An infographic from the National Cancer Institute (NCI) describing the four broad categories of cancer research: basic research, clinical research, population-based research, and translational research.
This book offers a lively introduction to the research methods and techniques available to English language teachers who wish to investigate aspects of their own practice. It covers qualitative and quantitative methodology and includes sections on observation, introspection, diary studies, experiments, interviews, questionnaires, numerical techniques and case study research. Each method is illustrated with examples in language teaching contexts, and techniques of data collection and analysis are introduced. The authors focus particularly on research in the classroom, on tests, materials, the
Full Text Available Business English is integrated with visual-audio-oral English, which focuses on the application for English listening and speaking skills in common business occasions, and acquire business knowledge and improve skills through English. This paper analyzes the Business English Visual-audio-oral Course, and learning situation of higher vocational students’ learning objectives, interests, vocabulary, listening and speaking, and focuses on the research of effective methods to guide the higher vocational students to learn Business English Visual-audio-oral Course, master Business English knowledge, and improve communicative competence of Business English.
As a reflective approach to teacher development,Action Research (AR)is gaining significance in education and is especially credited as providing an opportunity for professionals including both teachers and teacher educators to investigate their own classroom practice and improve it,and hopefully bring favorable changes to their classrooms.It emphasizes the role of critical reflection and always involves a problem→hypothesis→resolution cycle or spiral during which teacher researchers exert efforts to explore teaching and learning.By doing action research,language teachers can not only apply theories into practice but also be more reflective,more critical and more open to change in teach-ing approaches and methods.Despite the difficulties that teachers may have in doing action research in their busy life,it is beneficial for teach-ers to be researchers in the long run.
English writing is also a crucial means of evaluating the language proficiency of a learner of English as second language. As a result, it is essential to review English writing researching in terms of contents, number, methods, process, feedback and as⁃sessment which can guide our English writing teaching effectively.
With the increasing importance attached to spoken English, it is of great significance to find how the motivation of English majors affects their oral English learning outcomes. Based on the research results and theoretical frameworks of the previous studies on this area, this paper carries out research in Zhujiang College of South China Agricultural University trying to find out the types of motivation and the correlation between motivation factors of English majors and their spoken English, and thus to guide spoken English learning and teaching.
Plo Alastrué, Ramón
This volume examines the role of English in academic and research settings in Europe and provides recommendations on the challenges posed by the dominance of English over national languages as languages of science and research dissemination; the need for language support for academics that need to disseminate their research in English; and the effect of past and present language policies.
Business English is integrated with visual-audio-oral English, which focuses on the application for English listening and speaking skills in common business occasions, and acquire business knowledge and improve skills through English. This paper analyzes the Business English Visual-audio-oral Course, and learning situation of higher vocational students’ learning objectives, interests, vocabulary, listening and speaking, and focuses on the research of effective methods to guide the higher voca...
<正>This thesis discusses the relations among English learning motivations, learning strategies and study efficiency under China’s background through reviewing the Chinese and overseas English learning motivation research, analyzing its explanation, characteristics and the questionnaire results. Several suggestions on how to stimulate and foster the students’English learning motivation have been given through the analysis of existing problems in the English study of students. I expect these would be animating English teaching in school.
The investigators in the cell biology program at PCRI have pioneered in the development of techniques for culturing human epithelial cells. The cancer diagnosis program has been concerned with researching new techniques for early diagnosis of breast cancer in women. The cancer treatment program has been concerned with applying cell biology and biochemistry advances to improve cancer management
OBJECTIVES: English has become the most frequently used language for scientific communication in the biomedical field. Therefore, scholars from all over the world try to publish their findings in English. This trend has a number of advantages, along with several disadvantages. METHODS: In the current article, the most important disadvantages of publishing biomedical research articles in English for non-native speakers of English are reviewed. RESULTS: The most important disadvantages of publi...
Xuesong Gao; Alice Wai Kwan Chow
Research engagement is an important means for teachers to develop their professional competence. This paper reports on an enquiry into the research engagement of a group of primary school English language teachers in Guangdong province on the Chinese mainland. Drawing on questionnaire data and teachers' interview narratives, the paper examines how these Chinese primary school teachers experienced research and what their conceptions of good quality research were. While the enquiry revealed that the participants had a variety of research experiences, it also revealed that their
Full Text Available Our paper analyzed relevant acoustic parameters of people’s speech samples and the results that compared with English standard pronunciation with methods of experimental phonetics by phonetic analysis software and statistical analysis software. Then we summarized phonetic pronunciation errors of college students through the analysis of English pronunciation of vowels, we found that college students’ English pronunciation are easy occur tongue position and lip shape errors during pronounce vowels. Based on analysis of pronunciation errors, we put forward targeted voice training for college students’ English pronunciation, eventually increased the students learning interest, and improved the teaching of English phonetics.
Ni Ketut Mirahayuni
Full Text Available Abstract. Research into English research articles (RAs has largely been focused on articles produced by native English writers. This paper reports a study aiming to investigate the textual structure of research articles written by non-native English (i.e. Indonesian writers, which may contribute to their acceptance for international publication. A comparison is made between RAs written by native English speakers, an Indonesian writers writing in English, all in the field of Language and Language Teaching. It explores the relation of text's generic structure. The thesis develops a framework for the generic structure analysis based on Swales' (1990 Create-AÂResearch-Space (CARS model of moves. The analysis focuses on two RA sections: Introduction and Discussion. The findings indicate significant differences in both forms and functions of organizing strategics between the native and non-native texts. The differences may partly be due to the influence of writing practices in the non-native writers' first language and partly to the writer's attempt to find an appropriate format in the absence of well-established research writing conventions in the first language. Consequently, non-native English texts may show organizing strategies unfamiliar to both the native English and native Indonesian texts. Findings from the research highlight two issues. First, formal and functional differences of generic structure elements and their realizations between the native and non-native English texts may disadvantage the non-native writers, particularly with regards to employment of unfamiliar organizational
Ni Ketut Mirahayuni
Full Text Available Research into English research articles (RAs has largely been focused on articles produced by native English writers. This paper reports a study aiming to investigate the textual structure of research articles written by non-native English (i.e. Indonesian writers, which may contribute to their acceptance for international publication. A comparison is made between RAs written by native English speakers, an Indonesian writers writing in English, all in the field of Language and Language Teaching. It explores the relation of text's generic structure. The thesis develops a framework for the generic structure analysis based on Swales' (1990 Create-A-Research-Space (CARS model of moves. The analysis focuses on two RA sections: Introduction and Discussion. The findings indicate significant differences in both forms and functions of organizing strategies between the native and non-native texts. The differences may partly be due to the influence of writing practices in the non-native writers' first language and partly to the writer's attempt to find an appropriate format in the absence of well-established research writing conventions in the first language. Consequently, non-native English texts may show organizing strategies unfamiliar to both the native English and native Indonesian texts. Findings from the research highlight two issues. First, formal and functional differences of generic structure elements and their realizations between the native and non-native English texts may disadvantage the non-native writers, particularly with regards to employment of unfamiliar organizational strategies. Second, non-native English writers need to acquire knowledge of commonly used formal generic structure, and more importantly, the knowledge of the nature of scientific writing in English to be able to gain wider readership. The implications for further research and the teaching of academic writing are discussed.
These articles put a face to some of the thousands of individuals who contribute to NCI’s cancer research efforts. The profiles highlight the work of scientists and clinicians and describe the circumstances and motivation behind their work.
This paper considers the problems, the properties, and the prospects of using "English as a lingua franca" as a construct and as a reality. It will therefore focus on what is meant by the term "lingua franca", what is represented as a "lingua franca", and what the debates are about English as a lingua franca. The point of departure is Kachru's…
Abel, Gary A; Saunders, Catherine L; Lyratzopoulos, Georgios
BACKGROUND: Surveys of the experience of cancer patients are increasingly being introduced in different countries and used in cancer epidemiology research. We examine how sampling processes, post-sampling mortality and survey non-response influence the representativeness of cancer patient surveys. METHODS: We examined predictors of post-sampling mortality and non-response among patients initially included in the sampling frame of the English Cancer Patient Experience Survey. We also comp...
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This paper compares the rhetorical organization of research article introductions in Brazilian Portuguese and in English within a subfield of Applied Linguistics. Using Swales' (1990) CARS model as an analytical tool, this exploratory study investigated 20 research articles. The findings indicate that introductions in Brazilian Portuguese tend to…
Yina SHEN; Du, Hui; Shen, Juan
To solve the problem existing in Chinese culture English websites, which is focusing on “introduction” while ignoring “communication”, based on the concept and core applications of virtual community, a planning research on Chinese culture English virtual community is described in this paper, which includes general requirement analysis, general structure planning and application platform planning. The aim is to provide a more comprehensive internet platform for foreigners to learn Chi...
On April, 22-24 April 1991, the Hungarian National Institute of Oncology and the Commission of the European Communities have organized a workshop on Cancer Research. The aim of the meeting was to provide the participants information on the ongoing research in Hungary and in Member States. The topic is of importance for Hungary and it was also considered that the meeting could contribute to identify subjects of possible collaboration between Hungarian and Member State laboratories in the case financial support would become available. Three papers about new therapies under development were presented proton therapy and Boron neutron capture therapy
Investigates differences in the rhetorical organization of research article introductions between Korean academic writing and English academic writing based on Swales' Create a Research Space model (1990). Twelve published articles written by Korean national scholars and American scholars are compared, and eight term papers by Korean…
Sanjaya, I Nyoman Suka
The present cross-cultural and cross-disciplinary study was aimed at exploring the similarities and differences between English and Indonesian research articles from the disciplines of applied linguistics and chemistry in terms of frequency of usage of hedges (e.g. "perhaps," "may") and boosters (e.g. "clearly,"…
Chen, Suchiao; Tsai, Yachin
This article analyzes research in second/foreign language teaching and learning conducted in Taiwan over the period 2004-2009. Representative articles published in local refereed journals and conference proceedings--not readily accessible outside Taiwan--are reviewed to reflect current trends in English teaching and learning. The main themes…
Nordic Documentation Center for Mass Communication Research, Aarhus (Denmark).
This update to the bibliographies from Nordicom edited in 1975 and 1976 lists publications on mass communications research from Denmark, Finland, and Norway, that have appeared in one or more of the three languages--English, French, or German. Materials are listed for each country separately, arranged by author (or title if there is no author),…
Belcher, Diane D.
Many have noted the increasing concentration of gatekeeping power in the hands of mainstream English-only journals and made compelling cases for the need to bring more off-networked, multilingual voices into the global research conversation. Despite the hurdles that often face under-resourced off-network scholars, a number of them do find their…
Full Text Available The present paper explores biomedical research coverage in the Indian English-language newspapers. Science and technology coverage in the Indian English-language newspapers revealed dominant representation of biomedical research. The research reported was mainly from foreign sources, mostly performed in US, UK and other developed countries of Europe. Plausibly, this was the major reason that areas of medical concerns in foreign countries such as Neuroscience, Oncology, Genetics and Cardiovascular research constituted more than one-third of the total space whereas neglected tropical diseases have almost been neglected in the coverage. This is despite the fact that tropical and other neglected diseases constitute the greatest health problem in India. The study discusses the significance of this research for policy planners, media, health information dissemination and those concerned about informed and science literate citizenry in the country.
Names are unique phenomenon in human society. People from different countries all have their only names, which generally consist of the first name and the last name. Not only in reality, but also in literary works, they all have their unique names, but the naming methods and intention are different. This paper emphasizes the naming methods and intention in English novels. The names of English novels usually have a richer culture, it embodies the character traits and characters in the novel, such as the outcome of their fate. Therefore, the research of the cultural intention of English novels and translating names accurately is of great significance for literary translation, which also plays an important role in the East-West cultural exchange.
Bauer, Bruno; Schmidt, Nora; Sánchez Solís, Barbara; Preza, José Luis; Mühlegger, Johannes Michael; Gumpenberger, Christian; Gründhammer, Veronika; Gorraiz, Juan; Ferus, Andreas
In 2015, this survey was directed at the scientific and artistic-scientific personnel of all 21 public universities and three extramural research institutions in Austria. The questionnaire is based on institutional, discipline-specific surveys that have already been performed at universities and research institutions in other countries. Emphasis was placed on the creation of a specially developed questionnaire which took into consideration the different cultures in science and art.
This article argues that Cultural Historical Activity Theory (CHAT) is an appropriate theoretical and methodological framework for researchers in English interested in the social contexts of culture and its relationship with the formation of mind and activity in the English classroom. Two key concepts in Vygotsky's thought central to understanding…
Høybye, Mette Terp; Dalton, Susanne Oksbjerg; Christensen, Jane;
cancer survivors with respect to cancer site, sociodemographic variables, social network, lifestyle, self-rated health and the prevalence of cancer-related late effects. The study is part of the FOCARE research project, in which the long-term effects of the rehabilitation programme are evaluated...... rate at baseline was 86% (n = 1876). Most participants were younger women with breast cancer. They were generally well educated and working. The cancer survivors reported having comprehensive social networks and being physically active. Several cancer-related symptoms were reported by women with...... site, sex, age, family, working status and social position. These challenges might be addressed optimally in multi-dimensional rehabilitation programmes....
Loi, Chek Kim
This study investigates the rhetorical organisation of English and Chinese research article introductions in the field of educational psychology using (Swales, 1990) and (Swales, 2004) framework of move analysis. A corpus of 40 research articles (20 Chinese and 20 English) was selected. The English research articles, written by first-language…
"English: An Essential Grammar" is a concise and user-friendly guide to the grammar of modern English, written specifically for native speakers and based on genuine samples of contemporary spoken and written English. In four chapters, the book covers the essentials of English grammar, beginning with the basics and going on to deal with phrase, clause and sentence structure. A fifth chapter deals with English word formation and spelling, including problem spellings and British and American spelling variants. Features of this title include: discussion of points that often cause problem
The course is the core of education, which is the basic way to achieve educational goals, an educational content and value orientation are mainly expressed and implemented through the curriculum. English courses are the core of English education, which is a concrete manifestation of the value of English education, and it is basic carrier to achieve the goal of English education. This paper analyzes the development of English teaching practice, development and reform of English teaching methods.
Wang Weijia; Zhang Rupeng; Liang Han; Zhang Hui; Li Fangxuan; Yu Jinpu; Li Hui
Objective To introduce the recent developments in cancer immunoinformatics with an emphasis on the latest trends and future direction.Data sources All related articles in this review were searched from PubMed published in English from 1992 to 2013.The search terms were cancer,immunoinformatics,immunological databases,and computational vaccinology.Study selection Original articles and reviews those were related to application of cancer immunoinformatics about tumor basic and clinical research were selected.Results Cancer immunoinformatics has been widely researched and applied in a series of fields of cancer research,including computational tools for cancer,cancer immunological databases,computational vaccinology,and cancer diagnostic workflows.Furthermore,the improvement of its theory and technology brings an enlightening insight into understanding and researching cancer and helps expound more deep and complete mechanisms of tumorigenesis and progression.Conclusion Cancer immunoinformatics provides promising methods and novel strategies for the discovery and development of tumor basic and clinical research.
Cameron, Carrie; Chang, Shine; Pagel, Walter
Within the international research environment, English is indisputably the lingua franca, and thus, the majority of the world's scientists must adapt to a second language. Linguistic barriers in science affect not only researchers' career paths but institutional productivity and efficiency as well. To address these barriers, we designed and piloted a specialized course, Scientific English. The pedagogical approach is based on English for specific purposes methodology in which curriculum and content are driven by the types of daily language used and interactions which occur in the participants' occupation, in this case, cancer research. The 11-week program was organized into three sections: presentation skill, meeting and discussion skills, and writing skills. Effectiveness of the course was measured by the number of participants able to produce the presentations and written products with a score of at least 75 of 100 possible points. From January to December 2008, participant scores averaged 90.4 for presentation and 86.8 for written products. The authors provide insights and recommendations on the development and delivery of the program. PMID:20623348
Wei Zhang; Lynette Moore; Ping Ji
Mouse models of cancer enable researchers to leamn about tumor biology in complicated and dynamic physiological systems. Since the development of gene targeting in mice, cancer biologists have been among the most frequent users of transgenic mouse models, which have dramatically increased knowledge about how cancers form and grow. The Chinese Joumnal of Cancer will publish a series of papers reporting the use of mouse models in studying genetic events in cancer cases. This editorial is an overview of the development and applications of mouse models of cancer and directs the reader to upcoming papers describing the use of these models to be published in coming issues, beginning with three articles in the current issue.
... of pancreatic cancer Researchers identify early sign of pancreatic cancer September 28, 2014 Tags: PancreaticCancer Brian Wolpin, MD ... discovered a sign of the early development of pancreatic cancer – an upsurge in certain amino acids that occurs ...
Geng, Ruihui; Li, Zhaoshen; Li, Shude; Gao, Jun
Pancreatic cancer is a highly aggressive malignancy with a poor prognosis and deeply affects the life of people. Therefore, the earlier diagnosis and better treatments are urgently needed. In recent years, the proteomic technologies are well established and growing rapidly and have been widely applied in clinical applications, especially in pancreatic cancer research. In this paper, we attempt to discuss the development of current proteomic technologies and the application of proteomics to the field of pancreatic cancer research. This will explore the potential perspective in revealing pathogenesis, making the diagnosis earlier and treatment. PMID:22084685
Full Text Available Concern expressed by government and other funding agencies and consumers of research, about the quality and relevance of research in the field of education affects not only the kind of research is conducted but also the way in which we educate researchers. The economic imperative for ‘value for money’ from research and researchers has, for instance, led to the education of research students to be seen increasingly in terms of training in a range of generic skills that can be applied to the investigation of a range of forms of research problem in a variety of contexts. Whilst breadth in the education of researchers has clear advantages, both for the careers of individual researchers and the wider research community, there is some tension between this approach and the more established view of a research degree as an induction into a narrow domain of knowledge and the production of a highly specialised academic identity. There are further developments that erode this notion of specialisation, for instance the growth of mixed method research, which has the potential to challenge the polarisation of qualitative and quantitative research, and shifts in the sites and agents of educational research signified by the growth of professional doctorates, which could further challenge the university as a dominant institution in the production of educational knowledge. In this paper I will explore what these developments mean for the teaching of research and consider how we can work collaboratively to develop both professional researchers and researching professionals, and reconcile the acquisition of skills with induction into specialised knowledge domains. This will involve exploration of both an overarching framework for thinking about the processes of doing research and specific examples of practice. Underlying the approach taken is a general commitment to research education, rather than to training and the teaching of methods, and the desire to ensure
College English teaching compares with the traditional English teaching from visual-audio-oral aspects. The integrated English teaching is mainly manifested in the target, systematicness, normalization, efficiency and effectiveness of the integrated English teaching quality. With the criteria of practicability, quality, integration and language features of the integrated teaching, this paper carries out quantifiable weight analysis of the integrated college English teaching content based on A...
By employing quantitative research methods, the paper investigates college students ’preferences to English classroom behaviors and the relations between behaviors and achievements. The results indicate that there are significant differences among the subjects’behavior, cognitive and emotional elements, and their classroom behaviors are mainly visual, individual, imitative and exterior-motivated;there are significant differences in behavior element and emotional element between high-result group and low-result group;confident and oral classroom behaviors have prominent relations with CET-4 achievements, and different teaching methods may make learning behaviors produce good or bad effects to achievements.
Nan Zhao; Ruixian Ma; Xiaomei Du
This thesis aims at analyzing the American English translation of Chinese signs in Baoding from the perspective of cultural differences. The thesis researches on signs translation from a new angle by separating American English translation from British English translation and puts special emphasis on American English signs translation, which may be helpful to the standardization of signs translation in China. Through digging out the cultural differences from different thinking mode, value, an...
The article exemplifies and presents the characteristics of linguistic imperialism, linguistic capital accumulation following the same pattern as capitalist economic dominance. The text summarizes the way English was established in the colonial period. Many of the mechanisms of linguistic hierarchy...... have been maintained and intensified since then, as African and Indian scholarship demonstrates. Language plays a key role in education, the World Bank taking over where colonial regimes left off. Anglo-American efforts to maintain global English dominance have intensified since 1945 and are central to...... the present-day world ‘order’, as the postcolonial is subsumed under global empire, assisted by English linguistic neoimperialism. Some scholars who deny the existence of linguistic imperialism are reported on, and the complexity of language policy in European integration is demonstrated. The article...
... Research AMIGAS Fighting Cervical Cancer Worldwide Stay Informed Statistics for Other Kinds of Cancer Breast Cervical Colorectal ( ... Skin Vaginal and Vulvar Cancer Home Uterine Cancer Statistics Language: English Español (Spanish) Recommend on Facebook Tweet ...
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Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue. Outgrowth of cells from duct element in upper right corner cultured in a standard dish; most cells spontaneously die during early cell divisions, but a few will establish long-term growth. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Tichmond, NASA/Marshall Space Flight Center (MSFC).
Full Text Available In recent years, with the continuous improvement of English teaching way, the interaction and communication way in English teaching has become an important means to improve English teaching. This paper illustrates the benefits of interaction and communication in English teaching, and introduces three interaction and communication ways in English teaching - unilateral communication between teachers and students, multi-directional communication between teachers and students, and multi-level communication between teachers and students, and carries out experimental teaching based on these three ways. This paper uses the factor analysis to analyze the student performance in listening, speaking, reading and writing, and determines the proportion of performance in these four aspects according to the analysis results. This paper evaluates the effect of role of three interaction and communication ways in English teaching according to the fuzzy comprehensive evaluation. The results show that the unilateral communication between teachers and students is slightly superior.
César Eduardo Jiménez Calderón
The objective of the study is to elaborate a systemically logicpathway of technology research methodology for teachingEnglish to speakers of other languages based on the inferentialcognitive paradigm. The inferential process consists of passingfrom previous statements, considered as true outcomes, to otherones whose propositions arise from either the need of currentreal information or the consequence of former statements. If theproposal technology research pathway is followed by educativerese...
Moodie, Ian; Nam, Hyun-Jeong
This article reviews recent studies on English language teaching (ELT) in South Korea, where a great deal of research has been produced in recent years in local journals. In this article we review 95 studies from a pool of some 1,200 published between 2009 and 2014 on English language teaching and learning, focusing on research within the public…
Academic writing for research publication takes place around the globe, involving, according to a recent account, 5.5 million scholars, 2,000 publishers and 17,500 research/higher education institutions (Lillis & Curry 2010: 1). Because so many scholars whose first language is not English are now using English for publication purposes and…
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... Current Issue Past Issues Honoring Pioneers in Breast Cancer Research Past Issues / Spring 2007 Table of Contents For ... Distinguished Medical Service Award for their pioneering breast cancer research. Photo courtesy of Bill Branson, NIH In this ...
Federal Laboratory Consortium — Among the many cancer research laboratories operated by NCI, the Frederick National Laboratory for Cancer Research(FNLCR) is unique in that it is a Federally Funded...
The Epidemiology and Genomics Research Program supports extramural research that investigates both genetic and environmental factors that may contribute to the etiology of cancer and/or impact cancer outcomes.
Federal Laboratory Consortium — Research Area: Herbs Program:Centers of Excellence for Research on CAM Description:Colorectal cancer is the third most common cancer and the third leading cause of...
William C. S. Cho
Full Text Available Massive evidence suggests that genetic abnormalities contribute to the development of lung cancer. These molecular abnormalities may serve as diagnostic, prognostic and predictive biomarkers for this deadly disease. It is imperative to search these biomarkers in different tumorigenesis pathways so as to provide the most appropriate therapy for each individual patient with lung malignancy. Phosphoproteomics is a promising technology for the identification of biomarkers and novel therapeutic targets for cancer. Thousands of proteins interact via physical and chemical association. Moreover, some proteins can covalently modify other proteins post-translationally. These post-translational modifications ultimately give rise to the emergent functions of cells in sequence, space and time. Phosphoproteomics clinical researches imply the comprehensive analysis of the proteins that are expressed in cells or tissues and can be employed at different stages. In addition, understanding the functions of phosphorylated proteins requires the study of proteomes as linked systems rather than collections of individual protein molecules. In fact, proteomics approaches coupled with affinity chromatography strategies followed by mass spectrometry have been used to elucidate relevant biological questions. This article will discuss the relevant clues of post-translational modifications, phosphorylated proteins, and useful proteomics approaches to identify molecular cancer signatures. The recent progress in phosphoproteomics research in lung cancer will be also discussed.
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Alexios S Strimpakos
Full Text Available The high mortality rate of pancreatic cancer places this uncommon malignancy quite high as a cause of cancer related deaths. Compared to other solid tumors, there is a lag in the development of new effective drugs and the actual clinical benefit remains poor over the last decade or so. The lack of therapeutic options necessitates the invention of the important molecules playing role in pancreatic carcinogenesis and the development of specific targeted therapies. Treatment advances have to be proven first in the bench before applying them at the bedside, thus why translational research is so needed. At the 2011 American Society of Clinical Oncology (ASCO Gastrointestinal Cancers Symposium, preclinical evidence was presented regarding the efficacy of C4 compound against focal adhesion kinase (FAK (Abstract #214, the role of the cyclooxygenase-2 (COX-2 inhibitor apricoxib in enhancing the efficacy of gemcitabine and erlotinib (Abstract #227 and the role of curcumin and ABT-888 (a poly-ADP ribose polymerase (PARP inhibitor as potent radiosensitizers (Abstracts #222 and #203. Interestingly, the invention of a novel monoclonal antibody (ensituximab against the mucin epitope NPC-1C in pancreatic and colon cancer cell lines exhibited notable antibody-dependent cellular cytotoxicity (Abstract #235. Finally, enhanced selective targeting of pancreatic tumors was achieved by combining antibody-drug conjugates (ADC with radioimmunotherapy (Abstract #206.
I come to this article as an experienced primary and middle years teacher and midcareer university-based academic with a vested interest in researching the message systems of the disciplinary field of subject English. My sociocultural perspective challenges those who view English teaching predominantly as a cognitive act of learning to read or…
The paper presents a contrastive analysis focusing on the differences in the use of two selected metatext categories, previews and reviews, in English and Slovene research articles. The analysis is based on the hypothesis that the use of the selected metatext categories is more restricted in Slovene academic writing than in English academic…
Banegas, Dario; Pavese, Anahi; Velazquez, Aurelia; Velez, Sandra Maria
In 2011 we, a group of English-as-a-foreign-language teachers at a secondary school in Argentina, decided to investigate our teaching practices through collaborative action research so as to improve our students' learning opportunities and thus revitalise English-language teaching in our context. We implemented and evaluated the integration of…
A cross-cultural approach is taken to analyse Linguistics research articles in English and Italian in terms of 1) the use of exclusive first-person subject pronouns in English and first-person inflected verbs in Italian, and 2) the passive voice in both languages and "si" constructions in Italian. The aim is to determine whether personal and…
This article examines the role of agency for the English language development of three Chinese research students with high English proficiency sojourning in Australia. The focus is on the various approaches the learners employed to strengthen their sense of confidence in their language use in Australia. The data were obtained through in-depth…
This paper aims to resesrch on the autonmons tearning so as to improve the college students’English learning . First of all, it introdues some basic concepts of the autonomous learning theory , Secondly, it analyzes the current situation of college Eng⁃lish students’listening and speaking. In this passage the anthor hopes that it is helpful to improve college students’listening and speaking level by their autonomous learning. It is helpful to improve their listening and speaking ability. As a result, it is helpful to develop college students’English comprehensive application ability.
According to the characteristics of Business English Writing Course,this essay analyses the teaching status, then in the frame of communication theory, it puts forward a new teaching model-PIADA. It is proved that this new teaching model can explore the teacher’s subjective initiative, mobilize the enthusiasm of the students fully, make the teaching process more systemat-ic and scientific, and eventually greatly improve students' English writing ability.
With the continuous progress of the integration of information technology and English teaching course under the network environment, the traditional teaching mode cannot meet to listening teaching resources requirement, Web listening corpus is the main way to solve the problem. The paper design the small Web corpus for university English listening teaching development based on the introduction of Web corpus, and this corpus has realized to the listening material retrieval, browsing, online listening watch and update functions.
Shan-Cheng Ren; Rui Chen; Ying-Hao Sun
Prostate cancer (PCa) research in China has been on a rocketing trend in recent years.The first genome-wide association study (GWAS)in China identified two new PCa risk associated single nucleotide polymorphisms (SNPs).Next generation sequencing is beginning to be used,yielding novel findings:gene fusions,long non-coding RNAs and other variations.Mechanisms of PCa progression have been illustrated while various diagnosis biomarkers have been investigated extensively.Personalized therapy based on genetic factors,nano-medicine and traditional Chinese medicine has been the focus of experimental therapeutic research for PCa.This review intends to shed light upon the recent progress in PCa research in China and points out the possible breakthroughs in the future.
Jeffrey R. Harris, MD, MPH, MBA
Full Text Available The Cancer Prevention and Control Research Network is a national network recently established to focus on developing new interventions and disseminating and translating proven interventions into practice to reduce cancer burden and disparities, especially among minority and medically underserved populations. Jointly funded by the Centers for Disease Control and Prevention and the National Cancer Institute, the Cancer Prevention and Control Research Network consists of sites administered through Prevention Research Centers funded by the Centers for Disease Control and Prevention. The five sites are located in Kentucky, Massachusetts, South Carolina, Texas, Washington State, and West Virginia. The Cancer Prevention and Control Research Networks intervention areas include primary prevention of cancer through healthy eating, physical activity, sun avoidance, tobacco control, and early detection of cancer through screening. The Cancer Prevention and Control Research Network uses the methods of community-based participatory research and seeks to build on the cancer-relevant systematic reviews of the Guide to Community Preventive Services. Initial foci for the Cancer Prevention and Control Research Networks research work groups include projects to increase screening for breast, cervical, and colorectal cancers; to promote informed decision making for prostate cancer screening; and to validate educational materials developed for low-literacy populations.
... resources for eye cancer What’s new in eye cancer research and treatment? Many medical centers around the world ... Your Doctor After Treatment What`s New in Eye Cancer Research? Other Resources and References Cancer Information Cancer Basics ...
... salivary gland cancer What’s new in salivary gland cancer research and treatment? Medical centers throughout the world are ... Doctor After Treatment What`s New in Salivary Gland Cancer Research? Other Resources and References Cancer Information Cancer Basics ...
The Breast Cancer and the Environment Research Program supports a multidisciplinary network of scientists, clinicians, and community partners to examine the effects of environmental exposures that may predispose a woman to breast cancer throughout her life.
The National Cancer Institute (NCI), through the Office of Cancer Clinical Proteomics Research (OCCPR), has signed two Memorandums of Understanding (MOUs) in the sharing of proteomics reagents and protocols
Constance Lynne Clark 1961
The purpose of this thesis was to examine research on collaborative reading models, the learning of strategies for improving reading comprehension for secondary students of English as a second or foreign language (hereafter referred to as the L2), and to provide intervention measures that target struggling readers before remedial recommendations become necessary. The particular focus draws from research of both native-speaking English language (L1) learners and L2 learners. Few studies are av...
Chan, Clarice S. C.
In the last two decades, a great deal of applied linguistics research has been conducted in different areas of business English. However, despite many highly relevant research findings, the interface between research and pedagogy remains weak. One reason behind this lack of interface is that research findings from different studies are rarely…
Shatz, Marilyn, Ed.; Wilkinson, Louise C., Ed.
This comprehensive volume describes evidence-based strategies for supporting English language learners (ELLs) by promoting meaningful communication and language use across the curriculum. Leading experts explain how and why learning is different for ELLs and pinpoint specific best practices for the classroom, illustrated with vivid examples.…
Ana I. Moreno
Full Text Available Previous quantitative studies suggest that the burden researchers who use English as an additional language perceive when writing research articles (RAs for publication in English (as L2 is 24% greater than the burden they perceive when they write RAs for publication in their L1. It remains unclear precisely which aspects of research article (RA writing in English present these writers with the greatest challenge and just why they perceive this increase in difficulty. A structured questionnaire comprising thirty-seven questions about researchers’ publication experiences in scientific journals in English and in Spanish was designed and sent out to all (n = 8,794 Spanish postdoctoral researchers at one research-only institution and four universities in Spain, yielding responses from 1,717 researchers. Our first results show that the discussion is the section that is perceived as more difficult to write for English-medium journals, across the four broad knowledge areas in a way that cannot be fully explained by their lower level of proficiency in English (as L2. This article proposes the rhetorical transfer hypothesis as a possible explanation for their additional difficulty. Our results also reveal that their increased perceived difficulty writing RA discussions in English (as L2 does not decrease noticeably until Spanish researchers report high or very high levels of proficiency in English (as L2 for academic or general purposes or have published on average at least 37 RAs as corresponding author in English-medium journals over the last ten years. Implications for English for Academic Purposes (EAP research and pedagogy are discussed.
Lee, Jong In; Hwang, Dae Yong; Bang, Ho Yoon [and others
Basic Research on Cancer related to Radiation Associated Medical Researches including 1. Establishment of animal model of colorectal cancer liver metastasis and measurement of angiogenesis, 2. Tissue expression of Tie-1 and Tie-2 in human colorectal cancer, 3. Enhancement of G2/Mphase Cell Fraction by Adenovirus-mediated p53 Gene Transfer in Ovarian Cancer Cell Lines, 4. Clinical Characteristics of the patients with Non-B Non-C Hepatocellular Carcinoma and Frequency of HBV, HCV and TTV Viremia in these Patients, 5. Significance of serum iron and ferritin in patients with stomach cancer, 6. Telomerase assay for early detection of lung cancer, 7. Study on the Usefulness of Aldehyde dehydrogenase-2 Genotyping for Risk Group of Alcohol-related Cancer Screening, 8. Gene therapy using hepatoma specific promoter, 9. Study on the Influence of DNA repair gene, XRCC1 Genotypes on the Risk of Head and Neck Cancer were performed.
Basic Research on Cancer related to Radiation Associated Medical Researches including 1. Establishment of animal model of colorectal cancer liver metastasis and measurement of angiogenesis, 2. Tissue expression of Tie-1 and Tie-2 in human colorectal cancer, 3. Enhancement of G2/Mphase Cell Fraction by Adenovirus-mediated p53 Gene Transfer in Ovarian Cancer Cell Lines, 4. Clinical Characteristics of the patients with Non-B Non-C Hepatocellular Carcinoma and Frequency of HBV, HCV and TTV Viremia in these Patients, 5. Significance of serum iron and ferritin in patients with stomach cancer, 6. Telomerase assay for early detection of lung cancer, 7. Study on the Usefulness of Aldehyde dehydrogenase-2 Genotyping for Risk Group of Alcohol-related Cancer Screening, 8. Gene therapy using hepatoma specific promoter, 9. Study on the Influence of DNA repair gene, XRCC1 Genotypes on the Risk of Head and Neck Cancer were performed
Joyita Banerjee; Neetu Mishra; Yogita Dhas
Metagenomics has broadened the scope of targeting microbes responsible for inducing various types of cancers. About 16.1% of cancers are associated with microbial infection. Metagenomics is an equitable way of identifying and studying micro-organisms within their habitat. In cancer research, this approach has revolutionized the way of identifying, analyzing and targeting the microbial diversity present in the tissue specimens of cancer patients. The genomic analyses of these micro-organisms t...
A variety of datasets from genome-wide association studies of cancer and other genotype-phenotype studies, including sequencing and molecular diagnostic assays, are available to approved investigators through the Extramural National Cancer Institute Data Access Committee.
Studying the autonomous learning motivation and excitation model can stimulate intrinsic motivation of foreign language learners,develop students self-management strategy evaluation are very necessary.The purpose of this paper is to give students the skills of listening and speaking for their autonomous learning.Then study the cultivation and motivation of college English students autonomous learning,hoping to make students to learn autonomous learning and stimulate their motivation fully.
Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characterization of new molecular markers and the discovery of novel targeted therapies are two main goals in colorectal cancer translational research. However, the straightforward translation of basic research findings, specifically into colorectal cancer treatment and vice versa is still underway. In the present paper, a summarized view of some of the new available approaches on colorectal cancer translational research is provided. Pros and cons are discussed for every approach exposed.
Perryman, Lara; Erler, Janine Terra
Metastasis is the main reason for cancer-associated deaths and therapies are desperately needed to target the progression of cancer. Lysyl oxidase (LOX) plays a pivotal role in cancer progression, including metastasis, and is therefore is an attractive therapeutic target. In this review we will...
Dajani, Majida "Mohammed Yousef "
This study aimed to describe the implementation of individual action research projects among some forty English language teachers distributed in thirty Palestinian schools in Ramallah and Qabatya districts-Palestine. It aimed to analyze the outcomes of the teachers' action research as part of a broader participatory action research project that is…
English writing plays an indispensible part in EFL (English as a Foreign Language) learning for Chinese students, which accounts for a high score in an English test in China. And it is also a comprehensive reflection of students' abilities in L2 application. However, most non-English majors in vocational and technical colleges have great trouble…
The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health are offering a one week educational opportunity in "Nutrition and Cancer Prevention Research" for individuals with a sustained commitment to nutrition and health promotion. This one-week intense learning session provides specialized instruction in the role of diet and bioactive food components as modifiers of cancer incidence and tumor behavior. |
The Division of Cancer Prevention supports major scientific collaborations and research networks at more than 100 sites across the United States. Five Major Programs' sites are shown on this map. | The Division of Cancer Prevention supports major scientific collaborations and research networks at more than 100 sites across the United States.
... resources for bone cancer What’s new in bone cancer research and treatment? Research on bone cancer is now ... Your Doctor After Treatment What`s New in Bone Cancer Research? AdditionalResources Other Resources and References Cancer Information Cancer ...
Humaida, Ibrahim Abdelrahim Ibrahim
This research was conducted to achieve the following objectives: to examine motivation to learn English language among students of faculty of arts, Islamic University-Sudan, to find out if there were significant statistical differences on motivation scores related to both student level and age. To pursue these objectives, the researcher used the…
In this article, the author discusses ways in which teachers can implement brain-based research in teaching English language learners (ELLs). Teachers of ELLs can draw on recently developed brain-based research applied to other learners, in addition to their considerations of multicultural strategies, learning styles, and diverse needs. Equipped…
Paulo J G Lisboa; Vellido Alcacena, Alfredo; Tagliaferri, Roberto; Napolitano, Francesco; Ceccarelli, Michelle; Martín Guerrero, José D.; Biganzoli, Elia
This article is not intended as a comprehensive survey of data mining applications in cancer. Rather, it provides starting points for further, more targeted, literature searches, by embarking on a guided tour of computational intelligence applications in cancer medicine, structured in increasing order of the physical scales of biological processes.
Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characteriz...
Afsaneh Dehnad; Hayedeh Nasser
Action research is an attempt to seek immediate solutions to the problems experienced in educational settings. In this type of research, teachers are the researchers who intend to make instant reforms to develop, and improve their teaching styles and reflect on pedagogical practices. The purpose of this study was to conduct an action research to tackle the problem of students' low motivation in English classes at the medical school of Iran University of Medical Sciences in fall 2010. Particip...
Full Text Available In this review, we take a survey of bioinformatics databases and quantitative structure-activity relationship studies reported in published literature. Databases from the most general to special cancer-related ones have been included. Most commonly used methods of structure-based analysis of molecules have been reviewed, along with some case studies where they have been used in cancer research. This article is expected to be of use for general bioinformatics researchers interested in cancer and will also provide an update to those who have been actively pursuing this field of research.
During the past 250 years, we have witnessed many landmark discoveries in our efforts to make progress against cancer, an affliction known to humanity for thousands of years. This timeline shows a few key milestones in the history of cancer research.
Understanding the exposures and risk factors that cause cancer, as well as the genetic abnormalities associated with the disease, has helped us to reduce certain exposures and to ameliorate their harmful effects.
Full Text Available Reading research articles in English will be a special challenge for those students who speak English as a foreign language (EFL. EFL graduate students will require a specific method for helping them to cope with the articles they have to read. This study tries to offer a method for helping them to read, understand, and analyze English articles easier. This study employs evaluation and trialing. It is accompanied by pre and post surveys that will give information about the condition of the students before and after the method is implemented. This study involved graduate students majoring in Information Systems at Satya Wacana Christian University. It is expected that the method proposed will help the students to know exactly what they need to read and focus on when they read a research article so that they can use their time more efficiently and effectively.
Part of NCI’s Division of Cancer Biology’s research portfolio, studies supported include the characterization of basic mechanisms relevant to anti-tumor immune responses and hematologic malignancies.
... Transmitted Diseases NIH Research Leads to Cervical Cancer Vaccine Past Issues / Fall 2008 Table of Contents For ... Douglas Lowy (left) and John Schiller developed the vaccine to prevent HPV infection in women, the cause ...
With the rapid pace of globalization,English has become the global language or international language which is playing all increasingly important role in international communication. Inevitably involved in this process,China has experienced all up⁃ surge of English learning. The author drawing support from the theories in sociolinguistics and intercultural communication, And analysis the sets of teaching materials used in college English class, for example, The New Horizon College English. The unbal⁃ anced proportion of Chinese culture input to western culture input in textbooks is one of the main reasons why Chinese college stu⁃ dents are incompetent in expressing Chinese culture in English.
Full Text Available Metagenomics has broadened the scope of targeting microbes responsible for inducing various types of cancers. About 16.1% of cancers are associated with microbial infection. Metagenomics is an equitable way of identifying and studying micro-organisms within their habitat. In cancer research, this approach has revolutionized the way of identifying, analyzing and targeting the microbial diversity present in the tissue specimens of cancer patients. The genomic analyses of these micro-organisms through next generation sequencing techniques invariably facilitate in recognizing the microbial population in biopsies and their evolutionary relationships with each other. In this review an attempt has been made to generate current metagenomic view on cancer microbiota. Different types of micro-organisms have been found to be linked to various types of cancers, thus, contributing significantly in understanding the disease at molecular level.
Design based research (DBR) is an appropriate method for small scale educational research projects involving collaboration between teachers, students and researchers. It is particularly useful in collaborative projects where an intervention is implemented and evaluated in a grounded context. The intervention can be technological, or a new program…
Olli Yli-Harja; Antti Ylip(a)(a); Matti Nykter; Wei Zhang
In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results. The essence of signal processing is to describe the natural world by mathematical models and then, based on these models, develop efficient computational tools for solving engineering problems. Here, we underline, with examples, the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers. Based on this approach, a new field has emerged, called cancer systems biology. Despite its short history, cancer systems biology has already produced several success stories tackling previously impracticable problems. Perhaps most importantly, it has been accepted as an integral part of the major endeavors of cancer research, such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas (TCGA) project. Finally, we show that signal processing and cancer research, two fields that are seemingly distant from each other, have merged into a field that is indeed more than the sum of its parts.
... SEE A LIST » What’s new in prostate cancer research? Previous Topic Second cancers after prostate cancer Next Topic Additional resources for prostate cancer What’s new in prostate cancer research? Research into the causes , prevention , detection , and treatment ...
Duncan, Lindsay R; Martinez, Josefa L; Rivers, Susan E.; Latimer, Amy E.; Bertoli, Michelle C; Domingo, Samantha; Salovey, Peter
We conducted a pre–post feasibility trial of Healthy Eating for Life, a theory-based, multimedia English as a second language curriculum that integrates content about healthy nutrition into an English language learning program to decrease cancer health disparities. Teachers in 20 English as a second language classrooms delivered Healthy Eating for Life to 286 adult English as a second language students over one semester. Postintervention data are available for 227 students. The results indica...
Jenkins, Jennifer; Cogo, Alessia; Dewey, Martin
We begin by considering how the recent phenomenon of English as a Lingua Franca (henceforth ELF) fits in with the older notion of lingua francas in general as well as with older versions of ELF. We then explore the beginnings of ELF in its modern manifestation, including the earliest ELF research, and tackle the thorny issue of defining ELF. After…
This is a study to focus on analyzing the use of constructive teaching method toward the students' motivation in learning content subject of Introduction to Research of English Language Teaching. By using a mix-method of qualitative and quantitative analysis, the data are collected by using questionnaire and classroom observation. The…
In Waters (2009), the author attempted to capture the "state of the art" in theorising, practice, and research activity about the management of innovation in English language education (ELE). In this article, he reprises a number of areas in that review, to identify where the field would benefit from further enquiry about how to…
This paper explores the field of post-compulsory English Language Teaching (ELT) management research, enquiring into its identity, legitimacy and development, by identifying and discussing issues, problems, and controversies. It reviews the nature of the ELT sector as a predominantly commercial educational service with a significant role in "inner…
Brolan, Claire E.; Gomez, Miriam Taylor; Lennox, Nicholas G.; Ware, Robert S.
The authors review available data on Australians from a non-English speaking background (NESB) with intellectual disability (ID). They find that intellectual disability in the Australian NESB community has received limited attention in terms of both qualitative and quantitative research. The existing literature is over 10 years old and is relevant…
Mirzapour, Fatemeh; Ahmadi, Maryam
The present study aims to analyze comparatively English and Persian research articles (Linguistics, Literature, and Library and Information disciplines) in terms of number and degree of utilization of sub-types of lexical cohesion in order to appreciate textualization processes in the two languages concerned. The study analyzes 60 research…
Amnuai, Wirada; Wannaruk, Anchalee
This study investigates the rhetorical move structure of English applied linguistic research article Discussions published in Thai and international journals. Two corpora comprising of 30 Thai Discussions and 30 international Discussions were analyzed using Yang & Allison's (2003) move model. Based on the analysis, both similarities and…
The purpose of the study is to identify the effect of the research assessment exercise (RAE) on the balance between collegiality and managerialism in English universities. The article examines the institutional strategies for the 2001 RAE and its effect on organisational culture, identifying change in governance, management and leadership in…
Tellez, Kip; Waxman, Hersh C.
This article synthesized current research on effective communities for English Language Learners (ELLs). The findings are discussed under the following categories: parents, community resources, and peers. The results of the review indicate that parenting programs are effective, but they must be carefully developed and often require specific…
Mirhosseini, Seyyed-Abdolhamid; Ghafar Samar, Reza
Mainstream trends of English language teaching (ELT) are predominantly constructed within the epistemological boundaries shaped by the traditional conceptions of linguistics, learning, and teaching as well as positivist research methodology. What tends to be overshadowed by such conceptions is the underlying foundational belief structure of ELT…
Stomach cancers fall into four distinct molecular subtypes, researchers with The Cancer Genome Atlas (TCGA) Network have found. Scientists report that this discovery could change how researchers think about developing treatments for stomach cancer, also c
... resources for liver cancer What`s new in liver cancer research and treatment? Because there are only a few ... or treat hepatitis infections before they cause liver cancers. Research into developing a vaccine to prevent hepatitis C ...
Infectious Agents and Cancer Epidemiology Research Webinar Series highlights emerging and cutting-edge research related to infection-associated cancers, shares scientific knowledge about technologies and methods, and fosters cross-disciplinary discussions on infectious agents and cancer epidemiology.
The history of research into dictionary use tends to be characterised by small-scale studies undertaken in a variety of different contexts, rather than larger-scale, longer-term funded projects. The research conducted by dictionary publishers is not generally made public, because of its commercial sensitivity, yet because dictionary production is…
Lee, Seung Hoon; Yoo, Young Do; Hong, Seok Il [and others
We studied the mechanism of radiation-induced apoptosis, the factors involved signaling, and the establishment of radiation-resistant cell lines in this study. During the TGF beta-stimulated epithelial mesenchymal transition(EMT), actin rearrangement occurred first and fibronectin matrix assembly followed. These two events were considered independent since cytochalasin-D did not inhibit TGF stimulated matrix assembly and fibronectin supplementation did not induce EMT. During EMT, alpha 5 beta 1 integrin and alpha v integrin have increased but MMP activation was not accompanied, which suggest that induction of extracellular matrix and activation of integrins may be main contributor for the EMT. Serum depriving induced apoptosis of HUVECs was prevented by vascular endothelial growth factor(VEGF) and PMA. The apoptosis prevention by VEGF and PMA were conformed by DNA fragmentation assay. The p53 expression level was down regulated by VEGF and PMA compared with serum deprived HUVECs. However, VEGF and PMA induces c-Myc expression level on these cells. We made the 5 radiation-resistant clones from breast, lung and cervical cancer cells. More than 70%, 100% and 50% increased resistance was detected in breast cancer cells, lung cancer cells, and cervical cells, respectively. We carried out differential display-PCR to clone the radiation-resistant genes. 9 out of 10 genes were analyzed their sequence.
We studied the mechanism of radiation-induced apoptosis, the factors involved signaling, and the establishment of radiation-resistant cell lines in this study. During the TGF beta-stimulated epithelial mesenchymal transition(EMT), actin rearrangement occurred first and fibronectin matrix assembly followed. These two events were considered independent since cytochalasin-D did not inhibit TGF stimulated matrix assembly and fibronectin supplementation did not induce EMT. During EMT, alpha 5 beta 1 integrin and alpha v integrin have increased but MMP activation was not accompanied, which suggest that induction of extracellular matrix and activation of integrins may be main contributor for the EMT. Serum depriving induced apoptosis of HUVECs was prevented by vascular endothelial growth factor(VEGF) and PMA. The apoptosis prevention by VEGF and PMA were conformed by DNA fragmentation assay. The p53 expression level was down regulated by VEGF and PMA compared with serum deprived HUVECs. However, VEGF and PMA induces c-Myc expression level on these cells. We made the 5 radiation-resistant clones from breast, lung and cervical cancer cells. More than 70%, 100% and 50% increased resistance was detected in breast cancer cells, lung cancer cells, and cervical cells, respectively. We carried out differential display-PCR to clone the radiation-resistant genes. 9 out of 10 genes were analyzed their sequence
David I. Méndez
Full Text Available In this study, we carry out a qualitative and quantitative analysis of abbreviations in 300 randomly collected research paper titles published in the most prestigious European and US-based Astrophysics journals written in English. Our main results show that the process of shortening words and groups of words is one of the most characteristic and recurrent features in Astrophysics research paper titling construction. In spite of the convenience of abbreviations as a mechanism for word-formation, some of them may pose certain difficulties of understanding and/or misinterpretation because of their specificity, ambiguity, or overlapping. To overcome these difficulties, we propose a series of options which with no doubt would lead to a better interaction among the different branches of Astrophysics in particular and of science in general and would definitely improve how research is currently performed and communicated.Keywords: Abbreviations; Astrophysics; English; Research Papers
Schatzkin, A; Dorgan, J; Swanson, C; Potischman, N
In light of several credible diet and cancer hypotheses, we suggest strategies for advancing our understanding in this area. Two conceptual approaches can be taken in defining dietary exposure: the decompositional approach focuses on specific nutrients and other chemical constituents of food, whereas the integrative approach emphasizes the action of whole foods or food patterns (cuisines). Diet-cancer hypotheses can be organized according to this conceptual framework. We review four types of scientific investigation available to us for advancing the diet and cancer field: metabolic (clinical nutrition) studies; animal studies; observational epidemiologic investigations; and clinical trials. Each of these designs has its strengths and limitations. Observational epidemiologic studies and trials have the particular advantage of examining explicit cancer end points in humans. Results from metabolic and animal research, however, can complement the findings from epidemiologic studies and trials. Finally, we briefly review strategies for evaluating promising hypotheses linking diet to cancers of the large bowel, lung, breast, and prostate. PMID:8741779
"An international collaboration of scientists has completed the first ever antiproton beam experiments designed to reveal the biological effectiveness of antiproton radiation in terminating cells used for cancer research...PBar Labs assembled the collaboration at CERN (European Organization for Nuclear Research in Geneva) to perform the measurements" (1 page).
Numerical phases have rich cultural connotations and connect closely with culture. Along with the extension of China’s reform and opening up policy, cross-cultural communication tends to be wider. The comparative research on cross-cultural languages is very important. Because of different cultural backgrounds, the cultural connotations of Chinese and English numerical phases are quite different. This paper tries to make a comparative research on the cultural connotations of numerical phases (...
The Breast and Gynecologic Cancer Research Group conducts and fosters the development of research on the prevention and early detection of breast cancer, cervix and human papillomavirus (HPV)-related cancers, endometrial cancers, ovarian cancers, and precursor conditions related to these cancers. |
Fortney, Kristen; Jurisica, Igor
Over the past two decades, high-throughput (HTP) technologies such as microarrays and mass spectrometry have fundamentally changed clinical cancer research. They have revealed novel molecular markers of cancer subtypes, metastasis, and drug sensitivity and resistance. Some have been translated into the clinic as tools for early disease diagnosis, prognosis, and individualized treatment and response monitoring. Despite these successes, many challenges remain: HTP platforms are often noisy and ...
... SEE A LIST » What’s new in pancreatic cancer research? Previous Topic Living as a pancreatic cancer survivor Next Topic Additional resources for pancreatic cancer What’s new in pancreatic cancer research? Research into the causes , diagnosis , and treatment of ...
With the technology development of network information, there exists more and more seriously questions to our education. Computer multimedia application breaks the traditional foreign language teaching and brings new challenges and opportunities for the education. Through the multiple media application, the teaching process is full of animation, image, voice, and characters. This can improve the learning initiative and objective with great development of learning efficiency. During the traditional foreign language teaching, people use characters learning. However, through this method, the theory performance is good but the practical application is low. During the long time computer multimedia application in the foreign language teaching, many teachers still have prejudice. Therefore, the method is not obtaining the effect. After all the above, the research has significant meaning for improving the teaching quality of foreign language.
Rabi, Sally A
Following an action research framework, my research investigates professional development for English Language teachers in the Arab World, who are non-native speakers of English themselves. The thesis has five chapters: Literature Review, Critical Contexts, Methodology of the Study, Data Analysis and Presentation, and finally the Discussion and Findings of the research. The Literature Review covers works relevant to the area of the study in relation to existing teacher practices, te...
De Paoli, Paolo
The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The success or failure of a shared resource program also depends on the choice of appropriate institutional policies and requires an effective institutional governance regarding decisions on staffing, existence and composition of advisory committees, policies and of defined mechanisms of reporting, budgeting and financial support of each resource. Shared Resources represent a widely diffused model to sustain cancer research; in fact, web sites from an impressive number of research Institutes and Universities in the U.S. contain pages dedicated to the SR that have been established in each Center, making a complete view of the situation impossible. However, a nation-wide overview of how Cancer Centers develop SR programs is available on the web site for NCI-designated Cancer Centers in the U.S., while in Europe, information is available for individual Cancer centers. This article will briefly summarize the institutional policies, the organizational needs, the characteristics, scientific aims, and future developments of SRs necessary to develop effective translational research programs in oncology.In fact, the physical build-up of SRs per se is not sufficient for the successful translation of biomedical research. Appropriate policies to improve the academic culture in collaboration, the availability of educational programs for translational investigators, the existence of administrative facilitations for translational research and an efficient organization supporting clinical trial recruitment
De Paoli Paolo
Full Text Available Abstract The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The success or failure of a shared resource program also depends on the choice of appropriate institutional policies and requires an effective institutional governance regarding decisions on staffing, existence and composition of advisory committees, policies and of defined mechanisms of reporting, budgeting and financial support of each resource. Shared Resources represent a widely diffused model to sustain cancer research; in fact, web sites from an impressive number of research Institutes and Universities in the U.S. contain pages dedicated to the SR that have been established in each Center, making a complete view of the situation impossible. However, a nation-wide overview of how Cancer Centers develop SR programs is available on the web site for NCI-designated Cancer Centers in the U.S., while in Europe, information is available for individual Cancer centers. This article will briefly summarize the institutional policies, the organizational needs, the characteristics, scientific aims, and future developments of SRs necessary to develop effective translational research programs in oncology. In fact, the physical build-up of SRs per se is not sufficient for the successful translation of biomedical research. Appropriate policies to improve the academic culture in collaboration, the availability of educational programs for translational investigators, the existence of administrative facilitations for translational research and an efficient organization
Pérez Sabater, Carmen; Montero Fleta, Maria Begoña; Pérez Sabater, Mª Luisa
The study we present forms part of an ongoing study on the introduction of the Common European Framework of Reference for Languages (CEFR) in tertiary education. Our research aims at promoting the adequate use of workplace language by analysing the ability of non-native speakers of English to differentiate speech styles. Special attention has been devoted to the adequate use of powerful and powerless language in mock job interviews. © 2013 The Authors. Published by Elsevier Ltd. O...
Jenkins, Jennifer; Cogo, Alessia; Dewey, Martin
We begin by considering how the recent phenomenon of English as a Lingua Franca (henceforth ELF) fits in with the older notion of lingua francas in general as well as with older versions of ELF. We then explore the beginnings of ELF in its modern manifestation, including the earliest ELF research, and tackle the thorny issue of defining ELF. After discussing the main locations and domains in which ELF research has been carried out to date, we move on to examining research into three linguisti...
Celis, Julio E; Gromova, Irina; Moreira, José Manuel Alfonso;
Detecting bladder cancer at an early stage and predicting how a tumor will behave and act in response to therapy, as well as the identification of new targets for therapeutic intervention, are among the main areas of research that will benefit from the current explosion in the number of powerful ...
This dissertation explores motivation in decision-making and action in science and technology, through the lens of a case study: scientific data sharing in cancer research. The research begins with the premise that motivation and emotion are key elements of what it means to be human, and consequently, are important variables in how individuals make decisions and take action. At the same time, institutional controls and social messaging send a variety of signals intended to motivate specific ...
... For Breast Cancer Selected National Cancer Institute Breast Cancer Research Topics Past Issues / Summer 2014 Table of Contents ... Trials www.cancer.gov/clinicaltrials/Taking-Part-in-Cancer-Treatment-Research-Studies MedlinePlus tutorial www.nlm.nih.gov/medlineplus/ ...
Barker, Anna D.
Cancer is increasingly described as a ''disease of the genes'', and while the genome (in fact all of the ``omes'') are important information molecules that drive aspects of the initiation and progression of cancer, they are far from the whole story. Cancer is an extraordinarily complex system (in fact a complex of systems) that occurs in three-dimensional space, across multiple scales - and often over extended periods of time. The most challenging issues that plague the cancer field such as metastasis, cellular heterogeneity and resistance to therapy are in large part more rationally explained in the context of the physics of these systems vs. genomics. For example, the biology of metastasis has been studied extensively for decades with little progress. Metastatic disease depends on cells acquiring (or expressing innate information) new properties that enable and sustain their ability to migrate to distant sites. Developing a fundamental understanding of key cancer processes ranging from metastasis to immunotherapeutic responses requires that physicists (and mathematicians and engineers) be integrated into a new generation of cancer research - period! The presentation will focus on those areas where physics is essential - and the how's and whose of achieving the integration required.
National Oceanic and Atmospheric Administration, Department of Commerce — The present volume contains data collected in 1959 by English research vessels at serial and surface hydrographic stations. The data list are preceded by a number...
... Download Printable Version [PDF] » What`s New in Esophagus Cancer Research? TOPICS Document Topics GO » SEE A LIST » What’s ... Your Doctor After Treatment What`s New in Esophagus Cancer Research? Other Resources and References Cancer Information Cancer Basics ...
Full Text Available With the advent of molecular targeted therapies and the development of high-throughput biotechnologies, it has become evident that progress in cancer research is largely due to the creation of multidisciplinary teams able to plan clinical trials supported by appropriate molecular hypotheses. These efforts have culminated in the identification and validation of biomarkers predictive of response, as well as in the generation of more accurate prognostic tools. The identification of cancer stem cells has provided further insights into mechanisms of cancer, and many studies have tried to translate this biological notion into prognostic and predictive information. In this regard, new agents targeting key stemness-related pathways have entered the clinical development, and preliminary data suggested an encouraging antitumor activity.
Full Text Available Thyroid cancer is the most common endocrine malignancy with four major types distinguished on the basis of histopathological features: papillary, follicular, medullary, and anaplastic. Classification of thyroid cancer is the primary step in the assessment of prognosis and selection of the treatment. However, in some cases, cytological and histological patterns are inconclusive; hence, classification based on histopathology could be supported by molecular biomarkers, including markers identified with the use of high-throughput “omics” techniques. Beside genomics, transcriptomics, and proteomics, metabolomic approach emerges as the most downstream attitude reflecting phenotypic changes and alterations in pathophysiological states of biological systems. Metabolomics using mass spectrometry and magnetic resonance spectroscopy techniques allows qualitative and quantitative profiling of small molecules present in biological systems. This approach can be applied to reveal metabolic differences between different types of thyroid cancer and to identify new potential candidates for molecular biomarkers. In this review, we consider current results concerning application of metabolomics in the field of thyroid cancer research. Recent studies show that metabolomics can provide significant information about the discrimination between different types of thyroid lesions. In the near future, one could expect a further progress in thyroid cancer metabolomics leading to development of molecular markers and improvement of the tumor types classification and diagnosis.
... escape to close saved articles window. My Saved Articles » My ACS ... in colorectal cancer research? Research is always going on in the area of colorectal cancer. Scientists are looking for causes and ways to prevent ...
During the course of English teaching in middle schools, grammar teaching is always a focus argued about by English researchers and English teachers- -Is it necessary to teach grammar？ Which approach or method td grammar teaching may help the students improve the effects of learning a foreign language and enhance their ability to use the foreign language？ In view of this circumstance, the author does an experiment on teaching grammar in the framework of CLT to prove whether CLT is really more effective for students to master grammar knowledge than traditional method and whether CLT can improve the students＇ ability to express themselves freely, properly and fluently.
Full Text Available In recent years, genre studies have attracted the attention of many researchers. The aim of the present study was to observe the differences in generic structure of abstract written by English native and non-native (Iranian students in two disciplines of mathematics and applied linguistics. To this end, twenty native English students’ abstract texts from each discipline and the same number of non-native (Iranian ones were selected. In this study, Hyland’s (2000 five‐move model was used to identify the rhetorical structure of the four sets of texts. After analyzing each text, the main moves were extracted and the frequencies of each one were calculated and compared. The cross-disciplinary and cross‐linguistic analyses reveal that linguistics abstracts follow a conventional scheme, but mathematics abstracts in these two languages do not exhibit the usual norms in terms of moves. Besides, greater difference in move structure is seen across languages in mathematics. The findings of the study have some pedagogical implications for academic writing courses for graduate students, especially students from non-English backgrounds in order to facilitate their successful acculturation into these disciplinary communities.Keywords: Genre Analysis, mathematics, applied linguistics
Pankaj Agarwal; Kouros Owzar
Advances in next generation sequencing (NGS) and mass spectrometry (MS) technologies have provided many new opportunities and angles for extending the scope of translational cancer research while creating tremendous challenges in data management and analysis. The resulting informatics challenge is invariably not amenable to the use of traditional computing models. Recent advances in scalable computing and associated infrastructure, particularly distributed computing for Big Data, can provide ...
The Lung and Upper Aerodigestive Cancer Research Group conducts and supports research on the prevention and early detection of lung and head and neck cancers, as well as new approaches to clinical prevention studies including cancer immunoprevention.Phase 0/I/II Cancer Prevention Clinical Trials ProgramThe group jointly administers the Phase 0/I/II Cancer Prevention Clinical Trials Program evaluating new agents, surrogate biomarkers, and technologies to identify premalignant lesions, and related cancers. |
In association with clinical study of carbon beam therapy for lung cancer, the basic research for lung cancer and the patients with this disease has been carried out for the past 10 years. With regard to lung damage by the carbon beams, firstly pulmonary function was measured and analyzed for the patients with stage I non-small cell lung cancer. Force expiratory volume in 1 second (FVE 1.0) and TLC (total lung capacity) was found to be reduced significantly at 6 and 12 months after therapy but the reduction rate was a little, which can support the safety of this treatment modality. Secondly, the regional lung damage by the beams was investigated by using correct fusion of CT images with carbon beam dose distribution, diagnostic follow-up CT images and blood flow and ventilation spect images. It demonstrated the graded decrease blood flow by dose and the compensatory increase of blood flow in the adjacent lobe of lung unexposed to irradiation. On the other hand, the biological study of carbon beam effects on lung cancer cells and tumors line was conducted. Firstly, by using 7 or 4 human lung cancer cell line, the radiosensitivity of carbon beams was compared with that of photons by different histological patterns. It was found that there was no essential difference in the sensitivity pattern for lung cancer histology between the carbon beams and photons though the former doubled the later in power. Secondly, by using IA cell lines among them, the dynamic of clonogenic cells (clonogen) in a nude tumor and the changes in its morphology following irradiation was investigated, clarifying that the clonogen proliferating under anoxic or hypoxic conditions played a pivotal role for tumor regrowth and stemmed from the different clone which had been genetically selected and developed under these conditions. The finding of clonogen becomes one of the evidence supporting the superiority of a single-dose radiotherapy to fractionated radiotherapy. (author)
Mayer, Deborah K
Nursing research and nurse researchers have been an integral and significant part of the Oncology Nursing Society's (ONS's) history, as evidenced by the development of the Nursing Research Committee within a few years of ONS's establishment. Ruth McCorkle, PhD, RN, FAAN, was the committee's first chairperson in 1979. This was followed by the creation of the Advanced Nursing Research Special Interest Group in 1989 under the leadership of Jean Brown, PhD, RN, FAAN. ONS also began to recognize nurse researchers in 1994 by creating the annual ONS Distinguished Researcher Award to recognize the contributions of a member who has conducted or promoted research that has enhanced the science and practice of oncology nursing. The list of recipients and of their work is impressive and reflects the wide range of our practice areas (see http://bit.ly/1MTC5cp for the recipient list). In addition, the ONS Foundation began funding research in 1981 and has distributed more than $24 million in research grants, research fellowships, and other scholarships, lectures, public education projects, and career development awards (ONS Foundation, 2015). And, in 2006, the Putting Evidence Into Practice resource was unveiled, which provides evidence-based intervention reviews for the 20 most common problems experienced by patients with cancer and their caregivers (www.ons .org/practice-resources/pep) . PMID:26302272
Full Text Available Abstract Background Despite the pressing need for the creation of applications that facilitate the aggregation of clinical and molecular data, most current applications are proprietary and lack the necessary compliance with standards that would allow for cross-institutional data exchange. In line with its mission of accelerating research discoveries and improving patient outcomes by linking networks of researchers, physicians, and patients focused on cancer research, caBIG (cancer Biomedical Informatics Grid™ has sponsored the creation of the caTRIP (Cancer Translational Research Informatics Platform tool, with the purpose of aggregating clinical and molecular data in a repository that is user-friendly, easily accessible, as well as compliant with regulatory requirements of privacy and security. Results caTRIP has been developed as an N-tier architecture, with three primary tiers: domain services, the distributed query engine, and the graphical user interface, primarily making use of the caGrid infrastructure to ensure compatibility with other tools currently developed by caBIG. The application interface was designed so that users can construct queries using either the Simple Interface via drop-down menus or the Advanced Interface for more sophisticated searching strategies to using drag-and-drop. Furthermore, the application addresses the security concerns of authentication, authorization, and delegation, as well as an automated honest broker service for deidentifying data. Conclusion Currently being deployed at Duke University and a few other centers, we expect that caTRIP will make a significant contribution to further the development of translational research through the facilitation of its data exchange and storage processes.
Full Text Available Despite the increasing demands on many multilingual scholars outside the centre(s of scientific knowledge production to publish their research in international scholarly journals, the support for such academic writing for publication is uneven at best. Existing English for research publication purposes (ERPP instruction typically aims to aid multilingual scholars in achieving genre-based expectations and/or navigating the submission and review process, but it often does not address the politics of English-language knowledge production. In this paper, informed by an empirical case study and a theory building perspective, we address the need for a sustained program of courses/workshops for multilingual scholars in the (semi- periphery and propose a means of operationalizing a critical-pragmatic approach to such course/workshop content. Our empirically-driven model is informed by the results of a recent case study investigation into an intensive ERPP intervention designed to address multilingual Spanish-speaking L1 scholars’ challenges with writing research articles for publication in indexed (Web of Science international scientific journals. Our model lays the groundwork for a more critical approach to ERPP pedagogy, one that attempts to attend more fully to the needs of multilingual scholars within an asymmetrical market of global knowledge production.
Li, Cui; Hong, Wei
Lung cancer is one of malignant tumors with the highest morbidity and mortality in the world. At present, research of early diagnosis, treatment, prognosis, and metastasis associated biomarkers is most active. This article reviewed the research status of lung cancer biomarkers and analyzed the funding situation in the field of lung cancer markers in recent 10 years in China and abroad, to provide a reference for the future basic and clinical translational research of lung cancer biomarkers.
The main evidences of epidemiology, diagnostic imaging, pathology, surgery, radiotherapy, chemotherapy and follow-up are reviewed to optimize the routine treatment of rectal cancer according to a multidisciplinary approach. This paper reports on the knowledge shared between different specialists involved in the design and management of the multidisciplinary ESTRO Teaching Course on Rectal Cancer. The scenario of ongoing research is also addressed. In this time of changing treatments, it clearly appears that a common standard for large heterogeneous patient groups have to be substituted by more individualised therapies based on clinical-pathological features and very soon on molecular and genetic markers. Only trained multidisciplinary teams can face this new challenge and tailor the treatments according to the best scientific evidence for each patient
Harris, Holly R; Bergkvist, Leif; Wolk, Alicja
The World Cancer Research Fund/American Association for Cancer Research (WCRF/AICR) has published eight nutrition-related recommendations for the prevention of cancer. However, few prospective studies have examined these recommendations by breast cancer hormone receptor subtype and only one case-control study has included the dietary supplements recommendation in their evaluation. We investigated whether adherence to the WCRF/AICR cancer prevention recommendations was associated with breast cancer incidence, overall and by hormone receptor subtype, in the Swedish Mammography Cohort. Among 31,514 primarily postmenopausal women diet and lifestyle factors were assessed with a self-administered food frequency questionnaire. A score was constructed based on adherence to the recommendations for body fatness, physical activity, energy density, plant foods, animal foods, alcoholic drinks and dietary supplements (score range 0-7). Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs). During 15 years of follow-up 1,388 cases of breast cancer were identified. Women who met six to seven recommendations had a 51% decreased risk of breast cancer compared to women meeting only zero to two recommendations (95% CI = 0.35-0.70). The association between each additional recommendation met and breast cancer risk was strongest for the ER-positive/PR-positive subtype (HR = 0.86; 95% CI = 0.79-0.94), while for the ER-negative/PR-negative subtype the individual recommendations regarding plant and animal foods were most strongly associated with reduced risk. Our findings support that adherence to the WCRF/AICR recommendations reduces breast cancer risk in a population of primarily postmenopausal women. Promoting these recommendations to the public could help reduce breast cancer incidence. PMID:26804371
On June 24, 2013, the National Cancer Institute (NCI) Board of Scientific Advisors approved the creation of the NCI Community Oncology Research Program (NCORP). NCORP will bring state-of-the art cancer prevention, control, treatment and imaging clinical trials, cancer care delivery research, and disparities studies to individuals in their own communities. |
Cancer, stroke and heart diseases are most common causes of death. This paper summarized the experience of stroke prevention, which is an enlightenment for cancer research. In addition, this paper also described the progress of cancer epidemiological research, particular the primary and second preventions in China. PMID:26733022
Pilar Mur Dueñas
Full Text Available Intercultural text-based research has shown remarkable differences in the rhetorical structure and devices of research articles (RAs in different linguistic/cultural contexts of publication, including the Spanish local context and the English international context. However, not much attention has been paid to the research article (RA writing process, which can throw light into the publication practices of second language (L2 scholars in particular disciplinary fields and which can help unveil their main writing difficulties. In this paper I focus on the “text histories” of a team of Spanish researchers in the field of Finance who struggle to get their research articles published internationally in English. These text histories correspond to 24 papers drafted and (resubmitted over the past 5-6 years. The analysis focuses on the extent to which they aim to publish their RAs in English, how they cope with writing their texts in English, their success in such a task and the kind of negative comments included in the referee reports they receive. Results show that this team of L2 scholars almost exclusively write their RAs in English and aim at publishing them in English-medium international journals; for this demanding task, they draw on a number of strategies. They are partially successful in that they have managed to publish half of their RAs in the first site where they were submitted. Their manuscripts received a lot of negative comments; especially relevant is the inclusion of a high number of unspecific negative comments related to language or style in major revision reports. Looking into the writing process can be of great help to provide L2 scholars with useful guidelines on drafting their RAs in English for international publication and to gain an insight into the forces driving international publication in this context.
The Prostate and Urologic Cancer Research Group conducts and supports research on prostate and bladder cancers, and new approaches to clinical prevention studies including cancer immunoprevention. The group develops, implements and monitors research efforts in chemoprevention, nutrition, genetic, and immunologic interventions, screening, early detection and other prevention strategies. |
Sepulveda, Adam; Ray, Andrew; Al-Chokhachy, Robert K.; Muhlfeld, Clint C.; Gresswell, Robert E.; Gross, Jackson A.; Kershner, Jeffrey L.
Aquatic invasive species are disrupting ecosystems with increasing frequency. Successful control of these invasions has been rare: Biologists and managers have few tools for fighting aquatic invaders. In contrast, the medical community has long worked to develop tools for preventing and fighting cancer. Its successes are marked by a coordinated research approach with multiple steps: prevention, early detection, diagnosis, treatment options and rehabilitation. The authors discuss how these steps can be applied to aquatic invasive species, such as the American bullfrog (Lithobates catesbeianus), in the Northern Rocky Mountain region of the United States, to expedite tool development and implementation along with achievement of biodiversity conservation goals.
A science writers' seminar to discuss the latest research in cancer genetics and global health efforts, including talks from leaders of NCI’s new centers of cancer genomics and global health will be held Dec. 13, 2011, at NCI.
The National Cancer Institute (NCI), through the Office of Cancer Clinical Proteomics Research (OCCPR), has signed two Memorandums of Understanding (MOUs) in the areas of sharing proteomics reagents and protocols and also in regulatory science.
This paper analyzes the reasons that resulted in silence phenomena in college English classroom teaching,and gives some feasible suggestions to break the classroom silence in English classroom teaching.
Alfred, Lawrence; Beerman, Paula R.; Tahir, Zunera; LaHousse, Sheila F.; Russell, Percy; Sadler, Georgia Robins
The Moores UCSD Cancer Center’s Continuing Umbrella of Research Experiences program aims to increase the number of underrepresented students pursuing careers in cancer research, cancer care, and health disparities research. Participants receive 8 weeks of laboratory and classroom training during the summer followed by participation in research mentors’ laboratories. Of the 82 CURE students accrued (2002 and 2008), 91% persisted in science after 1 year. Of the 63 students eligible to graduate ...
Carlsson, Ulla, Ed.
This listing of researchers and publications in mass communications research in Sweden is integrated into a single list arranged by the name of the researchers and noting their publications (if any) in the appropriate languages. In addition to publications, information provided for each researcher includes title and academic degree, project,…
Looi, L M; Zubaidah, Z; Cheah, P L; Cheong, S K; Gudum, H R; Iekhsan, O; Ikram, S I; Jamal, R; Mak, J W; Othman, N H; Puteri, J N; Rosline, H; Sabariah, A R; Seow, H F; Sharifah, N A
Cancer is a major morbidity and mortality concern in Malaysia. Based on National Cancer Registry data, the Malaysian population is estimated to bear a cancer burden of about 40,000 new cases per year, and a cumulative lifetime risk of about 1:4. Cancer research in Malaysia has to consider needs relevant to our population, and resources constraints. Hence, funding bodies prioritise cancers of high prevalence, unique to our community and posing specific clinical problems. Cancer diagnosis is crucial to cancer management. While cancer diagnosis research largely aims at improvements in diagnostic information towards more appropriate therapy, it also impacts upon policy development and other areas of cancer management. The scope of cancer diagnosis upon which this paper is based, and their possible impact on other R&D areas, has been broadly categorized into: (1) identification of aetiological agents and their linkages to the development of precancer and cancer (impact on policy development, cancer prevention and treatment), (2) cancer biology and pathogenesis (impact on cancer prevention, treatment strategies and product development), (3) improvements in accuracy, sensitivity and specificity in cancer detection, monitoring and classification (impact on technology development) and (4) prognostic and predictive parameters (impact on treatment strategies). This paper is based on data collected by the Working Group on Cancer Diagnosis Research for the First National Conference on Cancer Research Coordination in April 2004. Data was collated from the databases of Institutions/Universities where the authors are employed, the Ministry of Science, Technology and Innovation (MOSTI) and targeted survey feedback from key cancer researchers. Under the 7th Malaysia Plan, 76 cancer projects were funded through the Intensified Research in Priority Areas (IRPA) scheme of MOSTI, amounting to almost RM15 million of grant money. 47(61.8%) of these projects were substantially in cancer
Full Text Available Improving the quality of English language teacher education (ELTE programs has become a major point of consideration; however, such programmatic evaluations are markedly rare. This study utilizes both numeric and interpretive qualitative data in a blended research design. The study addresses, vis-à-vis current research in related fields: What is the current situation of the Turkish ELTE programs in terms of curriculum strength and faculty resources? How do the program directors and teacher candidates envision the situation of their programs in terms of curriculum strength and faculty resources? Data included 45 ELTE curricula, interviews with 24 program directors and pre-service teachers, documents, and test scores. Findings revealed several significant associations between school type (public/private and rank (low/high and the number of faculty with expertise in critical areas in the field. Qualitative critical evaluations suggest both perceptual matches and mismatches between program directors and teacher candidates regarding programmatic strengths and weaknesses.
Zhao, Hui; Tektiridis, Jennifer H.; Zhang, Ning; Chamberlain, Robert M.
In October 2009, The University of Texas MD Anderson Cancer Center hosted a symposium, “Future Directions in Cancer Prevention and Control: Workforce Implications for Training, Practice, and Policy.” This article summarizes discussions and an Internet and literature review by the symposium's Health Services Infrastructure Working Group. We agree on the need for the recognition of Cancer Prevention Health Services Research (CP-HSR) as a unified research field. With advances in cancer screening...
In accordance with the requirement of the Ministry of Education, many Universities and colleges have begun or are beginning to adopt bilingual teaching of non-English-oriented courses with course books in English. The pu~ is to improve students' learning and acquiring of the English language during the process of studying the subject courses, and make them
Harrop, J. Phil; Dean, Julie A.; Paskett, Electra D.
The number of cancer survivors and amount of cancer survivorship research has grown substantially during the past three decades. This paper provides a review of interventional and observational cancer survivorship research efforts as well as a summary of current cancer survivorship research projects being conducted by National Cancer Institute-designated cancer centers in an effort to identify areas that need further attention.
Presley, Carolyn J.; Dotan, Efrat; Soto-Perez-de-Celis, Enrique; Jatoi, Aminah; Mohile, Supriya G.; Won, Elizabeth; Alibhai, Shabbir; Kilari, Deepak; Harrison, Robert; Klepin, Heidi D.; Wildes, Tanya M.; Mustian, Karen; Demark-Wahnefried, Wendy
Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research. PMID:27197919
Presley, Carolyn J; Dotan, Efrat; Soto-Perez-de-Celis, Enrique; Jatoi, Aminah; Mohile, Supriya G; Won, Elizabeth; Alibhai, Shabbir; Kilari, Deepak; Harrison, Robert; Klepin, Heidi D; Wildes, Tanya M; Mustian, Karen; Demark-Wahnefried, Wendy
Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research. PMID:27197919
Nickerson, C.; Planken, B.C.
Introducing Business English provides a comprehensive overview of this topic, situating the concepts of Business English and English for Specific Business Purposes within the wider field of English for Special Purposes. This book draws on contemporary teaching and research contexts to demonstrate th
Ovarian cancer is ne of the most lethal malignant tumors in China,represents the third most common cancer after cervical cancer and endometrial cancer,and the first leading cause of death from hynaecological cancers.Due to the lack of effective screening strategies and the absence of symptoms in early-stage of disease,over 70% of patients present at an advanced stage.Despite the advances in surgical techniques and conventional chemotheraphy,the prognosis of ovarian cancer has not been improved significantly,and indeed the long-term survival for patients with advanced disease does not exceed 20%.The aetiology of ovarian cancer temains poorly understood.In China,the major focus of research is to clarify the mechanism underlying ovarian cancer,develop more effective life-saving diagnostic and therapeutic measures,and undertake more population-based studies.This article summarizes current research,diagnosis and management of ovarian cancer in China.
Pancreatic Cancer; Thyroid Cancer; Lung Cancer; Esophageal Cancer; Thymus Cancer; Colon Cancer; Rectal Cancer; GIST; Anal Cancer; Bile Duct Cancer; Duodenal Cancer; Gallbladder Cancer; Gastric Cancer; Liver Cancer; Small Intestine Cancer; Peritoneal Surface Malignancies; Familial Adenomatous Polyposis; Lynch Syndrome; Bladder Cancer; Kidney Cancer; Penile Cancer; Prostate Cancer; Testicular Cancer; Ureter Cancer; Urethral Cancer; Hypopharyngeal Cancer; Laryngeal Cancer; Lip Cancer; Oral Cavity Cancer; Nasopharyngeal Cancer; Oropharyngeal Cancer; Paranasal Sinus Cancer; Nasal Cavity Cancer; Salivary Gland Cancer; Skin Cancer; CNS Tumor; CNS Cancer; Mesothelioma
Research in psycho-oncology investigates the psycho-social and emotional aspects of cancer and how this is related to health, well-being and overall patient care. Coping with cancer is a prime focus for researchers owing to its impact on patients′ psychological processing and life in general. Research so far has focused mainly on quantitative study designs such as questionnaires to examine the coping strategies used by cancer patients. However, in order to gain a rich and deep understanding o...
Cheng, Le; Ramesh, Anirudh V.; Flesken-Nikitin, Andrea; Choi, Jinhyang; Nikitin, Alexander Yu.
Cancer stem cell concept assumes that cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor initiating cells, which are able to reproduce themselves and produce phenotypically heterogeneous cells with lesser tumorigenic potential. Cancer stem cells represent an appealing target for development of more selective and efficient therapies. However, direct testing of the cancer stem cell concept and assessment of its therapeutic implications in human...
Dagmara Jaworska; Wojciech Król; Ewelina Szliszka
Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve th...
Developmental assessment, process-oriented and student-centered, aims at students’performance in learning process, and their development. The author of the paper conducted an empirical research of developmental assessment to her own students. By comparing the students’learning attitude, interest, motivation, strategies, performance and achievements in the experimental class with those in the controlled one, she found that developmental assessment had developed the students’comprehensive lan⁃guage competence, increased their grades in written examinations, especially in the final examination, and recorded their progress over time to have them a sense of accomplishment and become more self-confident, active, responsible and independent. There⁃fore, developmental assessment is an effective and reasonable assessment in the current polytechnic English teaching.
Full Text Available The fuzzy clustering algorithm is to classify the data or indicators with a greater degree of similarity based on the principle of the same type of individuals possessing a greater similarity, and different types of individuals possessing differences, establish clear category boundaries, form any shape of relationship clusters in the solving process, and input the research indicators at random, in order to accurately analyze the significance of the indicators in the algorithm. The evaluation value of the clustering analysis can be obtained by the establishment of the fuzzy factor set based on the membership analysis, and the evaluation result can be analyzed through reference to the evaluation indicators of the fuzzy clustering analysis. The “micro-lecture” English teaching mode can be estimated and the analysis indicators can be rationally established based on the fuzzy clustering analysis algorithm, with better algorithm applicability.
Børresen, Betina; Clausen, Malene Martini; Hansen, Anders Elias; Engelholm, Svend Aage; Kjær, Andreas; Kristensen, Annemarie Thuri; Zornhagen, Kamilla Westarp
Cancer bearing dogs represent a unique clinical cancer model with a direct potential for accelerating translation into human patients. A research collaboration between the veterinary and human medical facilities at Copenhagen University and Rigshospitalet has taken offset in this. Canine cancer...
Full Text Available Research in psycho-oncology investigates the psycho-social and emotional aspects of cancer and how this is related to health, well-being and overall patient care. Coping with cancer is a prime focus for researchers owing to its impact on patients′ psychological processing and life in general. Research so far has focused mainly on quantitative study designs such as questionnaires to examine the coping strategies used by cancer patients. However, in order to gain a rich and deep understanding of the reasons, processes and types of strategies that patients use to deal with cancer, qualitative study designs are necessary. Few studies have used qualitative designs such as semi-structured interviews to explore coping with cancer. The current paper aims to review the suitability and benefits of using qualitative research designs to understand coping with cancer with the help of some key literature in psycho-oncology research.
Hoover, Richard B.; Shealy, David L.; Brinkley, B. R.; Baker, Phillip C.; Barbee, Troy W., Jr.; Walker, Arthur B. C., Jr.
The NASA technology employed during the Stanford MSFC LLNL Rocket X Ray Spectroheliograph flight established that doubly reflecting, normal incidence multilayer optics can be designed, fabricated, and used for high resolution x ray imaging of the Sun. Technology developed as part of the MSFC X Ray Microscope program, showed that high quality, high resolution multilayer x ray imaging microscopes are feasible. Using technology developed at Stanford University and at the DOE Lawrence Livermore National Laboratory (LLNL), Troy W. Barbee, Jr. has fabricated multilayer coatings with near theoretical reflectivities and perfect bandpass matching for a new rocket borne solar observatory, the Multi-Spectral Solar Telescope Array (MSSTA). Advanced Flow Polishing has provided multilayer mirror substrates with sub-angstrom (rms) smoothnesss for the astronomical x ray telescopes and x ray microscopes. The combination of these important technological advancements has paved the way for the development of a Water Window Imaging X Ray Microscope for cancer research.
Gill, Ryan; Datta, Somnath; Datta, Susmita
A complex disease like cancer is hardly caused by one gene or one protein singly. It is usually caused by the perturbation of the network formed by several genes or proteins. In the last decade several research teams have attempted to construct interaction maps of genes and proteins either experimentally or reverse engineer interaction maps using computational techniques. These networks were usually created under a certain condition such as an environmental condition, a particular disease, or a specific tissue type. Lately, however, there has been greater emphasis on finding the differential structure of the existing network topology under a novel condition or disease status to elucidate the perturbation in a biological system. In this review/tutorial article we briefly mention some of the research done in this area; we mainly illustrate the computational/statistical methods developed by our team in recent years for differential network analysis using publicly available gene expression data collected from a well known cancer study. This data includes a group of patients with acute lymphoblastic leukemia and a group with acute myeloid leukemia. In particular, we describe the statistical tests to detect the change in the network topology based on connectivity scores which measure the association or interaction between pairs of genes. The tests under various scores are applied to this data set to perform a differential network analysis on gene expression for human leukemia. We believe that, in the future, differential network analysis will be a standard way to view the changes in gene expression and protein expression data globally and these types of tests could be useful in analyzing the complex differential signatures. PMID:23530503
One of the objectives of English as Lingua Franca (ELF) researchers is an account of the unique features of English that they have found in the speech of European users of English. These features, it is argued, describe a variety of English which they label "English as Lingua Franca". The choice of this particular term is problematic because, as a…
Modern colleges are faced with the dual pressures of university reform and international competition, how to overcome difficulties, to play the role of modern English teaching in colleges and colleges to enhance the core competitiveness of colleges, colleges and colleges modern English teaching problems to be solved. Based on the current situation of modern colleges in the premise of the Modern media platform fully demonstrated the characteristics and viability of the Modern media English tea...
Constructivism is the frontier theory of cognitive psychology,constructivism has important and far-reaching influence to the college English teaching reform which is vigorously implemented in our country.Based on the introduce of constructivism theory,and the analysis of the college English multimedia network teaching status quo in present undergraduate course colleges and universities,this paper put forwards relevant suggestions on how to use constructivism theory in college English multimedia network teaching.
Full Text Available Abstract Background There is a growing amount of literature to support the view that active involvement in research by consumers, especially informed and networked consumers, benefits the quality and direction of research itself, the research process and, most importantly, people affected by cancer. Our exploratory project focuses on identifying their priorities and developing a process to assess the research needs of Australian cancer consumers which may be useful beyond the cancer scenario. Methods This project was consumer initiated, developed and implemented, with the assistance of a leading Australian cancer consumer advocacy group, Cancer Voices NSW (CVN. Such direct involvement is unusual and ensures that the priorities identified, and the process itself, are not influenced by other interests, regardless how well-intentioned they may be. The processes established, and data collection via a workshop, followed by a questionnaire to confirm and prioritise findings, and comparison with a similar UK exercise, are detailed in this paper. Results Needs across five topic areas reflecting cancer control domains (prevention and risk; screening and diagnosis; treatment; survivorship; and end of life were identified. Cancer consumers high priority research needs were found to be: earlier diagnosis of metastatic cancers; the extent of use of best practice palliative care guidelines; identifying barriers to cancer risk behaviour change; and environmental, nutrition and lifestyle risk factors for people with cancer. A process for identifying consumers’ research priorities was developed and applied; this may be useful for further investigation in this under-studied area. Conclusion The findings provide a model for developing a consumer derived research agenda in Australia which can be used to inform the strategic direction of cancer research. Consumers have been seeking a workable method to achieve this and have worked in collaboration with a major
Butler, Yuko Goto
The teaching of foreign languages to young learners is growing in popularity around the world. Research in this field, particularly of English as a second/foreign language education in East Asia, is a relatively new area of empirical inquiry, and it has the potential to make significant contributions to child second-language acquisition…
Nash, Ian; Jones, Sue
This research by the Boston Consulting Group (BCG) for Sutton Trust examined the English education system and its apprenticeship programs. BCG reported that the UK is failing nearly half its young people by providing inadequate vocational opportunities. BSG presents key findings that include: (1) more than four in ten people have only low level…
The notion that academic writing is not only a conventional entity but also carries the representation of the writer has been supported by several researchers. Few studies have explored identity representation in language across two written cultures, such as English and Spanish, although Spanish might be a language of interest for non-native…
Li, Li-Juan; Ge, Guang-Chun
This paper reports a corpus-based genre analysis of the structural and linguistic evolution of medical research articles (RAs) written in English. Towards that end, we analyzed the frequency of occurrence of the 11 moves identified by Nwogu (1997), of the three most frequently used verb tenses (simple past, simple present and present perfect) and…
This paper presents an empirical study of move structures and personal pronouns of fifty English RA (research article) abstracts based on the model of Bhatia (1990). It revealed that three other move patterns were ascertained besides ten out of the analyzed abstracts following his move order. The analysis of personal pronouns showed that…
The impact of globalisation in the last 20 years has led to an overwhelming increase in the use of English as the medium through which many business people get their work done. As a result, the linguistic landscape within which we now operate as researchers and teachers has changed both rapidly and beyond all recognition. In the discussion below,…
This paper is a generic study of schematic structures and the use of modal verbs of 50 English Research Article (RA) abstracts. With Bhatia's (1990) model as the framework, three other move patterns were obtained besides the normal move order. The density of modal verbs varies greatly from move to move with significant differences in the frequency…
Rubdy, Rani; Tupas, T. Ruanni F.; Villareal, Corazon D.; David, Maya Khemlani; Dumanig, Francisco Perlas
This review highlights recent doctoral research in English language education and related areas completed between 2007 and 2010 in three countries in Southeast Asia: Singapore, Malaysia and the Philippines. Out of sixty dissertations initially chosen from major universities in these countries, five from the Philippines, four from Malaysia and…
China English does exist, which is reconfirmed by salient linguistic features illustrated and documented by many research scholars. This paper explores some pedagogical implications addressing the issue of integrating China English into college English teaching to enhance learners' confidence and competence in cross-cultural communication.
Shyr, Derek; Liu, Qi
The wide application of next-generation sequencing (NGS), mainly through whole genome, exome and transcriptome sequencing, provides a high-resolution and global view of the cancer genome. Coupled with powerful bioinformatics tools, NGS promises to revolutionize cancer research, diagnosis and therapy. In this paper, we review the recent advances in NGS-based cancer genomic research as well as clinical application, summarize the current integrative oncogenomic projects, resources and computatio...
Correa-Fernández, Virmarie; Davila, Marivel; Kamrudin, Samira A.; Li, Dennis H.; Noor, Syed W.; Oluyomi, Abiodun O; Chang, Shine; Cameron, Carrie
To increase the adoption of transdisciplinary research methods among future cancer prevention investigators, faculty members from The University of Texas MD Anderson Cancer Center developed a graduate-level course in biobehavioral methods in cancer prevention research. Two instructors paired by topic and area of expertise offered an hour-long lecture-based seminar every week for 15 weeks during the spring semester of 2010. Students and presenters both evaluated the overall course content and ...
Full Text Available Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve the prognosis for patients with advanced stages of the disease.
Winkels, Renate M; van Lee, Linde; Beijer, Sandra; Bours, Martijn J; van Duijnhoven, Fränzel J B; Geelen, Anouk; Hoedjes, Meeke; Mols, F.; de Vries, Jeanne; Weijenberg, Matty P; Kampman, Ellen
We examined adherence to the eight The World Cancer Research Foundation/American Institute for Cancer Research (WCRF/AICR) recommendations on diet, physical activity, and body weight among colorectal cancer survivors, and whether adherence was associated with intention to eat healthy and with the ne
... understanding affect how we think about cancer and cancer research? What we've learned can be grouped into ... some of the opportunities that you see in cancer research? The National Cancer Institute is ready to take ...
The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health, and the US Department of Agriculture's Beltsville Human Nutrition Research Center are offering a one week educational opportunity in "Nutrition and Cancer Prevention Research" for individuals with a sustained commitment to nutrition and health promotion. |
Prostate cancer is a common malignant tumor in male urinary system,and may easily develop into the hormone refractory prostate cancer which can hardly be cured. Recent studies had found that the prostate cancer stem cells may be the source of the prostate cancer's occurrence,development, metastasis and recurrence. The therapy targeting the prostate cancer stem cells may be the effective way to cure prostate cancer. But these cells is too low to be detected. The difficulty lies in the low separation efficiency of prostate cancer stem cell, so the effectively separating prostate cancer stem cells occupied the main position for the more in-depth research of prostate cancer stem cells. This paper reviews the research progress and existing problems on the several main separating methods of prostate cancer stem cells, includes the fluorescence activated cells sorting and magnetic activated cells sorting based on prostate cancer stem cell surface markers, the side-population sorting and serum-free medium sphere forming sorting based on prostate cancer stem cell's biology. (authors)
Becker, Thomas M.; Dunn, Esther; Tom-Orme, Lillian; Joe, Jennie
Several social and biological scientists who have Native status are engaged in productive research careers, but the encouragement that has been offered to Native students to formulate career goals devoted to cancer etiology or cancer control in Native peoples has had limited success. Hence, the Native Researchers' Cancer Control Training Program…
Although English teachers have implicitly been aware of the functions of writing, they may not always have explored the ways writing can be used to enhance learning: learning of content, of skills, and of self. Arthur Applebee noted that English teachers were most likely to stress personal and imaginative experiences in their writing assignments,…
Jin, Jie; Liu, Hengying; Zhang, Yan
Increased universities and colleges offer the undergraduates with more follow-up courses with the further reform in college English education in China. An investigation on self-evaluation, difficulty, and willingness of undergraduates in learning English further was made in order to design more appropriate and adaptable follow-up courses. This…
This paper mainly centers on the neglecting parts of English intermediates in middle school and presents their existing study problems. According to intermediates' characters and learning motivation, I will reveal reasons of these problems and come up with effective strategies from two aspects of English teachers and students.
With China's opening up and joining the World Trade Organization, more and more people are learning English. English study is very important for the learners, which involves a lot of factors, among which the learner's own factor is the most direct and main factor. In English teaching, we shouldn’t just pay our attention to the regular teaching principle of teaching stu-dents in accordance with their aptitude, and turn a blind eye to the non-intellectual factors of the learners. This thesis analyzes the differences and their reasons, and then puts forward some relevant countermeasures for eliminating the differences in English learning between boys and girls, in the hope of promoting them to make progress together in English study.
McWhirter, Jennifer; Todd, Laura; Hoffman-Goetz, Laurie
The Short Test of Functional Health Literacy for Adults (S-TOFHLA) and Cloze test are commonly used tools to measure comprehension of health information (i.e., health literacy); however, little is known about their use in English-as-a-Second-Language (ESL) populations. In this study, we compared written (Cloze test) and oral (Teach Back) measures of colon cancer information comprehension among ESL Chinese immigrant women to Canada. Performances on colon cancer-specific measures were compared to a general measure of health literacy (S-TOFHLA). On the S-TOFHLA, Cloze, and Teach Back, respectively, the following percentage of participants had adequate comprehension: 62.1%, 14.8%, and 89.7%. Correlation between performance on the Cloze and Teach Back was significant albeit weakly so (r = 0.38, p = 0.04); performances on the S-TOFHLA and Teach Back were not correlated. Measures of health literacy skill that require written English language skills may not be appropriate for measuring understanding of health information for ESL populations. PMID:21445682
Irrigated water meadows are found across Europe, from southern Scandinavia to Spain and in the Alpine regions and Italy. While the practice of engineering 'floated' meadow land for deliberate irrigation on hillsides and floodplains is widespread and ancient, since about 1600 AD the practice was widely adopted on floodplains in southern England where they improved the timing and productivity of grazing land and produced hay crops. They also became a part of English consciousness through art and literature. To some, water meadows are a relic of an agrarian past, to others they are the object of a range of foci for conservation, education, sustainable grass production, community engagement and recent research suggests water returned from meadow irrigation is beneficial to river water quality. Historically floodplain 'bedwork' water meadows grew from, and were integral in, the farming system of 'Wessex' involving sheep which produced dung for arable land and later supporting dairy and beef production, as well as hay. Where systems remain, this is largely due to the whim of individuals, the outcome of agri-environmental schemes. Water meadows may be managed by public, voluntary or private sector bodies. What is needed is a fresh look at how land owners, or communities, might micro-target them for heritage, habitat and grassland management. There are therefore interesting questions concerning their future: Who might invest in their restoration and maintenance? How might they be integrated into commercial farming? Are they of sufficient interest to restore en masse to become (once more) a major feature of the English chalk stream valleys? Do they provide a way into academic and public perception, combining environmental science, history, cultural heritage and environmental management? How might restoration and management become vehicles for public engagement? While each of these questions represents a major topic for discussion, this paper is an attempt to consolidate
The United States National Cancer Institute (NCI) supports complementary and alternative medicine (CAM) research which includes different methods and practices (such as nutrition therapies) and other medical systems (such as Chinese medicine). In recent years, NCI has spent around $120 million each year on various CAM-related research projects on cancer prevention, treatment, symptom/side effect management and epidemiology. The categories of CAM research involved include nutritional therapeutics, pharmacological and biological treatments, mind-body interventions, manipulative and body based methods, alternative medical systems, exercise therapies, spiritual therapies and energy therapies on a range of types of cancer. The NCI Office of Cancer Complementary and Alternative Medicine (OCCAM) supports various intramural and extramural cancer CAM research projects. Examples of these cancer CAM projects are presented and discussed. In addition, OCCAM also supports international research projects. PMID:22241505
Although Bangladesh is largely monolingual, English is increasingly important for international communication. The English in Action project was established to enhance the use of English as a tool for better access to the world economy. Interventions in three sectors (primary education, secondary education and adult learning) aim to improve the teaching and learning of communicative English over a 9-year period. At the outset of the project a range of baseline studies was undertaken to collec...
Agarwal, Pankaj; Owzar, Kouros
Advances in next generation sequencing (NGS) and mass spectrometry (MS) technologies have provided many new opportunities and angles for extending the scope of translational cancer research while creating tremendous challenges in data management and analysis. The resulting informatics challenge is invariably not amenable to the use of traditional computing models. Recent advances in scalable computing and associated infrastructure, particularly distributed computing for Big Data, can provide solutions for addressing these challenges. In this review, the next generation of distributed computing technologies that can address these informatics problems is described from the perspective of three key components of a computational platform, namely computing, data storage and management, and networking. A broad overview of scalable computing is provided to set the context for a detailed description of Hadoop, a technology that is being rapidly adopted for large-scale distributed computing. A proof-of-concept Hadoop cluster, set up for performance benchmarking of NGS read alignment, is described as an example of how to work with Hadoop. Finally, Hadoop is compared with a number of other current technologies for distributed computing. PMID:25983539
Celis, Julio E; Moreira, José M A; Gromova, Irina;
, promise to have a major impact on the way breast cancer will be diagnosed, treated and monitored in the future. Here we present a brief report on long-term ongoing strategies at the Danish Centre for Translational Breast Cancer Research to search for markers for early detection and targets for therapeutic......Discovery-driven translational research in breast cancer is moving steadily from the study of cell lines to the analysis of clinically relevant samples that, together with the ever increasing number of novel and powerful technologies available within genomics, proteomics and functional genomics...... biology approach to fight breast cancer....
This past July, I started a journey into the fields of communications and cancer research when I joined the Office of Cancer Genomics (OCG) as a fellow in the National Cancer Institute (NCI) Health Communications Internship Program (HCIP). Cancer genomics and working in an office were new and uncharted territory for me: before I came to OCG, I was finishing a Ph.D. in cell biology at Vanderbilt University in Dr. Matthew Tyska’s laboratory.
"Cancer is a disease of the genome," noted Lynda Chin, M.D., professor of dermatology, Harvard Medical School and Dana-Farber Cancer Institute. "And understanding the impact of genomic changes in the proteome is critically important for converting genomic knowledge into something that a clinician can use on their patients."
In traditional English class of China, the relationship between teacher and students is one-way communication. As a result, positive attendance in senior English class is not common. It is important to develop students' automatic learning and coop⁃eration learning abilities. However, the particularities of senior students in psychology and the background of college entrance ex⁃amination block the way of traditional teaching reform. From these aspects, this thesis comes up with corresponding advices to promote the attendance of senior English class.
Radiotherapy has a proven potential to eradicate cancer stem cells which is reflected by its curative potential in many cancer types. Considerable progress has been made in identification and biological characterisation of cancer stem cells during the past years. Recent biological findings indicate significant inter- and intratumoural and functional heterogeneity of cancer stem cells and lead to more complex models which have potential implications for radiobiology and radiotherapy. Clinical evidence is emerging that biomarkers of cancer stem cells may be prognostic for the outcome of radiotherapy in some tumour entities. Perspectives of cancer stem cell based research for radiotherapy reviewed here include their radioresistance compared to the mass of non-cancer stem cells which form the bulk of all tumour cells, implications for image- and non-image based predictive bio-assays of the outcome of radiotherapy and a combination of novel systemic treatments with radiotherapy
Along with the Lung Cancer Social Media (#LCSM) community, the National Cancer Institute will be co-hosting a lively and interactive Google Hangout on Air about the changing landscape of lung cancer research and treatment. During the chat, viewers will have the opportunity to pose questions to a panel of lung cancer experts including NCI's Dr. Shakun Malik, the head of thoracic oncology therapeutics, Roy S. Herbst, MD, PhD, Chief of Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven and David Tom Cooke MD FACS, Head, Section of General Thoracic Surgery University of California, Davis. You can also learn more and follow along on the #LCSM Chat page. The chat will be moderated by lung cancer advocate and #LCSM co-founder, Janet Freeman-Daily. To ask questions of our experts, simply use the #LCSM hashtag during the chat.
Zhu, Fei; Patumcharoenpol, Preecha; Zhang, Cheng; Yang, Yang; Chan, Jonathan; Meechai, Asawin; Vongsangnak, Wanwipa; Shen, Bairong
Cancer is a malignant disease that has caused millions of human deaths. Its study has a long history of well over 100years. There have been an enormous number of publications on cancer research. This integrated but unstructured biomedical text is of great value for cancer diagnostics, treatment, and prevention. The immense body and rapid growth of biomedical text on cancer has led to the appearance of a large number of text mining techniques aimed at extracting novel knowledge from scientific text. Biomedical text mining on cancer research is computationally automatic and high-throughput in nature. However, it is error-prone due to the complexity of natural language processing. In this review, we introduce the basic concepts underlying text mining and examine some frequently used algorithms, tools, and data sets, as well as assessing how much these algorithms have been utilized. We then discuss the current state-of-the-art text mining applications in cancer research and we also provide some resources for cancer text mining. With the development of systems biology, researchers tend to understand complex biomedical systems from a systems biology viewpoint. Thus, the full utilization of text mining to facilitate cancer systems biology research is fast becoming a major concern. To address this issue, we describe the general workflow of text mining in cancer systems biology and each phase of the workflow. We hope that this review can (i) provide a useful overview of the current work of this field; (ii) help researchers to choose text mining tools and datasets; and (iii) highlight how to apply text mining to assist cancer systems biology research. PMID:23159498
Prentice, Ross L.
The potential for a reduction in dietary fat or for an increase in dietary fiber to reduce breast cancer risk has been debated for some years. It is argued here that available research data, even though extensive, leave open hypotheses ranging from little or no potential to major public health potential for breast cancer prevention by means of these dietary maneuvers. Some elements of a research strategy for testing these and other dietary breast cancer prevention hypotheses are described.
Coughlin, Steven S; Thind, Herpreet; Liu, Benyuan; Wilson, Lt Col Candy
Efforts to prevent breast cancer and other chronic illnesses have focused on promoting physical activity, healthy diet and nutrition, and avoidance of excessive alcohol consumption. Smartphone applications (apps) offer a low-cost, effective strategy for breast cancer prevention in women through behavioral change. However, there are currently no research-tested smartphone apps for breast cancer prevention that are suitable for women with varying levels of health literacy and eHealth literacy. ...
Full Text Available Lung cancer treatment has altered from conventional chemotherapy to targeted treatment, which now has been turned to the immunotherapy. Translational research has played an irreplaceable role during this progression which graphic evolution has witnessed. The evolution has gone through forest plot, KM-curve, waterfall plot, spider plot and timeline-area, showing us the refining concept and gradual process of lung cancer treatment undergoing from community towards individual. Even though the latest immunotherapy is getting increasingly hot, the result isn’t quite expected. Meanwhile, the limitations of conventional treatment still exist which require further research. This article will primarily illustrate the development of translational research of lung cancer via the aspect of curve evolution and analysis some abortive clinical trials in lung cancer surgery for inspiring the next graphic style and lung cancer treatment.
Zhang, Chao; Zhong, Wenzhao
Lung cancer treatment has altered from conventional chemotherapy to targeted treatment, which now has been turned to the immunotherapy. Translational research has played an irreplaceable role during this progression which graphic evolution has witnessed. The evolution has gone through forest plot, KM-curve, waterfall plot, spider plot and timeline-area, showing us the refining concept and gradual process of lung cancer treatment undergoing from community towards individual. Even though the latest immunotherapy is getting increasingly hot, the result isn't quite expected. Meanwhile, the limitations of conventional treatment still exist which require further research. This article will primarily illustrate the development of translational research of lung cancer via the aspect of curve evolution and analysis some abortive clinical trials in lung cancer surgery for inspiring the next graphic style and lung cancer treatment. PMID:27335306
With the arrival of the new millennium,the demand fortalented people with both professional knowledge and excellentlanguage abilities is getting stronger and stronger.For business major students,reading is paramount inBusiness English teaching and learning.And their reading abilityis often assessed by a text of reading comprehension.However,from my experience as a college teacher ofBusiness English,I have noticed some problems among studentswho have little knowledge of business.They seem to readBusiness English materials at a slower rate and with lessunderstanding than general English materials.Then there is the question:is Business English reading"simply"a problem of language competence? Or are there anyother more important factors?This article is an investigation into the effect of backgroundknowledge on Business English reading comprehension.Thestudy attempts to assess to what extent L2 readers might beaffected because of their lack of a background schematapresupposed by the author by comparing the test results of twopassages comparable in language lightness or heaviness.Morecomparable passages like these can be used in investigating intothe rival effects of background knowledge and linguisticcompetence.The implications of comprehension theory for L2pedagogy are discussed and suggestions for Business Englishteaching is put forward.
Southward, Alan J; Langmead, Olivia; Hardman-Mountford, Nicholas J; Aiken, James; Boalch, Gerald T; Dando, Paul R; Genner, Martin J; Joint, Ian; Kendall, Michael A; Halliday, Nicholas C; Harris, Roger P; Leaper, Rebecca; Mieszkowska, Nova; Pingree, Robin D; Richardson, Anthony J; Sims, David W; Smith, Tania; Walne, Anthony W; Hawkins, Stephen J
Long-term research in the western English Channel, undertaken by the marine laboratories in Plymouth, is described and details of survey methods, sites, and time series given in this chapter. Major findings are summarized and their limitations outlined. Current research, with recent reestablishment and expansion of many sampling programmes, is presented, and possible future approaches are indicated. These unique long-term data sets provide an environmental baseline for predicting complex ecological responses to local, regional, and global environmental change. Between 1888 and the present, investigations have been carried out into the physical, chemical, and biological components (ranging from plankton and fish to benthic and intertidal assemblages) of the western English Channel ecosystem. The Marine Biological Association of the United Kingdom has performed the main body of these observations. More recent contributions come from the Continuous Plankton Recorder Survey, now the Sir Alister Hardy Foundation for Ocean Science, dating from 1957; the Institute for Marine Environmental Research, from 1974 to 1987; and the Plymouth Marine Laboratory, which was formed by amalgamation of the Institute for Marine Environmental Research and part of the Marine Biological Association, from 1988. Together, these contributions constitute a unique data series-one of the longest and most comprehensive samplings of environmental and marine biological variables in the world. Since the termination of many of these time series in 1987-1988 during a reorganisation of UK marine research, there has been a resurgence of interest in long-term environmental change. Many programmes have been restarted and expanded with support from several agencies. The observations span significant periods of warming (1921-1961; 1985-present) and cooling (1962-1980). During these periods of change, the abundance of key species underwent dramatic shifts. The first period of warming saw changes in
The sessions in the 2. Research Conference 'Thyroid cancer 2000' concerned molecular biology, epidemiology, pathology, advances in diagnosis and therapy of thyroid cancer. Some communications discussed molecular, biological and environmental risk factors (ionizing radiation, iodine deficiency). Radiobiological, dosimetric and radiological protection problems connected with iodine-131 therapy have been presented and discussed
Data concerning the psychological impact of high risk of cancer are reviewed, including implications of genetic testing, breast screening,and accuracy of women's risk estimates. Work in progress on prophylactic mastectomy and chemoprevention is reviewed. Research on cancer families, and interventions and prevention strategies for high-risk…
The purpose of this notice is to notify the community that the National Cancer Institute's (NCI’s) Office of Cancer Clinical Proteomics Research (OCCPR) is seeking sources to establish a Biospecimen Core Resource (BCR), capable of receiving, qualifying, processing, and distributing annotated biospecimens.
The NCI Community Oncology Research Program (NCORP) is a national network of cancer care investigators, providers, academia, and other organizations that care for diverse populations in health systems. View the list of publications from NCORP. | Clinical Trials network of cancer care professionals who care for diverse populations across the U.S.
It has been reported that environmental chemicals are important factors in terms of both development and prevention of human cancer. For prevention of human cancer, detection of early cancer and clinical trials at the early stage have been focused so far. Now, next main project will be investigation for prevention of cancer development itself. Chemoprevention of carcinogenesis, which means prevention of carcinogenesis by some chemical compounds, have been investigated extensively in a variety of organs, but in only one organ. However, from results of our studies, antioxidants such as BHA, responded differently to organs, and whole body investigation, not only one organ carcinogenesis, should be performed to investigate of chemoprevention. Furthermore, the mechanisms of action of chemoprevention and on which step of carcinogenesis does the chemopreventive compound prevent, such as initiation, promotion, progression or whole carcinogenesis steps should be discussed. We have developed a medium term bioassay system and multi-organ carcinogenesis system, which can be used for investigation of cancer chemoprevention. Using these systems, we have investigated dose response inhibitory effects of BHA and α-tocopherol by the medium-term bioassay system, and catechins in the green tea inhibit small intestinal carcinogenesis in the multi-organ carcinogenesis. It is important for prevent human cancer to find other candidates for chemopreventive agents using animal study. (author)
In this article the writer surveys attitudes to the integration of language and literature in ESL/EFL teaching, noting the reservations that have been expressed about it in the past, and which still continue to linger in some quarters. Against this background he then describes the development and implementation of an integrated English syllabus at the University of North West, focusing on his current action research in teaching the first year modules. Using examples from the material he has d...
The total number of malignant neoplasms included on this study 7,787 cases(10.4%) among 74,928 cases for 2 years. On sex, females with 57.6% were much more than males with 42.4%. The highest proportion of cancer 50-59 age group. The most frequent primary site among males was found to be stomach with 36.2%, followed by liver(12.3%), lung(12.2%), esophagus(15.5%) and larynx(4.9%). In females, the first order was uterine cervix with 47.3%, followed most common type of morphology of malignant neoplasms was adenocarcinoma(39.0%) in males an squamous cell carcinoma(56.2%) in females. Among the cancer patients initially diagnosed in this hospital, the proportion of malignant neoplasms by the extent of disease was 4.6% for patient with carcinoma-in-situ, 76.3% for patients with localized involvement, 11.6% for patients with regional involvement and 7.5% for patients with distant involvement. Among,the cancer patients initially treatment in this hospital, the proportion of malignant neoplasms by the method of treatment was 19.0% for surgery, 27.7 for radiotherapy and 24.2% for chemotherapy. Among the cancer patients confirmed by medical records, 11.2% was traced more than 5 years. (Author)
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Researches on English homework in primary and secondary school in China mainly involve five parts: quantity and time of English homework, function of English homework, content and types of English homework, optimal strategies of English homework design, evaluation and feedback of English homework. These researches are a positive inspiration and provide a good reference for the study of English teaching in primary and secondary school. However, there still exist many problems in these studies. For example, there are more researches focusing on speciifc issues, but the researches and construc tion of basic theory of homework are not enough; there are more experience summary and theorefical researches, but quantitative reseaches are not enough.%国内对中小学英语家庭作业的研究涉及英语家庭作业的量、时间、功能、内容与类型、优化设计与布置和评价与反馈等研究。这些研究对中小学英语教学有积极的启发和借鉴意义，但也存在对具体问题的研究较多，对作业基本理论的研究和建构薄弱；经验总结和思辨研究多，量化研究少的问题。
With the rapid development of the society, people are expected to improve their language quality as well. So when people have to express something unpleasant, they prefer to employ some mild, implicit and euphemistic expressions. Meanwhile, an increasing number of scientists indulge themselves in studying English euphemisms from different perspectives, such as linguis⁃tics, pragmatics, and psychology and so on. English Euphemisms applied in class can not only help create a relaxing and lively at⁃mosphere but also protect the students’self-esteem and stimulate their interests in English. However, the researches on the ef⁃fects of applying English euphemisms in English class are few. Therefore, Based on Face-saving Theory, this paper intends to highlight the importance of applying English euphemisms in English teaching.
Franco, Idalid; Bailey, LeeAnn O.; Bakos, Alexis D.; Springfield, Sanya A.
Mentoring is a critical aspect of research and training; and the adoption of a successful mentoring model for guiding researchers through the educational pipeline is lacking. The Continuing Umbrella of Research Experiences (CURE) program was established in the Comprehensive Minority Biomedical Branch; which is part of the National Cancer Institute. This program offers unique training and career development opportunities to enhance diversity in cancer research. The CURE initiative focuses on b...
Full Text Available Metastatic and recurrent tumors have been identified as the leading attribute to the lung cancer deaths. Cancer research has demonstrated the critical role circulating tumor cells (CTCs play in the metastatic spread of carcinomas and the recurrence of lung cancer. The rapid advancement of technology in targeted therapy resolves the embarrassing situation for those late-stage patients whose tumor tissues cannot be obtained. CTCs, as a substitute for the tumor tissues, represent a decisive tool to the cancer treatment strategy. Thus, CTCs exert a fundamental role in the early detection of micro-metastasis, assisting in diagnosis, prognosis and monitoring of the recurrent tumors, and subsequently choosing an individualized approach for the therapeutic treatment. This article will review the advances, which have been made in the research area of CTCs with the aid of its applications in cancer therapy.
Adebamowo, C A; Akarolo-Anthony, S
Cancer is a worldwide public health problem causing increasing morbidity and mortality, particularly in the developing world. Underlying trends are changing the pattern of cancer and this is also being influenced by the HIV/AIDS pandemic, particularly in Sub-Saharan Africa. Even though the pattern of cancer varies across Africa, there are identifiable trends. Breast and cervical cancers, and Kaposi sarcoma are the commonest cancers in women, while Kaposi sarcoma, liver and prostate cancers are the commonest in men. Cancer causes more morbidity and mortality in Africa compared to other parts of the world. Infections account for a disproportionate amount of cancers in Africa. The HIV epidemic is contributing to increased prevalence of many cancers particularly those associated with Herpes and Papilloma viruses. Tobacco use, another major carcinogen, is increasing, particularly among the young. Dietary factors, alcohol use, physical inactivity and environmental pollution are also important aetiological factors of cancer in Africa. In developing countries, poverty, limited government health budget and poor health care systems complicate cancer prevention, treatment and outcomes. Coordinated response by international agencies and NGOs is needed to help developing countries and several successful models exist. More action is also needed on ensuring safety and quality of chemotherapy and the price needs to be reduced. Responses advocated for cancer control in Africa include banning tobacco use, better regulation of alcohol sale, better environmental planning and immunization against cancer associated viruses. Training of health care workers to diagnose cancer and treat it effectively within limited budgets is needed. Research to develop these new treatments and others, particularly from natural products is urgently needed and this can be done safely within established health research ethics regulatory frameworks. Several opportunities for collaborative research and