to start using this remarkable method.

3D spatially-adaptive canonical correlation analysis: Local and global methods.

Science.gov (United States)

Yang, Zhengshi; Zhuang, Xiaowei; Sreenivasan, Karthik; Mishra, Virendra; Curran, Tim; Byrd, Richard; Nandy, Rajesh; Cordes, Dietmar

2018-04-01

Local spatially-adaptive canonical correlation analysis (local CCA) with spatial constraints has been introduced to fMRI multivariate analysis for improved modeling of activation patterns. However, current algorithms require complicated spatial constraints that have only been applied to 2D local neighborhoods because the computational time would be exponentially increased if the same method is applied to 3D spatial neighborhoods. In this study, an efficient and accurate line search sequential quadratic programming (SQP) algorithm has been developed to efficiently solve the 3D local CCA problem with spatial constraints. In addition, a spatially-adaptive kernel CCA (KCCA) method is proposed to increase accuracy of fMRI activation maps. With oriented 3D spatial filters anisotropic shapes can be estimated during the KCCA analysis of fMRI time courses. These filters are orientation-adaptive leading to rotational invariance to better match arbitrary oriented fMRI activation patterns, resulting in improved sensitivity of activation detection while significantly reducing spatial blurring artifacts. The kernel method in its basic form does not require any spatial constraints and analyzes the whole-brain fMRI time series to construct an activation map. Finally, we have developed a penalized kernel CCA model that involves spatial low-pass filter constraints to increase the specificity of the method. The kernel CCA methods are compared with the standard univariate method and with two different local CCA methods that were solved by the SQP algorithm. Results show that SQP is the most efficient algorithm to solve the local constrained CCA problem, and the proposed kernel CCA methods outperformed univariate and local CCA methods in detecting activations for both simulated and real fMRI episodic memory data. Copyright © 2017 Elsevier Inc. All rights reserved.

The Smoothing Artifact of Spatially Constrained Canonical Correlation Analysis in Functional MRI

Directory of Open Access Journals (Sweden)

Dietmar Cordes

2012-01-01

Full Text Available A wide range of studies show the capacity of multivariate statistical methods for fMRI to improve mapping of brain activations in a noisy environment. An advanced method uses local canonical correlation analysis (CCA to encompass a group of neighboring voxels instead of looking at the single voxel time course. The value of a suitable test statistic is used as a measure of activation. It is customary to assign the value to the center voxel; however, this is a choice of convenience and without constraints introduces artifacts, especially in regions of strong localized activation. To compensate for these deficiencies, different spatial constraints in CCA have been introduced to enforce dominance of the center voxel. However, even if the dominance condition for the center voxel is satisfied, constrained CCA can still lead to a smoothing artifact, often called the “bleeding artifact of CCA”, in fMRI activation patterns. In this paper a new method is introduced to measure and correct for the smoothing artifact for constrained CCA methods. It is shown that constrained CCA methods corrected for the smoothing artifact lead to more plausible activation patterns in fMRI as shown using data from a motor task and a memory task.

Canonical correlation analysis of factors involved in the occurrence of peptic ulcers.

Science.gov (United States)

Bayyurt, Nizamettin; Abasiyanik, M Fatih; Sander, Ersan; Salih, Barik A

2007-01-01

The impact of risk factors on the development of peptic ulcers has been shown to vary among different populations. We sought to establish a correlation between these factors and their involvement in the occurrence of peptic ulcers for which a canonical correlation analysis was applied. We included 7,014 patient records (48.6% women, 18.4% duodenal ulcer [DU], 4.6% gastric ulcer [GU]) of those underwent upper gastroendoscopy for the last 5 years. The variables measured are endoscopic findings (DU, GU, antral gastritis, erosive gastritis, pangastritis, pyloric deformity, bulbar deformity, bleeding, atrophy, Barret esophagus and gastric polyp) and risk factors (age, gender, Helicobacter pylori infection, smoking, alcohol, and nonsteroidal anti-inflammatory drugs [NSAIDs] and aspirin intake). We found that DU had significant positive correlation with bulbar deformity (P=2.6 x 10(-23)), pyloric deformity (P=2.6 x 10(-23)), gender (P=2.6 x 10(-23)), H. pylori (P=1.4 x 10(-15)), bleeding (P=6.9 x 10(-15)), smoking (P=1.4 x 10(-7)), aspirin use (P=1.1 x 10(-4)), alcohol intake (P=7.7 x 10(-4)), and NSAIDs (P=.01). GU had a significantly positive correlation with pyloric deformity (P=1,6 x 10(-15)), age (P=2.6 x 10(-14)), bleeding (P=3.7 x 10(-8)), gender (P=1.3 x 10(-7)), aspirin use (P=1.1 x 10(-6)), bulbar deformity (P=7.4 x 10(-4)), alcohol intake (P=.03), smoking (P=.04), and Barret esophagus (P=.03). The level of significance was much higher in some variables with DU than with GU and the correlations with GU in spite of being highly significant the majority, were small in magnitude. In conclusion, Turkish patients with the following endoscopic findings bulbar deformity and pyloric deformity are high-risk patients for peptic ulcers with the risk of the occurrence of DU being higher than that of GU. Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU

A Unified Approach to Functional Principal Component Analysis and Functional Multiple-Set Canonical Correlation.

Science.gov (United States)

Choi, Ji Yeh; Hwang, Heungsun; Yamamoto, Michio; Jung, Kwanghee; Woodward, Todd S

2017-06-01

Functional principal component analysis (FPCA) and functional multiple-set canonical correlation analysis (FMCCA) are data reduction techniques for functional data that are collected in the form of smooth curves or functions over a continuum such as time or space. In FPCA, low-dimensional components are extracted from a single functional dataset such that they explain the most variance of the dataset, whereas in FMCCA, low-dimensional components are obtained from each of multiple functional datasets in such a way that the associations among the components are maximized across the different sets. In this paper, we propose a unified approach to FPCA and FMCCA. The proposed approach subsumes both techniques as special cases. Furthermore, it permits a compromise between the techniques, such that components are obtained from each set of functional data to maximize their associations across different datasets, while accounting for the variance of the data well. We propose a single optimization criterion for the proposed approach, and develop an alternating regularized least squares algorithm to minimize the criterion in combination with basis function approximations to functions. We conduct a simulation study to investigate the performance of the proposed approach based on synthetic data. We also apply the approach for the analysis of multiple-subject functional magnetic resonance imaging data to obtain low-dimensional components of blood-oxygen level-dependent signal changes of the brain over time, which are highly correlated across the subjects as well as representative of the data. The extracted components are used to identify networks of neural activity that are commonly activated across the subjects while carrying out a working memory task.

metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis.

Science.gov (United States)

Cichonska, Anna; Rousu, Juho; Marttinen, Pekka; Kangas, Antti J; Soininen, Pasi; Lehtimäki, Terho; Raitakari, Olli T; Järvelin, Marjo-Riitta; Salomaa, Veikko; Ala-Korpela, Mika; Ripatti, Samuli; Pirinen, Matti

2016-07-01

A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex associations become detectable only when several variants are tested jointly. Currently, modest sample sizes of individual cohorts, and restricted availability of individual-level genotype-phenotype data across the cohorts limit conducting multivariate tests. We introduce metaCCA, a computational framework for summary statistics-based analysis of a single or multiple studies that allows multivariate representation of both genotype and phenotype. It extends the statistical technique of canonical correlation analysis to the setting where original individual-level records are not available, and employs a covariance shrinkage algorithm to achieve robustness.Multivariate meta-analysis of two Finnish studies of nuclear magnetic resonance metabolomics by metaCCA, using standard univariate output from the program SNPTEST, shows an excellent agreement with the pooled individual-level analysis of original data. Motivated by strong multivariate signals in the lipid genes tested, we envision that multivariate association testing using metaCCA has a great potential to provide novel insights from already published summary statistics from high-throughput phenotyping technologies. Code is available at https://github.com/aalto-ics-kepaco anna.cichonska@helsinki.fi or matti.pirinen@helsinki.fi Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

A quadratically regularized functional canonical correlation analysis for identifying the global structure of pleiotropy with NGS data.

Science.gov (United States)

Lin, Nan; Zhu, Yun; Fan, Ruzong; Xiong, Momiao

2017-10-01

Investigating the pleiotropic effects of genetic variants can increase statistical power, provide important information to achieve deep understanding of the complex genetic structures of disease, and offer powerful tools for designing effective treatments with fewer side effects. However, the current multiple phenotype association analysis paradigm lacks breadth (number of phenotypes and genetic variants jointly analyzed at the same time) and depth (hierarchical structure of phenotype and genotypes). A key issue for high dimensional pleiotropic analysis is to effectively extract informative internal representation and features from high dimensional genotype and phenotype data. To explore correlation information of genetic variants, effectively reduce data dimensions, and overcome critical barriers in advancing the development of novel statistical methods and computational algorithms for genetic pleiotropic analysis, we proposed a new statistic method referred to as a quadratically regularized functional CCA (QRFCCA) for association analysis which combines three approaches: (1) quadratically regularized matrix factorization, (2) functional data analysis and (3) canonical correlation analysis (CCA). Large-scale simulations show that the QRFCCA has a much higher power than that of the ten competing statistics while retaining the appropriate type 1 errors. To further evaluate performance, the QRFCCA and ten other statistics are applied to the whole genome sequencing dataset from the TwinsUK study. We identify a total of 79 genes with rare variants and 67 genes with common variants significantly associated with the 46 traits using QRFCCA. The results show that the QRFCCA substantially outperforms the ten other statistics.

Multiview Bayesian Correlated Component Analysis

DEFF Research Database (Denmark)

Kamronn, Simon Due; Poulsen, Andreas Trier; Hansen, Lars Kai

2015-01-01

are identical. Here we propose a hierarchical probabilistic model that can infer the level of universality in such multiview data, from completely unrelated representations, corresponding to canonical correlation analysis, to identical representations as in correlated component analysis. This new model, which...... we denote Bayesian correlated component analysis, evaluates favorably against three relevant algorithms in simulated data. A well-established benchmark EEG data set is used to further validate the new model and infer the variability of spatial representations across multiple subjects....

Structured and Sparse Canonical Correlation Analysis as a Brain-Wide Multi-Modal Data Fusion Approach.

Science.gov (United States)

Mohammadi-Nejad, Ali-Reza; Hossein-Zadeh, Gholam-Ali; Soltanian-Zadeh, Hamid

2017-07-01

Multi-modal data fusion has recently emerged as a comprehensive neuroimaging analysis approach, which usually uses canonical correlation analysis (CCA). However, the current CCA-based fusion approaches face problems like high-dimensionality, multi-collinearity, unimodal feature selection, asymmetry, and loss of spatial information in reshaping the imaging data into vectors. This paper proposes a structured and sparse CCA (ssCCA) technique as a novel CCA method to overcome the above problems. To investigate the performance of the proposed algorithm, we have compared three data fusion techniques: standard CCA, regularized CCA, and ssCCA, and evaluated their ability to detect multi-modal data associations. We have used simulations to compare the performance of these approaches and probe the effects of non-negativity constraint, the dimensionality of features, sample size, and noise power. The results demonstrate that ssCCA outperforms the existing standard and regularized CCA-based fusion approaches. We have also applied the methods to real functional magnetic resonance imaging (fMRI) and structural MRI data of Alzheimer's disease (AD) patients (n = 34) and healthy control (HC) subjects (n = 42) from the ADNI database. The results illustrate that the proposed unsupervised technique differentiates the transition pattern between the subject-course of AD patients and HC subjects with a p-value of less than 1×10 -6 . Furthermore, we have depicted the brain mapping of functional areas that are most correlated with the anatomical changes in AD patients relative to HC subjects.

Combination of canonical correlation analysis and empirical mode decomposition applied to denoising the labor electrohysterogram.

Science.gov (United States)

Hassan, Mahmoud; Boudaoud, Sofiane; Terrien, Jérémy; Karlsson, Brynjar; Marque, Catherine

2011-09-01

The electrohysterogram (EHG) is often corrupted by electronic and electromagnetic noise as well as movement artifacts, skeletal electromyogram, and ECGs from both mother and fetus. The interfering signals are sporadic and/or have spectra overlapping the spectra of the signals of interest rendering classical filtering ineffective. In the absence of efficient methods for denoising the monopolar EHG signal, bipolar methods are usually used. In this paper, we propose a novel combination of blind source separation using canonical correlation analysis (BSS_CCA) and empirical mode decomposition (EMD) methods to denoise monopolar EHG. We first extract the uterine bursts by using BSS_CCA then the biggest part of any residual noise is removed from the bursts by EMD. Our algorithm, called CCA_EMD, was compared with wavelet filtering and independent component analysis. We also compared CCA_EMD with the corresponding bipolar signals to demonstrate that the new method gives signals that have not been degraded by the new method. The proposed method successfully removed artifacts from the signal without altering the underlying uterine activity as observed by bipolar methods. The CCA_EMD algorithm performed considerably better than the comparison methods.

Extending Local Canonical Correlation Analysis to Handle General Linear Contrasts for fMRI Data

Directory of Open Access Journals (Sweden)

Mingwu Jin

2012-01-01

Full Text Available Local canonical correlation analysis (CCA is a multivariate method that has been proposed to more accurately determine activation patterns in fMRI data. In its conventional formulation, CCA has several drawbacks that limit its usefulness in fMRI. A major drawback is that, unlike the general linear model (GLM, a test of general linear contrasts of the temporal regressors has not been incorporated into the CCA formalism. To overcome this drawback, a novel directional test statistic was derived using the equivalence of multivariate multiple regression (MVMR and CCA. This extension will allow CCA to be used for inference of general linear contrasts in more complicated fMRI designs without reparameterization of the design matrix and without reestimating the CCA solutions for each particular contrast of interest. With the proper constraints on the spatial coefficients of CCA, this test statistic can yield a more powerful test on the inference of evoked brain regional activations from noisy fMRI data than the conventional t-test in the GLM. The quantitative results from simulated and pseudoreal data and activation maps from fMRI data were used to demonstrate the advantage of this novel test statistic.

Human health implications of extreme precipitation events and water quality in California, USA: a canonical correlation analysis

Directory of Open Access Journals (Sweden)

Alexander Gershunov, PhD

2018-05-01

Full Text Available Background: Pathogens and pollutants collect on the land surface or in infrastructure between strong rainfall episodes and are delivered via storm runoff to areas of human exposure, such as coastal recreational waters. In California, USA, precipitation events are projected to become more extreme and simultaneously decrease in frequency as storm tracks move poleward due to polar-amplified global warming. Precipitation extremes in California are dominated by atmospheric rivers, which carry more moisture in warmer climates. Thus, the physical driver of extreme precipitation events is expected to grow stronger with climate change, and pollutant accumulation and runoff-generated exposure to those pollutants are expected to increase, particularly after prolonged dry spells. Microbiological contamination of coastal waters during winter storms exposes human populations to elevated concentrations of microorganisms such as faecal bacteria, which could cause gastrointestinal and ear infections, and lead to exposure to pathogens causing life-threatening conditions, such as hepatitis A. The aim of this study was to quantitatively assess the effect of precipitation on coastal water quality in California. Methods: We used a recently published catalogue of atmospheric rivers, in combination with historical daily precipitation data and levels of three indicators of faecal bacteria (total and faecal coliforms, and Escherichia coli detected at roughly 500 monitoring locations in coastal waters along California's 840-mile coastline, to explore weekly associations between extreme precipitation events, particularly those related to atmospheric rivers, and the variability in water quality during 2003–09. We identified ten principal components (together explaining >90% of the variability in precipitation and faecal bacteria time-series to reduce the dimensionality of the datasets. We then performed canonical correlation analysis of the principal components to

A new randomized Kaczmarz based kernel canonical correlation analysis algorithm with applications to information retrieval.

Science.gov (United States)

Cai, Jia; Tang, Yi

2018-02-01

Canonical correlation analysis (CCA) is a powerful statistical tool for detecting the linear relationship between two sets of multivariate variables. Kernel generalization of it, namely, kernel CCA is proposed to describe nonlinear relationship between two variables. Although kernel CCA can achieve dimensionality reduction results for high-dimensional data feature selection problem, it also yields the so called over-fitting phenomenon. In this paper, we consider a new kernel CCA algorithm via randomized Kaczmarz method. The main contributions of the paper are: (1) A new kernel CCA algorithm is developed, (2) theoretical convergence of the proposed algorithm is addressed by means of scaled condition number, (3) a lower bound which addresses the minimum number of iterations is presented. We test on both synthetic dataset and several real-world datasets in cross-language document retrieval and content-based image retrieval to demonstrate the effectiveness of the proposed algorithm. Numerical results imply the performance and efficiency of the new algorithm, which is competitive with several state-of-the-art kernel CCA methods. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Use of Canonical Correlation Analysis to Assess the Relationship Between Executive Functioning and Verbal Memory in Older Adults

Directory of Open Access Journals (Sweden)

Pedro Silva Moreira MSc

2015-08-01

Full Text Available Executive functioning (EF, which is considered to govern complex cognition, and verbal memory (VM are constructs assumed to be related. However, it is not known the magnitude of the association between EF and VM, and how sociodemographic and psychological factors may affect this relationship, including in normal aging. In this study, we assessed different EF and VM parameters, via a battery of neurocognitive/psychological tests, and performed a Canonical Correlation Analysis (CCA to explore the connection between these constructs, in a sample of middle-aged and older healthy individuals without cognitive impairment ( N = 563, 50+ years of age. The analysis revealed a positive and moderate association between EF and VM independently of gender, age, education, global cognitive performance level, and mood. These results confirm that EF presents a significant association with VM performance.

Removal of eye blink artifacts in wireless EEG sensor networks using reduced-bandwidth canonical correlation analysis.

Science.gov (United States)

Somers, Ben; Bertrand, Alexander

2016-12-01

Chronic, 24/7 EEG monitoring requires the use of highly miniaturized EEG modules, which only measure a few EEG channels over a small area. For improved spatial coverage, a wireless EEG sensor network (WESN) can be deployed, consisting of multiple EEG modules, which interact through short-distance wireless communication. In this paper, we aim to remove eye blink artifacts in each EEG channel of a WESN by optimally exploiting the correlation between EEG signals from different modules, under stringent communication bandwidth constraints. We apply a distributed canonical correlation analysis (CCA-)based algorithm, in which each module only transmits an optimal linear combination of its local EEG channels to the other modules. The method is validated on both synthetic and real EEG data sets, with emulated wireless transmissions. While strongly reducing the amount of data that is shared between nodes, we demonstrate that the algorithm achieves the same eye blink artifact removal performance as the equivalent centralized CCA algorithm, which is at least as good as other state-of-the-art multi-channel algorithms that require a transmission of all channels. Due to their potential for extreme miniaturization, WESNs are viewed as an enabling technology for chronic EEG monitoring. However, multi-channel analysis is hampered in WESNs due to the high energy cost for wireless communication. This paper shows that multi-channel eye blink artifact removal is possible with a significantly reduced wireless communication between EEG modules.

Identification of associations between genotypes and longitudinal phenotypes via temporally-constrained group sparse canonical correlation analysis.

Science.gov (United States)

Hao, Xiaoke; Li, Chanxiu; Yan, Jingwen; Yao, Xiaohui; Risacher, Shannon L; Saykin, Andrew J; Shen, Li; Zhang, Daoqiang

2017-07-15

Neuroimaging genetics identifies the relationships between genetic variants (i.e., the single nucleotide polymorphisms) and brain imaging data to reveal the associations from genotypes to phenotypes. So far, most existing machine-learning approaches are widely used to detect the effective associations between genetic variants and brain imaging data at one time-point. However, those associations are based on static phenotypes and ignore the temporal dynamics of the phenotypical changes. The phenotypes across multiple time-points may exhibit temporal patterns that can be used to facilitate the understanding of the degenerative process. In this article, we propose a novel temporally constrained group sparse canonical correlation analysis (TGSCCA) framework to identify genetic associations with longitudinal phenotypic markers. The proposed TGSCCA method is able to capture the temporal changes in brain from longitudinal phenotypes by incorporating the fused penalty, which requires that the differences between two consecutive canonical weight vectors from adjacent time-points should be small. A new efficient optimization algorithm is designed to solve the objective function. Furthermore, we demonstrate the effectiveness of our algorithm on both synthetic and real data (i.e., the Alzheimer's Disease Neuroimaging Initiative cohort, including progressive mild cognitive impairment, stable MCI and Normal Control participants). In comparison with conventional SCCA, our proposed method can achieve strong associations and discover phenotypic biomarkers across multiple time-points to guide disease-progressive interpretation. The Matlab code is available at https://sourceforge.net/projects/ibrain-cn/files/ . dqzhang@nuaa.edu.cn or shenli@iu.edu. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Canonical analysis based on mutual information

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Vestergaard, Jacob Schack

2015-01-01

combinations with the information theoretical measure mutual information (MI). We term this type of analysis canonical information analysis (CIA). MI allows for the actual joint distribution of the variables involved and not just second order statistics. While CCA is ideal for Gaussian data, CIA facilitates...

Extension of Kirkwood-Buff theory to the canonical ensemble

Science.gov (United States)

Rogers, David M.

2018-02-01

Kirkwood-Buff (KB) integrals are notoriously difficult to converge from a canonical simulation because they require estimating the grand-canonical radial distribution. The same essential difficulty is encountered when attempting to estimate the direct correlation function of Ornstein-Zernike theory by inverting the pair correlation functions. We present a new theory that applies to the entire, finite, simulation volume, so that no cutoff issues arise at all. The theory gives the direct correlation function for closed systems, while smoothness of the direct correlation function in reciprocal space allows calculating canonical KB integrals via a well-posed extrapolation to the origin. The present analysis method represents an improvement over previous work because it makes use of the entire simulation volume and its convergence can be accelerated using known properties of the direct correlation function. Using known interaction energy functions can make this extrapolation near perfect accuracy in the low-density case. Because finite size effects are stronger in the canonical than in the grand-canonical ensemble, we state ensemble correction formulas for the chemical potential and the KB coefficients. The new theory is illustrated with both analytical and simulation results on the 1D Ising model and a supercritical Lennard-Jones fluid. For the latter, the finite-size corrections are shown to be small.

Extracting drug mechanism and pharmacodynamic information from clinical electroencephalographic data using generalised semi-linear canonical correlation analysis

International Nuclear Information System (INIS)

Brain, P; Strimenopoulou, F; Ivarsson, M; Wilson, F J; Diukova, A; Wise, R G; Berry, E; Jolly, A; Hall, J E

2014-01-01

Conventional analysis of clinical resting electroencephalography (EEG) recordings typically involves assessment of spectral power in pre-defined frequency bands at specific electrodes. EEG is a potentially useful technique in drug development for measuring the pharmacodynamic (PD) effects of a centrally acting compound and hence to assess the likelihood of success of a novel drug based on pharmacokinetic–pharmacodynamic (PK–PD) principles. However, the need to define the electrodes and spectral bands to be analysed a priori is limiting where the nature of the drug-induced EEG effects is initially not known. We describe the extension to human EEG data of a generalised semi-linear canonical correlation analysis (GSLCCA), developed for small animal data. GSLCCA uses data from the whole spectrum, the entire recording duration and multiple electrodes. It provides interpretable information on the mechanism of drug action and a PD measure suitable for use in PK–PD modelling. Data from a study with low (analgesic) doses of the μ-opioid agonist, remifentanil, in 12 healthy subjects were analysed using conventional spectral edge analysis and GSLCCA. At this low dose, the conventional analysis was unsuccessful but plausible results consistent with previous observations were obtained using GSLCCA, confirming that GSLCCA can be successfully applied to clinical EEG data. (paper)

Canonical variate regression.

Science.gov (United States)

Luo, Chongliang; Liu, Jin; Dey, Dipak K; Chen, Kun

2016-07-01

In many fields, multi-view datasets, measuring multiple distinct but interrelated sets of characteristics on the same set of subjects, together with data on certain outcomes or phenotypes, are routinely collected. The objective in such a problem is often two-fold: both to explore the association structures of multiple sets of measurements and to develop a parsimonious model for predicting the future outcomes. We study a unified canonical variate regression framework to tackle the two problems simultaneously. The proposed criterion integrates multiple canonical correlation analysis with predictive modeling, balancing between the association strength of the canonical variates and their joint predictive power on the outcomes. Moreover, the proposed criterion seeks multiple sets of canonical variates simultaneously to enable the examination of their joint effects on the outcomes, and is able to handle multivariate and non-Gaussian outcomes. An efficient algorithm based on variable splitting and Lagrangian multipliers is proposed. Simulation studies show the superior performance of the proposed approach. We demonstrate the effectiveness of the proposed approach in an [Formula: see text] intercross mice study and an alcohol dependence study. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Decoding the auditory brain with canonical component analysis.

Science.gov (United States)

de Cheveigné, Alain; Wong, Daniel D E; Di Liberto, Giovanni M; Hjortkjær, Jens; Slaney, Malcolm; Lalor, Edmund

2018-05-15

The relation between a stimulus and the evoked brain response can shed light on perceptual processes within the brain. Signals derived from this relation can also be harnessed to control external devices for Brain Computer Interface (BCI) applications. While the classic event-related potential (ERP) is appropriate for isolated stimuli, more sophisticated "decoding" strategies are needed to address continuous stimuli such as speech, music or environmental sounds. Here we describe an approach based on Canonical Correlation Analysis (CCA) that finds the optimal transform to apply to both the stimulus and the response to reveal correlations between the two. Compared to prior methods based on forward or backward models for stimulus-response mapping, CCA finds significantly higher correlation scores, thus providing increased sensitivity to relatively small effects, and supports classifier schemes that yield higher classification scores. CCA strips the brain response of variance unrelated to the stimulus, and the stimulus representation of variance that does not affect the response, and thus improves observations of the relation between stimulus and response. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Linear and Nonlinear Multiset Canonical Correlation Analysis (invited talk)

DEFF Research Database (Denmark)

Hilger, Klaus Baggesen; Nielsen, Allan Aasbjerg; Larsen, Rasmus

2002-01-01

This paper deals with decompositioning of multiset data. Friedman's alternating conditional expectations (ACE) algorithm is extended to handle multiple sets of variables of different mixtures. The new algorithm finds estimates of the optimal transformations of the involved variables that maximize...... the sum of the pair-wise correlations over all sets. The new algorithm is termed multi-set ACE (MACE) and can find multiple orthogonal eigensolutions. MACE is a generalization of the linear multiset correlations analysis (MCCA). It handles multivariate multisets of arbitrary mixtures of both continuous...

[Job stress of nursing aides in Swiss nursing homes : Nonlinear canonical analysis].

Science.gov (United States)

Ziegler, A; Bernet, M; Metzenthin, P; Conca, A; Hahn, S

2016-08-01

Due to demographic changes, the demand for care in nursing homes for the elderly and infirmed is growing. At the same time nursing staff shortages are also increasing. Nursing aides are the primary care providers and comprise the largest staff group in Swiss nursing homes. They are exposed to various forms of job stress, which threaten job retention. The aim of this study was to discover which features of the work situation and which personal characteristics of the nursing aides were related to the workload. Data from nursing aides in Swiss nursing homes were investigated through a secondary analysis of a national quantitative cross-sectional study, using descriptive statistics and a nonlinear canonical correlation analysis. A total of 1054 nursing aides were included in the secondary analysis, 94.6 % of whom were women between the ages of 42 and 61 years. The job stress most frequently mentioned in the descriptive analysis, almost 60 % of the participants referred to it, was staff shortage. The nonlinear canonical correlation analysis revealed that many job strains are caused by social and organizational issues. In particular, a lack of support from supervisors was associated with staff not feeling appreciated. These job strains correlated with a high level of responsibility, the feeling of being unable to work independently and a feeling of being exploited. These strains were predominant in the nursing aides between 32 and 51 years old who had part time jobs but workloads of 80-90 %. Middle-aged nursing aides who worked to 80-90 % are particularly at risk to resign from the position prematurely. Measures need to be mainly implemented in the social and organizational areas. It can be assumed that a targeted individual support, recognition and promotion of nursing aides may decrease the level of job strain.

Canonical correlation analysis between collaborative networks and innovation: A case study in information technology companies in province of Tehran, Iran

Directory of Open Access Journals (Sweden)

Ahmad Jafar Nejad

2013-07-01

Full Text Available The increase competitions as well as technological advancements have created motivation among business owners to look for more innovative ideas from outside their organizations. Many enterprises collaborate with other organizations to empower themselves through innovative ideas. These kinds of collaborations can be observed as a concept called Regional Innovation System. These collaborations include inter-firm collaborations, research organizations, intermediary institutions and governmental agencies. The primary objective of this paper is to evaluate relationships between Collaborative Networks and Innovation in information technology business units located in province of Tehran, Iran. The research method utilized for the present study is descriptive-correlation. To evaluate the relationships between independent and dependent variables, canonical correlation analysis (CCA is used. The results confirm the previous findings regarding the relationship between Collaborative Networks and Innovation. Among various dimensions of Collaboration, Collaboration with governmental agencies had a very small impact on the relationship between collaboration networks and innovation. In addition, the results show that in addition to affecting product innovation and process innovation, collaboration networks also affected management innovation.

Unsupervised detection and removal of muscle artifacts from scalp EEG recordings using canonical correlation analysis, wavelets and random forests.

Science.gov (United States)

Anastasiadou, Maria N; Christodoulakis, Manolis; Papathanasiou, Eleftherios S; Papacostas, Savvas S; Mitsis, Georgios D

2017-09-01

This paper proposes supervised and unsupervised algorithms for automatic muscle artifact detection and removal from long-term EEG recordings, which combine canonical correlation analysis (CCA) and wavelets with random forests (RF). The proposed algorithms first perform CCA and continuous wavelet transform of the canonical components to generate a number of features which include component autocorrelation values and wavelet coefficient magnitude values. A subset of the most important features is subsequently selected using RF and labelled observations (supervised case) or synthetic data constructed from the original observations (unsupervised case). The proposed algorithms are evaluated using realistic simulation data as well as 30min epochs of non-invasive EEG recordings obtained from ten patients with epilepsy. We assessed the performance of the proposed algorithms using classification performance and goodness-of-fit values for noisy and noise-free signal windows. In the simulation study, where the ground truth was known, the proposed algorithms yielded almost perfect performance. In the case of experimental data, where expert marking was performed, the results suggest that both the supervised and unsupervised algorithm versions were able to remove artifacts without affecting noise-free channels considerably, outperforming standard CCA, independent component analysis (ICA) and Lagged Auto-Mutual Information Clustering (LAMIC). The proposed algorithms achieved excellent performance for both simulation and experimental data. Importantly, for the first time to our knowledge, we were able to perform entirely unsupervised artifact removal, i.e. without using already marked noisy data segments, achieving performance that is comparable to the supervised case. Overall, the results suggest that the proposed algorithms yield significant future potential for improving EEG signal quality in research or clinical settings without the need for marking by expert

Canonical analysis of non-relativistic particle and superparticle

Energy Technology Data Exchange (ETDEWEB)

Kluson, Josef [Masaryk University, Department of Theoretical Physics and Astrophysics, Faculty of Science, Brno (Czech Republic)

2018-02-15

We perform canonical analysis of non-relativistic particle in Newton-Cartan Background. Then we extend this analysis to the case of non-relativistic superparticle in the same background. We determine constraints structure of this theory and find generator of κ-symmetry. (orig.)

Sequence detection analysis based on canonical correlation for steady-state visual evoked potential brain computer interfaces.

Science.gov (United States)

Cao, Lei; Ju, Zhengyu; Li, Jie; Jian, Rongjun; Jiang, Changjun

2015-09-30

Steady-state visual evoked potential (SSVEP) has been widely applied to develop brain computer interface (BCI) systems. The essence of SSVEP recognition is to recognize the frequency component of target stimulus focused by a subject significantly present in EEG spectrum. In this paper, a novel statistical approach based on sequence detection (SD) is proposed for improving the performance of SSVEP recognition. This method uses canonical correlation analysis (CCA) coefficients to observe SSVEP signal sequence. And then, a threshold strategy is utilized for SSVEP recognition. The result showed the classification performance with the longer duration of time window achieved the higher accuracy for most subjects. And the average time costing per trial was lower than the predefined recognition time. It was implicated that our approach could improve the speed of BCI system in contrast to other methods. Comparison with existing method(s): In comparison with other resultful algorithms, experimental accuracy of SD approach was better than those using a widely used CCA-based method and two newly proposed algorithms, least absolute shrinkage and selection operator (LASSO) recognition model as well as multivariate synchronization index (MSI) method. Furthermore, the information transfer rate (ITR) obtained by SD approach was higher than those using other three methods for most participants. These conclusions demonstrated that our proposed method was promising for a high-speed online BCI. Copyright © 2015 Elsevier B.V. All rights reserved.

Generalized Canonical Time Warping.

Science.gov (United States)

Zhou, Feng; De la Torre, Fernando

2016-02-01

Temporal alignment of human motion has been of recent interest due to its applications in animation, tele-rehabilitation and activity recognition. This paper presents generalized canonical time warping (GCTW), an extension of dynamic time warping (DTW) and canonical correlation analysis (CCA) for temporally aligning multi-modal sequences from multiple subjects performing similar activities. GCTW extends previous work on DTW and CCA in several ways: (1) it combines CCA with DTW to align multi-modal data (e.g., video and motion capture data); (2) it extends DTW by using a linear combination of monotonic functions to represent the warping path, providing a more flexible temporal warp. Unlike exact DTW, which has quadratic complexity, we propose a linear time algorithm to minimize GCTW. (3) GCTW allows simultaneous alignment of multiple sequences. Experimental results on aligning multi-modal data, facial expressions, motion capture data and video illustrate the benefits of GCTW. The code is available at http://humansensing.cs.cmu.edu/ctw.

Relations between canonical and non-canonical inflation

Energy Technology Data Exchange (ETDEWEB)

Gwyn, Rhiannon [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut), Potsdam (Germany); Rummel, Markus [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Westphal, Alexander [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Theory Group

2012-12-15

We look for potential observational degeneracies between canonical and non-canonical models of inflation of a single field {phi}. Non-canonical inflationary models are characterized by higher than linear powers of the standard kinetic term X in the effective Lagrangian p(X,{phi}) and arise for instance in the context of the Dirac-Born-Infeld (DBI) action in string theory. An on-shell transformation is introduced that transforms non-canonical inflationary theories to theories with a canonical kinetic term. The 2-point function observables of the original non-canonical theory and its canonical transform are found to match in the case of DBI inflation.

Change detection in bi-temporal data by canonical information analysis

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Vestergaard, Jacob Schack

2015-01-01

combinations with the information theoretical measure mutual information (MI). We term this type of analysis canonical information analysis (CIA). MI allows for the actual joint distribution of the variables involved and not just second order statistics. Where CCA is ideal for Gaussian data, CIA facilitates...

Correlation of iris biometrics and DNA

DEFF Research Database (Denmark)

Harder, Stine; Clemmensen, Line Katrine Harder; Dahl, Anders Bjorholm

2013-01-01

The presented work concerns prediction of complex human phenotypes from genotypes. We were interested in correlating iris color and texture with DNA. Our data consist of 212 eye images along with DNA: 32 single-nucleotide polymorphisms (SNPs). We used two types of biometrics to describe the eye...... images: One for iris color and one for iris texture. Both biometrics were high dimensional and a sparse principle component analysis (SPCA) reduced the dimensions and resulted in a representation of data with good interpretability. The correlations between the sparse principal components (SPCs......) and the 32 SNPs were found using a canonical correlation analysis (CCA). The result was a single significant canonical correlation (CC) for both biometrics. Each CC comprised two correlated canonical variables, consisting of a linear combination of SPCs and a linear combination of SNPs, respectively...

Testing the significance of canonical axes in redundancy analysis

NARCIS (Netherlands)

Legendre, P.; Oksanen, J.; Braak, ter C.J.F.

2011-01-01

1. Tests of significance of the individual canonical axes in redundancy analysis allow researchers to determine which of the axes represent variation that can be distinguished from random. Variation along the significant axes can be mapped, used to draw biplots or interpreted through subsequent

Convergence analysis of canonical genetic algorithms.

Science.gov (United States)

Rudolph, G

1994-01-01

This paper analyzes the convergence properties of the canonical genetic algorithm (CGA) with mutation, crossover and proportional reproduction applied to static optimization problems. It is proved by means of homogeneous finite Markov chain analysis that a CGA will never converge to the global optimum regardless of the initialization, crossover, operator and objective function. But variants of CGA's that always maintain the best solution in the population, either before or after selection, are shown to converge to the global optimum due to the irreducibility property of the underlying original nonconvergent CGA. These results are discussed with respect to the schema theorem.

A canonical approach to forces in molecules

Energy Technology Data Exchange (ETDEWEB)

Walton, Jay R. [Department of Mathematics, Texas A& M University, College Station, TX 77843-3368 (United States); Rivera-Rivera, Luis A., E-mail: rivera@chem.tamu.edu [Department of Chemistry, Texas A& M University, College Station, TX 77843-3255 (United States); Lucchese, Robert R.; Bevan, John W. [Department of Chemistry, Texas A& M University, College Station, TX 77843-3255 (United States)

2016-08-02

Highlights: • Derivation of canonical representation of molecular force. • Correlation of derivations with accurate results from Born–Oppenheimer potentials. • Extension of methodology to Mg{sub 2}, benzene dimer, and water dimer. - Abstract: In previous studies, we introduced a generalized formulation for canonical transformations and spectra to investigate the concept of canonical potentials strictly within the Born–Oppenheimer approximation. Data for the most accurate available ground electronic state pairwise intramolecular potentials in H{sub 2}{sup +}, H{sub 2}, HeH{sup +}, and LiH were used to rigorously establish such conclusions. Now, a canonical transformation is derived for the molecular force, F(R), with H{sub 2}{sup +} as molecular reference. These transformations are demonstrated to be inherently canonical to high accuracy but distinctly different from those corresponding to the respective potentials of H{sub 2}, HeH{sup +}, and LiH. In this paper, we establish the canonical nature of the molecular force which is key to fundamental generalization of canonical approaches to molecular bonding. As further examples Mg{sub 2}, benzene dimer and to water dimer are also considered within the radial limit as applications of the current methodology.

Canonical Analysis Technique as an Approach to Determine Optimal Conditions for Lactic Acid Production by Lactobacillus helveticus ATCC 15009

Directory of Open Access Journals (Sweden)

Marcelo Teixeira Leite

2012-01-01

Full Text Available The response surface methodology and canonical analysis were employed to find the most suitable conditions for Lactobacillus helveticus to produce lactic acid from cheese whey in batch fermentation. The analyzed variables were temperature, pH, and the concentrations of lactose and yeast extract. The experiments were carried out according to a central composite design with three center points. An empiric equation that correlated the concentration of lactic acid with the independent variables was proposed. The optimal conditions determined by the canonical analysis of the fitted model were 40°C, pH 6.8, 82 g/L of lactose, and 23.36 g/L of yeast extract. At this point, the lactic acid concentration reached 59.38 g/L. A subsequent fermentation, carried out under optimal conditions, confirmed the product concentration predicted by the adjusted model. This concentration of lactic acid is the highest ever reported for Lactobacillus helveticus ATCC 15009 in batch process using cheese whey as substrate.

Defining the Relationship of Student Achievement Between STEM Subjects Through Canonical Correlation Analysis of 2011 Trends in International Mathematics and Science Study (TIMSS) Data

Science.gov (United States)

O'Neal, Melissa Jean

Canonical correlation analysis was used to analyze data from Trends in International Mathematics and Science Study (TIMSS) 2011 achievement databases encompassing information from fourth/eighth grades. Student achievement in life science/biology was correlated with achievement in mathematics and other sciences across three analytical areas: mathematics and science student performance, achievement in cognitive domains, and achievement in content domains. Strong correlations between student achievement in life science/biology with achievement in mathematics and overall science occurred for both high- and low-performing education systems. Hence, partial emphases on the inter-subject connections did not always lead to a better student learning outcome in STEM education. In addition, student achievement in life science/biology was positively correlated with achievement in mathematics and science cognitive domains; these patterns held true for correlations of life science/biology with mathematics as well as other sciences. The importance of linking student learning experiences between and within STEM domains to support high performance on TIMSS assessments was indicated by correlations of moderate strength (57 TIMSS assessments was indicated by correlations of moderate strength (57 mathematics, and other sciences. At the eighth grade level, students who built increasing levels of cognitive complexity upon firm foundations were prepared for successful learning throughout their educational careers. The results from this investigation promote a holistic design of school learning opportunities to improve student achievement in life science/biology and other science, technology, engineering, and mathematics (STEM) subjects at the elementary and middle school levels. While the curriculum can vary from combined STEM subjects to separated mathematics or science courses, both professional learning communities (PLC) for teachers and problem-based learning (PBL) for learners can be

Insight into dynamic genome imaging: Canonical framework identification and high-throughput analysis.

Science.gov (United States)

Ronquist, Scott; Meixner, Walter; Rajapakse, Indika; Snyder, John

2017-07-01

The human genome is dynamic in structure, complicating researcher's attempts at fully understanding it. Time series "Fluorescent in situ Hybridization" (FISH) imaging has increased our ability to observe genome structure, but due to cell type and experimental variability this data is often noisy and difficult to analyze. Furthermore, computational analysis techniques are needed for homolog discrimination and canonical framework detection, in the case of time-series images. In this paper we introduce novel ideas for nucleus imaging analysis, present findings extracted using dynamic genome imaging, and propose an objective algorithm for high-throughput, time-series FISH imaging. While a canonical framework could not be detected beyond statistical significance in the analyzed dataset, a mathematical framework for detection has been outlined with extension to 3D image analysis. Copyright © 2017 Elsevier Inc. All rights reserved.

The canonical and grand canonical models for nuclear ...

Indian Academy of Sciences (India)

Many observables seen in intermediate energy heavy-ion collisions can be explained on the basis of statistical equilibrium. Calculations based on statistical equilibrium can be implemented in microcanonical ensemble, canonical ensemble or grand canonical ensemble. This paper deals with calculations with canonical ...

Canonical Correlational Models of Students’ Perceptions of Assessment Tasks, Motivational Orientations, and Learning Strategies

Directory of Open Access Journals (Sweden)

Hussain Alkharusi

2013-01-01

Full Text Available The present study aims at deriving correlational models of students' perceptions of assessment tasks, motivational orientations, and learning strategies using canonical analyses. Data were collected from 198 Omani tenth grade students. Results showed that high degrees of authenticity and transparency in assessment were associated with positive students' self-efficacy and task value. Also, high degrees of authenticity, transparency, and diversity in assessment were associated with a strong reliance on deep learning strategies; whereas a high degree of congruence with planned learning and a low degree of authenticity were associated with more reliance on surface learning strategies. Implications for classroom assessment practice and research were discussed.

Correlações canônicas de características agroindustriais em cana-deaçúcar = Canonical correlations of agro-industrial characteristics in sugarcane

Directory of Open Access Journals (Sweden)

José Wilson da Silva

2007-07-01

Full Text Available A análise de correlações canônicas mede a existência e a intensidade da associação entre dois grupos de variáveis ou caracteres de importância. Este trabalho teve como objetivo estimar a intensidade de associação entre os grupos de caracteres agronômicos e industriais em cana-de-açúcar. Pela análise de correlações canônicas, ficouevidenciado que clones com maior número de touceiras por parcela e maior número de colmos por touceira tendem a proporcionar um aumento na produção de cana (TCH, e para incrementar o rendimento de TCH, brix e a pol% devem ser selecionados clones baixos, com maior diâmetro, maior número de colmos por touceiras.The analysis of canonical correlations measures the existence and the intensity of the association between two groups of variables or characters of importance. This study aimed to estimate the intensity in the association between the agronomic and industrial characters in sugarcane. The analysis of canonic correlations allowed to conclude that clones with bigger number of stalks per parcel, greater number of stalks per stool tend to provide an increase in the TCH production. Another conclusion was that shorter clones with largerdiameter, greater number of stalks per stool and plants, are determinant in increasing TCH, brix and pol% characteristics.

Symmetric minimally entangled typical thermal states for canonical and grand-canonical ensembles

Science.gov (United States)

Binder, Moritz; Barthel, Thomas

2017-05-01

Based on the density matrix renormalization group (DMRG), strongly correlated quantum many-body systems at finite temperatures can be simulated by sampling over a certain class of pure matrix product states (MPS) called minimally entangled typical thermal states (METTS). When a system features symmetries, these can be utilized to substantially reduce MPS computation costs. It is conceptually straightforward to simulate canonical ensembles using symmetric METTS. In practice, it is important to alternate between different symmetric collapse bases to decrease autocorrelations in the Markov chain of METTS. To this purpose, we introduce symmetric Fourier and Haar-random block bases that are efficiently mixing. We also show how grand-canonical ensembles can be simulated efficiently with symmetric METTS. We demonstrate these approaches for spin-1 /2 X X Z chains and discuss how the choice of the collapse bases influences autocorrelations as well as the distribution of measurement values and, hence, convergence speeds.

A hybrid correlation analysis with application to imaging genetics

Science.gov (United States)

Hu, Wenxing; Fang, Jian; Calhoun, Vince D.; Wang, Yu-Ping

2018-03-01

Investigating the association between brain regions and genes continues to be a challenging topic in imaging genetics. Current brain region of interest (ROI)-gene association studies normally reduce data dimension by averaging the value of voxels in each ROI. This averaging may lead to a loss of information due to the existence of functional sub-regions. Pearson correlation is widely used for association analysis. However, it only detects linear correlation whereas nonlinear correlation may exist among ROIs. In this work, we introduced distance correlation to ROI-gene association analysis, which can detect both linear and nonlinear correlations and overcome the limitation of averaging operations by taking advantage of the information at each voxel. Nevertheless, distance correlation usually has a much lower value than Pearson correlation. To address this problem, we proposed a hybrid correlation analysis approach, by applying canonical correlation analysis (CCA) to the distance covariance matrix instead of directly computing distance correlation. Incorporating CCA into distance correlation approach may be more suitable for complex disease study because it can detect highly associated pairs of ROI and gene groups, and may improve the distance correlation level and statistical power. In addition, we developed a novel nonlinear CCA, called distance kernel CCA, which seeks the optimal combination of features with the most significant dependence. This approach was applied to imaging genetic data from the Philadelphia Neurodevelopmental Cohort (PNC). Experiments showed that our hybrid approach produced more consistent results than conventional CCA across resampling and both the correlation and statistical significance were increased compared to distance correlation analysis. Further gene enrichment analysis and region of interest (ROI) analysis confirmed the associations of the identified genes with brain ROIs. Therefore, our approach provides a powerful tool for finding

Bitcoin Market Volatility Analysis Using Grand Canonical Minority Game

Directory of Open Access Journals (Sweden)

Matteo Ortisi

2016-12-01

Full Text Available In this paper we propose to use the Grand Canonical Minority Game (GCMG, a highly simplified financial market model as a model of bitcoin market to show how the lack of an income for “miners”, similar to yield earned by bond holders, could be a structural reason for high volatility of bitcoin price in a reference currency. Coherently with present analysis, the introduction of future contracts on bitcoin would have the effect of reducing the overall market volatility.

Noether analysis of the twisted Hopf symmetries of canonical noncommutative spacetimes

International Nuclear Information System (INIS)

Amelino-Camelia, Giovanni; Gubitosi, Giulia; Marciano, Antonino; Martinetti, Pierre; Mercati, Flavio; Briscese, Fabio

2008-01-01

We study the twisted Hopf-algebra symmetries of observer-independent canonical spacetime noncommutativity, for which the commutators of the spacetime coordinates take the form [x^ μ ,x^ ν ]=iθ μν with observer-independent (and coordinate-independent) θ μν . We find that it is necessary to introduce nontrivial commutators between transformation parameters and spacetime coordinates, and that the form of these commutators implies that all symmetry transformations must include a translation component. We show that with our noncommutative transformation parameters the Noether analysis of the symmetries is straightforward, and we compare our canonical-noncommutativity results with the structure of the conserved charges and the ''no-pure-boost'' requirement derived in a previous study of κ-Minkowski noncommutativity. We also verify that, while at intermediate stages of the analysis we do find terms that depend on the ordering convention adopted in setting up the Weyl map, the final result for the conserved charges is reassuringly independent of the choice of Weyl map and (the corresponding choice of) star product.

Sparse canonical methods for biological data integration: application to a cross-platform study

Directory of Open Access Journals (Sweden)

Robert-Granié Christèle

2009-01-01

Full Text Available Abstract Background In the context of systems biology, few sparse approaches have been proposed so far to integrate several data sets. It is however an important and fundamental issue that will be widely encountered in post genomic studies, when simultaneously analyzing transcriptomics, proteomics and metabolomics data using different platforms, so as to understand the mutual interactions between the different data sets. In this high dimensional setting, variable selection is crucial to give interpretable results. We focus on a sparse Partial Least Squares approach (sPLS to handle two-block data sets, where the relationship between the two types of variables is known to be symmetric. Sparse PLS has been developed either for a regression or a canonical correlation framework and includes a built-in procedure to select variables while integrating data. To illustrate the canonical mode approach, we analyzed the NCI60 data sets, where two different platforms (cDNA and Affymetrix chips were used to study the transcriptome of sixty cancer cell lines. Results We compare the results obtained with two other sparse or related canonical correlation approaches: CCA with Elastic Net penalization (CCA-EN and Co-Inertia Analysis (CIA. The latter does not include a built-in procedure for variable selection and requires a two-step analysis. We stress the lack of statistical criteria to evaluate canonical correlation methods, which makes biological interpretation absolutely necessary to compare the different gene selections. We also propose comprehensive graphical representations of both samples and variables to facilitate the interpretation of the results. Conclusion sPLS and CCA-EN selected highly relevant genes and complementary findings from the two data sets, which enabled a detailed understanding of the molecular characteristics of several groups of cell lines. These two approaches were found to bring similar results, although they highlighted the same

Canonical integration and analysis of periodic maps using non-standard analysis and life methods

Energy Technology Data Exchange (ETDEWEB)

Forest, E.; Berz, M.

1988-06-01

We describe a method and a way of thinking which is ideally suited for the study of systems represented by canonical integrators. Starting with the continuous description provided by the Hamiltonians, we replace it by a succession of preferably canonical maps. The power series representation of these maps can be extracted with a computer implementation of the tools of Non-Standard Analysis and analyzed by the same tools. For a nearly integrable system, we can define a Floquet ring in a way consistent with our needs. Using the finite time maps, the Floquet ring is defined only at the locations s/sub i/ where one perturbs or observes the phase space. At most the total number of locations is equal to the total number of steps of our integrator. We can also produce pseudo-Hamiltonians which describe the motion induced by these maps. 15 refs., 1 fig.

Fan fiction, early Greece, and the historicity of canon

Directory of Open Access Journals (Sweden)

Ahuvia Kahane

2016-03-01

Full Text Available The historicity of canon is considered with an emphasis on contemporary fan fiction and early Greek oral epic traditions. The essay explores the idea of canon by highlighting historical variance, exposing wider conceptual isomorphisms, and formulating a revised notion of canonicity. Based on an analysis of canon in early Greece, the discussion moves away from the idea of canon as a set of valued works and toward canon as a practice of containment in response to inherent states of surplus. This view of canon is applied to the practice of fan fiction, reestablishing the idea of canonicity in fluid production environments within a revised, historically specific understanding in early oral traditions on the one hand and in digital cultures and fan fiction on the other. Several examples of early epigraphic Greek texts embedded in oral environments are analyzed and assessed in terms of their implications for an understanding of fan fiction and its modern contexts.

Removal of the ballistocardiographic artifact from EEG-fMRI data: a canonical correlation approach

International Nuclear Information System (INIS)

Assecondi, Sara; Hallez, Hans; Staelens, Steven; Lemahieu, Ignace; Bianchi, Anna M; Huiskamp, Geertjan M

2009-01-01

The simultaneous recording of electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) can give new insights into how the brain functions. However, the strong electromagnetic field of the MR scanner generates artifacts that obscure the EEG and diminish its readability. Among them, the ballistocardiographic artifact (BCGa) that appears on the EEG is believed to be related to blood flow in scalp arteries leading to electrode movements. Average artifact subtraction (AAS) techniques, used to remove the BCGa, assume a deterministic nature of the artifact. This assumption may be too strong, considering the blood flow related nature of the phenomenon. In this work we propose a new method, based on canonical correlation analysis (CCA) and blind source separation (BSS) techniques, to reduce the BCGa from simultaneously recorded EEG-fMRI. We optimized the method to reduce the user's interaction to a minimum. When tested on six subjects, recorded in 1.5 T or 3 T, the average artifact extracted with BSS-CCA and AAS did not show significant differences, proving the absence of systematic errors. On the other hand, when compared on the basis of intra-subject variability, we found significant differences and better performance of the proposed method with respect to AAS. We demonstrated that our method deals with the intrinsic subject variability specific to the artifact that may cause averaging techniques to fail.

Combined approach based on principal component analysis and canonical discriminant analysis for investigating hyperspectral plant response

Directory of Open Access Journals (Sweden)

Anna Maria Stellacci

2012-07-01

Full Text Available Hyperspectral (HS data represents an extremely powerful means for rapidly detecting crop stress and then aiding in the rational management of natural resources in agriculture. However, large volume of data poses a challenge for data processing and extracting crucial information. Multivariate statistical techniques can play a key role in the analysis of HS data, as they may allow to both eliminate redundant information and identify synthetic indices which maximize differences among levels of stress. In this paper we propose an integrated approach, based on the combined use of Principal Component Analysis (PCA and Canonical Discriminant Analysis (CDA, to investigate HS plant response and discriminate plant status. The approach was preliminary evaluated on a data set collected on durum wheat plants grown under different nitrogen (N stress levels. Hyperspectral measurements were performed at anthesis through a high resolution field spectroradiometer, ASD FieldSpec HandHeld, covering the 325-1075 nm region. Reflectance data were first restricted to the interval 510-1000 nm and then divided into five bands of the electromagnetic spectrum [green: 510-580 nm; yellow: 581-630 nm; red: 631-690 nm; red-edge: 705-770 nm; near-infrared (NIR: 771-1000 nm]. PCA was applied to each spectral interval. CDA was performed on the extracted components to identify the factors maximizing the differences among plants fertilised with increasing N rates. Within the intervals of green, yellow and red only the first principal component (PC had an eigenvalue greater than 1 and explained more than 95% of total variance; within the ranges of red-edge and NIR, the first two PCs had an eigenvalue higher than 1. Two canonical variables explained cumulatively more than 81% of total variance and the first was able to discriminate wheat plants differently fertilised, as confirmed also by the significant correlation with aboveground biomass and grain yield parameters. The combined

A model of individualized canonical microcircuits supporting cognitive operations.

Directory of Open Access Journals (Sweden)

Tim Kunze

Full Text Available Major cognitive functions such as language, memory, and decision-making are thought to rely on distributed networks of a large number of basic elements, called canonical microcircuits. In this theoretical study we propose a novel canonical microcircuit model and find that it supports two basic computational operations: a gating mechanism and working memory. By means of bifurcation analysis we systematically investigate the dynamical behavior of the canonical microcircuit with respect to parameters that govern the local network balance, that is, the relationship between excitation and inhibition, and key intrinsic feedback architectures of canonical microcircuits. We relate the local behavior of the canonical microcircuit to cognitive processing and demonstrate how a network of interacting canonical microcircuits enables the establishment of spatiotemporal sequences in the context of syntax parsing during sentence comprehension. This study provides a framework for using individualized canonical microcircuits for the construction of biologically realistic networks supporting cognitive operations.

El canon literario peruano

Directory of Open Access Journals (Sweden)

Carlos García-Bedoya Maguiña

2011-05-01

Full Text Available Canon es un concepto clave en la historia literaria. En el presente artículo,se revisa la evolución histórica del canon literario peruano. Es solo con la llamada República Aristocrática, en las primeras décadas del siglo XX, que cabe hablar en el caso peruano de la formación de un auténtico canon nacional. El autor denomina a esta primera versión del canon literario peruano como canon oligárquico y destaca la importancia de la obra de Riva Agüero y de Ventura García Calderón en su configuración. Es solo más tarde, desde los años 20 y de modo definitivo desde los años 50, que puede hablarse de la emergencia de un nuevo canon literarioal que el autor propone determinar canon posoligárquico.

Whose Canon? Culturalization versus Democratization

Directory of Open Access Journals (Sweden)

Erling Bjurström

2012-06-01

Full Text Available Current accounts – and particularly the critique – of canon formation are primarily based on some form of identity politics. In the 20th century a representational model of social identities replaced cultivation as the primary means to democratize the canons of the fine arts. In a parallel development, the discourse on canons has shifted its focus from processes of inclusion to those of exclusion. This shift corresponds, on the one hand, to the construction of so-called alternative canons or counter-canons, and, on the other hand, to attempts to restore the authority of canons considered to be in a state of crisis or decaying. Regardless of the democratic stance of these efforts, the construction of alternatives or the reestablishment of decaying canons does not seem to achieve their aims, since they break with the explicit and implicit rules of canon formation. Politically motivated attempts to revise or restore a specific canon make the workings of canon formation too visible, transparent and calculated, thereby breaking the spell of its imaginary character. Retracing the history of the canonization of the fine arts reveals that it was originally tied to the disembedding of artists and artworks from social and worldly affairs, whereas debates about canons of the fine arts since the end of the 20th century are heavily dependent on their social, cultural and historical reembedding. The latter has the character of disenchantment, but has also fettered the canon debate in notions of “our” versus “their” culture. However, by emphasizing the dedifferentiation of contemporary processes of culturalization, the advancing canonization of popular culture seems to be able to break with identity politics that foster notions of “our” culture in the present thinking on canons, and push it in a more transgressive, syncretic or hybrid direction.

Modern Canonical Quantum General Relativity

Science.gov (United States)

Thiemann, Thomas

2008-11-01

Preface; Notation and conventions; Introduction; Part I. Classical Foundations, Interpretation and the Canonical Quantisation Programme: 1. Classical Hamiltonian formulation of general relativity; 2. The problem of time, locality and the interpretation of quantum mechanics; 3. The programme of canonical quantisation; 4. The new canonical variables of Ashtekar for general relativity; Part II. Foundations of Modern Canonical Quantum General Relativity: 5. Introduction; 6. Step I: the holonomy-flux algebra [P]; 7. Step II: quantum-algebra; 8. Step III: representation theory of [A]; 9. Step IV: 1. Implementation and solution of the kinematical constraints; 10. Step V: 2. Implementation and solution of the Hamiltonian constraint; 11. Step VI: semiclassical analysis; Part III. Physical Applications: 12. Extension to standard matter; 13. Kinematical geometrical operators; 14. Spin foam models; 15. Quantum black hole physics; 16. Applications to particle physics and quantum cosmology; 17. Loop quantum gravity phenomenology; Part IV. Mathematical Tools and their Connection to Physics: 18. Tools from general topology; 19. Differential, Riemannian, symplectic and complex geometry; 20. Semianalytical category; 21. Elements of fibre bundle theory; 22. Holonomies on non-trivial fibre bundles; 23. Geometric quantisation; 24. The Dirac algorithm for field theories with constraints; 25. Tools from measure theory; 26. Elementary introduction to Gel'fand theory for Abelean C* algebras; 27. Bohr compactification of the real line; 28. Operatir -algebras and spectral theorem; 29. Refined algebraic quantisation (RAQ) and direct integral decomposition (DID); 30. Basics of harmonic analysis on compact Lie groups; 31. Spin network functions for SU(2); 32. + Functional analytical description of classical connection dynamics; Bibliography; Index.

Generalización del método de correlaciones canónicas aplicado a un problema de economía (Generalization of the canonical correlation method applied to an economy problem

Directory of Open Access Journals (Sweden)

Jorge Luis Azor Hernández

2018-03-01

Full Text Available Resumen. El Análisis de Correlaciones Canónicas (CCA desarrollado por Hotelling entre 1935 y 1936 es un método utilizado para estudiar las relaciones existentes entre dos conjuntos de variables. En 1968 Carroll introdujo una generalización de este método que permite analizar simultáneamente más de dos conjuntos de datos. Otra extensión de CCA es el Análisis de Correlaciones Canónicas Funcional que estudia las relaciones entre dos conjuntos de variables cuando estas transcurren en el tiempo. En este artículo se analiza, mediante estos métodos, la relación entre las ventas y el número de empleados en un problema de la economía mexicana English abstract. Canonical Correlation Analysis (CCA developed by Hotelling between 1935 and 1936 is a method used to study the relationships between two sets of variables. In 1968 Carroll introduced a generalization of this method to simultaneously analyze more than two datasets. Another extension of CCA is Functional Canonical Correlation Analysis that studies the relationships between two sets of variables when they pass in time. In this article, the relationship between sales and the number of employees in a problem of the Mexican economy is analyzed through these methods.

The dark sector from interacting canonical and non-canonical scalar fields

International Nuclear Information System (INIS)

De Souza, Rudinei C; Kremer, Gilberto M

2010-01-01

In this work general models with interactions between two canonical scalar fields and between one non-canonical (tachyon type) and one canonical scalar field are investigated. The potentials and couplings to the gravity are selected through the Noether symmetry approach. These general models are employed to describe interactions between dark energy and dark matter, with the fields being constrained by the astronomical data. The cosmological solutions of some cases are compared with the observed evolution of the late Universe.

Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres.

Directory of Open Access Journals (Sweden)

Alexander M Many

Full Text Available The characterization of mammary stem cells, and signals that regulate their behavior, is of central importance in understanding developmental changes in the mammary gland and possibly for targeting stem-like cells in breast cancer. The canonical Wnt/β-catenin pathway is a signaling mechanism associated with maintenance of self-renewing stem cells in many tissues, including mammary epithelium, and can be oncogenic when deregulated. Wnt1 and Wnt3a are examples of ligands that activate the canonical pathway. Other Wnt ligands, such as Wnt5a, typically signal via non-canonical, β-catenin-independent, pathways that in some cases can antagonize canonical signaling. Since the role of non-canonical Wnt signaling in stem cell regulation is not well characterized, we set out to investigate this using mammosphere formation assays that reflect and quantify stem cell properties. Ex vivo mammosphere cultures were established from both wild-type and Wnt1 transgenic mice and were analyzed in response to manipulation of both canonical and non-canonical Wnt signaling. An increased level of mammosphere formation was observed in cultures derived from MMTV-Wnt1 versus wild-type animals, and this was blocked by treatment with Dkk1, a selective inhibitor of canonical Wnt signaling. Consistent with this, we found that a single dose of recombinant Wnt3a was sufficient to increase mammosphere formation in wild-type cultures. Surprisingly, we found that Wnt5a also increased mammosphere formation in these assays. We confirmed that this was not caused by an increase in canonical Wnt/β-catenin signaling but was instead mediated by non-canonical Wnt signals requiring the receptor tyrosine kinase Ror2 and activity of the Jun N-terminal kinase, JNK. We conclude that both canonical and non-canonical Wnt signals have positive effects promoting stem cell activity in mammosphere assays and that they do so via independent signaling mechanisms.

Measurements of the Canonical Helicity Evolution of a Gyrating Kinked Flux Rope

Science.gov (United States)

von der Linden, J.; Sears, J.; Intrator, T.; You, S.

2017-12-01

Magnetic structures in the solar corona and planetary magnetospheres are often modelled as magnetic flux ropes governed by magnetohydrodynamics (MHD); however, inside these structures, as exhibited in reconnection, conversions between magnetic and kinetic energies occur over a wide range of scales. Flux ropes based on the flux of canonical momentum circulation extend the flux rope concept to include effects of finite particle momentum and present the distinct advantage of reconciling all plasma regimes - e.g. kinetic, two-fluid, and MHD - with the topological concept of helicity: twists, writhes, and linkages. This presentation shows the first visualization and analysis of the 3D dynamics of canonical flux ropes and their relative helicity evolution from laboratory measurements. Ion and electron canonical flux ropes are visualized from a dataset of Mach, triple, and Ḃ probe measurements at over 10,000 spatial locations of a gyrating kinked flux rope. The flux ropes co-gyrate with the peak density and electron temperature in and out of a measurement volume. The electron and ion canonical flux ropes twist with opposite handedness and the ion flux ropes writhe around the electron flux ropes. The relative cross helicity between the magnetic and ion flow vorticity flux ropes dominates the relative ion canonical helicity and is anti-correlated with the relative magnetic helicity. The 3D nature of the kink and a reverse eddy current affect the helicity evolution. This work is supported by DOE Grant DE-SC0010340 and the DOE Office of Science Graduate Student Research Program and prepared in part by LLNL under Contract DE-AC52-07NA27344. LLNL-ABS-735426

Three dimensional canonical transformations

International Nuclear Information System (INIS)

Tegmen, A.

2010-01-01

A generic construction of canonical transformations is given in three-dimensional phase spaces on which Nambu bracket is imposed. First, the canonical transformations are defined as based on cannonade transformations. Second, it is shown that determination of the generating functions and the transformation itself for given generating function is possible by solving correspondent Pfaffian differential equations. Generating functions of type are introduced and all of them are listed. Infinitesimal canonical transformations are also discussed as the complementary subject. Finally, it is shown that decomposition of canonical transformations is also possible in three-dimensional phase spaces as in the usual two-dimensional ones.

Statistical hadronization and hadronic micro-canonical ensemble II

International Nuclear Information System (INIS)

Becattini, F.; Ferroni, L.

2004-01-01

We present a Monte Carlo calculation of the micro-canonical ensemble of the ideal hadron-resonance gas including all known states up to a mass of about 1.8 GeV and full quantum statistics. The micro-canonical average multiplicities of the various hadron species are found to converge to the canonical ones for moderately low values of the total energy, around 8 GeV, thus bearing out previous analyses of hadronic multiplicities in the canonical ensemble. The main numerical computing method is an importance sampling Monte Carlo algorithm using the product of Poisson distributions to generate multi-hadronic channels. It is shown that the use of this multi-Poisson distribution allows for an efficient and fast computation of averages, which can be further improved in the limit of very large clusters. We have also studied the fitness of a previously proposed computing method, based on the Metropolis Monte Carlo algorithm, for event generation in the statistical hadronization model. We find that the use of the multi-Poisson distribution as proposal matrix dramatically improves the computation performance. However, due to the correlation of subsequent samples, this method proves to be generally less robust and effective than the importance sampling method. (orig.)

Canonical methods in classical and quantum gravity: An invitation to canonical LQG

Science.gov (United States)

Reyes, Juan D.

2018-04-01

Loop Quantum Gravity (LQG) is a candidate quantum theory of gravity still under construction. LQG was originally conceived as a background independent canonical quantization of Einstein’s general relativity theory. This contribution provides some physical motivations and an overview of some mathematical tools employed in canonical Loop Quantum Gravity. First, Hamiltonian classical methods are reviewed from a geometric perspective. Canonical Dirac quantization of general gauge systems is sketched next. The Hamiltonian formultation of gravity in geometric ADM and connection-triad variables is then presented to finally lay down the canonical loop quantization program. The presentation is geared toward advanced undergradute or graduate students in physics and/or non-specialists curious about LQG.

Grand canonical simulations of hard-disk systems by simulated tempering

DEFF Research Database (Denmark)

Döge, G.; Mecke, K.; Møller, Jesper

2004-01-01

The melting transition of hard disks in two dimensions is still an unsolved problem and improved simulation algorithms may be helpful for its investigation. We suggest the application of simulating tempering for grand canonical hard-disk systems as an efficient alternative to the commonly......-used Monte Carlo algorithms for canonical systems. This approach allows the direct study of the packing fraction as a function of the chemical potential even in the vicinity of the melting transition. Furthermore, estimates of several spatial characteristics including pair correlation function are studied...

Quantum canonical ensemble: A projection operator approach

Science.gov (United States)

Magnus, Wim; Lemmens, Lucien; Brosens, Fons

2017-09-01

Knowing the exact number of particles N, and taking this knowledge into account, the quantum canonical ensemble imposes a constraint on the occupation number operators. The constraint particularly hampers the systematic calculation of the partition function and any relevant thermodynamic expectation value for arbitrary but fixed N. On the other hand, fixing only the average number of particles, one may remove the above constraint and simply factorize the traces in Fock space into traces over single-particle states. As is well known, that would be the strategy of the grand-canonical ensemble which, however, comes with an additional Lagrange multiplier to impose the average number of particles. The appearance of this multiplier can be avoided by invoking a projection operator that enables a constraint-free computation of the partition function and its derived quantities in the canonical ensemble, at the price of an angular or contour integration. Introduced in the recent past to handle various issues related to particle-number projected statistics, the projection operator approach proves beneficial to a wide variety of problems in condensed matter physics for which the canonical ensemble offers a natural and appropriate environment. In this light, we present a systematic treatment of the canonical ensemble that embeds the projection operator into the formalism of second quantization while explicitly fixing N, the very number of particles rather than the average. Being applicable to both bosonic and fermionic systems in arbitrary dimensions, transparent integral representations are provided for the partition function ZN and the Helmholtz free energy FN as well as for two- and four-point correlation functions. The chemical potential is not a Lagrange multiplier regulating the average particle number but can be extracted from FN+1 -FN, as illustrated for a two-dimensional fermion gas.

Canonical transformations of Kepler trajectories

International Nuclear Information System (INIS)

Mostowski, Jan

2010-01-01

In this paper, canonical transformations generated by constants of motion in the case of the Kepler problem are discussed. It is shown that canonical transformations generated by angular momentum are rotations of the trajectory. Particular attention is paid to canonical transformations generated by the Runge-Lenz vector. It is shown that these transformations change the eccentricity of the orbit. A method of obtaining elliptic trajectories from the circular ones with the help of canonical trajectories is discussed.

Canonical quantum gravity and consistent discretizations

Indian Academy of Sciences (India)

Abstract. This paper covers some developments in canonical quantum gravity that ... derstanding the real Ashtekar variables four dimensionally [4], or the recent work ... Traditionally, canonical formulations of general relativity considered as canonical variables the metric on a spatial slice qab and a canonically conjugate.

CANONICAL RELATIONS BETWEEN BASIC AND MOTOR - SITUATIONAL-MOTOR SKILLS IN SPORT GAMES

Directory of Open Access Journals (Sweden)

Bećir Šabotić

2013-07-01

Full Text Available The aim of this study was to establish the correlation between the predictor-basic motor and situational-motor tests in sports games. On the sample of 62 subjects of the first year of high school was carried out measurements which covered 12 basic and 6 motor variables and situational tests in volleyball and basketball.Based on the results of the canonical correlation analysis, it can be concluded that there is a significant relationship between the predictor variables and a set of criterion variables, situational-motor tests basketball and volleyball. These results are logical given the structure of movements from basketball and volleyball that require a high level of coordination and speed.

Uncertainty relations, zero point energy and the linear canonical group

Science.gov (United States)

Sudarshan, E. C. G.

1993-01-01

The close relationship between the zero point energy, the uncertainty relations, coherent states, squeezed states, and correlated states for one mode is investigated. This group-theoretic perspective enables the parametrization and identification of their multimode generalization. In particular the generalized Schroedinger-Robertson uncertainty relations are analyzed. An elementary method of determining the canonical structure of the generalized correlated states is presented.

Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells

International Nuclear Information System (INIS)

Perkins, Timothy N.; Dentener, Mieke A.; Stassen, Frank R.; Rohde, Gernot G.; Mossman, Brooke T.; Wouters, Emiel F.M.; Reynaert, Niki L.

2016-01-01

Growth and development of the mature lung is a complex process orchestrated by a number of intricate developmental signaling pathways. Wingless-type MMTV-integration site (WNT) signaling plays critical roles in controlling branching morphogenesis cell differentiation, and formation of the conducting and respiratory airways. In addition, WNT pathways are often re-activated in mature lungs during repair and regeneration. WNT- signaling has been elucidated as a crucial contributor to the development of idiopathic pulmonary fibrosis as well as other hyper-proliferative lung diseases. Silicosis, a detrimental occupational lung disease caused by excessive inhalation of crystalline silica dust, is hallmarked by repeated cycles of damaging inflammation, epithelial hyperplasia, and formation of dense, hyalinized nodules of whorled collagen. However, mechanisms of epithelial cell hyperplasia and matrix deposition are not well understood, as most research efforts have focused on the pronounced inflammatory response. Microarray data from our previous studies has revealed a number of WNT-signaling and WNT-target genes altered by crystalline silica in human lung epithelial cells. In the present study, we utilize pathway analysis to designate connections between genes altered by silica in WNT-signaling networks. Furthermore, we confirm microarray findings by QRT-PCR and demonstrate both activation of canonical (β-catenin) and down-regulation of non-canonical (WNT5A) signaling in immortalized (BEAS-2B) and primary (PBEC) human bronchial epithelial cells. These findings suggest that WNT-signaling and cross-talk with other pathways (e.g. Notch), may contribute to proliferative, fibrogenic and inflammatory responses to silica in lung epithelial cells. - Highlights: • Pathway analysis reveals silica-induced WNT-signaling in lung epithelial cells. • Silica-induced canonical WNT-signaling is mediated by autocrine/paracrine signals. • Crystalline silica decreases non-canonical WNT

Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells

Energy Technology Data Exchange (ETDEWEB)

Perkins, Timothy N.; Dentener, Mieke A. [Department of Respiratory Medicine, Maastricht University Medical Centre +, Maastricht University Maastricht (Netherlands); Stassen, Frank R. [Department of Medical Microbiology, Maastricht University Medical Centre +, Maastricht University Maastricht (Netherlands); Rohde, Gernot G. [Department of Respiratory Medicine, Maastricht University Medical Centre +, Maastricht University Maastricht (Netherlands); Mossman, Brooke T. [Department of Pathology, University of Vermont College of Medicine, Burlington, VT (United States); Wouters, Emiel F.M. [Department of Respiratory Medicine, Maastricht University Medical Centre +, Maastricht University Maastricht (Netherlands); Reynaert, Niki L., E-mail: n.reynaert@maastrichtuniversity.nl [Department of Respiratory Medicine, Maastricht University Medical Centre +, Maastricht University Maastricht (Netherlands)

2016-06-15

Growth and development of the mature lung is a complex process orchestrated by a number of intricate developmental signaling pathways. Wingless-type MMTV-integration site (WNT) signaling plays critical roles in controlling branching morphogenesis cell differentiation, and formation of the conducting and respiratory airways. In addition, WNT pathways are often re-activated in mature lungs during repair and regeneration. WNT- signaling has been elucidated as a crucial contributor to the development of idiopathic pulmonary fibrosis as well as other hyper-proliferative lung diseases. Silicosis, a detrimental occupational lung disease caused by excessive inhalation of crystalline silica dust, is hallmarked by repeated cycles of damaging inflammation, epithelial hyperplasia, and formation of dense, hyalinized nodules of whorled collagen. However, mechanisms of epithelial cell hyperplasia and matrix deposition are not well understood, as most research efforts have focused on the pronounced inflammatory response. Microarray data from our previous studies has revealed a number of WNT-signaling and WNT-target genes altered by crystalline silica in human lung epithelial cells. In the present study, we utilize pathway analysis to designate connections between genes altered by silica in WNT-signaling networks. Furthermore, we confirm microarray findings by QRT-PCR and demonstrate both activation of canonical (β-catenin) and down-regulation of non-canonical (WNT5A) signaling in immortalized (BEAS-2B) and primary (PBEC) human bronchial epithelial cells. These findings suggest that WNT-signaling and cross-talk with other pathways (e.g. Notch), may contribute to proliferative, fibrogenic and inflammatory responses to silica in lung epithelial cells. - Highlights: • Pathway analysis reveals silica-induced WNT-signaling in lung epithelial cells. • Silica-induced canonical WNT-signaling is mediated by autocrine/paracrine signals. • Crystalline silica decreases non-canonical WNT

Intersubject information mapping: revealing canonical representations of complex natural stimuli

Directory of Open Access Journals (Sweden)

Nikolaus Kriegeskorte

2015-03-01

Full Text Available Real-world time-continuous stimuli such as video promise greater naturalism for studies of brain function. However, modeling the stimulus variation is challenging and introduces a bias in favor of particular descriptive dimensions. Alternatively, we can look for brain regions whose signal is correlated between subjects, essentially using one subject to model another. Intersubject correlation mapping (ICM allows us to find brain regions driven in a canonical manner across subjects by a complex natural stimulus. However, it requires a direct voxel-to-voxel match between the spatiotemporal activity patterns and is thus only sensitive to common activations sufficiently extended to match up in Talairach space (or in an alternative, e.g. cortical-surface-based, common brain space. Here we introduce the more general approach of intersubject information mapping (IIM. For each brain region, IIM determines how much information is shared between the subjects' local spatiotemporal activity patterns. We estimate the intersubject mutual information using canonical correlation analysis applied to voxels within a spherical searchlight centered on each voxel in turn. The intersubject information estimate is invariant to linear transforms including spatial rearrangement of the voxels within the searchlight. This invariance to local encoding will be crucial in exploring fine-grained brain representations, which cannot be matched up in a common space and, more fundamentally, might be unique to each individual – like fingerprints. IIM yields a continuous brain map, which reflects intersubject information in fine-grained patterns. Performed on data from functional magnetic resonance imaging (fMRI of subjects viewing the same television show, IIM and ICM both highlighted sensory representations, including primary visual and auditory cortices. However, IIM revealed additional regions in higher association cortices, namely temporal pole and orbitofrontal cortex. These

Credible Set Estimation, Analysis, and Applications in Synthetic Aperture Radar Canonical Feature Extraction

Science.gov (United States)

2015-03-26

83 5.1 Marginal PMFs for the cylinder scene at coarse zoom. . . . . . . . . . . . . . . 85 5.2 SAR image of a Nissan Sentra with canonical...of a Nissan Sentra with canonical features extracted by the SPLIT algorithm. 5.2.4 Experiment Summary. A notional algorithm is presented in Figure 5.3

Canonical vs. micro-canonical sampling methods in a 2D Ising model

International Nuclear Information System (INIS)

Kepner, J.

1990-12-01

Canonical and micro-canonical Monte Carlo algorithms were implemented on a 2D Ising model. Expressions for the internal energy, U, inverse temperature, Z, and specific heat, C, are given. These quantities were calculated over a range of temperature, lattice sizes, and time steps. Both algorithms accurately simulate the Ising model. To obtain greater than three decimal accuracy from the micro-canonical method requires that the more complicated expression for Z be used. The overall difference between the algorithms is small. The physics of the problem under study should be the deciding factor in determining which algorithm to use. 13 refs., 6 figs., 2 tabs

Titchmarsh-Weyl theory for canonical systems

Directory of Open Access Journals (Sweden)

Keshav Raj Acharya

2014-11-01

Full Text Available The main purpose of this paper is to develop Titchmarsh- Weyl theory of canonical systems. To this end, we first observe the fact that Schrodinger and Jacobi equations can be written into canonical systems. We then discuss the theory of Weyl m-function for canonical systems and establish the relation between the Weyl m-functions of Schrodinger equations and that of canonical systems which involve Schrodinger equations.

‘Dancing through the Minefield’: Canon Reinstatement Strategies for Women Authors

Directory of Open Access Journals (Sweden)

Dascăl Reghina

2015-12-01

Full Text Available The paper explores the limiting and detrimental effects of biographical criticism and exceptionalism in the efforts of reinstating women authors into the Renaissance canon, by looking into the literary merits of Elizabeth Cary’s The Tragedy of Mariam, The Fair Queen of Jewry and The History of The Life, Reign and Death of Edward II. Whereas the conflation of biography and fiction is a successful recipe for canonization and for the production of feminist icons, it renders the text impotent because of its resulting inability to compete with or to be seen in correlation and interplay with other contemporary texts.

The gauge-invariant canonical energy-momentum tensor

Science.gov (United States)

Lorcé, Cédric

2016-03-01

The canonical energy-momentum tensor is often considered as a purely academic object because of its gauge dependence. However, it has recently been realized that canonical quantities can in fact be defined in a gauge-invariant way provided that strict locality is abandoned, the non-local aspect being dictacted in high-energy physics by the factorization theorems. Using the general techniques for the parametrization of non-local parton correlators, we provide for the first time a complete parametrization of the energy-momentum tensor (generalizing the purely local parametrizations of Ji and Bakker-Leader-Trueman used for the kinetic energy-momentum tensor) and identify explicitly the parts accessible from measurable two-parton distribution functions (TMDs and GPDs). As by-products, we confirm the absence of model-independent relations between TMDs and parton orbital angular momentum, recover in a much simpler way the Burkardt sum rule and derive three similar new sum rules expressing the conservation of transverse momentum.

The gauge-invariant canonical energy-momentum tensor

International Nuclear Information System (INIS)

Lorce, C.

2016-01-01

The canonical energy-momentum tensor is often considered as a purely academic object because of its gauge dependence. However, it has recently been realized that canonical quantities can in fact be defined in a gauge-invariant way provided that strict locality is abandoned, the non-local aspect being dictated in high-energy physics by the factorization theorems. Using the general techniques for the parametrization of non-local parton correlators, we provide for the first time a complete parametrization of the energy-momentum tensor (generalizing the purely local parametrizations of Ji and Bakker-Leader-Trueman used for the kinetic energy-momentum tensor) and identify explicitly the parts accessible from measurable two-parton distribution functions (TMD and GPD). As by-products, we confirm the absence of model-independent relations between TMDs and parton orbital angular momentum, recover in a much simpler way the Burkardt sum rule and derive 3 similar new sum rules expressing the conservation of transverse momentum. (author)

Multireference quantum chemistry through a joint density matrix renormalization group and canonical transformation theory.

Science.gov (United States)

Yanai, Takeshi; Kurashige, Yuki; Neuscamman, Eric; Chan, Garnet Kin-Lic

2010-01-14

We describe the joint application of the density matrix renormalization group and canonical transformation theory to multireference quantum chemistry. The density matrix renormalization group provides the ability to describe static correlation in large active spaces, while the canonical transformation theory provides a high-order description of the dynamic correlation effects. We demonstrate the joint theory in two benchmark systems designed to test the dynamic and static correlation capabilities of the methods, namely, (i) total correlation energies in long polyenes and (ii) the isomerization curve of the [Cu(2)O(2)](2+) core. The largest complete active spaces and atomic orbital basis sets treated by the joint DMRG-CT theory in these systems correspond to a (24e,24o) active space and 268 atomic orbitals in the polyenes and a (28e,32o) active space and 278 atomic orbitals in [Cu(2)O(2)](2+).

A simultaneous CONCOR algorithm for the analysis of two partitioned matrices

NARCIS (Netherlands)

Lafosse, R; Ten Berge, J.M.F.

2006-01-01

A standard approach to derive underlying components from two or more data matrices, holding data from the same individuals or objects, is the (generalized) canonical correlation analysis. This technique finds components (canonical variates) with maximal sums of correlations between them. The

Derivation of Mayer Series from Canonical Ensemble

International Nuclear Information System (INIS)

Wang Xian-Zhi

2016-01-01

Mayer derived the Mayer series from both the canonical ensemble and the grand canonical ensemble by use of the cluster expansion method. In 2002, we conjectured a recursion formula of the canonical partition function of a fluid (X.Z. Wang, Phys. Rev. E 66 (2002) 056102). In this paper we give a proof for this formula by developing an appropriate expansion of the integrand of the canonical partition function. We further derive the Mayer series solely from the canonical ensemble by use of this recursion formula. (paper)

Derivation of Mayer Series from Canonical Ensemble

Science.gov (United States)

Wang, Xian-Zhi

2016-02-01

Mayer derived the Mayer series from both the canonical ensemble and the grand canonical ensemble by use of the cluster expansion method. In 2002, we conjectured a recursion formula of the canonical partition function of a fluid (X.Z. Wang, Phys. Rev. E 66 (2002) 056102). In this paper we give a proof for this formula by developing an appropriate expansion of the integrand of the canonical partition function. We further derive the Mayer series solely from the canonical ensemble by use of this recursion formula.

Process modelling on a canonical basis[Process modelling; Canonical modelling

Energy Technology Data Exchange (ETDEWEB)

Siepmann, Volker

2006-12-20

possible to retrieve symbolically obtained derivatives of arbitrary process properties with respect to process parameters efficiently as a post calculation. The approach is therefore perfectly suitable to perform advanced process systems engineering tasks, such as sensitivity analysis, process optimisation, and data reconciliation. The concept of canonical modelling yields a natural definition of a general exergy state function for second law analysis. By partitioning of exergy into latent, mechanical, and chemical contributions, irreversible effects can be identified specifically, even for black-box models. The calculation core of a new process simulator called Yasim is developed and implemented. The software design follows the concepts described in the theoretical part of this thesis. Numerous exemplary process models are presented to address various subtopics of canonical modelling (author)

Canonical duality theory unified methodology for multidisciplinary study

CERN Document Server

Latorre, Vittorio; Ruan, Ning

2017-01-01

This book on canonical duality theory provides a comprehensive review of its philosophical origin, physics foundation, and mathematical statements in both finite- and infinite-dimensional spaces. A ground-breaking methodological theory, canonical duality theory can be used for modeling complex systems within a unified framework and for solving a large class of challenging problems in multidisciplinary fields in engineering, mathematics, and the sciences. This volume places a particular emphasis on canonical duality theory’s role in bridging the gap between non-convex analysis/mechanics and global optimization.  With 18 total chapters written by experts in their fields, this volume provides a nonconventional theory for unified understanding of the fundamental difficulties in large deformation mechanics, bifurcation/chaos in nonlinear science, and the NP-hard problems in global optimization. Additionally, readers will find a unified methodology and powerful algorithms for solving challenging problems in comp...

Quaternion Linear Canonical Transform Application

OpenAIRE

Bahri, Mawardi

2015-01-01

Quaternion linear canonical transform (QLCT) is a generalization of the classical linear canonical transfom (LCT) using quaternion algebra. The focus of this paper is to introduce an application of the QLCT to study of generalized swept-frequency filter

Canonical transformations and generating functionals

NARCIS (Netherlands)

Broer, L.J.F.; Kobussen, J.A.

1972-01-01

It is shown that canonical transformations for field variables in hamiltonian partial differential equations can be obtained from generating functionals in the same way as classical canonical transformations from generating functions. A simple proof of the relation between infinitesimal invariant

Log canonical thresholds of smooth Fano threefolds

International Nuclear Information System (INIS)

Cheltsov, Ivan A; Shramov, Konstantin A

2008-01-01

The complex singularity exponent is a local invariant of a holomorphic function determined by the integrability of fractional powers of the function. The log canonical thresholds of effective Q-divisors on normal algebraic varieties are algebraic counterparts of complex singularity exponents. For a Fano variety, these invariants have global analogues. In the former case, it is the so-called α-invariant of Tian; in the latter case, it is the global log canonical threshold of the Fano variety, which is the infimum of log canonical thresholds of all effective Q-divisors numerically equivalent to the anticanonical divisor. An appendix to this paper contains a proof that the global log canonical threshold of a smooth Fano variety coincides with its α-invariant of Tian. The purpose of the paper is to compute the global log canonical thresholds of smooth Fano threefolds (altogether, there are 105 deformation families of such threefolds). The global log canonical thresholds are computed for every smooth threefold in 64 deformation families, and the global log canonical thresholds are computed for a general threefold in 20 deformation families. Some bounds for the global log canonical thresholds are computed for 14 deformation families. Appendix A is due to J.-P. Demailly.

Classifying Linear Canonical Relations

OpenAIRE

Lorand, Jonathan

2015-01-01

In this Master's thesis, we consider the problem of classifying, up to conjugation by linear symplectomorphisms, linear canonical relations (lagrangian correspondences) from a finite-dimensional symplectic vector space to itself. We give an elementary introduction to the theory of linear canonical relations and present partial results toward the classification problem. This exposition should be accessible to undergraduate students with a basic familiarity with linear algebra.

Are neoclassical canons valid for southern Chinese faces?

Directory of Open Access Journals (Sweden)

Yasas S N Jayaratne

Full Text Available BACKGROUND: Proportions derived from neoclassical canons, initially described by Renaissance sculptors and painters, are still being employed as aesthetic guidelines during the clinical assessment of the facial morphology. OBJECTIVE: 1. to determine the applicability of neoclassical canons for Southern Chinese faces and 2. to explore gender differences in relation to the applicability of the neoclassical canons and their variants. METHODOLOGY: 3-D photographs acquired from 103 young adults (51 males and 52 females without facial dysmorphology were used to test applicability of four neoclassical canons. Standard anthropometric measurements that determine the facial canons were made on these 3-D images. The validity of the canons as well as their different variants were quantified. PRINCIPAL FINDINGS: The neoclassical cannons seldom applied to these individuals, and facial three-section and orbital canons did not apply at all. The orbitonasal canon was most frequently applicable, with a frequency of 19%. Significant sexual dimorphism was found relative to the prevalence of the variants of facial three-section and orbitonasal canons. CONCLUSION: The neoclassical canons did not appear to apply to our sample when rigorous quantitative measurements were employed. Thus, they should not be used as esthetic goals for craniofacial surgical interventions.

Influence and canonical supremacy: an analysis of how George Herbert Mead demoted Charles Horton Cooley in the sociological canon.

Science.gov (United States)

Jacobs, Glenn

2009-01-01

This analysis assesses the factors underlying Charles Horton Cooley's place in the sociological canon as they relate to George Herbert Mead's puzzling diatribe-echoed in secondary accounts-against Cooley's social psychology and view of the self published scarcely a year after his death. The illocutionary act of publishing his critique stands as an effort to project the image of Mead's intellectual self and enhance his standing among sociologists within and outside the orbit of the University of Chicago. It expressed Mead's ambivalence toward his precursor Cooley, whose influence he never fully acknowledged. In addition, it typifies the contending fractal distinctions of the scientifically discursive versus literary styles of Mead and Cooley, who both founded the interpretive sociological tradition. The contrasting styles and attitudes toward writing of the two figures are discussed, and their implications for the problems of scale that have stymied the symbolic interactionist tradition are explored.

Minimal canonical comprehensive Gröbner systems

OpenAIRE

Manubens, Montserrat; Montes, Antonio

2009-01-01

This is the continuation of Montes' paper "On the canonical discussion of polynomial systems with parameters''. In this paper, we define the Minimal Canonical Comprehensive Gröbner System of a parametric ideal and fix under which hypothesis it exists and is computable. An algorithm to obtain a canonical description of the segments of the Minimal Canonical CGS is given, thus completing the whole MCCGS algorithm (implemented in Maple and Singular). We show its high utility for applications, suc...

Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues.

Science.gov (United States)

Castellano, Leandro; Stebbing, Justin

2013-03-01

MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression. They are characterized by specific maturation processes defined by canonical and non-canonical biogenic pathways. Analysis of ∼0.5 billion sequences from mouse data sets derived from different tissues, developmental stages and cell types, partly characterized by either ablation or mutation of the main proteins belonging to miRNA processor complexes, reveals 66 high-confidence new genomic loci coding for miRNAs that could be processed in a canonical or non-canonical manner. A proportion of the newly discovered miRNAs comprises mirtrons, for which we define a new sub-class. Notably, some of these newly discovered miRNAs are generated from untranslated and open reading frames of coding genes, and we experimentally validate these. We also show that many annotated miRNAs do not present miRNA-like features, as they are neither processed by known processing complexes nor loaded on AGO2; this indicates that the current miRNA miRBase database list should be refined and re-defined. Accordingly, a group of them map on ribosomal RNA molecules, whereas others cannot undergo genuine miRNA biogenesis. Notably, a group of annotated miRNAs are Dgcr8 independent and DICER dependent endogenous small interfering RNAs that derive from a unique hairpin formed from a short interspersed nuclear element.

Canonical Labelling of Site Graphs

Directory of Open Access Journals (Sweden)

Nicolas Oury

2013-06-01

Full Text Available We investigate algorithms for canonical labelling of site graphs, i.e. graphs in which edges bind vertices on sites with locally unique names. We first show that the problem of canonical labelling of site graphs reduces to the problem of canonical labelling of graphs with edge colourings. We then present two canonical labelling algorithms based on edge enumeration, and a third based on an extension of Hopcroft's partition refinement algorithm. All run in quadratic worst case time individually. However, one of the edge enumeration algorithms runs in sub-quadratic time for graphs with "many" automorphisms, and the partition refinement algorithm runs in sub-quadratic time for graphs with "few" bisimulation equivalences. This suite of algorithms was chosen based on the expectation that graphs fall in one of those two categories. If that is the case, a combined algorithm runs in sub-quadratic worst case time. Whether this expectation is reasonable remains an interesting open problem.

Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications.

Science.gov (United States)

Suseela, Y V; Narayanaswamy, Nagarjun; Pratihar, Sumon; Govindaraju, Thimmaiah

2018-02-05

The structural diversity and functional relevance of nucleic acids (NAs), mainly deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are indispensable for almost all living organisms, with minute aberrations in their structure and function becoming causative factors in numerous human diseases. The standard structures of NAs, termed canonical structures, are supported by Watson-Crick hydrogen bonding. Under special physiological conditions, NAs adopt distinct spatial organisations, giving rise to non-canonical conformations supported by hydrogen bonding other than the Watson-Crick type; such non-canonical structures have a definite function in controlling gene expression and are considered as novel diagnostic and therapeutic targets. Development of molecular probes for these canonical and non-canonical DNA/RNA structures has been an active field of research. Among the numerous probes studied, probes with turn-on fluorescence in the far-red (600-750 nm) region are highly sought-after due to minimal autofluorescence and cellular damage. Far-red fluorescent probes are vital for real-time imaging of NAs in live cells as they provide good resolution and minimal perturbation of the cell under investigation. In this review, we present recent advances in the area of far-red fluorescent probes of DNA/RNA and non-canonical G-quadruplex structures. For the sake of continuity and completeness, we provide a brief overview of visible fluorescent probes. Utmost importance is given to design criteria, characteristic properties and biological applications, including in cellulo imaging, apart from critical discussion on limitations of the far-red fluorescent probes. Finally, we offer current and future prospects in targeting canonical and non-canonical NAs specific to cellular organelles, through sequence- and conformation-specific far-red fluorescent probes. We also cover their implications in chemical and molecular biology, with particular focus on decoding various disease

Canonical forms for single-qutrit Clifford+T operators

OpenAIRE

Glaudell, Andrew N.; Ross, Neil J.; Taylor, Jacob M.

2018-01-01

We introduce canonical forms for single qutrit Clifford+T circuits and prove that every single-qutrit Clifford+T operator admits a unique such canonical form. We show that our canonical forms are T-optimal in the sense that among all the single-qutrit Clifford+T circuits implementing a given operator our canonical form uses the least number of T gates. Finally, we provide an algorithm which inputs the description of an operator (as a matrix or a circuit) and constructs the canonical form for ...

On the coupling of statistic sum of canonical and large canonical ensemble of interacting particles

International Nuclear Information System (INIS)

Vall, A.N.

2000-01-01

Potentiality of refining the known result based on analytic properties of a great statistical sum, as a function of the absolute activity of the boundary integral contribution into statistical sum, is considered. A strict asymptotic ratio between statistical sums of canonical and large canonical ensemble of interacting particles was derived [ru

The Literary Canon in the Age of New Media

DEFF Research Database (Denmark)

Backe, Hans-Joachim

2015-01-01

and mediality of the canon. In a development that has largely gone unnoticed outside German speaking countries, new approaches for discussing current and future processes of canonization have been developed in recent years. One pivotal element of this process has been a thorough re-evaluation new media......The article offers a comparative overview of the diverging courses of the canon debate in Anglophone and Germanophone contexts. While the Anglophone canon debate has focused on the politics of canon composition, the Germanophone canon debate has been more concerned with the malleability...

An introduction to the theory of canonical matrices

CERN Document Server

Turnbull, H W

2004-01-01

Thorough and self-contained, this penetrating study of the theory of canonical matrices presents a detailed consideration of all the theory's principal features. Topics include elementary transformations and bilinear and quadratic forms; canonical reduction of equivalent matrices; subgroups of the group of equivalent transformations; and rational and classical canonical forms. The final chapters explore several methods of canonical reduction, including those of unitary and orthogonal transformations. 1952 edition. Index. Appendix. Historical notes. Bibliographies. 275 problems.

On the Theotokia in the Canon for St. Wenceslas

Directory of Open Access Journals (Sweden)

Vittorio Springfield Tomelleri

2016-08-01

Full Text Available The present paper reports on the first results from the investigation of the Church Slavonic canon composed for the Czech saint Wenceslas (Václav, Viacheslav and preserved in East Slavic manuscripts from the end of the 11th century. Particular attention has been given to the analysis of the Marian hymns (theotokia, whose Greek originals could be detected in all cases but one (the first ode. The Slavonic translation has been thoroughly compared with its Greek original and with other versions taken from different canons. Following the critical edition of each single Slavonic text, a synoptic interlinear version is provided, which allows the immediate identification of common readings, errors, and omissions. The theotokia contained in the canon for Wenceslas show interesting similarities with the textual tradition documented in the Oktoechos and the Common of Saints, the latter being usually associated with Clement of Ohrid; a possible explanation of this fact could be that these texts were not newly translated from Greek, but taken from already existing hymnographic sources. Undoubtedly, much deeper analysis is required in order to disentangle the textual history of these texts; the collected material aims to provide a good starting point for further investigations.

佳能EOS系列广告策略分析%Analysis of Canon EOS Advertisement Strategies

Institute of Scientific and Technical Information of China (English)

杜丹阳

2015-01-01

文章主要研究佳能EOS系列相机的广告策略问题，运用文献分析和实证分析的方法，结合其广告效果，从广告市场策略，产品策略，媒介策略，表现策略等方面入手，对相机业巨头佳能旗下EOS系列的广告策略进行分析评价。通过对广告策略的分析，探讨其广告战略的成功之处，为我国企业的广告营销提供借鉴经验。%The article mainly talks about the advertisement strategies of Canon EOS. Using the method of document research and empirical analysis and combining with the advertising effect to analyze the advertisement strategies of Canon EOS from the aspects of advertising market strategy, product strategy, media strategy and performance strategy. According to the analysis to conclude its success and provides experience for corporations' advertising marketing in China.

Black-hole horizons in modified spacetime structures arising from canonical quantum gravity

International Nuclear Information System (INIS)

Bojowald, Martin; Paily, George M; Reyes, Juan D; Tibrewala, Rakesh

2011-01-01

Several properties of canonical quantum gravity modify spacetime structures, sometimes to the degree that no effective line elements exist to describe the geometry. An analysis of solutions, for instance in the context of black holes, then requires new insights. In this paper, standard definitions of horizons in spherical symmetry are first reformulated canonically, and then evaluated for solutions of equations and constraints modified by inverse-triad corrections of loop quantum gravity. When possible, a spacetime analysis is performed which reveals a mass threshold for black holes and small changes to Hawking radiation. For more general conclusions, canonical perturbation theory is developed to second order to include back-reaction from matter. The results shed light on the questions of whether renormalization of Newton's constant or other modifications of horizon conditions should be taken into account in computations of black-hole entropy in loop quantum gravity.

Canonical cortical circuits: current evidence and theoretical implications

Directory of Open Access Journals (Sweden)

Capone F

2016-04-01

Full Text Available Fioravante Capone,1,2 Matteo Paolucci,1,2 Federica Assenza,1,2 Nicoletta Brunelli,1,2 Lorenzo Ricci,1,2 Lucia Florio,1,2 Vincenzo Di Lazzaro1,2 1Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy; 2Fondazione Alberto Sordi – Research Institute for Aging, Rome, ItalyAbstract: Neurophysiological and neuroanatomical studies have found that the same basic structural and functional organization of neuronal circuits exists throughout the cortex. This kind of cortical organization, termed canonical circuit, has been functionally demonstrated primarily by studies involving visual striate cortex, and then, the concept has been extended to different cortical areas. In brief, the canonical circuit is composed of superficial pyramidal neurons of layers II/III receiving different inputs and deep pyramidal neurons of layer V that are responsible for cortex output. Superficial and deep pyramidal neurons are reciprocally connected, and inhibitory interneurons participate in modulating the activity of the circuit. The main intuition of this model is that the entire cortical network could be modeled as the repetition of relatively simple modules composed of relatively few types of excitatory and inhibitory, highly interconnected neurons. We will review the origin and the application of the canonical cortical circuit model in the six sections of this paper. The first section (The origins of the concept of canonical circuit: the cat visual cortex reviews the experiments performed in the cat visual cortex, from the origin of the concept of canonical circuit to the most recent developments in the modelization of cortex. The second (The canonical circuit in neocortex and third (Toward a canonical circuit in agranular cortex sections try to extend the concept of canonical circuit to other cortical areas, providing some significant examples of circuit functioning in different cytoarchitectonic

The canon as text for a biblical theology

Directory of Open Access Journals (Sweden)

James A. Loader

2005-10-01

Full Text Available The novelty of the canonical approach is questioned and its fascination at least partly traced to the Reformation, as well as to the post-Reformation’s need for a clear and authoritative canon to perform the function previously performed by the church. This does not minimise the elusiveness and deeply contradictory positions both within the canon and triggered by it. On the one hand, the canon itself is a centripetal phenomenon and does play an important role in exegesis and theology. Even so, on the other hand, it not only contains many difficulties, but also causes various additional problems of a formal as well as a theological nature. The question is mooted whether the canonical approach alleviates or aggravates the dilemma. Since this approach has become a major factor in Christian theology, aspects of the Christian canon are used to gauge whether “canon” is an appropriate category for eliminating difficulties that arise by virtue of its own existence. Problematic uses and appropriations of several Old Testament canons are advanced, as well as evidence in the New Testament of a consciousness that the “old” has been surpassed(“Überbietungsbewußtsein”. It is maintained that at least the Childs version of the canonical approach fails to smooth out these and similar difficulties. As a method it can cater for the New Testament’s (superior role as the hermeneutical standard for evaluating the Old, but flounders on its inability to create the theological unity it claims can solve religious problems exposed by Old Testament historical criticism. It is concluded that canon as a category cannot be dispensed with, but is useful for the opposite of the purpose to which it is conventionally put: far from bringing about theological “unity” or producing a standard for “correct” exegesis, it requires different readings of different canons.

A Canonical Approach to the Argument/Adjunct Distinction

Directory of Open Access Journals (Sweden)

Diana Forker

2014-01-01

Full Text Available This paper provides an account of the argument/adjunct distinction implementing the 'canonical approach'. I identify five criteria (obligatoriness, latency, co-occurrence restrictions, grammatical relations, and iterability and seven diagnostic tendencies that can be used to distinguish canonical arguments from canonical adjuncts. I then apply the criteria and tendencies to data from the Nakh-Daghestanian language Hinuq. Hinuq makes extensive use of spatial cases for marking adjunct-like and argument-like NPs. By means of the criteria and tendencies it is possible to distinguish spatial NPs that come close to canonical arguments from those that are canonical adjuncts, and to place the remaining NPs bearing spatial cases within the argument-adjunct continuum.

Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis.

Science.gov (United States)

Oliveira Junior, Silvio A; Padovani, Carlos R; Rodrigues, Sergio A; Silva, Nilza R; Martinez, Paula F; Campos, Dijon Hs; Okoshi, Marina P; Okoshi, Katashi; Dal-Pai, Maeli; Cicogna, Antonio C

2013-04-15

Although hypercaloric interventions are associated with nutritional, endocrine, metabolic, and cardiovascular disorders in obesity experiments, a rational distinction between the effects of excess adiposity and the individual roles of dietary macronutrients in relation to these disturbances has not previously been studied. This investigation analyzed the correlation between ingested macronutrients (including sucrose and saturated and unsaturated fatty acids) plus body adiposity and metabolic, hormonal, and cardiovascular effects in rats with diet-induced obesity. Normotensive Wistar-Kyoto rats were submitted to Control (CD; 3.2 Kcal/g) and Hypercaloric (HD; 4.6 Kcal/g) diets for 20 weeks followed by nutritional evaluation involving body weight and adiposity measurement. Metabolic and hormonal parameters included glycemia, insulin, insulin resistance, and leptin. Cardiovascular analysis included systolic blood pressure profile, echocardiography, morphometric study of myocardial morphology, and myosin heavy chain (MHC) protein expression. Canonical correlation analysis was used to evaluate the relationships between dietary macronutrients plus adiposity and metabolic, hormonal, and cardiovascular parameters. Although final group body weights did not differ, HD presented higher adiposity than CD. Diet induced hyperglycemia while insulin and leptin levels remained unchanged. In a cardiovascular context, systolic blood pressure increased with time only in HD. Additionally, in vivo echocardiography revealed cardiac hypertrophy and improved systolic performance in HD compared to CD; and while cardiomyocyte size was unchanged by diet, nuclear volume and collagen interstitial fraction both increased in HD. Also HD exhibited higher relative β-MHC content and β/α-MHC ratio than their Control counterparts. Importantly, body adiposity was weakly associated with cardiovascular effects, as saturated fatty acid intake was directly associated with most cardiac remodeling

An approach for generating trajectory-based dynamics which conserves the canonical distribution in the phase space formulation of quantum mechanics. II. Thermal correlation functions.

Science.gov (United States)

Liu, Jian; Miller, William H

2011-03-14

We show the exact expression of the quantum mechanical time correlation function in the phase space formulation of quantum mechanics. The trajectory-based dynamics that conserves the quantum canonical distribution-equilibrium Liouville dynamics (ELD) proposed in Paper I is then used to approximately evaluate the exact expression. It gives exact thermal correlation functions (of even nonlinear operators, i.e., nonlinear functions of position or momentum operators) in the classical, high temperature, and harmonic limits. Various methods have been presented for the implementation of ELD. Numerical tests of the ELD approach in the Wigner or Husimi phase space have been made for a harmonic oscillator and two strongly anharmonic model problems, for each potential autocorrelation functions of both linear and nonlinear operators have been calculated. It suggests ELD can be a potentially useful approach for describing quantum effects for complex systems in condense phase.

Network analysis reveals that bacteria and fungi form modules that correlate independently with soil parameters.

Science.gov (United States)

de Menezes, Alexandre B; Prendergast-Miller, Miranda T; Richardson, Alan E; Toscas, Peter; Farrell, Mark; Macdonald, Lynne M; Baker, Geoff; Wark, Tim; Thrall, Peter H

2015-08-01

Network and multivariate statistical analyses were performed to determine interactions between bacterial and fungal community terminal restriction length polymorphisms as well as soil properties in paired woodland and pasture sites. Canonical correspondence analysis (CCA) revealed that shifts in woodland community composition correlated with soil dissolved organic carbon, while changes in pasture community composition correlated with moisture, nitrogen and phosphorus. Weighted correlation network analysis detected two distinct microbial modules per land use. Bacterial and fungal ribotypes did not group separately, rather all modules comprised of both bacterial and fungal ribotypes. Woodland modules had a similar fungal : bacterial ribotype ratio, while in the pasture, one module was fungal dominated. There was no correspondence between pasture and woodland modules in their ribotype composition. The modules had different relationships to soil variables, and these contrasts were not detected without the use of network analysis. This study demonstrated that fungi and bacteria, components of the soil microbial communities usually treated as separate functional groups as in a CCA approach, were co-correlated and formed distinct associations in these adjacent habitats. Understanding these distinct modular associations may shed more light on their niche space in the soil environment, and allow a more realistic description of soil microbial ecology and function. © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.

Incidence Rate of Canonical vs. Derived Medical Terminology in Natural Language.

Science.gov (United States)

Topac, Vasile; Jurcau, Daniel-Alexandru; Stoicu-Tivadar, Vasile

2015-01-01

Medical terminology appears in the natural language in multiple forms: canonical, derived or inflected form. This research presents an analysis of the form in which medical terminology appears in Romanian and English language. The sources of medical language used for the study are web pages presenting medical information for patients and other lay users. The results show that, in English, medical terminology tends to appear more in canonical form while, in the case of Romanian, it is the opposite. This paper also presents the service that was created to perform this analysis. This tool is available for the general public, and it is designed to be easily extensible, allowing the addition of other languages.

Statistical analysis of aerosol species, trace gasses, and meteorology in Chicago.

Science.gov (United States)

Binaku, Katrina; O'Brien, Timothy; Schmeling, Martina; Fosco, Tinamarie

2013-09-01

Both canonical correlation analysis (CCA) and principal component analysis (PCA) were applied to atmospheric aerosol and trace gas concentrations and meteorological data collected in Chicago during the summer months of 2002, 2003, and 2004. Concentrations of ammonium, calcium, nitrate, sulfate, and oxalate particulate matter, as well as, meteorological parameters temperature, wind speed, wind direction, and humidity were subjected to CCA and PCA. Ozone and nitrogen oxide mixing ratios were also included in the data set. The purpose of statistical analysis was to determine the extent of existing linear relationship(s), or lack thereof, between meteorological parameters and pollutant concentrations in addition to reducing dimensionality of the original data to determine sources of pollutants. In CCA, the first three canonical variate pairs derived were statistically significant at the 0.05 level. Canonical correlation between the first canonical variate pair was 0.821, while correlations of the second and third canonical variate pairs were 0.562 and 0.461, respectively. The first canonical variate pair indicated that increasing temperatures resulted in high ozone mixing ratios, while the second canonical variate pair showed wind speed and humidity's influence on local ammonium concentrations. No new information was uncovered in the third variate pair. Canonical loadings were also interpreted for information regarding relationships between data sets. Four principal components (PCs), expressing 77.0 % of original data variance, were derived in PCA. Interpretation of PCs suggested significant production and/or transport of secondary aerosols in the region (PC1). Furthermore, photochemical production of ozone and wind speed's influence on pollutants were expressed (PC2) along with overall measure of local meteorology (PC3). In summary, CCA and PCA results combined were successful in uncovering linear relationships between meteorology and air pollutants in Chicago and

Restoring canonical partition functions from imaginary chemical potential

Science.gov (United States)

Bornyakov, V. G.; Boyda, D.; Goy, V.; Molochkov, A.; Nakamura, A.; Nikolaev, A.; Zakharov, V. I.

2018-03-01

Using GPGPU techniques and multi-precision calculation we developed the code to study QCD phase transition line in the canonical approach. The canonical approach is a powerful tool to investigate sign problem in Lattice QCD. The central part of the canonical approach is the fugacity expansion of the grand canonical partition functions. Canonical partition functions Zn(T) are coefficients of this expansion. Using various methods we study properties of Zn(T). At the last step we perform cubic spline for temperature dependence of Zn(T) at fixed n and compute baryon number susceptibility χB/T2 as function of temperature. After that we compute numerically ∂χ/∂T and restore crossover line in QCD phase diagram. We use improved Wilson fermions and Iwasaki gauge action on the 163 × 4 lattice with mπ/mρ = 0.8 as a sandbox to check the canonical approach. In this framework we obtain coefficient in parametrization of crossover line Tc(µ2B) = Tc(C-ĸµ2B/T2c) with ĸ = -0.0453 ± 0.0099.

The Bargmann transform and canonical transformations

International Nuclear Information System (INIS)

Villegas-Blas, Carlos

2002-01-01

This paper concerns a relationship between the kernel of the Bargmann transform and the corresponding canonical transformation. We study this fact for a Bargmann transform introduced by Thomas and Wassell [J. Math. Phys. 36, 5480-5505 (1995)]--when the configuration space is the two-sphere S 2 and for a Bargmann transform that we introduce for the three-sphere S 3 . It is shown that the kernel of the Bargmann transform is a power series in a function which is a generating function of the corresponding canonical transformation (a classical analog of the Bargmann transform). We show in each case that our canonical transformation is a composition of two other canonical transformations involving the complex null quadric in C 3 or C 4 . We also describe quantizations of those two other canonical transformations by dealing with spaces of holomorphic functions on the aforementioned null quadrics. Some of these quantizations have been studied by Bargmann and Todorov [J. Math. Phys. 18, 1141-1148 (1977)] and the other quantizations are related to the work of Guillemin [Integ. Eq. Operator Theory 7, 145-205 (1984)]. Since suitable infinite linear combinations of powers of the generating functions are coherent states for L 2 (S 2 ) or L 2 (S 3 ), we show finally that the studied Bargmann transforms are actually coherent states transforms

Canonical ensembles and nonzero density quantum chromodynamics

International Nuclear Information System (INIS)

Hasenfratz, A.; Toussaint, D.

1992-01-01

We study QCD with nonzero chemical potential on 4 4 lattices by averaging over the canonical partition functions, or sectors with fixed quark number. We derive a condensed matrix of size 2x3xL 3 whose eigenvalues can be used to find the canonical partition functions. We also experiment with a weight for configuration generation which respects the Z(3) symmetry which forces the canonical partition function to be zero for quark numbers that are not multiples of three. (orig.)

Application of Adjusted Canonical Correlation Analysis (ACCA) to study the association between mathematics in Level 1 and Level 2 and performance of engineering disciplines in Level 2

Science.gov (United States)

Peiris, T. S. G.; Nanayakkara, K. A. D. S. A.

2017-09-01

Mathematics plays a key role in engineering sciences as it assists to develop the intellectual maturity and analytical thinking of engineering students and exploring the student academic performance has received great attention recently. The lack of control over covariates motivates the need for their adjustment when measuring the degree of association between two sets of variables in Canonical Correlation Analysis (CCA). Thus to examine the individual effects of mathematics in Level 1 and Level 2 on engineering performance in Level 2, two adjusted analyses in CCA: Part CCA and Partial CCA were applied for the raw marks of engineering undergraduates for three different disciplines, at the Faculty of Engineering, University of Moratuwa, Sri Lanka. The joint influence of mathematics in Level 1 and Level 2 is significant on engineering performance in Level 2 irrespective of the engineering disciplines. The individual effect of mathematics in Level 2 is significantly higher compared to the individual effect of mathematics in Level 1 on engineering performance in Level 2. Furthermore, the individual effect of mathematics in Level 1 can be negligible. But, there would be a notable indirect effect of mathematics in Level 1 on engineering performance in Level 2. It can be concluded that the joint effect of mathematics in both Level 1 and Level 2 is immensely beneficial to improve the overall academic performance at the end of Level 2 of the engineering students. Furthermore, it was found that the impact mathematics varies among engineering disciplines. As partial CCA and partial CCA are not widely explored in applied work, it is recommended to use these techniques for various applications.

Backlund transformations as canonical transformations

International Nuclear Information System (INIS)

Villani, A.; Zimerman, A.H.

1977-01-01

Toda and Wadati as well as Kodama and Wadati have shown that the Backlund transformations, for the exponential lattice equation, sine-Gordon equation, K-dV (Korteweg de Vries) equation and modifies K-dV equation, are canonical transformation. It is shown that the Backlund transformation for the Boussinesq equation, for a generalized K-dV equation, for a model equation for shallow water waves and for the nonlinear Schroedinger equation are also canonical transformations [pt

El Escritor y las Normas del Canon Literario (The Writer and the Norms of the Literary Canon).

Science.gov (United States)

Policarpo, Alcibiades

This paper speculates about whether a literary canon exists in contemporary Latin American literature, particularly in the prose genre. The paper points to Carlos Fuentes, Gabriel Garcia Marquez, and Mario Vargas Llosa as the three authors who might form this traditional and liberal canon with their works "La Muerte de Artemio Cruz"…

Periodicity, the Canon and Sport

Directory of Open Access Journals (Sweden)

Thomas F. Scanlon

2015-10-01

Full Text Available The topic according to this title is admittedly a broad one, embracing two very general concepts of time and of the cultural valuation of artistic products. Both phenomena are, in the present view, largely constructed by their contemporary cultures, and given authority to a great extent from the prestige of the past. The antiquity of tradition brings with it a certain cachet. Even though there may be peripheral debates in any given society which question the specifics of periodization or canonicity, individuals generally accept the consensus designation of a sequence of historical periods and they accept a list of highly valued artistic works as canonical or authoritative. We will first examine some of the processes of periodization and of canon-formation, after which we will discuss some specific examples of how these processes have worked in the sport of two ancient cultures, namely Greece and Mesoamerica.

Constructing canonical bases of quantized enveloping algebras

OpenAIRE

Graaf, W.A. de

2001-01-01

An algorithm for computing the elements of a given weight of the canonical basis of a quantized enveloping algebra is described. Subsequently, a similar algorithm is presented for computing the canonical basis of a finite-dimensional module.

Canonical and Non-Canonical NF-κB Signaling Promotes Breast Cancer Tumor-Initiating Cells

Science.gov (United States)

Kendellen, Megan F.; Bradford, Jennifer W.; Lawrence, Cortney L.; Clark, Kelly S.; Baldwin, Albert S.

2014-01-01

Tumor-initiating cells (TICs) are a sub-population of cells that exhibit a robust ability to self-renew and contribute to the formation of primary tumors, the relapse of previously treated tumors, and the development of metastases. TICs have been identified in various tumors, including those of the breast, and are particularly enriched in the basal-like and claudin-low subtypes of breast cancer. The signaling pathways that contribute to the function and maintenance of TICs are under intense study. We explored the potential involvement of the NF-κB family of transcription factors in TICs in cell lines that are representative of basal-like and claudin-low breast cancer. NF-κB was found to be activated in breast cancer cells that form tumorspheres efficiently. Moreover, both canonical and non-canonical NF-κB signaling is required for these cells to self-renew in vitro and to form xenograft tumors efficiently in vivo using limiting dilutions of cells. Consistent with this, canonical and non-canonical NF-κB signaling is activated in TICs isolated from breast cancer cell lines. Experimental results indicate that NF-κB promotes the function of TICs by stimulating epithelial-to-mesenchymal transition (EMT) and by upregulating the expression of the inflammatory cytokines IL-1β and IL-6. The results suggest the use of NF-κB inhibitors for clinical therapy of certain breast cancers. PMID:23474754

‘Canonization in early twentieth-century Chinese art history’

Directory of Open Access Journals (Sweden)

Guo Hui

2014-06-01

Full Text Available Since the 1980s, the discussion of canons has been a dominant theme in the discipline of Western art history. Various concerns have emerged regarding ‘questions of artistic judgment’, ‘the history genesis of masterpieces’, ‘variations in taste’, ‘the social instruments of canonicity’, and ‘how canons disappear’. Western art historians have considered how the canon’s appearance in Western visual art embodies aesthetic, ideological, cultural, social, and symbolic values. In Chinese art history, the idea of a canon including masterpieces, important artists, and forms of art, dates back to the mid ninth century when Zhang Yanyuan wrote his painting history Record of Famous Painters of All the Dynasties. Faced with quite different political, economic, and social conditions amid the instability of the early twentieth century, Chinese scholars attempted to discover new canons for cultural orthodoxy and authority. Modern means for canonization, such as museums and exhibition displays, cultural and academic institutions, and massive art publications with image reproduction in good quality, brought the process up to an unprecedented speed. It is true that most of these means have comparable counterparts in pre-modern times. However, their enormous scope and overwhelming influence are far beyond the reach of their imperial counterparts. Through an inter-textual reading of the publications on Chinese art history in early twentieth-century China, this paper explores the transformation of canons in order to shed light on why and how canonical formation happened during the Republican period of China. Despite the diverse styles and strategies which Chinese writers used in their narratives, Chinese art historical books produced during the Republican period canonized and de-canonized artworks. In this paper, the discussion of these texts, with reference to other art historical works, comprises three parts: 1 canon formation of artistic forms

The degeneracy problem in non-canonical inflation

International Nuclear Information System (INIS)

Easson, Damien A.; Powell, Brian A.

2013-01-01

While attempting to connect inflationary theories to observational physics, a potential difficulty is the degeneracy problem: a single set of observables maps to a range of different inflaton potentials. Two important classes of models affected by the degeneracy problem are canonical and non-canonical models, the latter marked by the presence of a non-standard kinetic term that generates observables beyond the scalar and tensor two-point functions on CMB scales. The degeneracy problem is manifest when these distinguishing observables go undetected. We quantify the size of the resulting degeneracy in this case by studying the most well-motivated non-canonical theory having Dirac-Born-Infeld Lagrangian. Beyond the scalar and tensor two-point functions on CMB scales, we then consider the possible detection of equilateral non-Gaussianity at Planck-precision and a measurement of primordial gravitational waves from prospective space-based laser interferometers. The former detection breaks the degeneracy with canonical inflation but results in poor reconstruction prospects, while the latter measurement enables a determination of n T which, while not breaking the degeneracy, can be shown to greatly improve the non-canonical reconstruction

Stable micron-scale holes are a general feature of canonical holins.

Science.gov (United States)

Savva, Christos G; Dewey, Jill S; Moussa, Samir H; To, Kam H; Holzenburg, Andreas; Young, Ry

2014-01-01

At a programmed time in phage infection cycles, canonical holins suddenly trigger to cause lethal damage to the cytoplasmic membrane, resulting in the cessation of respiration and the non-specific release of pre-folded, fully active endolysins to the periplasm. For the paradigm holin S105 of lambda, triggering is correlated with the formation of micron-scale membrane holes, visible as interruptions in the bilayer in cryo-electron microscopic images and tomographic reconstructions. Here we report that the size distribution of the holes is stable for long periods after triggering. Moreover, early triggering caused by an early lysis allele of S105 formed approximately the same number of holes, but the lesions were significantly smaller. In contrast, early triggering prematurely induced by energy poisons resulted in many fewer visible holes, consistent with previous sizing studies. Importantly, the unrelated canonical holins P2 Y and T4 T were found to cause the formation of holes of approximately the same size and number as for lambda. In contrast, no such lesions were visible after triggering of the pinholin S(21) 68. These results generalize the hole formation phenomenon for canonical holins. A model is presented suggesting the unprecedentedly large size of these holes is related to the timing mechanism. © 2013 John Wiley & Sons Ltd.

Spanish Literature and Spectrality : Notes on a Haunted Canon

NARCIS (Netherlands)

Valdivia, Pablo

In Spanish Literature, Crisis and Spectrality: Notes on a Haunted Canon, Prof. Dr. Pablo Valdivia analyses the contradictions and complexities of the Spanish traditional canon from a transnational approach. Valdivia explores this particular canon as a 'haunted house' by focusing on the specific

The Meridians of Reference of Indian Astronomical Canons

Science.gov (United States)

Mercier, R.

The canons of Sanskrit astronomy depend on mean motions which are normally postulated to refer to the central meridian of Ujjain. The present work is a statistical analysis of these mean motions designed to discover the optimum position of the meridian, by comparison with modern mean motions. This follows earlier work done by Billard in determining the optimum year.

Total reduplication in Japanese ideophones: An exercise in Localized Canonical Typology

Directory of Open Access Journals (Sweden)

Nahyun Kwon

2017-05-01

Full Text Available Cross-linguistically, reduplication associated with iconic readings, such as plurality, iteration, and continuation, is prevalent in ideophones. However, not all reduplicative processes in ideophones are clearly iconic. Notably, both less and more iconic uses of reduplication are encountered in ordinary vocabulary resulting in the overlapping semantic functions of reduplication between ideophonic and non-ideophonic (i.e., prosaic lexical categories. Given this, the aim of this paper is not to establish one clear-cut point to distinguish ideophonic reduplication from prosaic reduplication that may be impossible, but to specify dimensions of possibilities along which several instances of ideophonic and prosaic reduplication can be calibrated, using Canonical Typology (Corbett 2003; 2005; 2006; 2007; 2012; 2015. The current paper adopts the canonical approach of typology in an innovative way – not to compare a reduplicative phenomenon across languages (classic “typology”, but within a language by drawing ideophonic and prosaic data from Japanese, which is rich in reduplication and ideophones. Measuring the canonicity values of the various occurring types of ideophonic and prosaic reduplication against six criteria for canonical ideophonic reduplication, this paper shows how many and what criteria can differentiate the two sets of phenomena. Consequently, it reveals how ideophonic and prosaic reduplication are alike or different from each other. It also demonstrates the utility of Localized Canonical Typology, for the precise description and analysis of complex categories in a single language.

Canonizing certain Borel equivalences for Silver forcing

Czech Academy of Sciences Publication Activity Database

Doucha, Michal

2012-01-01

Roč. 159, č. 13 (2012), s. 2973-2979 ISSN 0166-8641. [Prague Symposium on General Topology and its Relations to Modern Analysis and Algebra /11./. Prague, 07.08.2011-12.08.2011] Institutional research plan: CEZ:AV0Z10190503 Keywords : Borel equivalence relations * silver ideal * canonical Ramsey theorem Subject RIV: BA - General Mathematics Impact factor: 0.562, year: 2012 http://www.sciencedirect.com/science/article/pii/S0166864112002180#

Diagrammatic analysis of correlations in polymer fluids: Cluster diagrams via Edwards' field theory

International Nuclear Information System (INIS)

Morse, David C.

2006-01-01

Edwards' functional integral approach to the statistical mechanics of polymer liquids is amenable to a diagrammatic analysis in which free energies and correlation functions are expanded as infinite sums of Feynman diagrams. This analysis is shown to lead naturally to a perturbative cluster expansion that is closely related to the Mayer cluster expansion developed for molecular liquids by Chandler and co-workers. Expansion of the functional integral representation of the grand-canonical partition function yields a perturbation theory in which all quantities of interest are expressed as functionals of a monomer-monomer pair potential, as functionals of intramolecular correlation functions of non-interacting molecules, and as functions of molecular activities. In different variants of the theory, the pair potential may be either a bare or a screened potential. A series of topological reductions yields a renormalized diagrammatic expansion in which collective correlation functions are instead expressed diagrammatically as functionals of the true single-molecule correlation functions in the interacting fluid, and as functions of molecular number density. Similar renormalized expansions are also obtained for a collective Ornstein-Zernicke direct correlation function, and for intramolecular correlation functions. A concise discussion is given of the corresponding Mayer cluster expansion, and of the relationship between the Mayer and perturbative cluster expansions for liquids of flexible molecules. The application of the perturbative cluster expansion to coarse-grained models of dense multi-component polymer liquids is discussed, and a justification is given for the use of a loop expansion. As an example, the formalism is used to derive a new expression for the wave-number dependent direct correlation function and recover known expressions for the intramolecular two-point correlation function to first-order in a renormalized loop expansion for coarse-grained models of

Deviations from Wick's theorem in the canonical ensemble

Science.gov (United States)

Schönhammer, K.

2017-07-01

Wick's theorem for the expectation values of products of field operators for a system of noninteracting fermions or bosons plays an important role in the perturbative approach to the quantum many-body problem. A finite-temperature version holds in the framework of the grand canonical ensemble, but not for the canonical ensemble appropriate for systems with fixed particle number such as ultracold quantum gases in optical lattices. Here we present formulas for expectation values of products of field operators in the canonical ensemble using a method in the spirit of Gaudin's proof of Wick's theorem for the grand canonical case. The deviations from Wick's theorem are examined quantitatively for two simple models of noninteracting fermions.

Canonical pseudotensors, Sparling's form and Noether currents

International Nuclear Information System (INIS)

Szabados, L.B.

1991-09-01

The canonical energy - momentum and spin pseudotensors of the Einstein theory are studied in two ways. First they are studied in the framework of Lagrangian formalism. It is shown, that for first order Lagrangian and rigid basis description the canonical energy - momentum, the canonical spin, and the Noether current are tensorial quantities, and the canonial energy - momentum and spin tensors satisfy the tensorial Belinfante-Rosenfeld equations. Then the differential geometric unification and reformulation of the previous different pseudotensorial approaches is given. Finally, for any vector field on the spacetime an (m-1) form, called the Noether form is defined. (K.A.) 34 refs

Canonical symmetry of a constrained Hamiltonian system and canonical Ward identity

International Nuclear Information System (INIS)

Li, Zi-ping

1995-01-01

An algorithm for the construction of the generators of the gauge transformation of a constrained Hamiltonian system is given. The relationships among the coefficients connecting the first constraints in the generator are made clear. Starting from the phase space generating function of the Green function, the Ward identity in canonical formalism is deduced. We point out that the quantum equations of motion in canonical form for a system with singular Lagrangian differ from the classical ones whether Dirac's conjecture holds true or not. Applications of the present formulation to the Abelian and non-Abelian gauge theories are given. The expressions for PCAC and generalized PCAC of the AVV vertex are derived exactly from another point of view. A new form of the Ward identity for gauge-ghost proper vertices is obtained which differs from the usual Ward-Takahashi identity arising from the BRS invariance

Canonical transformations in problems of quantum statistical mechanics

International Nuclear Information System (INIS)

Sankovich, D.P.

1985-01-01

The problem of general canonical transformations in quantum systems possessing a classical analog is considered. The main role plays the Weyl representation of dynamic variables of the quantum system considered. One managed to build a general diagram of canonical transformations in a quantum case and to develop a method for reducing one or another operator to the simplest canonical form. In this case the procedure, being analogous to the Poincare-Birkhof normalization based on the Lie series theory, occurs

The Resurrection of Jesus: do extra-canonical sources change the landscape?

Directory of Open Access Journals (Sweden)

F P Viljoen

2005-10-01

Full Text Available The resurrection of Jesus is assumed by the New Testament to be a historical event. Some scholars argue, however, that there was no empty tomb, but that the New Testament accounts are midrashic or mythological stories about Jesus.� In this article extra-canonical writings are investigated to find out what light it may throw on intra-canonical tradition. Many extra-canonical texts seemingly have no knowledge of the passion and resurrection, and such traditions may be earlier than the intra-canonical traditions. Was the resurrection a later invention?� Are intra-canonical texts developments of extra-canonical tradition, or vice versa?� This article demonstrates that extra-canonical texts do not materially alter the landscape of enquiry.

Pair natural orbital and canonical coupled cluster reaction enthalpies involving light to heavy alkali and alkaline earth metals: the importance of sub-valence correlation.

Science.gov (United States)

Minenkov, Yury; Bistoni, Giovanni; Riplinger, Christoph; Auer, Alexander A; Neese, Frank; Cavallo, Luigi

2017-04-05

In this work, we tested canonical and domain based pair natural orbital coupled cluster methods (CCSD(T) and DLPNO-CCSD(T), respectively) for a set of 32 ligand exchange and association/dissociation reaction enthalpies involving ionic complexes of Li, Be, Na, Mg, Ca, Sr, Ba and Pb(ii). Two strategies were investigated: in the former, only valence electrons were included in the correlation treatment, giving rise to the computationally very efficient FC (frozen core) approach; in the latter, all non-ECP electrons were included in the correlation treatment, giving rise to the AE (all electron) approach. Apart from reactions involving Li and Be, the FC approach resulted in non-homogeneous performance. The FC approach leads to very small errors (correlation effects. These large errors are reduced to a few kcal mol -1 if the AE approach is used or the sub-valence orbitals of metals are included in the correlation treatment. On the technical side, the CCSD(T) and DLPNO-CCSD(T) results differ by a fraction of kcal mol -1 , indicating the latter method as the perfect choice when the CPU efficiency is essential. For completely black-box applications, as requested in catalysis or thermochemical calculations, we recommend the DLPNO-CCSD(T) method with all electrons that are not covered by effective core potentials included in the correlation treatment and correlation-consistent polarized core valence basis sets of cc-pwCVQZ(-PP) quality.

Automated invariant alignment to improve canonical variates in image fusion of satellite and weather radar data

DEFF Research Database (Denmark)

Vestergaard, Jacob Schack; Nielsen, Allan Aasbjerg

2013-01-01

Canonical correlation analysis (CCA) maximizes correlation between two sets of multivariate data. We applied CCA to multivariate satellite data and univariate radar data in order to produce a subspace descriptive of heavily precipitating clouds. A misalignment, inherent to the nature of the two...... data sets, was observed, corrupting the subspace. A method for aligning the two data sets is proposed, in order to overcome this issue and render a useful subspace projection. The observed corruption of the subspace gives rise to the hypothesis that the optimal correspondence, between a heavily...... precipitating cloud in the radar data and the associated cloud top registered in the satellite data, is found by a scale, rotation and translation invariant transformation together with a temporal displacement. The method starts by determining a conformal transformation of the radar data at the time of maximum...

Active Shape Analysis of Mandibular Growth

DEFF Research Database (Denmark)

Hilger, Klaus Baggesen; Larsen, Rasmus; Kreiborg, Sven

2003-01-01

This work contains a clinical validation using biological landmarks of a Geometry Constrained Diffusion registration of mandibular surfaces. Canonical Correlations Analysis is extended to analyse 3D landmarks and the correlations are used as similarity measures for landmark clustering. A novel Ac...

Multivariate analysis of meat production traits in Murciano-Granadina goat kids.

Science.gov (United States)

Zurita-Herrera, P; Delgado, J V; Argüello, A; Camacho, M E

2011-07-01

Growth, carcass quality, and meat quality data from Murciano-Granadina kids (n=61) raised under three different systems were collected. Canonical discriminatory analysis and cluster analysis of the entire meat production process and its stages were performed using the rearing systems as grouping criteria. All comparisons resulted in significant differences and indicated the existence of three products with different quality characteristics as a result of the three rearing systems. Differences among groups were greater when comparing carcass and meat qualities as compared with growth differences. The paired analyses of canonical correlations among groups of variables integrated in growth, carcass and meat quality, resulted in all being statistically significant, pointing out the canonical correlation coefficient between carcass quality and meat quality. Copyright © 2011 Elsevier Ltd. All rights reserved.

Catechistic Teaching, National Canons, and the Regimentation of Students' Voice

Science.gov (United States)

Kroon, Sjaak

2013-01-01

Drawing on key incident analysis of classroom transcripts from Bashkortostan, France, North Korea, and Suriname, this article discusses the relationship between an increasingly canonical content of education and the discursive organization of teaching processes at the expense of both teachers' and students' voice. It argues that canonical…

Contextuality in canonical systems of random variables

Science.gov (United States)

Dzhafarov, Ehtibar N.; Cervantes, Víctor H.; Kujala, Janne V.

2017-10-01

Random variables representing measurements, broadly understood to include any responses to any inputs, form a system in which each of them is uniquely identified by its content (that which it measures) and its context (the conditions under which it is recorded). Two random variables are jointly distributed if and only if they share a context. In a canonical representation of a system, all random variables are binary, and every content-sharing pair of random variables has a unique maximal coupling (the joint distribution imposed on them so that they coincide with maximal possible probability). The system is contextual if these maximal couplings are incompatible with the joint distributions of the context-sharing random variables. We propose to represent any system of measurements in a canonical form and to consider the system contextual if and only if its canonical representation is contextual. As an illustration, we establish a criterion for contextuality of the canonical system consisting of all dichotomizations of a single pair of content-sharing categorical random variables. This article is part of the themed issue `Second quantum revolution: foundational questions'.

THE TOPOLOGY OF CANONICAL FLUX TUBES IN FLARED JET GEOMETRY

Energy Technology Data Exchange (ETDEWEB)

Lavine, Eric Sander; You, Setthivoine, E-mail: Slavine2@uw.edu, E-mail: syou@aa.washington.edu [University of Washington, 4000 15th Street, NE Aeronautics and Astronautics 211 Guggenheim Hall, Box 352400, Seattle, WA 98195 (United States)

2017-01-20

Magnetized plasma jets are generally modeled as magnetic flux tubes filled with flowing plasma governed by magnetohydrodynamics (MHD). We outline here a more fundamental approach based on flux tubes of canonical vorticity, where canonical vorticity is defined as the circulation of the species’ canonical momentum. This approach extends the concept of magnetic flux tube evolution to include the effects of finite particle momentum and enables visualization of the topology of plasma jets in regimes beyond MHD. A flared, current-carrying magnetic flux tube in an ion-electron plasma with finite ion momentum is thus equivalent to either a pair of electron and ion flow flux tubes, a pair of electron and ion canonical momentum flux tubes, or a pair of electron and ion canonical vorticity flux tubes. We examine the morphology of all these flux tubes for increasing electrical currents, different radial current profiles, different electron Mach numbers, and a fixed, flared, axisymmetric magnetic geometry. Calculations of gauge-invariant relative canonical helicities track the evolution of magnetic, cross, and kinetic helicities in the system, and show that ion flow fields can unwind to compensate for an increasing magnetic twist. The results demonstrate that including a species’ finite momentum can result in a very long collimated canonical vorticity flux tube even if the magnetic flux tube is flared. With finite momentum, particle density gradients must be normal to canonical vorticities, not to magnetic fields, so observations of collimated astrophysical jets could be images of canonical vorticity flux tubes instead of magnetic flux tubes.

Non-canonical autophagy: an exception or an underestimated form of autophagy?

Science.gov (United States)

Scarlatti, Francesca; Maffei, Roberta; Beau, Isabelle; Ghidoni, Riccardo; Codogno, Patrice

2008-11-01

Macroautophagy (hereafter called autophagy) is a dynamic and evolutionarily conserved process used to sequester and degrade cytoplasm and entire organelles in a sequestering vesicle with a double membrane, known as the autophagosome, which ultimately fuses with a lysosome to degrade its autophagic cargo. Recently, we have unraveled two distinct forms of autophagy in cancer cells, which we term canonical and non-canonical autophagy. In contrast to classical or canonical autophagy, non-canonical autophagy is a process that does not require the entire set of autophagy-related (Atg) proteins in particular Beclin 1, to form the autophagosome. Non-canonical autophagy is therefore not blocked by the knockdown of Beclin 1 or of its binding partner hVps34. Moreover overexpression of Bcl-2, which is known to block canonical starvation-induced autophagy by binding to Beclin 1, is unable to reverse the non-canonical autophagy triggered by the polyphenol resveratrol in the breast cancer MCF-7 cell line. In MCF-7 cells, at least, non-canonical autophagy is involved in the caspase-independent cell death induced by resveratrol.

Symmetric minimally entangled typical thermal states, grand-canonical ensembles, and the influence of the collapse bases

Science.gov (United States)

Binder, Moritz; Barthel, Thomas

Based on DMRG, strongly correlated quantum many-body systems at finite temperatures can be simulated by sampling over a certain class of pure matrix product states (MPS) called minimally entangled typical thermal states (METTS). Here, we show how symmetries of the system can be exploited to considerably reduce computation costs in the METTS algorithm. While this is straightforward for the canonical ensemble, we introduce a modification of the algorithm to efficiently simulate the grand-canonical ensemble under utilization of symmetries. In addition, we construct novel symmetry-conserving collapse bases for the transitions in the Markov chain of METTS that improve the speed of convergence of the algorithm by reducing autocorrelations.

The Current Canon in British Romantics Studies.

Science.gov (United States)

Linkin, Harriet Kramer

1991-01-01

Describes and reports on a survey of 164 U.S. universities to ascertain what is taught as the current canon of British Romantic literature. Asserts that the canon may now include Mary Shelley with the former standard six major male Romantic poets, indicating a significant emergence of a feminist perspective on British Romanticism in the classroom.…

Moving Targets: Constructing Canons, 2013–2014

OpenAIRE

Hirsch, BD

2015-01-01

This review essay considers early modern dramatic authorship and canons in the context of two recent publications: an anthology of plays -- William Shakespeare and Others: Collaborative Plays (2013), edited by Jonathan Bate and Eric Rasmussen as a companion volume to the RSC Complete Works -- and a monograph study -- Jeremy Lopez's Constructing the Canon of Early Modern Drama (2014).

Canonical Least-Squares Monte Carlo Valuation of American Options: Convergence and Empirical Pricing Analysis

Directory of Open Access Journals (Sweden)

Xisheng Yu

2014-01-01

Full Text Available The paper by Liu (2010 introduces a method termed the canonical least-squares Monte Carlo (CLM which combines a martingale-constrained entropy model and a least-squares Monte Carlo algorithm to price American options. In this paper, we first provide the convergence results of CLM and numerically examine the convergence properties. Then, the comparative analysis is empirically conducted using a large sample of the S&P 100 Index (OEX puts and IBM puts. The results on the convergence show that choosing the shifted Legendre polynomials with four regressors is more appropriate considering the pricing accuracy and the computational cost. With this choice, CLM method is empirically demonstrated to be superior to the benchmark methods of binominal tree and finite difference with historical volatilities.

The canonical ensemble redefined - 1: Formalism

International Nuclear Information System (INIS)

Venkataraman, R.

1984-12-01

For studying the thermodynamic properties of systems we propose an ensemble that lies in between the familiar canonical and microcanonical ensembles. We point out the transition from the canonical to microcanonical ensemble and prove from a comparative study that all these ensembles do not yield the same results even in the thermodynamic limit. An investigation of the coupling between two or more systems with these ensembles suggests that the state of thermodynamical equilibrium is a special case of statistical equilibrium. (author)

Non‐Canonical Replication Initiation: You’re Fired!

Directory of Open Access Journals (Sweden)

Bazilė Ravoitytė

2017-01-01

Full Text Available The division of prokaryotic and eukaryotic cells produces two cells that inherit a perfect copy of the genetic material originally derived from the mother cell. The initiation of canonical DNA replication must be coordinated to the cell cycle to ensure the accuracy of genome duplication. Controlled replication initiation depends on a complex interplay of cis‐acting DNA sequences, the so‐called origins of replication (ori, with trans‐acting factors involved in the onset of DNA synthesis. The interplay of cis‐acting elements and trans‐acting factors ensures that cells initiate replication at sequence‐specific sites only once, and in a timely order, to avoid chromosomal endoreplication. However, chromosome breakage and excessive RNA:DNA hybrid formation can cause breakinduced (BIR or transcription‐initiated replication (TIR, respectively. These non‐canonical replication events are expected to affect eukaryotic genome function and maintenance, and could be important for genome evolution and disease development. In this review, we describe the difference between canonical and non‐canonical DNA replication, and focus on mechanistic differences and common features between BIR and TIR. Finally, we discuss open issues on the factors and molecular mechanisms involved in TIR.

Enabling grand-canonical Monte Carlo: extending the flexibility of GROMACS through the GromPy python interface module.

Science.gov (United States)

Pool, René; Heringa, Jaap; Hoefling, Martin; Schulz, Roland; Smith, Jeremy C; Feenstra, K Anton

2012-05-05

We report on a python interface to the GROMACS molecular simulation package, GromPy (available at https://github.com/GromPy). This application programming interface (API) uses the ctypes python module that allows function calls to shared libraries, for example, written in C. To the best of our knowledge, this is the first reported interface to the GROMACS library that uses direct library calls. GromPy can be used for extending the current GROMACS simulation and analysis modes. In this work, we demonstrate that the interface enables hybrid Monte-Carlo/molecular dynamics (MD) simulations in the grand-canonical ensemble, a simulation mode that is currently not implemented in GROMACS. For this application, the interplay between GromPy and GROMACS requires only minor modifications of the GROMACS source code, not affecting the operation, efficiency, and performance of the GROMACS applications. We validate the grand-canonical application against MD in the canonical ensemble by comparison of equations of state. The results of the grand-canonical simulations are in complete agreement with MD in the canonical ensemble. The python overhead of the grand-canonical scheme is only minimal. Copyright © 2012 Wiley Periodicals, Inc.

Interrelations between different canonical descriptions of dissipative systems

International Nuclear Information System (INIS)

Schuch, D; Guerrero, J; López-Ruiz, F F; Aldaya, V

2015-01-01

There are many approaches for the description of dissipative systems coupled to some kind of environment. This environment can be described in different ways; only effective models are being considered here. In the Bateman model, the environment is represented by one additional degree of freedom and the corresponding momentum. In two other canonical approaches, no environmental degree of freedom appears explicitly, but the canonical variables are connected with the physical ones via non-canonical transformations. The link between the Bateman approach and those without additional variables is achieved via comparison with a canonical approach using expanding coordinates, as, in this case, both Hamiltonians are constants of motion. This leads to constraints that allow for the elimination of the additional degree of freedom in the Bateman approach. These constraints are not unique. Several choices are studied explicitly, and the consequences for the physical interpretation of the additional variable in the Bateman model are discussed. (paper)

Interrelations between different canonical descriptions of dissipative systems

Science.gov (United States)

Schuch, D.; Guerrero, J.; López-Ruiz, F. F.; Aldaya, V.

2015-04-01

There are many approaches for the description of dissipative systems coupled to some kind of environment. This environment can be described in different ways; only effective models are being considered here. In the Bateman model, the environment is represented by one additional degree of freedom and the corresponding momentum. In two other canonical approaches, no environmental degree of freedom appears explicitly, but the canonical variables are connected with the physical ones via non-canonical transformations. The link between the Bateman approach and those without additional variables is achieved via comparison with a canonical approach using expanding coordinates, as, in this case, both Hamiltonians are constants of motion. This leads to constraints that allow for the elimination of the additional degree of freedom in the Bateman approach. These constraints are not unique. Several choices are studied explicitly, and the consequences for the physical interpretation of the additional variable in the Bateman model are discussed.

Canonic FFT flow graphs for real-valued even/odd symmetric inputs

Science.gov (United States)

Lao, Yingjie; Parhi, Keshab K.

2017-12-01

Canonic real-valued fast Fourier transform (RFFT) has been proposed to reduce the arithmetic complexity by eliminating redundancies. In a canonic N-point RFFT, the number of signal values at each stage is canonic with respect to the number of signal values, i.e., N. The major advantage of the canonic RFFTs is that these require the least number of butterfly operations and only real datapaths when mapped to architectures. In this paper, we consider the FFT computation whose inputs are not only real but also even/odd symmetric, which indeed lead to the well-known discrete cosine and sine transforms (DCTs and DSTs). Novel algorithms for generating the flow graphs of canonic RFFTs with even/odd symmetric inputs are proposed. It is shown that the proposed algorithms lead to canonic structures with N/2 +1 signal values at each stage for an N-point real even symmetric FFT (REFFT) or N/2 -1 signal values at each stage for an N-point RFFT real odd symmetric FFT (ROFFT). In order to remove butterfly operations, several twiddle factor transformations are proposed in this paper. We also discuss the design of canonic REFFT for any composite length. Performances of the canonic REFFT/ROFFT are also discussed. It is shown that the flow graph of canonic REFFT/ROFFT has less number of interconnections, less butterfly operations, and less twiddle factor operations, compared to prior works.

Dictionary-Based Tensor Canonical Polyadic Decomposition

Science.gov (United States)

Cohen, Jeremy Emile; Gillis, Nicolas

2018-04-01

To ensure interpretability of extracted sources in tensor decomposition, we introduce in this paper a dictionary-based tensor canonical polyadic decomposition which enforces one factor to belong exactly to a known dictionary. A new formulation of sparse coding is proposed which enables high dimensional tensors dictionary-based canonical polyadic decomposition. The benefits of using a dictionary in tensor decomposition models are explored both in terms of parameter identifiability and estimation accuracy. Performances of the proposed algorithms are evaluated on the decomposition of simulated data and the unmixing of hyperspectral images.

Covariant canonical quantization of fields and Bohmian mechanics

International Nuclear Information System (INIS)

Nikolic, H.

2005-01-01

We propose a manifestly covariant canonical method of field quantization based on the classical De Donder-Weyl covariant canonical formulation of field theory. Owing to covariance, the space and time arguments of fields are treated on an equal footing. To achieve both covariance and consistency with standard non-covariant canonical quantization of fields in Minkowski spacetime, it is necessary to adopt a covariant Bohmian formulation of quantum field theory. A preferred foliation of spacetime emerges dynamically owing to a purely quantum effect. The application to a simple time-reparametrization invariant system and quantum gravity is discussed and compared with the conventional non-covariant Wheeler-DeWitt approach. (orig.)

Canonical formalism for relativistic dynamics

International Nuclear Information System (INIS)

Penafiel-Nava, V.M.

1982-01-01

The possibility of a canonical formalism appropriate for a dynamical theory of isolated relativistic multiparticle systems involving scalar interactions is studied. It is shown that a single time-parameter structure satisfying the requirements of Poincare invariance and simultaneity of the constituents (global tranversality) can not be derived from a homogeneous Lagrangian. The dynamics is deduced initially from a non-homogeneous but singular Lagrangian designed to accommodate the global tranversality constraints with the equaltime plane associated to the total momentum of the system. An equivalent standard Lagrangian is used to generalize the parametrization procedure which is referred to an arbitrary geodesic in Minkowski space. The equations of motion and the definition of center of momentum are invariant with respect to the choice of geodesic and the entire formalism becomes separable. In the original 8N-dimensional phase-space, the symmetries of the Lagrangian give rise to a canonical realization of a fifteen-generator Lie algebra which is projected in the 6N dimensional hypersurface of dynamical motions. The time-component of the total momentum is thus reduced to a neutral element and the canonical Hamiltonian survives as the only generator for time-translations so that the no-interaction theorem becomes inapplicable

LCPT: a program for finding linear canonical transformations

International Nuclear Information System (INIS)

Char, B.W.; McNamara, B.

1979-01-01

This article describes a MACSYMA program to compute symbolically a canonical linear transformation between coordinate systems. The difficulties in implementation of this canonical small physics problem are also discussed, along with the implications that may be drawn from such difficulties about widespread MACSYMA usage by the community of computational/theoretical physicists

Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling

International Nuclear Information System (INIS)

Peng Sha; Miao Chenglin; Li Jing; Fan Xiujun; Cao Yujing; Duan Enkui

2006-01-01

Placental choriocarcinoma, a reproductive system carcinoma in women, has about 0.81% occurrence frequency in China, which leads to over 90% lethality due to indistinct pathogenesis and the absence of efficient therapeutic treatment. In the present study, using immunostaining and reverse transcription PCR, we reported that Dickkopf-1 (Dkk-1) is prominently expressed in human cytotrophoblast (CTB) cell, but absent in the human placental choriocarcinoma cell line JAR and JEG3, implicating an unknown correlation between Dkk-1 and carcinogenesis of placental choriocarcinoma. Further, through exogenous introduction of Dkk-1, we found repressed proliferation in JAR and JEG3, induced apoptosis in JAR, and discovered significant tumor suppression effects of Dkk-1 in placental choriocarcinoma. Moreover we found that this function of Dkk-1 is achieved through c-Jun N-terminal kinase (JNK), whereas the canonical Wnt pathway may not have a great role. This discovery is not symphonic to previous functional understanding of Dkk-1, a canonical Wnt signaling antagonist. Together, our data indicate the possible correlation between Dkk-1 and human placental choriocarcinoma and suggest potential applications of Dkk-1 in treatment of human placental choriocarcinomas

Taylor-expansion Monte Carlo simulations of classical fluids in the canonical and grand canonical ensemble

International Nuclear Information System (INIS)

Schoen, M.

1995-01-01

In this article the Taylor-expansion method is introduced by which Monte Carlo (MC) simulations in the canonical ensemble can be speeded up significantly, Substantial gains in computational speed of 20-40% over conventional implementations of the MC technique are obtained over a wide range of densities in homogeneous bulk phases. The basic philosophy behind the Taylor-expansion method is a division of the neighborhood of each atom (or molecule) into three different spatial zones. Interactions between atoms belonging to each zone are treated at different levels of computational sophistication. For example, only interactions between atoms belonging to the primary zone immediately surrounding an atom are treated explicitly before and after displacement. The change in the configurational energy contribution from secondary-zone interactions is obtained from the first-order term of a Taylor expansion of the configurational energy in terms of the displacement vector d. Interactions with atoms in the tertiary zone adjacent to the secondary zone are neglected throughout. The Taylor-expansion method is not restricted to the canonical ensemble but may be employed to enhance computational efficiency of MC simulations in other ensembles as well. This is demonstrated for grand canonical ensemble MC simulations of an inhomogeneous fluid which can be performed essentially on a modern personal computer

Canonical simulations with worldlines: An exploratory study in ϕ24 lattice field theory

Science.gov (United States)

Orasch, Oliver; Gattringer, Christof

2018-01-01

In this paper, we explore the perspectives for canonical simulations in the worldline formulation of a lattice field theory. Using the charged ϕ4 field in two dimensions as an example, we present the details of the canonical formulation based on worldlines and outline the algorithmic strategies for canonical worldline simulations. We discuss the steps for converting the data from the canonical approach to the grand canonical picture which we use for cross-checking our results. The canonical approach presented here can easily be generalized to other lattice field theories with a worldline representation.

Canonical and non-canonical barriers facing antimiR cancer therapeutics.

Science.gov (United States)

Cheng, Christopher J; Saltzman, W Mark; Slack, Frank J

2013-01-01

Once considered genetic "oddities", microRNAs (miRNAs) are now recognized as key epigenetic regulators of numerous biological processes, including some with a causal link to the pathogenesis, maintenance, and treatment of cancer. The crux of small RNA-based therapeutics lies in the antagonism of potent cellular targets; the main shortcoming of the field in general, lies in ineffective delivery. Inhibition of oncogenic miRNAs is a relatively nascent therapeutic concept, but as with predecessor RNA-based therapies, success hinges on delivery efficacy. This review will describes the canonical (e.g. pharmacokinetics and clearance, cellular uptake, endosome escape, etc.) and non-canonical (e.g. spatial localization and accessibility of miRNA, technical limitations of miRNA inhibition, off-target impacts, etc.) challenges to the delivery of antisense-based anti-miRNA therapeutics (i.e. antimiRs) for the treatment of cancer. Emphasis will be placed on how the current leading antimiR platforms-ranging from naked chemically modified oligonucleotides to nanoscale delivery vehicles-are affected by and overcome these barriers. The perplexity of antimiR delivery presents both engineering and biological hurdles that must be overcome in order to capitalize on the extensive pharmacological benefits of antagonizing tumor-associated miRNAs.

Identification of genome-wide non-canonical spliced regions and analysis of biological functions for spliced sequences using Read-Split-Fly.

Science.gov (United States)

Bai, Yongsheng; Kinne, Jeff; Ding, Lizhong; Rath, Ethan C; Cox, Aaron; Naidu, Siva Dharman

2017-10-03

It is generally thought that most canonical or non-canonical splicing events involving U2- and U12 spliceosomes occur within nuclear pre-mRNAs. However, the question of whether at least some U12-type splicing occurs in the cytoplasm is still unclear. In recent years next-generation sequencing technologies have revolutionized the field. The "Read-Split-Walk" (RSW) and "Read-Split-Run" (RSR) methods were developed to identify genome-wide non-canonical spliced regions including special events occurring in cytoplasm. As the significant amount of genome/transcriptome data such as, Encyclopedia of DNA Elements (ENCODE) project, have been generated, we have advanced a newer more memory-efficient version of the algorithm, "Read-Split-Fly" (RSF), which can detect non-canonical spliced regions with higher sensitivity and improved speed. The RSF algorithm also outputs the spliced sequences for further downstream biological function analysis. We used open access ENCODE project RNA-Seq data to search spliced intron sequences against the U12-type spliced intron sequence database to examine whether some events could occur as potential signatures of U12-type splicing. The check was performed by searching spliced sequences against 5'ss and 3'ss sequences from the well-known orthologous U12-type spliceosomal intron database U12DB. Preliminary results of searching 70 ENCODE samples indicated that the presence of 5'ss with U12-type signature is more frequent than U2-type and prevalent in non-canonical junctions reported by RSF. The selected spliced sequences have also been further studied using miRBase to elucidate their functionality. Preliminary results from 70 samples of ENCODE datasets show that several miRNAs are prevalent in studied ENCODE samples. Two of these are associated with many diseases as suggested in the literature. Specifically, hsa-miR-1273 and hsa-miR-548 are associated with many diseases and cancers. Our RSF pipeline is able to detect many possible junctions

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

Directory of Open Access Journals (Sweden)

Marina Pasca di Magliano

2007-11-01

Full Text Available Pancreatic ductal adenocarcinoma (PDA is an extremely aggressive malignancy, which carries a dismal prognosis. Activating mutations of the Kras gene are common to the vast majority of human PDA. In addition, recent studies have demonstrated that embryonic signaling pathway such as Hedgehog and Notch are inappropriately upregulated in this disease. The role of another embryonic signaling pathway, namely the canonical Wnt cascade, is still controversial. Here, we use gene array analysis as a platform to demonstrate general activation of the canonical arm of the Wnt pathway in human PDA. Furthermore, we provide evidence for Wnt activation in mouse models of pancreatic cancer. Our results also indicate that Wnt signaling might be activated downstream of Hedgehog signaling, which is an early event in PDA evolution. Wnt inhibition blocked proliferation and induced apoptosis of cultured adenocarcinoma cells, thereby providing evidence to support the development of novel therapeutical strategies for Wnt inhibition in pancreatic adenocarcinoma.

Escort entropies and divergences and related canonical distribution

International Nuclear Information System (INIS)

Bercher, J.-F.

2011-01-01

We discuss two families of two-parameter entropies and divergences, derived from the standard Renyi and Tsallis entropies and divergences. These divergences and entropies are found as divergences or entropies of escort distributions. Exploiting the nonnegativity of the divergences, we derive the expression of the canonical distribution associated to the new entropies and a observable given as an escort-mean value. We show that this canonical distribution extends, and smoothly connects, the results obtained in nonextensive thermodynamics for the standard and generalized mean value constraints. -- Highlights: → Two-parameter entropies are derived from q-entropies and escort distributions. → The related canonical distribution is derived. → This connects and extends known results in nonextensive statistics.

Canonical quantization of gravity and a problem of scattering

International Nuclear Information System (INIS)

Rubakov, V.A.

1980-01-01

Linearized theory of gravity is quantized both in a naive way and as a proper limit of the Dirac-Wheeler-De Witt approach to the quantization of the full theory. The equivalence between the two approaches is established. The problem of scattering in the canonically quantized theory of gravitation is investigated. The concept of the background metric naturally appears in the canonical formalism for this case. The equivalence between canonical and path-integral approaches is established for the problem of scattering. Some kinetical properties of functionals in Wheeler superspace are studied in an appendix. (author)

Quasiperiodic canonical-cell tiling with pseudo icosahedral symmetry

Science.gov (United States)

Fujita, Nobuhisa

2017-10-01

Icosahedral quasicrystals and their approximants are generally described as packing of icosahedral clusters. Experimental studies show that clusters in various approximants are orderly arranged, such that their centers are located at the nodes (or vertices) of a periodic tiling composed of four basic polyhedra called the canonical cells. This so called canonical-cell geometry is likely to serve as a common framework for modeling how clusters are arranged in approximants, while its applicability seems to extend naturally to icosahedral quasicrystals. To date, however, it has not been proved yet if the canonical cells can tile the space quasiperiodically, though we usually believe that clusters in icosahedral quasicrystals are arranged such that quasiperiodic long-range order as well as icosahedral point symmetry is maintained. In this paper, we report for the first time an iterative geometrical transformation of the canonical cells defining a so-called substitution rule, which we can use to generate a class of quasiperiodic canonical-cell tilings. Every single step of the transformation proceeds as follows: each cell is first enlarged by a magnification ratio of τ3 (τ = golden mean) and then subdivided into cells of the original size. Here, cells with an identical shape can be subdivided in several distinct manners depending on how their adjacent neighbors are arranged, and sixteen types of cells are identified in terms of unique subdivision. This class of quasiperiodic canonical-cell tilings presents the first realization of three-dimensional quasiperiodic tilings with fractal atomic surfaces. There are four distinct atomic surfaces associated with four sub-modules of the primitive icosahedral module, where a representative of the four submodules corresponds to the Σ = 4 coincidence site module of the icosahedral module. It follows that the present quasiperiodic tilings involve a kind of superlattice ordering that manifests itself in satellite peaks in the

The application of the TRAC-PD2 code in the CANON experiment

International Nuclear Information System (INIS)

Neves Conti, T. das; Freitas, R.L.

1991-09-01

The TRAC code (Transient Reactor Analysis Code), developed in the Los Alamos National Laboratory, is used to accident analysis in light water reactor. The TRAC-PD2 version, used in this paper, has a refined dynamic flow model for two fluids, which is based on the conservation equations of mass, momentum and energy for liquid and vapor, allowing then a mechanical and thermal unbalance between phases. This paper presents a comparison of the TRAC-PD2 code with the CANON experiment, which simulates a Loss of Coolant Accident (LOCA) by depressurizing a horizontal tube filled with water at different temperatures. The experiment consists in a instantaneous rupture in one of the tube's edge, taking measures of pressure and void fraction during the transient. The TRAC-PD2 code results are in a good agreement with the pressure and void fraction evolution obtained in the CANON experiment. (author)

A canonical-literary reading of Lamentations 5

Directory of Open Access Journals (Sweden)

Shinman Kang

2009-08-01

Full Text Available This article presents a canonical and literary reading of Lamentations 5 in the context of the book of Lamentations as a whole. Following the approach by Vanhoozer (1998, 2002 based on speech-act theory, the meaning of Scripture is sought at canonical level, supervening the basic literary level. In Lamentations, as polyphonic poetic text, the speaking voices form a very important key for the interpretation of the text. In the polyphonic text of Lamentations, the shifting of the speaking voices occurs between Lamentations 1 and 4. Lamentations 5 is monologic. The theories of Bakhtin (1984 are also used to understand the book of Lamentations. In this book, chapter 5 forms the climax where Jerusalem cries to God. We cannot, however, find God’s answer to this call in Lamentations; we can find it only within the broader text of the Christian canon.

Unified correspondence and canonicity

NARCIS (Netherlands)

Zhao, Z.

2018-01-01

Correspondence theory originally arises as the study of the relation between modal formulas and first-order formulas interpreted over Kripke frames. We say that a modal formula and a first-order formula correspond to each other if they are valid on the same class of Kripke frames. Canonicity theory

Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures

International Nuclear Information System (INIS)

Hirsch, Cordula; Campano, Louise M.; Woehrle, Simon; Hecht, Andreas

2007-01-01

Canonical Wnt signaling triggers the formation of heterodimeric transcription factor complexes consisting of β-catenin and T cell factors, and thereby controls the execution of specific genetic programs. During the expansion and neurogenic phases of embryonic neural development canonical Wnt signaling initially controls proliferation of neural progenitor cells, and later neuronal differentiation. Whether Wnt growth factors affect neural progenitor cells postnatally is not known. Therefore, we have analyzed the impact of Wnt signaling on neural progenitors isolated from cerebral cortices of newborn mice. Expression profiling of pathway components revealed that these cells are fully equipped to respond to Wnt signals. However, Wnt pathway activation affected only a subset of neonatal progenitors and elicited a limited increase in proliferation and neuronal differentiation in distinct subsets of cells. Moreover, Wnt pathway activation only transiently stimulated S-phase entry but did not support long-term proliferation of progenitor cultures. The dampened nature of the Wnt response correlates with the predominant expression of inhibitory pathway components and the rapid actuation of negative feedback mechanisms. Interestingly, in differentiating cell cultures activation of canonical Wnt signaling reduced Hes1 and Hes5 expression suggesting that during postnatal neural development, Wnt/β-catenin signaling enhances neurogenesis from progenitor cells by interfering with Notch pathway activity

S-matrix equivalence theorem evasion and dimensional regularisation with the canonical MHV lagrangian

International Nuclear Information System (INIS)

Ettle, James H.; Fu, C.-H.; Fudger, Jonathan P.; Mansfield, Paul R.W.; Morris, Tim R.

2007-01-01

We demonstrate that the canonical change of variables that yields the MHV lagrangian, also provides contributions to scattering amplitudes that evade the equivalence theorem. This 'ET evasion' in particular provides the tree-level (-++) amplitude, which is non-vanishing off shell, or on shell with complex momenta or in (2,2) signature, and is missing from the MHV (/aka CSW) rules. At one loop there are ET-evading diagrammatic contributions to the amplitudes with all positive helicities. We supply the necessary regularisation in order to define these contributions (and quantum MHV methods in general) by starting from the light-cone Yang-Mills lagrangian in D dimensions and making a canonical change of variables for all D-2 transverse degrees of freedom of the gauge field. In this way, we obtain dimensionally regularised three- and four-point MHV amplitudes. Returning to the one-loop (++++) amplitude, we demonstrate that its quadruple cut coincides with the known result, and show how the original light-cone Yang-Mills contributions can in fact be algebraically recovered from the ET-evading contributions. We conclude that the canonical MHV lagrangian, supplemented with the extra terms brought to correlation functions by the non-linear field transformation, provide contributions which are just a rearrangement of those from light-cone Yang-Mills and thus coincide with them both on and off shell

Canonical Quantum Teleportation of Two-Particle Arbitrary State

Institute of Scientific and Technical Information of China (English)

HAO Xiang; ZHU Shi-Qun

2005-01-01

The canonical quantum teleportation of two-particle arbitrary state is realized by means of phase operator and number operator. The maximally entangled eigenstates between the difference of phase operators and the sum of number operators are considered as the quantum channels. In contrast to the standard quantum teleportation, the different unitary local operation of canonical teleportation can be simplified by a general expression.

Canonical sectors of five-dimensional Chern-Simons theories

International Nuclear Information System (INIS)

Miskovic, Olivera; Troncoso, Ricardo; Zanelli, Jorge

2005-01-01

The dynamics of five-dimensional Chern-Simons theories is analyzed. These theories are characterized by intricate self couplings which give rise to dynamical features not present in standard theories. As a consequence, Dirac's canonical formalism cannot be directly applied due to the presence of degeneracies of the symplectic form and irregularities of the constraints on some surfaces of phase space, obscuring the dynamical content of these theories. Here we identify conditions that define sectors where the canonical formalism can be applied for a class of non-Abelian Chern-Simons theories, including supergravity. A family of solutions satisfying the canonical requirements is explicitly found. The splitting between first and second class constraints is performed around these backgrounds, allowing the construction of the charge algebra, including its central extension

Spin glass transition in canonical AuFe alloys: A numerical study

International Nuclear Information System (INIS)

Zhang, Kai-Cheng; Li, Yong-Feng; Liu, Gui-Bin; Zhu, Yan

2012-01-01

Although spin glass transitions have long been observed in diluted magnetic alloys, e.g. AuFe and CuMn alloys, previous numerical studies are not completely consistent with the experiment results. The abnormal critical exponents of the alloys remain still puzzling. By employing parallel tempering algorithm with finite-size scaling analysis, we investigated the phase transitions in canonical AuFe alloys. Our results strongly support that spin glass transitions occur at finite temperatures in the alloys. The calculated critical exponents agree well with those obtained from experiments. -- Highlights: ► By simulation we investigated the abnormal critical exponents observed in canonical SG alloys. ► The critical exponents obtained from our simulations agree well with those measured from experiments. ► Our results strongly support that RKKY interactions lead to SG transitions at finite temperatures.

Pair natural orbital and canonical coupled cluster reaction enthalpies involving light to heavy alkali and alkaline earth metals: the importance of sub-valence correlation

KAUST Repository

Minenkov, Yury

2017-03-07

In this work, we tested canonical and domain based pair natural orbital coupled cluster methods (CCSD(T) and DLPNO-CCSD(T), respectively) for a set of 32 ligand exchange and association/dissociation reaction enthalpies involving ionic complexes of Li, Be, Na, Mg, Ca, Sr, Ba and Pb(ii). Two strategies were investigated: in the former, only valence electrons were included in the correlation treatment, giving rise to the computationally very efficient FC (frozen core) approach; in the latter, all non-ECP electrons were included in the correlation treatment, giving rise to the AE (all electron) approach. Apart from reactions involving Li and Be, the FC approach resulted in non-homogeneous performance. The FC approach leads to very small errors (<2 kcal mol-1) for some reactions of Na, Mg, Ca, Sr, Ba and Pb, while for a few reactions of Ca and Ba deviations up to 40 kcal mol-1 have been obtained. Large errors are both due to artificial mixing of the core (sub-valence) orbitals of metals and the valence orbitals of oxygen and halogens in the molecular orbitals treated as core, and due to neglecting core-core and core-valence correlation effects. These large errors are reduced to a few kcal mol-1 if the AE approach is used or the sub-valence orbitals of metals are included in the correlation treatment. On the technical side, the CCSD(T) and DLPNO-CCSD(T) results differ by a fraction of kcal mol-1, indicating the latter method as the perfect choice when the CPU efficiency is essential. For completely black-box applications, as requested in catalysis or thermochemical calculations, we recommend the DLPNO-CCSD(T) method with all electrons that are not covered by effective core potentials included in the correlation treatment and correlation-consistent polarized core valence basis sets of cc-pwCVQZ(-PP) quality.

Intermediate inflation from a non-canonical scalar field

Energy Technology Data Exchange (ETDEWEB)

Rezazadeh, K.; Karami, K. [Department of Physics, University of Kurdistan, Pasdaran St., Sanandaj (Iran, Islamic Republic of); Karimi, P., E-mail: rezazadeh86@gmail.com, E-mail: KKarami@uok.ac.ir, E-mail: parvin.karimi67@yahoo.com [Center for Excellence in Astronomy and Astrophysics (CEAA-RIAAM), P.O. Box 55134-441, Maragha (Iran, Islamic Republic of)

2015-09-01

We study the intermediate inflation in a non-canonical scalar field framework with a power-like Lagrangian. We show that in contrast with the standard canonical intermediate inflation, our non-canonical model is compatible with the observational results of Planck 2015. Also, we estimate the equilateral non-Gaussianity parameter which is in well agreement with the prediction of Planck 2015. Then, we obtain an approximation for the energy scale at the initial time of inflation and show that it can be of order of the Planck energy scale, i.e. M{sub P} ∼ 10{sup 18}GeV. We will see that after a short period of time, inflation enters in the slow-roll regime that its energy scale is of order M{sub P}/100 ∼ 10{sup 16}GeV and the horizon exit takes place in this energy scale. We also examine an idea in our non-canonical model to overcome the central drawback of intermediate inflation which is the fact that inflation never ends. We solve this problem without disturbing significantly the nature of the intermediate inflation until the time of horizon exit.

On the calculation of single ion activity coefficients in homogeneous ionic systems by application of the grand canonical ensemble

DEFF Research Database (Denmark)

Sloth, Peter

1993-01-01

The grand canonical ensemble has been used to study the evaluation of single ion activity coefficients in homogeneous ionic fluids. In this work, the Coulombic interactions are truncated according to the minimum image approximation, and the ions are assumed to be placed in a structureless......, homogeneous dielectric continuum. Grand canonical ensemble Monte Carlo calculation results for two primitive model electrolyte solutions are presented. Also, a formula involving the second moments of the total correlation functions is derived from fluctuation theory, which applies for the derivatives...... of the individual ionic activity coefficients with respect to the total ionic concentration. This formula has previously been proposed on the basis of somewhat different considerations....

Canonical sound speed profile for the central Bay of Bengal

Digital Repository Service at National Institute of Oceanography (India)

Murty, T.V.R.; PrasannaKumar, S.; Somayajulu, Y.K.; Sastry, J.S.; De Figueiredo, R.J.P.

Following Munk's canonical theory, an algorithm has been presented for computing sound channel parameters in the western and southern Bay of Bengal. The estimated canonical sound speed profile using these parameters has been compared with computed...

Inhibition of adipocytogenesis by canonical WNT signaling in human mesenchymal stem cells

International Nuclear Information System (INIS)

Shen, Longxiang; Glowacki, Julie; Zhou, Shuanhu

2011-01-01

The WNT signaling pathway plays important roles in the self-renewal and differentiation of mesenchymal stem cells (MSCs). Little is known about WNT signaling in adipocyte differentiation of human MSCs. In this study, we tested the hypothesis that canonical and non-canonical WNTs differentially regulate in vitro adipocytogenesis in human MSCs. The expression of adipocyte gene PPARγ2, lipoprotein lipase, and adipsin increased during adipocytogenesis of hMSCs. Simultaneously, the expression of canonical WNT2, 10B, 13, and 14 decreased, whereas non-canonical WNT4 and 11 increased, and WNT5A was unchanged. A small molecule WNT mimetic, SB-216763, increased accumulation of β-catenin protein, inhibited induction of WNT4 and 11 and inhibited adipocytogenesis. In contrast, knockdown of β-catenin with siRNA resulted in spontaneous adipocytogenesis. These findings support the view that canonical WNT signaling inhibits and non-canonical WNT signaling promotes adipocytogenesis in adult human marrow-derived mesenchymal stem cells.

Canonical partition functions: ideal quantum gases, interacting classical gases, and interacting quantum gases

Science.gov (United States)

Zhou, Chi-Chun; Dai, Wu-Sheng

2018-02-01

In statistical mechanics, for a system with a fixed number of particles, e.g. a finite-size system, strictly speaking, the thermodynamic quantity needs to be calculated in the canonical ensemble. Nevertheless, the calculation of the canonical partition function is difficult. In this paper, based on the mathematical theory of the symmetric function, we suggest a method for the calculation of the canonical partition function of ideal quantum gases, including ideal Bose, Fermi, and Gentile gases. Moreover, we express the canonical partition functions of interacting classical and quantum gases given by the classical and quantum cluster expansion methods in terms of the Bell polynomial in mathematics. The virial coefficients of ideal Bose, Fermi, and Gentile gases are calculated from the exact canonical partition function. The virial coefficients of interacting classical and quantum gases are calculated from the canonical partition function by using the expansion of the Bell polynomial, rather than calculated from the grand canonical potential.

Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development

Directory of Open Access Journals (Sweden)

Silvia Mazzotta

2016-10-01

Full Text Available Wnt signaling is a key regulator of vertebrate heart development; however, specific roles for human cardiomyocyte development remain uncertain. Here we use human embryonic stem cells (hESCs to analyze systematically in human cardiomyocyte development the expression of endogenous Wnt signaling components, monitor pathway activity, and dissect stage-specific requirements for canonical and noncanonical Wnt signaling mechanisms using small-molecule inhibitors. Our analysis suggests that WNT3 and WNT8A, via FZD7 and canonical signaling, regulate BRACHYURY expression and mesoderm induction; that WNT5A/5B, via ROR2 and noncanonical signaling, regulate MESP1 expression and cardiovascular development; and that later in development WNT2, WNT5A/5B, and WNT11, via FZD4 and FZD6, regulate functional cardiomyocyte differentiation via noncanonical Wnt signaling. Our findings confirm in human development previously proposed roles for canonical Wnt signaling in sequential stages of vertebrate cardiomyogenesis, and identify more precise roles for noncanonical signaling and for individual Wnt signal and Wnt receptor genes in human cardiomyocyte development.

A canonical-literary reading of Lamentations 5 | Kang | HTS ...

African Journals Online (AJOL)

This article presents a canonical and literary reading of Lamentations 5 in the context of the book of Lamentations as a whole. Following the approach by Vanhoozer (1998, 2002) based on speech-act theory, the meaning of Scripture is sought at canonical level, supervening the basic literary level. In Lamentations, as ...

CANONICAL RELATIONS MORPHOLOGIC FEATURES, MOTOR ABILITIES AND TESTS WITH SITACIONI BASKETBALL PLAYERS AGED 12-14 YEARS

Directory of Open Access Journals (Sweden)

Zulfo Aruković

2013-07-01

Full Text Available The aim of this istraživanjua is identifying the canonical correlation between two multidimensional space, the space of morphological characteristics and basic mo¬tor skills room, basketball od12 to 14 years of success on the result of situ¬atio¬nal-motor tests of basketball games. The study was conducted on a sample of 70 players.

Canonical basis for type A4 (II) - Polynomial elements in one variable

International Nuclear Information System (INIS)

Hu Yuwang; Ye Jiachen

2003-12-01

All the 62 monomial elements in the canonical basis B of the quantized enveloping algebra for type A 4 have been determined. According to Lusztig's idea, the elements in the canonical basis B consist of monomials and linear combinations of monomials (for convenience, we call them polynomials). In this note, we compute all the 144 polynomial elements in one variable in the canonical basis B of the quantized enveloping algebra for type A 4 based on our joint note. We conjecture that there are other polynomial elements in two or three variables in the canonical basis B, which include independent variables and dependent variables. Moreover, it is conjectured that there are no polynomial elements in the canonical basis B with four or more variables. (author)

Realizations of the canonical representation

Indian Academy of Sciences (India)

Traditionally, the canonical representation is realized on the Hilbert space ... Fix a decomposition R2n = Rn × Rn ..... to an orthonormal basis {ψ1,ψ2,. ..... [7] Vemuri M K, A non-commutative Sobolev inequality and its application to spectral.

Universal critical wrapping probabilities in the canonical ensemble

Directory of Open Access Journals (Sweden)

Hao Hu

2015-09-01

Full Text Available Universal dimensionless quantities, such as Binder ratios and wrapping probabilities, play an important role in the study of critical phenomena. We study the finite-size scaling behavior of the wrapping probability for the Potts model in the random-cluster representation, under the constraint that the total number of occupied bonds is fixed, so that the canonical ensemble applies. We derive that, in the limit L→∞, the critical values of the wrapping probability are different from those of the unconstrained model, i.e. the model in the grand-canonical ensemble, but still universal, for systems with 2yt−d>0 where yt=1/ν is the thermal renormalization exponent and d is the spatial dimension. Similar modifications apply to other dimensionless quantities, such as Binder ratios. For systems with 2yt−d≤0, these quantities share same critical universal values in the two ensembles. It is also derived that new finite-size corrections are induced. These findings apply more generally to systems in the canonical ensemble, e.g. the dilute Potts model with a fixed total number of vacancies. Finally, we formulate an efficient cluster-type algorithm for the canonical ensemble, and confirm these predictions by extensive simulations.

The canonical quantization of local scalar fields over quantum space-time

International Nuclear Information System (INIS)

Banai, M.

1983-05-01

Canonical quantization of a classical local field theory (CLFT) consisting of N real scalar fields is formulated in the Hilbert space over the sup(*)-algebra A of linear operators of L 2 (R 3 ). The canonical commutation relations (CCR) have an irreducible solution, unique up to A-unitary equivalence. The canonical equations as operator equations are equivalent to the classical (c) field equations. The interaction picture can be introduced in a well-defined manner. The main adventage of this treatment is that the corresponding S-matrix is free of divergences. The Feynman's graph technique is adaptable in a straightforward manner. This approach is a natural extension of the conventional canonical quantization method of quantum mechanics. (author)

Canonical transformations method in the potential scattering problem

International Nuclear Information System (INIS)

Pavlenko, Yu.G.

1984-01-01

Canonical formalism of the first order is used in the present paper to solve the problem of scattering and other problems of quantum mechanics. The theory of canonical transformations (CT) being the basis of hamiltonian approach permits to develop several methods of integration being beyond the scope of the standard theory of perturbations. In this case it is essential for numerical counting that the theory permits to obtain algorithm for plotting highest approximations

Nonlinear Redundancy Analysis. Research Report 88-1.

Science.gov (United States)

van der Burg, Eeke; de Leeuw, Jan

A non-linear version of redundancy analysis is introduced. The technique is called REDUNDALS. It is implemented within the computer program for canonical correlation analysis called CANALS. The REDUNDALS algorithm is of an alternating least square (ALS) type. The technique is defined as minimization of a squared distance between criterion…

Canonical Authors in Consumption Theory

DEFF Research Database (Denmark)

Canonical Authors in Consumption Theory is the first work to compile the contributions of the greatest social thinkers in the global conversation about consumption and consumer culture. A prestigious reference work, it offers original chapters by the world's most prominent thought leaders and sur...

New insights into transcription fidelity: thermal stability of non-canonical structures in template DNA regulates transcriptional arrest, pause, and slippage.

Science.gov (United States)

Tateishi-Karimata, Hisae; Isono, Noburu; Sugimoto, Naoki

2014-01-01

The thermal stability and topology of non-canonical structures of G-quadruplexes and hairpins in template DNA were investigated, and the effect of non-canonical structures on transcription fidelity was evaluated quantitatively. We designed ten template DNAs: A linear sequence that does not have significant higher-order structure, three sequences that form hairpin structures, and six sequences that form G-quadruplex structures with different stabilities. Templates with non-canonical structures induced the production of an arrested, a slipped, and a full-length transcript, whereas the linear sequence produced only a full-length transcript. The efficiency of production for run-off transcripts (full-length and slipped transcripts) from templates that formed the non-canonical structures was lower than that from the linear. G-quadruplex structures were more effective inhibitors of full-length product formation than were hairpin structure even when the stability of the G-quadruplex in an aqueous solution was the same as that of the hairpin. We considered that intra-polymerase conditions may differentially affect the stability of non-canonical structures. The values of transcription efficiencies of run-off or arrest transcripts were correlated with stabilities of non-canonical structures in the intra-polymerase condition mimicked by 20 wt% polyethylene glycol (PEG). Transcriptional arrest was induced when the stability of the G-quadruplex structure (-ΔG°37) in the presence of 20 wt% PEG was more than 8.2 kcal mol(-1). Thus, values of stability in the presence of 20 wt% PEG are an important indicator of transcription perturbation. Our results further our understanding of the impact of template structure on the transcription process and may guide logical design of transcription-regulating drugs.

CANONICAL BACKWARD DIFFERENTIATION SCHEMES FOR ...

African Journals Online (AJOL)

This paper describes a new nonlinear backward differentiation schemes for the numerical solution of nonlinear initial value problems of first order ordinary differential equations. The schemes are based on rational interpolation obtained from canonical polynomials. They are A-stable. The test problems show that they give ...

Fifth-order canonical geometric aberration analysis of electrostatic round lenses

CERN Document Server

Liu Zhi Xiong

2002-01-01

In this paper the fifth-order canonical geometric aberration patterns are analyzed and a numerical example is given on the basis of the analytical expressions of fifth-order aberration coefficients derived in the present work. The fifth-order spherical aberration, astigmatism and field curvature, and distortion are similar to the third-order ones and the fifth-order coma is slightly different. Besides, there are two more aberrations which do not exist in the third-order aberration: they are peanut aberration and elliptical coma in accordance with their shapes. In the numerical example, by using a cross-check of the calculated coefficients with those computed through the differential algebraic method, it has been verified that all the expressions are correct and the computational results are reliable with high precision.

Modern canonical quantum general relativity

CERN Document Server

Thiemann, Thomas

2007-01-01

This is an introduction to the by now fifteen years old research field of canonical quantum general relativity, sometimes called "loop quantum gravity". The term "modern" in the title refers to the fact that the quantum theory is based on formulating classical general relativity as a theory of connections rather than metrics as compared to in original version due to Arnowitt, Deser and Misner. Canonical quantum general relativity is an attempt to define a mathematically rigorous, non-perturbative, background independent theory of Lorentzian quantum gravity in four spacetime dimensions in the continuum. The approach is minimal in that one simply analyzes the logical consequences of combining the principles of general relativity with the principles of quantum mechanics. The requirement to preserve background independence has lead to new, fascinating mathematical structures which one does not see in perturbative approaches, e.g. a fundamental discreteness of spacetime seems to be a prediction of the theory provi...

Place Of Canon Law Of The Russian Empire In The System Io Humanitarian

Directory of Open Access Journals (Sweden)

Alexandra A. Dorskaya

2014-12-01

Full Text Available In the present article author examines place of canon law in the system of humanitarian sciences in the Russian Empire at the end of XVIII - early XX centuries. Author reveals interaction of canon law with philosophy, philology, jurisprudence. In particular, author shows influence of various philosophical schools on the development of the canon law science, value of foreign researches translation for the development of national science of canon law starting from the end of the XVIII century. It is found that all researchers in the field of canon law had special scientific works on philosophy. Interference of cannon law and theological science – dogmatic theology, moral theology, liturgy, church geography, chronology, statistics, history, archeology, pastoral theology is considered. In the article works of leading specialists in the field of canon law the second half of XIX - early XX centuries that were left as a significant legacy after the Archimandrite Gabriel, I.S. Berdnikova, N.A. Zaozerskii, I.M. Skvortsov and others are analyzed. In conclusion author shows complexity and urgency of the problem in the process of church (canon law study at the present stage, when there is some struggle between the secular and religious science.

Canonical forms of tensor representations and spontaneous symmetry breaking

International Nuclear Information System (INIS)

Cummins, C.J.

1986-01-01

An algorithm for constructing canonical forms for any tensor representation of the classical compact Lie groups is given. This method is used to find a complete list of the symmetry breaking patterns produced by Higgs fields in the third-rank antisymmetric representations of U(n), SU(n) and SO(n) for n<=7. A simple canonical form is also given for kth-rank symmetric tensor representations. (author)

37 CFR 10.21 - Canon 1.

Science.gov (United States)

2010-07-01

... REPRESENTATION OF OTHERS BEFORE THE PATENT AND TRADEMARK OFFICE Patent and Trademark Office Code of Professional Responsibility § 10.21 Canon 1. A practitioner should assist in maintaining the integrity and competence of the...

Romanticism, Sexuality, and the Canon.

Science.gov (United States)

Rowe, Kathleen K.

1990-01-01

Traces the Romanticism in the work and persona of film director Jean-Luc Godard. Examines the contradictions posed by Godard's politics and representations of sexuality. Asserts, that by bringing an ironic distance to the works of such canonized directors, viewers can take pleasure in those works despite their contradictions. (MM)

CERN Photo Club (CPC) / Canon Contest - My View of CERN

CERN Multimedia

Steyaert, Didier

2016-01-01

The CERN Photo Club has organized in collaboration with Canon Switzerland a photo contest open to all members of the CERN (Persons with a CERN access card). The only restriction is that the photos must have been taken with a CANON camera (DSLR, bridge or compact) between 1 and 31 October 2016.

The canonical partial metric and the uniform convexity on normed spaces

Directory of Open Access Journals (Sweden)

S. Oltra

2005-10-01

Full Text Available In this paper we introduce the notion of canonical partial metric associated to a norm to study geometric properties of normed spaces. In particular, we characterize strict convexity and uniform convexity of normed spaces in terms of the canonical partial metric defined by its norm. We prove that these geometric properties can be considered, in this sense, as topological properties that appear when we compare the natural metric topology of the space with the non translation invariant topology induced by the canonical partial metric in the normed space.

Clifford Algebras and Spinorial Representation of Linear Canonical Transformations in Quantum Theory

International Nuclear Information System (INIS)

Raoelina Andriambololona; Ranaivoson, R.T.R.; Rakotoson, H.

2017-11-01

This work is a continuation of previous works that we have done concerning linear canonical transformations and a phase space representation of quantum theory. It is mainly focused on the description of an approach which permits to establish spinorial representation of linear canonical transformations. It begins with an introduction section in which the reason and context of the content are discussed. The introduction section is followed by a brief recall about Clifford algebra and spin group. The description of the approach is started with the presentation of an adequate parameterization of linear canonical transformations which permits to represent them with special pseudo-orthogonal transformations in an operators space. The establishment of the spinorial representation is deduced using relation between special pseudo-orthogonal groups and spin groups. The cases of one dimension quantum mechanics and general multidimensional theory are both studied. The case of linear canonical transformation related to Minkowski space is particularly studied and it is shown that Lorentz transformation may be considered as particular case of linear canonical transformation. Some results from the spinorial representation are also exploited to define operators which may be used to establish equations for fields if one considers the possibility of envisaging a field theory which admits as main symmetry group the group constituted by linear canonical transformations.

Kuidas Canon suureks kasvas / Andres Eilart

Index Scriptorium Estoniae

Eilart, Andres

2004-01-01

Jaapani kaamerate ja büroomasinate tootja Canon Groupi arengust, tegevusest kolmes regioonis - USA-s, Euroopas ja Aasias ning ettevõtte pikaajalise edu põhjustest - ärifilosoofiast ning ajastatud tootearendusest. Vt. samas: Firma esialgne nimi oli Kwanon; Konkurendid koonduvad

Non-Canonical Cell Death Induced by p53

Directory of Open Access Journals (Sweden)

Atul Ranjan

2016-12-01

Full Text Available Programmed cell death is a vital biological process for multicellular organisms to maintain cellular homeostasis, which is regulated in a complex manner. Over the past several years, apart from apoptosis, which is the principal mechanism of caspase-dependent cell death, research on non-apoptotic forms of programmed cell death has gained momentum. p53 is a well characterized tumor suppressor that controls cell proliferation and apoptosis and has also been linked to non-apoptotic, non-canonical cell death mechanisms. p53 impacts these non-canonical forms of cell death through transcriptional regulation of its downstream targets, as well as direct interactions with key players involved in these mechanisms, in a cell type- or tissue context-dependent manner. In this review article, we summarize and discuss the involvement of p53 in several non-canonical modes of cell death, including caspase-independent apoptosis (CIA, ferroptosis, necroptosis, autophagic cell death, mitotic catastrophe, paraptosis, and pyroptosis, as well as its role in efferocytosis which is the process of clearing dead or dying cells.

On the relationship between modifications to the Raychaudhuri equation and the canonical Hamiltonian structures

International Nuclear Information System (INIS)

Singh, Parampreet; Soni, S K

2016-01-01

The problem of obtaining canonical Hamiltonian structures from the equations of motion, without any knowledge of the action, is studied in the context of the spatially flat Friedmann, ‘Robertson’, and Walker models. Modifications to the Raychaudhuri equation are implemented independently as quadratic and cubic terms of energy density without introducing additional degrees of freedom. Depending on their sign, modifications make gravity repulsive above a curvature scale for matter satisfying strong energy conditions, or more attractive than in the classical theory. The canonical structure of the modified theories is determined by demanding that the total Hamiltonian be a linear combination of gravity and matter Hamiltonians. In the quadratic repulsive case, the modified canonical phase space of gravity is a polymerized phase space with canonical momentum as inverse a trigonometric function of the Hubble rate; the canonical Hamiltonian can be identified with the effective Hamiltonian in loop quantum cosmology. The repulsive cubic modification results in a ‘generalized polymerized’ canonical phase space. Both the repulsive modifications are found to yield singularity avoidance. In contrast, the quadratic and cubic attractive modifications result in a canonical phase space in which canonical momentum is nontrigonometric and singularities persist. Our results hint at connections between the repulsive/attractive nature of modifications to gravity arising from the gravitational sector and polymerized/non polymerized gravitational phase space. (paper)

Base pair probability estimates improve the prediction accuracy of RNA non-canonical base pairs.

Directory of Open Access Journals (Sweden)

Michael F Sloma

2017-11-01

Full Text Available Prediction of RNA tertiary structure from sequence is an important problem, but generating accurate structure models for even short sequences remains difficult. Predictions of RNA tertiary structure tend to be least accurate in loop regions, where non-canonical pairs are important for determining the details of structure. Non-canonical pairs can be predicted using a knowledge-based model of structure that scores nucleotide cyclic motifs, or NCMs. In this work, a partition function algorithm is introduced that allows the estimation of base pairing probabilities for both canonical and non-canonical interactions. Pairs that are predicted to be probable are more likely to be found in the true structure than pairs of lower probability. Pair probability estimates can be further improved by predicting the structure conserved across multiple homologous sequences using the TurboFold algorithm. These pairing probabilities, used in concert with prior knowledge of the canonical secondary structure, allow accurate inference of non-canonical pairs, an important step towards accurate prediction of the full tertiary structure. Software to predict non-canonical base pairs and pairing probabilities is now provided as part of the RNAstructure software package.

Base pair probability estimates improve the prediction accuracy of RNA non-canonical base pairs.

Science.gov (United States)

Sloma, Michael F; Mathews, David H

2017-11-01

Prediction of RNA tertiary structure from sequence is an important problem, but generating accurate structure models for even short sequences remains difficult. Predictions of RNA tertiary structure tend to be least accurate in loop regions, where non-canonical pairs are important for determining the details of structure. Non-canonical pairs can be predicted using a knowledge-based model of structure that scores nucleotide cyclic motifs, or NCMs. In this work, a partition function algorithm is introduced that allows the estimation of base pairing probabilities for both canonical and non-canonical interactions. Pairs that are predicted to be probable are more likely to be found in the true structure than pairs of lower probability. Pair probability estimates can be further improved by predicting the structure conserved across multiple homologous sequences using the TurboFold algorithm. These pairing probabilities, used in concert with prior knowledge of the canonical secondary structure, allow accurate inference of non-canonical pairs, an important step towards accurate prediction of the full tertiary structure. Software to predict non-canonical base pairs and pairing probabilities is now provided as part of the RNAstructure software package.

Spectral analysis by correlation

International Nuclear Information System (INIS)

Fauque, J.M.; Berthier, D.; Max, J.; Bonnet, G.

1969-01-01

The spectral density of a signal, which represents its power distribution along the frequency axis, is a function which is of great importance, finding many uses in all fields concerned with the processing of the signal (process identification, vibrational analysis, etc...). Amongst all the possible methods for calculating this function, the correlation method (correlation function calculation + Fourier transformation) is the most promising, mainly because of its simplicity and of the results it yields. The study carried out here will lead to the construction of an apparatus which, coupled with a correlator, will constitute a set of equipment for spectral analysis in real time covering the frequency range 0 to 5 MHz. (author) [fr

Management of pediatric radiation dose using Canon digital radiography

International Nuclear Information System (INIS)

Arreola, M.; Rill, L.

2004-01-01

A Canon CXDI-11 digital radiography (DR) system has been in use at Shands Hospital at the University of Florida for the past 2 1/2 years. A first clinical implementation phase was utilized to develop imaging protocols for adult patients, with a second phase incorporating pediatric chest and abdominal studies a few months later. This paper describes some of the steps taken during the modality implementation stages, as well as the methodologies and procedures utilized to monitor compliance by the technologists. The Canon DR system provides the technologist with an indication of the radiation exposure received by the detector (and thus of the patient dose) by means of an indirect exposure level number called the reached exposure (REX) value. The REX value is calculated by the system based on the default grayscale curve preselected for a given anatomical view and used by the system to optimize the appearance of the image. The brightness and contrast of the image can be modified by the user at the QC/control screen for the purpose of improving the appearance of the image. Such changes modify the actual grayscale curve (position and slope, respectively) and thus the calculated REX value. Thus, undisciplined use of the brightness and contrast functions by the technologist can render the REX value meaningless as an exposure indicator. The paper also shows how it is possible to calibrate AEC (phototimer) systems for use with the Canon DR system, and utilize the REX value as a valuable dose indicator through proper training of technologists and strict, disciplined QC of studies. A team consisting of the site's medical physicist, radiologists, and technologists, as well as Canon engineers, can work together in properly calibrating and setting up the system for the purposes of monitoring patient doses (especially pediatric) in DR studies performed in a Canon DR system. (orig.)

Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses.

Science.gov (United States)

Majoros, Andrea; Platanitis, Ekaterini; Kernbauer-Hölzl, Elisabeth; Rosebrock, Felix; Müller, Mathias; Decker, Thomas

2017-01-01

Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signal transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine phosphorylation by activated JAKs. Downstream of interferon (IFN) receptors, activated JAKs cause the formation of the transcription factors IFN-stimulated gene factor 3 (ISGF3), a heterotrimer of STAT1, STAT2 and interferon regulatory factor 9 (IRF9) subunits, and gamma interferon-activated factor (GAF), a STAT1 homodimer. In recent years, several deviations from this paradigm were reported. These include kinase-independent JAK functions as well as extra- and intranuclear activities of U-STATs without phosphotyrosines. Additionally, transcriptional control by STAT complexes resembling neither GAF nor ISGF3 contributes to transcriptome changes in IFN-treated cells. Our review summarizes the contribution of non-canonical JAK-STAT signaling to the innate antimicrobial immunity imparted by IFN. Moreover, we touch upon functions of IFN pathway proteins beyond the IFN response. These include metabolic functions of IRF9 as well as the regulation of natural killer cell activity by kinase-dead TYK2 and different phosphorylation isoforms of STAT1.

Using Canonical Forms for Isomorphism Reduction in Graph-based Model Checking

NARCIS (Netherlands)

Kant, Gijs

Graph isomorphism checking can be used in graph-based model checking to achieve symmetry reduction. Instead of one-to-one comparing the graph representations of states, canonical forms of state graphs can be computed. These canonical forms can be used to store and compare states. However, computing

Two-dimensional multifractal cross-correlation analysis

International Nuclear Information System (INIS)

Xi, Caiping; Zhang, Shuning; Xiong, Gang; Zhao, Huichang; Yang, Yonghong

2017-01-01

Highlights: • We study the mathematical models of 2D-MFXPF, 2D-MFXDFA and 2D-MFXDMA. • Present the definition of the two-dimensional N 2 -partitioned multiplicative cascading process. • Do the comparative analysis of 2D-MC by 2D-MFXPF, 2D-MFXDFA and 2D-MFXDMA. • Provide a reference on the choice and parameter settings of these methods in practice. - Abstract: There are a number of situations in which several signals are simultaneously recorded in complex systems, which exhibit long-term power-law cross-correlations. This paper presents two-dimensional multifractal cross-correlation analysis based on the partition function (2D-MFXPF), two-dimensional multifractal cross-correlation analysis based on the detrended fluctuation analysis (2D-MFXDFA) and two-dimensional multifractal cross-correlation analysis based on the detrended moving average analysis (2D-MFXDMA). We apply these methods to pairs of two-dimensional multiplicative cascades (2D-MC) to do a comparative study. Then, we apply the two-dimensional multifractal cross-correlation analysis based on the detrended fluctuation analysis (2D-MFXDFA) to real images and unveil intriguing multifractality in the cross correlations of the material structures. At last, we give the main conclusions and provide a valuable reference on how to choose the multifractal algorithms in the potential applications in the field of SAR image classification and detection.

Conformal constraint in canonical quantum gravity

NARCIS (Netherlands)

t Hooft, G.

2010-01-01

Perturbative canonical quantum gravity is considered, when coupled to a renormalizable model for matter fields. It is proposed that the functional integral over the dilaton field should be disentangled from the other integrations over the metric fields. This should generate a conformally invariant

抗灰斑病大豆品种农艺性状、品质性状与产量性状的典型相关分析%Canonical Correlation Analysis for Agronomic Trait Group, Quality Trait Group and Yield in Soybean Immune to Grey Speck Disease

Institute of Scientific and Technical Information of China (English)

于凤瑶; 辛秀珺; 张代军; 周顺启

2012-01-01

To study the relationship between agronomic trait groups yield and quality trait groups of grey speck immune soybean, Canonical correlation analysis in 17 soybean cultivars and the establishment of a comprehensive selection index for yield are reported in this paper. The result showed that: the most important factors for seed yield are yield group's seed per plant, 3-seed pod, pods per plant; agronomic trait group's growth period, knot per plant and plant height, agronomic character and yield group are positively correlated. Growth days and 100-seed weight are positively correlated, bottom pod height and 4-seed pod are negatively correlated; canonical correlation coefficient between agronomic character and quality group has reached the significant level; growth days and protein content are positively correlated, middle height plant, moderate grow period, more knots per plant, low pod position, middle seed, more seed per plant in yield character should be chose as breeding goal, protein content can be improved by selection of grow days and 100-seed weight character.%为了探究抗灰斑病大豆品种农艺性状、产量性状、品质性状间的相互关系,选用了近年黑龙江省审定的17个抗灰斑病的大豆品种为试验材料,对其各性状及性状组基因型值进行相关与典型相关分析,并建立了以产量性状为目标的各性状选择指数.结果表明:对单株产量影响最大的是产量性状组的单株粒数、3粒荚数、单株荚数；农艺性状组的生育期、单株节数及株高,农艺性状与产量性状组间以正相关为主；生育日数与百粒重呈正相关、底荚高与4粒荚数呈负相关；品质性状与农艺性状组间典型相关系数达显著水平；且生育日数与蛋白质含量呈正相关,产量性状的选择应以株高中等、生育期适中、单株多有效节数、较低的结荚部位、粒中等大、单株粒数多为选育目标,蛋白质含量的提高可通过生育日数及百粒重等性状间接达到.

Normalization as a canonical neural computation

Science.gov (United States)

Carandini, Matteo; Heeger, David J.

2012-01-01

There is increasing evidence that the brain relies on a set of canonical neural computations, repeating them across brain regions and modalities to apply similar operations to different problems. A promising candidate for such a computation is normalization, in which the responses of neurons are divided by a common factor that typically includes the summed activity of a pool of neurons. Normalization was developed to explain responses in the primary visual cortex and is now thought to operate throughout the visual system, and in many other sensory modalities and brain regions. Normalization may underlie operations such as the representation of odours, the modulatory effects of visual attention, the encoding of value and the integration of multisensory information. Its presence in such a diversity of neural systems in multiple species, from invertebrates to mammals, suggests that it serves as a canonical neural computation. PMID:22108672

An evaluation of canonical forms for non-rigid 3D shape retrieval

OpenAIRE

Pickup, David; Liu, Juncheng; Sun, Xianfang; Rosin, Paul L.; Martin, Ralph R.; Cheng, Zhiquan; Lian, Zhouhui; Nie, Sipin; Jin, Longcun; Shamai, Gil; Sahillioğlu, Yusuf; Kavan, Ladislav

2018-01-01

Canonical forms attempt to factor out a non-rigid shape’s pose, giving a pose-neutral shape. This opens up the\\ud possibility of using methods originally designed for rigid shape retrieval for the task of non-rigid shape retrieval.\\ud We extend our recent benchmark for testing canonical form algorithms. Our new benchmark is used to evaluate a\\ud greater number of state-of-the-art canonical forms, on five recent non-rigid retrieval datasets, within two different\\ud retrieval frameworks. A tota...

Canonical quantum theory of gravitational field with higher derivatives, 3

International Nuclear Information System (INIS)

Kawasaki, Shoichiro; Kimura, Tadahiko

1983-01-01

A formulation which is invariant under an additional BRS transformation with nilpotency of order two is presented for the canonical theory of the renormalizable quantum gravity with higher derivatives. The canonical quantization is carried out and various equal time (anti-) commutation relations are derived. The asymptotic fields are reanalyzed. The physical particle contents are just the same as those obtained in previous papers. (author)

Canonical algorithms for numerical integration of charged particle motion equations

Science.gov (United States)

Efimov, I. N.; Morozov, E. A.; Morozova, A. R.

2017-02-01

A technique for numerically integrating the equation of charged particle motion in a magnetic field is considered. It is based on the canonical transformations of the phase space in Hamiltonian mechanics. The canonical transformations make the integration process stable against counting error accumulation. The integration algorithms contain a minimum possible amount of arithmetics and can be used to design accelerators and devices of electron and ion optics.

Canonical Entropy and Phase Transition of Rotating Black Hole

International Nuclear Information System (INIS)

Ren, Zhao; Yue-Qin, Wu; Li-Chun, Zhang

2008-01-01

Recently, the Hawking radiation of a black hole has been studied using the tunnel effect method. The radiation spectrum of a black hole is derived. By discussing the correction to spectrum of the rotating black hole, we obtain the canonical entropy. The derived canonical entropy is equal to the sum of Bekenstein–Hawking entropy and correction term. The correction term near the critical point is different from the one near others. This difference plays an important role in studying the phase transition of the black hole. The black hole thermal capacity diverges at the critical point. However, the canonical entropy is not a complex number at this point. Thus we think that the phase transition created by this critical point is the second order phase transition. The discussed black hole is a five-dimensional Kerr-AdS black hole. We provide a basis for discussing thermodynamic properties of a higher-dimensional rotating black hole. (general)

QCD phase transition at real chemical potential with canonical approach

Energy Technology Data Exchange (ETDEWEB)

Nakamura, Atsushi [RCNP, Osaka University,Osaka, 567-0047 (Japan); Nishina Center, RIKEN,Wako, Saitama 351-0198 (Japan); School of Biomedicine, Far Eastern Federal University,Vladivostok, 690950 (Russian Federation); Oka, Shotaro [Institute of Theoretical Physics, Department of Physics, Rikkyo University,Toshima-ku, Tokyo 171-8501 (Japan); Taniguchi, Yusuke [Graduate School of Pure and Applied Sciences, University of Tsukuba,Tsukuba, Ibaraki 305-8571 (Japan)

2016-02-08

We study the finite density phase transition in the lattice QCD at real chemical potential. We adopt a canonical approach and the canonical partition function is constructed for N{sub f}=2 QCD. After derivation of the canonical partition function we calculate observables like the pressure, the quark number density, its second cumulant and the chiral condensate as a function of the real chemical potential. We covered a wide range of temperature region starting from the confining low to the deconfining high temperature; 0.65T{sub c}≤T≤3.62T{sub c}. We observe a possible signal of the deconfinement and the chiral restoration phase transition at real chemical potential below T{sub c} starting from the confining phase. We give also the convergence range of the fugacity expansion.

A canonical theory of dynamic decision-making

Directory of Open Access Journals (Sweden)

John eFox

2013-04-01

Full Text Available Decision-making behaviour is studied in many very different fields, from medicine and economics to psychology and neuroscience, with major contributions from mathematics and statistics, computer science, AI and other technical disciplines. However the conceptualisation of what decision-making is and methods for studying it vary greatly and this has resulted in fragmentation of the field. A theory that can accommodate various perspectives may facilitate interdisciplinary working. We present such a theory in which decision-making is articulated as a set of canonical functions that are sufficiently general to accommodate diverse viewpoints, yet sufficiently precise that they can be instantiated in different ways for specific theoretical or practical purposes. The canons cover the whole decision cycle, from the framing of a decision based on the goals, beliefs, and background knowledge of the decision maker to the formulation of decision options, establishing preferences over them, and making commitments. Commitments can lead to the initiation of new decisions and any step in the cycle can incorporate reasoning about previous decisions and the rationales for them, and lead to revising or abandoning existing commitments. The theory situates decision making with respect to other high-level cognitive capabilities like problem-solving, planning and collaborative decision-making. The canonical approach is assessed in three domains: cognitive and neuro-psychology, artificial intelligence, and decision engineering.

A Canonical Theory of Dynamic Decision-Making

Science.gov (United States)

Fox, John; Cooper, Richard P.; Glasspool, David W.

2012-01-01

Decision-making behavior is studied in many very different fields, from medicine and economics to psychology and neuroscience, with major contributions from mathematics and statistics, computer science, AI, and other technical disciplines. However the conceptualization of what decision-making is and methods for studying it vary greatly and this has resulted in fragmentation of the field. A theory that can accommodate various perspectives may facilitate interdisciplinary working. We present such a theory in which decision-making is articulated as a set of canonical functions that are sufficiently general to accommodate diverse viewpoints, yet sufficiently precise that they can be instantiated in different ways for specific theoretical or practical purposes. The canons cover the whole decision cycle, from the framing of a decision based on the goals, beliefs, and background knowledge of the decision-maker to the formulation of decision options, establishing preferences over them, and making commitments. Commitments can lead to the initiation of new decisions and any step in the cycle can incorporate reasoning about previous decisions and the rationales for them, and lead to revising or abandoning existing commitments. The theory situates decision-making with respect to other high-level cognitive capabilities like problem solving, planning, and collaborative decision-making. The canonical approach is assessed in three domains: cognitive and neuropsychology, artificial intelligence, and decision engineering. PMID:23565100

The influence of canon law on ius commune in its formative period

Directory of Open Access Journals (Sweden)

Mehmeti Sami

2015-12-01

Full Text Available In the Medieval period, Roman law and canon law formed ius commune or the common European law. The similarity between Roman and canon law was that they used the same methods and the difference was that they relied on different authoritative texts. In their works canonists and civilists combined the ancient Greek achievements in philosophy with the Roman achievements in the field of law. Canonists were the first who carried out research on the distinctions between various legal sources and systematized them according to a hierarchical order. The Medieval civilists sought solutions in canon law for a large number of problems that Justinian’s Codification did not hinge on or did it only superficially. Solutions offered by canon law were accepted not only in the civil law of Continental Europe, but also in the English law.

Formulation of nonlinear chromaticity in circular accelerators by canonical perturbation method

International Nuclear Information System (INIS)

Takao, Masaru

2005-01-01

The formulation of nonlinear chromaticity in circular accelerators based on the canonical perturbation method is presented. Since the canonical perturbation method directly relates the tune shift to the perturbation Hamiltonian, it greatly simplifies the calculation of the nonlinear chromaticity. The obtained integral representation for nonlinear chromaticity can be systematically extended to higher orders

Fast numerical algorithm for the linear canonical transform.

Science.gov (United States)

Hennelly, Bryan M; Sheridan, John T

2005-05-01

The linear canonical transform (LCT) describes the effect of any quadratic phase system (QPS) on an input optical wave field. Special cases of the LCT include the fractional Fourier transform (FRT), the Fourier transform (FT), and the Fresnel transform (FST) describing free-space propagation. Currently there are numerous efficient algorithms used (for purposes of numerical simulation in the area of optical signal processing) to calculate the discrete FT, FRT, and FST. All of these algorithms are based on the use of the fast Fourier transform (FFT). In this paper we develop theory for the discrete linear canonical transform (DLCT), which is to the LCT what the discrete Fourier transform (DFT) is to the FT. We then derive the fast linear canonical transform (FLCT), an N log N algorithm for its numerical implementation by an approach similar to that used in deriving the FFT from the DFT. Our algorithm is significantly different from the FFT, is based purely on the properties of the LCT, and can be used for FFT, FRT, and FST calculations and, in the most general case, for the rapid calculation of the effect of any QPS.

Methods of Weyl representation of the phase space and canonical transformations. 1

International Nuclear Information System (INIS)

Budanov, V.G.

1984-01-01

The kernel structure of canonical transformation and differential equation for the intertwining operator is found. The Weyl symbol of operators producing linear canonical transformations is associated with the Cayley transformation of classical canonical transformation. Due to the invariance of the Weyl formalism a complete study of singularity and factorization of these symbols is manageable. In particular, one can study the symbols of Green functions and elements of Lie groups and find the spectra of arbitrary stationary quadratic Hamiltonians with the help of the known classification of the spectra of classical systems

A Nonlinear GMRES Optimization Algorithm for Canonical Tensor Decomposition

OpenAIRE

De Sterck, Hans

2011-01-01

A new algorithm is presented for computing a canonical rank-R tensor approximation that has minimal distance to a given tensor in the Frobenius norm, where the canonical rank-R tensor consists of the sum of R rank-one components. Each iteration of the method consists of three steps. In the first step, a tentative new iterate is generated by a stand-alone one-step process, for which we use alternating least squares (ALS). In the second step, an accelerated iterate is generated by a nonlinear g...

A Numerical-Analytical Approach Based on Canonical Transformations for Computing Optimal Low-Thrust Transfers

Science.gov (United States)

da Silva Fernandes, S.; das Chagas Carvalho, F.; Bateli Romão, J. V.

2018-04-01

A numerical-analytical procedure based on infinitesimal canonical transformations is developed for computing optimal time-fixed low-thrust limited power transfers (no rendezvous) between coplanar orbits with small eccentricities in an inverse-square force field. The optimization problem is formulated as a Mayer problem with a set of non-singular orbital elements as state variables. Second order terms in eccentricity are considered in the development of the maximum Hamiltonian describing the optimal trajectories. The two-point boundary value problem of going from an initial orbit to a final orbit is solved by means of a two-stage Newton-Raphson algorithm which uses an infinitesimal canonical transformation. Numerical results are presented for some transfers between circular orbits with moderate radius ratio, including a preliminary analysis of Earth-Mars and Earth-Venus missions.

Canonical trivialization of gravitational gradients

International Nuclear Information System (INIS)

Niedermaier, Max

2017-01-01

A one-parameter family of canonical transformations is constructed that reduces the Hamiltonian form of the Einstein–Hilbert action to its strong coupling limit where dynamical spatial gradients are absent. The parameter can alternatively be viewed as the overall scale of the spatial metric or as a fractional inverse power of Newton’s constant. The generating function of the canonical transformation is constructed iteratively as a powerseries in the parameter to all orders. The algorithm draws on Lie–Deprit transformation theory and defines a ‘trivialization map’ with several bonus properties: (i) Trivialization of the Hamiltonian constraint implies that of the action while the diffeomorphism constraint is automatically co-transformed. (ii) Only a set of ordinary differential equations needs to be solved to drive the iteration via a homological equation where no gauge fixing is required. (iii) In contrast to (the classical limit of) a Lagrangian trivialization map the algorithm also produces series solutions of the field equations. (iv) In the strong coupling theory temporal gauge variations are abelian, nevertheless the map intertwines with the respective gauge symmetries on the action, the field equations, and their solutions. (paper)

Canonical trivialization of gravitational gradients

Science.gov (United States)

Niedermaier, Max

2017-06-01

A one-parameter family of canonical transformations is constructed that reduces the Hamiltonian form of the Einstein-Hilbert action to its strong coupling limit where dynamical spatial gradients are absent. The parameter can alternatively be viewed as the overall scale of the spatial metric or as a fractional inverse power of Newton’s constant. The generating function of the canonical transformation is constructed iteratively as a powerseries in the parameter to all orders. The algorithm draws on Lie-Deprit transformation theory and defines a ‘trivialization map’ with several bonus properties: (i) Trivialization of the Hamiltonian constraint implies that of the action while the diffeomorphism constraint is automatically co-transformed. (ii) Only a set of ordinary differential equations needs to be solved to drive the iteration via a homological equation where no gauge fixing is required. (iii) In contrast to (the classical limit of) a Lagrangian trivialization map the algorithm also produces series solutions of the field equations. (iv) In the strong coupling theory temporal gauge variations are abelian, nevertheless the map intertwines with the respective gauge symmetries on the action, the field equations, and their solutions.

Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways

International Nuclear Information System (INIS)

Samarzija, Ivana; Sini, Patrizia; Schlange, Thomas; MacDonald, Gwen; Hynes, Nancy E.

2009-01-01

Untangling the signaling pathways involved in endothelial cell biology is of central interest for the development of antiangiogenesis based therapies. Here we report that Wnt3a induces the proliferation and migration of HUVECs, but does not affect their survival. Wnt3a-induced proliferation was VEGFR signaling independent, but reduced upon CamKII inhibition. In a search for the downstream mediators of Wnt3a's effects on HUVEC biology, we found that Wnt3a treatment leads to phosphorylation of DVL3 and stabilization of β-catenin. Moreover, under the same conditions we observed an upregulation in c-MYC, TIE-2 and GJA1 mRNA transcripts. Although treatment of HUVECs with Wnt5a induced DVL3 phosphorylation, we did not observe any of the other effects seen upon Wnt3a stimulation. Taken together, our data indicate that Wnt3a induces canonical and non-canonical Wnt signaling in HUVECs, and stimulates their proliferation and migration.

Extending canonical Monte Carlo methods

International Nuclear Information System (INIS)

Velazquez, L; Curilef, S

2010-01-01

In this paper, we discuss the implications of a recently obtained equilibrium fluctuation-dissipation relation for the extension of the available Monte Carlo methods on the basis of the consideration of the Gibbs canonical ensemble to account for the existence of an anomalous regime with negative heat capacities C α with α≈0.2 for the particular case of the 2D ten-state Potts model

The Canonical E2Fs Are Required for Germline Development in Arabidopsis

Directory of Open Access Journals (Sweden)

Xiaozhen Yao

2018-05-01

Full Text Available A number of cell fate determinations, including cell division, cell differentiation, and programmed cell death, intensely occur during plant germline development. How these cell fate determinations are regulated remains largely unclear. The transcription factor E2F is a core cell cycle regulator. Here we show that the Arabidopsis canonical E2Fs, including E2Fa, E2Fb, and E2Fc, play a redundant role in plant germline development. The e2fa e2fb e2fc (e2fabc triple mutant is sterile, although its vegetative development appears normal. On the one hand, the e2fabc microspores undergo cell death during pollen mitosis. Microspores start to die at the bicellular stage. By the tricellular stage, the majority of the e2fabc microspores are degenerated. On the other hand, a wild type ovule often has one megaspore mother cell (MMC, whereas the majority of e2fabc ovules have two to three MMCs. The subsequent female gametogenesis of e2fabc mutant is aborted and the vacuole is severely impaired in the embryo sac. Analysis of transmission efficiency showed that the canonical E2Fs from both male and female gametophyte are essential for plant gametogenesis. Our study reveals that the canonical E2Fs are required for plant germline development, especially the pollen mitosis and the archesporial cell (AC-MMC transition.

Canonical group quantization and boundary conditions

International Nuclear Information System (INIS)

Jung, Florian

2012-01-01

In the present thesis, we study quantization of classical systems with non-trivial phase spaces using the group-theoretical quantization technique proposed by Isham. Our main goal is a better understanding of global and topological aspects of quantum theory. In practice, the group-theoretical approach enables direct quantization of systems subject to constraints and boundary conditions in a natural and physically transparent manner -- cases for which the canonical quantization method of Dirac fails. First, we provide a clarification of the quantization formalism. In contrast to prior treatments, we introduce a sharp distinction between the two group structures that are involved and explain their physical meaning. The benefit is a consistent and conceptually much clearer construction of the Canonical Group. In particular, we shed light upon the 'pathological' case for which the Canonical Group must be defined via a central Lie algebra extension and emphasise the role of the central extension in general. In addition, we study direct quantization of a particle restricted to a half-line with 'hard wall' boundary condition. Despite the apparent simplicity of this example, we show that a naive quantization attempt based on the cotangent bundle over the half-line as classical phase space leads to an incomplete quantum theory; the reflection which is a characteristic aspect of the 'hard wall' is not reproduced. Instead, we propose a different phase space that realises the necessary boundary condition as a topological feature and demonstrate that quantization yields a suitable quantum theory for the half-line model. The insights gained in the present special case improve our understanding of the relation between classical and quantum theory and illustrate how contact interactions may be incorporated.

Towards a conceptual history of canonization in totalitarian societies

DEFF Research Database (Denmark)

Postoutenko, Kirill

2016-01-01

a reference to his slogans and speeches. The article compares such a canonization in Soviet Union with parallel processes in Nazi Germany (where Adolf Hitler and his texts are revered to a much lesser degree) and United States of America (where this development is missing altogether despite Franklin D....... Roosevelt unprecedented media exposure). It turns out that Stalin’s discursive canonization has multiple reasons including his reliance on rigid radial networks of power and communication (as opposed to rotation of political and social roles in democracies), his interactional detachment from listeners and...

Canonical representations of the Lie superalgebra osp(1,4)

International Nuclear Information System (INIS)

Blank, J.; Havlicek, M.; Lassner, W.; Bednar, M.

1981-06-01

The method for constructing infinite dimensional representations of Lie superalgebras proposed by the authors recently is applied to the superalgebra osp(1,4). Explicit formulae for its generators in terms of two or three pairs of operators fulfilling the canonical commutation relations, at most one pair of operators fulfilling the canonical anticommutation relations and at most one real parameter are obtained. The generators of the Lie subalgebra sp(4,IR) contains osp(1,4) are represented skew-symmetrically and both Casimir operators are equal to multiples of the unity operator. (author)

Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

Science.gov (United States)

Majoros, Andrea; Platanitis, Ekaterini; Kernbauer-Hölzl, Elisabeth; Rosebrock, Felix; Müller, Mathias; Decker, Thomas

2017-01-01

Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signal transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine phosphorylation by activated JAKs. Downstream of interferon (IFN) receptors, activated JAKs cause the formation of the transcription factors IFN-stimulated gene factor 3 (ISGF3), a heterotrimer of STAT1, STAT2 and interferon regulatory factor 9 (IRF9) subunits, and gamma interferon-activated factor (GAF), a STAT1 homodimer. In recent years, several deviations from this paradigm were reported. These include kinase-independent JAK functions as well as extra- and intranuclear activities of U-STATs without phosphotyrosines. Additionally, transcriptional control by STAT complexes resembling neither GAF nor ISGF3 contributes to transcriptome changes in IFN-treated cells. Our review summarizes the contribution of non-canonical JAK–STAT signaling to the innate antimicrobial immunity imparted by IFN. Moreover, we touch upon functions of IFN pathway proteins beyond the IFN response. These include metabolic functions of IRF9 as well as the regulation of natural killer cell activity by kinase-dead TYK2 and different phosphorylation isoforms of STAT1. PMID:28184222

Pair natural orbital and canonical coupled cluster reaction enthalpies involving light to heavy alkali and alkaline earth metals: the importance of sub-valence correlation

KAUST Repository

Minenkov, Yury; Bistoni, Giovanni; Riplinger, Christoph; Auer, Alexander A.; Neese, Frank; Cavallo, Luigi

2017-01-01

In this work, we tested canonical and domain based pair natural orbital coupled cluster methods (CCSD(T) and DLPNO-CCSD(T), respectively) for a set of 32 ligand exchange and association/dissociation reaction enthalpies involving ionic complexes

An unconventional canonical quantization of local scalar fields over quantum space-time

International Nuclear Information System (INIS)

Banai, M.

1985-12-01

An unconventional extension of the canonical quantization method is presented for a classical local field theory. The proposed canonical commutation relations have a solution in the A-valued Hilbert space where A is the algebra of the bounded operators of the Hilbert space Lsup(2) (IRsup(3)). The canonical equations as operator equations are equivalent formally with the classical field equations, and are well defined for interacting systems, too. This model of quantized field lacks some of the difficulties of the conventional approach. Examples satisfying the asymptotic condition provide examples for Haag-Kastler's axioms, however, they satisfy Wightman's axioms only partially. (author)

A COMPREHENSIVE ANALYSIS OF SWIFT/X-RAY TELESCOPE DATA. IV. SINGLE POWER-LAW DECAYING LIGHT CURVES VERSUS CANONICAL LIGHT CURVES AND IMPLICATIONS FOR A UNIFIED ORIGIN OF X-RAYS

International Nuclear Information System (INIS)

Liang Enwei; Lue Houjun; Hou Shujin; Zhang Binbin; Zhang Bing

2009-01-01

parent sample. Referenced to T 0 , the canonical XRT light curves well trace the SPL light curves. The T 0 's of the canonical light curves in our analysis are usually much larger than the offsets of the known precursors from the main GRBs. If the prior emission hypothesis is real, the X-ray emission is better interpreted within the external shock models based on the spectral and temporal indices of the X-rays. The lack of detection of a jet-like break in most XRT light curves implies that the opening angle of the prior emission jet would be usually large.

Mass effects in three-point chronological current correlators in n-dimensional multifermion models

International Nuclear Information System (INIS)

Kucheryavyj, V.I.

1991-01-01

Three-types of quantities associated with three-point chronological fermion-current correlators having arbitrary Lorentz and internal structure are calculated in the n-dimensional multifermion models with different masses. The analysis of vector and axial-vector Ward identities for regular (finite) and dimensionally regularized values of these quantities is carried out. Quantum corrections to the canonical Ward identities are obtained. These corrections are generally homogenious functions of zeroth order in masses and under some definite conditions they are reduced to known axial-vector anomalies. The structure and properties of quantum corrections to AVV and AAA correlators in the four-dimension space-time are investigated in detail

Linear response calculation using the canonical-basis TDHFB with a schematic pairing functional

International Nuclear Information System (INIS)

Ebata, Shuichiro; Nakatsukasa, Takashi; Yabana, Kazuhiro

2011-01-01

A canonical-basis formulation of the time-dependent Hartree-Fock-Bogoliubov (TDHFB) theory is obtained with an approximation that the pair potential is assumed to be diagonal in the time-dependent canonical basis. The canonical-basis formulation significantly reduces the computational cost. We apply the method to linear-response calculations for even-even nuclei. E1 strength distributions for proton-rich Mg isotopes are systematically calculated. The calculation suggests strong Landau damping of giant dipole resonance for drip-line nuclei.

The linear canonical transformation : definition and properties

NARCIS (Netherlands)

Bastiaans, Martin J.; Alieva, Tatiana; Healy, J.J.; Kutay, M.A.; Ozaktas, H.M.; Sheridan, J.T.

2016-01-01

In this chapter we introduce the class of linear canonical transformations, which includes as particular cases the Fourier transformation (and its generalization: the fractional Fourier transformation), the Fresnel transformation, and magnifier, rotation and shearing operations. The basic properties

Gender Differences in and the Relationships Between Social Anxiety and Problematic Internet Use: Canonical Analysis.

Science.gov (United States)

Baloğlu, Mustafa; Özteke Kozan, Hatice İrem; Kesici, Şahin

2018-01-24

The cognitive-behavioral model of problematic Internet use (PIU) proposes that psychological well-being is associated with specific thoughts and behaviors on the Internet. Hence, there is growing concern that PIU is associated with psychological impairments. Given the proposal of gender schema theory and social role theory, men and women are predisposed to experience social anxiety and engage in Internet use differently. Thus, an investigation of gender differences in these areas is warranted. According to the cognitive-behavioral model of PIU, social anxiety is associated with specific cognitions and behaviors on the Internet. Thus, an investigation of the association between social anxiety and PIU is essential. In addition, research that takes into account the multidimensional nature of social anxiety and PIU is lacking. Therefore, this study aimed to explore multivariate gender differences in and the relationships between social anxiety and PIU. Participants included 505 college students, of whom 241 (47.7%) were women and 264 (52.3%) were men. Participants' ages ranged from 18 to 22 years, with a mean age of 20.34 (SD=1.16). The Social Anxiety Scale and Problematic Internet Use Scale were used in data collection. Multivariate analysis of variance (MANOVA) and canonical correlation analysis were used. Mean differences between men and women were not statistically significant in social anxiety (λ=.02, F3,501=2.47, P=.06). In all three PIU dimensions, men scored higher than women, and MANOVA shows that multivariate difference was statistically significant (λ=.94, F3,501=10.69, Psocial anxiety levels between men and women. We found that men showed more difficulties than women in terms of running away from personal problems (ie, social benefit), used the Internet more excessively, and experienced more interpersonal problems with significant others due to Internet use. We conclude that men are under a greater risk of social impairments due to PIU. Our overall

Pulmonary alveolar proteinosis: Quantitative CT and pulmonary functional correlations

Energy Technology Data Exchange (ETDEWEB)

Guan, Yubao, E-mail: yubaoguan@163.com [Department of Radiology, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120 (China); State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China); Zeng, Qingsi [Department of Radiology, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120 (China); Yang, Haihong; Zheng, Jinping; Li, Shiyue; Gao, Yi [State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China); Deng, Yu [Department of Radiology, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120 (China); Mei, Jiang [State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China); He, Jianxing, E-mail: jianxing63@163.com [State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China); Zhong, Nanshan, E-mail: nanshan@vip.163.com [State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China)

2012-09-15

Objective: We assessed the relationship between quantitative computer tomography (qCT) and the pulmonary function test (PFT) or blood gas analysis in pulmonary alveolar proteinosis (PAP) patients, as well as the utility of these analyses to monitor responses to whole lung lavage (WLL) therapy. Methods: Thirty-eight PAP patients simultaneously received a CT scan and PFT. Fifteen of these patients, undergoing sequential WLL for a total of 20 lavages, also underwent chest CT scans and blood gas analysis before and after WLL, and 14 of 15 patients underwent simultaneous PFT analysis. Differences between the qCT and PFT results were analyzed by canonical correlation. Results: PAP patients with low predicted values for FVC, FEV1, D{sub LCO} and D{sub LCO}/VA indicated small airspace volume and mean lung inflation, low airspace volume/total lung volume ratio and high mean lung density. Correlation and regression analysis revealed a strong correlation between D{sub LCO} and PaO{sub 2} values with CT results. The qCT results indicated that WLL significantly decreased lung weights and mean lung densities, and improved the total airspace volume/total lung volume ratios and mean lung inflations. Conclusion: Quantitative CT may be a sensitive tool for measuring the response of PAP patients to medical interventions such as WLL.

Canonical Primal-Dual Method for Solving Non-convex Minimization Problems

OpenAIRE

Wu, Changzhi; Li, Chaojie; Gao, David Yang

2012-01-01

A new primal-dual algorithm is presented for solving a class of non-convex minimization problems. This algorithm is based on canonical duality theory such that the original non-convex minimization problem is first reformulated as a convex-concave saddle point optimization problem, which is then solved by a quadratically perturbed primal-dual method. %It is proved that the popular SDP method is indeed a special case of the canonical duality theory. Numerical examples are illustrated. Comparing...

Canonical quantization of so-called non-Lagrangian systems

Energy Technology Data Exchange (ETDEWEB)

Gitman, D.M. [Universidade de Sao Paulo, Instituto de Fisica, Caixa Postal 66318-CEP, Sao Paulo, S.P. (Brazil); Kupriyanov, V.G. [Universidade de Sao Paulo, Instituto de Fisica, Caixa Postal 66318-CEP, Sao Paulo, S.P. (Brazil); Tomsk State University, Physics Department, Tomsk (Russian Federation)

2007-04-15

We present an approach to the canonical quantization of systems with equations of motion that are historically called non-Lagrangian equations. Our viewpoint of this problem is the following: despite the fact that a set of differential equations cannot be directly identified with a set of Euler-Lagrange equations, one can reformulate such a set in an equivalent first-order form that can always be treated as the Euler-Lagrange equations of a certain action. We construct such an action explicitly. It turns out that in the general case the hamiltonization and canonical quantization of such an action are non-trivial problems, since the theory involves time-dependent constraints. We adopt the general approach of hamiltonization and canonical quantization for such theories as described in D.M. Gitman, I.V. Tyutin, Quantization of Fields with Constraints (Springer, Berlin, 1990). to the case under consideration. There exists an ambiguity (that cannot be reduced to the addition of a total time derivative) in associating a Lagrange function with a given set of equations. We present a complete description of this ambiguity. The proposed scheme is applied to the quantization of a general quadratic theory. In addition, we consider the quantization of a damped oscillator and of a radiating point-like charge. (orig.)

Canonical quantization of so-called non-Lagrangian systems

International Nuclear Information System (INIS)

Gitman, D.M.; Kupriyanov, V.G.

2007-01-01

We present an approach to the canonical quantization of systems with equations of motion that are historically called non-Lagrangian equations. Our viewpoint of this problem is the following: despite the fact that a set of differential equations cannot be directly identified with a set of Euler-Lagrange equations, one can reformulate such a set in an equivalent first-order form that can always be treated as the Euler-Lagrange equations of a certain action. We construct such an action explicitly. It turns out that in the general case the hamiltonization and canonical quantization of such an action are non-trivial problems, since the theory involves time-dependent constraints. We adopt the general approach of hamiltonization and canonical quantization for such theories as described in D.M. Gitman, I.V. Tyutin, Quantization of Fields with Constraints (Springer, Berlin, 1990). to the case under consideration. There exists an ambiguity (that cannot be reduced to the addition of a total time derivative) in associating a Lagrange function with a given set of equations. We present a complete description of this ambiguity. The proposed scheme is applied to the quantization of a general quadratic theory. In addition, we consider the quantization of a damped oscillator and of a radiating point-like charge. (orig.)

Fibrin-Enhanced Canonical Wnt Signaling Directs Plasminogen Expression in Cementoblasts

Directory of Open Access Journals (Sweden)

Saeed Ur Rahman

2017-11-01

Full Text Available Cementum is a mineralized layer on the tooth’s root surface and facilitates the biomechanical anchoring of fibrous connective tissues as a part of tooth-supportive complexes. Previously, we observed that OCCM30 cementoblasts cultured on fibrin matrices underwent apoptosis due to fibrin degradation through the expression of proteases. Here, we demonstrated that OCCM30 on fibrin matrices (OCCM30-fibrin enhanced canonical Wnt signaling, which directed to plasminogen expression. The OCCM30-fibrin showed higher levels of Wnt3a expression, nuclear translocation of β-catenin, and T-cell factor (TCF optimal motif (TOP reporter activity than the cells on tissue culture dishes (OCCM30-TCD, indicating that the OCCM30-fibrin enhanced canonical Wnt/β-catenin signaling. Also, OCCM30-fibrin expressed biomineralization-associated markers at higher levels than OCCM30-TCD, of which levels were further increased with LiCl, a Wnt signaling activator. The OCCM30 cementoblasts simultaneously showed that high levels of plasminogen, a critical component of fibrinolysis, were expressed in the OCCM30-fibrin. Activation of canonical Wnt signaling with LiCl treatment or with forced lymphoid enhancer factor 1 (LEF1-expression increased the expression of plasminogen. On the contrary, the inhibition of canonical Wnt signaling with siRNAs against Wnt3a or β-catenin abrogated fibrin-enhanced plasminogen expression. Furthermore, there are three conserved putative response elements for the LEF1/β-catenin complex in the plasminogen proximal promoter regions (−900 to +54. Site-directed mutations and chromatin immunoprecipitation indicated that canonical Wnt signaling directed plasminogen expression. Taken together, this study suggests that fibrin-based materials can modulate functional periodontal formations in controlling cementoblast differentiation and fibrin degradation.

Canonical Wnt signaling induces a primitive endoderm metastable state in mouse embryonic stem cells.

Science.gov (United States)

Price, Feodor D; Yin, Hang; Jones, Andrew; van Ijcken, Wilfred; Grosveld, Frank; Rudnicki, Michael A

2013-04-01

Activation of the canonical Wnt signaling pathway synergizes with leukemia inhibitory factor (LIF) to maintain pluripotency of mouse embryonic stem cells (mESCs). However, in the absence of LIF, Wnt signaling is unable to maintain ESCs in the undifferentiated state. To investigate the role of canonical Wnt signaling in pluripotency and lineage specification, we expressed Wnt3a in mESCs and characterized them in growth and differentiation. We found that activated canonical Wnt signaling induced the formation of a reversible metastable primitive endoderm state in mESC. Upon subsequent differentiation, Wnt3a-stimulated mESCs gave rise to large quantities of visceral endoderm. Furthermore, we determined that the ability of canonical Wnt signaling to induce a metastable primitive endoderm state was mediated by Tbx3. Our data demonstrates a specific role for canonical Wnt signaling in promoting pluripotency while at the same time priming cells for subsequent differentiation into the primitive endoderm lineage. Copyright © 2013 AlphaMed Press.

Algorithmic transformation of multi-loop master integrals to a canonical basis with CANONICA

Science.gov (United States)

Meyer, Christoph

2018-01-01

The integration of differential equations of Feynman integrals can be greatly facilitated by using a canonical basis. This paper presents the Mathematica package CANONICA, which implements a recently developed algorithm to automatize the transformation to a canonical basis. This represents the first publicly available implementation suitable for differential equations depending on multiple scales. In addition to the presentation of the package, this paper extends the description of some aspects of the algorithm, including a proof of the uniqueness of canonical forms up to constant transformations.

Simultaneous Semi-Coupled Dictionary Learning for Matching in Canonical Space.

Science.gov (United States)

Das, Nilotpal; Mandal, Devraj; Biswas, Soma

2017-05-24

Cross-modal recognition and matching with privileged information are important challenging problems in the field of computer vision. The cross-modal scenario deals with matching across different modalities and needs to take care of the large variations present across and within each modality. The privileged information scenario deals with the situation that all the information available during training may not be available during the testing stage and hence algorithms need to leverage the extra information from the training stage itself. We show that for multi-modal data, either one of the above situations may arise if one modality is absent during testing. Here, we propose a novel framework which can handle both these scenarios seamlessly with applications to matching multi-modal data. The proposed approach jointly uses data from the two modalities to build a canonical representation which encompasses information from both the modalities. We explore four different types of canonical representations for different types of data. The algorithm computes dictionaries and canonical representation for data from both the modalities such that the transformed sparse coefficients of both the modalities are equal to that of the canonical representation. The sparse coefficients are finally matched using Mahalanobis metric. Extensive experiments on different datasets, involving RGBD, text-image and audio-image data show the effectiveness of the proposed framework.

Canonical group quantization and boundary conditions

Energy Technology Data Exchange (ETDEWEB)

Jung, Florian

2012-07-16

In the present thesis, we study quantization of classical systems with non-trivial phase spaces using the group-theoretical quantization technique proposed by Isham. Our main goal is a better understanding of global and topological aspects of quantum theory. In practice, the group-theoretical approach enables direct quantization of systems subject to constraints and boundary conditions in a natural and physically transparent manner -- cases for which the canonical quantization method of Dirac fails. First, we provide a clarification of the quantization formalism. In contrast to prior treatments, we introduce a sharp distinction between the two group structures that are involved and explain their physical meaning. The benefit is a consistent and conceptually much clearer construction of the Canonical Group. In particular, we shed light upon the 'pathological' case for which the Canonical Group must be defined via a central Lie algebra extension and emphasise the role of the central extension in general. In addition, we study direct quantization of a particle restricted to a half-line with 'hard wall' boundary condition. Despite the apparent simplicity of this example, we show that a naive quantization attempt based on the cotangent bundle over the half-line as classical phase space leads to an incomplete quantum theory; the reflection which is a characteristic aspect of the 'hard wall' is not reproduced. Instead, we propose a different phase space that realises the necessary boundary condition as a topological feature and demonstrate that quantization yields a suitable quantum theory for the half-line model. The insights gained in the present special case improve our understanding of the relation between classical and quantum theory and illustrate how contact interactions may be incorporated.

Hamiltonian formalism, quantization and S matrix for supergravity. [S matrix, canonical constraints

Energy Technology Data Exchange (ETDEWEB)

Fradkin, E S; Vasiliev, M A [AN SSSR, Moscow. Fizicheskij Inst.

1977-12-05

The canonical formalism for supergravity is constructed. The algebra of canonical constraints is found. The correct expression for the S matrix is obtained. Usual 'covariant methods' lead to an incorrect S matrix in supergravity since a new four-particle interaction of ghostfields survives in the Lagrangian expression of the S matrix.

A new methodology of spatial cross-correlation analysis.

Science.gov (United States)

Chen, Yanguang

2015-01-01

Spatial correlation modeling comprises both spatial autocorrelation and spatial cross-correlation processes. The spatial autocorrelation theory has been well-developed. It is necessary to advance the method of spatial cross-correlation analysis to supplement the autocorrelation analysis. This paper presents a set of models and analytical procedures for spatial cross-correlation analysis. By analogy with Moran's index newly expressed in a spatial quadratic form, a theoretical framework is derived for geographical cross-correlation modeling. First, two sets of spatial cross-correlation coefficients are defined, including a global spatial cross-correlation coefficient and local spatial cross-correlation coefficients. Second, a pair of scatterplots of spatial cross-correlation is proposed, and the plots can be used to visually reveal the causality behind spatial systems. Based on the global cross-correlation coefficient, Pearson's correlation coefficient can be decomposed into two parts: direct correlation (partial correlation) and indirect correlation (spatial cross-correlation). As an example, the methodology is applied to the relationships between China's urbanization and economic development to illustrate how to model spatial cross-correlation phenomena. This study is an introduction to developing the theory of spatial cross-correlation, and future geographical spatial analysis might benefit from these models and indexes.

An efficient algorithm for calculation of the Luenberger canonical form.

Science.gov (United States)

Jordan, D.; Sridhar, B.

1973-01-01

A new algorithm is presented to obtain the Luenberger canonical form for multivariable systems. A distinct feature of the method is that the canonical form is obtained directly and, if necessary, the similarity transformation can be computed. There is a substantial reduction in the amount of computation compared to Luenberger's method. The reduced computations along with Gaussian techniques lend greater inherent accuracy and the ability to refine the solution with additional computations. An example is presented to illustrate the technique.

Orthogonal transformations for change detection, Matlab code

DEFF Research Database (Denmark)

2005-01-01

Matlab code to do multivariate alteration detection (MAD) analysis, maximum autocorrelation factor (MAF) analysis, canonical correlation analysis (CCA) and principal component analysis (PCA) on image data.......Matlab code to do multivariate alteration detection (MAD) analysis, maximum autocorrelation factor (MAF) analysis, canonical correlation analysis (CCA) and principal component analysis (PCA) on image data....

Time as a Quantum Observable, Canonically Conjugated to Energy, and Foundations of Self-Consistent Time Analysis of Quantum Processes

Directory of Open Access Journals (Sweden)

V. S. Olkhovsky

2009-01-01

Full Text Available Recent developments are reviewed and some new results are presented in the study of time in quantum mechanics and quantum electrodynamics as an observable, canonically conjugate to energy. This paper deals with the maximal Hermitian (but nonself-adjoint operator for time which appears in nonrelativistic quantum mechanics and in quantum electrodynamics for systems with continuous energy spectra and also, briefly, with the four-momentum and four-position operators, for relativistic spin-zero particles. Two measures of averaging over time and connection between them are analyzed. The results of the study of time as a quantum observable in the cases of the discrete energy spectra are also presented, and in this case the quasi-self-adjoint time operator appears. Then, the general foundations of time analysis of quantum processes (collisions and decays are developed on the base of time operator with the proper measures of averaging over time. Finally, some applications of time analysis of quantum processes (concretely, tunneling phenomena and nuclear processes are reviewed.

Stabilizing canonical-ensemble calculations in the auxiliary-field Monte Carlo method

Science.gov (United States)

Gilbreth, C. N.; Alhassid, Y.

2015-03-01

Quantum Monte Carlo methods are powerful techniques for studying strongly interacting Fermi systems. However, implementing these methods on computers with finite-precision arithmetic requires careful attention to numerical stability. In the auxiliary-field Monte Carlo (AFMC) method, low-temperature or large-model-space calculations require numerically stabilized matrix multiplication. When adapting methods used in the grand-canonical ensemble to the canonical ensemble of fixed particle number, the numerical stabilization increases the number of required floating-point operations for computing observables by a factor of the size of the single-particle model space, and thus can greatly limit the systems that can be studied. We describe an improved method for stabilizing canonical-ensemble calculations in AFMC that exhibits better scaling, and present numerical tests that demonstrate the accuracy and improved performance of the method.

Horizon-preserving dualities and perturbations in non-canonical scalar field cosmologies

International Nuclear Information System (INIS)

Geshnizjani, Ghazal; Kinney, William H.; Dizgah, Azadeh Moradinezhad

2012-01-01

We generalize the cosmological duality between inflation and cyclic contraction under the interchange a↔H to the case of non-canonical scalar field theories with varying speed of sound. The single duality in the canonical case generalizes to a family of three dualities constructed to leave the cosmological acoustic horizon invariant. We find three classes of models: (I) DBI inflation, (II) the non-canonical generalization of cyclic contraction, and (III) a new cosmological solution with rapidly decreasing speed of sound and relatively slowly growing scale factor, which we dub stalled cosmology. We construct dual analogs to the inflationary slow roll approximation, and solve for the curvature perturbation in all three cases. Both cyclic contraction and stalled cosmology predict a strongly blue spectrum for the curvature perturbations inconsistent with observations

Correspondence and canonicity in non-classical logic

NARCIS (Netherlands)

Sourabh, S.

2015-01-01

In this thesis we study correspondence and canonicity for non-classical logic using algebraic and order-topological methods. Correspondence theory is aimed at answering the question of how precisely modal, first-order, second-order languages interact and overlap in their shared semantic environment.

Probing the small distance structure of canonical

NARCIS (Netherlands)

t Hooft, G.

2010-01-01

In canonical quantum gravity, the formal functional integral includes an integration over the local conformal factor, and we propose to perform the functional integral over this factor before doing any of the other functional integrals. By construction, the resulting effective theory would be

Canonical sampling of a lattice gas

International Nuclear Information System (INIS)

Mueller, W.F.

1997-01-01

It is shown that a sampling algorithm, recently proposed in conjunction with a lattice-gas model of nuclear fragmentation, samples the canonical ensemble only in an approximate fashion. A residual weight factor has to be taken into account to calculate correct thermodynamic averages. Then, however, the algorithm is numerically inefficient. copyright 1997 The American Physical Society

Universal canonical entropy for gravitating systems

Indian Academy of Sciences (India)

Similar to this is the case of ref. [12] which also uses the saddle point approximation to express the microcanonical entropy in terms of the canonical entropy [12a]. Recalling that there is at least 'circumstantial' evidence that the microcanonical entropy has a 'universal' form [13–15], identical to that obtained in ref. [6] quoted.

Canonical momenta and numerical instabilities in particle codes

International Nuclear Information System (INIS)

Godfrey, B.B.

1975-01-01

A set of warm plasma dispersion relations appropriate to a large class of electromagnetic plasma simulation codes is derived. The numerical Cherenkov instability is shown by analytic and numerical analysis of these dispersion relations to be the most significant nonphysical effect involving transverse electromagnetic waves. The instability arises due to a spurious phase shift between resonant particles and light waves, caused by a basic incompatibility between the Lagrangian treatment of particle positions and the Eulerian treatment of particle velocities characteristic of most PIC--CIC algorithms. It is demonstrated that, through the use of canonical momentum, this mismatch is alleviated sufficiently to completely eliminate the Cherenkov instability. Collateral effects on simulation accuracy and on other numerical instabilities appear to be minor

Reproducibility of disc and macula optical coherence tomography using the Canon OCT-HS100 as compared with the Zeiss Cirrus HD-OCT.

Science.gov (United States)

Brautaset, Rune; Birkeldh, Ulrika; Rosén, Rebecka; Ramsay, Marika Wahlberg; Nilsson, Maria

2014-01-01

In a clinical setting, the usefulness of optical coherence tomography (OCT) is strongly dependent on reproducibility of the measurement. The aim of the present study was to evaluate macula and optic disc measurement reproducibility with the new spectral-domain OCT (SD-OCT) from Canon (Canon OCT-HS100) and to compare reproducibility and obtained measurements with the Zeiss Cirrus HD-OCT. Macula and optic disc parameters from the right eyes of 31 subjects were obtained twice with both instruments. Interoperator reproducibility was evaluated by use of the coefficient of repeatability (CR), and the obtained measurements were compared between the instruments. No difference in interoperator reproducibility could be found when comparing the 2 instruments and reproducibility ranged from 3.94% to 12.77% for optic disc parameters and from 1.19% to 3.54% for macula parameters. The lowest reproducibility was found for cup volume and vertical cup/disc ratio with both instruments. For all macula and retinal nerve fiber layer (RNFL) thickness measurements, there was a statistical difference when comparing the 2 instruments, except for RFNL measurements of the superior quadrant, with the Canon OCT-HS100 always evaluating the thickness to be thicker; however, the 2 instruments correlated well. The Canon OCT-HS100 is a reproducible instrument that matches the Zeiss Cirrus HD-OCT well. It remains to be evaluated how sensitive the Canon OCT-HS100 is to detect small subtle changes in optic disc parameters and macular nerve fiber layer thickness. Furthermore, due to the differences in thickness estimation, it is important to emphasize that SD-OCTs are not interchangeable.

A New Methodology of Spatial Cross-Correlation Analysis

Science.gov (United States)

Chen, Yanguang

2015-01-01

Spatial correlation modeling comprises both spatial autocorrelation and spatial cross-correlation processes. The spatial autocorrelation theory has been well-developed. It is necessary to advance the method of spatial cross-correlation analysis to supplement the autocorrelation analysis. This paper presents a set of models and analytical procedures for spatial cross-correlation analysis. By analogy with Moran’s index newly expressed in a spatial quadratic form, a theoretical framework is derived for geographical cross-correlation modeling. First, two sets of spatial cross-correlation coefficients are defined, including a global spatial cross-correlation coefficient and local spatial cross-correlation coefficients. Second, a pair of scatterplots of spatial cross-correlation is proposed, and the plots can be used to visually reveal the causality behind spatial systems. Based on the global cross-correlation coefficient, Pearson’s correlation coefficient can be decomposed into two parts: direct correlation (partial correlation) and indirect correlation (spatial cross-correlation). As an example, the methodology is applied to the relationships between China’s urbanization and economic development to illustrate how to model spatial cross-correlation phenomena. This study is an introduction to developing the theory of spatial cross-correlation, and future geographical spatial analysis might benefit from these models and indexes. PMID:25993120

Schwinger–Keldysh canonical formalism for electronic Raman scattering

Energy Technology Data Exchange (ETDEWEB)

Su, Yuehua, E-mail: suyh@ytu.edu.cn

2016-03-01

Inelastic low-energy Raman and high-energy X-ray scatterings have made great progress in instrumentation to investigate the strong electronic correlations in matter. However, theoretical study of the relevant scattering spectrum is still a challenge. In this paper, we present a Schwinger–Keldysh canonical perturbation formalism for the electronic Raman scattering, where all the resonant, non-resonant and mixed responses are considered uniformly. We show how to use this formalism to evaluate the cross section of the electronic Raman scattering off an one-band superconductor. All the two-photon scattering processes from electrons, the non-resonant charge density response, the elastic Rayleigh scattering, the fluorescence, the intrinsic energy-shift Raman scattering and the mixed response, are included. In the mean-field superconducting state, Cooper pairs contribute only to the non-resonant response. All the other responses are dominated by the single-particle excitations and are strongly suppressed due to the opening of the superconducting gap. Our formalism for the electronic Raman scattering can be easily extended to study the high-energy resonant inelastic X-ray scattering.

Unifying Dark Matter and Dark Energy with non-Canonical Scalars

OpenAIRE

Mishra, Swagat S.; Sahni, Varun

2018-01-01

Non-canonical scalar fields with the Lagrangian ${\\cal L} = X^\\alpha - V(\\phi)$, possess the attractive property that the speed of sound, $c_s^{2} = (2\\,\\alpha - 1)^{-1}$, can be exceedingly small for large values of $\\alpha$. This allows a non-canonical field to cluster and behave like warm/cold dark matter on small scales. We demonstrate that simple potentials such as $V = V_0\\coth^2{\\phi}$ and the Starobinsky-type potential $V(\\phi) = V_0 \\left ( 1 - e^{-{\\phi}}\\right )^{2}$ can unify dark...

IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.

Science.gov (United States)

Zhao, Huan-Yu; Han, Yang; Wang, Jian; Yang, Lian-He; Zheng, Xiao-Ying; Du, Jiang; Wu, Guang-Ping; Wang, En-Hua

2017-06-01

IQ-domain GTPase-activating protein 1 is a scaffolding protein with multidomain which plays a role in modulating dishevelled (Dvl) nuclear translocation in canonical Wnt pathway. However, the biological function and mechanism of IQ-domain GTPase-activating protein 1 in invasive ductal carcinoma (IDC) remain unknown. In this study, we found that IQ-domain GTPase-activating protein 1 expression was elevated in invasive ductal carcinoma, which was positively correlated with tumor grade, lymphatic metastasis, and poor prognosis. Coexpression of IQ-domain GTPase-activating protein 1 and Dvl in the nucleus and cytoplasm of invasive ductal carcinoma was significantly correlated but not in the membrane. Postoperative survival in the patients with their coexpression in the nucleus and cytoplasm was obviously lower than that without coexpression. The positive expression rates of c-myc and cyclin D1 were significantly higher in the patients with nuclear coexpression of Dvl and IQ-domain GTPase-activating protein 1 than that with cytoplasmic coexpression, correlating with poor prognosis. IQ-domain GTPase-activating protein 1 significantly enhanced cell proliferation and invasion in invasive ductal carcinoma cell lines by interacting with Dvl in cytoplasm to promote Dvl nuclear translocation so as to upregulate the expression of c-myc and cyclin D1. Collectively, our data suggest that IQ-domain GTPase-activating protein 1 may promote the malignant phenotype of invasive ductal carcinoma via canonical Wnt signaling, and it could be used as a potential prognostic biomarker for breast cancer patients.

On the canonical treatment of Lagrangian constraints

International Nuclear Information System (INIS)

Barbashov, B.M.

2001-01-01

The canonical treatment of dynamic systems with manifest Lagrangian constraints proposed by Berezin is applied to concrete examples: a special Lagrangian linear in velocities, relativistic particles in proper time gauge, a relativistic string in orthonormal gauge, and the Maxwell field in the Lorentz gauge

On the canonical treatment of Lagrangian constraints

International Nuclear Information System (INIS)

Barbashov, B.M.

2001-01-01

The canonical treatment of dynamic systems with manifest Lagrangian constraints proposed by Berezin is applied to concrete examples: a specific Lagrangian linear in velocities, relativistic particles in proper time gauge, a relativistic string in orthonormal gauge, and the Maxwell field in the Lorentz gauge

A Requirement for ZAK Kinase Activity in Canonical TGF-β Signaling

Directory of Open Access Journals (Sweden)

Shyam Nyati

2016-12-01

Full Text Available The sterile alpha motif and leucine zipper containing kinase ZAK (AZK, MLT, MLK7, is a MAPK-kinase kinase (MKKK. Like most MAPKKKs which are known to activate the c-Jun. amino-terminal kinase (JNK pathway, ZAK has been shown to participate in the transduction of Transforming growth factor-β (TGF-β-mediated non-canonical signaling. A role for ZAK in SMAD-dependent, canonical TGF-β signaling has not been previously appreciated. Using a combination of functional genomics and biochemical techniques, we demonstrate that ZAK regulates canonical TGFβRI/II signaling in lung and breast cancer cell lines and may serve as a key node in the regulation of TGFBR kinase activity. Remarkably, we demonstrate that siRNA mediated depletion of ZAK strongly inhibited TGF-β dependent SMAD2/3 activation and subsequent promoter activation (SMAD binding element driven luciferase expression; SBE4-Luc. A ZAK specific inhibitor (DHP-2, dose-dependently activated the bioluminescent TGFBR-kinase activity reporter (BTR, blocked TGF-β induced SMAD2/3 phosphorylation and SBE4-Luc activation and cancer cell-invasion. In aggregate, these findings identify a novel role for the ZAK kinase in canonical TGF-β signaling and an invasive cancer cell phenotype thus providing a novel target for TGF-β inhibition.

Correlated wave and particle observations upstream of the earth's bow shock

International Nuclear Information System (INIS)

Harvey, C.C.; Bavassano-Cattaneo, M.B.; Dobrowolny, M.; Orsini, S.; Mangeney, A.; Russell, C.T.

1981-01-01

Data from three ISEE experiments has been analyzed during several periods of turbulence observed in the solar wind upstream of the earth's quasi-parallel bow shock. Radio observations are used to validate a shock model, which is subsequently used to compute various geometrical parameters during all the periods studied. One typical 9-hour period on November 4, 1977, is discussed in some detail to illustrate the parameters studied and the correlations found. It is shown that during this period, the radio noise spectrum has two components, one centered around the local electron plasma frequency and the other at somewhat lower frequencies; the latter component has a shorter wavelength and correlates with the level of MHD turbulence. A multivariate canonical statistical analysis of particle and MHD data during a 2-week period shows that the proton anisotropy and turbulence level correlate well with the minimum backstreaming proton parallel velocity p/sub min/ which, as defined here, is a purely geometrical parameter. Trivariate analysis shows that the correlation of particles and turbulence with the angle between the magnetic field and the shock normal have their sense reversed when allowance is made for the strong correlations with p/sub min/. A very good correlation has been found between power and compressibility in magnetic fluctuations

Intermittency analysis of correlated data

International Nuclear Information System (INIS)

Wosiek, B.

1992-01-01

We describe the method of the analysis of the dependence of the factorial moments on the bin size in which the correlations between the moments computed for different bin sizes are taken into account. For large multiplicity nucleus-nucleus data inclusion of the correlations does not change the values of the slope parameter, but gives errors significantly reduced as compared to the case of fits with no correlations. (author)

Are Young Children's Drawings Canonically Biased?

Science.gov (United States)

Picard, Delphine; Durand, Karine

2005-01-01

In a between-subjects design, 4-to 6-year-olds were asked to draw from three-dimensional (3D) models, two-and-a-half-dimensional (212D) models with or without depth cues, or two-dimensional (2D) models of a familiar object (a saucepan) in noncanonical orientations (handle at the back or at the front). Results showed that canonical errors were…

Canonical ward identities in generalized QCD

International Nuclear Information System (INIS)

Li Ziping

1995-01-01

The canonical Ward identities for a system with singular higher-order Lagrangian are derived and some application to the generalized QCD are given. The new relations of the Ward identities for gauge ghost field proper vertices are obtained which differ from the usual Ward-Takahashi identities arising from BRS invariance. The expressions for PCAC and generalized PCAC of AVV vertices are also obtained

An Analysis of Historical Vignettes by Ibn Sina in the Canon of Medicine on the Structure and Function of the Cardiorespiratory Apparatus.

Science.gov (United States)

Mazengenya, Pedzisai; Bhikha, Rashid

2017-06-01

Ibn Sina is regarded as one of the greatest physicians, thinkers and medical scholars in the history of medicine. Ibn Sina, a Persian scholar in the medieval era, wrote a famous book of medicine, the Canon of Medicine. The book was adopted as the main textbook of medicine in most Western and Persian universities. In the present critique, we analyzed the functional and anatomic descriptions of the heart, airways and the lungs as viewed by Ibn Sina in volume three of the Canon of Medicine textbook, and compared them to modern anatomy texts.

Comments on the charge-monopole canonical formalism

International Nuclear Information System (INIS)

Comay, C.

1988-01-01

A recently published canonical formalism of a charge-monopole system written by means of Clifford algebras is discussed. It is shown that the introduction of the Lorentz force must be accompanied by the removal of the pseudo-scalar terms from the lagrangian. Several conclusions follow. (orig.)

Canonical extensions of the Johnson homomorphisms to the Torelli groupoid

DEFF Research Database (Denmark)

Bene, Alex; Kawazumi, Nariya; Penner, Robert

2009-01-01

We prove that every trivalent marked bordered fatgraph comes equipped with a canonical generalized Magnus expansion in the sense of Kawazumi. This Magnus expansion is used to give canonical extensions of the higher Johnson homomorphisms τm , for m 1 , to the Torelli groupoid, and we provide...... a recursive combinatorial formula for tensor representatives of these extensions. In particular, we give an explicit 1-cocycle in the dual fatgraph complex which extends τ2 and thus answer affirmatively a question of Morita and Penner. To illustrate our techniques for calculating higher Johnson homomorphisms...

Discourse context and the recognition of reduced and canonical spoken words

OpenAIRE

Brouwer, S.; Mitterer, H.; Huettig, F.

2013-01-01

In two eye-tracking experiments we examined whether wider discourse information helps the recognition of reduced pronunciations (e.g., 'puter') more than the recognition of canonical pronunciations of spoken words (e.g., 'computer'). Dutch participants listened to sentences from a casual speech corpus containing canonical and reduced target words. Target word recognition was assessed by measuring eye fixation proportions to four printed words on a visual display: the target, a "reduced form" ...

A Top-Down Account of Linear Canonical Transforms

Directory of Open Access Journals (Sweden)

Kurt Bernardo Wolf

2012-06-01

Full Text Available We contend that what are called Linear Canonical Transforms (LCTs should be seen as a part of the theory of unitary irreducible representations of the '2+1' Lorentz group. The integral kernel representation found by Collins, Moshinsky and Quesne, and the radial and hyperbolic LCTs introduced thereafter, belong to the discrete and continuous representation series of the Lorentz group in its parabolic subgroup reduction. The reduction by the elliptic and hyperbolic subgroups can also be considered to yield LCTs that act on functions, discrete or continuous in other Hilbert spaces. We gather the summation and integration kernels reported by Basu and Wolf when studiying all discrete, continuous, and mixed representations of the linear group of 2×2 real matrices. We add some comments on why all should be considered canonical.

An algorithm to compute the canonical basis of an irreducible Uq(g)-module

OpenAIRE

de Graaf, W. A.

2002-01-01

An algorithm is described to compute the canonical basis of an irreducible module over a quantized enveloping algebra of a finite-dimensional semisimple Lie algebra. The algorithm works for modules that are constructed as a submodule of a tensor product of modules with known canonical bases.

Electrostatic Screening and Charge Correlation Effects in Micellization of Ionic Surfactants

KAUST Repository

Jusufi, Arben; Hynninen, Antti-Pekka; Haataja, Mikko; Panagiotopoulos, Athanassios Z.

2009-01-01

We have used atomistic simulations to study the role of electrostatic screening and charge correlation effects in self-assembly processes of ionic surfactants into micelles. Specifically, we employed grand canonical Monte Carlo simulations

Canonical and D-transformations in Theories with Constraints

OpenAIRE

Gitman, Dmitri M.

1995-01-01

A class class of transformations in a super phase space (we call them D-transformations) is described, which play in theories with second-class constraints the role of ordinary canonical transformations in theories without constraints.

Van der Vyver’s analysis of rights: a case study drawn from thirteenth-century canon law

Directory of Open Access Journals (Sweden)

Charles J. Reid, Jr.

1999-03-01

Full Text Available In an important article published in 1988, Johan Van der Vyver challenged the prevailing reliance on Wesley Hohfeld’s taxonomy of rights. Hohfeld's division of rights into claims, powers, privileges and immunities, Van der Vyver stresses, is excessively concerned with "inter-individual legal relations” at the expense of the right-holder's relationship to the object of the right. Van der Vyver proposes instead that an assertion of right involves three distinct juridic aspects:• legal capacity, which is "the competence to occupy the offices of legal subject;• legal claim, which "comprises claims of a legal subject as against other persons to a legal object";• legal entitlement, which specifies the boundaries of the right-holder's ability to use, enjoy, consume, destroy or alienate the right in question.This article applies Van der Vyver’s taxonomy to the operations of thirteenthcentury canon law, and demonstrates that Van der Vyver’s analysis provides greater depth than Hohfeld's, in that it considers both the relationship of the person claiming a particular right and the object of that right.

Application of the TRAC-PD2 code to the simulation of the CANON experiment

International Nuclear Information System (INIS)

Neves Conti, T. das; Freitas, R.L.

1985-01-01

A comparison between the TRAC -PD2 code calculations and results from the CANON experiment is presented. The CANON experiment simulates the loss of coolant accident through the depressurization of a horizontal tube containing water at different temperatures. The experiment consist of the instantaneous rupture at one end of the tubing and the corresponding pressure and void fraction measurements during the transient. The comparison shows that the TRAC-PD2 code predicts satisfactorily the pressure and void fraction evolution in the CANON experiment. (F.C.) [pt

Traditional Herbal Remedies for Burn Wound Healing in Canon of Avicenna

OpenAIRE

Aliasl, Jale; Khoshzaban, Fariba

2013-01-01

Burns are a worldwide problem. The incidence of severe burns has been higher than the combined incidence of tuberculosis and HIV infections. Throughout history there have been many different treatments prescribed for burns. The Canon is the masterpiece of Avicenna’s medical books. The Canon includes a description of 785 simple drugs. Avicenna believed in burn treatment, which follows two goals. The first goal is prevention of blistering and the second goal is treatment of the burn wound after...

The Canon is el Boom, et. al., or the Hispanic Difference

OpenAIRE

Bell-Villada, Gene H.

2002-01-01

In his article, Gene H. Bell-Villada's "The Canon is el Boom, et. al., or the Hispanic Difference," argues that the rich, globally acclaimed, foundational yet contestatory prose literature produced in Latin America allows teachers and scholars of Spanish to teach what is essentially the "canon" via work that is still fresh, yet historically provocative. Bell-Villada argues that in a time of reconsidering the importance of literature in literature programs, programs of Spanish language and cul...

Transforming differential equations of multi-loop Feynman integrals into canonical form

Energy Technology Data Exchange (ETDEWEB)

Meyer, Christoph [Institut für Physik, Humboldt-Universität zu Berlin,12489 Berlin (Germany)

2017-04-03

The method of differential equations has been proven to be a powerful tool for the computation of multi-loop Feynman integrals appearing in quantum field theory. It has been observed that in many instances a canonical basis can be chosen, which drastically simplifies the solution of the differential equation. In this paper, an algorithm is presented that computes the transformation to a canonical basis, starting from some basis that is, for instance, obtained by the usual integration-by-parts reduction techniques. The algorithm requires the existence of a rational transformation to a canonical basis, but is otherwise completely agnostic about the differential equation. In particular, it is applicable to problems involving multiple scales and allows for a rational dependence on the dimensional regulator. It is demonstrated that the algorithm is suitable for current multi-loop calculations by presenting its successful application to a number of non-trivial examples.

Transforming differential equations of multi-loop Feynman integrals into canonical form

Science.gov (United States)

Meyer, Christoph

2017-04-01

The method of differential equations has been proven to be a powerful tool for the computation of multi-loop Feynman integrals appearing in quantum field theory. It has been observed that in many instances a canonical basis can be chosen, which drastically simplifies the solution of the differential equation. In this paper, an algorithm is presented that computes the transformation to a canonical basis, starting from some basis that is, for instance, obtained by the usual integration-by-parts reduction techniques. The algorithm requires the existence of a rational transformation to a canonical basis, but is otherwise completely agnostic about the differential equation. In particular, it is applicable to problems involving multiple scales and allows for a rational dependence on the dimensional regulator. It is demonstrated that the algorithm is suitable for current multi-loop calculations by presenting its successful application to a number of non-trivial examples.

Transforming differential equations of multi-loop Feynman integrals into canonical form

International Nuclear Information System (INIS)

Meyer, Christoph

2017-01-01

The method of differential equations has been proven to be a powerful tool for the computation of multi-loop Feynman integrals appearing in quantum field theory. It has been observed that in many instances a canonical basis can be chosen, which drastically simplifies the solution of the differential equation. In this paper, an algorithm is presented that computes the transformation to a canonical basis, starting from some basis that is, for instance, obtained by the usual integration-by-parts reduction techniques. The algorithm requires the existence of a rational transformation to a canonical basis, but is otherwise completely agnostic about the differential equation. In particular, it is applicable to problems involving multiple scales and allows for a rational dependence on the dimensional regulator. It is demonstrated that the algorithm is suitable for current multi-loop calculations by presenting its successful application to a number of non-trivial examples.

Islamic Canon law encounters South African financing and banking ...

African Journals Online (AJOL)

Islamic Canon law encounters South African financing and banking institutions: Prospects and possibilities for Islamic economic empowerment and Black Economic Empowerment in a Democratic South Africa.

Signature and Pathophysiology of Non-canonical Pores in Voltage-Dependent Cation Channels.

Science.gov (United States)

Held, Katharina; Voets, Thomas; Vriens, Joris

2016-01-01

Opening and closing of voltage-gated cation channels allows the regulated flow of cations such as Na(+), K(+), and Ca(2+) across cell membranes, which steers essential physiological processes including shaping of action potentials and triggering Ca(2+)-dependent processes. Classical textbooks describe the voltage-gated cation channels as membrane proteins with a single, central aqueous pore. In recent years, however, evidence has accumulated for the existence of additional ion permeation pathways in this group of cation channels, distinct from the central pore, which here we collectively name non-canonical pores. Whereas the first non-canonical pores were unveiled only after making specific point mutations in the voltage-sensor region of voltage-gated Na(+) and K(+) channels, recent evidence indicates that they may also be functional in non-mutated channels. Moreover, several channelopathies have been linked to mutations that cause the appearance of a non-canonical ion permeation pathway as a new pathological mechanism. This review provides an integrated overview of the biophysical properties of non-canonical pores described in voltage-dependent cation channels (KV, NaV, Cav, Hv1, and TRPM3) and of the (patho)physiological impact of opening of such pores.

Canonical sound speed profile and related ray acoustic parameters in the Bay of Bengal

Digital Repository Service at National Institute of Oceanography (India)

Murty, T.V.R.; Sadhuram, Y.; Rao, M.M.M.; Rao, B.P.; SuryaPrakash, S.; Chandramouli, P.; Murthy, K.S.R.; Prasad, K.V.S.R.

Following Munk's canonical theory, canonical parameters (i.e., B the stratification scale and epsilon the perturbation coefficient) in adiabatic ocean are obtained using SOFAR channel parameters (i.e., C sound velocity at the channel axis, Z sub(1...

A review of the evidence for the canonical Wnt pathway in autism spectrum disorders

Directory of Open Access Journals (Sweden)

Kalkman Hans

2012-10-01

Full Text Available Abstract Microdeletion and microduplication copy number variations are found in patients with autism spectrum disorder and in a number of cases they include genes that are involved in the canonical Wnt signaling pathway (for example, FZD9, BCL9 or CDH8. Association studies investigating WNT2, DISC1, MET, DOCK4 or AHI1 also provide evidence that the canonical Wnt pathway might be affected in autism. Prenatal medication with sodium-valproate or antidepressant drugs increases autism risk. In animal studies, it has been found that these medications promote Wnt signaling, including among others an increase in Wnt2 gene expression. Notably, the available genetic information indicates that not only canonical Wnt pathway activation, but also inhibition seems to increase autism risk. The canonical Wnt pathway plays a role in dendrite growth and suboptimal activity negatively affects the dendritic arbor. In principle, this provides a logical explanation as to why both hypo- and hyperactivity may generate a similar set of behavioral and cognitive symptoms. However, without a validated biomarker to stratify for deviant canonical Wnt pathway activity, it is probably too dangerous to treat patients with compounds that modify pathway activity.

Baryon number violation and novel canonical anti-commutation relations

Science.gov (United States)

Fujikawa, Kazuo; Tureanu, Anca

2018-02-01

The possible neutron-antineutron oscillation is described by an effective quadratic Lagrangian analogous to the BCS theory. It is shown that the conventional equal-time anti-commutation relations of the neutron variable n (t , x →) are modified by the baryon number violating terms. This is established by the Bjorken-Johnson-Low prescription and also by the canonical quantization combined with equations of motion. This novel canonical behavior can give rise to an important physical effect, which is illustrated by analyzing the Lagrangian that violates the baryon number but gives rise to the degenerate effective Majorana fermions and thus no neutron-antineutron oscillation. Technically, this model is neatly treated using a relativistic analogue of the Bogoliubov transformation.

Climate Prediction Center - monthly Outlook

Science.gov (United States)

Weather Service NWS logo - Click to go to the NWS home page Climate Prediction Center Site Map News Outlooks monthly Climate Outlooks Banner OFFICIAL Forecasts June 2018 [UPDATED MONTHLY FORECASTS SERVICE ) Canonical Correlation Analysis ECCA - Ensemble Canonical Correlation Analysis Optimal Climate Normals

A third-generation density-functional-theory-based method for calculating canonical molecular orbitals of large molecules.

Science.gov (United States)

Hirano, Toshiyuki; Sato, Fumitoshi

2014-07-28

We used grid-free modified Cholesky decomposition (CD) to develop a density-functional-theory (DFT)-based method for calculating the canonical molecular orbitals (CMOs) of large molecules. Our method can be used to calculate standard CMOs, analytically compute exchange-correlation terms, and maximise the capacity of next-generation supercomputers. Cholesky vectors were first analytically downscaled using low-rank pivoted CD and CD with adaptive metric (CDAM). The obtained Cholesky vectors were distributed and stored on each computer node in a parallel computer, and the Coulomb, Fock exchange, and pure exchange-correlation terms were calculated by multiplying the Cholesky vectors without evaluating molecular integrals in self-consistent field iterations. Our method enables DFT and massively distributed memory parallel computers to be used in order to very efficiently calculate the CMOs of large molecules.

Canonical decomposition of magnetotelluric responses: Experiment on 1D anisotropic structures

Science.gov (United States)

Guo, Ze-qiu; Wei, Wen-bo; Ye, Gao-feng; Jin, Sheng; Jing, Jian-en

2015-08-01

Horizontal electrical heterogeneity of subsurface earth is mostly originated from structural complexity and electrical anisotropy, and local near-surface electrical heterogeneity will severely distort regional electromagnetic responses. Conventional distortion analyses for magnetotelluric soundings are primarily physical decomposition methods with respect to isotropic models, which mostly presume that the geoelectric distribution of geological structures is of local and regional patterns represented by 3D/2D models. Due to the widespread anisotropy of earth media, the confusion between 1D anisotropic responses and 2D isotropic responses, and the defects of physical decomposition methods, we propose to conduct modeling experiments with canonical decomposition in terms of 1D layered anisotropic models, and the method is one of the mathematical decomposition methods based on eigenstate analyses differentiated from distortion analyses, which can be used to recover electrical information such as strike directions, and maximum and minimum conductivity. We tested this method with numerical simulation experiments on several 1D synthetic models, which turned out that canonical decomposition is quite effective to reveal geological anisotropic information. Finally, for the background of anisotropy from previous study by geological and seismological methods, canonical decomposition is applied to real data acquired in North China Craton for 1D anisotropy analyses, and the result shows that, with effective modeling and cautious interpretation, canonical decomposition could be another good method to detect anisotropy of geological media.

Accurate orbital-dependent correlation and exchange-correlation potentials from non-iterative ab initio dft calculations

Science.gov (United States)

Grabowski, Ireneusz; Lotrich, Victor

2005-08-01

A new approximate non-iterative procedure to obtain accurate correlation and exchange-correlation potentials of Kohn-Sham (KS) density functional theory (DFT) is presented. By carrying out only one step of the correlated optimized effective potential (OEP) iterations following the standard iterative exchange-only OEP, one can recover accurate correlation potentials corresponding to the orbital-dependent second-order many-body perturbation theory [MBPT(2)] energy functional that are hardly discernible from those obtained by the more expensive, fully iterative procedure. This new 'one-step' OEP-MBPT(2) algorithm reflects the non-iterative, perturbative algorithm of standard, canonical MBPT(2) of ab initio wave function theory, while it allows the correlation potentials to readjust and include the majority of the MBPT(2) correlation effect. It is also flexible in the treatment of exchange and the Hartree-Fock orbitals may be used in lieu of the exchange-only OEP orbitals, when the correlation or exchange-correlation potential is of interest.

The analysis of decimation and interpolation in the linear canonical transform domain.

Science.gov (United States)

Xu, Shuiqing; Chai, Yi; Hu, Youqiang; Huang, Lei; Feng, Li

2016-01-01

Decimation and interpolation are the two basic building blocks in the multirate digital signal processing systems. As the linear canonical transform (LCT) has been shown to be a powerful tool for optics and signal processing, it is worthwhile and interesting to analyze the decimation and interpolation in the LCT domain. In this paper, the definition of equivalent filter in the LCT domain have been given at first. Then, by applying the definition, the direct implementation structure and polyphase networks for decimator and interpolator in the LCT domain have been proposed. Finally, the perfect reconstruction expressions for differential filters in the LCT domain have been presented as an application. The proposed theorems in this study are the bases for generalizations of the multirate signal processing in the LCT domain, which can advance the filter banks theorems in the LCT domain.

Correlated Hopping in the 1D Falicov--Kimball Model

Science.gov (United States)

Gajek, Z.; Lemanski, R.

2001-10-01

Ground state phase diagrams in the canonical ensemble of the one-dimensional Falicov-Kimball Model (FKM) with the correlated hopping are presented for several values of the model parameters. As compare to the conventional FKM, the diagrams exhibit a loss of the particle--hole symmetry.

The roles of theory in canonical action research

NARCIS (Netherlands)

Davison, R.M.; Martinsons, M.G.; Ou, C.X.J.

2012-01-01

Canonical action research (CAR) aims to address real-world problems and improve organizational performance by combining scholarly observations with practical interventions. However, efforts to conduct CAR have revealed challenges that reflect a significant research–practice gap. We examine these

MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors.

Directory of Open Access Journals (Sweden)

Brigitte Teissedre

Full Text Available Canonical Wnt/beta-catenin signaling regulates stem/progenitor cells and, when perturbed, induces many human cancers. A significant proportion of human breast cancer is associated with loss of secreted Wnt antagonists and mice expressing MMTV-Wnt1 and MMTV-DeltaN89beta-catenin develop mammary adenocarcinomas. Many studies have assumed these mouse models of breast cancer to be equivalent. Here we show that MMTV-Wnt1 and MMTV-DeltaN89beta-catenin transgenes induce tumors with different phenotypes. Using axin2/conductin reporter genes we show that MMTV-Wnt1 and MMTV-DeltaN89beta-catenin activate canonical Wnt signaling within distinct cell-types. DeltaN89beta-catenin activated signaling within a luminal subpopulation scattered along ducts that exhibited a K18(+ER(-PR(-CD24(highCD49f(low profile and progenitor properties. In contrast, MMTV-Wnt1 induced canonical signaling in K14(+ basal cells with CD24/CD49f profiles characteristic of two distinct stem/progenitor cell-types. MMTV-Wnt1 produced additional profound effects on multiple cell-types that correlated with focal activation of the Hedgehog pathway. We document that large melanocytic nevi are a hitherto unreported hallmark of early hyperplastic Wnt1 glands. These nevi formed along the primary mammary ducts and were associated with Hedgehog pathway activity within a subset of melanocytes and surrounding stroma. Hh pathway activity also occurred within tumor-associated stromal and K14(+/p63(+ subpopulations in a manner correlated with Wnt1 tumor onset. These data show MMTV-Wnt1 and MMTV-DeltaN89beta-catenin induce canonical signaling in distinct progenitors and that Hedgehog pathway activation is linked to melanocytic nevi and mammary tumor onset arising from excess Wnt1 ligand. They further suggest that Hedgehog pathway activation maybe a critical component and useful indicator of breast tumors arising from unopposed Wnt1 ligand.

Canonical transformations and exact invariants for dissipative systems

International Nuclear Information System (INIS)

Pedrosa, I.A.

1986-01-01

A simple treatment to the problem of finding exact invariants and related auxiliary equations for time-dependent oscillators with friction is presented. The treatment is based on the use of a time-dependent canonical transformation and an auxiliary transformation. (Author) [pt

Correlated Hopping in the 1d Falicov-Kimball Model

International Nuclear Information System (INIS)

Gajek, Z.; Lemanski, R.

2001-01-01

Ground state phase diagrams in the canonical ensemble of the one-dimensional Falicov-Kimball Model FKM) with the correlated hopping are presented for several values of the model parameters. As compare to the conventional FKM, the diagrams exhibit a loss of the particle-hole symmetry. (author)

Influence Function and Robust Variant of Kernel Canonical Correlation Analysis

OpenAIRE

Alam, Md. Ashad; Fukumizu, Kenji; Wang, Yu-Ping

2017-01-01

Many unsupervised kernel methods rely on the estimation of the kernel covariance operator (kernel CO) or kernel cross-covariance operator (kernel CCO). Both kernel CO and kernel CCO are sensitive to contaminated data, even when bounded positive definite kernels are used. To the best of our knowledge, there are few well-founded robust kernel methods for statistical unsupervised learning. In addition, while the influence function (IF) of an estimator can characterize its robustness, asymptotic ...

Magnetic phase diagrams from non-collinear canonical band theory

DEFF Research Database (Denmark)

Shallcross, Sam; Nordstrom, L.; Sharma, S.

2007-01-01

A canonical band theory of non-collinear magnetism is developed and applied to the close packed fcc and bcc crystal structures. This is a parameter-free theory where the crystal and magnetic symmetry and exchange splitting uniquely determine the electronic bands. In this way, we are able...... hybridization, and on this basis we are able to analyze the microscopic reasons behind the occurrence of non-collinear magnetism in the elemental itinerant magnets....... to construct phase diagrams of magnetic order for the fcc and bcc lattices. Several examples of non-collinear magnetism are seen to be canonical in origin, in particular, that of gamma-Fe. In this approach, the determination of magnetic stability results solely from changes in kinetic energy due to spin...

Canonical Drude Weight for Non-integrable Quantum Spin Chains

Science.gov (United States)

Mastropietro, Vieri; Porta, Marcello

2018-03-01

The Drude weight is a central quantity for the transport properties of quantum spin chains. The canonical definition of Drude weight is directly related to Kubo formula of conductivity. However, the difficulty in the evaluation of such expression has led to several alternative formulations, accessible to different methods. In particular, the Euclidean, or imaginary-time, Drude weight can be studied via rigorous renormalization group. As a result, in the past years several universality results have been proven for such quantity at zero temperature; remarkably, the proofs work for both integrable and non-integrable quantum spin chains. Here we establish the equivalence of Euclidean and canonical Drude weights at zero temperature. Our proof is based on rigorous renormalization group methods, Ward identities, and complex analytic ideas.

CAPE suppresses migration and invasion of prostate cancer cells via activation of non-canonical Wnt signaling.

Science.gov (United States)

Tseng, Jen-Chih; Lin, Ching-Yu; Su, Liang-Chen; Fu, Hsiao-Hui; Yang, Shiaw-Der; Chuu, Chih-Pin

2016-06-21

Prostate cancer (PCa) was the fifth most common cancer overall in the world. More than 80% of patients died from PCa developed bone metastases. Caffeic acid phenethyl ester (CAPE) is a main bioactive component of honeybee hive propolis. Transwell and wound healing assays demonstrated that CAPE treatment suppressed the migration and invasion of PC-3 and DU-145 PCa cells. Gelatin zymography and Western blotting indicated that CAPE treatment reduced the abundance and activity of MMP-9 and MMP-2. Analysis using Micro-Western Array (MWA), a high-throughput antibody-based proteomics platform with 264 antibodies detecting signaling proteins involved in important pathways indicated that CAPE treatment induced receptor tyrosine kinase-like orphan receptor 2 (ROR2) in non-canonical Wnt signaling pathway but suppressed abundance of β-catenin, NF-κB activity, PI3K-Akt signaling, and epithelial-mesenchymal transition (EMT). Overexpression or knockdown of ROR2 suppressed or enhanced cell migration of PC-3 cells, respectively. TCF-LEF promoter binding assay revealed that CAPE treatment reduced canonical Wnt signaling. Intraperitoneal injection of CAPE reduced the metastasis of PC-3 xenografts in tail vein injection nude mice model. Immunohistochemical staining demonstrated that CAPE treatment increased abundance of ROR2 and Wnt5a but decreased protein expression of Ki67, Frizzle 4, NF-κB p65, MMP-9, Snail, β-catenin, and phosphorylation of IκBα. Clinical evidences suggested that genes affected by CAPE treatment (CTNNB1, RELA, FZD5, DVL3, MAPK9, SNAl1, ROR2, SMAD4, NFKBIA, DUSP6, and PLCB3) correlate with the aggressiveness of PCa. Our study suggested that CAPE may be a potential therapeutic agent for patients with advanced PCa.

Turbulent transport across invariant canonical flux surfaces

International Nuclear Information System (INIS)

Hollenberg, J.B.; Callen, J.D.

1994-07-01

Net transport due to a combination of Coulomb collisions and turbulence effects in a plasma is investigated using a fluid moment description that allows for kinetic and nonlinear effects via closure relations. The model considered allows for ''ideal'' turbulent fluctuations that distort but preserve the topology of species-dependent canonical flux surfaces ψ number-sign,s triple-bond ∫ dF · B number-sign,s triple-bond ∇ x [A + (m s /q s )u s ] in which u s is the flow velocity of the fluid species. Equations for the net transport relative to these surfaces due to ''nonideal'' dissipative processes are found for the total number of particles and total entropy enclosed by a moving canonical flux surface. The corresponding particle transport flux is calculated using a toroidal axisymmetry approximation of the ideal surfaces. The resulting Lagrangian transport flux includes classical, neoclassical-like, and anomalous contributions and shows for the first time how these various contributions should be summed to obtain the total particle transport flux

An optimization approach for fitting canonical tensor decompositions.

Energy Technology Data Exchange (ETDEWEB)

Dunlavy, Daniel M. (Sandia National Laboratories, Albuquerque, NM); Acar, Evrim; Kolda, Tamara Gibson

2009-02-01

Tensor decompositions are higher-order analogues of matrix decompositions and have proven to be powerful tools for data analysis. In particular, we are interested in the canonical tensor decomposition, otherwise known as the CANDECOMP/PARAFAC decomposition (CPD), which expresses a tensor as the sum of component rank-one tensors and is used in a multitude of applications such as chemometrics, signal processing, neuroscience, and web analysis. The task of computing the CPD, however, can be difficult. The typical approach is based on alternating least squares (ALS) optimization, which can be remarkably fast but is not very accurate. Previously, nonlinear least squares (NLS) methods have also been recommended; existing NLS methods are accurate but slow. In this paper, we propose the use of gradient-based optimization methods. We discuss the mathematical calculation of the derivatives and further show that they can be computed efficiently, at the same cost as one iteration of ALS. Computational experiments demonstrate that the gradient-based optimization methods are much more accurate than ALS and orders of magnitude faster than NLS.

Orthogonal transformations for change detection, Matlab code (ENVI-like headers)

DEFF Research Database (Denmark)

2007-01-01

Matlab code to do (iteratively reweighted) multivariate alteration detection (MAD) analysis, maximum autocorrelation factor (MAF) analysis, canonical correlation analysis (CCA) and principal component analysis (PCA) on image data; accommodates ENVI (like) header files.......Matlab code to do (iteratively reweighted) multivariate alteration detection (MAD) analysis, maximum autocorrelation factor (MAF) analysis, canonical correlation analysis (CCA) and principal component analysis (PCA) on image data; accommodates ENVI (like) header files....

Polynomial meta-models with canonical low-rank approximations: Numerical insights and comparison to sparse polynomial chaos expansions

International Nuclear Information System (INIS)

Konakli, Katerina; Sudret, Bruno

2016-01-01

The growing need for uncertainty analysis of complex computational models has led to an expanding use of meta-models across engineering and sciences. The efficiency of meta-modeling techniques relies on their ability to provide statistically-equivalent analytical representations based on relatively few evaluations of the original model. Polynomial chaos expansions (PCE) have proven a powerful tool for developing meta-models in a wide range of applications; the key idea thereof is to expand the model response onto a basis made of multivariate polynomials obtained as tensor products of appropriate univariate polynomials. The classical PCE approach nevertheless faces the “curse of dimensionality”, namely the exponential increase of the basis size with increasing input dimension. To address this limitation, the sparse PCE technique has been proposed, in which the expansion is carried out on only a few relevant basis terms that are automatically selected by a suitable algorithm. An alternative for developing meta-models with polynomial functions in high-dimensional problems is offered by the newly emerged low-rank approximations (LRA) approach. By exploiting the tensor–product structure of the multivariate basis, LRA can provide polynomial representations in highly compressed formats. Through extensive numerical investigations, we herein first shed light on issues relating to the construction of canonical LRA with a particular greedy algorithm involving a sequential updating of the polynomial coefficients along separate dimensions. Specifically, we examine the selection of optimal rank, stopping criteria in the updating of the polynomial coefficients and error estimation. In the sequel, we confront canonical LRA to sparse PCE in structural-mechanics and heat-conduction applications based on finite-element solutions. Canonical LRA exhibit smaller errors than sparse PCE in cases when the number of available model evaluations is small with respect to the input

Polynomial meta-models with canonical low-rank approximations: Numerical insights and comparison to sparse polynomial chaos expansions

Energy Technology Data Exchange (ETDEWEB)

Konakli, Katerina, E-mail: konakli@ibk.baug.ethz.ch; Sudret, Bruno

2016-09-15

The growing need for uncertainty analysis of complex computational models has led to an expanding use of meta-models across engineering and sciences. The efficiency of meta-modeling techniques relies on their ability to provide statistically-equivalent analytical representations based on relatively few evaluations of the original model. Polynomial chaos expansions (PCE) have proven a powerful tool for developing meta-models in a wide range of applications; the key idea thereof is to expand the model response onto a basis made of multivariate polynomials obtained as tensor products of appropriate univariate polynomials. The classical PCE approach nevertheless faces the “curse of dimensionality”, namely the exponential increase of the basis size with increasing input dimension. To address this limitation, the sparse PCE technique has been proposed, in which the expansion is carried out on only a few relevant basis terms that are automatically selected by a suitable algorithm. An alternative for developing meta-models with polynomial functions in high-dimensional problems is offered by the newly emerged low-rank approximations (LRA) approach. By exploiting the tensor–product structure of the multivariate basis, LRA can provide polynomial representations in highly compressed formats. Through extensive numerical investigations, we herein first shed light on issues relating to the construction of canonical LRA with a particular greedy algorithm involving a sequential updating of the polynomial coefficients along separate dimensions. Specifically, we examine the selection of optimal rank, stopping criteria in the updating of the polynomial coefficients and error estimation. In the sequel, we confront canonical LRA to sparse PCE in structural-mechanics and heat-conduction applications based on finite-element solutions. Canonical LRA exhibit smaller errors than sparse PCE in cases when the number of available model evaluations is small with respect to the input

A general transformation to canonical form for potentials in pairwise interatomic interactions.

Science.gov (United States)

Walton, Jay R; Rivera-Rivera, Luis A; Lucchese, Robert R; Bevan, John W

2015-06-14

A generalized formulation of explicit force-based transformations is introduced to investigate the concept of a canonical potential in both fundamental chemical and intermolecular bonding. Different classes of representative ground electronic state pairwise interatomic interactions are referenced to a chosen canonical potential illustrating application of such transformations. Specifically, accurately determined potentials of the diatomic molecules H2, H2(+), HF, LiH, argon dimer, and one-dimensional dissociative coordinates in Ar-HBr, OC-HF, and OC-Cl2 are investigated throughout their bound potentials. Advantages of the current formulation for accurately evaluating equilibrium dissociation energies and a fundamentally different unified perspective on nature of intermolecular interactions will be emphasized. In particular, this canonical approach has significance to previous assertions that there is no very fundamental distinction between van der Waals bonding and covalent bonding or for that matter hydrogen and halogen bonds.

Infants' Recognition of Objects Using Canonical Color

Science.gov (United States)

Kimura, Atsushi; Wada, Yuji; Yang, Jiale; Otsuka, Yumiko; Dan, Ippeita; Masuda, Tomohiro; Kanazawa, So; Yamaguchi, Masami K.

2010-01-01

We explored infants' ability to recognize the canonical colors of daily objects, including two color-specific objects (human face and fruit) and a non-color-specific object (flower), by using a preferential looking technique. A total of 58 infants between 5 and 8 months of age were tested with a stimulus composed of two color pictures of an object…

Denominator function for canonical SU(3) tensor operators

International Nuclear Information System (INIS)

Biedenharn, L.C.; Lohe, M.A.; Louck, J.D.

1985-01-01

The definition of a canonical unit SU(3) tensor operator is given in terms of its characteristic null space as determined by group-theoretic properties of the intertwining number. This definition is shown to imply the canonical splitting conditions used in earlier work for the explicit and unique (up to +- phases) construction of all SU(3) WCG coefficients (Wigner--Clebsch--Gordan). Using this construction, an explicit SU(3)-invariant denominator function characterizing completely the canonically defined WCG coefficients is obtained. It is shown that this denominator function (squared) is a product of linear factors which may be obtained explicitly from the characteristic null space times a ratio of polynomials. These polynomials, denoted G/sup t//sub q/, are defined over three (shift) parameters and three barycentric coordinates. The properties of these polynomials (hence, of the corresponding invariant denominator function) are developed in detail: These include a derivation of their degree, symmetries, and zeros. The symmetries are those induced on the shift parameters and barycentric coordinates by the transformations of a 3 x 3 array under row interchange, column interchange, and transposition (the group of 72 operations leaving a 3 x 3 determinant invariant). Remarkably, the zeros of the general G/sup t//sub q/ polynomial are in position and multiplicity exactly those of the SU(3) weight space associated with irreducible representation [q-1,t-1,0]. The results obtained are an essential step in the derivation of a fully explicit and comprehensible algebraic expression for all SU(3) WCG coefficients

Canonical Duality Theory for Topology Optimization

OpenAIRE

Gao, David Yang

2016-01-01

This paper presents a canonical duality approach for solving a general topology optimization problem of nonlinear elastic structures. By using finite element method, this most challenging problem can be formulated as a mixed integer nonlinear programming problem (MINLP), i.e. for a given deformation, the first-level optimization is a typical linear constrained 0-1 programming problem, while for a given structure, the second-level optimization is a general nonlinear continuous minimization pro...

Canonical treatment of the rocket with friction linear in the velocity

International Nuclear Information System (INIS)

Campos, I; Jimenez, J L; Valle, G del

2003-01-01

We show that the problem of the rocket with friction linear in the velocity can be treated by canonical methods. In order to achieve this we must abandon the restriction to natural Lagrangians of the form L = T - V, and use the method of S-equivalent Lagrangians. We also solve the problem with constant gravity. This example may be useful for the teaching of the application of canonical methods to dissipative systems, as well as to the teaching of the use of the method of S-equivalent Lagrangians

Quantum correction and ordering parameter for systems connected by a general point canonical transformation

International Nuclear Information System (INIS)

Yeon, Kyu Hwang; Hong, Suc Kyoung; Um, Chung In; George, Thomas F.

2006-01-01

With quantum operators corresponding to functions of the canonical variables, Schroedinger equations are constructed for systems corresponding to classical systems connected by a general point canonical transformation. Using the operator connecting quantum states between systems before and after the transformation, the quantum correction term and ordering parameter are obtained

Multivariate data analysis

Digital Repository Service at National Institute of Oceanography (India)

Fernandes, A.A.; Antony, M.K.; Somayajulu, Y.K.; Sarma, Y.V.B.; Almeida, A.M.; Mahadevan, R.

, Head Applied Statistics Unit, Indian Statistical Institute, Calcutta for going through the section on Canonical Correlation Analysis and offering his comments on the same. This report has been prepared using ?Latex? on a ?Linux? platform, viz...., the personal computer Kapila. I wish to thank Mr. Dattaram Shivji for installing ?Latex? and ?GMT? packages on the personal computer. The style file used for preparing this report, has been hacked by me from a Goa University, Ph. D style file prepared by Dr. D...

Bach, Beethoven, Bourdieu: "Cultural Capital" and the Scholastic Canon in England's A-Level Examinations

Science.gov (United States)

Legg, Robert

2012-01-01

This article applies Bourdieu's notion of "cultural capital" to historical, documentary research which investigates the construction of a scholastic canon within England's A-level music examinations. A digest of the ways in which this canon evolved between 1951 and 1986 is presented in support of the idea that examiners' responses to…

The Canon, the Web, and the Long Tail

DEFF Research Database (Denmark)

Sanderhoff, Merete

2017-01-01

This article argues that releasing images of artworks into the public domain creates a new possibility for the public to challenge the canon or create their own, based on access to previously inaccessible images. Through the dissemination of openly licensed artworks across the Internet, museums c...

Lie algebras under constraints and nonbijective canonical transformations

International Nuclear Information System (INIS)

Kibler, M.; Winternitz, P.

1987-10-01

The concept of a Lie algebra under constraints is developed in connection with the theory of nonbijective canonical transformations. A finite dimensional vector space M, carrying a faithful linear representation of a Lie algebra L, is mapped into a lower dimensional space antiM in such a maner that a subalgebra L 0 of L is mapped into D(L 0 ) = 0. The Lie algebra L under the constraint D(L 0 ) = 0 is the largest subalgebra L 1 of L that can be represented faithfully on antiM. If L 0 is semi-simple, then L 1 is shown to be the centraliser cent L L 0 . If L is semi-simple and L 0 is an one-dimensional diagonal subalgebra of a Cartan subalgebra of L, then L 1 is shown to be the factor algebra cent L L 0 /L 0 . The latter two results are applied to nonbijective canonical transformations generalizing the Kustaanheimo-Stiefel transformation

Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells

International Nuclear Information System (INIS)

Kordes, Claus; Sawitza, Iris; Haeussinger, Dieter

2008-01-01

It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the capacity to differentiate into cells of endothelial and hepatocyte lineages. The present study shows that β-catenin-dependent canonical Wnt signaling is active in freshly isolated HSC of rats. Mimicking of the canonical Wnt pathway in cultured HSC by TWS119, an inhibitor of the glycogen synthase kinase 3β, led to reduced β-catenin phosphorylation, induced nuclear translocation of β-catenin, elevated glutamine synthetase production, impeded synthesis of α-smooth muscle actin and Wnt5a, but promoted the expression of glial fibrillary acidic protein, Wnt10b, and paired-like homeodomain transcription factor 2c. In addition, canonical Wnt signaling lowered DNA synthesis and hindered HSC from entering the cell cycle. The findings demonstrate that β-catenin-dependent Wnt signaling maintains the quiescent state of HSC and, similar to stem and progenitor cells, influences their developmental fate

BOOK REVIEW: Canonical Gravity and Applications: Cosmology, Black Holes, and Quantum Gravity Canonical Gravity and Applications: Cosmology, Black Holes, and Quantum Gravity

Science.gov (United States)

Husain, Viqar

2012-03-01

Research on quantum gravity from a non-perturbative 'quantization of geometry' perspective has been the focus of much research in the past two decades, due to the Ashtekar-Barbero Hamiltonian formulation of general relativity. This approach provides an SU(2) gauge field as the canonical configuration variable; the analogy with Yang-Mills theory at the kinematical level opened up some research space to reformulate the old Wheeler-DeWitt program into what is now known as loop quantum gravity (LQG). The author is known for his work in the LQG approach to cosmology, which was the first application of this formalism that provided the possibility of exploring physical questions. Therefore the flavour of the book is naturally informed by this history. The book is based on a set of graduate-level lectures designed to impart a working knowledge of the canonical approach to gravitation. It is more of a textbook than a treatise, unlike three other recent books in this area by Kiefer [1], Rovelli [2] and Thiemann [3]. The style and choice of topics of these authors are quite different; Kiefer's book provides a broad overview of the path integral and canonical quantization methods from a historical perspective, whereas Rovelli's book focuses on philosophical and formalistic aspects of the problems of time and observables, and gives a development of spin-foam ideas. Thiemann's is much more a mathematical physics book, focusing entirely on the theory of representing constraint operators on a Hilbert space and charting a mathematical trajectory toward a physical Hilbert space for quantum gravity. The significant difference from these books is that Bojowald covers mainly classical topics until the very last chapter, which contains the only discussion of quantization. In its coverage of classical gravity, the book has some content overlap with Poisson's book [4], and with Ryan and Shepley's older work on relativistic cosmology [5]; for instance the contents of chapter five of the

Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling.

Science.gov (United States)

Danopoulos, Soula; Krainock, Michael; Toubat, Omar; Thornton, Matthew; Grubbs, Brendan; Al Alam, Denise

2016-12-01

Lung branching morphogenesis relies on a number of factors, including proper epithelial cell proliferation and differentiation, cell polarity, and migration. Rac1, a small Rho GTPase, orchestrates a number of these cellular processes, including cell proliferation and differentiation, cellular alignment, and polarization. Furthermore, Rac1 modulates both noncanonical and canonical Wnt signaling, important pathways in lung branching morphogenesis. Culture of embryonic mouse lung explants in the presence of the Rac1 inhibitor (NSC23766) resulted in a dose-dependent decrease in branching. Increased cell death and BrdU uptake were notably seen in the mesenchyme, while no direct effect on the epithelium was observed. Moreover, vasculogenesis was impaired following Rac1 inhibition as shown by decreased Vegfa expression and impaired LacZ staining in Flk1-Lacz reporter mice. Rac1 inhibition decreased Fgf10 expression in conjunction with many of its associated factors. Moreover, using the reporter lines TOPGAL and Axin2-LacZ, there was an evident decrease in canonical Wnt signaling in the explants treated with the Rac1 inhibitor. Activation of canonical Wnt pathway using WNT3a or WNT7b only partially rescued the branching inhibition. Moreover, these results were validated on human explants, where Rac1 inhibition resulted in impaired branching and decreased AXIN2 and FGFR2b expression. We therefore conclude that Rac1 regulates lung branching morphogenesis, in part through canonical Wnt signaling. However, the exact mechanisms by which Rac1 interacts with canonical Wnt in human and mouse lung requires further investigation. Copyright © 2016 the American Physiological Society.

On the zero temperature limit of the Kubo-transformed quantum time correlation function

Science.gov (United States)

Hernández de la Peña, Lisandro

2014-04-01

The zero temperature limit of several quantum time correlation functions is analysed. It is shown that while the canonical quantum time correlation function retains the full dynamical information as temperature approaches zero, the Kubo-transformed and the thermally symmetrised quantum time correlation functions lose all dynamical information at this limit. This is shown to be a consequence of the projection onto the ground state, via the limiting process of the quantities ? and ?, either together as a product, or separately. Although these findings would seem to suggest that finite-temperature methods commonly used to estimate Kubo correlation functions would be incapable of retaining any ground state dynamics, we propose a route for recovering in principle all dynamical information at the ground state. It is first shown that the usual frequency space relation between canonical and Kubo correlation functions also holds for microcanonical time correlation functions. Since the Kubo-transformed microcanonical correlation function can be obtained from the usual finite-temperature function by including a projection onto the corresponding microcanonical ensemble, finite-temperature methods, properly modified to incorporate such a constraint, can be used to capture full quantum dynamics at any arbitrary energy state, including the ground state. This approach is illustrated with the application of centroid dynamics to the ground state dynamics of the harmonic oscillator.

Morphometric and Phylogenic Analysis of Six Population Indonesian Local Goats

Directory of Open Access Journals (Sweden)

A. Batubara

2011-12-01

Full Text Available The research objectives were to characterize morphometric and genetic distance between populations of Indonesian local goats. The morphological discriminant and canonical analysis were carried out to estimate the phylogenic relationship and determine the discriminant variable between Benggala goats (n= 96, Marica (n= 60, Jawarandu (n= 94, (Kacang (n= 217, Muara (n= 30 and Samosir (n= 42. Discriminant analysis used to clasify body weight and body measurements. In the analysis of variance showed that body weight and body measurement (body length, height at withers, thorax width, thorax height, hert girth, skull width and height, tail length and width, ear length and width of Muara goats was higher (P<0.05 compared to the other groups, and the lowest was in Marica goats. The smallest genetic distance was between Marica and Samosir (11.207 and the highest were between Muara and Benggala (255.110. The highest similarity between individual within population was found in Kacang (99.28% and the lowest in Samosir (82.50%. The canonical analysis showed high correlation on canon circumference, body weight, skull width, skull height, and tail width variables so these six variables can be used as distinguishing variables among population. The result from Mahalonobis distance for phenogram tree and canonical analysis showed that six populations of Indonesian local goats were divided into six breed of goats: the first was Muara, the second was Jawarandu, the third was Kacang, the fourth was Benggala, the fifth was Samosir and the sixth was Marica goats. The diversity of body size and body weight of goats was observed quite large, so the chances of increasing productivity could be made through selection and mating programs.

Geometry of real and complex canonical transformations in quantum mechanics

International Nuclear Information System (INIS)

Grossmann, A.

1977-08-01

Quantum mechanics of finitely many particles involves the group of linear (and affine) canonical transformations. A well-defined ray representation of this group acts in the space of states of any quantum-mechanical system with finitely many degrees of freedom and plays a central role in many different contexts. This representation appears quite naturally in quantum mechanics over phase space (Weyl-Wigner correspondence), that it becomes, when suitably written, just a matter of looking at one object from different symplectic reference frames. This is particularly interesting for complex canonical transformations which are represented by unbounded operators. The list of references gives an idea of the variety of motivations and points of view in the subject

A Problem-Centered Approach to Canonical Matrix Forms

Science.gov (United States)

Sylvestre, Jeremy

2014-01-01

This article outlines a problem-centered approach to the topic of canonical matrix forms in a second linear algebra course. In this approach, abstract theory, including such topics as eigenvalues, generalized eigenspaces, invariant subspaces, independent subspaces, nilpotency, and cyclic spaces, is developed in response to the patterns discovered…

A grand-canonical ensemble of randomly triangulated surfaces

International Nuclear Information System (INIS)

Jurkiewicz, J.; Krzywicki, A.; Petersson, B.

1986-01-01

An algorithm is presented generating the grand-canonical ensemble of discrete, randomly triangulated Polyakov surfaces. The algorithm is used to calculate the susceptibility exponent, which controls the existence of the continuum limit of the considered model, for the dimensionality of the embedding space ranging from 0 to 20. (orig.)

Publication bias and the canonization of false facts

DEFF Research Database (Denmark)

Nissen, Silas Boye; Magidson, Tali; Gross, Kevin

2016-01-01

canonized as fact. Data-dredging, p-hacking, and similar behaviors exacerbate the problem. Should negative results become easier to publish as a claim approaches acceptance as a fact, however, true and false claims would be more readily distinguished. To the degree that the model reflects the real world...

An ACE-based Nonlinear Extension to Traditional Empirical Orthogonal Function Analysis

DEFF Research Database (Denmark)

Hilger, Klaus Baggesen; Nielsen, Allan Aasbjerg; Andersen, Ole

2001-01-01

This paper shows the application of the empirical orthogonal unctions/principal component transformation on global sea surface height and temperature data from 1996 and 1997. A nonlinear correlation analysis of the transformed data is proposed and performed by applying the alternating conditional...... expectations algorithm. New canonical variates are found that indicate that the highest correlation between ocean temperature and height is associated with the build-up of the El Niño during the last half of 1997....

Vanishing of local non-Gaussianity in canonical single field inflation

Science.gov (United States)

Bravo, Rafael; Mooij, Sander; Palma, Gonzalo A.; Pradenas, Bastián

2018-05-01

We study the production of observable primordial local non-Gaussianity in two opposite regimes of canonical single field inflation: attractor (standard single field slow-roll inflation) and non attractor (ultra slow-roll inflation). In the attractor regime, the standard derivation of the bispectrum's squeezed limit using co-moving coordinates gives the well known Maldacena's consistency relation fNL = 5 (1‑ns) / 12. On the other hand, in the non-attractor regime, the squeezed limit offers a substantial violation of this relation given by fNL = 5/2. In this work we argue that, independently of whether inflation is attractor or non-attractor, the size of the observable primordial local non-Gaussianity is predicted to be fNLobs = 0 (a result that was already understood to hold in the case of attractor models). To show this, we follow the use of the so-called Conformal Fermi Coordinates (CFC), recently introduced in the literature. These coordinates parametrize the local environment of inertial observers in a perturbed FRW spacetime, allowing one to identify and compute gauge invariant quantities, such as n-point correlation functions. Concretely, we find that during inflation, after all the modes have exited the horizon, the squeezed limit of the 3-point correlation function of curvature perturbations vanishes in the CFC frame, regardless of the inflationary regime. We argue that such a cancellation should persist after inflation ends.

The Canonical Black Body: Alternative African American Religions and the Disruptive Politics of Sacrality

Directory of Open Access Journals (Sweden)

Joseph L. Tucker Edmonds

2018-01-01

Full Text Available “The Canonical Black Body” argues that central to the study of African American religions is a focus on the black body and the production and engagement of canons on the sacred black body within the black public sphere. Furthermore, this essay suggests that, by paying attention to alternative African American religions in the twentieth century, we can better engage the relationship between African American religion and the long history of creating these canons on the black body, debating their relationship to black freedom, and circulating the canons to contest the oppressive, exclusive practices of modern democracy. Through a critical engagement of the fields of Black Theology and New Religious Movements and using the resources offered by Delores Williams’ accounts of variety and experience and Vincent Wimbush’s category of signifying, this essay will argue for how a return to the body provides resources and tools for not only theorizing African American religions but thinking about the production and creation of competing black publics, including the important role of alternative black sacred publics.

Power, Gender, and Canon Formation in Mexico

Directory of Open Access Journals (Sweden)

Cynthia Steele

1996-01-01

Full Text Available I propose to analyze Castellanos's trajectory from marginalized ethnographer and critic of "latino" society, to presidential insider and ambassador, and the first modern Mexican woman writer to be accepted into the literary canon. I will explore the intersection of politics, gender, and the (self- creation of a literary persona with regard to the following issues: 1 the tension between self-exposure and self-censorship in Castellanos's literary work; 2 Castellanos's intense and problematic relationship with her illegitimate, mestizo half-brother; 3 the coincidences and contradictions between Castellanos's journalistic account of her relationship with her servant Maria Escandon, and Maria's own oral history twenty years later; 4 the tension between depression and dependency, on the one hand, and self-assertiveness and audacity, on the other; 5 the relation between Castellanos's role as ambassador and the personal, apolitical, often frivolous character of her journalistic articles written in Israel; 6 the contradictory readings of Castellanos's death, and the respective implications for her place in the canon; and 7 the implications, for their reception, of the love letters published in Cartas a Ricardo 1994, as opposed to 1974.

Study on linear canonical transformation in a framework of a phase space representation of quantum mechanics

International Nuclear Information System (INIS)

Raoelina Andriambololona; Ranaivoson, R.T.R.; Rakotoson, H.; Solofoarisina, W.C.

2015-04-01

We present a study on linear canonical transformation in the framework of a phase space representation of quantum mechanics that we have introduced in our previous work. We begin with a brief recall about the so called phase space representation. We give the definition of linear canonical transformation with the transformation law of coordinate and momentum operators. We establish successively the transformation laws of mean values, dispersions, basis state and wave functions.Then we introduce the concept of isodispersion linear canonical transformation.

New constraints for canonical general relativity

International Nuclear Information System (INIS)

Reisenberger, M.P.

1995-01-01

Ashtekar's canonical theory of classical complex Euclidean GR (no Lorentzian reality conditions) is found to be invariant under the full algebra of infinitesimal 4-diffeomorphisms, but non-invariant under some finite proper 4-diffeos when the densitized dreibein, E a i , is degenerate. The breakdown of 4-diffeo invariance appears to be due to the inability of the Ashtekar Hamiltonian to generate births and deaths of E flux loops (leaving open the possibility that a new 'causality condition' forbidding the birth of flux loops might justify the non-invariance of the theory).A fully 4-diffeo invariant canonical theory in Ashtekar's variables, derived from Plebanski's action, is found to have constraints that are stronger than Ashtekar's for rank E< 2. The corresponding Hamiltonian generates births and deaths of E flux loops.It is argued that this implies a finite amplitude for births and deaths of loops in the physical states of quantum GR in the loop representation, thus modifying this (partly defined) theory substantially.Some of the new constraints are second class, leading to difficulties in quantization in the connection representation. This problem might be overcome in a very nice way by transforming to the classical loop variables, or the 'Faraday line' variables of Newman and Rovelli, and then solving the offending constraints.Note that, though motivated by quantum considerations, the present paper is classical in substance. (orig.)

Canonical Groups for Quantization on the Two-Dimensional Sphere and One-Dimensional Complex Projective Space

International Nuclear Information System (INIS)

Sumadi A H A; H, Zainuddin

2014-01-01

Using Isham's group-theoretic quantization scheme, we construct the canonical groups of the systems on the two-dimensional sphere and one-dimensional complex projective space, which are homeomorphic. In the first case, we take SO(3) as the natural canonical Lie group of rotations of the two-sphere and find all the possible Hamiltonian vector fields, and followed by verifying the commutator and Poisson bracket algebra correspondences with the Lie algebra of the group. In the second case, the same technique is resumed to define the Lie group, in this case SU (2), of CP'.We show that one can simply use a coordinate transformation from S 2 to CP 1 to obtain all the Hamiltonian vector fields of CP 1 . We explicitly show that the Lie algebra structures of both canonical groups are locally homomorphic. On the other hand, globally their corresponding canonical groups are acting on different geometries, the latter of which is almost complex. Thus the canonical group for CP 1 is the double-covering group of SO(3), namely SU(2). The relevance of the proposed formalism is to understand the idea of CP 1 as a space of where the qubit lives which is known as a Bloch sphere

ACTIVITY OF CANONICAL WNT SIGNAL SYSTEM IN HYALINE CARTILAGE ARTICULAR CHONDROCYTES IN PROCESS OF SYNOVIAL JOINT DEVELOPMENT

Directory of Open Access Journals (Sweden)

A.O. Molotkov

2009-03-01

Full Text Available Canonical and non-canonical Wnt systems are essential regulators of chondrogenesis and bone development. However, the roles of these systems in synovial joint development are not well studied. To determine if canonical Wnt system is active in developing articular chondrocytes we used immunohistochemistry for в-galactosidase and doublecortin (cell-type specific marker for articular chondrocytes to double label sections through joint regions of E14.5, E18.5, P10 and adult mice. Here the following results are presented. Canonical Wnt signal system does not work in developing articular chondrocytes at early embryonic stages (E14.5; it is active in the articular chondrocytes at late embryonic stages (E16.5-E18.5 and during postnatal development (P7-P10, but is turned off again in the adult articular chondrocytes. These results suggest that canonical Wnt signaling is being regulated during articular chondrocytes differentiation and joint formation.

Application of Canonical Effective Methods to Background-Independent Theories

Science.gov (United States)

Buyukcam, Umut

Effective formalisms play an important role in analyzing phenomena above some given length scale when complete theories are not accessible. In diverse exotic but physically important cases, the usual path-integral techniques used in a standard Quantum Field Theory approach seldom serve as adequate tools. This thesis exposes a new effective method for quantum systems, called the Canonical Effective Method, which owns particularly wide applicability in backgroundindependent theories as in the case of gravitational phenomena. The central purpose of this work is to employ these techniques to obtain semi-classical dynamics from canonical quantum gravity theories. Application to non-associative quantum mechanics is developed and testable results are obtained. Types of non-associative algebras relevant for magnetic-monopole systems are discussed. Possible modifications of hypersurface deformation algebra and the emergence of effective space-times are presented. iii.

Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

International Nuclear Information System (INIS)

Kim, Byeong-Moo; Choi, Michael Y.

2012-01-01

Highlights: ► Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. ► miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. ► miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. ► miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. ► miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3′-untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

Il canone linguistico boccacciano, non senza dissenso

Directory of Open Access Journals (Sweden)

Cecilia Casini

2015-06-01

Full Text Available Author of prose’s greatest masterpiece of medieval literature in the vernacular, Giovanni Boccaccio was crucial to defining the Italian language canon, especially since Pietro Bembo proposed its coding in the sixteenth century. Not without controversy, however, since shortly after the publication of Prose Della Volgar Language, Bembo presents the first contrasting theories that support the linguistic model presented by Machiavelli

Canonical formulation of IIB D-branes

International Nuclear Information System (INIS)

Kamimura, K.

1998-01-01

We find Wess-Zumino actions for kappa invariant type IIB D-branes in explicit forms. A simple and compact expression is obtained by the use of spinor variables which are defined as power series of differential forms. Using the Wess-Zumino actions we develop the canonical formulation and find the complete set of the constraint equations for generic type IIB Dp-branes. The conserved global supersymmetry charges are determined and the algebra containing the central charges can be obtained explicitly. (orig.)

Canonical transformations and hamiltonian path integrals

International Nuclear Information System (INIS)

Prokhorov, L.V.

1982-01-01

Behaviour of the Hamiltonian path integrals under canonical transformations produced by a generator, is investigated. An exact form is determined for the kernel of the unitary operator realizing the corresponding quantum transformation. Equivalence rules are found (the Hamiltonian formalism, one-dimensional case) enabling one to exclude non-standard terms from the action. It is shown that the Hamiltonian path integral changes its form under cononical transformations: in the transformed expression besides the classical Hamiltonian function there appear some non-classical terms

An algorithm for calculation of the Jordan canonical form of a matrix

Science.gov (United States)

Sridhar, B.; Jordan, D.

1973-01-01

Jordan canonical forms are used extensively in the literature on control systems. However, very few methods are available to compute them numerically. Most numerical methods compute a set of basis vectors in terms of which the given matrix is diagonalized when such a change of basis is possible. Here, a simple and efficient method is suggested for computing the Jordan canonical form and the corresponding transformation matrix. The method is based on the definition of a generalized eigenvector, and a natural extension of Gauss elimination techniques.

The generalized Q-S synchronization between the generalized Lorenz canonical form and the Roessler system

International Nuclear Information System (INIS)

Yang Yunqing; Chen Yong

2009-01-01

In this paper, we investigate the generalized Q-S synchronization between the generalized Lorenz canonical form and the Roessler system. Firstly, we transform an arbitrary generalized Lorenz system to the generalized Lorenz canonical form, and the relation between the parameter of the generalized Lorenz system and the parameter of the generalized Lorenz canonical form are shown. Secondly, we extend the scheme present by [Yan ZY. Chaos 2005;15:023902] to study the generalized Q-S synchronization between the generalized Lorenz canonical form and the Roessler system, the more general controller is obtained. By choosing different parameter in the generalized controller obtained here, without much extra effort, we can get the controller of synchronization between the Chen system and the Roessler system, the Lue system and the Roessler system, the classic Lorenz system and the Roessler system, the Hyperbolic Lorenz system and the Roessler system, respectively. Finally, numerical simulations are used to perform such synchronization and verify the effectiveness of the controller.

On the completeness of the canonical reductions from Kac-Moody to W-algebras

International Nuclear Information System (INIS)

McGlinn, W.

1997-01-01

We study the question as to whether the canonical reductions of Kac-Moody (KM) algebras to W-algebras are exhaustive. We first review and consolidate previous results. In particular we show that, apart from the two lowest grades, the canonical reductions are the only ones that respect the physically reasonable requirement that the W-algebra have no negative conformal weights. We then break new ground by formulating a condition that the W-algebra be differential polynomial. We apply the condition that the W-algebra be polynomial (in a particular gauge) and primary to the groups SL(N,R) with integral SL(2,R) embeddings. We find that, subject to some reasonable technical assumptions, the canonical reductions are exhaustive (except possibly at grade one). The derivation suggests that similar results hold for the other classes of simple groups. (orig.)

Transforming Growth Factor β Activation Primes Canonical Wnt Signaling Through Down-Regulation of Axin-2.

Science.gov (United States)

Gillespie, Justin; Ross, Rebecca L; Corinaldesi, Clarissa; Esteves, Filomena; Derrett-Smith, Emma; McDermott, Michael F; Doody, Gina M; Denton, Christopher P; Emery, Paul; Del Galdo, Francesco

2018-02-06

Aberrant activation of Wnt signaling has been observed in tissues from patients with systemic sclerosis (SSc). This study aimed to determine the role of transforming growth factor β (TGFβ) in driving the increased Wnt signaling, through modulation of axis inhibition protein 2 (Axin-2), a critical regulator of the Wnt canonical pathway. Canonical Wnt signaling activation was analyzed by TOPflash T cell factor/lymphoid enhancer factor promoter assays. Axin-2 was evaluated in vitro by analysis of Axin-2 primary/mature transcript expression and decay, TGFβ receptor type I (TGFβRI) blockade, small interfering RNA-mediated depletion of tristetraprolin 1, and XAV-939-mediated Axin-2 stabilization. In vivo, Axin-2 messenger RNA (mRNA) and protein expression was determined in skin and lung biopsy samples from mice that express a kinase-deficient TGFβRII specifically on fibroblasts (TβRIIΔk-fib-transgenic mice) and from littermate controls. SSc fibroblasts displayed an increased response to canonical Wnt ligands despite basal levels of Wnt signaling that were comparable to those in healthy control fibroblasts in vitro. Notably, we showed that SSc fibroblasts had reduced basal expression of Axin-2, which was caused by an endogenous TGFβ-dependent increase in Axin-2 mRNA decay. Accordingly, we observed that TGFβ decreased Axin-2 expression both in vitro in healthy control fibroblasts and in vivo in TβRIIΔk-fib-transgenic mice. Additionally, using Axin-2 gain- and loss-of-function experiments, we demonstrated that the TGFβ-induced increased response to Wnt activation characteristic of SSc fibroblasts depended on reduced bioavailability of Axin-2. This study highlights the importance of reduced bioavailability of Axin-2 in mediating the increased canonical Wnt response observed in SSc fibroblasts. This novel mechanism extends our understanding of the processes involved in Wnt/β-catenin-driven pathology and supports the rationale for targeting the TGFβ pathway

Identifying the source of fluvial terrace deposits using XRF scanning and Canonical Discriminant Analysis: A case study of the Chihshang terraces, eastern Taiwan

Science.gov (United States)

Chang, Queenie; Lee, Jian-Cheng; Hunag, Jyh-Jaan; Wei, Kuo-Yen; Chen, Yue-Gau; Byrne, Timothy B.

2018-05-01

The source of fluvial deposits in terraces provides important information about the catchment fluvial processes and landform evolution. In this study, we propose a novel approach that combines high-resolution Itrax-XRF scanning and Canonical Discriminant Analysis (CDA) to identify the source of fine-grained fluvial terrace deposits. We apply this approach to a group of terraces that are located on the hanging wall of the Chihshang Fault in eastern Taiwan with two possible sources, the Coastal Range on the east and the Central Range on the west. Our results of standard samples from the two potential sources show distinct ranges of canonical variables, which provided a better separation ability than individual chemical elements. We then tested the possibility of using this approach by applying it to several samples with known sediment sources and obtain positive results. Applying this same approach to the fine-grained sediments in Chihshang terraces indicates that they are mostly composed of Coastal Range material but also contain some inputs from the Central Range. In two lowest terraces T1 and T2, the fine-grained deposits show significant Central Range component. For terrace T4, the results show less Central Range input and a trend of decreasing Central Range influences up section. The Coastal Range material becomes dominant in the two highest terraces T7 and T10. Sediments in terrace T5 appear to have been potentially altered by post-deposition chemical alteration processes and are not included in the analysis. Our results show that the change in source material in the terraces deposits was relatively gradual rather than the sharp changes suggested by the composition of the gravels and conglomerates. We suggest that this change in sources is related to the change in dominant fluvial processes that controlled by the tectonic activity.

Connecting the Canon to Current Young Adult Literature

Science.gov (United States)

Rybakova, Katie; Roccanti, Rikki

2016-01-01

In this article we discuss the respective roles of young adult literature and literary texts in the secondary level English Language Arts classroom and explore the connections that can be made between popular young adult books and the traditional canon. We provide examples showing how young adult literature bestsellers such as "The Book…

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

Directory of Open Access Journals (Sweden)

Joseph L. Regan

2017-12-01

Full Text Available Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs. To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in a panel of patient-derived cancer organoids. These studies demonstrated cancer organoids to be enriched for CSCs, which varied in frequency between tumors. Whole-transcriptome analysis identified WNT and Hedgehog signaling components to be enhanced in CSC-enriched tumors and in aldehyde dehydrogenase (ALDH-positive CSCs. Canonical GLI-dependent Hedgehog signaling is a negative regulator of WNT signaling in normal intestine and intestinal tumors. Here, we show that Hedgehog signaling in colon CSCs is autocrine SHH-dependent, non-canonical PTCH1 dependent, and GLI independent. In addition, using small-molecule inhibitors and RNAi against SHH-palmitoylating Hedgehog acyltransferase (HHAT, we demonstrate that non-canonical Hedgehog signaling is a positive regulator of WNT signaling and required for colon CSC survival. : Colon cancer is a heterogeneous tumor driven by a subpopulation(s of therapy-resistant cancer stem cells (CSCs. Regan et al. use 3D culture models to demonstrate that CSC survival is regulated by non-canonical, SHH-dependent, PTCH1-dependent Hedgehog signaling, which acts as a positive regulator of WNT signaling to block CSC differentiation. Keywords: WNT pathway, non-canonical Hedgehog signaling, cancer stem cell, colon cancer, cancer organoid, PTCH1, HHAT, SHH

The canonical way to make a heart: β-catenin and plakoglobin in heart development and remodeling.

Science.gov (United States)

Piven, Oksana O; Winata, Cecilia L

2017-12-01

The main mediator of the canonical Wnt pathway, β-catenin, is a major effector of embryonic development, postnatal tissue homeostasis, and adult tissue regeneration. The requirement for β-catenin in cardiogenesis and embryogenesis has been well established. However, many questions regarding the molecular mechanisms by which β-catenin and canonical Wnt signaling regulate these developmental processes remain unanswered. An interesting question that emerged from our studies concerns how β-catenin signaling is modulated through interaction with other factors. Recent experimental data implicate new players in canonical Wnt signaling, particularly those which modulate β-catenin function in many its biological processes, including cardiogenesis. One of the interesting candidates is plakoglobin, a little-studied member of the catenin family which shares several mechanistic and functional features with its close relative, β-catenin. Here we have focused on the function of β-catenin in cardiogenesis. We also summarize findings on plakoglobin signaling function and discuss possible interplays between β-catenin and plakoglobin in the regulation of embryonic heart development. Impact statement Heart development, function, and remodeling are complex processes orchestrated by multiple signaling networks. This review examines our current knowledge of the role of canonical Wnt signaling in cardiogenesis and heart remodeling, focusing primarily on the mechanistic action of its effector β-catenin. We summarize the generally accepted understanding of the field based on experimental in vitro and in vivo data, and address unresolved questions in the field, specifically relating to the role of canonical Wnt signaling in heart maturation and regeneration. What are the modulators of canonical Wnt, and particularly what are the potential roles of plakoglobin, a close relative of β-catenin, in regulating Wnt signaling?Answers to these questions will enhance our understanding of the

Using k-Mix-Neighborhood Subdigraphs to Compute Canonical Labelings of Digraphs

Directory of Open Access Journals (Sweden)

Jianqiang Hao

2017-02-01

Full Text Available This paper presents a novel theory and method to calculate the canonical labelings of digraphs whose definition is entirely different from the traditional definition of Nauty. It indicates the mutual relationships that exist between the canonical labeling of a digraph and the canonical labeling of its complement graph. It systematically examines the link between computing the canonical labeling of a digraph and the k-neighborhood and k-mix-neighborhood subdigraphs. To facilitate the presentation, it introduces several concepts including mix diffusion outdegree sequence and entire mix diffusion outdegree sequences. For each node in a digraph G, it assigns an attribute m_NearestNode to enhance the accuracy of calculating canonical labeling. The four theorems proved here demonstrate how to determine the first nodes added into M a x Q ( G . Further, the other two theorems stated below deal with identifying the second nodes added into M a x Q ( G . When computing C m a x ( G , if M a x Q ( G already contains the first i vertices u 1 , u 2 , ⋯ , u i , Diffusion Theorem provides a guideline on how to choose the subsequent node of M a x Q ( G . Besides, the Mix Diffusion Theorem shows that the selection of the ( i + 1 th vertex of M a x Q ( G for computing C m a x ( G is from the open mix-neighborhood subdigraph N + + ( Q of the nodes set Q = { u 1 , u 2 , ⋯ , u i } . It also offers two theorems to calculate the C m a x ( G of the disconnected digraphs. The four algorithms implemented in it illustrate how to calculate M a x Q ( G of a digraph. Through software testing, the correctness of our algorithms is preliminarily verified. Our method can be utilized to mine the frequent subdigraph. We also guess that if there exists a vertex v ∈ S + ( G satisfying conditions C m a x ( G − v ⩽ C m a x ( G − w for each w ∈ S + ( G ∧ w ≠ v , then u 1 = v for M a x Q ( G .

Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression.

Directory of Open Access Journals (Sweden)

Ana Gracanin

Full Text Available Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model organism for breast cancer research. In order to obtain an insight into underlying signaling mechanisms during canine mammary tumorigenesis, in this study we assessed the incidence and the mechanism of canonical Wnt activation in a panel of 12 canine mammary tumor cell lines. We show that a subset of canine mammary cell lines exhibit a moderate canonical Wnt activity that is dependent on Wnt ligands, similar to what has been described in human breast cancer cell lines. In addition, three of the tested canine mammary cell lines have a high canonical Wnt activity that is not responsive to inhibitors of Wnt ligand secretion. Tumor cell lines with highly active canonical Wnt signaling often carry mutations in key members of the Wnt signaling cascade. These cell lines, however, carry no mutations in the coding regions of intracellular Wnt pathway components (APC, β-catenin, GSK3β, CK1α and Axin1 and have a functional β-catenin destruction complex. Interestingly, however, the cell lines with high canonical Wnt activity specifically overexpress LEF1 mRNA and the knock-down of LEF1 significantly inhibits TCF-reporter activity. In addition, LEF1 is overexpressed in a subset of canine mammary carcinomas, implicating LEF1 in ligand-independent activation of canonical Wnt signaling in canine mammary tumors. We conclude that canonical Wnt activation may be a frequent event in canine mammary tumors both through Wnt ligand-dependent and novel ligand-independent mechanisms.

Autonomy, Submission or Sound Hybridization? The Construction of the Aesthetic Canon of the Spanish Pop-Rock

Directory of Open Access Journals (Sweden)

JAVIER NOYA

2014-01-01

Full Text Available This paper provides an approach to the aesthetic canon of Spanish pop-rock, which is understood as being the musicians, bands and works which have had the most infl uence on this musical genre in Spain. Using Bourdieu?s sociology of art and its application to popular music studies, surveys have been analysed that were carried out by both Spanish music critics and musicians. The hypothesis posed is whether an autochthonous aesthetic canon exists, and whether this is determined by an Anglo- American influence. From lists or rankings published whether in books or in general or specialist magazines, these data were combined to obtain a meta-ranking, which was tested by using certain statistical tests. From this, some characteristics particular to the Spanish aesthetic canon have been obtained, as well as some which are shared with the Englishspeaking canon.

Grand canonical electronic density-functional theory: Algorithms and applications to electrochemistry

International Nuclear Information System (INIS)

Sundararaman, Ravishankar; Goddard, William A. III; Arias, Tomas A.

2017-01-01

First-principles calculations combining density-functional theory and continuum solvation models enable realistic theoretical modeling and design of electrochemical systems. When a reaction proceeds in such systems, the number of electrons in the portion of the system treated quantum mechanically changes continuously, with a balancing charge appearing in the continuum electrolyte. A grand-canonical ensemble of electrons at a chemical potential set by the electrode potential is therefore the ideal description of such systems that directly mimics the experimental condition. We present two distinct algorithms: a self-consistent field method and a direct variational free energy minimization method using auxiliary Hamiltonians (GC-AuxH), to solve the Kohn-Sham equations of electronic density-functional theory directly in the grand canonical ensemble at fixed potential. Both methods substantially improve performance compared to a sequence of conventional fixed-number calculations targeting the desired potential, with the GC-AuxH method additionally exhibiting reliable and smooth exponential convergence of the grand free energy. Lastly, we apply grand-canonical density-functional theory to the under-potential deposition of copper on platinum from chloride-containing electrolytes and show that chloride desorption, not partial copper monolayer formation, is responsible for the second voltammetric peak.

Grand canonical electronic density-functional theory: Algorithms and applications to electrochemistry

Science.gov (United States)

Sundararaman, Ravishankar; Goddard, William A.; Arias, Tomas A.

2017-03-01

First-principles calculations combining density-functional theory and continuum solvation models enable realistic theoretical modeling and design of electrochemical systems. When a reaction proceeds in such systems, the number of electrons in the portion of the system treated quantum mechanically changes continuously, with a balancing charge appearing in the continuum electrolyte. A grand-canonical ensemble of electrons at a chemical potential set by the electrode potential is therefore the ideal description of such systems that directly mimics the experimental condition. We present two distinct algorithms: a self-consistent field method and a direct variational free energy minimization method using auxiliary Hamiltonians (GC-AuxH), to solve the Kohn-Sham equations of electronic density-functional theory directly in the grand canonical ensemble at fixed potential. Both methods substantially improve performance compared to a sequence of conventional fixed-number calculations targeting the desired potential, with the GC-AuxH method additionally exhibiting reliable and smooth exponential convergence of the grand free energy. Finally, we apply grand-canonical density-functional theory to the under-potential deposition of copper on platinum from chloride-containing electrolytes and show that chloride desorption, not partial copper monolayer formation, is responsible for the second voltammetric peak.

Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.

Science.gov (United States)

Bedse, Gaurav; Hartley, Nolan D; Neale, Emily; Gaulden, Andrew D; Patrick, Toni A; Kingsley, Philip J; Uddin, Md Jashim; Plath, Niels; Marnett, Lawrence J; Patel, Sachin

2017-10-01

Increasing the available repertoire of effective treatments for mood and anxiety disorders represents a critical unmet need. Pharmacological augmentation of endogenous cannabinoid (eCB) signaling has been suggested to represent a novel approach to the treatment of anxiety disorders; however, the functional interactions between two canonical eCB pathways mediated via anandamide (N-arachidonylethanolamine [AEA]) and 2-arachidonoylglycerol (2-AG) in the regulation of anxiety are not well understood. We utilized pharmacological augmentation and depletion combined with behavioral and electrophysiological approaches to probe the role of 2-AG signaling in the modulation of stress-induced anxiety and the functional redundancy between AEA and 2-AG signaling in the modulation of anxiety-like behaviors in mice. Selective 2-AG augmentation reduced anxiety in the light/dark box assay and prevented stress-induced increases in anxiety associated with limbic AEA deficiency. In contrast, acute 2-AG depletion increased anxiety-like behaviors, which was normalized by selective pharmacological augmentation of AEA signaling and via direct cannabinoid receptor 1 stimulation with Δ 9 -tetrahydrocannabinol. Electrophysiological studies revealed 2-AG modulation of amygdala glutamatergic transmission as a key synaptic correlate of the anxiolytic effects of 2-AG augmentation. Although AEA and 2-AG likely subserve distinct physiological roles, a pharmacological and functional redundancy between these canonical eCB signaling pathways exists in the modulation of anxiety-like behaviors. These data support development of eCB-based treatment approaches for mood and anxiety disorders and suggest a potentially wider therapeutic overlap between AEA and 2-AG augmentation approaches than was previously appreciated. Copyright © 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling.

Science.gov (United States)

Bischoff, David S; Zhu, Jian-Hua; Makhijani, Nalini S; Yamaguchi, Dean T

2015-12-26

To investigate the effect of secreted frizzled-related proteins (sFRPs) on CXC chemokine expression in human mesenchymal stem cells (hMSCs). CXC chemokines such as CXCL5 and CXCL8 are induced in hMSCs during differentiation with osteogenic differentiation medium (OGM) and may be involved in angiogenic stimulation during bone repair. hMSCs were treated with conditioned medium (CM) from L-cells expressing non-canonical Wnt5a protein, or with control CM from wild type L-cells, or directly with sFRPs for up to 10 d in culture. mRNA expression levels of both CXCL5 and CXCL8 were quantitated by real-time reverse transcriptase-polymerase chain reaction and secreted protein levels of these proteins determined by ELISA. Dose- (0-500 ng/mL) and time-response curves were generated for treatment with sFRP1. Signal transduction pathways were explored by western blot analysis with pan- or phosphorylation-specific antibodies, through use of specific pathway inhibitors, and through use of siRNAs targeting specific frizzled receptors (Fzd)-2 and 5 or the receptor tyrosine kinase-like orphan receptor-2 (RoR2) prior to treatment with sFRPs. CM from L-cells expressing Wnt5a, a non-canonical Wnt, stimulated an increase in CXCL5 mRNA expression and protein secretion in comparison to control L-cell CM. sFRP1, which should inhibit both canonical and non-canonical Wnt signaling, surprisingly enhanced the expression of CXCL5 at 7 and 10 d. Dickkopf1, an inhibitor of canonical Wnt signaling prevented the sFRP-stimulated induction of CXCL5 and actually inhibited basal levels of CXCL5 expression at 7 but not at 10 d post treatment. In addition, all four sFRPs isoforms induced CXCL8 expression in a dose- and time-dependent manner with maximum expression at 7 d with treatment at 150 ng/mL. The largest increases in CXCL5 expression were seen from stimulation with sFRP1 or sFRP2. Analysis of mitogen-activated protein kinase signaling pathways in the presence of OGM showed sFRP1-induced

Newton equation for canonical, Lie-algebraic, and quadratic deformation of classical space

International Nuclear Information System (INIS)

Daszkiewicz, Marcin; Walczyk, Cezary J.

2008-01-01

The Newton equation describing particle motion in a constant external field force on canonical, Lie-algebraic, and quadratic space-time is investigated. We show that for canonical deformation of space-time the dynamical effects are absent, while in the case of Lie-algebraic noncommutativity, when spatial coordinates commute to the time variable, the additional acceleration of the particle is generated. We also indicate that in the case of spatial coordinates commuting in a Lie-algebraic way, as well as for quadratic deformation, there appear additional velocity and position-dependent forces

Grand Canonical Ensembles in General Relativity

International Nuclear Information System (INIS)

Klein, David; Yang, Wei-Shih

2012-01-01

We develop a formalism for general relativistic, grand canonical ensembles in space-times with timelike Killing fields. Using that, we derive ideal gas laws, and show how they depend on the geometry of the particular space-times. A systematic method for calculating Newtonian limits is given for a class of these space-times, which is illustrated for Kerr space-time. In addition, we prove uniqueness of the infinite volume Gibbs measure, and absence of phase transitions for a class of interaction potentials in anti-de Sitter space.

Canonical particle tracking in undulator fields

International Nuclear Information System (INIS)

Wuestefeld, G.; Bahrdt, J.

1991-01-01

A new algebraic mapping routine for particle tracking across wiggler and undulator fields in presented. It is based on a power series expansion of the generating function to guarantee fully canonical transformations. This method is 10 to 100 times faster than integration routines, applied in tracking codes like BETA or RACETRACK. The tracking method presented is not restricted to wigglers and undulators, it can be applied to other magnetic fields as well such as fringing fields of quadrupoles or dipoles if the suggested expansion converges

Canonical transformation path to gauge theories of gravity

Science.gov (United States)

Struckmeier, J.; Muench, J.; Vasak, D.; Kirsch, J.; Hanauske, M.; Stoecker, H.

2017-06-01

In this paper, the generic part of the gauge theory of gravity is derived, based merely on the action principle and on the general principle of relativity. We apply the canonical transformation framework to formulate geometrodynamics as a gauge theory. The starting point of our paper is constituted by the general De Donder-Weyl Hamiltonian of a system of scalar and vector fields, which is supposed to be form-invariant under (global) Lorentz transformations. Following the reasoning of gauge theories, the corresponding locally form-invariant system is worked out by means of canonical transformations. The canonical transformation approach ensures by construction that the form of the action functional is maintained. We thus encounter amended Hamiltonian systems which are form-invariant under arbitrary spacetime transformations. This amended system complies with the general principle of relativity and describes both, the dynamics of the given physical system's fields and their coupling to those quantities which describe the dynamics of the spacetime geometry. In this way, it is unambiguously determined how spin-0 and spin-1 fields couple to the dynamics of spacetime. A term that describes the dynamics of the "free" gauge fields must finally be added to the amended Hamiltonian, as common to all gauge theories, to allow for a dynamic spacetime geometry. The choice of this "dynamics" Hamiltonian is outside of the scope of gauge theory as presented in this paper. It accounts for the remaining indefiniteness of any gauge theory of gravity and must be chosen "by hand" on the basis of physical reasoning. The final Hamiltonian of the gauge theory of gravity is shown to be at least quadratic in the conjugate momenta of the gauge fields—this is beyond the Einstein-Hilbert theory of general relativity.

Probing the canonicity of the Wnt/Wingless signaling pathway.

Directory of Open Access Journals (Sweden)

Alexandra Franz

2017-04-01

Full Text Available The hallmark of canonical Wnt signaling is the transcriptional induction of Wnt target genes by the beta-catenin/TCF complex. Several studies have proposed alternative interaction partners for beta-catenin or TCF, but the relevance of potential bifurcations in the distal Wnt pathway remains unclear. Here we study on a genome-wide scale the requirement for Armadillo (Arm, Drosophila beta-catenin and Pangolin (Pan, Drosophila TCF in the Wnt/Wingless(Wg-induced transcriptional response of Drosophila Kc cells. Using somatic genetics, we demonstrate that both Arm and Pan are absolutely required for mediating activation and repression of target genes. Furthermore, by means of STARR-sequencing we identified Wnt/Wg-responsive enhancer elements and found that all responsive enhancers depend on Pan. Together, our results confirm the dogma of canonical Wnt/Wg signaling and argue against the existence of distal pathway branches in this system.

Canonical form of Euler-Lagrange equations and gauge symmetries

Energy Technology Data Exchange (ETDEWEB)

Geyer, B [Naturwissenschaftlich-Theoretisches Zentrum und Institut fuer Theoretische Physik, Universitaet Leipzig, Leipzig (Germany); Gitman, D M [Institute of Physics, University of Sao Paulo, Sao Paulo (Brazil); Tyutin, I V [Lebedev Physics Institute, Moscow (Russian Federation)

2003-06-13

The structure of the Euler-Lagrange equations for a general Lagrangian theory (e.g. singular, with higher derivatives) is studied. For these equations we present a reduction procedure to the so-called canonical form. In the canonical form the equations are solved with respect to highest-order derivatives of nongauge coordinates, whereas gauge coordinates and their derivatives enter the right-hand sides of the equations as arbitrary functions of time. The reduction procedure reveals constraints in the Lagrangian formulation of singular systems and, in that respect, is similar to the Dirac procedure in the Hamiltonian formulation. Moreover, the reduction procedure allows one to reveal the gauge identities between the Euler-Lagrange equations. Thus, a constructive way of finding all the gauge generators within the Lagrangian formulation is presented. At the same time, it is proved that for local theories all the gauge generators are local in time operators.

Geometric integrator for simulations in the canonical ensemble

Energy Technology Data Exchange (ETDEWEB)

Tapias, Diego, E-mail: diego.tapias@nucleares.unam.mx [Departamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510 (Mexico); Sanders, David P., E-mail: dpsanders@ciencias.unam.mx [Departamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510 (Mexico); Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139 (United States); Bravetti, Alessandro, E-mail: alessandro.bravetti@iimas.unam.mx [Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510 (Mexico)

2016-08-28

We introduce a geometric integrator for molecular dynamics simulations of physical systems in the canonical ensemble that preserves the invariant distribution in equations arising from the density dynamics algorithm, with any possible type of thermostat. Our integrator thus constitutes a unified framework that allows the study and comparison of different thermostats and of their influence on the equilibrium and non-equilibrium (thermo-)dynamic properties of a system. To show the validity and the generality of the integrator, we implement it with a second-order, time-reversible method and apply it to the simulation of a Lennard-Jones system with three different thermostats, obtaining good conservation of the geometrical properties and recovering the expected thermodynamic results. Moreover, to show the advantage of our geometric integrator over a non-geometric one, we compare the results with those obtained by using the non-geometric Gear integrator, which is frequently used to perform simulations in the canonical ensemble. The non-geometric integrator induces a drift in the invariant quantity, while our integrator has no such drift, thus ensuring that the system is effectively sampling the correct ensemble.

Geometric integrator for simulations in the canonical ensemble

International Nuclear Information System (INIS)

Tapias, Diego; Sanders, David P.; Bravetti, Alessandro

2016-01-01

We introduce a geometric integrator for molecular dynamics simulations of physical systems in the canonical ensemble that preserves the invariant distribution in equations arising from the density dynamics algorithm, with any possible type of thermostat. Our integrator thus constitutes a unified framework that allows the study and comparison of different thermostats and of their influence on the equilibrium and non-equilibrium (thermo-)dynamic properties of a system. To show the validity and the generality of the integrator, we implement it with a second-order, time-reversible method and apply it to the simulation of a Lennard-Jones system with three different thermostats, obtaining good conservation of the geometrical properties and recovering the expected thermodynamic results. Moreover, to show the advantage of our geometric integrator over a non-geometric one, we compare the results with those obtained by using the non-geometric Gear integrator, which is frequently used to perform simulations in the canonical ensemble. The non-geometric integrator induces a drift in the invariant quantity, while our integrator has no such drift, thus ensuring that the system is effectively sampling the correct ensemble.

Gossypol induces pyroptosis in mouse macrophages via a non-canonical inflammasome pathway

International Nuclear Information System (INIS)

Lin, Qiu-Ru; Li, Chen-Guang; Zha, Qing-Bing; Xu, Li-Hui; Pan, Hao; Zhao, Gao-Xiang; Ouyang, Dong-Yun; He, Xian-Hui

2016-01-01

Gossypol, a polyphenolic compound isolated from cottonseeds, has been reported to possess many pharmacological activities, but whether it can influence inflammasome activation remains unclear. In this study, we found that in mouse macrophages, gossypol induced cell death characterized by rapid membrane rupture and robust release of HMGB1 and pro-caspase-11 comparable to ATP treatment, suggesting an induction of pyroptotic cell death. Unlike ATP, gossypol induced much low levels of mature interleukin-1β (IL-1β) secretion from mouse peritoneal macrophages primed with LPS, although it caused pro-IL-1β release similar to that of ATP. Consistent with this, activated caspase-1 responsible for pro-IL-1β maturation was undetectable in gossypol-treated peritoneal macrophages. Besides, RAW 264.7 cells lacking ASC expression and caspase-1 activation also underwent pyroptotic cell death upon gossypol treatment. In further support of pyroptosis induction, both pan-caspase inhibitor and caspase-1 subfamily inhibitor, but not caspase-3 inhibitor, could sharply suppress gossypol-induced cell death. Other canonical pyroptotic inhibitors, including potassium chloride and N-acetyl-L-cysteine, could suppress ATP-induced pyroptosis but failed to inhibit or even enhanced gossypol-induced cell death, whereas nonspecific pore-formation inhibitor glycine could attenuate this process, suggesting involvement of a non-canonical pathway. Of note, gossypol treatment eliminated thioglycollate-induced macrophages in the peritoneal cavity with recruitment of other leukocytes. Moreover, gossypol administration markedly decreased the survival of mice in a bacterial sepsis model. Collectively, these results suggested that gossypol induced pyroptosis in mouse macrophages via a non-canonical inflammasome pathway, which raises a concern for its in vivo cytotoxicity to macrophages. - Highlights: • Gossypol induces pyroptosis in mouse peritoneal and RAW 264.7 macrophages. • In LPS

Gossypol induces pyroptosis in mouse macrophages via a non-canonical inflammasome pathway

Energy Technology Data Exchange (ETDEWEB)

Lin, Qiu-Ru; Li, Chen-Guang [Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632 (China); Zha, Qing-Bing [Department of Fetal Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510632 (China); Xu, Li-Hui [Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632 (China); Pan, Hao; Zhao, Gao-Xiang [Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632 (China); Ouyang, Dong-Yun, E-mail: dongyun1967@aliyun.com [Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632 (China); He, Xian-Hui, E-mail: thexh@jnu.edu.cn [Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632 (China)

2016-02-01

Gossypol, a polyphenolic compound isolated from cottonseeds, has been reported to possess many pharmacological activities, but whether it can influence inflammasome activation remains unclear. In this study, we found that in mouse macrophages, gossypol induced cell death characterized by rapid membrane rupture and robust release of HMGB1 and pro-caspase-11 comparable to ATP treatment, suggesting an induction of pyroptotic cell death. Unlike ATP, gossypol induced much low levels of mature interleukin-1β (IL-1β) secretion from mouse peritoneal macrophages primed with LPS, although it caused pro-IL-1β release similar to that of ATP. Consistent with this, activated caspase-1 responsible for pro-IL-1β maturation was undetectable in gossypol-treated peritoneal macrophages. Besides, RAW 264.7 cells lacking ASC expression and caspase-1 activation also underwent pyroptotic cell death upon gossypol treatment. In further support of pyroptosis induction, both pan-caspase inhibitor and caspase-1 subfamily inhibitor, but not caspase-3 inhibitor, could sharply suppress gossypol-induced cell death. Other canonical pyroptotic inhibitors, including potassium chloride and N-acetyl-L-cysteine, could suppress ATP-induced pyroptosis but failed to inhibit or even enhanced gossypol-induced cell death, whereas nonspecific pore-formation inhibitor glycine could attenuate this process, suggesting involvement of a non-canonical pathway. Of note, gossypol treatment eliminated thioglycollate-induced macrophages in the peritoneal cavity with recruitment of other leukocytes. Moreover, gossypol administration markedly decreased the survival of mice in a bacterial sepsis model. Collectively, these results suggested that gossypol induced pyroptosis in mouse macrophages via a non-canonical inflammasome pathway, which raises a concern for its in vivo cytotoxicity to macrophages. - Highlights: • Gossypol induces pyroptosis in mouse peritoneal and RAW 264.7 macrophages. • In LPS

Parameter Optimization for Selected Correlation Analysis of Intracranial Pathophysiology

Directory of Open Access Journals (Sweden)

Rupert Faltermeier

2015-01-01

Full Text Available Recently we proposed a mathematical tool set, called selected correlation analysis, that reliably detects positive and negative correlations between arterial blood pressure (ABP and intracranial pressure (ICP. Such correlations are associated with severe impairment of the cerebral autoregulation and intracranial compliance, as predicted by a mathematical model. The time resolved selected correlation analysis is based on a windowing technique combined with Fourier-based coherence calculations and therefore depends on several parameters. For real time application of this method at an ICU it is inevitable to adjust this mathematical tool for high sensitivity and distinct reliability. In this study, we will introduce a method to optimize the parameters of the selected correlation analysis by correlating an index, called selected correlation positive (SCP, with the outcome of the patients represented by the Glasgow Outcome Scale (GOS. For that purpose, the data of twenty-five patients were used to calculate the SCP value for each patient and multitude of feasible parameter sets of the selected correlation analysis. It could be shown that an optimized set of parameters is able to improve the sensitivity of the method by a factor greater than four in comparison to our first analyses.

Parameter Optimization for Selected Correlation Analysis of Intracranial Pathophysiology.

Science.gov (United States)

Faltermeier, Rupert; Proescholdt, Martin A; Bele, Sylvia; Brawanski, Alexander

2015-01-01

Recently we proposed a mathematical tool set, called selected correlation analysis, that reliably detects positive and negative correlations between arterial blood pressure (ABP) and intracranial pressure (ICP). Such correlations are associated with severe impairment of the cerebral autoregulation and intracranial compliance, as predicted by a mathematical model. The time resolved selected correlation analysis is based on a windowing technique combined with Fourier-based coherence calculations and therefore depends on several parameters. For real time application of this method at an ICU it is inevitable to adjust this mathematical tool for high sensitivity and distinct reliability. In this study, we will introduce a method to optimize the parameters of the selected correlation analysis by correlating an index, called selected correlation positive (SCP), with the outcome of the patients represented by the Glasgow Outcome Scale (GOS). For that purpose, the data of twenty-five patients were used to calculate the SCP value for each patient and multitude of feasible parameter sets of the selected correlation analysis. It could be shown that an optimized set of parameters is able to improve the sensitivity of the method by a factor greater than four in comparison to our first analyses.

Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

Energy Technology Data Exchange (ETDEWEB)

Kim, Byeong-Moo [Department of Medicine/GI Unit, Massachusetts General Hospital, Boston, MA 02114 (United States); Department of Medicine, Harvard Medical School, Boston, MA 02115 (United States); Choi, Michael Y., E-mail: mchoi@partners.org [Department of Medicine/GI Unit, Massachusetts General Hospital, Boston, MA 02114 (United States); Department of Medicine, Harvard Medical School, Boston, MA 02115 (United States); Harvard Stem Cell Institute, Boston, MA 02114 (United States)

2012-09-21

Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

Cerebrovascular endothelin-1 hyper-reactivity is associated with transient receptor potential canonical channels 1 and 6 activation and delayed cerebral hypoperfusion after forebrain ischaemia in rats

DEFF Research Database (Denmark)

Johansson, S E; Andersen, X E D R; Hansen, R H

2015-01-01

. METHODS: Experimental forebrain ischaemia was induced in Wistar male rats by a two-vessel occlusion model, and the cerebral blood flow was measured by magnetic resonance imaging two days after reperfusion. In vitro vasoreactivity studies, immunofluorescence and quantitative PCR were performed on cerebral...... in the vascular smooth muscle cells was enhanced and correlated with decreased cerebral blood flow two days after forebrain ischaemia. Furthermore, under conditions when voltage-dependent calcium channels were inhibited, endothelin-1-induced cerebrovascular contraction was enhanced and this enhancement...... was presumably mediated by Ca(2+) influx via upregulated transient receptor potential canonical channels 1 and 6. CONCLUSIONS: Our data demonstrates that endothelin-1-mediated influx of extracellular Ca(2+) activates transient receptor potential canonical channels 1 and 6 in cerebral vascular smooth muscle cells...

A Static Model of Abiotic Predictors and Forest Ecosystem Receptor Designed Using Dimensionality Reduction and Regression Analysis

Czech Academy of Sciences Publication Activity Database

Samec, P.; Rychtecká, P.; Tuček, P.; Bojko, J.; Zapletal, Miloš; Cudlín, Pavel

2016-01-01

Roč. 22, č. 2 (2016), s. 259-274 ISSN 1392-1355 R&D Projects: GA MŠk(CZ) LO1415 Institutional support: RVO:67179843 Keywords : forest state monitoring * EMEP-LRTAP * floodplain * mountain forests * canonical correlation analysis Subject RIV: EH - Ecology, Behaviour Impact factor: 0.635, year: 2016

On a Canonical Quantization of 3D Anti de Sitter Pure Gravity

CERN Document Server

Kim, Jihun

2015-10-14

We perform a canonical quantization of pure gravity on AdS3 using as a technical tool its equivalence at the classical level with a Chern-Simons theory with gauge group SL(2,R)xSL(2,R). We first quantize the theory canonically on an asymptotically AdS space --which is topologically the real line times a Riemann surface with one connected boundary. Using the "constrain first" approach we reduce canonical quantization to quantization of orbits of the Virasoro group and Kaehler quantization of Teichmuller space. After explicitly computing the Kaehler form for the torus with one boundary component and after extending that result to higher genus, we recover known results, such as that wave functions of SL(2,R) Chern-Simons theory are conformal blocks. We find new restrictions on the Hilbert space of pure gravity by imposing invariance under large diffeomorphisms and normalizability of the wave function. The Hilbert space of pure gravity is shown to be the target space of Conformal Field Theories with continuous sp...

Detrended cross-correlation analysis of electroencephalogram

International Nuclear Information System (INIS)

Wang Jun; Zhao Da-Qing

2012-01-01

In the paper we use detrended cross-correlation analysis (DCCA) to study the electroencephalograms of healthy young subjects and healthy old subjects. It is found that the cross-correlation between different leads of a healthy young subject is larger than that of a healthy old subject. It was shown that the cross-correlation relationship decreases with the aging process and the phenomenon can help to diagnose whether the subject's brain function is healthy or not. (interdisciplinary physics and related areas of science and technology)

Some reference formulas for the generating functions of canonical transformations

Energy Technology Data Exchange (ETDEWEB)

Anselmi, Damiano [Universita di Pisa, Dipartimento di Fisica ' ' Enrico Fermi' ' , Pisa (Italy); INFN, Sezione di Pisa, Pisa (Italy)

2016-02-15

We study some properties of the canonical transformations in classical mechanics and quantum field theory and give a number of practical formulas concerning their generating functions. First, we give a diagrammatic formula for the perturbative expansion of the composition law around the identity map. Then we propose a standard way to express the generating function of a canonical transformation by means of a certain ''componential'' map, which obeys the Baker-Campbell-Hausdorff formula. We derive the diagrammatic interpretation of the componential map, work out its relation with the solution of the Hamilton-Jacobi equation and derive its time-ordered version. Finally, we generalize the results to the Batalin-Vilkovisky formalism, where the conjugate variables may have both bosonic and fermionic statistics, and describe applications to quantum field theory. (orig.)

Generalized operator canonical formalism and gauge invariance

International Nuclear Information System (INIS)

Fradkina, T.E.

1988-01-01

A direct proof is given in the functional representation of the invariance of the S-matrix constructed in the framework of the generalized operator canonical formalism. We find the traditional functional expression for the S-matrix (without point-splitting in the time factor) in the generalized phase space, as well as in the ghost configuration space. An explicit expression is obtained for the effective unitarizing Hamiltonian for gauge theories with constraints of arbitrary rank

On the 'near to minimal' canonical realizations of the Lie algebra Csub(n)

International Nuclear Information System (INIS)

Havlicek, M.; Lassner, W.

1975-01-01

It is proved that canonical realizations of the Lie algebra Csub(n) in the quotient division ring Dsub(2(2n-2)) of the Weyl algebra Wsub(2(2n-2)) in 2n-2 quantum canonical pairs are, in a definite sense, related to the standard minimal one in Dsub(2n) contains Dsub(2(2n-2)). Further, in any realization of Csub(n) in Wsub(2(2n-1)) all Casimir operators are realized by multiples of identity element

Cable Connected Spinning Spacecraft, 1. the Canonical Equations, 2. Urban Mass Transportation, 3

Science.gov (United States)

Sitchin, A.

1972-01-01

Work on the dynamics of cable-connected spinning spacecraft was completed by formulating the equations of motion by both the canonical equations and Lagrange's equations and programming them for numerical solution on a digital computer. These energy-based formulations will permit future addition of the effect of cable mass. Comparative runs indicate that the canonical formulation requires less computer time. Available literature on urban mass transportation was surveyed. Areas of the private rapid transit concept of urban transportation are also studied.

Beyond or Below the Horizon? Sublime and Subliminal Challenges in Stewarding the Literary Canon

DEFF Research Database (Denmark)

Børch, Marianne

2015-01-01

The chapter discusses how certain texts may be excluded from canonical status by forms of resistance traceable to scholars' anxiety. Examples of such exiety are the 'fear of faith' and the 'fear of the literal.'......The chapter discusses how certain texts may be excluded from canonical status by forms of resistance traceable to scholars' anxiety. Examples of such exiety are the 'fear of faith' and the 'fear of the literal.'...

A note on T-duality, open strings in B-field background and canonical transformations

International Nuclear Information System (INIS)

Sheikh-Jabbari, M.M.

1999-11-01

In this paper we study T-duality for open strings ending on branes with non-zero B-field on them from the point of view of canonical transformations. For the particular case of type II strings on the two torus we show that the Sl(2, Z) N transformations can be understood as a sub-class of canonical transformations on the open strings in the B-field background. (author)

Non-Canonical Roles of Dengue Virus Non-Structural Proteins

Directory of Open Access Journals (Sweden)

Julianna D. Zeidler

2017-03-01

Full Text Available The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among members of a same family, but others being unique for each virus species. These non-canonical functions probably have evolved independently and may serve as the base to the development of specific therapies for each of those diseases. Here it is discussed what is currently known about the non-canonical roles of dengue virus (DENV non-structural proteins (NSPs, which may account for some of the effects specifically observed in DENV infection, but not in other members of the Flaviviridae family. This review explores how DENV NSPs contributes to the physiopathology of dengue, evasion from host immunity, metabolic changes, and redistribution of cellular components during infection.

Method of collective variables with reference system for the grand canonical ensemble

International Nuclear Information System (INIS)

Yukhnovskii, I.R.

1989-01-01

A method of collective variables with special reference system for the grand canonical ensemble is presented. An explicit form is obtained for the basis sixth-degree measure density needed to describe the liquid-gas phase transition. Here the author presents the fundamentals of the method, which are as follows: (1) the functional form for the partition function in the grand canonical ensemble; (2) derivation of thermodynamic relations for the coefficients of the Jacobian; (3) transition to the problem on an adequate lattice; and (4) obtaining of the explicit form for the functional of the partition function

[Electroencephalogram Feature Selection Based on Correlation Coefficient Analysis].

Science.gov (United States)

Zhou, Jinzhi; Tang, Xiaofang

2015-08-01

In order to improve the accuracy of classification with small amount of motor imagery training data on the development of brain-computer interface (BCD systems, we proposed an analyzing method to automatically select the characteristic parameters based on correlation coefficient analysis. Throughout the five sample data of dataset IV a from 2005 BCI Competition, we utilized short-time Fourier transform (STFT) and correlation coefficient calculation to reduce the number of primitive electroencephalogram dimension, then introduced feature extraction based on common spatial pattern (CSP) and classified by linear discriminant analysis (LDA). Simulation results showed that the average rate of classification accuracy could be improved by using correlation coefficient feature selection method than those without using this algorithm. Comparing with support vector machine (SVM) optimization features algorithm, the correlation coefficient analysis can lead better selection parameters to improve the accuracy of classification.

Semi-Supervised Multi-View Ensemble Learning Based On Extracting Cross-View Correlation

Directory of Open Access Journals (Sweden)

ZALL, R.

2016-05-01

Full Text Available Correlated information between different views incorporate useful for learning in multi view data. Canonical correlation analysis (CCA plays important role to extract these information. However, CCA only extracts the correlated information between paired data and cannot preserve correlated information between within-class samples. In this paper, we propose a two-view semi-supervised learning method called semi-supervised random correlation ensemble base on spectral clustering (SS_RCE. SS_RCE uses a multi-view method based on spectral clustering which takes advantage of discriminative information in multiple views to estimate labeling information of unlabeled samples. In order to enhance discriminative power of CCA features, we incorporate the labeling information of both unlabeled and labeled samples into CCA. Then, we use random correlation between within-class samples from cross view to extract diverse correlated features for training component classifiers. Furthermore, we extend a general model namely SSMV_RCE to construct ensemble method to tackle semi-supervised learning in the presence of multiple views. Finally, we compare the proposed methods with existing multi-view feature extraction methods using multi-view semi-supervised ensembles. Experimental results on various multi-view data sets are presented to demonstrate the effectiveness of the proposed methods.

Canonical action-angle formalism for quantized nonlinear fields

International Nuclear Information System (INIS)

Garbaczewki, P.

1987-01-01

The canonical quantizations of field and action-angle coordinates which (locally) parameterize the phase manifold for the same nonlinear field theory model (e.g. sine-Gordon and nonlinear Schrodinger with the attractive coupling) are reconciled on the common for both cases state space. The classical-quantum relationship is maintained in the mean: coherent state expectation values of operators give rise to classical objects

Psychological career meta-capacities in relation to employees ...

African Journals Online (AJOL)

A canonical correlation analysis indicated a significant overall relationship between the psychological career meta-capacities and the retention- related dispositions. Structural equation modelling indicated a good fit of the data with the canonical correlation-derived measurement model. In the employment equity context, the ...

New integral representations of the Maslov canonical operator in singular charts

Science.gov (United States)

Dobrokhotov, S. Yu.; Nazaikinskii, V. E.; Shafarevich, A. I.

2017-04-01

We construct a new integral representation of the Maslov canonical operator convenient in numerical-analytical calculations, present an algorithm implementing this representation, and consider a number of examples.

Paintings beyond the Boundaries of the Canon: Bulgarian Churches and Monasteries XVII - XIX Century

Directory of Open Access Journals (Sweden)

P. Sabev

2015-09-01

Full Text Available Traditions in the decoration of Christian temples on the Balkans are largely related to strictly established rules, deriving from Byzantium and developed in the theological ranges in the empire. The holy fathers like John of Damascus and Theodore the Studite announced themselves in defense of veneration of the icons (overcoming the crisis of persecution, something more – their theological insights and logically consistent studies give the possibility to artists to express their feelings and conceptions but taking into consideration the ecclesiastical rules – canons. The article explores process of breaking the boundaries of canon set by Church Fathers as a result of unpreparedness, ignorance and total aesthetic decline after Ottoman invasion. It is appeared various levels of naive art and breaking of the canon established by the Orthodox Church. Many examples passing beyond the boundaries of ecclesiastical rules are presented.

Second-moment sum rules for correlation functions in a classical ionic mixture