california mice peromyscus: Topics by WorldWideScience.org

Global Warming and California's Public Health

... being reported (Kisseberth et al., 1984; Ma, 1989; Shore and Douben, 1994). Small mammals are useful indicator species because they have relatively small home ranges allowing a direct tie to the source of ...

2

Global Warming and California's Electricity Supply

This fact sheet summarizes the potential impact of climate change as it relates to public health in California....

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Energy and Water Conservation

This fact sheet summarizes the potential impact of climate change as it relates to California's electricity supply. ...

4

NIH News -- HHS Awards More Than $56 Million to Eliminate Health...

Jet Propulsion Laboratory. California Institute of Technology. Pasadena, California. Energy and Water Conservation. Steve Rigdon. Facilities Energy Manager ...

5

The numerical response of breeding Northern Saw-whet Owls Aegolius acadicus suggests nomadism

Fairbanks Fairbanks Alaska University of Arizona College of Public Health Tucson Arizona University of California Los Angeles California RAND Corporation Santa Monica California...

2006-01-11

6

British Library Electronic Table of Contents (United Kingdom)

We used a 13-year time series of abundance estimates of breeding Northern Saw-whet Owls (Aegolius acadicus), and of small mammals from central Ontario, Canada, to assess the numerical response of the owls to small-mammal prey species. We found that the finite rate of increase of breeding owls was directly related to estimates of red-backed vole (Myodes gapperi) abundance. Thus, it appeared that the owls were nomadic, and made decisions about where to breed based on vole supply. The owls showed a much weaker response to deer mouse (Peromyscus maniculatus) abundance. Across all years, 55% of variation in owl rate of increase could be uniquely attributed to vole abundance, whereas only 3% could be attributed to mouse abundance. Consistent with the model of nomadism, there was only a weak rela...

2010-01-01

7

Timber Harvest Plans

Submarine geology of Santa Monica Bay, California / by Richard D. Terry , Stuart A. Keesling and Elazar Uchupi.

Timber harvesting histories generated by the California Department of Forestry and Fire Protection's Coast-Cascade GIS ... ...

8

Radiation and fetal brain development

Language: English ...

9

Drifting oscillating two-stream instability

(4 Sep 1986). United Kingdom Zamenhof, Stephen . California Univ., Los

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Effect of Spices on hepatic microsomal enzyme function in mice

United States Johnston, GL Department of Physics and Astronomy, California

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Assessment of Embryotoxicity of 2-Bromopropane in ICR Mice

Full Text Available

1984-06-01

12

Antioxidant activity and anti-tumor immunity by Propolis in mice

Full Text Available

2003-09-01

13

Penicillinase-producing Neisseria gonorrhoeae in California. Report of a major outbreak and control recommendations.

Full Text Available

2005-06-01

14

A duplex real-time RT-PCR assay for the detection of California serogroup and Cache Valley viruses

A major outbreak of penicillinase-producing Neisseria gonorrhoeae occurred in California beginning in late 1986. After a state public health emergency was declared in April 1987, a statewide, cooperative...Full Text Available

1989-09-01

15

Tidal effects as criteria for membership in small groups of galaxies: Application to VV 166

A duplex TaqMan real-time RT-PCR assay was developed for the detection of California (CAL) serogroup viruses and Cache Valley virus (CVV), for use in human surveillance. The targets selected...Full Text Available

2009-10-01

16

The Influence of Timber Harvest on the Distribution of Exotic Riparian

United States Kormendy, J. Sargent, WLW Hale Observatories, California

17

STRUCTURE OF LIQUID NITROGEN,

... the Redwood Creek basin in north coastal California, timber harvest and associated streamside landsliding altered the composition ... ...

18

Liquid nitrogen dewar for protein crystal growth

... Accession Number : AD0618975. Title : STRUCTURE OF LIQUID NITROGEN,. Corporate Author : CALIFORNIA INST OF TECH PASADENA. ...

1962-03-27

19

Application of the shunted junction model to point-contact Josephson junctions

Gaseous Nitrogen Dewar apparatus developed by Dr. Alex McPherson of the University of California,

2001-01-01

20

50 CFR 17.96 - Critical habitat-plants.

1974. United States Taur, Y. Univ. of California, Berkeley Richards, PL Auracher,

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Female Scent Signals Enhance the Resistance of Male Mice to Influenza

...ER14AU08.000 (6) Unit 2: North Baldwin Meadow, San Bernardino County, California...and ARUR 12. Gold Mountain and North Baldwin Lake, San Bernardino County, California...ER26DE07.007(13) Unit ARUR 15. South Baldwin Ridge/Erwin Lake, San Bernardino...

2010-10-01

22

Consistency in potency assay of tetanus toxoid in mice

BackgroundThe scent from receptive female mice functions as a signal, which stimulates male mice to search for potential mating partners. This searching behavior is coupled with...Full Text Available

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Characterization of antibodies mediating protection and cure of Trypanosoma musculi infection in mice.

The use of mice for the assay of tetanus toxoids would offer considerable advantages over the use of guinea-pigs, but mice cannot readily be immunized with the fluid tetanus toxoid at present designated...Full Text Available

1959-01-01

24

Anti-erythrocyte autoantibody production in mice associated with the injection of rat erythrocytes.

Plasma samples were collected from mice infected with Trypanosoma musculi at different times postinfection and administered to naive recipient mice either before or during T. musculi infection. The...Full Text Available

1985-06-01

25

California's Proposition 15: the what and why of its defeat

Mice injected with rat erythrocytes developed anti-erythrocyte autoantibodies which reached a plateau at 4-12 weeks, then gradually declined until at about 24 weeks the majority of mice were negative....Full Text Available

1980-04-01

26

Bi-directional causality in California's electricity and natural-gas markets

This analysis of the June 8, 1976 California Nuclear Initiative was prepared by the Pacific Gas and Electric Co. The defeat of Proposition 15 in the California election was successful for several reasons. A record 70 percent of the voters in California went to the polls and 97 percent of those voted on the nuclear issue with the results showing defeat by two-to-one. Apparently, the voters perceived the Nuclear Initiative as being too drastic. The campaign for defeat of the initiative stressed the consequences of closing down existing plants and closing off the nuclear option in California, namely: higher costs, job losses, and less-desirable alternatives. The campaign waged for the Initiative seems to have suffered from weak management and lack of consistent messages.

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Bi-directional causality in California's electricity and natural-gas markets

The Granger instantaneous-causality test is applied to explore the potential causal relationships between wholesale electricity and natural-gas prices in California. The test shows these relationships to be bi-directional, and reveals California's electricity and natural-gas markets to be as inextricably intertwined as casual observation and theoretical considerations would suggest they ought to be. This meshing of markets exacerbated the effects of California's natural-gas crisis on the contemporaneous electricity crisis, while concurrently the electricity crisis may have contributed to the dysfunction in the national-gas market and helped to precipitate the natural-gas crisis. The finding supports an integrated approach, as opposed to a piecemeal approach, for formulating energy policy recommendations, not just in California but in the world at large. (author)

2006-10-01

28

Comparison of wave energy flux for northern, central, and southern coast of California based on long-term statistical wave data

The Granger instantaneous-causality test is applied to explore the potential causal relationships between wholesale electricity and natural-gas prices in California. The test shows these relationships to be bi-directional, and reveals California's electricity and natural-gas markets to be as inextricably intertwined as casual observation and theoretical considerations would suggest they ought to be. This meshing of markets exacerbated the effects of California's natural-gas crisis on the contemporaneous electricity crisis, while concurrently the electricity crisis may have contributed to the dysfunction in the national-gas market and helped to precipitate the natural-gas crisis. The finding supports an integrated approach, as opposed to a piecemeal approach, for formulating energy policy recommendations, not just in California but in the world at large.

2006-10-01

29

Mice as a Mammalian Model for Research on the Genetics of Aging

California's pacific coast stretches roughly over 11.5 latitudinal degrees, extending from about 32.5{sup o}N to 44{sup o}N. There is nearly 900nm of California coastline offering superior opportunity for wave energy use. The longitudinal position of the coast shifts eastward at two distinct locations: Punta Gorda just south of Cape Mendecino in the north and Point Conception in the south. The change in longitudinal orientation in southern California also coincides with significant change in California's bathymetry. The tilts in the longitudinal coastal lines at the two points also define California wave zones into three areas: the short coastal line north of Punta Gorda, the long north and middle line between the two points, and the short line of the heavily populated southern coast. The northern and central zones are characterized by high waves of relatively low ...

2006-09-15

30

Signet ring cell carcinomas of gastric mucosa in hypocatalasemic mice treated with X-ray or chemicals

Mice are an ideal mammalian model for studying the genetics of aging: considerable resources are available, the generation time is short, and the environment can be easily controlled, an important...Full Text Available

2011-02-08

31

In-vivo study on the harmful effect of the extremely low frequency unipolar pulsating magnetic field in mice.

Short communication.

32

Effect of Ondansetron Alone and Combination of Naltrexone and Ondansetron on Alcohol Intake in C57BL/6 Mice

Full Text Available

1997-04-01

33

Effect of Bisphenol A Administration on Reproductive Toxicant of Dam and Sex Ratio of Pups in Pregnant Mice

Full Text Available

2007-11-01

34

Distribution of Calretinin-immunoreactive Unipolar Brush Cells in Ataxic Mutant Pogo Mice Cerebellum

Full Text Available

2005-06-01

35

Ameliorating Effect of Capsaicin on Alterations in Lipid Metabolism during Mice Lung Carcinoma

Full Text Available

2005-08-01

36

Alterations in dopamine and glutamate neurotransmission in tetrahydrobiopterin deficient spr-/- mice: relevance to schizophrenia

Full Text Available

2009-02-01

37

2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Like Immune Alteration in Mice

Full Text Available

2010-09-01

38

Weeds of California and Other Western States

Full Text Available

2006-12-01

39

Summary Report of the Summer Conference DARPA ...

... Appendix (including Asclepias fruticosa, Chrysanthemum balsamita, Silene pseudatocion, Ipomea quamoclit, Ephedra distachya, Cinnamonum camphora, Papaver capreolata, Passiflora ... ...

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Spatial Variability of Wave Data from Todos Santos Bay, Baja California, Mexico

... DARPA-MATERIALS RESEARCH COUNCIL La Jolla, California 0DTIC ... I I 3 Figure 5. Schematic representation of DARPA's Initiative in Concurrent ...

1989-08-04

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N45.2.5: construction phase quality assurance requirements for installation, inspection, and testing of structural concrete

... and operation of marine structures and to estimate coastal sediment transport. While the timely collection and report of high ... ...

42

Modelling of tritium behavior in solid breeder blankets of conceptual fusion reactors

(Nov 1973). United States Schierberg, GM San Francisco, California, USA.

1973-11-11

43

Microstructure--mechanical property--fracture relationships in the all-beta titanium alloy Ti--13V--11Cr--3Al

1982. p. 1, Paper 11. United States Kessel, CE Jr. Univ. of California,

1982-03-28

44

Mangroves in the Gulf of California increase fishery yields

1972. United States Narayanan, GH Archbold, TF Univ. of California Press.;

45

Human Interfaces for Robotic Satellite Servicing

Mangroves are disappearing rapidly worldwide despite their well documented biodiversity and the ecosystem services they provide. Failure to link ecological processes and their societal benefits has...Full Text Available

2008-07-29

46

Design of hybrid mobile communication networks for planetary ...

... of China Lake Naval Weapons Center, California. ... Figure 4: The Space-Based Laser cleaning ... of Aeronautics and Astronautics (AIAA) Space 2001 ...

2011-05-13

47

Chewing up the Forest: Bark-Eating Beetles Provide Timber for ...

... California where he is currently working on an AS in. Data Communication & Network Management as well as Microsoft. MCSE and Cisco CCNA certifications.

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Central Coast Region Timber Harvesting Plans

Chewing up the Forest: Bark-Eating Beetles Provide Timber for Forest Fires. Droughts in California allow bark beetles to lay eggs into sapless trees, ...

49

Cape Mendocino, CA Earthquakes, April 25 & 26, 1992 - NASA

This data layer consists of polygons representing harvest area boundaries from Timber Harvest Plans approved by the California Department of Forestry ... ...

50

Berkeley Lab News Center: Today at Berkeley Lab

Two additional earthquakes, magnitudes 6.6 and 6.7 occurred the next morning. The first earthquake was located six miles north of Petrolia, California, ...

51

A Composite Architecture for Network Security at JPL Robert B ...

who was appointed in July to lead the Defense Advanced Research Projects Agency, or DARPA, made visits last week to UC Berkeley, Stanford, UCLA and the California Institute of...

2011-08-27

52

0100127 - Liquid nitrogen dewar for protein crystal growth - NASA

A Composite Architecture for Network Security at JPL. Robert B. Mead, Tom G. Dearmond, and Joseph S. Sherif. JPL, California Institute of Technology ...

53

Radioiodide uptake in brain, CSF, thyroid, and salivary glands of audiogenic seizure mice

Gaseous Nitrogen Dewar apparatus developed by Dr. Alex McPherson of the University of California, Irvine for use aboard Mir and the International Space ...

54

Detection of Visual Deficits in Aging DBA/2J Mice by Two Behavioral Assays

DBA/2J (DBA) mice are susceptible to audiogenic seizures (ASs) in an age-dependent manner. Anion transport as measured by radioiodide uptake was determined in thyroid gland, salivary gland, skeletal muscle, cerebral cortex, cerebellum, brainstem, and CSF from these mice at various ages. Anion transport was also determined in C57BL/6J(C57) mice, an AS-resistant strain. In thyroid, DBA mice had an enhanced ability to concentrate iodide at 21 days of age when they have maximal AS susceptibility, as compared with the same-aged C57 mice. This difference in thyroid function was less marked at 40 days of age, when DBA mice are less AS susceptible, and was absent at 110 days of age, when DBA mice are AS resistant. In brain, differences in iodide uptake were also noted between these two strains of mice at 21 days of age. DBA ...

1984-08-01

55

British Library Electronic Table of Contents (United Kingdom)

Purpose: The DBA/2J mice have been used as an animal model for human pigmentary glaucoma. However, these mice develop various degrees of disease symptoms at different ages, making it difficult to detect pathological changes of retinal degeneration at glaucoma onset. The purpose of this study is to develop a non-invasive assay to identify individual mice that develop visual deficits. Materials and Methods: We apply two behavioral tests, a swimming test of visual discrimination and a test of optomotor response, to identify glaucomatous DBA/2J mice. We then examine whether the elevation of intraocular pressure (IOP), the common risk factor for glaucoma, affects visual performances of the DBA/2J mice. We further compare the retinal ganglion cell death, one of the signature glaucoma symptoms, i...

2011-01-01

56

USE OF ENVIRONMENTAL ISOTOPES TO DIFFERENTIATE WATER SOURCES AND CONSTRAIN THE WATER BUDGET AT THE SULPHUR BANK MERCURY MINE, CLEAR LAKE, CALIFORNIA

Sandia National Laboratories/California site environmental report for 1997

The Sulphur Bank Mercury Mine (SBMM) is a 65 ha site located on the eastern shore of the Oaks Arm of Clear Lake, Lake County, California. Between 1864 and 1957, SBMM was the site of underground and open pit mining operations for S and Hg, coinciding with past and present hot spr...

57

Analysis of environmental regulations governing the disposal of geothermal wastes in California

Sandia National Laboratories (SNL) is committed to conducting its operations in an environmentally safe and sound manner. It is mandatory that activities at SNL/California comply with all applicable environmental statutes, regulations, and standards. Moreover, SNL/California continuously strives to reduce risks to employees, the public, and the environment to the lowest levels reasonably possible. To help verify effective protection of public safety and preservation of the environment, SNL/California maintains an extensive, ongoing environmental monitoring program. This program monitors all significant effluents and the environment at the SNL/California site perimeter. Lawrence Livermore National Laboratory (LLNL) performs off-site external radiation monitoring for both sites. These monitoring efforts ensure that emission controls are effective in preventing contamination of the environment. As part of ...

1998-06-01

58

A combined saline formation and gas reservoir CO2 injection pilotin Northern California

Federal and California regulations governing the disposal of sludges and liquid wastes associated with the production of electricity from geothermal resources were evaluated. Current disposal practices, near/far term disposal requirements, and the potential for alternate disposal methods or beneficial uses for these materials were determined. 36 refs., 3 figs., 15 tabs. (ACR)

1985-09-01

59

Variation in Nicotine Consumption in Inbred Mice Is Not Linked to Orosensory Ability

A geologic sequestration pilot in the Thornton gas field in Northern California, USA involves injection of up to 4000 tons of CO{sub 2} into a stacked gas and saline formation reservoir. Lawrence Berkeley National Laboratory (LBNL) is leading the pilot test in collaboration with Rosetta Resources, Inc. and Calpine Corporation under the auspices of the U.S. Department of Energy and California Energy Commission's WESTCARB, Regional Carbon Sequestration Partnership. The goals of the pilot include: (1) Demonstrate the feasibility of CO{sub 2} storage in saline formations representative of major geologic sinks in California; (2) Test the feasibility of Enhanced Gas Recovery associated with the early stages of a CO{sub 2} storage project in a depleting gas field; (3) Obtain site-specific information to improve capacity estimation, risk assessment, and performance prediction; (4) Demonstrate and test methods for ...

2006-04-28

60

Toxicity and carcinogenicity studies of boric acid in male and female B6C3F1 mice.

Genetic studies of nicotine addiction in mice have utilized the oral self-administration model. However, it is unclear if strain differences in nicotine consumption are influenced by variation in bitter...Full Text Available

2009-01-01

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61

Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

Toxicity and potential carcinogenicity studies of boric acid were investigated in mice to verify in a second rodent species that this was a noncarcinogenic chemical. Earlier chronic studies in rats...Full Text Available

1994-11-01

62

Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice

We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice....Full Text Available

63

RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice

Sensory neurons in aging mammals undergo changes in anatomy, physiology and gene expression that correlate with reduced sensory perception. In this study we compared young and aged mice to identify...Full Text Available

2006-06-01

64

Pulmonary endothelial and bronchiolar epithelial lesions induced by 4-ipomeanol in mice.

BackgroundGlucocorticoids down-regulate cytokine synthesis and suppress inflammatory responses. The glucocorticoid receptor (GR) antagonist RU486 may exacerbate the inflammatory...Full Text Available

65

Protective effects of sparfloxacin in experimental pneumonia caused by Chlamydia pneumoniae in leukopenic mice.

The morphogenesis of pulmonary edema and bronchiolar injury induced by the toxic furan, 4-ipomeanol, was studied by combined light and transmission electron microscopy. Weanling male CD-1 mice received...Full Text Available

1985-01-01

66

Of mice and rats: key species variations in the sexual differentiation of brain and behavior

The in vivo antichlamydial activities of sparfloxacin and reference drugs were examined in a experimental model of pneumonia caused by Chlamydia pneumoniae in leukopenic mice; their in vitro activities...Full Text Available

1994-08-01

67

Nitric Oxide-Mediated Tumoricidal Activity of Murine Microglial Cells12

Mice and rats are important mammalian models in biomedical research. In contrast to other biomedical fields, work on sexual differentiation of brain and behavior has traditionally utilized comparative...Full Text Available

2010-07-01

68

New strain of mouse hepatitis virus as the cause of lethal enteritis in infant mice.

Experimental metastases in the brain of mice are infiltrated by microglia, and parabiosis experiments of green fluorescent protein (GFP⁺) and GFP^- mice revealed that these microglia...Full Text Available

69

Lung delayed-type hypersensitivity in stressed mice.

A new strain of mouse hepatitis virus (MHV) was isolated from pooled gut suspensions from an epizootic of lethal enteritis in newborn mice. Negative-contrast electron microscopy showed an abundance...Full Text Available

1979-05-01

70

Localization of a critical restriction site on the I-A beta chain that determines susceptibility to collagen-induced arthritis in mice.

The influence of an immobilization stressor on lung cellular immune responses was studied. Delayed-type hypersensitivity to sheep erythrocytes was used to evaluate in vivo lung cellular immunity. Mice...Full Text Available

1984-04-01

71

Life Span Extension in Mice by Food Restriction Depends on an Energy Imbalance12

Type II collagen-induced arthritis (CIA) in mice is an autoimmune experimental model for rheumatoid arthritis. Susceptibility to CIA is associated with certain major histocompatibility complex class...Full Text Available

1989-12-01

72

Inheritable Effect of Unpredictable Maternal Separation on Behavioral Responses in Mice

In this study, our main objective was to determine whether energy restriction (ER) affects the rate of oxygen consumption of mice transiently or lastingly and whether metabolic rate plays a role in...Full Text Available

2009-03-01

73

In vitro assay for curative activity in blood of mice infected with Trypanosoma musculi.

The long-term impact of early stress on behavior and emotions is well documented in humans, and can be modeled in experimental animals. In mice, maternal separation during early postnatal development...Full Text Available

74

Impact of Lifelong Sedentary Behavior on Mitochondrial Function of Mice Skeletal Muscle

An in vitro assay for curative antibody present in plasma of mice cured of Trypanosoma musculi is described. The assay involves the addition of plasma to a sample of infected blood, followed by hourly...Full Text Available

1986-08-01

75

Heterogeneity of engrafted bone-lining cells after systemic and local transplantation

This study investigated the impact of lifelong sedentariness on skeletal muscle mass and mitochondrial function. Thirty C57BL/6 strain mice (2 months) were randomly divided into three groups (young-Y;...Full Text Available

2009-09-01

76

Germline mutagenesis mediated by Sleeping Beauty transposon system in mice

The outcome of various osteoprogenitor-cell transplantation protocols was assessed using Col1a1-GFP reporter transgenic mice. The model requires the recipient mice to undergo lethal total body irradiation...Full Text Available

2005-11-15

77

Expression of embryonic hemoglobin genes in. cap alpha. -thalassemic and in. beta. -duplication mice

Following the descovery of its transposition activity in mammalian culture systems, the Sleeping Beauty (SB) transposon has since been applied to achieve germline mutagenesis in mice....Full Text Available

2007-01-01

78

Effect of long-term caloric restriction on oxygen consumption and body temperature in two different strains of mice

The results of a study of the expression of embryonic hemoglobin genes in mice which show an imbalance of alpha and non-alpha chain synthesis are reported. (ACR)

1979-01-01

79

De Novo Induction of Genetically Engineered Brain Tumors In Mice Using Plasmid DNA

The hypothesis, that a decrease in metabolic rate mediates the life span prolonging effect of caloric restriction (CR), was tested using two strains of mice, one of which, C57BL/6, exhibits...Full Text Available

2007-10-01

80

Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone.

Spontaneous mouse models of cancer show promise to more accurately recapitulate human disease and predict clinical efficacy. Transgenic mice or viral vectors have been required to generate spontaneous...Full Text Available

2009-01-15

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81

Chapter 61: Photoreceptor Cell Degeneration in Abcr^?/? Mice

We introduce cyclophosphamide-induced alopecia (CYP-IA) in C57BL-6 mice as a clinically relevant model for studying the biology of chemotherapy-induced alopecia and for developing anti-alopecia drugs....Full Text Available

1994-04-01

82

Cell kinetics of growth cartilage of achondroplastic (cn) mice.

Mice harboring a null mutation in Abca4/Abcr serve as a model of autosomal recessive Stargardt disease. Consistent with the human retinal disorder, deficiency...Full Text Available

2010-01-01

83

Ameliorative Potential of Quercetin Against Paracetamol-induced Oxidative Stress in Mice Blood

Mice homozygous for the recessive gene achondroplasia (cn) aged 16 and 17 days and some homozygotes aged 22-34 days have disruptions in the growth of the proximal tibial growth plate which are due solely...Full Text Available

1985-05-01

84

Regulation of the expression of the apolipoprotein(a) gene : Evidence for a regulatory role of the 5' distal ACR enhancer in YAC transgenic mice

The aim of the present study was to evaluate the ameliorative potential of quercetin (QC) against paracetamol (PCM)-induced oxidative stress and biochemical alterations in mice blood. A total of 36...Full Text Available

2011-07-01

85

Inhibition of melanoma growth by subcutaneous administration of hTERTC27 viral cocktail in C57BL/6 mice.

No abstract prepared.

2003-01-30

86

Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2

PMID:20856939

2010-09-13

87

The incidence of spontaneously occurring antiliver antibodies in New Zealand Black mice

We reported previously that Fas-induced hepatic failure in normal mice was attenuated or prevented by exogenous transferrin (Tf), particularly apoTf. Here we show in C57BL6J/129 mice with genetic...Full Text Available

2008-08-01

88

Instrument of millimetre wave radiation and its effect on malignant tumor in mice and its application in clinic

The sera of NZB/BL mice have been found to be active in the complement fixation test against isogeneic liver antigens to a higher titre than the sera of CBA, C57BL and DBA/2 mice. Six sera from NZB...Full Text Available

1969-04-01

89

Inbred Strain-Specific Effects of Exercise in Wild Type and Biglycan Deficient Mice

An animated test is made for mice with malignant tumors irradiated by a self-made millimetre wave radiator for medical purpose. It is observed that S-180 sarcomas in mice after irradiation has been distinctly suppressed. And remarkable effects are shown through a lot of clinical practices on peptic ulcer, skin-deep ulcer, acute and chromic soft tissue injuries etc.

1995-12-31

90

EFFECT OF SODIUM PENTOBARBITAL ON BEHAVIORAL THERMOREGULATION IN RATS AND MICE

Biglycan (bgn)-deficient mice (KO) have defective osteoblasts which lead to changes in the amount and quality of bone. Altered tissue strength in C57BL6/129 (B6;129) KO mice, a property which...Full Text Available

2010-04-01

91

An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice

The experiment was designed to study the effects of sodium pentobarbital on behavioral thermoregulation in rats and mice. Male Sprague-Dawley rats were given intraperitoneal (i.p.) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male CBA/J mice were giv...

92

Manganese-Induced NF-kB Activation and Nitrosative Stress Is Decreased by Estrogen in Juvenile Mice

It has been postulated that fetal vascular abnormalities in aryl hydrocarbon receptor null (ahr^−/−) mice may alter cardiovascular homeostasis in adulthood....Full Text Available

2010-07-15

93

British Library Electronic Table of Contents (United Kingdom)

Manganese toxicity can cause a neurodegenerative disorder affecting cortical and basal ganglia structures with a neurological presentation resembling features of Parkinson's disease. Children are more sensitive to Mn-induced neurological dysfunction than adults, and recent studies from our laboratory revealed a marked sensitivity of male juvenile mice to neuroinflammatory injury from Mn, relative to females. To determine the role of estrogen (E2) in mediating sex-dependent vulnerability to Mn-induced neurotoxicity, we exposed transgenic mice expressing an NF-kB-driven enhanced green fluorescent protein (EGFP) reporter construct (NF-kB-EGFP mice) to Mn, postulating that supplementing male mice with E2 during juvenile development would attenuate neuroinflammatory changes associated with glia...

2011-01-01

94

Laboratory evaluation of the hazard to wood mice, Apodemus sylvaticus, from the agricultural use of methiocarb molluscicide pellets

Web-based tools for modelling and analysis of multivariate data: California ozone pollution activity

Laboratory studies have been carried out to determine the toxicity of methiocarb pellets to wild trapped wood mice in order to provide some background data prior to any further evaluation of hazard in the field. In this study, wood mice were exposed to dry and to dampened methiocarb pellets in order to reproduce field trial application conditions. Field observations of methiocarb pellets indicate that the physical character changes under dry and wet weather conditions. This may affect their relative attractiveness and potential toxicity to wood mice. The laboratory assessment of exposed wood mice included measurement of brain esterase activities, methiocarb residues in selected mouse tissue, carcasses, and histological evaluation of kidney, liver and lungs.

1988-01-01

95

British Library Electronic Table of Contents (United Kingdom)

This article presents a hands-on web-based activity motivated by the relation between human health and ozone pollution in California. This case study is based on multivariate data collected monthly at 20 locations in California between 1980 and 2006. Several strategies and tools for data interrogation and exploratory data analysis, model fitting and statistical inference on these data are presented. All components of this case study (data, tools, activity) are freely available online at: http://wiki.stat.ucla.edu/socr/index.php/SOCR_MotionCharts_CAOzoneData. Several types of exploratory (motion charts, box-and-whisker plots, spider charts) and quantitative (inference, regression, analysis of variance (ANOVA)) data analyses tools are demonstrated. Two specific human health related questions...

2011-01-01

96

Enhancing the Delivery of Supplemental Nutrition Assistance Program Education through Geographic Information Systems

British Library Electronic Table of Contents (United Kingdom)

The Network for a Healthy California (Network) employs a Geographic Information System (GIS) to identify the target audience and plan program activities because GIS is a powerful tool for assisting in data integration and planning. This paper describes common uses of GIS by Network contractors as well as demonstrating the possibilities of GIS as a useful tool for public health programs and audience targeting in general. Narrative examples supported with graphics describe how 1) Network contractors use the GIS to identify eligible census tracts to carry out their work, 2) the GIS can map neighborhood assets in eligible census tracts throughout California, 3) the GIS can map health behavior data to the county level throughout California, and 4) the GIS can map selected indicators of healthy ...

2011-01-01

97

Energy Engineering Analysis Program, Limited Energy Study, Fort Hunter-Liggett, California. Volume I

Transmission cycles of Borrelia burgdorferi and B. bissettii in relation to habitat type in northwestern California

This report summarizes all work of the Limited Energy Study, Energy Engineering Analysis Program (EEAP), Fort Hunter Liggett, California, authorized under Contract Number DACA05-92-C-0155 with the U.S. Army Corps of Engineers, Sacramento District, California. The purpose of this study is to develop projects and actions that will reduce facilities energy consumption and operating costs at Fort Hunter Liggett. Implementation of these projects will contribute to achieving the goal of the Army Facilities Energy Plan of a reduction in energy consumption per square foot of building floor area of 20 percent by FY2000 from FY1985 baseline levels.

1993-07-01

98

Superconductivity in the pseudo-binary A-15 compounds Mosub(3)Ossub(1-x)Rusub(x) and Mosub(3)Irsub(1-x)Rusub(x)

This study was undertaken to determine which rodent species serve as primary reservoirs for the Lyme disease spirochete Borrelia burgdorferi in commonly occurring woodland types...Full Text Available

2009-06-01

99

Structure and Composition of the Polychaete Community from Bahia San Quintin, Pacific Coast of Baja California, Mexico

(15 Dec 1972). United Kingdom Johnston, DC California Univ., La Jolla (USA).

100

SUN WORSHIPER: McCready's Solar Challenger flies over the English Channel

... poly-chaete densities and diversity values, probably the oyster aquaculture in BF although not intensive has produced a ... faster (Díaz-Castañeda & Rodriguez-Villanueva 1998). However if oyster aquacultu...

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101

Resistance to sexual assault: who resists and what happens?

The background for the project of a solar-powered aircraft, designed and built by Dr. Paul McCready of California, is reported with details on the aircraft design and its flight across the English Channel.

1983-12-01

102

Quality-of-Life and Surgical Treatments for Rectal Cancer-a Longitudinal Analysis Using the California Cancer Registry

To determine who resists sexual assault and what happens, data were examined from a probability sample of 3,132 adult community residents of Los Angeles, California. Seventy-five per cent of the respondents...Full Text Available

1989-01-01

103

Process Waste Assessment for inorganic solid waste and empty containers <30 gallons

BackgroundHeterogeneous results for research investigating health-related quality of life (HRQL) in patients undergoing sphincter-ablating procedures for rectal cancer...Full Text Available

2010-08-01

104

Prevention of clinical coliform mastitis in dairy cows by a mutant Escherichia coli vaccine.

This Process Waste Assessment was conducted to evaluate the two largest hazardous waste streams generated on-site at Sandia National Laboratory (SNL)/California -- ``Other Inorganic Solid Waste`` and ``Empty Containers <30 Gallons.``

1993-12-01

105

Prediction method abstracts

A prospective cohort study was undertaken in two commercial California dairies. The treatment group, 246 cows, received three doses of a whole cell bacterin of J5 Escherichia coli (mutant of E. coli...Full Text Available

1989-07-01

106

Population Structure of the Lyme Borreliosis Spirochete Borrelia burgdorferi in the Western Black-Legged Tick (Ixodes pacificus) in Northern California ?

This conference was held December 4--8, 1994 in Asilomar, California. The purpose of this meeting was to provide a forum for exchange of state-of-the-art information concerning the prediction of protein structure. Attention if focused on the following: comparative modeling; sequence to fold assignment; and ab initio folding.

1994-12-31

107

Methanogen Diversity Evidenced by Molecular Characterization of Methyl Coenzyme M Reductase A (mcrA) Genes in Hydrothermal Sediments of the Guaymas Basin

Factors potentially contributing to the lower incidence of Lyme borreliosis (LB) in the far-western than in the northeastern United States include tick host-seeking behavior resulting in fewer human...Full Text Available

2009-11-01

108

Is the Kaiser Permanente model superior in terms of clinical integration?: a comparative study of Kaiser Permanente, Northern California and the Danish healthcare system

The methanogenic community in hydrothermally active sediments of Guaymas Basin (Gulf of California, Mexico) was analyzed by PCR amplification, cloning, and sequencing of methyl coenzyme M reductase...Full Text Available

2005-08-01

109

Feynman lectures on physics, quantum mechanics; Le cours de physique de Feynman mecanique quantique

BackgroundIntegration of medical care across clinicians and settings could enhance the quality of care for patients. To date, there is limited data on the levels of integration in...Full Text Available

110

Energizing the batteries for electric cars

This course is based upon lectures in physics given by Professor Feynman at the California institute of technology during 1961 and 1962. This volume is dedicated to quantum physics, semiconductors, symmetry and advanced principles of physics.

2000-07-01

111

Dr. Ellen Ochoa - Welcome to Latina Women of NASA home page

This article reports of the nickel-metal-hydride battery and its ability to compete with the lead-acid battery in electric-powered vehicles. The topics of the article include development of the battery, the impetus for development in California environmental law, battery performance, packaging for the battery's hazardous materials, and the solid electrolyte battery.

1993-07-01

112

Agile Energy Systems. Global Lessons from the California Energy Crisis

Feb 28, 2001 ... Dr. Ellen Ochoa was born on May 10, 1958 in Los Angeles, CA, but considers Las Mesa, California to be her hometown. She received her ...

113

A-Train 2010 Abstract Submissions - NASA

Due to the recent catastrophic energy system failures in California along with those in the North-Eastern US and Southern Canada, London, and Italy, the time has come to proclaim the failure of deregulation, privatization or liberalization and propose a new energy system. This book shows in the first section, how five precipitating forces led to the deregulation debacle in California: (1) major technological changes and commercialization, (2) regulatory needs mismatched to societal adjustments, (3) inadequate and flawed economic models, (4) lack of vision, goals, and planning leading to energy failures, and (5) failure and lack of economic regional development. The second half of the book, examines how 'civic market', new economic models, and planning for complexity as sustainable economic development transformed in California, the same five forces to create an 'agile energy system' based ...

2004-09-01

114

Atmospheric carboxylic acids in southern California

particle mass with diameter smaller than 2.5 microns.) Our expectation has been that California's ...... MODIS Aqua and Terra products to visualize the movement of ...... correlation in hydrometeor (cloud and precipitation) occurrence, ...

115

Advanced Power Electronics Interfaces for Distributed Energy Workshop Summary: August 24, 2006, Sacramento, California

Intensive measurements of organic acids, inorganic acids, aldehydes and peroxyacetyl nitrate (PAN) in urban air were carried out at a Southern California smog receptor site, Glendora, CA, August 12-22, 1986. The objective of this project was to augment the data base regarding organic acids in urban air and to assess their role with emphasis on ambient levels, diurnal variations, phase distribution, emissions, in-situ formation and removal. The relative abundance of organic acids and inorganic acids was determined for the first time from simultaneous measurements carried out during this study.

1988-09-01

116

Interactions between the chemotherapeutic agent eribulin mesylate (E7389) and P-glycoprotein in CF-1 abcb1a-deficient mice and Caco-2 cells

The Advanced Power Electronics Interfaces for Distributed Energy Workshop, sponsored by the California Energy Commission Public Interest Energy Research program and organized by the National Renewable Energy Laboratory, was held Aug. 24, 2006, in Sacramento, Calif. The workshop provided a forum for industry stakeholders to share their knowledge and experience about technologies, manufacturing approaches, markets, and issues in power electronics for a range of distributed energy resources. It focused on the development of advanced power electronic interfaces for distributed energy applications and included discussions of modular power electronics, component manufacturing, and power electronic applications.

2006-10-01

117

British Library Electronic Table of Contents (United Kingdom)

Eribulin is a new anticancer agent currently in Phase III clinical trials for the treatment of metastatic breast cancer. In the current studies, we have investigated the effects of P-glycoprotein (P-gp) on the in vivo disposition of eribulin using CF-1 abcb1a-deficient mice, and the influence of eribulin on P-gp-mediated efflux of digoxin in Caco-2 cells. Eribulin was administered intravenously and orally in both CF-1 wild-type and CF-1 abcb1a-deficient mice. P-gp-mediated efflux of digoxin in Caco-2 cell monolayers was measured in the presence of eribulin. The plasma exposure to eribulin was higher in CF-1 abcb1a-deficient mice than that in CF-1 wild-type mice after intravenous (IV) and oral (PO) administrations. The oral bioavailability of eribulin was 62.3% in CF-1 abcb1a-deficient mice...

2011-01-01

118

Changes in cell proliferation kinetics in the mouse cerebellum after total asphyxia

Systemic responses to inhaled ozone in mice: cachexia and down-regulation of liver xenobiotic metabolizing genes

This study was undertaken to investigate the effects of neonatal asphyxia on brain development, with special reference to the kinetics of neuronal proliferation by using autoradiography. For 30 minutes, two-day-old suckling mice, Jcl:ICR strain, were put into a chamber which was constantly flushed with 100% CO_2 gas. After the exposure to asphyxia, 29% of the mice survived. Cell cycle studies were carried out at two days and at seven days on the external matrix cells, the precursor of the granule cells, at the external granular layer of the cerebellum from CO_2-exposed and control mice by "3H-thymidine autoradiography. At two days the generation time of the control mice was about 15 hours, whereas that of the asphyxiated mice was about 17 hours. The prolongation of the generation time in the asphyxiated mice was caused mainly by a delay in the G2 phase. This ...

119

Role of Obesity in Prostate Cancer Development

Rats or mice acutely exposed to high concentrations of ozone show an immediate and significant weight loss, even when allowed free access to food and water. The mechanisms underlying this systemic response to ozone have not been previously elucidated. We have applied the technique of global gene expression analysis to the livers of C57BL mice acutely exposed to ozone. Mice lost up to 14% of their original body weight, with a 42% decrease in total food consumption. We previously had found significant up-regulation of genes encoding proliferative enzymes, proteins related to acute phase reactions and cytoskeletal functions, and other biomarkers of a cachexia-like inflammatory state in lungs of mice exposed to ozone. These results are consistent with a general up-regulation of different gene families responsive to NF-#kappa#B in the lungs of the exposed mice. In the present study, we ...

2005-10-15

120

RBE of the MIT Epithermal Neutron Beam for Crypt Cell Regeneration in Mice

... estrogen receptor status. Cancer Lett., 253, 291-300. 39. Xin,X ... and resistant mice. Brain Res.Bull., 52, 235-242. 40. Foster,BA ...

2011-04-01

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121

Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1

... these estimates were obtained from these and the parameter covariance matrix using a parametric bootstrap method. We present the ... ...

122

Laser Photobiomodulation of Wound Healing in Diabetic and Non-Diabetic Mice: Effects in Splinted and Unsplinted Wounds

An intact basement membrane (BM) is essential for the proper function, differentiation and morphology of many epithelial cells. The disruption or loss of this BM occurs during normal development as well as in the disease state. To examine the importance of BM during mammary gland development in vivo, we generated transgenic mice that inappropriately express autoactivating isoforms of the matrix metalloproteinase stromelysin-1. The mammary glands from these mice are both functionally and morphologically altered throughout development. We have now documented a dramatic incidence of breast tumors in several independent lines of these mice. These data suggest that overexpression of stromelysin-1 and disruption of the BM may be a key step in the multi-step process of breast cancer.

1995-06-01

123

British Library Electronic Table of Contents (United Kingdom)

Abstract Objective: The aim of this investigation was to compare the healing of laser-irradiated and non-irradiated wounds covered by an occlusive dressing in mice. Background data: Many previous studies of the effects of laser irradiation of experimental wounds in mice and rats did not cover the wounds so that healing occurred mainly by contraction. Healing of covered wounds is slower and mimics more closely wound healing in humans. Materials and Methods: Forty-seven diabetic and twenty non-diabetic mice were used. A single wound (5?mm diameter) was created on the left flank of each animal and covered by Tegaderm HP dressing (Day 1). Wounds were irradiated (660?nm) for 20?s using a lower power (18?mW) or higher power (80?mW) laser starting immediately post-wounding for seven consecutive d...

2010-01-01

124

Histological analysis of 70-nm silica particles-induced chronic toxicity in mice

British Library Electronic Table of Contents (United Kingdom)

Nano-sized silica is a promising material for disease diagnosis, cosmetics and drugs. For the successful application of nano-sized material in bioscience, evaluation of nano-sized material toxicity is important. We previously found that nano-sized silica particles with a diameter of 70nm showed acute liver failure in mice. Here, we performed histological analysis of major organs such as the liver, spleen, lung, kidney, brain and heart in mice, chronically injected with 70-nm silica particles for 4weeks. Histological analysis revealed hepatic microgranulation and splenic megakaryocyte accumulation in these 70-nm silica particles treated mice, while the kidney, lung, brain and heart remained unaffected. Thus, liver and spleen appear to be the major target organs for toxicity by the chronic a...

2009-01-01

125

Effects of Green Tea Seed Oil on the Cholesterol, TBARS and Inflammatory Responses in C57BL/6 Mice Fed High Cholesterol Diet

Bladder outlet obstruction in male cystinuria mice

Full Text Available

2007-03-01

126

Avoidance of hydrolyzed casein by mice

BackgroundCystinuria is the most common inherited cause of urinary tract stones in children. It can lead to obstructive uropathy, which is a major cause of renal...Full Text Available

2010-03-01

127

California and western region geothermal heat pump training center

When casein, a milk protein, is hydrolyzed, it renders human foods that contain it (e.g., hypoallergenic infant formula, cheeses) distasteful to many people. This rejection...Full Text Available

2008-01-28

128

Urethral carcinoma and hyperplasia in male and female B6C3F1 mice treated with 3,3?,4,4?- Tetrachloroazobenzene (TCAB)

The Geothermal Energy Association ({open_quotes}GEA{close_quotes}) will create and manage a Geothermal Heat Pump ({open_quotes}GHP{close_quotes}) Training Center to deliver GHP and HVAC courses throughout California in response to imminent demand driven by national promotion. GEA services include providing management structure, cadre, curricula, promotion and physical equipment. The Center is dedicated to infrastructure strengthening goals of the Geothermal Heat Pump Consortium, Inc. ({open_quotes}GHPC{close_quotes}), the California Energy Commission ({open_quotes}CEC{close_quotes}) and Interagency Geothermal Heat Pump Task Force, and Geothermal Energy Association ({open_quotes}GEA{close_quotes}). Second-half 1996 start-up is co-funded by GHPC, CEC, GEA and three California utilities. Initial support is to five utilities representing 70 percent of California power users. Goals include becoming market ...

1996-12-31

129

Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality

B6C3F1 mice chronically exposed to 3,3′,4,4′-tetrachloroazobenzene (TCAB), a contaminant of dichloroaniline-derived herbicides, developed a number of neoplastic and nonneoplastic...Full Text Available

2010-01-01

130

Taste-Evoked Responses to Sweeteners in the Nucleus of the Solitary Tract Differ between C57BL/6ByJ and 129P3/J Mice

When the vehicle-treated, sham-operated mice underwent heat stress, the fraction survival and core temperature at +4 h of body heating were found to be 5 of 15 and 34.4°C ± 0.3°C,...Full Text Available

2010-01-01

131

Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and long-term studies in mice

C57BL/6ByJ (B6) and 129P3/J (129) mice have different alleles of Tas1r3, which is thought to influence gustatory transduction of sweeteners, but studies have provided conflicting...Full Text Available

2007-01-03

132

Overview of the activity of a Brucella abortus preparation, Bru-Pel.

Short and long-term pulmonary response to inhaled nickel hydroxide nanoparticles (nano-Ni(OH)₂, CMD = 40 nm) in C57BL/6 mice was assessed using a whole body exposure system. For short-term...Full Text Available

2010-03-01

133

Morphological, Histochemical, Immunohistochemical, and Ultrastructural Characterization of Tumors and Dysplastic and Non-Neoplastic Lesions Arising in BK Virus/tat Transgenic Mice

The properties of a nonviable, aqueous ether-extracted Brucela abortus preparation, Bru-Pel, are described. In addition to inducing a "virus-type" interferon response and protecting mice against challenge with otherwise lethal doses of Semliki Forest virus, Bru-Pel is demonstrated to have potent antitumor properties in mice. These antitumor effects appear to be mediated by an increase in nonspecific resistance similar to that seen with other experimental antitumor agents. PMID:728911

1978-11-01

134

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.

To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA...Full Text Available

1999-04-01

135

Metabolomics in Lung Inflammation: A High Resolution ¹H NMR Study of Mice Exposed to Silica Dust

We have recently shown that viable Borrelia burgdorferi organisms induce a chronic infection associated with arthritis and carditis in severe combined immunodeficiency (scid) mice but not in immunocompetent...Full Text Available

1990-05-01

136

Influence of steroidal and nonsteroidal sex hormones on host resistance in mice: increased susceptibility to Listeria monocytogenes after exposure to estrogenic hormones.

Here we report the first ¹H NMR metabolomics studies on excised lungs and bronchoalveolar lavage fluid (BALF) from mice exposed to crystalline silica. High resolution ¹H...Full Text Available

2008-01-01

137

Effects of xylitol on the absorption of /sup 203/Pb in mice and cockerels

Subchronic exposure to pharmacological levels of estrogenic compounds, including 17 beta-estradiol, diethylstilbestrol, and alpha-dienestrol, significantly increased the mortality of B6C3F1 female mice...Full Text Available

1984-11-01

138

Both the Fas Ligand and Inducible Nitric Oxide Synthase Are Needed for Control of Parasite Replication within Lesions in Mice Infected with Leishmania major whereas the Contribution of Tumor Necrosis Factor Is Minimal

Earlier studies have indicated that xylitol may increase the absorption and urinary excretion of dietary oxalate. It has also been indicated that xylitol increases the absorption of calcium. Intestinal absorption of lead, a divalent contaminant in the diet, is in many respects similar to that of calcium. The purpose of this study was to evaluate the effects of xylitol on the intestinal absorption of lead using two different approaches: the in situ ligated intestinal loop technique in cockerels and gastric gavage in mice.

1986-07-01

139

Following infection with the protozoan parasite Leishmania major, C57BL/6 mice develop a small lesion that heals spontaneously. Resistance to infection is associated with the development...Full Text Available

2003-09-01

140

Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice

PurposePrevious studies have demonstrated that in 129α3Cx46^−/− mice, age-related nuclear cataract is formed. In...Full Text Available

2007-06-01

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141

British Library Electronic Table of Contents (United Kingdom)

Cholestatic liver injury induced by alpha-naphthylisothiocyanate (ANIT) is provoked by injury to intrahepatic bile ducts and the progression of hepatic necrosis requires the procoagulant protein tissue factor (TF) and extrahepatic cells including neutrophils. Recent studies have shown that myeloid cell TF contributes to neutrophil activation. We tested the hypothesis that myeloid cell TF contributes to neutrophil activation in ANIT-treated mice. TF activity in liver homogenates increased significantly in TF^f^l^o^x^/^f^l^o^x mice treated with ANIT, but not in TF^f^l^o^x^/^f^l^o^x/LysMCre mice (TFD^M^y^e^l^o^i^d mice), which have reduced TF expression in monocytes/macrophages and neutrophils. Myeloid cell-specific TF deficiency did not alter expression of the chemokines KC or MIP-2 but redu...

2011-01-01

142

Hemoglobin of mice with radiation-induced mutations at the hemoglobin loci

Effect of pentachlorophenol on the activation of 2,6-dinitrotoluene to genotoxic urinary metabolites in CD-1 mice: A comparison of G1 enzyme activities and urine mutagenicity

Chemical analyses were done on the abnormal hemoglobins of the five (101 x SEC)F_1 offspring of X- irradiated adult SEC mice to determine which hemoglobin genes were expressed in each hemoglobin variant. Three offspring of irradiated SEC males did not express either of the two kinds of #alpha#-chains normally found in all SEC mice. The deficient #alpha#-chain synthesis caused these mice to exhibit an #alpha#-thalassemia similar to human #alpha#-thalassemia. Scanning electron microscopy was used to show that many erythrocytes of mice with #alpha#-thalassemia have bizarre shapes; e.g. many erythrocytes appeared flattened or had thorny projections (acanthocytes). One mutant with a tandem duplication of a segment of chromosome 7 (site of locus determining #beta#-chain structure) produced twice as much SEC as 101 #beta#-chain polypeptides. One mutant that probably arose by non-disjunction of chromosome 7's ...

143

A verification of previously identified QTLs for cocaine-induced activation using a panel of B6.A chromosome substitution strains (CSS) and A/J x C57Bl/6J F2 mice

2,6-Dinitrotoluene (2,6-DNT) and pentachlorophenol (PCP) are used for industrial purposes and are found in the environment as hazardous contaminants. Because concurrent exposure to both compounds can occur, it is of interest to determine if organochlorine compounds potentiate the effect of nitroaromatic chemicals. A significant increase in mutagenicity was observed in urines from mice treated with 2,6-DNT alone and in combination with PCP. By week 4, mice that received both 2,6-DNT and PCP excreted urine that was more mutagenic than that from animals which received only 2,6-DNT. At weeks 2 and 4, mice were sacrificed and intestinal enzyme activities (nitroreductase, azo reductase, {beta}-glucuronidase, dechlorinase, and dehydrochlorinase) were quantitated. The enhanced genotoxicity observed in urines from 2,6-DNT/PCP-treated mice coincided with a decrease in nitroreductase and an increase in ...

1991-01-01

144

British Library Electronic Table of Contents (United Kingdom)

Background The objective of this study was to confirm provisional quantitative trait loci (QTL) for cocaine-induced locomotor activation, on chromosomes 1, 5, 6, 9, 12, 15, 16, 17, and 18, previously identified in the AXB/BXA recombinant inbred (RI) and AcB/BcA recombinant congenic (RC) strains of mice derived from A/J (A) and C57BL/6J (B6) progenitors. This was accomplished through a genetic analysis of cocaine-induced activity in an AxB6 F2 cross and a phenotypic survey across a panel of B6.A chromosome substitution strains (CSS) mice. Mice were tested for cocaine-induced activity, following administration of saline and cocaine (20?mg/kg), utilizing an open-field procedure. Results Among AxB6 F2 mice, differences in cocaine-induced activity were associated with loci on chromosome 1 (D1Mi...

2009-01-01

145

The Power Industry Reform and the lesson from California Situation

Residence time probability analysis of sulfur concentrations at Grand Canyon National Park

What kind of lesson do we get from California situation? The first is that the sufficient investment to the operational regulation should be prepared as a system. It is necessary to introduce the systems related to capacity, such as the capacity market system that makes retail suppliers secure the fixed rate of their running peak-load as reserve capacity and other system that secure the 5-year supply capacity by a contract, in which suppliers can pay the penalty if they purchase more capacity than in the contract. The second is that the supplementary measures should be systematized for the supply system not to be in a panic in a case of the shortage situation of equipment. The exchange authority should control the regular inspection program on generators to reduce the market control of the supply companies. Through the supplementary system, the increase of electricity price must make the demand decrease. According to the current plan, it will be take a long time to ...

2001-03-01

146

Molecular epidemiology of childhood leukemia with emphasis on chemical exposures

A statistical method is developed to determine the locations of major pollutant sources affecting a distant downwind receptor, provided that air trajectories can be estimated. Probability density functions are estimated which indicate the overall residence time of air parcels over a given geographic region as they travel toward a receptor and residence time for the case of high pollutant concentrations at the receptor. These functions are used to estimate a conditional probability function which indicates the potential for a source region to contribute to high air pollution concentrations. Finally, a source contribution function is formulated to indicate the relative contribution of different source regions to high concentrations at the receptor. The method is tested using data collected at Grand Canyon National Park in 1980. The dominant pathway for air masses arriving at Grand Canyon during this period was southern California. A lesser pathway was from the border ...

1985-01-01

147

Well log interpretation of certain geothermal fields in the Imperial Valley, California

Developing markets in the Pacific Basin depend heavily on the production and export of consumer goods. The generation of hazardous waste as a by-product of industrial production can be linked to adverse health outcomes, such as childhood leukemia, in ways that are presently unknown. In California, exposures resulting from hazardous waste disposal are of concern in the etiology of childhood cancer. Approximately 63% of the 57 hazardous waste sites that the U.S. Environmental Protection Agency (USEPA) included in the national priority list under the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) statute were in the six-county San Francisco Bay area. This area includes California`s Silicon Valley, where a disproportionate majority of these sites are located. Although only one study links hazardous waste disposal to childhood leukemia evidence is accumulating that in utero and maternal pesticide exposures as well as ...

1996-12-31

148

Usage pattern of personal care products in California households

This study reviews the wireline log responses of some geothermal fields in the Imperial Valley, California. The fields under study include the Heber, the East Mesa, the Brawley, and the Westmoreland. The well logs used in the study did not include all the wireline surveys obtained by the operators. The selected well logs obtained under special arrangements with the operators were chosen to maintain the anonymity of specific well locations but are only representative of each area. Analysis of the well logs indicates that on an individual field basis, the well logs are excellent for correlation purposes. The presence of extremely saline fluids in some fields precludes the monitoring of Q/sub v/ (cation exchange capacity per unit volume) profile for detection of hydrothermally altered zones. The producing sections in all the fields are characterized by low porosity and high resistivity.

1984-03-01

149

British Library Electronic Table of Contents (United Kingdom)

Given the concern over the potential for health risks associated with certain ingredients (e.g., phthalates) in personal care products, usage patterns of 30 types of personal care products (e.g., shampoo, sunscreen, fragrance, etc.) were collected in 604 California households through a telephone interview. Preferences in selecting products, e.g., scented or unscented, aerosol, and brand loyalty, were also investigated. Participants were recruited in three age groups, children (mostly preschoolers), their parents, and adults age 55 or older. Use frequencies of various product types varied by sex, age group, race, education, and climatic region. Product use by parent and child from the same household were correlated. Use frequencies of products in the same class (e.g., skincare) were moderat...

2010-01-01

150

Telephone Flat Geothermal Development Project Environmental Impact Statement Environmental Impact Report. Final

Seasonal and habitat abundance and distribution of some forensically important blow flies (Diptera: Calliphoridae) in Central California

This Final Environmental Impact Statement and Environmental Impact Report (Final EIS/EIR) has been prepared to meet the requirements of the National Environmental Policy Act (NEPA) and the California Environmental Quality Act (CEQA). The Proposed Action includes the construction, operation, and decommissioning of a 48 megawatt (gross) geothermal power plant with ancillary facilities (10-12 production well pads and 3-5 injection well pads, production and injection pipelines), access roads, and a 230-kilovolt (kV) transmission line in the Modoc National Forest in Siskiyou County, California. Alternative locations for the power plant site within a reasonable distance of the middle of the wellfield were determined to be technically feasible. Three power plant site alternatives are evaluated in the Final EIS/EIR.

1999-02-01

151

British Library Electronic Table of Contents (United Kingdom)

Seasonal and habitat calliphorid abundance and distribution were examined weekly for two years (2001-2003) in Santa Clara County, California, using sentinel traps baited with bovine liver. Of the 34,389 flies examined in three defined habitats (rural, urban, and riparian), 38% of the total catch represented Compsomyiops callipes (Bigot) and 23% represented Phormia regina (Meigen). Other flies collected in this survey included Calliphora vomitoria (Linnaeus), Calliphora latifrons (Hough), Lucilia sericata (Meigen), Lucilia cuprina (Wiedemann), and Lucilia mexicana (Macquart), which is a new record for the area. Multivariate MANOVA and ANOVA (P 0.05) analysis indicate significant seasonal habitat preference for all fly species examined. This information may be used to identify potentially fo...

2011-01-01

152

Reconnaissance radiological characterization for the White Point Nike Missile Site, San Pedro, California

Open-system Behavior during Pluton-Wall-rock Interaction as Constrained from a Study of Endoskarns in the Sierra Nevada Batholith, California

This report is the result of field work performed at the former White Point Nike Missile Site, San Pedro, California. The Hazardous Waste Remedial Actions Program tasked the Oak Ridge National Laboratory Pollutant Assessments Group in Grand Junction, Colo., with this project. The objective was to determine whether or not radioisotopes possibly associated with past Department of Defense (DOD) operations were present and within accepted background levels. The radiation survey was accomplished by performing three independent radiation surveys, both outdoors and indoors, and random soil sampling. Initially, the site was land surveyed to develop a grid block system. A background radiation investigation was performed out in the San Pedro area.

153

British Library Electronic Table of Contents (United Kingdom)

Crustal xenoliths (pyroxenites and plagioclase + quartz + pyroxene lithologies) from the Quaternary Big Pine volcanic field on the eastern flank of the Sierra Nevada Batholith in California (USA) represent the products of metasomatic reaction between the margins of a Cretaceous granodioritic pluton and Paleozoic marbles, possibly at mid-crustal depths based on the equilibration temperatures recorded by Ti-in-quartz geothermometry. This interpretation is based on the presence of plagioclase showing relict plutonic textures, pyroxenite characterized by nearly pure diopside clinopyroxene, recrystallized plagioclase with anomalously high anorthite content, textures indicating replacement of plagioclase by clinopyroxene (and vice versa), `ghost' plagioclase rare earth element signatures in some...

2011-01-01

154

Near term and future alternative clean vehicle technologies

Loss of genetic connectivity and diversity in urban microreserves in a southern California endemic Jerusalem cricket (Orthoptera: Stenopelmatidae: Stenopelmatus n. sp. ?santa monica??)

Availability of a natural gas-powered van that meets California`s ultra low emission vehicle requirements and has a 300-km range was reported. A similar van with an electric system giving a range of 240 km was also within sight. Regarding the limitations of electric batteries it was suggested that a super capacitor may allow systems to achieve higher energy densities; a refuelable zinc-air battery could be considered for vehicle use. While the prospect for emissions improvement of gasoline vehicles has clearly improved in recent years, the relative costs of infrastructure, vehicle and fuel for the the alternative fuels compared with gasoline demonstrate the difficulty the alternative fuels have in taking market share from gasoline. For the next decade, gasoline, propane and CNG are expected to be the dominant fuels for vehicles. After that, the leading fuel will be the one that has been most extensively researched and developed during the decade. 17 refs.

1994-12-31

155

British Library Electronic Table of Contents (United Kingdom)

Microreserves may be useful in protecting native arthropod diversity in urbanized landscapes. However, species that do not disperse through the urban matrix may eventually be lost from these fragments. Population extinctions may be precipitated by an increase in genetic differentiation among fragments and loss of genetic diversity within fragments, and these effects should become stronger with time. We analyzed population genetic structure in the dispersal limited Jerusalem cricket Stenopelmatus n. sp. ?santa monica?? in the Santa Monica Mountains and Simi Hills north of Los Angeles, California (CA), to determine the impacts of fragmentation over the past 70 years. MtDNA divergence was greater among urban fragments than within contiguous habitat and was positively correlated with fragment ...

2009-01-01

156

Field results using measurement-while-drilling directional systems in Long Beach, California

Environmental planning for geothermal energy resource exploration, development, and utilization

One of the more extensive uses of directional drilling anywhere in the world has been in the development of the East Wilmington Oil Field in Long Beach, California. The Measurement-While-Drilling (MWD) directional system has been tested on several wells and proven to provide the required accuracy, along with many advantages over past methods, used in the field development. Accurate transmission by MWD of bottom-hole measurements to the surface is provided by mud pressure pulses generated in the drill pipe downhole and detected by a pressure transducer includes the means for detecting, recording and processing these pressure pulses, to translate the information from the pressure pulses to rig floor displays usable by the drilling crew. 2 refs.

1981-01-01

157

Dynamics of photosynthetic photon flux density (PPFD) and estimates in coastal northern California

The commercialization of geothermal energy resources consists of a sequence of exploration, development, and utilization activities. Each of these activities are beset by both generic and project specific technical, environmental, and institutional constraints which must be adequately resolved before geothermal operations can be conducted. This report presents a summary of selected environmental activities conducted during the early planning stages of geothermal resource commercialization. Three representative activities are elaborated upon. These include preliminary environmental planning for geothermal energy development in the Medicine Lake Highlands of California; potential alternatives for non-electric use of the geothermal resource at East Mesa in Imperial County, California; and site specific studies of the impacts from using East Mesa geothermal fluids to irrigate selected crops and indigenous climax vegetation.

1982-01-01

158

British Library Electronic Table of Contents (United Kingdom)

Plants require solar radiation for photosynthesis and their growth is directly related to the amount received, assuming that other environmental parameters are not limiting. Therefore, precise estimation of photosynthetically active radiation (PAR) is necessary to enhance overall accuracies of plant growth models. This study aimed to explore the PAR radiant flux in the San Francisco Bay Area of northern California. During the growing season (March through August) for 2?years 2007?2008, the on-site magnitudes of photosynthetic photon flux densities (PPFD) were investigated and then processed at both the hourly and daily time scales. Combined with global solar radiation (R S) and simulated extraterrestrial solar radiation, five PAR-related values were developed, i.e., flux density-based PAR ...

2011-01-01

159

Correlation and interpretation of three-component survey seismic anomalies, Zamora gas field, northern Sacramento Valley, California

Correlation and interpretation of three-component survey seismic anomalies, Zamora Gas field, northern Sacramento Valley, California

A three-component seismic line acquired over the Zamora gas field, northern Sacramento Valley, California, displays conventional (P-P) and converted-wave (P-SV) seismic anomalies. Well log and seismic modeling results indicate that bright-spot reflection strengths are related to variations in fluid saturation and lithology. The P-SV reflection strengths and interval velocities provide valuable information that complements more conventional strategies such as amplitude with offset and polarity analysis. This integrated strategy can improve risk evaluation and well-site selection in areas where rapid changes in reservoir quality impact resource evaluation.

1989-03-01

160

Toxicity of ultraviolet-irradiated halothane in mice

A three-component seismic line acquired over the Zamora gas field, northern Sacramento Valley, California, displays conventional (P-P) and converted-wave (P-SV) seismic anomalies. Well log and seismic modeling results indicate that bright-spot reflection strengths are related to variations in fluid saturation and lithology. The converted-wave reflection strengths and interval velocities provide valuable information that compliments more conventional strategies such as amplitude with offset and polarity analysis. This integrated strategy can improve risk evaluation and well site selection in areas where rapid changes in reservoir quality impact resource evaluation.

1989-04-01

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161

Neurotoxicological effects of cinnabar (a Chinese mineral medicine, HgS) in mice

One such agent is the widely used anesthetic, halothane. To study the toxicity of u.v. decomposed halothane, mice were exposed to anesthetic concentrations (1.3%) of non- and u.v.-irradiated halothane in oxygen for 90 min. Halothane sleeping times increased from 14.3 min to 72.5 min. Microsomal mixed function oxidase activity decreased, as shown by prolonged pentobarbital sleeping times 1 day after exposure to halothane and irradiated halothane (54.6 min and 149.1 min, respectively, as compared to a 34.6-min control). Quantitative and qualitative differences were found in the amount of (/sup 14/C)-pentobarbital metabolites excreted by u.v. irradiated halothane-exposed mice compared to either oxygen or non-irradiated halothane-exposed groups. In addition, serum glutamic-oxalacetic transaminase (SGOT) of irradiated halothane-exposed mice increased to 233% of the control values, and serum glutamic-pyruvic transaminase (SGPT) ...

1982-01-01

162

Dose dependent transfer of [sup 203]lead to milk and tissue uptake in suckling offspring studied in rats and mice

Cinnabar, a naturally occurring mercuric sulfide (HgS), has long been used in combination with traditional Chinese medicine as a sedative for more than 2000 years. Up to date, its pharmacological and toxicological effects are still unclear, especially in clinical low-dose and long-term use. In this study, we attempted to elucidate the effects of cinnabar on the time course of changes in locomotor activities, pentobarbital-induced sleeping time, motor equilibrium performance and neurobiochemical activities in mice during 3- to 11-week administration at a clinical dose of 10 mg/kg/day. The results showed that cinnabar was significantly absorbed by gastrointestinal (G-I) tract and transported to brain tissues. The spontaneous locomotor activities of male mice but not female mice were preferentially suppressed. Moreover, frequencies of jump and stereotype-1 episodes were progressively decreased after 3-week oral administration ...

2007-10-15

163

The Development of 6061-Aluminum Windows for the MICE LiquidAbsorber

The dose-dependent transfer of [sup 203]Pb to milk and uptake in suckling rats and mice during a three-day nursing period was studied. On day 14 of lactation, the dams were administered a single intravenous dose of lead, labelled with [sup 203]Pb, in four or five doses from 0.0005 to 2.0 mg Pb/kg b.wt. There was a linear relationship between Pb levels in plasma and milk of both species. The Pb milk: plasma ratios at 24 hr after administration were 119 and 89 in mice and rats, respectively. At 72 hr the Pb milk: plasma ratio had decreased to 72 in mice and 35 in rats. The tissue levels of lead in the suckling rats and mice were also linearly correlated with lead concentration in milk at 72 hr, showing that milk could be used as an indicator of lead exposure to the suckling offspring. It is concluded that lead is transported into rat and mouse milk to a very high extent and the excretion into milk is more ...

1993-09-01

164

Tea catechins prevent contractile dysfunction in unloaded murine soleus muscle: A pilot study

The thin windows for the Muon Ionization Cooling Experiment (MICE) liquid Absorber will be fabricated from 6061-T6-aluminum. The absorber and vacuum vessel thin windows are 300-mm in diameter and are 180 mm thick at the center. The windows are designed for an internal burst pressure of 0.68 MPa (100 psig) when warm. The MICE experiment design calls for changeable windows on the absorber, so a bolted window design was adopted. Welded windows offer some potential advantages over bolted windows when they are on the absorber itself. This report describes the bolted window and its seal. This report also describes an alternate window that is welded directly to the absorber body. The welded window design presented permits the weld to be ground off and re-welded. This report presents a thermal FEA analysis of the window seal-weld, while the window is being welded. Finally, the results of a test of a welded-window are presented.

2005-08-24

165

British Library Electronic Table of Contents (United Kingdom)

ObjectiveExtended periods of muscle disuse, physical inactivity, immobilization, and bedrest result in a loss of muscle mass and a decrease in muscle force, which are accompanied by an increase in oxidative stress. We investigated the effects of the intake of green tea catechins on unloading-induced muscle dysfunction in tail-suspended mice. MethodsTen-week-old male BALB/c mice were fed a purified control diet or a diet containing 0.5% tea catechins for 14 d. Thereafter, the mice were subjected to continuous tail suspension for 10 d. On the final day, muscle mass, contractile force production, antioxidant potential, and carbonylated protein levels were evaluated. ResultsHind limb unloading caused a loss of soleus muscle weight and muscle force. Intake of tea catechins significantly inhibit...

2011-01-01

166

Selective vulnerability of dorsal root ganglia neurons in experimental rabies after peripheral inoculation of CVS-11 in adult mice

British Library Electronic Table of Contents (United Kingdom)

The involvement of dorsal root ganglia was studied in an in vivo model of experimental rabies virus infection using the challenge virus standard (CVS-11) strain. Dorsal root ganglia neurons infected with CVS in vitro show prolonged survival and few morphological changes, and are commonly used to study the infection. It has been established that after peripheral inoculation of mice with CVS the brain and spinal cord show relatively few neurodegenerative changes, but detailed studies of pathological changes in dorsal root ganglia have not previously been performed in this in vivo experimental model. In this study, adult ICR mice were inoculated in the right hindlimb footpad with CVS. Spinal cords and dorsal root ganglia were evaluated at serial time points for histopathological and ultrastru...

2009-01-01

167

Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice

British Library Electronic Table of Contents (United Kingdom)

Purpose PR-104, a bioreductive prodrug in clinical trial, is a phosphate ester which is rapidly metabolized to the corresponding alcohol PR-104A. This dinitrobenzamide mustard is activated by reduction to hydroxylamine (PR-104H) and amine (PR-104M) metabolites selectively in hypoxic cells, and also independently of hypoxia by aldo-keto reductase (AKR) 1C3 in some tumors. Here, we evaluate reductive metabolism of PR-104A in mice and its significance for host toxicity. Methods The pharmacokinetics of PR-104, PR-104A and its reduced metabolites were investigated in plasma and tissues of mice (with and without SiHa or H460 tumor xenografts) and effects of potential oxidoreductase inhibitors were evaluated. Results Pharmacokinetic studies identified extensive non-tumor reduction of PR-104A to t...

2011-01-01

168

Progress on the Design and Fabrication of the MICE Focusing Magnets

Melatonin exerts differential actions on X-ray radiation-induced apoptosis in normal mice splenocytes and Jurkat leukemia cells

The Muon Ionization Cooling Experiment (MICE) focusing solenoid magnets focus the muon beam within the MICE cooling channel on a liquid or solid absorber that is within the warm bore of solenoid. The focusing magnet has a warm bore of 470 mm. his magnet consists of two coils 210-mm long that is separated by an aluminum mandrel that is 200 mm long. Each of the coils has its own leads. The coils may be operated in either the non-flip mode (solenoid mode with both coils at the same polarity) or the lip mode (quadrupole focusing mode where both coils are at opposite polarity). This report describes the focusing solenoid magnet design that will be built by the vendor. The progress on the construction of the first of the focusing magnets will also be discussed in this report. Ultimately three of these magnets will be built. These magnets will be cooled using a pair 1.5 W (at 4.2 K) pulse tube coolers.

2009-10-19

169

British Library Electronic Table of Contents (United Kingdom)

Abstract: The ability of melatonin as a potent antioxidant was used as a rationale for testing its antiapoptotic ability in normal cells. Recently, melatonin was shown to possess proapoptotic action by increasing reactive oxygen species in certain cancer cells. The modification of radiation-induced apoptosis by melatonin and the expression of apoptosis-associated upstream regulators were studied in normal mice splenocytes and Jurkat T leukemia cells. C57BL/6 mice were exposed to a single whole body X-ray radiation dose of 2 Gy with or without 250 mg/kg melatonin pretreatment. The Jurkat cells were divided into four groups of control, 1 mm melatonin alone, 4 Gy irradiation-only and melatonin pretreatment before irradiation. The highest level of apoptosis in the normal splenic white pulp was...

2009-01-01

170

Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice

British Library Electronic Table of Contents (United Kingdom)

Glycyrrhizin is a triterpene glycoside, a major active constituent of licorice (Glycyrrhiza glabra) root and numerous pharmacological effects like anti-inflammatory, anti-viral, anti-tumour and hepatoprotective activities has been attributed to it. In this study we evaluated the anti-inflammatory activities of glycyrrhizin in mice model of acute inflammation, carrageenan-induced pleurisy. We report here that glycyrrhizin (given at 10mg/kg i.p. 5min prior to carrageenan) exerts potent anti-inflammatory effects in this model. Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity which contained a large number of neutrophils (PMNs) as well as an infiltration of PMNs in lung tissues and subsequ...

2008-01-01

171

Effects of dietary glucosylceramide on dermatitis in atopic dermatitis model mice

British Library Electronic Table of Contents (United Kingdom)

The effects of dietary plant and yeast cerebroside (glucosylceramide), a major sphingolipid in plants and yeast, on atopic dermatitis (AD) like symptoms were investigated in a mouse model. After 7 wk of feeding with a diet containing maize glucosylceramide, plasma IgE levels became significantly lower and in contrast, the levels of interleukin (IL)-12, which induces cellular immunity, became significantly higher in the AD mice than in the controls. However, the sphingolipid constituents of the skin fraction in the maize glucosylceramide fed group did not contain sphingoid bases of plant origin, such as 8-unsaturated sphingoid bases. The results of the present study indicated that dietary plant glucosylceramide prevented AD-like symptoms in AD model mice via regulation of Th1/Th2 balance. P...

2010-01-01

172

Effect of some chemicals on the radiation-induced lipid peroxidation

Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder - a preliminary study

The effect of exposure to gamma rays on LPO contents in liver, spleen and kidney of mice and the anti-lipid-peroxidation of preparations of chinonin, tannic acid and squalene were reported. All these preparations were given by intragastric perfusion. For LPO, a modified method of TBA spectrophotometry was used for determination. The results show that LPO contents in tissues increased 72 h after whole-body exposure of mice to gamma rays, that in range of 0-4 Gy, there was a linear relationship between radiation doses and LPO contents, and that all three preparations were effective in reduction of the LPO content in liver, spleen and kidney of mice, with chinonin (at dose of 0.35 mg/mouse#centre dot#day) being more effective than tannic acid (at dose of 15 mg/mouse#centre dot#day) and squalene (at dose of 0.6 mg/mouse#centre dot#day).

173

British Library Electronic Table of Contents (United Kingdom)

Please cite this paper as: Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder - a preliminary study. Experimental Dermatology 2008; 17: 203-207. Abstract: Pseudoxanthoma elasticum (PXE), a heritable multisystem disorder, is caused by mutations in the ABCC6 gene. We have developed a murine model for PXE by targeted inactivation of the corresponding mouse gene. A feature of this mouse model is ectopic mineralization of connective tissue capsule surrounding the bulb of vibrissae. This study was designed to investigate the effect of dietary sevelamer hydrochloride (Renagel), a phosphate binder, and specific mineral modifications on ectopic mineralization of connective tissue in Abcc6-/- mice. Three groups were fed a specific di...

2008-01-01

174

Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice

British Library Electronic Table of Contents (United Kingdom)

Fyn is a Src-family tyrosine kinase that affects long term potentiation (LTP), synapse formation, and learning and memory. Fyn is also implicated in dendritic spine formation both in vitro and in vivo. However, whether Fyn's regulation of dendritic spine formation is brain-region specific and age-dependent is unknown. In the present study, we systematically examined whether Fyn altered dendritic spine density and morphology in the cortex and hippocampus and if these effects were age-dependent. We found that Fyn knockout mice trended toward a decrease in dendritic spine density in cortical layers II/III, but not in the hippocampus, at 1month of age. Additionally, Fyn knockout mice had significantly decreased dendritic spine density in both the cortex and hippocampus at 3months and 1year, an...

2011-01-01

175

Computational mouse atlases and their application to automatic assessment of craniofacial dysmorphology caused by the Crouzon mutation Fgfr2C342Y

British Library Electronic Table of Contents (United Kingdom)

Abstract Crouzon syndrome is characterized by premature fusion of sutures and synchondroses. Recently, the first mouse model of the syndrome was generated, having the mutation Cys342Tyr in Fgfr2c, equivalent to the most common human Crouzon/Pfeiffer syndrome mutation. In this study, a set of micro-computed tomography (CT) scannings of the skulls of wild-type mice and Crouzon mice were analysed with respect to the dysmorphology caused by Crouzon syndrome. A computational craniofacial atlas was built automatically from the set of wild-type mouse micro-CT volumes using (1) affine and (2) non-rigid image registration. Subsequently, the atlas was deformed to match each subject from the two groups of mice. The accuracy of these registrations was measured by a comparison of manually placed landma...

2007-01-01

176

A study of the distribution of schistosomicidal drug H-3-7505 in mice

Tehachapi solar thermal system first annual report

The authors have studied the distribution of H-3 labelled schistosomicidal drug in mice by autoradiography. The H-3-labelled substances were found in liver and kidney and in successfully decreasing amounts in brain, lung, heart, fat, testis, pancreas and spleen. In various cells the silver granules were present mainly in the cytoplasms but a few in the nucleus. After administration of this labelled schistosomicidal drug, the mice were killed and studied in groups successively at 4, 8, 24 hrs. No difference in the distribution of silver granules were observed. This fact indicated that, this drug was rapidly absorbed and highly concentrated with a long duration of reservation in liver. All of these favours the schistosomicidal effect of the drug. As this drug was highly concentrated in the cytoplasm of liver cells, that might provide a pathophysiologic basis for the explanation of jaundice in the clinical practice. Moreover, the appearance of ...

1985-05-01

177

Recent plate motions and crustal deformation

The staff of the Southwest Technology Development Institute (SWTDI), in conjunction with the staff of Industrial Solar Technology (IST), have analyzed the performance, operation, and maintenance of a large solar process heat system in use at the 5,000 inmate California Correctional Institution (CCI) in Tehachapi, CA. This report summarizes the key design features of the solar plant, its construction and maintenance histories through the end of 1991, and the performance data collected at the plant by a dedicated on-site data acquisition system (DAS).

1993-05-01

178

Phytoremediation of Selenium Contaminated Soil, and Water Produces Biofortified Products and New Agricultural Byproducts

Reports by U.S. workers on geodetic measurements of recent plate motions or crustal deformation published in 1987-1990 are reviewed. The review begins with global plate motions, proceeds through plate boundaries in California, Alaska, and the Pacific Northwest, and finishes with volcanic phenomena, monument stability and longevity, and GPS relative position measurements. 184 refs.

1991-01-01

179

Modern carbonate sediments and environments of the LaPaz region, Baja California Sur, Mexico

Based upon these processes-phytoextraction, phytovolatization and phytostabilization-a plant management remediation strategy for selenium (Se) has been developed for the Westside of Central California. Multi-year field phytoremediation studies were conducted between 2002-2007 on Se-tainted field si...

180

Forum: Science and Innovation for Sustainable Development - Framework

The Gulf of California represents one of the most productive and unique marginal seas in the world. The mouth of the Gulf captures warm equatorial water while annual wind patterns assure major upwelling of nutrient-rich water leading to a rich marine biota. These conditions have created a wide array of tropical through warm temperate carbonate environments. The most unusual of these environments is located in the La Paz region of Baja California Sur where tropical-subtropical water temperatures and low rainfall have allowed growth of corals, calcareous red algae, and other shelled invertebrates to form a carbonate bank environment. Sampling and mapping transacts in shallow bays north of La Paz and on the adjacent Espiritu Santo island have revealed a full spectrum of subenvironments including mangrove bordered, terrigenous mud dominated coastal zones, which grade into carbonate tidal flats. In addition, single coral heads as well as incipient ...

1996-12-31

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181

Wastenet

... Studies People Projects Opportunities Framework Critical Sectors Development Goals Geographic Region Geographic Scale Research Themes Printer-Friendly Center for Ocean Solutions Early Career Fellowship Program Location: Stanford, California Source: The Center for Ocean Solutions (Ocean Solutions) seeks one or more recent graduates who have received a JD, MBA or PhD in the natural, physical or social sciences in the last five years, and who ...

182

Flexible DER Utility Interface System: Final Report, September 2004--May 2006

Field Investigation of a Wake Structure Downwind of a VAWT (Vertical-Axis Wind Turbine) in a Wind Farm Array.

In an effort to accelerate deployment of Distributed Energy Resources (DER) such as wind, solar, and conventional backup generators to our nation's electrical grid, Northern Power Systems (NPS), the California Energy Commission (CEC), and the National Renewable Energy Laboratory (NREL) collaborated to create a prototype universal interconnect device called the DER Switch.

2006-08-01

183

Experience with a digital noise analysis system in subcriticality measurements on a mockup of the FFTF

The effects of upwind turbine wakes on the performance of a FloWind 17-m vertical-axis wind turbine (VAWT) were investigated through a series of field experiments conducted at the FloWind wind farm on Cameron Ridge, Tehachapi, California. From the field m...

1988-01-01

184

Direct application of West Coast geothermal resources in a wet-corn-milling plant. Final report

From nuclear science symposium; San Francisco, California, USA (14 Nov 1973). A digital Fourier analyzer was programmed to perform reactor neutron noise analysis measurements and on-line processing of the data to obtain the steady-state reactivity. The system is suitable for recovering cross spectral density with low correlatedsignal component and for repetitive measurements with efficient use of reactor time. (auth)

1973-01-01

185

Coastal conservation: essays on experiments in governance. [Monograph

The engineering and economic feasibility of using the geothermal resources in East Mesa, California, in a new corn processing plant is evaluated. Institutional barriers were also identified and evaluated. Several alternative plant designs which used geothermal energy were developed. A capital cost estimate and rate of return type of economic analysis were performed to evaluate each alternative. (MHR)

1981-03-01

186

Beyond "Little Taipei": The Development of Taiwanese Immigrant Businesses in Los Angeles.

Three book reviews and five essays address the problems of governing coastal regions. The books reviewed and the articles covered the institutions and programs involved in resource management, the balance of local and state interests in coastal conservation and developments, a consensus on coastal planning issues, and a growing trend in state-local collaborative planning. Four of the articles pertain to California, and one focuses on programs in Maine, Rhode Island, and Washington. 135 references. (DCK)

1981-01-01

187

BP Industrial Synergies Opportunities Investigation (3B6)

Qualitative and quantitative techniques, including a telephone survey of 310 Taiwanese business owners, were used to study the unique features of Taiwanese immigrant businesses in Los Angeles (California). When provided with entrepreneurial capital, Taiwanese enterprises grow rapidly in the context of Los Angeles's economic restructuring. (SLD)

1994-12-01

188

Wastenet

... However, Hydrogen Energy is working towards establishing hydrogen-fired power generation facilities in other parts of the world (e.g. California, Abu Dhabi and elsewhere) and the synergies work carried out for the Kwinana proposal would provide a good starting basis for other proposals. ...

189

All wired up and ready to go

Advanced Lighting Program Development (BG9702800) Final Report

Electric cars have long been seen as science fiction. This may be changing. As the 1990s began, several companies chose to launch publicity campaigns for electric vehicles. In California, experimental programmes are gaining momentum, in the context of LA's appalling air pollution problems and tightening clean air standards. Supporters claim that electric motive power is a key to solving several environmental problems involving atmospheric pollution. These claims are examined. (author).

1990-01-01

190

Addressing transportation energy and environmental impacts: technical and policy research directions

The report presents a long-range plan for a broad-based, coordinated research, development and market transformation program for reducing the lighting energy intensities in commercial and residential buildings in California without compromising lighting quality. An effective program to advance lighting energy efficiency in California must be based on an understanding that lighting is a mature field and the lighting industry has developed many specialized products that meet a wide variety of light needs for different building types. Above all else, the lighting field is diverse and there are applications for a wide range of lighting products, systems, and strategies. Given the range of existing lighting solutions, an effective energy efficient lighting research portfolio must be broad-based and diverse to match the diversity of the lighting market itself. The belief that there is one solution--a magic bullet, such as a better lamp, for ...

1998-02-01

191

A summary of the California Public Utilities Commission`s two competing electric utility restructuring proposals

The Lawrence Livermore National Laboratory (LLNL) is establishing a local chapter of the University of California Energy Institute (UCEI). In order to most effectively contribute to the Institute, LLNL sponsored a workshop on energy and environmental issues in transportation. This workshop took place in Livermore on August 10 and brought together researchers from throughout the UC systems in order to establish a joint LLNL-UC research program in transportation, with a focus on energy and environmental impacts.

1995-08-01

192

60 million dollars for electric cars; 60 Millionen Dollar fuer die Formel-EE

In May 1995, the California Public Utilities Commission (CPUC) released two proposals for restructuring the state`s electric power industry. The two proposals follow more than a year of testimony and public comment after the CPUC issued the ``Blue Book`` (CPUC 1994a) on April 20, 1994, which called for retail wheeling to be phased in to all customers over 5 years. The majority proposal, supported by three of the four CPUC commissioners (one seat was vacant when the proposals were released), calls for creating a central pool, or ``poolco``; setting electric prices to reflect true costs of service, or ``real-time pricing``; and allowing parties to negotiate ``contracts for differences`` between the pool price and the contract price. The minority proposal, sponsored by Commissioner Jesse Knight, calls for retail wheeling, or ``direct access,`` and for utilities to divest or spin off their generating assets. This paper presents a summary of the major provisions of the ...

1995-11-01

193

Softwood forest thinning as a biomass source for ethanol production: A feasibility study for California

Rising oil prices are a problem for the motor car industry. Now, an ambitious project has been launched in California which may become a serious competitor to gasoline and diesel engines: The Tesla Roadster, which is fuelled from simple wall sockets. (orig.)

2007-07-01

194

MENTOR-BASED EFFORT TO ADVANCE IMPLEMENTATION OF PREFERRED MANAGEMENT PRACTICES (PMPS) FOR OIL PRODUCERS IN SOUTH MIDCONTINENT (OKLAHOMA/ARKANSAS) AND WEST COAST (CALIFORNIA) REGIONS

A plan has been put forth to strategically thin northern California forests to reduce fire danger and improve forest health. The resulting biomass residue, instead of being open burned, can be converted into ethanol that can be used as a fuel oxygenate or an octane enhancer. Economic potential for a biomass-to-ethanol facility using this softwood biomass was evaluated for two cases: Stand-alone and co-located. The co-located case refers to a specific site with an existing biomass power facility owned by Wheelabrator Environmental Systems Inc. near Martell, California. A two-stage dilute acid hydrolysis process is used for the production of ethanol from softwoods, and the residual lignin is used to generate steam and electricity. For a plant processing 800 dry tonnes per day of feedstock, the co-located case is an economically attractive concept. Total estimated capital investment is approximately $ 70 million for the co-located case. The ...

2000-07-01

195

piggyBac Transposon-mediated Long-term Gene Expression in Mice

The Petroleum Technology Transfer Council (PTTC) and cooperating Regional Lead Organizations (RLOs) in its South Midcontinent (Oklahoma Geological Survey, Norman, Oklahoma) and West Coast (University of Southern California, Los Angeles, California) regions conducted a ''Mentor-Based Effort to Advance Implementation of Preferred Management Practices (PMPs) For Oil Producers'' (DE-FC26-01BC15272) under an award in Phase I of Department of Energy's (DOE's) PUMP (Preferred Upstream Management Practices) program. The project's objective was to enable producers in California, Oklahoma and Arkansas to increase oil production, moderating or potentially reversing production declines and extending the life of marginal wells in the near term. PTTC identified the primary constraints inhibiting oil production through surveys and PUMPer direct contacts in both regions. The ...

2004-12-01

196

Wild-derived mouse stocks: an underappreciated tool for aging research

Transposons are promising systems for somatic gene integration because they can not only integrate exogenous genes efficiently, but also be delivered to a variety of organs using a range of transfection...Full Text Available

2010-04-01

197

Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice

Virtually all biomedical research makes use of a relatively small pool of laboratory-adapted, inbred, isogenic stocks of mice. Although the advantages of these models are many, there are a number of...Full Text Available

2008-09-01

198

Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans

Exercise promotes weight loss and improves insulin sensitivity. However, the molecular mechanisms mediating its beneficial effects are not fully understood. Obesity correlates with increased production...Full Text Available

2008-09-01

199

Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice

Bloodstream infection by highly antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a growing clinical problem that increasingly defies medical intervention....Full Text Available

2010-12-01

200

Transplantation of allogeneic T cells alters iron homeostasis in NOD/SCID mice

BackgroundThe dynorphin-kappa opioid receptor (KOR) system regulates glial proliferation after sciatic nerve injury. Here, we investigated its role in cell proliferation following...Full Text Available

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201

Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure

Iron overload is common in patients undergoing allogeneic hematopoietic cell transplantation (HCT), but the mechanisms leading to overload are unknown. Here, we determined iron levels and the expression...Full Text Available

2009-02-19

202

Tissue oxygenation in a murine SCC VII tumor after X-ray irradiation as determined by EPR spectroscopy

BackgroundIsoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease. In this study, we compared the transcriptional response...Full Text Available

203

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

PurposeThe goal of this study was to clarify the dynamics of tumor oxygen (partial pressure of oxygen, pO₂) in SCC VII murine tumors in mice after X-ray...Full Text Available

2008-03-01

204

The effects of thiamin on lead metabolism: organ distribution of lead 203.

Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen...Full Text Available

2009-12-01

205

The Zinc Finger SET Domain Gene Prdm14 Is Overexpressed in Lymphoblastic Lymphomas with Retroviral Insertions at Evi32

The effect of thiamin on the organ distribution of lead was evaluated in CD-1 mice exposed intragastrically or intraperitoneally to a single dose of lead acetate (100 micrograms) containing 100 microCi...Full Text Available

1992-07-01

206

Studies on the mechanism of 1,3-butadiene-induced leukemogenesis: the potential role of endogenous murine leukemia virus.

BackgroundAKXD recombinant inbred strains of mice have proven to be very useful in the identification of potential oncogenes and tumor suppressors involved in the development of...Full Text Available

207

Stem cell kinetics in spleen and bone marrow after single and fractionated irradiation of infant mice

Previous studies have revealed marked differences in the incidence of leukemia between rats and mice exposed to 1,3-butadiene that do not appear to be readily explained on the basis of pharmacokinetics...Full Text Available

1990-06-01

208

Stem Cell Therapies Benefit Alport Syndrome

The number and type of stem cells in spleen and bone marrow of mice were determined after exposure to a single dose of 150 R on day 6, to a single dose of 500 R on day 6 or day 9 or to a fractionated dose of 150 R + 350 R on day 6 and 9. The stem cells were assayed on the basis of colony forming units (CFU) in spleen and of incorporation of iododeoxyuridine in spleen and bone marrow of lethally irradiated host mice. During the first month of life, the number of stem cells in non-irradiated mice increases markedly in bone marrow and slightly in spleen. Irradiation causes a long-lasting depression in stem cells, particularly in bone marrow and affecting preferentially erythropoietic precursor cells. Following a dose of only 150 R, the number of CFU in bone marrow is still below control levels 24 days later. An exposure to 500 R fractionated between day 6 and 9 has a markedly greater effect on stem cells in the spleen than the ...

1980-12-01

209

Specific genetic modifications of domestic animals by gene targeting and animal cloning

Patients with Alport syndrome progressively lose renal function as a result of defective type IV collagen in their glomerular basement membrane. In mice lacking the α3 chain of type IV collagen...Full Text Available

2009-11-01

210

Simple Behavioral Assessment of Mouse Olfaction

The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large...Full Text Available

211

Sex modifies exercise and cardiac adaptation in mice

This unit presents two basic protocols that offer rapid assessments of anosmia (the absence of a sense of smell) in mice. The buried food test is used to check for the ability to smell volatile...Full Text Available

2009-07-01

212

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor kB and Forkhead Box O Phosphorylation

How an individual’s sex and genetic background modify cardiac adaptation to increased workload is a topic of great interest. We systematically evaluated morphological and physiological...Full Text Available

2004-12-01

213

British Library Electronic Table of Contents (United Kingdom)

We hypothesized that I kappa B kinase (IKK)-mediated nuclear factor kappa B and forkhead BoxO3a phosphorylation will be associated with age-related endothelial dysfunction. Endothelium-dependent dilation and aortic protein expression/phosphorylation were determined in young and old male B6D2F1 mice and old mice treated with the IKK inhibitor, salicylate. IKK activation was greater in old mice and was associated with greater nitrotyrosine and cytokines. Endothelium-dependent dilation, nitric oxide (NO), and endothelial NO synthase phosphorylation were lower in old mice. Endothelium-dependent dilation and NO bioavailability were restored by a superoxide dismutase mimetic. Nuclear factor kappa B and forkhead BoxO3a phosphorylation were greater in old and were associated with increased express...

2011-01-01

214

Role of interferon-gamma in interleukin 12-induced pathology in mice.

Risedronate Prevents Early Radiation-Induced Osteoporosis in Mice at Multiple Skeletal Locations

Interleukin 12 (IL-12) activates natural killer (NK) and T cells with the secondary synthesis and release of interferon-gamma (IFN-gamma) and other cytokines. IL-12-induced organ alterations are reported...Full Text Available

1995-12-01

215

Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging?

IntroductionIrradiation of normal, non-malignant bone during cancer therapy can lead to atrophy and increased risk of fracture at several skeletal sites, particularly...Full Text Available

2010-01-01

216

Regulation of apoptosis by the circadian clock through NF-?B signaling

We have recently reported that progeroid Zmpste24^−/− mice, which exhibit multiple defects that phenocopy Hutchinson-Gilford progeria syndrome, show a profound dysregulation...Full Text Available

217

Rearrangement of Retinogeniculate Projection Patterns after Eye-Specific Segregation in Mice

In mice and humans the circadian rhythm of many biochemical reactions, physiology, and behavior is generated by a transcriptional-translation feedback loop (TTFL) made up of the so-called core clock...Full Text Available

2011-07-19

218

RasGrf1 deficiency delays aging in mice

It has been of interest whether and when the rearrangement of neuronal circuits can be induced after projection patterns are formed during development. Earlier studies using cats reported that the rearrangement...Full Text Available

219

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

RasGRF1 is a Ras-guanine nucleotide exchange factor implicated in a variety of physiological processes including learning and memory and glucose homeostasis. To determine the role of RASGRF1 in aging,...Full Text Available

220

QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains

Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight gain; however, the...Full Text Available

2011-04-01

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221

Proteomic approach with LCMS-IT-TOF identified an increase of Rab33B after transient focal cerebral ischemia in mice

The activity of mice in their home cage is influenced greatly by the cycle of light and dark. In addition, home-cage activity shows remarkable time-dependent changes that result in a prominent temporal...Full Text Available

2010-10-01

222

Probiotic Lactobacillus spp. Diminish Helicobacter hepaticus-Induced Inflammatory Bowel Disease in Interleukin-10-Deficient Mice

BackgroundSeveral proteins are known to be markedly expressed in the brain during cerebral ischemia; however, the changes in protein profiles within the ischemic brain after an ischemic...Full Text Available

223

Pretreatment with the gram-positive bacterial cell wall molecule peptidoglycan improves bacterial clearance and decreases inflammation and mortality in mice challenged with Pseudomonas aeruginosa

Clinical and experimental evidence has demonstrated the potential role of probiotics in the prevention or treatment of inflammatory bowel disease. Probiotic clones with direct immunomodulatory activity...Full Text Available

2005-02-01

224

Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice

The objective of this study was to determine if inflammatory tolerance and enhancement of innate immune function could be induced by the gram-positive cell wall component peptidoglycan (PGN)....Full Text Available

2008-10-01

225

Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice

Insulin resistance plays a central role in type 2 diabetes and obesity, which develop as a consequence of genetic and environmental factors. Dietary changes including high fat diet (HFD) feeding promotes...Full Text Available

226

Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation

OBJECTIVENicotinamide adenine dinucleotides (NAD⁺ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD⁺-to-NADH ratio is implicated...Full Text Available

2009-04-01

227

Parent-of-origin effects on voluntary exercise levels and body composition in mice

Allergic asthma is characterized by airway hyperresponsiveness, inflammation, and a cellular infiltrate dominated by eosinophils. Numerous epidemiological studies have related the exacerbation of allergic...Full Text Available

2011-03-01

228

PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah^enu2 mice

Despite the health-related benefits of exercise, many people do not engage in enough activity to realize the rewards, and little is known regarding the genetic or environmental components that account...Full Text Available

2010-01-01

229

PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts

Phenylketonuria (PKU) is a common genetic disorder in humans that arises from deficient activity of phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine....Full Text Available

2007-01-05

230

OLFACTORY CUES ARE SUFFICIENT TO ELICIT SOCIAL APPROACH BEHAVIORS BUT NOT SOCIAL TRANSMISSION OF FOOD PREFERENCE IN C57BL/6J MICE

The ability to achieve tumor selective expression of therapeutic genes is an area that needs improvement for cancer gene therapy to be successful. One approach to address this is through the...Full Text Available

2009-02-01

231

Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia

Mouse models for the study of autistic-like behaviors are increasingly needed to test hypotheses about the causes of autism, and to evaluate potential treatments. Both the automated 3-chambered...Full Text Available

2008-11-21

232

Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice

Increased oxidative stress is associated with perinatal asphyxia and respiratory distress in the newborn period. Induction of nuclear factor erythroid 2 p45-related factor (Nrf2) has been shown to decrease...Full Text Available

2009-04-01

233

Neoplastic transformation of prostatic and urogenital epithelium by the polyoma virus middle T gene.

OBJECTIVE—Identification of arterial genes and pathways altered in obesity and diabetes.RESEARCH DESIGN AND METHODS—Aortic gene expression profiles of...Full Text Available

2008-10-01

234

Naturally occurring double-stranded RNA and immune responses. III. Immunogenicity and antigenicity in animals.

Male transgenic mice expressing the polyomavirus middle T (PyV-MT) gene exhibited growth and developmental abnormalities in prostatic and other urogenital epithelium. Expression of PyV-MT was directed...Full Text Available

1996-10-01

235

Naturally occurring double-stranded RNA and immune responses. Effects on plaque-forming cells and antibody formation.

Naturally occurring, double-stranded RNA (ds-RNA)) was immunogenic when injected into mice, rats, guinea-pigs, rabbits, dogs and baboons. The response to native material administered intravenously (i.v.)...Full Text Available

1975-12-01

236

Murine respiratory mycoplasmosis (MRM) in C57BL/6N and C3H/HeN mice: strain differences in early host responses and exacerbation by nitrogen dioxide

A highly purified preparation of double-stranded RNA, obtained from virus-like particles in Penicillium cultures, was found to affert humoral immune responses in mice differentially depending on its...Full Text Available

1975-03-01

237

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle

The studies reported here used genetic differences in susceptibility of C57BL/6N and C3H/HeN mice and exacerbation of the disease by nitrogen dioxide (NO/sub 2/) as tools in assessing the role of early host responses in the pathogenesis of MRM. The two strains did not differ in susceptibility to infection, but C3H/HeN mice were more susceptible to and had increased severity of lung lesions 14 days after intranasal inoculation as determined by 50% biological endpoints and morphometric analysis of tissues. Exposure to NO/sub 2/ for 4 hours prior to exposure to infectious aerosols exacerbated murine respiratory mycoplasmosis (MRM) by 7 days after exposure in both mouse strains. NO/sub 2/ appeared to affect host lung defense mechanisms responsible for limiting mycoplasmal growth in the lungs. The NO/sub 2/ exposure concentration required for this effect varied with the genetic background of the host, the dose of mycoplasmas administered, and the ...

1987-01-01

238

Metastasis-Inducing S100A4 and RANTES Cooperate in Promoting Tumor Progression in Mice

Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders characterized by progressive muscle wasting and often premature death. The primary defect common to most MDs involves disruption...Full Text Available

2011-03-01

239

Macrophage induction of T-suppressor cells in pesticide-exposed and protozoan-infected mice.

BackgroundThe tumor microenvironment has been described as a critical milieu determining tumor growth and metastases. A pivotal role of metastasis-inducing S100A4 in the development...Full Text Available

240

Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage Fc?RI, Fc?RIII, and Fc?RIV

The use of infectious pathogens has allowed the detection of the development of synergism between pathogens and ubiquitous environmental chemical contaminants. This synergism has been demonstrated to...Full Text Available

1982-02-01

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241

Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice

Despite the demonstrated clinical efficacy of CD20 monoclonal antibody (mAb) for lymphoma therapy, the in vivo mechanisms of tumor depletion remain controversial and variable. To identify the molecular...Full Text Available

2008-08-15

242

Lnk constrains myeloproliferative diseases in mice

Retinal degenerative diseases, such as retinitis pigmentosa and Leber congenital amaurosis, are a leading cause of untreatable blindness with substantive impact on the quality of life of affected individuals...Full Text Available

2010-08-31

243

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

Hematopoietic stem and progenitor cell (HSPC) expansion is regulated by intrinsic signaling pathways activated by cytokines. The intracellular kinase JAK2 plays an essential role in cytokine signaling,...Full Text Available

2010-06-01

244

Leptin Resistance Protects Mice from Hyperoxia-induced Acute Lung Injury

Recently, genome-wide association studies (GWAS) have linked the human LIN28B locus to height and timing of menarche [1-Full Text Available

2010-07-01

245

Interaction effects of ethanol and pyrazole in laboratory rodents

Rationale: Human data suggest that the incidence of acute lung injury is reduced in patients with type II diabetes mellitus. However, the mechanisms by which diabetes confers protection...Full Text Available

2007-03-15

246

Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy

1. Interactions of pyrazole and ethanol were studied in three laboratory test procedures. They included sleeping time in mice, rotor rod balance in rats and lever pressing behaviour of rats. 2....Full Text Available

1971-09-01

247

Inhalation toxicity of vinyl chloride and Vinylidene chloride*

The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with...Full Text Available

2008-11-01

248

Influence of murine leukemia proviral integrations on development of N-methyl-N-nitrosourea-induced thymic lymphomas in AKR mice.

Exposure of mice to 1000 ppm of vinyl chloride (VC), 6 hr/day, 5 days/week, caused some acute deaths with toxic hepatitis and marked tubular necrosis of the renal cortex. Starting the sixth month,...Full Text Available

1977-12-01

249

Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice

The AKR mouse strain is characterized by a high incidence of spontaneous thymic lymphoma that appears in older animals (greater than 6 months of age) and is associated with novel provirus integrations...Full Text Available

1991-11-01

250

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

Hyperproliferation of the colonic epithelium, leading to expansion of colonic crypt progenitors, is a recognized risk factor for colorectal cancer. Overexpression of progastrin, a nonamidated and incompletely...Full Text Available

2009-09-01

251

Identification of trkH, Encoding a Potassium Uptake Protein Required for Francisella tularensis Systemic Dissemination in Mice

Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level. Metformin increases lifespan and prevents cancer...Full Text Available

252

Identification of a distant cis-regulatory element controlling pharyngeal arch-specific expression of zebrafish gdf6a/radar

Francisella tularensis is a highly infectious bacterium causing the zoonotic disease tularaemia. During its infectious cycle, F. tularensis is not only exposed to the...Full Text Available

253

Hypertrophy and Heart Failure in Mice Overexpressing the Cardiac Sodium-Calcium Exchanger

Skeletal formation is an essential and intricately regulated part of vertebrate development. Humans and mice deficient in Growth and Differentiation Factor 6 (Gdf6) have numerous...Full Text Available

2010-04-01

254

Hepatotoxicity of High Oral Dose (-)-Epigallocatechin-3-Gallate in Mice

Background:The cardiac sodium–calcium exchanger (NCX1) is a key sarcolemmal protein for the maintenance of calcium homeostasis in the heart. Since heart failure...Full Text Available

2007-05-01

255

Germ cell sex determination in mammals

The tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been studied for chronic disease preventive effects, and is marketed as part of many dietary supplements. However, case reports have...Full Text Available

2010-01-01

256

Genetic relationship between anxiety- and fear -related behaviors in BXD recombinant inbred mice

One of the major decisions that germ cells make during their development is whether to differentiate into oocytes or sperm. In mice, the germ cells’ decision to develop as male or female depends...Full Text Available

2009-04-01

257

Genetic architecture of voluntary exercise in an advanced intercross line of mice

Mood and anxiety disorders and rodent phenotypic measures modeling these disorders have a strong genetic component. Various assays are used to study the neurobiological basis of fear- and anxiety-related...Full Text Available

2009-03-01

258

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations and effects...Full Text Available

2010-07-01

259

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1?

Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations,...Full Text Available

2010-03-01

260

Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice

Keap1 regulates Nrf2 activity in response to xenobiotic and oxidative stresses. Nrf2 is an essential regulator of cytoprotective genes. Keap1-null mice are lethal by weaning age due...Full Text Available

2010-06-01

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261

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

Cigarette smoke (CS) induces recruitment of inflammatory cells in the lungs leading to the generation of reactive oxygen species (ROS), which are involved in lung inflammation and injury. Nicotinamide...Full Text Available

2008-05-01

262

Functional and morphological effects of laser-induced ocular hypertension in retinas of adult albino Swiss mice

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It is possible that the life-prolonging effects...Full Text Available

263

Functional Analysis of Neurovascular Adaptations to Exercise in the Dentate Gyrus of Young Adult Mice Associated With Cognitive Gain

PurposeTo investigate the effects of laser photocoagulation (LP)-induced ocular hypertension (OHT) on the survival and retrograde axonal transport of retinal ganglion cells (RGC),...Full Text Available

264

Fibroblast cell population kinetics in the mouse molar periodontal ligament and tooth eruption.

The discovery that aerobic exercise increases adult hippocampal neurogenesis and can enhance cognitive performance holds promise as a model for regenerative medicine. This study adds two new...Full Text Available

2009-10-01

265

Fabp7 Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype

Fibroblast cell population kinetics in the developing molar periodontal ligament was investigated in 10, 12, 16 and 20 days old mice by autoradiography after the administration of [3H]thymidine. Labelled...Full Text Available

1981-09-01

266

Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice

Deficits in prepulse inhibition (PPI) are a biological marker for schizophrenia. To unravel the mechanisms that control PPI, we performed quantitative trait loci (QTL) analysis on 1,010 F2 mice derived...Full Text Available

2007-11-01

267

Endogenous expression of Hras^G12V induces developmental defects and neoplasms with copy number imbalances of the oncogene

The destiny of the mitotically active cells of the subventricular zone (SVZ) in adult rodents is to migrate to the olfactory bulb, where they contribute to the replacement of granular and periglomerular...Full Text Available

2002-10-01

268

Emulsified Nanoparticles Containing Inactivated Influenza Virus and CpG Oligodeoxynucleotides Critically Influences the Host Immune Responses in Mice

We developed mice with germline endogenous expression of oncogenic Hras to study effects on development and mechanisms of tumor initiation. They had high perinatal mortality, abnormal...Full Text Available

2009-05-12

269

Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

BackgroundAntigen sparing and cross-protective immunity are regarded as crucial in pandemic influenza vaccine development. Both targets can be achieved by adjuvantation strategy...Full Text Available

270

Effects of Human Adipose-derived Stem Cells on Cutaneous Wound Healing in Nude Mice

Both deficiency and excess of growth hormone (GH) are associated with increased mortality and morbidity. GH replacement in otherwise healthy subjects leads to complications, whereas individuals with...Full Text Available

2010-12-21

271

Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin

BackgroundDespite numerous treatments available for deteriorated cutaneous wound healing such as a diabetic foot, there is still the need for more effective therapy. Adipose-derived...Full Text Available

2011-05-01

272

Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice

Mice lacking acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), an enzyme that catalyzes the terminal step in triacylglycerol synthesis, have enhanced insulin sensitivity and are protected from...Full Text Available

2006-08-01

273

Effect of Chloroquine on the Toxicity in Mice of the Venom and Neurotoxins from the Snake Bungarus multicinctus,

Chemoprevention strategies to prevent the development of lung cancer in at-risk individuals are a key component in disease management. In addition to being highly effective, an ideal chemopreventive...Full Text Available

2008-08-01

274

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

Antivenoms are the currently available agents for treatment of snake venom intoxication in humans. The development of therapeutic strategies employing more generally available drugs could improve treatment of invenomation by reducing hypersensitive reacti...

1987-01-01

275

Distribution of lead in lactating mice and suckling offspring with special emphasis on the mammary gland

In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia. Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is mediated by the reduced...Full Text Available

2011-10-03

276

Distribution of lead in lactating mice and suckling offspring with special emphasis on the mammary gland

The distribution of lead in lactating mice and suckling offspring was studied with whole body autoradiography at 4 and 24 h after a single intravenous injection of {sup 203}Pb (50 mmol Pb/kg) to the dams. In the lactating mice on day 14 of lactation, the highest uptake of radioactivity at 4 h after administration was recorded in renal cortex, skeleton and liver. A high uptake was also evident in the mannary gland. At 24 h after administration, the radioactivity had decreased in most organs except in the skeleton. In the suckling pups, exposed to lead only via dams` milk for 24 h, the highest level of radioactivity was present in the intestinal mucosa and a much lower level of radioactivity was present in the skeleton. The mammary glands from mice given three daily intravenous injections of 240 {mu}mol Pb/kg were examined with X-ray microanalysis. At 4 h after the last injection, lead was found associated with casein ...

1996-01-01

277

Differential effects of the mottled yellow and pseudoagouti phenotypes on immunocompetence in Avy/a mice.

The distribution of lead in lactating mice and suckling offspring was studied with whole body autoradiography at 4 and 24 h after a single intravenous injection of "2"0"3Pb (50 mmol Pb/kg) to the dams. In the lactating mice on day 14 of lactation, the highest uptake of radioactivity at 4 h after administration was recorded in renal cortex, skeleton and liver. A high uptake was also evident in the mannary gland. At 24 h after administration, the radioactivity had decreased in most organs except in the skeleton. In the suckling pups, exposed to lead only via dams' milk for 24 h, the highest level of radioactivity was present in the intestinal mucosa and a much lower level of radioactivity was present in the skeleton. The mammary glands from mice given three daily intravenous injections of 240 #mu#mol Pb/kg were examined with X-ray microanalysis. At 4 h after the last injection, lead was found associated with casein micelles ...

278

Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice

Whereas genetic factors are known to influence both susceptibility to carcinogens and the capacity to respond to specific antigenic stimuli, little is known regarding the influence of phenotype per...Full Text Available

1984-04-01

279

Development and Application of Pathovar-Specific Monoclonal Antibodies That Recognize the Lipopolysaccharide O Antigen and the Type IV Fimbriae of Xanthomonas hyacinthi

Uncoupling protein 2 (UCP2) maps to a region on distal mouse chromosome 7 that has been linked to the phenotypes of obesity and type II diabetes. We recently reported that UCP2 expression is increased...Full Text Available

1998-03-31

280

Detection and Analysis of Tumor Fluorescence Using a Two-Photon Optical Fiber Probe

The objective of this study was to develop a specific immunological diagnostic assay for yellow disease in hyacinths, using monoclonal antibodies (MAbs). Mice were immunized with a crude cell wall preparation...Full Text Available

1999-09-01

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281

Dengue Fever in Humanized NOD/SCID Mice

The utility of a two-photon optical fiber fluorescence probe (TPOFF) for sensing and quantifying tumor fluorescent signals was tested in vivo. Xenograft tumors were developed in athymic mice using MCA207...Full Text Available

2004-06-01

282

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

The increased transmission and geographic spread of dengue fever (DF) and its more severe presentation, dengue hemorrhagic fever (DHF), make it the most important mosquito-borne viral disease of humans...Full Text Available

2005-11-01

283

Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance

Circadian clock is implicated in the regulation of aging. The transcription factor CLOCK, a core component of the circadian system, operates in complex with another circadian clock protein BMAL1. Recently...Full Text Available

284

Cyst Formation in Kidney via B-Raf Signaling in the PKD2 Transgenic Mice*

OBJECTIVEPhosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions...Full Text Available

2010-04-01

285

Continuous and Periodic Expansion of CAG Repeats in Huntington's Disease R6/1 Mice

The pathogenic mechanisms of human autosomal dominant polycystic kidney disease (ADPKD) have been well known to include the mutational inactivation of PKD2. Although haploinsufficiency...Full Text Available

2009-03-13

286

Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice

Huntington's disease (HD) is one of several neurodegenerative disorders caused by expansion of CAG repeats in a coding gene. Somatic CAG expansion rates in HD vary between organs, and the greatest instability...Full Text Available

2010-12-01

287

Comparison of geographical strains of Schistosoma mansoni in the mouse*

ATP-binding cassette A3 (ABCA3) is a lipid transport protein required for synthesis and storage of pulmonary surfactant in type II cells in the alveoli. Abca3 was conditionally deleted...Full Text Available

2010-05-01

288

Chromosome X modulates incidence of testicular germ cell tumors in Ter mice

Mice were killed 7, 11, 19, and 27 weeks after infection with strains of Schistosoma mansoni from Puerto Rico, Brazil, St Lucia, and Tanzania. The percentage recovery of adult worms...Full Text Available

1972-01-01

289

Cathepsin K Null Mice Show Reduced Adiposity during the Rapid Accumulation of Fat Stores

Germ cell tumor development in humans has been proposed to be part of testicular dysgenesis syndrome (TDS), which manifests as undescended testes, sterility, hypospadias, and, in extreme cases,...Full Text Available

2007-12-01

290

Castration and training in a spatial task alter the number of immature neurons in the hippocampus of male mice

Growing evidences indicate that proteases are implicated in adipogenesis and in the onset of obesity. We previously reported that the cysteine protease cathepsin K (ctsk) is overexpressed in the white...Full Text Available

291

Breakdown of the Blood-Brain Barrier during Tick-Borne Encephalitis in Mice Is Not Dependent on CD8⁺ T-Cells

New neurons are generated in the granule cell layer of the dentate gyrus (GCL) throughout adulthood. This process is modulated by many environmental and neurochemical factors. We previously...Full Text Available

2010-05-06

292

Behavioral Defects in Chaperone-Deficient Alzheimer's Disease Model Mice

Tick-borne encephalitis (TBE) virus causes severe encephalitis with serious sequelae in humans. The disease is characterized by fever and debilitating encephalitis that can progress to chronic illness...Full Text Available

293

Balance Between Pro- and Anti-Inflammatory Cytokines in Mice Treated With Centruroides noxius Scorpion Venom

Molecular chaperones protect cells from the deleterious effects of protein misfolding and aggregation. Neurotoxicity of amyloid-beta (Aβ) aggregates and their deposition in senile plaques are...Full Text Available

294

Attenuated Salmonella typhimurium reduces ovalbumin-induced airway inflammation and T-helper type 2 responses in mice

CSV consists of a very complex of molecules and demonstrates significant cellular activities capable of stimulating immune functions in vivo. The purpose of this study was to analyze the effects of...Full Text Available

2006-01-01

295

Atrial natriuretic peptide signal pathway upregulated in stomach of streptozotocin-induced diabetic mice

Cytokines produced by Th2 cells are responsible for the pathogenesis of asthma. Th1-biased immune responses caused by attenuated salmonella have the potential to relieve asthmatic symptoms. We evaluated...Full Text Available

2006-07-01

296

Aspirin Treatment of Mice Infected with Trypanosoma cruzi and Implications for the Pathogenesis of Chagas Disease

AIM: To investigate atrial natriuretic peptide (ANP) secretion from gastric mucosa and the relationship between the ANP/natriuretic peptide receptor type A (NPR-A) pathway and diabetic gastroparesis.METHODS:...Full Text Available

2010-01-07

297

Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?

Chagas disease, caused by infection with Trypanosoma cruzi, is an important cause of cardiovascular disease. It is increasingly clear that parasite-derived prostaglandins potently modulate...Full Text Available

298

Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study

The amyloidoses are the prototype gain of toxic function protein misfolding diseases. As such, several naturally occurring animal models and their inducible variants provided some of the first...Full Text Available

2009-08-20

299

BackgroundMale infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding...Full Text Available

300

Adult-born hippocampal neurons are more numerous, faster-maturing and more involved in behavior in rats than in mice

Even in healthy individuals, aging leads to deterioration in visual acuity, contrast sensitivity, visual field, and dark adaptation. Little is known about the neural mechanisms that drive the...Full Text Available

2010-08-18

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301

Accumulation of Plasmodium berghei-Infected Red Blood Cells in the Brain Is Crucial for the Development of Cerebral Malaria in Mice?

Neurons are born throughout adulthood in the hippocampus and show enhanced plasticity compared to mature neurons. However, there are conflicting reports on whether or not young neurons contribute...Full Text Available

2009-11-18

302

Abnormalities of GATA-1 in Megakaryocytes from Patients with Idiopathic Myelofibrosis

Cerebral malaria is the most severe complication of human infection with Plasmodium falciparum. It was shown that Plasmodium berghei ANKA-induced cerebral malaria was...Full Text Available

2010-09-01

303

AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model

The abnormal megakaryocytopoiesis associated with idiopathic myelofibrosis (IM) plays a role in its pathogenesis. Because mice with defective expression of transcription factor GATA-1 (GATA-1^low...Full Text Available

2005-09-01

304

A conditional transposon-based insertional mutagenesis screen for hepatocellular carcinoma-associated genes in mice

BackgroundObesity is one of the principal causative factors involved in the development of metabolic syndrome. AMP-activated protein kinase (AMPK) is an energy sensor that regulates...Full Text Available

305

A Murine Model to Study the Antibacterial Effect of Copper on Infectivity of Salmonella Enterica Serovar Typhimurium

Here we describe a Sleeping Beauty (SB) transposition system that utilizes a conditional SB transposase allele, which can be activated by Cre...Full Text Available

2009-03-01

306

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice

This study investigated the effect of copper as an antibacterial agent on the infectivity of Salmonella enterica serovar Typhimurium. Mice were infected orally with a standardized dose...Full Text Available

2011-01-01

307

Use of the K88 antigen for in vivo bacterial competition with porcine strains of enteropathogenic Escherichia coli.

Humanin (HN), a 24-residue peptide, was identified as a novel neuroprotective factor and shows anti-cell death activity against a wide spectrum of Alzheimer's disease (AD)-related cytotoxicities, including...Full Text Available

308

Radioiodinated 2-nitrobenzyl carbamates as bioreductive alkylating agents for tissue hypoxia

Infant mice were used to measure the amount of fluid accumulation (enterosorption) in the intestinal tract after oral inoculation of a porcine strain of enteropathogenic Escherichia coli (K88-+, Ent-+). Significant reduction in the amount of fluid found in the intestinal tract was observed if the mice were first inoculated with a K88-possessing, non-enterotoxigenic strain of E. coli. The protection provided is thought to be due to specific competition for attachment sites on cells of the small intestine. PMID:1095492

1975-07-01

309

Inhaled toluene produces pentobarbital-like discriminative stimulus effects in mice

Three N-methylcarbamates of iodonitrobenzyl alcohols (4-iodo-2-nitrobenzyl alcohol 2, 5-iodo-2-nitrobenzyl alcohol 3 and 4-iodo-2,6-dinitrobenzyl alcohol 4) bearing [[sup 125]I] have been prepared and characterized for their lipophilicity, their reduction potentials and the in vivo lability of the radioiodine in healthy mice. Based upon these results, 2 and 4 were tested in tumor-bearing mice showing limited uptake of radioactivity in tumours and a tumor-to-blood ratio of less than 1. Consequently these particular carbamates are not satisfactory as hypoxia imaging agents. (author).

1993-05-01

310

Detection of mice lung cancer by neutron radiography

The abuse of volatile solvents may be due to their ability to produce an intoxication similar to that produced by classical central nervous system depressants such as the barbiturates and ethanol. To evaluate this hypothesis, mice were trained to discriminate pentobarbital from saline injections in a two-lever operant task. Stimulus generalization was examined following 20-min inhalation exposures to toluene (300-5400 ppm). In 8 of 10 subjects, pentobarbital-lever responding occurred following toluene exposure indicating an overlap in the discriminative stimulus properties of toluene and pentobarbital.

1985-10-07

311

"3H thymidine an indicator of benzo(a)pyrene induced lung carcinogenesis: role of quercetin and curcumin

Thermal neutron beam from the TNRF of JRR-3M was utilized for detection of mice lung cancer in vivo. Both the static and real-time neutron imaging were tried. Very strong thermal neutron beam is necessary to detect lung cancers because small changes are hidden by the very large attenuation of thermal neutron beam by the hydrogens in the tissues. The detection was successfully performed. Especially, the Super Eye of Hamamatsu Photonics contributed very effectively. Bone marrows and cartilages were also shown clearly. If an efficient and compact neutron source will become available in future, this method will grow up as a powerful tool for biomedical application. (author).

1995-11-01

312

The growth factor from plerocercoid larvae of the tapeworm, Spirometra mansonoides, stimulates growth but is not diabetogenic.

Full text: Lung cancer is responsible for most of the cancer related deaths and calls for new approaches to control the menace. In the present study chemopreventive efficacy of curcumin and quercetin was investigated against benzo(a)pyrene (BP) induced lung carcinogenesis. The mice were segregated into five groups which included normal control, BP treated, BP+curcumin treated, BP+quercetin treated and BP+curcumin+quercetin treated groups. The morphological and histological analyses of tumor nodules confirmed lung carcinogenesis, after 22 weeks of single i.p. injection of BP at a dose of 100 mg/Kg body weight to mice. Tumor incidence and tumor multiplicity were observed to be 88% and 1.75, respectively in the BP treated mice. A statistically significant increase in the uptake of "3H thymidine indicative of increased DNA synthesis which in turn is the marker of uncontrolled cancer cell proliferation, was observed in the lung ...

313

New approach for in vivo detection of insulitis in type I diabetes: activated lymphocyte targeting with "1"2"3I-labelled interleukin 2

A factor produced by plerocercoids of the tapeworm Spirometra mansonoides is similar to human growth hormone (hGH) in that it stimulates body growth, binds to hGH receptors, cross-reacts with anti-hGH antibodies, and has lactogenic and insulin-like activities. The purpose of this study was to determine whether plerocercoid growth factor (PGF) is similar to hGH in expressing diabetogenic activity in the genetically obese (ob/ob) mouse. To determine an effective dose for use in the obese mice, the ability of daily injections of PGF to stimulate growth of phenotypically normal mice of the same strain was assessed in a 10-day weight gain assay. Injections of PGF stimulated a dose-dependent weight gain (r = 0.83) and 25 ng eq/day of PGF stimulated a response not significantly different from that produced by 100 micrograms of bovine growth hormone/day. Diabetogenicity was assessed using fasting blood glucose and glucose tolerance tests in obese ...

1989-06-01

314

Investigation of genomic instability by assay of DNA fingerprint from the offspring of male mice exposed to chronic low-level #gamma#-radiation

Insulitis is considered the histopathological hallmark of type I diabetes. In the non-obese diabetic (NOD) mouse, diabetes has never been observed in the absence of insulitis. The in vivo detection of insulitis could be of relevance for early prediction of diabetes. As approximately 15% of islet-infiltrating lymphocytes express interleukin 2 receptors, the authors have labelled recombinant inter-leukin 2 with "1"2"3I and used this radiopharmaceutical to detect insulitis by gamma camera imaging. The authors studied 71 prediabetic NOD and 27 normal Balb/c mice. Labelled #alpha#-lactalbumin was used as the control protein. In the first set of experiments the tissue distribution of radiolabelled interleukin 2 in isolated organs from animals sacrificed at different time points was studied. Higher radioactivity was detected in the pancreas of NOD mice injected with labelled interleukin 2, as compared to NOD mice receiving ...

1994-01-01

315

Effect of repeated benzene inhalation exposures on benzene metabolism, binding to hemoglobin, and induction of micronuclei

By polymerase chain reaction with arbitrary primer (AP-PCR), the possibility of transmission of genome instability to somatic cells of the offspring (F_1 generation) from male parents of mice exposed to chronic low-dose #gamma#-radiation was studied. Male mice 15 days after exposure to 10-50 cGy were mated with unirradiated females. Biopsies were taken from tale tips of two month-old mice progeny for DNA separation. Primer in the AP-PCR was 20-mer oligonucleotide flanking the micro-satellite locus Atplb2 on chromosome 11 of the mouse. Comparative analysis of individual fingerprints of AP-PCR products on DNA-templates from the offspring of irradiated and unirradiated male mice revealed an increased variability of micro-satellite-associated sequences in the genome of the offspring of males exposed to 25 and 50 cGy. DNA-fingerprints of the offspring of male mice exposed to chronic ...

2000-11-20

316

Two science communities and coastal wetlands policy

Metabolism of benzene is thought to be necessary to produce the toxic effects, including carcinogenicity, associated with benzene exposure. To extrapolate from the results of rodent studies to potential health risks in man, one must know how benzene metabolism is affected by species, dose, dose rate, and repeated versus single exposures. The purpose of our studies was to determine the effect of repeated inhalation exposures on the metabolism of [14C]benzene by rodents. Benzene metabolism was assessed by characterizing and quantitating urinary metabolites, and by quantitating 14C bound to hemoglobin and micronuclei induction. F344/N rats and B6C3F1 mice were exposed, nose-only, to 600 ppm benzene or to air (control) for 6 hr/day, 5 days/week for 3 weeks. On the last day, both benzene-pretreated and control animals were exposed to 600 ppm, 14C-labeled benzene for 6 hr. Individual benzene metabolites in urine collected for 24 hr after the exposure were analyzed. There ...

317

Shallow hydrothermal regime of the East Brawley and Glamis known geothermal resource areas, Salton Trough, California

This study compares the attitudes of academic and government wetlands scientists about wetlands science and policy. Analysis of one thousand seven hundred responses to Delphi-type questions posed to twenty California scientists on a wide range of issues about California coastal wetlands found significant differences between academic and government scientists about wetlands definitions, threats to wetlands, wetlands policies, wetlands health, and wetlands mitigation strategies. These differences were consistent with descriptive models of political sociology developed by D. Price and C.P. Snow and with normative models of the philosophy of science developed in the renaissance by F. Bacon and R. Descartes. Characteristics, preferences, and personality attributes consistent with group functions and roles have been described in these models. These findings have serious implications for policy. When academic and government wetlands scientists act as ...

1984-01-01

318

Real-time management of water quality in the San Joaquin River Basin, California.

Thermal gradients and thermal conductivities were obtained in real time using an in situ heat-flow technique in 15 shallow (90 to 150 m) wells drilled between Brawley and Glamis in the Imperial Valley, Southern California. The in situ measurements were supplemented by follow-up conventional temperature logs in seven of the wells and by laboratory measurements of thermal conductivity on drill cuttings. The deltaic sedimentary material comprising the upper approx. 100 m of the Salton Trough generally is poorly sorted and high in quartz resulting in quite high thermal conductivities (averaging 2.0 Wm/sup -1/ K/sup -1/ as opposed to 1.2 to 1.7 for typical alluvium). A broad heat-flow anomaly with maximum of about 200 mWm/sup -2/ (approx. 5 HFU) is centered between Glamis and East Brawley and is superimposed on a regional heat-flow high in excess of 100 mWm/sup -2/ (> 2.5 HFU). The heat-flow high corresponds with a gravity maximum and partially with a minimum in ...

1981-01-01

319

Pollution prevention opportunity assessment for Building 922 solid office waste

In the San Joaquin River Basin, California, a realtime water quality forecasting model was developed to help improve the management of saline agricultural and wetland drainage to meet water quality objectives. Predicted salt loads from the water quality forecasting model, SJRIODAY, were consistently within +- 11 percent of actual, within +- 14 percent for seven-day forecasts, and with in +- 26 percent for 14-day forecasts for the 16-month trial period. When the 48 days dominated by rainfall/runoff events were eliminated from the data set, the error bar decreased to +- 9 percent for the model and +- 11 percent and +- 17 percent for the seven-day and 14-day forecasts, respectively. Constraints on the use of the model for salinity management on the San Joaquin River include the number of entities that control or influence water quality and the lack of a centralized authority to direct their activities. The lack of real-time monitoring sensors for other primary ...

1997-09-01

320

Generic assessment of air quality impacts associated with oil and gas development offshore California

Building 922 houses all of SNL/California`s ES and H Departments: Health Protection, Environmental Protection, Safety, and Environmental Operations. It covers approximately 10,000 square feet and houses about 80 people. The office personnel generate nonhazardous solid office wastes in their daily activities. To determine the types and amounts of waste generated, a special PPOA sorting team sorted all of the trash collected from the building for a period of one-week (including paper and aluminum cans in the recycling bins). The team sorted the trash into major categories: paper, plastic, metals, glass, wet garbage, rest room waste, and miscellaneous materials. They then sorted it into subcategories within each major category. Rest room waste was collected but not sorted. The waste in each category was weighed separately. The total amount of trash collected during the week was approximately 168.8 kg (371.4 lbs). The results of this PPOA indicate that ...

1995-01-01

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321

Americans' political participation in the 1993-94 national health care reform debate.

Oil and gas resources in the offshore areas of the US constitute a significant portion of US recoverable hydrocarbon resources. The exploration, development and production of these offshore resources in California, however, could have significant air quality implications for coastal air basins. This study was developed to address a problem that frequently arises with offshore air quality assessments. Typically, such assessments are performed for a specific activity scenario (e.g., a Federal OCS Lease Sale involving a projected number of drilling rigs, platforms, pipelines, etc.) and assume a projected (but uncertain) level of recoverable oil and gas resources. This study enables interested parties to estimate air emissions and impacts for a wide range of OCS-related development scenarios. The modular emission calculation procedure and the generic impact assessment provide for maximum flexibility in reassessing the emissions and impacts should changes in production ...

1984-01-01

322

Use of Behaviorally Anchored Rating Scales (BARS) for deep technical knowledge

The health politics and policy communities are still struggling with the question of "what went wrong" in the 1993-94 health care reform effort. Here I identify which Americans were politically active and inactive during the health care reform debate to explore the role political participation may have had in determining the outcome of the debate. Using data from a national and California random-sample telephone surveys, and controlling for other demographic attributes, I found that those who engaged in political activity specifically related to health care reform were disproportionately more likely to be self-identified conservatives, less likely to favor an employer mandate plan, more likely to be fifty to sixty-four years old, more likely to be men, and more likely to have greater interest in and knowledge of the health care issue. Even in California, where a single-payer proposal was on the November ballot, self-identified liberals were no ...

1996-01-01

323

Three-dimensional cranio-facial computed tomography

The University of California at Los Angeles (UCLA) participated in a U.S. Nuclear Regulatory Commission research program to investigate methods to measure the effect of management and organization on nuclear plant safety. The UCLA research team focused its efforts on understanding {open_quotes}deep technical knowledge,{close_quotes} and its relation to probabilistic risk assessment. As a result, the research team combined deep technical knowledge with a commonly used rating system for understanding the effectiveness of management and organizations.

1993-12-31

324

Scale-dependent errors in the estimation of land-cover proportions. Implications for global land-cover datasets

Computed tomography allows today to reconstruct three-dimensional (eD) images fram axial scans. The authors report their experience in cranio-facial pathology achived in two Departments of Radiology (University of Trieste, Italy and University of Standford, California). 3D images have been realized using two different softwares, one of which allows to reconstruct both soft tissue and bone structures. The application in maxillo-facial traumas, cranio-facial malformations and head tumours are disscussed. 3D images turned out to be very useful for the optimal visualization and for the spatial demostration of the lesion and have potential applications in cranio-facial surgery and radiotherapy.

1986-01-01

325

Aggregation of fine-resolution land-cover maps to coarser scales indicates that estimates of the proportions of land-cover types vary as a function of spatial resolution. The magnitude of these proportional errors in a forested area in northern California increase significantly as resolution exceeds a 90-m threshold. These errors could pose difficulties for the use of land-cover products generated from coarse-resolution sensors such as the NOAA-AVHRR and the MODIS sensor planned for the EOS program. The magnitude of the errors appears to be a function of the spatial resolution of the map, the original size of the land-cover classes, and the spatial patterns of the classes.

1994-05-01

326

Running NUANCE

Presentations from 2nd Cryogenic Operations Workshop (CRYO 2006) , May 9-11, 2006, Menlo Park, California

This article describes version 3.006 of Nuance, an advanced and freely available neutrino generator written by Dave Casper of University of California, Irvine. Source codes of the program are publicly available. This description is based on Dave Casper's article '' The Nuance Neutrino Physics Simulation and the Future '', http://nuint.ps.uci.edu/nuance/files/ nuancenuint01.pdf , Nuance website at http://nuint.ps.uci.edu/ nuance/ , README.txt file provided in the src folder of Nuance distribution, and my own experience as a Nuance user. (author)

2009-09-01

327

Polycrystalline thin films -- Structure, texture, properties and applications III. Materials Research Society symposium proceedings: Volume 472

This workshop covered the latest practical engineering and operational management applications and techniques that have been found to enhance operational costs, reliability, and flexibility, with topics such as establishing the optimal refrigeration design cycle and operating design points; utility management; manpower scheduling; plant control philosophy and automation; short and long term maintenance scheduling; refrigerant loss detection and control; system contamination; component reliability; and equipment technical performance issues.

2006-11-10

328

Polycrystalline thin films -- Structure, texture, properties and applications III. Materials Research Society symposium proceedings: Volume 472

The symposium, Polycrystalline Thin Films - Structure, Texture, Properties, and Applications III, was held at the 1997 Materials Research Society Spring Meeting on March 31--April 4 in San Francisco, California. The topics and investigations were interdisciplinary in nature, and ranged from fundamental to technological. Specifically, the work presented in this volume includes film growth, texture and structural evolution, phase transformation, characterization of grain boundaries and interfaces, stress analysis, and works on polycrystalline Si and SiGe films and devices. Fifty four papers were processed separately for inclusion on the data base.

1997-07-01

329

Local wind patterns for modelling renewable energy systems by means of cluster analysis techniques

The symposium, Polycrystalline Thin Films - Structure, Texture, Properties, and Applications III, was held at the 1997 Materials Research Society Spring Meeting on March 31--April 4 in San Francisco, California. The topics and investigations were interdisciplinary in nature, and ranged from fundamental to technological. Specifically, the work presented in this volume includes film growth, texture and structural evolution, phase transformation, characterization of grain boundaries and interfaces, stress analysis, and works on polycrystalline Si and SiGe films and devices. Fifty four papers were processed separately for inclusion on the data base.

330

Heber Ethanol Fuel Facility, Imperial Valley, California. Quarterly report No. 2, March 1981-May 1981

A method based on cluster analysis techniques is proposed in order to obtain representative local wind patterns. Modeling renewable energy systems, in an accurate way which strongly depends on wind loads, requires reliable data to analyze their response and evaluate their performance. Otherwise poor agreement with the models may be obtained. In a case study for La Paz, Baja California Sur, Mexico, four different wind patterns were obtained from a one-year data set recorded at 10-min intervals. (author)

2002-02-01

331

From biomass to producer gas

The purposed project is a commercial-scale ethanol-fuel facility with a capacity of twenty million gallons per year of fuel-grade ethanol. In addition, 70,000 tons per year of distillers dried grains will be produced. The following tasks and issues are addressed: process engineering - process descriptions, plant layout, and design; economics and finance - overview of capital and operating costs; environmental analysis - preliminary project description; and permit processing and legal issues. (MHR)

1981-08-01

332

Forum: Science and Innovation for Sustainable Development - Opportunities

This article outlines the use of gasifiers during World War II and how, with soaring fuel prices, producer gas may provide an alternate energy path for agribusiness and farms today. In the last few years, the University of California has become a focus of producer gas research in the US. Biomass fuels used include crushed walnut shells, fruit pits, cereal straw and corn cobs. Particle size, moisture content and slagging create problems and the right kind of gas producer must be used to obtain reliable conversion to producer gas.

1980-09-08

333

Wastenet

...assistantship in Suburban Ecology Location: Bedford, NY Deadline: August 15, 2008 Postdoctoral Fellow in energy Location: University of Waterloo, Ontario, Canada Deadline: August 11, 2008 Junior Professional Fellowship Sustainable Development Governance Programme Location: UNU, Yokohama, Japan Deadline: August 1, 2008 Center for Ocean Solutions Early Career Fellowship Program Location: Stanford, California Deadline: July 15, 2008 Asian MetaCentre for Population and Sustainable Development Analysis Postdoctoral Research Fellow Location: Singapore Deadline: July 15, ...

334

FCE power plants for renewable biogas project in San Diego

British Library Electronic Table of Contents (United Kingdom)

FuelCell Energy in Connecticut has sold 4.5 MW worth of power plants to California renewable energy company BioFuels Fuel Cells, part of New Energy Capital and BioFuels Energy. Three molten carbonate fuel cell power plants - a 2.8 MW DFC3000 unit, a 1.4 MW DFC1500 system, and a 300 kW DFC300 unit - will be installed at three locations in the San Diego area, and utilize purified biogas from the Point Loma wastewater treatment plant as their primary fuel source.

2010-01-01

335

Area- and site-specific geothermal leasing/permitting profiles; updated geothermal leasing/permitting performance assessment

Acceptance test report for the Westinghouse 100 ton hydraulic trailer

Sufficient discussion of the elements of the leasing and permitting programs is included to place the information developed in proper context. A table and process flow diagram developed previously which outline the steps in the non-competitive leasing process, is reprinted. Computer printout profiles are presented on 195 identifiable areas in the following states: Arizona, California, Colorado, Idaho, Montana, Nevada, New Mexico, Oregon, Utah, Washington, and Wyoming. Sufficient information on the boundaries of these areas is contained in the report to permit identification of their general location on any map of the appropriate state which shows township and range locations.

1982-02-01

336

A Cloud Computing Approach to Personal Risk Management: The Open Hazards Group

The SY-101 Equipment Removal System 100 Ton Hydraulic Trailer was designed and built by KAMP Systems, Inc. Performance of the Acceptance Test Procedure at KAMP`s facility in Ontario, California (termed Phase 1 in this report) was interrupted by discrepancies noted with the main hydraulic cylinder. The main cylinder was removed and sent to REMCO for repair while the trailer was sent to Lampson`s facility in Pasco, Washington. The Acceptance Test Procedure was modified and performance resumed at Lampson (termed Phase 2 in this report) after receipt of the repaired cylinder. At the successful conclusion of Phase 2 testing the trailer was accepted as meeting all the performance criteria specified.

1995-03-06

337

The effect of intratracheal administration of a surfactant on mortality in a model of murine paraquat poisoning

According to the California Earthquake Authority, only about 12% of current California residences are covered by any form of earthquake insurance, down from about 30% in 1996 following the 1994, M6.7 Northridge earthquake. Part of the reason for this decreasing rate of insurance uptake is the high deductible, either 10% or 15% of the value of the structure, and the relatively high cost of the premiums, as much as thousands of dollars per year. The earthquake insurance industry is composed of the CEA, a public-private partnership; modeling companies that produce damage and loss models similar to the FEMA HAZUS model; and financial companies such as the insurance, reinsurance, and investment banking companies in New York, London, the Cayman Islands, Zurich, Dubai, Singapore, and elsewhere. In setting earthquake insurance rates, financial companies rely on models like HAZUS, that calculate on risk and exposure. In California, ...

2010-12-01

338

Differential regulation of the biosynthesis of glucose transporters by the PI3-K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla.

''Paraquat lung'' which is complicated with paraquat poisoning has been a lethal pulmonary pathology presenting intra-alveolar fibrosis, but an effective therapy has not been developed so far. We hypothesized that the type II alveolar cells producing surfactant were damaged by paraquat which was actively accumulated through out the blood by alveolar epithelial cells. To prove this hypothesis, we examined the effect of an intratracheal administration of an artificial lung surfactant (surfacten, Mitsubishi Tanabe Pharma Corporation, Osaka) on mortality in a model of murine paraquat poisoning. Paraquat was given intramuscularly 3 days after the intratracheal surfactant administration. The mice used were C57BL/6J strain and Balb/C strain. The lethal dose, 50% (LD50), of paraquat was about 28 mg/kg in the C57BL/6J strain and about 9 mg/kg in the Balb/C strain, respectively. Mortalities of paraquat poisoning in both strains of mice improved ...

339

Air quality constraints to statewide power plant siting

The insulin signaling pathway, involving protein kinase B (PKB) and mitogen-activated protein kinase (MAPK), mediates the biological response to insulin and several growth factors and cytokines. To investigate the correlation between glucose transporter (Glut) biosynthesis and the insulin signaling pathway activated by novel compounds of Liriope platyphylla (LP9M80-H), alterations in Glut and key protein expression in the insulin signaling pathway were analyzed in the liver and brain of ICR mice treated with LP9M80-H. An in vitro assay showed that the highest level of insulin concentration was observed in the LP9M80-H-treated group, followed by the LP-H, LP-M, LP-E, and LP9M80-C-treated groups. Therefore, LP9M80-H was selected for use in studying the detailed mechanism of the insulin signaling pathway in animal systems. In an in vivo experiment, LP9M80-H induced a significant increase in glucose levels and a decrease of insulin concentration in the blood of ...

2010-12-14

340

Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice

Those areas in California where synthetic fuel-fired power plants could be sited in the 1990 time frame, from an air quality perspective were identified. The synfuel-fired power plants considered in this new study were 500 MW methanol-fired combined cycle (MFCC) and 500 MW integrated gasifier combined-cycle (IGCC) units. For comparison purposes, 500 MW direct coal-fired boilers and 500 MW natural gas-fired combined-cycle units were also considered. The study provides an approximation, for planning purposes, of a reasonable limit of the state's power plant siting capacity, given the plant types and sizes, conditions, and assumptions specified. The study shows that local emission limitations many times preclude certain types of power plants even when they are equipped with Best Available Control Technology (BACT) as required by NSR regulations. This study also shows that 4000 MW of direct-fired coal plants could potentially be sited in ...

1980-11-01

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341

British Library Electronic Table of Contents (United Kingdom)

Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system. Recently, we found increased gene expression for EphA4, a gene intricately involved in motor neuron development, between high-active parental strain C57BL/6J and the low-active chromosome substitution strain 1 (CSS1). CSS1 mice carry chromosome 1 from A/J mice in a C57BL/6J genetic background, allowing localization of quantitative trait loci (QTL) on chromosome 1. To find out whether differences in motor neuron anatomy, possibly related to the changes in EphA4 expression, are involved in the motor activity differences observed in these strains, motor performance in various behavioral paradigms and anatomical differences in the ventral roots ...

2009-01-01

342

Tumor necrosis factor alpha and interleukin-1 stimulate bone resorption in vivo as measured by urinary ( sup 3 H)tetracycline excretion from prelabeled mice

The radiosensitivity of spermatogonial stem cells in C3H/101 F[sub 1] hybrid mice

Tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) have been shown to stimulate bone resorption in vitro. We have now investigated whether these cytokines also cause a similar action when administered in vivo. This was made possible by the adaptation of a newly developed technique that enables the continual assessment of bone resorption in vivo in mice by measuring urinary excretion of {sup 3}H from ({sup 3}H)tetracycline-prelabeled animals. Experiments using maneuvers known to influence bone resorption, such as a change in dietary calcium or administration of parathyroid hormone or dichloromethylenebisphosphonate, indicate that the technique is reliable and sensitive in mice. Daily intravenous administration of either recombinant human or recombinant murine TNF-alpha, as well as subcutaneous administration of recombinant human IL-1 alpha, were found to stimulate bone resorption in a dose-dependent manner. The effect was maximal ...

1988-12-01

343

Regulation of macrophage accessory cell activity by mycobacteria. I. Ia expression in normal and irradiated mice infected with Mycobacterium mycroti

The radiosensitivity of spermatogonial stem cells of C3H/HeHx101/H F[sub 1] hybrid mice was determined by counting undifferentiated spermatogonia at 10 days after X-irradiation. During the spermatogenic cycle, differences in radiosensitivity were found, which were correlated with the proliferative activity of the spermatogonial stem cells. In stage VIII[sub irr], during quiescence, the spermatogonial stem cells were most radiosensitive with a D[sub 0] of 1.4 Gy. In stages XI[sub irr]-V[sub irr], when the cells were proliferatively active, the D[sub 0] was about 2.6 Gy. Based on the D[sub 0] values for sensitive and resistant spermatogonia and on the D[sub 0] for the total population, a ratio of 45:55% of sensitive to resistant spermatogonial stem cells was estimated for cell killing. When the present data were compared with data on translocation induction obtained in mice of the same genotype, a close fit was obtained when the translocation ...

1993-12-01

344

Medicinal protection with Chinese herb-compound against radiation damage

CBA/Ca mice were infected by either the intravenous or intraperitoneal route with Mycobacterium microti and the subsequent changes in local macrophage populations examined. Following infection, the number of macrophages increased and they showed greater expression of both MHC Class II molecules. This response was not dependent on viability of the mycobacteria, in contrast to reports with other microorganisms such as Listeria. Studies in sublethally irradiated mice indicated that persistent antigen could give rise to a response after a period of host recovery which was radiation dose dependent. This procedure also highlighted differences in the regulation of different murine class II antigens in vivo, as seen by delayed re-expression of I-E antigens. Macrophage accessory cell function, as assessed by an in vitro T cell proliferation assay, correlated with Ia expression after fixation, but not after indomethacin treatment; this highlights the ...

345

Genetic analysis of the psychostimulant effects of nicotine in chromosome substitution strains and F2 crosses derived from A/J and C57BL/6J progenitors

Experiments were carried out on mice and the subjects irradiated for cancer therapy to evaluate the protective efficacy of a Chinese medicinal herb-compound (CMHC). The lethality and the degree of leucopenia caused by radiation in mice medicated with CMHC were significantly less in comparison with control mice (p less than 0.01 and p less than 0.001, respectively). CMHC significantly improved the WBC and the thrombocytes in irradiated workers (p less than 0.01 and p less than 0.001, respectively). The WBC count of 40 patients under radiotherapy while treated with CMHC recovered from 3450 +/- 77/c.mm to 5425 +/- 264/c.mm (p less than 0.001); whereas, in the control group, without any medication, the WBC count dropped significantly (p less than 0.001). Our results revealed the applicabilities of CMHC in protection against radiation damage in spaceflight and in other fields.

1990-08-01

346

British Library Electronic Table of Contents (United Kingdom)

Previous research utilizing the AcB/BcA recombinant congenic strains (RCS) of mice mapped provisional quantitative trait loci (QTLs) for the psychostimulant effects of nicotine to multiple regions on chromosomes 7, 11, 12, 14, 16, and 17. The current study was designed to confirm these QTLs in an A/J (A)??C57Bl/6J (B6) F2 cross and a panel of B6.A chromosome substitution strains (CSS). The panel of B6.A CSS consists of 21 strains, each carrying a different A/J chromosome on a B6 background. The A??B6 F2, CSS, A, and B6 mice were tested for sensitivity to the effects of nicotine on locomotor activity using a computerized open-field apparatus. In A??B6 F2 mice two QTLs were identified which confirm those previously observed in the AcB/BcA RCS. Significant differences in the expression of ...

2009-01-01

347

Examination of thermally polluted water for free living amoebae and testing for their possible pathogenic properties

Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: Effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice

Water and mud samples were collected from canals and rivers which were adjacent to outlets discharging warm water of 3 power plants in Berlin. Downstream samples from 1 bathing resort were also collected. Free living amoebae were isolated from 138 water and 69 mud samples. From these respectively 156 and 73 strains could be cultured and were administered intranasally to mice for pathogenicity tests. Two Acanthamoeba strains from water and 7 from mud could be reisolated from mouse brain and or lungs, although no pathological disorders could be observed. Five Naegleria strains were negative in mouse inoculation tests. Four Acanthamoeba strains which were positive in mice were cultured at + 45 degrees C; no cytopathogenic effects were observed in tissue cultures. Acanthamoeba infective for mice could also be isolated from samples at low water temperatures. Further investigations have to show, whether changes in virulence of ...

1982-05-01

348

British Library Electronic Table of Contents (United Kingdom)

Introduction: We have evaluated the ability of a semi-automated, optomotor reflex method to assess drug-induced visual dysfunction, in albino and pigmented rats and mice. Methods: Male Han Wistar (HW) and Long Evans (LE) rats and mice (CD-1 and C57BL/6) were tested in a chamber formed by 4 computer monitors displaying a rotating vertical grating, to elicit head-tracking movements. The highest visible grating frequency was taken as the threshold of visual acuity, in cycles per degree (c/d). Animals received an intravenous infusion of either sodium iodate (50mg/kg) or 0.9% w/v NaCl (aq). They were tested 2h later, then re-tested daily for a further 3days. The time course of the effect was assessed in HW rats over a 6-week period, including electron microscopy, and immunohistochemical analysi...

2011-01-01

349

Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts

British Library Electronic Table of Contents (United Kingdom)

Abstract Polycystic kidney diseases (PKD) are inherited disorders characterized by fluid-filled cysts primarily in the kidneys. We previously reported differences between the expression of Cux1, p21, and p27 in the cpk and Pkd1 null mouse models of PKD. Embryonic lethality of Pkd1 null mice limits its study to early stages of kidney development. Therefore, we examined mice with a collecting duct specific deletion in the Pkd1 gene. Cux1 was ectopically expressed in the cyst lining epithelial cells of newborn, P7 and P15 Pkd1CD mice. Cux1 expression correlated with cell proliferation in early stages of cystogenesis, however, as the disease progressed, fewer cyst lining cells showed increased cell proliferation. Rather, Cux1 expression in late stage cystogenesis was associated with increased ...

2011-01-01

350

Duration-controlled swimming exercise training induces cardiac hypertrophy in mice.

Changes in contents of somatostatin in hypophysis and arginine vasopressin in hypothalamus of postnatal developing brain induced by low level prenatal #beta#-irradiation of tritiated water in mice

Exercise training associated with robust conditioning can be useful for the study of molecular mechanisms underlying exercise-induced cardiac hypertrophy. A swimming apparatus is described to control training regimens in terms of duration, load, and frequency of exercise. Mice were submitted to 60- vs 90-min session/day, once vs twice a day, with 2 or 4% of the weight of the mouse or no workload attached to the tail, for 4 vs 6 weeks of exercise training. Blood pressure was unchanged in all groups while resting heart rate decreased in the trained groups (8-18%). Skeletal muscle citrate synthase activity, measured spectrophotometrically, increased (45-58%) only as a result of duration and frequency-controlled exercise training, indicating that endurance conditioning was obtained. In groups which received duration and endurance conditioning, cardiac weight (14-25%) and myocyte dimension (13-20%) increased. The best conditioning protocol to promote physiological ...

2003-11-17

351

Body and brain development following exposure to "6"0Co #gamma#-irradiation during pregnancy in mice

Changes in contents of the two kinds of neuropeptides have been measured in the brains of postnatal G57BL/6J strain mice that received accumulative doses of 0, 0.05, 0.10 or 0.30 Gy respectively in utero from tritium #beta#-irradiation during the mother mice's pregnancy from the 12.5th day of gestation to the day of delivery. Dose response relationship for alteration in somatostatin content due to exposure to 0.10 Gy or above was observed, and it was also noted that 0.30 Gy could cause decrease in arginine vasopressin in hypothalamus. These results were consistent with findings in research on brain development and reflex behavior in the literature. 0.10 Gy exposure may represent a threshold for exposure to tritiated water within the range from day 12.5 of gestation to the day of delivery using change in content of somatostatin in hypophysis as a parameter.

352

Modulation of neuronal differentiation by CD40 isoforms

We studied the dose-response effects of #gamma#-irradiation on the weight gains of the body and the brain in ICR mice exposed to various doses of "6"0Co #gamma#-irradiation ranging from 0 to 1.5 Gy on day 13 of pregnancy (E13). We found that 0.5 Gy #gamma#-irradiation caused a significant reduction in brain weight but not in body weight among 6-week-old mice. Higher doses (1.0, 1.5 Gy) seriously inhibited body and brain development, resulting in significantly low weights at 6 weeks of age. A significantly lower brain weight among fetuses exposed to 1.5 Gy was found as early as 24 hours after exposure, while significant reductions in the body weight of these same fetuses appeared 3 days after exposure. The effects of radiation on brain and body development were similar for both males and females. (author).

353

Short-term oral administration of several manganese compounds in mice: Physiological and behavioral alterations caused by different forms of manganese

Neuron differentiation is a complex process involving various cell-cell interactions, and multiple signaling pathways. We showed previously that CD40 is expressed and functional on mouse and human neurons. In neurons, ligation of CD40 protects against serum withdrawal-induced injury and plays a role in survival and differentiation. CD40 deficient mice display neuron dysfunction, aberrant neuron morphologic changes, and associated gross brain abnormalities. Previous studies by Tone and colleagues suggested that five isoforms of CD40 exist with two predominant isoforms expressed in humans: signal-transducible CD40 type I and a C-terminal truncated, non-signal-transducible CD40 type II. We hypothesized that differential expression of CD40 isoform type I and type II in neurons may modulate neuron differentiation. Results show that adult wild-type, and CD40"-"/"- deficient mice predominantly express CD40 type I and II isoforms. Whereas adult ...

2008-05-02

354

Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue

In Kanazawa, Japan, air pollution from a Mn treatment factory was found to affect local junior high school students, who showed reduced respiratory function relative to their exposure to Mn. The use of Mn as an antiknock ingredient in automobile fuels has recently been introduced, placing the general population at risk of chronic low-level exposure. There are few animal studies on the effects of compounds other than manganese chloride (MnCl{sub 2}). In the case of environmental pollution by Mn, the differing physiological effects of the various chemical forms of Mn must be considered. The present study therefore examined the differences in the effects of several Mn compounds on the physiology and behavior of mice by short-term oral administration.

1991-06-01

355

British Library Electronic Table of Contents (United Kingdom)

Fgf receptor 2c (Fgfr2c) was expressed in mature adipocytes of mouse white adipose tissue (WAT). To examine the role of Fgfr2c in mature adipocytes, we generated adipocyte-specific Fgfr2 knockout (Fgfr2 CKO) mice. The hypertrophy impairment of adipocytes in the mesenteric WAT but not in the subcutaneous WAT and decreased plasma free fatty acid (FFA) levels were observed in Fgfr2 CKO mice. Although the expression of genes involved in adipocyte differentiation and lipid metabolism in the mesenteric WAT was essentially unchanged, the expression of uncoupling protein 2 potentially involved in energy dissipation was significantly increased. Among potential Fgf ligands for Fgfr2c, Fgf9 was preferentially expressed in the mesenteric WAT. The present findings indicate that Fgfr2c potentially activ...

2008-01-01

356

Mechanisms involved in the antinociception of petroleum ether fraction from the EtOH extract of Chrysanthemum indicum in mice

British Library Electronic Table of Contents (United Kingdom)

The petroleum ether fraction (PEF) from the EtOH extract of flowers and buds of Chrysanthemum indicum was evaluated on antinociception in mice using chemical and thermal models of nociception. PEF administered orally at doses of 188 and 376mg/kg produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid, subplantar formalin or capsaicin injections and on thermal nociception in the tail-flick test and the hot plate test. In the pentobarbital sodium-induced sleep time test and the open-field test, PEF neither enhanced the pentobarbital sodium-induced sleep time nor impaired the motor performance, indicating that the observed antinociception was unrelated to sedation or motor abnormality. In a measurement of core body temperature, PEF did not affect temper...

2011-01-01

357

Laser Photobiomodulation of Wound Healing: A Review of Experimental Studies in Mouse and Rat Animal Models

British Library Electronic Table of Contents (United Kingdom)

Abstract Objectives: This investigation reviewed experimental studies of laser irradiation of wound healing in mice and rats published from 2003 to August 2008, respectively, to assess putative stimulatory effects of this treatment. Background: Animal models, including rodents, attempt to reflect human wound healing and associated problems such as dehiscence, ischemia, ulceration, infection, and scarring. They have played a key role in furthering understanding of underlying mechanisms involved in impaired wound healing, and in testing new therapeutic strategies including laser irradiation. Method: Original research papers investigating effects of laser or monochromatic light therapy on wound healing in mice and rats and published from January 2003 to August 2008 were retrieved from library...

2010-01-01

358

Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.

Effects of various maillard reaction products on in vitro starch hydrolysis and blood glucose responses in mice

We developed mice with germline endogenous expression of oncogenic Hras to study effects on development and mechanisms of tumor initiation. They had high perinatal mortality, abnormal cranial dimensions, defective dental ameloblasts, and nasal septal deviation, consistent with some of the features of human Costello syndrome. These mice developed papillomas and angiosarcomas, which were associated with Hras(G12V) allelic imbalance and augmented Hras signaling. Endogenous expression of Hras(G12V) was also associated with a higher mutation rate in vivo. Tumor initiation by Hras(G12V) likely requires augmentation of signal output, which in papillomas and angiosarcomas is achieved via increased Hras-gene copy number, which may be favored by a higher mutation frequency in cells expressing the oncoprotein. PMID:19416908

2009-04-29

359

British Library Electronic Table of Contents (United Kingdom)

Abstract This study investigated the effects of Maillard reaction products (MRPs) on in vitro starch hydrolysis, and in vivo blood glucose responses in mice. Four MRPs of various dextrose equivalents were prepared by heating a mixture of hydrolyzed rice starch and glycine at 200C for 4-min. The starch hydrolysis rates of gelatinized rice starch (GRS) decreased as the browning reaction of added MRPs increased. The hydrolysis kinetic constants of the GRS with 5% MRPs were relatively lower than that of GRS without MRPs. Blood glucose responses showed similar tendencies to the in vitro starch hydrolysis results. The activity of digestive enzymes was inhibited by the MRPs. The relative crystallinity of all MRPs (29.9-60.1%) appeared to have higher values than GRS (15.1%). The samples heated to ...

2011-01-01

360

Detection of behavioral alterations and learning deficits in mice lacking synaptophysin

British Library Electronic Table of Contents (United Kingdom)

The integral membrane protein synaptophysin is one of the most abundant polypeptide components of synaptic vesicles. It is not essential for neurotransmission despite its abundance but is believed to modulate the efficiency of the synaptic vesicle cycle. Detailed behavioral analyses were therefore performed on synaptophysin knockout mice to test whether synaptophysin affects higher brain functions. We find that these animals are more exploratory than their wild type counterparts examining novel objects more closely and intensely in an enriched open field arena. We also detect impairments in learning and memory, most notably reduced object novelty recognition and reduced spatial learning. These deficits are unlikely caused by impaired vision, since all electroretinographic parameters measur...

2009-01-01

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361

DNFB-DNS hapten-induced colitis in mice should not be considered a model of inflammatory bowel disease

British Library Electronic Table of Contents (United Kingdom)

AbstractBackground: The dinitrofluorobenzene/dinitrosulfonic acid (DNFB/DNS) model was originally described as an experimental model of intestinal inflammation resembling human ulcerative colitis (UC). Due to the absence of acceptable UC experimental models for pharmacological preclinical assays, here we examine the immune response induced in this model. Methods: Balb/c mice were sensitized by skin application of DNFB on day 1, followed by an intrarectal challenge with DNS on day 5. We further expanded this model by administering a second DNS challenge on day 15. The features of colonic inflammation and immune response were evaluated. Results: The changes observed in colonic tissue corresponded, in comparison to the trinitrobenzene sulfonic acid (TNBS) colitis model, to a mild mucosal effe...

2011-01-01

362

Cumulative effect of X-ray radiation and inflammatory reaction on the circadian rhythm of tyrosine aminotransferase in the liver of mice

Activity of ginsenoside Rh2 on the growth of mice splenic lymphocytes investigated by microcalorimetry and factor analysis

The activity of tyrosine aminotransferase (TAT) in the liver of mice subjected simultaneously to ionizing radiation and to local inflammatory process showed in the first 24 hours of the experiment statistically significant changes resulting from summation of the harmful effects of both factors. In the second 24-hour period an evident tendency was observed for return of a normal circadian rhythm of the enzyme. This points to presence of an endogenous mechanism of suppression of the manifestations of significant desynchronization of the circadian rhythm. The paper contains also a trial of mathematical analysis of changes in TAT activity in the circadian rhythm, a description and analysis or the suppression process, qualitative and quantitative determination of the phenomenon of cumulation of the effects of powerful stress factors acting on the animal organism. The obtained results were compared with the results of investigations of TAT activity changes obtained in ...

1980-01-01

363

British Library Electronic Table of Contents (United Kingdom)

The power?time curves of mice splenic lymphocytes growth at 37??C affected by ginsenoside Rh2 were determined by microcalorimetry using a 3114/3236 TAM air bioactivity monitor with ampoule mode. Then, the minimal inhibitory concentration (MIC) of Rh2 on splenic lymphocytes growth was determined by serial dilution method. From factor analysis (FA) on six quantitative thermokinetic parameters from the power?time curves, the activity of Rh2 on splenic lymphocytes could be quickly evaluated by analyzing the changes in the two main parameters: growth rate constant k, and maximum heat-output power, P m. The results showed that Rh2 had strong inhibitory activity on splenic lymphocytes growth, and this inhibitory activity was strengthened with increasing concentration of Rh2 in the concentration r...

2011-01-01

364

Up-Regulation of the RhoA/Rho-Kinase Signaling Pathway in Corpus Cavernosum from Endothelial Nitric-Oxide Synthase (NOS), but Not Neuronal NOS, Null Mice

Two subpopulations of stem cells for T cell lineage

We tested the hypothesis that the basal release of nitric oxide (NO) from endothelial cells modulates contractile activity in the corpus cavernosum (CC) via inhibition of the RhoA/Rho-kinase signaling...Full Text Available

2010-04-01

365

Tissue tropism and neuroinvasion of West Nile virus do not differ for two mouse strains with different survival rates

An assay system for the stem cell that colonizes the thymus and differentiates into T cells was developed, and by using this assay system the existence of two subpopulations of stem cells for T cell lineage was clarified. Part-body-shielded and 900-R-irradiated C57BL/6 (H-2b, Thy-1.2) recipient mice, which do not require the transfer of pluripotent stem cells for their survival, were transferred with cells from B10 X Thy-1.1 (H-2b, Thy-1.1) donor mice. The reconstitution of the recipient's thymus lymphocytes was accomplished by stem cells in the donor cells and those spared in the shielded portion of the recipient that competitively colonize the thymus. Thus, the stem cell activity of donor cells can be evaluated by determining the proportion of donor-type (Thy-1.1+) cells in the recipient's thymus. Bone marrow cells were the most potent source of stem cells. By contrast, when the stem cell activity was compared between spleen ...

1985-11-01

366

The unique hypusine modification of eIF5A promotes islet ? cell inflammation and dysfunction in mice

West Nile virus (WNV) is a mosquito-borne flavivirus that infects the central nervous system of humans and other animals. In this study, we found that C3H/HeN (C3H) mice exhibited a higher morbidity...Full Text Available

2007-11-25

367

The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.

In both type 1 and type 2 diabetes, pancreatic islet dysfunction results in part from cytokine-mediated inflammation. The ubiquitous eukaryotic translation initiation factor 5A (eIF5A), which is the...Full Text Available

2010-06-01

368

The loss of lead in biological materials following different drying and ashing procedures

In neurodegenerative conditions such as Alzheimer's and prion disease it has been shown that host genetic background can have a significant effect on susceptibility. Indeed, human genome-wide association studies (GWAS) have implicated several candidate genes. Understanding such genetic susceptibility is relevant to risks of developing variant CJD (vCJD) in populations exposed to bovine spongiform encephalopathy (BSE) and understanding mechanisms of neurodegeneration. In mice, aspects of prion disease susceptibility can be modelled by examining the incubation period following experimental inoculation. Quantitative trait linkage studies have already identified multiple candidate genes; however, it is also possible to take an individual candidate gene approach. Rarb and Stmn2 were selected as candidates based on the known association with vCJD. Because of the increasing overlap described between prion and Alzheimer's diseases we also chose Clu, Picalm and Cr1, which ...

2010-12-06

369

The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen

The loss of lead in various kinds of biological materials after drying and ashing is studied by using "2"0"3Pb as tracer which is intravenously injected into mice. The experimental results show that although the oven ashing can be used for determining the lead in samples of lung, kidney, and liver, etc., the oxygen plasma and high pressure digestion are the most suitable methods for the determination of lead in biological materials. (author) 5 refs.; 2 tabs.

370

The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

Pulmonary fibrosis was produced in mice treated with butylated hydroxytoluene (BHT) 400 mg/kg and immediately exposed to 80% oxygen for 3 days. This treatment regimen resulted in 47% mortality. Surviving mice exhibited significant accumulations of pulmonary collagen as evidence by increases in total lung hydroxyproline levels. The administration of indomethacin (4 mg/kg/day) on days 1-6 after BHT decreased mortality to 14% and diminished the accumulation of collagen in lung tissue. Indomethacin also enhanced survival when administered on days 1-3 after BHT/O/sub 2/ but had no effect on lung collagen levels. Treatment with indomethacin on days 4-6 after BHT had no beneficial effect. The administration of prednisolone (60 mg/kg/day) on days 1-3, 1-6, or 4-6 after BHT decreased mortality but had not effect on accumulation of lung collagen. Cis-4-hydroxyproline (400 mg/kg/day) also had no effect on pulmonary fibrosis but did enhance survival when ...

1981-01-01

371

Salmonella enterica Serovar Typhimurium Expressing a Chromosomally Integrated Copy of the Bacillus anthracis Protective Antigen Gene Protects Mice against an Anthrax Spore Challenge

Werner syndrome (WS) is a rare disorder characterized by the premature onset of several pathologies associated with aging. The gene responsible for WS codes for a RecQ-type DNA helicase and is believed...Full Text Available

372

Radiochemistry of lead-203 for radiolabelling antibody conjugates

Protective immunity against infection with Bacillus anthracis is almost entirely based on a response to the protective antigen (PA), the binding moiety for the two other toxin components....Full Text Available

2003-07-01

373

Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization

Lead-203 [52.1 h, 279 (80.1%) KeV] has been recognized as a potentially useful tracer for tumor specific radiopharmaceuticals due to its favorable nuclear and chemical properties. This paper reports the cyclotron production of lead-203 and the labelling of monoclonal antibody B72.3, conjugated with 2-(p-isothiocyanatobenzyl)DOTA, with lead-203 in 30% yield. In vivo biodistribution and stability studies in mice are being conducted.

1990-06-24

374

British Library Electronic Table of Contents (United Kingdom)

With collaboration between chemistry, X-ray crystallography, and molecular modeling, we designed and synthesized a series of novel piperazine sulfonamide BACE1 inhibitors. Iterative exploration of the non-prime side and S2prime sub-pocket of the enzyme culminated in identification of an analog that potently lowers peripheral Ab40 in transgenic mice with a single subcutaneous dose.

2010-01-01

375

Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

Neuropilin-1/GIPC1 Signaling Regulates ?5?1 Integrin Traffic and Function in Endothelial Cells

BackgroundAmplification of 3q26 is one of the most frequent genetic alterations in many human malignancies. Recently, we isolated a novel oncogene eIF-5A2 within...Full Text Available

376

Near-Infrared Fluorescence Labeled Anti-TAG-72 Monoclonal Antibodies for Tumor Imaging in Colorectal Cancer Xenograft Mice

Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, Nrp1 null embryos display vascular...Full Text Available

2009-01-01

377

Mice With a Deletion in the Gene for CCAAT/Enhancer-Binding Protein ? are Protected Against Diet-Induced Obesity

Anti-TAG-72 monoclonal antibodies target the tumor-associated glycoprotein (TAG)-72 in various solid tumors. This study evaluated the use of anti-TAG-72 monoclonal antibodies, both murine CC49...Full Text Available

2009-01-01

378

Mice Deficient in N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase Are Unable to Synthesize Chondroitin/Dermatan Sulfate containing N-Acetylgalactosamine 4,6-Bissulfate Residues and Exhibit Decreased Protease Activity in Bone Marrow-derived Mast Cells*

The CCAAT/enhancer-binding protein β (C/EBPβ) is required for adipocyte differentiation and maturation. We have studied the role of the transcription factor, C/EBPβ,...Full Text Available

2007-01-01

379

Mapping of TH1 helper T-cell epitopes on major secreted mycobacterial antigen 85A in mice infected with live Mycobacterium bovis BCG.

Chondroitin sulfate (CS) and dermatan sulfate (DS) containing N-acetylgalactosamine 4,6-bissulfate (GalNAc(4,6-SO₄)) show various physiological activities through interacting...Full Text Available

2010-07-02

380

Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy(SUDEP)

TH1 cytokine secretion was examined in response to synthetic peptides of the 85A component of the major secreted, fibronectin-binding antigen 85 complex from Mycobacterium tuberculosis in seven different...Full Text Available

1994-02-01

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381

Inhibition of Melanoma Growth by Subcutaneous Administration of hTERTC27 Viral Cocktail in C57BL/6 Mice

Mice lacking Kv1.1 Shaker-like potassium channels encoded by the Kcna1 gene exhibit severe seizures and die prematurely. The channel is widely expressed in...Full Text Available

2010-04-14

382

In vivo^99mTc-HYNIC-annexin V imaging of early tumor apoptosis in mice after single dose irradiation

BackgroundhTERTC27 is a 27 kDa C-terminal polypeptide of human telomerase reverse transcriptase that has previously been shown to reduce tumorigenicity of HeLa cells and suppress...Full Text Available

383

Genetic and somatic effects in animals maintained on tritiated water

BackgroundApoptosis is a major mode of hematological tumor death after radiation. Early detection of apoptosis may be beneficial for cancer adaptive treatment. ^99mTc-HYNIC-annexinV...Full Text Available

384

Effects of electromagnetic pollution on human health discussed

The possible genetic (dominant lethal mutations (DLM) and cytogenetic changes in the regenerating liver) and somatic (hematopoietic stem cell changes, growth and nonspecific life time shortening) effects in mice maintained on tritiated water (HTO) over two generations was investigated. Results to date are summarized. (ACR)

1981-01-01

385

Dual protective role for Glutathione S-transferase class pi against VCD-induced ovotoxicity in the rat ovary1

The harmful effects of high-intensity electric fields on human beings are discussed. Formulas for determining the field strength of high voltage transmission lines and track lines and experimental data of these effects on mice are given. Protective measures from these hazards are introduced. 18 references, 7 figures, 5 tables.

1982-01-01

386

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice

The occupational chemical 4-vinylcyclohexene diepoxide (VCD) selectively destroys ovarian small pre-antral follicles in rats and mice via apoptosis. Detoxification of VCD can occur through glutathione...Full Text Available

2010-09-01

387

Developmentally regulated expression of a 78 kDa erythroblast membrane glycoprotein immunologically related to the platelet thrombospondin receptor.

Little is known about how diet and energy metabolism interact in determination of lifespan under ad libitum feeding. From 12 weeks of age until death, male and female wild-type (WT) and transgenic (TG)...Full Text Available

2011-02-01

388

Deficiency in trefoil factor 1 (TFF1) increases tumorigenicity of human breast cancer cells and mammary tumor development in TFF1-knockout mice

We have previously described a monoclonal antibody (FA6-152), obtained by immunizing mice with fetal human erythrocytes [Edelman, Vinci, Villeval, Vainchenker, Henri, Miglierina, Rouger, Reviron, Breton-Gorius,...Full Text Available

1989-09-15

389

Decreased 7,12-dimethylbenz[a]anthracene-induced carcinogenesis coincides with the induction of antitumor immunities in adult female B6C3F1 mice pretreated with genistein

Although trefoil factor 1 (TFF1; previously named pS2) is abnormally expressed in about 50% of human breast tumors, its physiopathological role in this disease has been poorly studied. Moreover,...Full Text Available

2011-07-21

390

DIMINISHED DEGRADATION OF MYELIN BASIC PROTEIN BY ANTI-SULFATIDE ANTIBODY AND INTERFERON-? IN MYELIN FROM GLIA MATURATION FACTOR-DEFICIENT MICE

The objective of this study was to determine if genistein (GEN) modulation of the immune responses might contribute to the increased host resistances to tumors. A time-course study was performed...Full Text Available

2007-12-01

391

Characterization of neurotoxic effects of NMDA and the novel neuroprotection by phytopolyphenols in mice.

In this study we show the effect of anti-sulfatide (RmAb) antibodies and inflammatory cytokines, TNF-α and IFN-γ in inducing myelin basic protein (MBP) degradation in myelin...Full Text Available

2007-06-01

392

C57BL/6J, DBA/2J, and DBA/2J.Gpnmb⁺ mice have different visual signal processing in the inner retina

Excitotoxicity plays a major role in various neurological disorders. In this study, we explored the behavioral and neurotoxic effects of intraventricular NMDA administration in mice. After NMDA injection, acute seizures were followed by impairments in locomotor activity, motor performance on a rotarod, and climbing ability. Mice killed 1 day after NMDA administration showed increased synaptosomal reactive oxygen species ROS production and calcium concentration and decreased mitochondrial membrane potential, mitochondrial reductase activities, and neuronal membrane Na+, K+ -ATPase and mg2+ -ATPase activities. One and 3 days after excitotoxic injury, Golgi stains showed that dendritic length and spine density were significantly decreased in neurons of the hippocampal dentate gyrus. Some mice received honokiol, tea polyphenol plus memantine, and honokiol plus memantine prior to NMDA treatment; the occurrence of generalized ...

2010-08-01

393

Behavioral Stress May Increase the Rewarding Valence of Cocaine-Associated Cues Through a Dynorphin/?-Opioid Receptor-Mediated Mechanism without Affecting Associative Learning or Memory Retrieval Mechanisms

PurposeTo characterize differences in retinal ganglion cell (RGC) function in mouse strains relevant to disease models. C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse...Full Text Available

394

Attenuation by methyl mercury and mercuric sulfide of pentobarbital induced hypnotic tolerance in mice through inhibition of ATPase activities and nitric oxide production in cerebral cortex

Stress exposure increases the risk of addictive drug use in human and animal models of drug addiction by mechanisms that are not completely understood. Mice subjected to repeated forced swim stress...Full Text Available

2010-08-01

395

Amplified B Lymphocyte CD40 Signaling Drives Regulatory B10 Cell Expansion in Mice

This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a short period (7 days) of oral administration to mice, a nontoxic dose (0.1 g/kg) of HgS not only significantly enhanced pentobarbital-induced hypnosis but also attenuated tolerance induction; while a higher dose (1 g/kg) of HgS or cinnabar exerted an almost irreversible enhancing effect on pentobarbital-hypnosis similar to that of MeHg (2 mg/kg) tested, which was still effective even after 10 or 35 days cessation of administration. To study comparatively the effects of different mercury forms from oral administration of MeHg and HgS on membrane ATPase activities of experimental mice, analysis of the Hg content in ...

2008-06-15

396

Altered GABA_A receptor-mediated synaptic transmission disrupts the firing of gonadotropin-releasing hormone neurons in male mice under conditions that mimic steroid abuse

BackgroundAberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role...Full Text Available

397

Accumulation and excretion of metabolized "1"0"6Ru in prawn meat ingested by mice

Gonadotropin–releasing hormone (GnRH) neurons are the central regulators of reproduction. GABAergic transmission plays a critical role in pubertal activation of pulsatile GnRH secretion....Full Text Available

2010-05-12

398

Acceleration of the development of benzopyrene-induced skin cancer in mice by microwave radiation

This paper aims at the study of the transfer and accumulation of "1"0"6Ru from marine foods to man through the grazing food chain and evaluation of the radiation exposure to man. As a model, accumulation and excretion of "1"0"6Ru in mice orally administered by the meat of prawn (Penaeus japonicus) which accumulated the radionuclide from the sea water, were examined and compared with those in mice administered by non-radioactive prawn meat mixed with the contaminant in inorganic chemical forms (the control diet); on the latter experiment, the previous evaluation method of the radiation exposure was based. Higher concentrations of "1"0"6Ru in tissues and organs of mice were observed in the former diet than in the latter because of the higher absorption rate of "1"0"6Ru from the gastrointestinal tract (17.4 +- 4.4%, the control diet: 0.7 +- 0.7%) and smaller excretion. As the results of this experiment, the critical organs for ...

399

A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice

In the present study Balb/c mice were exposed to 3,4-benzopyrene, painted on the skin every 2nd day for a total of 6 months, and simultaneously irradiated with athermal (5 mW/cm/sup 2/) or subthermal (15 mW/cm/sup 2/) doses of 2,450 MHz microwaves. The other group of animals was preirradiated with microwaves at 10 mW/cm/sup 2/ power level for 1, 2, or 3 months and then treated with benzopyrene, as above. Control mice were exposed for 6 months to benzopyrene, resulting in the development of baso- or spinocellular skin carcinoma within approximately 9 months, and sham-irradiated with microwaves. The growth of the tumour was assessed according to a self-designed 7-range macroscopic scale, supported by microscopical examinations of skin sections. All protocols of microwave irradiations resulted in a significant acceleration of the development of benzopyrene-induced skin cancer and in shortening of life span of the tumour-bearing hosts. This effect ...

1982-12-01

400

?_1A/B-Knockout mice explain the native ?_1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other ?₁-subtypes

Amyloid plaques are a characteristic feature in Alzheimer’s disease (AD). A novel non-toxic contrast agent is presented, Gd-DTPA-K6Aβ1–30, which is homologous to Aβ,...Full Text Available

2008-06-01

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401

1,1-Dichloroethylene hepatotoxicity: Proposed mechanism of action and distribution and binding of ¹⁴C radioactivity following inhalation exposure in rats

Background and purpose:Theoretically, three α₁-adrenoceptor subtypes can interact at the signalling level to alter vascular contraction or at the molecular level...Full Text Available

2009-12-01

402

Using Multimedia Learning Modules in a Hybrid-Online Course in Electricity and Magnetism

1,1-Dichloroethylene is reported to produce renal tumors in male mice. It is an hepatotoxin in fasted rats after inhalation. We found that trichloropropane epoxide, an inhibitor of epoxide hydrase,...Full Text Available

1977-12-01

403

Use of geothermal heat for sugar refining in Imperial County. Final report, Phase I

We have been piloting web-based multimedia learning modules (MLMs), developed by the Physics Education Research Group at the University of Illinois at Urbana Champaign (UIUC), as a "prelecture assignment" in several introductory physics courses at California State Polytechnic University at Pomona. In this study, we report the results from a controlled study utilizing modules on electricity and magnetism as a part of a blended hybrid-online course. We asked students in the experimental section to view the MLMs prior to attending the face-to-face class, and to make sure this would not result in additional instructional time, we reduced the weekly class time by one-third. We found that despite reduced class time, student-learning outcomes were not hindered; in fact, the implementation of the UIUC MLMs resulted in a positive effect on student performance on conceptual tests and classroom discussion questions. (Contains 4 figures and 1 table.)

2010-12-01

404

Thermo-economic analysis of solar powered adsorption heat pump

The objective of the three-phase Holly Sugar Geothermal Project was to replace fossil fuels with geothermal energy for sugar beet processing at the Holly Sugar plant located in Brawley, California, in a technically straightforward, economically sound and environmentally acceptable manner. The first phase of the project, discussed in this final report, encompassed the design and analysis of a geothermal industrial heat system for Holly Sugar and addresses: (1) assessment of the geothermal resource; (2) development of a preliminary system design; (3) analysis and publication of an environmental analysis and monitoring report; (4) preliminary economic analyses; (5) dissemination of project related information; and (6) the development of a proposal for the follow-on phases.

1980-12-01

405

British Library Electronic Table of Contents (United Kingdom)

The economic feasibility of the residential solar thermal (ST) cooling system designed in the companion article [1] is ascertained by comparing it with a solar electric (SE) cooling system, and also with the baseline (i.e., control case), a grid dependent, highest efficiency COPC=5.66 heat pump. The economic scenario is analyzed for 24 cities across the southern USA, south of the 37degreeN. The SE cooling system provides lifecycle (20 year) savings to the homeowner only where electric rates are high and it is heavily subsidized. The overall societal effect (sum of taxpayer funded rebate and homeowner savings) is actually an increased cost everywhere except the California Central Valley, where the net savings is $1500. In the same valley, The ST cooling system provides greater lifecycle sav...

2007-01-01

406

The engineering institute of Los Alamos National Laboratory

Survey of the marine benthic infauna collected from the United States radioactive waste disposal sites off the Farallon Islands, California. Final report

Los Alamos National Laboratory (LANL) and the University of California, San Diego (UCSD) have taken the unprecedented step of creating a collaborative, multi-disciplinary graduate education program and associated research agenda called the Engineering Institute. The mission of the Engineering Institute is to develop a comprehensive approach for conducting LANL mission-driven, multidisciplinary engineering research and to improve recruiting, revitalization, and retention of the current and future staff necessary to support the LANL' s national security responsibilities. The components of the Engineering Institute are (1) a joint LANL/UCSD degree program, (2) joint LANL/UCSD research projects, (3) the Los Alamos Dynamic Summer School, (4) an annual workshop, and (5) industry short courses. This program is a possible model for future industry/government interactions with university partners.

2008-01-01

407

Submegahertz linewidth at 240 GHz from an injection-locked free-electron laser

Benthic biological samples were taken in 1977 from the vicinity of the Farallon Islands radioactive waste disposal sites for characterization of the infaunal macroinvertebrates and foraminifera. A total of 120 invertebrate species were collected, of which 75 species (63 percent) were polychaetes. Forty-three of these polychaete species have not previously been reported from depths greater than 1000m. A total of 1044 macroinvertebrate specimens were collected of which 54 percent were polychates. Only the nematods were present at all six benthic stations, but the community structure was dominated by the polychaetes Tauberia gracilis, Allia pulchra, Chaetozone setosa, and Cossura candida. Living and dead foraminifera were reported. The possible role of polychaetes in bioturbation and in the marine food chain is briefly discussed with respect to the various polychaete feeding mechanisms.

408

Stabilization of geothermal residues by encapsulation in portland cement-based composites

Radiation from an ultrastable 240 GHz solid state source has been injected, through an isolator, into the cavity of the University of California, Santa Barbara millimeter-wave free-electron laser (FEL). High-power FEL emission, normally distributed among many of the cavity's longitudinal modes, is concentrated into the single mode to which the solid state source has been tuned. The linewidth of the FEL emission is 0.5 MHz, consistent with the Fourier transform limit for the 2 #mu#s pulses. This demonstration of frequency-stable, ultranarrow-band FEL emission is a critical milestone on the road to FEL-based pulsed electron paramagnetic resonance spectroscopy.

2007-10-22

409

Sandia`s network for supercomputing `95: Validating the progress of Asynchronous Transfer Mode (ATM) switching

Presented are the results from a laboratory test program conducted to identify and evaluate materials for converting hazardous geothermal residues to a non-hazardous and potentially usable form. Results indicate that the residues can be effectively incorporated, as a fine aggregate, into portland cement-based composites. Five geothermal residues obtained from sites in the Salton Sea area of California were evaluated. Three of these were classified as hazardous. After mixing with cement, the leach rates were all well below specified levels. Although structural-grade composites were produced, gradual reductions in properties with time up to 1 yr were noted. This indicates ongoing chemical reactions between the cement paste and the constituents of the residues. Further research is necessary before the composites could be considered for use in structural applications. 3 refs., 8 tabs.

1988-05-01

410

SCE go-ahead for 100-MW coal fired combined cycle plant

The Advanced Networking Integration Department at Sandia National Laboratories has used the annual Supercomputing conference sponsored by the IEEE and ACM for the past three years as a forum to demonstrate and focus communication and networking developments. For Supercomputing `95, Sandia elected: to demonstrate the functionality and capability of an AT&T Globeview 20Gbps Asynchronous Transfer Mode (ATM) switch, which represents the core of Sandia`s corporate network, to build and utilize a three node 622 megabit per second Paragon network, and to extend the DOD`s ACTS ATM Internet from Sandia, New Mexico to the conference`s show floor in San Diego, California, for video demonstrations. This paper documents those accomplishments, discusses the details of their implementation, and describes how these demonstrations supports Sandia`s overall strategies in ATM networking.

1996-04-01

411

Oil-tanker waste-disposal practices: A review

Preliminary plans for the 90 to 100-MW coal-fired combined cycle plant due to be built by a team headed by Southern California Edison and Texaco in the mid-1980s are reviewed. The basic operating goals call for having a gasifier with a 1,000 ton coal capacity per day feeding a 70-MW turbine which then provides waste heat to run a 30-MW steam turbine. Texaco will have responsibility for the gasifier part of the facility with the turbine-generator vendor charged with providing both gas and steam turbine equipment. If the 100-MW demonstration plant achieves 32 to 33% design efficiency, then a commercial plant with expansion turbines and steam reheat should hit 38% and require 20 to 30% less water than a conventional coal fired plant.

1980-01-01

412

Invariance, groups, and non-uniqueness: The discrete case

In the spring of 1991, the Environmental Protection Agency, Region 10 (EPA), launched an investigation into tanker waste disposal practices for vessels discharging ballast water at the Alyeska Pipeline Services Company's Ballast Water Treatment (BWT) facility and marine terminal in Valdez, Alaska. It had been alleged that the Exxon Shipping Company was transferring 'toxic wastes originating in California' to Valdez. In response, EPA decided to examine all waste streams generated on board and determine what the fate of these wastes were in addition to investigating the Exxon specific charges. An extensive Information Request was generated and sent to the shipping companies that operate vessels transporting Alaska North Slope Crude. Findings included information on cargo and fuel tank washings, cleaning agents, and engine room waste.

1992-01-01

413

Improving Dynamic Load and Generator Response PerformanceTools

Lie group methods provide a valuable tool for examininginvariance and non-uniqueness associated with geophysical inverseproblems. The techniques are particularly well suited for the study ofnon-linear inverse problems. Using the infinitesimal generators of thegroup it is possible to move within the null space in an iterativefashion. The key computational step in determining the symmetry groupsassociated with an inverse problem is the singular value decomposition(SVD) of a sparse matrix. I apply the methodology to the eikonal equationand examine the possible solutions associated with a crosswelltomographic experiment. Results from a synthetic test indicate that it ispossible to vary the velocity model significantly and still fit thereference arrival times. the approach is also applied to data fromcorosswell surveys conducted before and after a CO2 injection at the LostHills field in California. The results highlight the fact that a faultcross-cutting the region ...

2005-03-24

414

This report is a scoping study to examine research opportunities to improve the accuracy of the system dynamic load and generator models, data and performance assessment tools used by CAISO operations engineers and planning engineers, as well as those used by their counterparts at the California utilities, to establish safe operating margins. Model-based simulations are commonly used to assess the impact of credible contingencies in order to determine system operating limits (path ratings, etc.) to ensure compliance with NERC and WECC reliability requirements. Improved models and a better understanding of the impact of uncertainties in these models will increase the reliability of grid operations by allowing operators to more accurately study system voltage problems and the dynamic stability response of the system to disturbances.

2005-11-01

415

HVAC for energy showcase

Flight songs of Dusky Flycatchers: a response to bird-hunting raptors?

Southern California Gas Co.`s (SoCalGas) Energy Resource Center (ERC) in Downey, Calif. is a 45,000 ft{sup 2} (4,181 m{sup 21}) conference and education center created to help energy decision-makers find the most energy-efficient, cost-effective and environment-sensitive solutions to their energy requirements. The center has 36,000 ft{sup 2} (3,344 m{sup 2}) of remodeled space and 9,000 ft{sup 2} (836 m{sup 2}) of new space, all designed to showcase the latest energy-efficient and environment-sensitive technologies. The building is one of the 25 buildings in the US to be designated as Energy Star Showcase buildings by the US Environmental Protection Agency.

1997-07-01

416

British Library Electronic Table of Contents (United Kingdom)

ABSTRACT. Flight-song displays usually include distinctive vocalizations and behaviors that are probably energetically expensive and also likely to attract the attention of aerial predators. We observed flight songs performed by Dusky Flycatchers (Empidonax oberholseri) in two breeding populations. During 15 yr at Tioga Pass, California, we observed the display twice and, during 9 yr at Steamboat Mountain, British Columbia, we observed 21 flight-song displays. These displays were generally observed later in the breeding season, suggesting that they were not used for courtship, mate attraction, or territory defense. However, for 83% of these displays, a raptor was observed to be present, usually either an American Kestrel (Falco sparverius) or a Sharp-shinned Hawk (Accipiter striatus). We h...

2010-01-01

417

Environmental implications of electric cars

Enthalpy and mass flowrate measurements for two-phase geothermal production by Tracer dilution techniques

California and the Northeast states have passed laws requiring 2% of 1998 cars be `0` emissions vehicles such as electric cars. Electric vehicle technology also can move emissions to less crowd and less polluted locations. However, some other problems remain. The authors focus on the environmental consequences of producing and reprocessing large quantities of batteries to power electric cars, including discussions of both characteristics of Electric Vehicles and batteries and the life cycle of lead and the problems of environmental releases. The authors conclude that electric vehicles will not be in the public interest until they pose no greater threat to public health and the environment than do alternative technologies such as vehicles using low-emission gasoline. 19 refs., 1 tab.

1995-05-19

418

Dual-fuel engine conversions evaluated by U.S. Navy

A new technique has been developed for the measurement of steam mass flowrate, water mass flowrate and total enthalpy of two-phase fluids produced from geothermal wells. The method involves precisely metered injection of liquid and vapor phase tracers into the two-phase production pipeline and concurrent sampling of each phase downstream of the injection point. Subsequent chemical analysis of the steam and water samples for tracer content enables the calculation of mass flowrate for each phase given the known mass injection rates of tracer. This technique has now been used extensively at the Coso geothermal project, owned and operated by California Energy Company. Initial validation of the method was performed at the Roosevelt Hot Springs geothermal project on wells producing to individual production separators equipped with orificeplate flowmeters for each phase.

1993-01-28

419

Development of Point Arguello field, offshore California

In seeking ways to reduce emissions from two-stroke locomotive type engines, the Navy has evaluated dual-fuel conversions operating on a compression ignition cycle, using up to 94% natural gas and 6% diesel pilot fuel. The Navy has conducted an evaluation and test program under the direction of Dr. Normnn L. Helgeson, at the Naval Facilities Engineering Service Center in Port Hueneme, California. Of the Navy`s many diesel engines, those installed in its MUSE (mobile utility support equipment) units for temporary electrical power were the first Navy off-road engines to be affected by emissions regulations. Most of the units are powered by the EMD 645 engine, and when burning diesel fuel do not meet the emission requirements in many areas of the country. This paper discusses the changes and results of the conversion and shakedown tests.

1996-10-01

420

Developing a standardized test procedure for hybrid vehicles: The challenge of the SAE HEV task force

Development drilling from Chevron-operated Platform Hermosa, located on OCS-P 0316 of the Point Arguello field, began on January 30, 1987. To date, seven development wells have been drilled in to the northwest-southeast-trending, doubly plunging anticlinal structure. The results from drilling have confirmed the presence of intense folding and fracturing in the targeted Monterey Formation. Over 700 ft of conventional core were recovered from the B-2 well in the lower Sisquoc and Monterey Formations. Analysis of the core material has yielded important information on lithologic variations and fracture patterns in the productive Monterey Formation. Initial results of core studies, DST data, and wireline studies indicate a correlation between rock type and fracturing. Fracture trends and directional permeability suggested by drill-stem testing may affect future drilling patterns in the field.

1988-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

Calculation of neutron and gamma-ray emission spectra produced by p +2''2'Al reactions

In 1992, the Society of Automotive Engineers (SAE) established a task force to develop a procedure for measuring electric energy consumption, all-electric range, fuel economy, and exhaust emissions for hybrid vehicles; the procedure will be submitted to regulatory agencies as representing the automotive industry`s recommendations. The draft procedure is currently being tested on hybrid vehicles. The University of Maryland`s parallel hybrid was tested in September 1994, and the University of California-Davis` parallel hybrid and the University of Illinois` series hybrid will be tested in November 1994 and January 1995, respectively. The procedure is being modified to incorporate any lessons learned, and the task force hopes to recommend the final procedure to the SAE by mid 1995.

1994-11-01

422

Beyond the tropics: forest structure in a temperate forest mapped plot

As a contribution to the US/Japan cooperative program in fusion neutronics, we have prepared a library of multigroup neutron cross sections, scattering matrices, and covariances (uncertainties and their correlations). This 74-group library, called COVFILS-2, is being used at Los Alamos and at the University of California at Los Angeles in the sensitivity and uncertainty analysis of the Li_2O integral experiment recently performed at the Fast Neutron Source (FNS) in Japan. Another intended use of this library is in the estimation of the uncertainty in key performance parameters (such as breeding ratio) of conceptual fusion reactors. The 14 materials included in the first version of COVFILS-2 are H, "6Li, "7Li, Be, C, N, O, Na, Al, Si, Cr, Fe, Ni, and Pb.

1985-01-01

423

British Library Electronic Table of Contents (United Kingdom)

Abstract Question: How do the diversity, size structure, and spatial pattern of woody species in a temperate (Mediterranean climate) forest compare to temperate and tropical forests? Location: Mixed evergreen coastal forest in the Santa Cruz Mountains, California, USA. Methods: We mapped, tagged, identified, and measured all woody stems (?1 cm diameter) in a 6-ha forest plot, following Center for Tropical Forest Science protocols. We compared patterns to those found in 14 tropical and 12 temperate forest plots. Results: The forest is dominated by Douglas-fir (Pseudotsuga menziesii) and three species of Fagaceae (Quercus agrifolia, Q. parvula var. shrevei, and Lithocarpus densiflorus), and includes 31 woody species and 8180 individuals. Much of the diversity was in small-diameter shrubs,...

2010-01-01

424

Atmospheric 222Rn measurements at San Nicolas Island during 1980. Memorandum report

A cost of energy comparison of single and multi cavity solar central receiver systems

The results of radon concentration measurements in the near surface air at San Nicolas Island, California, are presented for five different measurement sessions between May 1978 and July 1980. Emphasis is on the previously unreported results for January and July 1980. For six of eight days during the January session the measured radon concentration was greater than 40 picocuries per cm, corresponding to a continental air mass. Only the first day involved a maritime air mass with radon concentration less than about 6 picocuries per cm. In contrast to all the previous sessions, maritime air dominated the ten day session in July 1980, with radon concentrations generally less than about 5 picocuries per cm.

1981-10-13

425

1,800 Years of abrupt climate change, severe fire, and accelerated erosion, Sierra Nevada, California, USA

Variations in thermal energy costs of single module solar central receiver systems using one, two, three, and four aperture cavity receivers at a location corresponding to Barstow, California are investigated for nominal power ratings ranging from 100 MWt to 900 MWt. Also considered are the effects on energy costs of changes in plant latitude, and the energy cost impact of the replacement of the single module design with multiple connected modules producing the same thermal power. The results, obtained with the aid of the DELSOL2 computer program, indicate that solar central receiver plant energy costs are insensitive functions of power level, latitude, and configuration. No clear cost of energy advantage between single and multiple modules is seen.

1983-06-01

426

British Library Electronic Table of Contents (United Kingdom)

This paper provides both a detailed history of environmental change in the Sierra Nevada over the past 1,800?years and evidence for climate teleconnections between the Sierra Nevada and Greenland during the late Holocene. A review of Greenland ice core data suggests that the magnitudes of abrupt changes in temperature and precipitation increased beginning c. 3,700 and 3,000?years ago, respectively. Precipitation increased abruptly 1,300?years ago. Comparing paleotemperature data from Cirque Peak, CA with paleoprecipitation data from Pyramid Lake, NV suggests that hot temperatures occurred at the beginnings of most severe droughts in the Sierra Nevada over the past 1,800?years. Severe fires and erosion also occurred at Coburn Lake, CA at the beginning of all severe droughts in the Sierra Ne...

2011-01-01

427

Variability of indicator values for ozone production sensitivity: a model study in Switzerland and San Joaquin Valley (California)

Thermal performance of phase change wallboard for residential cooling application

The threshold values of indicator species and ratios delineating the transition between NO_x and VOC sensitivity of ozone formation are assumed to be universal by various investigators. However, our previous studies suggested that threshold values might vary according to the locations and conditions. In this study, threshold values derived from various model simulations at two different locations (the area of Switzerland by UAM Model and San Joaquin Valley of Central California by SAQM Model) are examined using a new approach for defining NO_x and VOC sensitive regimes. Possible definitions for the distinction of NO_x and VOC sensitive ozone production regimes are given. The dependence of the threshold values for indicators and indicator ratios such as NO_y, O_3/NO_z, HCHO/NO_y, and H_2O_2/HNO_3 on the definition of NO_x and VOC sensitivity is discussed. Then the variations of threshold values under low emission conditions and in two different days are examined in ...

428

The value of distributed generation: The PVUSA grid-support project serving Kerman Substation. Interim report, April 1994

Cooling of residential California buildings contributes significantly to electrical consumption and peak power demand mainly due to very poor load factors in milder climates. Thermal mass can be utilized to reduce the peak-power demand, downsize the cooling systems, and/or switch to low-energy cooling sources. Large thermal storage devices have been used in the past to overcome the shortcomings of alternative cooling sources, or to avoid high demand charges. The manufacturing of phase change material (PCM) implemented in gypsum board, plaster or other wall-covering material, would permit the thermal storage to become part of the building structure. PCMs have two important advantages as storage media: they can offer an order-of-magnitude increase in thermal storage capacity, and their discharge is almost isothermal. This allows the storage of high amounts of energy without significantly changing the temperature of the room envelope. As heat storage takes place ...

1997-04-01

429

Naval Petroleum and Oil Shale Reserves. Annual report of operations, fiscal year 1983

A common practice of electric utilities experiencing transmission and distribution (T and D) system overloads is to expand the substation, add lines, or upgrade equipment, all of which are capital intensive options. In 1988, it was hypothesized that strategically sited photovoltaics (PV) could benefit parts of T and D systems near or at overloaded conditions. An evaluation methodology was developed and applied to a test case (Kerman Substation near Fresno, California). Analytical results suggested that the value of PV to the T and D system could substantially exceed its energy and generation capacity value. The importance of this finding indicated the need for empirical validation. This led to the construction of a 0.5 MW PV demonstration plant by Pacific Gas and Electric Company (PG and E) at Kerman, California as part of the PVUSA (PV for Utility Scale Applications) project. PVUSA is a national public-private partnership that is assessing and ...

1994-07-01

430

NATURAL GAS VARIABILITY IN CALIFORNIA: ENVIRONMENTAL IMPACTS AND DEVICE PERFORMANCE EXPERIMENTAL EVALUATION OF POLLUTANT EMISSIONS FROM RESIDENTIAL APPLIANCES

Naval Petroleum Reserve No. 1 (NPR-1) in California and Naval Petroleum Reserve No. 3 (NPR-3) in Wyoming continued to be operated at their maximum efficient rates of production during FY 1983. The Government-owned portion of Naval Petroleum Reserve No. 2 in California continued to be leased to private operators as it has been for over 50 years, with the Government receiving a royalty share of production from the leases. All of the Government's share of crude oil produced at the Petroleum Reserves during FY 1983 was sold to the Department of Defense, while natural gas and natural gas liquids were sold competitively on the open market. FY 1983 revenues from the three Naval Petroleum Reserves totaled over $1.5 billion in general receipts and Windfall Profit Taxes. Program expenditures totaled approximately $220 million. The drilling of new wells continued to be an important factor in maintaining the production of NPR-1 and NPR-3 at ...

1983-01-01

431

Development of a dedicated ethanol ultra-low emission vehicle (ULEV) system design

The effect of liquefied natural gas on pollutant emissions was evaluated experimentally with used and new appliances in the laboratory and with appliances installed in residences, targeting information gaps from previous studies. Burner selection targeted available technologies that are projected to comprise the majority of installed appliances over the next decade. Experiments were conducted on 13 cooktop sets, 12 ovens, 5 broiler burners, 5 storage water heaters, 4 forced air furnaces, 1 wall furnace, and 6 tankless water heaters. Air-free concentrations and fuel-based emission factors were determined for carbon monoxide, nitrogen oxides, nitrogen dioxide, and the number of (predominantly ultrafine) particles over complete burns?including transient effects (device warm-up and intermittent firing of burners) following ignition--and during more stable end-of-burn conditions. Formaldehyde was measured over multi-burn cycles. The baseline fuel was Northern California ...

2009-12-01

432

Air quality constraints to statewide power plant siting. Final staff report

The objective of this 3.5 year project is to develop a commercially competitive vehicle powered by ethanol (or ethanol blend) that can meet California`s ultra-low emission vehicle (ULEV) standards and equivalent corporate average fuel economy (CAFE) energy efficiency for a light-duty passenger car application. The definition of commercially competitive is independent of fuel cost, but does include technical requirements for competitive power, performance, refueling times, vehicle range, driveability, fuel handling safety, and overall emissions performance. This report summarizes a system design study completed after six months of effort on this project. The design study resulted in recommendations for ethanol-fuel blends that shall be tested for engine low-temperature cold-start performance and other criteria. The study also describes three changes to the engine, and two other changes to the vehicle to improve low-temperature starting, efficiency, and emissions. ...

1995-02-01

433

A zinc-air battery and flywheel zero emission vehicle

The object of this study was to identify those areas in California where synthetic fuel-fired power plants could be sited in the 1990 time frame, from an air quality perspective. The synfuel-fired power plants considered in this new study were 500 Mw methanol-fired combined cycle (MFCC) and 500 Mw integrated gasifier combined-cycle (IGCC) units. For comparison purposes, 500 Mw direct coal-fired boilers and 500 Mw natural gas-fired combined-cycle units were also considered. Staff did not attempt to locate plants at any specific sites, but relied primarily upon a regional countywide analysis. The study provides an approximation, for planning purposes, of a reasonable limit of the state's power plant siting capacity, given the plant types and sizes, conditions, and assumptions specified. The study shows that local emission limitations often preclude certain types of power plants (particularly direct-fired coal plants) even when they are equipped with Best ...

1980-11-01

434

Studies on metabolism of directly labeled {sup 99}MTc-antibody in mice

In response to the 1990 Clean Air Act, the California Air Resources Board (CARB) developed a compliance plan known as the Low Emission Vehicle Program. An integral part of that program was a sales mandate to the top seven automobile manufacturers requiring the percentage of Zero Emission Vehicles (ZEVs) sold in California to be 2% in 1998, 5% in 2001 and 10% by 2003. Currently available ZEV technology will probably not meet customer demand for range and moderate cost. A potential option to meet the CARB mandate is to use two Lawrence Livermore National Laboratory (LLNL) technologies, namely, zinc-air refuelable batteries (ZARBs) and electromechanical batteries (EMBs, i. e., flywheels) to develop a ZEV with a 384 kilometer (240 mile) urban range. This vehicle uses a 40 kW, 70 kWh ZARB for energy storage combined with a 102 kW, 0.5 kWh EMB for power peaking. These technologies are sufficiently near-term and cost-effective to plausibly be in ...

1995-10-03

435

Role of the Yersinia pestis Ail Protein in Preventing a Protective Polymorphonuclear Leukocyte Response During Bubonic Plague.

The elucidation on the metabolic products of the {sup 99}mTc-antibody conjugates may provide insights and approaches that would reduce the undesirable deposition of radioactive species in normal tissue. In this investigation, the radiolabeled species in blood, urine, bile and extracts of liver and kidney obtained at different times after the injection of a model antibody, {sup 99}mTc, into mice were analyzed with various chromatographic methods. Ninety-nine to 100% of the radioactivity in serum was associated with intact Mab 170. The radioactivity in liver homogenate extract was strictly protein-bound to either intact Mab or low molecular weight species (LMW). In kidney extracts, the majority of the radioactivity was protein bound {sup 99}mTc, with less than 8% of the activity being non- protein bound . Multiple {sup 99}mTc -containing protein and non-protein species were found in urine and bile. Evidence supporting the presence of {sup 99}mTc-cysteine and {sup ...

1996-12-01

436

Regulatory role of neuron-restrictive silencing factor in expression of TRPC1

The ability of Yersinia pestis to forestall the mammalian innate immune response is a fundamental aspect of plague pathogenesis. In this study, we examined the effect of Ail, a 17-kDa outer membrane protein that protects Y. pestis against complement-mediated lysis, on bubonic plague pathogenesis in mice and rats. The Y. pestis ail mutant was attenuated for virulence in both rodent models. The attenuation was greater in rats than in mice, which correlates with the ability of normal rat serum, but not mouse serum, to kill ail-negative Y. pestis in vitro. Intradermal infection with the ail mutant resulted in an atypical, subacute form of bubonic plague associated with extensive recruitment of polymorphonuclear leukocytes (PMN or neutrophils) to the site of infection in the draining lymph node and the formation of large purulent abscesses that contained the bacteria. Systemic spread and mortality were greatly attenuated, however, and a productive ...

2011-10-01

437

Protective efficiency of dendrosomes as novel nano-sized adjuvants for DNA vaccination against birch pollen allergy

Neuron-restrictive silencer factor (NRSF) binds its consensus element to repress the transcription of various genes. The dominant-negative form (dnNRSF) has a hypertrophic effect on cardiogenesis through an unidentified mechanism. We examined the involvement of transient receptor potential (TRP) channel proteins, using transgenic mice overexpressing dnNRSF (dnNRSF mice). Electrophoretic mobility-shift assays revealed an interaction between NRSF and a neuron-restrictive silencer element-like sequence in intron 4 of TRPC1 genomic DNA. According to RT-PCR and Western analyses, TRPC1 was up-regulated in dnNRSF mouse heart. Transient overexpression of TRPC1 in HEK 293T cells increased the activity of the nuclear factor in activated T cells (NFAT) promoter and stimulated store-operated Ca"2"+ channel (SOCC)-mediated Ca"2"+ entry. Transfection of TRPC1 into primary cardiomyocytes increased NFAT activity, indicating a major role for TRPC1 in NFAT ...

2006-12-22

438

British Library Electronic Table of Contents (United Kingdom)

We evaluated the use of a novel gene porter (Den123-a nontoxic self-assembled dendritic spheroidal nanoparticle made of biodegradable monomers), aiming to enhance and improve the desired immune response in protection from allergy. Footpad DNA immunization in Balb/c mice was done three times using the Bet v 1a gene with or without Den123 with 2-week intervals followed by sensitization with rBetv1 (5mg) in alum twice in a weekly interval. Different doses of pCMV-Betv1 were used (10mg and 100mg). The protective role of different formulations was evaluated by measuring the IgG1, IgG2a and IgE antibody production, cytokine release of isolated splenocytes and b-hexosaminidase release from the RBL cells. Higher and increasing ratios of IgG2a/IgG1 were seen in mice which received plasmids in combi...

2006-01-01

439

Multistep process of neoplastic transformation of normal human fibroblasts by 60Co gamma rays and Harvey sarcoma viruses

Lead and calcium distributions in blood, plasma, and milk of the lactating mouse

As reported previously (Namba et al., 1985), normal human fibroblasts were transformed by 60Co gamma-ray irradiation into immortal cells with abnormal karyotypes. These transformed cells (KMST-6), however, showed a low cloning efficiency in soft agar and no transplantability. However, upon treatment with Harvey murine sarcoma virus (Ha-MSV), the cells acquired elevated clonability in soft agar and transplantability in nude mice. Ha-MSV alone, however, did not convert normal human fibroblasts into either immortal or tumorigenic cells. The Ha-MSV-transformed KMST-6 cells showed an enhanced expression of the ras oncogene, but normal and 60Co gamma-ray-transformed cells did not. Our current data suggest that gamma rays worked against normal human cells as an initiator, giving rise to chromosome aberrations and immortality, and that Ha-MSV, probably through its ras oncogene, played a role in the progression of the malignant cell population to a more malignant one ...

1986-03-15

440

Final report of the specific research. Investigations on the analysis of bio-protective factors against radiation. 1998-2000 FY (Research Group of NIRS)

Although it has been established that lead is transferred in milk from mother to suckling offspring, the physiological processes and parameters involved are not well understood. Single i.v. doses (0.2 mg/kg) or p.o. doses (2 mg/kg) of radiolabeled lead were administered to lactating and nonlactating female mice, and lead concentrations in blood, plasma, and milk were determined during a 21-day period. Large differences in lead elimination were observed between lactating and nonlactation mice. A significant fraction (25%) of the initial maternal dose (absorbed dose) was transferred to the suckling pups. The ratio of lead concentration in milk to lead concentration in plasma was found to be nearly constant over time. However, the milk-to-blood concentration ratios decreased during the same period. Furthermore, the concentration of lead in milk exceeded the plasma concentration by a factor of approximately 25, indicating that there is a ...

1980-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Evaluation of the radioprotective effect of turmeric extract and vitamin E in mice exposed to therapeutic dose of radioiodine

This report concerns investigations in the title conducted by 8 groups of National Institute of Radiological Sciences (NIRS) during the period of 1998-2000. The groups are for investigation of: Effects of p53 tumor suppressor gene in radiation-induced leukemia, Role of atm-gene in dose rate effect of ionizing radiation, Function of DNA-dependent protein kinase catalytic subunit (DNA-PK{sub cs}), Functional complementation of radiation-sensitive mutant M10 cell line by human XRCC4 cDNA expression, Role of radiation-induced apoptosis in digital defects in embryonic mice, Functional analysis of S-phase specific novel nuclear protein NP95 by gene targeting, Role of chemokine in T cell development and lymphomagenesis, and establishment of production techniques of gene-modified mice using embryonic stem cells for genetic analysis of radiation-sensitive genes. The groups describe summaries of their studies and published original articles are also ...

2002-03-01

442

Effects of microwaves on the colony-forming capacity of haemopoietic stem cells in mice

The aim of this study was to evaluate the radioprotective effect of turmeric extract (40 mg/kg body weight) and vitamin E (#alpha# - tocopherol acetate, 400 IU/kg body weight) supplementation on lipid peroxidation, reduced glutathione and antioxidant defense enzymes in various organs like liver, kidney and salivary glands at 24 h in adult Swiss mice. "1"3"1Iodine exposure significantly increased lipid peroxidation in kidney and salivary glands in comparison to control animals. Pre supplementation with turmeric extract for 15 days showed significant lowering of lipid peroxidation in kidney. On the other hand vitamin E pre supplementation showed marked reduction in lipid peroxidation in salivary glands. Reduced glutathione levels decreased significantly in liver after radiation exposure. However, pre supplementation with turmeric extract and vitamin E did not improve glutathione levels in liver. In conclusion we have observed differential radioprotective effect of ...

2008-10-01

443

Effect of dose on lead retention and distribution in suckling and adult female mice

A suspension of bone marrow cells from femurs of female (CBA . C57B1)F1 mice was exposed to 2450 MHz CW microwaves in a specially designed waveguide exposure system. The temperature of the suspension rose, during exposure to microwaves, from 20/sup 0/C to 45/sup 0/C, and at an interval within 20/sup 0/C to 45/sup 0/C the number of haemopoietic stem cells (CFUs) was determined by the spleen exocolony method. The time of exposure of bone marrow cells to each temperature studied was 20 s. Control suspensions of bone marrow cells were exposed to a water bath temperature. There were no significant effects of the CFUs with the water bath temperature, while after exposure to microwaves the number of spleen colonies was elevated with a nadir at the temperature of 37/sup 0/C. With a microwave-induced increase of the temperature above 41/sup 0/C the number of CFUs in the bone marrow suspension decreased. The increase in the number of colonies was related to the rise in the ...

1987-01-01

444

Development of functional foods for radiation workers

Single doses of lead (trace to 445 mg/kg) were administered per os to suckling and adult mice. Both groups exhibited dose-independent lead retention when doses of 4 to 445 mg/kg were administered. However, developmental differences in the fraction of initial dose (FID) retained were evident for all doses administered. A much larger FID was retained in both age groups following administration of carrier-free /sup 203/Pb. The results are consistent with a mechanism of gastrointestinal lead absorption comprising two or more processes. Developmental differences were also observed in organ lead concentration relative to whole body concentration for kidneys, skull and brain 6 days following lead administration. Lead retentions (relative to whole body retention) in brain and in bone were linearly related to dose of lead administered in both suckling and adult age groups. Though uptake of lead into brain and into femur was observed to be directly related to dose over a ...

1980-01-01

445

Artesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacillin

In searching modulators of immunity and hematopoiesis among natural products, being used as foods, six herbs exhibited lymphocyte proliferation in vitro, and six exhibited augmentation of hematopoietic cell growth. The combined treatments showed synergistic effects of lymphocyte proliferation and of hematopoietic cell growth. On the other hand, we found four effective oriental medicinal prescriptions, used as energy tonic or blood-building decoctions, for survival and regeneration of hematopoietic cells and for protection of stem cells of intestinal crypt in irradiated mice. On the basis of these results, extracts from combinations of herbs were made in expectation of higher effects in the three respects. In immuno modulation activity by the two combinations of herbs was confirmed in mice. In culture of bone narrow cells, growth improvement of non-adherent precursor and induction of cytokine expression by herb mixture extracts were observed. In ...

2000-03-01

446

British Library Electronic Table of Contents (United Kingdom)

Sepsis induced by methicillin-resistant Staphylococcus aureus (MRSA) has worse outcome because of multiresistance to a large group of antibiotics, which may lead to death from septic shock. In the present study, we firstly found that artesunate in combination with oxacillin was capable of protecting mice challenged with live MRSA WHO-2 (WHO-2) and the protection was related to the reduced TNF-a and IL-6 levels and decreased bacterial load. Based on above results, artesunate was further investigated from two aspects in vitro, anti-inflammation effect and antibacterial enhancement effect on antibiotics. Artesunate not only inhibited TNF-a and IL-6 release but also inhibited mRNA and protein expressions of TLR2 and Nod2, two important receptors, in murine peritoneal macrophages stimulated wit...

2011-01-01

447

Analgesic activity of the aqueous fraction from the ethanolic extract of Chrysanthemum indicum in mice.

A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in mice

The aqueous fraction (AF) of an ethanolic extract from Chrysanthemum indicum was evaluated for analgesic activity in mice using chemical and thermal models of nociception. Given orally, AF at doses of 300 and 600 mg/kg produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid, subplantar formalin/capsaicin injections and on thermal nociception in the tail-flick test and in the hot plate test. In the pentobarbital sodium-induced sleeping time test and the open-field test, AF neither significantly enhanced the pentobarbital sodium-induced sleeping time nor impaired the motor performance, indicating that the observed analgesic activity was unlikely due to sedation or motor abnormality. In a measurement of core body temperature, AF did not affect temperature within 80 min. Moreover, the effective dose (600 mg/kg) also showed no toxicity within 7 days. These results suggested further that AF produced analgesic activity possibly ...

2011-07-01

448

British Library Electronic Table of Contents (United Kingdom)

The identification of genes influencing sensitivity to stimulants and opioids is important for determining their mechanism of action and may provide fundamental insights into the genetics of drug abuse. We used a panel of C57BL/6J (B6; recipient)x A/J (donor) chromosome substitution strains (CSSs) to identify quantitative trait loci (QTL) for both open field activity and sensitivity to the locomotor stimulant response to methamphetamine (MA). Mice were injected with saline (days 1 and 2) and MA (day 3; 2 mg/kg i.p.). We analyzed the total distance traveled in the open field for 30 min following each injection. CSS-8, -11 and -16 showed reduced MA-induced locomotor activity relative to B6, whereas CSS-10 and -12 showed increased MA-induced locomotor activity. Further analysis focused on CSS...

2009-01-01

449

The "9"9Tc"m-labelling of diamino-dithiol complexes as brain imaging agents and preliminary biodistribution

Radioprotective activity in some medicinal herbs

Six kinds of diamino-dithiol compounds are labelled with "9"9Tc"m by ligands exchange reaction. Their ligands exchange percentage is over 95%. The biodistribution of one of these compounds in mice shows 0.88% brain uptake after two minutes and 0.28% after 15 minutes respectively. Although the brain uptake is lower for this compound, it has longer retention in brain. So, the experiment results are valuable to the design of new brain imaging agent in the future.

450

Pathogenic and nonpathogenic Acanthamoeba spp. in thermally polluted discharges and surface waters

Water-soluble, ethanol-insoluble extracts prepared from several medicinal herbs of the Araliaceae and other families were tested for their radioprotective activity by either measuring 30 days survival rates (a commonly applied method) or counting the thrombocytes 14 days after irradiation (an improved method) in mice. The extracts were i.p. injected once within 4 min after the whole body X-ray irradiation. Of 12 materials examined, Aralia elata, Angelica acutiloba and Morus bombysis seemed to be good starting materials for preparing radioprotective substance(s) because of their relatively high specific activity and high yields of the extracts. (author).

1993-09-01

451

Isolation and amino acid sequence of a short-chain neurotoxin from an Australian elapid snake, Pseudechis australis.

During spring and autumn, the total number of amoebae and the number of acanthamoeba species able to grow at 37 degrees C were determined in six thermally polluted factory discharges and the surrounding surface waters. The isolated Acanthamoeba strains were studied for growth in axenic medium, cytopathic effect in Vito cell cultures, and virulence in mice. Although more amoebae were isolated in autumn, the number of Acanthamoeba species was lower than in spring, when the percent of pathogenic strains among the isolates was highest. Higher concentrations of amoebae were found in warm discharges, and more virulent strains occurred in thermal discharges than in surface waters.

452

Anticonvulsant properties of selected pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates.

A short-chain neurotoxin Pseudechis australis a (toxin Pa a) was isolated from the venom of an Australian elapid snake Pseudechis australis (king brown snake) by sequential chromatography on CM-cellulose, Sephadex G-50 and CM-cellulose columns. Toxin Pa a has an LD50 (intravenous) value of 76 micrograms/kg body wt. in mice and consists of 62 amino acid residues. The amino acid sequence of Pa a shows considerable homology with those of short-chain neurotoxins of elapid snakes, especially of true sea snakes. PMID:4091794

1985-12-01

453

Animal experiments on the biokinetics of astatide and astate-(I)-complex compounds

A series of pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates was tested for anticonvulsant activity in mice. Eleven of the 15 compounds possessed anticonvulsant activity against pentylenetetrazol-induced convulsions. One compound afforded more anticonvulsant protection against pentylenetetrazol than did trimethadione (67 and 50%, respectively). A suspension of this compound was found to be as effective as a solution in producing anticonvulsant activity. The results suggest that the nitrile analogs were more potent compared to the carbamyl analog due to higher lipid solubility. PMID:7373552

1980-04-01

454

[mRNA level and cytochrome P450 1A activity in the liver of C57BL mice induced by various xenobiotics].

The radiation properties of the #alpha# emitter "2"1"1At are in favor of its application malignant tumor therapy. As a basis for further investigations the biokinetics of At"-, At x H_2O, At I_2"-, and [At(thio)_2]"+ were determined after i.v. injection into healthy and tumor-bearing mice. The estimation of the ion mobility of the carrier-free compounds allowed the use of uniquely characterized initial compounds. The organ distribution of all species examined was similar to the distribution of astatide. Accumulation was found in the thyroid and other inner organs. (author).

455

Uptake of /sup 67/Ga in the lung of mice during bleomycin treatment

The rate of hepatic cytochrome P450 Cypla1 and Cyp1a2 induction was investigated in C57BL male mice during induction with o-aminoazotoluene (OAT), benzo[a]pyrene (BP) and 1,4-dihydroxyanthraquinone (AQ). The Cypla1 mPNA level determined by quantitative RT-competitive PCR increased more than three orders of magnitude during induction with OAT and BP compared with untreated animals and remained unchanged during induction with AQ. The Cypla2 mRNA level was only 8.5, 18.7 and 1.9 times higher during induction with OAT, BP and AQ respectively than in untreated mice. At the same time 7-Ethoxyresorufin-O-deethylase (EROD) and 7-Methoxyresorufin-O-demethylase (MROD) activities of Cypla were also investigated in liver. The increase of Cypla1 mRNA level correlated with the increase of EROD activity. This suggests involvement of the transcriptional mechanism of the inducibility of this enzyme. In the case of Cypla2 there was insignificant increase of its ...

456

Species comparison of acute inhalation toxicity of ozone and phosgene

Changes of /sup 67/Ga uptake in the lungs and changes of components of the so-called ground substance of the lung connective tissues of mice were followed for 7 weeks after the start of bleomycin (BLM) administration (20 mg/kg body weight IP, twice weekly for 5 weeks; this treatment induced fibrosis of the lung). /sup 67/Ga uptake of the lung was elevated at 1 week, and reached a maximum at 5 weeks (3.00+-0.11% dose/g lung), and then decreased slightly at 7 weeks. The uronic acid content in the 1.2 M NaCl-soluble fraction, which contained predominantly heparan sulfate (HS), was increased at 1 week, peaked at 3 weeks, and then remained unchanged up to 7 weeks. This pattern was similar to that of /sup 67/Ca acumulation in the lungs. The uronic acid content of the 0.4 M NaCl-fraction, which contained predominantly hyaluronic acid (HA), was decreased at 1 week, but increased to a maximum at 3 weeks, then decreased to about the initial level at 5 weeks and decreased ...

1984-02-01

457

Sida rhomboidea. Roxb Leaf Extract Down-Regulates Expression of PPAR?2 and Leptin Genes in High Fat Diet Fed C57BL/6J Mice and Retards in Vitro 3T3L1 Pre-Adipocyte Differentiation.

A comparison of the concentration-response effects of inhaled ozone (O/sub 3/) and phosgene (COCl/sub 2/) in different species of laboratory animals was made in order to better understand the influence of the choice of species in inhalation toxicity studies. The effect of 4-h exposures to ozone at concentrations of 0.2, 0.5, 1.0, and 2.0 ppm, and to COCl/sub 2/ and 0.1, 0.2, 0.5, and 1.0 ppm was determined in rabbits, guinea pigs, rats, hamsters, and mice. Lavage fluid protein (LFP) accumulation 18-20 h after exposure was used as the indicator of O3- and COCl/sub 2/-induced pulmonary edema. All species had similar basal levels of LFP (250-350 mg/ml) when a volume of saline that approximated the total lung capacity was used to lavage the collapsed lungs. Ozone effects were most marked in guinea pigs, which showed significant effects at 0.2 ppm and above. Mice, hamsters, and rats showed effects at 1.0 ppm O3 and above, while rabbits responded ...

1986-01-01

458

Preliminary study of metabolic radiotherapy with {sup 188}Re via small animal imaging

Sida rhomboidea. Roxb leaf extract (SRLE) is being used by the populace of North-East India to alleviate symptoms of diabetes and obesity. We have previously reported its hypolipidemic and anti-diabetic properties. In this study, we report the effect of SRLE on (i) in vivo modulation of genes controlling high fat diet (HFD) induced obesity and (ii) in vitro 3T3L1 pre-adipocyte differentiation and leptin release. Supplementation with SRLE significantly prevented HFD induced increment in bodyweight, plasma lipids and leptin, visceral adiposity and adipocyte hypertrophy. Also, SRLE supplementation reduced food intake, down regulated PPAR?2, SREBP1c, FAS and LEP expressions and up-regulated CPT-1 in epididymal adipose tissue compared to obese mice. In vitro adipogenesis of 3T3L1 pre-adipocytes was significantly retarded in the presence of SRLE extract. Also decreased triglyceride accumulation, leptin release and glyceraldehyde-3-Phosphate dehydrogenase activity along ...

2011-07-19

459

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice.

{sup 188}Re is a {beta}{sup -} (Emax=2.12 MeV) and {gamma} (155 keV) emitter. Since its chemistry is similar to that of the largely employed tracer, {sup 99m}Tc, molecules of hyaluronic acid (HA) have been labelled with {sup 188}Re to produce a target specific radiopharmaceutical. The radiolabeled compound, i.v. injected in healthy mice, is able to accumulate into the liver after a few minutes. To study the effect of metabolic radiotherapy in mice, we have built a small gamma camera based on a matrix of YAP:Ce crystals, with 0.6x0.6x10 mm{sup 3} pixels, read out by a R2486 Hamamatsu PSPMT. A high-sensitivity 20 mm thick lead parallel-hole collimator, with hole diameter 1.5 mm and septa of 0.18 mm, is placed in front of the YAP matrix. Preliminary results obtained with various phantoms containing a solution of {sup 188}Re and with C57 black mice injected with the {sup 188}Re-HA solution are presented. To increase the space ...

2006-01-15

460

Murine antibody response to oral infection with live aroA recombinant Salmonella dublin vaccine strains expressing filamentous hemagglutinin antigen from Bordetella pertussis.

Streptococcus pneumoniae colonizes the mucosal surface of the human upper respiratory tract. A colonization event is gradually cleared through phagocytosis by monocytes/macrophages that are recruited to the airway lumen. Here, we sought to define the bacterial and host factors that promote monocyte/macrophage influx and S. pneumoniae clearance using intranasal bacterial challenge in mice. We found that the recruitment of monocytes/macrophages required their expression of the chemokine receptor CCR2 and correlated with expression of the CCR2 ligand CCL2. Production of CCL2 and monocyte/macrophage recruitment were deficient in mice lacking digestion of peptidoglycan by lysozyme (LysM) and cytosolic sensing of the products of digestion by Nod2. Ex vivo macrophages produced CCL2 following bacterial uptake, digestion by LysM, and sensing of peptidoglycan by Nod2. Sensing of digested peptidoglycan by Nod2 also required the pore-forming toxin ...

2011-08-15

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Impaired neonatal survival of pro-opiomelanocortin null mutants.

Two plasmids which express either nearly intact or truncated filamentous hemagglutinin (FHA) from Bordetella pertussis and which are marked with a tetracycline resistance (Tcr) gene were transformed into Salmonella dublin SL1438, an aroA deletion mutant intended for use as an attenuated oral vaccine against salmonellosis. These S. dublin recombinants, when fed to mice, induced serum immunoglobulin, immunoglobulin M (IgM), and sometimes IgA antibody responses to FHA and S. dublin. In addition, IgA antibodies against FHA were found in gut wash fluids. S. dublin carrying pDB2300, a multicopy plasmid encoding truncated FHA protein, induced a better antibody response than did S. dublin carrying pDB2000, a low-copy-number plasmid encoding full-sized FHA. Administration of tetracycline to mice enhanced the stability of recombinant plasmids, and tetracycline-treated mice developed higher anti-FHA titers. Although neither strain ...

1990-08-01

462

Heat Shock Protein 27-Targeted Heptapeptide of the PKC? Catalytic V5 Region Sensitizes Tumors With Radio- and Chemoresistance

Intercrosses of heterozygous pro-opiomelanocortin (POMC) mice result in homozygous null progeny at lower frequencies than expected. Genotyping offspring at pre-, peri-, and postnatal stages revealed that over half of homozygous null mutants die in the early postnatal stages. To investigate the reasons for this early postnatal lethality, we analyzed in detail different parameters in the initial hours after birth. POMC null mutants born to heterozygous dams presented at birth with corticosterone levels no different from wildtype littermates, were euglycemic, and had normal liver glycogen stores. However, already 30 min after birth corticosterone levels dropped by 80% and were undetectable thereafter, while corticosterone levels in wildtype animals increased during postnatal hours. Circulating adrenaline was almost below detection 1h after birth. Blood glucose levels fell sharply in all genotypes within 30 min after birth; however, wildtype and heterozygous pups ...

2010-12-22

463

Functional Characterization of Melanocyte Stem Cells in Hair Follicles.

Purpose: Previous data suggest that the PKC? catalytic V5 (PKC?-V5) heptapeptide (HEPT) (FEQFLDI) binds HSP27 and blocks HSP27-mediated radio- or chemoresistance. Here we investigated further the in vivo function of the PKC?-V5 HEPT. Methods and Materials: Labeling of HEPT with Cy5.5 or fluorescein isothiocyanate was performed to evaluate in vitro or in vivo distribution of HEPT. A clonogenic survival assay, flow cytometry, and Western blotting of cleaved caspase-3 were performed to determine in vitro sensitization effects of HEPT plus ionizing radiation (IR) versus IR alone or those of HEPT plus cisplatin(Cis) versus Cis alone. A nude mouse xenografting system was also applied to detect in vivo sensitizing effects of HEPT. Results: HEPT efficiently bound to HSP27 and showed sensitization after combined treatment with IR versus treatment with Cis alone in NCI-H1299 lung carcinoma cells, with higher HSP27 expression, which was similar to that of combined treatment with IR or with Cis ...

2011-05-01

464

Friend Spleen Focus-Forming Virus Activates the Tyrosine Kinase sf-Stk and the Transcription Factor PU.1 to Cause a Multi-Stage Erythroleukemia in Mice.

In mice, coat pigmentation requires a stem cell (SC) system in which the survival, proliferation, and differentiation of melanocytes (MCs) are regulated by microenvironments in hair follicles (HFs). In vitro systems are required to analyze the behavior of single melanocyte stem cells (MCSCs) and their potential to form SC systems in vivo. We describe here an experimental system for the isolation, self-renewal, and differentiation of MCSCs, as well as an in vivo reconstitution assay for assessing their potential. Using Dct(tm1(Cre)Bee)/CAG-CAT-GFP mice, we show that, in the presence of stem cell factor and basic fibroblast growth factor and the XB2 feeder cell line, purified MCSCs can undergo clonogenic proliferation, resulting in c-Kit(low) side scatter(low) cells. In culture, these cells maintain their capacity to differentiate and reconstitute an MCSC system in HFs. As these cells are present in the upper part of the HF near the bulge region, ...

2011-07-14

465

Effects of amifostine on radiation-induced apoptosis in mouse ovary

HEMATOLOGICAL MALIGNANCIES IN HUMANS TYPICALLY INVOLVE TWO TYPES OF GENETIC CHANGES: those that promote hematopoietic cell proliferation and survival (often the result of activation of tyrosine kinases) and those that impair hematopoietic cell differentiation (often the result of changes in transcription factors). The multi-stage erythroleukemia induced in mice by Friend spleen focus-forming virus (SFFV) is an excellent animal model for studying the molecular basis for both of these changes. Significant progress has been made in understanding the molecular basis for the multi-stage erythroleukemia induced by Friend SFFV. In the first stage of leukemia, the envelope protein encoded by SFFV interacts with and activates the erythropoietin (Epo) receptor and the receptor tyrosine kinase sf-Stk in erythroid cells, causing their Epo-independent proliferation, differentiation and survival. In the second stage, SFFV integration into the Sfpi1 locus activates the myeloid ...

2010-10-11

466

Diagnostic and therapeutic evaluation of "1"1"1In-vinorelbine-liposomes in a human colorectal carcinoma HT-29/luc-bearing animal model

The present study was designed to assess the radioprotective effects of amifostine on ovarian follicles. Three week-old female mice with or without pretreatment of amifostine were irradiated with 6.42 Gy of #gamma# -ray. Ovaries were collected 0 and 6h after irradiation. DNA fragmentation pattern and expression of genes and activity of proteins related with apoptosis were investigated by means of RT-PCR and Western blot. Proliferation of granulosa cells was reduced and incidence rate of follicular atresia was increased in ovarian follicles in #gamma# -ray irradiated mice compared to those in control or amifostine-treated group. DNA fragmentation was increased in time-dependent manner in granulosa cells of all irradiated groups. However, no difference between amifostine pre-treated group and irradiated groups was found and the expression of p53 as tumor suppressor gene and Bax as one of pro-apoptotic Bcl-2 family was increased in irradiated ...

2002-10-20

467

Cytogenetic effects of protracted gamma exposures from conception of male mice

Colorectal carcinoma is a highly prevalent and common cause of cancer in Taiwan. There is still no available cure for this malignant disease. To address this issue, we applied the multimodality of molecular imaging to explore the efficacy of diagnostic and therapeutic nanoradiopharmaceuticals in an animal model of human colorectal adenocarcinoma [colorectal cancer (CRC)] that stably expresses luciferase (luc) as a reporter. In this study, an in vivo therapeutic efficacy evaluation of dual-nanoliposome (100 nm in diameter) encaged vinorelbine (VNB) and "1"1"1In-oxine on HT-29/luc mouse xenografts was carried out. HT-29/luc tumor cells were transplanted subcutaneously into male SCID mice. Multimodality of molecular imaging approaches including bioluminescence imaging (BLI), gamma scintigraphy, whole-body autoradiography (WBAR) and in vivo tumor growth tracing, histopathology and biochemistry/hematology analyses were applied on xenografted SCID ...

2008-07-01

468

Biokinetic and dosimetric studies of {sup 188}Re-hyaluronic acid: a new radiopharmaceutical for treatment of hepatocellular carcinoma

In order to gain an overall picture of the genetic effects of an increased level of background radiation it is necessary to study the results of protracted exposures to embryonic and immature germ-cell stages as well as to stages found in the mature organism. For this purpose, litters produced by female mice, kept in a 10 or 20 rad/day /sup 60/Co ..gamma..-irradiation field, were kept in the same fields from conception until about 60 days later, having absorbed doses of 526 and 1078 rad respectively. Tests on exposed female offspring showed them to be sterile. Eight weeks after removal from the gamma field, mean testis masses of males in the 20 rad/day series were only half normal but those receiving 10 rad/day were little affected. Frequencies of translocations in spermatocytes at diakinesis/metaphase I were only slightly increased in the exposed series, differences not being significant. Estimated rates of translocation induction were around 5 x 10sup(-6) per ...

1982-01-01

469

Binding Affinity of Re(CO)_3 Cl(EPBI) for A#beta#_(_1_#approx#_4_0_) Aggregates and Evaluation of ["9"9Tc"m(CO)_3]"+-EPBI

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has very limited therapeutic options. Recently, it has been found that hyaluronic acid (HA) shows selective binding to CD44 receptors expressed in most cancer histotypes. Since the trend in cancer treatment is the use of targeted radionuclide therapy, the aim of this research was to label HA with rhenium-188 and to evaluate its potential use as a hepatocarcinoma therapeutic radiopharmaceutical. Methods: {sup 188}Re-HA was prepared by a direct labelling method to produce a ReO(O-COO){sub 2}-type coordination complex. {sup 188}Re-HA protein binding and its stability in saline, phosphate buffer, human serum and cysteine solutions were determined. Biokinetic and dosimetric data were estimated in healthy mice (n=60) using the Medical Internal Radiation Dose methodology and mouse model beta-absorbed fractions. To evaluate liver toxicity, alanine aminotranferase (AST) and aspartate aminotranferase ...

2009-08-15

470

Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model

The aim of this paper was to develop potential technetium 99m-labeled diagnostic imaging agents specific for the detection of A#beta# plaques. Based on previously obtained A#beta# plaque-specific biphenyls containing a benzimidazol group, "9"9Tc"m and Re-benzimidazol derivatives, ["9"9Tc"m(CO)_3]"+-EPBI and Re(CO)_3 Cl (EPBI), were prepared. The latter showed binding affinities towards A#beta#_(_1_#approx#_4_0_) aggregates in vitro (K_d=13.3 #mu#mol/L) by fluorophotometry. 2-(1-Ethylbenzimidazol-2-yl) pyridine (EPBI) and Re(CO)_3 Cl (EPBI) were synthesized. Binding affinity of Re(CO)_3 Cl (EPBI) for A#beta#_(_1_#approx#__4_0_) aggregates was determined. ["9"9Tc"m(CO)_3]"+-EPBI was prepared and analyzed by HPLC and paper eletrophoresis. Its biodistribution in mice was obtained. The K_d value of Re (CO)_3 Cl (EPBI) is 13.3 #mu#mol/L. Biodistribution of ["9"9Tc"m(CO)_3]"+-EPBI in mice shows brain penetration (0.63 #+-# 0.17) %ID/g (n=3) at 2 min ...

2009-11-01

471

The SPIRIT V Study:A Clinical Evaluation of the XIENCE V Everolimus-Eluting Coronary Stent System in the Treatment of Patients With De Novo Coronary Artery Lesions

Purpose: The purpose of this study was to evaluate the efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in an adjuvant setting with external beam radiation therapy (EBRT) in an experimental prostate cancer model in preparation for a Phase I clinical study in humans. Methods: For efficacy studies, i.m. DU145 and intraprostatic LNCaP C4-2 tumors were established in immune-deficient mice. Tumors were injected with the lytic, replication-competent Ad5-CD/TKrep adenovirus containing a cytosine deaminase (CD)/herpes simplex virus thymidine kinase (HSV-1 TK) fusion gene. Two days later, mice were administered 1 week of 5-fluorocytosine + ganciclovir (GCV) prodrug therapy and fractionated doses of EBRT (trimodal therapy). Tumor control rate of trimodal therapy was compared to that of EBRT alone. For toxicology studies, immune-competent male mice received a single intraprostatic ...

2002-11-01

472

British Library Electronic Table of Contents (United Kingdom)

ObjectivesThe SPIRIT V (A Clinical Evaluation of the XIENCE V Everolimus-Eluting Coronary Stent System in the Treatment of Patients With De Novo Coronary Artery Lesions) study is a post-market surveillance experience of the XIENCE V (Abbott Vascular, Santa Clara, California) everolimus-eluting stent (EES) in patients with higher-risk coronary anatomy. BackgroundPrevious pre-approval studies have shown the safety and efficacy of EES in highly selected groups of patients. MethodsThe SPIRIT V trial is a prospective, open label, single arm, multicenter study. Two thousand seven hundred patients with multiple de novo coronary artery lesions suitable for treatment with a planned maximum of 4 EES were enrolled at 93 centers in Europe, Asia Pacific, Canada, and South Africa. Lesions had a referenc...

2011-01-01

473

Summary report, California Department of Forestry and Fire Protection evaluation of full-face air-purifying respirators for wildland fire fighting use

Site Operator technical report. Final report (1992--1996)

Wildland fire suppression personnel employed by the CDF do not currently have the equipment to protect themselves from the short-term acute affects of smoke from wildland fires. In addition, no regulations exist that specify appropriate respiratory protection and the current air-purifying respirator technology and carbon monoxide monitoring has not been adapted to fit wildland fire suppression requirements. This three-year limited study evaluated the ability of wildland fire fighters to perform their normal job function while wearing full-face air-purifying respirators. In the first two years of this study we designed, developed and field tested a prototype ``smart`` air-purifying respirator which incorporated a real-time carbon monoxide monitor into a commercial full-face respirator.` Data on carbon monoxide exposure while fighting wildland fires was collected. During the third year of this study we evaluated eight different commercially available full-face air-purifying respirators ...

1996-02-01

474

Residential runoff as a source of pyrethroid pesticides to urban creeks.

The Southern California Edison Company (SCE) and the US Department of Energy (DOE) entered into cooperative agreement No. DE-FC07-91ID13077 on August 23, 1991, which expired on August 3, 1996. This cooperative agreement provided SCE with DOE cofunding for participation in the DOE`s Electric and Hybrid Vehicle Site Operator Program. In return, SCE provided the DOE with quarterly progress reports which include operating and maintenance data for the electric (EVs) vehicles in SCE`s fleet. Herein is SCE`s final report for the 1992 to 1996 agreement period. As of September 1, 1996 the SCE fleet had 65 electric vehicles in service. A total of 578,200 miles had been logged. During the agreement period, SCE sent the DOE a total of 19 technical reports (Appendix B). This report summarizes the technical achievements which took place during a long, productive and rewarding, relationship with the DOE.

1996-12-01

475

Residential runoff as a source of pyrethroid pesticides to urban creeks

Pyrethroid pesticides occur in urban creek sediments at concentrations acutely toxic to sensitive aquatic life. To better understand the source of these residues, runoff from residential neighborhoods around Sacramento, California was monitored over the course of a year. Pyrethroids were present in every sample. Bifenthrin, found at up to 73 ng/L in the water and 1211 ng/g on suspended sediment, was the pyrethroid of greatest toxicological concern, with cypermethrin and cyfluthrin of secondary concern. The bifenthrin could have originated either from use by consumers or professional pest controllers, though the seasonal pattern of discharge from the drain was more consistent with professional use as the dominant source. Stormwater runoff was more important than dry season irrigation runoff in transporting pyrethroids to urban creeks. A single intense storm was capable of discharging as much bifenthrin to an urban creek in 3h as that discharged over 6 months of ...

2008-08-03

476

Microprocessor-controlled anodic stripping voltammeter for trace metal analysis in tap water

Pyrethroid pesticides occur in urban creek sediments at concentrations acutely toxic to sensitive aquatic life. To better understand the source of these residues, runoff from residential neighborhoods around Sacramento, California was monitored over the course of a year. Pyrethroids were present in every sample. Bifenthrin, found at up to 73 ng/L in the water and 1211 ng/g on suspended sediment, was the pyrethroid of greatest toxicological concern, with cypermethrin and cyfluthrin of secondary concern. The bifenthrin could have originated either from use by consumers or professional pest controllers, though the seasonal pattern of discharge from the drain was more consistent with professional use as the dominant source. Stormwater runoff was more important than dry season irrigation runoff in transporting pyrethroids to urban creeks. A single intense storm was capable of discharging as much bifenthrin to an urban creek in 3 h as that discharged over 6 months of ...

2009-01-01

477

Measured impact of neighborhood tree cover on microclimate

The construction and use of a portable, microprocessor controlled anodic stripping voltameter for on-site simultaneous metal analysis of copper, lead and cadmium in tap water is discussed. The instrumental system is comprised of a programmable controller which permits keying in analytical parameters such as sparge time and plating time: a rotating cell for efficient oxygen removal and amalgam formation; and, data handling via a minicomputer or analog pen recorder. Plating and stripping potentials are controlled by a digital potentiostat; stripping is done using a staircase waveform with measurement of the current after a one msec delay. In this way charging current effects are minimized. Results of tap water analysis showed 3 +- 1 ..mu..g/L lead, 22 +- 0.3 ..mu..g/L copper, and less than 0.2 ..mu..g/L cadmium for a Berkeley, California tap water, and 1-1000 ..mu..g/L Cu, 1 -2 ..mu..g/L Pb for ten samples of Seattle, Washington tap water. Recommendations are given ...

1984-06-01

478

Lithospheric evolution in response to triple junction migration: A program to obtain seismic images of the MTJ region

In this paper we present results of our investigation into the relationship between urban microclimate and the local density of tree cover as measured in Sacramento, California. These results were obtained through analysis of data collected in a two-month long monitoring program with automatic weather stations installed at 15 residential locations throughout the city. Measured wind speeds showed a highly negative correlation with respect to tree cover. Daily peak air temperatures showed significant variation often differing from site to site by 2 to 4{degrees}C ({approx}3.5 to 7{degrees}F). A complex interaction between several competing factors is discussed leading to the conclusion that additional tree cover may actually increase urban air temperatures on synoptically cool days. It is suggested that this does not have a significant adverse affect in terms of overall summer urban cooling load. This is supported by an integrated analysis of the temperature data ...

1992-08-01

479

Integrated model of the shallow and deep hydrothermal systems in the East Mesa area, Imperial Valley, California

The authors will be conducting an integrated seismic experiment to image the structure of the crust and upper mantle of northern California immediately before and after passage of the Mendocino Triple Junction. The purpose of this representation is to describe the project to other scientists interested in geological and geophysical processes in this region and to solicit input relevant to detailed siting of the funded seismic profiles. The experiment encompasses two field seasons: onshore seismic refraction/wide angle reflection data acquisition along three long profiles scheduled for late summer, 1993; and MCS deep crustal seismic reflection data acquisition accompanied by simultaneous large aperture recording using both ocean bottom and onshore seismographs, tentatively scheduled for summer, 1994. This study represents a component of a long-term, multi-disciplinary effort on the part of many investigators to exploit this well defined system as an in-situ ...

1993-04-01

480

Identifying primary stressors impacting macroinvertebrates in the Salinas River (California, USA): Relative effects of pesticides and suspended particles

Geological, geophysical, thermal, petrophysical and hydrological data available for the East Mesa hydrothermal system that are pertinent to the construction of a computer model of the natural flow of heat and fluid mass within the system are assembled and correlated. A conceptual model of the full system is developed and a subregion selected for quantitative modeling. By invoking the Boussinesq approximation, valid for describing the natural flow of heat and mass in a liquid hydrothermal system, it is found practical to carry computer simulations far enough in time to ensure that steady-state conditions are obtained. Initial calculations for an axisymmetric model approximating the system demonstrate that the vertical formation permeability of the deep East Mesa system must be very low (k/sub v/ approx. 0.25 to 0.5 md). Since subsurface temperature and surface heat flow data exhibit major deviations from the axisymmetric approximation, exploratory three-dimensional calculations are ...

1982-01-01

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481

High voltage high brightness electron accelerator with MITL voltage adder coupled to foilless diode

Laboratory dose-response experiments with organophosphate and pyrethroid pesticides, and dose-response experiments with increasing particle loads were used to determine which of these stressors were likely responsible for the toxicity and macroinvertebrate impacts previously observed in the Salinas River. Experiments were conducted with the amphipod Hyalella azteca, the baetid mayfly Procloeon sp., and the midge Chironomus dilutus (Shobanov, formerly Chironomus tentans). The results indicate the primary stressor impacting H. azteca was pesticides, including chlorpyrifos and permethrin. The mayfly Procloeon sp. was sensitive to chlorpyrifos and permethrin within the range of concentrations of these pesticides measured in the river. Chironomus dilutus were sensitive to chlorpyrifos within the ranges of concentrations measured in the river. None of the species tested were affected by turbidity as high as 1000 NTUs. The current study shows that pesticides are more important acute stressors ...

2006-06-01

482

GeoSAR program: IFSAR validation and terrain classification from polarimetry

The design and analysis of a high brightness electron beam experiment under construction at Sandia National Laboratory is presented. The beam energy is 12 MeV, the current 35 endash 40 kA, the rms radius 0.5 mm, and the pulse duration FWHM 40 ns. The accelerator is SABRE [J. Corley, J. A. Alexander, P. J. Pankuch, C. E. Heath, D. L. Johnson, J. J. Ramirez, and G. J. Denison, in Proceedings of the Eighth International IEEE Pulsed Power Conference, San Diego, California, 1991 (IEEE, New York, 1991), p. 920], a pulsed inductive voltage adder, and the electron source is a magnetically immersed foilless diode. This experiment has as its goal to stretch the technology to the edge and produce the highest possible electron current in a submillimiter radius beam. copyright 1996 American Institute of Physics.

1995-10-13

483

Genetic control of cotton insects: The pink bollworm as a working programme

The GeoSAR (geographic synthetic aperture radar) program is a Defense Advanced Research Projects Agency (DARPA) sponsored program organized in cooperation with the Jet Propulsion Laboratory (JPL) and the California Department of Conservation. Some aspects of the program have been existent for almost two years. The technical goal of the program has been the development of rapid-mapping radar technologies, and has now, as its principal challenge, the development of a capability for terrain mapping under foliage. In this paper, we discuss validation of current technology and examine the utility of data products currently produced by the Environmental Research Institute of MIchigan's (ERIM) IFSARE, JPL's TOPSAR, and JPL's AIRSAR. We find that ERIM's X-band IFSARE system produces elevation maps to better than 2-m accuracy. Based on this we determine that TOPSAR elevation maps are accurate to at least 5 m. We also demonstrate the utility of JPL's AIRSAR's L-band radar ...

1996-06-01

484

Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii, and California: demographic, physical, dietary, and biochemical characteristics

Establishment of a continuous population has been prevented over a 24 year period in the San Joaquin Valley, USA, through continuous, daily in-season release of sterile pink bollworms based on an extensive trap monitoring programme. A post-harvest crop destruction ordinance and occasional use of pheromones as disruptants were the only other factors used by programme management, except in 1990. In 1990, the programme used a conventional insecticide on 280 acres (113 ha) out of 1.18 million acres (477,546 ha) of cotton. During the four year period 1986-1989, a management system was explored using a high rate pheromone disruption system and sterile insects. Major reductions in conventional insecticide usage, while maintaining extremely low populations, were evident in this semi-isolated valley of southern California. It is hoped that this will provide a model for a future large scale test on up to 20,000 acres (8100 ha) of cotton. (author). 11 refs, 1 fig., 7 tabs.

1993-09-01

485

Energy Engineering Analysis Program Limited Energy Study, Fort Hunter-Liggett, California. Volume 1

These summary descriptive data of ethnically similar cohorts of indigenous and migrant Japanese males have shown similarities or slight differences in characteristics wholly or largely genetically determined, such as blood groups, stature, and skeletal size. Differences have been noted in characteristics largely environmental or behavioral, such as diet and cigarette smoking habit, as well as in characteristics determined by a varying mixture of genetic and environmental influences, such as weight, blood pressure, glucose tolerance, and serum lipid and uric acid levels. Detailed analyses of the distributions of laboratory variables, of dietary data obtained by different methods, and of correlations among laboratory, dietary, physical, and demographic variables are currently in progress. Also part of the study plan are determinations of disease prevalence from evaluation of examination, laboratory, and electrocardiographic findings, of disease incidence from repeat examinations and from ...

486

Development status of a small, direct-injection diesel engine at Isuzu

The purpose of this study is to develop projects and actions that will reduce facilities energy consumption and operating costs at Fort Hunter Liggett. Implementation of these projects will contribute to achieving the goal of the Army Facilities Energy Plan of a reduction in energy consumption per square foot of building floor area of 20 percent by FY2OOO from FY1985 baseline levels, There are 205 numbered structures at Fort Hunter Liggett, containing a total of 791,034 square feet of gross floor space. This United Energy Study evaluates 52 surveyed buildings with results extended to an additional 44 identical or similar buildings. Together, these buildings contain a total of 632,386 gross square feet and account for approximately 93 percent of overall energy usage. Present Energy Consumption Total energy consumption at Fort Hunter Ligett in FY 1992 of non-transportation energy sources was 79,728 million Btu. This figure includes electricity at 3,413 Btu per kwh, No. 2 fuel oil at ...

1993-12-31

487

Current and Future Costs for Parabolic Trough and Power Tower Systems in the US Market: Preprint

Development status of small direct injection diesel engine at Isuzu Motors Ltd. is reviewed. There is much difficulty in combustion optimization of small DI engines, due to small combustion chamber volume, large surface to volume ratio, wide engine speed range and so on. Novel ideas in the area of injection system, combustion chamber and induction swirl were tried to solve these problems and their effects are presented here. Our prototype DI engines which adopted some of these ideas has turned out to have better fuel economy by about 15 percent, 2 - 3 dB(A) higher noise level than IDI and almost the same power output performance as IDI. As to exhaust emissions, they have a possibility to conform to '86 California emission standards, in inertia weight classes up to 2625 LBS. The remaining problem areas are noise emission, durability of injection pump and cabin heater performance. These problems must be solved by further innovation, before DI engines will be ...

1985-01-01

488

Correct implementation of the Argonne QuickSite{sup SM} process for preremedial site investigations

NREL's Solar Advisor Model (SAM) is employed to estimate the current and future costs for parabolic trough and molten salt power towers in the US market. Future troughs are assumed to achieve higher field temperatures via the successful deployment of low melting-point, molten-salt heat transfer fluids by 2015-2020. Similarly, it is assumed that molten salt power towers are successfully deployed at 100MW scale over the same time period, increasing to 200MW by 2025. The levelized cost of electricity for both technologies is predicted to drop below 11 cents/kWh (assuming a 10% investment tax credit and other financial inputs outlined in the paper), making the technologies competitive in the marketplace as benchmarked by the California MPR. Both technologies can be deployed with large amounts of thermal energy storage, yielding capacity factors as high as 65% while maintaining an optimum LCOE.

2010-10-01

489

Constant-pressure charging of a liquid-dominated geothermal reservoir

Expedited site characterization (ESC), developed by Argonne National Laboratory, is an interactive, integrated process emphasizing the use of existing data of sufficient quality, multiple complementary characterization methods, and on-site decision making to optimize environmental site investigations. The Argonne ESC is the basis for the provisional ESC standard guide of the ASTM (American Society for Testing and Materials). QuickSite{sup SM} is the implementation package developed by Argonne to facilitate ESC of sites contaminated with hazardous wastes. At various sites, Argonne has successfully implemented QuickSite{sup SM} and demonstrated the technical superiority of the ESC process over traditional methodologies guided by statistics and random-sampling approaches. A key feature in the success of QuickSite{sup SM} investigations is achieving an understanding of the subsurface geologic and hydrogeologic controls and processes at a site before extensive sampling efforts begin. The ...

1997-10-01

490

Chalk point cooling tower project: effects of simulated saline cooling tower drift on woody species. Master's thesis

A two-dimensional mathematical model of a fault controlled geothermal reservoir has been developed. Heated water rising in a fault is assumed to charge a reservoir which is overlain by a thin impermeable, thermally conducting cap rock. The mass flow rate or the pressure associated with the charging process at the fault inlet is unknown and can only be estimated. Thus, the pressure in the fault at the bottom of the reservoir is assumed to be prescribed. Quasi-analytic solutions for the distributions of velocity, pressure, and temperature are obtained in the fault-reservoir system for high Rayleigh number flow. In this approximation, the upwelling fluid does not cool off appreciably until it reaches the cold upper boundary of the reservoir and encounters conductive heat loss. The thermal boundary layer, which is thin at the top of the fault, grows outward laterally and occupies the full thickness of the aquifer in the far-field. This study shows that a near isothermal temperature ...

1982-03-01

491

COVFILS-2: neutron data and covariances for sensitivity and uncertainty analysis

Cooling towers of power plants are used to dissipate waste heat into the atmosphere. If saline water is used for cooling, a saline aerosol known as drift is released into the atmosphere. Drift effects on vegetation are not well known. To simulate drift for a field study, cooling tower basin water was sprayed thirty separate times during a 46-day period in 1975 on Virginia pine (Pinus virginiana), flowering dogwood (Cornus florida), tulip tree (Liriodendron tulipfera), and California privet (Ligustrum ovalifolium), Norway spruce (Picea abies), and white ash (Fraxinus americana) were added in 1976 and all trees were sprayed 43 times during a 59-day period. Only dogwood leaves showed significant injury. Absence of injury on other species was probably due to the ability of their leaves to exclude, or reduce absorption of, toxic concentrations of the ions supplied.

1977-07-01

492

COVFILS-2: neutron data and covariances for sensitivity and uncertainty analysis

The author have prepared a new, fusion-oriented library of multigroup neutron cross sections, scattering matrices, and covariances (uncertainties and correlations). The 74-group library, called COVFILS-2, has been used, or will be used, by neutronics groups at Los Alamos National Lab. (LANL) at the University of California at Los Angeles, and at the Swiss Federal Institute for Reactor Research in the sensitivity and uncertainty analysis of fusion-relevant integral experiments such as the Li/sub 2/O experiment performed at the Fast Neutron Source Facility in Japan and the Lithium breeding module experiment planned at the LOTUS facility in Lausanne, Switzerland. Another intended use of this library is in the estimation of the uncertainty in key performance parameters (such as the breeding ratio) of conceptual fusion reactors. The 14 materials included in the first version of COVFILS-2 are hydrogen, /sup 6/Li, /sup 7/Li, beryllium, carbon, nitrogen, oxygen, sodium, ...

1986-01-01

493

Aspects of Stability Related to the Colliding Beam Fusion = Reactor

The author have prepared a new, fusion-oriented library of multigroup neutron cross sections, scattering matrices, and covariances (uncertainties and correlations). The 74-group library, called COVFILS-2, has been used, or will be used, by neutronics groups at Los Alamos National Lab. (LANL) at the University of California at Los Angeles, and at the Swiss Federal Institute for Reactor Research in the sensitivity and uncertainty analysis of fusion-relevant integral experiments such as the Li_2O experiment performed at the Fast Neutron Source Facility in Japan and the Lithium breeding module experiment planned at the LOTUS facility in Lausanne, Switzerland. Another intended use of this library is in the estimation of the uncertainty in key performance parameters (such as the breeding ratio) of conceptual fusion reactors. The 14 materials included in the first version of COVFILS-2 are hydrogen, "6Li, "7Li, beryllium, carbon, nitrogen, oxygen, sodium, aluminum, ...

1986-06-15

494

Are there SO_2 externality costs beyond the Clean Air Act Amendments of 1990?

Recent experiments with TFTR, D-III-D and JET involving the injection and trapping of low density beams of high energy large orbit ions indicate that large orbit non-adiabatic ions slow down and diffuse classically in the presence of anomalous fluctuations and transport of adiabatic majority particles. Accordingly, we consider conceptual fusion reactors(N. Rostoker, M.W. Binderbauer and H.J. Monkhorst, Science) 278, 1419 (1997). based on classical confinement of fuel ions and fusion products(M.W. Binderbauer and N. Rostoker, J. Plasma Phys.) 56, 451 (1996).. The magnetic confinement geometry of the proposed designs is a Field Reversed Configuration. A survey of experimental results on instabilities and their characteristics as related to these reactor concepts is presented. Particular focus will be given to long wavelength (as compared to gyro-radius) and low frequency (?<< c/r_o, r_o=3D major radius of annular current ring) instabilities as they are most harmful to such systems. ...

1998-11-01

495

Analyses of mixed-hydrocarbon binary thermodynamic cycles for moderate-temperature geothermal resources

Inclusion of environmental externality costs in the selection of utility resources has become a reality in New York, Massachusetts, Nevada and California. Soon several other jurisdictions are likely to join these states in using environmental externality costs in decision-making. The consideration of environmental externalities are bound to profoundly affect utility decision-making in the future. So far attention has focused largely on air emission externalities of SO_2, NO_x and CO_2. However, the recent Clean Air Act Amendments (CAAA) will reduce SO_2 emissions from utilities by about 50 percent. With such a large reduction in SO_2 loading, the question has been raised as to the need to further consider SO_2 externality costs in decision-making. This paper comments on this issue. By using generation and emission data from New York utilities, the paper shows that SO_2 emission externalities exist even after complying with requirements of the CAAA.

1992-06-21

496

A cultural research approach to instrument development: the case of breast and cervical cancer screening among Latino and Anglo women.

A number of binary geothermal cycles utilizing mixed hydrocarbon working fluids were analyzed with the overall objective of finding a working fluid which can produce low-cost electrical energy using a moderately-low temperature geothermal resource. Both boiling and supercritical shell-and-tube cycles were considered. The performance of a dual-boiling isobutane cycle supplied by a 280/sup 0/F hydrothermal resource (corresponding to the 5 MW pilot plant at the Raft River site in Idaho) was selected as a reference. To investigate the effect of resource temperature on the choice of working fluid, several analyses were conducted for a 360/sup 0/F hydrothermal resource, which is representative of the Heber resource in California. The hydrocarbon working fluids analyzed included methane, ethane, propane, isobutane, isopentane, hexane, heptane, and mixtures of those pure hydrocarbons. For comparison, two fluorocarbon refrigerants were also analyzed. These fluorocarbons, ...

1981-02-01

497

A Wide-Band Electromagnetic Impedance Profiling System forNon-Invasive Subsurface Characterization

To illustrate the implementation of a bottom-up approach to the study of culture in health disparities, this article describes the development of a cultural cancer screening scale (CCSS) using mixed methodologies. The aim was to identify cultural factors relevant to breast and cervical cancer screening, develop an instrument to assess them and examine its preliminary psychometric properties among Latin American (Latino) and non-Latino White (Anglo) women in Southern California. Seventy-eight Latino and Anglo women participated in semi-structured interviews, which were content coded based on Triandis' methods for the analysis of subjective culture. Based on the emerging cultural elements, items relevant to cancer screening were developed and pilot tested with 161 participants. After the instrument was refined, 314 Latino and Anglo women from various socioeconomic backgrounds completed the CCSS and data were factor analyzed resulting in five cultural factors: cancer ...

2010-09-23

498