canada genetic implications: Topics by WorldWideScience.org

Population genetic structure of savannah elephants in Kenya: conservation and management implications

BackgroundWith a growing number of genetic tests becoming available to the health and consumer markets, genetic health care providers in Canada are faced with the challenge of developing...Full Text Available

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Allozyme Divergence in Two Syntopic Liolaemus of the Liolaemus monticola Group (Squamata: Tropiduridae)

Udgivelsesdato: null-null

2008-01-01

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The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics

... shareware for population genetic analysis. Molecular Biology and Biotecnology Centre, Univ. of Alberta, Canada. enlarge figure Fig. ... ...

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Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens

Mouse genetic resources include inbred strains, recombinant inbred lines, chromosome substitution strains, heterogeneous stocks, and the Collaborative Cross (CC). These resources were generated through...Full Text Available

2007-07-01

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MARINE INFLUENCE IN THE UPPER ORDOVICIAN JUNIATA FORMATION (POTTERS MILLS, PENNSYLVANIA): IMPLICATIONS FOR THE HISTORY ...

The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered....Full Text Available

2009-03-01

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Vegetation response to climate change : implications for Canada's conservation lands

... on a transgressive surface; examples from the Silurian Whirlpool Sandstone of southern Ontario, Canada. Journal of Sedimentary ... and C. J. Salas. 1991. The Lower Silurian Whirlpool Sandstone. in Cheel, ...

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Environmental implications of coal gasification/liquefaction technologies in Canada

Studies have shown that Canada's national parks are vulnerable to the impacts of climate change. A wide range of biophysical climate change impacts could affect the integrity of conservation lands in each region of Canada. This report examines the potential impact of climate change on landscape alterations and vegetation distribution in Canada's wide network of conservation lands. It also presents several ways to integrate climate change into existing conservation policy and adaptation strategies. Canada's conservation lands include provincial parks, migratory bird sanctuaries, national wildlife areas and wildlife protected areas. This is the first study to examine biome changes by applying an equilibrium Global Vegetation Model (GVM) to Canada's network of national park systems. Some of the policy and planning challenges posed by changes in ...

2003-05-01

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Tumour-stromal interactions: Phenotypic and genetic alterations in mammary stroma - implications for tumour progression

This report reviews coal conversion processes which may be introduced in Canada within the next decade if interest in alternate energy technologies continues. A detailed review was conducted on coal liquefaction and gasification projects worldwide including information on individual proprietors, process technologies used, their present status and available environmental data. Further assessment of emissions and wastes emanating from commercial-scale plants was used to determine significant or potentially significant wastestreams connected to the various technologies, particularly wastewater discharges. Emphasis was placed on those technologies that are close to commercialization in Canada, i.e. SASOL II-type liquefaction facility at Hat Creek. Available information on wastewater treatment/reuse is also included in this report.

1983-01-01

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Relationship between mRNA secondary structure and sequence variability in Chloroplast genes: possible life history implications

In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in...Full Text Available

2001-01-01

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Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

BackgroundSynonymous sites are freer to vary because of redundancy in genetic code. Messenger RNA secondary structure restricts this freedom, as revealed by previous findings in...Full Text Available

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Genetic Diversity in Blastomyces dermatitidis: Implications for PCR Detection in Clinical and Environmental Samples

Human longevity is in part genetically determined, and the insulin/IGF-1 signal transduction (IIS) pathway has consistently been implicated. In humans, type 2 diabetes is a frequent disease that results...Full Text Available

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Biodiversity of Costa Rican salamanders: Implications of high levels of genetic differentiation and phylogeographic structure for species formation

SummaryBlastomycosis is a serious and potentially fatal infection by the thermally dimorphic fungus Blastomyces dermatitidis. PCR assays targeting the BAD-1 virulence...Full Text Available

2010-03-01

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Evidence for Epigenetic Interactions for Loci on Mouse Chromosome 1 Regulating Open Field Activity

Although salamanders are characteristic amphibians in Holarctic temperate habitats, in tropical regions they have diversified evolutionarily only in tropical America. An adaptive radiation centered...Full Text Available

2000-02-15

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British Library Electronic Table of Contents (United Kingdom)

The expression of motor activity levels in response to novel situations is under complex genetic and environmental control. Several genetic loci have been implicated in the regulation of this behavioral phenotype, but their relationship to epigenetic and epistatic interactions is relatively unknown. Here, we report on a quantitative trait locus (QTL) on mouse chromosome 1 for novelty-induced motor activity in the open field, using chromosome substitution strains derived from a high active host strain (C57BL/6J) and a low active donor strain (A/J). The QTL for open field (horizontal distance moved) peaked at the location of Kcnj9, however, QTL detection was initially masked by an interplay of both grandparent genetic origin and genetic co-factors influencing behavior on chromosome 1. Our fi...

2009-01-01

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Canadian R&D on oil-fired combustion systems

Introduction to Genetic Algorithms

This paper describes research and development presently being conducted on oil-fired space and tap water heating systems by the Advanced Combustion Technology Group, CCRL/ERL/CANMET, in Ottawa, Canada. The presentation will focus on R&D activities at CCRL in support of the Canadian Oil Heat Association (COHA) and of the energy policy initiatives of Natural Resources Canada. Progress will be reported on activities to develop suitable oil-fired integrated systems to satisfy the low energy demands of new homes. The utilization of fuzzy logic-based control heating systems including fan coils for a complete range of old and new North American housing will be discussed. Additional activities to be discussed in the presentation will relate to the development of appropriate seasonal efficiency standards for complex integrated space/water heating systems, as well as an evaluation of alternative sidewall venting technologies and their ...

1996-07-01

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CERN Document Server

Introduction to Genetic Algorithms

2007-01-01

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Environmental sciences and applications. Volume 4. Strategy for the ozone layer

Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy

A synthesis of papers based on the United Nations Environment Programme meeting on the ozone layer, Washington DC, this book contains valuable information on ongoing and planned activities concerned with stratospheric ozone problems, and presents the recommendations for further action resulting from the meeting. Possible changes in the characteristics of the ozone layer are discussed, together with the environmental, ecological, climatic, economic, and health implications of stratospheric ozone depletion. A comprehensive survey of current research in five European countries, the USA, Canada, and Australia is included and the volume is concluded by the UNEP report of the meeting and a world plan of action.

1980-01-01

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Cuckoo Search via Levy Flights

PlGF, one of the ligands for VEGFR-1, has been implicated in tumor angiogenesis. However, more recent studies indicate that genetic or pharmacological inhibition of PlGF signaling does not result in...Full Text Available

2011-07-12

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CERN Document Server

In this paper, we intend to formulate a new metaheuristic algorithm, called Cuckoo Search (CS), for solving optimization problems. This algorithm is based on the obligate brood parasitic behaviour of some cuckoo species in combination with the Levy flight behaviour of some birds and fruit flies. We validate the proposed algorithm against test functions and then compare its performance with those of genetic algorithms and particle swarm optimization. Finally, we discuss the implication of the results and suggestion for further research.

2010-01-01

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Research and development activities on high efficiency separation process technologies for carbon dioxide removal from industrial sources at University of Regina, Canada

Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?

This paper describes research and development activities at the University of Regina, Saskatchewan, Canada on Optimization of CO{sub 2} Extraction Process Technologies. The ultimate goal of this research is to develop better and more effective CO{sub 2} separation processes which can be used to recover CO{sub 2} from industrial sources such as coal-fired power plants and coal gasification complexes at the lowest possible capital and operating costs. The research program has been supported by Saskatchewan Power Corporation, Saskatchewan Energy and Mines, Prairie Coal Ltd., the Canada Centre for Mineral and Energy Technology (CANMET), Fluor Daniel Inc. (USA), Sulzer Chemtech (Switzerland), Wascana Energy Inc., and Natural Sciences and Engineering Research Council of Canada (NSERC). Currently, six parallel and complementary projects have been carried out at the Process Systems Laboratory. These projects are: (1) Searching for ...

1996-05-01

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British Library Electronic Table of Contents (United Kingdom)

Alzheimer's disease (AD) is the most common form of neurodegenerative disease. The vast majority cases of AD are sporadic, without clear cause, and a combination of environmental and genetic factors has been implicated. The hypothesis that homocysteine (Hcy) is a risk factor for AD was initially prompted by the observation that patients with histologically confirmed AD had higher plasma levels of Hcy, termed hyperhomocysteinemia (HHcy), than age-matched controls. Most evidence accumulated so far implicates HHcy as a risk factor for AD onset, but there are also conflicting results. In this review we summarize reports on the relationship between HHcy and AD from epidemiological investigations, including observational studies and randomized controlled clinical trials. We also examine recent i...

2011-01-01

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White Rose development plan amendment production volume increase

Pop : Phonophani "Genetic Engineering" / Erkki Luuk

In January 2001, Husky Oil Operations Limited (Husky), in joint-venture with Petro-Canada, submitted a Benefits Plan for the White Rose Development to the Canada- Newfoundland and Labrador Offshore Petroleum Board (C-NLOPB). This revised document provided the case for requesting an increase in the facility maximum daily production rate and the average annual production rate for the White Rose field from 100,000 barrels per day (bpd) as stated in the approved White Rose Development Plan to 140,000 bpd. In order to determine the potential for increasing oil production through the Floating Production, Storage and Offloading (FPSO) vessel, two things were considered, namely the proper reservoir management of the White Rose field to ensure optimum resource recovery, and the capacity of the FPSO topsides processing system and supporting utilities to accommodate increased production. This document presented a detailed review of all the ...

2006-09-15

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Index Scriptorium Estoniae

Heliplaadist

2001-01-01

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Assessing the risk of ovarian hyperstimulation syndrome in egg donation: implications for human embryonic stem cell research.

Role of antioxidants in the treatment of male infertility

Stem cell research has important implications for medicine. The source of stem cells influences their therapeutic potential, with stem cells derived from early-stage embryos remaining the most versatile. Somatic cell nuclear transfer (SCNT), a source of embryonic stem cells, allows for understandings about disease development and, more importantly, the ability to yield embryonic stem cell lines that are genetically matched to the somatic cell donor. However, SCNT requires women to donate eggs, which involves injection of ovulation-inducing hormones and egg retrieval through laparoscopy or transvaginal needle aspiration. Risks from this procedure are fiercely debated, most notably risk of ovarian hyperstimulation syndrome (OHSS). This review examines risk of OHSS resulting from oocyte donation. We conclude that risk posed by OHSS in egg donation is not significant enough to warrant undue concern, and much of this can be eliminated when proper ...

2011-09-01

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British Library Electronic Table of Contents (United Kingdom)

Abstract Male infertility continues to be a clinical challenge of increasing significance. While male factors such as decreased semen quality are responsible for 25% of all infertility issues, the etiology of suboptimal semen quality is poorly understood. Many physiological, environmental, and genetic factors have been implicated, including oxidative stress. Oxidative stress is induced by reactive oxygen species (ROS), or free radicals, and although ROS are required for critical aspects of sperm function, excessive levels of ROS can negatively impact sperm quality. The origin of ROS generation, and the etiologies of increased ROS in men with suboptimal sperm quality have only recently been elucidated, offering multiple targets for potential therapy. Here, we present a critical review of th...

2009-01-01

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Cardiac Channelopathies and Sudden Infant Death Syndrome

British Library Electronic Table of Contents (United Kingdom)

Abstract Sudden infant death syndrome (SIDS) is always a devastating and unexpected occurrence. SIDS is the leading cause of death in the first 6 months after birth in the industrialized world. Since the discovery in 1998 of long QT syndrome as an underlying substrate for SIDS, around 10-20% of SIDS cases have been proposed as being caused by genetic variants in either ion channel or ion channel-associated proteins. Until now, 10 cardiac channelopathy susceptibility genes have been found to be implicated in the pathogenesis of SIDS. Four of the genes encode cardiac ion channel a-subunits, 3 genes encode ion channel b-subunits, and 3 genes encode other channel-interacting proteins. All 10 genes have been associated with primary electrical heart diseases. SIDS may hereby be the initial sympt...

2011-01-01

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The role of nitrogen fixation in intensive forestry in Canada. Part 1

The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.

Intensification of forest management and harvesting will lead to increased pressures on relatively infertile forest soils with possible reductions in levels of nitrogen and organic matter. It will be necessary for foresters to manage the soils, along with trees, if they wish to maintain site productivity. Nitrogen fixation should be considered as a supplementary or alternative soil amendment method. Free-living nitrogen-fixing bacteria appear to contribute minor amounts of combined nitrogen to forest soils, but it is possible that this contribution has been underestimated. The nitrogen-fixing symbioses of higher plants with bacteria contribute up to 300 kg year of nitrogen, more than sufficient to replace potential losses of nitrogen in intensive forestry. The nitrogen-fixing process, however, requires sufficient supplies of certain elements and is sensitive to environmental factors. There are numerous examples of nitogen-fixing symbioses improving tree growth and forest soil ...

1984-01-01

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Less waste corn, more land in soybeans, and the switch to genetically modified crops: trends with important implications to wildlife management

In neurodegenerative conditions such as Alzheimer's and prion disease it has been shown that host genetic background can have a significant effect on susceptibility. Indeed, human genome-wide association studies (GWAS) have implicated several candidate genes. Understanding such genetic susceptibility is relevant to risks of developing variant CJD (vCJD) in populations exposed to bovine spongiform encephalopathy (BSE) and understanding mechanisms of neurodegeneration. In mice, aspects of prion disease susceptibility can be modelled by examining the incubation period following experimental inoculation. Quantitative trait linkage studies have already identified multiple candidate genes; however, it is also possible to take an individual candidate gene approach. Rarb and Stmn2 were selected as candidates based on the known association with vCJD. Because of the increasing overlap described between prion and Alzheimer's diseases ...

2010-12-06

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A correction to the governor model moment of inertia

An abundance of waste corn, a key food of many wildlife species, has helped make possible the widespread success of wildlife management in the United States over the past half century. We found waste corn post harvest in Nebraska declined by 47% from 1978 to 1998 due primarily to improvements in combine headers resulting in a marked decline in ear loss. The reduction in waste coincided with major declines in fat storage by sandhill cranes and white-fronted geese during spring migration. Sandhill cranes, northern pintails, white-fronted geese, and lesser snow geese avoided soybeans while staging in spring in the Rainwater Basin Area and Central Platte River Valley. These findings and other literature suggest soybeans are a marginal food for wildlife particularly during periods of high energy requirements. Soybean acreage has increased by 600% in the United States since 1950 and now comprises nearly one-quarter of the nation>'s cropland. With over 80% of the soybean crop now in ...

2004-01-01

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Genetics, Genomics, and Molecular Biology

(15 Aug 1973). Canada Prakash, VR Indian Inst. of Tech., Kanpur. Dept.

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Dosimetric Implications of Atmospheric Dispersal of Tritium Near a Heavy-water Research Reactor Facility

Genetics, Genomics, and Molecular Biology USGS scientists develop and integrate new genetic and molecular techniques into systematic analyses to describe individuals and populations of fish .....

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Molecular Genetics of Emericella nidulans Sexual Development

An estimate of the tritium dose to the public in the vicinity of the heavy water research reactor facility at AECL-Chalk River Laboratories, Ontario, Canada, has largely been accomplished from analyses on regularly-collected samples of air, precipitation, drinking water and foodstuffs (pasture, fruit, vegetables and milk) and environmental dose models. To increase the confidence with which public doses are calculated, tritium doses were estimated directly from the ratio of tritiated species in urine samples from members of the general public. Single cumulative 24 h urine samples from a few adults living in the vicinity of the heavy-water research reactor facility at Chalk River Laboratories, Canada were collected and analysed for tritiated water and organically bound tritium. The participants were from Ottawa (200 km east), Deep River (10 km west) and Chalk River Laboratories. Tritiated water concentrations in urine ranged from 6.5 Bq.l{sup -1} ...

2001-07-01

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Genetic screening: The vista of genomic medicine

Full Text Available

2009-09-01

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SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder

The accelerating development of biochemical and DNA-based diagnostic tests for human genetic conditions in the last decade has engendered a revolution in genetic diagnosis. Both genetic testing and...Full Text Available

2011-01-01

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British Library Electronic Table of Contents (United Kingdom)

Abstract SLC9A9 (solute carrier family 9, member 9, also known as Na+/H+ exchanger member (NHE9)) is a membrane protein that regulates the luminal pH of the recycling endosome, an essential organelle for synaptic transmission and plasticity. SLC9A9 has been implicated in human attention deficit hyperactivity disorder (ADHD) and in rat studies of hyperactivity. We examined the SLC9A9 gene sequence and expression profile in prefrontal cortex, dorsal striatum and hippocampus in two genetic rat models of ADHD. We report two mutations in a rat model of inattentive ADHD, the WKY/NCrl rat, which affect the interaction of SLC9A9 with calcineurin homologous protein (CHP). We observed an age-dependent abnormal expression of SLC9A9 in brains of this inattentive model and in the Spontaneous Hypertensi...

2011-01-01

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Assessing the Significance of Above- and Belowground Carbon Allocation of Fast- and Slow-Growing Families of Loblolly Pine - Final Report

Age at onset in Huntington?s disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7

During this project we experimentally evaluated the below-ground biomass and carbon allocation and partitioning of four different fast- and slow-growing families of loblolly pine located in Scotland County, NC, in an effort to increase the long-term performance of the crop. The trees were subjected to optimal nutrition and control since planting in 1993. Destructive harvests in 1998 and 2000 were used for whole?plant biomass estimates and to identify possible family differences in carbon acquisition (photosynthesis) and water use efficiency. At regular intervals throughout each year we sampled tissues for carbohydrate analyses to assess differences in whole-tree carbon storage. Mini rhizotron observation tubes were installed to monitor root system production and turnover. Stable isotope analysis was used to examine possible functional differences in water and nutrient acquisition of root systems between the various families. A genetic dissection of root ontogenic ...

2001-03-01

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British Library Electronic Table of Contents (United Kingdom)

Huntington?s disease (HD) is caused by an expansion of a polyglutamine repeat of more than 35?units in the huntingtin protein. The expanded repeat length is inversely correlated with the age at onset (AAO); however, additional genetic factors apart from the expanded CAG repeat length can modify the course and the AAO in HD. Aberrations in macroautophagy have been observed in Huntington, Alzheimer, Parkinson, motor neuron and prion diseases. Therefore, we hypothesized that polymorphisms in autophagy-related (Atg) genes might contribute to the variation in the AAO. We initially tested eight single nucleotide polymorphisms in five Atg genes (Atg3, Atg5, Atg7, Atg16L1 and Beclin-1) for their frequency of ?1%. Subsequently, we investigated the polymorphisms Atg7 V471A and Atg16L1 T281A for a di...

2010-01-01

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Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition

Mycotoxins in fungal contaminated samples of animal feed from western Canada, 1982-1994.

B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin B2 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for GC risk were calculated ...

2010-01-01

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Increasing the opportunities for UK-Canada collaboration

Feed samples from 94 cases involving fungal contamination and suspected mycotoxicosis of farm animals in western Canada were examined during 1982-1994 to assess the incidence of mycotoxins. Samples...Full Text Available

1997-01-01

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Imported sparganosis in Canada

This paper outlines the opportunities for UK-Canada collaboration/feasibility studies in areas that include novel research into waste management and decommissioning. A number of Universities in the UK have programs relevant to such collaborations in areas such as fuels; thermal hydraulics, reactor system and materials.

2007-06-03

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Tissue culture and micropropagation for forest biomass production

The first case of human sparganosis in Canada is reported in a 23-year-old woman who emigrated from Greece in 1969. Examination of a ribbon-like worm removed from a painful swelling in the neighbourhood...Full Text Available

1973-03-03

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The carbonate feedback system: interaction between stratigraphic accommodation, ecological succession and the carbonate factory; Le systeme de feed-back des carbonates: une interaction entre accomodation stratigraphique, succession ecologique et l`usine des carbonates

An increase in forest production will be necessary in the future when wood becomes a major renewable source of energy and chemicals along with its traditional role of fibre source. This increase could eventually by achieved be proper selection and breeding of trees. Clonal forestry by vegetative propagation of cuttings is becoming a viable alternative to a seedling-based forestry with many advantages, and cutting could be used to quickly propagate large numbers of clones of control-pollinated seedlings. Most forest trees are propagated sexually and seed orchards were started in the US and Canada in the last 40-50 years for breeding purposes. Forests could ultimately be established with improved seedlings instead of from seed with unknown genetic potential, or by natural regeneration. Micropropagation is the term used to refer to the propagation of plants raised by tissue culture methods rather than from seeds or cuttings. Many clonal plantlets ...

1984-09-01

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Source tracking of Escherichia coli by 16S-23S intergenic spacer region denaturing gradient gel electrophoresis (DGGE) of the rrnB ribosomal operon.

In this paper, the analysis of carbonate depositional systems, using high resolution sequence stratigraphy, studies the ratio between change in accommodation space and skeletal carbonate production. This approach establishes the concurrent change in nature of facies belts (expansion, retraction and type) and fossil communities, within the detailed time frame in accommodation. Carbonate production is generally considered to be a fairly simple function of environmental conditions such as climate and water depth. However, data from several case studies also show a covariance between change in stratigraphic architecture of carbonate systems (the seaward or landward stepping stacking patterns of stratigraphic units) and charge in facies. Case studies include Carboniferous algal mound development in the Paradox Basin (USA), Devonian stromatoporoid reef development in Alberta (Canada), and Cenomanian rudistid shoal development in Oman. The hypotheses are tested on cases ...

1996-12-31

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Entering the Canadian mainstream. [The independent energy market in Canada

This research validates a novel approach for source tracking based on denaturing gradient gel electrophoresis (DGGE) analysis of DNA extracted from Escherichia coli isolates. Escherichia coli from different animal sources and from river samples upstream from, at, and downstream of a combined sewer overflow were subjected to DGGE to determine sequence variations within the 16S-23S intergenic spacer region (ISR) of the rrnB ribosomal operon. The ISR was analyzed to determine if E. coli isolates from various animal sources could be differentiated from each other. DNA isolated from the E. coli animal sources was PCR amplified to isolate the rrnB operon. To prevent amplification of all 7 E. coli ribosomal operons by PCR amplification using universal primers, sequence-specific primers were utilized for the rrnB operon. Another primer set was then used to prepare samples of the 16S-23S ISR for DGGE. Comparison of PCR-DGGE results between human and animal sources revealed differences in the ...

2007-10-01

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Climate change impacts and adaptation : a Canadian perspective

This article examines the developing market for independent power projects in Canada. The topics of the article include bidding in Ontario, the Quebec market, powering British Columbia, and market forces at work in Canada. Discussed are current projects in all stages of completion from bidding to production and includes gas-fired cogeneration, gas-fired combined-cycle electricity generation and cogeneration, wood-waste fired plants, repowering of existing utility plants, and hydroelectric power plants.

1992-04-01

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Chemometric study of functional groups in Pennsylvanian gymnosperm plant organs (Sydney Coalfield, Canada): Implications for chemotaxonomy and assessment of kerogen formation

This book summarizes the research that has been conducted in Canada over the past five years on the issue of climate change impacts on key sectors such as water resources, agriculture, forestry, fisheries, coastal zones, transportation, and human health and well-being. The book refers to the growing evidence that climate change is occurring. The Intergovernmental Panel on Climate Change (IPCC) believes that these changes have already contributed to increases in annual precipitation, cloud cover and extreme temperatures over the last 50 years. It suggests that it in order to develop an effective strategy for adaptation, it is necessary to understand the vulnerability of each sector to climate change in terms of the nature of climate change, the climatic sensitivity of the region being considered, and the capacity to adapt to the changes. Adaptation will require a reduction in greenhouse gas emissions in order to lower the rate of climate change. Problems associated ...

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Genetically-engineered mouse models for pancreatic cancer: Advances and current limitations

The samples comprise the foliage of four pteridosperm-medullosalean plant fossil species of differing preservation states and one of a cordaitean species from two Canadian Maritime sub-basins of Carboniferous age (300 Ma; Sydney and Stellarton coalfields, Nova Scotia, respectively). Included in the sample set were some coal samples from Sydney Coalfield, along with published data for coal macerals for comparison. By applying Schulze's maceration process to the fossil foliage to obtain the cuticles, five sample forms evolved, viz. compressions, cuticles and fossilized cuticles, and acidic and alkaline solutions from Schulze's process, to which was added the Sydney coal samples as the sixth form. Area integration of the absorbance spectra from solid and liquid state Fourier transform infrared (FTIR) spectroscopy, produced functional chemical parameters which were organized into a data matrix of eight variables and 62 samples (8 x 62 matrix). Principal components were ...

2010-12-15

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From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis

Recently, there has been significant progress in the development of genetically-engineered mouse (GEM) models. By introducing genetic alterations and/or signaling alterations of human pancreatic cancer...Full Text Available

2011-05-10

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Evolving hard problems: Generating human genetics datasets with a complex etiology

Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which...Full Text Available

2008-03-01

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Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study

BackgroundA goal of human genetics is to discover genetic factors that influence individuals' susceptibility to common diseases. Most common diseases are thought to result from the...Full Text Available

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THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF EVOLUTIONARY CHANGE MEDIATED BY PHENOTYPIC ...

Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully...Full Text Available

2010-07-01

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Ovine reference materials and assays for prion genetic testing

... 1111/j.1558-5646.2007.00203.x THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF ... to phenotypic plast...

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Molecular Genetics and Carcinogenesis Section

BackgroundGenetic predisposition to scrapie in sheep is associated with several variations in the peptide sequence of the prion protein gene (PRNP). DNA-based tests...Full Text Available

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Mice as a Mammalian Model for Research on the Genetics of Aging

The Molecular Genetics and Carcinogenesis Section conducts studies using human epithelial cells to assess: activation of proto-oncogenes by chemical and physical carcinogens; inactivation and dysregulation of tumor suppressor genes by chemical and physical

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Liver Carcinogenesis Unit

Mice are an ideal mammalian model for studying the genetics of aging: considerable resources are available, the generation time is short, and the environment can be easily controlled, an important...Full Text Available

2011-02-08

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Detection of genetic mutations in repetitive DNA sequences in somatic human cells after low-dose irradiation

The Liver Carcinogenesis Section uses the modern technologies of molecular biology, cell biology, protein chemistry and genetics to investigate the biochemical and genetic pathways involved in human liver cancer.

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Browse Conditions - Genetics Home Reference

... 3-89701-147-6 0949-2224 245 p. animal cells dna genetic radiation effects

1998-03-01

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APPLICATION OF RAPD IN THE DETERMINATION OF GENETIC FIDELITY IN MICROPROPAGATED DROSERA PLANTLETS

Home A service of the U.S. National Library of Medicine® Home Conditions Genes Chromosomes Handbook Glossary Resources Genetic Conditions > Browse Conditions 1-9 | A | B | C...

2011-09-24

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Public health implications of environmental exposures.

... K. Ishii. 1998. Determination of genetic stability in long-term micropropagated shoots of Pinus thunbergii Parl. using RAPD markers. Plant ... ...

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Support required from Canada in the operation and maintenance of CANDU stations overseas

The Agency for Toxic Substances and Disease Registry (ATSDR) is a public health agency with responsibility for assessing the public health implications associated with uncontrolled releases of hazardous...Full Text Available

1998-02-01

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Space Science - NASA Headquarters

The long-term support required from Canada in the operation and maintenance of overseas CANDU nuclear generating stations after commercial operation has commenced is described, with reference entirely to the KANUPP reactor. This includes: technical support to station staff to increase plant reliability and maintainability; assistance with plant improvements; procurement of spares and consumables; and assistance with training programmes. This technical support may be provided by a small number of Canadian staff actually resident at the power station; by short-term visits of Canadian specialists to site and by technical and procurement services provided from Canada. Examples of technical problems experienced are given, showing typical services required from Canada.

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Canada will provide telescope baffles and fine error sensor assemblies. ..... ( Ongoing) Flight tests aboard sounding rockets and balloon planned for FY 1995. .... the effects of incoming energetic particles and solar radiation on the ...

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NOAA Photo Library

Evidence from 12 geographically disparate power grids - NASA

Meat supply hung up for protection against blowflies, bears, dogs, etc. Triangulation work for military on Alcan Highway in Yukon Territory, Canada.

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Annual inside final - NASA

miles of high-voltage transmission lines with 12 intercon- nections to electricity systems in New York and Canada. As of 1 March 2003, ISO New England has ...

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The attendees this year included partic- ipants from space agencies, industry, and academia from Canada, the Czech Republic, France, Germany, Italy, Japan, ...

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Primaquine

Genome structure of cotton revealed by a genome-wide SSR genetic map constructed from a BC₁population between gossypium hirsutum and G. barbadense

... oxygen to the tissues in the body),nicotinamide adenine dinucleotide (NADH) deficiency (a genetic condition), glucose-6- ...

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Genetically and somatically significant radiation doses in the radiotherapy of inflammatory and degenerative diseases

BackgroundCotton, with a large genome, is an important crop throughout the world. A high-density genetic linkage map is the prerequisite for cotton genetics and breeding. A genetic...Full Text Available

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Genetic Stability of Magnaporthe oryzae during Successive Passages through Rice Plants and on Artificial Medium

... pathological changes patients radiation protection radiotherapy diseases

1982-10-25

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Genetic Characterization of Encephalomyocarditis Virus Isolated from Aborted Swine Fetus in Korea

Full Text Available

2010-12-01

70

Multicolor FISH mapping with Alu-PCR-amplified YAC clone DNA determines the order of markers in the BRCA1 region on chromosome 17q12-q21

Full Text Available

2006-10-01

71

Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease

A gene designated BRCA1, implicated in the susceptibility to early-onset familial breast cancer, has recently been localized to chromosome 17q12-q21. To date, the order of DNA markers mapped within this region has been based on genetic linkage analysis. The authors report the use of multicolor fluorescence in situ hybridization to establish a physically based map of five polymorphic DNA markers and 10 cloned genes spanning this region. Three cosmid clones and Alu-PCR-Generated products derived from 12 yeast artificial chromosome clones representing each of these markers were used in two-color mapping experiments to determine an initial proximity of markers relative to each other on metaphase chromosomes. Interphase mapping was then employed to determine the order and orientation of closely spaced loci by direct visualization of fluorescent signals following hybridization of three probes, each detected in a different color. Statistical analysis ...

1993-09-01

72

Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development

Outbreaks of disease attributable to human error or natural causes can provide unique opportunities to gain new information about host-pathogen interactions and new leads for pathogenesis research. Poststreptococcal glomerulonephritis (PSGN), a sequela of infection with pathogenic streptococci, is a common cause of preventable kidney disease worldwide. Although PSGN usually occurs after infection with group A streptococci, organisms of Lancefield group C and G also can be responsible. Despite decades of study, the molecular pathogenesis of PSGN is poorly understood. As a first step toward gaining new information about PSGN pathogenesis, we sequenced the genome of Streptococcus equi subsp. zooepidemicus strain MGCS10565, a group C organism that caused a very large and unusually severe epidemic of nephritis in Brazil. The genome is a circular chromosome of 2,024,171 bp. The genome shares extensive gene content, including many virulence factors, with genetically ...

2008-08-21

73

The canine ehrlichiosis (tropical canine pancytopenia) epizootic in Vietnam and its implications for the veterinary care of military workingn> dogs.

Cdc7 kinase plays an essential role in firing of replication origins by phosphorylating components of the replication complexes. Cdc7 kinase has also been implicated in S phase checkpoint signaling downstream of the ATR and Chk1 kinases. Inactivation of Cdc7 in yeast results in arrest of cell growth with 1C DNA content after completion of the ongoing DNA replication. In contrast, conditional inactivation of Cdc7 in undifferentiated mouse embryonic stem (ES) cells leads to growth arrest with rapid cessation of DNA synthesis, suggesting requirement of Cdc7 functions for continuation of ongoing DNA synthesis. Furthermore, loss of Cdc7 function induces recombinational repair (nuclear Rad51 foci) and G2/M checkpoint responses (inhibition of Cdc2 kinase). Eventually, p53 becomes highly activated and the cells undergo massive p53-dependent apoptosis. Thus, defective origin activation in mammalian cells can generate DNA replication checkpoint signals. Efficient removal of ...

2003-11-27

74

Seawater flue gas desulfurization : its technical implications and performance results

PMID:6429572

1984-06-01

75

Petrology of Spinel lherzolite from South Korea: Implication for P/T Estimate

Udgivelsesdato: APR

2003-01-01

76

Implication of Self-thinning in Salix Communities on Riverine Wetland Restoration

Full Text Available

2002-01-01

77

Health@Home: the work of health information management in the household (HIMH): implications for consumer health informatics (CHI) innovations.

Full Text Available

2007-08-01

78

Electronic measures of surgical site infection: implications for estimating risks and costs.

PMID:16049230

2005-07-27

79

Settlement instrumentation to observe open-pit mine backfill and a prototype foundation in western Canada

PMID:21768762

2011-08-01

80

Exploring Wait List Prioritization and Management Strategies for Publicly Funded Ambulatory Rehabilitation Services in Ontario, Canada: Further Evidence of Barriers to Access for People with Chronic Disease

It is necessary that reclaimed land from open pit mining operations has completely settled before it can be returned to the public domain. This paper reports on instrumentation installed to observe settlement of the spoil and behaviour of a prototype foundation on reclaimed land in Alberta, Canada. 6 refs., 7 figs.

1987-11-01

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81

Canada-Nova Scotia acid rain reduction agreement: Annual report 1989-1990

Background:Timely access to publicly funded health services is a priority issue across the healthcare continuum in Canada. The purpose of this study was to examine wait list management...Full Text Available

2010-05-01

82

Pricing electricity for sustainability : climate change and Canada's electricity sector

This report reviews Nova Scotia's initiatives in support of the Canada-Nova Scotia Acid Rain Reduction Agreement. In addition to discussing sodium dioxide emmisions and potential impacts, the report comments on new developments and initiatives to address other emerging air quality issues.

1990-01-01

83

Pricing electricity for sustainability : climate change and Canada's electricity sector

The electricity sector is Canada's largest single source of greenhouse gas (GHG) emissions. This paper discussed electricity and carbon pricing approaches to reducing GHG emissions in the electricity sector. An overview of the links between electricity pricing and climate change was presented, and current and emerging trends in electricity pricing related to encouraging energy conservation were reviewed. Market prices and failures were discussed. Approaches to pricing electricity included an increase in block prices; time-of-use prices; demand-side management and energy efficiency; and carbon pricing in Canada and electricity pricing signals. The study showed that several provincial utilities in Canada are experimenting with market-based pricing approaches for electricity and carbon that may help to reduce GHG emissions over time. Concerns over electricity supply and the negative environmental impacts of electricity ...

84

Genetic diversity among Angus, American Brahman, Senepol and Romosinuano cattle breeds:

The electricity sector is Canada's largest single source of greenhouse gas (GHG) emissions. This paper discussed electricity and carbon pricing approaches to reducing GHG emissions in the electricity sector. An overview of the links between electricity pricing and climate change was presented, and current and emerging trends in electricity pricing related to encouraging energy conservation were reviewed. Market prices and failures were discussed. Approaches to pricing electricity included an increase in block prices; time-of-use prices; demand-side management and energy efficiency; and carbon pricing in Canada and electricity pricing signals. The study showed that several provincial utilities in Canada are experimenting with market-based pricing approaches for electricity and carbon that may help to reduce GHG emissions over time. Concerns over electricity supply and the negative environmental impacts of ...

2010-01-15

85

British Library Electronic Table of Contents (United Kingdom)

Summary The objective of this study was to quantify the genetic diversity among breeds under evaluation for tropical adaptability traits that affect the performance of beef cattle at the USDA/ARS SubTropical Agricultural Research Station (STARS) near Brooksville, FL, USA. Twenty-six microsatellite loci were used to estimate parameters of genetic diversity among the breeds American Brahman, Angus, Senepol and Romosinuano; the latter was comprised of two distinct bloodlines (Costa Rican and Venezuelan). Genotypes of 47 animals from each of these STARS herds were analysed for genetic diversity and genetic distance. Using two methods, the greatest genetic distance was detected between the Costa Rican line of Romosinuano and the Senepol. Gene diversity ranged between 0.64 (Costa Rican line of R...

2007-01-01

86

Zebrafish: A Model System for the Study of Eye Genetics

Use of Forward Genetics to Discover Novel Regulators of NF-?B

Over the last decade, the use of the zebrafish as a genetic model has moved beyond the proof-of-concept for the analysis of vertebrate embryonic development to demonstrated utility as a mainstream...Full Text Available

2008-01-01

87

Tissue Effect on Genetic Control of Transcript Isoform Variation

Forward and reverse genetic experiments have both played important roles in revealing critical aspects of mammalian signal transduction pathways in cell culture experiments. Only recently have we begun...Full Text Available

2010-06-01

88

Survival of Genetically Modified and Self-Cloned Strains of Commercial Baker's Yeast in Simulated Natural Environments: Environmental Risk Assessment

Current genome-wide association studies (GWAS) are moving towards the use of large cohorts of primary cell lines to study a disease of interest and to assign biological relevance to the genetic signals...Full Text Available

2009-08-01

89

Strategies for the production of genetically identical monkeys by embryo splitting

Although genetic engineering techniques for baker's yeast might improve the yeast's fermentation characteristics, the lack of scientific data on the survival of such strains in natural environments...Full Text Available

2005-11-01

90

Reproduction in three genetic lines of dairy cattle housed a total confinement system.

Genetically identical rhesus monkeys would have tremendous utility as models for the study of human disease and would be particularly valuable for vaccine trials and tissue transplantation studies where...Full Text Available

91

Radiation risks for medical applications

Dairy cattle of three genetic lines maintained year round in total confinement (either in loose housing or tie stall barn) were monitored for estrous cycle activity and reproductive performance. Only...Full Text Available

1981-10-01

92

RISK-XLR: A Microcomputer-Based Genetic Risk Program for X-Linked Recessive Traits

The achievements made in the field of radiation protection over the past 20 years are outlined. Risk analysis as applied to medicine is considered and genetic significant doses, genetic risks, somatic effective doses and somatic risks are discussed. (C.F.).

1980-05-31

93

Potential of plant genetic systems for monitoring and screening mutagens

A computer program, RISK-XLR, which calculates genetic risk for carrier status of a Mendelian X-linked recessive condition has been written for the Macintosh series of microcomputers. The program,...Full Text Available

1987-11-04

94

Persistence of genetic variants of the arctic fox strain of Rabies virus in southern Ontario

Plants have too long been ignored as useful screening and monitoring systems of environmental mutagens. However, there are about a dozen reliable, some even unique, plant genetic systems that can increase...Full Text Available

1978-12-01

95

Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis

AbstractGenetic-variant analysis of rabies viruses provides the most sensitive epidemiologic tool for following the spread and persistence of these viruses in their wildlife hosts. Since...Full Text Available

2006-01-01

96

Heritability of Measures of Kidney Disease Among Zuni Indians: The Zuni Kidney Project

Auxin modulates diverse plant developmental pathways through direct transcriptional regulation and cooperative signaling with other plant hormones. Genetic and biochemical approaches have clarified...Full Text Available

2004-10-12

97

Genetic susceptibility to systemic lupus erythematosus in the genomic era

BackgroundThe long-term goal of the GKDZI (Genetics of Kidney Disease in Zuni Indians) Study is to identify genes, environmental factors, and genetic-environmental...Full Text Available

2010-08-01

98

Genetic relationship between anxiety- and fear -related behaviors in BXD recombinant inbred mice

Our understanding of the genetic basis of systemic lupus erythematosus (SLE) has been rapidly advanced using large-scale, case–control, candidate gene studies as well as genome-wide...Full Text Available

2010-12-01

99

Genetic predisposition for femoral neck stress fractures in military conscripts

Mood and anxiety disorders and rodent phenotypic measures modeling these disorders have a strong genetic component. Various assays are used to study the neurobiological basis of fear- and anxiety-related...Full Text Available

2009-03-01

100

Genetic evidence of illegal trade in protected whales links Japan with the US and South Korea

BackgroundStress fractures are a significant problem among athletes and soldiers and may result in devastating complications or even permanent handicap. Genetic factors may increase...Full Text Available

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101

Genetic aspects of birth defects: new understandings of old problems

We report on genetic identification of ‘whale meat’ purchased in sushi restaurants in Los Angeles, CA (USA) in October 2009 and in Seoul, South Korea in June and September 2009. Phylogenetic...Full Text Available

2010-10-23

102

Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

Over the past two decades, combined advances in genetics, developmental biology and biochemistry have transformed the study of human birth defects. This review describes the importance of genome architecture,...Full Text Available

2007-07-01

103

Genetic Monitoring and Evaluation Program for Supplemented Populations of Salmon and Steelhead in the Snake River Basin, 1990-1991 Annual Report.

The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the magnitude...Full Text Available

2008-12-16

104

Genetic Elucidation of Human Hyperosmia to Isovaleric Acid

This is the first report of research for an ongoing study to evaluate the genetic effects of using hatchery-reared fish to supplement natural populations of chinook salmon and steelhead in the Snake River Basin.

1991-08-01

105

Genetic Diversity Assessment of Rarely Cultivated Traditional Indica Rice (Oryza sativa L.) Varieties

The genetic basis of odorant-specific variations in human olfactory thresholds, and in particular of enhanced odorant sensitivity (hyperosmia), remains largely unknown. Olfactory receptor (OR) segregating...Full Text Available

2007-11-01

106

Energy metabolism of the untrained muscle of elite runners as observed by 31P magnetic resonance spectroscopy: evidence suggesting a genetic endowment for endurance exercise.

Random amplified polymorphic DNA fingerprinting was performed to assess the genetic diversity among rarely cultivated traditional indica rice (Oryza sativa ...Full Text Available

107

Effect of Feeding Cows Genetically Modified Maize on the Bacterial Community in the Bovine Rumen?

The purpose of this study was to investigate whether genetically determined properties of muscle metabolism contribute to the exceptional physical endurance of world-class distance runners. ATP, phosphocreatine,...Full Text Available

1988-12-01

108

Creating genetically modified pigs by using nuclear transfer

Rumen-cannulated cows (n = 4) were fed successively silage made from either conventional or genetically modified (GM) maize. Results revealed no effects of GM maize on the dynamics...Full Text Available

2007-12-01

109

Construction and Application of a Zebrafish Array CGH Platform

Nuclear transfer (NT) is a procedure by which genetically identical individuals can be created. The technology of pig somatic NT, including in vitro maturation of oocytes, isolation and treatment of...Full Text Available

110

Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease

The zebrafish is emerging as a prominent model system for studying the genetics of human development and disease. Genetic alterations that underlie each mutant model can exist in the form of...Full Text Available

2009-02-01

111

A Strong Case for Viral Genetic Factors in HIV Virulence

This study examined the genetic basis of hypertension and renal disease in Dahl SS/Mcwi (Dahl Salt-Sensitive) rats using a complete chromosome substitution panel of consomic rats in which each of the...Full Text Available

2008-09-01

112

A Cytogenetic Abnormality and Rare Coding Variants Identify ABCA13 as a Candidate Gene in Schizophrenia, Bipolar Disorder, and Depression

HIV infections show great variation in the rate of progression to disease, and the role of viral genetic factors in this variation had remained poorly characterized until recently. Now a series of four...Full Text Available

113

Soil microbial toxicity of eight polycyclic aromatic compounds: effects on nitrification, the genetic diversity of bacteria, and the total number of protozoans.

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of ∼80% indicating a substantial genetic component. Population genetics...Full Text Available

2009-12-11

114

Primer for the Potato Specific Internal Control DNA and Screening Method for the Genetically Modified Potatoes by Competitive Duplex-PCR

Udgivelsesdato: 2002-Aug

2002-01-01

115

Genetic Applications in Avian Conservation

Full Text Available

2002-12-01

116

Radiogenic age and isotopic studies

... structure along an elevational gradient in Hawaiian honeycreepers reveals contrasting evolutionary responses to avian malaria. BMC Evolutionary Biology 8: ... ...

117

Power from triticale straw

This is one of an annual collection of reports presenting data from the Geochronology Section of the Continental Geoscience Division of the Geological Survey of Canada (GSC). The main purpose of this collection is to make geochronological and other radiogenic isotope data produced by the section available promptly to the geological community. Reports make full presentation of the data, relate these to field settings and make comparatively short interpretations. Other geochronological and isotope data produced in the laboratory but published in outside journals or separate GSC publications are summarized at the end of this report. Report 5 contains 24 papers from most regions of Canada, but particularly from British Columbia. The Geochronology Laboratory has, over the years, provided substantial U-Pb dating for the Cordilleran Division of the Geological Survey of Canada in Vancouver, and the results of a number of these ...

1999-02-01

118

Ground temperature histories in eastern and central Canada from geothermal measurements - evidence of climatic change

This study examined the feasibility of using triticale straw for production of electricity in Canada. Triticale is a manmade hybrid of wheat and rye and it has a high potential of growth in Canada. The cost ($/MWh) of producing electricity from triticale straw was estimated using a data intensive techno-economic model. The study also determined the optimum size of a biomass power plant (MW) which is a trade-off between capital cost of the plant and transportation cost of biomass. Cost curves were also developed in order to evaluate the impact of scale on power production costs. The location of the power plant and the future expansion of triticale were among the factors considered in the techno-economic mode. The scope of the work included all the processes beginning with the collection of straw to the conversion to electricity through direct combustion at the power plant. According to the preliminary results, the cost of producing power from ...

2010-07-01

119

Case studies and educational aids survey. A research report

Inverse and direct methods have been used to analyze a large number of borehole temperature logs in order to infer past climatic changes. Results indicate a warming of 1-2[degree]C in eastern and central Canada during the past 150 years. A period of cooling between 500 and 200 years before present, corresponding to the time of the Little Ice Age, has also been identified in the same areas. A regional ground temperature history is estimated for eastern and central Canada from the simultaneous inversion of several temperature logs. The inferred temperature changes appear correlated with the concentration of atmospheric carbon dioxide as reported from a Greenland ice core, and agree with existing meteorological and dendrochronological records for the area.

1992-12-01

120

Appendix B : Environment report : Securing a sustainable future for Canada`s oil sands industry

A survey was conducted to determine the sources of buildings energy conservation case studies and educational aids available in Canada. In total 785 consultants, educational institutions, building developers, manufacturers and government agencies were contacted. The results of this survey provide an indication of those agencies in Canada most actively involved with energy conservation in buildings, a listing of those agencies in Canada having case study information and/or educational aids materials available related to energy conservation in buildings, and a broad description of the subject area of the case studies and educational aids listed. The results of this study are intended to provide a source listing of energy conservation case studies and educational aids to the Buildings Energy Technology Transfer Program lead agencies and others conducting similar studies in the buildings sectors for use as resource materials. ...

1983-09-01

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121

Genetic and somatic risks in X-ray diagnosis

The oil sands industry in Canada was said to be committed to environmentally sustainable economic development, i.e. a development that recognizes the mutual dependence of a healthy environment and a healthy economy. To indicate progress toward this goal, the report pointed out the investment of millions of dollars in environmental research and tens of millions of dollars in plant equipment already made. These infrastructure investments have paid dividends in terms of energy conservation, reduction of greenhouse gas emissions, land reclamation, air quality monitoring, water conservation, and water quality and biodiversity protection. A number of recommendations governing provincial jurisdictions over regulations were made. Particular concern was expressed over fairness, and overlapping of regulations by different levels of government.

1995-12-01

122

Local chromatin structure of heterochromatin regulates repeatedDNA stability, nucleolus structure, and genome integrity

Based on a literature study an actual summary of the risk-utility problems in X-ray diagnosis is outlined due to the Recommendations of the International Commission for Radiation Protection (ICRP publication 26/1977). Papers demonstrating quantitative assessment of the somatic and genetical risk in X-ray examination are preferably cited and evaluated. It is concluded that the somatic and genetical risk is low in diagnostic ratiology. However, it must not be neglected and has always to be compared to the utility of an examination as well as to other risks of the examination. (author).

1982-01-01

123

Oral Health in Women During Preconception and Pregnancy: Implications for Birth Outcomes and Infant Oral Health

Heterochromatin constitutes a significant portion of the genome in higher eukaryotes; approximately 30% in Drosophila and human. Heterochromatin contains a high repeat DNA content and a low density of protein-encoding genes. In contrast, euchromatin is composed mostly of unique sequences and contains the majority of single-copy genes. Genetic and cytological studies demonstrated that heterochromatin exhibits regulatory roles in chromosome organization, centromere function and telomere protection. As an epigenetically regulated structure, heterochromatin formation is not defined by any DNA sequence consensus. Heterochromatin is characterized by its association with nucleosomes containing methylated-lysine 9 of histone H3 (H3K9me), heterochromatin protein 1 (HP1) that binds H3K9me, and Su(var)3-9, which methylates H3K9 and binds HP1. Heterochromatin formation and functions are influenced by HP1, Su(var)3-9, and the RNA interference (RNAi) pathway. My thesis project ...

2007-05-05

124

Isolation and characterization of a new Cytophaga species implicated in a work-related lung disease.

The mouth is an obvious portal of entry to the body, and oral health reflects and influences general health and well being. Maternal oral health has significant implications for birth outcomes and infant...Full Text Available

2006-09-01

125

Energy and economy - global interdependencies. Proceedings. Vol. 9. Implications of environmental issues

A yellow-pigmented, gram-negative, gliding bacterium isolated from an industrial water spray air humidification system was implicated as a causative agent in several occurrences of lung disease with...Full Text Available

1984-11-01

126

Correctional health care: implications for public health policy.

The 7 conference papers in Vol. 9 review the implications of environmental problems and discuss the consequences of pollution abatement measures, especially for the economics of energy conversion. The future developments of pollutant emissions are assessed.

1985-01-01

127

Germinating a New SEAD: The Implications of Executing the ...

"Correctional Health Care: Implications for Public Health Policy" is the first in a series of articles that examines the special health care needs of persons who are incarcerated in America's correctional...Full Text Available

2002-05-01

128

Translational bioinformatics and healthcare informatics: computational and ethical challenges.

... Possessing the unique perspective of space, space-based weapons can immediately ... A weapon system with enough space-based platforms at ...

2001-06-01

129

White Rose Development Plan amendment South White Rose extension tie back

Exponentially growing biological and bioinformatics data sets present a challenge and an opportunity for researchers to contribute to the understanding of the genetic basis of phenotypes. Due to breakthroughs in microarray technology, it is possible to simultaneously monitor the expressions of thousands of genes, and it is imperative that researchers have access to the clinical data to understand the genetics and proteomics of the diseased tissue. This technology could be a landmark in personalized medicine, which will provide storage for clinical and genetic data in electronic health records (EHRs). In this paper, we explore the computational and ethical challenges that emanate from the intersection of bioinformatics and healthcare informatics research. We describe the current situation of the EHR and its capabilities to store clinical and genetic data and then discuss the Genetic ...

2009-09-16

130

Triassic petroleum geology, Western Canada Basin and neighbouring Yukon Territory and American regions: Bibliography and summary

In January 2001, Husky Oil Operations Limited (Husky), in joint-venture with Petro-Canada submitted a Development Application (DA) to the Canada-Newfoundland and Labrador Offshore Petroleum Board (C-NLOPB) for the White Rose Development. This DA was prepared following the Canada-Newfoundland Atlantic Accord Implementation Act and the Canada-Newfoundland and Labrador Atlantic Accord Implementation Newfoundland and Labrador Act. In December 2001, the C-NLOPB approved the White Rose DA. This document outlined a proposed amendment to the original Development Plan involving an expansion of its White Rose Development in the Jeanne d'Arc Basin on the Grand Bank. The expansion will consist of a subsea tie-back to the Floating Production, Storage and Offloading (FPSO) vessel through the existing Southern Glory Hole (SGH) and utilizing a new glory hole constructed approximately 4 km south of the SGH. The ...

2006-09-15

131

Tick-Borne Relapsing Fever in British Columbia, Canada: First Isolation of Borrelia hermsii

In the Western Canada Basin, Triassic sedimentary rocks were deposited as a northeasterly-tapering wedge of sediment on the Triassic cratonic Interior Platform and adjacent miogeoclinal areas and occurring within the present day Interior Plains and Rocky Mountain Foothills and Front Ranges of Manitoba, Saskatchewan, Alberta and northeastern British Columbia. Continued drilling activity and recent significant discoveries such as the Spirit River, Brassey, Ring-Pedigree ('Border'), Sukunka, Bullmoose West fields, and new unnamed fields in the Brazion-Monkman area, confirm the petroleum potential of Triassic rocks in this basin. A bibliography of 382 publications and a short test that summarizes the regional setting, stratigraphy and petroleum geology of these Triassic rocks, are provided. This paper is designed to help explorationists or geological researchers become more familiar with Western Canada Basin Triassic rocks and ...

1993-12-01

132

The relationship among current management systems, production, disease and drug usage on Ontario dairy farms.

The spirochete that causes tick-borne relapsing fever, Borrelia hermsii, was isolated in pure culture during 1995 and 1996 from three acutely ill human patients infected in southern...Full Text Available

1998-12-01

133

The Canadian Beef Industry

The study involved 110 randomly selected dairy farms located in the Ontario, Canada counties of Bruce, Grey, Huron, Oxford, Perth, Waterloo and Wellington. Herds were classified as "intensive" and "extensive"....Full Text Available

1986-01-01

134

Santonian To ?Earliest Campanian (Late Cretaceous) Fungi from the Milk River Formation, Southern Alberta, Canada

The cattle industry in Canada has changed greatly over the past several decades. Size of the national dairy herd has reduced steadily but this reduction has been more than offset by an increase in...Full Text Available

1980-02-01

135

Remote environmental monitoring at No. 26 Colliery

... its infancy. However, the geological record of many fossil fungi is well established (Elsik, 1996; Kalgutkar and Jansonius, ... 1988). A comprehensive account of the history of fossil fungi, and the impor...

136

Ontario Timber Inventory (OTI) Level-I Digital Data - NASA

The author describes the layout of the environmental monitoring scheme at Devco's No. 26 Colliery in Canada, which includes wall face ventilation, fan performance, and methane drainage monitoring. He gives details of the sensors, outstations, and the surface control room.

1982-03-01

137

Name techniques in Canada: current trends in utilization rates and recommendations for their inclusion at the Canadian Memorial Chiropractic College

Abstract: Data currently available in the Ontario Timber Inventory include Canada ... Download 1:250 000 scale Ontario Timber Inventory data in Arc Export ...

138

Malignant melanoma of the skin among workers in a telecommunications industry: mortality study 1976-83.

Since its establishment in 1945, the Canadian Memorial Chiropractic College (CMCC) has predominately adhered to a Diversified model of chiropractic technique in the core curriculum; however, many students...Full Text Available

2000-09-01

139

In vivo imaging of neutrotransmitter functions in brain, heart and tumors

An incidence study of malignant melanoma of the skin (MMS), conducted previously among the workers of four plants of a large telecommunications industry located in Montreal, Canada, showed a standardised...Full Text Available

1992-10-01

140

In Vitro Antimicrobial Susceptibilities of Streptococcus pneumoniae Clinical Isolates Obtained in Canada in 2002

This volume contains the proceedings of a symposium entitled In Vivo Imaging of Neurotransmitter Function in Brain, Heart, and Tumors'' held August 24--25, 1990 in Montreal Canada. The six individual papers contained herein are separately abstracted and indexed for the database.

1991-01-01

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141

Impact of Bt corn pollen on monarch butterfly populations: A risk assessment

Empirical treatment is best guided by current surveillance of local resistance patterns. The goal of this study is to characterize the prevalence of antimicrobial nonsusceptibility within pneumococcal...Full Text Available

2004-09-01

142

Effects of Manufacturing Defects and Scaling on Glass Fiber Composite Sandwich Panels in General Aviation Aircraft Structures.

A collaborative research effort by scientists in several states and in Canada has produced information to develop a formal risk assessment of the impact of Bt corn on monarch butterfly...Full Text Available

2001-10-09

143

Diagnosis and management of hepatocellular carcinoma: results of a consensus meeting of The Ottawa Hospital Cancer Centre

This report documents the collaborative effort between the United States and Canada to investigate the impact of process-induced defects on strength and stiffness under static and fatigue loading and for low-cost composite aircraft structures, in particul...

2009-01-01

144

Dendrochronological Mass Balance Reconstruction, Strathcona Provincial Park, Vancouver Island, British Columbia, Canada

Hepatocellular carcinoma (hcc) is an uncommon tumour, but its incidence is increasing in Canada and elsewhere. Currently, there are no Canadian recommendations for diagnosis and treatment of...Full Text Available

2010-04-01

145

Demographics, aging and health care: is there a crisis?

... 036[0598:DMBRSP]2.0.CO;2 Dendrochronological Mass Balance Reconstruction, Strathcona Provincial Park, Vancouver Island, British ...

146

Colorectal Cancer Association of Canada consensus meeting: raising the standards of care for early-stage rectal cancer

Will the aging of Canada's population bankrupt the health care system? In this issue (see pages 1555 to 1560) Dr. Marie Demers reports that the increase in physician service costs for elderly people...Full Text Available

1996-12-01

147

Canada in the world power market

The purpose of the meeting reported here was to develop a set of national evidence-based standards for assessing and managing patients with potentially resectable rectal cancer. This report represents...Full Text Available

2009-12-01

148

Atomic Energy of Canada Limited-Chemical Company Annual Review of Operations, 1980-81.

Canadian power and industrial projects world-wide are highlighted in this annual feature. A short section on the CANDU Wolsung Reactor in the Republic of Korea mentions that it went critical in November 1982 after taking only 60 months to complete.

1983-01-01

149

Assessment and management of patients with chronic cough by Certified Respiratory Educators: A randomized controlled trial

Record production of heavy water was achieved: the plants at Glace Bay and Port Hawkesbury, Nova Scotia, produced a total of 560 megagrams. A shipment of 500 Mg was delivered on time to the Wolsung CANDU reactor in Korea. Energy conservation and waste hea...

1981-01-01

150

NPD Canada's first nuclear power station

BACKGROUND:The value of other health care professionals is increasingly being recognized to compensate for the shortage of physicians in Canada. Chronic cough is one of the most...Full Text Available

2009-02-01

151

Core simulations using actual detector readings for a Canada deuterium uranium reactor

This talk reviews the history of the Canadian nuclear-electric program highlighting Canada's first nuclear power station, the Nuclear Power Demonstration or NPD. NPD was commissioned and delivered electricity to Canadian consumers for the first time on june 4, 1962. The Canadian nuclear-electric program is based on the CANDU-PHW (Canadian Deuterium Uranium - Pressurized Heavy Water) concept which was conceived between 1955 and 1958 at the Chalk River Nuclear Laboratory (CRNL) of AECL, located a few miles from Deep River. This talk covers the history of the Canadian nuclear-electric activities dating back to 1939.

2002-07-01

152

Reasons for decision in the matter of TransCanada PipeLines Limited. Motifs de decision (relative a) TransCanada Pipelines Limited; Volume 3. Installations, exportations de gaz et demandes deposees en vertu de l'article 71

This paper reports that, to obtain better simulation results for a Canada deuterium uranium (CANDU) reactor operation, a new simulation method is developed that uses actual detector readings as a correction factor. Detector readings from a CANDU reactor are used to correct the calculated flux distribution during core calculation iterations. A suitable function is found to describe the relationship between the detector flux and the fluxes of mesh points around the detector. The new simulation method is tested by performing numerical calculations for the Wolsung reactor (a CANDU-600). The results show that the new method predicts the core state more accurately with fewer iterations.

1991-02-01

153

Development of a system model for the postclosure assessment of a concept for geological disposal of Canada`s nuclear fuel waste

TransCanada Pipelines Limited submitted an application to the National Energy Board for new facilities to increase natural gas deliveries to its domestic and export markets. The proposed facilities consist of 1,590 km of pipeline, 21 new compressor units and two new compressor stations. The total cost of the facilities was estimated at $2,408 million. The Board considered at the hearing 15 applications made pursuant to Part IV of the National Energy Board Act for gas exports at existing delivery points at Emerson and Niagra Falls as well as at proposed new delivery points at Chippawa and Iroquois, Ontario. Twelve of these applications were filed in support of TransCanada's facilities application. Five applications were also filed pursuant to section 71 of the National Energy Board Act for orders requiring TransCanada to receive, transport and deliver natural gas offered by the applicants and to provide adequate and ...

1991-04-01

154

Canada vs. the OECD: an environmental comparison

Atomic Energy of Canada has recently submitted for regulatory and public review an Environmental Impact Statement (EIS) on a concept for disposal of Canada`s nuclear fuel waste. The EIS is supported by nine primary references that summarize major aspects of the concept, including a postclosure environmental and safety assessment. The scope of the postclosure assessment is largely determined by the requirements of the Atomic Energy Control Board (AECB) of Canada. These requirements include a quantitative estimate of the annual effective dose equivalent to an individual in the most exposed group of people (the critical group) for 10,000 years following closure of the disposal facility, and a radiological risk criterion with an associated dose rate limit of 0.05 mSv/a. Over this long time frame, a quantitative assessment cannot be based on actual observations, and thus we use scientific arguments and simulations with ...

1995-12-01

155

Forest genetics: research and application in Indian forestry

Canada's environmental performance is compared to the 28 other nations in the Organization for Economic Cooperation and Development (OECD). Twenty-five environmental indicators in ten categories are examined. These are: air, water, energy, biodiversity, waste, climate change, ozone depletion, agriculture, transportation and miscellaneous. Results show Canada with the poorest environmental record of all OECD countries, except the United States. The statistical information, compiled from data verified and published by the OECD, shows Canada among the worst three countries on nine indicators (per capita GHG emissions, CO and VOCs emissions, water consumption, energy consumption, energy efficiency, volume of timber logged, generation of nuclear waste, and the highest amount of energy consumed per unit of GDP). Tracking Canada's energy performance over the past two decades reveals that the situation is ...

156

Genetic variability, heritability and genetic advance for seedling traits in sorghum genotypes

Sufficient genetic diversity exists in Indian tree species to give large genetic gains. Improvement potential, using wild gene resources for selection and breeding is vast as there are over 244 genera and 400 forest tree species in India. Of these over 30 species and 22 genera are of outstanding forestry value. Selective genetic-variation can be lifted from wild populations, multiplied vegetatively or by seed, and planted with controlled germplasm sources. Among the Indian species no less than 74 reproduce by cutting, 11 by layers, 9 by grafting and buding and 104 by root suckers. More than 161 species coppice vigorously. Afforestation techniques of over 170 species have been worked out. Tree genetic approach of survey of natural variability, quick evaluation, selection, conservation multiplication and planting superior variability directly in the field can give immediate genetic ...

1981-04-01

157

Exons, Introns and Talking Genes: The Sience Behind the Human Genome Project

Analysis of data on seedling traits from 20 diverse genotypes revealed significant differences fro most of the seedling traits. Significant estimates of broad-sense heritability were observed for VI, ERI, FRTW, DRTW and R/S ratio. Genetic advance was maximum for VI,ERI and E%. The correlation of VI with ERI and R/S ratio was negative and significant, whereas it was positive and significant with E%, FSHW and DSHW. Characterization of the sorghum genotypes according to Anderson's Metro glyph Statistics revealed five different groups for seedling trails. (authors)

1999-01-01

158

Widespread duplications in the genomes of laboratory stocks of Dictyostelium discoideum

This book presents in simple terms the basis of molecular genetics and how it is used to obtain an understanding of the human genome. The author's central focus is the transistion of genetics from statistics to experimental manipulations, and he offers analogies that help readers visualize the genome, thereby avoiding conventional scientific presentations. He illustrates how genetics is used in scientific laboratories, in courtrooms, and in hospitals. Little is presented about the complex social and ethical issues raised by the Human Genome project.

1993-01-01

159

Two-phase application of multi-objective genetic algorithms in green building design

BackgroundDuplications of stretches of the genome are an important source of individual genetic variation, but their unrecognized presence in laboratory organisms would be a confounding...Full Text Available

2008-01-01

160

The evaluation of risks from radiation

The application of multi-objective genetic algorithms for green building design in two phases were presented in order to better help designers in the decision-making process. The purpose is to minimize two conflicting criteria: the life-cycle cost and the life-cycle environmental impact. Environmental impact criteria examined include energy and non-energy natural resources, global warming, and acidification. Variables focus on building envelope-related parameters. The application of multi-objective genetic algorithms is divided into two phases. The first phase intends to help designers in understanding the trade-off relationship between the two conflicting criteria. The second phase intends to refine the performance region that is of the designer's interest. The results after the two-phase application of the multi objective genetic algorithm were then presented. 13 refs., 4 tabs., 3 figs.

2005-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

The burden of genetically determined eye disease.

German translation of the publication 'The evaluation of risks from radiation' published in 1965 by the International Commission on Radiological Protection. In a survey, genetic and somatic risks from radiation are presented and explained. (HP).

1977-01-01

162

The biological aspects and behaviour of Heliothis virescens Fabricius adults from irradiated diapausal pupae

We determined the underlying aetiology of blindness for the registered blind population of the Province of Newfoundland and Labrador. In both 1981 and 1984 single-gene disorders accounted for 30% of...Full Text Available

1986-09-01

163

Telomeres and telomerase in cancer

... bollworm fertility gamma radiation genetic radiation effects life span mating

1974-07-22

164

Spatial Epidemiology: Current Approaches and Future Challenges

Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic events commandeer many signaling pathways that cooperate to endow aspiring...Full Text Available

2010-01-01

165

Salicylate Metabolism in Twins

Spatial epidemiology is the description and analysis of geographic variations in disease with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk factors....Full Text Available

2004-06-01

166

Role of the 5HT3 Receptor in Alcohol Drinking and ...

To evaluate the contribution of genetic influences on the individual variation in plateau serum salicylate levels, salicylate metabolism was studied in seven pairs of identical and six pairs of fraternal...Full Text Available

1977-07-01

167

Retinoids for Treatment of Retinal Diseases

... Proc Natl Acad Sci USA 97:11032-7 27. Duman RS 2002 Genetics of childhood disorders: XXXIX. Stem cell research, part 3: ...

2005-09-01

168

Principles of antibody therapy.

Knowledge about retinal photoreceptor signal transduction and the visual cycle required for normal eyesight has expanded exponentially over the past decade. Substantial progress in human genetics...Full Text Available

2010-06-01

169

Pharmacogenetics of aspirin resistance: a comprehensive systematic review

The success of monoclonal antibodies in clinical practice is dependent on good design. Finding a suitable target is the most important part as other properties of the antibody can be altered by genetic...Full Text Available

1992-12-05

170

Myxoviruses Monitoring in Seals Populations

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECTA genetic basis for aspirin resistance has been postulated to exist.The...Full Text Available

2008-08-01

171

POSTNOTE

Wastenet

the environment, with the 2006 release of a GM pink bollworm moth (a pest of cotton), ...Use of Genetically Engineered Fruit Fly and Pink Bollworm in APHIS Plant Pest Control Programs 6 Gould,

172

International Science & Technology Center (ISTC)

Comparative Molecular Genetic Monitoring of Myxoviruses Circulating in Populations of Seals Phoca Caspia and Phoca Sibirica in Northern Caspian Region and Lake Baikal

173

Mutations in RNA Binding Protein Gene Cause Familial Dilated Cardiomyopathy

Molecular based assessment of genetic diversity within Barbary fig (Opuntia ficus indica (L.) Mill.) in Tunisia

ObjectivesWe sought to identify a novel gene for dilated cardiomyopathy (DCM).BackgroundDCM is a heritable, genetically...Full Text Available

2009-09-01

174

British Library Electronic Table of Contents (United Kingdom)

In this work, we report for the first time on the analysis of genetic diversity within a set of 36 Tunisian Opuntia ficus indica (L.) Mill. ecotypes using RAPD markers.Random decamer primers were screened to assess their ability to detect polymorphisms in this plant crop. Thirty-nine RAPD markers were revealed and used to survey the genetic diversity at the DNA level and to establish relationships.Consequently, considerable genetic diversity was detected and the UPGMA analysis permitted the discrimination of all the genotypes and enabled their sorting into thirteen groups. The accession `R Sbiba inerme' was significantly divergent from all tested genotypes. In addition, as shown by the clustering the tested genotypes did not significantly diverge, though originating from different localiti...

2007-01-01

175

Microarray-based gene expression profiles of silkworm brains

Loss of genetic connectivity and diversity in urban microreserves in a southern California endemic Jerusalem cricket (Orthoptera: Stenopelmatidae: Stenopelmatus n. sp. ?santa monica??)

BackgroundMolecular genetic studies of Bombyx mori have led to profound advances in our understanding of the regulation of development. Bombyx mori brain,...Full Text Available

176

British Library Electronic Table of Contents (United Kingdom)

Microreserves may be useful in protecting native arthropod diversity in urbanized landscapes. However, species that do not disperse through the urban matrix may eventually be lost from these fragments. Population extinctions may be precipitated by an increase in genetic differentiation among fragments and loss of genetic diversity within fragments, and these effects should become stronger with time. We analyzed population genetic structure in the dispersal limited Jerusalem cricket Stenopelmatus n. sp. ?santa monica?? in the Santa Monica Mountains and Simi Hills north of Los Angeles, California (CA), to determine the impacts of fragmentation over the past 70 years. MtDNA divergence was greater among urban fragments than within contiguous habitat and was positively correlated with fragment ...

2009-01-01

177

Imaging immune response in vivo

Genomics of human longevity

PurposeClinical trials have commenced to evaluate the feasibility of targeting malignant gliomas with genetically engineered cytolytic T-cells (CTLs) delivered directly...Full Text Available

2008-06-15

178

Genetic structure of gilthead seabream, Sparus aurata, in the Central Mediterranean Sea

In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available

2011-01-12

179

British Library Electronic Table of Contents (United Kingdom)

The gilthead seabream, Sparus aurata, represents an important economic resource for Mediterranean aquaculture. In spite of its wide geographic distribution and economic importance, only recently studies have been carried out on the genetic composition of natural populations, which have revealed a picture of a heterogeneous degree of genetic differentiation among S. aurata populations. In this study an allozyme analysis of samples from six different collecting sites along the Italian and Croatian coasts was carried out, covering an area in the Central Mediterranean sea that has yet to be investigated through gene-enzyme systems. Data on 26 gene loci, 10 of which are polymorphic, indicate a slight but significant genetic structure (FST = 0.0167) of the species. A hierarchical analysis of pop...

2006-01-01

180

Genetic Architecture Underlying Variation in Extent and Remodeling of the Collateral Circulation

GENETIC STUDIES OF PIGMENTATION IN ...

RationaleCollaterals are arteriole-to-arteriole anastomoses that connect adjacent arterial trees. They lessen ischemic tissue injury by serving as endogenous bypass...Full Text Available

2010-08-20

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

181

Estimation of Genetic Parameters for Growth-Related Traits in 9-month Old of Two Korean Abalone Subspecies, Haliotis discus hannai and H. discus discus, by Using Multiple Traits of Animal Model

... Strains Smith and -aybush were both grown in broth containing from 0.1 to 50 pg/ml of acriflavin, acridine orange, or proflavin. ...

1966-05-01

182

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model

Full Text Available

2009-12-01

183

Distinct sensory representations of wind and near-field sound in the Drosophila brain

BackgroundMutations that disrupt the conversion of prelamin A to mature lamin A cause the rare genetic disorder Hutchinson-Gilford progeria syndrome and a group of laminopathies....Full Text Available

184

Current Projects - Human Nutrition Research Center on Aging ...

Behavioral responses to wind are thought to play a critical role in controlling the dispersal and population genetics of wild Drosophila species1,Full Text Available

2009-03-12

185

diet and genetic obesity metabolic defects and inflammation. To determine the role of adipocyte death in promoting adipose tissue inflammation and insulin resistance in animal...

2011-08-31

186

Culture and cooperation

Consumer attitudes and decision-making with regard to genetically engineered food products: A review of the literature and a presentation of models for future research

Does the cultural background influence the success with which genetically unrelated individuals cooperate in social dilemma situations? In this paper, we provide an answer by analysing the data of Full Text Available

2010-09-12

187

Comparing Genomes within the Species Mycobacterium tuberculosis

Executive summary 1. Few studies have to date explained consumer attitudes and purchase decisions with regard to genetically engineered food products. However, the increased marketing of genetically engineered food products and the considerable concern that consumers seem to express with regard to the technology call for the development of a theoretical basis for research into these issues. 2. The aim of the paper is to present three models which we have developed to explain consumer attitudes, buying behaviour and attitude change with regard to genetically engineered food products. All three models build on established consumer behaviour theory and on existing and comparable research in the field. 3. Consumer attitudes toward genetic engineering in food products are explained in an attitude model that builds on Fishbein's multiattribute attitude model. The model deviates from Fishbein's model in a ...

1998-01-01

188

Combining Genetics and Population History in the Study of Ethnic Diversity in the People's Republic of China

The study of genetic variability within natural populations of pathogens may provide insight into their evolution and pathogenesis. We used a Mycobacterium tuberculosis high-density...Full Text Available

2001-04-01

189

Can microRNAs act as biomarkers of aging?

... some Central Asian populations (Zerjal et al. 2002). Haplogroup W has a similar Middle Eastern origin, and again ... ...

190

AEC syndrome - Genetics Home Reference

Aging can be defined as a progressive decline in physiological efficiency regulated by an extremely complex multifactorial process. The genetic makeup of an individual appears to dictate this rate...Full Text Available

191

Reasons for decision in the matter of TransCanada PipeLines Limited

What genes are related to AEC syndrome? AEC syndrome is caused by mutations in the TP63 gene. This gene provides instructions for making a protein known as p63, which plays an...

2011-10-15

192

Univ.) Uoclas - NASA Technical Report Server (NTRS)

TransCanada Pipelines Limited submitted an application to the National Energy Board for new facilities to increase natural gas deliveries to its domestic and export markets. The proposed facilities consist of 1,590 km of pipeline, 21 new compressor units and two new compressor stations. The total cost of the facilities was estimated at $2,408 million. The Board considered at the hearing 15 applications made pursuant to Part IV of the National Energy Board Act for gas exports at existing delivery points at Emerson and Niagra Falls as well as at proposed new delivery points at Chippawa and Iroquois, Ontario. Twelve of these applications were filed in support of TransCanada's facilities application. Five applications were also filed pursuant to section 71 of the National Energy Board Act for orders requiring TransCanada to receive, transport and deliver natural gas offered by the applicants and to provide adequate and ...

1991-04-01

193

The Importance of Mitochondrial DNA in Aging and Cancer

implications for treatment. In M.A. Chesney 8,. R. H. Rosenman (Eds.) Anqer and hostility in cardiovascular and behavioral disorders (pp. 103-126). ...

194

The Implications of Healthcare Utilization of Diabetes Disease ...

Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue...Full Text Available

195

The Canonical Seyfert Spectrum: The Implications of OSSE ...

... system. Perspective in Health Information Management, 1(4), 1-11. National Coalition on Healthcare. (2007). Health Insurance Coverage. ...

2008-06-24

196

Skin as an endocrine organ: implications for its function

... In a HEAO 1 study of active galaxies, principally Seyfert 1s, in the 2, 165 keV energy range, Rothschild et al. ... As discussed by Rothschild et al. ...

2011-05-14

197

Pulsational instability in massive stars: implications for ...

Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range...Full Text Available

2008-06-01

198

Possible Implications of Placental Expressions for Heat Shock Protein 70 and Lectin-like Oxidized Low Density Lipoprotein Receptor-1 on Postnatal Blood Pressure in Their Newborns

sive star evolution based on our new calculations of this pulsational instability, where the initial mass of SNe progenitors increases according to the ...

199

Phenomenological implications of three-generation heterotic string models

Full Text Available

2007-09-01

200

Newer molecules in the treatment of schizophrenia: A clinical update

This dissertation is devoted to the study of the phenomenological consequences of the three-generation heterotic string models based on the Calabi-Yau compactifications and the N = 2 superconformal constructions.

1992-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

201

Impact of associated injuries in the Floating knee: A retrospective study

Schizophrenia is a heterogeneous psychiatric disorder in which multiple neurotransmitter systems have been implicated. Increased and decreased dopamine transmission in the subcortical meso-limbic and...Full Text Available

2011-04-01

202

FIRST Workshop Presentation Abstract: Circumstellar Matter Around ...

BackgroundFloating knee injuries are usually associated with other significant injuries. Do these injuries have implications on the management of the floating knee and the final...Full Text Available

203

Expression and regulation of the NALP3 inflammasome complex in periodontal diseases

and the implications for massive star evolution. In recent years, the complex nature of the circumstellar regions of evolved massive stars has become apparent. ...

204

Deforestation: Much Ado about the Contribution to ... - Blogs - NASA

Periodontitis is an infectious process characterized by inflammation affecting the supporting structures of the teeth. Porphyromonas gingivalis is a major oral bacterial species implicated...Full Text Available

2009-09-01

205

Control of Host Cell Phosphorylation by Legionella Pneumophila

Jan 7, 2010 ... Deforestation. The environmental implications of the word are as numerous as the syllables. And scientists like Jim Collatz have the job of ...

206

Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited

Phosphorylation is one of the most frequent modifications in intracellular signaling and is implicated in many processes ranging from transcriptional control to signal transduction in innate immunity....Full Text Available

207

Clinical significance of coagulase-negative staphylococci.

The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's...Full Text Available

2010-07-15

208

Although coagulase-negative staphylococci (C-NS) have been implicated in certain human infections, they are generally regarded as contaminants, and their clinical significance is questioned. To assess...Full Text Available

1982-08-01

209

Big bang nucleosynthesis

Association and expression study of synapsin III and schizophrenia

A brief review of standard big bang nucleosynthesis theory and the related observations of the light element isotopes is presented. Implications of BBN on chemical evolution and constraints on particle properties will also be discussed.

2000-01-01

210

Asia's New High Tech Competitors

The synapsin III gene, SYN3, which belongs to the family of synaptic vesicle-associated proteins, has been implicated in the modulation of neurotransmitter...Full Text Available

2009-11-20

211

Antioxidents and the costs of egg production: Studies in the Green Turtle (Chelonoa mydas)

Implications for the United States Last modified on September 13,1995. Please send questions and/or comments about these pages to srsweb@nsf.gov.

212

Environmental Research Database

DescriptionThis Studentship will focus on the implications of material nutrition and health for reproduction in green turtles, and specifically the role played by dietary carotenoids.

2009-01-30

213

Negotiated settlements with a cost of service backstop: The consequences for depreciation

Green Building. Sustainable building in the USA and Canada; Green Building. Duurzaam bouwen in de VS en Canada

The movement from traditional regulatory hearings to negotiated settlements represents both a departure from cost of service regulation and a relaxation of regulatory oversight. Under negotiation parties are able to renegotiate inclusions in their cost of service while simultaneously creating a profit margin for the regulated firm where none existed under the cost of service outcome of a traditional hearing. This paper constructs a model to illustrate the existence of positive gains to pipeline and shipper from the re-allocation of expenses through time in the regulated pipeline services market in Canada. Behaviour consistent with the model is observable in anecdotal and econometric evidence gathered from the library of the National Energy Board of Canada, responsible for pipeline toll regulation in Canada. Empirical investigation by into settlement procedures in the Florida electricity market reveals similar findings; ...

2011-03-01

214

CANDU 9 - the CANDU product to meet customer and regulator requirements now and in the future

First, attention is paid to the development and use of new construction techniques, including the use of new building materials, e.g. synthetic materials and the so-called steel frame method. Next, the reduction of the energy consumption during the service life of a house is discussed. The reduction can be realized by means of passive methods, e.g. improved windows, thermal insulation and design, or by means of active methods, e.g. electric load monitoring. The information in this article mainly concerns the housing construction in the USA and Canada. The purpose of this article to contribute to the discussion in the Netherlands on innovation in the building technology, e.g. formulated in the report `Bouwvisie 2010` (Vision on Buildings for the year 2010) of the Dutch Advisory Board Technology Policy for the Building Industry (ARTB, abbreviated in Dutch) and the building technology policy of the Dutch Ministry of Economic Affairs (EZ). 4 figs., 2 tabs., 23 refs.

1996-12-31

215

CANDU 9 - the CANDU product to meet customer and regulator requirements now and in the future

CANDU reactors developed under Canadian licensing regulations that placed the primary responsibility for safety on the licensee. The Atomic Energy Control Board (AECB), Canada's nuclear regulatory agency, state in their regulations what is expected in terms of safety performance so that designers are free to propose the best means of meeting this performance. This goal-oriented approach, besides encouraging innovation, allowed CANDU to be licensed in other jurisdictions. The latest design - the large, single unit, CANDU 9 - explicitly incorporates licensability in Canada through a formal AECB review of the design; lessons learned from licensing CANDU 6 in Asian countries, particularly with Wolsong 2, 3 and 4 in Korea, and more recently with Qinshan in China; utility requirements for modem evolutionary plants; and emerging international standards for safety, sponsored or issued by the IAEA. By combining the assurance of acceptability in ...

1998-07-01

216

Transformed Governance and the Education for All-Fast Track Initiative. Policy Brief 2010-02

CANDU reactors developed under Canadian licensing regulations that placed the primary responsibility for safety on the licensee. The Atomic Energy Control Board (AECB), Canada's nuclear regulatory agency, state in their regulations what is expected in terms of safety performance so that designers are free to propose the best means of meeting this performance. This goal-oriented approach, besides encouraging innovation, allowed CANDU to be licensed in other jurisdictions. The latest design - the large, single unit, CANDU 9 - explicitly incorporates licensability in Canada through a formal AECB review of the design; lessons learned from licensing CANDU 6 in Asian countries, particularly with Wolsong 2, 3 and 4 in Korea, and more recently with Qinshan in China; utility requirements for modem evolutionary plants; and emerging international standards for safety, sponsored or issued by the IAEA. By combining the assurance of acceptability in ...

1998-05-03

217

Oil shales of the Stellarton Basin, Nova Scotia, Canada; Stratigraphy, depositional environment, composition and potential uses

The Education for All-Fast Track Initiative (FTI) grew out of the "New Focus on Education for All" communique of the G-8 when Canada hosted the summit in 2002 at Kananaskis. As Canada prepares again to host the G-8, and Korea assumes leadership of the newly-empowered G-20, it is a valuable moment to revisit and re-think the current global education architecture. By adopting some of the recommendations from the recent independent evaluation of the FTI and borrowing some lessons from global partnerships in other sectors, the FTI could set a new course toward the achievement of universal basic education. The FTI should broaden and strengthen the role of diverse stakeholders from developing countries and civil society in its governance structure in order to fully harness the energies of these stakeholders in resource mobilization and effective implementation. (Contains 9 endnotes.)

2010-05-01

218

The fault-bounded Stellarton Basin of northern Nova Scotia, Canada, contains the Province's largest oil shale resources (estimated at 825 {times} 10{sup 6} tons with 168 {times} 10{sup 6} bbls of shale oil in situ). The oil shales were first discovered in the 1850s and, except for limited scale mining during 1852-1859 and 1929-1930, they have remained undeveloped. In order to assess the potential economic use of the oil shales, a comprehensive study incorporating geological field mapping, core-logging, organic and inorganic geochemistry, organic petrology and combustion performance testing was undertaken. Results are presented.

1989-01-01

219

Korea's Team CANDU

Influence of migrant tundra swans (Cygnus columbianus) and Canada geese (Branta canadensis) on aquatic vegetation at Long Point, Lake Erie, Ontario

KEPCO (Korean Electric Power Corp.) with the support of AECL and other Korean and Canadian subcontractors has created a strong multi-company team to execute design and construction of the Wolsung-2 CANDU 6 power plant. Key concepts of the project team are: 1. KEPCO is the project manager, and AECL is the major engineering and supply contractor; 2. Significant participation by Korean companies in design work in Canada and Korea; 3. Significant manufacturing in both Canada and Korea; 4. Construction by Korean contractors. Key concepts of the Wolsung 2 design are: 1. Evolutionary improvement of the Wolsung-1 plant which balances proven technology and necessary design improvements including current codes and standards. 2. Sharing some structures with the Wolsung-1 plant. This paper describes the successful establishment and operation of the complex project interfaces along with the current project status and plans.

1992-06-07

220

British Library Electronic Table of Contents (United Kingdom)

Numerous studies have shown that large, herbivorous waterfowl can reduce quantity of aquatic plants during the breeding or wintering season, but relatively few document herbivory effects at staging areas. This study was done to determine if feeding activities of tundra swans (Cygnus columbianus columbianus) and Canada geese (Branta canadensis) had a measurable additive influence on the amount of aquatic plants, primarily muskgrass (Chara vulgaris), wild celery (Vallisneria americana), and sago pondweed (Potamogeton pectinatus), removed during the fall migration period at Long Point, Lake Erie, Ontario. Exclosure experiments done in fall 1998 and 1999 showed that, as compared to ducks and abiotic factors, these two large herbivorous waterfowl did not have any additional impact on above or b...

2006-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

A decade of petroleum developments

Quantitative genetic activity graphical profiles for use in chemical evaluation

Canada's offshore Atlantic petroleum industry is celebrating its tenth anniversary in 2001. This article chronicles the development of the industry discussing the many challenges and setbacks and the eventual triumphs that accompanied the industry's development over the years. Highlights discussed include shipping first oil from the Cohasset Field in July 1992; the financial crisis caused by the withdrawal of Gulf Oil from the Hibernia consortium in the same year; new funding and the beginning of the gravity-based structure construction at Bulls Arm in 1993; striking oil in the Hibernia Field in 1994; the start of exploration and development of the Terra Nova field by Petro-Canada in the same year, based on the floating production, storage and offloading (FPSO) system, which heralded a new era of offshore development in eastern Canada. Approval by the Nova Scotia government of the third and final phase of ...

2001-03-01

222

Optimal selection of capacitors for radial distribution systems using a genetic algorithm

A graphic approach, terms a Genetic Activity Profile (GAP), was developed to display a matrix of data on the genetic and related effects of selected chemical agents. The profiles provide a visual overview of the quantitative (doses) and qualitative (test results) data for each chemical. Either the lowest effective dose or highest ineffective dose is recorded for each agent and bioassay. Up to 200 different test systems are represented across the GAP. Bioassay systems are organized according to the phylogeny of the test organisms and the end points of genetic activity. The methodology for producing and evaluating genetic activity profile was developed in collaboration with the International Agency for Research on Cancer (IARC). Data on individual chemicals were compiles by IARC and by the US Environmental Protection Agency (EPA). Data are available on 343 compounds selected from volumes 1-53 of the IARC ...

1990-06-27

223

Nucleotide sequence and genetic analysis of a 13.1-kilobase-pair Pseudomonas denitrificans DNA fragment containing five cob genes and identification of structural genes encoding Cob(I)alamin adenosyltransferase, cobyric acid synthase, and bifunctional cobinamide kinase-cobinamide phosphate guanylyltransferase.

In this paper, a new design methodology for determining the size, location, type and number of capacitors to be placed on a radial distribution system is presented. The objective is to minimize the peak power losses and the energy losses in the distribution system considering the capacitor cost. A sensitivity analysis based method is used to select the candidate locations for the capacitors. A new optimization method using a Genetic Algorithm is proposed to determine the optimal selection of capacitors. Test results have been presented along with the discussion of the algorithm.

1994-08-01

224

Mobilization of the genetically engineered plasmid pHSV106 from Escherichia coli HB101(pHSV106) to Enterobacter cloacae in drinking water.

A 13.1-kb DNA fragment carrying Pseudomonas denitrificans cob genes has been sequenced. The nucleotide sequence and genetic analysis revealed that this fragment contained five different cob genes named...Full Text Available

1991-10-01

225

Liposome technology. Volume II: Incorporation of drugs, proteins and genetic material

We have used triparental matings to demonstrate transfer (mobilization) of the nonconjugative genetically engineered plasmid pHSV106, which contains the thymidine kinase gene of herpes simplex virus...Full Text Available

1991-01-01

226

Invasiveness and persistence of Salmonella enteritidis, Salmonella typhimurium, and a genetically defined S. enteritidis aroA strain in young chickens.

These three volumes cover liposome technology in pharmacology and medicine. Contributors emphasize methodology used in their own laboratories, and include a brief introduction, coverage of relevant literature, applications and critical evaluations for the methods they describe. Volume II presents procedures for the entrapment of a number of drugs, including genetic material, into selected types of liposomes.

1984-01-01

227

Genetics and biochemistry of Clostridium relevant to development of fermentation processes

Newly hatched chicks were dosed orally with a Salmonella typhimurium wild-type strain, an S. enteritidis wild-type strain, and a genetically defined S. enteritidis aroA vaccine candidate, strain CVL30....Full Text Available

1994-11-01

228

Genetic and somatic effects in animals maintained on tritiated water

It is the purpose of this review to draw together the recent research adding to our understanding of the molecular nature of Clostridia. The thrust here is to emphasize those research advances in biochemistry and genetics that bear upon future development of fermentation processes employing the Clostridia. 222 refs., 10 figs., 5 tabs.

1984-01-01

229

Generalized genetic code. A note on order-isomorphism/order-equivalence relations

The possible genetic (dominant lethal mutations (DLM) and cytogenetic changes in the regenerating liver) and somatic (hematopoietic stem cell changes, growth and nonspecific life time shortening) effects in mice maintained on tritiated water (HTO) over two generations was investigated. Results to date are summarized. (ACR)

1981-01-01

230

Estimation of organ dose during radiological and computer tomographic examinations with calculations of the somatically significant doses

Constructive and combinatorial relationships between order-isomorphisms and order-equivalence classes within the generalized genetic code are presented, not only for the biologically relevant groups of order 4, but also for finite groups of arbitrary order. The main result is the derivation of the number (and types) or order-equivalence classes for a group of order n. Finally, an extension of this work to all biologically admissible alternative codes is discussed.

1982-01-01

231

Estimation of organ dose during radiological and computer tomographic examinations with calculations of the somatically significant doses

The risks from radiation exposure during radiological diagnosis has usually been estimated in relation to genetic changes. Relevant information has been expressed as the genetically significant dose. In this paper we attempt to produce an analogous measure for evaluating the somatic risk in the form of a somatically significant dose index for radiological and CT examinations. It is shown that, for both types of examination, the two risk factors may be entirely different.

1980-10-01

232

Biological effects and health risks following to the exposition to ionizing radiation

The risks from radiation exposure during radiological diagnosis has usually been estimated in relation to genetic changes. Relevant information has been expressed as the genetically significant dose. In this paper we attempt to produce an analogous measure for evaluating the somatic risk in the form of a somatically significant dose index for radiological and CT examinations. It is shown that, for both types of examination, the two risk factors may be entirely different. (orig.).

1980-01-01

233

A Genetic Screen for Ribosomal DNA Silencing Defects Identifies Multiple DNA Replication and Chromatin-Modulating Factors

Late somatic and genetic radiation effects are imperfectly understood, particularly in the human species. However the available information is sufficient to draw reasonably precise risk estimates in man for many types of damage by means of scientifically justifiable procedures and with the necessary caution. This overall absolute risk of major somatic and genetic damage may be set at around 10"-"4/rad of chronic whole-body doses.

1976-01-01

234

Genetic studies of fertility and pathogenicity in Magnaporthe grisea (Pyricularia oryzae)

Transcriptional silencing in Saccharomyces cerevisiae occurs at several genetic loci, including the ribosomal DNA (rDNA). Silencing at telomeres (telomere position effect [TPE])...Full Text Available

1999-04-01

235

Genetic diversity associated with in vitro and conventional bud propagation of Saccharum varieties using RAPD analysis

Crosses between field isolates of Magnaporthe grisea (anamorph, Pyricularia oryzae Cav. and Pyricularia grisea) have led to the development of fertile laboratory strains that infect goosegrass and/or weeping lovegrass. These strains may now be utilized in a rigorous genetic analysis of host species specificity and general pathogenicity. Attempts to improve the fertility of rice pathogens for the goal of undertaking a genetic analysis of host cultivar specificity have so far been unsuccessful. Crosses between M. grisea strains that infect rice, goosegrass or weeping lovegrass demonstrate that host species specificity differences between field isolates of this fungus in some cases have a complete genetic basis, and in other cases have a simple genetic basis. Crosses between a field isolate of the pathogen that infects weeping lovegrass and a field isolate that infects goosegrass have resulted in the ...

1984-01-01

236

British Library Electronic Table of Contents (United Kingdom)

Abstract Polymorphisms in the genomic DNA of eight varieties maintained by conventional bud propagation (via rhizomes) and by in vitro shoot tip cultures were detected by RAPD analysis of sugarcane varieties. The study estimated the genetic diversity induced after in vitro multiplication of these varieties. Higher (28.9%) and lower (12%) numbers of polymorphic bands were detected in plants propagated via rhizomes; the genetic similarity estimate varying from 0.63 to 0.80. Plants of SP90-3723 and SP91-1049, or RB85-5113 and SP90-3723, varieties involving greater genetic distances may be indicated as progenitors in breeding programmes. In vitro multiplication of RB86-7515, RB85-5113, RB83-5054 and SP86-42 varieties increases genetic variability, while in vitro multiplication of SP91-1049, SP...

2008-01-01

237

The preservation of a cadaver by a clay sealant: Implications for the disposal of nuclear fuel waste

(WATER)Manufactured Nanoparticles: Assessing the Mobility of a Future Class of Contaminant in Groundwaters

This report documents a case history in which a cadaver and the associated burial objects were found well preserved after being buried for more than 2100 years in Southern China. The preservation is attributed to a layer of kaolin that surrounded the coffin and served as a barrier to water and air movement. The implications for the disposal of nuclear fuel waste are discussed.

238

Environmental Research Database

DescriptionNanotechnology is rapidly expanding, and is forecast to become a trillion dollar industry in the near future. It is inevitable that as nanotechnology applications increase, increasing amounts of manufactured nanoparticles (mNPs) will be released into the environment. The environmental and human health implications of the release of most of the huge range of possible particle types are as yet largely unknown, but in the context of groundwaters, apart from implications for the drinking of contam [continued...

2014-01-30

239

Transmit-receive eddy current probes for heat exchanger inspection

The Atomic Energy Control Board criteria for identification and evaluation of fire hazards in nuclear power stations

This paper describes various eddy current probes, and their performance, which were developed at the Chalk River Laboratories of Atomic Energy of Canada. Included are probes for detecting defects at tubesheet regions in heat exchanger tubes, defects at expansion-transition regions in finned tubes, and defects in ferromagnetic tubes. All of these probes can be used with conventional commercially available instruments. (author).

1987-09-01

240

Submission to the Georges Bank Review Panel

This report presents criteria for the identification and evaluation of fire hazards in nuclear power stations. The report presents criteria that are consistent with the existing regulatory approach in Canada, and outlines engineering tools and analytical techniques currently available to deterministically analyse fire. The criteria presented cover the topics which should be included in a fire hazard analysis and provide details of each topic so that the accuracy of an analysis may be evaluated.

2000-12-10

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

Silicone-rubber washers soothe vibrating transmission lines

The Georges Bank, off southwestern Nova Scotia, is one of the most biologically productive continental shelf ecosystems in the world. It supports a wide diversity of species, including many seabirds. In 1988, federal and provincial legislation placed a moratorium on petroleum exploration and drilling on the Georges Bank, directing the ministers of Natural Resources Canada, and of the Nova Scotia Department of Natural Resources to make a decision regarding the moratorium by January 1, 2000. This report by the Ecology Action Centre (EAC) asks the Georges Bank Review Panel to recommend extending the moratorium on Georges Bank and adjacent areas until 2012, in part to match the American moratorium. Other reasons why the panel made this recommendation were explored. The principal reason is the EAC concern that when the moratorium is lifted, several oil and gas developments will proceed in this ecologically significant offshore area that could result in the loss of the ...

1999-01-01

242

Review of White Rose Benefits Plan and its application to the South White Rose extension tie-back

Silicone-rubber washers function as damping and articulating elements in cast-aluminum spacers that separate bundle subconductors in each phase of extra-high-voltage transmission lines. Spacer/dampers are located every 3 ft. along transmission lines on Canada's first operational 500 and 735 kV system.

1965-01-01

243

Reply to comments on the proposed on-road vehicle and engine emission regulations

In January 2001, Husky Oil Operations Limited (Husky), in joint-venture with Petro-Canada, submitted a Benefits Plan for the White Rose Development to the Canada-Newfoundland and Labrador Offshore Petroleum Board (C-NLOPB). It was prepared following the Canada-Newfoundland and Labrador Atlantic Accord Implementation Act and the Canada-Newfoundland and Labrador Atlantic Accord Implementation (Newfoundland) Act. In December 2001, the C-NLOPB approved the White Rose Benefits Plan. This document described the work that Husky proposes to undertake within its significant discovery license areas 1043 and 1044 for the development of the South White Rose Extension (SWRX) Tie-back to the White Rose Floating Production, Storage and Offloading (FPSO) vessel as it will require an amendment to the original White Rose Development Plan and is subject to the review and approval of the C-NLOPB. The statutory requirements ...

2006-09-15

244

Prevention and management of osteoporosis: consensus statements from the Scientific Advisory Board of the Osteoporosis Society of Canada. 3. Effects of ovarian hormone therapy on skeletal and extraskeletal tissues in women.

In February 2001, the Minister of Environment Canada outlined a series of measures to be implemented over the next decades to reduce emissions from vehicles, engines and fuels. The agenda includes the development of new regulations under the authority of Part 7, Division 5 of the Canadian Environmental Protection Act (CEPA) to align Canada's emission standards for on-road vehicles with those of the United States Environmental Protection Agency. This paper presents a detailed summary of comments received by the interested parties that appeared at a public consultation in November 2001 to discuss and raise issues about the proposed regulations. The parties that provided submissions included: governments; the vehicle and engine manufacturing industry; the oil industry; other groups of associations such as the Canadian Trucking Alliance, David Suzuki Foundation, and West Coast Environmental Law; and, five private individuals. The report ...

2002-12-01

245

P and e identification capabilities CAPRICE

OBJECTIVE: To present recent evidence on the use of ovarian hormone therapy (OHT) for osteoporosis and outline safe and effective regimens. OPTIONS: Estrogen alone, estrogen and progestins, progestins...Full Text Available

1996-10-01

246

Nova Scotia Research Foundation Corporation 1989/90 annual report. [Canada - Nova Scotia

The cosmic antiparticle ring imaging Cherenkov experiment (CAPRICE) flew on a stratospheric balloon 8-9 August 1994 over northern Canada and collected data for more than 21 hours with less than 5 g/cm{sup 2} of residual atmosphere. The instrument includes a solid radiator RICH detector and an electromagnetic calorimeter for particle identification in the magnetic spectrometer. Preliminary antiproton and positron identification capabilities are presented.

1995-09-01

247

Latest designs in coal slurry pipelining

The Nova Scotia Research Foundation Corporation was established in 1946 by the Province of Nova Scotia to use science and technology to assist in the economic development of Nova Scotia. Within the Applied Science Division of the Corporation, research and development programs in the area of coal and mineral technology have been undertaken. A brief description of two projects -- coal liquefaction and coal-water fuels, are reported.

1990-09-01

248

Hybrid electric vehicles TOPTEC

This paper reports a recent feasibility study of a scheme to transport thermal coal as a coal-water slurry by pipeline from Coalspur, Alberta to the west coast of Canada. The base case is for the transport of 10.2 million tons of coal annually, and an expanded case of 18.2 million tons is also considered. Coal would be drawn from 5 mines within a 16 km radius of Coalspur. Several different terminal layouts were considered.

1983-03-01

249

This one-day TOPTEC session began with an overview of hybrid electric vehicle technology. Updates were given on alternative types of energy storage, APU control for low emissions, simulation programs, and industry and government activities. The keynote speech was about battery technology, a key element to the success of hybrids. The TOPEC concluded with a panel discussion on the mission of hybrid electric vehicles, with a perspective from industry and government experts from United States and Canada on their view of the role of this technology.

1994-06-21

250

Getting gas to shore

Geology and coalbed methane potential of the foothills in the Cadomin area, Alberta. [Canada - Alberta

Calls for containers to transport compressed natural gas, and a ship or barge to house some 200 employees in the Terra Nova offshore oilfield while the oil field's floating production, storage and offloading (FPSO) system is undergoing a major overhaul, are attracting attention on Canada's east coast offshore oilpatch. The FPSO is located offshore, 350 km east of St. John's, Newfoundland. Petro-Canada, operators of the FPSO anticipate that by having all required personnel nearby, the total shutdown time for the overhaul could be minimized. The CNG container was designed by Trans Ocean Gas Inc. in response to an invitation by Husky Oil and Petro-Canada, the White Rose field partners. Trans Ocean Gas strongly believes that CNG will become the technology of choice for getting natural gas ashore and to markets from stranded hydrocarbon pools in Atlantic Canada and the rest of the ...

2004-10-01

251

Environmental and health effects of fossil fuel and nuclear power generation

The Cadomin area in Alberta contains two major coal mines and may be the site of Alberta's next new coal mine in the Coalspur Coalfield. No recent geological maps exist of the area. This paper details the methodology for mapping this heavily forested area. Coalbed methane potential is also discussed. 12 refs., 5 figs.

1992-01-01

252

Dissemination of Clonally Related Escherichia coli Strains Expressing Extended-Spectrum ?-Lactamase CTX-M-15

The objective of this study was to identify and assess the present and future dimensions of environmental effects and impacts of various energy generation alternatives, and to place safety and environmental risks associated with the nuclear industry in Canada in perspective with the risks from other sources. It was found that nuclear power generation involves a comparable risk to that of conventional methods of thermoelectric power generation.

1986-09-07

253

Comparison of a multivalent viral vaccine program versus a univalent viral vaccine program on animal health, feedlot performance, and carcass characteristics of feedlot calves

We analyzed 43 CTX-M-15–producing Escherichia coli isolates and 6 plasmids encoding the bla_CTX-M-15 gene from Canada, India, Kuwait, France, Switzerland,...Full Text Available

2008-02-01

254

Climate change, productivity shocks and demand for freight ground transportation in Atlantic Canada

A field study was conducted under commercial feedlot conditions at 2 sites in western Canada to determine the relative effects of a univalent viral vaccine (MLV 1) program versus a multivalent viral...Full Text Available

2003-01-01

255

Canadian natural gas winter 2006-07 outlook

A study was conducted to determine the impacts of climate change on the transportation sector in a regional context. The purpose was to analyze potential climate change impacts on demand for freight transportation in Atlantic Canada through its association with other sectors of the regional economy. Freight transportation is designed to meet transportation demands of commodity producers who must deliver their goods to final users. Since it is a by-product of profit maximization and cost minimization by producers of all types of commodities in various sectors of the economy, this study modelled climate change impacts as productivity shocks in relevant sectors of the economy. A computerized simulation was then used to determine how the consequences of these shocks influence the demand for freight transportation. This was accomplished by collecting climate related data in Atlantic Canada as well as aggregate economic data that reflects the ...

2005-05-08

256

What is the heritable component of spinal deformities in the European sea bass (Dicentrarchus labrax)?

This paper provided an outline of the Canadian natural gas commodity market and a forecast for Canadian natural gas supply and prices for the 2007 winter heating season. Since 2001, steady demand growth and slow supply growth have contributed to higher North American natural gas commodity prices. The loss of natural gas supply due to hurricanes pushed North American natural gas commodity prices to record levels in 2005. Canadian natural gas production levels currently exceed domestic gas consumption. In 2005, Canada produced 16.5 billion cubic feet per day of marketable natural gas. Approximately 45 per cent was consumed domestically, and the remainder was exported to the United States. Despite high levels of drilling activity, production of natural gas from western Canada has flattened out since 2001. In 2006, natural gas prices in Canada declined due to the restoration of United States Gulf Coast natural gas production; ...

257

British Library Electronic Table of Contents (United Kingdom)

Malformations in farmed fish are a prime research topic as it has a major impact on fish welfare and on the economical value of the product. In this study, the genetic component of spine deformities was estimated in European sea bass, a major species of Mediterranean aquaculture, with the use of a posteriori reconstruction of pedigree with microsatellites. Our population exhibited a very high malformation rate (81%), probably due to intense swimming of fish during pre-growing. The heritability of global spine deformities was evaluated to be 0.21?0.04 on the underlying scale (0.33?0.06 for lordosis, 0.13?0.04 for scoliosis). Deformities scored by an internal or external examination turned out to be genetically the same trait (genetic correlations>0.9), although phenotypic correlations were ...

2009-01-01

258

The ribosome and the mechanism of protein synthesis

Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OA

In virtually all forms of life on earth, proteins in each cell are made according to a genetic blueprint, in the form of DNA. The translation of copies of this genetic blueprint (in the form of messenger RNA) into polypeptides is performed on the ribosome, a highly complex molecular machine composed of RNAs and proteins. To this end, special adaptor molecules called transfer RNAs are lined up by the ribosome in the sequence dictated by the genetic code, such that the amino acids carried by these molecules can be linked into a polypeptide. Several cofactors are involved in these processes, some of which require energy freed up by GTP hydrolysis. Although the ribosome was discovered more than 50 years ago, its structure has only been solved recently by X-ray crystallography. Another technique, cryo-electron microscopy, is starting to contribute toward our understanding of the ribosome's function, by portraying its ...

2006-05-01

259

British Library Electronic Table of Contents (United Kingdom)

On November fourth and fifth 2010 a group of more than 100 international investigators gathered in Atlanta for the second Osteoarthritis (OA) Biomarkers Global Initiative workshop titled ''Genetics and Genomics: New Targets in OA''. The first workshop took place in April 2009 and focused on in vitro (soluble) biomarkers whilst the third and final workshop will take place in 2012 and will focus on imaging biomarkers. The OA Research Society International (OARSI) has organized the workshops. In addition to OARSI, the National Institute of Arthritis, Musculoskeletal and Skin Diseases, the Arthritis Foundation, Amgen, Genzyme, the American Orthopaedic Society for Sports Medicine and Pfizer sponsored the second meeting. It was clear from this meeting that experiments in the genetics, epigenetic...

2011-01-01

260

Predicting the subspecific identity of invasive species using distribution models: Acacia saligna as an example

British Library Electronic Table of Contents (United Kingdom)

Abstract Aim- To explore whether the subspecific genetic entities of Acacia saligna occupy different bioclimatic niches in their native and introduced ranges and whether these niches are predictable using species distribution models (SDMs). Location- Australia, South Africa and the Mediterranean Basin. Methods- Species distribution models were developed in MAXENT using six climatic variables to calculate the climatic suitability of the ranges of A.saligna. We assessed (1) the subspecific niche differences identified by SDMs using measures of niche overlap and model performance; (2) the ability of SDMs to predict the most likely subspecific genetic entities present in South Africa based on comparisons to genetic data; and (3) the ability of SDMs to predict the most likely subspecific geneti...

2011-01-01

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261

Molecular phylogeography of the microturbellarian Monocelis lineata (Platyhelminthes: Proseriata) in the North-East Atlantic

British Library Electronic Table of Contents (United Kingdom)

Monocelis lineata is a complex of cryptic species (three in the Mediterranean and one in the Atlantic) widespread in midlittoral habitats. Throughout the range, populations with or without an ocular pigmented shield are found. We investigated the genetic structure of the North-East Atlantic populations with the aim of shedding light on their phylogeography and reconstructing possible patterns of recolonization after the Wrmian glaciation. Fourteen samples were investigated using cytochrome c oxidase subunit I (COI) and 13 by inter-simple sequence repeats (ISSRs). COI did not exhibit a clear pattern of decreased genetic diversity along a latitudinal gradient. Populations from Ferrol (Spain), Doolin (Ireland), and Helsingr (Denmark) showed a higher genetic variability, whereas a reduction in...

2011-01-01

262

Incorporating Traditional Knowledge in an International Regime on Access to Genetic Resources and Benefit Sharing: Problems and Prospects

British Library Electronic Table of Contents (United Kingdom)

The Seventh Meeting of the Conference of the Parties (2004) of the Convention on Biological Diversity established a mandate for the negotiation of an international regime on Access to Genetic Resources and Benefit Sharing arising from their utilization. Negotiations have been proceeding and have entered the final phase. Seven working group meetings have been held to date and there is expectation that an instrument will emerge by the final deadline - the Tenth Meeting of the Conference of the Parties in Nagoya, Japan in October 2010. A key component singled out for inclusion in the international regime relates to the recognition and protection of the rights of indigenous and local communities (ILCs) over their traditional knowledge (TK) associated with genetic resources. The Ninth Meeting o...

2010-01-01

263

Human cDNA mapping using fluorescence in situ hybridization

Genetic fidelity of long-term micropropagated shoot cultures of vanilla (Vanilla planifolia Andrews) as assessed by molecular markers

Genetic mapping is approached using the techniques of high resolution fluorescence in situ hybridization (FISH). This technology and the results of its application are designed to rapidly generate whole genome as tool box of expressed sequence to speed the identification of human disease genes. The results of this study are intended to dovetail with and to link the results of existing technologies for creating backbone YAC and genetic maps. In the first eight months, this approach generated 60--80% of the expressed sequence map, the remainder expected to be derived through more long-term, labor-intensive, regional chromosomal gene searches or sequencing. The laboratory has made significant progress in the set-up phase, in mapping fetal and adult brain and other cDNAs, in testing a model system for directly linking genetic and physical maps using FISH with small fragments, in setting up a database, and in establishing the ...

1993-03-04

264

British Library Electronic Table of Contents (United Kingdom)

Occurrence of genetic variants during micropropagation is occasionally encountered when the cultures are maintained in vitro for long period. Therefore, the micropropagated multiple shoots of Vanilla planifolia Andrews developed from axillary bud explants established 10 years ago were used to determine somaclonal variation using random amplified polymorphic DNA (RAPD) and intersimple sequence repeats markers (ISSR). One thousand micro-plants were established in soil of which 95 plantlets (consisting of four phenotypes) along with the mother plant were subjected to genetic analyses using RAPD and ISSR markers. Out of the 45 RAPD and 20 ISSR primers screened, 30 RAPD and 7 ISSR primers showed 317 clear, distinct and reproducible band classes resulting in a total of 30 115 bands. However, no ...

2007-01-01

265

Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17

British Library Electronic Table of Contents (United Kingdom)

Obesity is associated with increased susceptibility to dyslipidemia, insulin resistance, and hypertension, a combination of traits that comprise the traditional definition of the metabolic syndrome. Recent evidence suggests that obesity is also associated with the development of nonalcoholic fatty liver disease (NAFLD). Despite the high prevalence of obesity and its related conditions, their etiologies and pathophysiology remains unknown. Both genetic and environmental factors contribute to the development of obesity and NAFLD. Previous genetic analysis of high-fat, diet-induced obesity in C57BL/6J (B6) and A/J male mice using a panel of B6-ChrA/J/NaJ chromosome substitution strains (CSSs) demonstrated that 17 CSSs conferred resistance to high-fat, diet-induced obesity. One of these CSS st...

2009-01-01

266

Genetic and environmental interactions determine plant defences against herbivores

British Library Electronic Table of Contents (United Kingdom)

Summary 1. Plants express multiple defensive traits, but little is known about the genetic stability and phenotypic plasticity of these traits in nature. To investigate sources of variation and their potential ecological consequences for herbivores, we combined field observations of cyanogenic lima bean with laboratory experiments. 2. Field studies in South Mexico revealed a distinct variability of cyanogenic traits within and among wild lima bean populations. To differentiate among genetic variation and the impact of ambient conditions on plant phenotypes, we used seed grown plants as well as clones propagated from high (HC) and low cyanogenic (LC) wild type plants. 3. In growth chamber experiments, we cultivated plants under three intensities each of drought and salt stress, nutrient sup...

2011-01-01

267

Genetic Variation of Lodgepole Pine, Pinus contorta var. latifolia, Chemical and Physical Defenses that Affect Mountain Pine Beetle, Dendroctonus ponderosae, Attack and Tree Mortality

British Library Electronic Table of Contents (United Kingdom)

Plant secondary chemistry is determined by both genetic and environmental factors, and while large intraspecific variation in secondary chemistry has been reported frequently, the levels of genetic variation of many secondary metabolites in forest trees in the context of potential resistance against pests have been rarely investigated. We examined the effect of tree genotype and environment/site on the variation in defensive secondary chemistry of lodgepole pine, Pinus contorta var. latifolia, against the fungus, Grosmannia clavigera (formerly known as Ophiostoma clavigerum), associated with the mountain pine beetle, Dendroctonus ponderosae. Terpenoids were analyzed in phloem samples from 887, 20-yr-old trees originating from 45 half-sibling families planted at two sites. Samples were coll...

2011-01-01

268

Estimates of quantitative genetic parameters of immunological traits in the chicken.

Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: A genetic analysis of comorbidity

Three in vivo assays were used to measure the immunocompetence of chickens in two generations of a selection experiment. The obtained data were used to estimate the variance components for sire and dam for antibody production to Pasteurella multocida and Mycoplasma gallisepticum vaccines, for T-cell-mediated immunity evaluated by a phytohemagglutinin wing web assay, and for clearance of foreign particles from the circulatory system. Heritabilities of and genetic correlations among these immunological traits were calculated from the sire variance components. Heritability estimates of the immunological traits based on the sire component of variance ranged from .06 to .53, and genetic correlations among immunological traits were generally negative. PMID:1956847

1991-10-01

269

British Library Electronic Table of Contents (United Kingdom)

Abstract Previous research has established the comorbidity of adult Attention-Deficit Hyperactivity Disorder (ADHD) with different personality disorders including Borderline Personality Disorder (BPD). The association between adult ADHD and BPD has primarily been investigated at the phenotypic level and not yet at the genetic level. The present study investigates the genetic and environmental contributions to the association between borderline personality traits (BPT) and ADHD symptoms in a sample of 7,233 twins and siblings (aged 18-90 years) registered with the Netherlands Twin Register and the East Flanders Prospective Twin Survey (EFPTS) . Participants completed the Conners' Adult ADHD Rating Scales (CAARS-S:SV) and the Personality Assessment Inventory-Borderline Features Scale (PAI-BO...

2011-01-01

270

Association between chemical and genetic variation in Calophyllum inophyllum, a medicinally important tree of the Western Ghats of India

British Library Electronic Table of Contents (United Kingdom)

The objective of the present work is to study the chemical variation in Calophyllum inophyllum growing along the Western Ghats of India. Contents of dipyranocoumarins (inophyllums) in C.?inophyllum were determined to assess whether they could be used as a taxonomic marker for C.?inophyllum. This study also aims to establish inter simple sequence repeat (ISSR) markers that can be used to study genetic variation within the species and explore correlation between ISSR and chemical markers. The contents of dipyranocoumarins were estimated in seeds collected from 20 locations. Leaves from plants at the same 20 locations were assayed for ISSR variation. A dendrogram based on Nei?s genetic distance as well as principal component analysis based on dipyranocoumarins and ISSR variation clustered pla...

2011-01-01

271

An integrated genome research network for studying the genetics of alcohol addiction

British Library Electronic Table of Contents (United Kingdom)

Abstract Alcohol drinking is highly prevalent in many cultures and contributes to the global burden of disease. In fact, it was shown that alcohol constitutes 3.2% of all worldwide deaths in the year 2006 and is linked to more than 60 diseases, including cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders, injuries and foetal alcohol syndrome. Alcoholism, which has been proven to have a high genetic load, is one potentially fatal consequence of chronic heavy alcohol consumption, and may be regarded as one of the most prevalent neuropsychiatric diseases afflicting our society today. The aim of the integrated genome research network -Genetics of Alcohol Addiction--which is a German inter-/trans-disciplinary life science consortium consisting of molecular biologists,...

2010-01-01

272

Martin Buber's philosophy of education and its implications for adult non-formal education

British Library Electronic Table of Contents (United Kingdom)

The Jewish philosopher and educator Martin Buber (1878-1965) is considered one of the twentieth century's greatest contributors to the philosophy of religion and is also recognized as the pre-eminent scholar of Hasidism. He has also attracted considerable attention as a philosopher of education. However, most commentaries on this aspect of his work have focussed on the implications of his philosophy for formal education and for the education of the child. Given that much of Buber's philosophy is based on dialogue, on community and on mutuality, it is puzzling that relatively little has been written on the implications of Buber's thought for the theory and practice of non-formal adult education. The article provides a discussion of the philosophy underpinning this aspect of Martin Buber's l...

2009-01-01

273

Large (≥2cm) non-hypervascular nodules depicted on MRI in the cirrhotic liver: fate and implications

British Library Electronic Table of Contents (United Kingdom)

Aim To determine the fate and clinical implication of large (?2cm), non-hypervascular nodules depicted on magnetic resonance imaging (MRI) in the cirrhotic liver. Materials and methods In 21 patients with cirrhosis (14 hepatitis B, two ethanol abuse, four cryptogenic, one Wilson's disease), 25 large (?2cm in the longest dimension) non-hypervascular nodules were identified on dynamic MRI. The implications for diagnosis of the initial size, contour, and signal characteristics on MRI in addition to patients' age and cause of cirrhosis were assessed in our analysis. Results Twelve (75%) out of 16 lesions were malignant or potentially-malignant from 14 hepatitis B patients, while seven (78%) of the nine lesions from other patients were benign (p=0.016). The mean age of the patients who ha...

2008-01-01

274

Early Language Learning and Literacy: Neuroscience Implications for Education

British Library Electronic Table of Contents (United Kingdom)

The last decade has produced an explosion in neuroscience research examining young children's early processing of language that has implications for education. Noninvasive, safe functional brain measurements have now been proven feasible for use with children starting at birth. In the arena of language, the neural signatures of learning can be documented at a remarkably early point in development, and these early measures predict performance in children's language and pre-reading abilities in the second, third, and fifth year of life, a finding with theoretical and educational import. There is evidence that children's early mastery of language requires learning in a social context, and this finding also has important implications for education. Evidence relating socioeconomic status (SES) ...

2011-01-01

275

solQTL: a tool for QTL analysis, visualization and linking to genomes at SGN database

Why is it getting more difficult to successfully artificially inseminate dairy cows?*

BackgroundA common approach to understanding the genetic basis of complex traits is through identification of associated quantitative trait loci (QTL). Fine mapping QTLs requires...Full Text Available

276

Variation in Nicotine Consumption in Inbred Mice Is Not Linked to Orosensory Ability

Successfully using artificial insemination (AI) is defined as getting cows pregnant when the farmer wants them in-calf and making the best use of appropriate genetic potential. Over the past...Full Text Available

2008-08-01

277

Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans

Genetic studies of nicotine addiction in mice have utilized the oral self-administration model. However, it is unclear if strain differences in nicotine consumption are influenced by variation in bitter...Full Text Available

2009-01-01

278

Type I Collagen Is a Genetic Modifier of Matrix Metalloproteinase 2 in Murine Skeletal Development

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers...Full Text Available

2011-04-01

279

Transposable elements in fish functional genomics: technical challenges and perspectives

Recessive inactivating mutations in human matrix metalloproteinase 2 (MMP2, gelatinase A) are associated with syndromes that include abnormal facial appearance, short stature, and severe bone...Full Text Available

2007-06-01

280

Transgenesis in Xenopus using the Sleeping Beauty transposon system

The recent introduction of several transposable elements in zebrafish opens new frontiers for genetic manipulation in this important vertebrate model. This review discusses transposable elements as...Full Text Available

2007-01-01

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281

The high Andes, gene flow and a stable hybrid zone shape the genetic structure of a wide-ranging South American parrot

Transposon-based integration systems have been widely used for genetic manipulation of invertebrate and plant model systems. In the past decade, these powerful tools have begun to be used in...Full Text Available

2009-07-01

282

The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN study*

BackgroundWhile the gene flow in some organisms is strongly affected by physical barriers and geographical distance, other highly mobile species are able to overcome such constraints....Full Text Available

283

The Spectrum of Monogenic Autoinflammatory Syndromes: Understanding Disease Mechanisms and Use of Targeted Therapies

Chronically elevated interleukin-6 (IL-6) affects lipid and lipoprotein metabolism. Individuals genetically predisposed to higher IL-6 secretion may be at risk of dyslipidemia, especially during the...Full Text Available

2008-08-01

284

The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific

Monogenic autoinflammatory diseases encompass a distinct and growing clinical entity of multisystem inflammatory diseases with known genetic defects in the innate immune system. The diseases...Full Text Available

2008-07-01

285

The Genetic Basis of Cellular Morphogenesis in the Filamentous Fungus Neurospora crassa

The world's oceans contain a complex mixture of micro-organisms that are for the most part, uncharacterized both genetically and biochemically. We report here a metagenomic study of the marine planktonic...Full Text Available

2007-03-01

286

The Dystrophin Complex Controls BK Channel Localization and Muscle Activity in Caenorhabditis elegans

Cellular polarity is a fundamental property of every cell. Due to their extremely fast growth rate (≥1 μm/s) and their highly elongated form, filamentous fungi represent a prime example...Full Text Available

2003-11-01

287

Temperature regulates limb length in homeotherms by directly modulating cartilage growth

Genetic defects in the dystrophin-associated protein complex (DAPC) are responsible for a variety of pathological conditions including muscular dystrophy, cardiomyopathy, and vasospasm. Conserved DAPC...Full Text Available

2009-12-01

288

Technical approaches for mouse models of human disease

Allen's Rule documents a century-old biological observation that strong positive correlations exist among latitude, ambient temperature, and limb length in mammals. Although genetic selection for thermoregulatory...Full Text Available

2008-12-09

289

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase

The mouse is the leading organism for disease research. A rich resource of genetic variation occurs naturally in inbred and special strains owing to spontaneous mutations. However, one can also obtain...Full Text Available

2011-05-01

290

Stressed-Induced TMEM135 Protein Is Part of a Conserved Genetic Network Involved in Fat Storage and Longevity Regulation in Caenorhabditis elegans

The development of new methods for gene addition to mammalian genomes is necessary to overcome the limitations of conventional genetic engineering strategies. Although a variety of DNA-modifying enzymes...Full Text Available

2011-09-01

291

Specific genetic modifications of domestic animals by gene targeting and animal cloning

Disorders of mitochondrial fat metabolism lead to sudden death in infants and children. Although survival is possible, the underlying molecular mechanisms which enable this outcome have not yet been...Full Text Available

292

Speciation genetics: current status and evolving approaches

The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large...Full Text Available

293

Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent

The view of species as entities subjected to natural selection and amenable to change put forth by Charles Darwin and Alfred Wallace laid the conceptual foundation for understanding speciation. Initially...Full Text Available

2010-06-12

294

Single nucleotide polymorphisms for assessing genetic diversity in castor bean (Ricinus communis)

SummarySoluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs). Genetic variations...Full Text Available

2009-03-01

295

Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes

BackgroundCastor bean (Ricinus communis) is an agricultural crop and garden ornamental that is widely cultivated and has been introduced worldwide. Understanding...Full Text Available

296

Sex modifies exercise and cardiac adaptation in mice

BackgroundRecent evidence suggests that some sex differences in brain and behavior might result from direct genetic effects, and not solely the result of the organizational effects...Full Text Available

297

Sex determines the expression level of one third of the actively expressed genes in bovine blastocysts

How an individual’s sex and genetic background modify cardiac adaptation to increased workload is a topic of great interest. We systematically evaluated morphological and physiological...Full Text Available

2004-12-01

298

Although genetically identical for autosomal Chrs (Chr), male and female preimplantation embryos could display sex-specific transcriptional regulation. To illustrate sex-specific differences at the...Full Text Available

2010-02-23

299

STR References 3001-3250

Root Suberin Forms an Extracellular Barrier That Affects Water Relations and Mineral Nutrition in Arabidopsis

Journal of Human Genetics. 82: 873-882. 3134. Schulz, I., Schneider, P. M., Olek, K, Rothschild, M. A., and Tsokos, M. (2006) Examination of Postmortem Animal Interference to Human...

2009-03-16

300

Role of the nac gene product in the nitrogen regulation of some NTR-regulated operons of Klebsiella aerogenes.

Though central to our understanding of how roots perform their vital function of scavenging water and solutes from the soil, no direct genetic evidence currently exists to support the foundational model...Full Text Available

2009-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Remobilization of Tol2 transposons in Xenopus tropicalis

A positive, genetic selection against the activity of the nitrogen regulatory (NTR) system was used to isolate insertion mutations affecting nitrogen regulation in Klebsiella aerogenes. Two classes...Full Text Available

1990-12-01

302

Research - Keyword Index

Wastenet

...and biological processes acting on recruitment and post-recruitment EU-Agrinet - Project sheet: Biological performance testing methodology to evaluate the durability of plywood as a quality indicator ... Project sheet: Biological performance testing methodology to evaluate the durability of plywood as a quali EU-Agrinet - Project sheet: Genetic evaluation of European ...

303

Regulation of G1 Cell Cycle Progression

BackgroundThe Class II DNA transposons are mobile genetic elements that move DNA sequence from one position in the genome to another. We have previously demonstrated that the naturally...Full Text Available

304

Recovery of Pathogenic Measles Virus from Cloned cDNA

Most genetic changes that promote tumorigenesis involve dysregulation of G1 cell cycle progression. A key regulatory site in G1 is a growth factor–dependent restriction point (R) where cells...Full Text Available

2010-11-01

305

Reconstructing Mammalian Phylogenies: A Detailed Comparison of the Cytochrome b and Cytochrome Oxidase Subunit I Mitochondrial Genes

Reverse genetics technology so far established for measles virus (MeV) is based on the Edmonston strain, which was isolated several decades ago, has been passaged in nonlymphoid cell lines, and is no...Full Text Available

2000-07-01

306

Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein.

The phylogeny and taxonomy of mammalian species were originally based upon shared or derived morphological characteristics. However, genetic analyses have more recently played an increasingly important...Full Text Available

307

Radiation exposure due to X-rays of the hip joint in babies

Apolipoprotein (apo) A-IV is a polymorphic, intestinally derived apolipoprotein that is genetically linked to and similar in structure to apoA-I, the major apolipoprotein in high density lipoproteins...Full Text Available

1993-08-01

308

QSAR Studies of Copper Azamacrocycles and Thiosemicarbazones

Exact anatomic knowledge about the location of the gonads and the application of corresponding measures of radiation protection are the preconditions for an efficient reduction of the danger of a possible genetic damage as a result of radiation exposition during X-ray examination of the hip joint of newborns. (VJ).

309

Public interest in predictive genetic testing, including direct-to-consumer testing, for susceptibility to major depression: preliminary findings

Genetic algorithms (GA) were used to develop specific copper metal-ligand force field parameters for the MM3 force field, from a combination of crystallographic structures and ab initio...Full Text Available

2005-08-25

310

Programmed Cell Death during Pollination-Induced Petal Senescence in Petunia1

The past decade has seen rapid advances in the identification of associations between candidate genes and a range of common multifactorial disorders. This paper evaluates public attitudes towards the...Full Text Available

2010-01-01

311

Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error

Petal senescence, one type of programmed cell death (PCD) in plants, is a genetically controlled sequence of events comprising its final developmental stage. We characterized the pollination-induced...Full Text Available

2000-04-01

312

Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens

BackgroundWith the advent of increasingly efficient means to obtain genetic information, a great insurgence of data has resulted, leading to the need for methods for analyzing this...Full Text Available

313

Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice

Plasmodium falciparum, the causative agent of human malaria, invades host erythrocytes using several proteins on the surface of the invasive merozoite, which have been proposed...Full Text Available

2010-03-01

314

Phylogenetic Network for European mtDNA

Insulin resistance plays a central role in type 2 diabetes and obesity, which develop as a consequence of genetic and environmental factors. Dietary changes including high fat diet (HFD) feeding promotes...Full Text Available

315

Persistent Staphylococcus aureus Colonization Is Not a Strongly Heritable Trait in Amish Families

The sequence in the first hypervariable segment (HVS-I) of the control region has been used as a source of evolutionary information in most phylogenetic analyses of mtDNA. Population genetic inference...Full Text Available

2001-06-01

316

Pathophysiological, Genetic and Gene Expression Features of a Novel Rodent Model of the Cardio-Metabolic Syndrome

About 20% of adults are persistently colonized with S. aureus in the anterior nares. Host genetic factors could contribute susceptibility to this phenotype. The objective of...Full Text Available

317

Parent-of-origin effects on voluntary exercise levels and body composition in mice

BackgroundComplex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models.Methodology/Principal...Full Text Available

318

PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah^enu2 mice

Despite the health-related benefits of exercise, many people do not engage in enough activity to realize the rewards, and little is known regarding the genetic or environmental components that account...Full Text Available

2010-01-01

319

Olfactory copy number association with age at onset of Alzheimer disease

Phenylketonuria (PKU) is a common genetic disorder in humans that arises from deficient activity of phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine....Full Text Available

2007-01-05

320

Oil palm (Elaeis guineensis Jacq.) tissue culture ESTs: Identifying genes associated with callogenesis and embryogenesis

Objectives:Copy number variants (CNVs) have been recognized as a source of genetic variation that contributes to disease phenotypes. Alzheimer disease (AD) has high heritability...Full Text Available

2011-04-12

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Nuclear reprogramming in mammalian somatic cell nuclear cloning

BackgroundOil palm (Elaeis guineensis Jacq.) is one of the most important oil bearing crops in the world. However, genetic improvement of oil palm through conventional...Full Text Available

322

Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina

Nuclear cloning is still a developing technique used to create genetically identical animals by somatic cell nuclear transfer into unfertilized eggs. Despite an intensive effort in a number...Full Text Available

2004-01-01

323

Novel Multilocus Measure of Linkage Disequilibrium to Estimate Past Effective Population Size

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated...Full Text Available

324

Myofibrillogenesis in the developing zebrafish heart: A functional study of tnnt2

Linkage disequilibrium (LD) between densely spaced, polymorphic genetic markers in humans and other species contains information about historical population size. Inferring past population size is of...Full Text Available

2003-04-01

325

Mycolic Acid Analysis by High-Performance Liquid Chromatography for Identification of Mycobacterium Species

Various hypotheses have been proposed to explain the molecule processes of sarcomere assembly, partially due to the lack of systematic genetic studies of sarcomeric genes in an in vivo...Full Text Available

2009-07-15

326

Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins.

Mycobacterium tuberculosis is the etiologic agent of tuberculosis and can be accurately detected by laboratories using commercial genetic tests. Nontuberculosis mycobacteria (NTM) causing other mycobacterioses...Full Text Available

2001-10-01

327

Mutation analysis of 272 Spanish families affected by autosomal recessive retinitis pigmentosa using a genotyping microarray

In our quest for novel genes required for the development of the embryonic peripheral nervous system (PNS), we have performed three genetic screens using MAb 22C10 as a marker of terminally differentiated...Full Text Available

2000-12-01

328

Multivariate analyses reveal common and drug specific genetic influences on responses to four drugs of abuse

PurposeRetinitis pigmentosa (RP) is a genetically heterogeneous disorder characterized by progressive loss of vision. The aim of this study was to identify the causative mutations...Full Text Available

329

Molecular mechanisms of genetic adaptation to xenobiotic compounds.

Vulnerability to abused drugs is influenced by multiple genes unique to each drug as well as to risk genes for polydrug abuse. If several inbred mouse strains respond to different drugs similarly,...Full Text Available

2008-11-01

330

Molecular biological enhancement of coal biodesulfurization. Final report, October 1988--December 1991

Microorganisms in the environment can often adapt to use xenobiotic chemicals as novel growth and energy substrates. Specialized enzyme systems and metabolic pathways for the degradation of man-made...Full Text Available

1992-12-01

331

Mobilizing diversity: transposable element insertions in genetic variation and disease

The overall objective of this project was to use molecular genetics to develop strains of bacteria with enhanced ability to remove sulfur from coal, and to obtain data that will allow the performance and economics of a coal biodesulfurization process to be predicted. (VC)

1991-12-01

332

Microsatellite-based genetic diversity and population structure of domestic sheep in northern Eurasia

Transposable elements (TEs) comprise a large fraction of mammalian genomes. A number of these elements are actively jumping in our genomes today. As a consequence, these insertions provide a source...Full Text Available

333

Mapping Quantitative Trait Loci Controlling Milk Production in Dairy Cattle by Exploiting Progeny Testing

BackgroundIdentification of global livestock diversity hotspots and their importance in diversity maintenance is essential for making global conservation efforts. We screened 52...Full Text Available

334

Mammalian life-span determinant p66^shcA mediates obesity-induced insulin resistance

We have exploited ``progeny testing'' to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny...Full Text Available

1995-02-01

335

Lymphocytes, neuropeptides, and genes involved in alopecia areata

Obesity and metabolic syndrome result from excess calorie intake and genetic predisposition and are mechanistically linked to type II diabetes and accelerated body aging; abnormal nutrient and insulin...Full Text Available

2010-07-27

336

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

Many lessons in autoimmunity — particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology — can be learned from the study of alopecia...Full Text Available

2007-08-01

337

Interpopulation hybridization results in widespread viability selection across the genome in Tigriopus californicus

Recently, genome-wide association studies (GWAS) have linked the human LIN28B locus to height and timing of menarche [1-Full Text Available

2010-07-01

338

Integrase-directed recovery of functional genes from genomic libraries

BackgroundGenetic interactions within hybrids influence their overall fitness. Understanding the details of these interactions can improve our understanding of speciation. One experimental...Full Text Available

339

Insecticidal properties of genetically engineered baculoviruses expressing an insect juvenile hormone esterase gene.

Large population sizes, rapid growth and 3.8 billion years of evolution firmly establish microorganisms as a major source of the planet's biological and genetic diversity. However, up to 99% of the...Full Text Available

2009-09-01

340

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Exploring the possibility of enhancing the properties of baculoviruses as biological control agents of insect pests, we tested the effect of expressing an insect gene (jhe) encoding juvenile hormone...Full Text Available

1992-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Inferring gene regulatory networks from asynchronous microarray data with AIRnet

As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc...Full Text Available

2010-02-02

342

Infant Milk Feeding Influences Adult Bone Health: A Prospective Study from Birth to 32 Years

BackgroundModern approaches to treating genetic disorders, cancers and even epidemics rely on a detailed understanding of the underlying gene signaling network. Previous work has...Full Text Available

343

Increased Ethanol Productivity in Xylose-Utilizing Saccharomyces cerevisiae via a Randomly Mutagenized Xylose Reductase?

BackgroundPeak bone mass, attained by early adulthood, is influenced by genetic and life-style factors. Early infant feeding and duration of breastfeeding in particular, associate...Full Text Available

344

In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression

Baker's yeast (Saccharomyces cerevisiae) has been genetically engineered to ferment the pentose sugar xylose present in lignocellulose biomass. One of the reactions controlling the...Full Text Available

2010-12-01

345

Improvement of Aroma in Transgenic Potato As a Consequence of Impairing Tuber Browning

Mouse models have dramatically improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic...Full Text Available

2009-10-01

346

Impaired replication dynamics at the FRA3B common fragile site

Sensory analysis studies are critical in the development of quality enhanced crops, and may be an important component in the public acceptance of genetically modified foods. It has recently been established...Full Text Available

347

Impact of genetic changes to the CRPV genome and their application to the study of pathogenesis in vivo

Chromosomal common fragile sites (CFSs) are genetically unstable regions of the genome that are induced by conditions that impair DNA replication. In this report, we show that treatment with the DNA...Full Text Available

2010-01-01

348

Immortalizing the Complexity of Cancer Metastasis Genetic Features of Lethal Metastatic Pancreatic Cancer Obtained from Rapid Autopsy

The cottontail rabbit papillomavirus (CRPV)/rabbit model has been used to study oncogenicity and immunogenicity of different antigens from the papillomavirus genome and has therefore served...Full Text Available

2007-02-20

349

Identification of genetic variation and haplotype structure of the canine ABCA4 gene for retinal disease association studies

The virtual lack of well-characterized metastatic pancreatic cancer tissues for study has limited systematic studies of the metastatic process of this deadly disease. To address this important...Full Text Available

2005-05-01

350

Identification of genes and haplotypes that predict rheumatoid arthritis using random forests

Over 200 mutations in the retina specific member of the ATP-binding cassette transporter super-family (ABCA4) have been associated with a diverse group of human retinal diseases....Full Text Available

2010-10-01

351

Identification of a Copper-Responsive Two-Component System on the Chromosome of Escherichia coli K-12

Random forest (RF) analysis of genetic data does not require specification of the mode of inheritance, and provides measures of variable importance that incorporate interaction effects. In this paper...Full Text Available

352

Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome

Using a genetic screen we have identified two chromosomal genes, cusRS (ylcA ybcZ), from Escherichia coli K-12 that encode a two-component, signal...Full Text Available

2000-10-01

353

ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine

The IFAP syndrome is a rare X-linked genetic disorder reported in nearly 40 patients. It is characterized by the triad of Ichthyosis Follicularis, Alopecia, and Photophobia from birth. Other features...Full Text Available

354

How DNA coiling enhances target localization by proteins

BackgroundAnimals carrying genetic mutations have provided powerful insights into the role of interstitial cells of Cajal (ICC) in motility. One classic model is...Full Text Available

2010-05-01

355

Highly lytic and persistent lentiviruses naturally present in sheep with progressive pneumonia are genetically distinct.

Many genetic processes depend on proteins interacting with specific sequences on DNA. Despite the large excess of nonspecific DNA in the cell, proteins can locate their targets rapidly. After initial...Full Text Available

2008-10-14

356

High genetic variability and low local diversity in a population of arbuscular mycorrhizal fungi

Ovine and caprine lentiviruses share the capacity to induce slowly progressive and inflammatory diseases of the central nervous system (leukoencephalitis or visna), lungs (progressive pneumonia or maedi),...Full Text Available

1984-11-01

357

Heritability of Lumbar Trabecular Bone Mechanical Properties in Baboons

Arbuscular mycorrhizal fungi (AMF) are ecologically important root symbionts of most terrestrial plants. Ecological studies of AMF have concentrated on differences between species; largely assuming...Full Text Available

2004-02-24

358

Hereditary Connective Tissue Diseases in Young Adult Stroke: A Comprehensive Synthesis

Genetic effects on mechanical properties have been demonstrated in rodents, but not confirmed in primates. Our aim was to quantify the proportion of variation in vertebral trabecular bone mechanical...Full Text Available

2010-03-01

359

Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein*

Though the genetic background of ischaemic and haemorrhagic stroke is often polygenetic or multifactorial, it can in some cases result from a monogenic disease, particularly in young adults. Besides...Full Text Available

360

Genome-wide detection and characterization of positive selection in human populations

Chemical genetics is an emerging approach to investigate the biology of host-pathogen interactions. We screened several inhibitors of ATP-dependent DNA motors and detected the gyrase B inhibitor coumermycin...Full Text Available

2010-12-10

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361

Genome-wide characterization of simple sequence repeats in cucumber (Cucumis sativus L.)

With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms...Full Text Available

2007-10-18

362

Genetics of the mammalian phenylalanine hydroxylase system. Studies of human liver phenylalanine hydroxylase subunit structure and of mutations in phenylketonuria.

BackgroundCucumber, Cucumis sativus L. is an important vegetable crop worldwide. Until very recently, cucumber genetic and genomic resources, especially molecular...Full Text Available

363

Genetics and molecular pathology of Stargardt-like macular degeneration

Phenylalanine hydroxylase was purified from crude extracts of human livers which show enzyme activity by usine two different methods: (a) affinity chromatography and (b) immunoprecipitation with an...Full Text Available

1979-08-01

364

Genetic heterogeneity in human T-cell leukemia/lymphoma virus type II.

Stargardt-like macular degeneration (STGD3) is an early onset, autosomal dominant macular degeneration. STGD3 is characterized by a progressive pathology, the loss of central vision, atrophy...Full Text Available

2010-05-01

365

Genetic effects of introgression genomic components from Sea Island cotton (Gossypium barbadense L.) on fiber related traits in upland cotton (G. hirsutum L.)

DNA from the peripheral blood mononuclear cells of 17 different individuals infected with human T-cell lymphoma/leukemia virus type II (HTLV-II) was successfully amplified by the polymerase chain reaction...Full Text Available

1993-03-01

366

British Library Electronic Table of Contents (United Kingdom)

The germplasm with exotic genomic components especially from Sea Island cotton (Gossypium barbadense L. Gb) is the dominant genetic resources to enhance fiber quality of upland cotton (G. hirsutum L., Gh). Due to low efficiency of phenotypic evaluation and selection on fiber quality, genetic dissection of favorable alleles using molecular markers is essential. Genetic dissection on putative Gb introgressions related to fiber traits were conducted by SSR markers with mapping populations derived from a cross between Luyuan343 (LY343), a superior fiber quality introgression line (IL) with genomic components from Gb, and an elite Upland cotton cv. Lumianyan#22 (LMY22). Among 82 polymorphic loci screened out from 4050 SSRs, 42 were identified as putative introgression alleles. A total of 29 fib...

2011-01-01

367

Genetic association between the COMT genotype and urinary levels of tea polyphenols and their metabolites among daily green tea drinkers

Genetic architecture of voluntary exercise in an advanced intercross line of mice

Available in vitro and animal studies have shown cancer protective effects of tea polyphenols. Recent study suggests a greater protective effect of green tea intake on breast cancer...Full Text Available

368

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations and effects...Full Text Available

2010-07-01

369

Genetic Variation at the Mitochondrial DNA 9-bp Repeat Locus in the Sakha of Siberia

Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations,...Full Text Available

2010-03-01

370

Genetic Susceptibility for Individual Cooperation Preferences: The Role of Monoamine Oxidase A Gene (MAOA) in the Voluntary Provision of Public Goods

... 16223, 16292, and 16295, which classify them as haplogroup W (Richards et al. 2000). The sample that was ... belonged to haplogroup B, 2 individuals belonged to haplogroup W, and 1 individual belonged to ...

371

Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

In the context of social dilemmas, previous research has shown that human cooperation is mainly based on the social norm of conditional cooperation. While in most cases individuals behave according...Full Text Available

372

Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT

It is widely accepted that specific human papillomavirus (HPV) types are the central etiologic agent of cervical carcinogenesis. However, a number of infected women do not develop invasive lesions,...Full Text Available

373

Genetic Heterogeneity in Severe Congenital Neutropenia: How Many Aberrant Pathways Can Kill a Neutrophil?

γ-Aminobutyric acid (GABA)-ergic transmission is critical for normal cortical function and is likely abnormal in a variety of neuropsychiatric disorders. We tested the in...Full Text Available

2010-07-01

374

Genetic Evidence for Inhibition of Bacterial Division Protein FtsZ by Berberine

Purpose of reviewSevere congenital neutropenia (SCN) is a primary immunodeficiency in which lack of neutrophils causes inadequate innate immune host response to bacterial...Full Text Available

2007-12-01

375

Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese

BackgroundBerberine is a plant alkaloid that is widely used as an anti-infective in traditional medicine. Escherichia coli exposed to berberine form filaments, suggesting...Full Text Available

376

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1?

The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important...Full Text Available

2011-03-01

377

Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice

Keap1 regulates Nrf2 activity in response to xenobiotic and oxidative stresses. Nrf2 is an essential regulator of cytoprotective genes. Keap1-null mice are lethal by weaning age due...Full Text Available

2010-06-01

378

Generation of Novel Bacterial Regulatory Proteins That Detect Priority Pollutant Phenols

Cigarette smoke (CS) induces recruitment of inflammatory cells in the lungs leading to the generation of reactive oxygen species (ROS), which are involved in lung inflammation and injury. Nicotinamide...Full Text Available

2008-05-01

379

Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease

The genetic systems of bacteria that have the ability to use organic pollutants as carbon and energy sources can be adapted to create bacterial biosensors for the detection of industrial pollution....Full Text Available

2000-01-01

380

Gene-Environment Interactions and Epigenetic Basis of Human Diseases

Despite the recent success of genome-wide association studies (GWASs) in identifying loci consistently associated with coronary artery disease (CAD), a large proportion of the genetic components of...Full Text Available

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

Frequent Promoter Hypermethylation of the APC and RASSF1A Tumour Suppressors in Parathyroid Tumours

Most human diseases are related in some way to the loss or gain in gene functions. Regulation of gene expression is a complex process. In addition to genetic mechanisms, epigenetic causes are...Full Text Available

2008-01-01

382

Familial occurrence of unilateral giant breasts in Nigeria: a possible new genetic entity.

BackgroundParathyroid adenomas constitute the most common entity in primary hyperparathyroidism, and although recent advances have been made regarding the underlying genetic cause...Full Text Available

383

Extracellular Administration of BCL2 Protein Reduces Apoptosis and Improves Survival in a Murine Model of Sepsis

Four cases of unilateral giant breasts from two unrelated families are described. Three of the patients were managed surgically. It is speculated from a review of available published reports that this...Full Text Available

1984-04-01

384

Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma

BackgroundSevere sepsis and septic shock are major causes of morbidity and mortality worldwide. In experimental sepsis there is prominent apoptosis of various cell types, and genetic...Full Text Available

385

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

BackgroundNon-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize....Full Text Available

386

Estimation of effective population sizes from data on genetic markers

The incidence of melanoma is increasing more than any other cancer, and knowledge of its genetic alterations is limited. To systematically analyze such alterations, we performed whole-exome...Full Text Available

2011-05-01

387

Establishing the scientific and mechanistic framework for a GIN (Genetic Improvement Network)

The effective population size (N_e) is an important parameter in ecology, evolutionary biology and conservation biology. It is, however, notoriously difficult to estimate,...Full Text Available

2005-07-29

388

Environmental Research Database

Objectives7. (b) Objectives General background Livestock production accounts for 70% of the agricultural land on the planet. Given that demand for livestock products is expected to double by 2050 it is vital that we identify less polluting ways of production, spanning both intensive and extensive systems. Northern Europe is one of the few parts of the globe where climate change is expected to be neutral or even benefit agricultural productivity. Hence it is likely to make an even more important co [continued...]DescriptionRuminant genetic improvement can play an important role in developing livestock systems that will be sustainable in the future, and produce food in an environmentally friendly manner. Also, genetic improvement of livestock is a particularly cost-effective technology, producing permanent and cumulative changes in performance. Moran et al (2007) showed the very high value of animal and plant genetics ...

2010-01-31

389

Engineering of a psychrophilic bacterium for the bioremediation of aromatic compounds

Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules

Microbial degradation of aromatic hydrocarbons has been studied with the aim of developing applications for the removal of toxic compounds. Efforts have been directed toward the genetic manipulation...Full Text Available

2010-05-01

390

Djinn Lite: a tool for customised gene transcript modelling, annotation-data enrichment and exploration

The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity. Recently,...Full Text Available

2011-07-01

391

Dissecting the Genetic Components of Adaptation of Escherichia coli to the Mouse Gut

BackgroundThere is an ever increasing rate of data made available on genetic variation, transcriptomes and proteomes. Similarly, a growing variety of bioinformatic programs are becoming...Full Text Available

392

Differential effects of the mottled yellow and pseudoagouti phenotypes on immunocompetence in Avy/a mice.

While pleiotropic adaptive mutations are thought to be central for evolution, little is known on the downstream molecular effects allowing adaptation to complex ecologically relevant environments. Here...Full Text Available

2008-01-01

393

Development of an extrachromosomal cloning vector system for use in Borrelia burgdorferi

Whereas genetic factors are known to influence both susceptibility to carcinogens and the capacity to respond to specific antigenic stimuli, little is known regarding the influence of phenotype per...Full Text Available

1984-04-01

394

Detection of genetic mutations in repetitive DNA sequences in somatic human cells after low-dose irradiation; Nachweis genetischer Veraenderungen in repetitiven DNA-Sequenzen in somatischen menschlichen Zellen nach Bestrahlung im niedrigen Dosisbereich

Molecular genetic analysis of Borrelia burgdorferi, the cause of Lyme disease, has been hampered by the absence of any means of efficient generation, identification, and complementation...Full Text Available

2000-04-25

395

Detection and Identification of Ciprofloxacin-Resistant Yersinia pestis by Denaturing High-Performance Liquid Chromatography

No abstract prepared

1998-03-01

396

Destructive effects of smoking on molecular and genetic factors of periodontal disease

Denaturing high-performance liquid chromatography (DHPLC) has been used extensively to detect genetic variation. We used this method to detect and identify Yersinia pestis KIM5 ciprofloxacin-resistant...Full Text Available

2003-07-01

397

Design of 240,000 orthogonal 25mer DNA barcode probes

Many epidemiological evidences have proven the association between smoking and periodontal disease. The causality can be further established by linking findings of traditional epidemiological studies...Full Text Available

398

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

DNA barcodes linked to genetic features greatly facilitate screening these features in pooled formats using microarray hybridization, and new tools are needed to design large sets of barcodes to allow...Full Text Available

2009-02-17

399

De Novo Induction of Genetically Engineered Brain Tumors In Mice Using Plasmid DNA

OBJECTIVEPrevious studies showed that genetic deletion or pharmacological blockade of the receptor for advanced glycation end products (RAGE) prevents the early structural changes...Full Text Available

2010-08-01

400

Cytogenetic analysis of three sea catfish species (Teleostei, Siluriformes, Ariidae) with the first report of Ag-NOR in this fish family

Spontaneous mouse models of cancer show promise to more accurately recapitulate human disease and predict clinical efficacy. Transgenic mice or viral vectors have been required to generate spontaneous...Full Text Available

2009-01-15

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401

Contrasting Population Structures of the Genes Encoding Ten Leading Vaccine-Candidate Antigens of the Human Malaria Parasite, Plasmodium falciparum

Despite their ecological and economical importance, fishes of the family Ariidae are still genetically and cytogenetically poorly studied. Among the 133 known species of ariids, only eight have been...Full Text Available

2010-04-01

402

Construction of DNA recognition sites active in Haemophilus transformation.

The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design....Full Text Available

403

Construction and Characterization of Genetically Defined aro omp Mutants of Enterotoxigenic Escherichia coli and Preliminary Studies of Safety and Immunogenicity in Humans

Competent Haemophilus cells recognize and preferentially take up Haemophilus DNA during genetic transformation. This preferential uptake is correlated with the presence on incoming DNA of an 11-base-pair...Full Text Available

1982-04-01

404

Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in travelers to countries where the disease is endemic and causes a major disease burden in the indigenous population,...Full Text Available

2001-08-01

405

Complex Integration of Matrix, Oxidative Stress, and Apoptosis in Genetic Emphysema

Clinical applications of genetic therapies, including delivery of short, interfering RNAs (siRNAs) for RNA interference (RNAi), are limited due to the difficulty of delivering nucleic acids...Full Text Available

2010-09-01

406

Completely phased genome sequencing through chromosome sorting

Alveolar enlargement, which is characteristic of bronchopulmonary dysplasia, congenital matrix disorders, and cigarette smoke-induced emphysema, is thought to result from enhanced inflammation and ensuing...Full Text Available

2009-07-01

407

Comparative mapping of Andropogoneae: Saccharum L. (sugarcane) and its relation to sorghum and?maize

The two haploid genome sequences that a person inherits from the two parents represent the most fundamentally useful type of genetic information for the study of heritable diseases and the development...Full Text Available

2011-01-04

408

Common mitochondrial polymorphisms as risk factor for endometrial cancer

Comparative genetic maps of Papuan Saccharum officinarum L. (2n = 80) and S. robustum (2n = 80) were constructed by using single-dose...Full Text Available

1997-12-23

409

Common Genetic Variants Associate with Serum Phosphorus Concentration

Endometrial carcinoma is the most commonly diagnosed gynaecological cancer in developed countries. Although the molecular genetics of this disease has been in the focus of many research laboratories...Full Text Available

410

Co-localization of Sorting Nexin 2 and Androgen Receptor in the Song System of Juvenile Zebra Finches

Phosphorus is an essential mineral that maintains cellular energy and mineralizes the skeleton. Because complex actions of ion transporters and regulatory hormones regulate serum phosphorus concentrations,...Full Text Available

2010-07-01

411

Climate Change, Genetics or Human Choice: Why Were the Shells of Mankind's Earliest Ornament Larger in the Pleistocene Than in the Holocene?

Mechanisms regulating sexual differentiation of the zebra finch song system appear to include both genetic and hormonal factors. Sorting Nexin 2 (SNX2), which is involved in trafficking proteins...Full Text Available

2010-07-09

412

Chemical complementation: A reaction-independent genetic assay for enzyme catalysis

BackgroundThe southern African tick shell, Nassarius kraussianus (Dunker, 1846), has been identified as being the earliest known ornamental object used by human...Full Text Available

413

Calcium, Vitamin D, VDR Genotypes, and Epigenetic and Genetic Changes in Rectal Tumors

A high-throughput assay for enzyme activity has been developed that is reaction independent. In this assay, a small-molecule yeast three-hybrid system is used to link enzyme catalysis to transcription...Full Text Available

2002-12-24

414

Behavioral genomics of honeybee foraging and nest defense

Calcium, vitamin D, exposure to sunshine, and vitamin D receptor (VDR) genotypes have been associated rectal cancer. We used data from 750 rectal tumors and 1,205 population-based...Full Text Available

2010-05-01

415

Association of COMT Val^108/158Met Genotype and Cigarette Smoking in Pregnant Women

The honeybee has been the most important insect species for study of social behavior. The recently released draft genomic sequence for the bee will accelerate honeybee behavioral genetics. Although...Full Text Available

2007-04-01

416

Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100.

Introduction:Smoking behaviors, including heaviness of smoking and smoking cessation, are known to be under a degree of genetic influence. The enzyme catechol O-methyltransferase...Full Text Available

2011-02-01

417

Assessment of the bone quality of black male athletes using calcaneal ultrasound: a cross-sectional study

Familial defective apolipoprotein (apo) B-100 is a genetic disease that leads to hypercholesterolemia and to an increased serum concentration of low density lipoproteins that bind defectively to the...Full Text Available

1989-01-01

418

Antidepressant-Like Effects of ?-Opioid Receptor Antagonists in Wistar Kyoto Rats

BackgroundLifestyle, genetics and environmental factors are established determinants of bone density. We aimed to describe the bone characteristics of competitive top-ranked Nigerian...Full Text Available

419

Anticipation in familial lattice corneal dystrophy type I with R124C mutation in the TGFBI (BIGH3) gene

The Wistar Kyoto (WKY) rat strain is a putative genetic model of comorbid depression and anxiety. Previous research showing increased κ-opioid receptor (KOR)...Full Text Available

2010-02-01

420

Angiotensin II Promotes Development of the Renal Microcirculation through AT₁ Receptors

PurposeTo report the clinical, ophthalmic, and genetic characteristics for lattice corneal dystrophy type I (LCDI) in a Chilean family.MethodsSix...Full Text Available

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421

Analysis of non-TIR NBS-LRR resistance gene analogs in Musa acuminata Colla: Isolation, RFLP marker development, and physical mapping

Pharmacologic or genetic deletion of components of the renin-angiotensin system leads to postnatal kidney injury, but the roles of these components in kidney development are unknown. To test the hypothesis...Full Text Available

2010-03-01

422

Analysis of genomic differences among Clostridium botulinum type A1 strains

BackgroundMany commercial banana varieties lack sources of resistance to pests and diseases, as a consequence of sterility and narrow genetic background. Fertile wild relatives,...Full Text Available

423

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer

BackgroundType A1 Clostridium botulinum strains are a group of Gram-positive, spore-forming anaerobic bacteria that produce a genetically, biochemically, and biophysically...Full Text Available

424

An excess of rare genetic variation in ABCE1 among Yorubans and African-American individuals with HIV-1

BackgroundGenomics has substantially changed our approach to cancer research. Gene expression profiling, for example, has been utilized to delineate subtypes of cancer, and facilitated...Full Text Available

425

An Immune Basis for Malaria Protection by the Sickle Cell Trait

Signatures of natural selection occur throughout the human genome and can be detected at the sequence level. We have re-sequenced ABCE1, a host candidate gene essential for...Full Text Available

2009-12-01

426

Air pollution induces heritable DNA mutations

BackgroundMalaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism...Full Text Available

2005-05-01

427

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

Hundreds of thousands of people worldwide live or work in close proximity to steel mills. Integrated steel production generates chemical pollution containing compounds that can induce genetic damage...Full Text Available

2002-12-10

428

Activation of cycasin to a mutagen for Saccharomyces cerevisiae by rat intestinal flora.

A remarkable discovery of recent years is that, despite the complexity of ageing, simple genetic interventions can increase lifespan and improve health during ageing in laboratory animals. The pathways...Full Text Available

2011-05-01

429

A study of the genetics of dieldrin-resistance in the housefly (Musca domestica L.)*

Genetic test systems involving microorganisms and liver enzyme preparations may be insufficient to detect compounds that require breakdown by enzymes provided by the microbial flora of the intestinal...Full Text Available

1983-02-01

430

A multi-marker model for detecting chromosomal segments displaying QTL activity

Reciprocal mass crosses and back-crosses were performed between two homogeneous strains of the housefly (Musca domestica L.), representing the extremes in susceptibility and resistance...Full Text Available

1963-01-01

431

A homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, ? cell hyperplasia, and islet cell tumor

A statistical method is presented for detecting quantitative trait loci (QTLs), based on the linear model. Unlike methods able to detect a few well separated QTLs and to estimate their effects and positions, this method considers the genome as a whole and enables the detection of chromosomal segments involved in the differences between two homozygous lines, and their backcross, doubled haploid, or F[sub 2] progenies, for a quantitative trait. Genetic markers must be codominant, but missing markers are accepted, provided they are missing independently from the experiment. Asymptotic properties, which are of practical use, are developed. This method does not rely on strong genetic hypotheses, and thus does not permit any precise genetic analysis of the trait under study, but it does assess which regions of the genome are involved, whatever the complexity of the genetic determinism (number, effects and ...

1993-08-01

432

A haplotype map of the human genome

ObjectiveThe goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic α cell hyperplasia...Full Text Available

2009-11-01

433

A combination of transposable elements and magnetic cell sorting provides a very efficient transgenesis system for chicken primary erythroid progenitors

Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million...Full Text Available

2005-10-27

434

A Turquoise Mutant Genetically Separates Expression of Genes Encoding Phycoerythrin and Its Associated Linker Peptides

BackgroundStable transgenesis is an undeniable key to understanding any genetic system. Retrovirus-based insertional strategies, which feature several technical challenges when they...Full Text Available

435

A Suppression Subtractive Hybridization Approach Reveals Niche-Specific Genes That May Be Involved in Predator Avoidance in Marine Synechococcus Isolates

During complementary chromatic adaptation (CCA), cyanobacterial light harvesting structures called phycobilisomes are restructured in response to ambient light quality shifts. Transcription of genes...Full Text Available

2002-02-01

436

A Practical Approach to Genetic Inducible Fate Mapping: A Visual Guide to Mark and Track Cells In Vivo

Picocyanobacteria of the genus Synechococcus are important contributors to marine primary production and are ubiquitous in the world's oceans. This genus is genetically diverse, and...Full Text Available

2006-04-01

437

A DNA transposon-based approach to validate oncogenic mutations in the mouse

Fate maps are generated by marking and tracking cells in vivo to determine how progenitors contribute to specific structures and cell types in developing and adult tissue. An advance in this...Full Text Available

438

29 CFR 2590.702-1 - Additional requirements prohibiting discrimination based on genetic information.

Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available

2008-12-16

439

Stochastic Optimization Approaches for Solving Sudoku

...treated for leukemia. B' s physician, who is employed by the HMO, is considering a treatment plan that includes six-mercaptopurine, a drug for treating leukemia in most children. However, the drug could be fatal if taken by a small percentage of...

2010-07-01

440

CERN Document Server

In this paper the Sudoku problem is solved using stochastic search techniques and these are: Cultural Genetic Algorithm (CGA), Repulsive Particle Swarm Optimization (RPSO), Quantum Simulated Annealing (QSA) and the Hybrid method that combines Genetic Algorithm with Simulated Annealing (HGASA). The results obtained show that the CGA, QSA and HGASA are able to solve the Sudoku puzzle with CGA finding a solution in 28 seconds, while QSA finding a solution in 65 seconds and HGASA in 1.447 seconds. This is mainly because HGASA combines the parallel searching of GA with the flexibility of SA. The RPSO was found to be unable to solve the puzzle.

2008-01-01

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441

Optimal Parameter Selection of Power System Stabilizer using Genetic Algorithm

Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent

In this paper, it is suggested that the selection method of optimal parameter of power system stabilizer (PSS) with robustness in low frequency oscillation for power system using real variable elitism genetic algorithm (RVEGA). The optimal parameters were selected in the case of power system stabilizer with one lead compensator, and two lead compensator. Also, the frequency responses characteristics of PSS, the system eigenvalues criterion and the dynamic characteristics were considered in the normal load and the heavy load, which proved usefulness of RVEGA compare with Yu's compensator design theory. (author). 20 refs., 15 figs., 8 tabs.

1999-06-01

442

Estimated values of the genetic and somatic radiation exposure of the Bulgarian population in 1976

Gaussian-process models are developed to detect genetic linkage using complete high-resolution maps of identity by descent between affected relative pairs. Approximations are given for the significance level and power of the likelihood-ratio test of no linkage and for likelihood-ratio confidence regions for trait loci. The sample sizes required to detect linkage by using different classes of affected relative pairs are compared, and the problem of combining data from different classes of relatives is discussed. 23 refs., 2 figs.

1993-07-01

443

Characterization of eight microsatellite markers in the white sea bream, Diplodus sargus (Teleostei, Sparidae)

The genetically and leukemia-significant doses (GSD and LSD) were calculated from the average gonad and bone marrow doses caused by the most frequently applied radiopharmaceuticals in Bulgaria in 1976. Because of the lack of information about the age groups of the patients examined assumptions have been made which led to estimated values of 0.97 mrad for GSD and 2.0 mrad for LSD which must be considered as the upper limit of the real GSD and LSD. The influence of the different radiopharmaceuticals on the average radiation exposure of the population is discussed. (author).

1976-01-01

444

British Library Electronic Table of Contents (United Kingdom)

Abstract The white sea bream, Diplodus sargus (Teleostei, Sparidae), is a species with a high commercial importance in Mediterranean aquaculture. There is currently little information available about the genetic characteristics of cultured populations. In this survey, we have developed eight polymorphic microsatellites for the white sea bream using an enriched genome library protocol. All of them were polymorphic in the 67 individuals tested, 32 of which were wild specimens, and 35 were individuals from a captive F1 broodstock. These markers can potentially be useful tools for use in population genetic studies.

2008-01-01

445

An improved colony PCR procedure for genetic screening of Chlorella and related microalgae.

Algorithm for assessment of mean annual gonad dose and genetically significant dose from the data of personal dosimetry

A colony PCR technique was applied for both genomic and chloroplast DNA in the green microalgae Chlorella. Of five different lysis buffers, Chelex-100 was superior for DNA extraction, PCR and DNA storage. It also was insensitive to variations in cell density. The conditions established for an improved PCR formulation are applicable for screening of genetically-engineered transformants as well as bioprospecting of natural microalgal isolates. Besides multiple Chlorella species, we also demonstrate the efficacy of Chelex-100 for colony PCR with a number of other microalgal strains, including Chlamydomonas reinhardtii, Dunaliella salina, Nannochloropsis sp., Coccomyxa sp., and Thalassiosira pseudonana. PMID:21431847

2011-03-24

446

Genetic and physical location of the gene for Stargardt`s disease and further evidence for genetic homogeneity

During one year more than 40,000 items of information on radiation exposure of personnel involved in the handling of radiation sources and more than 5,000,000 items on irradiation of other people are collected in the authors' laboratory. Considerable progress in assessment of mean annual gonad dose of genetically sifnificant dose was attained by means of an algorithm for a personal computer. This simple and inexpensive system has led to a higher accuracy in the application of protective measures. (author).

1985-10-22

447

skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release.

Stargardt`s disease is inherited as an autosomal recessive condition characterized by a juvenile macular dystrophy. Genetic linkage analysis recently assigned the disease locus to chromosome 1p21-p13 with the best estimate for location of the gene near the locus D1S435. We performed linkage analysis in 34 North American families and 2 inbred families from the Kingdom of Saudi Arabia with 12 highly polymorphic markers on chromosome 1p flanking D1S435 between D1S207 and D1S223 and report significant linkage for all 12 markers with no evidence for genetic heterogeneity. Two-point linkage analysis demonstrated the Stargardt`s disease locus and D1S435 are linked with a maximum lod score of 17.17 at a recombination fraction of 1%. The markers UT851, D1S188, D1S424, UT2069, and D1S236 also demonstrated recombination fractions of 1% or less with two-point lod scores of 15.86, 21.93, 16.41, 20.36, and 17.37, respectively. To characterize this region ...

1994-09-01

448

p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury

The phosphatidylinositol pathway is implicated in the regulation of numerous cellular functions and responses to extracellular signals. An important branching point in the pathway is the phosphorylation...Full Text Available

1998-12-01

449

UV renormalons in QCD and their phenomenological implications

The side effects of cancer therapy on normal tissues limit the success of therapy. Generation of reactive oxygen species (ROS) has been implicated for numerous chemotherapeutic agents including doxorubicin...Full Text Available

450

Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens

I report on some recent work done in collaboration with E. de Rafael on the connection between ultraviolet renormalons in QCD and Nambu-Jona-Lasinio-like Lagrangians as its effective description at low energies. (orig.)

1998-05-01

451

The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe Disease

Recent research has implicated the nucleus accumbens (NAc) in consolidating recently acquired goal-directed appetitive memories, including spatial learning and other instrumental processes. However,...Full Text Available

2005-04-26

452

The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae

Krabbe disease (KD) is an inherited neurological disorder caused by the deficiency of galactocerebrosidase activity resulting in accumulation of psychosine, which leads to energy depletion,...Full Text Available

2008-06-01

453

The Formation of Anthocyanic Vacuolar Inclusions in Arabidopsis thaliana and Implications for the Sequestration of Anthocyanin Pigments

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover,...Full Text Available

454

The 4th Annual International Conference on Hormesis: Implications for Toxicology, Medicine and Risk Assessment. The annual Meeting of the International Hormesis Society. Abstract Book. June 6-8, 2005, University of Massachusetts, Amherst, MA. 26 pages.

Anthocyanins are flavonoid pigments that accumulate in the large central vacuole of most plants. Inside the vacuole, anthocyanins can be found uniformly distributed or as part of sub-vacuolar pigment...Full Text Available

2010-01-01

455

Stem Cell Research Policies around the World

No abstract prepared.

2007-01-01

456

Star-formation triggers and chemical evolution

The proliferation of stem cell research, conflated with its ethical and moral implications, has led governments to attempt regulation of both the science and funding of stem cells. Due to a diversity...Full Text Available

2009-09-01

457

Selection of Inhibitor-Resistant Viral Potassium Channels Identifies a Selectivity Filter Site that Affects Barium and Amantadine Block

Comparative studies of flocculent and grand-design spirals suggest that density waves are not the predominant trigger of star formation in most galaxies. Implications for chemical evolution are profound. It may be possible to ignore the details of the spiral-wave phenomenon in research aimed at unifying the chemical properties of spiral disks. 16 references.

1986-10-01

458

Safety Implications of High-Field MRI: Actuation of Endogenous Magnetic Iron Oxides in the Human Body

BackgroundUnderstanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function...Full Text Available

459

Role of nitroso radicals as drug targets in circulatory shock

BackgroundMagnetic Resonance Imaging scanners have become ubiquitous in hospitals and high-field systems (greater than 3 Tesla) are becoming increasingly common. In light of recent...Full Text Available

460

Reversal of Depressed Behaviors by p11 Gene Therapy in the Nucleus Accumbens

A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially, superoxide and hydroxyl radical) and high-energy oxidants [such as peroxynitrite (OONO⁻)]...Full Text Available

2009-06-01

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461

Regulatory T Cells in Many Flavors Control Asthma

The etiology of major depression remains unknown, but dysfunction of serotonergic signaling has long been implicated in the pathophysiology of this disorder. p11 is an S100 family member recently...Full Text Available

2010-10-20

462

RasGrf1 deficiency delays aging in mice

That regulatory T cells (Tregs) have a crucial role in controlling allergic diseases such as asthma is now undisputed. The cytokines most commonly implicated in Treg-mediated suppression of...Full Text Available

2010-05-01

463

Primary and secondary structure of the pore-forming peptide of pathogenic Entamoeba histolytica.

RasGRF1 is a Ras-guanine nucleotide exchange factor implicated in a variety of physiological processes including learning and memory and glucose homeostasis. To determine the role of RASGRF1 in aging,...Full Text Available

464

Preterm low birthweight and the role of oral bacteria

A pore-forming peptide is implicated in the potent cytolytic activity of pathogenic Entamoeba histolytica. Using NH2-terminal sequence information of this peptide, the corresponding cDNA was isolated....Full Text Available

1992-10-01

465

Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice

Preterm and low birthweight (PTLBW) continues to be a major cause of mortality and morbidity across the world. In recent years, maternal periodontal disease has been implicated as a risk factor for...Full Text Available

466

Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging

OBJECTIVENicotinamide adenine dinucleotides (NAD⁺ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD⁺-to-NADH ratio is implicated...Full Text Available

2009-04-01

467

Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling

The nucleocapsid protein (NC) of retroviruses plays a major role in genomic RNA packaging, and some evidence has implicated the matrix protein (MA) of certain retroviruses in viral RNA binding. To further...Full Text Available

1998-03-01

468

Misdiagnosed HIV infection in pregnant women: implications for clinical care.

Neutral endopeptidase 24.11 (NEP, CD10) is a cell-surface enzyme expressed by prostatic epithelial cells that cleaves and inactivates neuropeptides implicated in the growth of androgen-independent prostate...Full Text Available

2000-12-01

469

Mammalian models of extended healthy lifespan

Out of nearly 900 women in a research study of human immunodeficiency virus infection in pregnancy, 8 were subsequently found not to be infected. Misdiagnoses could have resulted from (a) laboratory...Full Text Available

1994-09-01

470

Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy

Over the last two centuries, there has been a significant increase in average lifespan expectancy in the developed world. One unambiguous clinical implication of getting older is the risk of experiencing...Full Text Available

2011-01-12

471

Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease

The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with...Full Text Available

2008-11-01

472

Inhibition of HIV-1 Infection in Ex Vivo Cervical Tissue Model of Human Vagina by Palmitic Acid; Implications for a Microbicide Development

Stargardt disease (STGD) is the major form of inherited juvenile macular degeneration. Pyridinium bis-retinoid A2E is a major component of lipofuscin which accumulates in retinal pigment epithelium...Full Text Available

2010-10-12

473

Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in relatives of patients with autoimmune thyroid disease

BackgroundApproximately 80% of all new HIV-1 infections are acquired through sexual contact. Currently, there is no clinically approved microbicide, indicating a clear and...Full Text Available

474

Implications of abrupt climate change.

Infections have been implicated in the pathogenesis of a number of autoimmune diseases, and Yersinia enterocolitica (YE) might play a role in the development of autoimmune thyroid disease...Full Text Available

2003-05-01

475

Household Water Disinfection in Hurricane-Affected Communities of Louisiana: Implications for Disaster Preparedness for the General Public

Records of past climates contained in ice cores, ocean sediments, and other archives show that large, abrupt, widespread climate changes have occurred repeatedly in the past. These changes were especially...Full Text Available

2004-01-01

476

HPV16 E2 could act as down-regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation

Objectives. Thousands of Louisiana residents were asked to boil water because of widespread disruptions in electricity and natural gas services after Hurricane Rita. We sought to assess...Full Text Available

2007-04-01

477

Glucocorticoids exacerbate hypoxia induced expression of the pro-apoptotic gene Bnip3 in the developing cortex

BackgroundHuman Papillomavirus (HPV) E2 plays several important roles in the viral cycle, including the transcriptional regulation of the oncogenes E6 and E7, the regulation of the...Full Text Available

478

Gene expression profile of rat left ventricles reveals persisting changes following chronic mild exercise protocol: implications for cardioprotection

Neonatal administration of the synthetic glucocorticoid, dexamethasone (DEX) retards brain growth, alters adult behaviors and induces cell death in the rat brain, thereby implicating glucocorticoids...Full Text Available

2007-01-19

479

Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors

BackgroundEpidemiological studies showed that physical exercise, specifically moderate lifelong training, is protective against cardiovascular morbidity and mortality. Most experimental...Full Text Available

480

Experimental Approaches to the Study of A2E, a Bisretinoid Lipofuscin Chromophore of Retinal Pigment Epithelium

BackgroundLeukotrienes (LTs) belong to the large family of lipid mediators implicated in various inflammatory conditions such as asthma and rheumatoid arthritis. Four distinct types...Full Text Available

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481

Effects of hypocretin (orexin) neuronal loss on sleep and extracellular adenosine levels in the basal forebrain

Bisretinoid lipofuscin compounds that accumulate in retinal pigment epithelial (RPE) cells are implicated in the pathogenesis of some forms of macular degeneration. In the development of approaches...Full Text Available

2010-01-01

482

Effective In Vitro Clearance of Porphyromonas gingivalis by Fc? Receptor I (CD89) on Gingival Crevicular Neutrophils

Neurons containing the neuropeptide hypocretin (orexin) are localized only in the lateral hypothalamus from where they innervate multiple regions implicated in arousal, including the basal forebrain....Full Text Available

2008-09-01

483

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks

Porphyromonas gingivalis has been implicated as a causative pathogen in periodontitis. Immunotherapeutic approaches have recently been suggested to aid in the clearance of P....Full Text Available

2001-05-01

484

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

The sirtuin Sirt6 is a NAD-dependent histone deacetylase that is implicated in gene regulation and lifespan control. Sirt6 can interact with the stress-responsive transcription factor NF-κB...Full Text Available

2011-06-01

485

Cystic fibrosis. 4. Abnormalities of airway epithelial function and the implications of the discovery of the cystic fibrosis gene.

Circadian clock is implicated in the regulation of aging. The transcription factor CLOCK, a core component of the circadian system, operates in complex with another circadian clock protein BMAL1. Recently...Full Text Available

486

Critical nucleus size for disease-related polyglutamine aggregation is repeat length dependent

Details of ion transporting abnormalities in cystic fibrosis airway epithelium are now known. The central hypothesis, that excessive drying of the airway surfaces is a primary event that leads to all...Full Text Available

1991-02-01

487

Comparison of the Maturation of the Adrenergic and Serotonergic Neurotransmitter Systems in the Brain: Implications for Differential Drug Effects on Juveniles and Adults

Since polyglutamine (polyQ) aggregate formation has been implicated as playing an important role in expanded CAG repeat diseases, it is important to understand the biophysics underlying the...Full Text Available

2011-03-01

488

Clinical Implications of Immunohistochemically Demonstrated Lymph Node Micrometastasis in Resectable Pancreatic Cancer

Our understanding of the development of neurotransmitter systems in the central nervous system has increased greatly over the past three decades and it has become apparent that drug effects...Full Text Available

2007-04-15

489

Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated

The purpose of this study was to determine the clinical significance of nodal micrometastasis detected by immunohistochemistry in patients that had undergone curative surgery for pancreatic cancer....Full Text Available

2011-07-01

490

Chest pain and angiographically normal coronary arteries. Implications for treatment.

BackgroundMultiple sclerosis (MS) is the endpoint of a complex and still poorly understood process which results in inflammation, demyelination and axonal and neuronal degeneration....Full Text Available

491

Approximately 20% to 30% of patients who undergo coronary arteriography for the evaluation of chest pain are found to have normal coronary arteries. These patients have a survival rate comparable to...Full Text Available

1993-01-01

492

Big bang nucleosynthesis

Autophosphorylation Within the Atg1 Activation Loop Is Required for Both Kinase Activity and the Induction of Autophagy in Saccharomyces cerevisiae

The concordance of standard big bang nucleosynthesis theory and the related observations of the light element isotopes (including some new higher {sup 4}He abundances) will be reviewed. Implications of BBN on chemical evolution, dark matter and constraints on particle properties will be discussed.

1999-01-01

493

Aspirin Treatment of Mice Infected with Trypanosoma cruzi and Implications for the Pathogenesis of Chagas Disease

Autophagy is an evolutionarily conserved degradative pathway that has been implicated in a number of physiological events important for human health. This process was originally identified as a response...Full Text Available

2010-07-01

494

Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction

Chagas disease, caused by infection with Trypanosoma cruzi, is an important cause of cardiovascular disease. It is increasingly clear that parasite-derived prostaglandins potently modulate...Full Text Available

495

Advances in the detection of neutrinoless double beta decay

BackgroundFormation of site specific genomic double strand breaks (DSBs), induced by the expression of a pair of engineered zinc-finger nucleases (ZFNs), dramatically increases the...Full Text Available

496

British Library Electronic Table of Contents (United Kingdom)

This paper introduces briefly neutrinoless Double Beta Decay and discusses its implications for neutrino physics. After a presentation of general experimental concepts, such as the various proposed methodological approaches and the sensitivity, the current experimental situation is concisely reviewed.

2011-01-01

497

A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention

A new analysis for membrane noise. The integral spectrum.

BackgroundCentrosome aberrations can cause genomic instability and correlate with malignant progression in common human malignancies such as breast and prostate cancer. Deregulation...Full Text Available

498

A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans

A new method of random data analysis has been developed with special implications for membrane noise. The integral spectrometer uses overlapping broad-band filters of simple design, whose bandwidth...Full Text Available

1976-07-01

499